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Sample records for design tailor-made evaluation

  1. A systematic methodology for design of tailor-made blended products

    DEFF Research Database (Denmark)

    Yunus, Nor Alafiza Binti; Gernaey, Krist; Woodley, John

    2014-01-01

    A systematic methodology for design of tailor-made blended products has been developed. In tailor-made blended products, one identifies the product needs and matches them by blending different chemicals. The systematic methodology has four main tasks. First, the design problem is defined: the pro......, the methodology is highlighted through two case studies involving gasoline blends and lubricant base oils....

  2. Design of tailor-made chemical blend using a decomposition-based computer-aided approach

    DEFF Research Database (Denmark)

    Yunus, Nor Alafiza; Gernaey, Krist; Manan, Z.A.

    2011-01-01

    Computer aided techniques form an efficient approach to solve chemical product design problems such as the design of blended liquid products (chemical blending). In chemical blending, one tries to find the best candidate, which satisfies the product targets defined in terms of desired product...... methodology for blended liquid products that identifies a set of feasible chemical blends. The blend design problem is formulated as a Mixed Integer Nonlinear Programming (MINLP) model where the objective is to find the optimal blended gasoline or diesel product subject to types of chemicals...... and their compositions and a set of desired target properties of the blended product as design constraints. This blend design problem is solved using a decomposition approach, which eliminates infeasible and/or redundant candidates gradually through a hierarchy of (property) model based constraints. This decomposition...

  3. Computer-aided approach for design of tailor-made blended products

    DEFF Research Database (Denmark)

    Yunus, Nor Alafiza; Gernaey, Krist; Woodley, John

    2012-01-01

    A computer-aided methodology has been developed for the design of blended (mixture) products. Through this methodology, it is possible to identify the most suitable chemicals for blending, and “tailor” the blend according to specified product needs (usually product attributes, e.g. performance...... as well as regulatory). The product design methodology has four tasks. First, the design problem is defined: the product needs are identified, translated into target properties and the constraints for each target property are defined. Secondly, target property models are retrieved from a property model...

  4. Property Model-based Tailor-made Design of Chemical-based Products

    DEFF Research Database (Denmark)

    Kalakul, Sawitree

    Computer-aided model-based methods and tools are increasingly playing important roles in chemical product design. They have the potential to very quickly search for and identify reliable product candidates that can then be verified through experiments. Inthis way, the time and resources spent...... on experiment are reduced leading to faster and cheaper to market the products. The tools also help to manage the solution of product design problems, which usually require efficient handling of model-data-knowledge from different sources and at different time and size scales. The main contribution...... the needed template for a desired product is not available. VPPD-Lab employs a suite of algorithms(such as database search, molecular and mixture blend design) and toolboxes (such asproperty calculations and property model consistency tests) for specific product property prediction, design, and/or analysis...

  5. Systematic Methodology for Design of Tailor-Made Blended Products: Fuels and Other Blended Products

    DEFF Research Database (Denmark)

    Yunus, Nor Alafiza Binti

    property values are verified by means of rigorous models for the properties and the mixtures. Besides the methodology, as the main contribution, specific supporting tools that were developed to perform each task are also important contributions of this research work. The applicability of the developed...... important in daily life, since they not only keep people moving around, but also guarantee that machines and equipment work smoothly. The objective of this work is to tackle the blending problems using computer-aided tools for the initial stage of the product design. A systematic methodology for design...... methodology and tools was tested through two case studies. In the first case study, two different gasoline blend problems have been solved. In the second case study, four different lubricant design problems have been solved....

  6. An Integrated Methodology for Design of Tailor-Made Blended Products

    DEFF Research Database (Denmark)

    Yunus, Nor Alafiza; Gernaey, Krist; Woodley, John

    2012-01-01

    is analyzed. Finally, experimental work (or detailed model-based verification) is conducted in stage three to validate the selected blend candidates. In this study, the product design stage is highlighted through a case study of gasoline blends with bio-based chemicals. The objective of this study...... is to identify blended gasoline products that match (or improve) the performance of the conventional gasoline....

  7. Tailor-made Design of Chemical Blends using Decomposition-based Computer-aided Approach

    DEFF Research Database (Denmark)

    Yunus, Nor Alafiza; Manan, Zainuddin Abd.; Gernaey, Krist

    (properties). In this way, first the systematic computer-aided technique establishes the search space, and then narrows it down in subsequent steps until a small number of feasible and promising candidates remain and then experimental work may be conducted to verify if any or all the candidates satisfy......Computer aided technique is an efficient approach to solve chemical product design problems such as design of blended liquid products (chemical blending). In chemical blending, one tries to find the best candidate, which satisfies the product targets defined in terms of desired product attributes...... is decomposed into two stages. The first stage investigates the mixture stability where all unstable mixtures are eliminated and the stable blend candidates are retained for further testing. In the second stage, the blend candidates have to satisfy a set of target properties that are ranked according...

  8. Generic Model-Based Tailor-Made Design and Analysis of Biphasic Reaction Systems

    DEFF Research Database (Denmark)

    Anantpinijwatna, Amata

    systems have a broad range of application, such as the manufacture of petroleum based chemicals, pharmaceuticals, and agro-bio products. Major considerations in the design and analysis of biphasic reaction systems are physical and chemical equilibria, kinetic mechanisms, and reaction rates. The primary...... contribution of this thesis is the development of a systematic modelling framework for the biphasic reaction system. The developed framework consists of three modules describing phase equilibria, reactions and mass transfer, and material balances of such processes. Correlative and predictive thermodynamic......Biphasic reaction systems are composed of immiscible aqueous and organic liquid phases where reactants, products, and catalysts are partitioned. These biphasic conditions point to novel synthesis paths, higher yields, and faster reactions, as well as facilitate product separation. The biphasic...

  9. Field evaluation of a tailor-made new passive sampler for the determination of NO2 levels in ambient air.

    Science.gov (United States)

    Ozden, Ozlem; Dogeroglu, Tuncay

    2008-07-01

    This study describes the field evaluation of a tailor-made new glass passive sampler developed for the determination of NO(2), based on the collection on triethanolemine (TEA)-coated fibre filter paper. The sampler has been derived from a Palmes design. The overall uncertainty of the sampler was determined by using Griess-Saltzman ASTM D 1607 standard test method as a reference method. The agreement between the results of the passive sampler and the reference method was +/-7.90% with the correlation coefficient of 0.90. Method precision in terms of coefficient of variance (CV) for three simultaneously applied passive samplers was 8.80%. The uptake rate of NO(2) was found to be 2.49 ml/min in a very good agreement with the value calculated from theory (2.63 ml/min). Sampler detection limit was 1.99 microg/m(3) for an exposure period of 1 week and the sampler can be stored safely for a period of up to 6 weeks before exposure. A comparison of the sampler performance was conducted against a commercially available diffusion tube (Gradko diffusion tube). The results from the applied statistical paired t test indicated that there was no significant difference between the performances of two passive samplers (R (2) > 0.90). Also, another statistical comparison was carried out between the dark and transparent glass passive samplers. The results from the dark-colour sampler were higher than that from the transparent sampler (approximately 25%) during the summer season because of the possible photodegradation of NO(2)-TEA complex.

  10. Changing Social Structure in Europe calls for Tailor-made, Barrier-free Living and new Interior Design

    Directory of Open Access Journals (Sweden)

    Brausch Carsten

    2015-06-01

    Full Text Available Europe is experiencing a demographic change, resulting in a change in social structure. People are living longer and birth rates are declining. This changing structure in Europe poses special challenges for housing designers and builders. A new approach in the design of real estate must be created and implemented that caters for the future needs of the occupants of the living space in all phases and allows residents to remain self-sufficient in their "home" for as long as possible. In the earliest stages of design, the typical requirements for each phase of life of future, potential residents must already be considered. This is especially true for people with special protection needs, such as those with visual or hearing impairments.

  11. Tailor-made surface plasmon polaritons above the bulk plasma frequency: a design strategy for indium tin oxide

    International Nuclear Information System (INIS)

    Brand, S; Abram, R A; Kaliteevski, M A

    2010-01-01

    A simple phase-matching approach is employed as a design aid to engineer surface plasmon polariton states at the interface of an indium tin oxide layer on the top of a Bragg reflector. By altering the details of the reflector, and in particular the ordering of the layers and the thickness of the layer adjacent to the indium tin oxide, it is possible to readily adjust the energy of these states. Examples of structures engineered to give rise to distinctive features in the reflectivity spectra above the bulk screened plasma frequency for states of both possible polarizations are presented.

  12. Microstructural gradients in thin hard coatings -- tailor-made

    DEFF Research Database (Denmark)

    Pantleon, Karen; Oettel, Heinrich

    1998-01-01

    ) alternating sputtering with and without substrate voltage and (c) pulsed bias voltage. On the basis of X-ray diffraction measurements, it is demonstrated that residual stress gradients and texture gradients can be designed tailor-made. Furthermore, results of microhardness measurements and scratch tests...

  13. Uncovering the Design Principle of Amino Acid-Derived Photoluminescent Biodots with Tailor-Made Structure-Properties and Applications for Cellular Bioimaging.

    Science.gov (United States)

    Xu, Hesheng Victor; Zheng, Xin Ting; Zhao, Yanli; Tan, Yen Nee

    2018-06-01

    Natural amino acids possess side chains with different functional groups (R groups), which make them excellent precursors for programmable synthesis of biomolecule-derived nanodots (biodots) with desired properties. Herein, we report the first systematic study to uncover the material design rules of biodot synthesis from 20 natural α-amino acids via a green hydrothermal approach. The as-synthesized amino acid biodots (AA dots) are comprehensively characterized to establish a structure-property relationship between the amino acid precursors and the corresponding photoluminescent properties of AA dots. It was found that the amino acids with reactive R groups, including amine, hydroxyl, and carboxyl functional groups form unique C-O-C/C-OH and N-H bonds in the AA dots which stabilize the surface defects, giving rise to brightly luminescent AA dots. Furthermore, the AA dots were found to be amorphous and the length of the R group was observed to affect the final morphology (e.g., disclike nanostructure, nanowire, or nanomesh) of the AA dots, which in turn influence their photoluminescent properties. It is noteworthy to highlight that the hydroxyl-containing amino acids, that is, Ser and Thr, form the brightest AA dots with a quantum yield of 30.44% and 23.07%, respectively, and possess high photostability with negligible photobleaching upon continuous UV exposure for 3 h. Intriguingly, by selective mixing of Ser or Thr with another amino acid precursor, the resulting mixed AA dots could inherit unique properties such as improved photostability and significant red shift in their emission wavelength, producing enhanced green and red fluorescent intensity. Moreover, our cellular studies demonstrate that the as-synthesized AA dots display outstanding biocompatibility and excellent intracellular uptake, which are highly desirable for imaging applications. We envision that the material design rules discovered in this study will be broadly applicable for the rational

  14. Oromucosal multilayer films for tailor-made, controlled drug delivery.

    Science.gov (United States)

    Lindert, Sandra; Breitkreutz, Jörg

    2017-11-01

    The oral mucosa has recently become increasingly important as an alternative administration route for tailor-made, controlled drug delivery. Oromucosal multilayer films, assigned to the monograph oromucosal preparations in the Ph.Eur. may be a promising dosage form to overcome the requirements related to this drug delivery site. Areas covered: We provide an overview of multilayer films as drug delivery tools, and discuss manufacturing processes and characterization methods. We focus on the suitability of characterization methods for particular requirements of multilayer films. A classification was performed covering indication areas and APIs incorporated in multilayer film systems for oromucosal use in order to provide a summary of data published in this field. Expert opinion: The shift in drug development to high molecular weight drugs will influence the field of pharmaceutical development and delivery technologies. For a high number of indication areas, such as hormonal disorders, cardiovascular diseases or local treatment of infections, the flexible layer design of oromucosal multilayer films provides a promising option for tailor-made, controlled delivery of APIs to or through defined surfaces in the oral cavity. However, there is a lack of discriminating or standardized testing methods to assess the quality of multilayer films in a reliable way.

  15. Tailor-made blanks for the aircraft industry

    NARCIS (Netherlands)

    Zad Poor, A.A.

    2010-01-01

    Tailor-Made Blanks (TMBs) are hybrid assemblies made of sheet metals with different materials and/or thicknesses that are joined together prior to forming. Alternatively, a monolithic sheet can be machined to create required thickness variations (machined TMBs). The possibility of having several

  16. Faster, deeper and safer drilling with tailor-made ``designer tools`` - a new approach in borehole technology; Schneller, weiter und sicherer Bohren mit massgeschneiderten ``Designer Garnituren`` - Ein neuer Ansatz in der Bohrtechnologie

    Energy Technology Data Exchange (ETDEWEB)

    Reich, M. [Technical Services Baker Hughes INTEQ, Celle (Germany)

    1998-12-31

    In the past few years, progress has been made in all deep drilling components, but a systemic approach tends to be neglected. Combinations of optimized components alone will not ensure maximum heading rates, long life and economic efficiency. Since about two years ago, research is being made into ``designer tool combinations``. The contribution describes a typical example along with the software used to select the components. (orig.) [Deutsch] In den vergangenen Jahren sind deutliche Fortschritte bei der Entwicklung aller fuer Tiefbohrungen erforderlicher Komponenten erzielt worden. Vermisst wird aber ein Ansatz zum Systemdenken, da leider haeufig das Zusammenspiel dieser Komponenten im praktischen Einsatz nicht beruecksichtigt wird. Die Kombination optimierter Einzelkomponenten allein fuehrt weder zu maximalem Bohrfortschritt noch zu hoechster Lebensdauer oder einem wirtschaftlichen Optimum. Beste Ergebnisse sind vielmehr von Bohrgarnituren zu erwarten, die nach mechanischen und hydraulischen Gesetzmaessigkeiten fuer eine maximale Leistung des Gesamtsystems zusammengestellt werden. Diese relativ einfache Erkenntnis wird erst seit kurzem systematisch in die Praxis umgesetzt. In den letzten zwei Jahren wurden mehrere umfassende Programme zur Optimierung von Bohrgarnituren durchgefuehrt. Die Ergebnisse, die mit diesen `Designer-Bohrgarnituren` erzielt wurden, demonstrieren in eindrucksvoller Weise das Verbesserungspotential. Nachfolgend werden die typischen Komponenten einer `Designer-Garnitur` beschrieben und ein Einblick in die Software gegeben, die zur Optimierung eingesetzt wird. Die erreichten Verbesserungen gegenueber den zuvor benutzten konventionellen Garnituren werden mit Fallbeispielen belegt. (orig.)

  17. [Preliminary analysis of the effects of tailor-made notched music therapy on chronic idiopathic tinnitus].

    Science.gov (United States)

    Tian, R R; Diao, M F; Tian, F J; Sun, J J; Lin, X

    2017-05-07

    Objective: Tailor-made notched music was applied to alleviate the symptoms of chronic idiopathic tinnitus and compared its effectiveness with other existing sound treatment of tinnitus. Methods: Subjects ( n =43; ears=75 )were recruited during June 2015 to October 2016 from the out-patients of our hospital. These patients had chronic (longer than 6months) and idiopathic tinnitus, with or without significant sensorineural hearing loss. In the prospective design, the patients were randomly divided into group A (treated with tailor-made notched music) and group B (treated with analogous sound masking), and received the treatment for 3 months. The tinnitus scale, tinnitus questionnaire and audiological findings were evaluated before treatment, and at one month and three months after treatment started. Results: After onemonth of treatment, the effective rate between the two groups was 40.9% and 42.9%, there was no significant difference between the two groups (χ(2)= 0.017, P =0.897). The average VAS for patients in group A showed more decrease in group A than in group B(VAS: 1.8 vs . 0.8, the percentage : 29.5% vs . 13.6%), but there was no significant difference between the two groups ( t =-1.450, P =0.155). After 3 months of treatment, the effective rates were 68.2% and 23.8%, respectively. There was significant difference between the two groups (χ(2)= 8.503, P =0.004). The difference of the VAS scores between the two groups was statistically significant ( t =-3.263, P =0.002), and the VAS score of group A was less.After 3 months of treatment, there was significant decreaseinthe average tinnitus loudness for patients in group A( t =5.569, P tinnitus handicap inventory (THI) ( F =7.334, P tinnitus(χ(2)=11.289, P 0.05). Conclusions: Our resultssuggest that long-term normalized listening to tailor-made notched music, can significantly reduce the perceived tinnitus loudness in varying degrees and improve the quality of life of patients. The effects and possible

  18. Textual healing: tailor-made kabbalistic therapeutics in Jerusalem.

    Science.gov (United States)

    Guzmen-Carmeli, Shlomo; Sharabi, Asaf

    2017-10-30

    This paper, based on fieldwork conducted in a Jerusalem yeshiva, describes how the yeshiva, a traditional institute of religious studies, also serves as an institution of healing and personal therapy in which sacred religious texts assume a central place. The article focuses on personal sessions between the rabbi who heads the yeshiva, and his audience of believers who turn to him for help in coping with personal hardships and tribulations. The paper contextualizes and elaborates upon the concept of 'deep healing' to describe how the rabbi uses his regular 'tool kit' to diagnose the problems of the person facing him and to offer optimal, personalized therapy. The rabbi uses religious texts to create textual deep healing processes that are tailor-made for the individual supplicant and are intended to accompany supplicants for a long period of time.

  19. Thoracoscopic surgery for pulmonary metastases after chemotherapy using a tailor-made virtual lung

    International Nuclear Information System (INIS)

    Akiba, Tadashi; Marushima, Hideki; Kinoshita, Satoki; Kamiya, Noriteru; Odaka, Makoto; Takeyama, Hiroshi; Morikawa, Toshiaki

    2011-01-01

    Details with regard to the standard criteria for a therapeutic metastasectomy and the use of video-assisted thoracic surgery (VATS) remain elusive. To evaluate the feasibility of VATS using a tailor-made virtual lung for patients with pulmonary metastases after chemotherapy, we reviewed the following cases. Clinical data from October 2006 to April 2010 were obtained from patients who received chemotherapy before a pulmonary metastasectomy (lobectomy or segmentectomy). VATS was the primarily selected surgical approach except for treating hilar lesions. A lobectomy was performed when the metastasis was greater than 3.0 cm in diameter or located deeply in the lobe. Tailor-made virtual lungs were created using three-dimensional multidetector computed tomography before lobectomy on a routine basis. The virtual lung consisted of three-dimensional pulmonary vessels, a tracheobronchial tree, pulmonary parenchyma, and tumors. Twelve operations, consisting of 1 segmentectomy, 10 lobectomies, and 1 wedge bronchoplasty upper lobectomy, were performed on 11 patients during the study period. VATS was completed in 10 of these 12 operations. The mean operative time for the lobectomies was 257 min, and the mean operative bleeding volume was 215 ml. Two cases experienced postoperative transient atrial fibrillation, and no mortalities associated with these operations were reported. VATS was performed safely in instances of metastasectomy after chemotherapy, and the tailor-made virtual lung assisted in lung orientation during the operation. (author)

  20. Development of tailor-made silica fibres for TL dosimetry

    International Nuclear Information System (INIS)

    Bradley, D.A.; Abdul Sani, Siti F.; Alalawi, Amani I.; Jafari, S.M.; Noor, Noramaliza M.; Hairul Azhar, A.R.; Mahdiraji, Ghafour Amouzad; Tamchek, Nizam; Ghosh, S.; Paul, M.C.; Alzimami, Khalid S.; Nisbet, A.; Maah, M.J.

    2014-01-01

    The Ge dopant in commercially available silica optical fibres gives rise to appreciable thermoluminscence (TL), weight-for-weight offering sensitivity to MV X-rays several times that of the LiF dosimeter TLD100. The response of these fibres to UV radiation, X-rays, electrons, protons, neutrons and alpha particles, with doses from a fraction of 1 Gy up to 10 kGy, have stimulated further investigation of the magnitude of the TL signal for intrinsic and doped SiO 2 fibres. We represent a consortium effort between Malaysian partners and the University of Surrey, aimed at production of silica fibres with specific TL dosimetry applications, utilizing modified chemical vapour deposition (MCVD) doped silica–glass production and fibre-pulling facilities. The work is informed by defect and dopant concentration and various production dependences including pulling parameters such as temperature, speed and tension; the fibres also provide for spatial resolutions down to <10 µm, confronting many limitations faced in use of conventional (TL) dosimetry. Early results are shown for high spatial resolution (∼0.1 mm) single-core Ge-doped TL sensors, suited to radiotherapy applications. Preliminary results are also shown for undoped flat optical fibres of mm dimensions and Ge-B doped flat optical fibres of sub-mm dimensions, with potential for measurement of doses in medical diagnostic applications. - Highlights: • Optical fibres tailor-made for TL dosimetry. • Sensitive to diagnostic as well as therapy doses in medicine. • Preform and fibre pulling facilities. • Relative TL and EPR measurements

  1. Small hydroelectric power plants - shelf goods or tailor-made?

    International Nuclear Information System (INIS)

    Aas, Trond R.

    2002-01-01

    If small hydroelectric power plants are defined to be hydroelectric power plants of up to a few 1000 kW, they should be shelf goods because of cost considerations. Design of small hydroelectric power plants is a many-sided optimization task, on a level with constructing larger hydro power plants. But the budget for a small hydro power plant does not permit any comprehensive evaluations. The most important costs are the one-time costs in the form of investments and the following annual costs in the form of operation and maintenance, and losses. Financing costs are not considered in this article

  2. Microbial production of polyhydroxybutyrate with tailor-made properties: an integrated modelling approach and experimental validation.

    Science.gov (United States)

    Penloglou, Giannis; Chatzidoukas, Christos; Kiparissides, Costas

    2012-01-01

    The microbial production of polyhydroxybutyrate (PHB) is a complex process in which the final quantity and quality of the PHB depend on a large number of process operating variables. Consequently, the design and optimal dynamic operation of a microbial process for the efficient production of PHB with tailor-made molecular properties is an extremely interesting problem. The present study investigates how key process operating variables (i.e., nutritional and aeration conditions) affect the biomass production rate and the PHB accumulation in the cells and its associated molecular weight distribution. A combined metabolic/polymerization/macroscopic modelling approach, relating the process performance and product quality with the process variables, was developed and validated using an extensive series of experiments and measurements. The model predicts the dynamic evolution of the biomass growth, the polymer accumulation, the consumption of carbon and nitrogen sources and the average molecular weights of the PHB in a bioreactor, under batch and fed-batch operating conditions. The proposed integrated model was used for the model-based optimization of the production of PHB with tailor-made molecular properties in Azohydromonas lata bacteria. The process optimization led to a high intracellular PHB accumulation (up to 95% g of PHB per g of DCW) and the production of different grades (i.e., different molecular weight distributions) of PHB. Copyright © 2011 Elsevier Inc. All rights reserved.

  3. Development of thermophilic tailor-made enzyme mixtures for the bioconversion of agricultural and forest residues

    Directory of Open Access Journals (Sweden)

    Anthi eKarnaouri

    2016-02-01

    Full Text Available Even though the main components of all lignocellulosic feedstocks include cellulose, hemicellulose, as well as the protective lignin matrix, there are some differences in structure, such as in hardwoods and softwoods, which may influence the degradability of the materials. Under this view, various types of biomass might require a minimal set of enzymes that has to be tailor-made. Partially defined complex mixtures that are currently commercially used are not adapted to efficiently degrade different materials, so novel enzyme mixtures have to be customized. Development of these cocktails requires better knowledge about the specific activities involved, in order to optimize hydrolysis. The role of filamentous fungus Myceliophthora thermophila and its complete enzymatic repertoire for the bioconversion of complex carbohydrates has been widely proven. In this study, four core cellulases (MtCBH7, MtCBH6, MtEG5 and MtEG7, in the presence of other four accessory enzymes (mannanase, lytic polyssacharide monooxygenase MtGH61, xylanase, MtFae1a and β-glucosidase MtBGL3, were tested as a 9-component cocktail against one model substrate (phosphoric acid swollen cellulose and four hydrothermally pretreated natural substrates (wheat straw as an agricultural waste, birch and spruce biomass, as forest residues. Synergistic interactions among different enzymes were determined using a suitable design of experiments methodology. The results suggest that for the hydrolysis of the pure substrate (PASC, high proportions of MtEG7 are needed for efficient yields. MtCBH7 and MtEG7 are enzymes of major importance during the hydrolysis of pretreated wheat straw, while MtCBH7 plays a crucial role in case of spruce. Cellobiohydrolases MtCBH6 and MtCBH7 act in combination and are key enzymes for the hydrolysis of the hardwood (birch. Optimum combinations were predicted from suitable statistical models which were able to further increase hydrolysis yields, suggesting that

  4. Short and intense tailor-made notched music training against tinnitus: the tinnitus frequency matters.

    Directory of Open Access Journals (Sweden)

    Henning Teismann

    Full Text Available Tinnitus is one of the most common diseases in industrialized countries. Here, we developed and evaluated a short-term (5 subsequent days and intensive (6 hours/day tailor-made notched music training (TMNMT for patients suffering from chronic, tonal tinnitus. We evaluated (i the TMNMT efficacy in terms of behavioral and magnetoencephalographic outcome measures for two matched patient groups with either low (≤8 kHz, N = 10 or high (>8 kHz, N = 10 tinnitus frequencies, and the (ii persistency of the TMNMT effects over the course of a four weeks post-training phase. The results indicated that the short-term intensive TMNMT took effect in patients with tinnitus frequencies ≤8 kHz: subjective tinnitus loudness, tinnitus-related distress, and tinnitus-related auditory cortex evoked activity were significantly reduced after TMNMT completion. However, in the patients with tinnitus frequencies >8 kHz, significant changes were not observed. Interpreted in their entirety, the results also indicated that the induced changes in auditory cortex evoked neuronal activity and tinnitus loudness were not persistent, encouraging the application of the TMNMT as a longer-term training. The findings are essential in guiding the intended transfer of this neuro-scientific treatment approach into routine clinical practice.

  5. Tailor-made Surgical Guide Reduces Incidence of Outliers of Cup Placement.

    Science.gov (United States)

    Hananouchi, Takehito; Saito, Masanobu; Koyama, Tsuyoshi; Sugano, Nobuhiko; Yoshikawa, Hideki

    2010-04-01

    Malalignment of the cup in total hip arthroplasty (THA) increases the risks of postoperative complications such as neck cup impingement, dislocation, and wear. We asked whether a tailor-made surgical guide based on CT images would reduce the incidence of outliers beyond 10 degrees from preoperatively planned alignment of the cup compared with those without the surgical guide. We prospectively followed 38 patients (38 hips, Group 1) having primary THA with the conventional technique and 31 patients (31 hips, Group 2) using the surgical guide. We designed the guide for Group 2 based on CT images and fixed it to the acetabular edge with a Kirschner wire to indicate the planned cup direction. Postoperative CT images showed the guide reduced the number of outliers compared with the conventional method (Group 1, 23.7%; Group 2, 0%). The surgical guide provided more reliable cup insertion compared with conventional techniques. Level II, therapeutic study. See the Guidelines for Authors for a complete description of levels of evidence.

  6. Tailor-Made Additives for Morphology Control in Molecular Bulk-Heterojunction Photovoltaics

    KAUST Repository

    Graham, Kenneth R.

    2013-01-09

    Tailor-made additives, which are molecules that share the same molecular structure as a parent molecule with only slight structural variations, have previously been demonstrated as a useful means to control crystallization dynamics in solution. For example, tailor-made additives can be added to solutions of a crystallizing parent molecule to alter the crystal growth rate, size, and shape. We apply this strategy as a means to predictably control morphology in molecular bulk-heterojunction (BHJ) photovoltaic cells. Through the use of an asymmetric oligomer substituted with a bulky triisobutylsilyl end group, the morphology of BHJ blends can be controlled resulting in a near doubling (from 1.3 to 2.2%) in power conversion efficiency. The use of tailor-made additives provides promising opportunities for controlling crystallization dynamics, and thereby film morphologies, for many organic electronic devices such as photovoltaics and field-effect transistors. © 2012 American Chemical Society.

  7. Tailor-Made Additives for Morphology Control in Molecular Bulk-Heterojunction Photovoltaics

    KAUST Repository

    Graham, Kenneth R.; Stalder, Romain; Wieruszewski, Patrick M.; Patel, Dinesh G.; Salazar, Danielle H.; Reynolds, John R.

    2013-01-01

    Tailor-made additives, which are molecules that share the same molecular structure as a parent molecule with only slight structural variations, have previously been demonstrated as a useful means to control crystallization dynamics in solution. For example, tailor-made additives can be added to solutions of a crystallizing parent molecule to alter the crystal growth rate, size, and shape. We apply this strategy as a means to predictably control morphology in molecular bulk-heterojunction (BHJ) photovoltaic cells. Through the use of an asymmetric oligomer substituted with a bulky triisobutylsilyl end group, the morphology of BHJ blends can be controlled resulting in a near doubling (from 1.3 to 2.2%) in power conversion efficiency. The use of tailor-made additives provides promising opportunities for controlling crystallization dynamics, and thereby film morphologies, for many organic electronic devices such as photovoltaics and field-effect transistors. © 2012 American Chemical Society.

  8. The thermo-technical optimization in the evaporator by a targeted selection of refractory systems. Calculations and evaluation, installation of a tailor-made refractory system, results from the practice; Waermetechnische Optimierung im Dampferzeuger durch gezielte Auswahl von Feuerfestsystemen. Berechnungen und Bewertungen, Installation des massgeschneiderten Feuerfestsystems, Ergebnisse aus der Praxis

    Energy Technology Data Exchange (ETDEWEB)

    Martin, Karl-Ulrich [Mokesa AG, Birsfelden (Switzerland). Marketing/Verkauf; Hofmans, Erik [ISVAG, Wilrijk (Belgium). Technischer Dienst/Instandhaltung; Kern, Tobias [Mokesa AG, Birsfelden (Switzerland); Hoeff, Jos van der [Mokesa Benelux B.V., Limmen (Netherlands)

    2013-03-01

    The thermo-technical optimization of existing incinerator boilers with the benefit of a stabilised combustion and a low consumption of fossil fuels in order to meet the rules at a temperature of 850 Celsius for a time period of two seconds even at partial load and low-calorific fuel (waste) is state of the art by means of CFD modelling and its successful transformation into the practice with proven and tailor-made refractory systems. The direct, straight and sustainable economical use is in an enhanced throughput of waste materials, a reduced consumption of fuels and thus a conservation of CO{sub 2}. The stabile combustion control is with a poor readjustment is an important and assuring advantage for the operations manager.

  9. Tailor-made finance versus tailor-made care. Can the state strengthen consumer choice in healthcare by reforming the financial structure of long-term care?

    Science.gov (United States)

    Grit, K; de Bont, A

    2010-02-01

    Policy instruments based on the working of markets have been introduced to empower consumers of healthcare. However, it is still not easy to become a critical consumer of healthcare. The aim of this study is to analyse the possibilities of the state to strengthen the position of patients with the aid of a new financial regime, such as personal health budgets. Data were collected through in-depth interviews with executives, managers, professionals and client representatives of six long-term care institutions. With the introduction of individual budgets the responsibility for budgetary control has shifted from the organisational level to the individual level in the caregiver-client relationship. Having more luxurious care on offer necessitates a stronger demarcation of regular care because organisations cannot simultaneously offer extra care as part of the standard care package. New financial instruments have an impact on the culture of receiving and giving care. Distributive justice takes on new meaning with the introduction of financial market mechanisms in healthcare; the distributing principle of 'need' is transformed into the principle of 'economic demand'. Financial instruments not only act as a countervailing power against providers insufficiently client-oriented, but are also used by providers to reinforce their own positions vis-à-vis demanding clients. Tailor-made finance is not the same as tailor-made care.

  10. Effects of a tailor-made exercise program on exercise adherence and health outcomes in patients with knee osteoarthritis: a mixed-methods pilot study.

    Science.gov (United States)

    Lee, Fung-Kam Iris; Lee, Tze-Fan Diana; So, Winnie Kwok-Wei

    2016-01-01

    Previous studies showed that exercise intervention was effective in symptoms control of knee osteoarthritis (OA) but poor intervention adherence reduced the exercise effect. It has been suspected that the design of exercise intervention mainly from the health care professionals' perspective could not address the patients' barriers to exercise. Therefore, a tailor-made exercise program which incorporated the patient's perspective in the design was developed and ready for evaluation. This pilot study estimated the effects of a tailor-made exercise program on exercise adherence and health outcomes, and explored the participants' perception and experience of the program. The intervention of this study was a 4-week community-based group exercise program, which required the participants to attend a 1-hour session each week. Thirty-four older people with knee OA were recruited to the program. Mixed-methods study design was used to estimate the effects of this program and explore the participants' perception and experience of the program. Exercise adherence and performance in return-demonstration of the exercise were assessed at 12 weeks after the program. Disease-specific health status (Western Ontario and McMaster Universities Osteoarthritis Index), general health status (12-item Short Form of the Medical Outcome Study Questionnaire), knee range of motion, muscle strength, and endurance of the lower extremities (Timed-Stands Test) were measured at the beginning of the program and 12 weeks after. Six participants were interviewed individually on the 12th week. Thirty-three participants (75.0±7.3 years) completed the one-group pretest and post-test study. The participants' exercise adherence was 91.4%±14.54%, and their correct performance in return-demonstration was 76.7%±21.75%. Most of the participants' health outcomes significantly improved at posttests except the 12-item Short Form of the Medical Outcome Study Questionnaire physical health summary score. The

  11. The application of tailor-made force fields and molecular dynamics for NMR crystallography: a case study of free base cocaine

    DEFF Research Database (Denmark)

    Li, Xiaozhou; Neumann, Marcus A.; van de Streek, Jacco

    2017-01-01

    of a fully automatically generated tailor-made force field (TMFF) for the dynamic aspects of NMR crystallography is evaluated and compared with existing benchmarks, including static dispersion-corrected density functional theory calculations and the COMPASS force field. The crystal structure of free base...

  12. Tailor-made rehabilitation approach using multiple types of hybrid assistive limb robots for acute stroke patients: A pilot study.

    Science.gov (United States)

    Fukuda, Hiroyuki; Morishita, Takashi; Ogata, Toshiyasu; Saita, Kazuya; Hyakutake, Koichi; Watanabe, Junko; Shiota, Etsuji; Inoue, Tooru

    2016-01-01

    This article investigated the feasibility of a tailor-made neurorehabilitation approach using multiple types of hybrid assistive limb (HAL) robots for acute stroke patients. We investigated the clinical outcomes of patients who underwent rehabilitation using the HAL robots. The Brunnstrom stage, Barthel index (BI), and functional independence measure (FIM) were evaluated at baseline and when patients were transferred to a rehabilitation facility. Scores were compared between the multiple-robot rehabilitation and single-robot rehabilitation groups. Nine hemiplegic acute stroke patients (five men and four women; mean age 59.4 ± 12.5 years; four hemorrhagic stroke and five ischemic stroke) underwent rehabilitation using multiple types of HAL robots for 19.4 ± 12.5 days, and 14 patients (six men and eight women; mean age 63.2 ± 13.9 years; nine hemorrhagic stroke and five ischemic stroke) underwent rehabilitation using a single type of HAL robot for 14.9 ± 8.9 days. The multiple-robot rehabilitation group showed significantly better outcomes in the Brunnstrom stage of the upper extremity, BI, and FIM scores. To the best of the authors' knowledge, this is the first pilot study demonstrating the feasibility of rehabilitation using multiple exoskeleton robots. The tailor-made rehabilitation approach may be useful for the treatment of acute stroke.

  13. Playing and Listening to Tailor-Made Notched Music: Cortical Plasticity Induced by Unimodal and Multimodal Training in Tinnitus Patients

    Directory of Open Access Journals (Sweden)

    Janna Pape

    2014-01-01

    Full Text Available Background. The generation and maintenance of tinnitus are assumed to be based on maladaptive functional cortical reorganization. Listening to modified music, which contains no energy in the range of the individual tinnitus frequency, can inhibit the corresponding neuronal activity in the auditory cortex. Music making has been shown to be a powerful stimulator for brain plasticity, inducing changes in multiple sensory systems. Using magnetoencephalographic (MEG and behavioral measurements we evaluated the cortical plasticity effects of two months of (a active listening to (unisensory versus (b learning to play (multisensory tailor-made notched music in nonmusician tinnitus patients. Taking into account the fact that uni- and multisensory trainings induce different patterns of cortical plasticity we hypothesized that these two protocols will have different affects. Results. Only the active listening (unisensory group showed significant reduction of tinnitus related activity of the middle temporal cortex and an increase in the activity of a tinnitus-coping related posterior parietal area. Conclusions. These findings indicate that active listening to tailor-made notched music induces greater neuroplastic changes in the maladaptively reorganized cortical network of tinnitus patients while additional integration of other sensory modalities during training reduces these neuroplastic effects.

  14. Playing and listening to tailor-made notched music: cortical plasticity induced by unimodal and multimodal training in tinnitus patients.

    Science.gov (United States)

    Pape, Janna; Paraskevopoulos, Evangelos; Bruchmann, Maximilian; Wollbrink, Andreas; Rudack, Claudia; Pantev, Christo

    2014-01-01

    BACKGROUND. The generation and maintenance of tinnitus are assumed to be based on maladaptive functional cortical reorganization. Listening to modified music, which contains no energy in the range of the individual tinnitus frequency, can inhibit the corresponding neuronal activity in the auditory cortex. Music making has been shown to be a powerful stimulator for brain plasticity, inducing changes in multiple sensory systems. Using magnetoencephalographic (MEG) and behavioral measurements we evaluated the cortical plasticity effects of two months of (a) active listening to (unisensory) versus (b) learning to play (multisensory) tailor-made notched music in nonmusician tinnitus patients. Taking into account the fact that uni- and multisensory trainings induce different patterns of cortical plasticity we hypothesized that these two protocols will have different affects. RESULTS. Only the active listening (unisensory) group showed significant reduction of tinnitus related activity of the middle temporal cortex and an increase in the activity of a tinnitus-coping related posterior parietal area. CONCLUSIONS. These findings indicate that active listening to tailor-made notched music induces greater neuroplastic changes in the maladaptively reorganized cortical network of tinnitus patients while additional integration of other sensory modalities during training reduces these neuroplastic effects.

  15. Study protocol: Münster tinnitus randomized controlled clinical trial-2013 based on tailor-made notched music training (TMNMT).

    Science.gov (United States)

    Pantev, Christo; Rudack, Claudia; Stein, Alwina; Wunderlich, Robert; Engell, Alva; Lau, Pia; Wollbrink, Andreas; Shaykevich, Alex

    2014-03-02

    Tinnitus is a result of hyper-activity/hyper-synchrony of auditory neurons coding the tinnitus frequency, which has developed to synchronous mass activity owing the lack of inhibition. We assume that removal of exactly these frequency components from an auditory stimulus will cause the brain to reorganize around tonotopic regions coding the tinnitus frequency. Based on this assumption a novel treatment for tonal tinnitus - tailor-made notched music training (TMNMT) (Proc Natl Acad Sci USA 107:1207-1210, 2010; Ann N Y Acad Sci 1252:253-258, 2012; Frontiers Syst Neurosci 6:50, 2012) has been introduced and will be tested in this clinical trial on a large number of tinnitus patients. A randomized controlled trial (RCT) in parallel group design will be performed in a double-blinded manner. The choice of the intervention we are going to apply is based on two "proof of concept" studies in humans (Proc Natl Acad Sci USA 107:1207-1210, 2010; Ann N Y Acad Sci 1252:253-258, 2012; Frontiers Syst Neurosci 6:50, 2012; PloS One 6(9):e24685, 2011) and on a recent animal study (Front Syst Neurosci 7:21, 2013).The RCT includes 100 participants with chronic, tonal tinnitus who listened to tailor-made notched music (TMNM) for two hours a day for three months. The effect of TMNMT is assessed by the tinnitus handicap questionnaire and visual analogue scales (VAS) measuring perceived tinnitus loudness, distress and handicap. This is the first randomized controlled trial applying TMNMT on a larger number of patients with tonal tinnitus. Our data will verify more securely and reliably the effectiveness of this kind of completely non-invasive and low-cost treatment approach on tonal tinnitus. Current Controlled Trials ISRCTN04840953.

  16. New tailor-made bio-organoclays for the remediation of olive mill waste water

    International Nuclear Information System (INIS)

    Calabrese, Ilaria; Liveri, Maria Liria Turco; Gelardi, Giulia; Merli, Marcello; Sciascia, Luciana; Rytwo, Giora

    2013-01-01

    A systematic study aimed at obtaining new organoclays for the treatment of Olive Mill Waste water (OMW) has been performed. Several organoclays have been prepared by loading different amounts of the biocompatible surfactant Tween20 onto the K10 montmorillonite (MMT). Complementary kinetic and equilibrium studies on the adsorption of the Tween20 onto the MMT have been carried out and the characterization of the new tailor-made bio-materials has been performed by means of the XRD and FT-IR measurements. Finally the prepared bio-organoclays have been successfully applied for the OMW remediation and they proved to be highly effective in decreasing the organic content (OC) to an extent that depends on both the amount of loaded surfactant and the experimental protocols applied

  17. New tailor-made bio-organoclays for the remediation of olive mill waste water

    Science.gov (United States)

    Calabrese, Ilaria; Gelardi, Giulia; Merli, Marcello; Rytwo, Giora; Sciascia, Luciana; Liria Turco Liveri, Maria

    2013-12-01

    A systematic study aimed at obtaining new organoclays for the treatment of Olive Mill Waste water (OMW) has been performed. Several organoclays have been prepared by loading different amounts of the biocompatible surfactant Tween20 onto the K10 montmorillonite (MMT). Complementary kinetic and equilibrium studies on the adsorption of the Tween20 onto the MMT have been carried out and the characterization of the new tailor-made bio-materials has been performed by means of the XRD and FT-IR measurements. Finally the prepared bio-organoclays have been successfully applied for the OMW remediation and they proved to be highly effective in decreasing the organic content (OC) to an extent that depends on both the amount of loaded surfactant and the experimental protocols applied.

  18. Optimizing diesel combustion behaviour with tailor-made fuels from biomass

    Energy Technology Data Exchange (ETDEWEB)

    Kremer, Florian; Heuser, Benedikt [RWTH Aachen Univ. (Germany). Lehrstuhl fuer Verbrennungskraftmaschinen; Klankermayer, Juergen [RWTH Aachen Univ. (Germany). Inst. fuer Technische und Makromolekulare Chemie; Pischinger, Stefan

    2013-06-01

    Modem biofuels offer a vast potential to decrease engine out emissions while at the same time allowing a reduction of greenhouse gases produced from individual mobility. In order to deeply investigate and improve the complete path from biofuel production to combustion, in 2007 the cluster of excellence ''Tailor-Made Fuels from Biomass'' was installed at RWTH Aachen University. Since the start of the work in the cluster a whole variety of possible fuel candidates were identified and investigated, eventually leading to the definition of 2-methyltetrahydrofurane (2-MTHF) as a tailor-made biofuel for passenger car diesel engines. With 2-MTHF, a nearly soot-free combustion can be realized. This soot-free combustion behavior can partially be explained by the low self-ignition tendency and the therefore observed long ignition delays. Hereby, a good mixture preparation can be realized. This long ignition delay also results in high HC- and CO emissions, though, which are partially accompanied by increased noise emissions. In this work, the addition of di-n-butylether (DNBE) to 2-MTHF to reduce the described disadvantages will be analyzed. DNBE, a fuel that can be obtained via a reaction pathway defined in TMFB, is characterized by an extremely high Cetane number (CN- 100) and therefore very high self-ignitability. The effects of different mixtures of DNBE and 2-MTHF from 0% to 100% especially on the HC- and CO- and noise emissions will be carefully analyzed. In addition, the overall emission performance will be compared to standard EN590 Diesel as reference fuel. The results show that an adapted addition of DNBE to 2-MTHF can lead to a significant reduction of HC-, CO- and noise emissions while not sacrificing the benefits gained from the 2-MTHF's long ignition delays with regard to the particulate emissions. It can be proven that the use of two tailored biofuels with different self-ignitability such as 2-MTHF and DNBE allows to tailor the

  19. Tinnitus therapy using tailor-made notched music delivered via a smartphone application and Ginko combined treatment: A pilot study.

    Science.gov (United States)

    Kim, So Young; Chang, Mun Young; Hong, Min; Yoo, Sun-Gil; Oh, Dongik; Park, Moo Kyun

    2017-10-01

    Notched music therapy has been suggested to be effective for relieving tinnitus. We have developed a smartphone application using tailor-made notched music for tinnitus patients. This study aimed to evaluate the effect of this smartphone application on reducing tinnitus. In addition, we investigated the predictive factors for tinnitus treatment outcome using this smartphone application. A total of 26 patients who were chronically distressed by tinnitus with a ≥18 Tinnitus Handicap Inventory (THI) score were recruited from March 2013 to March 2015 (National Clinical Trial (NCT) Identifier Number 01663467). Patients were instructed to listen to tailor-made notched music through our smartphone application for 30-60min per day and were prescribed Ginkgo biloba for 3 months. Treatment outcome was evaluated using the THI, a visual analogue scale that measures the effects of tinnitus in terms of loudness, noticeable time, annoyance, and disruption of daily life. Demographic data, including age, sex, duration of tinnitus, and pre-treatment scores on questionnaires such as the Beck Depression Inventory (BDI), State Trait Anxiety Inventory (TAI), and Pittsburgh Sleep Quality Index (PSQI) scores were compared between the effective and non-effective groups according to the differences between their pre- and post-treatment THI scores. Smartphone application-delivered notched music therapy and Ginko combined treatment improved the THI score from 33.9±18.9 to 23.1±15.2; the effect was particularly marked for the emotional score of the THI. Improvement in the THI score was positively correlated with the initial THI score (P=0.001, adjusted estimated value=0.49, 95% confidence interval=0.25-0.73). Chronic tinnitus patients who underwent smartphone application-delivered notched music therapy and Ginko combined treatment showed improved THI scores, particularly the emotional score of the THI. A smartphone application-delivered therapy and Ginko combined treatment may be more

  20. Energy conservation through behavioral change. Examining the effectiveness of a tailor-made approach

    Energy Technology Data Exchange (ETDEWEB)

    Abrahamse, W.

    2007-12-06

    Households constitute an important target group when it comes to encouraging energy conservation. This dissertation provides an overview of the effectiveness of interventions aimed at encouraging households to reduce their energy use through behavioral changes. It also provides more insight into the factors related to household energy use and conservation. Tailored interventions in particular appear to be effective in reducing energy consumption. Households were given tailored information about energy saving measures they could apply. They were asked to try and save 5% energy and the website indicated how much energy they could save with each measure to attain that goal. Households also received feedback about their energy savings. Households who received the combination of tailored information, goal setting and tailored feedback via the Internet saved 5%, while households in a control group used more energy. Households had adopted more energy-saving measures and had more knowledge of energy conservation, compared to the control group. Also, household energy consumption appeared to be mainly related to socio-demographic variables, such as income and household size. Energy savings appeared to be mainly related to individual factors like perceived behavioral control. If the aim is to encourage households to adopt more sustainable lifestyles, it is important to provide them with more insight into which energy saving options are most effective for them to conserve energy. In view of the annual energy reduction targets set by the Dutch government, a tailor-made approach via the Internet can be an important step in that direction.

  1. Effect of trehalose coating on basic fibroblast growth factor release from tailor-made bone implants.

    Science.gov (United States)

    Choi, Sungjin; Lee, Jongil; Igawa, Kazuyo; Suzuki, Shigeki; Mochizuki, Manabu; Nishimura, Ryohei; Chung, Ung-il; Sasaki, Nobuo

    2011-12-01

    Artificial bone implants are often incorporated with osteoinductive factors to facilitate early bone regeneration. Calcium phosphate, the main component in artificial bone implants, strongly binds these factors, and in a few cases, the incorporated proteins are not released from the implant under conditions of physiological pH, thereby leading to reduction in their osteoinductivity. In this study, we coated tailor-made bone implants with trehalose to facilitate the release of basic fibroblast growth factor (bFGF). In an in vitro study, mouse osteoblastic cells were separately cultured for 48 hr in a medium with a untreated implant (T-), trehalose-coated implant (T+), bFGF-incorporated implant (FT-), and bFGF-incorporated implant with trehalose coating (FT+). In the FT+ group, cell viability was significantly higher than that in the other groups (Pbone implant without affecting the crystallinity or the mechanical strength of the artificial bone implant. These results suggest that coating artificial bone implants with trehalose could limit the binding of bFGF to calcium phosphate.

  2. Systematic Approach to Design Tailor Made Fuel Blends That Meets ASTM Standards

    DEFF Research Database (Denmark)

    Intikhab, S.; Kalakul, Sawitree; H., Choudhury

    2015-01-01

    point, vapor pressure, and heat content were determined using analytical instruments according to their respective American Society for Testing and Materials (ASTM) standards. Most of the properties complied well with the industry standards. However, model gasoline had a comparatively low RVP....... On the other hand, model diesel had a significantly higher cloud point and pour point than what is recommended. This deviation will have an impact on the cold flow properties of the fuels. For both fuels, different additives along with their composition have also been determined using the same computational...

  3. Tailor-made cell patterning using a near-infrared-responsive composite gel composed of agarose and carbon nanotubes

    International Nuclear Information System (INIS)

    Koga, Haruka; Nakazawa, Kohji; Sada, Takao; Fujigaya, Tsuyohiko; Nakashima, Naotoshi

    2013-01-01

    Micropatterning is useful for regulating culture environments. We developed a highly efficient near-infrared-(NIR)-responsive gel and established a new technique that enables cell patterning by NIR irradiation. As a new culture substratum, we designed a tissue culture plate that was coated with a composite gel composed of agarose and carbon nanotubes (CNTs). A culture plate coated with agarose only showed no response to NIR irradiation. In contrast, NIR laser irradiation induced heat generation by CNTs; this permitted local solation of the CNT/agarose gel, and consequently, selective cell-adhesive regions were exposed on the tissue culture plate. The solation area was controlled by the NIR intensity, magnification of the object lens and CNT concentration in the gel. Furthermore, we formed circular patterns of HeLa cells and linear patterns of 3T3 cells on the same culture plate through selective and stepwise NIR irradiation of the CNT/agarose gel, and we also demonstrated that individual 3T3 cells migrated along a linear path formed on the CNT/agarose gel by NIR irradiation. These results indicate that our technique is useful for tailor-made cell patterning of stepwise and/or complex cell patterns, which has various biological applications such as stepwise co-culture and the study of cell migration. (paper)

  4. Tailor-made diagnosis and therapy of breast cancer for familial predisposed women

    International Nuclear Information System (INIS)

    Frankenberg-Schwager, M.

    2003-01-01

    Familial predisposed women heterozygous for an inherited mutation in a tumor suppressor gene (such as BRCA1+/- or BRCA2+/-) are at a higher risk for loss of tumor suppressor gene function than normal women and may develop breast cancer (BRCA-/-). For early detection of breast cancer these women are advised to start mammography screening at an early age and at annual intervals. Mammography X-rays were shown to enhance neoplastic transformation and mutation in human cell lines. Based on the mutation data it is estimated that a single mammogram confers loss of BRCA function (BRCA-/-) in at least several thousand breast epithelial target cells of a predisposed woman. BRCA1 and BRCA2 genes belong to a group of genes required for the error-free repair of DNA double-strand breaks (DSBs) by homologous recombination. This pathway is impaired in BRCA1-/- or BRCA2-/- cells and DSBs are channeled into potentially error-prone pathways such as non-homologous end joining (NHEJ) and single-strand annealing (SSA). BRCA-deficient cells show a mutator phenotype characterized by an increasing genetic instability. This seems to be the mechanistic explanation for the enhanced risk of breast cancer in predisposed women. Consequently, for the recommended early and frequent screening of predisposed women the induction of DSBs by mammography X-rays should be avoided. Instead, a diagnostic tool not associated with radiation, such as NM imaging, is preferable, which also provides a significantly higher accuracy than conventional imaging to detect breast cancer in high-risk women. BRCA-deficient cells are extremely sensitive to DNA-DNA crosslinking agents. Experimental evidence suggests that repair of DNA interstrand crosslinks occurs in the S-phase of the cell cycle and DSBs are formed as repair intermediates. These can be repaired by homologous recombination between sister chromatids in normal but not in BRCA-deficient cells. Consequently, DNA crosslinking agents appear to be the tailor-made

  5. The effect of different dopant concentration of tailor-made silica fibers in radiotherapy dosimetry

    Science.gov (United States)

    Begum, Mahfuza; Mizanur Rahman, A. K. M.; Zubair, H. T.; Abdul-Rashid, H. A.; Yusoff, Z.; Begum, Mahbuba; Alkhorayef, M.; Alzimami, K.; Bradley, D. A.

    2017-12-01

    In thermoluminescence (TL) material dopant concentration has an important effect on their characteristics as a ;radiation-sensor;. The study investigates dosimetric properties of four different concentration (4 mol%, 5 mol%, 7 mol% and 25 mol%) tailor-made Ge-doped silica fibers. The intention is to seek development of alternative TL materials that offer exceptional advantages over existing passive systems of dosimetry, including improved spatial resolution, a water impervious nature and low cost. Photon beams (6 MV and 10 MV) from a clinical linear accelerator were used for irradiation of the fiber samples over radiation therapy doses, ranging from 0.5 Gy to 8 Gy. SEM-EDX analysis was also performed to investigate the homogeneity of distribution of Ge dopant concentration from the fiber samples. The results of measurement were also compared with two of the more commonly used standard TLDs, TLD-100 (LiF: Mg,Ti-7.5% 6LiF) and TLD-700 ((7LiF: Mg,Ti-99.9%7LiF) chips respectively. The TL intensity of the fiber samples was found to strongly depend on Ge dopant concentration, with samples showing enhanced TL yields with decreasing Ge dopant concentration. 4 mol% Ge-doped silica fiber provided the greatest response whereas the 25 mol% samples showed the least, indicative of the well-known concentration quenching effects All fiber TLDs provided linear dose response over the delivered radiotherapy dose-range, the fibers also showing a weak dependence on photon beam energies in comparing the TL yields at 6 and 10 MV. The fading behavior of the different concentration Ge doped TLD-materials were also measured over a period of thirty (30) days subsequent to irradiation. The relative sensitivity of the samples with respect to standard TLD-100 were found to be 0.37, 0.26, 0.13 and 0.02 in respect of the 4, 5, 7 and 25 mol% fibers. The primary dosimetry peak, which was by far the most prominent of any other feature covered by the glow curve, was found to be around 244 °C using

  6. From tailor-made to ready-to-wear meningococcal B vaccines: longitudinal study of a clonal meningococcal B outbreak.

    Science.gov (United States)

    Caron, François; du Châtelet, Isabelle Parent; Leroy, Jean-Philippe; Ruckly, Corinne; Blanchard, Myriam; Bohic, Nicole; Massy, Nathalie; Morer, Isabelle; Floret, Daniel; Delbos, Valérie; Hong, Eva; Révillion, Martin; Berthelot, Gilles; Lemée, Ludovic; Deghmane, Ala-Eddine; Bénichou, Jacques; Lévy-Bruhl, Daniel; Taha, Muhamed-Kheir

    2011-06-01

    Outer-membrane-vesicle vaccines for meningococcal B outbreaks are complex and time consuming to develop. We studied the use of already available vaccine to control an outbreak caused by a genetically close strain. From 2006 to 2009, all individuals younger than 20 years living in the region of Normandy, France, in which an outbreak caused by a B:14:P1.7,16 strain occurred, were eligible to receive MenBvac, a Norwegian vaccine designed 20 years earlier against a strain sharing the same serosubtype (B:15:P1.7,16). The immunogenicity (in a randomly selected cohort of 400 children aged 1-5 years), safety, and epidemiological effect of the vaccination were assessed. 26,014 individuals were eligible to receive the vaccine. Shortage of vaccine production prompted start of the campaign in the highest incidence groups (1-5 years). 16,709 (64%) received a complete vaccination schedule of whom 13,589 (81%) received a 2+1 dose schedule (week 0, week 6, and month 8). At 6 weeks after the third dose, of 235 vaccinees for whom samples were available, 206 (88%) had a seroresponse, and 108 (56 %) of 193 had a seroresponse at 15 months. These results were similar to those described for tailor-made vaccines and their homologous strain. Only previously described adverse effects occurred. The incidence of B:14:P1.7,16 cases decreased significantly in the vaccine targeted population after the primary vaccination period (from 31·6 per 100,000 to 5·9 per 100,000; p=0·001). The ready-to-wear approach is reliable if epidemic and vaccine strains are genetically close. Other meningococcal B clonal outbreaks might benefit from this strategy; and previously described outer-membrane-vesicle vaccines can be effective against various strains. French Ministry of Health. Copyright © 2011 Elsevier Ltd. All rights reserved.

  7. Combining transcranial direct current stimulation and tailor-made notched music training to decrease tinnitus-related distress--a pilot study.

    Directory of Open Access Journals (Sweden)

    Henning Teismann

    Full Text Available The central auditory system has a crucial role in tinnitus generation and maintenance. Curative treatments for tinnitus do not yet exist. However, recent attempts in the therapeutic application of both acoustic stimulation/training procedures and electric/magnetic brain stimulation techniques have yielded promising results. Here, for the first time we combined tailor-made notched music training (TMNMT with transcranial direct current stimulation (tDCS in an effort to modulate TMNMT efficacy in the treatment of 32 patients with tonal tinnitus and without severe hearing loss. TMNMT is characterized by regular listening to so-called notched music, which is generated by digitally removing the frequency band of one octave width centered at the individual tinnitus frequency. TMNMT was applied for 10 subsequent days (2.5 hours of daily treatment. During the initial 5 days of treatment and the initial 30 minutes of TMNMT sessions, tDCS (current strength: 2 mA; anodal (N = 10 vs. cathodal (N = 11 vs. sham (N = 11 groups was applied simultaneously. The active electrode was placed on the head surface over left auditory cortex; the reference electrode was put over right supra-orbital cortex. To evaluate treatment outcome, tinnitus-related distress and perceived tinnitus loudness were assessed using standardized tinnitus questionnaires and a visual analogue scale. The results showed a significant treatment effect reflected in the Tinnitus Handicap Questionnaire that was largest after 5 days of treatment. This effect remained significant at the end of follow-up 31 days after treatment cessation. Crucially, tDCS did not significantly modulate treatment efficacy--it did not make a difference whether anodal, cathodal, or sham tDCS was applied. Possible explanations for the findings and functional modifications of the experimental design for future studies (e.g. the selection of control conditions are discussed.

  8. Advances in directed monooxygenase evolution : from diversity generation and flow cytometry screening to tailor-made monooxygenases

    OpenAIRE

    Ruff, Anna Joëlle

    2012-01-01

    Directed Evolution became a powerful tool for proteins engineers to generate tailor-made biocatalyst. Directed protein evolution consist of the following three consecutive main steps, which are performed in iterative cycles; Step 1 the gene diversity generation, Step 2 the screening for improved variants and Step 3 the isolation of gene encoding for improved proteins. In this thesis, methodological advancements in the two key steps of the directed evolution, the diversity generation (SeSaM me...

  9. An approach to the construction of tailor-made amphiphilic peptides that strongly and selectively bind to hairpin RNA targets.

    Science.gov (United States)

    Lee, Su Jin; Hyun, Soonsil; Kieft, Jeffrey S; Yu, Jaehoon

    2009-02-18

    strategies that can be used to prepare peptides that both strongly and selectively target hairpin RNAs. Specifically, the findings indicate that tailor-made amphiphilic peptide ligands against certain hairpin RNAs can be obtained if the RNA target possesses a deep groove in which both the hydrophobic and hydrophilic spheres of the peptide interact.

  10. Tailor-made ezrin actin binding domain to probe its interaction with actin in-vitro.

    Directory of Open Access Journals (Sweden)

    Rohini Shrivastava

    Full Text Available Ezrin, a member of the ERM (Ezrin/Radixin/Moesin protein family, is an Actin-plasma membrane linker protein mediating cellular integrity and function. In-vivo study of such interactions is a complex task due to the presence of a large number of endogenous binding partners for both Ezrin and Actin. Further, C-terminal actin binding capacity of the full length Ezrin is naturally shielded by its N-terminal, and only rendered active in the presence of Phosphatidylinositol bisphosphate (PIP2 or phosphorylation at the C-terminal threonine. Here, we demonstrate a strategy for the design, expression and purification of constructs, combining the Ezrin C-terminal actin binding domain, with functional elements such as fusion tags and fluorescence tags to facilitate purification and fluorescence microscopy based studies. For the first time, internal His tag was employed for purification of Ezrin actin binding domain based on in-silico modeling. The functionality (Ezrin-actin interaction of these constructs was successfully demonstrated by using Total Internal Reflection Fluorescence Microscopy. This design can be extended to other members of the ERM family as well.

  11. Functional Polymer Opals and Porous Materials by Shear-Induced Assembly of Tailor-Made Particles.

    Science.gov (United States)

    Gallei, Markus

    2018-02-01

    Photonic band-gap materials attract enormous attention as potential candidates for a steadily increasing variety of applications. Based on the preparation of easily scalable monodisperse colloids, such optically attractive photonic materials can be prepared by an inexpensive and convenient bottom-up process. Artificial polymer opals can be prepared by shear-induced assembly of core/shell particles, yielding reversibly stretch-tunable materials with intriguing structural colors. This feature article highlights recent developments of core/shell particle design and shear-induced opal formation with focus on the combination of hard and soft materials as well as crosslinking strategies. Structure formation of opal materials relies on both the tailored core/shell architecture and the parameters for polymer processing. The emphasis of this feature article is on elucidating the particle design and incorporation of addressable moieties, i.e., stimuli-responsive polymers as well as elaborated crosslinking strategies for the preparation of smart (inverse) opal films, inorganic/organic opals, and ceramic precursors by shear-induced ordering. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  12. Highly ordered porous alumina with tailor-made pore structures fabricated by pulse anodization

    International Nuclear Information System (INIS)

    Lee, Woo; Kim, Jae-Cheon

    2010-01-01

    A new anodization method for the preparation of nanoporous anodic aluminum oxide (AAO) with pattern-addressed pore structure was developed. The approach is based on pulse anodization of aluminum employing a series of potential waves that consist of two or more different pulses with designated periods and amplitudes, and provides unique tailoring capability of the internal pore structure of anodic alumina. Pores of the resulting AAOs exhibit a high degree of directional coherency along the pore axes without branching, and thus are suitable for fabricating novel nanowires or nanotubes, whose diameter modulation patterns are predefined by the internal pore geometry of AAO. It is found from microscopic analysis on pulse anodized AAOs that the effective electric field strength at the pore base is a key controlling parameter, governing not only the size of pores, but also the detailed geometry of the barrier oxide layer.

  13. Raising the shields: PCR in the presence of metallic surfaces protected by tailor-made coatings.

    Science.gov (United States)

    Scherag, Frank D; Brandstetter, Thomas; Rühe, Jürgen

    2014-10-01

    The implementation of PCR reactions in the presence of metallic surfaces is interesting for the generation of novel bioanalytical devices, because metals exhibit high mechanical stability, good thermal conductivity, and flexibility during deformation. However, metallic substrates are usually non-compatible with enzymatic reactions such as PCR due to poisoning of the active center of the enzyme or nonspecific adsorption of the enzymeto the metal surface, which could result in protein denaturation. We present a method for the generation of polymer coatings on metallic surfaces which are designed to minimize protein adsorption and also prevent the release of metal ions. These coatings consist of three layers covalently linked to each other; a self-assembled monolayer to promote adhesion, a photochemically generated barrier layer and a photochemically generated hydrogel. The coatings can be deposited onto aluminum, stainless steel, gold and copper surfaces. We compare PCR efficiencies in the presence of bare metallic surfaces with those of surfaces treated with the novel coating system. Copyright © 2014 Elsevier B.V. All rights reserved.

  14. Dopant concentration and thermoluminescence (TL) properties of tailor-made Ge-doped SiO2 fibres

    International Nuclear Information System (INIS)

    Zahaimi, Nurul Arina; Ooi Abdullah, Mohd Haris Ridzuan; Zin, Hafiz; Abdul Rahman, Ahmad Lutfi; Hashim, Suhairul; Saripan, Mohd Iqbal; Paul, Mukul Chandra; Bradley, D.A.; Abdul Rahman, Ahmad Taufek

    2014-01-01

    Study focuses on characterisation of diverse concentrations of Ge-doped SiO 2 fibre as a potential thermoluminescence (TL) system for radiotherapy dosimetry. Irradiations were made using a linear accelerator providing 6 MV and 10 MV photon beams. Investigation has been done on various doped core diameter Ge-doped SiO 2 glass fibres such as commercial telecommunication fibres of 8 µm and 9 µm (CorActive High Tech, Canada), tailor-made fibres of 23 and 50 µm produced by the Central Glass and Ceramic Research Institute Kolkata, and tailor-made fibres of 11 µm produced by the University of Malaya Photonics Research Centre. The fibres have been characterised for TL sensitivity, reproducibility, dose- and energy-dependence. The area under the TL glow curve increases with increasing core diameter. For repeat irradiations at a fixed dose the dosimeter produces a flat response better than 4% (1SD) of the mean of the TL distribution. Minimal TL signal fading was found, less than 0.5% per day post irradiation. Linearity of TL has been observed with a correlation coefficient (r 2 ) of better than 0.980 (at 95% confidence level). For particular dopant concentrations, the least square fits show the change in TL yield, in counts per second per unit mass, obtained from 50 µm core diameter fibres irradiated at 6 MV of photon to be 8 times greater than that of 8 µm core diameter fibre. With respect to energy response, the TL yield at 10 MV decreases by∼5% compared to that at 6 MV, primarily due to the lower mass energy absorption coefficient at higher photon energy. These early results indicate that selectively screened fibres can be developed into a promising TL system, offering high spatial resolution capability and, with this, verification of complex radiotherapy dose distributions. - Highlights: • We examined the TL glow curve intensity for various diameter sizes of germanium doped silica glass fibre. • TL sensitivity increased with the increase of fibre core

  15. Highly selective oxidation of styrene to benzaldehyde over a tailor-made cobalt oxide encapsulated zeolite catalyst.

    Science.gov (United States)

    Liu, Jiangyong; Wang, Zihao; Jian, Panming; Jian, Ruiqi

    2018-05-01

    A tailor-made catalyst with cobalt oxide particles encapsulated into ZSM-5 zeolites (Co 3 O 4 @HZSM-5) was prepared via a hydrothermal method with the conventional impregnated Co 3 O 4 /SiO 2 catalyst as the precursor and Si source. Various characterization results show that the Co 3 O 4 @HZSM-5 catalyst has well-organized structure with Co 3 O 4 particles compatibly encapsulated in the zeolite crystals. The Co 3 O 4 @HZSM-5 catalyst was employed as an efficient catalyst for the selective oxidation of styrene to benzaldehyde with hydrogen peroxide as a green and economic oxidant. The effect of various reaction conditions including reaction time, reaction temperature, different kinds of solvents, styrene/H 2 O 2 molar ratio and catalyst dosage on the catalytic performance were systematically investigated. Under the optimized reaction condition, the yield of benzaldehyde can achieve 78.9% with 96.8% styrene conversion and 81.5% benzaldehyde selectivity. Such an excellent catalytic performance can be attributed to the synergistic effect between the confined reaction environment and the proper acidic property. In addition, the reaction mechanism with Co 3 O 4 @HZSM-5 as the catalyst for the selective oxidation of styrene to benzaldehyde was reasonably proposed. Copyright © 2018 Elsevier Inc. All rights reserved.

  16. Simultaneous biodegradation of three mononitrophenol isomers by a tailor-made microbial consortium immobilized in sequential batch reactors.

    Science.gov (United States)

    Fu, H; Zhang, J-J; Xu, Y; Chao, H-J; Zhou, N-Y

    2017-03-01

    The ortho-nitrophenol (ONP)-utilizing Alcaligenes sp. strain NyZ215, meta-nitrophenol (MNP)-utilizing Cupriavidus necator JMP134 and para-nitrophenol (PNP)-utilizing Pseudomonas sp. strain WBC-3 were assembled as a consortium to degrade three nitrophenol isomers in sequential batch reactors. Pilot test was conducted in flasks to demonstrate that a mixture of three mononitrophenols at 0·5 mol l -1 each could be mineralized by this microbial consortium within 84 h. Interestingly, neither ONP nor MNP was degraded until PNP was almost consumed by strain WBC-3. By immobilizing this consortium into polyurethane cubes, all three mononitrophenols were continuously degraded in lab-scale sequential reactors for six batch cycles over 18 days. Total concentrations of ONP, MMP and PNP that were degraded were 2·8, 1·5 and 2·3 mol l -1 during this time course respectively. Quantitative real-time PCR analysis showed that each member in the microbial consortium was relatively stable during the entire degradation process. This study provides a novel approach to treat polluted water, particularly with a mixture of co-existing isomers. Nitroaromatic compounds are readily spread in the environment and pose great potential toxicity concerns. Here, we report the simultaneous degradation of three isomers of mononitrophenol in a single system by employing a consortium of three bacteria, both in flasks and lab-scale sequential batch reactors. The results demonstrate that simultaneous biodegradation of three mononitrophenol isomers can be achieved by a tailor-made microbial consortium immobilized in sequential batch reactors, providing a pilot study for a novel approach for the bioremediation of mixed pollutants, especially isomers present in wastewater. © 2016 The Society for Applied Microbiology.

  17. Impact of Spectral Notch Width on Neurophysiological Plasticity and Clinical Effectiveness of the Tailor-Made Notched Music Training.

    Directory of Open Access Journals (Sweden)

    Robert Wunderlich

    Full Text Available Tinnitus, the ringing in the ears that is unrelated to any external source, causes a significant loss in quality of life, involving sleep disturbance and depression for 1 to 3% of the general population. While in the first place tinnitus may be triggered by damage to the inner ear cells, the neural generators of subjective tinnitus are located in central regions of the nervous system. A loss of lateral inhibition, tonotopical reorganization and a gain-increase in response to the sensory deprivation result in hypersensitivity and hyperactivity in certain regions of the auditory cortex. In the tailor-made notched music training (TMNMT patients listen to music from which the frequency spectrum of the tinnitus has been removed. This evokes strong lateral inhibition from neurons tuned to adjacent frequencies onto the neurons involved in the tinnitus percept. A reduction of tinnitus loudness and tinnitus-related neural activity was achieved with TMNMT in previous studies. As the effect of lateral inhibition depends on the bandwidth of the notch, in the current study we altered the notch width to find the most effective notch width for TMNMT. We compared 1-octave notch width with ½-octave and ¼-octave. Participants chose their favorite music for the training that included three month of two hours daily listening. The outcome was measured by means of standardized questionnaires and magnetoencephalography. We found a general reduction of tinnitus distress in all administered tinnitus questionnaires after the training. Additionally, tinnitus-related neural activity was reduced after the training. Nevertheless, notch width did not have an influence on the behavioral or neural effects of TMNMT. This could be due to a non-linear resolution of lateral inhibition in high frequencies.

  18. Physical structure and absorption properties of tailor-made porous starch granules produced by selected amylolytic enzymes.

    Directory of Open Access Journals (Sweden)

    Yi-Seul Jung

    Full Text Available Porous starch granules (PSGs with various pores and cavity sizes were prepared by amylolysis enzymes. The greatest hydrolysis rate on corn starch granule was observed with α-amylase, followed by gluco- and β-amylases. Temperature increase enhanced glucoamylase reaction rate more drastically than other enzyme treatments. Final hydrolysis level with glucoamylase reached to 66.9%, close to 67.5% of α-amylolysis. The α-amylase-treated PSGs displayed the greatest pore size and ratio of cavity-to-granule diameters. Gelatinization onset temperatures of PSGs increased to 72.1 (α-, 68.7 (β-, and 68.1°C (gluco-amylolysis after 8 h; enthalpy changes of β- and gluco-amylase-treated PSGs increased to 13.4, and 13.1 J/g but α-amylase-treated one showed slightly reduced value of 8.5 J/g. Water holding capacities of PSGs were 209.7 (α-, 94.6 (β-, and 133.8% (gluco-amylolysis, and the untreated control had 89.1%; oil holding capacities of them showed 304.5, 182.7, and 211.5%, respectively, while the untreated control had 161.8%. Thus, enzyme types and their reaction conditions can be applied to generate desirable cavity and pore sizes in starch granules. This biocatalytic approach could contribute to develop tailor-made PSGs with distinct internal structure for specific uses in wide range of food, pharmaceutical and other industrial applications.

  19. Enhancing inhibition-induced plasticity in tinnitus--spectral energy contrasts in tailor-made notched music matter.

    Directory of Open Access Journals (Sweden)

    Alwina Stein

    Full Text Available Chronic tinnitus seems to be caused by reduced inhibition among frequency selective neurons in the auditory cortex. One possibility to reduce tinnitus perception is to induce inhibition onto over-activated neurons representing the tinnitus frequency via tailor-made notched music (TMNM. Since lateral inhibition is modifiable by spectral energy contrasts, the question arises if the effects of inhibition-induced plasticity can be enhanced by introducing increased spectral energy contrasts (ISEC in TMNM. Eighteen participants suffering from chronic tonal tinnitus, pseudo randomly assigned to either a classical TMNM or an ISEC-TMNM group, listened to notched music for three hours on three consecutive days. The music was filtered for both groups by introducing a notch filter centered at the individual tinnitus frequency. For the ISEC-TMNM group a frequency bandwidth of 3/8 octaves on each side of the notch was amplified, additionally, by about 20 dB. Before and after each music exposure, participants rated their subjectively perceived tinnitus loudness on a visual analog scale. During the magnetoencephalographic recordings, participants were stimulated with either a reference tone of 500 Hz or a test tone with a carrier frequency representing the individual tinnitus pitch. Perceived tinnitus loudness was significantly reduced after TMNM exposure, though TMNM type did not influence the loudness ratings. Tinnitus related neural activity in the N1m time window and in the so called tinnitus network comprising temporal, parietal and frontal regions was reduced after TMNM exposure. The ISEC-TMNM group revealed even enhanced inhibition-induced plasticity in a temporal and a frontal cortical area. Overall, inhibition of tinnitus related neural activity could be strengthened in people affected with tinnitus by increasing spectral energy contrast in TMNM, confirming the concepts of inhibition-induced plasticity via TMNM and spectral energy contrasts.

  20. Physical structure and absorption properties of tailor-made porous starch granules produced by selected amylolytic enzymes

    Science.gov (United States)

    Jung, Yi-seul; Lee, Byung-Hoo

    2017-01-01

    Porous starch granules (PSGs) with various pores and cavity sizes were prepared by amylolysis enzymes. The greatest hydrolysis rate on corn starch granule was observed with α-amylase, followed by gluco- and β-amylases. Temperature increase enhanced glucoamylase reaction rate more drastically than other enzyme treatments. Final hydrolysis level with glucoamylase reached to 66.9%, close to 67.5% of α-amylolysis. The α-amylase-treated PSGs displayed the greatest pore size and ratio of cavity-to-granule diameters. Gelatinization onset temperatures of PSGs increased to 72.1 (α-), 68.7 (β-), and 68.1°C (gluco-amylolysis) after 8 h; enthalpy changes of β- and gluco-amylase-treated PSGs increased to 13.4, and 13.1 J/g but α-amylase-treated one showed slightly reduced value of 8.5 J/g. Water holding capacities of PSGs were 209.7 (α-), 94.6 (β-), and 133.8% (gluco-amylolysis), and the untreated control had 89.1%; oil holding capacities of them showed 304.5, 182.7, and 211.5%, respectively, while the untreated control had 161.8%. Thus, enzyme types and their reaction conditions can be applied to generate desirable cavity and pore sizes in starch granules. This biocatalytic approach could contribute to develop tailor-made PSGs with distinct internal structure for specific uses in wide range of food, pharmaceutical and other industrial applications. PMID:28727742

  1. TAILOR-MADE BIOCATALYSTS: COMBINING THERMODYNAMICS, ORGANIC SYNTHESIS, MOLECULAR BIOLOGY, BIOCHEMISTRY AND MICROBIOLOGY FOR THE DESIGN OF ENZYME SELECTIONS

    Directory of Open Access Journals (Sweden)

    Jean-Luc Jestin

    2012-09-01

    A second link was created between enzymes and their products. By making use of the chelate effect and of Inovirus particles as a chemical, affinity chromatography for the reaction product is then sufficient to isolate among 106 to 1011 proteins and their genes, the rare ones coding for catalysts of interest. The strategy for the parallel processing of information on the catalytic activity of variants from a large protein repertoire is highlighted in this review.

  2. Understanding and control of nucleation, growth, habit, dissolution and structure of two- and three-dimensional crystals using 'Tailor-made' auxiliaries

    International Nuclear Information System (INIS)

    Weissbuch, I.; Popovitz-Biro, R.; Lahav, M.; Leiserowitz, L.

    1995-01-01

    Tailor-made auxiliaries for the control of nucleation and growth of molecular crystals may be classified into two broad categories: inhibitors and promoters. Tailor-made inhibitors of crystal growth can be used for a variety of purposes, which include morphological engineering and etching, reduction of crystal symmetry, assignment of absolute structure of chiral molecules and polar crystals, elucidation of the effect of solvent on crystal growth, and crystallization of a desired polymorph. As for crystal growth promoters, monolayers of amphiphilic molecules on water have been used to induce the growth of a variety of three-dimensional crystals at the monolayer-solution interface by means of structural match, molecular complementarity or electrostatic interaction. A particular focus is made on the induced nucleation of ice by monolayers of water-insoluble aliphatic alcohols. The two-dimensional crystalline structures of such monolayers have been studied by grazing incidence X-ray diffraction. It has become possible to monitor, by this method, the growth, dissolution and structure of self-aggregated crystalline monolayers, and indeed multilayers, affected by the interaction of solvent molecules in the aqueous subphase with the amphiphilic headgroups, and by the use of tailor-made amphiphilic additives. (orig.)

  3. Influence of fuel properties on fundamental spray characteristics and soot emissions using different tailor-made fuels from biomass

    International Nuclear Information System (INIS)

    García, Antonio; Monsalve-Serrano, Javier; Heuser, Benedikt; Jakob, Markus; Kremer, Florian; Pischinger, Stefan

    2016-01-01

    Highlights: • TMFB show clear potential to reduce soot emissions under mixing-controlled combustion. • The larger lift-off-length of 2-MTHF and 1-octanol promotes soot emissions reduction. • Oxidation process governs the improved soot emissions of DNBE. - Abstract: This work evaluates the potential of some new biomass-derived fuels as candidates for compression ignition operation. Thus, fundamental spray characteristics related to fuel vaporization and fuel/air mixing process for 2-Methyltetrahydrofuran, Di-n-butyl ether and 1-octanol has been studied and compared with conventional EN590 Diesel fuel. For this purpose, OH"∗ chemiluminescence and shadowgraphy measurements in a high pressure chamber as well as 1D simulations with a spray model have been carried out at different operating conditions representative of the NEDC driving cycle. Finally, measured soot emissions in the single-cylinder engine were presented and discussed. Results from the high pressure chamber presented very good agreement in terms of liquid length and vapor penetration with simulation results. Thus, some analytical expressions related to macroscopic spray characteristics have been proposed and validated experimentally for all four fuels. Finally, the single-cylinder engine results confirmed the relevant role of soot formation on final emissions for 1-octanol and 2-MTHF. In addition, DNBE showed greater soot oxidation potential than diesel and other TMFB candidates.

  4. Effect of a tailor-made continuous medical education program for primary care physicians on self-perception of physicians' roles and quality of care.

    Science.gov (United States)

    Twig, Gilad; Lahad, Amnon; Kochba, Ilan; Ezra, Vered; Mandel, Dror; Shina, Avi; Kreiss, Yitshak; Zimlichman, Eyal

    2010-09-01

    A survey conducted among Israel Defense Force primary care physicians in 2001 revealed that they consider patients' needs more than they do organizational needs and that the education PCPs currently receive is inadequate. In 2003 the medical corps initiated a multi-format continuous medical education program aimed at improving skills in primary care medicine. To measure and analyze the effect of the tailor-made CME program on PCPs' self-perception 3 years after its implementation and correlate it to clinical performance. In 2006 a questionnaire was delivered to a representative sample of PCPs in the IDF. The questionnaire included items on demographic and professional background, statements on self-perception issues, and ranking of roles. We compared the follow-up survey (2006) to the results of the original study (2001) and correlated the survey results with clinical performance as measured through objective indicators. In the 2006 follow-up survey PCPs scored higher on questions dealing with their perception of themselves as case managers (3.8 compared to 4.0 on the 2001 survey on a 5 point scale, P = 0.046), perceived quality of care and education (3.5 vs. 3.8, P = 0.06), and on questions dealing with organizational commitment (3.5 vs. 3.8, P = 0.01). PCPs received higher scores on clinical indicators in the later study (odds ratio 2.05, P < 0.001). PCPs in the IDF perceived themselves more as case managers as compared to the 2001 survey. A tailor-made CME program may have contributed to the improvement in skills and quality of care.

  5. Tailor-made starch-based conjugates containing well-defined poly(vinyl acetate and its derivative poly(vinyl alcohol

    Directory of Open Access Journals (Sweden)

    2011-06-01

    Full Text Available Reversible addition-fragmentation chain transfer (RAFT polymerization was adopted to synthesize starch-based conjugates that possessed controllable architecture and properties. Starch-based xanthate agent was prepared and applied as chain transfer agent to conduct the living/controlled polymerization (LCP of vinyl acetate, which generated tailor-made conjugates of starch and well-defined poly(vinyl acetate (SVAc. The relevant derivatives, conjugates of starch and chain length-controlled poly(vinyl alcohol (SVA, were obtained subsequently. Various characterizations such as Fourier transform infrared spectra (FTIR, ultraviolet-visible spectroscopy (UV, proton nuclear magnetic resonance (1H NMR, gel permeation chromatography (GPC, X-ray diffraction (XRD, Thermogravimetric analysis (TGA, and dynamic mechanical thermal analysis (DMTA were performed to examine the structure of intermediates and the starch-based conjugates. Static contact angle measurements revealed that the hydrophilic character of starch-based conjugates was tunable. Well-defined SVAc was amphiphilic and it was able to self-assemble into size controllable micelles, which was verified by contact angles, transmission electron microscopy (TEM and dynamic light scattering (DLS tests. SVA exhibited much higher capability to form physically cross-linked hydrogel than starch did. Both the characteristic of SVAc and SVA were chain length-dependent.

  6. Tailor-made nano-structured materials for perpendicular recording media and head-precise control of direct/indirect exchange coupling

    International Nuclear Information System (INIS)

    Takahashi, Migaku; Tsunoda, Masakiyo; Saito, Shin

    2009-01-01

    Tailor-made nano-structured spin materials obtained by precisely controlled nano-scale fabrication technologies for use in ultra-high density hard disk drives (HDDs), as well as an understanding of their nanomagnetics, are essential from the view point of materials, processes, and physics. Artificial control of the exchange coupling among ferromagnetic layers through the RKKY interaction (indirect) and direct exchange coupling represented as the exchange bias at the ferromagnetic (FM)/antiferromagnetic (AFM) interface are of great interest and have received significant attention to induce new modulated spin structures in conventional simple FM materials. In particular, soft magnetic under layer (SUL) with strong synthetic antiferromagnetic (SAF) coupling between two adjacent soft magnetic layers, exchange coupled stacked media introducing exchange coupling between FM layers and giant exchange anisotropy at the FM/AFM interface have attracted significant attention from the view point of applications. Within the framework of the present paper, we discuss future technical trends for SUL, granular media and the spin-valve head from the viewpoint of direct and/or indirect exchange coupling based on our recent results

  7. Evaluation in participatory design

    DEFF Research Database (Denmark)

    Bossen, Claus; Dindler, Christian; Iversen, Ole Sejer

    2016-01-01

    his paper focuses on evaluation in Participatory Design (PD), and especially upon how the central aims of mutual learning, empowerment, democracy and workplace quality have been assessed. We surveyed all Participatory Design Conference papers (1990-2014) and papers from special journal issues on PD...

  8. Improving the physical health of people with severe mental illness : the need for tailor made care and uniform evaluation of interventions

    NARCIS (Netherlands)

    van Hasselt, Fenna Maria

    2013-01-01

    De levensverwachting van patiënten met een ernstige psychiatrische aandoening (EPA) is gemiddeld 13 tot 30 jaar korter dan die van de algemene bevolking. Dit komt voornamelijk door een vergroot risico op lichamelijke ziekten, zoals hart- en vaatziekten en suikerziekte. Uit onze studie blijkt dat de

  9. Individualized Tailor-Made Dietetic Intervention Program at Schools Enhances Eating Behaviors and Dietary Habits in Obese Hispanic Children of Low Socioeconomic Status

    Science.gov (United States)

    Moreno-Sànchez, Diana; Gutierrez, Norma G.; Lamadrid-Zertuche, Ana C.; Hernandez-Torre, Martin M.

    2014-01-01

    Hispanic children and those from low-socioeconomic status are predisposed to unhealthy eating habits and obesity. Aim. to implement an individualized, face-to-face, parent supported, and school-partnership dietetic intervention to promote healthy eating habits and decrease body mass index. Prospective school year dietetic intervention of 101 obese, Hispanic, low-socioeconomic school-age children representative of Monterrey, Mexico, consisted of anthropometrics, dietetic assessment, energy-restriction tailor-made daily menus, and parental education every three weeks. Student's t-test was used for means comparison. A significant decrease was found in body mass index percentile (96.43 ± 3.32 to 93.42 ± 8.12/P = 0.00) and energy intake/day of −755.7 kcal/day (P = 0.00). Among other energy dense foods with significant decline in servings/day and servings/week were processed meats (3.13 ± 1.43 to 2.19 ± 1.04/P = 0.00 and 5.60 ± 1.75 to 4.37 ± 2.10/P = 0.00, resp.), saturated fat (1.47 ± 1.08 to 0.78 ± 0.79/P = 0.00 and 2.19 ± 2.18 to 1.1 ± 1.36/P = 0.00), sweetened beverages (2.79 ± 1.99 to 1.42 ± 1.21 and 6.21 ± 1.72 to 3.89 ± 2.80/P = 0.00), and desserts and refined-grain bakery (1.99 ± 1.54 to 1.32 ± 1.59 and 2.85 ± 2.54 to 1.57 ± 2.20/P = 0.00). There was a significant increase in servings/day and servings/week of water (2.98 ± 2.02 to 4.91 ± 2.37 and 6.62 ± 2.03 to 6.87 ± 0.91/P = 0.00, resp.) and nutrient dense foods such as fruits (1.31 ± 0.89 to 1.66 ± 0.96 and 3.34 ± 2.24 to 4.28 ± 2.43/P = 0.00) and fish and poultry (3.76 ± 2.15 to 4.54 ± 2.25/P = 0.00). This intervention created healthy eating habits and decreased body mass index in a high risk population. Trial registration number: NCT01925976. PMID:24592170

  10. Individualized Tailor-Made Dietetic Intervention Program at Schools Enhances Eating Behaviors and Dietary Habits in Obese Hispanic Children of Low Socioeconomic Status

    Directory of Open Access Journals (Sweden)

    Leticia Elizondo-Montemayor

    2014-01-01

    Full Text Available Hispanic children and those from low-socioeconomic status are predisposed to unhealthy eating habits and obesity. Aim. to implement an individualized, face-to-face, parent supported, and school-partnership dietetic intervention to promote healthy eating habits and decrease body mass index. Prospective school year dietetic intervention of 101 obese, Hispanic, low-socioeconomic school-age children representative of Monterrey, Mexico, consisted of anthropometrics, dietetic assessment, energy-restriction tailor-made daily menus, and parental education every three weeks. Student’s t-test was used for means comparison. A significant decrease was found in body mass index percentile (96.43±3.32 to 93.42±8.12/P=0.00 and energy intake/day of −755.7 kcal/day (P=0.00. Among other energy dense foods with significant decline in servings/day and servings/week were processed meats (3.13 ± 1.43 to 2.19 ± 1.04/P=0.00 and 5.60 ± 1.75 to 4.37 ± 2.10/P=0.00, resp., saturated fat (1.47 ± 1.08 to 0.78 ± 0.79/P=0.00 and 2.19±2.18 to 1.1±1.36/P=0.00, sweetened beverages (2.79±1.99 to 1.42±1.21 and 6.21±1.72 to 3.89±2.80/P=0.00, and desserts and refined-grain bakery (1.99±1.54 to 1.32±1.59 and 2.85 ± 2.54 to 1.57 ± 2.20/P=0.00. There was a significant increase in servings/day and servings/week of water (2.98 ± 2.02 to 4.91 ± 2.37 and 6.62 ± 2.03 to 6.87 ± 0.91/P=0.00, resp. and nutrient dense foods such as fruits (1.31 ± 0.89 to 1.66 ± 0.96 and 3.34 ± 2.24 to 4.28 ± 2.43/P=0.00 and fish and poultry (3.76 ± 2.15 to 4.54 ± 2.25/P=0.00. This intervention created healthy eating habits and decreased body mass index in a high risk population. Trial registration number: NCT01925976.

  11. Novel approaches mediated by tailor-made green solvents for the extraction of phenolic compounds from agro-food industrial by-products.

    Science.gov (United States)

    Fernández, María de Los Ángeles; Espino, Magdalena; Gomez, Federico J V; Silva, María Fernanda

    2018-01-15

    An environmentally friendly method for the phenolic compound extraction from agro-food industrial by-products was developed in order to contribute with their sustainable valorization. A Natural Deep Eutectic Solvent was chemometrically-designed for the first time and compared with traditional solvents in terms of analyte stabilization. The combination of lactic acid, glucose and 15% water (LGH-15) was selected as optimal. A high-efficiency ultrasound-assisted extraction mediated by LGH-15 prior to HPLC-DAD allows the determination of 14 phenols in onion, olive, tomato and pear industrial by-products. NADES synthesis as well as the extraction procedures were optimized by Response Surface Methodology. Thus, phenolic determination in these complex samples was achieved by a simple, non-expensive, eco-friendly and robust system. The application to different matrices demonstrated the versatility of the proposed method. NADES opens interesting perspectives for their potential use as vehicles of bioactive compounds as food additives or pharmaceuticals. Copyright © 2017 Elsevier Ltd. All rights reserved.

  12. The impact of Tailor-Made skills based training programmes on the performance of municipalities: The case of the city of Tshwane

    Directory of Open Access Journals (Sweden)

    Solly Pooe

    2016-10-01

    Full Text Available Various South African municipalities are under close scrutiny due to widespread protests over poor quality of municipal services. Prior studies that examined situations in municipalities recommend training and development as the most apposite strategic tool for raising municipal performance. This study aimed to determine whether there is a statistically significant association between the provision of adequate training and development programmes and satisfactory performance at municipal level. A combination of quantitative and qualitative methods of data collection and analyses were used in the study in which data was collected from n=131 respondents (119 questionnaires + 12 in-depth interviews. Purposive sampling was used for selecting eligible respondents. The results showed that 49% of respondents have had past training opportunities. The percentage of employees with satisfactory performance was equal to 52%. The study found a significant association between the provision of training and development programmes and satisfactory performance among municipal employees. At the 5% level of significance, the results show that inadequate performance was significantly associated with lack of training opportunities, low level of formal education, and lack of job satisfaction, in a decreasing order of strength. A model has been proposed for ensuring adequate performance by municipal employees, and for monitoring and evaluating progress on a quarterly basis

  13. Tailor-made surfactants for optimized chemical EOR. Meeting oil reservoir conditions by applied knowledge of structure-performance relationship in extended surfactants

    Energy Technology Data Exchange (ETDEWEB)

    Trahan, G.; Sorensen, W. [Sasol North America Inc., Westlake, LA (United States); Jakobs-Sauter, B. [Sasol Germany GmbH (Germany)

    2013-08-01

    Formulating the surfactant package for chemical EOR is a time consuming and expensive process - the formulation needs to fit the specific reservoir conditions (like oil type, temperature, salinity, etc.) to give optimum performance and the number of formulation variables is virtually endless. This paper studies the impact of surfactant structure on EOR formulation ability and performance and how to adjust the structure of the surfactant molecule to meet a specific reservoir's needs. Data from salinity phase boundary studies of alcohol propoxy sulfates illustrate how changes in alcohol structure as well as in propylene oxide level can shift optimum salinity and temperature to the desired range in a given model oil. From these data the impact of individual structural units was evaluated. Application of the HLD model (Hydrophilic-Lipophilic Deviation) shows how to extrapolate from the known data set to actual reservoir conditions. This is illustrated by studies on crude oil samples. Additional tests study how effective the selected surfactants perform. The HLD concept proves to be a valuable tool to select and tailor surfactants to individual reservoir needs, thus simplifying the surfactant screening process for EOR formulations by pre-selection of suitable structures and ultimately reducing cost and effort on the way to the most effective chemical EOR package. (orig.)

  14. Evaluating aesthetics in design

    DEFF Research Database (Denmark)

    Folkmann, Mads Nygaard

    2010-01-01

    : an aesthetics of sensual relation and an aesthetics of communicative self-reflection. Following these concepts the article raises questions of dealing with design as a structure of sensual appearance, and of design as an act of communication that can contain an aesthetic coding in letting an idea or content...

  15. Tailor-Made Live Kidney Donation

    NARCIS (Netherlands)

    K.W.J. Klop (Karel)

    2014-01-01

    markdownabstract__Abstract__ This thesis describes several aspects of live kidney donation, such as surgical techniques, cost-effectivity, cosmetics en quality of life. Kidney transplantation offer several benefits when compared to dialysis. These benefits include better recipient and graft

  16. Pulmonary artery reconstruction with a tailor-made bovine pericardial conduit following sleeve resection of a long segmental pulmonary artery for the treatment of lung cancer: technical details of the dog-ear method for adjusting diameter during vascular anastomosis.

    Science.gov (United States)

    Shimizu, Kimihiro; Nagashima, Toshiteru; Ohtaki, Yoichi; Takahashi, Toru; Mogi, Akira; Kuwano, Hiroyuki

    2017-05-01

    Sleeve resection of the pulmonary artery (PA) is always required for lung-sparing operations in which half or more of the vessel circumference is infiltrated by the primary tumor or metastatic hilar nodes. Following sleeve resection, conduit reconstruction may be indicated if there is excessive distance between the two vascular stumps, because there is a high degree of tension when repaired by direct anastomosis. We herein present a case of PA reconstruction using a tailor-made bovine pericardial conduit after sleeve resection of PA during lung cancer surgery. The length of resection was longer than 3 cm, and the difference in diameter between the conduit and peripheral PA stump was larger than 0.5 cm. We describe the surgical and oncological merits of a bovine pericardial conduit, and provide details of our reconstruction technique, focusing on adjustment of diameter between the conduit and peripheral PA (dog-ear method).

  17. Reduction of CO{sub 2} emission by means of innovative, tailor-made gear oils. What gear oils may contribute to fuel savings; Reduktion der CO{sub 2}-Emission durch innovative, massgeschneiderte Getriebeoele. Was Getriebeoele zur Kraftstoffeinsparung beitragen koennen

    Energy Technology Data Exchange (ETDEWEB)

    Kraneburg, Peter; Vomhof, Ulrich [Castrol, Hamburg (Germany)

    2009-07-01

    To achieve the ACEA self commitment the automotive OEMs have worked hard to make their cars more energy efficient. Various steps on aerodynamics, engines and transmissions led to significant steps to reduce the CO{sub 2} emissions. Further steps will become smaller and more expensive but the EU regulation will enforce them. In this article we will show what benefit a fuel efficient lubricant for transmissions can contribute to this targets. The universal API GL4 and API GL5 oils belong to the past. Today the challenge is to tailor-made transmission oil for a specific transmission to release the maximum potential of fuel economy. A reduced viscosity can allow up to 2% lower fuel consumption. New transmission concepts like Dual Clutch Tranmissions can only deliver their benefits with specially designed fluids. Applying a ''Co-engineering'' concept during the transmission design phase even bigger potentials can be realised. This will lead to further reduction of viscosity, synthetic oils, spray lubrication and heat management. The lubricant is an important construction element for modern transmissions. (orig.)

  18. Novel method for the rapid and specific extraction of multiple β2 -agonist residues in food by tailor-made Monolith-MIPs extraction disks and detection by gas chromatography with mass spectrometry.

    Science.gov (United States)

    Liu, Haibo; Gan, Ning; Chen, Yinji; Ding, Qingqing; Huang, Jie; Lin, Saichai; Cao, Yuting; Li, Tianhua

    2016-09-01

    A quick and specific pretreatment method based on a series of extraction clean-up disks, consisting of molecularly imprinted polymer monoliths and C18 adsorbent, was developed for the specific enrichment of salbutamol and clenbuterol residues in food. The molecularly imprinted monolithic polymer disk was synthesized using salbutamol as a template through a one-step synthesis process. It can simultaneously and specifically recognize salbutamol and clenbuterol. The monolithic polymer disk and series of C18 disks were assembled with a syringe to form a set of tailor-made devices for the extraction of target molecules. In a single run, salbutamol and clenbuterol can be specifically extracted, cleaned, and eluted by methanol/acetic acid/H2 O. The target molecules, after a silylation derivatization reaction were detected by gas chromatography-mass spectrometry. The parameters including solvent desorption, sample pH, and the cycles of reloading were investigated and discussed. Under the optimized extraction and clean-up conditions, the limits of detection and quantitation were determined as 0.018-0.022 and 0.042-0.049 ng/g for salbutamol and clenbuterol, respectively. The assay described was convenient, rapid, and specific; thereby potentially efficient in the high-throughput analysis of β2 -agonists residues in real food samples. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  19. Modular system design and evaluation

    CERN Document Server

    Levin, Mark Sh

    2015-01-01

    This book examines seven key combinatorial engineering frameworks (composite schemes consisting of algorithms and/or interactive procedures) for hierarchical modular (composite) systems. These frameworks are based on combinatorial optimization problems (e.g., knapsack problem, multiple choice problem, assignment problem, morphological clique problem), with the author’s version of morphological design approach – Hierarchical Morphological Multicritieria Design (HMMD) – providing a conceptual lens with which to elucidate the examples discussed. This approach is based on ordinal estimates of design alternatives for systems parts/components, however, the book also puts forward an original version of HMMD that is based on new interval multiset estimates for the design alternatives with special attention paid to the aggregation of modular solutions (system versions). The second part of ‘Modular System Design and Evaluation’ provides ten information technology case studies that enriches understanding of th...

  20. Evaluating an artifact in design science research

    CSIR Research Space (South Africa)

    Herselman, M

    2015-09-01

    Full Text Available In this paper, we describe the iterative evaluation of an artifact developed through the application of Design Science Research (DSR) methodology in a resource constrained environment. In the DSR process the aspect of evaluation is often done...

  1. Design for Motivation: Evaluation of a Design Tool

    Directory of Open Access Journals (Sweden)

    Dimitra Chasanidou

    2018-02-01

    Full Text Available Design for motivation constitutes a design practice that focuses on the activation of human motives to perform an action. There is an increasing need to design motivational and engaging mechanisms for voluntary systems, such as innovation platforms, where user participation is a key target. When designing for motivation, a challenge of the early design phases is the selection of appropriate design tool and strategy. The current work presents a design tool, namely DEMO (DEsign for MOtivation, and evaluates its design process. The tool provides multidisciplinary teams with a user-centred, structured method to ideate and ultimately develop a consistent design plan to engage the users of innovation platforms. The evaluation study analysed the tool’s contribution to the design of motivational innovation platforms, utilising three data collection methods: a protocol analysis, interviews and questionnaires. The results discuss the experiences of 32 users with the development of motivation concepts, the group and the user activities, as well as their creativity aspects. Structured processes and the use of artefacts were found to be productive practices in the early design phases. The results also highlight the importance of multidisciplinary and user-centred teams that can enhance collaboration and communication during the design processes.

  2. Loudspeaker Design and Performance Evaluation

    Science.gov (United States)

    Mäkivirta, Aki Vihtori

    A loudspeaker comprises transducers converting an electrical driving signal into sound pressure, an enclosure working as a holder for transducers, front baffle and box to contain and eliminate the rear-radiating audio signal, and electronic components. Modeling of transducers as well as enclosures is treated in Chap. 32 of this handbook. The purpose of the present chapter is to shed light on the design choices and options for the electronic circuits conditioning the electrical signal fed into loudspeaker transducers in order to optimize the acoustic performance of the loudspeaker.

  3. Stereoscopic game design and evaluation

    Science.gov (United States)

    Rivett, Joe; Holliman, Nicolas

    2013-03-01

    We report on a new game design where the goal is to make the stereoscopic depth cue sufficiently critical to success that game play should become impossible without using a stereoscopic 3D (S3D) display and, at the same time, we investigate whether S3D game play is affected by screen size. Before we detail our new game design we review previously unreported results from our stereoscopic game research over the last ten years at the Durham Visualisation Laboratory. This demonstrates that game players can achieve significantly higher scores using S3D displays when depth judgements are an integral part of the game. Method: We design a game where almost all depth cues, apart from the binocular cue, are removed. The aim of the game is to steer a spaceship through a series of oncoming hoops where the viewpoint of the game player is from above, with the hoops moving right to left across the screen towards the spaceship, to play the game it is essential to make decisive depth judgments to steer the spaceship through each oncoming hoop. To confound these judgements we design altered depth cues, for example perspective is reduced as a cue by varying the hoop's depth, radius and cross-sectional size. Results: Players were screened for stereoscopic vision, given a short practice session, and then played the game in both 2D and S3D modes on a seventeen inch desktop display, on average participants achieved a more than three times higher score in S3D than they achieved in 2D. The same experiment was repeated using a four metre S3D projection screen and similar results were found. Conclusions: Our conclusion is that games that use the binocular depth cue in decisive game judgements can benefit significantly from using an S3D display. Based on both our current and previous results we additionally conclude that display size, from cell-phone, to desktop, to projection display does not adversely affect player performance.

  4. HTGR fuel particle crusher design evaluation

    International Nuclear Information System (INIS)

    Johanson, N.W.

    1978-10-01

    This report describes an evaluation of the design of the existing engineering-scale fuel particle crushing system for the HTGR reprocessing cold pilot plant at General Atomic Company (GA). The purpose of this evaluation is to assess the suitability of the existing design as a prototype of the HTGR Recycle Reference Facility (HRRF) particle crushing system and to recommend alternatives where the existing design is thought to be unsuitable as a prototype. This evaluation has led to recommendations for an upgraded design incorporating improvements in bearing and seal arrangement, housing construction, and control of roll gap thermal expansion. 23 figures, 6 tables

  5. Design evaluation of emergency core cooling systems using Axiomatic Design

    Energy Technology Data Exchange (ETDEWEB)

    Heo, Gyunyoung [Massachusetts Institute of Technology, Department of Mechanical Engineering, 77 Massachusetts Avenue, Cambridge, MA 02139 (United States)]. E-mail: gheo@mit.edu; Lee, Song Kyu [Korea Advanced Institute of Science and Technology, Department of Nuclear and Quantum Engineering, 373-1 Guseong-dong, Yuseong-gu, Daejeon (Korea, Republic of)

    2007-01-15

    In designing nuclear power plants (NPPs), the evaluation of safety is one of the important issues. As a measure for evaluating safety, this paper proposes a methodology to examine the design process of emergency core cooling systems (ECCSs) in NPPs using Axiomatic Design (AD). This is particularly important for identifying vulnerabilities and creating solutions. Korean Advanced Power Reactor 1400 MWe (APR1400) adopted the ECCS, which was improved to meet the stronger safety regulations than that of the current Optimized Power Reactor 1000 MWe (OPR1000). To improve the performance and safety of the ECCS, the various design strategies such as independency or redundancy were implemented, and their effectiveness was confirmed by calculating core damage frequency. We suggest an alternative viewpoint of evaluating the deployment of design strategies in terms of AD methodology. AD suggests two design principles and the visualization tools for organizing design process. The important benefit of AD is that it is capable of providing suitable priorities for deploying design strategies. The reverse engineering driven by AD has been able to show that the design process of the ECCS of APR1400 was improved in comparison to that of OPR1000 from the viewpoint of the coordination of design strategies.

  6. SGHWR safety design and evaluation

    International Nuclear Information System (INIS)

    Smith, D.R.; Merrett, D.J.; Ward, D.A.

    1977-01-01

    The paper discusses the characteristic features of the S.G.H.W.R. and identifies the single channel concept as of considerable importance. The unique feature of the design is the provision of individual spray cooling E.C.C.S. to each channel. This spray cooling occupies a prominent position in the main line safety arguments. The reliance on this form of spray cooling leads to provision of a comprehensive E.C.C.S. system of high reliability. Duplicate systems with diverse power and water sources cover the complete pressure range to give very high confidence that spray cooling is available in all major L.O.C.A.s. On the other hand hydraulic analysis of the blowdown phase demonstrates that significant convective flow is available as an alternative/supplementary cooling regime for most faults. The reactor shutdown mechanisms have also been duplicated and will be designed to high reliabilities to give surety of reactor trip in all credible faults. The comparative performance of the two systems is considered. Extent of diversity and redundancy in trip parameters is also discussed. A feature of channel concept is that the pipe sizes can be made relatively small thus restricting rates of blowdown, and the paper discusses effects of this upon long term cooling and flooding arguments. The quantities of pipework in the primary circuit introduce considerations of integrity and the paper goes on to list the measures introduced to improve segregation and protection of individual sections of the plant so that the extent of possible L.O.C.A.s is minimised. The achievement of high standards of reliability by use of in-service inspection is covered, with particular reference to the steam drums. The impact of these inspection requirements upon the very low man-rem exposures required by U.K. utilities is also included. Finally, it is noted that the provision of containment in common with other L.W.R. practice also provides a valuable engineered safety feature. The principles of

  7. Software for Evaluation of Conceptual Design

    DEFF Research Database (Denmark)

    Hartvig, Susanne C

    1998-01-01

    by the prototype, it addresses the requirements that the methods imply, and it explains the actual implementation of the prototype. Finally it discusses what have been learned from developing and testing the prototype. In this paper it is suggested, that a software tool which supports evaluation of design can...... be developed with a limited effort, and that such tools could support a structured evaluation process as opposed to no evaluation. Compared to manual evaluation, the introduced software based evaluation tool offers automation of tasks, such as performing assessments, when they are based on prior evaluations...

  8. Scaling Research Results: Design and Evaluation | IDRC ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Design and evaluation The project will provide helpful guidance to IDRC management and ... scaling and programming for scalable research Offer the monograph in multiple forms, ... Asian outlook: New growth dependent on new productivity.

  9. New tools for evaluating LQAS survey designs

    OpenAIRE

    Hund, Lauren

    2014-01-01

    Lot Quality Assurance Sampling (LQAS) surveys have become increasingly popular in global health care applications. Incorporating Bayesian ideas into LQAS survey design, such as using reasonable prior beliefs about the distribution of an indicator, can improve the selection of design parameters and decision rules. In this paper, a joint frequentist and Bayesian framework is proposed for evaluating LQAS classification accuracy and informing survey design parameters. Simple software tools are pr...

  10. Designing evaluation of learning in outline courses

    Directory of Open Access Journals (Sweden)

    Estévez, Orosmán V.

    2010-07-01

    Full Text Available This paper is intended to characterize the evaluation process of online courses from the perspectives of several scholars who are currently conducting research on the topic. The importance of an integral diagnosis and the interconnections between diagnosis, learning activities design and evaluation are outlined. The study leads the authors to the conclusion that evaluation in online courses in Cuba demands a thorough scientific research so as to go deeper into its characterizing features.

  11. Designer's requirements for evaluation of sustainability

    DEFF Research Database (Denmark)

    Bey, Niki; Lenau, Torben Anker

    1998-01-01

    Today, sustainability of products is often evaluated on the basis of assessments of their environmental performance. Established means for this purpose are formal Life Cycle Assessment (LCA) methods. Designers have an essential influence on product design and are therefore one target group for life...... cycle-based evaluation methods. However, the application of LCA in the design process, when for example different materials and manufacturing processes have to be selected, is difficult. This is, among other things, because only a few designers have a deeper background in this area and even simplified...... LCAs involve calculations with a relatively high accuracy. Most LCA methods do therefore not qualify as hands-on tool for utilisation by typical designers.In this context, the authors raise the question, whether a largely simplified LCA-method which is exclusively based on energy considerations can...

  12. Physical protection system design and evaluation

    International Nuclear Information System (INIS)

    Williams, J.D.

    1997-01-01

    The design of an effective physical protection system includes the determination of physical protection system objectives, initial design of a physical protection system, design evaluation, and probably a redesign or refinement. To develop the objectives, the designer must begin by gathering information about facility operation and conditions, such as a comprehensive description of the facility, operating conditions, and the physical protection requirements. The designer then needs to define the threat. This involves considering factors about potential adversaries: class of adversary, adversary's capabilities, and range of adversary's tactics. Next, the designer should identify targets. Determination of whether or not the materials being protected are attractive targets is based mainly on the ease or difficulty of acquisition and desirability of the material. The designer now knows the objectives of the physical protection system, that is, open-quotes what to protect against whom.close quotes The next step is to design the system by determining how best to combine such elements as fences, vaults, sensors and assessment devices, entry control elements, procedures, communication devices, and protective forces personnel to meet the objectives of the system. Once a physical protection system is designed, it must be analyzed and evaluated to ensure it meets the physical protection objectives. Evaluation must allow for features working together to ensure protection rather than regarding each feature separately. Due to the complexity of the protection systems, an evaluation usually requires modeling techniques. If any vulnerabilities are found, the initial system must be redesigned to correct the vulnerabilities and a reevaluation conducted. This paper reviews the physical protection system design and methodology mentioned above. Examples of the steps required and a brief introduction to some of the technologies used in modem physical protections system are given

  13. Physical protection system design and evaluation

    International Nuclear Information System (INIS)

    Williams, J.D.

    1997-11-01

    The design of an effective physical protection system (PPS) includes the determination of the PPS objectives, the initial design of a PPS, the evaluation of the design, and probably, the redesign or refinement of the system. To develop the objectives, the designer must begin by gathering information about facility operation and conditions, such as a comprehensive description of the facility, operating conditions, and the physical protection requirements. The designer then needs to define the threat. This involves considering factors about potential adversaries: class of adversary, adversary's capabilities, and range of adversary's tactics. Next, the designer should identify targets. Determination of whether or not the materials being protected are attractive targets is based mainly on the ease or difficulty of acquisition and desirability of the material. The designer now knows the objectives of the PPS, that is, ''what to protect against whom.'' The next step is to design the system by determining how best to combine such elements as fences, vaults, sensors and assessment devices, entry control devices, communication devices, procedures, and protective force personnel to meet the objectives of the system. Once a PPS is designed, it must be analyzed and evaluated to ensure it meets the PPS objectives. Evaluation must allow for features working together to ensure protection rather than regarding each feature separately. Due to the complexity of the protection systems, an evaluation usually requires modeling techniques. If any vulnerabilities are found, the initial system must be redesigned to correct the vulnerabilities and a reevaluation conducted. After the system is installed, the threat and system parameters may change with time. If they do, the analysis must be performed periodically to ensure the system objectives are still being met

  14. Gasifier feed: Tailor-made from Illinois coals

    Energy Technology Data Exchange (ETDEWEB)

    Ehrlinger, H.P. III.

    1991-01-01

    The purpose of this research is to develop a coal slurry from waste streams using Illinois coal that is ideally suited for a gasification feed. The principle items to be studied are (1) methods of concentrating pyrite and decreasing other ash forming minerals into a high grade gasification feed using froth flotation and gravity separation techniques; (2) chemical and particle size analyses of coal slurries; (3) determination of how that slurry can be densified and to what degree of densification is optimum from the pumpability and combustibility analyses; and (4) reactivity studies.

  15. Aerogels in Chemical Engineering: Strategies Toward Tailor-Made Aerogels.

    Science.gov (United States)

    Smirnova, Irina; Gurikov, Pavel

    2017-06-07

    The present review deals with recent advances in the rapidly growing field of aerogel research and technology. The major focus of the review lies in approaches that allow tailoring of aerogel properties to meet application-driven requirements. The decisive properties of aerogels are discussed with regard to existing and potential application areas. Various tailoring strategies, such as modulation of the pore structure, coating, surface modification, and post-treatment, are illustrated by results of the last decade. In view of commercialization of aerogel-based products, a panorama of current industrial aerogel suppliers is given, along with a discussion of possible alternative sources for raw materials and precursors. Finally, growing points and perspectives of the aerogel field are summarized.

  16. Tailor-Made Fluorescent Trilobolide To Study Its Biological Relevance

    Czech Academy of Sciences Publication Activity Database

    Jurášek, M.; Rimpelová, S.; Kmoníčková, Eva; Drašar, P.; Ruml, T.

    2014-01-01

    Roč. 57, č. 19 (2014), s. 7947-7954 ISSN 0022-2623 Grant - others:GA ČR(CZ) GA14-28334S; GA MŠMT(CZ) 20/2014 Program:GA Institutional support: RVO:68378041 Keywords : trilobolide * nitric oxide * endoplasmic reticulum Subject RIV: FR - Pharmacology ; Medidal Chemistry Impact factor: 5.447, year: 2014

  17. Tailor-made fructan synthesis in plants: A review

    NARCIS (Netherlands)

    Arkel, van J.; Sévenier, R.; Hakkert, J.C.; Bouwmeester, H.J.; Koops, A.J.; Meer, van der I.M.

    2013-01-01

    Fructan, a fructose polymer, is produced by many bacteria and plants. Fructan is used as carbohydrate reserve, and in bacteria also as protective outside layer. Chicory is a commercial fructan producing crop. The disadvantage of this crop is its fructan breakdown before harvest. Studies using

  18. Ceramic Nanocomposites from Tailor-Made Preceramic Polymers

    Directory of Open Access Journals (Sweden)

    Gabriela Mera

    2015-04-01

    Full Text Available The present Review addresses current developments related to polymer-derived ceramic nanocomposites (PDC-NCs. Different classes of preceramic polymers are briefly introduced and their conversion into ceramic materials with adjustable phase compositions and microstructures is presented. Emphasis is set on discussing the intimate relationship between the chemistry and structural architecture of the precursor and the structural features and properties of the resulting ceramic nanocomposites. Various structural and functional properties of silicon-containing ceramic nanocomposites as well as different preparative strategies to achieve nano-scaled PDC-NC-based ordered structures are highlighted, based on selected ceramic nanocomposite systems. Furthermore, prospective applications of the PDC-NCs such as high-temperature stable materials for thermal protection systems, membranes for hot gas separation purposes, materials for heterogeneous catalysis, nano-confinement materials for hydrogen storage applications as well as anode materials for secondary ion batteries are introduced and discussed in detail.

  19. Ceramic Nanocomposites from Tailor-Made Preceramic Polymers.

    Science.gov (United States)

    Mera, Gabriela; Gallei, Markus; Bernard, Samuel; Ionescu, Emanuel

    2015-04-01

    The present Review addresses current developments related to polymer-derived ceramic nanocomposites (PDC-NCs). Different classes of preceramic polymers are briefly introduced and their conversion into ceramic materials with adjustable phase compositions and microstructures is presented. Emphasis is set on discussing the intimate relationship between the chemistry and structural architecture of the precursor and the structural features and properties of the resulting ceramic nanocomposites. Various structural and functional properties of silicon-containing ceramic nanocomposites as well as different preparative strategies to achieve nano-scaled PDC-NC-based ordered structures are highlighted, based on selected ceramic nanocomposite systems. Furthermore, prospective applications of the PDC-NCs such as high-temperature stable materials for thermal protection systems, membranes for hot gas separation purposes, materials for heterogeneous catalysis, nano-confinement materials for hydrogen storage applications as well as anode materials for secondary ion batteries are introduced and discussed in detail.

  20. Ceramic Nanocomposites from Tailor-Made Preceramic Polymers

    OpenAIRE

    Mera, Gabriela; Gallei, Markus; Bernard, Samuel; Ionescu, Emanuel

    2015-01-01

    The present Review addresses current developments related to polymer-derived ceramic nanocomposites (PDC-NCs). Different classes of preceramic polymers are briefly introduced and their conversion into ceramic materials with adjustable phase compositions and microstructures is presented. Emphasis is set on discussing the intimate relationship between the chemistry and structural architecture of the precursor and the structural features and properties of the resulting ceramic nanocomposites. Va...

  1. Tailor-made training for digital library software

    CERN Multimedia

    Joannah Caborn Wengler

    2012-01-01

    Six librarians and IT engineers from Senegal, Mali, Burkina Faso, Ivory Coast and Morocco are currently spending several weeks at CERN as a follow-up to the 5-day CERN-UNESCO Digital Libraries School held in Dakar, Senegal, last year. During their stay, they are honing their mastery of CERN’s Invenio digital library management platform in order to put it to a variety of uses once they return home.   From left to right: Essaid Ait Allal (Morocco), Guillaume Nikiema (Burkina Faso), Eric Guedegbe (Senegal), Fama Diagne Sene Ndiaye (Senegal), Abdrahamane Anne (Mali) and Jens VIGEN (CERN).  Cécile Coulibaly (Ivory Coast), who was also taking part in the training programme, is not in the picture. “We plan to use Invenio to build a portal for all African university dissertations to make them accessible to the global academic community. We need a system which can harvest data from various existing platforms, then convert the bibliographic records and make them...

  2. Desensitization to clopidogrel: a tailor-made protocol.

    Science.gov (United States)

    Barreira, P; Cadinha, S; Malheiro, D; Moreira da Silva, J P

    2014-01-01

    Clopidogrel is an antiplatelet drug widely used for treatment and prevention of a variety of cardiovascular diseases. We report a successful desensitization to clopidogrel in a 70-year-old Caucasian man with delayed hypersensitivity (HS) reaction. He developed lip, hand and foot swelling, erythematous papular non-pruritic lesions and arthralgias 2 weeks after starting treatment with clopidogrel 75 mg/d. A 3-hour desensitization protocol was started, achieving a cumulative dose of 154 mg without any reaction, and a daily dose of 75 mg was recommended. On the 4th day, the patient developed skin lesions similar to the previously described. He was treated with topical steroids and oral antihistamines, and the daily dose of clopidogrel was reduced to 20 mg. A new desensitization protocol was established, with a slow dose increment, according to the patient's response. It was only possible to achieve the dose of 75 mg/d after 2 months. Although well tolerated by most patients, HS reactions with clopidogrel may occur and desensitization is rising as a safe alternative in those patients. In delayed reactions with cutaneous lesions, a slower desensitization protocol may be necessary, as in this case.

  3. Ceramic Nanocomposites from Tailor-Made Preceramic Polymers

    Science.gov (United States)

    Mera, Gabriela; Gallei, Markus; Bernard, Samuel; Ionescu, Emanuel

    2015-01-01

    The present Review addresses current developments related to polymer-derived ceramic nanocomposites (PDC-NCs). Different classes of preceramic polymers are briefly introduced and their conversion into ceramic materials with adjustable phase compositions and microstructures is presented. Emphasis is set on discussing the intimate relationship between the chemistry and structural architecture of the precursor and the structural features and properties of the resulting ceramic nanocomposites. Various structural and functional properties of silicon-containing ceramic nanocomposites as well as different preparative strategies to achieve nano-scaled PDC-NC-based ordered structures are highlighted, based on selected ceramic nanocomposite systems. Furthermore, prospective applications of the PDC-NCs such as high-temperature stable materials for thermal protection systems, membranes for hot gas separation purposes, materials for heterogeneous catalysis, nano-confinement materials for hydrogen storage applications as well as anode materials for secondary ion batteries are introduced and discussed in detail. PMID:28347023

  4. Vaccine adjuvants: Tailor-made mast-cell granules

    Science.gov (United States)

    Gunzer, Matthias

    2012-03-01

    Mast cells induce protective immune responses through secretion of stimulatory granules. Microparticles modelled after mast-cell granules are now shown to replicate and enhance the functions of their natural counterparts and to direct the character of the resulting immunity.

  5. Evaluation of Frameworks for HSCT Design Optimization

    Science.gov (United States)

    Krishnan, Ramki

    1998-01-01

    This report is an evaluation of engineering frameworks that could be used to augment, supplement, or replace the existing FIDO 3.5 (Framework for Interdisciplinary Design and Optimization Version 3.5) framework. The report begins with the motivation for this effort, followed by a description of an "ideal" multidisciplinary design and optimization (MDO) framework. The discussion then turns to how each candidate framework stacks up against this ideal. This report ends with recommendations as to the "best" frameworks that should be down-selected for detailed review.

  6. Cockpit design and evaluation using interactive graphics

    Science.gov (United States)

    Evans, S. M.

    1975-01-01

    A general overview of the characteristics of an interactive graphics system which was developed to assist cockpit engineers design and evaluate work stations was presented. The manikin used in this COMputerized BIomechanical MAN-model (COMBIMAN) was described, as are provisions for generating work stations and assessing interactions between man and environment. The applications of the present system are explained, and critiques of COMBIMAN are presented. The limitations of the existing programs and the requirements of the designers necessitate future revisions and additions to the biomechanical and erogonomic properties of COMBIMAN. Some of these enhancements are discussed.

  7. Cooperation in reactor design evaluation and licensing

    International Nuclear Information System (INIS)

    Kaufer, B.; Wasylyk, A.

    2014-01-01

    In January 2007 the World Nuclear Association (WNA) established the Cooperation in Reactor Design Evaluation and Licensing (CORDEL) Working Group with the aim of stimulating a dialogue between the nuclear industry (including reactor vendors, operators and utilities) and nuclear regulators (national and international organisations) on the benefits and means of achieving a worldwide convergence of reactor safety standards for reactor designs. From the time of its inception to the present, CORDEL has evolved from a group of experts discussing how to achieve international standardisation in nuclear safety design to an established and recognised working group dedicated to analysing and forging common understandings in key areas as input to major decisions on nuclear energy policy. This paper will review the general directions and activities CORDEL plans to undertake during the next five-year period, including its general strategy, activities, priorities and interactions with its customers in order to meet its objectives. (author)

  8. Cooperation in reactor design evaluation and licensing

    Energy Technology Data Exchange (ETDEWEB)

    Kaufer, B.; Wasylyk, A. [World Nuclear Association, London (United Kingdom)

    2014-07-01

    In January 2007 the World Nuclear Association (WNA) established the Cooperation in Reactor Design Evaluation and Licensing (CORDEL) Working Group with the aim of stimulating a dialogue between the nuclear industry (including reactor vendors, operators and utilities) and nuclear regulators (national and international organisations) on the benefits and means of achieving a worldwide convergence of reactor safety standards for reactor designs. From the time of its inception to the present, CORDEL has evolved from a group of experts discussing how to achieve international standardisation in nuclear safety design to an established and recognised working group dedicated to analysing and forging common understandings in key areas as input to major decisions on nuclear energy policy. This paper will review the general directions and activities CORDEL plans to undertake during the next five-year period, including its general strategy, activities, priorities and interactions with its customers in order to meet its objectives. (author)

  9. [Design and evaluation of DAVIH VIH-2].

    Science.gov (United States)

    Martín Alfonso, Dayamí; Silva Cabrera, Eladio; Pérez Guevara, María T; Díaz Herrera, Dervel F; Romero Martínez, Kenia; Díaz Torres, Héctor M; Lubián Caballero, Ana L; Ruiz Gutiérrez, Nancy; Ortiz Losada, Eva

    2007-01-01

    The results of the design and evaluation of DAVIH VIH-2 diagnosing system, an indirect Elisa for screening of HIV-2 antibodies, which uses a HIV-2 glycoprotein gp36 synthetic peptide in its solid phase, were exposed. In the system evaluation using WHO reference panels, 100% sensitivity, 99,81% specificity, 99,81% efficacy and very good concordance level (kappa = 0.978) were attained. Serum samples of 959 individuals with undetermined or negative results to the HIV-1 antibodies confirmation (DAVIH blot) were evaluated by the DAVIH VIH-2 system. Twenty four samples were reactive, six of which had confirmed HIV-2 antibodies. These results allowed recommending the introduction of this diagnostic kit in the HIV infection diagnosing algorithm in Cuba.

  10. New tools for evaluating LQAS survey designs.

    Science.gov (United States)

    Hund, Lauren

    2014-02-15

    Lot Quality Assurance Sampling (LQAS) surveys have become increasingly popular in global health care applications. Incorporating Bayesian ideas into LQAS survey design, such as using reasonable prior beliefs about the distribution of an indicator, can improve the selection of design parameters and decision rules. In this paper, a joint frequentist and Bayesian framework is proposed for evaluating LQAS classification accuracy and informing survey design parameters. Simple software tools are provided for calculating the positive and negative predictive value of a design with respect to an underlying coverage distribution and the selected design parameters. These tools are illustrated using a data example from two consecutive LQAS surveys measuring Oral Rehydration Solution (ORS) preparation. Using the survey tools, the dependence of classification accuracy on benchmark selection and the width of the 'grey region' are clarified in the context of ORS preparation across seven supervision areas. Following the completion of an LQAS survey, estimation of the distribution of coverage across areas facilitates quantifying classification accuracy and can help guide intervention decisions.

  11. Design for Motivation: Evaluation of a Design Tool

    OpenAIRE

    Chasanidou, Dimitra

    2018-01-01

    Design for motivation constitutes a design practice that focuses on the activation of human motives to perform an action. There is an increasing need to design motivational and engaging mechanisms for voluntary systems, such as innovation platforms, where user participation is a key target. When designing for motivation, a challenge of the early design phases is the selection of appropriate design tool and strategy. The current work presents a design tool, namely DEMO (DEsign for MOtivation),...

  12. Evaluations of 1990 PRISM design revisions

    International Nuclear Information System (INIS)

    Van Tuyle, G.J.; Slovik, G.C.; Chan, B.C.; Aronson, A.L.; Kennett, R.J.

    1992-03-01

    Analyses of the 1990 version of the PRISM Advanced Liquid Metal Reactor (ALMR) design are presented and discussed. Most of the calculations were performed using BNL computer codes, particularly SSC and MINET. In many cases, independent BNL calculations were compared against analyses presented by General Electric when they submitted the PRISM design revisions for evaluation by the Nuclear Regulatory Commission (NRC). The current PRISM design utilizes the metallic fuel developed by Argonne National Laboratory (ANL) which facilitates the passive/''inherent'' shutdown mechanism that acts to shut down reactor power production whenever the system overheats. There are a few vulnerabilities in the passive shutdown, with the most worrisome being the positive feedback from sodium density decreases or sodium voiding. Various postulated unscrammed events were examined by GE and/or BNL, and much of the analysis discussed in this report is focused on this category of events. For the most part, the BNL evaluations confirm the information submitted by General Electric. The principal areas of concern are related to the performance of the ternary metal fuel, and may be resolved as ANL continues with its fuel development and testing program

  13. A SUMMARY COMPARISON OF DESIGN EVALUATION TECHNIQUES

    Energy Technology Data Exchange (ETDEWEB)

    Spielman, Zachary; Hill, Rachael

    2017-06-01

    The United States’ fleet of Nuclear Reactors is considering modernizing their control rooms and instrumentation as an effort to avoid component obsolescence, keep up with competing industries, and cater to a new work force among others. Multiple technologies have potential to improve the control room. In attempts to evaluate the available options researchers employ a variety of measures to ensure the best candidate is used in a modernizing effort. The NRC is in charge of ensuring any new design has been thoroughly vetted before approving a license. Laid out in NUREG-0711 “Human Factors Engineering Program Review Model” is the review criteria for design validation. As there are a variety of measures currently used to evaluate candidate technologies, this paper seeks to identify weaknesses in the common measures used to design and validate technology in control room modernization efforts. Identifying where measurements are not meeting the criteria will help the control room modernization research platform identify where measurement development needs to occur. This will help ensure that current performance measurements are producing as reliable results as possible to select the right technology to integrate into nuclear operating control rooms.

  14. Evaluating Stellarator Divertor Designs with EMC3

    Science.gov (United States)

    Bader, Aaron; Anderson, D. T.; Feng, Y.; Hegna, C. C.; Talmadge, J. N.

    2013-10-01

    In this paper various improvements of stellarator divertor design are explored. Next step stellarator devices require innovative divertor solutions to handle heat flux loads and impurity control. One avenue is to enhance magnetic flux expansion near strike points, somewhat akin to the X-Divertor concept in Tokamaks. The effect of judiciously placed external coils on flux deposition is calculated for configurations based on the HSX stellarator. In addition, we attempt to optimize divertor plate location to facilitate the external coil placement. Alternate areas of focus involve altering edge island size to elucidate the driving physics in the edge. The 3-D nature of stellarators complicates design and necessitates analysis of new divertor structures with appropriate simulation tools. We evaluate the various configurations with the coupled codes EMC3-EIRENE, allowing us to benchmark configurations based on target heat flux, impurity behavior, radiated power, and transitions to high recycling and detached regimes. Work supported by DOE-SC0006103.

  15. Structural evaluation in the design of electrorefiner

    International Nuclear Information System (INIS)

    Wu, T.S.; Blomquist, C.A.; Herceg, J.E.

    1995-01-01

    The electrorefiner (ER) is one piece of the process equipment for the Integral Fast Reactor (IFR) program. The ER's principal function is to perform the pyrochemical and electrochemical refining of spent and experimental fuel elements. Its principal components include a primary vessel, a heater assembly, a support-structure assembly, a cover assembly, four electrode assemblies, four elevator and rotator assemblies, and a cover-gas system. In addition, there are various miscellaneous tools and fixtures. The electrorefiner is to be installed within an existing enclosed cell. Design requirements dictate that all equipment within the cell should not be anchored. To assess the integrity of the electrorefiner during operational and seismic loads, extensive structural analyses have been performed. This paper presents some of the major structural evaluations for the electrorefiner and its auxiliary equipment. Results show that the design code requirements are satisfied, and the integrity of the electrorefiner will not be jeopardized during operational and seismic loadings

  16. Structural evaluation in the design of electrorefiner

    International Nuclear Information System (INIS)

    Wu, Ting-shu; Blomquist, C.A.; Herceg, J.E.

    1995-01-01

    The electrorefiner is one piece of the process equipment for the Integral Fast Reactor (IFR) program. Its principal components include a primary vessel, a heater assembly, a support-structure assembly, a cover assembly, four electrode assemblies, four elevator and rotator assemblies, and a cover-gas system. In addition, there are various miscellaneous tools and fixtures. The electrorefiner is to be installed within an existing enclosed cell. Design requirements dictate that all equipment within the cell should not be anchored. To assess the integrity of the electrorefiner during operational and seismic loads, extensive structural analyses have been performed. This paper presents some of the major structural evaluations for the electrorefiner and its auxiliary equipment. Results show that the design code requirements are satisfied, and the integrity of the electrorefiner will not be jeopardized during operational and seismic loadings

  17. Educational Videogames: Concept, Design And Evaluation

    Science.gov (United States)

    Rohrlick, D.; Yang, A.; Kilb, D. L.; Ma, L.; Ruzic, R.; Peach, C. L.; Layman, C. C.

    2013-12-01

    Videogames have historically gained popularity thanks to their entertainment rather than their educational value. This may be due, in part, to the fact that many educational videogames present academic concepts in dry, quiz-like ways, without the visual experiences, interactivity, and excitement of non-educational games. The increasing availability of tools that allow designers to easily create rich experiences for players now makes it simpler than ever for educational game designers to generate the visual experiences, interactivity, and excitement that gamers have grown to expect. Based on data from our work, when designed effectively, educational games can engage players, teach concepts, and tear down the stereotype of the stuffy, boring educational game. Our team has been experimenting with different ways to present scientific and mathematical concepts to middle and high school students through engaging, interactive games. When designing a gameplay concept, we focus on what we want the player to learn and experience as well as how to maintain a learning environment that is fun and engaging. Techniques that we have found successful include the use of a series of fast-paced 'minigames,' and the use of a 'simulator' learning method that allows a player to learn by completing objectives similar to those completed by today's scientists. Formative evaluations of our games over the past year have revealed both design strengths and weaknesses. Based on findings from a systematic evaluation of game play with diverse groups, with data collected through in-person observations of game play, knowledge assessments, focus groups, interviews with players, and computer tracking of students' game play behavior, we have found that players are uniformly enthusiastic about the educational tools. At the same time, we find there is more work to be done to make our tools fully intuitive, and to effectively present complex mathematical and scientific concepts to learners from a wide

  18. Multinational design evaluation programme - 2009 annual report

    International Nuclear Information System (INIS)

    2010-06-01

    The Multinational Design Evaluation Programme (MDEP) was established in 2006 as a multinational initiative to develop innovative approaches to leverage the resources and knowledge of the national regulatory authorities who are currently or will be tasked with the review of new reactor power plant designs. MDEP comprises 13 countries' nuclear regulatory authorities and is structured under 3 design-specific working groups and 3 issue-specific working groups which meet several times a year. The OECD/NEA facilitates MDEP's activities by acting as technical secretariat for the programme. The MDEP Policy Group (PG) and the Steering Technical Committee (STC) oversee the programme. MDEP's main objectives can be defined as follows: - to enhance multilateral co-operation within existing regulatory frameworks; - to encourage multinational convergence of codes, standards and safety goals; - to implement the MDEP products in order to facilitate the licensing of new reactors, including those being developed by the Generation IV International Forum. To carry out the work, two main lines of activity have been implemented: - the exploration of opportunities for harmonisation of regulatory practices; - the cooperation on the safety reviews of specific reactor designs. MDEP engages with key stakeholders involved in ensuring the safety of new reactor designs, manufacturing, construction and operation. At this time, these stakeholders include other national regulatory authorities and international organisations involved in ensuring nuclear safety including the IAEA, Western European Nuclear Regulators' Association (WENRA), NEA Committees on Nuclear Regulatory Activities (CNRA) and Safety of Nuclear Installations (CSNI), the various reactor vendors, nuclear component manufacturers, mechanical and electrical standards development organisations, reactor operators and licensees and key industry representatives such as World Nuclear Association (WNA). To this end, the MDEP has organised a

  19. A rational evaluation of structural design loads

    International Nuclear Information System (INIS)

    Tasaka, S.

    1993-01-01

    The reliability-based seismic design of structures is a design method ensuring that the structural seismic capacity is not less than the maximum seismic load or load effect for a prescribed value of the reliability index, wherein the design reference period, n, is used to specify the n-year maximum load. In the conventional Load and Resistance Factor Design (LRFD) method the design load is commonly determined on the basis of the n-year maximum the probability distribution of which may be given in some different ways. However, in contrast with the structural capacity the n-year maximum load usually involves much larger variabilities. The effort to decrease the variability would, hence, be effective for the purpose of avoiding nuclear power plant (NPP) structures having unnecessarily large capacities. A possible way to do this is to consider the joint probability distribution of the n-year 1st and 2nd maxima of the seismic load derived from the formula of extreme order statistics. Since the reliability index is conventionally associated with the n-year 1st maximum, the conditional probability distribution rather than the joint one of the n-year 1st maximum given a value of the n-year 2nd one will be considered. Three conditional extreme value distributions, which correspond to the usual extreme value distributions of Types I, II and III, and their statistical moments up to the second order are presented. Within the framework of the first-order second moment method, the conditional statistical moments are utilized to calculate the reliability index as well as the design value of the seismic load. The seismic load considered herein is represented by the peak ground acceleration (PGA) in n years. The present scheme is applied to evaluate the design PGA's at II sites in Japan where samples of the annual 1st and 2nd PGA's have been obtained by using historical seismic data. In this application the following two points are of our interest: (a) Define the reliability

  20. Job analysis for training design and evaluation

    International Nuclear Information System (INIS)

    Andersson, H.; Baeck, P.; Wirstad, J.

    1979-01-01

    The report describes a job analysis method which has been used for competency requirements and training evaluation purposes on three jobs in a Swedish nuclear power station. The jobs are the shift supervisor, the reactor operator and the turbine operator. The method is based on a system analytical approach. Through a topdown analysis of the power generation system a structure is derived which is used for an inventory of possible operator tasks. The primary source for actual task generation was interviews with operators and with other personnel who are cooperating with the operators. The method suggests alternative sources for the task generation when operator interviews are not feasible, e.g. in systems which are being developed or when operator experiences are lacking. The result of the job analysis is a set of typical tasks for each job. These tasks represent the contents of the job to be considered in the planning of job training and for recruitment requirements. The same job analysis method was used for training design and evaluation in a Finnish nuclear power station. The concluding remarks of this report are made in the light of this study also. This report is based on a research project B15/77 from the Swedish Nuclear Power Inspectorate. (author)

  1. Richards Barrier LA Reference Design Feature Evaluation

    International Nuclear Information System (INIS)

    N.E. Kramer

    1999-01-01

    The Richards Barrier is one of the design features of the repository to be considered for the License Application (LA), Richards was a soil scientist who first described the diversion of moisture between two materials with different hydrologic properties. In this report, a Richards Barrier is a special type of backfill with a fine-grained material (such as sand) overlaying a coarse-grained material (such as gravel). Water that enters an emplacement drift will first encounter the fine-grained material and be transported around the coarse-grained material covering the waste package, thus protecting the waste package from contact with most of the groundwater. The objective of this report is to discuss the benefits and liabilities to the repository by the inclusion of a Richards Barrier type backfill in emplacement drifts. The Richards Barrier can act as a barrier to water flow, can reduce the waste package material dissolution rate, limit mobilization of the radionuclides, and can provide structural protection for the waste package. The scope of this report is to: (1) Analyze the behavior of barrier materials following the intrusion of groundwater for influxes of 1 to 300 mm per year. The report will demonstrate diversion of groundwater intrusions into the barrier over an extended time period when seismic activity and consolidation may cause the potential for liquefaction and settlement of the Richards Barrier. (2) Review the thermal effects of the Richards Barrier on material behavior. (3) Analyze the effect of rockfall on the performance of the Richards Barrier and the depth of the barrier required to protect waste packages under the barrier. (4) Review radiological and heating conditions on placement of multiple layers of the barrier. Subsurface Nuclear Safety personnel will perform calculations to determine the radiation reduction-time relationship and shielding capacity of the barrier. (5) Evaluate the effects of ventilation on cooling of emplacement drifts and

  2. The Virtual Product-Process Design Laboratory for Structured Chemical Product Design and Analysis

    DEFF Research Database (Denmark)

    Mattei, Michele; Yunus, Nor Alafiza Binti; Kalakul, Sawitree

    2014-01-01

    The objective of this paper is to present new methods for design of chemicals based formulated products and their implementation in the software, the Virtual Product-Process Design Laboratory. The new products are tailor-made blended liquid products and emulsion-based products. The new software...

  3. Contract Design: Risk Management and Evaluation.

    Science.gov (United States)

    Mühlbacher, Axel C; Amelung, Volker E; Juhnke, Christin

    2018-01-12

    Effective risk adjustment is an aspect that is more and more given weight on the background of competitive health insurance systems and vital healthcare systems. The risk structure of the providers plays a vital role in Pay for Performance. A prerequisite for optimal incentive-based service models is a (partial) dependence of the agent's returns on the provider's gain level. Integrated care systems as well as accountable care organisations (ACOs) in the US and similar concepts in other countries are advocated as an effective method of improving the performance of healthcare systems. These systems outline a payment and care delivery model that intends to tie provider reimbursements to predefined quality metrics. By this the total costs of care shall be reduced. Little is known about the contractual design and the main challenges of delegating "accountability" to these new kinds of organisations and/or contracts. The costs of market utilisation are highly relevant for the conception of healthcare contracts; furthermore information asymmetries and contract-specific investments are an obstacle to the efficient operation of ACOs. A comprehensive literature review on methods of designing contracts in Integrated Care was conducted. The research question in this article focuses on how reimbursement strategies, evaluation of measures and methods of risk adjustment can best be integrated in healthcare contracting. Each integrated care contract includes challenges for both payers and providers without having sufficient empirical data on both sides. These challenges are clinical, administrative or financial nature. Risk adjusted contracts ensure that the reimbursement roughly matches the true costs resulting from the morbidity of a population. If reimbursement of care provider corresponds to the actual expenses for an individual/population the problem of risk selection is greatly reduced. The currently used methods of risk adjustment have widely differing model and forecast

  4. Contract Design: Risk Management and Evaluation

    Directory of Open Access Journals (Sweden)

    Axel C. Mühlbacher

    2018-01-01

    Full Text Available Introduction: Effective risk adjustment is an aspect that is more and more given weight on the background of competitive health insurance systems and vital healthcare systems. The risk structure of the providers plays a vital role in Pay for Performance. A prerequisite for optimal incentive-based service models is a (partial dependence of the agent’s returns on the provider’s gain level. Integrated care systems as well as accountable care organisations (ACOs in the US and similar concepts in other countries are advocated as an effective method of improving the performance of healthcare systems. These systems outline a payment and care delivery model that intends to tie provider reimbursements to predefined quality metrics. By this the total costs of care shall be reduced.  Methods: Little is known about the contractual design and the main challenges of delegating “accountability” to these new kinds of organisations and/or contracts. The costs of market utilisation are highly relevant for the conception of healthcare contracts; furthermore information asymmetries and contract-specific investments are an obstacle to the efficient operation of ACOs. A comprehensive literature review on methods of designing contracts in Integrated Care was conducted. The research question in this article focuses on how reimbursement strategies, evaluation of measures and methods of risk adjustment can best be integrated in healthcare contracting.  Results: Each integrated care contract includes challenges for both payers and providers without having sufficient empirical data on both sides. These challenges are clinical, administrative or financial nature. Risk adjusted contracts ensure that the reimbursement roughly matches the true costs resulting from the morbidity of a population. If reimbursement of care provider corresponds to the actual expenses for an individual/population the problem of risk selection is greatly reduced. The currently used methods

  5. CRBRP sodium circulating pump design evaluation

    International Nuclear Information System (INIS)

    Marrujo, F.; Cook, M.; Manners, L.; Cothran, H.

    1977-12-01

    The following topics are discussed: (1) primary sodium pump design concept; (2) pump level control system; (3) resolution of design problems in stress analysis, dynamics analysis, and mechanical design; (4) model testing; (5) planned performance tests; and (6) fabrication status

  6. Multinational Design Evaluation Programme (MDEP) - Safety Goals

    International Nuclear Information System (INIS)

    Vaughan, G.J.

    2011-01-01

    One of the aims of the NEA's Multinational Design Evaluation Programme (MDEP) is to work towards greater harmonisation of regulatory requirements. To achieve this aim, it is necessary that there is a degree of convergence on the safety goals that are required to be met by designers and operators. The term 'safety goals' is defined to cover all health and safety requirements which must be met: these may be deterministic rules and/or probabilistic targets. They should cover the safety of workers, public and the environment in line with the IAEA's Basic Safety Objective; encompassing safety in normal operation through to severe accidents. MDEP is also interested in how its work can be extended to future reactors, which may use significantly different technology to the almost ubiquitous LWRs used today and in the next generation, building on the close co-operation within MDEP between the regulators who are currently engaged in constructing or carrying out design reviews on new designs. For two designs this work has involved several regulators sharing their safety assessments and in some cases issuing statements on issues that need to be addressed. Work is also progressing towards joint regulatory position statements on specific assessment areas. Harmonisation of safety goals will enhance the cooperation between regulators as further developments in design and technology occur. All regulators have safety goals, but these are expressed in many different ways and exercises in comparing them frequently are done at a very low level eg specific temperatures in the reactor vessel of a specific reactor type. The differences in the requirements from different regulators are difficult to resolve as the goals are derived using different principles and assumptions and are often for a specific technology. Therefore a different approach is being investigated, starting with the top-level safety goals and try to derive a structure and means of deriving lower tier

  7. Evaluation criteria for spectral design of camouflage

    Science.gov (United States)

    Škerlind, Christina; Fagerström, Jan; Hallberg, Tomas; Kariis, Hans

    2015-10-01

    In development of visual (VIS) and infrared (IR) camouflage for signature management, the aim is the design of surface properties of an object to spectrally match or adapt to a background and thereby minimizing the contrast perceived by a threatening sensor. The so called 'ladder model" relates the requirements for task measure of effectiveness with surface structure properties through the steps signature effectiveness and object signature. It is intended to link materials properties via platform signature to military utility and vice versa. Spectral design of a surface intends to give it a desired wavelength dependent optical response to fit a specific application of interest. Six evaluation criteria were stated, with the aim to aid the process to put requirement on camouflage and for evaluation. The six criteria correspond to properties such as reflectance, gloss, emissivity, and degree of polarization as well as dynamic properties, and broadband or multispectral properties. These criteria have previously been exemplified on different kinds of materials and investigated separately. Anderson and Åkerlind further point out that the six criteria rarely were considered or described all together in one and same publication previously. The specific level of requirement of the different properties must be specified individually for each specific situation and environment to minimize the contrast between target and a background. The criteria or properties are not totally independent of one another. How they are correlated is part of the theme of this paper. However, prioritization has been made due to the limit of space. Therefore all of the interconnections between the six criteria will not be considered in the work of this report. The ladder step previous to digging into the different material composition possibilities and choice of suitable materials and structures (not covered here), includes the object signature and decision of what the spectral response should be

  8. Evaluation of design parameters of eight dental implant designs: A ...

    African Journals Online (AJOL)

    Aim: Implants could be considered predictable tools for replacing missing teeth or teeth that are irrational to treat. Implant macrodesign includes thread, body shape and thread design. Implant threads should be designed to maximize the delivery of optimal favorable stresses. The aim of this finite element model study was to ...

  9. Mostly efficient as a tailor-made development. A manifold of criteria has to be considered in the selection of tube based heat exchangers; Als Massanfertigung am effizientesten. Bei der Wahl von rohrbasierten Waermeuebertragern ist eine Vielzahl an Kriterien zu beachten

    Energy Technology Data Exchange (ETDEWEB)

    Nobis, Volkhard [GEA Air Treatment Services GmbH, Herne (Germany). Strategische Produktentwicklung

    2010-04-15

    Till to now, heat exchangers can be evaluated only in combination with a central ventilation equipment for example. Contrary to fans or lamps they cannot be classified in favour of a simple selection. Thus, standard solutions are not recommended. For an increased energy efficiency, manufacturers of individually designed central ventilation systems also have to pay attention to the selection and configuration of the heat exchanger to a custom-made design.

  10. Designs for Risk Evaluation and Management

    Energy Technology Data Exchange (ETDEWEB)

    2015-12-01

    The Designs for Risk Evaluation and Management (DREAM) tool was developed as part of the effort to quantify the risk of geologic storage of carbon dioxide (CO2) under the U.S. Department of Energy's National Risk Assessment Partnership (NRAP). DREAM is an optimization tool created to identify optimal monitoring schemes that minimize the time to first detection of CO2 leakage from a subsurface storage formation. DREAM acts as a post-processer on user-provided output from subsurface leakage simulations. While DREAM was developed for CO2 leakage scenarios, it is applicable to any subsurface leakage simulation of the same output format. The DREAM tool is comprised of three main components: (1) a Java wizard used to configure and execute the simulations, (2) a visualization tool to view the domain space and optimization results, and (3) a plotting tool used to analyze the results. A secondary Java application is provided to aid users in converting common American Standard Code for Information Interchange (ASCII) output data to the standard DREAM hierarchical data format (HDF5). DREAM employs a simulated annealing approach that searches the solution space by iteratively mutating potential monitoring schemes built of various configurations of monitoring locations and leak detection parameters. This approach has proven to be orders of magnitude faster than an exhaustive search of the entire solution space. The user's manual illustrates the program graphical user interface (GUI), describes the tool inputs, and includes an example application.

  11. FEDS : A Framework for Evaluation in Design Science Research

    DEFF Research Database (Denmark)

    Venable, John; Pries-Heje, Jan; Baskerville, Richard

    2015-01-01

    Evaluation of design artefacts and design theories is a key activity in Design Science Research (DSR), as it provides feedback for further development and (if done correctly) assures the rigour of the research. However, the extant DSR literature provides insufficient guidance on evaluation...... to enable Design Science Researchers to effectively design and incorporate evaluation activities into a DSR project that can achieve DSR goals and objectives. To address this research gap, this research paper develops, explicates, and provides evidence for the utility of a Framework for Evaluation in Design...... Science (FEDS) together with a process to guide design science researchers in developing a strategy for evaluating the artefacts they develop within a DSR project. A FEDS strategy considers why, when, how, and what to evaluate. FEDS includes a two-dimensional characterisation of DSR evaluation episodes...

  12. A Comprehensive Framework for Evaluation in Design Science Research

    DEFF Research Database (Denmark)

    Pries-Heje, Jan; Baskerville, Richard; Venable, John

    2012-01-01

    Evaluation is a central and essential activity in conducting rigorous Design Science Research (DSR), yet there is surprisingly little guidance about designing the DSR evaluation activity beyond suggesting possible methods that could be used for evaluation. This paper extends the notable exception...... of the existing framework of Pries-Heje et al [11] to address this problem. The paper proposes an extended DSR evaluation framework together with a DSR evaluation design method that can guide DSR researchers in choosing an appropriate strategy for evaluation of the design artifacts and design theories that form...... the output from DSR. The extended DSR evaluation framework asks the DSR researcher to consider (as input to the choice of the DSR evaluation strategy) contextual factors of goals, conditions, and constraints on the DSR evaluation, e.g. the type and level of desired rigor, the type of artifact, the need...

  13. Designing, Implementing, and Evaluating Secure Web Browsers

    Science.gov (United States)

    Grier, Christopher L.

    2009-01-01

    Web browsers are plagued with vulnerabilities, providing hackers with easy access to computer systems using browser-based attacks. Efforts that retrofit existing browsers have had limited success since modern browsers are not designed to withstand attack. To enable more secure web browsing, we design and implement new web browsers from the ground…

  14. Ergonomic evaluation of pilot oxygen mask designs

    NARCIS (Netherlands)

    Lee, W.; Yang, Xiaopeng; Jung, Daehan; Park, Seikwon; Kim, Heeeun; You, Heecheon

    2018-01-01

    A revised pilot oxygen mask design was developed for better fit to the Korean Air Force pilots’ faces. The present study compared an existing pilot oxygen mask and a prototype of the revised mask design with 88 Korean Air Force pilots in terms of subjective discomfort, facial contact pressure,

  15. Evaluation in Design-Oriented Research

    NARCIS (Netherlands)

    Verschuren, P.J.M.; Hartog, R.J.M.

    2005-01-01

    Design has been recognized for a long time both as art and as science. In the sixties of the previous century design-oriented research began to draw the attention of scientific researchers and methodologists, not only in technical engineering but also in the social sciences. However, a rather

  16. Design Concept Evaluation Using System Throughput Model

    International Nuclear Information System (INIS)

    Sequeira, G.; Nutt, W. M.

    2004-01-01

    The U.S. Department of Energy (DOE) Office of Civilian Radioactive Waste Management (OCRWM) is currently developing the technical bases to support the submittal of a license application for construction of a geologic repository at Yucca Mountain, Nevada to the U.S. Nuclear Regulatory Commission. The Office of Repository Development (ORD) is responsible for developing the design of the proposed repository surface facilities for the handling of spent nuclear fuel and high level nuclear waste. Preliminary design activities are underway to sufficiently develop the repository surface facilities design for inclusion in the license application. The design continues to evolve to meet mission needs and to satisfy both regulatory and program requirements. A system engineering approach is being used in the design process since the proposed repository facilities are dynamically linked by a series of sub-systems and complex operations. In addition, the proposed repository facility is a major system element of the overall waste management process being developed by the OCRWM. Such an approach includes iterative probabilistic dynamic simulation as an integral part of the design evolution process. A dynamic simulation tool helps to determine if: (1) the mission and design requirements are complete, robust, and well integrated; (2) the design solutions under development meet the design requirements and mission goals; (3) opportunities exist where the system can be improved and/or optimized; and (4) proposed changes to the mission, and design requirements have a positive or negative impact on overall system performance and if design changes may be necessary to satisfy these changes. This paper will discuss the type of simulation employed to model the waste handling operations. It will then discuss the process being used to develop the Yucca Mountain surface facilities model. The latest simulation model and the results of the simulation and how the data were used in the design

  17. Designing and Evaluating Students' Transformative Learning

    Directory of Open Access Journals (Sweden)

    Nina B. Namaste

    2017-12-01

    Full Text Available Transformative learning hinges on navigating cognitive dissonance; thus, intercultural competency assignments and experiences need to be integrated into study abroad/away courses to help students process and make sense of the cognitive dissonance such an experience provides. Assignments, therefore, need to consciously and intentionally triangulate learning by addressing the read (course readings, the lived/observed (conversations, interactions, activities, excursions, observations about public portrayals of culture, etc., and the compared (home culture vs. host culture. The hope is to improve students’ experiences so that semesters abroad are consistently deep, enriching, and intellectual as opposed to simply an extended tourist sojourn. This article documents the process by which I designed for and assessed, via an in-depth analysis of students’ texts/writings, students’ transformation of their intercultural competency skills and development. In addition, I compared students’ works from two differing semesters to evaluate whether transformation in intercultural competency is inherent in the nature of study abroad or must be explicitly taught and cultivated. My Scholarship of Teaching and Learning (SoTL project corroborated the almost ten years of research that confirm our fears: exposure to another culture is not enough; studying and living abroad does not necessarily lead to increased intercultural learning. Meaningful, integrative, “learning-laden,” and transformative study abroad experiences hinge on students’ ability to make sense of cognitive dissonance. Intercultural competency assignments, therefore, need to be fully and intentionally designed and integrated into such experiences, and evaluated to document such growth. L’apprentissage transformationnel repose sur la manière de naviguer la dissonance cognitive. Par conséquent, les devoirs qui traitent de la compétence interculturelle ainsi que les expériences n

  18. Study design considerations in evaluating environmental impacts

    Science.gov (United States)

    Stan T. Lebow; Paul A. Cooper; Patricia Lebow

    2006-01-01

    The purpose of this chapter is to make the reader aware of how choices in study parameters may influence the outcome of treated-wood environmental impact evaluations. Evaluation of the leaching and environmental accumulation of preservatives from treated wood is a complex process. and many factors can influence the results of such studies. In laboratory studies, the...

  19. Evaluating Plot Designs for the Tropics

    Science.gov (United States)

    Paul C. van Deusen; Bruce Bayle

    1991-01-01

    Theory and procedures are reviewed for determining the best type of plot for a given forest inventory. A general methodology is given that clarifies the relationship between different plot designs and the associated methods to produce the inventory estimates.

  20. Parametric evaluation of an SMR design domain

    International Nuclear Information System (INIS)

    Al Rashdan, Ahmad; Tsvetkov, Pavel

    2015-01-01

    Highlights: • The design of nuclear reactors involves a large set of highly coupled variables. • The effects of 14 variables on 6 SMR performance characteristics was researched. • Screening and sensitivity analyses were applied to decouple the variables’ effects. • Significantly simpler system models were generated, enabling simple optimization. - Abstract: The complex and coupled behavior of the variables that affect the currently developing generation IV reactors and the increase of interest in Small Modular Reactors are major incentives to seek efficient design methods. Instead of the brute force design methodology, often applied to the analysis of nuclear reactors, other more economical and systematic methods should be applied. In a complex system with a high number of variables, it often is necessary to develop models to describe the behavior of each performance characteristic with respect to a set of variables and their interactions. If expensive experiments are needed to develop these models, the number of experiments should be minimized. This can be achieved by designing the experiments to be performed. Once the system’s models are developed, they can be used to decouple the variables’ effects on the performance characteristics and simplify the optimization process. In this article, three screening and sensitivity analysis methods are applied to decouple and understand the effects of fourteen variables on six performance characteristics of a Small Modular Reactor’s design, based on the Advanced Passive (AP-1000) reactor. The application of these methods facilitated the determination of the most important parameters of each performance characteristic, and resulted in several distinctive findings. These findings are applicable to any Light Water Small Modular Reactor that falls within the variables’ design domain

  1. Crew Transportation Technical Standards and Design Evaluation Criteria

    Science.gov (United States)

    Lueders, Kathryn L.; Thomas, Rayelle E. (Compiler)

    2015-01-01

    Crew Transportation Technical Standards and Design Evaluation Criteria contains descriptions of technical, safety, and crew health medical processes and specifications, and the criteria which will be used to evaluate the acceptability of the Commercial Providers' proposed processes and specifications.

  2. Performance evaluation of seal coat materials and designs.

    Science.gov (United States)

    2011-01-01

    "This project presents an evaluation of seal coat materials and design method. The primary objectives of this research are 1) to evaluate seal coat performance : from various combinations of aggregates and emulsions in terms of aggregate loss; 2) to ...

  3. Evaluating the Physiological and Perceptual Responses of Wearing a Newly Designed Cooling Vest for Construction Workers.

    Science.gov (United States)

    Zhao, Yijie; Yi, Wen; Chan, Albert P C; Wong, Francis K W; Yam, Michael C H

    2017-08-01

    Construction workers are subjected to heat stress because of the hot environment, physically demanding tasks, and/or personal protective equipment. A tailor-made cooling vest that protects construction workers from heat-related injuries was developed. The purpose of the study is to examine a newly designed cooling vest's effectiveness in alleviating physiological and perceptual strain in a hot and humid environment. Twelve male participants performed two trials, i.e., cooling vest (VEST) and control (CON) in a climatic chamber controlled at 37°C temperature, 60% relative humidity, 0.3 m/s air velocity, and 450 W/m2 solar radiation to simulate the summer working environment of construction sites. Two bouts of treadmill exercise intermitted with 30-minute passive recovery were designed to simulate the practical work-rest schedule of the construction industry. The cooling vest was used during the passive recovery period in the VEST condition, and the results were compared with that of no cooling vest in the CON condition. The results revealed that the newly designed cooling vest can significantly alleviate heat strain and improve thermal comfort, based on the decrease in body temperature, heart rate, and subjective perceptions (including perceived exertion, thermal, wetness, and comfort sensation) of the participants. It can also prolong work duration in the subsequent exercise. The cooling countermeasures proposed in this study will be able to provide an effective solution in situations that involve repeated bouts of outdoor construction work. © The Author 2017. Published by Oxford University Press on behalf of the British Occupational Hygiene Society.

  4. Design, Construction and Performance Evaluation of Multiple ...

    African Journals Online (AJOL)

    The complex casting machine has been designed to perform the following techniques: gravity casting, stir casting, squeeze casting, vacuum casting, compocasting and thixoforming. All these casting techniques have been integrated into this complex casting machine as different units which work with the help of automation.

  5. Arthroscopic sheath design and technical evaluation

    NARCIS (Netherlands)

    Tuijthof, Gabriëlle J. M.; Blankevoort, Leendert; Herder, Just L.; van Dijk, C. Niek

    2009-01-01

    The maintenance of a clear view on the operation area is essential to perform a minimally invasive procedure In arthroscopy, this is achieved by irrigating the Joint with a saline fluid that is pumped through the joint At present the arthroscopic sheaths are not designed for optimal irrigation,

  6. User Evaluation of Neonatology Ward Design.

    Science.gov (United States)

    Trujillo, Juan Luis Higuera; Aviñó, Antoni Montañana I; Millán, Carmen Llinares

    2017-01-01

    The object of this article is to identify the set of affective and emotional factors behind users' assessments of a space in a neonatology unit and to propose design guidelines based on these. The importance of the neonatology service and the variety of users place great demands on the space at all levels. Despite the repercussions, the emotional aspects of the environment have received less attention. To avoid incurring limitations in the user mental scheme, this study uses two complementary methodologies: focus group and semantic differential. The (qualitative) focus group methodology provides exploratory information and concepts. The (quantitative) semantic differential methodology then uses these concepts to extract the conceptual structures that users employ in their assessment of the space. Of the total 175 subjects, 31 took part in focus groups and 144 in semantic differential. Five independent concepts were identified: privacy, functionality and professional nature, spaciousness, lighting, and cleanliness. In relation to the importance of the overall positive assessment of the space, the perception of privacy and sensations of dominance and pleasure are fundamental. Six relevant design aspects were also identified: provide spacious surroundings, facilitate sufficient separation between the different posts or cots, use different colors from those usually found in health-care centers, as some aversion was found to white and especially green, design areas with childhood themes, use warm artificial light, and choose user-friendly equipment. Results provide design recommendations of interest and show the possibilities offered by combining both systems to analyze user response.

  7. CEPIAH, a method for Evaluation and Design of Pedagogical Hypermedia

    OpenAIRE

    Trigano , Philippe; Pacurar Giacomini , Ecaterina

    2004-01-01

    We are working on a method, called CEPIAH. We propose a web based system used to help teachers to design multimedia documents and to evaluate their prototypes. Our tool integrates two modules such as EMPI (Evaluation of Multimedia Pedagogical and Interactive software), and SP/UL/FC, a method for designing pedagogical hypermedia. The EMPI module is used to evaluate multimedia software used in educational context. We structured a knowledge base composed of a list of evaluation criteria, grouped...

  8. Comprehensive evaluation method in application of nuclear DCS product design

    International Nuclear Information System (INIS)

    Wang Weixin; Zhao Zhemin; Shi Yingbin

    2014-01-01

    In order to select the best design proposal in short time, the TOPSIS comprehensive evaluation method in the nuclear power plant DCS product design was introduced. It can intuitively show the different design proposals good or not good by data and shorten the time of the design proposal optimization. The design proposal selected by this method will be more reasonable and has good comprehensive performance indexes. The TOPSIS comprehensive evaluation method achieves good result in one of the nuclear power plant DCS cabinet design proposal optimization. (authors)

  9. Extension Sustainability Camp: Design, Implementation, and Evaluation

    Science.gov (United States)

    Brain, Roslynn; Upton, Sally; Tingey, Brett

    2015-01-01

    Sustainability Camps provide an opportunity for Extension educators to be in the forefront of sustainability outreach and to meet the growing demand for sustainability education. This article shares development, implementation, and evaluation of an Extension Sustainability Camp for youth, grades 4-6. Camp impact was measured via daily pre-and…

  10. Usability evaluations in user-centred design

    NARCIS (Netherlands)

    Ruyter, de B.E.R.; Vet, de J.H.M.

    1997-01-01

    Improving usability of consumer applications has been the focus of much research. Estimating the advantage of these efforts, however, still is very cumbersome since evaluating product improvements in terms of their usability requires good measuring methods and tools. In this paper activities in the

  11. [The evaluation of academic emergency department design].

    Science.gov (United States)

    Deniz, Turgut; Aydinuraz, Kuzey; Oktay, Cem; Saygun, Meral; Ağalar, Fatih

    2007-01-01

    In our study which was based upon a questionnaire, the inner and outer architectural designs of emergency services of Emergency Medicine Departments were investigated. In this descriptive study, a standard questionnaire was sent to 26 Emergency Medicine Departments which were operating at that time. In the questionnaire, the internal, external architectural and functional features were questioned. Answers of 22 Emergency Medicine Departments were analysed. Two Emergency Medicine Departments that were not operating at that time were not included in the study. The analysis of the replies revealed that only 59% (n=13) of the Emergency Medicine Departments were designed as an emergency service prior to the construction. The ambulance parking areas were not suitable in 77% of the emergency units while only 54.5% (n=12) had protection against adverse weather conditions. In only 59% (n=13) of the emergency units, a triage unit was present and in only one of the in only one (4.5%), a decontamination room was available. It was understood that only 32% (n=8) of the emergency units were appropriate in enlarging their capacity taking the local risk factors into consideration. There was a toilette for disabled patients in only 18% (n=4) of the units as well. Considering a 12-year of history of the Emergency Medicine in Turkey, the presence of a lecture room is still 68% (n=15) in emergency departments which reflects that academic efforts in this field is emerging in challenging physical conditions. The results of our study revealed that emergency service architecture was neglected in Turkey and medical care given was precluded by the insufficient architecture. The design of emergency services has to be accomplished under guidance of scientific data and rules taking advices of architects who have knowledge and experience on this field.

  12. Nonexpert Evaluations on Architectural Design Creativity across Cultures

    Science.gov (United States)

    Hong, Seung Wan; Lee, Jae Seung

    2015-01-01

    This article examines the relationship between cultural differences and the nonexpert evaluations of architectural design creativity. In study I, Caucasian Americans (N = 126) and East Asians (N = 137), who did not major in architecture and urban design, evaluated the novelty and appropriateness of 5 unusual architectural shapes, selected by 5…

  13. Waste disposal technologies: designs and evaluations

    International Nuclear Information System (INIS)

    Shaw, R.A.

    1987-01-01

    Many states and compacts are presently in the throes of considering what technology to select for their low level waste disposal site. Both the technical and economic aspects of disposal technology are important considerations in these decisions. It is also important that they be considered in the context of the entire system. In the case of a nuclear power plant, that system encompasses the various individual waste streams that contain radioactivity, the processing equipment which reduces the volume and/or alters the form in which the radioisotopes are contained, the packaging of the processed wastes in shipment, and finally its disposal. One further part of this is the monitoring that takes place in all stages of this operation. This paper discusses the results of some research that has been sponsored by EPRI with the principal contractor being Rogers and Associates Engineering Corporation. Included is a description of the distinguishing features found in disposal technologies developed in a generic framework, designs for a selected set of these disposal technologies and the costs which have been derived from these designs. In addition, a description of the early efforts towards defining the performance of these various disposal technologies is described. 5 figures, 1 table

  14. Evaluating camouflage design using eye movement data.

    Science.gov (United States)

    Lin, Chiuhsiang Joe; Chang, Chi-Chan; Lee, Yung-Hui

    2014-05-01

    This study investigates the characteristics of eye movements during a camouflaged target search task. Camouflaged targets were randomly presented on two natural landscapes. The performance of each camouflage design was assessed by target detection hit rate, detection time, number of fixations on display, first saccade amplitude to target, number of fixations on target, fixation duration on target, and subjective ratings of search task difficulty. The results showed that the camouflage patterns could significantly affect the eye-movement behavior, especially first saccade amplitude and fixation duration, and the findings could be used to increase the sensitivity of the camouflage assessment. We hypothesized that the assessment could be made with regard to the differences in detectability and discriminability of the camouflage patterns. These could explain less efficient search behavior in eye movements. Overall, data obtained from eye movements can be used to significantly enhance the interpretation of the effects of different camouflage design. Copyright © 2013 Elsevier Ltd and The Ergonomics Society. All rights reserved.

  15. Seismic design and evaluation criteria based on target performance goals

    International Nuclear Information System (INIS)

    Murray, R.C.; Nelson, T.A.; Kennedy, R.P.; Short, S.A.

    1994-04-01

    The Department of Energy utilizes deterministic seismic design/evaluation criteria developed to achieve probabilistic performance goals. These seismic design and evaluation criteria are intended to apply equally to the design of new facilities and to the evaluation of existing facilities. In addition, the criteria are intended to cover design and evaluation of buildings, equipment, piping, and other structures. Four separate sets of seismic design/evaluation criteria have been presented each with a different performance goal. In all these criteria, earthquake loading is selected from seismic hazard curves on a probabilistic basis but seismic response evaluation methods and acceptable behavior limits are deterministic approaches with which design engineers are familiar. For analytical evaluations, conservatism has been introduced through the use of conservative inelastic demand-capacity ratios combined with ductile detailing requirements, through the use of minimum specified material strengths and conservative code capacity equations, and through the use of a seismic scale factor. For evaluation by testing or by experience data, conservatism has been introduced through the use of an increase scale factor which is applied to the prescribed design/evaluation input motion

  16. Design evaluation of the HTGR fuel element size reduction system

    International Nuclear Information System (INIS)

    Strand, J.B.

    1978-06-01

    A fuel element size reduction system for the ''cold'' pilot plant of the General Atomic HTGR Reference Recycle Facility has been designed and tested. This report is both an evaluation of the design based on results of initial tests and a description of those designs which require completion or modification for hot cell use. 11 figures

  17. Evaluating design alternatives using conjoint experiments in virual reality

    NARCIS (Netherlands)

    Dijkstra, J.; Leeuwen, van J.P.; Timmermans, H.J.P.

    2003-01-01

    In this paper the authors describe the design of an experiment based on conjoint measurement that explores the possibility of using the Internet to evaluate design alternatives. These design alternatives are presented as panoramic views, and preferences are measured by asking subjects which

  18. Design and evaluation of the XBT diode

    International Nuclear Information System (INIS)

    Wright, E.L.; Vlieks, A.; Fant, K.; Pearson, C.; Koontz, R.; Jensen, D.; Miram, G.

    1993-01-01

    This paper describes the design and experimental results achieved with the 440 kV, microperveance 1.9, XBT (X-band Beam Tester) diode. The Pierce gun was developed for the 100 MW X-band klystron; the high power RF source to be used on the NLC (Next Linear Collider). The gun is electrostatically focused (no magnetic compression) to a beam diameter of 6.35 mm, with an area convergence of 110:1. Maximum cathode loading is approximately 25 A/cm 2 , with a beam power density of 770 MW/cm 2 . The measured beam current was within 2% of the value predicted by simulation with EGUN. Transmission through the highly instrumented beam tester was 99.98%. Some novel techniques were used to achieve near perfect beam transmission, which include the use of a reentrant-floating input pole piece

  19. Evaluation of urban river landscape design rationality based on AHP

    Directory of Open Access Journals (Sweden)

    Qiao Lifang

    2008-12-01

    Full Text Available An evaluation model for the rationality of the landscape design of urban rivers was established with the analytic hierarchy process (AHP method so as to provide a foundation for updating the landscape design of urban rivers. The evaluation system was divided into four layers, including the target layer, the comprehensive layer, the element layer, and the index layer. Each layer was made of different indices. The evaluation standards for each index were also given in this paper. This evaluation model was proved tenable through its application to the landscape design rationality evaluation of the Weihe River in Xinxiang City of Henan Province. The results show that the water quality, space, activity, facility, community, width of vegetation, sense of beauty and water content are among the most influential factors and should be considered the main basis for evaluating the rationality of the landscape design of urban rivers.

  20. Training Software Developers and Designers to Conduct Usability Evaluations

    Science.gov (United States)

    Skov, Mikael Brasholt; Stage, Jan

    2012-01-01

    Many efforts to improve the interplay between usability evaluation and software development rely either on better methods for conducting usability evaluations or on better formats for presenting evaluation results in ways that are useful for software designers and developers. Both of these approaches depend on a complete division of work between…

  1. Evaluation of Interactive Website Design Indicators for e-Entrepreneurship

    OpenAIRE

    Chih-Chao Chung; Li-Chung Chao; Chin-Hui Chen; Shi-Jer Lou

    2016-01-01

    Using an analytic network process (ANP) as an analytical tool, this study aims to construct an ANP evaluation model of interactive website design indicators. Through a review of the literature, interactive website design of e-entrepreneurship is generalized to the following dimensions: (1) Design; (2) Checking; (3) Service; (4) Interactive; and (5) Promotion, including 19 design indicators. The research is conducted for a case company. According to the findings, the model helps the case compa...

  2. Grouping of the design issues for KNGR MMI evaluation

    International Nuclear Information System (INIS)

    Oh, In Seok; Lee, Dong Young; Lee, Jung Woon; Lee, Hyn Chul; Park, Jae Chang

    2001-05-01

    The Korean Next Generation Reactor(KNGR) man-machine interface(MMI) design adopting digital technologies has been developed since 1997. The KNGR MMI consists of CRT-based operator workstations, large display panel(LDP), alarm System, soft control and computerized procedure system. Westinghouse tried to systematically identify and evaluate human factor potential issues of advanced control room. The KNGR MMI design features are very similar with those of the Westinghouse AP-600. The KNGR will try to reflect the evaluation results of 15 issues that the Westinghouse has developed. But it needs much time and costs to evaluate the 15 issues during this design phase. In this study, we analyzed evaluation issues of the AP-600 and classified the 13 issues, which the Westinghouse developed, into 5 groups to simultaneously except 2 issues which can not evaluate in this design phase

  3. Oil-points - Designers means to evaluate sustainability of concepts

    DEFF Research Database (Denmark)

    Bey, Niki; Lenau, Torben Anker

    1998-01-01

    Designers have an essential influence on product design and are therefore one target group for environmental evaluation methods. This implies, that such evaluation methods have to meet designers requirements. Evaluation of sustainability of products is often done using formal Life Cycle Assessment....... This is investigated by means of three case studies where environmental impact is estimated using the EDIP method, the Eco-indicator 95 method, and the Oil Point method proposed by the authors. It is found that the results obtained using Oil Points are in acceptable conformity with the results obtained with more...

  4. Evaluating hospital design from an operations management perspective.

    Science.gov (United States)

    Vos, Leti; Groothuis, Siebren; van Merode, Godefridus G

    2007-12-01

    This paper describes an evaluation method for the assessment of hospital building design from the viewpoint of operations management to assure that the building design supports the efficient and effective operating of care processes now and in the future. The different steps of the method are illustrated by a case study. In the case study an experimental design is applied to assess the effect of used logistical concepts, patient mix and technologies. The study shows that the evaluation method provides a valuable tool for the assessment of both functionality and the ability to meet future developments in operational control of a building design.

  5. 40 CFR 63.2354 - What performance tests, design evaluations, and performance evaluations must I conduct?

    Science.gov (United States)

    2010-07-01

    ... evaluations, and performance evaluations must I conduct? 63.2354 Section 63.2354 Protection of Environment... tests, design evaluations, and performance evaluations must I conduct? (a)(1) For each performance test... procedures specified in subpart SS of this part. (3) For each performance evaluation of a continuous emission...

  6. COMPARISON OF EXPERIMENTAL-DESIGNS COMBINING PROCESS AND MIXTURE VARIABLES .2. DESIGN EVALUATION ON MEASURED DATA

    NARCIS (Netherlands)

    DUINEVELD, C. A. A.; Smilde, A. K.; Doornbos, D. A.

    1993-01-01

    The construction of a small experimental design for a combination of process and mixture variables is a problem which has not been solved completely by now. In a previous paper we evaluated some designs with theoretical measures. This second paper evaluates the capabilities of the best of these

  7. COMPARISON OF EXPERIMENTAL-DESIGNS COMBINING PROCESS AND MIXTURE VARIABLES .2. DESIGN EVALUATION ON MEASURED DATA

    NARCIS (Netherlands)

    DUINEVELD, CAA; SMILDE, AK; DOORNBOS, DA

    The construction of a small experimental design for a combination of process and mixture variables is a problem which has not been solved completely by now. In a previous paper we evaluated some designs with theoretical measures. This second paper evaluates the capabilities of the best of these

  8. Using Models of Cognition in HRI Evaluation and Design

    National Research Council Canada - National Science Library

    Goodrich, Michael A

    2004-01-01

    ...) guide the construction of experiments. In this paper, we present an information processing model of cognition that we have used extensively in designing and evaluating interfaces and autonomy modes...

  9. Modular reconfigurable machine tools: design, control and evaluation

    CSIR Research Space (South Africa)

    Padayachee, J

    2009-11-01

    Full Text Available The reconfigurable manufacturing system (RMS) paradigm encapsulates methodologies that enable manufacturing systems to cope effectively with market and product changes. This research presents the design and evaluation of modular reconfigurable...

  10. Shielding Design and Radiation Shielding Evaluation for LSDS System Facility

    International Nuclear Information System (INIS)

    Kim, Younggook; Kim, Jeongdong; Lee, Yongdeok

    2015-01-01

    As the system characteristics, the target in the spectrometer emits approximately 1012 neutrons/s. To efficiently shield the neutron, the shielding door designs are proposed for the LSDS system through a comparison of the direct shield and maze designs. Hence, to guarantee the radiation safety for the facility, the door design is a compulsory course of the development of the LSDS system. To improve the shielding rates, 250x250 covering structure was added as a subsidiary around the spectrometer. In this study, the evaluations of the suggested shielding designs were conducted using MCNP code. The suggested door design and covering structures can shield the neutron efficiently, thus all evaluations of all conditions are satisfied within the public dose limits. From the Monte Carlo code simulation, Resin(Indoor type) and Tungsten(Outdoor type) were selected as the shielding door materials. From a comparative evaluation of the door thickness, In and Out door thickness was selected 50 cm

  11. Evaluation of technical design of advanced information display(III)

    International Nuclear Information System (INIS)

    Cha, Woo Chang; Jung, Sung Hae; Park, Joon Yong; Kim, Nam Cheol; Park, Soon Hyuk

    2005-02-01

    As the computer technology is highly developed, the mental model of computer users including NPP operators has been changed from analogue display type-based stereotype to digitalized one. Therefore, it is necessary and confident to consider the issues to evaluate system suitability of advanced information display on visual display terminal. This document is intended for providing an updated and expanded set of user-interface guidelines that meet the needs of designing digitalized information display by finding the generic guidelines involving information display design issues, and the relationship among the guidelines. The design issues and resolutions from the finding may provide the cues for the designers and evaluators of the specific man machine interfaces of digitalized devices. The Design Review Supporting System for Advanced Information Display(DReSS-AID) was developed for the practical usage of evaluators-in-field, which was implemented with Hangul version guidelines

  12. Evaluation of technical design of advanced information display(III)

    Energy Technology Data Exchange (ETDEWEB)

    Cha, Woo Chang; Jung, Sung Hae; Park, Joon Yong; Kim, Nam Cheol [Kumoh National Institute of Technology, Gumi (Korea, Republic of); Park, Soon Hyuk [DNT Inc., Daejeon (Korea, Republic of)

    2005-02-15

    As the computer technology is highly developed, the mental model of computer users including NPP operators has been changed from analogue display type-based stereotype to digitalized one. Therefore, it is necessary and confident to consider the issues to evaluate system suitability of advanced information display on visual display terminal. This document is intended for providing an updated and expanded set of user-interface guidelines that meet the needs of designing digitalized information display by finding the generic guidelines involving information display design issues, and the relationship among the guidelines. The design issues and resolutions from the finding may provide the cues for the designers and evaluators of the specific man machine interfaces of digitalized devices. The Design Review Supporting System for Advanced Information Display(DReSS-AID) was developed for the practical usage of evaluators-in-field, which was implemented with Hangul version guidelines.

  13. Designing and evaluating sociability in online video games

    OpenAIRE

    Christou, Georgios; Law, Effie; Geerts, David; Nacke, Lennart; Zaphiris, Panayiotis

    2013-01-01

    The emergence of Online Video Games has led to new ways of socializing with friends. Nowadays a good online game is also associated with the pleasure of socializing and interaction with other players. One cannot play such a game solitarily in a meaningful sense without interacting with the other players. However, there are still no integrated ways of designing and evaluating the inherent sociability of online video games, nor are there methods or guidelines for designing and evaluating social...

  14. Evaluation of Information Requirements of Reliability Methods in Engineering Design

    DEFF Research Database (Denmark)

    Marini, Vinicius Kaster; Restrepo-Giraldo, John Dairo; Ahmed-Kristensen, Saeema

    2010-01-01

    This paper aims to characterize the information needed to perform methods for robustness and reliability, and verify their applicability to early design stages. Several methods were evaluated on their support to synthesis in engineering design. Of those methods, FMEA, FTA and HAZOP were selected...

  15. Peer assessment in university teaching: Evaluating seven course designs

    NARCIS (Netherlands)

    van den Berg, I.|info:eu-repo/dai/nl/288125797; Admiraal, W.|info:eu-repo/dai/nl/120226340; Pilot, A.|info:eu-repo/dai/nl/068350880

    2006-01-01

    Peer assessment in university teaching: evaluating seven course designs Abstract Peer assessment is understood to be an arrangement with students assessing the quality of their fellow students’ writings and giving feedback to each other. This multiple-case study of seven designs of peer assessment

  16. Design Alternative Evaluation No. 3: Post-Closure Ventilation

    International Nuclear Information System (INIS)

    Logan, R.C.

    1999-01-01

    The objective of this study is to provide input to the Enhanced Design Alternatives (EDA) for License Application Design Selection (LADS). Its purpose is to develop and evaluate conceptual designs for post-closure ventilation alternatives that enhance repository performance. Post-closure ventilation is expected to enhance repository performance by limiting the amount of water contacting the waste packages. Limiting the amount of water contacting the waste packages will reduce corrosion

  17. Peer assessment in university teaching: Evaluating seven course designs

    OpenAIRE

    van den Berg, I.; Admiraal, W.; Pilot, A.

    2006-01-01

    Peer assessment in university teaching: evaluating seven course designs Abstract Peer assessment is understood to be an arrangement with students assessing the quality of their fellow students’ writings and giving feedback to each other. This multiple-case study of seven designs of peer assessment focuses on the contribution of peer assessment to the acquisition of undergraduates’ writing skills. Its aim is to arrive at an optimal design of peer assessment. Factors included in this study are:...

  18. The Design and Evaluation of Teaching Experiments in Computer Science.

    Science.gov (United States)

    Forcheri, Paola; Molfino, Maria Teresa

    1992-01-01

    Describes a relational model that was developed to provide a framework for the design and evaluation of teaching experiments for the introduction of computer science in secondary schools in Italy. Teacher training is discussed, instructional materials are considered, and use of the model for the evaluation process is described. (eight references)…

  19. Evaluating Online Dialogue on "Security" Using a Novel Instructional Design

    Science.gov (United States)

    Arora, Payal

    2008-01-01

    This paper explores evaluation strategies to gauge the impact of a novel instructional design on international community participation online. This is done by conceptualizing and devising indicators for measuring "engagement" online amongst marginalized adult communities worldwide. In doing so, a review of online evaluation literature is…

  20. Evaluation of three coding schemes designed for improved data communication

    Science.gov (United States)

    Snelsire, R. W.

    1974-01-01

    Three coding schemes designed for improved data communication are evaluated. Four block codes are evaluated relative to a quality function, which is a function of both the amount of data rejected and the error rate. The Viterbi maximum likelihood decoding algorithm as a decoding procedure is reviewed. This evaluation is obtained by simulating the system on a digital computer. Short constraint length rate 1/2 quick-look codes are studied, and their performance is compared to general nonsystematic codes.

  1. Expert systems for space power supply: design, analysis, and evaluation

    International Nuclear Information System (INIS)

    Cooper, R.S.; Thomson, M.K.; Hoshor, A.

    1987-01-01

    The authors evaluated the feasibility of applying expert systems to the conceptual design, analysis, and evaluation of space power supplies in particular, and complex systems in general. To do this, they analyzed the space power supply design process and in associated knowledge base, and characterized them in a form suitable for computer emulation of a human expert. The existing expert system tools and the results achieved with them were evaluated to assess their applicability to power system design. They applied some new concepts for combining program architectures (modular expert systems and algorithms) with information about the domain to create a deep system for handling the complex design problem. They authors developed, programmed and tested NOVICE, a code to solve a simplified version of a scoping study of a wide variety of power supply types for a broad range of missions, as a concrete feasibility demonstration

  2. Expert System Approach For Generating And Evaluating Engine Design Alternatives

    Science.gov (United States)

    Shen, Stewart N. T.; Chew, Meng-Sang; Issa, Ghassan F.

    1989-03-01

    Artificial intelligence is becoming an increasingly important subject of study for computer scientists, engineering designers, as well as professionals in other fields. Even though AI technology is a relatively new discipline, many of its concepts have already found practical applications. Expert systems, in particular, have made significant contributions to technologies in such fields as business, medicine, engineering design, chemistry, and particle physics. This paper describes an expert system developed to aid the mechanical designer with the preliminary design of variable-stroke internal-combustion engines. The expert system accomplished its task by generating and evaluating a large number of design alternatives represented in the form of graphs. Through the application of structural and design rules directly to the graphs, optimal and near optimal preliminary design configurations of engines are deduced.

  3. Evaluation of Interactive Website Design Indicators for e-Entrepreneurship

    Directory of Open Access Journals (Sweden)

    Chih-Chao Chung

    2016-04-01

    Full Text Available Using an analytic network process (ANP as an analytical tool, this study aims to construct an ANP evaluation model of interactive website design indicators. Through a review of the literature, interactive website design of e-entrepreneurship is generalized to the following dimensions: (1 Design; (2 Checking; (3 Service; (4 Interactive; and (5 Promotion, including 19 design indicators. The research is conducted for a case company. According to the findings, the model helps the case company review its current execution of interactive website design indicators and the experts’ opinions of the importance of interactive website design indicators. In addition, by comprehensive comparison, it confirms key design indicators and analyzes the managerial implications to help the case company set up precise strategic planning and resource distribution to enhance corporate operational performance and competitiveness.

  4. Evaluation of technical design of advanced information display

    Energy Technology Data Exchange (ETDEWEB)

    Cha, Woo Chang; Kang, Young Ju; Ji, Jung Hun; Jang, Sung Pil; Jung, Sung Hae [Kumoh National Institute of Technology, Gumi (Korea, Republic of)

    2003-03-15

    The performance of human machine system such as nuclear power plant is highly dependent on the suitability of the interface design of the system. As the computer technology is highly developed, the mental model of computer users including NPP operators has been changed from analogue display type-based stereotype to digitalized one. Therefore, it is necessary and confident to consider the issues to evaluate system suitability of advanced information display on CRT or CBP (Computer Based Procedure). This document is intended for providing an updated and expanded set of user-interface guidelines that meet the needs of designing information display on CRT by finding the generic guidelines involving information display design issues as much as possible. The design Issues and resolutions from the finding may provide the cues for the designers and evaluators of the specific man machine interfaces of digitalized devices.

  5. Evaluation of technical design of advanced information display

    International Nuclear Information System (INIS)

    Cha, Woo Chang; Kang, Young Ju; Ji, Jung Hun; Jang, Sung Pil; Jung, Sung Hae

    2003-03-01

    The performance of human machine system such as nuclear power plant is highly dependent on the suitability of the interface design of the system. As the computer technology is highly developed, the mental model of computer users including NPP operators has been changed from analogue display type-based stereotype to digitalized one. Therefore, it is necessary and confident to consider the issues to evaluate system suitability of advanced information display on CRT or CBP (Computer Based Procedure). This document is intended for providing an updated and expanded set of user-interface guidelines that meet the needs of designing information display on CRT by finding the generic guidelines involving information display design issues as much as possible. The design Issues and resolutions from the finding may provide the cues for the designers and evaluators of the specific man machine interfaces of digitalized devices

  6. Evaluation report(1): on design criteria for KALIMER metal fuel

    Energy Technology Data Exchange (ETDEWEB)

    Hwang, Woan; Lee, Byoung Oon; Kim, Young Il

    2001-04-01

    Fuel rods, assembly ducts and their components in KALIMER should be designed to maintain the integrities and to assure their reliable in-reactor performances under the steady state and operational transient conditions which are included in design basis category. And the fuel system must be designed with enough engineering margin to minimize and prevent the failures under ab-normal operational condition, like an accident.In this report, some design limits and the criteria for the fuel assembly ducts for KALIMER are driven by evaluating the irradiation data of metallic fuel based on experimental data from ANL in USA, CRIEPI in Japan and RIAR in Russia.

  7. Evaluation report(1): on design criteria for KALIMER metal fuel

    International Nuclear Information System (INIS)

    Hwang, Woan; Lee, Byoung Oon; Kim, Young Il

    2001-04-01

    Fuel rods, assembly ducts and their components in KALIMER should be designed to maintain the integrities and to assure their reliable in-reactor performances under the steady state and operational transient conditions which are included in design basis category. And the fuel system must be designed with enough engineering margin to minimize and prevent the failures under ab-normal operational condition, like an accident.In this report, some design limits and the criteria for the fuel assembly ducts for KALIMER are driven by evaluating the irradiation data of metallic fuel based on experimental data from ANL in USA, CRIEPI in Japan and RIAR in Russia

  8. Design and evaluation of physical protection systems of nuclear facilities

    Energy Technology Data Exchange (ETDEWEB)

    An, Jin Soo; Lee, Hyun Chul; Hwang, In Koo; Kwack, Eun Ho; Choi, Yung Myung

    2001-06-01

    Nuclear material and safety equipment of nuclear facilities are required to be protected against any kind of theft or sabotage. Physical protection is one of the measures to prevent such illegally potential threats for public security. It should cover all the cases of use, storage, and transportation of nuclear material. A physical protection system of a facility consists of exterior intrusion sensors, interior intrusion sensors, an alarm assessment and communication system, entry control systems, access delay equipment, etc. The design of an effective physical protection system requires a comprehensive approach in which the designers define the objective of the system, establish an initial design, and evaluate the proposed design. The evaluation results are used to determine whether or not the initial design should be modified and improved. Some modelling techniques are commonly used to analyse and evaluate the performance of a physical protection system. Korea Atomic Energy Research Institute(KAERI) has developed a prototype of software as a part of a full computer model for effectiveness evaluation for physical protection systems. The input data elements for the prototype, contain the type of adversary, tactics, protection equipment, and the attributes of each protection component. This report contains the functional and structural requirements defined in the development of the evaluation computer model.

  9. Ergonomic design and evaluation of new surgical scissors.

    Science.gov (United States)

    Shimomura, Yoshihiro; Shirakawa, Hironori; Sekine, Masashi; Katsuura, Tetsuo; Igarashi, Tatsuo

    2015-01-01

    The purpose of this study is to design a new surgical scissors handle and determine its effectiveness with various usability indices. A new scissors handle was designed that retains the professional grip but has the shapes of the eye rings modified to fit the thumb and ring finger and finger rests for the index and little finger. The newly designed scissors and traditional scissors were compared by electromyography, subjective evaluation and task performance in experiments using cutting and peeling tasks. The newly designed scissors reduced muscle load in both hand during cutting by the closing action, and reduced the muscle load in the left hand during peeling by the opening action through active use of the right hand. In evaluation by surgeons, task performance improved in addition to the decrease in muscle load. The newly designed scissors used in this study demonstrated high usability. A new scissors handle was designed that has the eye rings modified to fit the thumb and ring finger. The newly designed scissors reduced muscle load and enabled active use of the right hand. In evaluation by surgeons, task performance improved in addition to the decrease in muscle load.

  10. Evaluating a proposed apprach for managing collaborative design in the conceptual design phase

    NARCIS (Netherlands)

    Sebastian, R.

    2006-01-01

    This paper evaluates the findings of prior research on managing collaborative design in the conceptual design phase of a building project. The prior research was explorative. It used several building projects in the Netherlands as case studies - De Resident in The Hague, Nieuw Stadshart in Almere,

  11. Design and evaluation of an integrated safeguards system: principles

    International Nuclear Information System (INIS)

    Markin, J.T.; Coulter, C.A.; Gutmacher, R.G.; Whitty, W.J.

    1984-07-01

    An integrated safeguards system is defined as a collection of safeguards activities in which system components are coordinated to meet safeguards objectives efficiently within constraints imposed by safeguards resources, facility operations, potential adversaries, and regulatory requirements. This paper describes principles for designing and evaluating an integrated safeguards system that consists of four parts: (1) a problem definition phase that specifies resources and constraints composing the problem boundary values; (2) a system analysis/synthesis phase that describes how to select and integrate safeguards activities for efficient attainment of system objectives; (3) a system evaluation/optimization phase that defines measures of safeguards performance and develops methods for evaluating them; and (4) a decision-making phase that develops principles for selecting admissible designs and preference-ordering designs. 6 references, 4 figures, 5 tables

  12. Design and evaluation of an integrated safeguards system: principles

    International Nuclear Information System (INIS)

    Markin, J.T.; Coulter, C.A.; Gutmacher, R.G.; Whitty, W.J.

    1984-01-01

    An integrated safeguards system is defined as a collection of safeguards activities in which system components are coordinated to meet safeguards objectives efficiently within constraints imposed by safeguards resources, facility operations, potential adversaries, and regulatory requirements. This paper describes principles for designing and evaluating an integrated safeguards system that consists of four parts: a problem definition phase that specifies resources and constraints composing the problem boundary values, a system analysis/synthesis phase that describes how to select and integrate safeguards activities for efficient attainment of system objectives, a system evaluation/optimization phase that defines measures of safeguards performance and develops methods for evaluating them, and a decision-making phase that develops principles for selecting admissible designs and preference-ordering designs

  13. PGSFR Core Thermal Design Procedure to Evaluate the Safety Margin

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Sun Rock; Kim, Sang-Ji [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2014-10-15

    The Korea Atomic Energy Research Institute (KAERI) has performed a SFR design with the final goal of constructing a prototype plant by 2028. The main objective of the SFR prototype plant is to verify the TRU metal fuel performance, reactor operation, and transmutation ability of high-level wastes. The core thermal design is to ensure the safe fuel performance during the whole plant operation. Compared to the critical heat flux in typical light water reactors, nuclear fuel damage in SFR subassemblies arises from a creep induced failure. The creep limit is evaluated based on the maximum cladding temperature, power, neutron flux, and uncertainties in the design parameters, as shown in Fig. 1. In this work, the core thermal design procedures are compared to verify the present PGSFR methodology based on the nuclear plant design criteria/guidelines and previous SFR thermal design methods. The PGSFR core thermal design procedure is verified based on the nuclear plant design criteria/guidelines and previous methods in LWRs and SFRs. The present method aims to directly evaluate the fuel cladding failure and to assure more safety margin. The 2 uncertainty is similar to 95% one-side tolerance limit of 1.96 in LWRs. The HCFs, ITDP, and MCM reveal similar uncertainty propagation for cladding midwall temperature for typical SFR conditions. The present HCFs are mainly employed from the CRBR except the fuel-related uncertainty such as an incorrect fuel distribution. Preliminary PGSFR specific HCFs will be developed by the end of 2015.

  14. Evaluation of technical design of advanced information display(II)

    International Nuclear Information System (INIS)

    Cha, Woo Chang; Kang, Young Ju; Ji, Jung Hun; Jang, Sung Pil; Jung, Sung Hae; Park, Hyun Jin

    2004-02-01

    As the computer technology is highly developed, the mental model of computer users including NPP operators has been changed from analogue display type-based stereotype to digitalized one. Therefore, it is necessary and confident to consider the issues to evaluate system suitability of advanced information display on visual display terminal such as CRT. This document is intended for providing an updated and expanded set of user-interface guidelines that meet the needs of designing information display on CRT by finding the generic guidelines involving information display design issues, and the relationship among the guidelines. The design issues and resolutions from the finding may provide the cues for the designers and evaluators of the specific man machine interfaces of digitalized devices

  15. Evaluation of RF properties by orifice design for IFMIF RFQ

    International Nuclear Information System (INIS)

    Maebara, Sunao; Sugimoto, Masayoshi

    2005-03-01

    Orifices for the IFMIF RFQ have been designed and fabricated, and RF properties have been evaluated by a network analyzer. The designed orifices were installed into a vacuum port of the 1.1m-long RFQ mock-up module, and the resonant frequency and the phase difference between cavities were measured for a quadrupole operation mode of TE 210 . It was found that the RF properties are not affected on condition that slit direction with the same direction of current flow at the RFQ wall. Orifice conductance from 0.22 to 0.25 m 3 /sec by nitrogen conversion at room temperature was designed, and an ultimate pressure level of 5x10 -7 [Pa] was evaluated for the 4.1m-long central module for the IFMIF RFQ. It was concluded that the designed orifices are effective for RF properties and vacuum conductance in the IFMIF RFQ. (author)

  16. Performance evaluation and design of flight vehicle control systems

    CERN Document Server

    Falangas, Eric T

    2015-01-01

    This book will help students, control engineers and flight dynamics analysts to model and conduct sophisticated and systemic analyses of early flight vehicle designs controlled with multiple types of effectors and to design and evaluate new vehicle concepts in terms of satisfying mission and performance goals. Performance Evaluation and Design of Flight Vehicle Control Systems begins by creating a dynamic model of a generic flight vehicle that includes a range of elements from airplanes and launch vehicles to re-entry vehicles and spacecraft. The models may include dynamic effects dealing with structural flexibility, as well as dynamic coupling between structures and actuators, propellant sloshing, and aeroelasticity, and they are typically used for control analysis and design. The book shows how to efficiently combine different types of effectors together, such as aero-surfaces, TVC, throttling engines and RCS, to operate as a system by developing a mixing logic atrix. Methods of trimming a vehicle controll...

  17. Evaluation of technical design of advanced information display(II)

    Energy Technology Data Exchange (ETDEWEB)

    Cha, Woo Chang; Kang, Young Ju; Ji, Jung Hun; Jang, Sung Pil; Jung, Sung Hae; Park, Hyun Jin [Kumoh National Univ., Gumi (Korea, Republic of)

    2004-02-15

    As the computer technology is highly developed, the mental model of computer users including NPP operators has been changed from analogue display type-based stereotype to digitalized one. Therefore, it is necessary and confident to consider the issues to evaluate system suitability of advanced information display on visual display terminal such as CRT. This document is intended for providing an updated and expanded set of user-interface guidelines that meet the needs of designing information display on CRT by finding the generic guidelines involving information display design issues, and the relationship among the guidelines. The design issues and resolutions from the finding may provide the cues for the designers and evaluators of the specific man machine interfaces of digitalized devices.

  18. A Standardized Rubric for Evaluating Webquest Design: Reliability Analysis of ZUNAL Webquest Design Rubric

    Science.gov (United States)

    Unal, Zafer; Bodur, Yasar; Unal, Aslihan

    2012-01-01

    Current literature provides many examples of rubrics that are used to evaluate the quality of web-quest designs. However, reliability of these rubrics has not yet been researched. This is the first study to fully characterize and assess the reliability of a webquest evaluation rubric. The ZUNAL rubric was created to utilize the strengths of the…

  19. Evaluating the success of the company designing the TQM System

    OpenAIRE

    Mitreva, Elizabeta; Taskov, Nako

    2014-01-01

    This paper proposes a methodology for evaluating the success of the designed and implemented system for TQM (audit) and its application in some Macedonian companies. Successful application of this methodology can only be achieved if business processes are designed and implemented with optimal utilization of resources, in order to work out the best from the first time, no defects, no loss of time and to the satisfaction of all users. This methodology has found a p...

  20. An estimate and evaluation of design error effects on nuclear power plant design adequacy

    International Nuclear Information System (INIS)

    Stevenson, J.D.

    1984-01-01

    An area of considerable concern in evaluating Design Control Quality Assurance procedures applied to design and analysis of nuclear power plant is the level of design error expected or encountered. There is very little published data 1 on the level of error typically found in nuclear power plant design calculations and even less on the impact such errors would be expected to have on overall design adequacy of the plant. This paper is concerned with design error associated with civil and mechanical structural design and analysis found in calculations which form part of the Design or Stress reports. These reports are meant to document the design basis and adequacy of the plant. The estimates contained in this paper are based on the personal experiences of the author. In Table 1 is a partial listing of the design docummentation review performed by the author on which the observations contained in this paper are based. In the preparation of any design calculations, it is a utopian dream to presume such calculations can be made error free. The intent of this paper is to define error levels which might be expected in a competent engineering organizations employing currently technically qualified engineers and accepted methods of Design Control. In addition, the effects of these errors on the probability of failure to meet applicable design code requirements also are estimated

  1. New knowledge network evaluation method for design rationale management

    Science.gov (United States)

    Jing, Shikai; Zhan, Hongfei; Liu, Jihong; Wang, Kuan; Jiang, Hao; Zhou, Jingtao

    2015-01-01

    Current design rationale (DR) systems have not demonstrated the value of the approach in practice since little attention is put to the evaluation method of DR knowledge. To systematize knowledge management process for future computer-aided DR applications, a prerequisite is to provide the measure for the DR knowledge. In this paper, a new knowledge network evaluation method for DR management is presented. The method characterizes the DR knowledge value from four perspectives, namely, the design rationale structure scale, association knowledge and reasoning ability, degree of design justification support and degree of knowledge representation conciseness. The DR knowledge comprehensive value is also measured by the proposed method. To validate the proposed method, different style of DR knowledge network and the performance of the proposed measure are discussed. The evaluation method has been applied in two realistic design cases and compared with the structural measures. The research proposes the DR knowledge evaluation method which can provide object metric and selection basis for the DR knowledge reuse during the product design process. In addition, the method is proved to be more effective guidance and support for the application and management of DR knowledge.

  2. Feedback from Usability Evaluation to User Interface Design

    DEFF Research Database (Denmark)

    Nielsen, C. M.; Overgaard, M.; Pedersen, M. B.

    2005-01-01

    This paper reports from an exploratory study of means for providing feedback from a usability evaluation to the user interface designers. In this study, we conducted a usability evaluation of a mobile system that is used by craftsmen to register use of time and materials. The results...... and weaknesses of the system. The findings indicate that detailed descriptions of problems and log descriptions of the user's interaction with the system and of system interaction are useful for the designers when trying to understand the usability problems that the users have encountered....

  3. Statistical evaluation of design-error related nuclear reactor accidents

    International Nuclear Information System (INIS)

    Ott, K.O.; Marchaterre, J.F.

    1981-01-01

    In this paper, general methodology for the statistical evaluation of design-error related accidents is proposed that can be applied to a variety of systems that evolves during the development of large-scale technologies. The evaluation aims at an estimate of the combined ''residual'' frequency of yet unknown types of accidents ''lurking'' in a certain technological system. A special categorization in incidents and accidents is introduced to define the events that should be jointly analyzed. The resulting formalism is applied to the development of U.S. nuclear power reactor technology, considering serious accidents (category 2 events) that involved, in the accident progression, a particular design inadequacy. 9 refs

  4. Design and evaluation of daylighting applications of holographic glazings

    Energy Technology Data Exchange (ETDEWEB)

    Papamichael, K.; Ehrlich, C.; Ward, G.

    1996-12-01

    According to the contractual agreement, BTP would develop a computer model of the POC holographic structures and then simulate the performance of alternative designs using the RADIANCE lighting and rendering computer program [Ward 1990]. The RADIANCE model would then be used to evaluate the daylight performance of alternative designs of holographic glazings in a prototypical office space. The simulation process would be validated against actual photometric measurements of holographic glazing samples developed by POC. The results would be used to evaluate the potential for increased electric lighting savings through increased daylight illuminance levels at distances more than 15 ft--20 ft (4.6 m--6.1 m ) from the window wall.

  5. SSFI and SSOMI new method of evaluating design

    International Nuclear Information System (INIS)

    Tolson, G.M.

    1992-01-01

    The NRC has developed a new inspection method which has proven its effectiveness in evaluating design organizations. The new method is used in two types of NRC inspections, Safety System Functional Inspection (SSFI), and Safety System Outage Modification Inspection (SSOMI). The SSFI/SSOMI audits were developed following an event which brought a nuclear power plant close to a core meltdown. That event was caused by a series of problems which would not have been found using conventional methods. The SSFI and SSOMI audits involve intense technical evaluation of a nuclear system to determine wheter the system will function as designed. The SSFI/SSOMI method normally uses eight to fifteen engineers with different fields of expertise to evaluate a system, or a change to a system in the case of a SSOMI. The effectiveness of each engineer's input is amplified in a series of open, questioning, free-wheeling, brainstorming-type team meetings. During the team meetings, all aspects of the audit are controlled by a consensus of the team members. The findings from these new methods are surprisingly consistent, regardless of which organization is audited or which organization performs the audit. This consistency implies a widespread generic weakness in the manner design is being performed. This paper addresses generic findings and recommends increased use of these new methods to evaluate design organizations. These audit methods can be readily used to evaluate any process or system. (orig.)

  6. Analysis and Evaluation of Statistical Models for Integrated Circuits Design

    Directory of Open Access Journals (Sweden)

    Sáenz-Noval J.J.

    2011-10-01

    Full Text Available Statistical models for integrated circuits (IC allow us to estimate the percentage of acceptable devices in the batch before fabrication. Actually, Pelgrom is the statistical model most accepted in the industry; however it was derived from a micrometer technology, which does not guarantee reliability in nanometric manufacturing processes. This work considers three of the most relevant statistical models in the industry and evaluates their limitations and advantages in analog design, so that the designer has a better criterion to make a choice. Moreover, it shows how several statistical models can be used for each one of the stages and design purposes.

  7. Light water reactors fuel assembly mechanical design and evaluation

    International Nuclear Information System (INIS)

    Anon.

    1981-01-01

    This standard establishes a procedure for performing an evaluation of the mechanical design of fuel assemblies for light water-cooled commercial power reactors. It does not address the various aspects of neutronic or thermalhydraulic performance except where these factors impose loads or constraints on the mechanical design of the fuel assemblies. This standard also includes a set of specific requirements for design, various potential performance problems and criteria aimed specifically at averting them. This standard replaces ANSI/ANS-57.5-1978

  8. Evaluation of mini super computers for nuclear design applications

    International Nuclear Information System (INIS)

    Altomare, S.; Baradari, F.

    1987-01-01

    The evolution of the mini super computers will force changes from the current environment of performing nuclear design calculations on mainframe computers (such as a CRAY) to mini super computers. This change will come about for a number of reasons. First, the mini super computers currently available in the marketplace offer the power and speed comparable to mainframes and can provide the capability to support highly computer intensive calculations. Second, the equipment is physically smaller and can easily be installed and operated without extensive investments in facilities and operations support. Third, the computer capacity can be acquired with as much needed memory, disk, and tape capacity as may be needed. Another reasons is that the performance/cost ratio has increased drastically as hardware costs have decreased. A study was conducted at the Westinghouse Commercial Nuclear Fuel Division (CNFD) to evaluate the mini super computers for use in nuclear core design. As a result of this evaluation, Westinghouse CNFD is offering a combined hardware/software technology transfer package for core design. This package provides the utility designer with a totally dedicated mini super computer comparable in speed to the CRAY 1S with sufficient capacity for a sizable design group to perform the engineering activities related to nuclear core design and operations support. This also assures the utility of being totally compatible with the CNFD design codes, thus assuring total update compatibility

  9. High performance APCS conceptual design and evaluation scoping study

    International Nuclear Information System (INIS)

    Soelberg, N.; Liekhus, K.; Chambers, A.; Anderson, G.

    1998-02-01

    This Air Pollution Control System (APCS) Conceptual Design and Evaluation study was conducted to evaluate a high-performance (APC) system for minimizing air emissions from mixed waste thermal treatment systems. Seven variations of high-performance APCS designs were conceptualized using several design objectives. One of the system designs was selected for detailed process simulation using ASPEN PLUS to determine material and energy balances and evaluate performance. Installed system capital costs were also estimated. Sensitivity studies were conducted to evaluate the incremental cost and benefit of added carbon adsorber beds for mercury control, specific catalytic reduction for NO x control, and offgas retention tanks for holding the offgas until sample analysis is conducted to verify that the offgas meets emission limits. Results show that the high-performance dry-wet APCS can easily meet all expected emission limits except for possibly mercury. The capability to achieve high levels of mercury control (potentially necessary for thermally treating some DOE mixed streams) could not be validated using current performance data for mercury control technologies. The engineering approach and ASPEN PLUS modeling tool developed and used in this study identified APC equipment and system performance, size, cost, and other issues that are not yet resolved. These issues need to be addressed in feasibility studies and conceptual designs for new facilities or for determining how to modify existing facilities to meet expected emission limits. The ASPEN PLUS process simulation with current and refined input assumptions and calculations can be used to provide system performance information for decision-making, identifying best options, estimating costs, reducing the potential for emission violations, providing information needed for waste flow analysis, incorporating new APCS technologies in existing designs, or performing facility design and permitting activities

  10. Tailor-made finance versus tailor-made service : Can the state improve consumer choice in healthcare by reforming the financial structure?

    NARCIS (Netherlands)

    K.J. Grit (Kor); A.A. de Bont (Antoinette)

    2010-01-01

    textabstractABSTRACT Background: Policy instruments based on the working of markets have been introduced to empower consumers of healthcare, however it is not easy to become a critical consumer in healthcare. Objectives: The aim of this study is to analyze the possibilities of the state to

  11. Situated Research Design and Methodological Choices in Formative Program Evaluation

    Science.gov (United States)

    Supovitz, Jonathan

    2013-01-01

    Design-based implementation research offers the opportunity to rethink the relationships between intervention, research, and situation to better attune research and evaluation to the program development process. Using a heuristic called the intervention development curve, I describe the rough trajectory that programs typically follow as they…

  12. Designing and evaluating the tabletop game experience for senior citizens

    NARCIS (Netherlands)

    Al Mahmud, A.; Mubin, O.; Shahid, C.S.; Martens, J.B.O.S.

    2008-01-01

    In this paper, we report on the design and evaluation of a tabletop game especially created for senior citizens. The game is intended to provide leisure and fun and is played with four players on an augmented tabletop. It evolved from existing games and rules that are popular and familiar amongst

  13. Improving the Interplay between Usability Evaluation and User Interface Design

    DEFF Research Database (Denmark)

    Hornbæk, K.; Stage, Jan

    2004-01-01

    of the workshop are motivated and an outline of the contents of the papers that were presented in the workshop is given. In addition we summarize some challenges to the interplay between usability evaluation and user interface design agreed upon at the workshop, as well as some solutions that were debated....

  14. Design, implementation, and evaluation of the Resilient Smalltalk embedded platform

    DEFF Research Database (Denmark)

    Andersen, Jacob Robert; Bak, Lars; Grarup, Steffen

    2005-01-01

    machine running on embedded systems. Programmers may connect to running virtual machines and service, monitor, or change the running systems. Furthermore, we present an evaluation of the Resilient platform in relation to the design goals through a case study of two development projects which successfully...

  15. Study Design and Data Gathering Guide for Serious Games’ Evaluation

    NARCIS (Netherlands)

    Baalsrud Hauge, Jannicke; Boyle, Elizabeth; Mayer, Igor; Nadolski, Rob; Riedel, Johann C. K. H.; Moreno-Ger, Pablo; Bellotti, Francesco; Lim, Theodore; Ritchie, James

    2013-01-01

    Baalsrud Hauge, J., Boyle, E., Mayer, I., Nadolski, R. J., Riedel, J. C. K. H., Moreno-Ger, P., Bellotti, F., Lim, T., & Ritchie, J. (2013). Study Design and Data Gathering Guide for Serious Games’ Evaluation. In T. M. Connolly, T. Hainey, E. Boyle, G. Baxter, & P. Moreno-Ger (Eds.), Psychology,

  16. DOE natural phenomenal hazards design and evaluation criteria

    International Nuclear Information System (INIS)

    Murray, R.C.; Nelson, T.A.; Short, S.A.; Kennedy, R.P.; Chander, H.; Hill, J.R.; Kimball, J.K.

    1994-10-01

    It is the policy of the Department of Energy (DOE) to design, construct, and operate DOE facilities so that workers, the general public, and the environment are protected from the impacts of natural phenomena hazards (NPH). Furthermore, DOE has established explicit goals of acceptable risk for NPH performance. As a result, natural phenomena hazard (earthquake, extreme wind, and flood) design and evaluation criteria for DOE facilities have been developed based on target probabilistic performance goals. These criteria include selection of design/evaluation NPH input from probabilistic hazard curves combined with commonly practiced deterministic response evaluation methods and acceptance criteria with controlled levels of conservatism. For earthquake considerations, conservatism is intentionally introduced in specification of material strengths and capacities, in the allowance of limited inelastic behavior, and by a seismic scale factor. Criteria have been developed following a graded approach for several performance goals ranging from that appropriate for normal-use facilities to that appropriate for facilities involving hazardous or critical operations. Performance goals are comprised of qualitative expressions of acceptable behavior and of target quantitative probabilities that acceptable limits of behavior are maintained. The criteria are simple procedures but have a rigorous basis. This paper addresses DOE seismic design and evaluation criteria

  17. Molecular design, synthesis and evaluation of chemical biology tools

    NARCIS (Netherlands)

    Hoogenboom, Jorin

    2017-01-01

    Chapter 1 provides a perspective of synthetic organic chemistry as a discipline involved in the design, synthesis and evaluation of complex molecules. The reader is introduced with a brief history of synthetic organic chemistry, all the while dealing with different aspects of

  18. Design and techno economic evaluation of biomass gasifier for ...

    African Journals Online (AJOL)

    This paper addresses the design, performance and economic evaluation of biomass based open core downdraft gasifier for industrial process heat application. The gasifier is having feed rate as 90 kg h-1 and producing about 850 MJ h-1 of heat. The gasifier has been installed in M/S Phosphate India Pvt. Limited, Udaipur ...

  19. Physiological evaluation of a newly designed lever mechanism for wheelchairs

    NARCIS (Netherlands)

    van der Woude, L H; Veeger, DirkJan (H. E. J.); de Boer, Y; Rozendal, R H

    1993-01-01

    Lever-propelled wheelchairs have been described as more efficient and less physically demanding than hand-rim-propelled wheelchairs. To evaluate a newly designed lever mechanism (MARC) in both one- and two-arm use, a series of wheelchair exercise tests were performed on a motor-driven treadmill.

  20. Designing the model for evaluating business quality in Croatia

    Directory of Open Access Journals (Sweden)

    Ana Ježovita

    2015-01-01

    Full Text Available The main objective of the paper includes designing a model for evaluating the financial quality of business operations. In that context, for the paper purposes, the financial quality of business operations is defined as an ability to achieve adequate value of individual financial ratios for financial position and performance evaluation. The objective of the model is to obtain comprehensive conclusion about the financial quality of business operation using only value of the function. Data used for designing the model is limited to financial data available from the annual balance sheet and income statement. Those limitations offer the opportunity for all sizes of companies from the non-financial business economy sector to use the designed model for evaluation purposes. Statistical methods used for designing the model are multivariate discriminant analysis and logistic regression. Discriminant analysis resulted in the function which includes five individual financial ratios with the best discriminant power. Respecting the results obtained in the classification matrix with classification accuracy of 95.92% by the original sample, or accuracy of 96.06% for the independent sample, it can be concluded that it is possible to evaluate the financial quality of business operations of companies in Croatia by using the model composed of individual financial ratios. Conducted logistic regression confirms the results obtained using discriminant analysis.

  1. Designing, Teaching, and Evaluating Two Complementary Mixed Methods Research Courses

    Science.gov (United States)

    Christ, Thomas W.

    2009-01-01

    Teaching mixed methods research is difficult. This longitudinal explanatory study examined how two classes were designed, taught, and evaluated. Curriculum, Research, and Teaching (EDCS-606) and Mixed Methods Research (EDCS-780) used a research proposal generation process to highlight the importance of the purpose, research question and…

  2. Conceptual design study for the demonstration reactor of JSFR. (3) Safety design and evaluation

    International Nuclear Information System (INIS)

    Tani, Akihiro; Shimakawa, Yoshio; Kubo, Shigenobu; Fujimura, Ken; Yamano, Hidemasa

    2011-01-01

    This paper describes the result of conceptual safety design and evaluation for the demonstration plant of Japan sodium-cooled fast reactor (JSFR), which was preliminarily conducted for providing information necessary to decide the plant specification for further design study. The plant major specifications except for output power and safety design concept are almost the same as those of the commercial JSFR. A set of safety evaluation for typical design basis events (DBEs) is mainly focused here, which was conducted for the 750 MWe design. Safety analyses for DBEs evaluation were performed on the basis of conservative assumptions using a one-dimensional flow network code with point kinetics. For representative DBEs, transient over power type events and loss of flow type events were analyzed. The long-term loss-of-offsite power event was also calculated to evaluate the natural circulation decay heat removal system. All analytical results showed to meet tentative safety criteria, thus it was confirmed that the safety design concept of JSFR is feasible against DBEs. (author)

  3. Improved fuel design economics - a new evaluation tool

    International Nuclear Information System (INIS)

    Aboudara, J.L.

    1987-01-01

    Advanced fuel design technology is now beginning to be implemented with new reload regions for large pressurized water reactors. Until recently there has not been an integrated computer modeling product that would allow easy assessment of the economics of various advanced fuel design alternatives now available to utilities. The Fuel Cycle Scoping System (FCSS) was designed to fill this need. The FCSS is a personnel computer (PC) software package that is used to evaluate alternative strategies for supplying and using nuclear fuel in nuclear power reactors. The FCSS is an extremely flexible package that permits evaluation of in-core and out-of-core fuel management strategy options. For each strategy option, unit and reactor operating assumptions and assumptions for uranium supply, conversion, enrichment, fabrication, and spent fuel disposal can be made

  4. Array design and expression evaluation in POOMA II

    Energy Technology Data Exchange (ETDEWEB)

    Karmesin, S.; Crotinger, J.; Cummings, J.; Haney, S.; Humphrey, W.; Reynders, J.; Smith, S.; Williams, T.J.

    1998-12-31

    POOMA is a templated C++ class library for use in the development of large-scale scientific simulations on serial and parallel computers. POOMA II is a new design and implementation of POOMA intended to add richer capabilities and greater flexibility to the framework. The new design employs a generic Array class that acts as an interface to, or view on, a wide variety of data representation objects referred to as engines. This design separates the interface and the representation of multidimensional arrays. The separation is achieved using compile-time techniques rather than virtual functions, and thus code efficiency is maintained. POOMA II uses PETE, the Portable Expression Template Engine, to efficiently represent complex mathematical expressions involving arrays and other objects. The representation of expressions is kept separate from expression evaluation, allowing the use of multiple evaluator mechanisms that can support nested where-block constructs, hardware-specific optimizations and different run-time environments.

  5. Diabetic Mario: Designing and Evaluating Mobile Games for Diabetes Education.

    Science.gov (United States)

    Baghaei, Nilufar; Nandigam, David; Casey, John; Direito, Artur; Maddison, Ralph

    2016-08-01

    Traditionally, diabetes education has relied on written materials, with limited resources available for children with diabetes. Mobile games can be effective and motivating tools for the promotion of children's health. In our earlier work, we proposed a novel approach for designing computer games aimed at educating children with diabetes. In this article, we apply our game design to a mobile Android game (Mario Brothers). We also introduce four heuristics that are specifically designed for evaluating the mobile game, by adapting traditional usability heuristics. Results of a pilot study (n = 12) to evaluate gameplay over 1-week showed that the children found the game engaging and improved their knowledge of healthy diet and lifestyle.

  6. Technical Details on Beyond Design Basis Event Pilot Evaluations

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2013-01-01

    The primary focus of the BDBE pilot project was the review of BDBE analysis and mitigation features at four DOE nuclear facilities representing a range of DOE sites, nuclear facility types/activities, and responsible program offices. The pilots looked at (1) how beyond design basis accidents were evaluated and documented in the facility Documented Safety Analysis, (2) potential BDBE vulnerabilities and margins to failure of facility safety features as obtained from general area and specific system walkdowns and design documents reviews, and (3) preparations made in facility and site emergency management programs to respond to severe accidents. It also evaluated whether draft BDBE guidance on safety analysis and emergency management could be used to improve the analysis of and preparations for mitigating severe and beyond design basis accidents. The details of these activities are organized in this report as described below.

  7. Requirements of Integrated Design Teams While Evaluating Advanced Energy Retrofit Design Options in Immersive Virtual Environments

    Directory of Open Access Journals (Sweden)

    Xue Yang

    2015-12-01

    Full Text Available One of the significant ways to save energy use in buildings is to implement advanced energy retrofits in existing buildings. Improving energy performance of buildings through advanced energy retrofitting requires a clear understanding of the cost and energy implications of design alternatives from various engineering disciplines when different retrofit options are considered. The communication of retrofit design alternatives and their energy implications is essential in the decision-making process, as it affects the final retrofit selections and hence the energy efficiency of the retrofitted buildings. The objective of the research presented here was to identify a generic list of information requirements that are needed to be shared and collectively analyzed by integrated design teams during advanced energy retrofit design review meetings held in immersive settings. While identifying such requirements, the authors used an immersive environment based iterative requirements elicitation approach. The technology was used as a means to better identify the information requirements of integrated design teams to be analyzed as a group. This paper provides findings on information requirements of integrated design teams when evaluating retrofit options in immersive virtual environments. The information requirements were identified through interactions with sixteen experts in design and energy modeling domain, and validated with another group of participants consisting of six design experts who were experienced in integrated design processes. Industry practitioners can use the findings in deciding on what information to share with integrated design team members during design review meetings that utilize immersive virtual environments.

  8. Evaluation of preconceptual plug designs using experts' judgement

    International Nuclear Information System (INIS)

    Sioshansi, F.P.; O'Rourke, J.E.

    1980-03-01

    A number of preconceptual plug designs for an underground nuclear waste repository were to be evaluated based on the available information on plug materials and placement techniques. Because of complex environment and loading conditions, long time frame under consideration, rigid performance characteristics and considerable uncertainties present in preconceptual design and material properties, a qualitative and judgmental evaluation procedure was needed to supplement technical studies. A structured procedure was developed to qualitatively capture evaluator's views and reservations on the proposed preconceptual schemes. Since a thorough evaluation of each proposed plug scheme required in-depth experience and familiarity with many components of the plug, three knowledgeable experts with specialties in the most relevant aspects of the problem were independently interviewed. Each plug scheme was broken down into three subcomponents and each subcomponent was evaluated separately. The proposed schemes were then rated taking their subcomponents into consideration. Because the experts had different specialties, their subcomponent and overall ratings were not in full agreement. Each plug scheme's lowest overall rating was used as the most significant determinant of the judgmental preference categories reported in this study. The approach used discriminated between the proposed schemes for those with highest probability of being successful. The most preferred schemes were then reviewed with respect to the data produced in the technical analysis performed during the project. The results of the judgmental analysis were then synthesized and modified with results of the technical analysis to produce the preconceptual plug designs

  9. Novel modular natural circulation BWR design and safety evaluation

    International Nuclear Information System (INIS)

    Ishii, Mamoru; Shi, Shanbin; Yang, Won Sik; Wu, Zeyun; Rassame, Somboon; Liu, Yang

    2015-01-01

    Highlights: • Introduction of BWR-type natural circulation small modular reactor preliminary design (NMR-50). • Design of long fuel cycle length for the NMR-50. • Design of double passive safety systems for the NMR-50. • RELAP5 analyses of design basis accidents for the NMR-50. - Abstract: The Purdue NMR (Novel Modular Reactor) represents a BWR-type small modular reactor with a significantly reduced reactor pressure vessel (RPV) height. Specifically, it has one third the height of a conventional BWR RPV with an electrical output of 50 MWe. The preliminary design of the NMR-50 including reactor, fuel cycle, and safety systems is described and discussed. The improved neutronics design of the NMR-50 extends the fuel cycle length up to 10 years. The NMR-50 is designed with double passive engineering safety system, which is intended to withstand a prolonged station black out with loss of ultimate heat sink accident such as experienced at Fukushima. In order to evaluate the safety features of the NMR-50, two representative design basis accidents, i.e. main steam line break (MSLB) and bottom drain line break (BDLB), are simulated by using the best-estimate thermal–hydraulic code RELAP5. The RPV water inventory, containment pressure, and the performance of engineering safety systems are investigated for about 33 h after the initiation of the accidents

  10. Using Concrete and Realistic Data in Evaluating Initial Visualization Designs

    DEFF Research Database (Denmark)

    Knudsen, Søren; Pedersen, Jeppe Gerner; Herdal, Thor

    2016-01-01

    We explore means of designing and evaluating initial visualization ideas, with concrete and realistic data in cases where data is not readily available. Our approach is useful in exploring new domains and avenues for visualization, and contrasts other visualization work, which typically operate...... under the assumption that data has already been collected, and is ready to be visualized. We argue that it is sensible to understand data requirements and evaluate the potential value of visualization before devising means of automatic data collection. We base our exploration on three cases selected...... the design case and problem, the manner in which we collected data, and the findings obtained from evaluations. Afterwards, we describe four factors of our data collection approach, and discuss potential outcomes from it....

  11. Preliminary evaluation of FY98 KALIMER shielding design

    Energy Technology Data Exchange (ETDEWEB)

    Yoo, Jae Woon; Kang, Chang Mu; Kim, Young Jin [Korea Atomic Energy Research Institute, Taejon (Korea)

    1999-01-01

    This report describes a preliminary evaluation of the shielding design of FY98 KALIMER. The KALIMER shielding design includes the Inner Fixed Shield of a stainless cylinder located inside the support barrel; the Radial PSDRS Shields which are three B{sub 4}C cylinders located outside the support barrel at core level; the Lower IHX shield of a cylindrical B{sub 4}C plate located above the flow guide; and Inner and Outer IHX shields of B{sub 4}C cylinders located inside and outside of the support barrel, respectively. The DORT3.1 two-dimensional transport code was used to evaluate the KALIMER shielding design. The reactor system was represented by four axial zones, each of which was modeled in the R-Z geometry. The KAFAX-F22 library was used in the analyses, which was generated from the JEF-2.2 of OECD/NEA files for LMR applications by KAERI. The performance of the KALIMER shielding design is compared against the shielding design criteria. The results indicate that the support barrel, upper grid plate, and other reactor structures meet the maximum neutron fluence and DPA limits established in the shielding design criteria. Activities of the air effluent in the PSDRS were also evaluated and are shown to satisfy the maximum permissible concentration (MPC) limits in 10 CFR Part 20. In the future, the validation of the DORT model by a detailed three dimensional calculation such as MCNP and the justification of the current shielding design limits are needed. (author). 13 refs., 23 figs., 31 tabs.

  12. Evaluation of masonry wall design at nuclear power plants

    International Nuclear Information System (INIS)

    Con, V.N.; Subramonian, N.; Chokshi, N.

    1983-01-01

    The structural integrity of safety-related masonry walls in operating nuclear power plants may not be maintained when subjected to certain loads and load combinations. The paper presents some findings based upon the review of the design and analysis procedures used by the licensees in the reevaluation of safety-related masonry walls. The design criteria developed by the Structural Engineering Branch (SEB) of the United States Nuclear Regulatory Commission (NRC) along with other standard codes such as the Uniform Building Code, ACI 531-79, ATC 3-06, and NCMA were used as guidance in evaluating the design criteria developed by the licensees. The paper deals with the following subject areas: loads and load combinations, allowable stresses, analytical procedures, and modification methods. The paper concludes that, in general, the masonry walls in nuclear power plants comply with the working stress design requirements. In some cases, certain nonlinear analysis methods were used. The applicability of these methods is discussed. (orig.)

  13. Evaluation of design feature No.20 -- Ground support options

    International Nuclear Information System (INIS)

    Duan, F.

    2000-01-01

    Ground support options are primarily evaluated for emplacement drifts while ground support systems for non-emplacement openings such as access mains and ventilation drifts are not evaluated against LADS evaluation criteria in this report. Considerations include functional requirements for ground support, the use of a steel-lined system, and the feasibility of using an unlined ground support system principally with grouted rock bolts for permanent ground support. The feature evaluation also emphasizes the postclosure effects of ground support materials on waste isolation and the preclosure aspects such as durability, maintainability, constructibility, safety, engineering acceptability, and cost. This evaluation is to: (A) Review the existing analyses, reports, and studies regarding this design feature, and compile relevant information on performance characteristics. (B) Develop an appropriate evaluation approach for evaluating ground support options against evaluation criteria provided by the LADS team. (C) Evaluate ground support options not only for their preclosure performance in terms of drift stability, material durability, maintenance, constructibility, and cost, but also for their postclosure performance in terms of chemical effects of ground support materials (i.e., concrete, steel) on waste isolation and radionuclide transport. Specifically, the scope for ground support options evaluation include: (1) all steel-lined drifts (no cementitious materials), (2) unlined drifts with minimum cementitious materials (e.g., grout for rockbolts), and (3) concrete-lined drifts, with the focus on the postclosure acceptability evaluation. In addition, unlined drifts with zero cementitious materials (e.g., use of frictional bolts such as split sets, Swellex bolts) are briefly discussed. (D) Identify candidate ground support systems that have the potential to enhance the repository performance based on the feature evaluation. and (E) Provide conclusions and recommendations

  14. Cross-cultural evaluations of avatar facial expressions designed by Western and Japanese Designers

    DEFF Research Database (Denmark)

    Koda, Tomoko; Rehm, Matthias; André, Elisabeth

    2008-01-01

    The goal of the study is to investigate cultural differences in avatar expression evaluation and apply findings from psychological study in human facial expression recognition. Our previous study using Japanese designed avatars showed there are cultural differences in interpreting avatar facial...... expressions, and the psychological theory that suggests physical proximity affects facial expression recognition accuracy is also applicable to avatar facial expressions. This paper summarizes the early results of the successive experiment that uses western designed avatars. We observed tendencies of cultural...

  15. Evaluation of materials and design modifications for aircraft brakes

    Science.gov (United States)

    Ho, T. L.; Kennedy, F. E.; Peterson, M. B.

    1975-01-01

    A test program is described which was carried out to evaluate several proposed design modifications and several high-temperature friction materials for use in aircraft disk brakes. The evaluation program was carried out on a specially built test apparatus utilizing a disk brake and wheel half from a small het aircraft. The apparatus enabled control of brake pressure, velocity, and braking time. Tests were run under both constant and variable velocity conditions and covered a kinetic energy range similar to that encountered in aircraft brake service. The results of the design evaluation program showed that some improvement in brake performance can be realized by making design changes in the components of the brake containing friction material. The materials evaluation showed that two friction materials show potential for use in aircraft disk brakes. One of the materials is a nickel-based sintered composite, while the other is a molybdenum-based material. Both materials show much lower wear rates than conventional copper-based materials and are better able to withstand the high temperatures encountered during braking. Additional materials improvement is necessary since both materials show a significant negative slope of the friction-velocity curve at low velocities.

  16. Design and Evaluation Methods for Underwater Control Systems

    Energy Technology Data Exchange (ETDEWEB)

    Chi, Lin

    1996-12-31

    This thesis on underwater control systems is written with the designer in mind, assuming that the reader has some knowledge of control theory. It can be used as a text for undergraduate students and engineers. To help readers better understand the system they will be working with, the thesis is organised in a stepwise way. The reader will gain basic knowledge about underwater operations, equipment and control systems. Then the reader will be able to follow the steps to develop a required control system for an underwater equipment by first understanding the characteristics of the design problem, customer requirement, functional requirement, and possible solution, and then to present a mathematical model of the control problem. Having developed the concept, the thesis guides the reader to develop evaluation criteria and different ways to make the decision. The thesis gives an overview of how to achieve a successful design rather than giving the techniques for detailed control system design. Chapter 1 describes underwater operations and systems. Chapter 2 discusses issues of underwater control systems and control methods. Chapter 3 deals with design method and control systems theory, focusing on human-centered control. Chapter 4 discusses methods used to evaluate and rank products, and chapter 5 applies the methods to an example. 113 refs., 115 figs., 80 tabs.

  17. Design and Evaluation Methods for Underwater Control Systems

    Energy Technology Data Exchange (ETDEWEB)

    Chi, Lin

    1997-12-31

    This thesis on underwater control systems is written with the designer in mind, assuming that the reader has some knowledge of control theory. It can be used as a text for undergraduate students and engineers. To help readers better understand the system they will be working with, the thesis is organised in a stepwise way. The reader will gain basic knowledge about underwater operations, equipment and control systems. Then the reader will be able to follow the steps to develop a required control system for an underwater equipment by first understanding the characteristics of the design problem, customer requirement, functional requirement, and possible solution, and then to present a mathematical model of the control problem. Having developed the concept, the thesis guides the reader to develop evaluation criteria and different ways to make the decision. The thesis gives an overview of how to achieve a successful design rather than giving the techniques for detailed control system design. Chapter 1 describes underwater operations and systems. Chapter 2 discusses issues of underwater control systems and control methods. Chapter 3 deals with design method and control systems theory, focusing on human-centered control. Chapter 4 discusses methods used to evaluate and rank products, and chapter 5 applies the methods to an example. 113 refs., 115 figs., 80 tabs.

  18. A New Physical Protection System Design and Evaluation Process

    Energy Technology Data Exchange (ETDEWEB)

    Lim, Heoksoon; Kim, Myungsu; Bae, Yeongkyoung; Na, Janghwan [KHNP-CRI, Daejeon (Korea, Republic of)

    2014-10-15

    International Atomic Energy Agency(IAEA) had established security-related department and has been strengthening security measures against possible sabotage. IAEA enforces the recommendations for the physical protection of NPPs in the INFCIRC/ 225/Rev.5 to the member states and U.S. NRC also enforces the similar requirements in 10 CFR 73.55. Thus, in order to let Korean NPPs meet the new requirements in INFCIRC/225/Rev.5 or U.S. NRC requirements, Korea nuclear licensee should develop or establish appropriate physical protection system (PPS) design methods for the physical protection of the operating NPPs and new NPPs. KHNP is doing the project of 'Development of APR1400 Physical Protection System Design (2012- 2015, KHNP/KAERI /KEPCO E-C)'. This paper describes overview of a physical protection system (PPS) design and evaluation for an advanced nuclear power plant. It found that a new physical protection system (PPS)design and evaluation. KHNP is doing the project of Physical Protection System design according to U.S. NRC requirements and IAEA requirements in INFCIRC /225 /Rev.5 and will complete by 7.31, 2015 for development of APR1400 Physical Protection System. After completing this project, the results of project are expected to apply new NPPs.

  19. Ergonomic design and evaluation of a diagnostic ultrasound transducer holder.

    Science.gov (United States)

    Ghasemi, Mohamad Sadegh; Hosseinzadeh, Payam; Zamani, Farhad; Ahmadpoor, Hossein; Dehghan, Naser

    2017-12-01

    Work-related musculoskeletal disorders (WMSDs) are injuries and disorders that affect the body's movement and musculoskeletal system. Awkward postures represent one of the major ergonomic risk factors that cause WMSDs among sonographers while working with an ultrasound transducer. This study aimed to design and evaluate a new holder for the ultrasound transducer. In the first phase a new holder was designed for the transducer, considering design principles. Evaluation of the new holder was then carried out by electrogoniometry and a locally perceived discomfort (LPD) scale. The application of design principles to the new holder resulted in an improvement of wrist posture and comfort. Wrist angles in extension, flexion, radial deviation and ulnar deviation were lower with utilization of the new holder. The severity of discomfort based on the LPD method in the two modes of work with and without the new holder was reported with values of 1.3 and 1.8, respectively (p ergonomics design principles was effective in minimizing wrist deviation and increasing comfort while working with the new holder.

  20. Design and Evaluation of Human System Interfaces (HSIs)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-07-01

    In the safe operation of nuclear power plants and other complex process industries the performance of the control room crews plays an important role. In this respect a well-functioning and well-designed Human-System Interface (HSI) is crucial for safe and efficient operation of the plant. It is therefore essential that the design, development and evaluation of both control rooms and HSI-solutions are conducted in a well-structured way, applying sound human factors principles and guidelines in all phases of the HSI development process. Many nuclear power plants around the world are currently facing major modernisation of their control rooms. In this process computerised, screen-based HSIs replace old conventional operator interfaces. In new control rooms, both in the nuclear field and in other process industries, fully digital, screen-based control rooms are becoming the standard. It is therefore of particular importance to address the design and evaluation of screen-based HSIs in a systematic and consistent way in order to arrive at solutions which take proper advantage of the possibilities for improving operator support through the use of digital, screen-based HSIs, at the same time avoiding pitfalls and problems in the use of this technology. The Halden Reactor Project, in cooperation with the OECD Nuclear Energy Agency, organised an International Summer School on ''Design and Evaluation of Human-System Interfaces (HSIs)'' in Halden, Norway in the period August 25th - 29th, 2003. The Summer School addressed the different steps in design, development and evaluation of HSIs, and the human factors principles, standards and guidelines which should be followed in this process. The lectures comprised both theoretical background, as well as examples of good and bad HSI design, thereby providing practical advice in design and evaluation of operator interfaces and control room solutions to the participants in the Summer School. This CD contains the

  1. Design and Evaluation of Human System Interfaces (HSIs)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-07-01

    In the safe operation of nuclear power plants and other complex process industries the performance of the control room crews plays an important role. In this respect a well-functioning and well-designed Human-System Interface (HSI) is crucial for safe and efficient operation of the plant. It is therefore essential that the design, development and evaluation of both control rooms and HSI-solutions are conducted in a well-structured way, applying sound human factors principles and guidelines in all phases of the HSI development process. Many nuclear power plants around the world are currently facing major modernisation of their control rooms. In this process computerised, screen-based HSIs replace old conventional operator interfaces. In new control rooms, both in the nuclear field and in other process industries, fully digital, screen-based control rooms are becoming the standard. It is therefore of particular importance to address the design and evaluation of screen-based HSIs in a systematic and consistent way in order to arrive at solutions which take proper advantage of the possibilities for improving operator support through the use of digital, screen-based HSIs, at the same time avoiding pitfalls and problems in the use of this technology. The Halden Reactor Project, in cooperation with the OECD Nuclear Energy Agency, organised an International Summer School on ''Design and Evaluation of Human-System Interfaces (HSIs)'' in Halden, Norway in the period August 25th - 29th, 2003. The Summer School addressed the different steps in design, development and evaluation of HSIs, and the human factors principles, standards and guidelines which should be followed in this process. The lectures comprised both theoretical background, as well as examples of good and bad HSI design, thereby providing practical advice in design and evaluation of operator interfaces and control room solutions to the participants in the Summer School. This CD contains the Proceedings of the

  2. Design and Evaluation of Human System Interfaces (HSIs)

    International Nuclear Information System (INIS)

    2003-01-01

    In the safe operation of nuclear power plants and other complex process industries the performance of the control room crews plays an important role. In this respect a well-functioning and well-designed Human-System Interface (HSI) is crucial for safe and efficient operation of the plant. It is therefore essential that the design, development and evaluation of both control rooms and HSI-solutions are conducted in a well-structured way, applying sound human factors principles and guidelines in all phases of the HSI development process. Many nuclear power plants around the world are currently facing major modernisation of their control rooms. In this process computerised, screen-based HSIs replace old conventional operator interfaces. In new control rooms, both in the nuclear field and in other process industries, fully digital, screen-based control rooms are becoming the standard. It is therefore of particular importance to address the design and evaluation of screen-based HSIs in a systematic and consistent way in order to arrive at solutions which take proper advantage of the possibilities for improving operator support through the use of digital, screen-based HSIs, at the same time avoiding pitfalls and problems in the use of this technology. The Halden Reactor Project, in cooperation with the OECD Nuclear Energy Agency, organised an International Summer School on ''Design and Evaluation of Human-System Interfaces (HSIs)'' in Halden, Norway in the period August 25th - 29th, 2003. The Summer School addressed the different steps in design, development and evaluation of HSIs, and the human factors principles, standards and guidelines which should be followed in this process. The lectures comprised both theoretical background, as well as examples of good and bad HSI design, thereby providing practical advice in design and evaluation of operator interfaces and control room solutions to the participants in the Summer School. This CD contains the Proceedings of the

  3. Designing and Evaluating Conative Game-Based Learning Scenarios

    DEFF Research Database (Denmark)

    Schønau-Fog, Henrik

    2014-01-01

    It is an essential prerequisite to design for motivation in game-based learning applications, tools and activities. However, how is it possible to design and evaluate motivational game-based learning scenarios in a systematic process-oriented manner based on conation and player engagement? While...... of ‘continuation desire’ such as interfacing with the scenario, exploration and socialising. This paper aims to combine the concepts of Player Engagement, Conation and Continuation Desire by focusing on the conative aspects which are the essential drivers for the desire to continue any learning activity......-based learning scenarios....

  4. Design synthesis and biological evaluation of 2-methylphenyl semicarbazone derivatives

    Directory of Open Access Journals (Sweden)

    Manmohan Singhal

    2011-03-01

    Full Text Available We have used pharmacophore hybridization technique of drug design and designed a pharmacophore model 2-methylphenylsemicarbazone which is having hydrogen acceptor site, hydrogen donor site, lipophilic site etc using ligandscout-2.02 software. A series of 2-methylphenyl-semicarbazone was synthesized and evaluated for their antipyretic activity using boiled cow milk induced pyrexia in rabbits. Compound 11 was the most active compound. The possible metabolites of some selected synthesized chalconesemicarbazones were predicted by computational method using Pallas version-3.1 ADME-Tox prediction software. The major pathway of metabolism was found to be p-hydroxylation and amide hydrolysis.

  5. Societal risk approach to safeguards design and evaluation

    International Nuclear Information System (INIS)

    Murphey, W.M.; Sherr, T.S.; Bennett, C.A.

    1975-01-01

    A comprehensive rationale for safeguards design and evaluation, and a framework for continuing systematic assessment of the system's effectiveness and efficient allocation of available safeguards resources for balanced protection, were developed. The societal risk approach employed considers the likelihood of successful destructive acts involving nuclear materials or facilities and the magnitude of the effects on society. The safeguards problem is described in terms of events affecting societal risk and adversary actions. Structure of the safeguards system and the evaluation of its adequacy are discussed. Adversary characteristics are also discussed

  6. An Evaluation of Alternative Designs for a Grid Information Service

    Science.gov (United States)

    Smith, Warren; Waheed, Abdul; Meyers, David; Yan, Jerry; Kwak, Dochan (Technical Monitor)

    2001-01-01

    The Globus information service wasn't working well. There were many updates of data from Globus daemons which saturated the single server and users couldn't retrieve information. We created a second server for NASA and Alliance. Things were great on that server, but a bit slow on the other server. We needed to know exactly how the information service was being used. What were the best servers and configurations? This viewgraph presentation gives an overview of the evaluation of alternative designs for a Grid Information Service. Details are given on the workload characterization, methodology used, and the performance evaluation.

  7. Evaluation of Market Design Agents: The Mertacor Perspective

    Science.gov (United States)

    Stavrogiannis, Lampros C.; Mitkas, Pericles A.

    The annual Trading Agent Competition for Market Design, CAT, provides a testbed to study the mechanisms that modern stock exchanges use in their effort to attract potential traders while maximizing their profit. This paper presents an evaluation of the agents that participated in the 2008 competition. The evaluation is based on the analysis of the CAT finals as well as on the results obtained from post-tournament experiments. We present Mertacor, our entrant for 2008, and compare it with the other available agents. In addition, we introduce a simple yet effective way of computing the global competitive equilibrium that Mertacor utilizes and discuss its importance for the game.

  8. Ergonomic requirements to control room design - evaluation method

    International Nuclear Information System (INIS)

    Hinz, W.

    1985-01-01

    The method of evaluation introduced is the result of work carried out by the sub-committee 'Control Room Design' of the Engineering Standards Committee in DIN Standards, Ergonomy. This committee compiles standards for the design of control rooms (instrumentation and control) for the monitoring and operation of process engineering cycles. With the agreement of the committee - whom we wish to take the opportunity of thanking at this point for their constructive collaboration - a planned partial standard will be introduced thematically in the following, in order that knowledge gained from the discussion can be included in further work on the subject. The matter in question is a procedure for the qualitative evaluation of the duties to be performed under the control of operators in order that an assessment can be made of existing control concepts or such concepts as are to be found in the draft phase. (orig./GL) [de

  9. Statistical evaluation of design-error related accidents

    International Nuclear Information System (INIS)

    Ott, K.O.; Marchaterre, J.F.

    1980-01-01

    In a recently published paper (Campbell and Ott, 1979), a general methodology was proposed for the statistical evaluation of design-error related accidents. The evaluation aims at an estimate of the combined residual frequency of yet unknown types of accidents lurking in a certain technological system. Here, the original methodology is extended, as to apply to a variety of systems that evolves during the development of large-scale technologies. A special categorization of incidents and accidents is introduced to define the events that should be jointly analyzed. The resulting formalism is applied to the development of the nuclear power reactor technology, considering serious accidents that involve in the accident-progression a particular design inadequacy

  10. New Discrete Fibonacci Charge Pump Design, Evaluation and Measurement

    Directory of Open Access Journals (Sweden)

    Matoušek David

    2017-06-01

    Full Text Available This paper focuses on the practical aspects of the realisation of Dickson and Fibonacci charge pumps. Standard Dickson charge pump circuit solution and new Fibonacci charge pump implementation are compared. Both charge pumps were designed and then evaluated by LTspice XVII simulations and realised in a discrete form on printed circuit board (PCB. Finally, the key parameters as the output voltage, efficiency, rise time, variable power supply and clock frequency effects were measured.

  11. New Discrete Fibonacci Charge Pump Design, Evaluation and Measurement

    Science.gov (United States)

    Matoušek, David; Hospodka, Jiří; Šubrt, Ondřej

    2017-06-01

    This paper focuses on the practical aspects of the realisation of Dickson and Fibonacci charge pumps. Standard Dickson charge pump circuit solution and new Fibonacci charge pump implementation are compared. Both charge pumps were designed and then evaluated by LTspice XVII simulations and realised in a discrete form on printed circuit board (PCB). Finally, the key parameters as the output voltage, efficiency, rise time, variable power supply and clock frequency effects were measured.

  12. The conceptual design and economic evaluation of utility scale SMES

    International Nuclear Information System (INIS)

    Masuda, M.

    1986-01-01

    The paper reports the result of current Japanese activities in designing and evaluating the economic feasibility of utility Superconducting Magnetic Energy Storage (SMES). The 5 GWh/1 GW is proposed as a relevant unit of SMES in the year 2000. More than 20 companies, several universities and two national laboratories joined in a task force to study this technology. After three year's assessment, the conclusion on utility scale SMES is that no unresolvable technologies have been found and commercialization potential exists

  13. Web-Based Museum Trails on PDAs for University-Level Design Students: Design and Evaluation

    Science.gov (United States)

    Reynolds, R.; Walker, K.; Speight, C.

    2010-01-01

    This paper describes the development and evaluation of web-based museum trails for university-level design students to access on handheld devices in the Victoria and Albert Museum (V&A) in London. The trails offered students a range of ways of exploring the museum environment and collections, some encouraging students to interpret objects and…

  14. Participatory ergonomics for psychological factors evaluation in work system design.

    Science.gov (United States)

    Wang, Lingyan; Lau, Henry Y K

    2012-01-01

    It is a well recognized understanding that workers whose voice needs to be heard should be actively encouraged as full participants and involved in the early design stages of new ergonomic work system which encompass the development and implementation of new tools, workplaces, technologies or organizations. This paper presents a novel participatory strategy to evaluate three key psychological factors which are respectively mental fatigue, spiritual stress, and emotional satisfaction in work system design based on a modified version of Participatory Ergonomics (PE). In specific, it integrates a PE technique with a formulation view by combining the parallel development of PE strategies, frameworks and functions throughout the coverage of the entire work system design process, so as to bridge the gap between qualitative and quantitative analysis of psychological factors which can cause adverse or advantageous effects on worker's physiological and behavioral performance.

  15. Evaluating public awareness of new currency design features

    Science.gov (United States)

    DiNunzio, Lisa; Church, Sara E.

    2002-04-01

    One of the goals of the 1996 series design was to integrate highly recognizable features that enable the general public to more easily distinguish counterfeit from genuine notes, thereby reducing the chance of counterfeit notes being passed. The purpose of this study is to evaluate how knowledgeable the public is concerning the new currency, to identify the channels through which the public learns about new currency design, and to assess the usefulness of the new currency's authentication features. Also, the study will serve as a baseline measurement for future design studies and in comparative analysis with other countries. The results of the qualitative research will be described in the following sections of this paper. The quantitative research is scheduled to begin in February 2002, at the same time as the Netherlands' opinion poll of the Euro and NLG-notes in an effort to compare results.

  16. Evaluation of seismic criteria used in design of INEL facilities

    International Nuclear Information System (INIS)

    Young, G.A.

    1977-01-01

    This report provides the results of an independent evaluation of seismic studies that were made to establish the seismic acceleration levels and the response spectra used in the design of vital facilities at Idaho National Engineering Laboratory. A comparison of the procedures used to define the seismic acceleration values and response spectra at INEL with the requirements of the Nuclear Regulatory Commission showed that additional geologic studies would probably be required in order to fulfill NRC regulations. Recommendations are made on justifiable changes in the acceleration values and response spectra used at INEL. The geologic, geophysical, and seismological studies needed to provide a better understanding of the tectonic processes in the Snake River plains and the surrounding region are identified. Both potential and historical acceleration values are evaluated on a probability basis to permit a risk assessment approach to the design of new facilities and facility modifications. Studies conducted to develop seismic criteria for the design of the Loss of Fluid Test reactor and the New Waste Calcining Facility were selected as typical examples of criteria development previously used in the design of INEL facilities

  17. Design, Construction and Evaluation of a Dry Solar Sterilizer

    International Nuclear Information System (INIS)

    Hernández Fereira, Arcelio A.

    2017-01-01

    The objective of the work was the search of an alternative for sterilization using solar energy. For such purposes, a dry solar sterilizer of 4276 cm3 capacity was designed, constructed and evaluated. Potential users would be rural medical posts in areas without electricity, health posts in military units under field conditions, and experimental microbiology stations. The evaluation included the determination of the energy efficiency of the sterilizer, the economic evaluation against other variants and the biological safety assessment. The developed equipment reached the sterilization temperature for levels of the direct component of the solar radiation higher than 300 W/m2 in 14 minutes, corresponding to an average heating rate of 13 0C/minute, higher than that of an electric furnace. Its energy efficiency with direct solar radiation of 310.5 W/m2 was 53.79%. The equipment is of easy construction, simple operation and very low cost. (author)

  18. Large scale solar district heating. Evaluation, modelling and designing

    Energy Technology Data Exchange (ETDEWEB)

    Heller, A.

    2000-07-01

    The main objective of the research was to evaluate large-scale solar heating connected to district heating (CSDHP), to build up a simulation tool and to demonstrate the application of the tool for design studies and on a local energy planning case. The evaluation of the central solar heating technology is based on measurements on the case plant in Marstal, Denmark, and on published and unpublished data for other, mainly Danish, CSDHP plants. Evaluations on the thermal, economical and environmental performances are reported, based on the experiences from the last decade. The measurements from the Marstal case are analysed, experiences extracted and minor improvements to the plant design proposed. For the detailed designing and energy planning of CSDHPs, a computer simulation model is developed and validated on the measurements from the Marstal case. The final model is then generalised to a 'generic' model for CSDHPs in general. The meteorological reference data, Danish Reference Year, is applied to find the mean performance for the plant designs. To find the expectable variety of the thermal performance of such plants, a method is proposed where data from a year with poor solar irradiation and a year with strong solar irradiation are applied. Equipped with a simulation tool design studies are carried out spreading from parameter analysis over energy planning for a new settlement to a proposal for the combination of plane solar collectors with high performance solar collectors, exemplified by a trough solar collector. The methodology of utilising computer simulation proved to be a cheap and relevant tool in the design of future solar heating plants. The thesis also exposed the demand for developing computer models for the more advanced solar collector designs and especially for the control operation of CSHPs. In the final chapter the CSHP technology is put into perspective with respect to other possible technologies to find the relevance of the application

  19. Engineering design evaluation of Atlas tile-calorimeter

    International Nuclear Information System (INIS)

    Hill, N.; Guarino, V.; Proudfoot, J.; Stanek, R.; Price, L.; Petereit, E.

    1994-01-01

    In an effort to familiarize themselves with the work that has been done to date on the design of the Tile Cal hadron calorimeter for Atlas, the authors have undertaken a thorough examination of the current designs. They concentrated on the work that has been done by the IHEP Group at Protvino, and in particular the work presented at the last Atlas Week. They constructed six different finite element models as they have learned more about the system. These models were meant to be rough models only and do not represent actual construction in all cases. In some cases, shortcuts were taken in an attempt to set boundary conditions and to reduce the size of the problem to accommodate software limitations, while still providing enough information to further the understanding of the design. After reviewing the analysis and thinking about the construction, the authors have some suggested modifications, which are presented in this paper. It is clear that the work done at both CERN and Protvino has been impressive and thorough. The authors have tried to evaluate and understand both the CERN baseline design and the suggested design option from Protvino

  20. Procedure for seismic evaluation and design of small bore piping

    International Nuclear Information System (INIS)

    Bilanin, W.; Sills, S.

    1991-01-01

    Simplified methods for the seismic design of small bore piping in nuclear power plants have teen used for many years. Various number of designers have developed unique methods to treat the large number of class 2 and 3 small bore piping systems. This practice has led to a proliferation of methods which are not standardized in the industry. These methods are generally based on enveloping the results of rigorous dynamic or conservative static analysis and result in an excessive number of supports and unrealistically high support loadings. Experience and test data have become available which warranted taking another look at the present methods for analysis of small bore piping. A recently completed Electric Power Research Institute and NCIG (a utility group) activity developed a new procedure for the seismic design and evaluation of small bore piping which provides significant safety and cost benefits. The procedure streamlines the approach to inertial stresses, which is the main feature that achieves the new benefits. Criteria in the procedure for seismic anchor movement and support design are based analysis and focus the designer on credible failure mechanisms. A walkdown of the as-constructed piping system to identify and eliminate undesirable piping features such as adverse spatial interaction is required

  1. Design evaluation on sodium piping system and comparison of the design codes

    International Nuclear Information System (INIS)

    Lee, Dong Won; Jeong, Ji Young; Lee, Yong Bum; Lee, Hyeong Yeon

    2015-01-01

    A large-scale sodium test loop of STELLA-1 (Sodium integral effect test loop for safety simulation and assessment) with two main piping systems has been installed at KAERI. In this study, design evaluations on the main sodium piping systems in STELLA-1 have been conducted according to the DBR (design by rule) codes of the ASME B31.1 and RCC-MRx RB-3600. In addition, design evaluations according to the DBA (design by analysis) code of the ASME Section III Subsection NB-3200 have been conducted. The evaluation results for the present piping systems showed that results from the DBR codes were more conservative than those from the DBA code, and among the DBR codes, the non-nuclear code of the ASME B31.1 was more conservative than the French nuclear DBR code of the RCC-MRx RB-3600. The conservatism on the DBR codes of the ASME B31.1 and RCC-MRx RB-3600 was quantified based on the present sodium piping analyses.

  2. Design evaluation on sodium piping system and comparison of the design codes

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Dong Won; Jeong, Ji Young; Lee, Yong Bum; Lee, Hyeong Yeon [KAERI, Daejeon (Korea, Republic of)

    2015-03-15

    A large-scale sodium test loop of STELLA-1 (Sodium integral effect test loop for safety simulation and assessment) with two main piping systems has been installed at KAERI. In this study, design evaluations on the main sodium piping systems in STELLA-1 have been conducted according to the DBR (design by rule) codes of the ASME B31.1 and RCC-MRx RB-3600. In addition, design evaluations according to the DBA (design by analysis) code of the ASME Section III Subsection NB-3200 have been conducted. The evaluation results for the present piping systems showed that results from the DBR codes were more conservative than those from the DBA code, and among the DBR codes, the non-nuclear code of the ASME B31.1 was more conservative than the French nuclear DBR code of the RCC-MRx RB-3600. The conservatism on the DBR codes of the ASME B31.1 and RCC-MRx RB-3600 was quantified based on the present sodium piping analyses.

  3. Rapid Structural Design Change Evaluation with AN Experiment Based FEM

    Science.gov (United States)

    Chu, C.-H.; Trethewey, M. W.

    1998-04-01

    The work in this paper proposes a dynamic structural design model that can be developed in a rapid fashion. The approach endeavours to produce a simplified FEM developed in conjunction with an experimental modal database. The FEM is formulated directly from the geometry and connectivity used in an experimental modal test using beam/frame elements. The model sacrifices fine detail for a rapid development time. The FEM is updated at the element level so the dynamic response replicates the experimental results closely. The physical attributes of the model are retained, making it well suited to evaluate the effect of potential design changes. The capabilities are evaluated in a series of computational and laboratory tests. First, a study is performed with a simulated cantilever beam with a variable mass and stiffness distribution. The modal characteristics serve as the updating target with random noise added to simulate experimental uncertainty. A uniformly distributed FEM is developed and updated. The results show excellent results, all natural frequencies are within 0·001% with MAC values above 0·99. Next, the method is applied to predict the dynamic changes of a hardware portal frame structure for a radical design change. Natural frequency predictions from the original FEM differ by as much as almost 18% with reasonable MAC values. The results predicted from the updated model produce excellent results when compared to the actual hardware changes, the first five modal natural frequency difference is around 5% and the corresponding mode shapes producing MAC values above 0·98.

  4. Ranitidine Loaded Biopolymer Floats: Designing, Characterization, and Evaluation

    Directory of Open Access Journals (Sweden)

    Abdul Karim

    2017-01-01

    Full Text Available The float formulation is a strategy to improve the bioavailability of drugs by gastroretentive drug delivery system (GRDDS. A drug delivery model based on swellable and reswellable low density biopolymers has been designed to evaluate its drug release profile using ranitidine (RNT as a model drug and formulations have been prepared utilizing 32 factorial designs. The drug release (DR data has been subjected to various kinetic models to investigate the DR mechanism. A reduction in rate has been observed by expanding the amounts of PSG and LSG parts, while an expansion has been noted by increasing the concentration of tragacanth (TG and citric acid (CA with an increment in floating time. The stearic acid (SA has been used to decrease the lag time because a decrease in density of system was observed. The kinetic analysis showed that the optimized formulation (S4F3 followed zero-order kinetics and power law was found to be best fitted due to its minimum lag time and maximum floating ability. The resemblance of observed and predicted values indicated the validity of derived equations for evaluating the effect of independent variables while kinetic study demonstrated that the applied models are feasible for evaluating and developing float for RNT.

  5. Designing and Evaluating Interventions to Halt the Transmission of Tuberculosis.

    Science.gov (United States)

    Dowdy, David W; Grant, Alison D; Dheda, Keertan; Nardell, Edward; Fielding, Katherine; Moore, David A J

    2017-11-03

    To reduce the incidence of tuberculosis, it is insufficient to simply understand the dynamics of tuberculosis transmission. Rather, we must design and rigorously evaluate interventions to halt transmission, prioritizing those interventions most likely to achieve population-level impact. Synergy in reducing tuberculosis transmission may be attainable by combining interventions that shrink the reservoir of latent Mycobacterium tuberculosis infection (preventive therapy), shorten the time between disease onset and treatment initiation (case finding and diagnosis), and prevent transmission in key settings, such as the built environment (infection control). In evaluating efficacy and estimating population-level impact, cluster-randomized trials and mechanistic models play particularly prominent roles. Historical and contemporary evidence suggests that effective public health interventions can halt tuberculosis transmission, but an evidence-based approach based on knowledge of local epidemiology is necessary for success. We provide a roadmap for designing, evaluating, and modeling interventions to interrupt the process of transmission that fuels a diverse array of tuberculosis epidemics worldwide. © The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America.

  6. Evaluation of design flood estimates with respect to sample size

    Science.gov (United States)

    Kobierska, Florian; Engeland, Kolbjorn

    2016-04-01

    Estimation of design floods forms the basis for hazard management related to flood risk and is a legal obligation when building infrastructure such as dams, bridges and roads close to water bodies. Flood inundation maps used for land use planning are also produced based on design flood estimates. In Norway, the current guidelines for design flood estimates give recommendations on which data, probability distribution, and method to use dependent on length of the local record. If less than 30 years of local data is available, an index flood approach is recommended where the local observations are used for estimating the index flood and regional data are used for estimating the growth curve. For 30-50 years of data, a 2 parameter distribution is recommended, and for more than 50 years of data, a 3 parameter distribution should be used. Many countries have national guidelines for flood frequency estimation, and recommended distributions include the log Pearson II, generalized logistic and generalized extreme value distributions. For estimating distribution parameters, ordinary and linear moments, maximum likelihood and Bayesian methods are used. The aim of this study is to r-evaluate the guidelines for local flood frequency estimation. In particular, we wanted to answer the following questions: (i) Which distribution gives the best fit to the data? (ii) Which estimation method provides the best fit to the data? (iii) Does the answer to (i) and (ii) depend on local data availability? To answer these questions we set up a test bench for local flood frequency analysis using data based cross-validation methods. The criteria were based on indices describing stability and reliability of design flood estimates. Stability is used as a criterion since design flood estimates should not excessively depend on the data sample. The reliability indices describe to which degree design flood predictions can be trusted.

  7. CONTRIBUTIONS TO EVALUATE DESIGN INVESTMENT IN PORTUGUESE ORANGE FROM SILVES

    Directory of Open Access Journals (Sweden)

    Filipa Pias

    2016-12-01

    Full Text Available Food reminds us every day that we are a part of nature and with our daily choices it is we who preserve or not biodiversity and species. It is we who promote or not the production of more health and fresh food. In an increasingly informed society about the benefits of having a balanced diet, meals started to be seen as tasting flavours and aromas, a moment of well-being, where the origin, production and method of preparation of agricultural products play a leading role. Because the market has changed, it is no longer anonymous it became personalized and essentially motivated by what you can enjoy, which implies a willingness to participate and build its own experience. In general, the companies believe that design collaboration is an advantage but if they do not have means of measuring design’s cost/benefit, it will not be easy to understand design as an investment that brings value to business. The purpose of this research is to draw the attention for the importance of design management, by evaluating the return of design’s investment in the Portuguese agro-food industry and by developing a model that allows them to assess the return on investment in design.

  8. Design Optimization and Evaluation of Different Wind Generator Systems

    DEFF Research Database (Denmark)

    Chen, Zhe; Li, Hui

    2008-01-01

    . In this paper, seven variable speed constant frequency (VSCF) wind generator systems are investigated, namely permanent magnet synchronous generators with the direct-driven (PMSG_DD), the single-stage gearbox (PMSG_1G) and three-stage gearbox (PMSG_3G) concepts, doubly fed induction generators with the three......With rapid development of wind power technologies and significant growth of wind power capacity installed worldwide, various wind generator systems have been developed and built. The objective of this paper is to evaluate various wind generator systems by optimization designs and comparisons......-stage gearbox (DFIG_3G) and with the single-stage gearbox (DFIG_1G), the electricity excited synchronous generator with the direct-driven (EESG_DD), and the VSCF squirrel cage induction generator with the three-stage gearbox (SCIG_3G). Firstly, the design models of wind turbines, three/single stage gearbox...

  9. Evaluation of the DRAGON code for VHTR design analysis.

    Energy Technology Data Exchange (ETDEWEB)

    Taiwo, T. A.; Kim, T. K.; Nuclear Engineering Division

    2006-01-12

    This letter report summarizes three activities that were undertaken in FY 2005 to gather information on the DRAGON code and to perform limited evaluations of the code performance when used in the analysis of the Very High Temperature Reactor (VHTR) designs. These activities include: (1) Use of the code to model the fuel elements of the helium-cooled and liquid-salt-cooled VHTR designs. Results were compared to those from another deterministic lattice code (WIMS8) and a Monte Carlo code (MCNP). (2) The preliminary assessment of the nuclear data library currently used with the code and libraries that have been provided by the IAEA WIMS-D4 Library Update Project (WLUP). (3) DRAGON workshop held to discuss the code capabilities for modeling the VHTR.

  10. Safety design and evaluation policy for future FBRs in Japan

    International Nuclear Information System (INIS)

    Aizawa, Kiyoto

    1991-01-01

    The safety policy for fast breeder reactors (FBRs) has gradually matured in accordance with the development of FBRs. The safety assessment of the Japanese prototype FBR, Monju during the licensing process accelerated the maturity and the integration of knowledge and databases. Results are expected to be reflected in the establishment of the safety design and evaluation policy for FBRs. Although the methodologies and safety policies developed for LWRs are applicable in principle to future FBRs, it is neither rational nor realistic to treat safety only with these policies. It is recommended that one should develop the methodologies and safety policies starting from understanding of the inherent safety characteristics of FBR's through safety research, plant operating experience and design work. In the last few years, some technical committees were organized in Japan and have discussed key safety issues which are specific to FBRs in order to provide preparatory reports and to establish safety standards and guidelines for future commercial FBRs. (author)

  11. Evaluation of the DRAGON code for VHTR design analysis

    International Nuclear Information System (INIS)

    Taiwo, T. A.; Kim, T. K.; Nuclear Engineering Division

    2006-01-01

    This letter report summarizes three activities that were undertaken in FY 2005 to gather information on the DRAGON code and to perform limited evaluations of the code performance when used in the analysis of the Very High Temperature Reactor (VHTR) designs. These activities include: (1) Use of the code to model the fuel elements of the helium-cooled and liquid-salt-cooled VHTR designs. Results were compared to those from another deterministic lattice code (WIMS8) and a Monte Carlo code (MCNP). (2) The preliminary assessment of the nuclear data library currently used with the code and libraries that have been provided by the IAEA WIMS-D4 Library Update Project (WLUP). (3) DRAGON workshop held to discuss the code capabilities for modeling the VHTR

  12. Process Design and Evaluation for Chemicals Based on Renewable Resources

    DEFF Research Database (Denmark)

    Fu, Wenjing

    . In addition, another characteristic of chemicals based on renewable feedstocks is that many alternative technologies and possible routes exist, resulting in many possible process flowsheets. The challenge for process engineers is then to choose between possible process routes and alternative technologies...... development of chemicals based on renewable feedstocks. As an example, this thesis especially focuses on applying the methodology in process design and evaluation of the synthesis of 5-hydroxymethylfurfural (HMF) from the renewable feedstock glucose/fructose. The selected example is part of the chemoenzymatic......One of the key steps in process design is choosing between alternative technologies, especially for processes producing bulk and commodity chemicals. Recently, driven by the increasing oil prices and diminishing reserves, the production of bulk and commodity chemicals from renewable feedstocks has...

  13. Evaluating comfort with varying temperatures: a graphic design tool

    Energy Technology Data Exchange (ETDEWEB)

    Evans, J.M. [Research Centre Habitat and Energy, Faculty of Architecture, Design and Urbanism, University of Buenos Aires, Ciudad Universitaria (Argentina)

    2002-07-01

    This paper considers the need to define comfort of indoor and outdoor spaces in relation to the daily variations of temperature. A graphical tool is presented, which indicates the daily swings of temperature, shown as a single point on a graph representing the average temperature and the maximum temperature swing. This point can be compared with the comfort zones for different activity levels, such as sedentary activity, sleeping, indoor and outdoor circulation according to the design proposals for different spaces. The graph allows the representation of climatic variables, the definition of comfort zones, the selection of bio climatic design resources and the evaluation of indoor temperatures, measured in actual buildings or obtained from computer simulations. The development of the graph is explained and examples given with special emphasis on the use of thermal mass. (author)

  14. Using GREENSCOPE Indicators for Sustainable Computer-Aided Process Evaluation and Design

    Science.gov (United States)

    Manufacturing sustainability can be increased by educating those who design, construct, and operate facilities, and by using appropriate tools for process evaluation and design. The U.S. Environmental Protection Agency's GREENSCOPE methodology and tool, for evaluation and design ...

  15. Evaluation of Mass Housing at the Pre-Design Stage

    Directory of Open Access Journals (Sweden)

    Kozan UZUNOĞLU

    2014-09-01

    Full Text Available Throughout history, housing has been a central problem in the lives of human beings. Housing, which includes shelter for family and functional volumes that meet social needs, used to be built specifically for the family. The concept of “Mass Housing” entered the field of architecture as a result of the industrial revolution, when lavish Renaissance housing gradually turned into housing for workers. Today, the demand for housing cannot keep up with fast-growing populations. Besides the quantitative problems of housing production, there is the ever- growing problem of quality, the solution to which lies with designer architects. On this issue of quality, Post Occupation Evaluation (POE studies, conducted to provide data for upcoming designs, and certificate evaluations like LEED and BREEAM, aimed at measuring energy performance effectiveness of new buildings, mostly involve measurements of usage of the building envelope, environmental relations, facilities and usage of natural resources. None prioritize the form and function issues of spatial usage in architectural designs. This study proposes a method that enables spatial and functional measurement and assessment at the project stage. The suggested spatial performance measurement–assessment system has three stages. In the first stage, the standards and usage criteria to be used as reference in the assessment are defined. The second stage suggests using the SAR analysis approach, and the third stage is about conducting “Spatial Performance Assessment”. Here, the common denominator of “User System” and “Building System”, which shares characteristic design criteria “Form, Function,Construction” is established and by this way, testing and assessing the subject of study becomes possible. With these assessments, by providing digitalization of spatial performance with proportional values, it is believed that a database for the provision of statistical information may be established.

  16. Pharmacology Goes Concept-Based: Course Design, Implementation, and Evaluation.

    Science.gov (United States)

    Lanz, Amelia; Davis, Rebecca G

    Although concept-based curricula are frequently discussed in the nursing education literature, little information exists to guide the development of a concept-based pharmacology course. Traditionally, nursing pharmacology courses are taught with an emphasis on drug class where a prototype drug serves as an exemplar. When transitioning pharmacology to a concept-based course, special considerations are in order. How can educators successfully integrate essential pharmacological content into a curriculum structured around nursing concepts? This article presents one approach to the design and implementation of a concept-based undergraduate pharmacology course. Planning methods, supportive teaching strategies, and course evaluation procedures are discussed.

  17. Preliminary shielding design evaluation for reactor assembly of SMART

    International Nuclear Information System (INIS)

    Kim, Kyo Youn; Kang, Chang M.; Kim, Ha Yong; Zee, Sung Quun; Chang, Moon Hee

    1999-03-01

    This report describes a preliminary evaluations of SMART shielding design near the reactor core by using the DORT two-dimensional discrete ordinates transport code. The results indicate that maximum neutron fluence at the bottom of reactor vessel is 1.64x10 17 n/cm 2 and that on the radial surface of reactor vessel is 6.71x10 16 n/cm 2 . These results meet the requirement, 1.0x10 20 n/cm 2 , in 10 CFR 50.61 and the integrity of SMART reactor vessel is confirmed during the lifetime of reactor. (Author). 20 refs., 11 tabs., 8 figs

  18. Interfacial Micromechanics in Fibrous Composites: Design, Evaluation, and Models

    Science.gov (United States)

    Lei, Zhenkun; Li, Xuan; Qin, Fuyong; Qiu, Wei

    2014-01-01

    Recent advances of interfacial micromechanics in fiber reinforced composites using micro-Raman spectroscopy are given. The faced mechanical problems for interface design in fibrous composites are elaborated from three optimization ways: material, interface, and computation. Some reasons are depicted that the interfacial evaluation methods are difficult to guarantee the integrity, repeatability, and consistency. Micro-Raman study on the fiber interface failure behavior and the main interface mechanical problems in fibrous composites are summarized, including interfacial stress transfer, strength criterion of interface debonding and failure, fiber bridging, frictional slip, slip transition, and friction reloading. The theoretical models of above interface mechanical problems are given. PMID:24977189

  19. Global gene expression analysis for evaluation and design of biomaterials

    Directory of Open Access Journals (Sweden)

    Nobutaka Hanagata, Taro Takemura and Takashi Minowa

    2010-01-01

    Full Text Available Comprehensive gene expression analysis using DNA microarrays has become a widespread technique in molecular biological research. In the biomaterials field, it is used to evaluate the biocompatibility or cellular toxicity of metals, polymers and ceramics. Studies in this field have extracted differentially expressed genes in the context of differences in cellular responses among multiple materials. Based on these genes, the effects of materials on cells at the molecular level have been examined. Expression data ranging from several to tens of thousands of genes can be obtained from DNA microarrays. For this reason, several tens or hundreds of differentially expressed genes are often present in different materials. In this review, we outline the principles of DNA microarrays, and provide an introduction to methods of extracting information which is useful for evaluating and designing biomaterials from comprehensive gene expression data.

  20. DESIGN EVALUATIONS OF DOUBLE ROTOR SWITCHED RELUCTANCE MACHINE

    Directory of Open Access Journals (Sweden)

    C.V. ARAVIND

    2016-02-01

    Full Text Available The absence of magnets makes the reluctance machine typical for low cogging operations with the torque depending on the stator rotor interaction area. The air gap between stator pole and rotor pole gives a huge effect on the reluctance variation. The primitive double rotor switched reluctance machine lags to improvise the effect of the ripple value though the torque density is higher compared to conventional machines. An optimised circular hole position and dimensioned in the stator pole of lowers the torque ripple and reduce the acoustic noise as presented in this paper. A comparative evaluation of the conventional double rotor machine with this improved structure is done through numerical design and evaluations for the same sizing. It is found that the motor constant square density. It is found that the double rotor switched reluctance machine is improved by 140% to conventional machine.

  1. A design thinking approach to evaluating interprofessional education.

    Science.gov (United States)

    Cahn, Peter S; Bzowyckyj, Andrew; Collins, Lauren; Dow, Alan; Goodell, Kristen; Johnson, Alex F; Klocko, David; Knab, Mary; Parker, Kathryn; Reeves, Scott; Zierler, Brenda K

    2016-05-01

    The complex challenge of evaluating the impact of interprofessional education (IPE) on patient and community health outcomes is well documented. Recently, at the Radcliffe Institute for Advanced Study in the United States, leaders in health professions education met to help generate a direction for future IPE evaluation research. Participants followed the stages of design thinking, a process for human-centred problem solving, to reach consensus on recommendations. The group concluded that future studies should focus on measuring an intermediate step between learning activities and patient outcomes. Specifically, knowing how IPE-prepared students and preceptors influence the organisational culture of a clinical site as well as how the culture of clinical sites influences learners' attitudes about collaborative practice will demonstrate the value of educational interventions. With a mixed methods approach and an appreciation for context, researchers will be able to identify the factors that foster effective collaborative practice and, by extension, promote patient-centred care.

  2. Global gene expression analysis for evaluation and design of biomaterials

    International Nuclear Information System (INIS)

    Hanagata, Nobutaka; Takemura, Taro; Minowa, Takashi

    2010-01-01

    Comprehensive gene expression analysis using DNA microarrays has become a widespread technique in molecular biological research. In the biomaterials field, it is used to evaluate the biocompatibility or cellular toxicity of metals, polymers and ceramics. Studies in this field have extracted differentially expressed genes in the context of differences in cellular responses among multiple materials. Based on these genes, the effects of materials on cells at the molecular level have been examined. Expression data ranging from several to tens of thousands of genes can be obtained from DNA microarrays. For this reason, several tens or hundreds of differentially expressed genes are often present in different materials. In this review, we outline the principles of DNA microarrays, and provide an introduction to methods of extracting information which is useful for evaluating and designing biomaterials from comprehensive gene expression data. (topical review)

  3. Multinational design evaluation programme. Annual Report April 2016-April 2017

    International Nuclear Information System (INIS)

    2017-08-01

    The Multinational Design Evaluation Program (MDEP) is a multinational initiative to leverage the resources and knowledge of national regulatory authorities that are currently, or will shortly be, undertaking the review of new reactor power plant designs. MDEP was launched in 2006. In the past ten years, MDEP's reputation as an effective organisation for leveraging the resources and experiences of multiple nations in the regulatory review of new reactors has grown significantly. As a result, the portfolio of new reactor designs that are being addressed have increased from two in 2006 to five in 2017, with a possibility of adding more new reactor designs in the coming years. MDEP's membership has grown from the original 10 national regulators to 15. Over the past year, MDEP design specific working groups have all completed their common positions to address the impact of the Fukushima Daiichi nuclear power plant accident on new reactor designs. New reactor commissioning activities are a major part of all design specific working groups. The EPR and AP1000 Working Groups are particularly active in this area, as together they are overseeing 12 new reactor constructions worldwide. The design specific working groups have finalised a common position to provide high-level guidance to applicants and licensees that wish to take credit for a first plant only test (FPOT). This common position was first implemented in March 2017 at the Taishan 1 plant in China, where regulators and licensees from the United Kingdom, France and Finland witnessed reactor pressure vessel internals vibration tests. The FPOT marked a significant milestone for MDEP since it provided a unique opportunity for regulators involved to demonstrate the efficiency of using common positions to effectively collaborate and share information on test results. This model should be followed as much as possible in other MDEP co-operation areas. Another significant step in multinational regulatory co

  4. Tailoring intervention procedures to routine primary health care practice; an ethnographic process evaluation

    Directory of Open Access Journals (Sweden)

    Bruijnzeels Marc

    2007-08-01

    Full Text Available Abstract Background Tailor-made approaches enable the uptake of interventions as they are seen as a way to overcome the incompatibility of general interventions with local knowledge about the organisation of routine medical practice and the relationship between the patients and the professionals in practice. Our case is the Quattro project which is a prevention programme for cardiovascular diseases in high-risk patients in primary health care centres in deprived neighbourhoods. This programme was implemented as a pragmatic trial and foresaw the importance of local knowledge in primary health care and internal, or locally made, guidelines. The aim of this paper is to show how this prevention programme, which could be tailored to routine care, was implemented in primary care. Methods An ethnographic design was used for this study. We observed and interviewed the researchers and the practice nurses. All the research documents, observations and transcribed interviews were analysed thematically. Results Our ethnographic process evaluation showed that the opportunity of tailoring intervention procedures to routine care in a pragmatic trial setting did not result in a well-organised and well-implemented prevention programme. In fact, the lack of standard protocols hindered the implementation of the intervention. Although it was not the purpose of this trial, a guideline was developed. Despite the fact that the developed guideline functioned as a tool, it did not result in the intervention being organised accordingly. However, the guideline did make tailoring the intervention possible. It provided the professionals with the key or the instructions needed to achieve organisational change and transform the existing interprofessional relations. Conclusion As tailor-made approaches are developed to enable the uptake of interventions in routine practice, they are facilitated by the brokering of tools such as guidelines. In our study, guidelines facilitated

  5. Structural analysis and evaluation for the design of pressure vessel

    International Nuclear Information System (INIS)

    Arai, K.; Uragami, K.; Funada, T.; Baba, K.; Kira, T.

    1977-01-01

    For the design of pressure vessel, the detailed structural analysis such as the fatigue analysis under operating conditions is required by ASME Code or Japanese regulation. Accordingly, it should be verified by the analysis that the design of the pressure vessel is in compliance with the stress limitation defined in the Code or the regulation. However, it was apparent that the analysis is very complicated and takes a lot of time to evaluate in accordance with the Code requirements. Thereupon we developed the computer program by which we can perform the stress analysis with correctness and comparatively in a short period of design work reflecting the calculation results on detailed drawings to be used for fabrication. The computer program is controlled in combination with the system of the design work and out put list of the program can be directly used for the stress analysis report which is issued to customers. In addition to the above computer program, we developed the specific three dimensional finite element computer program to make sure of the structural integrity of the vessel head and flanges which are most complex for the analysis compared with the stress distribution measured by strain gauges on the vessel head and flange. Besides the structural analysis, the fracture mechanics analysis for the purpose of preventing the pressure vessel from the brittle fracture during heat-up and cool-down operation is also important and thereby we showed herein that the pressure vessel is in safety against the brittle fracture for the specified operating conditions. As a result of the above-mentioned analysis, the pressure vessel is designed with safety from the stand-points of the structural intensity and the fracture mechanics. (auth.)

  6. Design and Performance Evaluation of a Combined DHX unit for SFR Design Application

    International Nuclear Information System (INIS)

    Eoh, Jaehyuk; Kim, Dehee; Park, Chang-Gyu; Jeong, Ji-Young

    2015-01-01

    Based on a higher operating temperature with excellent thermal conductivity and larger thermal inertia of liquid sodium coolant, the SFR system has employed passive safety systems to ensure reliable decay heat removal (DHR) and consequential plant safety enhancement. Although a passive type DHR system has many advantages over an active one, designing a well coordinated passive system is usually more difficult than designing an effective active system. This is mainly because a cooling flow control is made directly by the system designer in an active system, while it is determined automatically by an intricate balance between the flow head loss and natural circulation head generation obtained from the density difference through the whole thermal flow system. To this end, securing a sufficient natural-circulation flow becomes one of the primary challenges for designing a reliable and successful Dh system in passive. In a current pool-type Sf design, an internal cooling flow path from the hot sodium pool to the cold pool is somewhat ambiguous owing to the split flow ratio formed in parallel paths between the intermediate heat exchangers (IHXs) and decay heat exchangers (DHXs), which results in a large uncertainty in the DHX shell-side flowrate and corresponding heat transfer to the DHR sodium loops. To improve passive the DHR performance, we proposed a new design concept with a simplified flow path from the hot pool to the cold pool through a unified flow path serially passing the DHX and IHX units. The present study aims at introducing the innovative design concept of the combined IHX-DHX unit and evaluating its design features in view of the heat transfer capability. From a comparison of the CHX performance designed by a one-dimensional approach with that made by a CFD analysis, it was quantitatively obtained that the difference in heat transfer rate is about 5.7%. It was also found that unexpected bypass flow in the shell-side CHX unit gave rise to a discrepancy

  7. Design and Evaluation of Microemulsion Gel System of Nadifloxacin

    Science.gov (United States)

    Shinde, Ujwala; Pokharkar, Sharda; Modani, Sheela

    2012-01-01

    Topical microemulsion systems for the antiacne agent, nadifloxacin were designed and developed to overcome the problems associated with the cutaneous delivery due to poor water solubility. The solubility of nadifloxacin in oils, surfactants and cosurfactants was evaluated to screen the components of the microemulsion. Various surfactants and cosurfactants were screened for their ability to emulsify the selected oily phase. The pseudoternary diagrams were constructed to identify the area of microemulsion existence. The influence of km (surfactant/cosurfactant) ratio on the microemulsion existence region was determined and optimum systems were designed. The systems were assessed for drug-loading efficiency and characterised for optical birefringence, pH and refractive index, robustness to dilution, globule size, drug content and thermodynamic stability. Optimised microemulsion systems were formulated into gel form and evaluated for viscosity, spreadability, drug content, ex vivo skin permeation and antibacterial activity. The maximum solubility of nadifloxacin in the microemulsion system was found to be 0.25%. The nadifloxacin microemulsions had a small and uniform globule size (67.3-121.23 nm). The stability results revealed that all formulations showed a stable globule size and the polydispersity index under stress conditions. Incorporation of nadifloxacin in microemulsion gel increased the ex vivo skin permeation and antibacterial activity when compared to marketed cream. PMID:23439454

  8. Design and Evaluation of Nextgen Aircraft Separation Assurance Concepts

    Science.gov (United States)

    Johnson, Walter; Ho, Nhut; Arutyunov, Vladimir; Laue, John-Luke; Wilmoth, Ian

    2012-01-01

    To support the development and evaluation of future function allocation concepts for separation assurance systems for the Next Generation Air Transportation System, this paper presents the design and human-in-the-loop evaluation of three feasible function allocation concepts that allocate primary aircraft separation assurance responsibilities and workload to: 1) pilots; 2) air traffic controllers (ATC); and 3) automation. The design of these concepts also included rules of the road, separation assurance burdens for aircraft of different equipage levels, and utilization of advanced weather displays paired with advanced conflict detection and resolution automation. Results of the human-in-the-loop simulation show that: a) all the concepts are robust with respect to weather perturbation; b) concept 1 (pilots) had highest throughput, closest to assigned spacing, and fewest violations of speed and altitude restrictions; c) the energy of the aircraft during the descent phase was better managed in concepts 1 and 2 (pilots and ATC) than in concept 3 (automation), in which the situation awareness of pilots and controllers was lowest, and workload of pilots was highest. The paper also discusses further development of these concepts and their augmentation and integration with future air traffic management tools and systems that are being considered for NextGen.

  9. Post design evaluation (ageing mechanisms, effects, management, monitoring, PSR, ISI)

    International Nuclear Information System (INIS)

    Ichikawa, Toshio

    2001-01-01

    Although the nuclear plant was designed for the purpose of the 30-year life the early stages of construction, it also already has the plant abolished by passing in 30 years. There is a plant under operation and a plant that is employed variously, extends the original life and continues operation now, and the plant that is going to be abolished politically is before a life. By using a nuclear plant for a long period of time, damage. by the influence of irradiation, wear of slipping, corrosion, etc. appears. When this degradation is left, the serious accident is caused. In this lecture, refer to Assessment and management of ageing of major nuclear power plant components important to safety, Oct. 1999 of IAEA. A point of view from guide is introduced about management of the mechanism in the secular degradation mode expected by operating for a long period of time, the influence of secular degradation, and influence, monitoring technology, periodical safe evaluation, and a periodic inspection. And raises and explains the correspondence situation of secular degradation, and the example of evaluation of PSR and ISI equipment. The aging mechanism for reactor vessel internal components considered are related to embrittlement, fatigue, corrosion, radiation induced creep, relaxation and swelling, and mechanical wear. This lecture includes; monitoring methods, a description of periodic safety reviews and a sample of seismic design periodic safety report for the reactor internals

  10. Maintainability design and evaluation of mechanical systems based on tribology

    International Nuclear Information System (INIS)

    Wani, M.F.; Gandhi, O.P.

    2002-01-01

    Maintainability of mechanical systems based on tribology is suggested and evaluated in this paper. Tribo-features of mechanical systems, which characterise maintainability are identified and are modelled in terms of tribo-maintainability digraph. The nodes in the digraph represent the tribo-features and edges represent the degree of influence among the features. A matrix, one to one representation of the digraph, is defined to develop system maintainability expression (SPF-t) based on the tribology. It is also useful in comparing the various design alternatives from tribo-maintainability point of view. Maintainability is evaluated from the tribo-maintainability index, obtained from SPF-t (i.e. permanent of the matrix) by substituting the numerical values of the features and their interdependence. A higher value of the index implies better maintainability of the systems. The proposed methodology also guides designers in enhancing the maintainability of a system by appropriately incorporating tribo-features. An example to illustrate the methodology is also presented

  11. Multinational design evaluation programme. Annual Report April 2015-April 2016

    International Nuclear Information System (INIS)

    2016-05-01

    The Multinational Design Evaluation Programme (MDEP) is a multinational initiative to leverage the resources and knowledge of national regulatory authorities that are, or will shortly be, undertaking the review of new reactor power plant designs. MDEP incorporates a broad range of activities including enhancing multilateral co-operation within existing regulatory frameworks, and increasing multinational convergence of codes, standards, guides, and safety goals. A key concept throughout the work of MDEP is that national regulators retain sovereign authority for all licensing and regulatory decisions. Working groups are implementing the activities in accordance with programme plans with specific activities and goals, and have established the necessary interfaces both within and outside of MDEP. This report provides a status of the programme after its eighth year of implementation. Content: Executive Summary; 1 - Introduction; 2 - Programme goals and outcomes; 3 - Programme implementation (Membership, Organizational structure, MDEP Library, Common positions); 4 - Interactions with other organizations; 5 - Current activities (EPR Working Group (EPRWG), AP1000 Working Group (AP1000WG), APR1400 Design-specific Working Group (APR1400WG), VVER Working Group (VVERWG), ABWR Working Group (ABWRWG), Vendor Inspection Co-operation Working Group (VICWG), Codes and Standards Working Group (CSWG), Digital Instrumentation and Controls Working Group (DICWG); 6 - Interim results; 7 - Next steps - future of the programme; appendix 1: List of abbreviations and acronyms; Appendix 2: Revised documents and publications; Appendix 3: Photographs of reactors considered within MDEP

  12. Designing workload analysis questionnaire to evaluate needs of employees

    Science.gov (United States)

    Astuti, Rahmaniyah Dwi; Navi, Muhammad Abdu Haq

    2018-02-01

    Incompatibility between workload with work capacity is one of main problem to make optimal result. In case at the office, there are constraints to determine workload because of non-repetitive works. Employees do work based on the targets set in a working period. At the end of the period is usually performed an evaluation of employees performance to evaluate needs of employees. The aims of this study to design a workload questionnaire tools to evaluate the efficiency level of position as indicator to determine needs of employees based on the Indonesian State Employment Agency Regulation on workload analysis. This research is applied to State-Owned Enterprise PT. X by determining 3 positions as a pilot project. Position A is held by 2 employees, position B is held by 7 employees, and position C is held by 6 employees. From the calculation result, position A has an efficiency level of 1,33 or "very good", position B has an efficiency level of 1.71 or "enough", and position C has an efficiency level of 1.03 or "very good". The application of this tools giving suggestion the needs of employees of position A is 3 people, position B is 5 people, and position C is 6 people. The difference between the number of employees and the calculation result is then analyzed by interviewing the employees to get more data about personal perception. It can be concluded that this workload evaluation tools can be used as an alternative solution to evaluate needs of employees in office.

  13. Measurement-Based Performance Evaluation of Advanced MIMO Transceiver Designs

    Directory of Open Access Journals (Sweden)

    Schneider Christian

    2005-01-01

    Full Text Available This paper describes the methodology and the results of performance investigations on a multiple-input multiple-output (MIMO transceiver scheme for frequency-selective radio channels. The method relies on offline simulations and employs real-time MIMO channel sounder measurement data to ensure a realistic channel modeling. Thus it can be classified in between the performance evaluation using some predefined channel models and the evaluation of a prototype hardware in field experiments. New aspects for the simulation setup are discussed, which are frequently ignored when using simpler model-based evaluations. Example simulations are provided for an iterative ("turbo" MIMO equalizer concept. The dependency of the achievable bit error rate performance on the propagation characteristics and on the variation in some system design parameters is shown, whereas the antenna constellation is of particular concern for MIMO systems. Although in many of the considered constellations turbo MIMO equalization appears feasible in real field scenarios, there exist cases with poor performance as well, indicating that in practical applications link adaptation of the transmitter and receiver processing to the environment is necessary.

  14. Multinational design evaluation programme - Annual report March 2013-March 2014

    International Nuclear Information System (INIS)

    2014-04-01

    The Multinational Design Evaluation Programme (MDEP) is a multinational initiative to leverage the resources and knowledge of national regulatory authorities who are, or will shortly be, undertaking the review of new reactor power plant designs. MDEP incorporates a broad range of activities including enhancing multilateral cooperation within existing regulatory frameworks, and increasing multinational convergence of codes, standards, guides, and safety goals. A key concept throughout the work of MDEP is that national regulators retain sovereign authority for all licensing and regulatory decisions. Working groups are implementing the activities in accordance with programme plans with specific activities and goals, and have established the necessary interfaces both within and outside of the MDEP members. In the past year, MDEP has expanded to include cooperation on the VVER and ABWR designs and additional members have begun participating in the programme to share their experiences on these design reviews. This report provides the current status of the programme. Significant progress is being made on the overall MDEP goals of increased cooperation and enhanced convergence of requirements and practices. In addition, the lessons learnt from the 11 March 2011, events at the Fukushima Daiichi nuclear power plant are being incorporated into MDEP activities through the programme plans of design-specific working groups (DSWG). On this topic, the EPR Working Group has issued a common position which will be supplemented by five technical appendices by the end of 2014. Other DSWG are in the process of drafting such common positions. Several DSWGs' are facilitating the MDEP programme goal of enhanced cooperation: the EPRWG, the Vendor Inspection Cooperation Working Group (VICWG), the Digital Instrumentation and Controls Working Group (DICWG), the Codes and Standards Working Group (CSWG). Accomplishments to date provide confidence that the MDEP membership, structure and processes

  15. Conceptual process design and economic analysis of a process based on liquid-liquid extraction for the recovery of glycols from aqueous streams

    NARCIS (Netherlands)

    Garcia Chavez, L.Y.; Schuur, Boelo; de Haan, A.B.

    2013-01-01

    The recovery of monoethylene glycol (MEG) and 1,2-propylene glycol (PG) from aqueous streams via liquid–liquid extraction (LLE) using a tailor-made ionic liquid [TOA MNaph] is evaluated as an alternative technology to conventional triple effect evaporation of water. In this paper, the conceptual

  16. Designing the Cash and Counseling Demonstration and Evaluation.

    Science.gov (United States)

    Doty, Pamela; Mahoney, Kevin J; Simon-Rusinowitz, Lori

    2007-02-01

    The Cash and Counseling Demonstration and Evaluation (CCDE) was designed as an experiment in shifting the paradigm in home and community-based long-term care from a professional/bureaucratic model of service delivery to one emphasizing consumer choice and control. The experimental intervention was an individualized budget offered in lieu of traditional Medicaid-covered services, such as agency-delivered aide services or a plan of care developed and coordinated by a professional case-manager, which typically involves authorization for several different providers to deliver a range of services. Within the spending limits established by their budgets, program participants were largely free to choose the types and amounts of paid services and supports they judged best able to meet their disability-related personal assistance needs. Medicaid beneficiaries in selected states who volunteered to participate. In all of the participating state Medicaid programs, beneficiaries eligible to participate included elders and younger adults with chronic disabilities and, in one state, adults and children with mental retardation/developmental disabilities could also participate. Minor children and adults with cognitive impairment could participate via representatives (family or friends who agreed to assist them in managing their services or to act as their surrogate decision-makers). Members of the CCDE management team describe the rationale for and implications of key design decisions. Key design decisions included the choice of research methodology (random assignment of CCDE participants in each state to treatment and control groups), selection of the state sites (AR, FL, NJ, NY), and the need for the CCDE to comply with federal waiver requirements for Medicaid research and demonstration projects. Principle Findings. The CCDE design was successfully implemented in three of the four state Medicaid programs selected for participation. The successful implementation of the CCDE

  17. Design, synthesis and biological evaluation of novel desmuramyldipeptide analogs.

    Science.gov (United States)

    Jakopin, Žiga; Corsini, Emanuela; Gobec, Martina; Mlinarič-Raščan, Irena; Dolenc, Marija Sollner

    2011-09-01

    A series of novel desmuramyldipeptides have been designed and synthesized as part of our search for therapeutically useful muramyldipeptide (MDP) analogs. Their immunomodulatory properties were initially assessed in vitro, evaluating their effect on lipopolysaccharide (LPS)-induced cytokine release in THP-1 cells. Following the initial screening, selected compounds were further investigated for immunomodulatory properties using LPS and phorbol 12-myristate 13-acetate (PMA)/ionomycin-stimulated human peripheral blood mononuclear cells. The results confirmed the immunomodulatory properties of some of the synthesized desmuramyldipeptide analogs. Taken together, presented data confirmed the immunostimulatory effect of compound 44, MDP derivative incorporating a pyrido-fused [1,2]-benzisothiazole moiety, while for compounds 32 and 39, indole scaffold-based derivatives of MDP, an immunosuppressive effect was observed. Further studies will be necessary to address their potential therapeutic use as immunomodulatory drugs, both as immunostimulants or anti-inflammatory agents. Copyright © 2011 Elsevier Masson SAS. All rights reserved.

  18. A passive exoskeleton with artificial tendons: design and experimental evaluation.

    Science.gov (United States)

    van Dijk, Wietse; van der Kooij, Herman; Hekman, Edsko

    2011-01-01

    We developed a passive exoskeleton that was designed to minimize joint work during walking. The exoskeleton makes use of passive structures, called artificial tendons, acting in parallel with the leg. Artificial tendons are elastic elements that are able to store and redistribute energy over the human leg joints. The elastic characteristics of the tendons have been optimized to minimize the mechanical work of the human leg joints. In simulation the maximal reduction was 40 percent. The performance of the exoskeleton was evaluated in an experiment in which nine subjects participated. Energy expenditure and muscle activation were measured during three conditions: Normal walking, walking with the exoskeleton without artificial tendons, and walking with the exoskeleton with the artificial tendons. Normal walking was the most energy efficient. While walking with the exoskeleton, the artificial tendons only resulted in a negligibly small decrease in energy expenditure. © 2011 IEEE

  19. Design & Evaluation of an Accessible Hybrid Violin Platform

    DEFF Research Database (Denmark)

    Overholt, Daniel; Gelineck, Steven

    2014-01-01

    We introduce and describe the initial evaluation of a new accessible (easily replicable) augmented violin prototype. Our research is focused on the user experience when playing such hybrid physical- digital instruments, and exploration of novel interactive performance techniques. The goal of wider...... platform accessibility for players and other researchers is approached via a simple ‘do-it-yourself’ design described herein. All hardware and software elements are open- source, and the build process requires minimal electronics skills. Cost has also been kept to a minimum where possible. Our initial...... that incorporates orientation/gesture sensors as well, with the resulting sound amplified and rendered via small speakers mounted directly to the instrument. The platform combines all necessary elements for digitally-mediated interactive performance; the need for a traditional computer only arises when developing...

  20. Designing and evaluating risk-based surveillance systems

    DEFF Research Database (Denmark)

    Willeberg, Preben; Nielsen, Liza Rosenbaum; Salman, Mo

    2012-01-01

    Risk-based surveillance systems reveal occurrence of disease or infection in a sample of population units, which are selected on the basis of risk factors for the condition under study. The purpose of such systems for supporting practical animal disease policy formulations and management decisions...... with prudent use of resources while maintaining acceptable system performance. High-risk category units are selected for testing by identification of the presence of specific high-risk factor(s), while disregarding other factors that might also influence the risk. On this basis we argue that the most...... applicable risk estimate for use in designing and evaluating a risk-based surveillance system would be a crude (unadjusted) relative risk, odds ratio or apparent prevalence. Risk estimates found in the published literature, however, are often the results of multivariable analyses implicitly adjusting...

  1. Improved field experimental designs and quantitative evaluation of aquatic ecosystems

    Energy Technology Data Exchange (ETDEWEB)

    McKenzie, D.H.; Thomas, J.M.

    1984-05-01

    The paired-station concept and a log transformed analysis of variance were used as methods to evaluate zooplankton density data collected during five years at an electrical generation station on Lake Michigan. To discuss the example and the field design necessary for a valid statistical analysis, considerable background is provided on the questions of selecting (1) sampling station pairs, (2) experimentwise error rates for multi-species analyses, (3) levels of Type I and II error rates, (4) procedures for conducting the field monitoring program, and (5) a discussion of the consequences of violating statistical assumptions. Details for estimating sample sizes necessary to detect changes of a specified magnitude are included. Both statistical and biological problems with monitoring programs (as now conducted) are addressed; serial correlation of successive observations in the time series obtained was identified as one principal statistical difficulty. The procedure reduces this problem to a level where statistical methods can be used confidently. 27 references, 4 figures, 2 tables.

  2. Design of Graphic Aggregation Model for Evaluation of Energy Systems

    International Nuclear Information System (INIS)

    An, Sang Ha; Jeong, Yong Hoon; Chang, Won Joon; Chang, Soon Heung; Kim, Sung Ho; Kim, Tae Woon

    2006-01-01

    Korea is meeting the growing electric power needs by mix of nuclear, fossil, hydro energy and so on. But we can not depend on fossil energy forever, and the people's concern about environment has been changed. So it is time to plan future energy mix considering multiple parameters such as economics, environment, social, energy security, etc. A multiple aggregation model has been used for decision making process in which multiple variables should be considered like energy mix. In this context, we designed Graphic Aggregation Model for Evaluation of energy systems (GAME) for the dynamic analysis of decision on the energy systems. It can support Analytic Hierarchy Process (AHP) analysis based on Graphic User Interface

  3. THE IMPORTANCE OF WEB DESIGN: VISUAL DESIGN EVALUATION OF DESTINATION WEB SITES

    OpenAIRE

    Fırlar, Belma; Okat Özdem, Özen

    2013-01-01

    As in the literature, the researchs about web site efficiency are mostly about site context. The analysis about function are mostly superficial. Whereas, controlling every little part of a web site respective is a necessity to show its efficiency. Here in this context in the study of perception and response event web sites that play an important role in visual design criteria are below the lens as featured and the web sites evaulated by heuristic evaluation method.The research focus of this s...

  4. Design, modeling, simulation and evaluation of a distributed energy system

    Science.gov (United States)

    Cultura, Ambrosio B., II

    This dissertation presents the design, modeling, simulation and evaluation of distributed energy resources (DER) consisting of photovoltaics (PV), wind turbines, batteries, a PEM fuel cell and supercapacitors. The distributed energy resources installed at UMass Lowell consist of the following: 2.5kW PV, 44kWhr lead acid batteries and 1500W, 500W & 300W wind turbines, which were installed before year 2000. Recently added to that are the following: 10.56 kW PV array, 2.4 kW wind turbine, 29 kWhr Lead acid batteries, a 1.2 kW PEM fuel cell and 4-140F supercapacitors. Each newly added energy resource has been designed, modeled, simulated and evaluated before its integration into the existing PV/Wind grid-connected system. The Mathematical and Simulink model of each system was derived and validated by comparing the simulated and experimental results. The Simulated results of energy generated from a 10.56kW PV system are in good agreement with the experimental results. A detailed electrical model of a 2.4kW wind turbine system equipped with a permanent magnet generator, diode rectifier, boost converter and inverter is presented. The analysis of the results demonstrates the effectiveness of the constructed simulink model, and can be used to predict the performance of the wind turbine. It was observed that a PEM fuel cell has a very fast response to load changes. Moreover, the model has validated the actual operation of the PEM fuel cell, showing that the simulated results in Matlab Simulink are consistent with the experimental results. The equivalent mathematical equation, derived from an electrical model of the supercapacitor, is used to simulate its voltage response. The model is completely capable of simulating its voltage behavior, and can predict the charge time and discharge time of voltages on the supercapacitor. The bi-directional dc-dc converter was designed in order to connect the 48V battery bank storage to the 24V battery bank storage. This connection was

  5. ACS sampling system: design, implementation, and performance evaluation

    Science.gov (United States)

    Di Marcantonio, Paolo; Cirami, Roberto; Chiozzi, Gianluca

    2004-09-01

    By means of ACS (ALMA Common Software) framework we designed and implemented a sampling system which allows sampling of every Characteristic Component Property with a specific, user-defined, sustained frequency limited only by the hardware. Collected data are sent to various clients (one or more Java plotting widgets, a dedicated GUI or a COTS application) using the ACS/CORBA Notification Channel. The data transport is optimized: samples are cached locally and sent in packets with a lower and user-defined frequency to keep network load under control. Simultaneous sampling of the Properties of different Components is also possible. Together with the design and implementation issues we present the performance of the sampling system evaluated on two different platforms: on a VME based system using VxWorks RTOS (currently adopted by ALMA) and on a PC/104+ embedded platform using Red Hat 9 Linux operating system. The PC/104+ solution offers, as an alternative, a low cost PC compatible hardware environment with free and open operating system.

  6. Evaluation of divertor conceptual designs for a fusion power plant

    International Nuclear Information System (INIS)

    Ferrari, M.; Giancarli, L.; Kleefeldt, K.; Nardi, C.; Roedig, M.; Reimann, J.; Salavy, J.F.

    2001-01-01

    In the frame of the preliminary study of plants suitable for the energy production from the fusion power, particular emphasis has been given on the divertor studies. Since a significant percentage of the power generated from the fusion process is absorbed in the divertor, the thermal efficiency of the power conversion cycle requires a high coolant outlet temperature of the divertor, leading to solutions that are different from those adopted for the present experimental fusion plants. Therefore, copper alloys having extremely high thermal conductivity, cannot be used as structural material for this kind of devices. The most suitable coolants to be used in the divertor are water, helium and liquid metals. A conceptual design study has been developed for each of these three fluids, with the aim to evaluate the maximum allowable thermal flux at the divertor target plate and the R and D requirements for each solution. While a water-cooled divertor can be designed with a limited R and D effort, the development of helium or liquid metal cooled divertors requires a more engaging R and D program

  7. Safety Evaluation of Kartini Reactor Based on Instrumentation System Design

    International Nuclear Information System (INIS)

    Tjipta Suhaemi; Djen Djen Dj; Itjeu K; Johnny S; Setyono

    2003-01-01

    The safety of Kartini reactor has been evaluated based on instrumentation system aspect. The Kartini reactor is designed by BATAN. Design power of the reactor is 250 kW, but it is currently operated at 100 kW. Instrumentation and control system function is to monitor and control the reactor operation. Instrumentation and control system consists of safety system, start-up and automatic power control, and process information system. The linear power channel and logarithmic power channel are used for measuring power. There are 3 types of control rod for controlling the power, i.e. safety rod, shim rod, and regulating rod. The trip and interlock system are used for safety. There are instrumentation equipment used for measuring radiation exposure, flow rate, temperature and conductivity of fluid The system of Kartini reactor has been developed by introducing a process information system, start-up system, and automatic power control. It is concluded that the instrumentation of Kartini reactor has followed the requirement and standard of IAEA. (author)

  8. Proton exchange fuel cell : the design, construction and evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Heinzen, M.R.; Simoes, G.C.; Da Silva, L. [Univ. do Vale do Itajai, Sao Jose, SC (Brazil). Lab. de Pesquisa em Energia; Fiori, M.A.; Paula, M.M.S. [Univ. do Extremo Sul Catarinense, Santa Catarina (Brazil). Lab. de Sintese de Complexos Multifuncionais; Benavides, R. [Centro de Investigacion en Quimica Aplicada, Coahuila (Mexico)

    2010-07-15

    Polymer electrolyte membrane fuel cells (PEMFC) convert the chemical energy stored in the fuel directly into electrical energy without intermediate steps. The PEMFC operates at a relatively low operating temperature making it a good choice for mobile applications, but a high power density is needed in order to decrease the total weight of the vehicles. This paper presented a simple methodology to construct a PEMFC-type fuel cell, with particular reference to the gaseous diffuser, cell structure, the fixing plate, mounting bracket, gas distribution plates, and the membrane electrode assembly (MEA). The geometric design and meshing of the PEMFC were also described. The electrode was made using graphite with flow-field geometry. The PEMFC was tested for 100 hour of continuous work, during which time the current and voltage produced were monitored in order to evaluate the performance of the PEMFC. The materials used in the preparation of the fuel cell proved to be suitable. There was no loss of efficiency during the tests. The most relevant aspects affecting the PEMFC design were examined in an effort to optimize the performance of the cell. 13 refs., 6 figs.

  9. Design, formulation and evaluation of caffeine chewing gum.

    Science.gov (United States)

    Aslani, Abolfazl; Jalilian, Fatemeh

    2013-01-01

    Caffeine which exists in drinks such as coffee as well as in drug dosage forms in the global market is among the materials that increase alertness and decrease fatigue. Compared to other forms of caffeine, caffeine gum can create faster and more prominent effects. In this study, the main goal is to design a new formulation of caffeine gum with desirable taste and assess its physicochemical properties. Caffeine gum was prepared by softening of gum bases and then mixing with other formulation ingredients. To decrease the bitterness of caffeine, sugar, aspartame, liquid glucose, sorbitol, manitol, xylitol, and various flavors were used. Caffeine release from gum base was investigated by mechanical chewing set. Content uniformity test was also performed on the gums. The gums were evaluated in terms of organoleptic properties by the Latin-Square design at different stages. After making 22 formulations of caffeine gums, F11 from 20 mg caffeine gums and F22 from 50 mg caffeine gums were chosen as the best formulation in organoleptic properties. Both types of gum released about 90% of their own drug content after 30 min. Drug content of 20 and 50 mg caffeine gum was about 18.2-21.3 mg and 45.7-53.6 mg respectively. In this study, 20 and 50 mg caffeine gums with suitable and desirable properties (i.e., good taste and satisfactory release) were formulated. The best flavor for caffeine gum was cinnamon. Both kinds of 20 and 50 mg gums succeeded in content uniformity test.

  10. Multinational Design Evaluation Programme. Annual Report - April 2014-April 2015

    International Nuclear Information System (INIS)

    2015-06-01

    The Multinational Design Evaluation Programme (MDEP) is a multinational initiative to leverage the resources and knowledge of national regulatory authorities who are, or will shortly be, undertaking the review of new reactor power plant designs. MDEP incorporates a broad range of activities including enhancing multilateral co-operation within existing regulatory frameworks, and increasing multinational convergence of codes, standards, guides and safety goals. A key concept throughout the work of MDEP is that national regulators retain sovereign authority for all licensing and regulatory decisions. Working groups are implementing the activities in accordance with programme plans with specific activities and goals, and have established the necessary interfaces both within and outside of MDEP. This report provides a status of the programme after its seventh year of implementation. Content: Executive summary; 1. Introduction; 2. Programme goals and outcomes; 3. Programme implementation (Membership, Organisational structure, MDEP Library, Common positions); 4. Interactions with other organisations; 5. Current activities (EPR Working Group (EPRWG), AP1000 Working Group (AP1000WG), APR1400 Working Group (APR1400WG), VVER Working Group (VVERWG), AVBWR Working Group (ABWRWG), Vendor Inspection Co-operation Working Group (VICWG), Codes and Standards Working Group (CSWG), Digital Instrumentation and Controls Working Group (DICWG)); 6. Interim results; 7. Next steps - Future of the programme; Appendix 1 - List of abbreviations and acronyms; Appendix 2 - Revised documents and publications; Appendix 3 - Photographs of reactors considered within MDEP

  11. Gasifier feed: Tailor-made from Illinois coals. Technical report, September 1, 1991--November 30, 1991

    Energy Technology Data Exchange (ETDEWEB)

    Ehrlinger, H.P. III

    1991-12-31

    The purpose of this research is to develop a coal slurry from waste streams using Illinois coal that is ideally suited for a gasification feed. The principle items to be studied are (1) methods of concentrating pyrite and decreasing other ash forming minerals into a high grade gasification feed using froth flotation and gravity separation techniques; (2) chemical and particle size analyses of coal slurries; (3) determination of how that slurry can be densified and to what degree of densification is optimum from the pumpability and combustibility analyses; and (4) reactivity studies.

  12. Tailor made: Towards a pedagogy for educating second-career teachers

    NARCIS (Netherlands)

    Tigchelaar, A.; Brouwer, N.; Vermunt, J. D.

    2010-01-01

    Many countries suffer from teacher shortages. One possible solution to this problem is to recruit second-career teachers. These second-career teachers form an intriguing group. They bring an abundance of previous experiences into a new, professional domain. The purpose of this study is to identify

  13. Tailor-made : towards a pedagogy for educating second-career teachers

    NARCIS (Netherlands)

    Tigchelaar, A.E.; Brouwer, C.N.; Vermunt, J.D.H.M.

    2010-01-01

    Many countries suffer from teacher shortages. One possible solution to this problem is to recruit second-career teachers. These second-career teachers form an intriguing group. They bring an abundance of previous experiences into a new, professional domain. The purpose of this study is to identify

  14. Co-Opetition Provides the Halifax with Tailor-Made Training

    Science.gov (United States)

    Education & Training, 2002

    2002-01-01

    Describes the co-operation between Cranfield University, Trans4mation management consultancy and ProActive outdoor activities provider, in a new leadership programme for UK bank Halifax plc. Shows that the three organizations, which might normally have been competing against each other, had to devise ways of tearing down barriers, communicating…

  15. The future belongs to diversity. Tailor-made products for successful mobility solutions

    Energy Technology Data Exchange (ETDEWEB)

    Weber, Thomas [Daimler AG, Stuttgart (Germany). Group Research and Mercedes-Benz Cars Development

    2013-08-01

    What will the car of tomorrow look like? And how are the mobility needs of people changing? Aided by market research and through customer feedback, among other things, as well as using technology monitoring and future research, development experts at Daimler and Mercedes-Benz are finding answers to basic questions like these. These disciplines have a long tradition in the company. International research teams have worked for over 30 years on anticipating long-term trends and societal developments in order to transfer these to the topic of mobility. These proactive work methods - ''thinking ahead'' - generate new solutions in anticipation of changed conditions and new customer requirements rather than as a reaction to them. (orig.)

  16. Crystal morphology modification by the addition of tailor-made stereocontrolled poly(N-isopropyl acrylamide)

    DEFF Research Database (Denmark)

    Munk, Tommy; Baldursdottir, Stefania; Hietala, Sami

    2012-01-01

    . One such additive is the thermosensitive polymer poly(N-isopropyl acrylamide) (PNIPAM). The use of PNIPAM as a crystallization additive provides a possibility to affect viscosity at separation temperatures and nucleation and growth rates at higher temperatures. In this study, novel PNIPAM derivatives......; the morphology of crystals changed from needle to dendritic shape. Additionally, the amphiphilic nature of PNIPAM increased the solubility of nitrofurantoin in water. PNIPAMs with varying molecular weights and stereoregularities resulted in similar changes in the crystal habit of the drug regardless of whether...

  17. Crystal morphology modification by the addition of tailor-made stereocontrolled poly(N-isopropyl acrylamide).

    Science.gov (United States)

    Munk, Tommy; Baldursdottir, Stefania; Hietala, Sami; Rades, Thomas; Kapp, Sebastian; Nuopponen, Markus; Kalliomäki, Katriina; Tenhu, Heikki; Rantanen, Jukka

    2012-07-02

    The use of additives in crystallization of pharmaceuticals is known to influence the particulate properties critically affecting downstream processing and the final product performance. Desired functionality can be build into these materials, e.g. via optimized synthesis of a polymeric additive. One such additive is the thermosensitive polymer poly(N-isopropyl acrylamide) (PNIPAM). The use of PNIPAM as a crystallization additive provides a possibility to affect viscosity at separation temperatures and nucleation and growth rates at higher temperatures. In this study, novel PNIPAM derivatives consisting of both isotactic-rich and atactic blocks were used as additives in evaporative crystallization of a model compound, nitrofurantoin (NF). Special attention was paid to possible interactions between NF and PNIPAM and the aggregation state of PNIPAM as a function of temperature and solvent composition. Optical light microscopy and Raman and FTIR spectroscopy were used to investigate the structure of the NF crystals and possible interaction with PNIPAM. A drastic change in the growth mechanism of nitrofurantoin crystals as monohydrate form II (NFMH-II) was observed in the presence of PNIPAM; the morphology of crystals changed from needle to dendritic shape. Additionally, the amphiphilic nature of PNIPAM increased the solubility of nitrofurantoin in water. PNIPAMs with varying molecular weights and stereoregularities resulted in similar changes in the crystal habit of the drug regardless of whether the polymer was aggregated or not. However, with increased additive concentration slower nucleation and growth rates of the crystals were observed. Heating of the crystallization medium resulted in phase separation of the PNIPAM. The phase separation had an influence on the achieved crystal morphology resulting in fewer, visually larger and more irregular dendritic crystals. No proof of hydrogen bond formation between PNIPAM and NF was observed, and the suggested mechanism for the observed dendritic morphology is related to the steric hindrance phenomenon. PNIPAM can be used as a crystallization additive with an obvious effect on the growth of NF crystals.

  18. Continuous flow synthesis and characterization of tailor-made bare gold nanoparticles for use in SERS

    International Nuclear Information System (INIS)

    López -Lorente, Ángela I.; Valcárcel, Miguel; Mizaikoff, Boris

    2014-01-01

    We describe a method for the synthesis of gold nanoparticles in a stainless steel continuous flow tubular reactor using tetrachloroauric acid as a precursor but without using a classical reducing agent. Gold(III) ion is reduced by stainless steel to form gold nanoparticles which are collected at the end of the coil. A single-phase system is introduced that generates dispersed nanoparticles in the absence of reducing agents on their surface. By controlling flow rates and temperature, the size of the nanoparticles can be tuned in the range from 24 nm to 36 nm. The reproducibility of the preparation was investigated, relative standard deviation of both the wavelength of the peak and the intensity of the plasmonic absorption band were determined and found to vary by 0.15 % and 6.5 %, respectively. Flow synthesis is found to be an excellent alternative to chemical methods to produce stable gold nanoparticles of varying size in an efficiently way. The particles obtained also perform very well when used as a substrate in surface enhanced Raman scattering as shown by the characterization of carboxylated single walled carbon nanotubes. (author)

  19. Tailor-Made News: Meeting the demands of news users on mobile and social media

    NARCIS (Netherlands)

    Groot Kormelink, T.; Costera Meijer, I.

    2014-01-01

    Despite the technological possibilities for portable, personalized, and participatory news use, the public has not turned en masse from passive receivers who consume news on the producers' terms, into active users who tailor news to fit their personal preferences and practices. Unmistakably, some

  20. Energy conservation through behavioral change : Examining the effectiveness of a tailor-made approach

    NARCIS (Netherlands)

    Abrahamse, Wokje

    2007-01-01

    Households constitute an important target group when it comes to encouraging energy conservation. This dissertation provides an overview of the effectiveness of interventions aimed at encouraging households to reduce their energy use through behavioral changes. It also provides more insight into the

  1. A fast surrogate model tailor-made for real time control

    DEFF Research Database (Denmark)

    Borup, Morten; Thrysøe, Cecilie; Arnbjerg-Nielsen, Karsten

    A surrogate model of a detailed hydraulic urban drainage model is created for supplying inflow forecasts to an MPC model for 31 separate locations. The original model is subdivided into 66 relationships extracted from the original model. The surrogate model is 9000 times faster than the original...... model, with just a minor deviation from the original model results....

  2. Tailor-made conductive inks from cellulose nanofibrils for 3D printing of neural guidelines.

    Science.gov (United States)

    Kuzmenko, Volodymyr; Karabulut, Erdem; Pernevik, Elin; Enoksson, Peter; Gatenholm, Paul

    2018-06-01

    Neural tissue engineering (TE), an innovative biomedical method of brain study, is very dependent on scaffolds that support cell development into a functional tissue. Recently, 3D patterned scaffolds for neural TE have shown significant positive effects on cells by a more realistic mimicking of actual neural tissue. In this work, we present a conductive nanocellulose-based ink for 3D printing of neural TE scaffolds. It is demonstrated that by using cellulose nanofibrils and carbon nanotubes as ink constituents, it is possible to print guidelines with a diameter below 1 mm and electrical conductivity of 3.8 × 10 -1  S cm -1 . The cell culture studies reveal that neural cells prefer to attach, proliferate, and differentiate on the 3D printed conductive guidelines. To our knowledge, this is the first research effort devoted to using cost-effective cellulosic 3D printed structures in neural TE, and we suppose that much more will arise in the near future. Copyright © 2018 Elsevier Ltd. All rights reserved.

  3. Liquid foam templating - A route to tailor-made polymer foams.

    Science.gov (United States)

    Andrieux, Sébastien; Quell, Aggeliki; Stubenrauch, Cosima; Drenckhan, Wiebke

    2018-06-01

    Solid foams with pore sizes between a few micrometres and a few millimetres are heavily exploited in a wide range of established and emerging applications. While the optimisation of foam applications requires a fine control over their structural properties (pore size distribution, pore opening, foam density, …), the great complexity of most foaming processes still defies a sound scientific understanding and therefore explicit control and prediction of these parameters. We therefore need to improve our understanding of existing processes and also develop new fabrication routes which we understand and which we can exploit to tailor-make new porous materials. One of these new routes is liquid templating in general and liquid foam templating in particular, to which this review article is dedicated. While all solid foams are generated from an initially liquid(-like) state, the particular notion of liquid foam templating implies the specific condition that the liquid foam has time to find its "equilibrium structure" before it is solidified. In other words, the characteristic time scales of the liquid foam's stability and its solidification are well separated, allowing to build on the vast know-how on liquid foams established over the last 20 years. The dispersed phase of the liquid foam determines the final pore size and pore size distribution, while the continuous phase contains the precursors of the desired porous scaffold. We review here the three key challenges which need to be addressed by this approach: (1) the control of the structure of the liquid template, (2) the matching of the time scales between the stability of the liquid template and solidification, and (3) the preservation of the structure of the template throughout the process. Focusing on the field of polymer foams, this review gives an overview of recent research on the properties of liquid foam templates and summarises a key set of studies in the emerging field of liquid foam templating. It finishes with an outlook on future developments. Occasional references to non-polymeric foams are given if the analogy provides specific insight into a physical phenomenon. Copyright © 2018 Elsevier B.V. All rights reserved.

  4. Tailor-made three-dimensional hybrid scaffolds for cell cultures

    Energy Technology Data Exchange (ETDEWEB)

    Psycharakis, Stylianos; Melissinaki, Vasileia; Giakoumaki, Anastasia; Ranella, Anthi [Institute of Electronic Structure and Laser, Foundation for Research and Technology Hellas, PO Box 1527, 711 10 Heraklion, Crete (Greece); Tosca, Androniki, E-mail: ranthi@iesl.forth.gr [Department of Medicine, University of Crete, 710 03 Heraklion, Crete (Greece)

    2011-08-15

    The construction of the ideal three-dimensional scaffold for cell culture is one of the most intriguing topics in tissue engineering. It has been shown that cells can be cultured on most organic biomimetic materials, which now are losing popularity in favour of novel, hybrid systems. In this study, a series of photosensitive sol-gel hybrid materials, based on silicon-zirconium and silicon-titanium oxides, have been investigated for their suitability in three-dimensional scaffold fabrication. These materials can be structured by two-photon polymerization, a laser-based technique allowing the fabrication of micrometre-size structures with submicron resolution. The work presented here examined the effect of the organic/inorganic composition of the materials on cell behaviour and the establishment of a 'cell-culture friendly' environment. This is vital for cell adhesion, growth and differentiation, as the organic part of the material provides the soft matrix for cell growth, whereas the inorganic component gives the mechanical stability and rigidity of the three-dimensional structures. In addition, the use of femtosecond laser structuring permits the fabrication of a wide range of mechanically stable scaffolds of different sizes and shapes to be tested in terms of cell viability, proliferation and orientation.

  5. Malaria, HIV and sickle cell disease in Ghana : Towards tailor-made interventions

    NARCIS (Netherlands)

    Owusu, E.D.A.

    2018-01-01

    Ghana has made many strides in the fight against malaria. This research looked at the contribution of malaria transmission heterogeneity to malaria, and the effect of geographical overlap between malaria, HIV and sickle cell disease. Our systematic review of the interactions between HIV and SCD

  6. Tailor-made purified human platelet lysate concentrated in neurotrophins for treatment of Parkinson's disease.

    Science.gov (United States)

    Chou, Ming-Li; Wu, Joe-Wei; Gouel, Flore; Jonneaux, Aurélie; Timmerman, Kelly; Renn, Ting-Yi; Laloux, Charlotte; Chang, Hung-Ming; Lin, Liang-Tzung; Devedjian, Jean-Christophe; Devos, David; Burnouf, Thierry

    2017-10-01

    Human platelet lysates (PLs), which contain multiple neurotrophins, have been proposed for treating neurodegenerative disorders, including Parkinson's disease (PD). However, current PLs suspended in plasma have high protein content and contain fibrinogen/fibrin and, following activation, also proteolytic and thrombogenic enzymes. Upon brain administration, such PLs may saturate the cerebrospinal fluid and exert neurotoxicity. We assessed whether purified PLs, concentrated in neurotrophins, protected dopaminergic neurons in PD models. Platelet concentrates were collected by apheresis and centrifuged to eliminate plasma and recover the platelets. Platelets were lysed by freeze-thaw cycles, and the 10-fold concentrated platelet pellet lysates (PPLs) were heat-treated (at 56 °C for 30 min). The heat-treated PPLs were low in total proteins, depleted in both plasma and platelet fibrinogen, and devoid of thrombogenic and proteolytic activities. They exerted very high neuroprotective activity when non-oncogenic, Lund human mesencephalic (LUHMES) cells that had differentiated into dopaminergic neurons were exposed to the MPP + neurotoxin. Heat treatment improved the neuroprotection and inactivated the neurotoxic blood-borne hepatitis C virus. PPL did not induce inflammation in BV2 microglial cells and inhibited COX-2 expression upon lipopolysaccharide exposure. Intranasal administration in mice revealed (a) diffusion of neurotrophins in the striatum and cortex, and (b) MPTP intoxication neuroprotection in the substantia nigra and striatum and the absence of neuroinflammation. These dedicated heat-treated PPLs can be a safe and valuable candidate for a therapeutic strategy for PD. Copyright © 2017 Elsevier Ltd. All rights reserved.

  7. Tailor-made dimensions of diblock copolymer truncated micelles on a solid by UV irradiation.

    Science.gov (United States)

    Liou, Jiun-You; Sun, Ya-Sen

    2015-09-28

    We investigated the structural evolution of truncated micelles in ultrathin films of polystyrene-block-poly(2-vinylpyridine), PS-b-P2VP, of monolayer thickness on bare silicon substrates (SiOx/Si) upon UV irradiation in air- (UVIA) and nitrogen-rich (UVIN) environments. The structural evolution of micelles upon UV irradiation was monitored using GISAXS measurements in situ, while the surface morphology was probed using atomic force microscopy ex situ and the chemical composition using X-ray photoelectron spectroscopy (XPS). This work provides clear evidence for the interpretation of the relationship between the structural evolution and photochemical reactions in PS-b-P2VP truncated micelles upon UVIA and UVIN. Under UVIA treatment, photolysis and cross-linking reactions coexisted within the micelles; photolysis occurred mainly at the top of the micelles, whereas cross-linking occurred preferentially at the bottom. The shape and size of UVIA-treated truncated micelles were controlled predominantly by oxidative photolysis reactions, which depended on the concentration gradient of free radicals and oxygen along the micelle height. Because of an interplay between photolysis and photo-crosslinking, the scattering length densities (SLD) of PS and P2VP remained constant. In contrast, UVIN treatments enhanced the contrast in SLD between the PS shell and the P2VP core as cross-linking dominated over photolysis in the presence of nitrogen. The enhancement of the SLD contrast was due to the various degrees of cross-linking under UVIN for the PS and P2VP blocks.

  8. A lay prescription for tailor-made drugs--focus group reflections on pharmacogenomics

    DEFF Research Database (Denmark)

    Almarsdóttir, Anna Birna; Björnsdóttir, Ingunn; Traulsen, Janine Morgall

    2005-01-01

    the consequences of the Human Genome Project over the next 40 years, and asked to give advice to politicians and the pharmaceutical industry. A dominating theme in the focus groups was the expectation that drugs developed based on pharmacogenomics will be more expensive than conventional mass produced drugs...

  9. Tailor-made memory: natural differences in associative olfactory learning in two closely related wasp species

    NARCIS (Netherlands)

    Berg, van den M.

    2009-01-01

    Learning and memory formation are often seen as traits that are purely beneficial, but they are associated with metabolic costs as well. Since costs and gains of learning and memory are expected to vary between species, the ease and speed with which stable (consolidated) long-term memory (LTM) is

  10. Tailor-made three-dimensional hybrid scaffolds for cell cultures

    International Nuclear Information System (INIS)

    Psycharakis, Stylianos; Melissinaki, Vasileia; Giakoumaki, Anastasia; Ranella, Anthi; Tosca, Androniki

    2011-01-01

    The construction of the ideal three-dimensional scaffold for cell culture is one of the most intriguing topics in tissue engineering. It has been shown that cells can be cultured on most organic biomimetic materials, which now are losing popularity in favour of novel, hybrid systems. In this study, a series of photosensitive sol-gel hybrid materials, based on silicon-zirconium and silicon-titanium oxides, have been investigated for their suitability in three-dimensional scaffold fabrication. These materials can be structured by two-photon polymerization, a laser-based technique allowing the fabrication of micrometre-size structures with submicron resolution. The work presented here examined the effect of the organic/inorganic composition of the materials on cell behaviour and the establishment of a 'cell-culture friendly' environment. This is vital for cell adhesion, growth and differentiation, as the organic part of the material provides the soft matrix for cell growth, whereas the inorganic component gives the mechanical stability and rigidity of the three-dimensional structures. In addition, the use of femtosecond laser structuring permits the fabrication of a wide range of mechanically stable scaffolds of different sizes and shapes to be tested in terms of cell viability, proliferation and orientation.

  11. Design and Evaluation of a Secure Virtual Power Plant.

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, Jay Tillay [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2017-09-01

    For three years, Sandia National Laboratories, Georgia Institute of Technology, and University of Illinois at Urbana-Champaign investigated a smart grid vision in which renewable-centric Virtual Power Plants (VPPs) provided ancillary services with interoperable distributed energy resources (DER). This team researched, designed, built, and evaluated real-time VPP designs incorporating DER forecasting, stochastic optimization, controls, and cyber security to construct a system capable of delivering reliable ancillary services, which have been traditionally provided by large power plants or other dedicated equipment. VPPs have become possible through an evolving landscape of state and national interconnection standards, which now require DER to include grid-support functionality and communications capabilities. This makes it possible for third party aggregators to provide a range of critical grid services such as voltage regulation, frequency regulation, and contingency reserves to grid operators. This paradigm (a) enables renewable energy, demand response, and energy storage to participate in grid operations and provide grid services, (b) improves grid reliability by providing additional operating reserves for utilities, independent system operators (ISOs), and regional transmission organization (RTOs), and (c) removes renewable energy high-penetration barriers by providing services with photovoltaics and wind resources that traditionally were the jobs of thermal generators. Therefore, it is believed VPP deployment will have far-reaching positive consequences for grid operations and may provide a robust pathway to high penetrations of renewables on US power systems. In this report, we design VPPs to provide a range of grid-support services and demonstrate one VPP which simultaneously provides bulk-system energy and ancillary reserves.

  12. Pharmaceutical Cocrystal of Piroxicam: Design, Formulation and Evaluation

    Science.gov (United States)

    Panzade, Prabhakar; Shendarkar, Giridhar; Shaikh, Sarfaraj; Balmukund Rathi, Pavan

    2017-01-01

    Purpose: Cocrystallisation of drug with coformers is a promising approach to alter the solid sate properties of drug substances like solubility and dissolution. The objective of the present work was to prepare, formulate and evaluate the piroxicam cocrystal by screening various coformers. Methods: Cocrystals of piroxicam were prepared by dry grinding method. The melting point and solubility of crystalline phase was determined. The potential cocrystal was characterized by DSC, IR, XRPD. Other pharmaceutical properties like solubility and dissolution rate were also evaluated. Orodispersible tablets of piroxicam cocrystal were formulated, optimized and evaluated using 32 factorial design. Results: Cocrystals of piroxicam-sodium acetate revealed the variation in melting points and solubility. The cocrystals were obtained in 1:1 ratio with sodium acetate. The analysis of Infrared explicitly indicated the shifting of characteristic bands of piroxicam. The X-Ray Powder Diffraction pattern denoted the crystallinity of cocrystals and noteworthy difference in 2θ value of intense peaks. Differential scanning calorimetry spectra of cocrystals indicated altered endotherms corresponding to melting point. The pH solubility profile of piroxicam showed sigmoidal curve, which authenticated the pKa-dependent solubility. Piroxicam cocrystals also exhibited a similar pH-solubility profile. The cocrystals exhibited faster dissolution rate owing to cocrystallization as evident from 30% increase in the extent of dissolution. The orodispersible tablets of piroxicam cocrystals were successfully prepared by direct compression method using crosscarmelose sodium as superdisintegrant with improved disintegration time (30 sec) and dissolution rate. Conclusion: The piroxicam cocrystal with modified properties was prepared with sodium acetate and formulated as orodispersible tablets having faster disintegration and greater dissolution rate. PMID:29071222

  13. Pharmaceutical Cocrystal of Piroxicam: Design, Formulation and Evaluation

    Directory of Open Access Journals (Sweden)

    Prabhakar Panzade

    2017-09-01

    Full Text Available Purpose: Cocrystallisation of drug with coformers is a promising approach to alter the solid sate properties of drug substances like solubility and dissolution. The objective of the present work was to prepare, formulate and evaluate the piroxicam cocrystal by screening various coformers. Methods: Cocrystals of piroxicam were prepared by dry grinding method. The melting point and solubility of crystalline phase was determined. The potential cocrystal was characterized by DSC, IR, XRPD. Other pharmaceutical properties like solubility and dissolution rate were also evaluated. Orodispersible tablets of piroxicam cocrystal were formulated, optimized and evaluated using 32 factorial design. Results: Cocrystals of piroxicam-sodium acetate revealed the variation in melting points and solubility. The cocrystals were obtained in 1:1 ratio with sodium acetate. The analysis of Infrared explicitly indicated the shifting of characteristic bands of piroxicam. The X-Ray Powder Diffraction pattern denoted the crystallinity of cocrystals and noteworthy difference in 2θ value of intense peaks. Differential scanning calorimetry spectra of cocrystals indicated altered endotherms corresponding to melting point. The pH solubility profile of piroxicam showed sigmoidal curve, which authenticated the pKa-dependent solubility. Piroxicam cocrystals also exhibited a similar pH-solubility profile. The cocrystals exhibited faster dissolution rate owing to cocrystallization as evident from 30% increase in the extent of dissolution. The orodispersible tablets of piroxicam cocrystals were successfully prepared by direct compression method using crosscarmelose sodium as superdisintegrant with improved disintegration time (30 sec and dissolution rate.Conclusion: The piroxicam cocrystal with modified properties was prepared with sodium acetate and formulated as orodispersible tablets having faster disintegration and greater dissolution rate.

  14. Design, formulation and evaluation of Aloe vera chewing gum

    Science.gov (United States)

    Aslani, Abolfazl; Ghannadi, Alireza; Raddanipour, Razieh

    2015-01-01

    Background: Aloe vera has antioxidant, antiinflammatory, healing, antiseptic, anticancer and antidiabetic effects. The aim of the present study was to design and evaluate the formulation of Aloe vera chewing gum with an appropriate taste and quality with the indications for healing oral wounds, such as lichen planus, mouth sores caused by cancer chemotherapy and mouth abscesses as well as reducing mouth dryness caused by chemotherapy. Materials and Methods: In Aloe vera powder, the carbohydrate content was determined according to mannose and phenolic compounds in terms of gallic acid. Aloe vera powder, sugar, liquid glucose, glycerin, sweeteners and different flavors were added to the soft gum bases. In Aloe vera chewing gum formulation, 10% of dried Aloe vera extract entered the gum base. Then the chewing gum was cut into pieces of suitable sizes. Weight uniformity, content uniformity, the organoleptic properties evaluation, releasing the active ingredient in the phosphate buffer (pH, 6.8) and taste evaluation were examined by Latin square method. Results: One gram of Aloe vera powder contained 5.16 ± 0.25 mg/g of phenolic compounds and 104.63 ± 4.72 mg/g of carbohydrates. After making 16 Aloe vera chewing gum formulations, the F16 formulation was selected as the best formulation according to its physicochemical and organoleptic properties. In fact F16 formulation has suitable hardness, lack of adhesion to the tooth and appropriate size and taste; and after 30 min, it released more than 90% of its drug content. Conclusion: After assessments made, the F16 formulation with maltitol, aspartame and sugar sweeteners was selected as the best formulation. Among various flavors used, peppermint flavor which had the most acceptance between consumers was selected. PMID:26605214

  15. An investigation of how design managers in organisations in Bahrain manage and evaluate visual communication design for strategic advantage

    OpenAIRE

    Hallak, Lilian Issa Anton

    2015-01-01

    The role of visual communication design continues to increase in importance around the world. In Bahrain, organisations are increasingly considering visual communication design as a means of accomplishing organisational goals. The research aims to understand the process by which design managers in organisations in Bahrain manage and evaluate visual communication designs to gain strategic advantage. Even though the management of visual communication design has not yet been recognised as a ...

  16. Design and evaluation of cellular power converter architectures

    Science.gov (United States)

    Perreault, David John

    Power electronic technology plays an important role in many energy conversion and storage applications, including machine drives, power supplies, frequency changers and UPS systems. Increases in performance and reductions in cost have been achieved through the development of higher performance power semiconductor devices and integrated control devices with increased functionality. Manufacturing techniques, however, have changed little. High power is typically achieved by paralleling multiple die in a sing!e package, producing the physical equivalent of a single large device. Consequently, both the device package and the converter in which the device is used continue to require large, complex mechanical structures, and relatively sophisticated heat transfer systems. An alternative to this approach is the use of a cellular power converter architecture, which is based upon the parallel connection of a large number of quasi-autonomous converters, called cells, each of which is designed for a fraction of the system rating. The cell rating is chosen such that single-die devices in inexpensive packages can be used, and the cell fabricated with an automated assembly process. The use of quasi-autonomous cells means that system performance is not compromised by the failure of a cell. This thesis explores the design of cellular converter architectures with the objective of achieving improvements in performance, reliability, and cost over conventional converter designs. New approaches are developed and experimentally verified for highly distributed control of cellular converters, including methods for ripple cancellation and current-sharing control. The performance of these techniques are quantified, and their dynamics are analyzed. Cell topologies suitable to the cellular architecture are investigated, and their use for systems in the 5-500 kVA range is explored. The design, construction, and experimental evaluation of a 6 kW cellular switched-mode rectifier is also addressed

  17. Design, Construction, and Evaluation of Rubber Friction Tester

    Directory of Open Access Journals (Sweden)

    Mehdi Razzaghi Kashani

    2012-12-01

    Full Text Available Coeffcient of  friction  (COF  for  rubber parts  is one of  the key parameters in their interaction with solid rough surfaces (micrometer to millimeter scales,  such  as  tire-road  interactions. COF  of  rubber  depends  on  viscoelastic properties of rubber, roughness characteristics of the counter-part surface, and process variables such as contact nominal pressure and sliding speed. Due to the need for measuring COF  for  rubber,  a  new  friction  tester, with  continuous  variation  of nominal pressure and sliding speed, was designed and constructed in order to assess the effect of above mentioned parameters. Tire tread compounds, as the most common rubber part  in  the feld of  rubber  tribology, was used  for  this purpose. Viscoelastic properties of compounds were varied by changing composition of styrene-butadiene rubber (SBR and butadiene rubber (BR in the blend. Effect of surface roughness was evaluated by using silicon-carbide papers with different roughness parameters. By statistical analysis it was shown that the designed friction tester has high accuracy in measuring the coeffcient of friction of rubber and differentiating the effective parameters. Increasing the nominal pressure led to reduction of COF and increase in sliding speed forced it through a maximum. In conclusion, the loss factor of the compound and asymmetry in roughness distribution of the counter-surface are considered as the most effective parameters on COF of rubber.

  18. Design and evaluation of representative indoor radon surveys

    International Nuclear Information System (INIS)

    Csige, I.; Csegzi, S.

    2004-01-01

    We have developed a procedure to design and evaluate representative indoor radon surveys. The procedure is based on random sampling of a population of houses and careful statistical analysis of measured indoor radon concentrations. The method is designed to estimate the fraction of houses in which annual average 222 Rn activity concentration may exceed a certain reference level. Measurements of annual average indoor 222 Rn activity concentration were done in sleeping rooms at pillow level using etched track type radon detectors. We applied the above procedure in an old fashioned village and in a fast developing small city in Transylvania, Romania. In the village almost all houses were single floor wooden made houses without cellar built with traditional technology on a geologically uniform area. The distribution of indoor 222 Rn activity concentration in a sample of 115 houses can almost perfectly be fitted with log-normal probability density function. The correlation coefficient of linear fitting on linearized scales was k = -0.9980. The percentages of houses expected to have annual average 222 Rn activity concentration higher than 400 Bq m -3 is less than 1 %, and of those higher than 600 Bq m -3 can be estimated to be around 0.1 %. The small city, on the other hand lies on a geologically inhomogeneous area, and house construction technology has also changed dramatically in past decades. The resulting distribution of measured indoor 222 Rn activity concentration in a sample of 116 houses cannot be fitted with any simple probability density function. Therefore the prediction of the fraction of houses in which the annual average 222 Rn activity concentration may exceed a certain reference level could not be done adequately. With certain assumptions we estimated that the percentages of houses expected to have annual average 222 Rn activity concentration higher than 400 Bq m -3 is between 3 and 7 %, and of those higher than 600 Bq m -3 can be estimated to be between

  19. Design, formulation and evaluation of nicotine chewing gum.

    Science.gov (United States)

    Aslani, Abolfazl; Rafiei, Sahar

    2012-01-01

    Nicotine replacement therapy (NRT) can help smokers to quit smoking. Nicotine chewing gum has attracted the attention from pharmaceutical industries to offer it to consumers as an easily accessible NRT product. However, the bitter taste of such gums may compromise their acceptability by patients. This study was, therefore, designed to develop 2 and 4 mg nicotine chewing gums of pleasant taste, which satisfy the consumers the most. Nicotine, sugar, liquid glucose, glycerin, different sweetening and taste-masking agents, and a flavoring agent were added to the gum bases at appropriate temperature. The medicated gums were cut into pieces of suitable size and coated by acacia aqueous solution (2% w/v), sugar dusting, followed by acacia-sugar-calcium carbonate until a smooth surface was produced. The gums' weight variation and content uniformity were determined. The release of nicotine was studied in pH 6.8 phosphate buffer using a mastication device which simulated the mastication of chewing gum in human. The Latin Square design was used for the evaluation of organoleptic characteristics of the formulations at different stages of development. Most formulations released 79-83% of their nicotine content within 20 min. Nicotine-containing sugar-coated gums in which aspartame as sweetener and cherry and eucalyptus as flavoring agents were incorporated (i.e. formulations F(19-SC) and F(20-SC), respectively) had optimal chewing hardness, adhering to teeth, and plumpness characteristics, as well as the most pleasant taste and highest acceptability to smokers. Taste enhancement of nicotine gums was achieved where formulations comprised aspartame as the sweetener and cherry and eucalyptus as the flavoring agents. Nicotine gums of pleasant taste may, therefore, be used as NRT to assist smokers quit smoking.

  20. Designing and Evaluating an Online Role Play in Conflict Management

    Science.gov (United States)

    Hrastinski, Stefan; Watson, Jason

    2009-01-01

    Purpose: This paper aims to identify, through a literature review, key issues regarding how online role plays can be designed and to apply them when designing a role play on conflict management. Design/methodology/approach: By drawing on the key issues identified in the literature review, a role play on conflict management was designed and…

  1. Design and evaluation of the MAMMI dedicated breast PET

    International Nuclear Information System (INIS)

    Moliner, L.; González, A. J.; Soriano, A.; Sánchez, F.; Correcher, C.; Orero, A.; Carles, M.; Vidal, L. F.; Barberá, J.; Caballero, L.; Seimetz, M.; Vázquez, C.; Benlloch, J. M.

    2012-01-01

    Purpose: A breast dedicated positron emission tomography (PET) scanner has been developed based on monolithic LYSO crystals coupled to position sensitive photomultiplier tubes (PSPMTs). In this study, we describe the design of the PET system and report on its performance evaluation. Methods: MAMMI is a breast PET scanner based on monolithic LYSO crystals. It consists of 12 compact modules with a transaxial field of view (FOV) of 170 mm in diameter and 40 mm axial FOV that translates to cover up to 170 mm. The patient lies down in a prone position that facilitates maximum breast elongation. Quantitative performance analysis of the calculated method for the attenuation correction specifically developed for MAMMI, and based on PET image segmentation, has also been conducted in this evaluation. In order to fully determine the MAMMI prototype's performance, we have adapted the measurements suggested for National Electrical Manufacturers Association (NEMA) NU 2-2007 and NU 4-2008 protocol tests, as they are defined for whole-body and small animal PET scanners, respectively. Results: Spatial resolutions of 1.6, 1.8, and 1.9 mm were measured in the axial, radial, and tangential directions, respectively. A scatter fraction of 20.8% was obtained and the maximum NEC was determined to be 25 kcps at 44 MBq. The average sensitivity of the system was observed to be 1% for an energy window of (250 keV–750 keV) and a maximum absolute sensitivity of 1.8% was measured at the FOV center. Conclusions: The overall performance of the MAMMI reported on this evaluation quantifies its ability to produce high quality PET images. Spatial resolution values below 3 mm were measured in most of the FOV. Only the radial component of spatial resolution exceeds the 3 mm at radial positions larger than 60 mm. This study emphasizes the need for standardized testing methodologies for dedicated breast PET systems similar to NEMA standards for whole-body and small animal PET scanners.

  2. BWR power oscillation evaluation methodologies in core design

    International Nuclear Information System (INIS)

    Hotta, Akitoshi

    1995-01-01

    At the initial stage of BWR development, the power oscillation due to the nuclear-thermal interaction originated in random boiling phenomena and nuclear void feedback was feared. But it was shown that under the high pressure condition in the normal operation of recent commercial BWRs, the core is in very stable state. However, power oscillation events have been observed in actual machines, and it is necessary to do the stability evaluation that sufficiently reflects the detailed operation conditions of actual plants. As the cause of power oscillation events, the instability of control system and nuclear-thermal coupling instability are important, and their mechanisms are explained. As the model for analyzing the stability of BWR core, the nuclear-thermal coupling model in frequency domain is the central existence. As the information for the design, the parameters of fuel assemblies, and the nuclear parameters and the thermohydraulic parameters of cores are enumerated. LAPUR-TSI is a nuclear-thermal coupling model. The analysis system in the software of Tokyo Electric Power Co. is outlined, and the analysis model was verified. (K.I.)

  3. Design, Construction and Evaluation of Wild Pistachio Sheller

    Directory of Open Access Journals (Sweden)

    F Karimi

    2014-09-01

    Full Text Available The wild pistachio (Pistacia Atlantica Mutika exists in 2.4 million hectares of Iranian forest. In spite of high nutritional and medical value of this fruit, its use and processing are still performed manually. The objectives of this research are to design, to construct and to evaluate the performance of a pistachio hulling machine. The pistachio of Kerman province was chosen as the case of study. The mechanism of shelling was chosen based on the applied pressure force of two cylinders, driving and driven. The effects of input variables including revolution of driving cylinder (three levels, the gap between two cylinders (four levels and moisture content (four levels on the performance of machine (shelling efficiency, percentage of intact kernel, percentage of imperfective broken nut, percentage of dust, and percentage of unshelled nut were analyzed. The results showed that the shelling efficiency decreases with increasing the gap of two cylinders and moisture content of wild pistachio. The maximum intact kernel was obtained at moisture content of 6.61 wb %. The best performance was observed with the following conditions: the cylinders’ gap of 0.48 mm, rotational speed of the driving cylinder of 25.84 rpm and moisture content of 4.31% w.b.

  4. Design and evaluation of nicorandil extended-release tablet

    Directory of Open Access Journals (Sweden)

    Ju-Young Kim

    2015-04-01

    Full Text Available The aim of this study was to design and evaluate extended-release formulations of a model drug, nicorandil, in order to achieve the desired steady-state plasma concentration of drug in vivo. Simulation was employed to estimate optimum dissolution and absorption rate of nicorandil. The dissolution test was employed using pH 1.2, 4.0, 6.8 buffer solution, or water, to measure the in vitro release behaviors of nicorandil formulations. A single dose (15 mg of each formulation was orally administered to four beagle dogs under fasted conditions, and the pharmacokinetic parameters were calculated. The in vitro/in vivo relationship of the extended-release formulation was confirmed using in vitro dissolution profiles and plasma concentrations of drug in beagle dogs. Nicorandil was released completely within 30 min from the immediate-release tablets and released for 24 h from the extended-release tablets. The nicorandil plasma concentration could be modified by adjusting the drug release rate from the extended-release formulation. The release rate of nicorandil was the rate-limiting step in the overall absorption of drug from the extended-release formulations. These results highlight the potential of a nicorandil extended-release formulation in the treatment of angina pectoris.

  5. Development of panel loudspeaker system: design, evaluation and enhancement.

    Science.gov (United States)

    Bai, M R; Huang, T

    2001-06-01

    Panel speakers are investigated in terms of structural vibration and acoustic radiation. A panel speaker primarily consists of a panel and an inertia exciter. Contrary to conventional speakers, flexural resonance is encouraged such that the panel vibrates as randomly as possible. Simulation tools are developed to facilitate system integration of panel speakers. In particular, electro-mechanical analogy, finite element analysis, and fast Fourier transform are employed to predict panel vibration and the acoustic radiation. Design procedures are also summarized. In order to compare the panel speakers with the conventional speakers, experimental investigations were undertaken to evaluate frequency response, directional response, sensitivity, efficiency, and harmonic distortion of both speakers. The results revealed that the panel speakers suffered from a problem of sensitivity and efficiency. To alleviate the problem, a woofer using electronic compensation based on H2 model matching principle is utilized to supplement the bass response. As indicated in the result, significant improvement over the panel speaker alone was achieved by using the combined panel-woofer system.

  6. Societal risk approach to safeguards design and evaluation

    International Nuclear Information System (INIS)

    Bennett, C.A.; Murphey, W.M.; Sherr, T.S.

    1975-06-01

    There has been much discussion and public debate concerning the effectiveness of the national system of safeguards against malevolent acts involving nuclear materials. Useful dialogue on this subject has been hampered by the lack of well-defined objectives, system parameters and boundary conditions as a framework for communication. This study provides such a framework. Expressing the safeguards objective in terms of societal risk represents a change in focus, rather than intent, from the earlier view of safeguards as a system for protecting nuclear material against theft or diversion. The study defines both the safeguards problem and the safeguards system in terms that can be related to the general safeguards objective. It is axiomatic that the first step to an effective solution is a careful definition of the problem. The significant and immediate value of this study lies in the rigorous definition and systematic organization of recognized elements into a coherent and comprehensive pattern. Although the title specifically addresses design and evaluation, the framework provided by the study will be a useful management tool for safeguards implementation and administration as well. (U.S.)

  7. Design Methodology and Performance Evaluation of New Generation Sounding Rockets

    Directory of Open Access Journals (Sweden)

    Marco Pallone

    2018-01-01

    Full Text Available Sounding rockets are currently deployed for the purpose of providing experimental data of the upper atmosphere, as well as for microgravity experiments. This work provides a methodology in order to design, model, and evaluate the performance of new sounding rockets. A general configuration composed of a rocket with four canards and four tail wings is sized and optimized, assuming different payload masses and microgravity durations. The aerodynamic forces are modeled with high fidelity using the interpolation of available data. Three different guidance algorithms are used for the trajectory integration: constant attitude, near radial, and sun-pointing. The sun-pointing guidance is used to obtain the best microgravity performance while maintaining a specified attitude with respect to the sun, allowing for experiments which are temperature sensitive. Near radial guidance has instead the main purpose of reaching high altitudes, thus maximizing the microgravity duration. The results prove that the methodology at hand is straightforward to implement and capable of providing satisfactory performance in term of microgravity duration.

  8. Design and Evaluation of a Cross-Cultural Training System

    Science.gov (United States)

    Santarelli, Thomas; Stagl, Kevin C.

    2011-01-01

    Cross-cultural competency, and the underlying communication and affective skills required to develop such expertise, is becoming increasingly important for a wide variety of domains. To address this need, we developed a blended learning platform which combines virtual role-play with tutorials, assessment and feedback. A Middle-Eastern Curriculum (MEC) exemplar for cross-cultural training U.S. military personnel was developed to guide the refinement of an existing game-based training platform. To complement this curriculum, we developed scenario authoring tools to enable end-users to define training objectives, link performance measures and feedback/remediation to these objectives, and deploy experiential scenarios within a game-based virtual environment (VE). Lessons learned from the design and development of this exemplar cross-cultural competency curriculum, as well as formative evaluation results, are discussed. Initial findings suggest that the underlying training technology promotes deep levels of semantic processing of the key information of relevant cultural and communication skills.

  9. Innovative Design and Performance Evaluation of Bionic Imprinting Toothed Wheel.

    Science.gov (United States)

    Zhang, Zhihong; Wang, Xiaoyang; Tong, Jin; Stephen, Carr

    2018-01-01

    A highly efficient soil-burrowing dung beetle possesses an intricate outer contour curve on its foreleg end-tooth. This study was carried out based on evidence that this special outer contour curve has the potential of reducing soil penetration resistance and could enhance soil-burrowing efficiency. A toothed wheel is a typical agricultural implement for soil imprinting, to increase its working efficiency; the approach of the bionic geometrical structure was utilized to optimize the innovative shape of imprinting toothed wheel. Characteristics in the dung beetle's foreleg end-tooth were extracted and studied by the edge detection technique. Then, this special outer contour curve was modeled by a nine-order polynomial function and used for the innovative design of imprinting the tooth's cutting edge. Both the conventional and bionic teeth were manufactured, and traction tests in a soil bin were conducted. Taking required draft force and volume of imprinted microbasin as the evaluating indexes, operating efficiency and quality of different toothed wheels were compared and investigated. Results indicate that compared with the conventional toothed wheel, a bionic toothed wheel possesses a better forward resistance reduction property against soil and, meanwhile, can enhance the quality of soil imprinting by increasing the volume of the created micro-basin.

  10. EVALUATION OF STREET FURNITURE ACCORDING TO BASIC DESIGN PRINCIPLES

    OpenAIRE

    GHORAB, Peyman; YÜCEL CAYMAZ, Gökçen Firdevs

    2014-01-01

    In the urban context, it is important to create more comfortable and livable environments with proper planning, design and application. Because aesthetic considerations are of more importance today, designing urban furniture to give a more beautiful appearance to cities is of high priority; designers and those working in related disciplines must be careful to observe these principles throughout the design process. This paper describes research conducted to review the aesthetic principles invo...

  11. Collaborative design in education : evaluation of three approaches

    NARCIS (Netherlands)

    Leeuwen, van J.P.; Gassel, van F.J.M.; Otter, den A.F.H.J.; Duarte, J.P.; Sampaio, A.Z.

    2005-01-01

    Collaboration in design can take place in a physical, social space, in a distributed or virtual environment, or in a combination of both. Design teams use a range of ICT means to support both synchronous and asynchronous communication. While these tools are designed to facilitate collaboration, the

  12. Evaluation of vertical profiles to design continuous descent approach procedure

    Science.gov (United States)

    Pradeep, Priyank

    The current research focuses on predictability, variability and operational feasibility aspect of Continuous Descent Approach (CDA), which is among the key concepts of the Next Generation Air Transportation System (NextGen). The idle-thrust CDA is a fuel economical, noise and emission abatement procedure, but requires increased separation to accommodate for variability and uncertainties in vertical and speed profiles of arriving aircraft. Although a considerable amount of researches have been devoted to the estimation of potential benefits of the CDA, only few have attempted to explain the predictability, variability and operational feasibility aspect of CDA. The analytical equations derived using flight dynamics and Base of Aircraft and Data (BADA) Total Energy Model (TEM) in this research gives insight into dependency of vertical profile of CDA on various factors like wind speed and gradient, weight, aircraft type and configuration, thrust settings, atmospheric factors (deviation from ISA (DISA), pressure and density of the air) and descent speed profile. Application of the derived equations to idle-thrust CDA gives an insight into sensitivity of its vertical profile to multiple factors. This suggests fixed geometric flight path angle (FPA) CDA has higher degree of predictability and lesser variability at the cost of non-idle and low thrust engine settings. However, with optimized design this impact can be overall minimized. The CDA simulations were performed using Future ATM Concept Evaluation Tool (FACET) based on radar-track and aircraft type data (BADA) of the real air-traffic to some of the busiest airports in the USA (ATL, SFO and New York Metroplex (JFK, EWR and LGA)). The statistical analysis of the vertical profiles of CDA shows 1) mean geometric FPAs derived from various simulated vertical profiles are consistently shallower than 3° glideslope angle and 2) high level of variability in vertical profiles of idle-thrust CDA even in absence of

  13. Design of subjects training on reactor simulator and feasibility study - toward the empirical evaluation of interface design concept

    International Nuclear Information System (INIS)

    Yamaguchi, Y.; Furukawa, H.; Tanabe, F.

    1998-01-01

    On-going JAERI's project for empirical evaluation of the ecological interface design concept was first described. The empirical evaluation is planned to be proceeded through three consecutive steps; designing and actual implementation of the interface on reactor simulator, verification of the interface created, and the validation by the simulator experiment. For conducting the project, three different experimental resources are prerequisite, that are, data analysis method for identifying the operator's strategies, experimental facility including reactor simulator, and experimental subjects or subjects training method. Among the three experimental resources, subjects training method was recently designed and a simulator experiment was earned out in order to examine the feasibility of the designed training method. From the experiment and analysis of the experimental records, we could conclude that it is feasible that the experimental subjects having an appropriate technical basis can gain the sufficient competence for evaluation work of the interface design concept by using the training method designed. (author)

  14. Design and evaluation of materials for space reactors

    International Nuclear Information System (INIS)

    Tavassoli, A.A.; Vrillon, B.; Robert, G.

    1990-01-01

    The French programme envisages a 20 kWe reactor, project ERATO, with three technological options. The first option is a sodium cooled reactor, derived from the fast breeder reactor technology, (upper core outlet temperature of 700 0 C). The second option is based on the High Temperature Gas-cooled Reactor technology (outlet temperature range 700 0 C-900 0 C). The third option is the reference solution, lithium cooled and UN fuelled fast spectrum reactor, (outlet temperature as high as 1200 0 C). The choice is essentially dominated by material considerations, and more specifically by the problems related to the compatibility with the cooling medium and to the high temperature creep resistance. For the first system limited work will be needed as the technology used is well experimented and there is a wealth of information on the austenitic stainless steel Type 316L-SPH. For the second system, most of the work has been concentrated on characterization of existing commercial alloys. This has included the preselection and the testing of a number of superalloys irradiated or not. The results obtained from high temperature tensile and creep tests have allowed selection of Haynes 230 as the primary candidate material and have also permitted calculation of allowable design stresses for this alloy. For the very high temperature system the French R and D programme has focused on Mo-Re alloys. The results obtained to this date from microstructural examinations and mechanical tests performed on different alloy compositions have allowed selection of Mo-25%Re for future optimization work. They have also shown the need for evaluation of creep properties at low stresses where microstructural instabilities are likely to occur as a result of long exposure to high temperature

  15. Investigating the Design Process

    DEFF Research Database (Denmark)

    Kautz, Karlheinz

    2011-01-01

    Purpose – This paper aims to explore a case of customer and user participation in an agile software development project, which produced a tailor-made information system for workplace support as a step towards a theory of participatory design in agile software development. Design....../methodology/approach – Based on an integrated framework for user participation derived from the participatory design literature the research was performed as a case study and semi-structured, open-ended interviews were conducted with about a third of the development team and with a representative sample of key players...... and with functional and democratic empowerment. The onsite customers played informative, consultative and participative roles. The analysis revealed that planning games, user stories and story cards, working software and acceptance tests structured the customer and user participation. This form of user participation...

  16. A Design for the Evaluation of Management Information Systems.

    Science.gov (United States)

    Spuck, Dennis W.; Bozeman, William C.

    1980-01-01

    This paper has presented a model for the evaluation of management information systems. The three levels of information considered were actual, perceptual, and attitudinal. The dimensions of evaluation discussed were function, utilization, and effects. (Author/IRT)

  17. Reliability Evaluation and Probabilistic Design of Coastal Structures

    DEFF Research Database (Denmark)

    Burcharth, H. F.

    1993-01-01

    Conventional design practice for coastal structures is deterministic in nature and is based on the concept of a design load, which should not exceed the resistance (carrying capacity) of the structure. The design load is usually defined on a probabilistic basis as a characteristic value of the load......, e.g. the expectation (mean) value of the lOO-year return period event, however, often without consideration of the involved uncertainties. The resistance is in most cases defined in terms of the load which causes a certain design impact or damage to the structure and is not given as an ultimate...... force or deformation. This is because most of the available design formulae only give the relationship between wave characteristics and structural response, e.g. in terms of run-up, overtopping, armour layer damage etc. An example is the Hudson formula for armour layer stability. Almost all such design...

  18. Mission Trade Space Evaluation through Multiphysics Design and Optimization

    Data.gov (United States)

    National Aeronautics and Space Administration — In recent years, modeling and simulation tools have enabled engineers to design highly complex systems while taking into consideration constraints across multiple...

  19. DOE (Department of Energy) natural phenomena guidelines flood design and evaluation

    International Nuclear Information System (INIS)

    McCann, M.W.; Savy, J.B.

    1989-01-01

    Design and evaluation guidelines for DOE (Department of Energy) facilities subjected to earthquake, wind/tornado, and flood have been developed and presented in UCRL-15910 (Ref.1). This paper summarizes Chapter 6 of UCRL-15910 describing the philosophy and procedures for the design or evaluation of facilities for flood. The flood design and evaluation guidelines seek to ensure that DOE facilities satisfy the performance goals described in UCRL-15910. The guidelines are applicable to new and existing construction; however, in the evaluation of existing facilities, fewer design options may be available to satisfy the performance goals. Evaluation of the flood design for a facility consists of: (1) defining the design basis flood (DBFL), (2) evaluating site conditions (e.g., facility location, location of openings and doorways), and (3) assessing flood design strategies (e.g., build above DBFL levels, harden the site)

  20. Comparative Ergonomic Evaluation of Spacesuit and Space Vehicle Design

    Science.gov (United States)

    England, Scott; Cowley, Matthew; Benson, Elizabeth; Harvill, Lauren; Blackledge, Christopher; Perez, Esau; Rajulu, Sudhakar

    2012-01-01

    With the advent of the latest human spaceflight objectives, a series of prototype architectures for a new launch and reentry spacesuit that would be suited to the new mission goals. Four prototype suits were evaluated to compare their performance and enable the selection of the preferred suit components and designs. A consolidated approach to testing was taken: concurrently collecting suit mobility data, seat-suit-vehicle interface clearances, and qualitative assessments of suit performance within the volume of a Multi-Purpose Crew Vehicle mockup. It was necessary to maintain high fidelity in a mockup and use advanced motion-capture technologies in order to achieve the objectives of the study. These seemingly mutually exclusive goals were accommodated with the construction of an optically transparent and fully adjustable frame mockup. The construction of the mockup was such that it could be dimensionally validated rapidly with the motioncapture system. This paper describes the method used to create a space vehicle mockup compatible with use of an optical motion-capture system, the consolidated approach for evaluating spacesuits in action, and a way to use the complex data set resulting from a limited number of test subjects to generate hardware requirements for an entire population. Kinematics, hardware clearance, anthropometry (suited and unsuited), and subjective feedback data were recorded on 15 unsuited and 5 suited subjects. Unsuited subjects were selected chiefly based on their anthropometry in an attempt to find subjects who fell within predefined criteria for medium male, large male, and small female subjects. The suited subjects were selected as a subset of the unsuited medium male subjects and were tested in both unpressurized and pressurized conditions. The prototype spacesuits were each fabricated in a single size to accommodate an approximately average-sized male, so select findings from the suit testing were systematically extrapolated to the extremes

  1. Coal gasification systems engineering and analysis. Appendix G: Commercial design and technology evaluation

    Science.gov (United States)

    1980-01-01

    A technology evaluation of five coal gasifier systems (Koppers-Totzek, Texaco, Babcock and Wilcox, Lurgi and BGC/Lurgi) and procedures and criteria for evaluating competitive commercial coal gasification designs is presented. The technology evaluation is based upon the plant designs and cost estimates developed by the BDM-Mittelhauser team.

  2. Design and evaluation of a new exoskeleton for gait rehabilitation

    Directory of Open Access Journals (Sweden)

    I. D. Geonea

    2017-10-01

    Full Text Available This work addresses the design and numerical characterization of a new exoskeleton solution for human leg motion assistance and rehabilitation. The exoskeleton solution is anthropomorphic, simple, low cost and easy to adapt on the human subject. The design aspect concerns the exoskeleton mechatronic structure, achieved in SolidWorks virtual environment. Numerical simulation is performed in MSC.ADAMS simulation environment. Obtained results for the exoskeleton computed motion are compared with those obtained from experimental walking of healthy subject. The prototype feasibility is studied both for design and operation aspect.

  3. COMPARISON OF EXPERIMENTAL-DESIGNS COMBINING PROCESS AND MIXTURE VARIABLES .1. DESIGN CONSTRUCTION AND THEORETICAL EVALUATION

    NARCIS (Netherlands)

    DUINEVELD, CAA; SMILDE, AK; DOORNBOS, DA

    The combination of process variables and mixture variables in experimental design is a problem which has not yet been solved. It is examined here whether a set of designs can be found which can be used for a series of models of reasonable complexity. The proposed designs are compared with known

  4. COMPARISON OF EXPERIMENTAL-DESIGNS COMBINING PROCESS AND MIXTURE VARIABLES .1. DESIGN CONSTRUCTION AND THEORETICAL EVALUATION

    NARCIS (Netherlands)

    DUINEVELD, C. A. A.; Smilde, A. K.; Doornbos, D. A.

    1993-01-01

    The combination of process variables and mixture variables in experimental design is a problem which has not yet been solved. It is examined here whether a set of designs can be found which can be used for a series of models of reasonable complexity. The proposed designs are compared with known

  5. 47 CFR 7.7 - Product design, development, and evaluation.

    Science.gov (United States)

    2010-10-01

    ...: (1) Where market research is undertaken, including individuals with disabilities in target populations of such research; (2) Where product design, testing, pilot demonstrations, and product trials are... access solutions through testing with individuals with disabilities or with appropriate disability...

  6. design, construction and performance evaluation of multiple casting

    African Journals Online (AJOL)

    eobe

    time taken for solidification, plays an important role in the casting. There should not ... Keywords: Design, Construction, Multiple casting machine, Compo Casting operation. 1. Introduction .... metal and pathway channel pipe with heater is used.

  7. design, construction and evaluation of a vertical plate maize seed ...

    African Journals Online (AJOL)

    user

    flow types do not meter individual seeds but rather a consistent volume of .... furrow opener design was mild steel angle iron of ... and required strength and reliability and readily available ..... Bharat, M. R. and Sidharth, D., "Tire modelling.

  8. Lagoa Real design. Description and evaluation of sampling system

    International Nuclear Information System (INIS)

    Hashizume, B.K.

    1982-10-01

    This report describes the samples preparation system of drilling from Lagoa Real Design, aiming obtainment representative fraction of the half from drilling outlier. The error of sampling + analysis and analytical accuracy was obtainment by delayed neutron analysis. (author)

  9. Design, fabrication and evaluation of fish meal pelletizing machine ...

    African Journals Online (AJOL)

    A 113.1kg/h fish meal pellet processing machine which produced 4mm diameter pellet, with an average length of 6mm was designed and fabricated. Design values of 210 was used for the maximum angle that the hopper wall formed with the vertical in the discharge zone, a critical stress of 1.3kPa of the ground particulate ...

  10. Design and Operation of the Transformed National Healthy Start Evaluation.

    Science.gov (United States)

    Banks, Jamelle E; Dwyer, Maura; Hirai, Ashley; Ghandour, Reem M; Atrash, Hani K

    2017-12-01

    Purpose Improving pregnancy outcomes for women and children is one of the nation's top priorities. The Healthy Start (HS) program was created to address factors that contribute to high infant mortality rates (IMRs) and persistent disparities in IMRs. The program began in 1991 and was transformed in 2014 to apply lessons from emerging research, past evaluation findings, and expert recommendations. To understand the implementation and impact of the transformed program, there is a need for a robust and comprehensive evaluation. Description The national HS evaluation will include an implementation evaluation, which will describe program components that affect outcomes; a utilization evaluation, which will examine the characteristics of women and infants who did and did not utilize the program; and an outcome evaluation, which will assess the program's effectiveness with regard to producing expected outcomes among the target population. Data sources include the National HS Program Survey, a HS participant survey, and individual-level program data linked to vital records and the Pregnancy Risk Assessment Monitoring System (PRAMS) survey. Assessment Descriptive analyses will be used to examine differences in risk profiles between participants and non-participants, as well as to calculate penetration rates for high-risk women in respective service areas. Multivariable analyses will be used to determine the impact of the program on key outcomes and will explore variation by dose, type of services received, and grantee characteristics. Conclusion Evaluation findings are expected to inform program decisions and direction, including identification of effective program components that can be spread and scaled.

  11. Integrated Computer-aided Framework for Sustainable Chemical Product Design and Evaluation

    DEFF Research Database (Denmark)

    Kalakul, Sawitree; Cignitti, Stefano; Zhang, Lei

    2016-01-01

    This work proposes an integrated model-based framework for chemical product design and evaluation based on which the software, VPPD-Lab (The Virtual Product-Process Design Laboratory) has been developed. The framework allows the following options: (1) design a product using design templates...

  12. Sampling and energy evaluation challenges in ligand binding protein design.

    Science.gov (United States)

    Dou, Jiayi; Doyle, Lindsey; Jr Greisen, Per; Schena, Alberto; Park, Hahnbeom; Johnsson, Kai; Stoddard, Barry L; Baker, David

    2017-12-01

    The steroid hormone 17α-hydroxylprogesterone (17-OHP) is a biomarker for congenital adrenal hyperplasia and hence there is considerable interest in development of sensors for this compound. We used computational protein design to generate protein models with binding sites for 17-OHP containing an extended, nonpolar, shape-complementary binding pocket for the four-ring core of the compound, and hydrogen bonding residues at the base of the pocket to interact with carbonyl and hydroxyl groups at the more polar end of the ligand. Eight of 16 designed proteins experimentally tested bind 17-OHP with micromolar affinity. A co-crystal structure of one of the designs revealed that 17-OHP is rotated 180° around a pseudo-two-fold axis in the compound and displays multiple binding modes within the pocket, while still interacting with all of the designed residues in the engineered site. Subsequent rounds of mutagenesis and binding selection improved the ligand affinity to nanomolar range, while appearing to constrain the ligand to a single bound conformation that maintains the same "flipped" orientation relative to the original design. We trace the discrepancy in the design calculations to two sources: first, a failure to model subtle backbone changes which alter the distribution of sidechain rotameric states and second, an underestimation of the energetic cost of desolvating the carbonyl and hydroxyl groups of the ligand. The difference between design model and crystal structure thus arises from both sampling limitations and energy function inaccuracies that are exacerbated by the near two-fold symmetry of the molecule. © 2017 The Authors Protein Science published by Wiley Periodicals, Inc. on behalf of The Protein Society.

  13. Work-Centered Design and Evaluation of a C2 Visualization Aid

    National Research Council Canada - National Science Library

    Roth, Emilie; Scott, Ronald; Kazmierczak, Tom; Whitaker, Randall; Stilson, Mona; Thomas-Meyers, Gina; Wampler, Jeffrey

    2006-01-01

    .... We have been developing and applying work-centered design and evaluation methodologies to design advanced visualization and support tools intended to more effectively support C2 cognitive and collaborative work...

  14. Experimental Evaluation of Three Designs of Electrodynamic Flexural Transducers

    Directory of Open Access Journals (Sweden)

    Tobias J. R. Eriksson

    2016-08-01

    Full Text Available Three designs for electrodynamic flexural transducers (EDFT for air-coupled ultrasonics are presented and compared. An all-metal housing was used for robustness, which makes the designs more suitable for industrial applications. The housing is designed such that there is a thin metal plate at the front, with a fundamental flexural vibration mode at ∼50 kHz. By using a flexural resonance mode, good coupling to the load medium was achieved without the use of matching layers. The front radiating plate is actuated electrodynamically by a spiral coil inside the transducer, which produces an induced magnetic field when an AC current is applied to it. The transducers operate without the use of piezoelectric materials, which can simplify manufacturing and prolong the lifetime of the transducers, as well as open up possibilities for high-temperature applications. The results show that different designs perform best for the generation and reception of ultrasound. All three designs produced large acoustic pressure outputs, with a recorded sound pressure level (SPL above 120 dB at a 40 cm distance from the highest output transducer. The sensitivity of the transducers was low, however, with single shot signal-to-noise ratio ( SNR ≃ 15 dB in transmit–receive mode, with transmitter and receiver 40 cm apart.

  15. How Store Design Affect the Consumer Evaluation of Fashion Items

    DEFF Research Database (Denmark)

    Münster, Mia Borch; Kristensen, Tore; Gabrielsen, Gorm

    specially designed to match the style of each sub-brand. The interiors of the three shops are analysed and compared. To study the individual responses, data were collected on an iPad using a method building on paired comparisons. The experiment shows how 40 participants rate six products in three different...... shops, and in some cases the study of the room and the product made a surprising match. The results show that the products were not rated higher when presented in the interior designed for the specific sub-brand. However, when looking at the favourite products of the participants, it turned out...... that the majority of the highly rated products were given in one specific room, which does simply that the interior design influenced the consumers when rating their favourite products....

  16. Operator model-based design and evaluation of advanced systems

    International Nuclear Information System (INIS)

    Schryver, J.C.

    1988-01-01

    A multi-level operator modeling approach is recommended to provide broad support for the integrated design of advanced control and protection systems for new nuclear power plants. Preliminary design should address the symbiosis of automated systems and human operator by giving careful attention to the roles assigned to these two system elements. A conceptual model of the operator role is developed in the context of a command control-communication problem. According to this approach, joint responsibility can be realized in at least two ways: sharing or allocation. The inherent stabilities of different regions of the operator role space are considered

  17. Fatigue data compilation and evaluation of fatigue on design

    International Nuclear Information System (INIS)

    Nyilas, A.

    1985-05-01

    The aim of this report is a review of the available fatigue data of various materials necessary for the design of large superconducting magnets for fusion. One of the primary objectives of this work is to present a broad outline of the low temperature fatigue data of relevant materials within the scope of available data. Besides the classical fatigue data of materials the fatigue crack propagation measurements are outlined widely. The existing recommendations for the design of cryogenic structures are described. A brief introduction of fracture mechanics as well as a historical background of the development of our present day understanding of fatigue has been done. (orig.) [de

  18. 36 CFR 1193.23 - Product design, development, and evaluation.

    Science.gov (United States)

    2010-07-01

    ... following factors, as the manufacturer deems appropriate: (1) Where market research is undertaken, including individuals with disabilities in target populations of such research; (2) Where product design, testing, pilot... to validate any unproven access solutions through testing with individuals with disabilities or with...

  19. 47 CFR 6.7 - Product design, development, and evaluation.

    Science.gov (United States)

    2010-10-01

    ... factors, as the manufacturer deems appropriate: (1) Where market research is undertaken, including individuals with disabilities in target populations of such research; (2) Where product design, testing, pilot... to validate any unproven access solutions through testing with individuals with disabilities or with...

  20. Evaluation of Standard Concepts Design of Library Interior Physical Environment

    Directory of Open Access Journals (Sweden)

    Debri Harindya Putri

    2018-01-01

    Full Text Available Currently the function of a room is not only used as a shelter, the function of the room itself to be increased as a refreshing or relaxation area for users to follow the development of creativity and technology in the field of design. The comfortable factor becomes the main factor that indicates a successful process of creating a space. No exception library. The nature of library seemed stiff because of its function as a place to read, now can be developed and made into more dynamic with the special design concepts or color patterns used. Libraries can be created a special concept that suits the characteristics of the users themselves. Most users of the library, especially in college libraries are teenagers. Naturally, teenagers like to gather with their friends and we have to facilitate this activity in our library design concept. In addition we can also determine the needs of users through research by questionnaire method. The answers of users can be mapped and drawn conclusions. To explore the research, the author reviewed some literature about library interior design and observed the library of Ma Chung University as a case study. The combined results of the method can be concluded and the discovery of ideal standards of physical environment. So, the library can be made as a comfortable reading environment so as to increased interest in reading behavior and the frequent visits of students in the library

  1. Probabilistic Evaluation of Eurocode 5 Fire Design Criteria of a ...

    African Journals Online (AJOL)

    Structural reliability analysis for a three-hinge timber portal frame subjected to fire was undertaken. Eight modes of failure were identified for the frame and limit state function was formulated for each failure mode. The limit state functions were based on the Eurocode 5 design criteria. Uncertainties in the timber material ...

  2. Internet information triangulation: Design theory and prototype evaluation

    NARCIS (Netherlands)

    Wijnhoven, Alphonsus B.J.M.; Brinkhuis, Michel

    2014-01-01

    Many discussions exist regarding the credibility of information on the Internet. Similar discussions happen on the interpretation of social scientific research data, for which information triangulation has been proposed as a useful method. In this article, we explore a design theory—consisting of a

  3. Design and evaluation of a heat recuperator for steel slags

    International Nuclear Information System (INIS)

    Gutiérrez Trashorras, Antonio J.; Álvarez, Eduardo Álvarez; Río González, José Luis; Suarez Cuesta, José Manuel; Bernat, Jorge Xiberta

    2013-01-01

    New techniques for emissions reduction and energy efficiency are important challenges of the steel industry. Although great advantages have been reached in these fields, there are still new opportunities. One of them is the possible development of systems to recover energy from slags. The recent policies that encourage the use of renewable and alternative energies determine a favorable scenario for the development of new techniques of heat recovering. In this context, this article presents a new heat recuperation system for the slags produced in the factories of Arcelor–Mittal in Asturias (Spain) and study in detail the design of an innovative slags heat exchanger. To adjust its performance and to determine the influence of the geometric and flow design parameters, the heat exchanger has been simulated using numerical analysis software (CFD). -- Highlights: • A new design of a heat recuperator for slags energy recovery is presented. • The effects of the design parameters have been studied with a numerical model. • Refractory materials with high thermal conductivity improve heat recuperation

  4. Evaluation of j-turn intersection design performance in Missouri.

    Science.gov (United States)

    2013-12-01

    Research shows that a high percentage of crashes that take place on high-speed rural expressways occur at intersections with : minor roads. One low-cost alternative design for improving the safety of at-grade intersections on such expressways is the ...

  5. Design and performance evaluation of very thin overlays in Texas.

    Science.gov (United States)

    2009-06-01

    Very thin overlays 1-inch thick or less were placed as surface layers on five major highways in Texas. : These mixes were designed in the laboratory to have a balance of good rut resistance as measured by : TxDOTs Hamburg Wheel Tracking test and g...

  6. Structural higher education reform - design and evaluation: synthesis report

    NARCIS (Netherlands)

    File, Jonathan M.; Huisman, Jeroen; de Boer, Harry F.; Seeber, Marco; Vukasovic, Martina; Westerheijden, Donald F.

    2016-01-01

    This study analyses how different types of system-level (or ‘landscape’) structural reforms in higher education have been designed and implemented in selected higher education systems. In the 12 case studies that form the core of the project, the researchers examine reforms aimed at: - Increasing

  7. Large scale solar district heating. Evaluation, modelling and designing - Appendices

    Energy Technology Data Exchange (ETDEWEB)

    Heller, A.

    2000-07-01

    The appendices present the following: A) Cad-drawing of the Marstal CSHP design. B) Key values - large-scale solar heating in Denmark. C) Monitoring - a system description. D) WMO-classification of pyranometers (solarimeters). E) The computer simulation model in TRNSYS. F) Selected papers from the author. (EHS)

  8. Risk allocation approach to reactor safety design and evaluation

    International Nuclear Information System (INIS)

    Gokcek, O.; Temme, M.I.; Derby, S.L.

    1978-01-01

    This paper describes a risk allocation technique used for determining nuclear power plant design reliability requirements. The concept of risk allocation-optimum choice of safety function reliabilities under a maximum risk constraint - is described. An example of risk allocation is presented to demonstrate the application of the methodology

  9. Use of workplace evaluations in briefing and design

    NARCIS (Netherlands)

    van der Voordt, Theo; Haugen, Tore I.; Moum, Anita; Brochner, Jan

    2006-01-01

    Many organizations are engaged in organizational change, adopting new management styles and new ways of working. Innovative workplace design is used to facilitate organizational change, to improve user satisfaction and labour productivity, and to lower facility costs. Although some research has been

  10. Automatic evaluation of task-focused parallel jaw gripper design

    DEFF Research Database (Denmark)

    Wolniakowski, Adam; Miatliuk, Konstantsin; Krüger, Norbert

    2014-01-01

    In this paper, we suggest gripper quality metrics that indicate the performance of a gripper given an object CAD model and a task description. Those, we argue, can be used in the design and selection of an appropriate gripper when the task is known. We present three different gripper metrics that...

  11. Design and evaluation of steel bridges with double composite action

    Science.gov (United States)

    2010-02-01

    This report presents findings from a cooperative USF/URS/FDOT research study undertaken to develop design rules for : double composite steel bridges. In the study, a 48 ft long, 16 ft wide, 4 ft. 10 in. deep trapezoidal HPS 70W box section : desig...

  12. Design, synthesis and bioactivity evaluation of tribactam beta lactamase inhibitors.

    Science.gov (United States)

    Copar, Anton; Prevec, Tadeja; Anzic, Borut; Mesar, Tomaz; Selic, Lovro; Vilar, Mateja; Solmajer, Tom

    2002-03-25

    Known carbapenem compounds with inhibitory effect towards beta-lactamase enzymes are formed from bicyclical beta lactam structural scaffolds. On the basis of results from theoretical computational methods and molecular modelling we have designed and developed a synthetic route towards novel, biologically active tricyclic derivatives of carbapenems.

  13. Design, construction and evaluation of a meteorological mobile mast ...

    African Journals Online (AJOL)

    A 30 metre meteorological mobile mast has been designed and constructed for upper air profile measurements. The parameters to be measured are wind speed, wind direction, temperature and relative humidity. The sensors for each parameter to be measured are constructed with locally available materials.

  14. Design, Fabrication and Evaluation of a Plantain Roaster | Ezekiel ...

    African Journals Online (AJOL)

    In this work, an electric roaster capable of roasting twenty-one plantain fingers per batch was designed, fabricated and tested. The roaster had two electric heating elements (one at the top and the other at the base of the roaster) supplying power at the rate of 2.4 kW. In addition ... However, sample at the upper layer

  15. Question Sets and Profiles: A Technique for Evaluating Building Design.

    Science.gov (United States)

    Scoffham, Stephen

    1982-01-01

    A questionnaire (survey sheet) has been developed focusing on some of the factors an architect has to consider in designing a house (site, appearance, suitability, and building maintenance). The use of the questionnaire by students and "spin off" activities are discussed. (Author/JN)

  16. Design and Evaluation of Accelerometer based Motional Feedback

    DEFF Research Database (Denmark)

    Schneider, Henrik; Pranjic, Emilio; Agerkvist, Finn T.

    2015-01-01

    and enable radical design changes in the loudspeaker which can lead to efficiency improvements. In combination this has motivated a revisit of the accelerometer based motional feedback technique. Experimental results on a 8 inch subwoofer show that the total harmonic distortion can be significantly reduced...

  17. Design requirements for SRB production control system. Volume 3: Package evaluation, modification and hardware

    Science.gov (United States)

    1981-01-01

    The software package evaluation was designed to analyze commercially available, field-proven, production control or manufacturing resource planning management technology and software package. The analysis was conducted by comparing SRB production control software requirements and conceptual system design to software package capabilities. The methodology of evaluation and the findings at each stage of evaluation are described. Topics covered include: vendor listing; request for information (RFI) document; RFI response rate and quality; RFI evaluation process; and capabilities versus requirements.

  18. Design, construction and evaluation of solarized airlift tubular photobioreactor

    International Nuclear Information System (INIS)

    Bahadur, A; Zubair, M; Khan, M B

    2013-01-01

    An innovative photobioreactor is developed for growing algae in simulated conditions. The proposed design comprises of a continuous tubular irradiance loop and air induced liquid circulation with gas separation through air lift device. The unique features of air lift system are to ensure the shear free circulation of sensitive algal culture and induce light/dark cycles to the photosynthetic micro-organisms. The design strategy employs to model and construct a 20-liter laboratory scale unit using Boro-silicate glass tubing. The material is selected to ensure maximum photon transmission. All components of the device are designed to have flexibility to be replaced with an alternative design, providing fair chance of modification for future investigators. The principles of fluid mechanics are applied to describe geometrical attributes of the air lift system. Combination of LEDs and Florescent tube lights (Warm white) were used to illuminate the photosynthesis reaction area providing a possibility to control both illumination duration and light intensity. 200 Watt Solar PV system is designed to power up the device which included air pump (100 Watt) and illumination system (100 Watt). Algal strain Chlorella sp was inoculated in photobioreactor which was sparged with air and carbon dioxide. The growth was sustained in the batch mode with daily monitoring of temperature, pH and biomass concentration. The novel photobioreactor recorded a maximum experimental average yield of 0.65 g/l.day (11.3 g/m 2 .day) as compared to theoretical modeled yield of 0.82 g/l.day (14.26 g/m 2 .day), suggesting the device can be efficiently and cost-effectively employed in the production of algal biomass for biofuels, concomitantly mitigating CO 2 .

  19. Evaluation and Design of Supply Chain Operations using DEA

    NARCIS (Netherlands)

    C.M. Chen (Chien-Ming)

    2009-01-01

    textabstractPerformance evaluation has been one of the most critical components in management. As production systems nowadays consist of a growing number of integrated and interacting processes, the interrelationship and dynamic among processes have create a major challenge in measuring system and

  20. Design and evaluation of a virtual gearshift application

    NARCIS (Netherlands)

    Tideman, Martijn; van der Voort, Mascha C.; van Houten, Frederikus J.A.M.

    2004-01-01

    When a customer buys a new car, he or she wants it to address personal preferences with respect to its driving behavior. By utilizing virtual reality technology, a virtual prototyping environment (VPE) can be created in which the behavior of a vehicle or part of a vehicle can be evaluated and

  1. Design and evaluation of a multithreaded many-core architecture

    NARCIS (Netherlands)

    Lankamp, M.

    2015-01-01

    Performance improvements for microprocessors have traditionally been achieved by increasing their clock frequency. However, this technique has reached a point where further scaling is impractical. This thesis describes and evaluates a novel System-on-Chip architecture that focuses on exploiting all

  2. A Preliminary Rubric Design to Evaluate Mixed Methods Research

    Science.gov (United States)

    Burrows, Timothy J.

    2013-01-01

    With the increase in frequency of the use of mixed methods, both in research publications and in externally funded grants there are increasing calls for a set of standards to assess the quality of mixed methods research. The purpose of this mixed methods study was to conduct a multi-phase analysis to create a preliminary rubric to evaluate mixed…

  3. Design and Evaluation of an Online Freshmen Course

    Directory of Open Access Journals (Sweden)

    Lewis McAnally Salas

    2000-05-01

    Full Text Available This paper describes the development of a prototype for an undergraduate online course tested with freshmen students taking mathematics for a B.Sc. in Oceanography.  The design of the prototype focuses on the six basic components for the selection and use of technologies in online teaching and learning; namely, a delivery and access, b control, c interaction, d symbolic characteristics of the medium e social presence and f human-machine interface. The results report the degree of satisfaction with the prototype and the course.  These results, obtained through questionnaires and semi-structured interviews, address issues concerning the structure and design of the online course.  The participants’ answers highlighted the easiness of navigation within the course and the effective communication obtained with the use of the course's electronic tools.

  4. Evaluating progressive-rendering algorithms in appearance design tasks.

    Science.gov (United States)

    Jiawei Ou; Karlik, Ondrej; Křivánek, Jaroslav; Pellacini, Fabio

    2013-01-01

    Progressive rendering is becoming a popular alternative to precomputational approaches to appearance design. However, progressive algorithms create images exhibiting visual artifacts at early stages. A user study investigated these artifacts' effects on user performance in appearance design tasks. Novice and expert subjects performed lighting and material editing tasks with four algorithms: random path tracing, quasirandom path tracing, progressive photon mapping, and virtual-point-light rendering. Both the novices and experts strongly preferred path tracing to progressive photon mapping and virtual-point-light rendering. None of the participants preferred random path tracing to quasirandom path tracing or vice versa; the same situation held between progressive photon mapping and virtual-point-light rendering. The user workflow didn’t differ significantly with the four algorithms. The Web Extras include a video showing how four progressive-rendering algorithms converged (at http://youtu.be/ck-Gevl1e9s), the source code used, and other supplementary materials.

  5. Structured tradeoffs preference elicitation: Evaluating CRWMS design and operations

    International Nuclear Information System (INIS)

    Hartman, H.

    1994-01-01

    Preliminary studies over the past few years have yielded multiple design and operations alternatives for the planned Civilian Radioactive Waste Management System (CRWMS). Waste isolation, pre-closure health and safety, and life cycle cost are among the many factors considered in developing these alternatives. The task of CRWMS designers is complicated by substantial heat and nuclear radiation energy output of the spent nuclear fuel and high level waste intended for disposal in an underground repository. Not only must the usual effectiveness, operability and cost objectives be balanced, but done so in the context of a constantly changing environment. Particular alternatives sometimes are favored by virtue of their outstanding performance relative to one of these factors. The Ultimate success of the potential repository, however, depends on reaching a defensible and traceable final decision through simultaneous and systematic weighing of all relevant factors. This paper documents the outcome of Structured Tradeoffs Preference (STP) elicitation as a method for the simultaneous and systematic weighing of factors relevant to repository thermal loading, waste package (WP) design, and emplacement mode decisions. The study provided a low-cost early indication of directions of further research on CRWMS design and operations likely to be most fruitful. The method of STP elicitation was utilized to avoid potential biases documented in other efforts which use only unstructured decision making, or open-quotes well-considered judgmentclose quotes. The STP elicitation procedure presented here complements the use of a parameter network-model pyramid suggested elsewhere in this proceedings to provide a framework for precisely articulating technical questions needing answers. It also forms an independent crosscheck of systems engineering study results and performance assessment modeling

  6. Comfort in using hand tools : theory, design and evaluation

    OpenAIRE

    Kuijt-Evers, L.F.M.

    2007-01-01

    Everyone uses hand tools in their daily life, like knife and fork. Moreover, many people use hand tools in their profession as well as during leisure time. It is important that they can work with hand tools that provide comfort. Until now, the avoidance of discomfort was emphasized during the design process of hand tools, like screwdrivers, hand saws and paint brushes. In the near future, the focus will shift towards providing comfort. However, some questions need to be answered to make this ...

  7. Design and Evaluation of a Reconfigurable Manufacturing System

    DEFF Research Database (Denmark)

    Zhang, Shuai; Li, Yang; Bilberg, Arne

    2014-01-01

    In modern manufacturing industry, reconfigurable manufacturing system (RMS) is a promising concept in the research arena. A new RMS system structure has been recently designed by a large consumer goods manufacturer in Europe, aiming to improve its production efficiency. This article shows...... implemented in this consumer goods manufacturer can be effectively (re)configured as part of the daily operations, and the configuration is analyzed by computer simulation before release. Flexibility can be increased considerably meanwhile the system can maintain an acceptable productivity....

  8. Design, formulation and evaluation of nicotine chewing gum

    OpenAIRE

    Abolfazl Aslani; Sahar Rafiei

    2012-01-01

    Background: Nicotine replacement therapy (NRT) can help smokers to quit smoking. Nicotine chewing gum has attracted the attention from pharmaceutical industries to offer it to consumers as an easily accessible NRT product. However, the bitter taste of such gums may compromise their acceptability by patients. This study was, therefore, designed to develop 2 and 4 mg nicotine chewing gums of pleasant taste, which satisfy the consumers the most. Materials and Methods: Nicotine, sugar, liquid...

  9. Evaluating the Design and Construction Flexibility of Traditional Malay House

    OpenAIRE

    Utaberta, Nangkula; Spalie, Nurhananie

    2011-01-01

    The ubiquitous terrace house is undeniably the most popular and affordable tihousing type in Malaysia. It has long been considered as one of the densest forms of property development and has become the common typology of accommodating the masses for this country. However, in Malaysia (like other third world countries), the design of a house has never grow from novelistic idea of style and revivalism. As stated by Tajuddin Rasdi (2003), housing in Malaysia has been plague with various issues f...

  10. Evaluation of aluminum drill-pipe material and design

    Energy Technology Data Exchange (ETDEWEB)

    Placido, Joao C. [PETROBRAS, Rio de Janeiro, RJ (Brazil); Lourenco, Marcelo I.; Netto, Theodoro Antoun [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Coordenacao dos Programas de Pos-graduacao de Engenharia (COPPE)

    2008-07-01

    Experimental program and numerical analyses were carried out to investigate the fatigue mechanisms of aluminum drill pipes designed and manufactured in compliance with ISO 15546. The main objective is to improve the fatigue performance of these components by selecting the appropriate aluminum alloy and by enhancing the mechanical design of the threaded steel connector. This paper presents the experimental test program and numerical analyses conducted on a drill-pipe of different materials (Al-Cu-Mg and Al-Zn-Mg system aluminum alloys) and geometry. Material mechanical properties, including S-N curve, were determined through small-scale tests on specimens cut from actual drill pipes. Full-scale experiments were also performed in laboratory. A finite element model of the drill pipe, including the tool-joint region, was developed. The model simulates, through different load steps, the tool-joint hot assembly, and then reproduces the physical experiments numerically in order to obtain the actual stress distribution. Good correlation between full-scale and small-scale fatigue tests was obtained by adjusting the strain/stress levels monitored in the full-scale tests in light of the numerical simulations and performing fatigue life calculations via multiaxial fatigue models. The weak points of the current practice design are highlighted for further development. (author)

  11. Biodiesel production from vegetable oil: Process design, evaluation and optimization

    Directory of Open Access Journals (Sweden)

    Kianimanesh Hamid Reza

    2017-09-01

    Full Text Available To investigate the effect of reactor performance/configuration of biodiesel production on process parameters (mass & energy consumption, required facilities etc., two diverse production processes (from vegetable oil were implemented/designed using Aspen HYSYS V7.2. Two series reactors were taken into account where overall conversion was set to be 97.7% and 70% in first and second processes respectively. Comparative analysis showed that an increase in conversion yield caused to consumption reduction of oil, methanol, cold energy and hot energy up to 9.1%, 22%, 67.16% and 60.28% respectively; further, a number of facilities (e.g. boiler, heat exchanger, distillation tower were reduced. To reduce mass & energy consumption, mass/heat integration method was employed. Applying integration method showed that in the first design, methanol, cold and hot energy were decreased by 49.81%, 17.46% and 36.17% respectively; while in the second design, oil, methanol, cold and hot energy were decreased by 9%, 60.57% 19.62% and 36.58% respectively.

  12. Integrated Technology Air Cleaners (ITAC): Design and Evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Fisk, William J.; Cohn, Sebastian; Destaillats, Hugo; Henzel, Victor; Sidheswaran, Meera; Sullivan, Douglas P.

    2013-09-13

    The primary objective of this project was to design, build, and test an air cleaner for residential use with the potential to substantially improve indoor air quality, or maintain indoor air quality unchanged, when outdoor air ventilation rates are reduced to save energy. Two air cleaners were designed and fabricated. The design targets for airflow rate, fan power, and projected cost were met. In short term laboratory studies, both units performed as expected; however, during field studies in homes, the formaldehyde removal performance of the air cleaners was much lower than expected. In subsequent laboratory studies, incomplete decomposition of some indoor air volatile organic compounds, with formaldehyde as a product of partial decomposition of volatile organic compounds, was confirmed as the explanation for the poor formaldehyde removal performance in the field studies. The amount of formaldehyde produced per unit of decomposition of other volatile organic compounds was substantially diminished by increasing the amount of catalyst on the filter and also by decreasing the air velocity. Together, these two measures reduced formaldehyde production, per unit destruction of other volatile organic compounds, by a factor of four, while increasing the removal efficiency of volatile organic compounds by a factor of 1.4. A company with a southern California office is conducting studies in conjunction with Lawrence Berkeley National Laboratory, with the goal of incorporating the ITAC catalytic air cleaning technology in their future commercial products.

  13. Walkability Explorer. An Evaluation and Design Support Tool for Walkability

    Directory of Open Access Journals (Sweden)

    Ivan Blečić

    2014-05-01

    Full Text Available Walkability Explorer is a software tool for the evaluation of urban walkability which, we argue, is an important aspect of the quality of life in cities. Many conventional approaches to the assessment of quality of life measure the distribution, density and distances of different opportunities in space. But distance is not all there is. To reason in terms of urban capabilities of people we should also take into account the quality of pedestrian accessibility and of urban opportunities offered by the city. The software tool we present in this paper is an user-friendly implementation of such an evaluation approach to walkability. It includes several GIS and analysis features, and is interoperable with other standard GIS and data-analysis tools.

  14. Experimental evaluation of human-system interaction on alarm design

    International Nuclear Information System (INIS)

    Huang, F.-H.; Lee, Y.-L.; Hwang, S.-L.; Yenn, T.-C.; Yu, Y.-C.; Hsu, C.-C.; Huang, H.-W.

    2007-01-01

    This study evaluates the practicability of automatic reset alarm system in Fourth Nuclear Power Plant (FNPP) of Taiwan. The features of auto-reset alarm system include dynamic prioritization of all alarm signals and fast system reset. Two experiments were conducted to evaluate the effect of automatic/manual reset on operation time, situational awareness (SA), task load index (TLX), and subjective ratings. All participants, including Experts and Novices, took part in the experiment on the alarm system simulator with Load Rejection procedure. The experimental results imply that the auto-reset alarm system may be applied in an advanced control room under Load Rejection procedure, because all participants' operation time were reduced as well as Novice's SA were raised up. Nevertheless, to ensure operating safety in FNPP, the effects of the auto-reset alarm system in other procedures/special situations still need to be tested in the near future

  15. Design and Qualitative Evaluation of Tactile Devices for Stroke Rehabilitation

    OpenAIRE

    Merrett, Geoff V; Metcalf, Cheryl D; Zheng, Deyi; Cunningham, Sarah; Barrow, Stuart; Demain, Sara H

    2011-01-01

    Rehabilitation environments combining virtual reality with everyday motor tasks can promote recovery from neurological illness, such as stroke. Tactile devices, providing physical stimulation to the skin, may improve motor retraining. While many tactile devices have been reported, there is a distinct paucity of studies evaluating how they are perceived. This multidisciplinary research has investigated three tactile devices (vibration motors, a motor-driven ‘squeezer’, and shape memory alloys)...

  16. Balanced Evaluation of Structural and Environmental Performances in Building Design

    Directory of Open Access Journals (Sweden)

    Marco Lamperti Tornaghi

    2018-03-01

    Full Text Available The design of new buildings, and even more the rehabilitation of existing ones, needs to satisfy modern criteria in terms of energy efficiency and environmental performance, within the context of adequate safety requirements. Tackling all these needs at the same time is cumbersome, as demonstrated by several experiences during recent earthquakes, where the improvement of energy performance vanished by seismic-induced damages. The costs of energy retrofitting must be added to the normal losses caused by the earthquake. Even though the minimum safety requirements are met (no collapse, the damage due to earthquake might be enough to waste the investment made to improve energy efficiency. Since these measures are often facilitated by corresponding incentives, the use of public funding is not cost effective. The application of the existing impact assessment methods is typically performed at the end of the architectural and structural design process. Thus, no real optimisation can be achieved, because a good structural solution could correspond to a poor environmental performance and vice versa. The proposed Sustainable Structural Design method (SSD considers both environmental and structural parameters in the life cycle perspective. The integration of environmental data in the structural performance is the focus of the method. Structural performances are considered in a probabilistic approach, through the introduction of a simplified Performance Based Assessment method. Finally, the SSD method is implemented with a case-study of an office-occupancy building, both for precast and cast-in-situ structural systems, with the aim to find the best solution in terms of sustainability and structural performance for the case at hand.

  17. Design grammars as evaluation tools in the first year studio

    DEFF Research Database (Denmark)

    Ibrahim, Mohamed S.; Bridges, Alan; Chase, Scott Curland

    2012-01-01

    This paper describes a teaching experience conducted and carried out as part of the coursework of first year students. The workshop is the third of three workshops planned to take place during the course of the first year studio, aimed at introducing new ways of thinking and introducing students...... to a new pattern of architectural education. The experiment was planned under the theme of “Evaluation” during the final stage. A grammatical approach was chosen to deliver the methodology in the design studio, based on shape grammars....

  18. The evaluation model of the design of toll

    Science.gov (United States)

    Feng, Shuting

    2018-04-01

    In recent years, the dramatic increase in traffic burden has highlighted the necessity of rational allocation of toll plaza. At the same time, the need to consider a lot of factors has enhanced the design requirements. In this background, we carry out research on this subject. We propose a reasonable assumption, and abstract the toll plaza into a model only related to B and L. By using the queuing theory and traffic flow theory, we define the throughput, cost and accident prevent with B and L to acquire the base model. By using the method of linear weighting in economics to calculate this model, the optimal B and L strategies are obtained.

  19. Design of Si-photonic structures to evaluate their radiation hardness dependence on design parameters

    International Nuclear Information System (INIS)

    Zeiler, M.; Detraz, S.; Olantera, L.; Pezzullo, G.; El Nasr-Storey, S. Seif; Sigaud, C.; Soos, C.; Troska, J.; Vasey, F.

    2016-01-01

    Particle detectors for future experiments at the HL-LHC will require new optical data transmitters that can provide high data rates and be resistant against high levels of radiation. Furthermore, new design paths for future optical readout systems for HL-LHC could be opened if there was a possibility to integrate the optical components with their driving electronics and possibly also the silicon particle sensors themselves. All these functionalities could potentially be combined in the silicon photonics technology which currently receives a lot of attention for conventional optical link systems. Silicon photonic test chips were designed in order to assess the suitability of this technology for deployment in high-energy physics experiments. The chips contain custom-designed Mach-Zehnder modulators, pre-designed ''building-block'' modulators, photodiodes and various other passive test structures. The simulation and design flow of the custom designed Mach-Zehnder modulators and some first measurement results of the chips are presented

  20. Human Information Behaviour and Design, Development and Evaluation of Information Retrieval Systems

    Science.gov (United States)

    Keshavarz, Hamid

    2008-01-01

    Purpose: The purpose of this paper is to introduce the concept of human information behaviour and to explore the relationship between information behaviour of users and the existing approaches dominating design and evaluation of information retrieval (IR) systems and also to describe briefly new design and evaluation methods in which extensive…

  1. New evaluation methods for conceptual design selection using computational intelligence techniques

    Energy Technology Data Exchange (ETDEWEB)

    Huang, Hong Zhong; Liu, Yu; Li, Yanfeng; Wang, Zhonglai [University of Electronic Science and Technology of China, Chengdu (China); Xue, Lihua [Higher Education Press, Beijing (China)

    2013-03-15

    The conceptual design selection, which aims at choosing the best or most desirable design scheme among several candidates for the subsequent detailed design stage, oftentimes requires a set of tools to conduct design evaluation. Using computational intelligence techniques, such as fuzzy logic, neural network, genetic algorithm, and physical programming, several design evaluation methods are put forth in this paper to realize the conceptual design selection under different scenarios. Depending on whether an evaluation criterion can be quantified or not, the linear physical programming (LPP) model and the RAOGA-based fuzzy neural network (FNN) model can be utilized to evaluate design alternatives in conceptual design stage. Furthermore, on the basis of Vanegas and Labib's work, a multi-level conceptual design evaluation model based on the new fuzzy weighted average (NFWA) and the fuzzy compromise decision-making method is developed to solve the design evaluation problem consisting of many hierarchical criteria. The effectiveness of the proposed methods is demonstrated via several illustrative examples.

  2. New evaluation methods for conceptual design selection using computational intelligence techniques

    International Nuclear Information System (INIS)

    Huang, Hong Zhong; Liu, Yu; Li, Yanfeng; Wang, Zhonglai; Xue, Lihua

    2013-01-01

    The conceptual design selection, which aims at choosing the best or most desirable design scheme among several candidates for the subsequent detailed design stage, oftentimes requires a set of tools to conduct design evaluation. Using computational intelligence techniques, such as fuzzy logic, neural network, genetic algorithm, and physical programming, several design evaluation methods are put forth in this paper to realize the conceptual design selection under different scenarios. Depending on whether an evaluation criterion can be quantified or not, the linear physical programming (LPP) model and the RAOGA-based fuzzy neural network (FNN) model can be utilized to evaluate design alternatives in conceptual design stage. Furthermore, on the basis of Vanegas and Labib's work, a multi-level conceptual design evaluation model based on the new fuzzy weighted average (NFWA) and the fuzzy compromise decision-making method is developed to solve the design evaluation problem consisting of many hierarchical criteria. The effectiveness of the proposed methods is demonstrated via several illustrative examples.

  3. Evaluating nanoparticle sensor design for intracellular pH measurements.

    Science.gov (United States)

    Benjaminsen, Rikke V; Sun, Honghao; Henriksen, Jonas R; Christensen, Nynne M; Almdal, Kristoffer; Andresen, Thomas L

    2011-07-26

    Particle-based nanosensors have over the past decade been designed for optical fluorescent-based ratiometric measurements of pH in living cells. However, quantitative and time-resolved intracellular measurements of pH in endosomes and lysosomes using particle nanosensors are challenging, and there is a need to improve measurement methodology. In the present paper, we have successfully carried out time-resolved pH measurements in endosomes and lyosomes in living cells using nanoparticle sensors and show the importance of sensor choice for successful quantification. We have studied two nanoparticle-based sensor systems that are internalized by endocytosis and elucidated important factors in nanosensor design that should be considered in future development of new sensors. From our experiments it is clear that it is highly important to use sensors that have a broad measurement range, as erroneous quantification of pH is an unfortunate result when measuring pH too close to the limit of the sensitive range of the sensors. Triple-labeled nanosensors with a pH measurement range of 3.2-7.0, which was synthesized by adding two pH-sensitive fluorophores with different pK(a) to each sensor, seem to be a solution to some of the earlier problems found when measuring pH in the endosome-lysosome pathway.

  4. Detector design and evaluation for the solenoidal tracker at RHIC

    International Nuclear Information System (INIS)

    Howe, H.; Ahmad, S.; Bonner, B.E.

    1992-01-01

    There are two components to this research, both at the high-η ends of the STAR detector to be built in Brookhaven in 1997. The first project is to design the start counters to be placed along the incident beam-pipe. These detectors will be used to determine the starting time for the TOF layer, which, in conjunction with the main low-η TPC detectors, will determine particle identification. The TOF system will need a time resolution of 100 ps, which must be reflected in the start counter design. The start counter will detect particles emitted with pseudorapidities of η-4.5-5.5, and the size of the counter is dependent on the placement of the counter along the beam pipe. The authors will also explore start counter segmentation and light collection from the scintillator. Second, they are using computer simulation to try to calculate the initial momentum of particles, given their crossing points through the high-η TPCs. A computer model can give one such track through the TPCs. By modelling the track of the particle back through an ideal magnetic field, the authors can estimate the initial momentum. Then, based on this momentum, they project the particle through a complex magnetic field corresponding to the actual field generated and determine where that particle strikes the TPCs. By then varying the initial momentum slightly, they can minimize the difference between such tracks and the original track and, thus, accurately calculate the initial momentum

  5. Methodological Considerations in Designing and Evaluating Animal-Assisted Interventions.

    Science.gov (United States)

    Stern, Cindy; Chur-Hansen, Anna

    2013-02-27

    This paper presents a discussion of the literature on animal-assisted interventions and describes limitations surrounding current methodological quality. Benefits to human physical, psychological and social health cannot be empirically confirmed due to the methodological limitations of the existing body of research, and comparisons cannot validly be made across different studies. Without a solid research base animal-assisted interventions will not receive recognition and acceptance as a credible alternative health care treatment. The paper draws on the work of four systematic reviews conducted over April-May 2009, with no date restrictions, focusing exclusively on the use of canine-assisted interventions for older people residing in long-term care. The reviews revealed a lack of good quality studies. Although the literature base has grown in volume since its inception, it predominantly consists of anecdotal accounts and reports. Experimental studies undertaken are often flawed in aspects of design, conduct and reporting. There are few qualitative studies available leading to the inability to draw definitive conclusions. It is clear that due to the complexities associated with these interventions not all weaknesses can be eliminated. However, there are basic methodological weaknesses that can be addressed in future studies in the area. Checklists for quantitative and qualitative research designs to guide future research are offered to help address methodological rigour.

  6. Introduction of Autonomous Vehicles: Roundabouts Design and Safety Performance Evaluation

    Directory of Open Access Journals (Sweden)

    Aleksandra Deluka Tibljaš

    2018-04-01

    Full Text Available Driving experiences provided by the introduction of new vehicle technologies are directly impacting the criteria for road network design. New criteria should be taken into consideration by designers, researchers and car owners in order to assure traffic safety in changed conditions that will appear with, for example, introduction of Autonomous Vehicles (AVs in everyday traffic. In this paper, roundabout safety level is analysed on the originally developed microsimulation model in circumstances where different numbers of AVs vehicles are mixed with Conventional Vehicles (CVs. Field data about speed and traffic volumes from existing roundabouts in Croatia were used for development of the model. The simulations done with the Surrogate Safety Assessment Model (SSAM give some relevant highlights on how the introduction of AVs could change both operational and safety parameters at roundabouts. To further explore the effects on safety of roundabouts with the introduction of different shares of AVs, hypothetical safety treatments could be tested to explore whether their effects may change, leading to the estimation of a new set of Crash Modification Factors.

  7. Assessing the 'system' in safe systems-based road designs: using cognitive work analysis to evaluate intersection designs.

    Science.gov (United States)

    Cornelissen, M; Salmon, P M; Stanton, N A; McClure, R

    2015-01-01

    While a safe systems approach has long been acknowledged as the underlying philosophy of contemporary road safety strategies, systemic applications are sparse. This article argues that systems-based methods from the discipline of Ergonomics have a key role to play in road transport design and evaluation. To demonstrate, the Cognitive Work Analysis framework was used to evaluate two road designs - a traditional Melbourne intersection and a cut-through design for future intersections based on road safety safe systems principles. The results demonstrate that, although the cut-through intersection appears different in layout from the traditional intersection, system constraints are not markedly different. Furthermore, the analyses demonstrated that redistribution of constraints in the cut-through intersection resulted in emergent behaviour, which was not anticipated and could prove problematic. Further, based on the lack of understanding of emergent behaviour, similar design induced problems are apparent across both intersections. Specifically, incompatibilities between infrastructure, vehicles and different road users were not dealt with by the proposed design changes. The importance of applying systems methods in the design and evaluation of road transport systems is discussed. Copyright © 2013 Elsevier Ltd. All rights reserved.

  8. Development of design window evaluation and display system. 1. System development and performance confirmation

    International Nuclear Information System (INIS)

    Muramatsu, Toshiharu; Yamaguchi, Akira

    2003-07-01

    Purpose: The work was performed to develop a design window evaluation and display system for the purpose of obtaining the effects of various design parameters on the typical thermal hydraulic issues resulting from a use of various kind of working fluid etc. easily. Method: The function of the system were 'confirmation of design margin' of the present design, 'confirmation of the affected design zone' when a designer changed some design parameter, and search for an design improvement' for design optimization. The system was developed using existing soft wares on PC and the database relating analytical results of typical thermal hydraulic issues provided by separate work. Results: (1) System design: In order to develop a design window evaluation and display system, 'numerical analysis unit', 'statistical analysis unit', 'MMI unit', 'optimization unit' were designed based on the result of selected optimization procedure and display visualization. Further, total system design was performed combining these units. Typical thermal hydraulic issues to be considered are upper plenum thermal hydraulics, thermal stratification, free surface sloshing, flow-induced vibration of a heat exchanger and thermal striping in the T-junction piping systems. (2) Development of prototype system and a functional check: A prototype system of a design window evaluation and display system was developed and the functions were confirmed as was planned. (author)

  9. Evaluation of Embedded System Component Utilized in Delivery Integrated Design Project Course

    Science.gov (United States)

    Junid, Syed Abdul Mutalib Al; Hussaini, Yusnira; Nazmie Osman, Fairul; Razak, Abdul Hadi Abdul; Idros, Mohd Faizul Md; Karimi Halim, Abdul

    2018-03-01

    This paper reports the evaluation of the embedded system component utilized in delivering the integrated electronic engineering design project course. The evaluation is conducted based on the report project submitted as to fulfil the assessment criteria for the integrated electronic engineering design project course named; engineering system design. Six projects were assessed in this evaluation. The evaluation covers the type of controller, programming language and the number of embedded component utilization as well. From the evaluation, the C-programming based language is the best solution preferred by the students which provide them flexibility in the programming. Moreover, the Analog to Digital converter is intensively used in the projects which include sensors in their proposed design. As a conclusion, in delivering the integrated design project course, the knowledge over the embedded system solution is very important since the high density of the knowledge acquired in accomplishing the project assigned.

  10. An Application of the Impact Evaluation Process for Designing a Performance Measurement and Evaluation Framework in K-12 Environments

    Science.gov (United States)

    Guerra-Lopez, Ingrid; Toker, Sacip

    2012-01-01

    This article illustrates the application of the Impact Evaluation Process for the design of a performance measurement and evaluation framework for an urban high school. One of the key aims of this framework is to enhance decision-making by providing timely feedback about the effectiveness of various performance improvement interventions. The…

  11. Design, Synthesis and Evaluation of Antiproliferative Activity of New Benzimidazolehydrazones

    Directory of Open Access Journals (Sweden)

    Valentina Onnis

    2016-04-01

    Full Text Available The synthesis and antiproliferative activity of new benzimidazole derivatives bearing an hydrazone mojety at the 2-position is described. The new N′-(4-arylidene-1H-benzo[d]imidazole-2-carbohydrazides were evaluated for their cytostatic activity toward the murine leukemia (L1210, human T-cell leukemia (CEM, human cervix carcinoma (HeLa and human pancreas carcinoma cells (Mia Paca-2. A preliminary structure-activity relationship could be defined. Some of the compounds possess encouraging and consistent antiproliferative activity, having IC50 values in the low micromolar range.

  12. Versatile by design

    CERN Multimedia

    Katarina Anthony

    2014-01-01

    CHARM (CERN High energy AcceleRator Mixed field) is a new and unique testing facility that will complete CERN's radiation testing installations. Located in the East Area, CHARM will provide teams with a venue to test their equipment in radiation environments similar to those found in the accelerator chain.   Team at work in the irradiation zone of the CHARM facility. First envisaged in 2007, the CHARM facility fulfils a growing demand for a large-scale tailor-made radiation testing facility. Unlike commercial facilities, CHARM features a wide spectrum of radiation types and energies (called mixed-field radiation environments), the space to test large equipment and even the possibility to adjust the environment using mobile shielding. "CHARM is versatile by design, allowing us to recreate any of the radiation environments found in the accelerator chain," says Markus Brugger, head of the R2E (Radiation to Electronics) project team that developed the CHARM facility. &a...

  13. An investigative study towards constructing anthropocentric Man-Machine System design evaluation methodology

    International Nuclear Information System (INIS)

    Yoshikawa, H.; Gofuku, A.; Itoh, T.; Sasaki, K.

    1992-01-01

    A methodological investigation has been conducted for evaluating the reliability of man-machine interaction in the total Man-Machine System (MMS) from the view-point of safety maintenance for emergent situations of nuclear power plant. Basic considerations in our study are: (i) what are the MMS design data to be evaluated, (ii) how are those MMS design data should be treated, and (iii) how the introduction effects of various operator support tools can be evaluated. The methods of both qualitative and quantitative MMS design evaluation are summarized in this paper, with the system architecture based on man-machine interaction simulation and the related cognitive human error factor analysis. (author)

  14. A tool for early workstation design for small and medium enterprises evaluated in five cases

    NARCIS (Netherlands)

    Hallbeck, M.S.; Bosch, T.; Rhijn, J.W.van; Krause, F.; Looze, M.P.de; Vink, P.

    2010-01-01

    Five case studies on production line design were described to study the effect of an early design support tool. Based on these case studies, the simple, interactive, real-time, medium-fidelity, mixed-reality methodology was not only found to be a good early design stage evaluative tool for

  15. Economic evaluation of interventions designed to reduce Clostridium difficile infection.

    Science.gov (United States)

    Brain, David; Yakob, Laith; Barnett, Adrian; Riley, Thomas; Clements, Archie; Halton, Kate; Graves, Nicholas

    2018-01-01

    Healthcare decision-makers are increasingly expected to balance increasing demand for health services with a finite budget. The role of economic evaluation in healthcare is increasing and this research provides decision-makers with new information about the management of Clostridium difficile infection, from an economic perspective. A model-based economic evaluation was undertaken to identify the most cost-effective healthcare intervention relating to the reduction of Clostridium difficile transmission. Efficacy evidence was synthesised from the literature and was used to inform the effectiveness of both bundled approaches and stand-alone interventions, where appropriate intervention combinations were coupled together. Changes in health outcomes were estimated by combining information about intervention effectiveness and its subsequent impact on quality of life. A bundled approach of improving hand hygiene and environmental cleaning produces the best combination of increased health benefits and cost-savings. It has the highest mean net monetary benefit when compared to all other interventions. This intervention remains the optimal decision under different clinical circumstances, such as when mortality rate and patient length of stay are increased. Bundled interventions offered the best opportunity for health improvements. These findings provide healthcare decision-makers with novel information about the allocation of scarce resources relating to Clostridium difficile. If investments are not made in interventions that clearly yield gains in health outcomes, the allocation and use of scarce healthcare resources is inappropriate and improvements in health outcomes will be forgone.

  16. Economic evaluation of interventions designed to reduce Clostridium difficile infection.

    Directory of Open Access Journals (Sweden)

    David Brain

    Full Text Available Healthcare decision-makers are increasingly expected to balance increasing demand for health services with a finite budget. The role of economic evaluation in healthcare is increasing and this research provides decision-makers with new information about the management of Clostridium difficile infection, from an economic perspective.A model-based economic evaluation was undertaken to identify the most cost-effective healthcare intervention relating to the reduction of Clostridium difficile transmission. Efficacy evidence was synthesised from the literature and was used to inform the effectiveness of both bundled approaches and stand-alone interventions, where appropriate intervention combinations were coupled together. Changes in health outcomes were estimated by combining information about intervention effectiveness and its subsequent impact on quality of life.A bundled approach of improving hand hygiene and environmental cleaning produces the best combination of increased health benefits and cost-savings. It has the highest mean net monetary benefit when compared to all other interventions. This intervention remains the optimal decision under different clinical circumstances, such as when mortality rate and patient length of stay are increased. Bundled interventions offered the best opportunity for health improvements.These findings provide healthcare decision-makers with novel information about the allocation of scarce resources relating to Clostridium difficile. If investments are not made in interventions that clearly yield gains in health outcomes, the allocation and use of scarce healthcare resources is inappropriate and improvements in health outcomes will be forgone.

  17. Design and evaluate alginate nanoparticles as a protein delivery system

    Directory of Open Access Journals (Sweden)

    Saraei, F.

    2013-12-01

    Full Text Available In recent years, encapsulation of drugs and antigens in hydrogels, specifically in calcium alginate particles, is an interesting and practical technique that was developed widespread. It is well known that alginate solution, under proper conditions, can form suitable nanoparticles as a promising carrier system, for vaccine delivery. The aim of this study was to synthesis alginate nanoparticles as protein carrier and to evaluate the influence of various factors on nanoparticles properties. Alginate nanoparticles were prepared by ionic gelation method. Briefly, various concentrations of CaCl2 were added to different concentrations of sodium alginate dropwisly by homogenizing magnetically at 1300 rpm. The effects of homogenization time and (- rate were investigated on nanoparticle feature. Nanoparticles were characterized for their morphology and size distribution. Evaluation of loading capacity and loading efficiency of nanoparticles were performed by using various concentration of BSA. The concentration of 0.3%w/v sodium alginate and 0.1%w/v CaCl2 solution, homogenization time 45 min and homogenization rate 1300 rpm were observed as suitable condition - to prepare optimized nanoparticles. It can be concluded that the properties of nanoparticles are strongly dependent on the physicochemical conditions. The optimum concentrations of alginate and CaCl2and appropriate condition led to forming desirable nanoparticles that can be used as carrier for drug and vaccine delivery.

  18. Design and evaluation of the ONC health information technology curriculum.

    Science.gov (United States)

    Mohan, Vishnu; Abbott, Patricia; Acteson, Shelby; Berner, Eta S; Devlin, Corkey; Hammond, William E; Kukafka, Rita; Hersh, William

    2014-01-01

    As part of the Heath Information Technology for Economic and Clinical Health (HITECH) Act, the Office of the National Coordinator for Health Information Technology (ONC) implemented its Workforce Development Program, which included initiatives to train health information technology (HIT) professionals in 12 workforce roles, half of them in community colleges. To achieve this, the ONC tasked five universities with established informatics programs with creating curricular materials that could be used by community colleges. The five universities created 20 components that were made available for downloading from the National Training and Dissemination Center (NTDC) website. This paper describes an evaluation of the curricular materials by its intended audience of educators. We measured the quantity of downloads from the NTDC site and administered a survey about the curricular materials to its registered users to determine use patterns and user characteristics. The survey was evaluated using mixed methods. Registered users downloaded nearly half a million units or components from the NTDC website. We surveyed these 9835 registered users. 1269 individuals completed all or part of the survey, of whom 339 identified themselves as educators (26.7% of all respondents). This paper addresses the survey responses of educators. Successful aspects of the curriculum included its breadth, convenience, hands-on and course planning capabilities. Several areas were identified for potential improvement. The ONC HIT curriculum met its goals for community college programs and will likely continue to be a valuable resource for the larger informatics community in the future.

  19. Safety-Evaluation Report related to the D2/D3 steam-generator design modification

    International Nuclear Information System (INIS)

    1983-03-01

    This Safety Evaluation Report (SER) related to the D2/D3 steam generator design modification has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. The purpose of this SER is to issue the staff's evaluation of the acceptability of the design modification for both installation and full-power operation in the D2/D3 steam generators based on the Design Review Panel Report of January 1983

  20. Design and experimental evaluation of flexible manipulator control algorithms

    International Nuclear Information System (INIS)

    Kwon, D.S.; Hwang, D.H.; Babcock, S.M.; Kress, R.L.

    1995-01-01

    Within the Environmental Restoration and Waste Management Program of the US Department of Energy, the remediation of single-shell radioactive waste storage tanks is one of the areas that challenge state-of-the-art equipment and methods. The use of long-reach manipulators is being seriously considered for this task. Because of high payload capacity and high length-to-cross-section ratio requirements, these long-reach manipulator systems are expected to use hydraulic actuators and to exhibit significant structural flexibility. The controller has been designed to compensate for the hydraulic actuator dynamics by using a load-compensated velocity feedforward loop and to increase the bandwidth by using an inner pressure feedback loop. Shaping filter techniques have been applied as feedforward controllers to avoid structural vibrations during operation. Various types of shaping filter methods have been investigated. Among them, a new approach, referred to as a ''feedforward simulation filter'' that uses embedded simulation, has been presented

  1. Design and Evaluation of Novel Polymyxin Fluorescent Probes

    Directory of Open Access Journals (Sweden)

    Bo Yun

    2017-11-01

    Full Text Available Polymyxins (polymyxin B and colistin are cyclic lipopeptide antibiotics that serve as a last-line defence against Gram-negative “superbugs”. In the present study, two novel fluorescent polymyxin probes were designed through regio-selective modifications of the polymyxin B core structure at the N-terminus and the hydrophobic motif at positions 6 and 7. The resulting probes, FADDI-285 and FADDI-286 demonstrated comparable antibacterial activity (MICs 2–8 mg/L to polymyxin B and colistin (MICs 0.5–8 mg/L against a panel of gram-negative clinical isolates of Acinetobacter baumannii, Klebsiella pneumoniae and Pseudomonas aeruginosa. These probes should prove to be of considerable utility for imaging cellular uptake and mechanistic investigations of these important last-line antibiotics.

  2. Evaluating Nanoparticle Sensor Design for Intracellular pH Measurements

    DEFF Research Database (Denmark)

    Benjaminsen, Rikke Vicki; Sun, Honghao; Henriksen, Jonas Rosager

    2011-01-01

    Particle-based nanosensors have over the last decade been designed for optical fluorescent-based ratiometric measurements of pH in living cells. However, quantitative and time-resolved intracellular measurements of pH in endosomes and lysosomes using particle nanosensors is challenging...... and there is a need to improve measurement methodology. In the present paper, we have successfully carried out time resolved pH measurements in endosomes and lyosomes in living cells using nanoparticle sensors and show the importance of sensor choice for successful quantification. We have studied two nanoparticle...... quantification of pH is an unfortunate result when measuring pH too close to the limit of the sensitive range of the sensors. Triple-labeled nanosensors with a pH measurement range of 3.2-7.0, which was synthesized by adding two pH-sensitive fluorophores with different pKa to each sensor, seem to be a solution...

  3. Design, operation, and evaluation of the transportable vitrification system

    International Nuclear Information System (INIS)

    Zamecnik, J.R.; Young, S.R.; Hansen, E.K.; Whitehouse, J.C.

    1997-01-01

    The Transportable Vitrification System (TVS) is a transportable melter system designed to demonstrate the treatment of low-level and mixed hazardous and radioactive wastes such as wastewater treatment sludges, contaminated soils and incinerator ash. The TVS is a large-scale, fully integrated vitrification system consisting of melter feed preparation, melter, offgas, service, and control modules. The TVS was tested with surrogate waste at the Clemson University Environmental Systems Engineering Department's (ESED) DOE/Industry Center for Vitrification Research prior to being shipped to the DOE Oak Ridge Reservation (ORR) K-25 site for treatment of mixed waste. This testing, along with additional testing at ORR, proved that the TVS would be able to successfully treat mixed waste. These surrogate tests consistently produced glass that met the EPA Toxicity Characteristic Leaching Procedure (TCLP). Performance of the system resulted in acceptable emissions of regulated metals from the offgas system. The TVS is scheduled to begin mixed waste operations at ORR in June 1997

  4. Error evaluation of inelastic response spectrum method for earthquake design

    International Nuclear Information System (INIS)

    Paz, M.; Wong, J.

    1981-01-01

    Two-story, four-story and ten-story shear building-type frames subjected to earthquake excitaion, were analyzed at several levels of their yield resistance. These frames were subjected at their base to the motion recorded for north-south component of the 1940 El Centro earthquake, and to an artificial earthquake which would produce the response spectral charts recommended for design. The frames were first subjected to 25% or 50% of the intensity level of these earthquakes. The resulting maximum relative displacement for each story of the frames was assumed to be yield resistance for the subsequent analyses at 100% of intensity for the excitation. The frames analyzed were uniform along their height with the stiffness adjusted as to result in 0.20 seconds of the fundamental period for the two-story frame, 0.40 seconds for the four-story frame and 1.0 seconds for the ten-story frame. Results of the study provided the following conclusions: (1) The percentage error in floor displacement for linear behavior was less than 10%; (2) The percentage error in floor displacement for inelastic behavior (elastoplastic) could be as high as 100%; (3) In most of the cases analyzed, the error increased with damping in the system; (4) As a general rule, the error increased as the modal yield resistance decreased; (5) The error was lower for the structures subjected to the 1940 E1 Centro earthquake than for the same structures subjected to an artificial earthquake which was generated from the response spectra for design. (orig./HP)

  5. Designing and evaluating a persuasive child restraint television commercial.

    Science.gov (United States)

    Lewis, Ioni; Ho, Bonnie; Lennon, Alexia

    2016-01-01

    Relatively high rates of child restraint inappropriate use and misuse and faults in the installation of restraints have suggested a crucial need for public education messages to raise parental awareness of the need to use restraints correctly. This project involved the devising and pilot testing of message concepts, filming of a television advertisement (the TVC), and the evaluation of the TVC. This article focuses specifically upon the evaluation of the TVC. The development and evaluation of the TVC were guided by an extended theory of planned behavior that included the standard constructs of attitudes, subjective norms, and perceived behavioral control as well as the additional constructs of group norms and descriptive norms. The study also explored the extent to which parents with low and high intentions to self-check restraints differed on salient beliefs regarding the behavior. An online survey of parents (N = 384) was conducted where parents were randomly assigned to either the intervention group (n = 161), and therefore viewed the advertisement within the survey, or the control group (n = 223), and therefore did not view the advertisement. Following a one-off exposure to the TVC, the results indicated that, although not a significant difference, parents in the intervention group reported stronger intentions (M = 4.43, SD = 0.74) to self-check restraints than parents in the control group (M = 4.18, SD = 0.86). In addition, parents in the intervention group (M = 4.59, SD = 0.47) reported significantly higher levels of perceived behavioral control than parents in the control group (M = 4.40, SD = 0.73). The regression results revealed that, for parents in the intervention group, attitudes and group norms were significant predictors of parental intentions to self-check their child restraint. Finally, the exploratory analyses of parental beliefs suggested that those parents with low intentions to self-check child restraints were significantly more likely than

  6. Study, design and evaluation of nuclear reactor computer control system

    International Nuclear Information System (INIS)

    Menacer, S.

    1988-01-01

    Nuclear reactor control is a complex process that varies with each reactor and there is no universal agreement as to the best type of control system. After the use of conventional systems for a long time, attention turned towards digital techniques in the reactor control system. This interest emerged because of the difficulties faced in the data manipulation, mainly for post-incident analysis. However, it is not sufficient to insert a computer in a system to solve all the data-handling problems and also the insertion of a computer in a real-time system is not without any effect on the overall system. The scope of this thesis is to show the important parameters that have to be taken into account when choosing and evaluate the performances of the selected system

  7. A recoil resilient lumen support, design, fabrication and mechanical evaluation

    Science.gov (United States)

    Mehdizadeh, Arash; Ali, Mohamed Sultan Mohamed; Takahata, Kenichi; Al-Sarawi, Said; Abbott, Derek

    2013-06-01

    Stents are artificial implants that provide scaffolding to a cavity inside the body. This paper presents a new luminal device for reducing the mechanical failure of stents due to recoil, which is one of the most important issues in stenting. This device, which we call a recoil-resilient ring (RRR), is utilized standalone or potentially integrated with existing stents to address the problem of recoil. The proposed structure aims to minimize the need for high-pressure overexpansion that can induce intra-luminal trauma and excess growth of vascular tissue causing later restenosis. The RRR is an overlapped open ring with asymmetrical sawtooth structures that are intermeshed. These teeth can slide on top of each other, while the ring is radially expanded, but interlock step-by-step so as to keep the final expanded state against compressional forces that normally cause recoil. The RRRs thus deliver balloon expandability and, when integrated with a stent, bring both radial rigidity and longitudinal flexibility to the stent. The design of the RRR is investigated through finite element analysis (FEA), and then the devices are fabricated using micro-electro-discharge machining of 200-µm-thick Nitinol sheet. The standalone RRR is balloon expandable in vitro by 5-7 Atm in pressure, which is well within the recommended in vivo pressure ranges for stenting procedures. FEA compression tests indicate 13× less reduction of the cross-sectional area of the RRR compared with a typical stainless steel stent. These results also show perfect elastic recovery of the RRR after removal of the pressure compared to the remaining plastic deformations of the stainless steel stent. On the other hand, experimental loading tests show that the fabricated RRRs have 2.8× radial stiffness compared to a two-column section of a commercial stent while exhibiting comparable elastic recovery. Furthermore, testing of in vitro expansion in a mock artery tube shows around 2.9% recoil, approximately 5-11

  8. Evaluation on licensability of KNGR system design (II)

    Energy Technology Data Exchange (ETDEWEB)

    Park, G. C.; Seo, K. R. [Seoul National Univ., Seoul (Korea, Republic of); Kim, J. K. [Hanyang Univ., Seoul (Korea, Republic of)] (and others)

    2001-01-15

    The CE methodology of DBA analysis are reviewed. Though UPTF test is different from the KNGR in the geometrical configuration of the down-corner, this was used as a reference to investigate the validity of CEFLASH and COMPERC-II codes in DBA analysis of KNGR. it revealed that CEFLASH is conservative but COMPERC-II for the Refill and Reflood phase is needed for the detailed investigation on ECC bypass, Entrainment, condensation phenomena, CCFL. The direct bypass rate based on the benchmark problem was quantitatively measured. The test model was scaled by the linear scaling methodology, and the accident conditions were the reflood phase at a CB-DEGB LBLOCA. The initial total air flow rate was determined considering the volume scaling factor (1/1000) on criteria of the KNGR design value. The volume rates of ECC water injected: through the DVI nozzles were changed for several case. The direct bypass ratio was about 22 % on the condition of the KNGR scaled-down air volume flow and ECC water velocity at about 1 m/s. The fast neutron fluence at the Reactor Pressure Vessel(RPV) of KNGR designed for 60 years of lifetime was calculated by Monte Carlo simulations and Discrete Ordinates Method for reactor pressure vessel integrity assessment. KNGR core geometry was modeled on a three-dimensional. In the full-scope Monte Carlo method, the maximum fast neutron flux at inner vessel belt line was estimated as 2.738 x 10{sup 10} neutrons/cm{sup 2}{center_dot}see. In the ROCS+MCNP4B calculation, the maximum flux of 2.769 x 10{sup 10} neutrons/ cm{sup 2}{center_dot}see at the RPV was obtained by tallying neutrons crossing the inner surface of the RPV. In ROCS+TORT Calculation, the maximum flux of 3.190 x 10{sup 10} neutrons/cm{sup 2} {center_dot}see was obtained at inner RPV belt line. The lifetime of KNGR was estimated on the basis of conservative end of life fluence limit value of the ABB-CE System 80+. Approximately, 72 Effective Full Power Years (EFPYs), equivalent to 90 calendar

  9. A recoil resilient lumen support, design, fabrication and mechanical evaluation

    International Nuclear Information System (INIS)

    Mehdizadeh, Arash; Al-Sarawi, Said; Abbott, Derek; Ali, Mohamed Sultan Mohamed; Takahata, Kenichi

    2013-01-01

    Stents are artificial implants that provide scaffolding to a cavity inside the body. This paper presents a new luminal device for reducing the mechanical failure of stents due to recoil, which is one of the most important issues in stenting. This device, which we call a recoil-resilient ring (RRR), is utilized standalone or potentially integrated with existing stents to address the problem of recoil. The proposed structure aims to minimize the need for high-pressure overexpansion that can induce intra-luminal trauma and excess growth of vascular tissue causing later restenosis. The RRR is an overlapped open ring with asymmetrical sawtooth structures that are intermeshed. These teeth can slide on top of each other, while the ring is radially expanded, but interlock step-by-step so as to keep the final expanded state against compressional forces that normally cause recoil. The RRRs thus deliver balloon expandability and, when integrated with a stent, bring both radial rigidity and longitudinal flexibility to the stent. The design of the RRR is investigated through finite element analysis (FEA), and then the devices are fabricated using micro-electro-discharge machining of 200-µm-thick Nitinol sheet. The standalone RRR is balloon expandable in vitro by 5–7 Atm in pressure, which is well within the recommended in vivo pressure ranges for stenting procedures. FEA compression tests indicate 13× less reduction of the cross-sectional area of the RRR compared with a typical stainless steel stent. These results also show perfect elastic recovery of the RRR after removal of the pressure compared to the remaining plastic deformations of the stainless steel stent. On the other hand, experimental loading tests show that the fabricated RRRs have 2.8× radial stiffness compared to a two-column section of a commercial stent while exhibiting comparable elastic recovery. Furthermore, testing of in vitro expansion in a mock artery tube shows around 2.9% recoil, approximately 5

  10. Virtual Display Design and Evaluation of Clothing: A Design Process Support System

    Science.gov (United States)

    Zhang, Xue-Fang; Huang, Ren-Qun

    2014-01-01

    This paper proposes a new computer-aided educational system for clothing visual merchandising and display. It aims to provide an operating environment that supports the various stages of display design in a user-friendly and intuitive manner. First, this paper provides a brief introduction to current software applications in the field of…

  11. Augmented reality for art, design and cultural heritage-system design and evaluation

    NARCIS (Netherlands)

    Caarls, J.; Jonker, P.P.; Kolstee, Y.; Rotteveel, J.; Eck, van W.

    2010-01-01

    This paper describes the design of an optical see-through head-mounted display (HMD) system for Augmented Reality (AR). Our goals were to make virtual objects "perfectly" indistinguishable from real objects, wherever the user roams, and to find out to which extent imperfections are hindering

  12. Toward time-based design: Creating an applied time evaluation checklist for urban design research

    Directory of Open Access Journals (Sweden)

    Amir Shakibamanesh

    2017-09-01

    Full Text Available The perception of a 3D space, in which movement takes place, is subjectively based on experience. The pedestrians’ perception of subjective duration is one of the related issues that receive little attention in urban design literature. Pedestrians often misperceive the required time to pass a certain distance. A wide range of factors affects one׳s perception of time in urban environments. These factors include individual factors (e.g., gender, age, and psychological state, social and cultural contexts, purpose and motivation for being in the space, and knowledge of the given area. This study aims to create an applied checklist that can be used by urban designers in analyzing the effects of individual experience on subjective duration. This checklist will enable urban designers to perform a phenomenological assessment of time perception and compare this perception in different urban spaces, thereby improving pedestrians’ experiences of time through a purposeful design. A combination of exploratory and descriptive analytical research is used as methodology due to the complexity of time perception.

  13. Evaluating a digital ship design tool prototype: Designers' perceptions of novel ergonomics software.

    Science.gov (United States)

    Mallam, Steven C; Lundh, Monica; MacKinnon, Scott N

    2017-03-01

    Computer-aided solutions are essential for naval architects to manage and optimize technical complexities when developing a ship's design. Although there are an array of software solutions aimed to optimize the human element in design, practical ergonomics methodologies and technological solutions have struggled to gain widespread application in ship design processes. This paper explores how a new ergonomics technology is perceived by naval architecture students using a mixed-methods framework. Thirteen Naval Architecture and Ocean Engineering Masters students participated in the study. Overall, results found participants perceived the software and its embedded ergonomics tools to benefit their design work, increasing their empathy and ability to understand the work environment and work demands end-users face. However, participant's questioned if ergonomics could be practically and efficiently implemented under real-world project constraints. This revealed underlying social biases and a fundamental lack of understanding in engineering postgraduate students regarding applied ergonomics in naval architecture. Copyright © 2016 Elsevier Ltd. All rights reserved.

  14. Health-economic evaluation in implant trials: design considerations.

    Science.gov (United States)

    Alt, Volker; Pavlidis, Theodoros; Szalay, Gabor; Heiss, Christian; Schnettler, Reinhard

    2009-01-01

    In today's world, demonstration of the safety, efficacy, and quality of a new treatment strategy is no longer sufficient in many countries for market entry and reimbursement in the public healthcare system. This implies that new implants in orthopedic and orthopedic trauma surgery not only must be shown to lead to better medical outcome compared with the standard of care implant, but also must be shown to exhibit "good value" for the money for the public health-care system based on sound economic data from health-economic studies. The purpose of this article is to elucidate a framework for health-economic aspects alongside implant trials, with the assumption that the new implant is more costly but potentially better than the control implant. Cost-effectiveness, cost-utility, and cost-benefit studies are suitable for the assessment of the health-economic value of a new implant. The following criteria should be considered for a health-economic study design in the context with an implant: i) it should state medical benefits of the new implant compared with the control implant; ii) it should precise the type of health economic study; iii) it should define the methodological approach, perspective of the study, and types of costs; iv) if necessary, it should state discount costs and/benefits; and v) a sound sensitivity analysis should be included. Furthermore, close cooperation between researchers, clinicians, and health economists is essential.

  15. Evaluation and Design of Downhole Heat Exchangers for Direct Application

    Energy Technology Data Exchange (ETDEWEB)

    Culver, G [Oregon Institute of Technology, Klamath Falls, Oregon; Reistad, G M [Oregon State University, Corvallis, Oregon

    0000-12-30

    Over 400 wells with downhole heat exchangers are in use in Klamath Falls, Oregon. Some have been in use for nearly 30 years. Despite the large number and the long experience, the exact nature of the mechanism of heat exchange and, therefore, the maximum output was not known, except that it had been theorized that convection cells were established in the well. Oregon Institute of Technology and Oregon State University are jointly involved in a project to study the heat exchange process and economics of the downhole heat exchanger system. The existence of significant convection cell circulation has been established and measured using a “spinner,” hot film anemometer, and by energy balance calculations. Based on these measurements, analytical models have been developed which predict heat extraction rates within 15% of actual measured values. The existence of significant mixing of “new” and circulating well fluid has been established and can be calculated, although at this time not accurately predicted before testing a well. Based on the analytical models, multi-tube heat exchangers have been designed and very recently tested with outputs within 15% of predicted values. Economic analyses shows that for small to moderate extraction rates, about 300 kW thermal, and shallow wells, DHEs may be more economical than pumped systems when surface discharge is not acceptable.

  16. Design, Synthesis and Antitumor Evaluation of Novel Pyrazolopyrimidines and Pyrazoloquinazolines

    Directory of Open Access Journals (Sweden)

    Mohamed El-Naggar

    2018-05-01

    Full Text Available A series of N-aryl-7-aryl-pyrazolo[1,5-a]pyrimidines 18a–u and N-aryl-pyrazolo[1,5-a]quinazolines 25a–c were designed and synthesized via the reaction of 5-aminopyrazoles 11a–c with enaminones 12a–g or 19, respectively. The new compounds were screened for their in vitro antitumor activity toward liver (HepG-2 and breast (MCF-7 human cancer cells using 3-[4,5-dimethyl-2-thiazolyl-2,5-diphenyl-2H-tetrazolium bromide MTT assay. From the results, it was found that all compounds showed dose-dependent cytotoxic activities against both HepG-2 and MCF-7 cells. Two compounds 18o and 18a were selected for further investigations. Cell cycle analysis of liver (HepG-2 cells treated with 18o and breast (MCF-7 cells treated with 18a showed cell cycle arrest at G2/M phase and pro-apoptotic activity as indicated by annexin V-FITC staining.

  17. Design, synthesis and fungicidal evaluation of novel pyraclostrobin analogues.

    Science.gov (United States)

    Wang, Lili; Zhao, Shuangshuang; Kong, Xiaotian; Cao, Lingling; Tian, Sheng; Ye, Yonghao; Qiao, Chunhua

    2018-02-15

    A series of novel pyraclostrobin derivatives were designed and prepared as antifungal agents. Their antifungal activities were tested in vitro with five important phytopathogenic fungi, namely, Batrylis cinerea, Phytophthora capsici, Fusarium sulphureum, Gloeosporium pestis and Sclerotinia sclerotiorum using the mycelium growth inhibition method. Among these compounds, 5s displayed IC 50 value of 0.57 μg/mL against Batrylis cinerea and 5k-II displayed IC 50 value of 0.43 μg/mL against Sclerotinia sclerotiorum, which were close to that of the positive control pyraclostrobin (0.18 μg/mL and 0.15 μg/mL). Other compounds 5f, 5k-II, 5j, 5m and 5s also exhibited strong antifungal activity. Further enzymatic assay demonstrated compound 5s inhibited porcine bc 1 complex with IC 50 value of 0.95 μM. The statistical results from an integrated computational pipeline demonstrated the predicted total binding free energy for compound 5s is the highest. Consequently, compound 5s with the biphenyl-4-methoxyl side chain could serve as a new motif as inhibitors of bc 1 complex and deserve to be further investigated. Copyright © 2018 Elsevier Ltd. All rights reserved.

  18. Performance indices and evaluation of algorithms in building energy efficient design optimization

    International Nuclear Information System (INIS)

    Si, Binghui; Tian, Zhichao; Jin, Xing; Zhou, Xin; Tang, Peng; Shi, Xing

    2016-01-01

    Building energy efficient design optimization is an emerging technique that is increasingly being used to design buildings with better overall performance and a particular emphasis on energy efficiency. To achieve building energy efficient design optimization, algorithms are vital to generate new designs and thus drive the design optimization process. Therefore, the performance of algorithms is crucial to achieving effective energy efficient design techniques. This study evaluates algorithms used for building energy efficient design optimization. A set of performance indices, namely, stability, robustness, validity, speed, coverage, and locality, is proposed to evaluate the overall performance of algorithms. A benchmark building and a design optimization problem are also developed. Hooke–Jeeves algorithm, Multi-Objective Genetic Algorithm II, and Multi-Objective Particle Swarm Optimization algorithm are evaluated by using the proposed performance indices and benchmark design problem. Results indicate that no algorithm performs best in all six areas. Therefore, when facing an energy efficient design problem, the algorithm must be carefully selected based on the nature of the problem and the performance indices that matter the most. - Highlights: • Six indices of algorithm performance in building energy optimization are developed. • For each index, its concept is defined and the calculation formulas are proposed. • A benchmark building and benchmark energy efficient design problem are proposed. • The performance of three selected algorithms are evaluated.

  19. Rough Set Theory Based Fuzzy TOPSIS on Serious Game Design Evaluation Framework

    Directory of Open Access Journals (Sweden)

    Chung-Ho Su

    2013-01-01

    Full Text Available This study presents a hybrid methodology for solving the serious game design evaluation in which evaluation criteria are based on meaningful learning, ARCS motivation, cognitive load, and flow theory (MACF by rough set theory (RST and experts’ selection. The purpose of this study tends to develop an evaluation model with RST based fuzzy Delphi-AHP-TOPSIS for MACF characteristics. Fuzzy Delphi method is utilized for selecting the evaluation criteria, Fuzzy AHP is used for analyzing the criteria structure and determining the evaluation weight of criteria, and Fuzzy TOPSIS is applied to determine the sequence of the evaluations. A real case is also used for evaluating the selection of MACF criteria design for four serious games, and both the practice and evaluation of the case could be explained. The results show that the playfulness (C24, skills (C22, attention (C11, and personalized (C35 are determined as the four most important criteria in the MACF selection process. And evaluation results of case study point out that Game 1 has the best score overall (Game 1 > Game 3 > Game 2 > Game 4. Finally, proposed evaluation framework tends to evaluate the effectiveness and the feasibility of the evaluation model and provide design criteria for relevant multimedia game design educators.

  20. Design and Evaluation of a Bacterial Clinical Infectious Diseases Ontology

    Science.gov (United States)

    Gordon, Claire L.; Pouch, Stephanie; Cowell, Lindsay G.; Boland, Mary Regina; Platt, Heather L.; Goldfain, Albert; Weng, Chunhua

    2013-01-01

    With antimicrobial resistance increasing worldwide, there is a great need to use automated antimicrobial decision support systems (ADSSs) to lower antimicrobial resistance rates by promoting appropriate antimicrobial use. However, they are infrequently used mostly because of their poor interoperability with different health information technologies. Ontologies can augment portable ADSSs by providing an explicit knowledge representation for biomedical entities and their relationships, helping to standardize and integrate heterogeneous data resources. We developed a bacterial clinical infectious diseases ontology (BCIDO) using Protégé-OWL. BCIDO defines a controlled terminology for clinical infectious diseases along with domain knowledge commonly used in hospital settings for clinical infectious disease treatment decision-making. BCIDO has 599 classes and 2355 object properties. Terms were imported from or mapped to Systematized Nomenclature of Medicine, Unified Medical Language System, RxNorm and National Center for Bitechnology Information Organismal Classification where possible. Domain expert evaluation using the “laddering” technique, ontology visualization, and clinical notes and scenarios, confirmed the correctness and potential usefulness of BCIDO. PMID:24551353

  1. Novel Carbonyl Analogs of Tamoxifen: Design, Synthesis, and Biological Evaluation

    Directory of Open Access Journals (Sweden)

    Konstantinos M. Kasiotis

    2017-09-01

    Full Text Available Aim of this work was to provide tamoxifen analogs with enhanced estrogen receptor (ER binding affinity. Hence, several derivatives were prepared using an efficient triarylethylenes synthetic protocol. The novel compounds bioactivity was evaluated through the determination of their receptor binding affinity and their agonist/antagonist activity against breast cancer tissue using a MCF-7 cell-based assay. Phenyl esters 6a,b and 8a,b exhibited binding affinity to both ERα and ERβ higher than 4-hydroxytamoxifen while compounds 13 and 14 have shown cellular antiestrogenic activity similar to 4-hydroxytamoxifen and the known ER inhibitor ICI182,780. Theoretical calculations and molecular modeling were applied to investigate, support and explain the biological profile of the new compounds. The relevant data indicated an agreement between calculations and demonstrated biological activity allowing to extract useful structure-activity relationships. Results herein underline that modifications of tamoxifen structure still provide molecules with substantial activity, as portrayed in the inhibition of MCF-7 cells proliferation.

  2. Design and evaluation of Mina: a robotic orthosis for paraplegics.

    Science.gov (United States)

    Neuhaus, Peter D; Noorden, Jerryll H; Craig, Travis J; Torres, Tecalote; Kirschbaum, Justin; Pratt, Jerry E

    2011-01-01

    Mobility options for persons suffering from paraplegia or paraparesis are limited to mainly wheeled devices. There are significant health, psychological, and social consequences related to being confined to a wheelchair. We present the Mina, a robotic orthosis for assisting mobility, which offers a legged mobility option for these persons. Mina is an overground robotic device that is worn on the back and around the legs to provide mobility assistance for people suffering from paraplegia or paraparesis. Mina uses compliant actuation to power the hip and knee joints. For paralyzed users, balance is provided with the assistance of forearm crutches. This paper presents the evaluation of Mina with two paraplegics (SCI ASIA-A). We confirmed that with a few hours of training and practice, Mina is currently able to provide paraplegics walking mobility at speeds of up to 0.20 m/s. We further confirmed that using Mina is not physically taxing and requires little cognitive effort, allowing the user to converse and maintain eye contact while walking. © 2011 IEEE

  3. Design and Biological Evaluation of Antifouling Dihydrostilbene Oxime Hybrids.

    Science.gov (United States)

    Moodie, Lindon W K; Cervin, Gunnar; Trepos, Rozenn; Labriere, Christophe; Hellio, Claire; Pavia, Henrik; Svenson, Johan

    2018-04-01

    By combining the recently reported repelling natural dihydrostilbene scaffold with an oxime moiety found in many marine antifoulants, a library of nine antifouling hybrid compounds was developed and biologically evaluated. The prepared compounds were shown to display a low antifouling effect against marine bacteria but a high potency against the attachment and growth of microalgae down to MIC values of 0.01 μg/mL for the most potent hybrid. The mode of action can be characterized as repelling via a reversible non-toxic biostatic mechanism. Barnacle cyprid larval settlement was also inhibited at low μg/mL concentrations with low levels or no toxicity observed. Several of the prepared compounds performed better than many reported antifouling marine natural products. While several of the prepared compounds are highly active as antifoulants, no apparent synergy is observed by incorporating the oxime functionality into the dihydrostilbene scaffold. This observation is discussed in light of recently reported literature data on related marine natural antifoulants and antifouling hybrids as a potentially general strategy for generation of improved antifoulants.

  4. Analytic evaluation of LAMPF II Booster Cavity design

    International Nuclear Information System (INIS)

    Friedrichs, C.C.

    1985-01-01

    Through the past few decades, a great deal of sophistication has evolved in the numeric codes used to evaluate electromagnetically resonant structures. The numeric methods are extremely precise, even for complicated geometries, whereas analytic methods require a simple uniform geometry and a simple, known mode configuration if the same precision is to be obtained. The code SUPERFISH, which is near the present state-of-the-art of numeric methods, does have the following limitations: No circumferential geometry variations are permissible; there are no provisions for magnetic or dielectric losses; and finally, it is impractical (because of the complexity of the code) to modify it to extract particular bits of data one might want that are not provided by the code as written. This paper describes how SUPERFISH was used as an aid in derivating an analytic model of the LAMPF II Booster Cavity. Once a satisfactory model was derived, simple FORTRAN codes were generated to provide whatever data was required. The analytic model is made up of TEM- and radial-mode transmission-line sections, as well as lumped elements where appropriate. Radial transmission-line equations, which include losses, were not found in any literature, and the extension of the lossless equations to include magnetic and dielectric losses are included in this paper

  5. Design and evaluation of sparse quantization index modulation watermarking schemes

    Science.gov (United States)

    Cornelis, Bruno; Barbarien, Joeri; Dooms, Ann; Munteanu, Adrian; Cornelis, Jan; Schelkens, Peter

    2008-08-01

    In the past decade the use of digital data has increased significantly. The advantages of digital data are, amongst others, easy editing, fast, cheap and cross-platform distribution and compact storage. The most crucial disadvantages are the unauthorized copying and copyright issues, by which authors and license holders can suffer considerable financial losses. Many inexpensive methods are readily available for editing digital data and, unlike analog information, the reproduction in the digital case is simple and robust. Hence, there is great interest in developing technology that helps to protect the integrity of a digital work and the copyrights of its owners. Watermarking, which is the embedding of a signal (known as the watermark) into the original digital data, is one method that has been proposed for the protection of digital media elements such as audio, video and images. In this article, we examine watermarking schemes for still images, based on selective quantization of the coefficients of a wavelet transformed image, i.e. sparse quantization-index modulation (QIM) watermarking. Different grouping schemes for the wavelet coefficients are evaluated and experimentally verified for robustness against several attacks. Wavelet tree-based grouping schemes yield a slightly improved performance over block-based grouping schemes. Additionally, the impact of the deployment of error correction codes on the most promising configurations is examined. The utilization of BCH-codes (Bose, Ray-Chaudhuri, Hocquenghem) results in an improved robustness as long as the capacity of the error codes is not exceeded (cliff-effect).

  6. Novel Carbonyl Analogues of Tamoxifen: Design, Synthesis, and Biological Evaluation

    Science.gov (United States)

    Kasiotis, Konstantinos M.; Lambrinidis, George; Fokialakis, Nikolas; Tzanetou, Evangelia N.; Mikros, Emmanuel; Haroutounian, Serkos A.

    2017-09-01

    Aim of this work was to provide tamoxifen analogues with enhanced estrogen receptor binding affinity. Hence, several derivatives were prepared using an efficient triarylethylenes synthetic protocol. The novel compounds bioactivity was evaluated through the determination of their receptor binding affinity and their agonist/antagonist activity against breast cancer tissue using a MCF-7 cell-based assay. Phenyl esters 6a,b and 8a,b exhibited binding affinity to both ERα and ERβ higher than 4-hydroxytamoxifen while compounds 13 and 14 have shown cellular antiestrogenic activity similar to 4-hydroxytamoxifen and the known estrogen receptor inhibitor ICI182,780. Theoretical calculations and molecular modelling were applied to investigate, support and explain the biological profile of the new compounds. The relevant data indicated an agreement between calculations and demonstrated biological activity allowing to extract useful structure-activity relationships. Results herein underline that modifications of tamoxifen structure still provide molecules with substantial activity, as portrayed in the inhibition of MCF-7 cells proliferation.

  7. Design, Construction and Evaluation of a Row Crop Thinning Machine

    Directory of Open Access Journals (Sweden)

    M Gol Mohammadi

    2014-04-01

    Full Text Available Equipment availability is necessary in the development of Agriculture mechanization. Crop thinning is one of the most important stages in row crop production which is laborious and costly. The objective of this project is design and construction of a row crop thinning machine. Four main system units are plant sensors, ground sensors, control and thinning platforms. In this machine the unwanted plants on the rows are randomly removed by employing a pneumatically system. A blade on a vertical arm with pendulum motion removes the plant from the rows. The machine control system consists of an arm and a blade which is activated by a double acting cylinder and equipped with a relay and a timer. The pneumatic cylinder is controlled via a solenoid valve. Laboratory tests were conducted to validate the machine performance. Some other preliminary tests also were performed for optimization of parameters such as cinematic index and cutting length of blades. The laboratory tests (totally 9 tests were performed with a constant forward speed and three levels of plant density, using artificial plants. The data were analyzed using SPSS software. The results show that satisfactory performance of the machine is achieved when the plant density is moderate i.e. the thinning performance reduces with higher plant distance in the row. The other effective variable on machine performance is the adjustment of sensor sensitivity, which is used to distinguish between week and strong plants. In general the machine performance is sensitive to plant shape and morphology, plant distribution pattern in the field, growing stage of the plants, time of thinning and the effectiveness of previous weeding operations

  8. On public space design for Chinese urban residential area based on integrated architectural physics environment evaluation

    Science.gov (United States)

    Dong, J. Y.; Cheng, W.; Ma, C. P.; Tan, Y. T.; Xin, L. S.

    2017-04-01

    The residential public space is an important part in designing the ecological residence, and a proper physics environment of public space is of greater significance to urban residence in China. Actually, the measure to apply computer aided design software into residential design can effectively avoid an inconformity of design intent with actual using condition, and a negative impact on users due to bad architectural physics environment of buildings, etc. The paper largely adopts a design method of analyzing architectural physics environment of residential public space. By analyzing and evaluating various physics environments, a suitability assessment is obtained for residential public space, thereby guiding the space design.

  9. Linking proteins to signaling pathways for experiment design and evaluation.

    Directory of Open Access Journals (Sweden)

    Illés J Farkas

    Full Text Available Biomedical experimental work often focuses on altering the functions of selected proteins. These changes can hit signaling pathways, and can therefore unexpectedly and non-specifically affect cellular processes. We propose PathwayLinker, an online tool that can provide a first estimate of the possible signaling effects of such changes, e.g., drug or microRNA treatments. PathwayLinker minimizes the users' efforts by integrating protein-protein interaction and signaling pathway data from several sources with statistical significance tests and clear visualization. We demonstrate through three case studies that the developed tool can point out unexpected signaling bias in normal laboratory experiments and identify likely novel signaling proteins among the interactors of known drug targets. In our first case study we show that knockdown of the Caenorhabditis elegans gene cdc-25.1 (meant to avoid progeny may globally affect the signaling system and unexpectedly bias experiments. In the second case study we evaluate the loss-of-function phenotypes of a less known C. elegans gene to predict its function. In the third case study we analyze GJA1, an anti-cancer drug target protein in human, and predict for this protein novel signaling pathway memberships, which may be sources of side effects. Compared to similar services, a major advantage of PathwayLinker is that it drastically reduces the necessary amount of manual literature searches and can be used without a computational background. PathwayLinker is available at http://PathwayLinker.org. Detailed documentation and source code are available at the website.

  10. Augmented Reality for Art, Design and Cultural Heritage—System Design and Evaluation

    Directory of Open Access Journals (Sweden)

    Joachim Rotteveel

    2009-01-01

    Full Text Available This paper describes the design of an optical see-through head-mounted display (HMD system for Augmented Reality (AR. Our goals were to make virtual objects “perfectly” indistinguishable from real objects, wherever the user roams, and to find out to which extent imperfections are hindering applications in art and design. For AR, fast and accurate measuring of head motions is crucial. We made a head-pose tracker for the HMD that uses error-state Kalman filters to fuse data from an inertia tracker with data from a camera that tracks visual markers. This makes on-line head-pose based rendering of dynamic virtual content possible. We measured our system, and found that with an A4-sized marker viewed from >20∘ at 5 m distance with an SXGA camera (FOV 108∘, the RMS error in the tracker angle was <0.5∘ when moving the head slowly. Our Kalman filters suppressed the pose error due to camera delay, which is proportional to the angular and linear velocities, and the dynamic misalignment was comparable to the static misalignment. Applications of artists and designers lead to observations on the profitable use of our AR system. Their exhibitions at world-class museums showed that AR is a powerful tool for disclosing cultural heritage.

  11. A structure-based approach to evaluation product adaptability in adaptable design

    International Nuclear Information System (INIS)

    Cheng, Qiang; Liu, Zhifeng; Cai, Ligang; Zhang, Guojun; Gu, Peihua

    2011-01-01

    Adaptable design, as a new design paradigm, involves creating designs and products that can be easily changed to satisfy different requirements. In this paper, two types of product adaptability are proposed as essential adaptability and behavioral adaptability, and through measuring which respectively a model for product adaptability evaluation is developed. The essential adaptability evaluation proceeds with analyzing the independencies of function requirements and function modules firstly based on axiomatic design, and measuring the adaptability of interfaces secondly with three indices. The behavioral adaptability reflected by the performance of adaptable requirements after adaptation is measured based on Kano model. At last, the effectiveness of the proposed method is demonstrated by an illustrative example of the motherboard of a personal computer. The results show that the method can evaluate and reveal the adaptability of a product in essence, and is of directive significance to improving design and innovative design

  12. User involvement in the design and evaluation of a smart mobility aid.

    Science.gov (United States)

    Lacey, G; MacNamara, S

    2000-01-01

    This paper describes the design and evaluation of an innovative smart mobility aid for the frail visually impaired. The Personal Adaptive Mobility AID (PAM-AID) was developed to address the difficulties in personal mobility of the frail and elderly visually impaired. The paper provides an overview of the PAM-AID research at Trinity College and describes the evolutionary nature of the design process. Because there were no existing systems to guide its development, a series of prototypes was constructed and they were regularly evaluated in the field. This approach views potential users as vital contributing members of the design team and led to rapid and hopefully useful improvements in the design.

  13. User evaluations of design complexity: the impact of visual perceptions for effective online health communication.

    Science.gov (United States)

    Lazard, Allison; Mackert, Michael

    2014-10-01

    This paper highlights the influential role of design complexity for users' first impressions of health websites. An experimental design was utilized to investigate whether a website's level of design complexity impacts user evaluations. An online questionnaire measured the hypothesized impact of design complexity on predictors of message effectiveness. Findings reveal that increased design complexity was positively associated with higher levels of perceived design esthetics, attitude toward the website, perceived message comprehensibility, perceived ease of use, perceived usefulness, perceived message quality, perceived informativeness, and perceived visual informativeness. This research gives further evidence that design complexity should be considered an influential variable for health communicators to effectively reach their audiences, as it embodies the critical first step for message evaluation via electronic platforms. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  14. Evaluation of End-Products in Architecture Design Process: A Fuzzy Decision-Making Model

    Directory of Open Access Journals (Sweden)

    Serkan PALABIYIK

    2012-06-01

    Full Text Available This paper presents a study on the development of a fuzzy multi-criteria decision-making model for the evaluation of end products of the architectural design process. Potentials of the developed model were investigated within the scope of architectural design education, specifically an international design studio titled “Design for Disassembly and Reuse: Design & Building Multipurpose Transformable Pavilions.” The studio work followed a design process that integrated systematic and heuristic thinking. The design objectives and assessment criteria were clearly set out at the beginning of the process by the studio coordinator with the aim of narrowing the design space and increasing awareness of the consequences of design decisions. At the end of the design process, designs produced in the studio were evaluated using the developed model to support decision making. The model facilitated the identification of positive and negative aspects of the designs and selection of the design alternative that best met the studio objectives set at the beginning.

  15. Evaluating the Impact of Design-Driven Requirements Using SysML

    Data.gov (United States)

    National Aeronautics and Space Administration — The proposed research will develop SysML requirements modeling patterns and scripts to automate the evaluation of the impact of design driven requirements....

  16. Design and Evaluation of Chitosan-Based Novel pHSensitive Drug ...

    African Journals Online (AJOL)

    Design and Evaluation of Chitosan-Based Novel pHSensitive Drug Carrier for Sustained ... Scanning electron microscopy(SEM),Raman spectroscopy for particle size analysis. Swelling ratio, Effect of drug loading on encapsulation efficiency

  17. State-of-the-practice : evaluation of sediment basin design, construction, maintenance, and inspection procedures.

    Science.gov (United States)

    2012-08-01

    The following document is the summary of results from a survey that was conducted to evaluate : the state-of-the-practice for sediment basin design, construction, maintenance, and inspection : procedures by State Highway Agencies (SHAs) across the na...

  18. Design and performance evaluation of a hall effect magnetic compass for oceanographic and meteorological applications

    Digital Repository Service at National Institute of Oceanography (India)

    Joseph, A.; Desai, R.G.P.; Agarvadekar, Y.; Tengali, T.; Mishra, M.; Fadate, C.; Gomes, L.

    A Hall Effect magnetic compass, suitable for oceanographic and meteorological applications, has been designed and its performance characteristics have been evaluated. Slope of the least-squares-fitted linear graph was found to be close to the ideal...

  19. Consistent natural phenomena design and evaluation guidelines for U.S. Department of Energy facilities

    International Nuclear Information System (INIS)

    Murray, R.C.; Short, S.A.

    1989-01-01

    Uniform design and evaluation guidelines for protection against natural phenomena hazards such as earthquakes, extreme winds, and flooding for facilities at Department of Energy (DOE) sites throughout the United States have been developed. The guidelines apply to design of new facilities and to evaluation or modification of existing facilities. These guidelines are an approach for design or evaluation for mitigating the effects of natural phenomena hazards. These guidelines are intended to control the level of conservatism introduced in the design/evaluation process such that all hazards are treated on a reasonably consistent and uniform basis and such that the level of conservatism is appropriate for facility characteristics such as importance, cost, and hazards to on-site personnel, the general public, and the environment. The philosophy and goals of these guidelines are covered by this paper

  20. Evaluating Online Dialogue on “Security” Using a Novel Instructional Design

    NARCIS (Netherlands)

    P.A. Arora (Payal)

    2008-01-01

    textabstractAbstract: This paper explores evaluation strategies to gauge the impact of a novel instructional design on international community participation online. This is done by conceptualizing and devising indicators for measuring “engagement” online amongst marginalized adult communities

  1. Evaluating and comparing imaging techniques: a review and classification of study designs

    International Nuclear Information System (INIS)

    Freedman, L.S.

    1987-01-01

    The design of studies to evaluate and compare imaging techniques are reviewed. Thirteen principles for the design of studies of diagnostic accuracy are given. Because of the 'independence principle' these studies are not able directly to evaluate the contribution of a technique to clinical management. For the latter, the 'clinical value' study design is recommended. A classification of study designs is proposed in parallel with the standard classification of clinical trials. Studies of diagnostic accuracy are analogous to Phase II, whereas studies evaluating the contribution to clinical management correspond to the Phase III category. Currently the majority of published studies employ the Phase II design. More emphasis on Phase III studies is required. (author)

  2. Design and evaluation of hybrid wind/PV/diesel power systems for Brazilian applications

    Energy Technology Data Exchange (ETDEWEB)

    McGowan, J.G.; Manwell, J.F.; Avelar, C. [Univ. of Massachusetts, Amherst, MA (United States); Warner, C. [National Renewable Energy Lab., Golden, CO (United States)

    1996-12-31

    This paper presents a summary of a study centered on the design and evaluation of hybrid wind/PV/diesel systems for remote locations in Brazil. The objective of this work was to evaluate high reliability hybrid power systems that have been designed for the lowest life cycle costs. The technical and economic analysis of the hybrid wind/PV/diesel systems was carried out using HYBRID2, a computational code developed at the University of Massachusetts in conjunction with the National Renewable Energy Laboratory (NREL). After a summary of a generalized design procedure for such systems based on the use of this code, a systematic parametric evaluation of a representative design case for a village power system in Brazil is presented. As summarized in the paper, the performance and economic effects of key design parameters are illustrated. 8 refs., 10 figs.

  3. Practical Findings from Applying the PSD Model for Evaluating Software Design Specifications

    Science.gov (United States)

    Räisänen, Teppo; Lehto, Tuomas; Oinas-Kukkonen, Harri

    This paper presents practical findings from applying the PSD model to evaluating the support for persuasive features in software design specifications for a mobile Internet device. On the one hand, our experiences suggest that the PSD model fits relatively well for evaluating design specifications. On the other hand, the model would benefit from more specific heuristics for evaluating each technique to avoid unnecessary subjectivity. Better distinction between the design principles in the social support category would also make the model easier to use. Practitioners who have no theoretical background can apply the PSD model to increase the persuasiveness of the systems they design. The greatest benefit of the PSD model for researchers designing new systems may be achieved when it is applied together with a sound theory, such as the Elaboration Likelihood Model. Using the ELM together with the PSD model, one may increase the chances for attitude change.

  4. Using Vector Projection Method to evaluate maintainability of mechanical system in design review

    International Nuclear Information System (INIS)

    Chen Lu; Cai Jianguo

    2003-01-01

    Maintainability of a mechanical system is one of the system design parameters that has a great impact in terms of ease of maintenance. In this article, based on the definition of the terms of maintenance and maintainability, an important tool of Design for Maintenance is developed as a way to improve maintainability through design. A set of standard and organized guidelines is provided and maintainability factors in terms of physical design, logistics support and ergonomics are identified. As a specific application of design review, a methodology so called Vector Projection Method is developed to evaluate the maintainability of the mechanical system. Lastly, an example is discussed

  5. Rotavirus vaccine effectiveness in low-income settings: An evaluation of the test-negative design

    OpenAIRE

    Schwartz, Lauren M.; Halloran, M. Elizabeth; Rowhani-Rahbar, Ali; Neuzil, Kathleen M.; Victor, John C.

    2017-01-01

    Background The test-negative design (TND), an epidemiologic method currently used to measure rotavirus vaccine (RV) effectiveness, compares the vaccination status of rotavirus-positive cases and rotavirus-negative controls meeting a pre-defined case definition for acute gastroenteritis. Despite the use of this study design in low-income settings, the TND has not been evaluated to measure rotavirus vaccine effectiveness. Methods This study builds upon prior methods to evaluate the use of the T...

  6. Evaluation of a New Dental Implant Cervical Design in Comparison with a Conventional Design in an Experimental American Foxhound Model.

    Science.gov (United States)

    Pérez-Albacete Martínez, Maria Ángeles; Pérez-Albacete Martínez, Carlos; Maté Sánchez De Val, José Eduardo; Ramos Oltra, María Luisa; Fernández Domínguez, Manuel; Calvo Guirado, Jose Luis

    2018-03-21

    The aim of this study was to evaluate osseointegration and crestal bone height in implants with a triangular cervical design in comparison with a standard rounded cervical design. The control group consisted of 24 implants with a standard cervical design, and the test group of 24 implants with a triangular cervical design. The implants were inserted in healed bone in six American Foxhounds. Crestal bone height and tissue thickness in the cervical portion were measured after 12 weeks healing. Data analysis found mean crestal bone loss of: 0.31 ± 0.24 mm on the buccal side, 0.35 ± 0.14 mm on the lingual in the test group, and 0.71 ± 0.28 mm buccal loss, and 0.42 ± 0.30 mm lingual in the control group; with statistically significant differences on the buccal aspect ( p = 0.0019). Mean tissue thickness in the test group was 1.98 ± 0.17 mm on the buccal aspect, and 2.43 ± 0.93 mm in the lingual; in the control group it was 2.48 ± 0.61 mm buccal thickness, and 2.88 ± 0.14 mm lingual, with significant differences on both aspects ( p = 0.0043; p = 0.0029). The results suggest that greater thickness of peri-implant tissue can be expected when the triangular cervical implant design is used rather than the standard cervical design.

  7. Evaluation of a New Dental Implant Cervical Design in Comparison with a Conventional Design in an Experimental American Foxhound Model

    Directory of Open Access Journals (Sweden)

    Maria Ángeles Pérez-Albacete Martínez

    2018-03-01

    Full Text Available The aim of this study was to evaluate osseointegration and crestal bone height in implants with a triangular cervical design in comparison with a standard rounded cervical design. The control group consisted of 24 implants with a standard cervical design, and the test group of 24 implants with a triangular cervical design. The implants were inserted in healed bone in six American Foxhounds. Crestal bone height and tissue thickness in the cervical portion were measured after 12 weeks healing. Data analysis found mean crestal bone loss of: 0.31 ± 0.24 mm on the buccal side, 0.35 ± 0.14 mm on the lingual in the test group, and 0.71 ± 0.28 mm buccal loss, and 0.42 ± 0.30 mm lingual in the control group; with statistically significant differences on the buccal aspect (p = 0.0019. Mean tissue thickness in the test group was 1.98 ± 0.17 mm on the buccal aspect, and 2.43 ± 0.93 mm in the lingual; in the control group it was 2.48 ± 0.61 mm buccal thickness, and 2.88 ± 0.14 mm lingual, with significant differences on both aspects (p = 0.0043; p = 0.0029. The results suggest that greater thickness of peri-implant tissue can be expected when the triangular cervical implant design is used rather than the standard cervical design.

  8. Evaluating cartographic design principles applied to space-time cube content

    DEFF Research Database (Denmark)

    Kveladze, Irma; Kraak, Menno-Jan

    2013-01-01

    the different uses of the graphic variables and depth cues to represent the paths and stations. Both quantitative and qualitative evaluation methods were applied during the testing. The results gave an indication on how design influence the 'performance' of the STC, and resulted in guidelines for the design...... to the neglectance of a proper cartographic design. To judge the influence of this design on the effectiveness and efficiency of the STC as a graphic representation of movement data a user-centered design evaluation has been set up. The experiment included two applications each with its own characteristic data...... complexity and content. It involved a historic and an urban problem case. The first is a relatively simple dataset of historical movements and the second is a complex dataset of pedestrians movement. Based on questions formulated by domain experts different design scenarios were tested. These included...

  9. A lightweight security scheme for wireless body area networks: design, energy evaluation and proposed microprocessor design.

    Science.gov (United States)

    Selimis, Georgios; Huang, Li; Massé, Fabien; Tsekoura, Ioanna; Ashouei, Maryam; Catthoor, Francky; Huisken, Jos; Stuyt, Jan; Dolmans, Guido; Penders, Julien; De Groot, Harmke

    2011-10-01

    In order for wireless body area networks to meet widespread adoption, a number of security implications must be explored to promote and maintain fundamental medical ethical principles and social expectations. As a result, integration of security functionality to sensor nodes is required. Integrating security functionality to a wireless sensor node increases the size of the stored software program in program memory, the required time that the sensor's microprocessor needs to process the data and the wireless network traffic which is exchanged among sensors. This security overhead has dominant impact on the energy dissipation which is strongly related to the lifetime of the sensor, a critical aspect in wireless sensor network (WSN) technology. Strict definition of the security functionality, complete hardware model (microprocessor and radio), WBAN topology and the structure of the medium access control (MAC) frame are required for an accurate estimation of the energy that security introduces into the WBAN. In this work, we define a lightweight security scheme for WBAN, we estimate the additional energy consumption that the security scheme introduces to WBAN based on commercial available off-the-shelf hardware components (microprocessor and radio), the network topology and the MAC frame. Furthermore, we propose a new microcontroller design in order to reduce the energy consumption of the system. Experimental results and comparisons with other works are given.

  10. An Evaluation-Driven Design Approach to Develop Learning Environments Based on Full-Body Interaction

    Science.gov (United States)

    Malinverni, Laura; Schaper, Marie-Monique; Pares, Narcís

    2016-01-01

    The development of learning environments based on full-body interaction has become an increasingly important field of research in recent years. However, the design and evaluation strategies currently used present some significant limitations. Two major shortcomings are: the inadequate involvement of children in the design process and a lack of…

  11. A Computer Environment for Beginners' Learning of Sorting Algorithms: Design and Pilot Evaluation

    Science.gov (United States)

    Kordaki, M.; Miatidis, M.; Kapsampelis, G.

    2008-01-01

    This paper presents the design, features and pilot evaluation study of a web-based environment--the SORTING environment--for the learning of sorting algorithms by secondary level education students. The design of this environment is based on modeling methodology, taking into account modern constructivist and social theories of learning while at…

  12. The Interior Design Simulator. Courseware Evaluation for Vocational and Technical Education.

    Science.gov (United States)

    Worts, Nancy; And Others

    This courseware evaluation rates the Interior Design Simulator program developed by Orange Juice Software Systems. (This program--not contained in this document--allows the user to design a room of any shape with maximum dimensions of 14 x 26 feet.) Part A describes the program in terms of subject area (furniture arrangement) and hardware…

  13. Amail : design and evaluation of an accessible email tool for persons with Aphasia

    NARCIS (Netherlands)

    Mahmud, Al A.; Martens, J.B.O.S.

    2013-01-01

    In this paper, we describe the iterative design and exploratory evaluation of 'Amail', an email tool designed for persons with aphasia. It is inspired by interviews with persons with aphasia and their partners and has been improved through discussions with experienced speech therapists. Our user

  14. Teaching E-Commerce Web Page Evaluation and Design: A Pilot Study Using Tourism Destination Sites

    Science.gov (United States)

    Susser, Bernard; Ariga, Taeko

    2006-01-01

    This study explores a teaching method for improving business students' skills in e-commerce page evaluation and making Web design majors aware of business content issues through cooperative learning. Two groups of female students at a Japanese university studying either tourism or Web page design were assigned tasks that required cooperation to…

  15. INFLUENCE OF DESIGN EVALUATIONS ON DECISION-MAKING AND FEEDBACK DURING CONCEPT DEVELOPMENT

    DEFF Research Database (Denmark)

    Marini, Vinicius Kaster; Ahmed-Kristensen, Saeema; Restrepo-Giraldo, John Dairo

    2011-01-01

    , with the following results: evaluation methods are less than often carried out during conceptual design; failure modes motivating design decisions were repeated over time; and, feedback on robustness and reliability issues is generic when not absent. Recommendations were given to capture designers’ preference...

  16. Designing Preclinical Instruction of Psychomotor Skills (IV)--Instructional Engineering: Evaluation Phase.

    Science.gov (United States)

    Guenzel, Pamela J.; And Others

    1995-01-01

    The fourth article in a four-part series on instructional design discusses evaluation of a psychomotor skills unit taught in preclinical dental education. Issues examined include piloting of instructional materials, analysis and revision of materials based on student performance, syllabus design and content, influence of faculty characteristics,…

  17. Proteus II: Design and Evaluation of an Integrated Power-Efficient Underwater Sensor Node

    NARCIS (Netherlands)

    van Kleunen, W.A.P.; Moseley, N.A.; Havinga, Paul J.M.; Meratnia, Nirvana

    2015-01-01

    We describe the design and evaluation of an integrated low-cost underwater sensor node designed for reconfigurability, allowing continuous operation on a relatively small rechargeable battery for one month. The node uses a host CPU for the network protocols and processing sensor data and a separate

  18. A Tool for the Automated Design and Evaluation of Habitat Interior Layouts

    Science.gov (United States)

    Simon, Matthew A.; Wilhite, Alan W.

    2013-01-01

    The objective of space habitat design is to minimize mass and system size while providing adequate space for all necessary equipment and a functional layout that supports crew health and productivity. Unfortunately, development and evaluation of interior layouts is often ignored during conceptual design because of the subjectivity and long times required using current evaluation methods (e.g., human-in-the-loop mockup tests and in-depth CAD evaluations). Early, more objective assessment could prevent expensive design changes that may increase vehicle mass and compromise functionality. This paper describes a new interior design evaluation method to enable early, structured consideration of habitat interior layouts. This interior layout evaluation method features a comprehensive list of quantifiable habitat layout evaluation criteria, automatic methods to measure these criteria from a geometry model, and application of systems engineering tools and numerical methods to construct a multi-objective value function measuring the overall habitat layout performance. In addition to a detailed description of this method, a C++/OpenGL software tool which has been developed to implement this method is also discussed. This tool leverages geometry modeling coupled with collision detection techniques to identify favorable layouts subject to multiple constraints and objectives (e.g., minimize mass, maximize contiguous habitable volume, maximize task performance, and minimize crew safety risks). Finally, a few habitat layout evaluation examples are described to demonstrate the effectiveness of this method and tool to influence habitat design.

  19. Conceptual Kinematic Design and Performance Evaluation of a Chameleon-Like Service Robot for Space Stations

    Directory of Open Access Journals (Sweden)

    Marco Ceccarelli

    2015-03-01

    Full Text Available In this paper a conceptual kinematic design of a chameleon-like robot with proper mobility capacity is presented for service applications in space stations as result of design considerations with biomimetic inspiration by looking at chameleons. Requirements and characteristics are discussed with the aim to identify design problems and operation features. A study of feasibility is described through performance evaluation by using simulations for a basic operation characterization.

  20. Design and performance evaluation of a cryogenic condenser for an in-pile experiment

    Science.gov (United States)

    Graham, R. W.; Crum, R. J.; Hsu, Y.

    1972-01-01

    An apparatus was designed to enable in-pile irradiation of materials in liquid hydrogen at cryogenic temperatures. One of the principal components of this apparatus was a horizontal tube condenser. The performance of the condenser was evaluated by running a liquid-nitrogen prototype of the apparatus at heat loads comparable to or greater than those expected during the irradiation. The test showed that the condenser was capable of handling the design heat load and that the design procedure was sound.