WorldWideScience

Sample records for design studies progress

  1. Progress in design study on reduced-moderation water reactors

    Energy Technology Data Exchange (ETDEWEB)

    Okubo, Tsutomu; Kugo, Teruhiko; Shimada, Shoichiro; Shirakawa, Toshihisa; Iwamura, Takamichi [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment; Takeda, Renzo [Hitachi Ltd., Tokyo (Japan); Yokoyama, Tsugio [Toshiba Corp., Kawasaki, Kanagawa (Japan); Hibi, Koki [Mitsubishi Heavy Industries Ltd., Tokyo (Japan); Wada, Shigeyuki [Japan Atomic Power Co., Tokyo (Japan)

    2000-06-01

    The Reduced-Moderation Water Reactor (RMWR) is a next generation water-cooled reactor which aims at effective utilization of uranium resource, high burn-up and long operation cycle, and plutonium multi-recycle. These characteristics can be achieved by the high conversion ratio from {sup 238}U to {sup 239}Pu resulted from the higher neutron energy spectrum in comparison to conventional light water reactors. Considering the extension of LWR utilization, Japan Atomic Energy Research Institute (JAERI) started the research on it in 1997 and then started a collaboration in the conceptual design study with the Japan Atomic Power Company (JAPC) in 1998, under technical cooperation with three Japanese reactor vendors. In the core design study of the RMWR, negative void reactivity coefficient is required from a viewpoint of safety as well as establishing hard neutron spectrum. In order to achieve the above trade-off characteristics simultaneously, several basic core design ideas should be combined, such as a tight-lattice fuel assembly, a flat core, a blanket effect, a streaming effect and so on. Up to now, five core concepts have been created for the RMWR as follows: a high conversion BWR type core with high void fraction and super-flat core, a long operation cycle BWR type core using void tube assembly, a high conversion BWR type core without blankets, a high conversion PWR type core using heavy water as a coolant, and a PWR type core for plutonium multi-recycle using seed-blanket type fuel assemblies. Detailed feasibility studies for the RMWR have been continued on core design study. The present report summarizes the recent progress in the design study for the RMWR. (author)

  2. Fusion-driven actinide burner design study. Second quarterly progress report

    International Nuclear Information System (INIS)

    Chi, J.W.H.; Gold, R.E.; Holman, R.R.

    1975-11-01

    The Second Quarterly Progress Report summarizes the status at the mid-point of the conceptual design effort. The fusion driver continues to pose some of the principal design problems due to the necessity of advancing plasma engineering and technology for long pulse, high duty cycle operation. The development of credible design solutions to these problems is one of the major objectives of the study. The TF and OH coil designs have been modified to provide a more compact arrangement in the nose region of the TF coils and to ensure fully cryostable operation. A unique concept has been developed to effectively shield the TF coils from the poloidal fields. A vacuum vessel concept which separates the functions for sustaining the differential pressure load and for sealing the vacuum system is described. The thickness of the blanket has been decreased to reduce the power density and the actinide inventory. Determination and presentation of actinide depletion characteristics represents a major element thus far in the study and is a principal objective. Evaluation of the changes in the hazard only during irradiation proved to be an inadequate measure of the reduction in long term hazards due to the importance of radioactive daughter products which appear much later in time. Therefore, comparisons have been made of long term decay characteristics before and after irradiation in the actinide burner. It has also been noted that some of the actinides that are produced during irradiation have beneficial applications as radioisotopic power sources. These and other considerations suggest that alternate approaches to assessing the waste management problem be considered to develop a meaningful perspective on long term hazards from the actinides

  3. Fusion-driven actinide burner design study. Second quarterly progress report

    Energy Technology Data Exchange (ETDEWEB)

    Chi, J.W.H.; Gold, R.E.; Holman, R.R.

    1975-11-01

    The Second Quarterly Progress Report summarizes the status at the mid-point of the conceptual design effort. The fusion driver continues to pose some of the principal design problems due to the necessity of advancing plasma engineering and technology for long pulse, high duty cycle operation. The development of credible design solutions to these problems is one of the major objectives of the study. The TF and OH coil designs have been modified to provide a more compact arrangement in the nose region of the TF coils and to ensure fully cryostable operation. A unique concept has been developed to effectively shield the TF coils from the poloidal fields. A vacuum vessel concept which separates the functions for sustaining the differential pressure load and for sealing the vacuum system is described. The thickness of the blanket has been decreased to reduce the power density and the actinide inventory. Determination and presentation of actinide depletion characteristics represents a major element thus far in the study and is a principal objective. Evaluation of the changes in the hazard only during irradiation proved to be an inadequate measure of the reduction in long term hazards due to the importance of radioactive daughter products which appear much later in time. Therefore, comparisons have been made of long term decay characteristics before and after irradiation in the actinide burner. It has also been noted that some of the actinides that are produced during irradiation have beneficial applications as radioisotopic power sources. These and other considerations suggest that alternate approaches to assessing the waste management problem be considered to develop a meaningful perspective on long term hazards from the actinides.

  4. Progressive technologies in furniture design

    OpenAIRE

    Šebková, Martina

    2014-01-01

    Šebková, M. Progressive technologies in furniture design. Diploma thesis, Brno, Mendel University in Brno, 2014 Diploma thesis 'Progressive technologies in furniture design' is focused on the use of modern technologies in furniture production. The theoretical part explains the basic terms, technology and material options. It focuses mainly on the production of 3D printed furniture and possibilities of virtual testing, measurements, scanning and rapid prototyping. Practical part of diploma the...

  5. Structured approach to design of diagnostic test evaluation studies for chronic progressive infections in animals

    DEFF Research Database (Denmark)

    Nielsen, Søren Saxmose; Toft, Nils; Gardner, Ian Andrew

    2011-01-01

    Diagnostic test evaluations (DTEs) for chronic infections are challenging because a protracted incubation period has to be considered in the design of the DTE, and the adverse effects of infection may be widespread and progressive over an animal's entire life. Frequently, the specific purpose......) than originally intended. The objective of this paper is to outline a structured approach to the design and conduct of a DTE for diagnostic tests used for chronic infections in animals, and intended for different purposes. We describe the process from reflections about test purpose and the underlying...... of the test is not formally considered when a test is evaluated. Therefore, the result is often a DTE where test sensitivity and specificity estimates are biased, either because of problems with establishing the true infection status or because the test detects another aspect of the infection (and analyte...

  6. The scheme machine: A case study in progress in design derivation at system levels

    Science.gov (United States)

    Johnson, Steven D.

    1995-01-01

    The Scheme Machine is one of several design projects of the Digital Design Derivation group at Indiana University. It differs from the other projects in its focus on issues of system design and its connection to surrounding research in programming language semantics, compiler construction, and programming methodology underway at Indiana and elsewhere. The genesis of the project dates to the early 1980's, when digital design derivation research branched from the surrounding research effort in programming languages. Both branches have continued to develop in parallel, with this particular project serving as a bridge. However, by 1990 there remained little real interaction between the branches and recently we have undertaken to reintegrate them. On the software side, researchers have refined a mathematically rigorous (but not mechanized) treatment starting with the fully abstract semantic definition of Scheme and resulting in an efficient implementation consisting of a compiler and virtual machine model, the latter typically realized with a general purpose microprocessor. The derivation includes a number of sophisticated factorizations and representations and is also deep example of the underlying engineering methodology. The hardware research has created a mechanized algebra supporting the tedious and massive transformations often seen at lower levels of design. This work has progressed to the point that large scale devices, such as processors, can be derived from first-order finite state machine specifications. This is roughly where the language oriented research stops; thus, together, the two efforts establish a thread from the highest levels of abstract specification to detailed digital implementation. The Scheme Machine project challenges hardware derivation research in several ways, although the individual components of the system are of a similar scale to those we have worked with before. The machine has a custom dual-ported memory to support garbage collection

  7. Progress of design studies on an LHD-type steady-state reactor

    International Nuclear Information System (INIS)

    Motojima, O.; Komori, A.; Sagara, A.

    2007-01-01

    Helical Heliotrons such as the Large Helical Device (LHD) and Stellarators (H and S systems) have a high potential to realize a current-less steady-state and stable magnetic fusion energy reactor as an alternative to the tokamak DEMO-reactor. H and S systems ideally have an intrinsic property of Q=infinite. Here it is very important to remember that the understanding of the physics of 3-D toroidal magnetic confinement system is naturally extended to tokamak systems. The physics is universal among these two types of systems and the technology is common. We present our recent results from LHD experiments and reactor studies of a next generation LHD-type DEMO Reactor called FFHR. (1) Development of 3-D superconducting (SC) coil technology Due to the successful results of the LHD construction from 1990 to 2007, and steady operation over 8 years from 1998 to 2007, more than 2,000 hrs/year at a high field of around 3 Tesla, we have a large enough data base to demonstrate that 3D coil technology has become the standard technology for a fusion energy reactor. LHD is the largest SC fusion device in the world, contributing to the development of the SC technology necessary for fusion research. The poloidal coils of LHD adopted a super critical forced flow cooling system and their dimensions are almost the same as the ITER toroidal coils. (2) Extended physics understanding of high beta, high T, high n τT , and steady state operation Recent LHD experiments have demonstrated the broad and advanced capabilities of LHD as a toroidal magnetic confinement device, which are highlighted by the achievements of 5% volume averaged beta, electron and ion temperatures of 10 keV, super high density of 10E15/cc and 1 hr discharges. We plan to increase the heating power up to 35 MW, and to use deuterium gas for confinement improvement. The n τT will be improved to the design nominal value of Q=0.3 within several years and ultimately would approach unity. The key issue for this is the

  8. Recent progress in stellarator reactor conceptual design

    International Nuclear Information System (INIS)

    Miller, R.L.

    1985-01-01

    The Stellarator/Torsatron/Heliotron (S/T/H) class of toroidal magnetic fusion reactor designs continues to offer a distinct and in several ways superior approach to eventual commercial competitiveness. Although no major, integrated conceptual reactor design activity is presently underway, a number of international research efforts suggest avenues for the substantial improvement of the S/T/H reactor embodiment, which derive from recent experimental and theoretical progress and are responsive to current trends in fusion-reactor projection to set the stage for a third generation of designs. Recent S/T/H reactor design activity is reviewed and the impact of the changing technical and programmatic context on the direction of future S/T/H reactor design studies is outlined

  9. Design progress of HYPER system

    International Nuclear Information System (INIS)

    Park, Won S.; Hwang, Woan; Kim, Yong H.; Nam-Il Tak; Song, Tae Y.

    2001-01-01

    Korea Atomic Energy Research Institute (KAERI) has been performing accelerator driven system related research and development called HYPER for the transmutation of nuclear waste and energy production through the transmutation process. HYPER program is within the framework of the national mid and long-term nuclear research plan. KAERI is aiming to develop the system concept and a type of roadmap by the year of 2001 and complete the conceptual design of HYPER system by the year 2006. Some major design features of HYPER system have been developed. Burnable poison concept is being developed to keep the core reactivity swing less than 10%. In order to increase the proliferation resistance, a pyrochemical process is employed for the separation. The trade-off studies for the fuel fabrication are being performed. A dispersion type is believed to have advantages in terms of achieving high discharge burnup. The long-lived fission products such as Tc-99 and I-129 will be destroyed using the localized thermal neutrons separately in the HYPER. A calcium hydride is employed as moderator. SSC-H(Super System Code-HYPER) is being developed to simulate the behavior of coolant systems. The thermal hydraulic properties of Pb-Bi are implemented to SSC-H. The design optimization of target and beam window is performed using FLUENT and ANSYS computer codes. In addition, beam irradiation test is performed to estimate the hardness of window material (9Cr-2WVTa) due to the proton using KeV order accelerator. Beam diameter and window thickness are optimized based on the simulation results. (author)

  10. Study design and baseline findings from the progression of ocular findings (PROOF) natural history study of dry eye.

    Science.gov (United States)

    McDonnell, Peter J; Pflugfelder, Stephen C; Stern, Michael E; Hardten, David R; Conway, Taryn; Villanueva, Linda; Hollander, David A

    2017-12-28

    The aim of this research is to initiate a 5-year natural history study of dry eye disease (DED) using objectively assessed and patient-reported outcomes, to explore the hypothesis that DED is a progressive condition that has substantive and measurable impacts not only on the ocular surface, but on quality of life and visual functioning. Our objective for this report is to examine the baseline data. A multicenter, prospective, controlled, observational study of Level 2 (mild-to-moderate) DED patients based on International Task Force Delphi Panel severity grading, and controls, documented baseline measures (including tear film biomarkers and quality of life). Tear cytokine concentrations were also measured in the tear film. Patients were using artificial tears as needed. Two hundred seventeen DED patients and 67 gender- and age-matched controls were enrolled. A majority were females and Caucasian and groups did not differ significantly in terms of gender, race, or age. Differences between DED and matched controls, at baseline, included mean scores for Ocular Surface Disease Index (31.7 vs 4.1, P eye care practitioners in mild to moderate DED patients compared to normal subjects of similar ages and genders. ClinicalTrials.gov NCT00833235 on January 30, 2009.

  11. Progress on HELIAS systems studies

    Energy Technology Data Exchange (ETDEWEB)

    Warmer, Felix; Beidler, Craig D.; Dinklage, Andreas; Feng, Yuehe; Geiger, Joachim; Schauer, Felix; Turkin, Yuriy; Wolf, Robert; Xanthopoulos, Pavlos [Max-Planck-Institut fuer Plasmaphysik, D-17491 Greifswald (Germany); Kemp, Richard; Knight, Peter; Ward, David [Culham Centre for Fusion Energy, Abingdon, Oxfordshire, OX14 3DB (United Kingdom)

    2015-05-01

    In order to study and design next-step fusion devices such as DEMO, comprehensive systems codes are commonly employed. For the HELIAS-line, stellarator-specific models have been developed, implemented, and verified within the systems code PROCESS. This systems code ansatz is complemented by self-consistent modeling of plasma scenarios employing a predictive 1-D neoclassical transport code which has been augmented with a model for the edge anomalous transport based on 3-D ITG turbulence simulations. This approach is investigated to ultimately allow one to conduct stellarator system studies, develop design points of HELIAS burning plasma devices, and to facilitate a direct comparison between tokamak and stellarator DEMO and power plant designs. The work reports on the progress towards these goals.

  12. International Study Group Progress Report

    Energy Technology Data Exchange (ETDEWEB)

    Raubenheimer, Tor O

    2000-07-18

    The focus of the ISG work was on advancing the accelerator design and supporting technologies. This is a complex process which involves a close interaction between theoretical analysis of the collider design and R and D progress on hardware components. The sequence of efforts took place roughly in the following order: (1) Optimization of the collider parameters and definition of system and subsystem requirements, (2) Identification of design strategies and options, and (3) Development of specific technologies to achieve these requirements. Development and testing of the required components, and R and D on manufacturing techniques have been important activities of the ISG. Experiments at the major test facilities such as the ATF at KEK and ASSET at SLAC have also played a significant role in the ISG studies.

  13. Evaluating progressive-rendering algorithms in appearance design tasks.

    Science.gov (United States)

    Jiawei Ou; Karlik, Ondrej; Křivánek, Jaroslav; Pellacini, Fabio

    2013-01-01

    Progressive rendering is becoming a popular alternative to precomputational approaches to appearance design. However, progressive algorithms create images exhibiting visual artifacts at early stages. A user study investigated these artifacts' effects on user performance in appearance design tasks. Novice and expert subjects performed lighting and material editing tasks with four algorithms: random path tracing, quasirandom path tracing, progressive photon mapping, and virtual-point-light rendering. Both the novices and experts strongly preferred path tracing to progressive photon mapping and virtual-point-light rendering. None of the participants preferred random path tracing to quasirandom path tracing or vice versa; the same situation held between progressive photon mapping and virtual-point-light rendering. The user workflow didn’t differ significantly with the four algorithms. The Web Extras include a video showing how four progressive-rendering algorithms converged (at http://youtu.be/ck-Gevl1e9s), the source code used, and other supplementary materials.

  14. Parametric study of variation in cargo-airplane performance related to progression from current to spanloader designs

    Science.gov (United States)

    Toll, T. A.

    1980-01-01

    A parametric analysis was made to investigate the relationship between current cargo airplanes and possible future designs that may differ greatly in both size and configuration. The method makes use of empirical scaling laws developed from statistical studies of data from current and advanced airplanes and, in addition, accounts for payload density, effects of span distributed load, and variations in tail area ratio. The method is believed to be particularly useful for exploratory studies of design and technology options for large airplanes. The analysis predicts somewhat more favorable variations of the ratios of payload to gross weight and block fuel to payload as the airplane size is increased than has been generally understood from interpretations of the cube-square law. In terms of these same ratios, large all wing (spanloader) designs show an advantage over wing-fuselage designs.

  15. Progress in design of the SNS linac

    International Nuclear Information System (INIS)

    Hardekopf, R.

    2001-01-01

    The Spallation Neutron Source (SNS) is a six-laboratory collaboration to build an intense pulsed neutron facility at Oak Ridge, TN. The linac design has evolved from the conceptual design presented in 1997 in order to achieve higher initial performance and to incorporate desirable upgrade features. The linac is now designed to produce 2-MW beam power using a combination of radio-frequency quadrupole (RFQ) linac, drift-tube linac (DTL), coupled-cavity linac (CCL), and superconducting-RF (SRF) linac. Designs of each of these elements support he high peak intensity and high quality beam required for injection into the SNS accumulator ring. This paper will trace the evolution of the linac design and the progress made in the R and D program. (author)

  16. Designation differences and academic career progression

    Directory of Open Access Journals (Sweden)

    Chris W. Callaghan

    2015-05-01

    Contribution/Value add: This study provides new insights into certain ‘crisis milestones’, or role conflicts or issues, that may need to be resolved or balanced before the career progression of academics can typically occur.

  17. Hybrid antibiotics - clinical progress and novel designs.

    Science.gov (United States)

    Parkes, Alastair L; Yule, Ian A

    2016-07-01

    There is a growing need for new antibacterial agents, but success in development of antibiotics in recent years has been limited. This has led researchers to investigate novel approaches to finding compounds that are effective against multi-drug resistant bacteria, and that delay onset of resistance. One such strategy has been to link antibiotics to produce hybrids designed to overcome resistance mechanisms. The concept of dual-acting hybrid antibiotics was introduced and reviewed in this journal in 2010. In the present review the authors sought to discover how clinical candidates described had progressed, and to examine how the field has developed. In three sections the authors cover the clinical progress of hybrid antibiotics, novel agents produced from hybridisation of two or more small-molecule antibiotics, and novel agents produced from hybridisation of antibiotics with small-molecules that have complementary activity. Many key questions regarding dual-acting hybrid antibiotics remain to be answered, and the proposed benefits of this approach are yet to be demonstrated. While Cadazolid in particular continues to progress in the clinic, suggesting that there is promise in hybridisation through covalent linkage, it may be that properties other than antibacterial activity are key when choosing a partner molecule.

  18. Progresses in proton radioactivity studies

    Energy Technology Data Exchange (ETDEWEB)

    Ferreira, L. S., E-mail: flidia@ist.utl.pt [Center of Physics and Engineering of Advanced Materials, CeFEMA and Departamento de Física, Instituto Superior Técnico, Universidade de Lisboa, Avenida Rovisco Pais, P1049-001 Lisbon (Portugal); Maglione, E. [Dipartimento di Fisica e Astronomia “G. Galilei”, Via Marzolo 8, I-35131 Padova, Italy and Istituto Nazionale di Fisica Nucleare, Padova (Italy)

    2016-07-07

    In the present talk, we will discuss recent progresses in the theoretical study of proton radioactivity and their impact on the present understanding of nuclear structure at the extremes of proton stability.

  19. Progress report on LOFT rake designs

    International Nuclear Information System (INIS)

    Bearden, R.G.

    1977-01-01

    Evaluation of data from Loss-of-Fluid Test (LOFT) nonnuclear tests has shown a need for profile measurements at several locations in the LOFT piping. A prototype rake consisting of three Drag-Disc Turbine Transducers (DTT) has been designed and fabricated for installation at one location (FE-BL-1) in the blowdown loop. After successful operation during a LOFT nonnuclear test (L1-4) scheduled for May, 1977, additional rakes will be installed in the primary and blowdown loops. A research program to develop a pitot tube rake for measurement of steady state and transient two-phase flows is in progress at McMaster University, Hamilton, Ontario. A rake of thermocouples and pitot tubes will be developed for installation near the emergency core coolant (ECC) injection points

  20. Sensitivity of measuring the progress in financial risk protection to survey design and its socioeconomic and demographic determinants: A case study in Rwanda.

    Science.gov (United States)

    Lu, Chunling; Liu, Kai; Li, Lingling; Yang, Yuhong

    2017-04-01

    Reliable and comparable information on households with catastrophic health expenditure (HCHE) is crucial for monitoring and evaluating our progress towards achieving universal financial risk protection. This study aims to investigate the sensitivity of measuring the progress in financial risk protection to survey design and its socioeconomic and demographic determinants. Using the Rwanda Integrated Living Conditions Survey in 2005 and 2010/2011, we derived the level and trend of the percentage of the HCHE using out-of-pocket health spending data derived from (1) a health module with a two-week recall period and six (2005)/seven (2010/2011) survey questions (Method 1) and (2) a consumption module with a four-week/ten-/12-month recall period and 11(2005)/24 (2010/2011) questions (Method 2). Using multilevel logistic regression analysis, we investigated the household socioeconomic and demographic characteristics that affected the sensitivity of estimating the HCHE to survey design. We found that Method 1 generated a significantly higher HCHE estimate (9.2%, 95% confidence interval 8.4%-10.0%) than Method2 (7.4%, 6.6%-8.1%) in 2005 and lower estimate (5.6%, 5.2%-6.1%) than Method 2 (8.2%, 7.6%-8.7%) in 2010/2011. The estimated trends of the HCHE using the two methods were not consistent between the two years. A household's size, its income quintile, having no under-five children, and educational level of its head were positively associated with the consistency of its HCHE status when using the two survey methods. Estimates of the progress in financial risk protection, especially among the most vulnerable households, are sensitive to survey design. These results are robust to various thresholds of catastrophic health spending. Future work must focus on mitigating survey effects through the development of statistical tools. Copyright © 2017 Elsevier Ltd. All rights reserved.

  1. Design and development of progressive tool for manufacturing washer

    Science.gov (United States)

    Annigeri, Ulhas K.; Raghavendra Ravi Kiran, K.; Deepthi, Y. P.

    2017-07-01

    In a progressive tool the raw material is worked at different station to finally fabricate the component. A progressive tool is a lucrative tool for mass production of components. A lot of automobile and other transport industries develop progressive tool for the production of components. The design of tool involves lot of planning and the same amount of skill of process planning is required in the fabrication of the tool. The design also involves use of thumb rules and standard elements as per experience gained in practice. Manufacturing the press tool is a laborious task as special jigs and fixtures have to be designed for the purpose. Assembly of all the press tool elements is another task where use of accurate measuring instruments for alignment of various tool elements is important. In the present study, design and fabrication of progressive press tool for production of washer has been developed and the press tool has been tried out on a mechanical type of press. The components produced are to dimensions.

  2. The Natural History of the Progression of Atrophy Secondary to Stargardt Disease (ProgStar) Studies: Design and Baseline Characteristics: ProgStar Report No. 1.

    Science.gov (United States)

    Strauss, Rupert W; Ho, Alex; Muñoz, Beatriz; Cideciyan, Artur V; Sahel, José-Alain; Sunness, Janet S; Birch, David G; Bernstein, Paul S; Michaelides, Michel; Traboulsi, Elias I; Zrenner, Eberhart; Sadda, SriniVas; Ervin, Ann-Margret; West, Sheila; Scholl, Hendrik P N

    2016-04-01

    To describe the design and baseline characteristics of patients enrolled into 2 natural history studies of Stargardt disease (STGD1). Multicenter retrospective and prospective cohort studies. Three hundred sixty-five unique patients aged 6 years and older at baseline harboring disease-causing variants in the ABCA4 gene and with specified ocular lesions were enrolled from 9 centers in the United States and Europe. In the retrospective study, patients contributed medical record data from at least 2 and up to 4 visits for at least 1 examination modality: fundus autofluorescence (FAF), spectral-domain (SD) optical coherence tomography (SD OCT), and/or microperimetry (MP). The total observational period was at least 2 years and up to 5 years between single visits. Demographic and visual acuity (VA) data also were obtained. In the prospective study, eligible patients were examined at baseline using a standard protocol, with 6-month follow-up visits planned for a 2-year period for serial Early Treatment Diabetic Retinopathy Study (ETDRS) best-corrected VA, SD OCT, FAF, and MP. Design and rationale of a multicenter study to determine the progression of STGD1 in 2 large retrospective and prospective international cohorts. Detailed baseline characteristics of both cohorts are presented, including demographics, and structural and functional retinal metrics. Into the retrospective study, 251 patients (458 eyes) were enrolled; mean follow-up ± standard deviation was 3.9±1.6 years. At baseline, 36% had no or mild VA loss, and 47% of the study eyes had areas of definitely decreased autofluorescence (DDAF) with an average lesion area of 2.5±2.9 mm(2) (range, 0.02-16.03 mm(2)). Two hundred fifty-nine patients (489 eyes) were enrolled in the prospective study. At baseline, 20% had no or mild VA loss, and 64% had areas of DDAF with an average lesion area of 4.0±4.4 mm(2) (range, 0.03-24.24 mm(2)). The mean retinal sensitivity with MP was 10.8±5.0 dB. The ProgStar cohorts have

  3. Design and conduct of Caudwell Xtreme Everest: an observational cohort study of variation in human adaptation to progressive environmental hypoxia

    NARCIS (Netherlands)

    Levett, Denny Z. H.; Martin, Daniel S.; Wilson, Mark H.; Mitchell, Kay; Dhillon, Sundeep; Rigat, Fabio; Montgomery, Hugh E.; Mythen, Monty G.; Grocott, Michael P. W.; Ahuja, V.; Aref-Adib, G.; Burnham, R.; Chisholm, A.; Clarke, K.; Coates, D.; Coates, M.; Cook, D.; Cox, M.; Dhillon, S.; Dougall, C.; Doyle, P.; Duncan, P.; Edsell, M.; Edwards, L.; Evans, L.; Gardiner, P.; Grocott, M.; Gunning, P.; Hart, N.; Harrington, J.; Harvey, J.; Holloway, C.; Howard, D.; Hurlbut, D.; Imray, C.; Ince, C.; Jonas, M.; van der Kaaij, J.; Khosravi, M.; Kolfschoten, N.; Levett, D.; Luery, H.; Luks, A.; Martin, D.; McMorrow, R.; Meale, P.; Mitchell, K.; Montgomery, H.; Morgan, G.; Morgan, J.

    2010-01-01

    The physiological responses to hypoxaemia and cellular hypoxia are poorly understood, and inter-individual differences in performance at altitude and outcome in critical illness remain unexplained. We propose a model for exploring adaptation to hypoxia in the critically ill: the study of healthy

  4. Assessment on the Prevention of Progression by Rosiglitazone on Atherosclerosis in diabetes patients with Cardiovascular History (APPROACH): study design and baseline characteristics.

    Science.gov (United States)

    Ratner, Robert E; Cannon, Christopher P; Gerstein, Hertzel C; Nesto, Richard W; Serruys, Patrick W; Van Es, Gerrit-Anne; Kolatkar, Nikheel S; Kravitz, Barbara G; Zalewski, Andrew; Fitzgerald, Peter J

    2008-12-01

    Rosiglitazone, a thiazolidinedione, has effects on insulin sensitivity and cardiovascular risk factors that may favorably impact the progression of coronary atherosclerosis. APPROACH is a double-blind randomized clinical trial comparing the effects of the insulin sensitizer rosiglitazone with the insulin secretagogue glipizide on the progression of coronary atherosclerosis. Patients with type 2 diabetes and coronary artery disease undergoing clinically indicated coronary angiography or percutaneous coronary intervention are randomized to receive rosiglitazone or glipizide for 18 months using a titration algorithm designed to provide comparable glycemic control between treatment groups. The primary end point is change in percent atheroma volume from baseline to study completion in a nonintervened coronary artery, as measured by intravascular ultrasound. Cardiovascular events are adjudicated by an end point committee. A total of 672 patients were randomized. The mean age was 61 years, hemoglobin A(1c) (HbA(1c)) 7.2%, body mass index 29.5 kg/m(2), and median duration of diabetes 4.8 years. At baseline, approximately half of the participants were receiving oral antidiabetic monotherapy (53.9%) with 27.5% receiving dual combination therapy and 17.9% treated with diet and exercise alone. Approximately two thirds of the participants (68%) had dyslipidemia, 79.9% hypertension, and 24% prior myocardial infarction. APPROACH has fully enrolled a high-risk patient population and will compare the glucose-independent effects of rosiglitazone and glipizide on the progression of coronary atherosclerosis, as well as provide additional data on the cardiovascular safety of rosiglitazone in patients with type 2 diabetes and coronary artery disease.

  5. Challenges and progress in turbomachinery design systems

    International Nuclear Information System (INIS)

    Van den Braembussche, R A

    2013-01-01

    This paper first describes the requirements that a modern design system should meet, followed by a comparison between design systems based on inverse design or optimization techniques. The second part of the paper presents the way these challenges are realized in an optimization method combining an Evolutionary theory and a Metamodel. Extensions to multi-disciplinary, multi-point and multi-objective optimization are illustrated by examples

  6. Preliminary Design Progress of the HCCR TBM for ITER testing

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Dong Won; Park, Sung Dae; Kim, Dong Jun; Jin, Hyung Gon [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Ahn, Mu-Young [National Fusion Research Institute, Daejeon (Korea, Republic of)

    2016-10-15

    Korea has designed a helium cooled ceramic reflector (HCCR) test blanket module (TBM) including the TBM-shield, which is called the TBM-set, to be tested in ITER, a Nuclear Facility INB-174. Through the conceptual design review (CDR), its design integrity was successfully demonstrated at the conceptual design level at various loads. After CD approval, preliminary design (PD) was started and the progress is introduced in the present study. After PD review and approval, final design and then fabrication will be started. The main purpose of PD is to design the TBM-set according to the fabrication aspect and more detailed design for interfaces with ITER machine, such as installed TBM port plug and frame. With these considering, PD of TBM-set was started. PD for HCCR TBM has been performed (so far v0.24) from the CD model. FW, BZ, SW, TES/NAS, BM, and connecting support design were performed through the analyses, if necessary. The manufacturability was the main concern for PD model development. Thermal hydraulic analysis will be performed to evaluate the temperature and pressure drop in TBM-set. The structural integrity of TBM-set will be confirmed with combined various loads condition.

  7. Progress on traveling-wave reactor design

    International Nuclear Information System (INIS)

    Gilleland, John

    2009-01-01

    TerraPower LLC is leading a collaborative effort to develop physics and engineering designs for several kinds of sodium-cooled traveling-wave reactors. This collaboration includes nuclear engineering groups at TerraPower, M.I.T., U.N.L.V., Argonne National Laboratory, and the Columbia River Basin Consulting Group, as well as individual consultants from Lawrence Livermore National Laboratory, U.C. Berkeley, and several other institutions. The goal of this initiative is to develop innovative technologies that will enable cost-effective breed-and-burn reactors, which produce electricity from fuel composed almost wholly of depleted uranium. We will present conceptual designs ranging in reactor vessel size from five meters to 13 meters and in output from about 100 MWe to more than 1,000 MWe. Our Monte Carlo simulations for these reactors predict refueling intervals ranging from 40 to 125 years. Scaling designs from small to large sizes requires a shift in basic design approach; lessons learned from this effort will be discussed. We will also share our evolving understanding of the ways in which the core design can be simplified by improvements to certain limiting technologies. (author)

  8. Accelerator research studies. Progress report

    International Nuclear Information System (INIS)

    1984-06-01

    Progress is reported in both experimental studies as well as theoretical understanding of the beam transport problem. Major highlights are: (a) the completion of the first channel section with 12 periods and two matching solenoids, (b) measurements of beam transmission and emittance in this 12-lens channel, (c) extensive analytical and numerical studies of the beam transport problem in collaboration with GSI (W. Germany), (d) detailed measurements and calculations of beam propagation through one lens with spherical aberration and space charge, and (e) completion of the emittance grids at the Rutherford-Appleton Laboratory. Our main objectives in Task B of our research program are: (a) study of collective acceleration of positive ions from a localized plasma source by an intense relativistic electron beam (IREB), (b) external control of the IREB beam front by a slow-wave structure to achieve higher ion energies - the Beam Front Accelerator (BFA) concept, (c) study of ion and electron acceleration and other applications of a plasma focus device, and (d) theoretical studies in support of (a) and (b). Our research in these areas has been oriented towards obtaining an improved understanding of the physical processes at work in these experiments and, subsequently, achieving improved performance for specific potential applications

  9. Educational Design Research: Signs of Progress

    Science.gov (United States)

    Reeves, Thomas C.

    2015-01-01

    This special issue of the "Australasian Journal of Educational Technology" includes an introductory article by the guest editors and six papers that illustrate the potential of educational design research (EDR) to address important problems in higher education. In this final paper, reflections on the papers are made. Then the rationale…

  10. Development of a SIMSMART Based, Progressive Flooding Design Tool

    National Research Council Canada - National Science Library

    Anderson, Thomas

    1999-01-01

    While the Navy addresses the effects of progressive flooding in its design requirements, its limits for damaged stability are the results of World War II damage analysis and are evaluated under static...

  11. Design progress of the ITER vacuum vessel sectors and port structures

    International Nuclear Information System (INIS)

    Utin, Yu.; Ioki, K.; Alekseev, A.; Bachmann, Ch.; Cho, S.; Chuyanov, V.; Jones, L.; Kuzmin, E.; Morimoto, M.; Nakahira, M.; Sannazzaro, G.

    2007-01-01

    Recent progress of the ITER vacuum vessel (VV) design is presented. As the ITER construction phase approaches, the VV design has been improved and developed in more detail with the focus on better performance, improved manufacture and reduced cost. Based on achievements of manufacturing studies, design improvement of the typical VV Sector (no. 1) has been nearly finalized. Design improvement of other sectors is in progress-in particular, of the VV Sectors no. 2 and no. 3 which interface with tangential ports for the neutral beam (NB) injection. For all sectors, the concept for the in-wall shielding has progressed and developed in more detail. The design progress of the VV sectors has been accompanied by the progress of the port structures. In particular, design of the NB ports was advanced with the focus on the beam-facing components to handle the heat input of the neutral beams. Structural analyses have been performed to validate all design improvements

  12. Accelerator research studies: Progress report, Task C

    International Nuclear Information System (INIS)

    1985-06-01

    The major effort reported is the study of the feasibility of a 300 MW gyroklystron at ∼9 GHz, and substantial progress has been made. A four-cavity gyroklystron design has been shown to be capable of linear gain as high as 66 dB and to be marginally stable against oscillation in any mode. AM and PM sensitivities to fluctuation in system parameters have also been calculated in the regime of linear operation. Initial non-linear design calculations have also been carried out which include the effect of tapering the axial magnetic guide field over the length of a gyroklystron circuit. Although these calculations are preliminary they do indicate potential for significant efficiency enhancement by magnetic field shaping techniques

  13. Nuclear challenges and progress in designing stellarator fusion power plants

    International Nuclear Information System (INIS)

    El-Guebaly, L.A.; Wilson, P.; Henderson, D.; Sawan, M.; Sviatoslavsky, G.; Tautges, T.; Slaybaugh, R.; Kiedrowski, B.; Ibrahim, A.

    2008-01-01

    Over the past 5-6 decades, stellarator power plants have been studied in the US, Europe, and Japan as an alternate to the mainline magnetic fusion tokamaks, offering steady-state operation and eliminating the risk of plasma disruptions. The earlier 1980s studies suggested large-scale stellarator power plants with an average major radius exceeding 20 m. The most recent development of the compact stellarator concept delivered ARIES-CS - a compact stellarator with 7.75 m average major radius, approaching that of tokamaks. For stellarators, the most important engineering parameter that determines the machine size and cost is the minimum distance between the plasma boundary and mid-coil. Accommodating the breeding blanket and necessary shield within this distance to protect the ARIES-CS superconducting magnet represents a challenging task. Selecting the ARIES-CS nuclear and engineering parameters to produce an economic optimum, modeling the complex geometry for 3D nuclear analysis to confirm the key parameters, and minimizing the radwaste stream received considerable attention during the design process. These engineering design elements combined with advanced physics helped enable the compact stellarator to be a viable concept. This paper provides a brief historical overview of the progress in designing stellarator power plants and a perspective on the successful integration of the nuclear activity into the final ARIES-CS configuration

  14. Nuclear spectroscopic studies. Progress report

    International Nuclear Information System (INIS)

    Bingham, C.R.; Riedinger, L.L.; Sorensen, S.P.

    1996-01-01

    This report describes progress in the experimental nuclear physics program of the University of Tennessee, Knoxville. It presents findings related to properties of high-spin states, low-energy levels of nuclei far from stability, and high-energy heavy-ion physics, as well as a brief description of the Joint Institute of Heavy Ion Research (a collaboration between the University of Tennessee, Vanderbilt University, and Oak Ridge National Laboratory) and its activities (particularly those of the last few years), and a list of publications. 89 refs., 18 figs., 5 tabs

  15. A Plastic Design Method for RC Moment Frame Buildings against Progressive Collapse

    Directory of Open Access Journals (Sweden)

    Hadi Faghihmaleki

    2017-04-01

    Full Text Available In this study, progressive collapse potential of generic 3-, 8- and 12-storey RC moment frame buildings designed based on IBC-2006 code was investigated by performing non-linear static and dynamic analyses. It was observed that the model structures had high potential for progressive collapse when the second floor column was suddenly removed. Then, the size of beams required to satisfy the failure criteria for progressive collapse was obtained by using the virtual work method; i.e., using the equilibrium of the external work done by gravity load due to loss of a column and the internal work done by plastic rotation of beams. According to the nonlinear dynamic analysis results, the model structures designed only for normal load turned out to have strong potential for progressive collapse whereas the structures designed by plastic design concept for progressive collapse satisfied the failure criterion recommended by the GSA code. 

  16. Design and progress of the SPHINX in KAERI

    International Nuclear Information System (INIS)

    Kim, Hyung Rae; Kim, Hwan Teol; Song, Jin Ho; Kim, Hee Dong; Bae Yoon Yeong

    2005-01-01

    The SCWR (SuperCritical Water-cooled Reactor) is one of the six reactor candidates selected in the Gen-IV project, which aims at the development of new reactors with enhanced economy and safety. The SCWR is considered to be a feasible concept of new nuclear power plant if the existing technologies developed in fossil fuel fired plants and LWRs are incorporated together with additional researches on several disciplines such as materials, water chemistry, and safety. Among the research areas, heat transfer experiments under supercritical conditions are required for the proper prediction of thermal hydraulic phenomena, which are essential in the reactor core designs. A heat transfer test loop using carbon dioxide (CO 2 ) as a surrogate fluid has been constructed in KAERI. The test facility, named as SPHINX (Supercritical Pressure Heat transfer Investigation for NeXt generation), will be used for the study of heat transfer in a single tube, single rod, and rod bundle. The heat transfer correlations obtained from the SPHINX will be compared with the other correlations generated at Kyushu University and INL. This paper describes the design characteristics and progress of the SPHINX in KAERI. The construction of the facility is completed and a trial run is being conducted. The test and the data production are expected to start by April 2005

  17. Design and progress of the SPHINX in KAERI

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Hyung Rae; Kim, Hwan Teol; Song, Jin Ho; Kim, Hee Dong; Bae Yoon Yeong [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    2005-07-01

    The SCWR (SuperCritical Water-cooled Reactor) is one of the six reactor candidates selected in the Gen-IV project, which aims at the development of new reactors with enhanced economy and safety. The SCWR is considered to be a feasible concept of new nuclear power plant if the existing technologies developed in fossil fuel fired plants and LWRs are incorporated together with additional researches on several disciplines such as materials, water chemistry, and safety. Among the research areas, heat transfer experiments under supercritical conditions are required for the proper prediction of thermal hydraulic phenomena, which are essential in the reactor core designs. A heat transfer test loop using carbon dioxide (CO{sub 2}) as a surrogate fluid has been constructed in KAERI. The test facility, named as SPHINX (Supercritical Pressure Heat transfer Investigation for NeXt generation), will be used for the study of heat transfer in a single tube, single rod, and rod bundle. The heat transfer correlations obtained from the SPHINX will be compared with the other correlations generated at Kyushu University and INL. This paper describes the design characteristics and progress of the SPHINX in KAERI. The construction of the facility is completed and a trial run is being conducted. The test and the data production are expected to start by April 2005.

  18. Progress in urban dispersion studies

    DEFF Research Database (Denmark)

    Batchvarova, E.; Gryning, Sven-Erik

    2006-01-01

    The present Study addresses recent achievements in better representation Of the urban area structure in meteorology and dispersion parameterisations. The setup and Main Outcome of several recent dispersion experiments in Urban areas and their use in model validation are discussed. The maximum con...

  19. Fusion Studies Program. Progress report

    International Nuclear Information System (INIS)

    Stacey, W.M. Jr.

    1984-01-01

    Continuation of work in two areas, impurity control and transient electromagnetics, is proposed. In the tokamak impurity control area, an innovative supplemental mechanism, NB-driven impurity flow reversal, has been developed partly under this contract; and the proposed effort is aimed at completing this development, verifying the methodology by comparison with experiment and evaluating its potential in future tokamak experiments. In the tokamak transient electromagnetics area, the proposed effort is aimed at developing a new and more efficient methodology for calculating the currents and resulting magnetic fields in the torus structure and coil systems, which will allow a detailed representation of the latter that can be coupled to the distributed-current plasma model that was implemented for vertical stability and disruption control studies in previous work under this contract; and the application of this methodology to study the control of vertical instabilities and disruptions

  20. Accelerator research studies. Progress report

    International Nuclear Information System (INIS)

    1983-07-01

    The major goal of this project is to study the effects that lead to emittance growth and limitation of beam current and brightness in periodic focusing systems (including linear accelerators). This problem is of great importance for all accelerator applications requiring high intensity beams with small emittance such as heavy ion fusion, spallation neutron sources and high energy physics. In the latter case, future machines must not only provide higher energies (in the range of 10 to 100 TeV), but also higher luminosities than the existing facilities. This implies considerably higher phase-space density of the particle beam produced by the injector linac, i.e., the detrimental emittance growth and concurrent beam loss observed in existing linacs must be avoided

  1. Nuclear spectroscopic studies. Progress report

    Energy Technology Data Exchange (ETDEWEB)

    Bingham, C.R.; Guidry, M.W.; Riedinger, L.L.; Sorensen, S.P.

    1993-02-08

    The Nuclear Physics group at the University of Tennessee, Knoxville is involved in several aspects of heavy-ion physics including both nuclear structure and reaction mechanisms. While our main emphasis is on experimental problems involving heavy-ion accelerators, we have maintained a strong collaboration with several theorists in order to best pursue the physics of our measurements. During the last year we have led several experiments at the Holifield Heavy Ion Research Facility and participated in others at Argonne National Laboratory. Also, we continue to be very active in the collaboration to study ultra-relativistic heavy ion physics utilizing the SPS accelerator at CERN in Geneva, Switzerland and in a RHIC detector R&D project. Our experimental work is in four broad areas: (1) the structure of nuclei at high angular momentum, (2) heavy-ion induced transfer reactions, (3) the structure of nuclei far from stability, and (4) ultra-relativistic heavy-ion physics. The results of studies in these particular areas will be described in this document in sections IIA, IIB, IIC, and IID, respectively. Areas (1), (3), and (4) concentrate on the structure of nuclear matter in extreme conditions of rotational motion, imbalance of neutrons and protons, or very high temperature and density. Area (2) pursues the transfer of nucleons to states with high angular momentum, both to learn about their structure and to understand the transfer of particles, energy, and angular momentum in collisions between heavy ions. An important component of our program is the strong emphasis on the theoretical aspects of nuclear structure and reactions.

  2. Nuclear spectroscopic studies: Progress report

    International Nuclear Information System (INIS)

    Bingham, C.R.; Guidry, M.W.; Riedinger, L.L.; Sorensen, S.P.

    1989-01-01

    The Nuclear Physics Group at the University of Tennessee, Knoxville (UTK) is involved in several aspects of heavy-ion physics including both nuclear structure and reaction mechanisms. While our main emphasis is on experimental problems involving heavy-ion accelerators, we have maintained a strong collaboration with several theorists in order to best pursue the physics of our measurements. During the last year we have led experiments at the Holifield Heavy Ion Research Facility (HHIRF) and the Niels Bohr Institute Tandem Accelerator. Also, we are active in a collaboration (WA80) to study ultra-relativistic heavy ion physics utilizing the SPS accelerator at CERN in Geneva, Switzerland. Our experimental work is four broad areas: (1) the structure of nuclei at high angular momentum, (2) heavy-ion induced transfer reactions, (3) the structure of nuclei far from stability, and (4) ultra-relativistic heavy-ion physics. These results will be described in this document. Areas (1), (3), and (4) concentrate on the structure of nuclear matter in extreme conditions of rotational motion, imbalance of neutrons and protons, or very high temperature and density. Area (2) pursues the transfer of nucleons to states with high angular momentum, both to learn about their structure and to understand the transfer of particles, energy, and angular momentum in collisions between heavy ions. An important component of our program is the strong emphasis on the theoretical aspects of nuclear structure and reactions

  3. Studies of human mutation rates: Progress report

    International Nuclear Information System (INIS)

    Neel, J.V.

    1988-01-01

    Progress was recorded between January 1 and July 1, 1987 on a project entitled ''Studies of Human Mutation Rates''. Studies underway include methodology for studying mutation at the DNA level, algorithms for automated analyses of two-dimensional polyacrylamide DNA gels, theoretical and applied population genetics, and studies of mutation frequency in A-bomb survivors

  4. Recent progress in computational approaches to studying the M2 proton channel and its implication to drug design against influenza viruses.

    Science.gov (United States)

    Du, Qi-Shi; Huang, Ri-Bo

    2012-05-01

    For quite a long period of time in history, many intense efforts have been made to determine the 3D (three-dimensional) structure of the M2 proton channel. The reason why the M2 proton channel has attracted so many attentions is because (1) it is the key for really understanding the life cycle of influenza viruses, and (2) it is indispensable for conducting rational drug design against the flu viruses. Recently, the long-sough 3D structures of the M2 proton channels for both influenza A and B viruses were consecutively successfully determined by the high-resolution NMR spectroscopy (Schnell J.R. and Chou, J.J., Nature, 2008, 451: 591-595; Wang, J., Pielak, R.M., McClintock, M.A., and Chou, J.J., Nature Structural & Molecular Biology, 2009,16: 1267-1271). Such a milestone work has provided a solid structural basis for in-depth understanding the action mechanism of the M2 channel and rationally designing effective drugs against influenza viruses. This review is devoted to, with the focus on the M2 proton channel of influenza A, addressing a series of relevant problems, such as how to correctly understand the novel allosteric inhibition mechanism inferred from the NMR structure that is completely different from the traditional view, what the possible impacts are to the previous functional studies in this area, and what kind of new strategy can be stimulated for drug development against influenza.

  5. Failure: A Source of Progress in Maintenance and Design

    Science.gov (United States)

    Chaïb, R.; Taleb, M.; Benidir, M.; Verzea, I.; Bellaouar, A.

    This approach, allows using the failure as a source of progress in maintenance and design to detect the most critical components in equipment, to determine the priority order maintenance actions to lead and direct the exploitation procedure towards the most penalizing links in this equipment, even define the necessary changes and recommendations for future improvement. Thus, appreciate the pathological behaviour of the material and increase its availability, even increase its lifespan and improve its future design. In this context and in the light of these points, the failures are important in managing the maintenance function. Indeed, it has become important to understand the phenomena of failure and degradation of equipments in order to establish an appropriate maintenance policy for the rational use of mechanical components and move to the practice of proactive maintenance [1], do maintenance at the design [2].

  6. Progress in octahedral spherical hohlraum study

    Directory of Open Access Journals (Sweden)

    Ke Lan

    2016-01-01

    Full Text Available In this paper, we give a review of our theoretical and experimental progress in octahedral spherical hohlraum study. From our theoretical study, the octahedral spherical hohlraums with 6 Laser Entrance Holes (LEHs of octahedral symmetry have robust high symmetry during the capsule implosion at hohlraum-to-capsule radius ratio larger than 3.7. In addition, the octahedral spherical hohlraums also have potential superiority on low backscattering without supplementary technology. We studied the laser arrangement and constraints of the octahedral spherical hohlraums, and gave a design on the laser arrangement for ignition octahedral hohlraums. As a result, the injection angle of laser beams of 50°–60° was proposed as the optimum candidate range for the octahedral spherical hohlraums. We proposed a novel octahedral spherical hohlraum with cylindrical LEHs and LEH shields, in order to increase the laser coupling efficiency and improve the capsule symmetry and to mitigate the influence of the wall blowoff on laser transport. We studied on the sensitivity of the octahedral spherical hohlraums to random errors and compared the sensitivity among the octahedral spherical hohlraums, the rugby hohlraums and the cylindrical hohlraums, and the results show that the octahedral spherical hohlraums are robust to these random errors while the cylindrical hohlraums are the most sensitive. Up till to now, we have carried out three experiments on the spherical hohlraum with 2 LEHs on Shenguang(SG laser facilities, including demonstration of improving laser transport by using the cylindrical LEHs in the spherical hohlraums, spherical hohlraum energetics on the SGIII prototype laser facility, and comparisons of laser plasma instabilities between the spherical hohlraums and the cylindrical hohlraums on the SGIII laser facility.

  7. Nuclear challenges and progress in designing stellarator power plants

    International Nuclear Information System (INIS)

    El-Guebaly, L.

    2007-01-01

    As an alternate to the mainline magnetic fusion tokamaks, the stellarator concept offers a steady state operation without external driven current, eliminating the risk of plasma irruptions. Over the past 2-3 decades, stellarator power plants have been studied in the U.S., Japan, and Europe to enhance the physics and engineering aspects and optimize the design parameters that are subject to numerous constraints. The earlier 1980's studies delivered large stellarators with an average major radius exceeding 20 m. The most recent development of the compact stellarator concept has led to the construction of the National Compact Stellarator Experiment (NCSX) in the U.S. and the 3 years power plant study of ARIES-CS, a compact stellarator with 7.75 m average major radius, approaching that of tokamaks. The ARIES-CS first wall configuration deviates from the standard practice of uniform toroidal shape in order to achieve compactness. Modeling such a complex geometry for 3-D nuclear analysis was a challenging engineering task. A novel approach based on coupling the CAD model with the MCNP Monte Carlo code was developed to model, for the first time ever, the complex stellarator geometry for nuclear assessments. The most important parameter that determines the stellarator size and cost is the minimum distance between the plasma boundary and mid-coil. Accommodating the breeding blanket and necessary shield to protect the superconducting magnet represented another challenging task. An innovative approach utilizing a non-uniform blanket combined with a highly efficient WC shield for this highly constrained area reduced the radial standoff (and machine size and cost) by 25- 30%, which is significant. As stellarators generate more radwaste than tokamaks, managing ARIES-CS active materials during operation and after plant decommissioning was essential for the environmental attractiveness of the machine. The geological disposal option could be replaced with more attractive scenarios

  8. Design and R and D progress of Korean HCCR TBM

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Seungyon, E-mail: sycho@nfri.re.kr [National Fusion Research Institute, Daejeon (Korea, Republic of); Ahn, Mu-Young [National Fusion Research Institute, Daejeon (Korea, Republic of); Lee, Dong Won [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Park, Yi-Hyun [National Fusion Research Institute, Daejeon (Korea, Republic of); Lee, Eo Hwak; Jin, Hyung Gon; Lee, Cheol Woo; Kim, Tae Kyu; Chun, Young-Bum; Kim, Suk Kwon; Yoon, Jae Sung [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Yun, Young-Hoon [Dongshin University, Naju (Korea, Republic of); Jung, Yang Il [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Lee, Young-Min [National Fusion Research Institute, Daejeon (Korea, Republic of); Shin, Kyu In [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Ku, Duck Young; Park, Soon Chang; Kim, Chang-Shuk; Min, Kyungmi [National Fusion Research Institute, Daejeon (Korea, Republic of); Jeong, Yong Hwan [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); and others

    2014-10-15

    Korea plans to test a Helium Cooled Ceramic Reflector (HCCR) Test Blanket Module (TBM) in ITER. The HCCR TBM adopts a four sub-module concept considering the fabricability and the transfer of irradiated TBM for post irradiation examination. Each sub-module has seven-layer breeding zone, including three neutron multiplier layers packed with beryllium pebbles, three lithium ceramic pebble bed packed tritium breeder layers, and a reflector layer packed with graphite pebbles. Based on this configuration, neutronic and electromagnetic calculations were performed and their results were applied for the conceptual design of HCCR TBM that considers manufacturing feasibility. Also, a design and safety analysis of HCCR Test Blanket System (TBS) was performed using integrated design tools modifying nuclear system codes for helium coolant and tritium behavior evaluation. The Advanced Reduced Activation Alloy (ARAA) is being developed as a structural material. A total of 73 candidate ARAA alloys were designed and their out-of-pile performance was evaluated. The graphite pebbles as the neutron reflector were fabricated by using mechanical machining and grounding method with the surface coated with SiC. The hydrogen permeation characteristics of structural materials were evaluated using the Hydrogen PERmeation (HYPER) facility. The recent design and R and D progress on these areas are addressed in this paper.

  9. Inhibiting the Progression of Arterial Calcification with Vitamin K in HemoDialysis Patients (iPACK-HD Trial: Rationale and Study Design for a Randomized Trial of Vitamin K in Patients with End Stage Kidney Disease

    Directory of Open Access Journals (Sweden)

    Rachel M Holden

    2015-05-01

    Full Text Available Background: Cardiovascular disease, which is due in part to progressive vascular calcification, is the leading cause of death among patients with end stage kidney disease (ESKD on dialysis. A role for vitamin K in the prevention of vascular calcification is plausible based on the presence of vitamin K dependent proteins in vascular tissue, including matrix gla protein (MGP. Evidence from animal models and observational studies support a role for vitamin K in the prevention of vascular calcification. A large-scale study is needed to investigate the effect of vitamin K supplementation on the progression of vascular calcification in patients with ESKD, a group at risk for sub-clinical vitamin K deficiency. Methods/Design: We plan a prospective, randomized, double-blind, multicenter controlled trial of incident ESKD patients on hemodialysis in centers within North America. Eligible subjects with a baseline coronary artery calcium score of greater than or equal to 30 Agatston Units, will be randomly assigned to either the treatment group (10 mg of phylloquinone three times per week or to the control group (placebo administration three times per week. The primary endpoint is the progression of coronary artery calcification defined as a greater than 15% increase in CAC score over baseline after 12 months. Discussion: Vitamin K supplementation is a simple, safe and cost-effective nutritional strategy that can easily be integrated into patient care. If vitamin K reduces the progression of coronary artery calcification it may lead to decreased morbidity and mortality in men and women with ESKD. Trial registration: NCT 01528800.

  10. Progressive Development of Creative Design Skills from Kindergarden Education

    Directory of Open Access Journals (Sweden)

    Meryem Yalcin

    2015-07-01

    Full Text Available This article offers an alternative view of design education, emphasising on its introduction in kindergarten and proposing a curriculum that covers design issues for introduction in kinder­gar­ten. This approach is suited to developing creative thinking skills. In an environ­ment where children imagine, create, practice, modify, recognise, manipulate and share knowl­edge, experiences and objects are crucial in design education. Early childhood education should be advanced based on basic design issues—such as design principles, conceptuali­zation, 2D/3D spatial allocation and composition—more comprehensively, which will enable children to construct perceptual, critical and analytic view points at an early age and develop these perspectives in the future. Based on this argument, the study model for design education in kindergarten, which will instil in children strong design knowledge, as well as stimulate their cognitive development. 

  11. Progress in studies on nucleolus functions

    International Nuclear Information System (INIS)

    Chang Lei; Zhou Guangming

    2011-01-01

    Nucleoli is the sites for ribosome synthesis and processing, however, recent approaches have revealed that it is also involved in variety of cellular processes, especially the cellular stress response. As sensors, nucleoli regulate the localization of nucleolar proteins, such as (Alternate Reading Frame, ARF), and the activation of key factors, such as P53, and consequently mediate the cellular stress response.In this paper, recent progress in the studies on nucleolar functions in cellular stress response to radiation is reviewed. (authors)

  12. Effects of curriculum organisation on study progress in engineering studies

    NARCIS (Netherlands)

    Hulst, M. van der; Jansen, E.

    2002-01-01

    Procrastination and time investment are important issues in the study of student performance and progress. Previous research on these issues has mainly concentrated upon individual differences between students in personality and time management skills. However, study progress depends not only on

  13. Effects of curriculum organisation on study progress in engineering studies

    NARCIS (Netherlands)

    van der Hulst, M.; Jansen, E.P.W.A.

    Procrastination and time investment are important issues in the study of student performance and progress. Previous research on these issues has mainly concentrated upon individual differences between students in personality and time management skills. However, study progress depends not only on

  14. Optimum study designs.

    Science.gov (United States)

    Gu, C; Rao, D C

    2001-01-01

    Because simplistic designs will lead to prohibitively large sample sizes, the optimization of genetic study designs is critical for successfully mapping genes for complex diseases. Creative designs are necessary for detecting and amplifying the usually weak signals for complex traits. Two important outcomes of a study design--power and resolution--are implicitly tied together by the principle of uncertainty. Overemphasis on either one may lead to suboptimal designs. To achieve optimality for a particular study, therefore, practical measures such as cost-effectiveness must be used to strike a balance between power and resolution. In this light, the myriad of factors involved in study design can be checked for their effects on the ultimate outcomes, and the popular existing designs can be sorted into building blocks that may be useful for particular situations. It is hoped that imaginative construction of novel designs using such building blocks will lead to enhanced efficiency in finding genes for complex human traits.

  15. Experimental studies on the Auburn Torsatron: Annual progress report

    International Nuclear Information System (INIS)

    Gandy, R.F.; Swanson, D.G.

    1988-10-01

    This paper discusses research programs in progress on the Auburn Torsatron. Topic areas covered are: ICR heating results; Compact Auburn Torsatron design; Compact Auburn Torsatron construction; and collaborations

  16. Quantitative application study on the control system of contract progress

    International Nuclear Information System (INIS)

    Hu Xiaocong; Kang Rujie; Zhan Li

    2012-01-01

    Quantitative application study on the control system of contract progress, which is based on project management theory and PDCA cycle methods, provides a new way for the contract business management of enterprise, in line with the current situation and the nuclear power enterprise performance management needs. The concept of the system, system development, program design and development of ERP (VBA design) which come from the work experience summary of business managers are convenient and feasible in practical applications. By way of the applications in 2009, 2010, 2011 three-year overhaul contract management and continuous adjustment it has become an important business management tool, which not only effectively guaranteed the contract time and efficiency, but also combines the performance management and contract progress management. This study has provided useful reference for the enterprise management. (authors)

  17. Applying Item Response Theory methods to design a learning progression-based science assessment

    Science.gov (United States)

    Chen, Jing

    Learning progressions are used to describe how students' understanding of a topic progresses over time and to classify the progress of students into steps or levels. This study applies Item Response Theory (IRT) based methods to investigate how to design learning progression-based science assessments. The research questions of this study are: (1) how to use items in different formats to classify students into levels on the learning progression, (2) how to design a test to give good information about students' progress through the learning progression of a particular construct and (3) what characteristics of test items support their use for assessing students' levels. Data used for this study were collected from 1500 elementary and secondary school students during 2009--2010. The written assessment was developed in several formats such as the Constructed Response (CR) items, Ordered Multiple Choice (OMC) and Multiple True or False (MTF) items. The followings are the main findings from this study. The OMC, MTF and CR items might measure different components of the construct. A single construct explained most of the variance in students' performances. However, additional dimensions in terms of item format can explain certain amount of the variance in student performance. So additional dimensions need to be considered when we want to capture the differences in students' performances on different types of items targeting the understanding of the same underlying progression. Items in each item format need to be improved in certain ways to classify students more accurately into the learning progression levels. This study establishes some general steps that can be followed to design other learning progression-based tests as well. For example, first, the boundaries between levels on the IRT scale can be defined by using the means of the item thresholds across a set of good items. Second, items in multiple formats can be selected to achieve the information criterion at all

  18. Designing satisfaction studies

    DEFF Research Database (Denmark)

    Kristensen, Kai; Eskildsen, Jacob Kjær

    2007-01-01

    In the effect sampling method, presentation of researcher, the intro text, the order of questions in the questionnaire along with the number of categories in the rating scale is tested in relation to the design of satisfaction studies. Based on the analyses specific recommendations for designing...... satisfaction studies are given....

  19. JSFR design progress related to development of safety design criteria for Generation IV sodium-cooled fast reactors. (1) Overview

    International Nuclear Information System (INIS)

    Kamide, Hideki; Ando, Masato; Ito, Takaya

    2015-01-01

    JAEA, JAPC and MFBR have been conducting design study for the Japan Sodium-cooled Fast Reactor (JSFR), which is a design concept aiming at future commercial use as sustainable electric power source. As the result of the design study and R and D activity related the innovative technologies incorporated in the design in the Fast Reactor Cycle Technology Development (FaCT) project up to 2010, basic design concept of JSFR was established and its development process to the commercialization including construction and operation of a demonstration version of JSFR was outlined. JSFR is a looptype next generation sodium-cooled fast reactor (SFR), which is aiming at achieving development targets of Generation IV reactors concerning sustainability, safety and reliability, economics and proliferation resistance and physical protection by introducing the innovative technologies such as shortened high-chromium steel piping. The output power is assumed for the design study as 1,500 MWe for the commercial version and 750 MWe for the demonstration version. In FaCT phase I up to 2010, in order to evaluate feasibility to achieve the development targets, the design study has been conducted on the main components and systems. Since 2011, in order to contribute to the development of safety design criteria (SDC) and safety design guideline (SDG), which include the lessons learned from the TEPCO's Fukushima Dai-ichi nuclear power plants accident, in the frame work of Generation IV International Forum (GIF), the design study is focusing on the design measures against severe external events such as earthquake and tsunami. At the same time, the design study is going into detail and paying much attention to the maintenance and repair to make surer its feasibility. This paper summarizes the design concept of the demonstration version of JSFR in which progress of design work was incorporated for the safety issues on SDC and SDG of a SFR. (author)

  20. Accelerator research studies: Progress report, Task B

    International Nuclear Information System (INIS)

    1985-06-01

    The main objectives in Task B of the research program are summarized as follows: (1) studies of the collective acceleration of positive ions from a localized plasma source by an intense relativistic electron beam (IREB), (2) studies of ways in which external control may be achieved over the electron beam front in order to achieve higher ion energies - the Beam Front Accelerator (BFA) concept, and (3) study of electron and ion beam generation in a new kind of compact pulsed accelerator in which energy is stored inductively and switched using a plasma focus opening switch. During the past year, substantial progress was made in each of these areas. Our exploratory research on the collective acceleration of laser-produced ions has confirmed the acceleration of C, Al, and Fe ions to peak energies in excess of 10 MeV/amu. In addition, studies of the relation between collective ion acceleration and electron beam propagation in vacuum have shed new light on the experimental processes that lead to energy transfer from electrons to ions. Meanwhile, extensive progress has been made in our attempts to use analytical theory and numerical simulation to model ion acceleration in these systems. Our resultant improved understanding of the processes that limit the peak ion energy has had a profound impact on our plans for further research in this area. Studies of the Compact Pulsed Accelerator have included both ion and electron beam extraction from the device. Its potential to reduce the volume of pulse power sources by an order of magnitude has already been demonstrated, and plans are currently underway to scale the experiment up to voltages in the 1 MV range

  1. Design progress of the VV sectors and ports towards the ITER construction

    International Nuclear Information System (INIS)

    Utin, Yu.; Ioki, K.; Bachmann, C.

    2007-01-01

    The ITER vacuum vessel (VV) is an all-welded torus-shaped double-wall structure with stiffening ribs between the shells. The VV main function is to provide the high-vacuum and primary confinement boundary. The vessel also supports in-vessel components such as the blanket modules and the divertor cassettes. Along with these components, the VV provides radiation shielding - the neutron heat is removed by water circulating between the shells. To satisfy the manufacture and assembly needs, the VV consists of nine sectors. To provide access inside the vessel for auxiliary plasma heating, diagnostics, vacuum pumping and other needs, the VV is equipped with upper, equatorial and lower ports. The upper and regular equatorial ports are occupied with the port plugs. In addition, there are three ports at the equatorial level dedicated for neutral beam (NB) injection. As the ITER construction phase approaches, the VV design has been improved and developed in more detail with the focus on improved manufacture and reduced cost. Based on achievements of manufacturing studies being performed in cooperation with industry, design improvement of the typical VV sector (1) has been nearly finalized. Design improvement of other sectors is in progress - in particular, of the VV sectors 2 and 3 which interface with the NB ports. For all sectors, the concept for the in-wall shielding has been improved and developed in more detail. The design progress of VV sectors 2-3 has been accompanied by progress in the NB port design (including the beam-facing components to handle the heat flux input of the neutral beams). Design of other port structures has also progressed. Thus, supporting and sealing components between the port plugs and the ports have been further developed with the focus on improved structural performance and maintenance. At the lower level, there are full-size ports, and the pipe feedthroughs and local small penetrations. Design of all port structures at this level has

  2. Environmental Studies Group progress report for 1979

    International Nuclear Information System (INIS)

    Hunt, D.C.; Hurley, J.D.

    1981-01-01

    The 1979 progress report gives descriptions, results, and/or status on programs involving (1) physical transport of radionuclides in blowing dust, (2) radionuclide distributions in the sediment of area water bodies, (3) management of open space lands (including a remote sensing program) at Rocky Flats, (4) the ecology and radioecology of terrestrial open space areas in Plant site lands, (5) biological pathways for radionuclide transport, (6) evaluations of environmental monitoring data on radionuclides in air and water, (7) results of a special soil sampling program on lands adjacent to the Plant site, and (8) two special programs - one concerning evaluations of epidemiological studies of health effects purported to be related to the Plant, and a second that specifies information on accumulations of material in process building filter plenums required for evaluation of potential accidents

  3. Progressive addition spectacle lenses: Design preferences and head movements while reading

    Science.gov (United States)

    Preston, Julie Lynn

    In a subjective preference study, two key progressive addition lens parameters, near zone width and corridor length, were varied in a double-masked, randomized, clinical trial of 49 patients. Each subject received a complete eye examination and a new frame. Each wore 6 pairs of lenses for one week at a time and completed questionnaires relating to vision, adaptation, and satisfaction. The preferred lens was identified from the three near zone width lenses and from the three corridor length lenses. Patient characteristics were analyzed for their effect on design preference. Satisfaction ratings following a brief experience with each design were compared to ratings after one week of wear in order to ascertain the predictability of initial impressions. One lens design appeared twice in the preference trial, providing an assessment of the repeatability of the rating instrument. The lens design with the widest near zone was rated significantly lower than the other near zone width designs for nearly every question relating to vision, adaptation, and satisfaction. This lens was also least preferred of all the designs. Preferences for corridor length were evenly distributed among the three designs. Of patient characteristics, years of progressive addition lens wear and gender significantly affected design preference in this population. Initial impressions were not predictive of satisfaction after a week of wear. The rating instrument was judged to have low repeatability. In the head movement portion of the study, 18 participants from the preference study wore the three near zone width designs while reading three paragraphs of varying print size. From a 20 second recording for each of three different paragraphs with each lens, measures of head rotation and posture were collected. The amplitude of head rotation was significantly affected by print size but not by lens design. The effective zone widths on the lenses scanned by the eyes and the locations of the reading levels

  4. SPFC bus design studies

    Energy Technology Data Exchange (ETDEWEB)

    Potter, L.; Reinkingh, J.

    1999-07-01

    This report presents the results of a study assessing the design options for a solid polymer fuel cell bus. Commercial and operation requirements, environmental and market drivers, and fuel processor modeling are examined. Power train specifications and detailed system design are investigated covering fuel cell system dynamic response, hybrid system size, fuel cell system start-up time, system specifications, and hybrid bus component dimensions and costs. (UK)

  5. Designing a Language Study.

    Science.gov (United States)

    Brown, James Dean

    Some issues in the design of classroom research on second language teaching are discussed, with the intention of helping the researcher avoid conceptual pitfalls that may cripple the study later in the process. This begins with an examination of concerns in sampling, including definition of a population to be studied, alternative sampling…

  6. FY-1979 progress report. Hydrotransport plugging study.

    Energy Technology Data Exchange (ETDEWEB)

    Eyler, L.L.; Lombardo, N.J.

    1980-01-01

    The objective of the Hydrotransport Plugging Study is to investigate phenomena associated with predicting the onset and occurrence of plugging in pipeline transport of coal. This study addresses large particle transport plugging phenomena that may be encountered in run-of-mine operations. The project is being conducted in four tasks: review and analysis of current capabilities and available data, analytical modeling, experimental investigations, and unplugging and static start-up. This report documents work completed in FY-1979 as well as work currently in progress. A review of currently available prediction methods was completed. Applicability of the methods to large particle hydrotransport and the prediction of plugging was evaluated. It was determined that available models were inadequate, either because they are empirical and tuned to a given solid or because they are simplified analytical models incapable of accounting for a wide range of parameters. Complicated regression curve fit models lacking a physical basis cannot be extrapolated with confidence. Several specific conclusions were reached: Recent developments in mechanistic modeling, describing flow conditions at the limit of stationary deposition, provide the best basis for prediction and extrapolation of large particle flow. Certain modeled phenomena require further analytical and experimental investigation to improve confidence levels. Experimental work needs to be performed to support modeling and to provide an adequate data base for comparison purposes. No available model permits treatment of solids mixtures such as coal and rock.

  7. Senior Design in Agricultural Engineering--Progress and Pitfalls.

    Science.gov (United States)

    Holmes, R. G.; Rohrbach, R. P.

    1979-01-01

    Describes a specific senior design course and its objectives. Explains the basic deficiencies and problems for design education in agricultural engineering. Also stresses the effect the project advisor has on students' attitudes toward design and the applications of the course. (SMB)

  8. Progress on the RF Coupling Coil Module Design for the MICE Channel

    International Nuclear Information System (INIS)

    Li, D.; Green, M.A.; Virostek, S.P.; Zisman, M.S.; Lau, W.; White, A.E.; Yang, S.Q.

    2005-01-01

    We describe the progress on the design of the RF coupling coil (RFCC) module for the international Muon Ionization Cooling Experiment (MICE) at Rutherford Appleton Laboratory (RAL) in the UK. The MICE cooling channel design consists of one SFOFO cell that is similar to that of the US Study-II of a neutrino factory. The MICE RFCC module comprises a superconducting solenoid, mounted around four normal conducting 201.25-MHz RF cavities. Each cavity has a pair of thin curved beryllium windows to close the conventional open beam irises, which allows for independent control of the phase in each cavity and for the RF power to be fed separately. The coil package that surrounds the RF cavities is mounted on a vacuum vessel. The RF vacuum is shared between the cavities and the vacuum vessel around the cavities such that there is no differential pressure on the thin beryllium windows. This paper discusses the design progress of the RFCC module and the fabrication progress of a prototype 201.25-MHz cavity

  9. Recent progress in conceptual design of LMFR in China

    International Nuclear Information System (INIS)

    Xu Mi; Ma Dayuan; Chen Yishao

    1996-01-01

    The Chinese Experimental Fast Reactor (CEFR-25) with the thermal power 65MW and electric power 25MW is the first step of the FBR development in China. The aims of this project are as following: As a prototype to accumulate the experiences of design, construction and operation of a fast reactor; as an irradiation facility to develop fuels and materials with high breeding properties and burn up rate; and as a test reactor core, envisaged, to test the fast reactor core with the fuel Ac-contained. After three years preparation for the CEFR design including the development, collection and reviewing of about 50 computer codes and the decision of the main technical selections and of design boundary conditions, from 1990 to July 1992, the conceptual design of the CEFR-25 has been completed. The confirmation and some optimization of the conceptual design have been carried out from October 1992 to the end of 1993. Based on the conceptual design and related optimization, the main features and characteristics of the CEFR-25 has been given in this paper. Spent almost whole year 1994 for the input preparation the CEFR-25 technical design has been started in the early of the year 1995. The input for the technical design mainly includes: design criteria; input parameters; technical selections confirmed in conceptual design; design requirements, etc., which are briefly described in this paper. For the design requirements to the CEFR-25, of the most important is that the reactor should have passive safety properties, in other words, during any credible transient incident, for instance, ULOF-ULOHS and UTOP, etc., by the negative feedback of reactivity the reactor will enter into and be keeping at safety condition without needs of any personal interference. The residual heat will be removed away by natural convection and natural circulation. Finally, the paper gives the general descriptions about the research and development status for this reactor. (author). 5 figs, 4 tabs

  10. Radioactivity studies. Progress report. Volume II

    International Nuclear Information System (INIS)

    Cohen, N.

    1981-09-01

    The metabolism of 243 244 Cm in nine adult female baboons following intravenous injection was studied. Curium-243,244 was administered as a single injection of curium citrate in dosages of 0.053 to 0.220 μCi/kg. The behavior of 243 244 Cm at these low dosages was quantitated by external whole-body and partial-body counting, bioassay of blood, urine and feces samples, liver biopsies, and post-mortem tissues analysis. Curium-243,244 rapidly passed from the blood to other tissues. At 1 and 24 h after injection, the amounts circulating were 10% and 1%, respectively. At 24 h after injection 70% of the 243 244 Cm was located within soft tissues, probably associated with extracellular fluid; the liver alone contained 32% of the injected activity. During the first weeks the content of 243 244 Cm in soft tissues decreased sharply. As time progressed, significant deposition was noted in the liver and the skeleton. Approximately 20% of the injected activity was in the liver at 1 month with a 40 day half-time. The skeleton reached a maximum burden of 57% by 100 days; the half-time observed in bone was 4 to 16 y. During the first 24 h, 10% of the injected activity appeared in the urine decreasing to 0.1%/day at 30 days and 0.01%/day at 200 days. Fecal excretion increased reaching a maximum level at four weeks. The amount of 243 244 Cm excreted in the feces during the initial 4 to 5 months (approx. 20%) and the rate of elimination in the feces after the first month paralleled the retention in the liver indicating an hepatic-biliary-fecal pathway. A model illustrating the interaction of seven internal compartments with respect to the translocation kinetics of 243 244 Cm was derived based upon this data. Solutions of the model were derived for two specific time-related exposures

  11. Design progress of the solar UV-Vis-IR telescope (SUVIT) aboard SOLAR-C

    Science.gov (United States)

    Katsukawa, Y.; Ichimoto, K.; Suematsu, Y.; Hara, H.; Kano, R.; Shimizu, T.; Matsuzaki, K.

    2013-09-01

    We present a design progress of the Solar UV-Vis-IR Telescope (SUVIT) aboard the next Japanese solar mission SOLAR-C. SUVIT has an aperture diameter of ~1.4 m for achieving spectro-polarimetric observations with spatial and temporal resolution exceeding the Hinode Solar Optical Telescope (SOT). We have studied structural and thermal designs of the optical telescope as well as the optical interface between the telescope and the focal plane instruments. The focal plane instruments are installed into two packages, filtergraph and spectrograph packages. The spectropolarimeter is the instrument dedicated to accurate polarimetry in the three spectrum windows at 525 nm, 854 nm, and 1083 nm for observing magnetic fields at both the photospheric and chromospheric layers. We made optical design of the spectrograph accommodating the conventional slit spectrograph and the integral field unit (IFU) for two-dimensional coverage. We are running feasibility study of the IFU using fiber arrays consisting of rectangular cores.

  12. Progress in IFMIF Engineering Validation and Engineering Design Activities

    International Nuclear Information System (INIS)

    Heidinger, R.; Knaster, J.; Matsumoto, H.; Sugimoto, M.; Mosnier, A.; Arbeiter, F.; Baluc, N.; Cara, P.; Chel, S.; Facco, A.; Favuzza, P.; Heinzel, V.; Ibarra, A.; Massaut, V.; Micciche, G.; Nitti, F.S.; Theile, J.

    2013-01-01

    Highlights: ► The IFMIF/EVEDA project has entered into the crucial phase of concluding the Interim IFMIF Engineering Design Report. ► The IFMIF plant configuration has been established with the definition of five IFMIF facilities and of their interfaces. ► Three major prototypes of the IFMIF main systems have been designed and are being manufactured, commissioned and operated. -- Abstract: The International Fusion Materials Irradiation Facility (IFMIF) Engineering Design and Engineering Validation Activities (EVEDA) are being developed in a joint project in the framework of the Broader Approach (BA) Agreement between EU and Japan. This project has now entered into a crucial phase as the engineering design of IFMIF is now being formulated in a series of 3 subsequent phases for delivering an Interim IFMIF Engineering Design Report (IIEDR) by mid of 2013. Content of these phases is explained, including the plant configuration detailing the 5 IFMIF facilities and their systems. Together with the Engineering Design Activities, prototyping sub-projects are pursued in the Engineering Validation Activities which consist of the design, manufacturing and testing of the following prototypical systems: Linear IFMIF Prototype Accelerator (LIPAc), EVEDA Lithium Test Loop (ELTL), and High Flux Test Module (HFTM) with the prototypical helium cooling loop (HELOKA). Highlights are described from recent experiments in the Engineering Validation Activities

  13. Flexible energy-storage devices: design consideration and recent progress.

    Science.gov (United States)

    Wang, Xianfu; Lu, Xihong; Liu, Bin; Chen, Di; Tong, Yexiang; Shen, Guozhen

    2014-07-23

    Flexible energy-storage devices are attracting increasing attention as they show unique promising advantages, such as flexibility, shape diversity, light weight, and so on; these properties enable applications in portable, flexible, and even wearable electronic devices, including soft electronic products, roll-up displays, and wearable devices. Consequently, considerable effort has been made in recent years to fulfill the requirements of future flexible energy-storage devices, and much progress has been witnessed. This review describes the most recent advances in flexible energy-storage devices, including flexible lithium-ion batteries and flexible supercapacitors. The latest successful examples in flexible lithium-ion batteries and their technological innovations and challenges are reviewed first. This is followed by a detailed overview of the recent progress in flexible supercapacitors based on carbon materials and a number of composites and flexible micro-supercapacitors. Some of the latest achievements regarding interesting integrated energy-storage systems are also reviewed. Further research direction is also proposed to surpass existing technological bottle-necks and realize idealized flexible energy-storage devices. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  14. Regulatory design governing progression of population growth phases in bacteria.

    Directory of Open Access Journals (Sweden)

    Agustino Martínez-Antonio

    Full Text Available It has long been noted that batch cultures inoculated with resting bacteria exhibit a progression of growth phases traditionally labeled lag, exponential, pre-stationary and stationary. However, a detailed molecular description of the mechanisms controlling the transitions between these phases is lacking. A core circuit, formed by a subset of regulatory interactions involving five global transcription factors (FIS, HNS, IHF, RpoS and GadX, has been identified by correlating information from the well- established transcriptional regulatory network of Escherichia coli and genome-wide expression data from cultures in these different growth phases. We propose a functional role for this circuit in controlling progression through these phases. Two alternative hypotheses for controlling the transition between the growth phases are first, a continuous graded adjustment to changing environmental conditions, and second, a discontinuous hysteretic switch at critical thresholds between growth phases. We formulate a simple mathematical model of the core circuit, consisting of differential equations based on the power-law formalism, and show by mathematical and computer-assisted analysis that there are critical conditions among the parameters of the model that can lead to hysteretic switch behavior, which--if validated experimentally--would suggest that the transitions between different growth phases might be analogous to cellular differentiation. Based on these provocative results, we propose experiments to test the alternative hypotheses.

  15. Regulatory design governing progression of population growth phases in bacteria.

    Science.gov (United States)

    Martínez-Antonio, Agustino; Lomnitz, Jason G; Sandoval, Santiago; Aldana, Maximino; Savageau, Michael A

    2012-01-01

    It has long been noted that batch cultures inoculated with resting bacteria exhibit a progression of growth phases traditionally labeled lag, exponential, pre-stationary and stationary. However, a detailed molecular description of the mechanisms controlling the transitions between these phases is lacking. A core circuit, formed by a subset of regulatory interactions involving five global transcription factors (FIS, HNS, IHF, RpoS and GadX), has been identified by correlating information from the well- established transcriptional regulatory network of Escherichia coli and genome-wide expression data from cultures in these different growth phases. We propose a functional role for this circuit in controlling progression through these phases. Two alternative hypotheses for controlling the transition between the growth phases are first, a continuous graded adjustment to changing environmental conditions, and second, a discontinuous hysteretic switch at critical thresholds between growth phases. We formulate a simple mathematical model of the core circuit, consisting of differential equations based on the power-law formalism, and show by mathematical and computer-assisted analysis that there are critical conditions among the parameters of the model that can lead to hysteretic switch behavior, which--if validated experimentally--would suggest that the transitions between different growth phases might be analogous to cellular differentiation. Based on these provocative results, we propose experiments to test the alternative hypotheses.

  16. Progress in the planar CPn SOFC system design verification

    Energy Technology Data Exchange (ETDEWEB)

    Elangovan, S.; Hartvigsen, J.; Khandkar, A. [SOFCo, Salt Lake City, UT (United States)

    1996-04-01

    SOFCo is developing a high efficiency, modular and scaleable planar SOFC module termed the CPn design. This design has been verified in a 1.4 kW module test operated directly on pipeline natural gas. The design features multistage oxidation of fuel wherein the fuel is consumed incrementally over several stages. High efficiency is achieved by uniform current density distribution per stage, which lowers the stack resistance. Additional benefits include thermal regulation and compactness. Test results from stack modules operating in pipeline natural gas are presented.

  17. Progress in the study of dusty plasmas

    International Nuclear Information System (INIS)

    Mendis, D A

    2002-01-01

    While the study of dust-plasma interactions is by no means new, early progress in the field was slow and uneven. It received a major boost in the early 1980s with the Voyager spacecraft observations of peculiar features in the Saturnian ring system (e.g. the 'radial spokes') which could not be explained by gravitation alone and led to the development of the gravito-electrodynamic theory of dust dynamics. This theory scored another major success more recently in providing the only possible explanation of collimated high-speed beams of fine dust particles observed to sporadically emanate from Jupiter by the Ulysses and Galileo spacecrafts. These dynamical studies were complimented in the early 1990s by the study of collective processes in dusty plasmas. Not only has this led to the discovery of a whole slew of new wave modes and instabilities with wide ranging consequences for the space environment, it also spurred laboratory studies leading to the observation of several of them, including the very low frequency dust acoustic mode, which can be made strikingly visual by laser light scattering off the dust. The most fascinating new development in dusty plasmas, which occurred about 7 years ago, was the crystallization of dusty plasmas in several laboratories. In these so-called 'plasma crystals', micrometre-sized dust, which are either externally introduced or internally grown in the plasma, acquire large negative charges and form Coulomb lattices as was theoretically anticipated for some time. This entirely new material, whose crystalline structure is so strikingly observed by laser light scattering, could be a valuable tool for studying physical processes in condensed matter, such as melting, annealing and lattice defects. Recognizing the crucial role of gravity on the crystal structure, microgravity experiments have already been performed in aircraft, sounding rockets, the Mir Space Station, and most recently in the International Space Station, leading to

  18. Progress of full MOX core design in ABWR

    International Nuclear Information System (INIS)

    Izutsu, S.; Sasagawa, M.; Aoyama, M.; Maruyama, H.; Suzuki, T.

    2000-01-01

    Full MOX ABWR core design has been made, based on the MOX design concept of 8x8 bundle configuration with a large central water rod, 40 GWd/t maximum bundle exposure, and the compatibility with 9x9 high-burnup UO 2 bundles. Core performance on shutdown margin and thermal margin of the MOX-loaded core is similar to that of UO 2 cores for the range from full UO 2 core to full MOX core. Safety analyses based on its safety parameters and MOX property have shown its conformity to the design criteria in Japan. In order to confirm the applicability of the nuclear design method to full MOX cores, Tank-type Critical Assembly (TCA) experiment data have been analyzed on criticality, power distribution and β eff /l measurements. (author)

  19. Progress on radio frequency auxiliary heating system designs in ITER

    International Nuclear Information System (INIS)

    Makowski, M.; Bosia, G.; Elio, F.

    1996-09-01

    ITER will require over 100 MW of auxiliary power for heating, on- and off-axis current drive, accessing the H-mode, and plasma shut-down. The Electron Cyclotron Range of Frequencies (ECRF) and Ion Cyclotron Range of Frequencies (ICRF) are two forms of Radio Frequency (RF) auxiliary power being developed for these applications. Design concepts for both the ECRF and ICRF systems are presented, key features and critical design issues are discussed, and projected performances outlined

  20. Antarctic Lithosphere Studies: Progress, Problems and Promise

    Science.gov (United States)

    Dalziel, I. W. D.; Wilson, T. J.

    2017-12-01

    In the sixty years since the International Geophysical Year, studies of the Antarctic lithosphere have progressed from basic geological observations and sparse geophysical measurements to continental-scale datasets of radiometric dates, ice thickness, bedrock topography and characteristics, seismic imaging and potential fields. These have been augmented by data from increasingly dense broadband seismic and geodetic networks. The Antarctic lithosphere is known to have been an integral part, indeed a "keystone" of the Pangea ( 250-185Ma) and Gondwanaland ( 540-180 Ma) supercontinents. It is widely believed to have been part of hypothetical earlier supercontinents Rodinia ( 1.0-0.75 Ga) and Columbia (Nuna) ( 2.0-1.5 Ga). Despite the paucity of exposure in East Antarctica, the new potential field datasets have emboldened workers to extrapolate Precambrian geological provinces and structures from neighboring continents into Antarctica. Hence models of the configuration of Columbia and its evolution into Rodinia and Gondwana have been proposed, and rift-flank uplift superimposed on a Proterozoic orogenic root has been hypothesized to explain the Gamburtsev Subglacial Mountains. Mesozoic-Cenozoic rifting has imparted a strong imprint on the West Antarctic lithosphere. Seismic tomographic evidence reveals lateral variation in lithospheric thickness, with the thinnest zones within the West Antarctic rift system and underlying the Amundsen Sea Embayment. Upper mantle low velocity zones are extensive, with a deeper mantle velocity anomaly underlying Marie Byrd Land marking a possible mantle plume. Misfits between crustal motions measured by GPS and GIA model predictions can, in part, be linked with the changes in lithosphere thickness and mantle rheology. Unusually high uplift rates measured by GPS in the Amundsen region can be interpreted as the response of regions with thin lithosphere and weak mantle to late Holocene ice mass loss. Horizontal displacements across the TAM

  1. Accelerator research studies: Annual progress report

    International Nuclear Information System (INIS)

    1988-01-01

    Our major goal in this experiment is to study the physics of a space-charge dominated beam propagating through a long, periodic transport channel consisting in our case of 38 solenoid lenses two of which are being used to match the beam from the gun into the periodic lattice. In addition, a small separate test stand gives us the capability of studying different electron gun designs including measurements of beam perveance and emittance, beam propagation in drift space and through a single solenoid lens. Most of our transport studies in the periodic channel have been conducted with a 5 keV, 200 mA electron beam from a gun with a 1-inch diameter thermionic cathode. The beam physics phenomena of greatest interest are instabilities due to resonant interaction between the beam and the periodic lattice, non-linear effects due to external forces (e.g., spherical lens aberrations) or due to nonuniform charge distributions, beam off-centering and misalignments which also include the effects of image forces. In principle, all of these effects may lead to emittance growth and beam loss. An important question is whether there exists a ''window'' of 100% transmission and minimal emittance growth in such a long periodic channel. 28 refs

  2. Probabilistic Accident Progression Analysis with application to a LMFBR design

    International Nuclear Information System (INIS)

    Jamali, K.M.

    1982-01-01

    A method for probabilistic analysis of accident sequences in nuclear power plant systems referred to as ''Probabilistic Accident Progression Analysis'' (PAPA) is described. Distinctive features of PAPA include: (1) definition and analysis of initiator-dependent accident sequences on the component level; (2) a new fault-tree simplification technique; (3) a new technique for assessment of the effect of uncertainties in the failure probabilities in the probabilistic ranking of accident sequences; (4) techniques for quantification of dependent failures of similar components, including an iterative technique for high-population components. The methodology is applied to the Shutdown Heat Removal System (SHRS) of the Clinch River Breeder Reactor Plant during its short-term (0 -2 . Major contributors to this probability are the initiators loss of main feedwater system, loss of offsite power, and normal shutdown

  3. Coordination: southeast continental shelf studies. Progress report

    Energy Technology Data Exchange (ETDEWEB)

    Menzel, D.W.

    1981-02-01

    The objectives are to identify important physical, chemical and biological processes which affect the transfer of materials on the southeast continental shelf, determine important parameters which govern observed temporal and spatial varibility on the continental shelf, determine the extent and modes of coupling between events at the shelf break and nearshore, and determine physical, chemical and biological exchange rates on the inner shelf. Progress in meeting these research objectives is presented. (ACR)

  4. The benefit of stent placement and blood pressure and lipid-lowering for the prevention of progression of renal dysfunction caused by atherosclerotic ostial stenosis of the renal artery. The STAR-study: rationale and study design.

    NARCIS (Netherlands)

    Bax, L.; Mali, W.P.Th.; Buskens, E.; Koomans, H.A.; Beutler, J.J.; Braam, B.; Beek, F.J.A.; Rabelink, T.J.; Postma, C.T.; Huysmans, F.T.M.; Deinum, J.; Thien, Th.; Schultze Kool, L.J.; Woittiez, A.J.J.; Kouwenberg, J.J.; Meiracker, A.H. van den; Pattynama, P.M.; Ven, P.J. van der; Vroegindeweij, D.; Doorenbos, C.J.; Aarts, J.; Kroon, A.A.; Leeuw, P.W. de; Haan, M.W. de; Engelshoven, J. van; Rutten, M.J.C.M.; Montfrans, G.A. van; Reekers, J.A.; Plouin, P.F.; Batide Alanore, A. La; Azizi, M.; Raynaud, A.; Harden, P.N.; Cowling, M.

    2003-01-01

    BACKGROUND: Atherosclerotic renal artery stenosis (ARAS) is associated with progressive loss of renal function and is one of the most important causes of renal failure in the elderly. Current treatment includes restoration of the renal arterial lumen by endovascular stent placement. However, this

  5. Progress of the ECRH Upper Launcher design for ITER

    International Nuclear Information System (INIS)

    Strauss, D.; Aiello, G.; Bruschi, A.; Chavan, R.; Farina, D.; Figini, L.; Gagliardi, M.; Garcia, V.; Goodman, T.P.; Grossetti, G.; Heemskerk, C.; Henderson, M.A.; Kasparek, W.; Krause, A.; Landis, J.-D.; Meier, A.; Moro, A.; Platania, P.; Plaum, B.; Poli, E.

    2014-01-01

    The design of the ITER ECRH system provides 20 MW millimeter wave power for central plasma heating and MHD stabilization. The system consists of an array of 24 gyrotrons with power supplies coupled to a set of transmission lines guiding the beams to the four upper and the equatorial launcher. The front steering upper launcher design described herein has passed successfully the preliminary design review, and it is presently in the final design stage. The launcher consists of a millimeter wave system and steering mechanism with neutron shielding integrated into an upper port plug with the plasma facing blanket shield module (in-vessel) and a set of ex-vessel waveguides connecting the launcher to the transmission lines. Part of the transmission lines are the ultra-low loss CVD torus diamond windows and a shutter valve, a miter bend section and the feedthroughs integrated in the plug closure plate. These components are connected by corrugated waveguides and form together the first confinement system (FCS). In-vessel, the millimeter-wave system includes a quasi-optical beam propagation system including four mirror sets and a front steering mirror. The millimeter wave system is integrated into a specifically optimized upper port plug providing structural stability to withstand plasma disruption forces and the high heat load from the plasma side with a dedicated blanket shield module. A recent update in the ITER interface definition has resulted in the recession of the upper port plug first wall panels, which is now integrated into the design. Apart from the millimeter wave system the upper port plug houses also a set of shield blocks which provide neutron shielding. An overview of the actual ITER ECRH Upper Launcher is given together with some highlights of the design

  6. The FCC-ee study: Progress and challenges

    CERN Document Server

    Koratzinos, Michael; Bogomyagkov, Anton; Boscolo, Manuela; Cook, Charlie; Doblhammer, Andreas; Härer, Bastian; Tomás, Rogelio; Levichev, Evgeny; Medina Medrano, Luis; Shatilov, Dmitry; Wienands, Ulrich; Zimmermann, Frank

    The FCC (Future Circular Collider) study represents a vision for the next large project in high energy physics, comprising an 80-100 km tunnel that can house a future 100 TeV hadron collider. The study also includes a high luminosity e+e- collider operating in the centre-of-mass energy range of 90-350 GeV as a possible intermediate step, the FCC-ee. The FCC-ee aims at definitive electro-weak precision measurements of the Z, W, H and top particles, and search for rare phenomena. Although FCC-ee is based on known technology, the goal performance in luminosity and energy calibration make it quite challenging. During 2014 the study went through an exploration phase. The study has now entered its second year and the aim is to produce a conceptual design report during the next three to four years. We here report on progress since the last IPAC conference.

  7. Progress and Design Concerns of Nanostructured Solar Energy Harvesting Devices.

    Science.gov (United States)

    Leung, Siu-Fung; Zhang, Qianpeng; Tavakoli, Mohammad Mahdi; He, Jin; Mo, Xiaoliang; Fan, Zhiyong

    2016-05-01

    Integrating devices with nanostructures is considered a promising strategy to improve the performance of solar energy harvesting devices such as photovoltaic (PV) devices and photo-electrochemical (PEC) solar water splitting devices. Extensive efforts have been exerted to improve the power conversion efficiencies (PCE) of such devices by utilizing novel nanostructures to revolutionize device structural designs. The thicknesses of light absorber and material consumption can be substantially reduced because of light trapping with nanostructures. Meanwhile, the utilization of nanostructures can also result in more effective carrier collection by shortening the photogenerated carrier collection path length. Nevertheless, performance optimization of nanostructured solar energy harvesting devices requires a rational design of various aspects of the nanostructures, such as their shape, aspect ratio, periodicity, etc. Without this, the utilization of nanostructures can lead to compromised device performance as the incorporation of these structures can result in defects and additional carrier recombination. The design guidelines of solar energy harvesting devices are summarized, including thin film non-uniformity on nanostructures, surface recombination, parasitic absorption, and the importance of uniform distribution of photo-generated carriers. A systematic view of the design concerns will assist better understanding of device physics and benefit the fabrication of high performance devices in the future. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  8. Molecular design of flotation collectors: A recent progress.

    Science.gov (United States)

    Liu, Guangyi; Yang, Xianglin; Zhong, Hong

    2017-08-01

    The nature of froth flotation is to selectively hydrophobize valuable minerals by collector adsorption so that the hydrophobized mineral particles can attach air bubbles. In recent years, the increasing commercial production of refractory complex ores has been urgent to develop special collectors for enhancing flotation separation efficiency of valuable minerals from these ores. Molecular design methods offer an effective way for understanding the structure-property relationship of flotation collectors and developing new ones. The conditional stability constant (CSC), molecular mechanics (MM), quantitative structure-activity relationship (QSAR), and first-principle theory, especially density functional theory (DFT), have been adopted to build the criteria for designing flotation collectors. Azole-thiones, guanidines, acyl thioureas and thionocarbamates, amide-hydroxamates, and double minerophilic-group surfactants such as Gemini, dithiourea and dithionocarbamate molecules have been recently developed as high-performance collectors. To design hydrophobic groups, the hydrophilic-hydrophobic balance parameters have been extensively used as criteria. The replacement of aryl group with aliphatic group or CC single bond(s) with CC double bond(s), reduction of carbon numbers, introduction of oxygen atom(s) and addition of trisiloxane to the tail terminal have been proved to be useful approaches for adjusting the surface activity of collectors. The role of molecular design of collectors in practical flotation applications was also summarized. Based on the critical review, some comments and prospects for further research on molecular design of flotation collectors were also presented in the paper. Copyright © 2017 Elsevier B.V. All rights reserved.

  9. Seal design alternatives study

    International Nuclear Information System (INIS)

    Van Sambeek, L.L.; Luo, D.D.; Lin, M.S.; Ostrowski, W.; Oyenuga, D.

    1993-06-01

    This report presents the results from a study of various sealing alternatives for the WIPP sealing system. Overall, the sealing system has the purpose of reducing to the extent possible the potential for fluids (either gas or liquid) from entering or leaving the repository. The sealing system is divided into three subsystems: drift and panel seals within the repository horizon, shaft seals in each of the four shafts, and borehole seals. Alternatives to the baseline configuration for the WIPP seal system design included evaluating different geometries and schedules for seal component installations and the use of different materials for seal components. Order-of-magnitude costs for the various alternatives were prepared as part of the study. Firm recommendations are not presented, but the advantages and disadvantages of the alternatives are discussed. Technical information deficiencies are identified and studies are outlined which can provide required information

  10. Progress in design and integration of the ITER Electron Cyclotron H and CD system

    International Nuclear Information System (INIS)

    Darbos, C.; Henderson, M.; Albajar, F.; Bigelow, T.; Bonicelli, T.; Chavan, R.; Denisov, G.G.; Fasel, D.; Heidinger, R.; Hogge, J.P.; Kobayashi, N.; Piosczyk, B.; Rao, S.L.; Rasmussen, D.; Saibene, G.; Sakamoto, K.; Takahashi, K.; Thumm, M.

    2009-01-01

    The Electron Cyclotron system for ITER is an in-kind procurement shared between five parties and the total installed power will be 24 MW, corresponding to a nominal injected power of 20 MW to the plasma, with a possible upgrade up to 48 MW (corresponding to 40 MW injected). Some critical issues have been raised and changes are proposed to simplify these procurements and to facilitate the integration into ITER. The progress in the design and the integration of the EC system into the whole project is presented in this paper, as well as some issues still under studies and some recommendations made by external expert committees.

  11. Willamette oxygen supplementation studies. Annual progress report

    International Nuclear Information System (INIS)

    Ewing, R.D.; Ewing, S.K.; Sheahan, J.E.

    1994-09-01

    Hydropower development and operations in the Columbia River basin have caused the loss of 5 million to 11 million salmonids. An interim goal of the Northwest Power Planning Council is to reestablish these historical numbers by doubling the present runs from 2.5 million adult fish to 5.0 million adult fish. This increase in production will be accomplished through comprehensive management of both wild and hatchery fish, but artificial propagation will play a major role in the augmentation process. The current husbandry techniques in existing hatcheries require improvements that may include changes in rearing densities, addition of oxygen, removal of excess nitrogen, and improvement in raceway design. Emphasis will be placed on the ability to increase the number of fish released from hatcheries that survive to return as adults. Rearing density is one of the most important elements in fish culture. Fish culturists have attempted to rear fish in hatchery ponds at densities that most efficiently use the rearing space available. Such efficiency studies require a knowledge of cost of rearing and the return of adults to the fisheries and to the hatchery

  12. Progress on the reference mirror fusion reactor design

    International Nuclear Information System (INIS)

    Carlson, G.A.; Doggett, J.N.; Moir, R.W.

    1976-01-01

    The design of a reference mirror fusion reactor is underway at Lawrence Livermore Laboratory. The reactor, rated at about 900 MWe, features steady-state operation, an absence of plasma impurity problems, and good accessibility for blanket maintenance. It is concluded that a mirror reactor appears workable, but its dollar/kWe cost will be considerably higher than present-day nuclear costs. The cost would be reduced most markedly by an increase in plasma Q

  13. Formal Learning Sequences and Progression in the Studio: A Framework for Digital Design Education

    Directory of Open Access Journals (Sweden)

    Pontus Wärnestål

    2016-02-01

    Full Text Available This paper examines how to leverage the design studio learning environment throughout long-term Digital Design education in order to support students to progress from tactical, well-defined, device-centric routine design, to confidently design sustainable solutions for strategic, complex, problems for a wide range of devices and platforms in the digital space. We present a framework derived from literature on design, creativity, and theories on learning that: (a implements a theory of formal learning sequences as a user-centered design process in the studio; and (b describes design challenge progressions in the design studio environment modeled in seven dimensions. The framework can be used as a tool for designing, evaluating, and communicating course progressions within – and between series of – design studio courses. This approach is evaluated by implementing a formal learning sequence framework in a series of design studio courses that progress in an undergraduate design-oriented Informatics program. Reflections from students, teachers, and external clients indicate high student motivation and learning goal achievement, high teacher satisfaction and skill development, and high satisfaction among external clients.

  14. Fusion reactor design studies

    International Nuclear Information System (INIS)

    Santarius, J.F.; Kulcinski, G.L.; Emmert, G.A.

    1991-01-01

    This progress report will give a detailed breakdown of the work accomplished for ARIES-III during the contract period, November 1, 1990 to October 31, 1991. The areas of effort discussed are: Neutronics; First-Wall; Shield; Safety; Systems; Startup and Shutdown; Energy Conversion; Ripple Loss; and Fuel Resources

  15. Study progresses on continuous curvilinear capsulorhexis

    Directory of Open Access Journals (Sweden)

    Bo Gao

    2015-10-01

    Full Text Available As the progress of modern techniques for cataract extraction surgery and various needs of intraocular lens(IOLimplantation, continuous curvilinear capsulorhexis(CCCis still in absolute dominance among different ways of incision of anterior capsular lens in clinical practices, due to its advantages such as smoothness of capsulor opening, strong anti-tearing ability, integrity of supporting capsular bag, and strength at maintaining IOL stability. This article describes in general the historical development of CCC and complementary methods adapted to raise success rate when it is used in special cases of cataract extraction surgery. Meanwhile, the article also discusses briefly and envisions the prospects of femotsecond laser applied in CCC technique for cataract extraction.

  16. Fusion reactor design studies

    International Nuclear Information System (INIS)

    Emmert, G.A.; Kulcinski, G.L.; Santarius, J.F.

    1990-01-01

    This report discusses the following topics on the ARIES tokamak: systems; plasma power balance; impurity control and fusion ash removal; fusion product ripple loss; energy conversion; reactor fueling; first wall design; shield design; reactor safety; and fuel cost and resources

  17. Progress in NCSX and QPS design and construction

    International Nuclear Information System (INIS)

    Reiersen, W.; Heitzenroeder, P; Neilson, G.H.; Zarnstorff, M.; Brown, T.; Chrzanowski, J.; Schmidt, J.; Strykowsky, R.; Viola, M.; Nelson, B.; Cole, M.; Fogarty, P.; Goranson, P.; Lyon, J.; Williamson, D.

    2005-01-01

    The National Compact Stellarator Experiment (NCSX) is being constructed at the Princeton Plasma Physics Laboratory (PPPL) in partnership with the Oak Ridge National Laboratory (ORNL). The stellarator core is designed to produce a compact 3-D plasma that combines stellarator and tokamak physics advantages. The engineering challenges of NCSX stem from its complex geometry. From the project's start in April, 2003 to September, 2004, the fabrication specifications for the project's two long-lead components, the modular coil winding forms and the vacuum vessel, were developed. An industrial manufacturing R and D program refined the processes for their fabrication as well as production cost and schedule estimates. The project passed a series of reviews and established its performance baseline with the Department of Energy. In September, 2004, fabrication was approved and contracts for these components were awarded. The suppliers have completed the engineering and tooling preparations and are in production. Meanwhile, the project completed preparations for winding the coils at PPPL by installing a coil manufacturing facility and developing all necessary processes through R and D. The main activities for the next two years will be component manufacture, coil winding, and sub-assembly of the vacuum vessel and coil subsets. Machine sector sub-assembly, machine assembly, and testing will follow, leading to First Plasma in July, 2009. The Quasi-Poloidal Stellarator Experiment (QPS) is an experiment to explore the quasi-poloidal approach to compact stellarators. It will be constructed at ORNL and is a partnership between PPPL, ORNL, and the University of Tennessee. The coil design is very similar to NCSX, but QPS has a smaller aspect ratio and will have an external vacuum vessel. Activities for the next year will focus on R and D, including completion of a prototype modular coil. Detailed design will start in 2007 and the first plasma is expected by 2011. Research supported by

  18. JSFR design progress related to development of safety design criteria for generation IV sodium-cooled fast reactors. (3) Progress of component design

    International Nuclear Information System (INIS)

    Enuma, Yasuhiro; Kawasaki, Nobuchika; Orita, Junichi; Eto, Masao; Miyagawa, Takayuki

    2015-01-01

    In the frame work of generation IV international forum (GIF), safety design criteria (SDC) and safety design guideline (SDG) for the generation IV sodium-cooled fast reactors have been developing in the circumstance of worldwide deployment of SFRs. JAEA, JAPC, MFBR have been investigating design study for JSFR to satisfy SDC in the feasibility study of SDG for Sodium-cooled Fast Reactor (SFR). In addition to the safety measures, maintainability, reparability and manufacturability are taken into account in the JSFR design study. This paper describes the design of main components. Enlargement of the access route for the inspection devices and addition of the access routes were carried out for the reactor structure. The pump-integrated IHX (pump/IHX) was modified for the primary heat exchanger (PHX), which was installed for the decay heat removal in the IHX at the upper plenum, to be removable for improved repair and maintenance. For the steam generator (SG), protective wall tube type design is under investigation as an option with less R and D risks. (author)

  19. Nippon Storm Study design

    Directory of Open Access Journals (Sweden)

    Takashi Kurita

    2012-10-01

    Full Text Available An understanding of the clinical aspects of electrical storm (E-storms in patients with implantable cardiac shock devices (ICSDs: ICDs or cardiac resynchronization therapy with defibrillator [CRT-D] may provide important information for clinical management of patients with ICSDs. The Nippon Storm Study was organized by the Japanese Heart Rhythm Society (JHRS and Japanese Society of Electrocardiology and was designed to prospectively collect a variety of data from patients with ICSDs, with a focus on the incidence of E-storms and clinical conditions for the occurrence of an E-storm. Forty main ICSD centers in Japan are participating in the present study. From 2002, the JHRS began to collect ICSD patient data using website registration (termed Japanese cardiac defibrillator therapy registration, or JCDTR. This investigation aims to collect data on and investigate the general parameters of patients with ICSDs, such as clinical backgrounds of the patients, purposes of implantation, complications during the implantation procedure, and incidence of appropriate and inappropriate therapies from the ICSD. The Nippon Storm Study was planned as a sub-study of the JCDTR with focus on E-storms. We aim to achieve registration of more than 1000 ICSD patients and complete follow-up data collection, with the assumption of a 5–10% incidence of E-storms during the 2-year follow-up.

  20. BWID System Design Study

    International Nuclear Information System (INIS)

    O'Brien, M.C.; Rudin, M.J.; Morrison, J.L.; Richardson, J.G.

    1991-01-01

    The mission of the Buried Waste Integrated Demonstration (BWID) System Design Study is to identify and evaluate technology process options for the cradle-to-grave remediation of Transuranic (TRU)-Contaminated Waste Pits and Trenches buried at the Idaho National Engineering Laboratory (INEL). Emphasis is placed upon evaluating system configuration options and associated functional and operational requirements for retrieving and treating the buried wastes. A Performance-Based Technology Selection Filter was developed to evaluate the identified remediation systems and their enabling technologies based upon system requirements and quantification of technical Comprehensive Environmental Response, Compensation, and Liability (CERCLA) balancing criteria. Remediation systems will also be evaluated with respect to regulatory and institutional acceptance and cost-effectiveness

  1. Progress towards the design of a next linear collider

    International Nuclear Information System (INIS)

    Ruth, R.D.

    1990-06-01

    The purpose of this paper is to review the ongoing research at SLAC toward the design of a next-generation linear collider (NLC). The energy of the collider is taken to be 0.5 TeV in the CM with a view towards upgrading to 1.0 TeV. The luminosity is in the range of 10 33 to 10 34 cm -2 sec -1 . The energy is achieved by acceleration with a gradient of about a factor of five higher than SLC, which yields a linear collider approximately twice as long as SLC. The detailed trade-off length and acceleration will be based on total cost. A very broad optimum occurs when the total linear costs equals the total cost of RF power. The luminosity of the linear collider is obtained basically in two ways. First, the cross-sectional area of the beam is decreased primarily by decreasing the vertical size. This creates a flat beam and is useful for controlling beamstrahlung. Secondly, several bunches (∼10) are accelerated on each RF fill in order to more efficiently extract energy from the RF structure. This effectively increases the repetition rate by an order of magnitude. In the next several sections, we trace the beam through the collider to review the research program at SLAC. 41 refs., 1 fig

  2. The Modern Arabic Book : Design as Agent of Cultural Progress

    NARCIS (Netherlands)

    Abi-Fares, H.

    2017-01-01

    Books in the late nineteenth and early twentieth century played an important role in the dissemination of liberal and nationalist ideologies, thus instigating social change in the Arab world. The focus of this study are printed Arabic books where the ideas of modernity in both form and content were

  3. Wolsong 2, 3, and 4 quarterly progress review report on NSSS design and engineering

    Energy Technology Data Exchange (ETDEWEB)

    Jung, Sung Hoon; Kim, Sun Kee; Park, Tae Keun [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    1995-01-01

    This is the Quarterly Progress Review Report for Wolsong NPP 2, 3 and 4 NSSS Design and Engineering which evaluates the performance of the project and describes the project highlight, manpower loading status, design and engineering and project related meetings by quarterly basis. 29 figs., 16 tabs. (Author).

  4. Studies in Interior Design

    Science.gov (United States)

    Environ Planning Design, 1970

    1970-01-01

    Floor plans and photographs illustrate a description of the Samuel C. Williams Library at Stevens Institute of Technology, Hoboken, N.J. The unusual interior design allows students to take full advantage of the library's resources. (JW)

  5. Studies in genetic discrimination. Final progress report

    Energy Technology Data Exchange (ETDEWEB)

    1994-06-01

    We have screened 1006 respondents in a study of genetic discrimination. Analysis of these responses has produced evidence of the range of institutions engaged in genetic discrimination and demonstrates the impact of this discrimination on the respondents to the study. We have found that both ignorance and policy underlie genetic discrimination and that anti-discrimination laws are being violated.

  6. Advances on ELIC Design Studies

    International Nuclear Information System (INIS)

    Bogacz, S. Alex; Bogacz, S.; Chevtsov, P.; Derbenev, Ya.; Evtushenko, P.; Krafft, G.; Hutton, A.; Li, R.; Merminga, L.; Musson, J.; Yunn, B.; Zhang, Y.; Sayed, H.; Qiang, J.

    2008-01-01

    A conceptual design of a ring-ring electron-ion collider based on CEBAF with a center-of-mass energy up to 90 GeV at luminosity up to 1035 cm-2s-1 has been proposed at JLab to fulfill science requirements. Here, we summarize design progress including collider ring and interaction region optics with chromatic aberration compensation. Electron polarization in the Figure-8 ring, stacking of ion beams in an accumulator-cooler ring, beam-beam simulations and a faster kicker for the circulator electron cooler ring are also discussed

  7. Experimental studies on the Auburn Torsatron: Progress report

    International Nuclear Information System (INIS)

    Gandy, R.F.; Swanson, D.G.

    1987-10-01

    Progress on the Auburn Torsatron is discussed in this report. In particular, experiments are described dealing with methods of surface mapping the magnetic configuration, plasma confinement studies, ion cyclotron heating and modification to the device

  8. Memphis State University Center for Nuclear Studies progress report

    International Nuclear Information System (INIS)

    1976-01-01

    This quarterly report outlines the progress made by the Center for Nuclear Studies at Memphis State University in the development of specialized educational programs for the nuclear industry through the month of February, 1976

  9. Coordination: Southeast Continental Shelf studies. Progress report

    Energy Technology Data Exchange (ETDEWEB)

    Menzel, D.W.

    1981-02-01

    An overview of the Oceanograhic Program of Skidaway Institute of Oceanograhy is presented. Included are the current five year plan for studies of the Southeast Continental Shelf, a summary of research accomplishments, proposed research for 1981-1982, current status of the Savannah Navigational Light Tower, and a list of publications. (ACR)

  10. Rain scavenging studies. Progress report No. 11

    International Nuclear Information System (INIS)

    Dingle, A.N.

    1975-05-01

    The modeling of convective storm scavenging processes is going forward on two distinct fronts. The first of these relates to the microphysical processes, particularly to the study of their response to micro-dynamical components of the convective circulation. It is found that the droplet size spectra generated are responsive to variations of vertical velocity due to turbulence within the cloud and to humidity variations due to entrainment processes. Both sets of variations give responses that differ for different amplitudes and frequencies, i.e., rapid, small-amplitude eddies appear to enhance small-droplet development, whereas slow, large-amplitude oscillations tend to enhance large-droplet development. An allied study of the assumptions used in the microphysical equations is also being made. The second modeling effort is addressed to the problem of three-dimensional representation of convective dynamics. Equations are presented, and some of the problems under attack are discussed

  11. ICPP water inventory study progress report

    International Nuclear Information System (INIS)

    Richards, B.T.

    1993-05-01

    Recent data from the Idaho Chemical Processing Plant (ICPP) indicate that water is entering the sumps located in the bottom of Tank Firm Vaults in quantities that exceed expected levels. In addition, perched water body(s) exist beneath the northern portion of the ICPP. Questions have been raised concerning the origin of water entering the Tank Farm sumps and the recharge sources for the perched water bodies. Therefore, in an effort to determine the source of water, a project has been initiated to identify the source of water for Tank Farm sumps and the perched water bodies. In addition, an accurate water balance for the ICPP will be developed. The purpose of this report is to present the specific results and conclusions for the ICPP water balance portion of the study. In addition, the status of the other activities being conducted as part of study, along with the associated action plans, is provided

  12. ICPP water inventory study progress report

    Energy Technology Data Exchange (ETDEWEB)

    Richards, B.T.

    1993-05-01

    Recent data from the Idaho Chemical Processing Plant (ICPP) indicate that water is entering the sumps located in the bottom of Tank Firm Vaults in quantities that exceed expected levels. In addition, perched water body(s) exist beneath the northern portion of the ICPP. Questions have been raised concerning the origin of water entering the Tank Farm sumps and the recharge sources for the perched water bodies. Therefore, in an effort to determine the source of water, a project has been initiated to identify the source of water for Tank Farm sumps and the perched water bodies. In addition, an accurate water balance for the ICPP will be developed. The purpose of this report is to present the specific results and conclusions for the ICPP water balance portion of the study. In addition, the status of the other activities being conducted as part of study, along with the associated action plans, is provided.

  13. [Progress of heterotrophic studies on symbiotic corals].

    Science.gov (United States)

    Yang, Yang-Chu-Qiao; Hong, Wen Ting; Wang, Shu Hong

    2017-12-01

    Heterotrophy of zooxanthellae symbiotic corals refers to the nutrition directly coming from food absorption, not the nutrition obtained from photosynthesis. Most ex situ propagation of symbiotic corals focused on the effects of irradiation, flow rate and water quality on corals, few of them involved in the demand and supply of coral heterotrophic nutrition. This paper reviewed the significance of heterotrophic nutrient supply to symbiotic corals from the sources of coral heterotrophic nutrition, the factors affecting the supply of coral heterotrophic nutrient, and the methods of how to study the coral heterotrophy. In general, the research of coral heterotrophy is just at the beginning stage, and future studies should focus on the inherent mechanism of coral feeding selection and developing more effective research methods.

  14. Progress report on nuclear spectroscopic studies

    International Nuclear Information System (INIS)

    Bingham, C.R.; Guidry, M.W.; Riedinger, L.L.; Sorensen, S.P.

    1994-01-01

    The Nuclear Physics group at the University of Tennessee, Knoxville (UTK) is involved in several aspects of heavy-ion physics including both nuclear structure and reaction mechanisms. While the main emphasis is on experimental problems, the authors have maintained a strong collaboration with several theorists in order to best pursue the physics of their measurements. During the last year they have had several experiments at the ATLAS at Argonne National Laboratory, the GAMMASPHERE at the LBL 88 Cyclotron, and with the NORDBALL at the Niels Bohr Institute Tandem. Also, they continue to be very active in the WA93/98 collaboration studying ultra-relativistic heavy ion physics utilizing the SPS accelerator at CERN in Geneva, Switzerland and in the PHENIX Collaboration at the RHIC accelerator under construction at Brookhaven National Laboratory. During the last year their experimental work has been in three broad areas: (1) the structure of nuclei at high angular momentum, (2) the structure of nuclei far from stability, and (3) ultra-relativistic heavy-ion physics. The results of studies in these particular areas are described in this document. These studies concentrate on the structure of nuclear matter in extreme conditions of rotational motion, imbalance of neutrons and protons, or very high temperature and density. Another area of research is heavy-ion-induced transfer reactions, which utilize the transfer of nucleons to states with high angular momentum to learn about their structure and to understand the transfer of particles, energy, and angular momentum in collisions between heavy ions

  15. Progress report on nuclear spectroscopic studies

    International Nuclear Information System (INIS)

    Bingham, C.R.; Riedinger, L.L.; Sorensen, S.P.

    1996-01-01

    The experimental program in nuclear physics at the University of Tennessee, Knoxville, is led by Professors Carrol Bingham, Lee Riedinger, and Soren Sorenseni who respectively lead the studies of the exotic decay modes of nuclei far from stability, the program of high-spin research, and our effort in relativistic heavy-ion physics. Over the years, this broad program of research has been successful partially because of the shared University resources applied to this group effort. The proximity of the Oak Ridge National Laboratory has allowed us to build extremely strong programs of joint research, and in addition to play an important leadership role in the Joint Institute for Heavy Ion Research (JIHIR). Our experimental program is also very closely linked with those at other national laboratories: Argonne (collaborations involving the Fragment Mass Analyzer (FMA) and γ-ray arrays), Brookhaven (the RHIC and Phenix projects), and Berkeley (GAMMASPHERE). We have worked closely with a variety of university groups in the last three years, especially those in the UNISOR and now UNIRIB collaborations. And, in all aspects of our program, we have maintained close collaborations with theorists, both to inspire the most exciting experiments to perform and to extract the pertinent physics from the results. The specific areas discussed in this report are: properties of high-spin states; study of low-energy levels of nuclei far from stability; and high energy heavy-ion physics

  16. Studies in development immunogenetics. Annual progress report

    Energy Technology Data Exchange (ETDEWEB)

    Owen, R D

    1975-03-26

    This contract provides the research support for a group concerned with a relatively large range of problems. The integrating thread that runs through it is that of an interest in development and its genetic regulation, mainly in complex organisms and with an emphasis on the immune system as a model for developmental analysis and as a tool for following the development of other systems, especially the brain. It includes studies of biochemical genetics, primarily from a developmental viewpoint and with particular regard to defense mechanisms, and cellular aspects of the immune system. It extends into the area of cancer immunology and cell specificities as related to tumor systems, primarily from an immunogenetic viewpoint and with particular reference to leukemias in the mouse, and to disruptions of genetic control mechanisms in tumor development, especially as approached through the reappearance of fetal antigens associated with tumor development.

  17. Radioactivity studies. Progress report. Volume I

    International Nuclear Information System (INIS)

    Cohen, N.

    1981-09-01

    A model was developed to be used to calculate the accumulation of uranium in the organs of the human body for different kinds of exposure. The proposed model divides the human body into compartments: red cell, short-term bone, long-term bone, kidney, and urine. The transfer rate between compartments is governed by 1st order kinetics. Transfer from plasma to the other compartments is instantaneous. Feedback from compartments to plasma is taken into account. The division of blood into plasma and red cell compartment is important to the calculations of uranium transport during the first few days after exposure. It was noted that uranium in bone has two different half-lives depending on the site of deposition, a short-term and a long-term bone component. An analytical solution to the model was proposed for any time-dependent exposure to uranium. This methodology is unique to this model and represents a significant change in analytical solutions. Specific analytical solutions for common cases of uranium exposure were derived. These include: single injection dose to the blood; exposure to background levels of natural uranium by ingestion; exposure through inhalation during working hours for uranium workers; single inhalation dose; constant inhalation exposure during a finite interval of time; and single ingestion dose. For model verification five baboons were injected intravenously with uranium nitrate and the partition of uranium between plasma and red cells was studied. The half-life in short-term bone was derived and the distribution in soft tissues four days after injection was studied: the kidney was the main organ for uranium deposition. The concentration in human skeleton was equal to 0.02 μg U/g ash. For this concentration in skeleton the gastrointestinal absorption factor was calculated as 23% and the daily excretion as 0.24 μg U/day

  18. HYPER system design study

    Energy Technology Data Exchange (ETDEWEB)

    Park, Won S.; Han, Seok J.; Song, Tae Y. [Korea Atomic Energy Research Institute, Taejon (Korea)

    1999-04-01

    KAERI is developing ADS, named HYPER for the transmutation of nuclear waste. HYPER is designed to produce 1000 MWth with the subcriticality of 0.97. HYPER adopts a hollow cylinder type metal fuel and require 1.0GeV, 16mA proton beams. Pb-Bi is used as coolant and the inlet and outlet temperatures are 340 deg C, 510 deg C, respectively. In addition, Pb-Bi coolant is used as spallation target also. HYPER is expected to incinerate about 380 kg of TRU a year, which is corresponding to the support ratio 5 {approx} 6. 23 refs., 50 figs., 31 tabs. (Author)

  19. Explaining Kansei design studies

    NARCIS (Netherlands)

    Levy, P.D.; Vakamori, S.; Yamanaka, T.

    2008-01-01

    Within the last thirty years, Kansei studies have become an important field of research in Japan. More recently, foreign researchers have become more and more interested in understating the approach, despite the difficulties related to the cultural dimension of Kansei and Kansei studies. The aim of

  20. Study on severe fuel damage and in-vessel melt progression

    International Nuclear Information System (INIS)

    Kim, Hee Dong; Kim, Sang Baik; Lee, Gyu Jung

    1992-06-01

    In-vessel core melt progression describes the progression of the state of a reactor core from core uncovery up to reactor vessel melt through in uncovered accidents or through temperature stabilization in accidents recovered by core reflooding. Melt progression can be thought as two parts; early melt progression and late melt progression. Early phase of core melt progression includes the progression of core material melting and relocation, which mostly consist of metallic materials. On the other hand, the late phase of core melt progression involves ceramic material melt and relocation to the lower plenum and heat-up the reactor vessel lower head. A large number of information are available for the early melt progression through experiments such as SFD, DF, FLHT test and utilized in the severe accident analysis codes. However, understanding of the late phase melt progression phenomenology is based primary on TMI-2 core examinations and not much experimental information is available. Especilally, the great uncertainties exist in vessel failure mode, melt composition, mass, and temperature. Further research is planned to perform to reduce the uncertainties in understanding of core melt down accidents as parts of long term melt progression research program. A study on the core melt progression at KAERI has been being performed through the Severe Accident Research Program with USNRC. KAERI staff had participated in the PBF SFD experiments at INEL and analyses of experiments were performed using SCDAP code. Experiments of core melt program have not been carried out at KAERI yet. It is planned that further research on core melt down accidents will be performed, which is related to design of future generations of nuclear reactors as parts of long-term project for improvement of nuclear reactor safety. (Author)

  1. Optimization of electronic enclosure design for thermal and moisture management using calibrated models of progressive complexity

    DEFF Research Database (Denmark)

    Mohanty, Sankhya; Staliulionis, Zygimantas; Shojaee Nasirabadi, Parizad

    2016-01-01

    the development of rigorous calibrated CFD models as well as simple predictive numerical tools, the current paper tackles the optimization of critical features of a typical two-chamber electronic enclosure. The progressive optimization strategy begins the design parameter selection by initially using simpler...

  2. Overview of Progress on the EU DEMO Reactor Magnet System Design

    NARCIS (Netherlands)

    Zani, L.; Bayer, C.; biancolini, M.E.; Bonifetto, R.; Nijhuis, Arend; Yagotintsev, K.

    2016-01-01

    The DEMO reactor is expected to be the first application of fusion for electricity generation in the near future. To this aim, conceptual design activities are progressing in Europe (EU) under the lead of the EUROfusion Consortium in order to drive on the development of the major tokamak systems. In

  3. Recent progress in ecological studies of soil fauna

    NARCIS (Netherlands)

    Hasegawa, Motohiro; Fujii, Saori; Kaneda, Satoshi; Ikeda, Hiroshi; Hishi, Takuo; Hyodo, Fujio; Kobayashi, Makoto

    2017-01-01

    Progress in ecological studies of soil fauna includes studies of the role and effects of soil fauna on decomposition and soil carbon dynamics in relation to global environmental changes, the introduction of molecular biology approaches to such studies, feeding habit analysis using stable isotopes,

  4. Numerical Investigation of Progressive Collapse Resistance for Seismically Designed RC Buildings

    OpenAIRE

    Marchiş, Adrian G.; Ioani, Adrian M.

    2014-01-01

    In this paper the progressive collapse behavior of a reinforced concrete framed building located in different seismic areas from Romania is investigated. The six-storey structure is designed for low (ag = 0.08 g), moderate (ag = 0.16 g) and high (ag = 0.24 g) seismic zone. Based on the GSA (2003) criteria, a nonlinear static analysis is conducted first in order to estimate the progressive collapse resistance of the models. It was shown that all the structures will collapse when subjected to i...

  5. Technical basis for the ITER-FEAT outline design. Progress in resolving open design issues from the outline design report

    International Nuclear Information System (INIS)

    2000-01-01

    In this publication the technical basis for the ITER-FEAT outline design is presented. It comprises the Plant Design Specifications, the Safety Principles and Environmental Criteria, the Site Requirements and Site Design Assumptions. The outline of the key features of the ITER-FEAT design includes main physical parameters and assessment, design overview and preliminary safety assessment, cost and schedule

  6. Cabling design of booster and storage ring construction progress of TPS

    International Nuclear Information System (INIS)

    Wong, Y.-S.; Liu, K.-B.; Liu, C.-Y.; Wang, B.-S.

    2017-01-01

    The 2012 Taiwan Photon Source (TPS) cable construction project started after 10 months to complete the cable laying and installation of power supply. The circumference of the booster ring (BR) is 496.8 m, whereas that of the storage ring (SR) is 518.4 m. Beam current is set to 500 mA at 3.3 GeV. The paper on grounding systems discusses the design of the ground wire (< 0.2 Ω) with low impedance, power supply of the accelerator and cabling tray. The flow and size of the ground current are carefully evaluated to avoid grounded current from flowing everywhere, which causes interference problems. In the design of the TPS, special shielding will be established to isolate the effects of electromagnetic interference on the magnet and ground current. Booster ring dipoles are connected by a series of 54-magnet bending dipole; the cable size of its stranded wire measures 250 mm"2, with a total length of 5000 m. Booster ring and storage ring quadrupoles have 150 magnets; the cable size of their stranded wire is 250 mm"2, with a total length of 17000 m. Storage ring dipole consists of 48 magnets; the cable size of its stranded wire is 325 mm"2, with a total length of 6000 m. This study discusses the power supply cabling design of the storage ring and booster ring construction progress of TPS. The sections of this paper are divided into discussions of the construction of the control and instrument area, cabling layout of booster ring and storage ring, as well as the installation and commission machine. This study also discusses the use of a high-impedance meter to determine the effect of cabling insulation and TPS power supply machine on energy transfer to ensure the use of safe and correct magnet.

  7. NRC review of passive reactor design certification testing programs: Overview, progress, and regulatory perspective

    Energy Technology Data Exchange (ETDEWEB)

    Levin, A.E.

    1995-09-01

    New reactor designs, employing passive safety systems, are currently under development by reactor vendors for certification under the U.S. Nuclear Regulatory Commission`s (NRC`s) design certification rule. The vendors have established testing programs to support the certification of the passive designs, to meet regulatory requirements for demonstration of passive safety system performance. The NRC has, therefore, developed a process for the review of the vendors` testing programs and for incorporation of the results of those reviews into the safety evaluations for the passive plants. This paper discusses progress in the test program reviews, and also addresses unique regulatory aspects of those reviews.

  8. Academic dismissal policy for medical students : effect on study progress and help-seeking behaviour

    NARCIS (Netherlands)

    Stegers-Jager, Karen M.; Cohen-Schotanus, Janke; Splinter, Ted A. W.; Themmen, Axel P. N.

    2011-01-01

    CONTEXT Medical students often fail to finish medical school within the designated time. An academic dismissal (AD) policy aims to enforce satisfactory progress and to enable early identification and timely support or referral of struggling students. In this study, we assessed whether the

  9. Studies of radiation and chemical toxicity. Progress report

    International Nuclear Information System (INIS)

    1986-01-01

    Annual report for the Studies of Radiation and Chemical Toxicity Program at the University of Rochester is presented. Progress is reported on four projects: Neurobehavorial Toxicity of Organometallic Fuel Additives, Mechanisms of Permanent and Delayed Pathologic Effects of Ionizing Radiation, Solid State Radiation Chemistry of the DNA Backbone, and Pulmonary Biochemistry

  10. Progress of the ITER NBI acceleration grid power supply reference design

    International Nuclear Information System (INIS)

    Toigo, Vanni; Zanotto, Loris; Bigi, Marco; Decamps, Hans; Ferro, Alberto; Gaio, Elena; Gutiérrez, Daniel; Tsuchida, Kazuki; Watanabe, Kazuhiro

    2013-01-01

    Highlights: ► This paper reports the progress in the reference design of the Acceleration Grid Power Supply (AGPS) of the ITER Neutral Beam Injector (NBI) ► A critical revision of the main design choices is presented in light of the definition of some key interface parameters between the two AGPS subsystems. ► The verification of the fulfillment of the requirements in any operational conditions is reported and discussed. -- Abstract: This paper reports the progress in the reference design of the Acceleration Grid Power Supply (AGPS) of the ITER Neutral Beam Injector (NBI). The design of the AGPS is very challenging, as it shall be rated to provide about 55 MW at 1 MV dc in quasi steady-state conditions; moreover, the procurement of the system is shared between the European Domestic Agency (F4E) and the Japanese Domestic Agency (JADA), resulting in additional design complication due to the need of a common definition of the interface parameters. A critical revision of the main design choices is presented also in light of the definition of some key interface parameters between the two AGPS subsystems. Moreover, the verification of the fulfillment of the requirements in any operational conditions taking into account the tolerance of the different parameters is also reported and discussed

  11. Progress on the Design of a Perpendicularly Biased 2nd Harmonic Cavity for the Fermilab Booster

    Energy Technology Data Exchange (ETDEWEB)

    Madrak, R. L. [Fermilab; Dey, J. E. [Fermilab; Duel, K. L. [Fermilab; Kuharik, J. C. [Fermilab; Pellico, W. A. [Fermilab; Reid, J. S. [Fermilab; Romanov, G. [Fermilab; Slabough, M. [Fermilab; Sun, D. [Fermilab; Tan, C. Y. [Fermilab; Terechkine, I. [Fermilab

    2016-10-01

    perpendicularly biased 2nd harmonic cavity is being designed and built for the Fermilab Booster. Its purpose is to flatten the bucket at injection and thus change the longitudinal beam distribution to decrease space charge effects. It can also help at extraction. The cavity frequency range is 76 – 106 MHz. The power amplifier will be built using the Y567B tetrode, which is also used for the fundamental mode cavities in the Fermilab Booster. We discuss recent progress on the cavity, the biasing solenoid design and plans for testing the tuner's garnet material

  12. Chemical engineering in the electronics industry: progress towards the rational design of organic semiconductor heterojunctions

    KAUST Repository

    Clancy, Paulette

    2012-01-01

    We review the current status of heterojunction design for combinations of organic semiconductor materials, given its central role in affecting the device performance for electronic devices and solar cell applications. We provide an emphasis on recent progress towards the rational design of heterojunctions that may lead to higher performance of charge separation and mobility. We also play particular attention to the role played by computational approaches and its potential to help define the best choice of materials for solar cell development in the future. We report the current status of the field with respect to such goals. © 2012 Elsevier Ltd.

  13. Chemical engineering in the electronics industry: progress towards the rational design of organic semiconductor heterojunctions

    KAUST Repository

    Clancy, Paulette

    2012-05-01

    We review the current status of heterojunction design for combinations of organic semiconductor materials, given its central role in affecting the device performance for electronic devices and solar cell applications. We provide an emphasis on recent progress towards the rational design of heterojunctions that may lead to higher performance of charge separation and mobility. We also play particular attention to the role played by computational approaches and its potential to help define the best choice of materials for solar cell development in the future. We report the current status of the field with respect to such goals. © 2012 Elsevier Ltd.

  14. Repository design sensitivity study: Engineering study report

    International Nuclear Information System (INIS)

    1987-01-01

    A preliminary sensitivity study of the salt repository design has been performed to identify critical site and design parameters to help guide future site characterization and design optimization activities. The study considered the SCP-conceptual design at the Deaf Smith County site in Texas with the horizontal waste package emplacement mode as the base case. Relative to this base case, parameter variations were compared. Limited studies were performed which considered the vertical emplacement mode geometry. The report presents the reference data base and design parameters on which the study was based (including the range of parameters that might be expected). Detailed descriptions of the numerical modeling methods and assumptions are included for the thermal, thermomechanical and hydrogeological analyses. The impacts of parameter variations on the sensitivity of the rock mass response are discussed. Recommendations are provided to help guide site characterization activities and advanced conceptual design optimization activities. 47 refs., 119 refs., 22 tabs

  15. 131I albumin of patients carrying progressive systemic sclerosis study

    International Nuclear Information System (INIS)

    Cossermelli, W.; Carvalho, N.; Papaleo Netto, M.

    1974-01-01

    131 I albumin metabolic changes were studied in 14 female patients with progressive systemic sclerosis. A statistical study of the gathered data disclosed increased distribution and turnover half-life and diminished turnover rate of radioactive substance. Since T/2 of turnover and turnover rate are the result produced by the albumin synthesis and degradation, they are probably lowered during active disease causing hypoalbuminemia. The aminoacids also are probably absorbed by other protein like the gammaglobuline synthesis [pt

  16. Study designs may influence results

    DEFF Research Database (Denmark)

    Johansen, Christoffer; Schüz, Joachim; Andreasen, Anne-Marie Serena

    2017-01-01

    appeared to show an inverse association, whereas nested case-control and cohort studies showed no association. For allergies, the inverse association was observed irrespective of study design. We recommend that the questionnaire-based case-control design be placed lower in the hierarchy of studies...... for establishing cause-and-effect for diseases such as glioma. We suggest that a state-of-the-art case-control study should, as a minimum, be accompanied by extensive validation of the exposure assessment methods and the representativeness of the study sample with regard to the exposures of interest. Otherwise...

  17. Visual Design Principles: An Empirical Study of Design Lore

    Science.gov (United States)

    Kimball, Miles A.

    2013-01-01

    Many books, designers, and design educators talk about visual design principles such as balance, contrast, and alignment, but with little consistency. This study uses empirical methods to explore the lore surrounding design principles. The study took the form of two stages: a quantitative literature review to determine what design principles are…

  18. Using CFD as Rocket Injector Design Tool: Recent Progress at Marshall Space Flight Center

    Science.gov (United States)

    Tucker, Kevin; West, Jeff; Williams, Robert; Lin, Jeff; Rocker, Marvin; Canabal, Francisco; Robles, Bryan; Garcia, Robert; Chenoweth, James

    2003-01-01

    objectively summarize what progress has been made at MSFC in enabling CFD as an injector design tool.

  19. Progress in the design of Normal Heat Flux First Wall panels for ITER

    Energy Technology Data Exchange (ETDEWEB)

    Cicero, Tindaro, E-mail: Tindaro.Cicero@f4e.europa.eu [Fusion for Energy, Josep Pla 2, Torres Diagonal Litoral B3, 08019 Barcelona (Spain); Jimenez, Marc; D’Amico, Gabriele; Pou, Jordi Ayneto; Dellopoulos, Georges; Alvaro, Elena; Cardenes, Sabas; Banetta, Stefano; Bellin, Boris; Zacchia, Francesco [Fusion for Energy, Josep Pla 2, Torres Diagonal Litoral B3, 08019 Barcelona (Spain); Calcagno, Barbara; Chappuis, Philippe; Gicquel, Stefan; Mitteau, Raphael; Raffray, Rene [ITER Organization, Route de Vinon-sur-Verdon, CS 90 046, 13067 St., Paul Lez Durance Cedex (France)

    2015-10-15

    Highlights: • Improved detail design of several NHF FW panels for ITER. • Implemented design solutions to improve the manufacturing of NHF FW panels. • Performed FEM simulations for the overall assessment of NHF FW panels. • Performed detailed analyses for integration of diagnostics in the NHF FW panels. - Abstract: A typical NHF FW panel consists of a series of fingers, which represent the elementary plasma facing units and are designed to withstand 15,000 cycles at 2 MW/m{sup 2}. The fingers are mechanically joined and supported by a back structural element or “supporting beam”. The structure of a finger is made of three different materials: stainless steel for the supporting structure, copper chromium zirconium for the heat sink, and beryllium as armour material. Due to their location and to the interfaces with other systems (e.g. Diagnostics, Remote Handling), the NHF FW panels are divided in different main and minor variants. The aim of this paper is to present the design work performed towards the PA signature. CAD detailed models have been created in CATIA for main and minor variants. Examples of local design solutions, as well as design work to achieve the global configuration of specific modules are provided. Finite Element (FE) analyses have been carried out, in order to simulate the operational scenario of ITER and assess the thermo-mechanical behaviour of the most important FW panels against the required design criteria. This design and analyses activity is required to progress towards the finalization of the detailed design of the NHF FW main and minor variants.

  20. Progress in the design of Normal Heat Flux First Wall panels for ITER

    International Nuclear Information System (INIS)

    Cicero, Tindaro; Jimenez, Marc; D’Amico, Gabriele; Pou, Jordi Ayneto; Dellopoulos, Georges; Alvaro, Elena; Cardenes, Sabas; Banetta, Stefano; Bellin, Boris; Zacchia, Francesco; Calcagno, Barbara; Chappuis, Philippe; Gicquel, Stefan; Mitteau, Raphael; Raffray, Rene

    2015-01-01

    Highlights: • Improved detail design of several NHF FW panels for ITER. • Implemented design solutions to improve the manufacturing of NHF FW panels. • Performed FEM simulations for the overall assessment of NHF FW panels. • Performed detailed analyses for integration of diagnostics in the NHF FW panels. - Abstract: A typical NHF FW panel consists of a series of fingers, which represent the elementary plasma facing units and are designed to withstand 15,000 cycles at 2 MW/m"2. The fingers are mechanically joined and supported by a back structural element or “supporting beam”. The structure of a finger is made of three different materials: stainless steel for the supporting structure, copper chromium zirconium for the heat sink, and beryllium as armour material. Due to their location and to the interfaces with other systems (e.g. Diagnostics, Remote Handling), the NHF FW panels are divided in different main and minor variants. The aim of this paper is to present the design work performed towards the PA signature. CAD detailed models have been created in CATIA for main and minor variants. Examples of local design solutions, as well as design work to achieve the global configuration of specific modules are provided. Finite Element (FE) analyses have been carried out, in order to simulate the operational scenario of ITER and assess the thermo-mechanical behaviour of the most important FW panels against the required design criteria. This design and analyses activity is required to progress towards the finalization of the detailed design of the NHF FW main and minor variants.

  1. Recent progress in high-pressure studies on organic conductors

    Directory of Open Access Journals (Sweden)

    Syuma Yasuzuka and Keizo Murata

    2009-01-01

    Full Text Available Recent high-pressure studies of organic conductors and superconductors are reviewed. The discovery of the highest Tc superconductivity among organics under high pressure has triggered the further progress of the high-pressure research. Owing to this finding, various organic conductors with the strong electron correlation were investigated under high pressures. This review includes the pressure techniques using the cubic anvil apparatus, as well as high-pressure studies of the organic conductors up to 10 GPa showing extraordinary temperature and pressure dependent transport phenomena.

  2. The 1989 progress report of GANIL: Operations and machine studies

    International Nuclear Information System (INIS)

    1990-03-01

    The 1989 progress report of the GANIL (French acronym for National Large Accelerator of Heavy Ions) is presented. The studies and the operations performed on the accelerator during the 10th July to the 18th December are summarized. The machine's operating time, the time required in the starting step and the time available for the users are examined. Several technical studies performed are reported. The results obtained after the energy increase operation are satisfactory. The beam intensity was increased of about a factor of 10 [fr

  3. Fundamental studies of separation processes. Technical progress report

    International Nuclear Information System (INIS)

    Rogers, L.B.

    1975-06-01

    Studies using high-precision gas chromatography and supercritical fluid chromatography have produced new types of information on liquid crystals and on behavior of substances in the region of the critical temperature, respectively. In addition, the first successful studies of the effects of pressure on cation exchange have been made using aqueous solutions of alkali metal nitrates. In contrast, progress on separations of isotopic species using gas chromatography has been disappointing. In that area, the chief accomplishment has been a determination of the levels of accuracy and precision with which isotopic abundances can be measured using our quadrupole mass spectrometer. (U.S.)

  4. Using CFD as a Rocket Injector Design Tool: Recent Progress at Marshall Space Flight Center

    Science.gov (United States)

    Tucker, Kevin; West, Jeff; Williams, Robert; Lin, Jeff; Canabal, Francisco; Rocker, marvin; Robles, Bryan; Garcia, Robert; Chenoweth, James

    2005-01-01

    some detail. The objectives of each effort were noted. Issues relative to code validation for injector design were discussed in some detail. The requirement for CFD support during the design of the experiment was noted and discussed in terms of instrumentation placement and experimental rig uncertainty. In conclusion, MSFC has made significant progress in the last two years in advancing CFD toward the goal of application to injector design. A parallel effort focused on program support and technology development via the SCIT Task have enabled the progress.

  5. Design and Co-design of Project-organized Studies

    DEFF Research Database (Denmark)

    Nielsen, Jørgen Lerche; Andreasen, Lars Birch

    2014-01-01

    The chapter contributes to discussions on design processes in relation to education, presenting different notions of design research and demonstrating how professors and students are involved together in designing innovative and constructive study processes that can help foster students' engagement...

  6. Progress in the ITER electron cyclotron heating and current drive system design

    Energy Technology Data Exchange (ETDEWEB)

    Omori, Toshimichi, E-mail: toshimichi.omori@iter.org [ITER Organization, Route de Vinon sur Verdon, CS 90 046, 13067 St Paul Lez Durance Cedex (France); Albajar, Ferran; Bonicelli, Tullio; Carannante, Giuseppe; Cavinato, Mario; Cismondi, Fabio [Fusion for Energy, Josep Pla 2, Barcelona 08019 (Spain); Darbos, Caroline [ITER Organization, Route de Vinon sur Verdon, CS 90 046, 13067 St Paul Lez Durance Cedex (France); Denisov, Grigory [Institute of Applied Physics Russian Academy of Sciences, 46 Ulyanov Street, Nizhny Novgorod 603950 (Russian Federation); Farina, Daniela [Istituto di Fisica del Plasma, Association EURATOM-ENEA-CNR, Milano (Italy); Gagliardi, Mario [Fusion for Energy, Josep Pla 2, Barcelona 08019 (Spain); Gandini, Franco; Gassmann, Thibault [ITER Organization, Route de Vinon sur Verdon, CS 90 046, 13067 St Paul Lez Durance Cedex (France); Goodman, Timothy [CRPP, Association EURATOM-Confédération Suisse, EPFL Ecublens, CH-1015 Lausanne (Switzerland); Hanson, Gregory [US ITER Project Office, ORNL, 055 Commerce Park, PO Box 2008, Oak Ridge, TN 37831 (United States); Henderson, Mark A. [ITER Organization, Route de Vinon sur Verdon, CS 90 046, 13067 St Paul Lez Durance Cedex (France); Kajiwara, Ken [Japan Atomic Energy Agency (JAEA), 801-1 Mukoyama, Naka-shi, Ibaraki 311-0193 (Japan); McElhaney, Karen [US ITER Project Office, ORNL, 055 Commerce Park, PO Box 2008, Oak Ridge, TN 37831 (United States); Nousiainen, Risto [Fusion for Energy, Josep Pla 2, Barcelona 08019 (Spain); Oda, Yasuhisa [Japan Atomic Energy Agency (JAEA), 801-1 Mukoyama, Naka-shi, Ibaraki 311-0193 (Japan); Oustinov, Alexander [Institute of Applied Physics Russian Academy of Sciences, 46 Ulyanov Street, Nizhny Novgorod 603950 (Russian Federation); and others

    2015-10-15

    Highlights: • EC system is designed with an ability to upgrade in power to 28 MW then 40 MW. • The TL is capable of 3 buildings movements; ±15 mm displacements at the worst. • Improved power deposition access injecting 20 MW across nearly the entire plasma. • Ensured nuclear safety by appropriate definition of confinement boundaries. • Proposed I&C architecture for the overall EC plant was successfully reviewed. - Abstract: An electron cyclotron system is one of the four auxiliary plasma heating systems to be installed on the ITER tokamak. The ITER EC system consists of 24 gyrotrons with associated 12 high voltage power supplies, a set of evacuated transmission lines and two types of launchers. The whole system is designed to inject 20 MW of microwave power at 170 GHz into the plasma. The primary functions of the system include plasma start-up, central heating and current drive, and magneto-hydrodynamic instabilities control. The design takes present day technology and extends towards high power CW operation, which represents a large step forward as compared to the present state of the art. The ITER EC system will be a stepping stone to future EC systems for DEMO and beyond. The EC system is faced with significant challenges, which not only includes an advanced microwave system for plasma heating and current drive applications but also has to comply with stringent requirements associated with nuclear safety as ITER became the first fusion device licensed as basic nuclear installations as of 9 November 2012. Since conceptual design of the EC system established in 2007, the EC system has progressed to a preliminary design stage in 2012, and is now moving forward towards a final design. The majority of the subsystems have completed the detailed design and now advancing towards the final design completion.

  7. Progress in the ITER electron cyclotron heating and current drive system design

    International Nuclear Information System (INIS)

    Omori, Toshimichi; Albajar, Ferran; Bonicelli, Tullio; Carannante, Giuseppe; Cavinato, Mario; Cismondi, Fabio; Darbos, Caroline; Denisov, Grigory; Farina, Daniela; Gagliardi, Mario; Gandini, Franco; Gassmann, Thibault; Goodman, Timothy; Hanson, Gregory; Henderson, Mark A.; Kajiwara, Ken; McElhaney, Karen; Nousiainen, Risto; Oda, Yasuhisa; Oustinov, Alexander

    2015-01-01

    Highlights: • EC system is designed with an ability to upgrade in power to 28 MW then 40 MW. • The TL is capable of 3 buildings movements; ±15 mm displacements at the worst. • Improved power deposition access injecting 20 MW across nearly the entire plasma. • Ensured nuclear safety by appropriate definition of confinement boundaries. • Proposed I&C architecture for the overall EC plant was successfully reviewed. - Abstract: An electron cyclotron system is one of the four auxiliary plasma heating systems to be installed on the ITER tokamak. The ITER EC system consists of 24 gyrotrons with associated 12 high voltage power supplies, a set of evacuated transmission lines and two types of launchers. The whole system is designed to inject 20 MW of microwave power at 170 GHz into the plasma. The primary functions of the system include plasma start-up, central heating and current drive, and magneto-hydrodynamic instabilities control. The design takes present day technology and extends towards high power CW operation, which represents a large step forward as compared to the present state of the art. The ITER EC system will be a stepping stone to future EC systems for DEMO and beyond. The EC system is faced with significant challenges, which not only includes an advanced microwave system for plasma heating and current drive applications but also has to comply with stringent requirements associated with nuclear safety as ITER became the first fusion device licensed as basic nuclear installations as of 9 November 2012. Since conceptual design of the EC system established in 2007, the EC system has progressed to a preliminary design stage in 2012, and is now moving forward towards a final design. The majority of the subsystems have completed the detailed design and now advancing towards the final design completion.

  8. Conceptual design main progress of EAST Articulated Maintenance Arm (EAMA) system

    Energy Technology Data Exchange (ETDEWEB)

    Shi, Shanshuang, E-mail: shiss@ipp.ac.cn [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei 230031 (China); Laboratory of Intelligent Machines, Lappeenranta University of Technology (Finland); Song, Yuntao; Cheng, Yong [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei 230031 (China); Villedieu, Eric; Bruno, Vincent [CEA-IRFM, F-13108 Saint-Paul-Lez-Durance (France); Feng, Hansheng [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei 230031 (China); Wu, Huapeng [Laboratory of Intelligent Machines, Lappeenranta University of Technology (Finland); Wang, Peng [State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000 (China); Hao, Zhiwei; Li, Yang; Wang, Kun; Pan, Hongtao [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei 230031 (China)

    2016-03-15

    Highlights: • EAST Articulated Maintenance Arm (EAMA) system is being collaboratively developed by ASIPP and CEA-IRFM. • Conceptual design for a 3-DOF wrist end effector with gripper has been finished. • Kinematic design can reach 90% of the workspace inside EAST tokamak vessel. • A prototype of EAMA arm segment has been built to validate the design. - Abstract: EAST articulated maintenance arm (EAMA) system is being collaboratively developed by ASIPP and CEA-IRFM for the purpose of remote inspection and simple maintenance operations in EAST vacuum vessel during physical experiments without breaking the ultra-high vacuum condition. The EAMA system design is based on a similar articulated inspection arm robot successfully demonstrated in Tore Supra in 2008. In order to better meet EAST configurations and maintenance requirements, optimized mechanisms and dimensions are considered for EAMA robot as upgrades. Besides, the segmented arm is equipped with a 3-DOF wrist end effector and gripper for gripping operation as well as inspection. Some calculations and simulations on statics, kinematics and workspace of EAMA have been presented to validate the feasibility. This paper introduces the overall design of the EAMA robot and presents implementation progress.

  9. Conceptual design main progress of EAST Articulated Maintenance Arm (EAMA) system

    International Nuclear Information System (INIS)

    Shi, Shanshuang; Song, Yuntao; Cheng, Yong; Villedieu, Eric; Bruno, Vincent; Feng, Hansheng; Wu, Huapeng; Wang, Peng; Hao, Zhiwei; Li, Yang; Wang, Kun; Pan, Hongtao

    2016-01-01

    Highlights: • EAST Articulated Maintenance Arm (EAMA) system is being collaboratively developed by ASIPP and CEA-IRFM. • Conceptual design for a 3-DOF wrist end effector with gripper has been finished. • Kinematic design can reach 90% of the workspace inside EAST tokamak vessel. • A prototype of EAMA arm segment has been built to validate the design. - Abstract: EAST articulated maintenance arm (EAMA) system is being collaboratively developed by ASIPP and CEA-IRFM for the purpose of remote inspection and simple maintenance operations in EAST vacuum vessel during physical experiments without breaking the ultra-high vacuum condition. The EAMA system design is based on a similar articulated inspection arm robot successfully demonstrated in Tore Supra in 2008. In order to better meet EAST configurations and maintenance requirements, optimized mechanisms and dimensions are considered for EAMA robot as upgrades. Besides, the segmented arm is equipped with a 3-DOF wrist end effector and gripper for gripping operation as well as inspection. Some calculations and simulations on statics, kinematics and workspace of EAMA have been presented to validate the feasibility. This paper introduces the overall design of the EAMA robot and presents implementation progress.

  10. Optimal filter design with progressive genetic algorithm for local damage detection in rolling bearings

    Science.gov (United States)

    Wodecki, Jacek; Michalak, Anna; Zimroz, Radoslaw

    2018-03-01

    Harsh industrial conditions present in underground mining cause a lot of difficulties for local damage detection in heavy-duty machinery. For vibration signals one of the most intuitive approaches of obtaining signal with expected properties, such as clearly visible informative features, is prefiltration with appropriately prepared filter. Design of such filter is very broad field of research on its own. In this paper authors propose a novel approach to dedicated optimal filter design using progressive genetic algorithm. Presented method is fully data-driven and requires no prior knowledge of the signal. It has been tested against a set of real and simulated data. Effectiveness of operation has been proven for both healthy and damaged case. Termination criterion for evolution process was developed, and diagnostic decision making feature has been proposed for final result determinance.

  11. Building theories from case study research: the progressive case study

    NARCIS (Netherlands)

    Steenhuis, H.J.; de Bruijn, E.J.

    2006-01-01

    Meredith (1998) argues for more case and field research studies in the field of operations management. Based on a literature review, we discuss several existing approaches to case studies and their characteristics. These approaches include; the Grounded Theory approach which proposes no prior

  12. IFMIF High Flux Test Module-Recent progress in design and manufacturing

    Energy Technology Data Exchange (ETDEWEB)

    Leichtle, D. [Association FZK-EURATOM, Forschungszentrum Karlsruhe, Institut fuer Reaktorsicherheit, Hermann-von-Helmholtz-Platz 1, D-76344 Eggenstein-Leopoldshafen (Germany)], E-mail: leichtle@irs.fzk.de; Arbeiter, F.; Dolensky, B.; Fischer, U.; Gordeev, S.; Heinzel, V.; Ihli, T.; Lang, K.-H. [Association FZK-EURATOM, Forschungszentrum Karlsruhe, Institut fuer Reaktorsicherheit, Hermann-von-Helmholtz-Platz 1, D-76344 Eggenstein-Leopoldshafen (Germany); Moeslang, A. [Association FZK-EURATOM, Forschungszentrum Karlsruhe, Institut fuer Materialforschung, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen (Germany); Simakov, S.P.; Slobodchuk, V.; Stratmanns, E. [Association FZK-EURATOM, Forschungszentrum Karlsruhe, Institut fuer Reaktorsicherheit, Hermann-von-Helmholtz-Platz 1, D-76344 Eggenstein-Leopoldshafen (Germany)

    2008-12-15

    The International Fusion Material Irradiation Facility (IFMIF) is an accelerator driven neutron source for irradiation tests of candidate fusion reactor materials. Within the High Flux Test Module (HFTM) a testing volume of 0.5 l filled by qualified small scale specimens will be irradiated at displacement rates of 20-50 dpa/fpy in structural materials. The Forschungszentrum Karlsruhe (FZK) has developed a HFTM design which closely follows the design premise of maximising the space available for irradiation specimens in the IFMIF high flux zone and in addition allows keeping the temperature nearly constant in the rigs containing the specimen. Complementary analyses on nuclear, thermo-hydraulics and mechanical performance of the HFTM were performed to optimize the design. The present paper highlights the main design characteristics as well as recent progress achieved in this area. The contribution also includes (i) recommendations for the use of container, rig and capsule materials, and (ii) a description of the fabrication routes for the entire HFTM including brazing and filling procedures which are currently under development at the Forschungszentrum Karlsruhe.

  13. Design progress of cryogenic hydrogen system for China Spallation Neutron Source

    Energy Technology Data Exchange (ETDEWEB)

    Wang, G. P.; Zhang, Y.; Xiao, J.; He, C. C.; Ding, M. Y.; Wang, Y. Q.; Li, N.; He, K. [Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, P.R. (China)

    2014-01-29

    China Spallation Neutron Source (CSNS) is a large proton accelerator research facility with 100 kW beam power. Construction started in October 2011 and is expected to last 6.5 years. The cryogenic hydrogen circulation is cooled by a helium refrigerator with cooling capacity of 2200 W at 20 K and provides supercritical hydrogen to neutron moderating system. Important progresses of CSNS cryogenic system were concluded as follows. Firstly, process design of cryogenic system has been completed including helium refrigerator, hydrogen loop, gas distribution, and safety interlock. Secondly, an accumulator prototype was designed to mitigate pressure fluctuation caused by dynamic heat load from neutron moderation. Performance test of the accumulator has been carried out at room and liquid nitrogen temperature. Results show the accumulator with welding bellows regulates hydrogen pressure well. Parameters of key equipment have been identified. The contract for the helium refrigerator has been signed. Mechanical design of the hydrogen cold box has been completed, and the hydrogen pump, ortho-para hydrogen convertor, helium-hydrogen heat exchanger, hydrogen heater, and cryogenic valves are in procurement. Finally, Hydrogen safety interlock has been finished as well, including the logic of gas distribution, vacuum, hydrogen leakage and ventilation. Generally, design and construction of CSNS cryogenic system is conducted as expected.

  14. IFMIF High Flux Test Module-Recent progress in design and manufacturing

    International Nuclear Information System (INIS)

    Leichtle, D.; Arbeiter, F.; Dolensky, B.; Fischer, U.; Gordeev, S.; Heinzel, V.; Ihli, T.; Lang, K.-H.; Moeslang, A.; Simakov, S.P.; Slobodchuk, V.; Stratmanns, E.

    2008-01-01

    The International Fusion Material Irradiation Facility (IFMIF) is an accelerator driven neutron source for irradiation tests of candidate fusion reactor materials. Within the High Flux Test Module (HFTM) a testing volume of 0.5 l filled by qualified small scale specimens will be irradiated at displacement rates of 20-50 dpa/fpy in structural materials. The Forschungszentrum Karlsruhe (FZK) has developed a HFTM design which closely follows the design premise of maximising the space available for irradiation specimens in the IFMIF high flux zone and in addition allows keeping the temperature nearly constant in the rigs containing the specimen. Complementary analyses on nuclear, thermo-hydraulics and mechanical performance of the HFTM were performed to optimize the design. The present paper highlights the main design characteristics as well as recent progress achieved in this area. The contribution also includes (i) recommendations for the use of container, rig and capsule materials, and (ii) a description of the fabrication routes for the entire HFTM including brazing and filling procedures which are currently under development at the Forschungszentrum Karlsruhe

  15. Progress on the design of the polarized Medium-energy Electron Ion Collider at JLAB

    Energy Technology Data Exchange (ETDEWEB)

    Lin, F.; Bogacz, A.; Brindza, P.; Camsonne, A.; Daly, E.; Derbenev, Ya. S.; Douglas, D.; Ent, R.; Gaskell, D.; Geng, R.; Grames, J.; Guo, J.; Harwood, L.; Hutton, A.; Jordan, K.; Kimber, A.; Krafft, G.; Li, R.; Michalski, T.; Morozov, V. S.; Nadel-Turonski, P.; /Jefferson Lab /Argonne /DESY /Moscow , Inst. Phys. Tech., Dolgoprydny /Dubna, JINR /Northern Illinois U. /Old Doominion U. /Novosibirsk, GOO Zaryad /SLAC /Texas A-M

    2015-07-14

    The Medium-energy Electron Ion Collider (MEIC) at JLab is designed to provide high luminosity and high polarization needed to reach new frontiers in the exploration of nuclear structure. The luminosity, exceeding 1033 cm-2s-1 in a broad range of the center-of-mass (CM) energy and maximum luminosity above 1034 cm-2s-1, is achieved by high-rate collisions of short small-emittance low-charge bunches made possible by high-energy electron cooling of the ion beam and synchrotron radiation damping of the electron beam. The polarization of light ion species (p, d, 3He) can be easily preserved and manipulated due to the unique figure-8 shape of the collider rings. A fully consistent set of parameters have been developed considering the balance of machine performance, required technical development and cost. This paper reports recent progress on the MEIC accelerator design including electron and ion complexes, integrated interaction region design, figure-8-ring-based electron and ion polarization schemes, RF/SRF systems and ERL-based high-energy electron cooling. Luminosity performance is also presented for the MEIC baseline design.

  16. Progressing state of design and R and D of NBI for ITER

    Energy Technology Data Exchange (ETDEWEB)

    Ohara, Yoshihiro [Japan Atomic Energy Research Inst., Naka, Ibaraki (Japan). Naka Fusion Research Establishment

    1997-02-01

    In the International Thermal Nuclear Fusion Experimental Reactor (ITER), Neutral Beam Injection (NBI) apparatus is thought to be a powerful means of electric current drive for heating and stabilizing of plasma, and of controlling the plasma stably. Then, design and development of 1 MeV class negative ion NBI apparatus with compactness and better consistency with reactor have been conducted. On its engineering design, numbers of ports for NBI apparatus were changed form 3 to 4 on a stage of intermediate design completion on June, 1995, and then incident power per unit port was increased from 12.5 MW to 16.7 MW, which brought severer characteristics required for negative ion source. At present, designs of beam deflector, magnetic shield, neutron shielding, remote maintenance and so forth as well as negative ion source and accelerator have been progressed. On its engineering R and D, for development of negative ion source, both deuterium negative ion current and its density established about 1/3 of the characteristics in ITER actural apparatus at an aimed operational gas pressure. And, for development of negative ion accerelator, over 80% of the negative ion acceleration energy which corresponds to an aim of ITER could be established. (G.K.)

  17. ITER - Progress in design and validating R and D. Note by the Director. ITER meeting, Moscow, 28 June 2000

    International Nuclear Information System (INIS)

    2001-01-01

    This note summarises, for the ITER Council, material presented in detail to TAC, in the report ''Progress in Resolving Open Design Issues from the ODR'', including: further investigation of physics issues raised in the TAC report or in the course of the Parties' domestic assessments; and features of the ITER design which reflect a resolution of choice of options. In addition, the note summarises and illustrates recent progress in the programme of validating technology R and D, as presented in the report to TAC, ''ITER Technology R and D Progress Report''

  18. A Year of Progress: NASA's Space Launch System Approaches Critical Design Review

    Science.gov (United States)

    Askins, Bruce; Robinson, Kimberly

    2015-01-01

    NASA's Space Launch System (SLS) made significant progress on the manufacturing floor and on the test stand in 2014 and positioned itself for a successful Critical Design Review in mid-2015. SLS, the world's only exploration-class heavy lift rocket, has the capability to dramatically increase the mass and volume of human and robotic exploration. Additionally, it will decrease overall mission risk, increase safety, and simplify ground and mission operations - all significant considerations for crewed missions and unique high-value national payloads. Development now is focused on configuration with 70 metric tons (t) of payload to low Earth orbit (LEO), more than double the payload of the retired Space Shuttle program or current operational vehicles. This "Block 1" design will launch NASA's Orion Multi-Purpose Crew Vehicle (MPCV) on an uncrewed flight beyond the Moon and back and the first crewed flight around the Moon. The current design has a direct evolutionary path to a vehicle with a 130t lift capability that offers even more flexibility to reduce planetary trip times, simplify payload design cycles, and provide new capabilities such as planetary sample returns. Every major element of SLS has successfully completed its Critical Design Review and now has hardware in production or testing. In fact, the SLS MPCV-to-Stage-Adapter (MSA) flew successfully on the Exploration Flight Test (EFT) 1 launch of a Delta IV and Orion spacecraft in December 2014. The SLS Program is currently working toward vehicle Critical Design Review in mid-2015. This paper will discuss these and other technical and programmatic successes and challenges over the past year and provide a preview of work ahead before the first flight of this new capability.

  19. Designing and Implementing the Model of Public Assessment of Social and Cultural Progress in Universities

    Directory of Open Access Journals (Sweden)

    Gholamreza Khaje Sarvi

    2013-03-01

    Full Text Available Implementing Investigations, analyzes and performance measurements in special and qualitative social/cultural arena in our country, needs local and special methodologies. Thus the aim of present article is investigating these issues: the concept of culture, classification of cultural organizations in Islamic Republic of Iran, the Pyramidal structure of cultural hierarchy, the process of development and mutual influences of institutions, reviewing related literature of policy making in cultural issues, compatibility of strategies to existing realities in cultural performance structure, double division in measures and analyzing and elaborating suggested measures in elaborating weighting model and assessment method and investigating progress measures by focusing on Islamic-Iranian pattern of progress and investigating the effects of implementing this pattern plus weighting method and using related measures and studying some university cases which are implemented in three phases in universities and high education centers overall the country. This research has shown a linear model by considering weighting coefficients.

  20. Fusion-reactor physics and technology studies. Progress report, December 1, 1982-June 30, 1983

    International Nuclear Information System (INIS)

    Kulcinski, G.L.; Emmert, G.A.; Maynard, C.W.

    1983-01-01

    The work performed during the past fiscal year (1983) was directed almost entirely towards the MARS project. This tandem mirror reactor design study is due to be finished in September of 1983 and a final report will be issued at that time. The present report mainly covers progress made after the interim report and is meant to supplement information in UCRL-53333. The areas covered in this present report are: (1) blanket design improvements; (2) end cell neutronics; (3) RF heating systems; (4) economic optimization of blanket; (5) plasma startup; (6) Li 17 Pb 83 corrosion; (7) double walled steam generator analysis; and (8) tritium system

  1. Improving human reliability through better nuclear power plant system design. Progress report

    International Nuclear Information System (INIS)

    Golay, M.W.

    1995-01-01

    The project on open-quotes Development of a Theory of the Dependence of Human Reliability upon System Designs as a Means of Improving Nuclear Power Plant Performanceclose quotes has been undertaken in order to address the important problem of human error in advanced nuclear power plant designs. Most of the creativity in formulating such concepts has focused upon improving the mechanical reliability of safety related plant systems. However, the lack of a mature theory has retarded similar progress in reducing the likely frequencies of human errors. The main design mechanism used to address this class of concerns has been to reduce or eliminate the human role in plant operations and accident response. The plan of work being pursued in this project is to perform a set of experiments involving human subject who are required to operate, diagnose and respond to changes in computer-simulated systems, relevant to those encountered in nuclear power plants. In the tests the systems are made to differ in complexity in a systematic manner. The computer program used to present the problems to be solved also records the response of the operator as it unfolds. Ultimately this computer is also to be used in compiling the results of the project. The work of this project is focused upon nuclear power plant applications. However, the persuasiveness of human errors in using all sorts of electromechanical machines gives it a much greater potential importance. Because of this we are attempting to pursue our work in a fashion permitting broad generalizations

  2. Design for energy efficiency: Energy efficient industrialized housing research program. Progress report

    Energy Technology Data Exchange (ETDEWEB)

    Kellett, R.; Berg, R.; Paz, A.; Brown, G.Z.

    1991-03-01

    Since 1989, the U.S. Department of Energy has sponsored the Energy Efficient Industrialized Housing research program (EEIH) to improve the energy efficiency of industrialized housing. Two research centers share responsibility for this program: The Center for Housing Innovation at the University of Oregon and the Florida Solar Energy Center, a research institute of the University of Central Florida. Additional funding is provided through the participation of private industry, state governments and utilities. The program is guided by a steering committee comprised of industry and government representatives. This report summarizes Fiscal Year (FY) 1990 activities and progress, and proposed activities for FY 1991 in Task 2.1 Design for Energy Efficiency. This task establishes a vision of energy conservation opportunities in critical regions, market segments, climate zones and manufacturing strategies significant to industrialized housing in the 21st Century. In early FY 1990, four problem statements were developed to define future housing demand scenarios inclusive of issues of energy efficiency, housing design and manufacturing. Literature surveys were completed to assess seven areas of influence for industrialized housing and energy conservation in the future. Fifty-five future trends were identified in computing and design process; manufacturing process; construction materials, components and systems; energy and environment; demographic context; economic context; and planning policy and regulatory context.

  3. Planning for a program design for energy environmental analysis. Progress report

    International Nuclear Information System (INIS)

    Denton, J.C.

    The work reported in this progress report is focused on determining the proper scope of a regional assessment study program suitable for BER/ERDA. Within the tentative scope selected, a tentative set of purposes, goals, and objectives is identified for a preliminary specification of a geographical region. The initial specification of the region includes the states of Pennsylvania, New Jersey, Delaware, Maryland, and Virginia. The tentative scope of considerations for the regional assessment study program encompasses the interacting facets of environment, energy, and economic well-being of the region with the overarching goal of reconciling these facets within the decision framework of the region

  4. Technical meeting on progress in managing, and limiting the consequences of events exceeding the design basis

    International Nuclear Information System (INIS)

    Fabian, H.

    2004-01-01

    The Technical Groups on 'Reactor Safety' and 'Thermodynamics and Fluid Dynamics' of the Kerntechnische Gesellschaft e.V. organized a joint technical meeting on 'Progress in Managing, and Limiting the Consequences of, Events Exceeding the Design Basis' at the FTU Training Center of the Karlsruhe Research Center. The topic chosen, the papers presented, the presenters, and the non-technical part of the program met with lively interest on the part of institutions in the nuclear field. These were the objectives of the technical meeting: - Establishing a forum for communicating relevant topics. - In-depth discussion of the main topic, i.e. the advanced development of reactor safety, research in the field, and its application, in twenty selected papers presented by speakers from different institutions. - Presentation of topical work in a nuclear technology institution, the Karlsruhe Research Center. (orig.) [de

  5. HT-7U superconducting tokamak: Physics design, engineering progress and schedule

    International Nuclear Information System (INIS)

    Wan Yuanxi

    2002-01-01

    The superconducting tokamak research program begun in China in ASIPP since 1994. The program is included in existent superconducting tokamak HT-7 and the next new superconducting tokamak HT-7U which is one of national key research projects in China. With the elongation cross-section, divertor and higher plasma parameter the main objectives of HT-7U are widely investigation both of the physics and technology for steady state advanced tokamak as well as the investigation of power and particle handle under steady-state operation condition. The physics and engineering design have been completed and significant progresses on R and D and fabrication have been achieved. HT-7U will begin assembly at 2003 and possible to get first plasma around 2004. (author)

  6. Designing HIGH-COST medicine: hospital surveys, health planning, and the paradox of progressive reform.

    Science.gov (United States)

    Perkins, Barbara Bridgman

    2010-02-01

    Inspired by social medicine, some progressive US health reforms have paradoxically reinforced a business model of high-cost medical delivery that does not match social needs. In analyzing the financial status of their areas' hospitals, for example, city-wide hospital surveys of the 1910s through 1930s sought to direct capital investments and, in so doing, control competition and markets. The 2 national health planning programs that ran from the mid-1960s to the mid-1980s continued similar strategies of economic organization and management, as did the so-called market reforms that followed. Consequently, these reforms promoted large, extremely specialized, capital-intensive institutions and systems at the expense of less complex (and less costly) primary and chronic care. The current capital crisis may expose the lack of sustainability of such a model and open up new ideas and new ways to build health care designed to meet people's health needs.

  7. Design Evolution Study - Aging Options

    International Nuclear Information System (INIS)

    McDaniel, P.

    2002-01-01

    The purpose of this study is to identify options and issues for aging commercial spent nuclear fuel received for disposal at the Yucca Mountain Mined Geologic Repository. Some early shipments of commercial spent nuclear fuel to the repository may be received with high-heat-output (younger) fuel assemblies that will need to be managed to meet thermal goals for emplacement. The capability to age as much as 40,000 metric tons of heavy metal of commercial spent nuclear he1 would provide more flexibility in the design to manage this younger fuel and to decouple waste receipt and waste emplacement. The following potential aging location options are evaluated: (1) Surface aging at four locations near the North Portal; (2) Subsurface aging in the permanent emplacement drifts; and (3) Subsurface aging in a new subsurface area. The following aging container options are evaluated: (1) Complete Waste Package; (2) Stainless Steel inner liner of the waste package; (3) Dual Purpose Canisters; (4) Multi-Purpose Canisters; and (5) New disposable canister for uncanistered commercial spent nuclear fuel. Each option is compared to a ''Base Case,'' which is the expected normal waste packaging process without aging. A Value Engineering approach is used to score each option against nine technical criteria and rank the options. Open issues with each of the options and suggested future actions are also presented. Costs for aging containers and aging locations are evaluated separately. Capital costs are developed for direct costs and distributable field costs. To the extent practical, unit costs are presented. Indirect costs, operating costs, and total system life cycle costs will be evaluated outside of this study. Three recommendations for aging commercial spent nuclear fuel--subsurface, surface, and combined surface and subsurface are presented for further review in the overall design re-evaluation effort. Options that were evaluated but not recommended are: subsurface aging in a new

  8. [Saarland Growth Study: sampling design].

    Science.gov (United States)

    Danker-Hopfe, H; Zabransky, S

    2000-01-01

    The use of reference data to evaluate the physical development of children and adolescents is part of the daily routine in the paediatric ambulance. The construction of such reference data is based on the collection of extensive reference data. There are different kinds of reference data: cross sectional references, which are based on data collected from a big representative cross-sectional sample of the population, longitudinal references, which are based on follow-up surveys of usually smaller samples of individuals from birth to maturity, and mixed longitudinal references, which are a combination of longitudinal and cross-sectional reference data. The advantages and disadvantages of the different methods of data collection and the resulting reference data are discussed. The Saarland Growth Study was conducted for several reasons: growth processes are subject to secular changes, there are no specific reference data for children and adolescents from this part of the country and the growth charts in use in the paediatric praxis are possibly not appropriate any more. Therefore, the Saarland Growth Study served two purposes a) to create actual regional reference data and b) to create a database for future studies on secular trends in growth processes of children and adolescents from Saarland. The present contribution focusses on general remarks on the sampling design of (cross-sectional) growth surveys and its inferences for the design of the present study.

  9. Establishing Equivalence: Methodological Progress in Group-Matching Design and Analysis

    Science.gov (United States)

    Kover, Sara T.; Atwood, Amy K.

    2013-01-01

    This methodological review draws attention to the challenges faced by intellectual and developmental disabilities researchers in the appropriate design and analysis of group comparison studies. We provide a brief overview of matching methodologies in the field, emphasizing group-matching designs used in behavioral research on cognition and…

  10. Study of atmospheric pollution scavenging. Seventeenth progress report

    Energy Technology Data Exchange (ETDEWEB)

    Semonin, R.G.; Bartlett, J.; Gatz, D.F.; Peden, M.E.; Skowron, L.M.; Stensland, G.J.

    1979-07-01

    The continued study of historical precipitation chemistry, air quality, and emissions data shows that the nitrate concentrations in precipitation have increased over the past 20 years with little change in sulfate concentrations. An analysis of aerosol concentrations at MAP3S precipitation collection sites shows consistently higher elemental concentrations at urban Champaign, Illinois, than sites at Whiteface Mountain, New York, and rural Champaign. Scavenging ratios at Whiteface exceeded those obtained previously at St. Louis, Missouri, possibly due to mid-tropospheric long-range transport and differing synoptic situations. Factor analysis of 6 storms during METROMEX shows that different deposition patterns were found for the soluble and insoluble concentrations of the same element. This suggests different scavenging processes may be active for these fractions. Using METROMEX data, no correlation was found between pollutant source strength and the urban-related precipitation anomaly. Four different Nuclepore air filter setups were used to compare air concentrations of sulfate, nitrate, and ammonium. The sulfate comparison was good, but the large variability for nitrate and ammonium raise serious questions on the credibility of measurements using Nuclepore as the collection medium. The details of a case study of wet deposition from SCORE-78 are presented and shows the pollutant concentrations are more variable than the rainfall. A brief description of the progress on the SCORE-79 project is presented. The progress on acid rainfall studies shows that the high pH values in the Midwest in the mid-1950's were due in part to elevated concentrations of calcium and magnesium. A variety of model calculations are presented to show the effects of adjusting past data to currently observed values. Recent results of continuing research on ionic stability of precipitation samples are given.

  11. AEROSOL PARTICLE COLLECTOR DESIGN STUDY

    Energy Technology Data Exchange (ETDEWEB)

    Lee, S; Richard Dimenna, R

    2007-09-27

    A computational evaluation of a particle collector design was performed to evaluate the behavior of aerosol particles in a fast flowing gas stream. The objective of the work was to improve the collection efficiency of the device while maintaining a minimum specified air throughput, nominal collector size, and minimal power requirements. The impact of a range of parameters was considered subject to constraints on gas flow rate, overall collector dimensions, and power limitations. Potential improvements were identified, some of which have already been implemented. Other more complex changes were identified and are described here for further consideration. In addition, fruitful areas for further study are proposed.

  12. In silico design and biological evaluation of a dual specificity kinase inhibitor targeting cell cycle progression and angiogenesis.

    Directory of Open Access Journals (Sweden)

    Antony M Latham

    Full Text Available Protein kinases play a central role in tumor progression, regulating fundamental processes such as angiogenesis, proliferation and metastasis. Such enzymes are an increasingly important class of drug target with small molecule kinase inhibitors being a major focus in drug development. However, balancing drug specificity and efficacy is problematic with off-target effects and toxicity issues.We have utilized a rational in silico-based approach to demonstrate the design and study of a novel compound that acts as a dual inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2 and cyclin-dependent kinase 1 (CDK1. This compound acts by simultaneously inhibiting pro-angiogenic signal transduction and cell cycle progression in primary endothelial cells. JK-31 displays potent in vitro activity against recombinant VEGFR2 and CDK1/cyclin B proteins comparable to previously characterized inhibitors. Dual inhibition of the vascular endothelial growth factor A (VEGF-A-mediated signaling response and CDK1-mediated mitotic entry elicits anti-angiogenic activity both in an endothelial-fibroblast co-culture model and a murine ex vivo model of angiogenesis.We deduce that JK-31 reduces the growth of both human endothelial cells and human breast cancer cells in vitro. This novel synthetic molecule has broad implications for development of similar multi-kinase inhibitors with anti-angiogenic and anti-cancer properties. In silico design is an attractive and innovative method to aid such drug discovery.

  13. In silico design and biological evaluation of a dual specificity kinase inhibitor targeting cell cycle progression and angiogenesis.

    Science.gov (United States)

    Latham, Antony M; Kankanala, Jayakanth; Fearnley, Gareth W; Gage, Matthew C; Kearney, Mark T; Homer-Vanniasinkam, Shervanthi; Wheatcroft, Stephen B; Fishwick, Colin W G; Ponnambalam, Sreenivasan

    2014-01-01

    Protein kinases play a central role in tumor progression, regulating fundamental processes such as angiogenesis, proliferation and metastasis. Such enzymes are an increasingly important class of drug target with small molecule kinase inhibitors being a major focus in drug development. However, balancing drug specificity and efficacy is problematic with off-target effects and toxicity issues. We have utilized a rational in silico-based approach to demonstrate the design and study of a novel compound that acts as a dual inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2) and cyclin-dependent kinase 1 (CDK1). This compound acts by simultaneously inhibiting pro-angiogenic signal transduction and cell cycle progression in primary endothelial cells. JK-31 displays potent in vitro activity against recombinant VEGFR2 and CDK1/cyclin B proteins comparable to previously characterized inhibitors. Dual inhibition of the vascular endothelial growth factor A (VEGF-A)-mediated signaling response and CDK1-mediated mitotic entry elicits anti-angiogenic activity both in an endothelial-fibroblast co-culture model and a murine ex vivo model of angiogenesis. We deduce that JK-31 reduces the growth of both human endothelial cells and human breast cancer cells in vitro. This novel synthetic molecule has broad implications for development of similar multi-kinase inhibitors with anti-angiogenic and anti-cancer properties. In silico design is an attractive and innovative method to aid such drug discovery.

  14. The DIAN-TU Next Generation Alzheimer’s prevention trial: adaptive design and disease progression model

    Science.gov (United States)

    Bateman, Randall J.; Benzinger, Tammie L.; Berry, Scott; Clifford, David B.; Duggan, Cynthia; Fagan, Anne M.; Fanning, Kathleen; Farlow, Martin R.; Hassenstab, Jason; McDade, Eric M.; Mills, Susan; Paumier, Katrina; Quintana, Melanie; Salloway, Stephen P.; Santacruz, Anna; Schneider, Lon S.; Wang, Guoqiao; Xiong, Chengjie

    2016-01-01

    INTRODUCTION The Dominantly Inherited Alzheimer Network Trials Unit (DIAN-TU) trial is an adaptive platform trial testing multiple drugs to slow or prevent the progression of Alzheimer’s disease in autosomal dominant Alzheimer’s disease (ADAD) families. With completion of enrollment of the first two drug arms, the DIAN-TU now plans to add new drugs to the platform, designated as the Next Generation Prevention Trial (NexGen). METHODS In collaboration with ADAD families, philanthropic organizations, academic leaders, the DIAN-TU Pharma Consortium, the NIH, and regulatory colleagues, the DIAN-TU developed innovative clinical study designs for the DIAN-TU NexGen trial. RESULTS Our expanded trials toolbox consists of a Disease Progression Model for ADAD, primary endpoint DIAN-TU cognitive performance composite, biomarker development, self-administered cognitive assessments, adaptive dose adjustments, and blinded data collection through the last participant completion. CONCLUSION These steps represent elements to improve efficacy of the adaptive platform trial and a continued effort to optimize prevention and treatment trials in ADAD. PMID:27583651

  15. The Progression and Early detection of Subclinical Atherosclerosis (PESA) study

    DEFF Research Database (Denmark)

    Fernández-Ortiz, Antonio; Jiménez-Borreguero, L Jesús; Peñalvo, José L

    2013-01-01

    The presence of subclinical atherosclerosis is a likely predictor of cardiovascular events; however, factors associated with the early stages and progression of atherosclerosis are poorly defined.......The presence of subclinical atherosclerosis is a likely predictor of cardiovascular events; however, factors associated with the early stages and progression of atherosclerosis are poorly defined....

  16. Study of progressive depigmentation of dog′s muzzle

    OpenAIRE

    Shah K

    1991-01-01

    A new animal model is developed using dog′s muzzle to demonstrate progressive depigmen-tation after birth. Dog′s muzzle is heavily pigmented with pigment melanin and looks black in colour. Progressive depigmentation was observed two months after birth in a pup born with a depigmented mucous membrane of the mouth and lips. This resembles the vitiligo of humans.

  17. Theoretical studies in nuclear reactions and nuclear structure. Progress report

    Energy Technology Data Exchange (ETDEWEB)

    1992-05-01

    Research in the Maryland Nuclear Theory Group focusses on problems in four basic areas of current relevance. Hadrons in nuclear matter; the structure of hadrons; relativistic nuclear physics and heavy ion dynamics and related processes. The section on hadrons in nuclear matter groups together research items which are aimed at exploring ways in which the properties of nucleons and the mesons which play a role in the nuclear force are modified in the nuclear medium. A very interesting result has been the finding that QCD sum rules supply a new insight into the decrease of the nucleon`s mass in the nuclear medium. The quark condensate, which characterizes spontaneous chiral symmetry breaking of the late QCD vacuum, decreases in nuclear matter and this is responsible for the decrease of the nucleon`s mass. The section on the structure of hadrons contains progress reports on our research aimed at understanding the structure of the nucleon. Widely different approaches are being studied, e.g., lattice gauge calculations, QCD sum rules, quark-meson models with confinement and other hedgehog models. A major goal of this type of research is to develop appropriate links between nuclear physics and QCD. The section on relativistic nuclear physics represents our continuing interest in developing an appropriate relativistic framework for nuclear dynamics. A Lorentz-invariant description of the nuclear force suggests a similar decrease of the nucleon`s mass in the nuclear medium as has been found from QCD sum rules. Work in progress extends previous successes in elastic scattering to inelastic scattering of protons by nuclei. The section on heavy ion dynamics and related processes reports on research into the e{sup +}e{sup {minus}} problem and heavy ion dynamics.

  18. Transitions Study of predictors of illness progression in young people with mental ill health: study methodology.

    Science.gov (United States)

    Purcell, R; Jorm, A F; Hickie, I B; Yung, A R; Pantelis, C; Amminger, G P; Glozier, N; Killackey, E; Phillips, L; Wood, S J; Mackinnon, A; Scott, E; Kenyon, A; Mundy, L; Nichles, A; Scaffidi, A; Spiliotacopoulos, D; Taylor, L; Tong, J P Y; Wiltink, S; Zmicerevska, N; Hermens, Daniel; Guastella, Adam; McGorry, P D

    2015-02-01

    An estimated 75% of mental disorders begin before the age of 24 and approximately 25% of 13-24-year-olds are affected by mental disorders at any one time. To better understand and ideally prevent the onset of post-pubertal mental disorders, a clinical staging model has been proposed that provides a longitudinal perspective of illness development. This heuristic model takes account of the differential effects of both genetic and environmental risk factors, as well as markers relevant to the stage of illness, course or prognosis. The aim of the Transitions Study is to test empirically the assumptions that underpin the clinical staging model. Additionally, it will permit investigation of a range of psychological, social and genetic markers in terms of their capacity to define current clinical stage or predict transition from less severe or enduring to more severe and persistent stages of mental disorder. This paper describes the study methodology, which involves a longitudinal cohort design implemented within four headspace youth mental health services in Australia. Participants are young people aged 12-25 years who have sought help at headspace and consented to complete a comprehensive assessment of clinical state and psychosocial risk factors. A total of 802 young people (66% female) completed baseline assessments. Annual follow-up assessments have commenced. The results of this study may have implications for the way mental disorders are diagnosed and treated, and progress our understanding of the pathophysiologies of complex mental disorders by identifying genetic or psychosocial markers of illness stage or progression. © 2013 Wiley Publishing Asia Pty Ltd.

  19. State‐of‐the‐art and progress in the optimization‐based simultaneous design and control for chemical processes

    DEFF Research Database (Denmark)

    Yuan, Zhihong; Chen, Bingzhen; Sin, Gürkan

    2012-01-01

    ‐based frameworks that are capable of screening alternative designs, and (2) optimization‐based frameworks that integrate the process design and control system design. The major objective is to give an up‐to‐date review of the state‐of‐the‐art and progress in the challenging area of optimization‐based simultaneous...... design and control. First, motivations and significances of simultaneous design and control are illustrated. Second, a general classification of existing methodologies of optimization‐based simultaneous design and control is outlined. Subsequently, the mathematical formulations and relevant theoretical...

  20. A framework for prospectively defining progression rules for internal pilot studies monitoring recruitment.

    Science.gov (United States)

    Hampson, Lisa V; Williamson, Paula R; Wilby, Martin J; Jaki, Thomas

    2017-01-01

    Just over half of publicly funded trials recruit their target sample size within the planned study duration. When recruitment targets are missed, the funder of a trial is faced with the decision of either committing further resources to the study or risk that a worthwhile treatment effect may be missed by an underpowered final analysis. To avoid this challenging situation, when there is insufficient prior evidence to support predicted recruitment rates, funders now require feasibility assessments to be performed in the early stages of trials. Progression criteria are usually specified and agreed with the funder ahead of time. To date, however, the progression rules used are typically ad hoc. In addition, rules routinely permit adaptations to recruitment strategies but do not stipulate criteria for evaluating their effectiveness. In this paper, we develop a framework for planning and designing internal pilot studies which permit a trial to be stopped early if recruitment is disappointing or to continue to full recruitment if enrolment during the feasibility phase is adequate. This framework enables a progression rule to be pre-specified and agreed upon prior to starting a trial. The novel two-stage designs stipulate that if neither of these situations arises, adaptations to recruitment should be made and subsequently evaluated to establish whether they have been successful. We derive optimal progression rules for internal pilot studies which minimise the expected trial overrun and maintain a high probability of completing the study when the recruitment rate is adequate. The advantages of this procedure are illustrated using a real trial example.

  1. Polymer based flapping-wing robotic insect: Progress in design, fabrication, and characterization

    Science.gov (United States)

    Bontemps, A.; Vanneste, T.; Soyer, C.; Paquet, J. B.; Grondel, S.; Cattan, E.

    2014-03-01

    In the last decade, many researchers pursued the development of tiny flying robots inspired by natural flyers destined for the exploration of confined spaces, for example. Within this context, our main objective is to devise a flying robot bioinspired from insect in terms of size and wing kinematics using MEMS technologies. For this purpose, an original design has been developed around resonant thorax and wings by the way of an indirect actuation and a concise transmission whereas the all-polymer prototypes are obtained using a micromachining SU-8 photoresist process. This paper reports our recent progress on the design of a flapping-wing robotic insect as well as on the characterization of its performance. Prototypes with a wingspan of 3 cm and a mass of 22 mg are achieved. Due to the introduction of an innovative compliant link, large and symmetrical bending angles of 70° are obtained at a flapping frequency of 30 Hz along with passive wing torsion while minimizing its energy expenditure. Furthermore, it leads to a mean lift force representing up to 75 % of the prototype weight as measured by an in-house force sensor. Different improvements are currently underway to increase the power-to-weight ratio of the prototype and to obtain an airborne prototype.

  2. Recent progress of neuroimaging studies on sleeping brain

    International Nuclear Information System (INIS)

    Sasaki, Yuka

    2012-01-01

    Although sleep is a familiar phenomenon, its functions are yet to be elucidated. Understanding these functions of sleep is an important focus area in neuroscience. Electroencephalography (EEG) has been the predominantly used method in human sleep research but does not provide detailed spatial information about brain activation during sleep. To supplement the spatial information provided by this method, researchers have started using a combination of EEG and various advanced neuroimaging techniques that have been recently developed, including positron emission tomography (PET) and magnetic resonance imaging (MRI). In this paper, we will review the recent progress in sleep studies, especially studies that have used such advanced neuroimaging techniques. First, we will briefly introduce several neuroimaging techniques available for use in sleep studies. Next, we will review the spatiotemporal brain activation patterns during non-rapid eye movement (NREM) and rapid eye movement (REM) sleep, the dynamics of functional connectivity during sleep, and the consolidation of learning and memory during sleep; studies on the neural correlates of dreams, which have not yet been identified, will also be discussed. Lastly, possible directions for future research in this area will be discussed. (author)

  3. [Recent progress of neuroimaging studies on sleeping brain].

    Science.gov (United States)

    Sasaki, Yuka

    2012-06-01

    Although sleep is a familiar phenomenon, its functions are yet to be elucidated. Understanding these functions of sleep is an important focus area in neuroscience. Electroencephalography (EEG) has been the predominantly used method in human sleep research but does not provide detailed spatial information about brain activation during sleep. To supplement the spatial information provided by this method, researchers have started using a combination of EEG and various advanced neuroimaging techniques that have been recently developed, including positron emission tomography (PET) and magnetic resonance imaging (MRI). In this paper, we will review the recent progress in sleep studies, especially studies that have used such advanced neuroimaging techniques. First, we will briefly introduce several neuroimaging techniques available for use in sleep studies. Next, we will review the spatiotemporal brain activation patterns during non-rapid eye movement (NREM) and rapid eye movement (REM) sleep, the dynamics of functional connectivity during sleep, and the consolidation of learning and memory during sleep; studies on the neural correlates of dreams, which have not yet been identified, will also be discussed. Lastly, possible directions for future research in this area will be discussed.

  4. HTS Insert Magnet Design Study

    CERN Document Server

    Devaux, M; Fleiter, J; Fazilleau, P; Lécrevisse, T; Pes, C; Rey, J-M; Rifflet, J-M; Sorbi, M; Stenvall, A; Tixador, P; Volpini, G

    2011-01-01

    Future accelerator magnets will need to reach higher field in the range of 20 T. This field level is very difficult to reach using only Low Temperature Superconductor materials whereas High Temperature Superconductors (HTS) provide interesting opportunities. High current densities and stress levels are needed to design such magnets. YBCO superconductor indeed carries large current densities under high magnetic field and provides good mechanical properties especially when produced using the IBAD approach. The HFM EUCARD program studies the design and the realization of an HTS insert of 6 T inside a Nb$_{3}$Sn dipole of 13T at 4.2 K. In the2HTS insert, engineering current densities higher than 250 MA/m under 19 T are required to fulfill the specifications. The stress level is also very severe. YBCO IBAD tapes theoretically meet these challenges from presented measurements. The insert protection is also a critical because HTS materials show low quench propagation velocities and the coupling with the Nb$_{3}$Sn m...

  5. Fathers' experience of childbirth when non-progressive labour occurs and augmentation is established. A qualitative study

    DEFF Research Database (Denmark)

    Hasman, Kirsten; Kjaergaard, Hanne; Esbensen, Bente Appel

    2014-01-01

    as uncontrollable processes and (3) Relief about the decision of augmentation. The fathers had a rational approach and felt powerless when the process of labour was uncontrollable. They felt they were not able to help their partners in pain when non-progressive labour occurred. They experienced relief when......OBJECTIVE: Augmentation with oxytocin during labour has increased in Western obstetrics over the last few decades. The aim of this study was to describe how fathers experienced childbirth when non-progressive labour occurred and augmentation was established. METHOD: A qualitative descriptive design...... after experiencing the non-progressive labour, need directions from the midwives to carry out appropriate and usefull tasks....

  6. Borehole cement and rock properties studies: progress report, October 1, 1976--September 30, 1977

    International Nuclear Information System (INIS)

    Roy, D.M.

    1977-01-01

    Research progress is reported in sections on properties of cements, permeability studies, cement-rock interactions, cement long range stability, waste-rock interactions, and properties of shale. Results suggest that present canister emplacement design is inadequate. Present data suggest that canisters should be placed to a depth at least as great as the width of the chamber opening. This means, with current geometry, burial of the top of the canister to 18 ft. depth. For certain materials, and with further study of the question, design requirements may prove even more stringent. Other aspects of the problem remain to be adequately considered; these aspects may be influential in affecting burial design criteria. These factors include general thermoelastic effects, fluid pressures, and effects of pre-existing discontinuities, as well as site-specific issues

  7. HTGR process heat program design and analysis. Semiannual progress report, October 1, 1979-March 28, 1980

    International Nuclear Information System (INIS)

    1980-10-01

    This report summarizes the results of concept design studies implemented at General Atomic Company (GA) during the first half of FY-80. The studies relate to a plant design for an 842-MW(t) High-Temperature Gas-Cooled Reactor utilizing an intermediate helium heat transfer loop to provide high temperature thermal energy for the production of hydrogen or synthesis gas (H 2 + CO) by steam-reforming a light hydrocarbon. Basic carbon sources may be coal, residual oil, or oil shale. Work tasks conducted during this period included the 842-MW(t) plant concept design and cost estimate for an 850 0 C reactor outlet temperature. An assessment of the main-loop cooling shutdown system is reported. Major component cost models were prepared and programmed into the Process Heat Reactor Evaluation and Design (PHRED) code

  8. Genome-wide association studies in asthma: progress and pitfalls

    Directory of Open Access Journals (Sweden)

    March ME

    2015-01-01

    Full Text Available Michael E March,1 Patrick MA Sleiman,1,2 Hakon Hakonarson1,2 1Center for Applied Genomics, Children's Hospital of Philadelphia Research Institute, 2Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA Abstract: Genetic studies of asthma have revealed that there is considerable heritability to the phenotype. An extensive history of candidate-gene studies has identified a long list of genes associated with immune function that are potentially involved in asthma pathogenesis. However, many of the results of candidate-gene studies have failed to be replicated, leaving in question the true impact of the implicated biological pathways on asthma. With the advent of genome-wide association studies, geneticists are able to examine the association of hundreds of thousands of genetic markers with a phenotype, allowing the hypothesis-free identification of variants associated with disease. Many such studies examining asthma or related phenotypes have been published, and several themes have begun to emerge regarding the biological pathways underpinning asthma. The results of many genome-wide association studies have currently not been replicated, and the large sample sizes required for this experimental strategy invoke difficulties with sample stratification and phenotypic heterogeneity. Recently, large collaborative groups of researchers have formed consortia focused on asthma, with the goals of sharing material and data and standardizing diagnosis and experimental methods. Additionally, research has begun to focus on genetic variants that affect the response to asthma medications and on the biology that generates the heterogeneity in the asthma phenotype. As this work progresses, it will move asthma patients closer to more specific, personalized medicine. Keywords: asthma, genetics, GWAS, pharmacogenetics, biomarkers

  9. IFMIF high flux test module - recent progress in design and manufacturing

    International Nuclear Information System (INIS)

    Leichtle, D.; Arbeiter, F.; Dolensky, B.

    2007-01-01

    The International Fusion Material Irradiation Facility (IFMIF) is an accelerator driven neutron source for irradiation tests of candidate fusion reactor materials. Two 40 MeV deuterium beams with 125 mA each strike a liquid lithium jet target, producing a high intensity neutron flux up to 55 MeV, which penetrates the adjacent test modules. Within the High Flux Test Module (HFTM) a testing volume of 0.5 litres filled by qualified small scale specimens will be irradiated at displacement rates of 20-50 dpa/fpy in structural materials. The HFTM will also provide helium and hydrogen production to dpa ratios that reflect within the uncertainties the values expected in a DEMO fusion reactor The Forschungszentrum Karlsruhe (FZK) has developed a HFTM design which closely follows the design premise of maximising the space available for irradiation specimens in the IFMIF high flux zone and in addition allows keeping the temperature nearly constant in the rigs containing the specimen. Within the entire specimen stack the temperature deviation will be below about 15 K. The main design principles applied are (i) filling the gaps between the specimens with liquid metal, (ii) winding three separately controlled heater sections on the inner capsules and (iii) dividing the test rigs in a hot inner and a cold outer zone, which a separated by a gap filled with stagnant helium that serves as a thermal insulator. Channels between the outer covers (the cold parts) are cooled by helium gas at moderate pressure (3 bars at inlet) and temperature (50 C). 12 identical rigs holding the specimen capsules which are heated by segmented helically wound electrical heaters ensure a flexible loading scheme during IFMIF operation. Complementary analyses on nuclear, thermo-hydraulics and mechanical performance of the HFTM were performed to optimize the design. The present paper highlights the main design characteristics as well as recent progress achieved in this area. This includes the stiffening of

  10. Progress of Design Improvements for APR1400 Computerized Procedure System from HFE V and V results and Design Experience

    International Nuclear Information System (INIS)

    Lee, Sungjin; Seong, Nokyu

    2015-01-01

    This study shows major already improved design features from the above three processes and a design proposal for to-be-improving items. APR1400 CPS has been verified and validated by the HFE process, internal design review and site acceptance tests. APR1400 Computerized Procedure System (CPS) has been applied to Shin-Kori Nuclear Power Plant (SKN) 3 and 4 units, Shin-Hanul Nuclear Power Plant (SHN) 1 and 2 units and Baraka Nuclear Power Plant (BNPP) 1, 2, 3 and 4 units. Since APR1400 CPS is a first-of-a-kind (FOAK) human machine interface (HMI) for executing a computerized procedure in the nuclear power plant's main control room in South Korea, it has been continuously improved through a) the human factor engineering (HFE) verification and validation (V and V), b) the internal design review and c) prototype tests. Human engineering discrepancies (HEDs) can be identified by the HFE V and V activity. Some HEDs of APR1400 CPS for SKN 3 and 4 and SHN 1 and 2 have been adopted as a role of design improvement in the CPS system while others were regarded as an operator training requirement or part of task contents. Various requests for improving the CPS have been collected from those results. A HMI system should be improved continuously for removing potential defects. Some of introduced design features in this paper has been adopted for APR1400 nuclear power plants. Some of them are under the review in the CPS design team of KHNP

  11. MRI study in spondyloepiphyseal dysplasia tarda with progressive arthropathy

    International Nuclear Information System (INIS)

    Tan Lihua; Liao Eryuan; Xiao Enhua; Ma Cong; Du Wanping; Li Jian

    2005-01-01

    Objective: To study the MRI features and the cartilaginous pathology of the spondyloepiphyseal dysplasia tarda with progressive arthropathy (SEDT-PA). Methods: MRI of spine, bilateral hips, and knees was taken in 2 cases with clinically and radiographically proven SEDT-PA, who were sister and brother and whose parents were healthy and not inbreeding. The sister's femoral heads were resected bilaterally and the tissues were used for pathological study. Results: MRI showed that the kyphosis and lateroflexion of the spine, and the degenerative signs of the intervertebral discs became more evident along with the growth of the patients. The anterior annular secondary ossification centers of cartilaginous epiphyses of some vertebral bodies didn't appear. So the affected vertebral bodies were like 'inverted vase' or the end p late like 'steps'. Bilateral acetabular cartilage and medial epicondylian cartilaginous epiphyses of the femurs in the young brother showed regional high signal intensity on coronal fat-saturated proton density weighted MR images and degenerative signs on the elder sister. The regional hyperplasia and hypogenesis of the femoral head cartilage could be seen by microscope. Conclusion: There are characteristic features on MRI in SEDT-PA and this is due to the regional hyperplasia and hypogenesis of the cartilage pathologically. (authors)

  12. Progression to impaired glucose regulation and diabetes in the population-based Inter99 study

    DEFF Research Database (Denmark)

    Engberg, Susanne; Vistisen, Dorte; Lau, Cathrine

    2009-01-01

    Objective: To estimate the progression rates to impaired glucose regulation (impaired fasting glucose or impaired glucose tolerance) and diabetes in the Danish population-based Inter99 study and in a high-risk subpopulation, separately. Research Design and Methods: From a population-based primary...... glucose regulation using the current World Health Organization classification criteria were calculated for the first time in a large European population-based study. The progression rates to diabetes show the same pattern as seen in the few similar European studies....... prevention study, the Inter99 study, 4,615 individuals without diabetes at baseline and with relevant follow-up data were divided into a low- and a high-risk group based on a risk estimate of ischemic heart disease or the presence of risk factors (smoking, hypertension, hypercholesterolemia, obesity...... estimated directly from baseline to 5-year follow-up for all the participants, and from baseline through 1- and 3-, to 5-year follow-up for the high-risk individuals, separately. Results: In the combined low- and high-risk group, 2.1 per 100 person-years progressed from normal glucose tolerance to impaired...

  13. Progressive statistics for studies in sports medicine and exercise science.

    Science.gov (United States)

    Hopkins, William G; Marshall, Stephen W; Batterham, Alan M; Hanin, Juri

    2009-01-01

    Statistical guidelines and expert statements are now available to assist in the analysis and reporting of studies in some biomedical disciplines. We present here a more progressive resource for sample-based studies, meta-analyses, and case studies in sports medicine and exercise science. We offer forthright advice on the following controversial or novel issues: using precision of estimation for inferences about population effects in preference to null-hypothesis testing, which is inadequate for assessing clinical or practical importance; justifying sample size via acceptable precision or confidence for clinical decisions rather than via adequate power for statistical significance; showing SD rather than SEM, to better communicate the magnitude of differences in means and nonuniformity of error; avoiding purely nonparametric analyses, which cannot provide inferences about magnitude and are unnecessary; using regression statistics in validity studies, in preference to the impractical and biased limits of agreement; making greater use of qualitative methods to enrich sample-based quantitative projects; and seeking ethics approval for public access to the depersonalized raw data of a study, to address the need for more scrutiny of research and better meta-analyses. Advice on less contentious issues includes the following: using covariates in linear models to adjust for confounders, to account for individual differences, and to identify potential mechanisms of an effect; using log transformation to deal with nonuniformity of effects and error; identifying and deleting outliers; presenting descriptive, effect, and inferential statistics in appropriate formats; and contending with bias arising from problems with sampling, assignment, blinding, measurement error, and researchers' prejudices. This article should advance the field by stimulating debate, promoting innovative approaches, and serving as a useful checklist for authors, reviewers, and editors.

  14. Studies of elementary particles: Progress report and proposal

    International Nuclear Information System (INIS)

    Chapman, J.W.

    1988-01-01

    This progress report discusses the following High Energy Physics topics: the IMB/MIA detector; the MKII/HRS detector; the cosmic gamma-ray experiment; computer and instrumentation services; the MACRO detector; the DO detector; and spin physics

  15. Memphis State University Center for Nuclear Studies progress report

    International Nuclear Information System (INIS)

    1975-11-01

    Progress made on the development of specialized education programs for the nuclear industry through the month of October, 1975, is outlined. The survey of the nuclear industry includes manpower resources and requirements of nuclear industry, annual training requirements of nuclear plants, and the educational curriculum for nuclear plant operational staff. Also discussed are the general organization of the project, student enrollment and progress and industrial participation

  16. Study of progressive depigmentation of dog′s muzzle

    Directory of Open Access Journals (Sweden)

    Shah K

    1991-01-01

    Full Text Available A new animal model is developed using dog′s muzzle to demonstrate progressive depigmen-tation after birth. Dog′s muzzle is heavily pigmented with pigment melanin and looks black in colour. Progressive depigmentation was observed two months after birth in a pup born with a depigmented mucous membrane of the mouth and lips. This resembles the vitiligo of humans.

  17. Progress on the Design of the Storage Ring Vacuum System for the Advanced Photon Source Upgrade Project

    Energy Technology Data Exchange (ETDEWEB)

    Stillwell, B.; Billett, B.; Brajuskovic, B.; Carter, J.; Kirkus, E.; Lale, M.; Lerch, J.; Noonan, J.; O' Neill, M.; Rocke, B.; Suthar, K.; Walters, D.; Wiemerslage, G.; Zientek, J.

    2017-06-20

    Recent work on the design of the storage ring vacuum system for the Advanced Photon Source Upgrade project (APS-U) includes: revising the vacuum system design to accommodate a new lattice with reverse bend magnets, modifying the designs of vacuum chambers in the FODO sections for more intense incident synchrotron radiation power, modifying the design of rf-shielding bellows liners for better performance and reliability, modifying photon absorber designs to make better use of available space, and integrated planning of components needed in the injection, extraction and rf cavity straight sections. An overview of progress in these areas is presented.

  18. A nationwide quality improvement project to accelerate Ghana's progress toward Millennium Development Goal Four: design and implementation progress.

    Science.gov (United States)

    Twum-Danso, Nana A Y; Akanlu, George B; Osafo, Enoch; Sodzi-Tettey, Sodzi; Boadu, Richard O; Atinbire, Solomon; Adondiwo, Ane; Amenga-Etego, Isaac; Ashagbley, Francis; Boadu, Eric A; Dasoberi, Ireneous; Kanyoke, Ernest; Yabang, Elma; Essegbey, Ivan T; Adjei, George A; Buckle, Gilbert B; Awoonor-Williams, J Koku; Nang-Beifubah, Alexis; Twumasi, Akwasi; McCannon, C Joseph; Barker, Pierre M

    2012-12-01

    The gap between evidence-based guidelines and practice of care is reflected, in low- and middle-income countries, by high rates of maternal and child mortality and limited effectiveness of large-scale programing to decrease those rates. We designed a phased, rapid, national scale-up quality improvement (QI) intervention to accelerate the achievement of Millennium Development Goal Four in Ghana. Our intervention promoted systems thinking, active participation of managers and frontline providers, generation and testing of local change ideas using iterative learning from transparent district and local data, local ownership and sustainability. After 50 months of implementation, we have completed two prototype learning phases and have begun regional spread phases to all health facilities in all 38 districts of the three northernmost regions and all 29 Catholic hospitals in the remaining regions of the country. To accelerate the spread of improvement, we developed 'change packages' of rigorously tested process changes along the continuum of care from pregnancy to age 5 in both inpatient and outpatient settings. The primary successes for the project so far include broad and deep adoption of QI by local stakeholders for improving system performance, widespread capacitation of leaders, managers and frontline providers in QI methods, incorporation of local ideas into change packages and successful scale-up to approximately 25% of the country's districts in 3 years. Implementation challenges include variable leadership uptake and commitment at the district level, delays due to recruiting and scheduling barriers, weak data systems and repeated QI training due to high staff turnover.

  19. FY 2017-Progress Report on the Design and Construction of the Sodium Loop SMT-3

    Energy Technology Data Exchange (ETDEWEB)

    Natesan, K. [Argonne National Lab. (ANL), Argonne, IL (United States); Momozaki, Y. [Argonne National Lab. (ANL), Argonne, IL (United States)

    2017-09-01

    information is being transmitted to the tank fabricator. The SMT-3 loop will be located in Building 206 adjacent to the currently operating SMT-2 loop. In addition, we have demolished the aged power supply system in Building 206 and installed a new transformer, wiring, and power panels for the new loop. Procurement of some of the long lead items such as valves, EM pumps, EM flowmeters, etc. is in progress and will continue in FY 2018. The construction of components such as cold trap, economizers, piping arrangement etc. will be performed in the central shops at ANL. About 150 liters of sodium for the loop will be procured in early FY2018. The loop system is designed to circulate sodium through the sample tanks and the associated loop without an operator for an extended period of time. With the three sodium loops (with single-tank, dual-tank and four–tanks), materials can be tested at different sodium temperatures, and large tensile, creep, fatigue, creep-fatigue, and fracture toughness specimens can be exposed to sodium for extended periods of time and generate data on mechanical properties in support of ASME Code Qualification and USNRC Licensing of advanced Alloy 709 for use as a structural material in SFRs.

  20. Progress in safeguards by design (SBD) by the United States National Nuclear Security Administration (NNSA)

    International Nuclear Information System (INIS)

    Long, J.D.

    2013-01-01

    The IAEA has described the Safeguards by Design (SBD) concept as an approach in which international safeguards are fully integrated into the design process of a new nuclear facility from the initial planning through design, construction, operation, and decommissioning. Often, international safeguards features are added following completion of the facility design. Earlier consideration of safeguards features has the potential to reduce the need for costly re-designs or retrofits of the facility and can result in a more efficient and effective safeguards design. The U.S. Department of Energy's National Nuclear Security Administration (NNSA) initiated a project in 2008 through its Next Generation Safeguards Initiative (NGSI) to establish a global norm for the use of SBD. The NGSI SBD program is evolving in parallel with a similar effort at the IAEA, while taking into account the IAEA's SBD achievements and future plans. The NGSI program includes DOE laboratory studies, international workshops, engagement with industry and the IAEA, and setting an example through its planned use in new nuclear facilities in the United States. Consistent with this effort, the NGSI program has sponsored 'Lessons Learned' studies and the preparation of facility-specific SBD Guidance documents. The NGSI program also takes into account successes that the NNSA has had with implementing safeguards early into facility designs within the U.S. The purpose of this paper is the presentation of the most recent developments in SBD under NGSI within the U.S. as well as the presentation of 'Lessons Learned' integrating safeguards into new nuclear facility designs of the U.S. Nuclear Security Enterprise (NSE), namely the Uranium Processing Facility (UPF) project at the Y-12 National Security Complex in Oak Ridge, Tennessee and to discuss its relevance to international safeguards. The paper is followed by the slides of the presentation. (author)

  1. Progress in study of a medical reactor for boron neutron capture therapy

    International Nuclear Information System (INIS)

    Sasaki, Makoto; Hirota, Jitsuya; Tamao, Shigeo; Kanda, Keiji; Mishima, Yutaka.

    1993-01-01

    A design study of a medical reactor for Boron Neutron Capture Therapy has made progress. Main specifications of the reactor are as follows; thermal power of 2 MW, water cooling by natural convection, semitight core of hexagonal lattice, UO 2 fuel rod of 9.5 mm diameter and no refueling in the reactor-life. Three horizontal and one vertical neutron beam holes are to be provided for simultaneous treatments by thermal and epithermal neutrons and for further biomedical research. The design objectives for the beam holes are to deliver the therapeutic doses in a modest time (30 to 60 min) with minimal fast neutron and gamma contaminants. The n-γ coupling Sn transport calculations have been carried out using n-21 and γ-9 group cross sections on 2-dim. practical models. The calculated results indicate that the design objectives will be achievable even if the thermal power of the reactor is reduced to 1 MW. (author)

  2. Design and development of a learning progression about stellar structure and evolution

    Directory of Open Access Journals (Sweden)

    Arturo Colantonio

    2018-06-01

    Full Text Available [This paper is part of the Focused Collection on Astronomy Education Research.] In this paper we discuss the design and development of a learning progression (LP to describe and interpret students’ understanding about stellar structure and evolution (SSE. The LP is built upon three content dimensions: hydrostatic equilibrium; composition and aggregation state; functioning and evolution. The data to build up the levels of the hypothetical LP (LP1 came from a 45-minute, seven-question interview, with 33 high school students previously taught about the topic. The questions were adapted from an existing multiple-choice instrument. Data were analyzed using Minstrell’s “facets” approach. To assess the validity of LP1, we designed a twelve-hour teaching module featuring paper-and-pencil tasks and practical activities to estimate the stellar structure and evolution parameters. Twenty high school students were interviewed before and after the activities using the same interview protocol. Results informed a revision of LP1 (LP2 and, in parallel, of the module. The revised module included supplementary activities corresponding to changes made to LP1. We then assessed LP2 with 30 high school students through the same interview, submitted before and after the teaching intervention. A final version of the LP (LP3 was then developed drawing on students’ emerging reasoning strategies. This paper contributes to research in science education by providing an example of the iterative development of the instruction required to support the student thinking that LPs’ levels describe. Concerning astronomy education research, our findings can inform suitable instructional activities more responsive to students’ reasoning strategies about stellar structure and evolution.

  3. Pion correlations and calorimeter design for high energy heavy ion collisions. Progress report

    International Nuclear Information System (INIS)

    Wolf, K.L.

    1997-01-01

    Data analysis is in progress for recent experiments performed by the NA44 collaboration with the first running of 160 A GeV 208 Pb-induced reactions at the CERN SPS. Identified singles spectra were taken for pions, kaons, protons, deuterons, antiprotons and antideuterons. Two-pion interferometry measurements were made for semi-central-triggered 208 Pb + Pb collisions. An updated multi-particle spectrometer allows high statistics data sets of identified particles to be collected near mid-rapidity. A second series of experiments will be performed in the fall of 1995 with more emphasis on identical kaon interferometry and on the measurement of rare particle spectra and correlations. Modest instrumentation upgrades by TAMU are designed to increase the trigger function for better impact parameter selection and improved collection efficiency of valid events. An effort to achieve the highest degree of projectile-target stopping is outlined and it is argued that an excitation function on the SPS is needed to better understand reaction mechanisms. Analysis of experimental results is in the final stages at LBL in the EOS collaboration for two-pion interferometry in the 1.2 A GeV Au + Au reaction, taken with full event characterization

  4. Progress in preliminary studies at Ottana Solar Facility

    Science.gov (United States)

    Demontis, V.; Camerada, M.; Cau, G.; Cocco, D.; Damiano, A.; Melis, T.; Musio, M.

    2016-05-01

    The fast increasing share of distributed generation from non-programmable renewable energy sources, such as the strong penetration of photovoltaic technology in the distribution networks, has generated several problems for the management and security of the whole power grid. In order to meet the challenge of a significant share of solar energy in the electricity mix, several actions aimed at increasing the grid flexibility and its hosting capacity, as well as at improving the generation programmability, need to be investigated. This paper focuses on the ongoing preliminary studies at the Ottana Solar Facility, a new experimental power plant located in Sardinia (Italy) currently under construction, which will offer the possibility to progress in the study of solar plants integration in the power grid. The facility integrates a concentrating solar power (CSP) plant, including a thermal energy storage system and an organic Rankine cycle (ORC) unit, with a concentrating photovoltaic (CPV) plant and an electrical energy storage system. The facility has the main goal to assess in real operating conditions the small scale concentrating solar power technology and to study the integration of the two technologies and the storage systems to produce programmable and controllable power profiles. A model for the CSP plant yield was developed to assess different operational strategies that significantly influence the plant yearly yield and its global economic effectiveness. In particular, precise assumptions for the ORC module start-up operation behavior, based on discussions with the manufacturers and technical datasheets, will be described. Finally, the results of the analysis of the: "solar driven", "weather forecasts" and "combined storage state of charge (SOC)/ weather forecasts" operational strategies will be presented.

  5. Reactor Primary Coolant System Pipe Rupture Study. Progress report No. 32, July--December 1974

    International Nuclear Information System (INIS)

    1975-03-01

    The pipe rupture study is designed to extend the understanding of failure-causing mechanisms and to provide improved capability for evaluating reactor piping systems to minimize the probability of failures. Following a detailed review to determine the effort most needed to improve nuclear system piping (Phase I), analytical and experimental efforts (Phase II) were started in 1965. This progress report summarizes the recent accomplishments of a broad program in (a) basic fatigue studies focused on Elastic/Plastic ASME Code Design Rules, (b) at-reactor tests of the effect of primary coolant environment on the fatigue behavior of piping steels, and (c) studies directed at quantifying weld sensitization in T-304 stainless steel. (auth)

  6. [Reaction mechanism studies of heavy ion induced nuclear reactions]: Annual progress report, October 1987

    International Nuclear Information System (INIS)

    Mignerey, A.C.

    1987-10-01

    The experiments which this group has been working on seek to define the reaction mechanisms responsible for complex fragment emission in heavy ion reactions. The reactions studied are La + La, La + Al, and La + Cu at 46.8 MeV/u; and Ne + Ag and Ne + Au reactions at 250 MeV/u. Another experimental program at the Oak Ridge Hollifield Heavy Ion Research Facility (HHIRF) is designed to measure the excitation energy division between reaction products in asymmetric deep inelastic reactions. A brief description is given of progress to date, the scientific goals of this experiment and the plastic phoswich detectors developed for this experiment

  7. Progress in Fast Ignition Studies with Electrons and Protons

    Science.gov (United States)

    MacKinnon, A. J.; Akli, K. U.; Bartal, T.; Beg, F. N.; Chawla, S.; Chen, C. D.; Chen, H.; Chen, S.; Chowdhury, E.; Fedosejevs, R.; Freeman, R. R.; Hey, D.; Higginson, D.; Key, M. H.; King, J. A.; Link, A.; Ma, T.; MacPhee, A. G.; Offermann, D.; Ovchinnikov, V.; Pasley, J.; Patel, P. K.; Ping, Y.; Schumacher, D. W.; Stephens, R. B.; Tsui, Y. Y.; Wei, M. S.; Van Woerkom, L. D.

    2009-09-01

    Isochoric heating of inertially confined fusion plasmas by laser driven MeV electrons or protons is an area of great topical interest in the inertial confinement fusion community, particularly with respect to the fast ignition (FI) concept for initiating burn in a fusion capsule. In order to investigate critical aspects needed for a FI point design, experiments were performed to study 1) laser-to-electrons or protons conversion issues and 2) laser-cone interactions including prepulse effects. A large suite of diagnostics was utilized to study these important parameters. Using cone—wire surrogate targets it is found that pre-pulse levels on medium scale lasers such as Titan at Lawrence Livermore National Laboratory produce long scale length plasmas that strongly effect coupling of the laser to FI relevant electrons inside cones. The cone wall thickness also affects coupling to the wire. Conversion efficiency to protons has also been measured and modeled as a function of target thickness, material. Conclusions from the proton and electron source experiments will be presented. Recent advances in modeling electron transport and innovative target designs for reducing igniter energy and increasing gain curves will also be discussed. In conclusion, a program of study will be presented based on understanding the fundamental physics of the electron or proton source relevant to FI.

  8. A review on progress of man-machine interface system designs for Japanese PWRs

    International Nuclear Information System (INIS)

    Yoshikawa, Hidekazu; Yamamoto, Yoshihiro; Magari, Takayuki.

    1994-01-01

    Historical development of Instrumentation and Control (I and C) system designing for the PWR plants in Kansai Electric Co. Ltd is firstly reviewed with respect to the conventional PWRs in the past, brand-new PWRs (Ohi 3/4 units) and advanced PWRs (APWR) in Japan. The major features of the APWR I and C system design are extensive application of digital computer control technology and advanced man-machine interface in order to enhance safety and reliability of total I and C system and to improve human factors in nuclear power plant operation. Comparative study of the APWR's I and C system design with the EPRI's User Requirement Definitions (URD) resulted in that the current Japanese APWR I and C system design meets generally with the EPRI URD conditions except for those items mainly set by the present national regulatory guidelines. The remaining problems in the current I and C system design are discussed which include the issues on future direction of man-machine interface development. (author)

  9. Local progression and pseudo progression after single fraction or fractionated stereotactic radiotherapy for large brain metastases. A single centre study

    Energy Technology Data Exchange (ETDEWEB)

    Wiggenraad, R.; Verbeek-de Kanter, A.; Mast, M. [Radiotherapy Centre West, The Hague (Netherlands); Molenaar, R. [Diaconessenhuis, Leiden (Netherlands). Dept. of Neurology; Lycklama a Nijeholt, G. [Medical Centre Haagladen, The Hague (Netherlands). Dept. of Radiology; Vecht, C. [Medical Centre Haagladen, The Hague (Netherlands). Dept. of Neurology; Struikmans, H. [Radiotherapy Centre West, The Hague (Netherlands); Leiden Univ. Medical Centre (Netherlands). Dept. of Radiotherapy; Kal, H.B.

    2012-08-15

    Purpose: The 1-year local control rates after single-fraction stereotactic radiotherapy (SRT) for brain metastases > 3 cm diameter are less than 70%, but with fractionated SRT (FSRT) higher local control rates have been reported. The purpose of this study was to compare our treatment results with SRT and FSRT for large brain metastases. Materials and methods: In two consecutive periods, 41 patients with 46 brain metastases received SRT with 1 fraction of 15 Gy, while 51 patients with 65 brain metastases received FSRT with 3 fractions of 8 Gy. We included patients with brain metastases with a planning target volume of > 13 cm{sup 3} or metastases in the brainstem. Results: The minimum follow-up of patients still alive was 22 months. Comparing 1 fraction of 15 Gy with 3 fractions of 8 Gy, the 1-year rates of freedom from any local progression (54% and 61%, p = 0.93) and pseudo progression (85% and 75%, p = 0.25) were not significantly different. Overall survival rates were also not different. Conclusion: The 1-year local progression and pseudo progression rates after 1 fraction of 15 Gy or 3 fractions of 8 Gy for large brain metastases and metastases in the brainstem are similar. For better local control rates, FSRT schemes with a higher biological equivalent dose may be necessary. (orig.)

  10. Local progression and pseudo progression after single fraction or fractionated stereotactic radiotherapy for large brain metastases. A single centre study

    International Nuclear Information System (INIS)

    Wiggenraad, R.; Verbeek-de Kanter, A.; Mast, M.; Molenaar, R.; Lycklama a Nijeholt, G.; Vecht, C.; Struikmans, H.; Leiden Univ. Medical Centre; Kal, H.B.

    2012-01-01

    Purpose: The 1-year local control rates after single-fraction stereotactic radiotherapy (SRT) for brain metastases > 3 cm diameter are less than 70%, but with fractionated SRT (FSRT) higher local control rates have been reported. The purpose of this study was to compare our treatment results with SRT and FSRT for large brain metastases. Materials and methods: In two consecutive periods, 41 patients with 46 brain metastases received SRT with 1 fraction of 15 Gy, while 51 patients with 65 brain metastases received FSRT with 3 fractions of 8 Gy. We included patients with brain metastases with a planning target volume of > 13 cm 3 or metastases in the brainstem. Results: The minimum follow-up of patients still alive was 22 months. Comparing 1 fraction of 15 Gy with 3 fractions of 8 Gy, the 1-year rates of freedom from any local progression (54% and 61%, p = 0.93) and pseudo progression (85% and 75%, p = 0.25) were not significantly different. Overall survival rates were also not different. Conclusion: The 1-year local progression and pseudo progression rates after 1 fraction of 15 Gy or 3 fractions of 8 Gy for large brain metastases and metastases in the brainstem are similar. For better local control rates, FSRT schemes with a higher biological equivalent dose may be necessary. (orig.)

  11. Studies in iodine metabolism. Progress report, 1982-1983

    International Nuclear Information System (INIS)

    Van Middlesworth, L.

    1983-01-01

    Research progress is reported for the period 1982 to 1983 in the following areas: (1) monitoring of animal thyroids for 129 I, 125 I, 131 I, 226 Ra, and 228 Ra; and (2) neonatal hypo-l thyroidism in laboratory rats

  12. Progress report of preliminary studies of beryllium toxicity

    Energy Technology Data Exchange (ETDEWEB)

    Hodge, H.C.

    1947-09-01

    This document was prepared in connection with a symposium of beryllium poisoning held at the Saranac Laboratories and describes progress made and a research program aimed at characterizing the toxicity of beryllium. Seven individual papers in this document are separately indexed and cataloged for the database.

  13. Progresses in studies on radiation treatment of environmental pollutants

    International Nuclear Information System (INIS)

    Wang Min; Shen Zhongqun; Yang Ruiyuan; Ma Hongjuan; Zhao Jun; Wang Wenfeng

    2007-01-01

    The paper gives a review on recent progresses in E-beam purification of flue gases, radiation degra- dation of volatile organic compounds, and radiation treatment of sewerage and industrial wastewater. And research activities in this area at Shanghai Institute of Applied Physics are given in particular details. (authors)

  14. Recent Seismicity in Texas and Research Design and Progress of the TexNet-CISR Collaboration

    Science.gov (United States)

    Hennings, P.; Savvaidis, A.; Rathje, E.; Olson, J. E.; DeShon, H. R.; Datta-Gupta, A.; Eichhubl, P.; Nicot, J. P.; Kahlor, L. A.

    2017-12-01

    The recent increase in the rate of seismicity in Texas has prompted the establishment of an interdisciplinary, interinstitutional collaboration led by the Texas Bureau of Economic Geology which includes the TexNet Seismic Monitoring and Research project as funded by The State of Texas (roughly 2/3rds of our funding) and the industry-funded Center for Integrated Seismicity Research (CISR) (1/3 of funding). TexNet is monitoring and cataloging seismicity across Texas using a new backbone seismic network, investigating site-specific earthquake sequences by deploying temporary seismic monitoring stations, and conducting reservoir modeling studies. CISR expands TexNet research into the interdisciplinary realm to more thoroughly study the factors that contribute to seismicity, characterize the associated hazard and risk, develop strategies for mitigation and management, and develop methods of effective communication for all stakeholders. The TexNet-CISR research portfolio has 6 themes: seismicity monitoring, seismology, geologic and hydrologic description, geomechanics and reservoir modeling, seismic hazard and risk assessment, and seismic risk social science. Twenty+ specific research projects span and connect these themes. We will provide a synopsis of research progress including recent seismicity trends in Texas; Fort Worth Basin integrated studies including geological modeling and fault characterization, fluid injection data syntheses, and reservoir and geomechanical modeling; regional ground shaking characterization and mapping, infrastructure vulnerability assessment; and social science topics of public perception and information seeking behavior.

  15. Glaucoma Monitoring in a Clinical Setting Glaucoma Progression Analysis vs Nonparametric Progression Analysis in the Groningen Longitudinal Glaucoma Study

    NARCIS (Netherlands)

    Wesselink, Christiaan; Heeg, Govert P.; Jansonius, Nomdo M.

    Objective: To compare prospectively 2 perimetric progression detection algorithms for glaucoma, the Early Manifest Glaucoma Trial algorithm (glaucoma progression analysis [GPA]) and a nonparametric algorithm applied to the mean deviation (MD) (nonparametric progression analysis [NPA]). Methods:

  16. Reactor primary coolant system pipe rupture study. Progress report No. 33, January--June 1975

    International Nuclear Information System (INIS)

    1975-10-01

    The pipe rupture study is designed to extend the understanding of failure-causing mechanisms and to provide improved capability for evaluating reactor piping systems to minimize the probability of failures. Following a detailed review to determine the effort most needed to improve nuclear system piping (Phase 1), analytical and experimental efforts (Phase 2) were started in 1965. This progress report summarizes the recent accomplishments of a broad program in (a) basic fatigue crack growth rate studies focused on LWR primary piping materials in a simulated BWR primary coolant environment, (b) at-reactor tests of the effect of primary coolant environment on the fatigue behavior of piping steels, (c) studies directed at quantifying weld sensitization in Type 304 stainless steel, (d) support studies to characterize the electrochemical potential behavior of a typical BWR primary water environment and (e) special tests related to simulation of fracture surfaces characteristic of IGSCC field failures

  17. Progress in blanket designs using SiCf/SiC composites

    International Nuclear Information System (INIS)

    Giancarli, L.; Golfier, H.; Nishio, S.; Raffray, R.; Wong, C.; Yamada, R.

    2002-01-01

    This paper summarizes the most recent design activities concerning the use of SiC f /SiC composite as structural material for fusion power reactor breeding blanket. Several studies have been performed in the past. The most recent proposals are the TAURO blanket concept in the European Union, the ARIES-AT concept in the US, and DREAM concept in Japan. The first two concepts are self-cooled lithium-lead blankets, while DREAM is an helium-cooled beryllium/ceramic blanket. Both TAURO and ARIES-AT blankets are essentially formed by a SiC f /SiC box acting as a container for the lithium-lead which has the simultaneous functions of coolant, tritium breeder, neutron multiplier and, finally, tritium carrier. The DREAM blanket is characterized by small modules using pebble beds of Be as neutron multiplier material, of Li 2 O (or other lithium ceramics) as breeder material and of SiC as shielding material. The He coolant path includes a flow through the pebble beds and a porous partition wall. For each blanket, this paper describes the main design features and performances, the most recent design improvements, and the proposed manufacturing routes in order to identify specific issues and requirements for the future R and D on SiC f /SiC

  18. Progress in the application study of biliary endoprosthesis

    International Nuclear Information System (INIS)

    Liu Yujin; Yang Renjie

    2009-01-01

    Biliary endoprosthesis, including plastic stents and metallic stents, have been widely used in the management of various benign or malignant bile duct stenosis. Although the short-term effect is most satisfactory, the long-term result is unsatisfactory because of the displacement and restenosis of the stent. Metallic stent is superior to plastic stent in keeping the stent open for long time and the technique has been improved gradually. This paper aims to make a review of the related literatures and to summarize the recent progress in the applied research. (authors)

  19. Progress study of the cardiac damage in Duchenne muscular dystrophy

    Directory of Open Access Journals (Sweden)

    ZHANG Yao

    2013-05-01

    Full Text Available Duchenne muscular dystrophy (DMD is a fatal muscular disease with rapid progression in children. Most patients die of respiratory and circulatory failure before the age of 20 if there is no systematic treatment. Now the heart problem in this disease has become increasingly prominent, and is thought to be closely associated with certain dystrophin exon deletion. We would like to review the epidemiology, relevance of dystrophin, pathogenesis, clinical manifestations and pathological features, as well as early prevention and treatment of DMD.

  20. Recent Progress in the Study of Topological Semimetals

    Science.gov (United States)

    Bernevig, Andrei; Weng, Hongming; Fang, Zhong; Dai, Xi

    2018-04-01

    The topological semimetal is a new, theoretically predicted and experimentally discovered, topological state of matter. In one of its several realizations, the topological semimetal hosts Weyl fermions, elusive particles predicted more than 85 years ago, sought after in high-energy experiments, but only recently found in a condensed-matter setting. In the present review, we catalogue the most recent progress in this fast-developing research field. We give special attention to topological invariants and the material realization of three different types of topological semimetal. We also discuss various photo emission, transport and optical experimental observables that characterize the appearance of topological semimetal phases.

  1. LMFBR fuel cycle studies progress report, August 1972, No. 42

    International Nuclear Information System (INIS)

    Unger, W.E.; Blanco, R.E.; Crouse, D.J.; Irvine, A.R.; Watson, C.D.

    1972-10-01

    This report continues a series outlining progress in the development of methods for reprocessing of LMFBR fuels. Development work is reported on problems of irradiated fuel transport to the processing facility, the dissolution of the fuel and the chemical recovery of PuO 2 --UO 2 values, the containment of volatile fission products, product purification, conversion of fuel processing plant product nitrate solutions to solids suitable for shipping and for subsequent fuel fabrication. Pertinent experimental results are presented for the information of those immediately concerned with the field. Detailed description of experimental work and data are included in the topical reports and in the Chemical Technology Division Annual Reports

  2. Progress on the conceptual design of a mirror hybrid fusion--fission reactor

    International Nuclear Information System (INIS)

    Moir, R.W.; Lee, J.D.; Burleigh, R.J.

    1975-01-01

    A conceptual design study was made of a fusion-fission reactor for the purpose of producing fissile material and electricity. The fusion component is a D-T plasma confined by a pair of magnetic mirror coils in a Yin-Yang configuration and is sustained by neutral beam injection. The neutrons from the fusion plasma drive the fission assembly which is composed of natural uranium carbide fuel rods clad with stainless steel and helium cooled. It was shown conceptually how the reactor might be built using essentially present-day technology and how the uranium-bearing blanket modules can be routinely changed to allow separation of the bred fissile fuel

  3. Recycler ring conceptual design study

    International Nuclear Information System (INIS)

    Jackson, G.

    1995-01-01

    The Tevatron Collider provides the highest center of mass energy collisions in the world. To fully exploit this unique tool, Fermilab is committed to a program of accelerator upgrades for the purpose of increasing the Collider luminosity. Over the past 7 years the luminosity has been increased from a peak of 1.6x10 30 cm -2 sec -1 in 1989 to over 3x10 31 cm -2 sec -1 during 1995. The Main Injector will supply a larger flux of protons for antiproton production and more intense proton bunches for use in the Collider, and this is expected to increase the peak luminosity to close to 1x10 32 cm -2 sec -1 . Further increases in luminosity will require additional upgrades to the Fermilab accelerator complex. This report documents the design of a new fixed-energy storage ring to be placed in the Main Injector tunnel which will provide an initial factor of 2 increase to 2x10 32 cm -2 sec -1 , and ultimately provide the basis for an additional order of magnitude luminosity increase up to 1x10 33 cm -2 sec -1

  4. Vehicle systems design optimization study

    Energy Technology Data Exchange (ETDEWEB)

    Gilmour, J. L.

    1980-04-01

    The optimization of an electric vehicle layout requires a weight distribution in the range of 53/47 to 62/38 in order to assure dynamic handling characteristics comparable to current production internal combustion engine vehicles. It is possible to achieve this goal and also provide passenger and cargo space comparable to a selected current production sub-compact car either in a unique new design or by utilizing the production vehicle as a base. Necessary modification of the base vehicle can be accomplished without major modification of the structure or running gear. As long as batteries are as heavy and require as much space as they currently do, they must be divided into two packages - one at front under the hood and a second at the rear under the cargo area - in order to achieve the desired weight distribution. The weight distribution criteria requires the placement of batteries at the front of the vehicle even when the central tunnel is used for the location of some batteries. The optimum layout has a front motor and front wheel drive. This configuration provides the optimum vehicle dynamic handling characteristics and the maximum passsenger and cargo space for a given size vehicle.

  5. Progress report of the French program, and basic design of the Jules Horowitz reactor

    International Nuclear Information System (INIS)

    Ballagny, A.

    1998-01-01

    Since the SILOE reactor was shutdown on December 23, 1997, France has been entirely depending on the OSIRIS reactor to conduct the material and fuel irradiation programmes necessary to the evolution of its nuclear power plants and to prepare the future by analysing further reactor designs which might originate in other strategies, namely in the fuel cycle field. The Jules Horowitz reactor, which operation scheduled to start in 2006, will last 50 years, must cover all irradiation needs including, as far as possible, those related to fast breeder reactor studies, more particularly since the SUPERPHENIX reactor shutdown was announced. RJH reactor studies therefore focus on the increase of flux levels and the search for the limit performance of U 3 Si 2 based MTR fuels. (author)

  6. Advanced Turbine Systems (ATS) program conceptual design and product development. Quarterly progress report, December 1, 1995--February 29, 1996

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-06-01

    This report describes the overall program status of the General Electric Advanced Gas Turbine Development program, and reports progress on three main task areas. The program is focused on two specific products: (1) a 70-MW class industrial gas turbine based on the GE90 core technology, utilizing a new air cooling methodology; and (2) a 200-MW class utility gas turbine based on an advanced GE heavy-duty machine, utilizing advanced cooling and enhancement in component efficiency. The emphasis for the industrial system is placed on cycle design and low emission combustion. For the utility system, the focus is on developing a technology base for advanced turbine cooling while achieving low emission combustion. The three tasks included in this progress report are on: conversion to a coal-fueled advanced turbine system, integrated program plan, and design and test of critical components. 13 figs., 1 tab.

  7. Spiral 2: preliminary design study

    International Nuclear Information System (INIS)

    2001-11-01

    The scientific council of GANIL asked to perform a comparative study on the production methods based on gamma induced fission and rapid-neutron induced fission concerning the nature and the intensity of the neutron-rich products. The production rate expected should be around 10 13 fissions per second. The study should include the implantation and the costs of the concerned accelerators. The scientific committee recommended also to study the possibility to re-inject the radioactive beams of SPIRAL-II in the cyclotrons available at GANIL in order to give access to an energy range from 1.7 to 100 MeV/nucleon. For that purpose, some study groups have been formed to evaluate the possibility of such a project in the different components: physics case, target-ion sources, drivers, post-acceleration and general infrastructure. The organization of the project study is given at the end of this report. The following report presents an overview of the study. Particularly the total costs have been assessed according to 3 options for the driver: 38.0*10 6 euros for a 40 MeV deuteron linac, 18.7*10 6 euros for a 45 MeV electron linac, and 29.1*10 6 euros for a 80 MeV deuteron cyclotron

  8. Spiral 2: preliminary design study

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-11-15

    The scientific council of GANIL asked to perform a comparative study on the production methods based on gamma induced fission and rapid-neutron induced fission concerning the nature and the intensity of the neutron-rich products. The production rate expected should be around 10{sup 13} fissions per second. The study should include the implantation and the costs of the concerned accelerators. The scientific committee recommended also to study the possibility to re-inject the radioactive beams of SPIRAL-II in the cyclotrons available at GANIL in order to give access to an energy range from 1.7 to 100 MeV/nucleon. For that purpose, some study groups have been formed to evaluate the possibility of such a project in the different components: physics case, target-ion sources, drivers, post-acceleration and general infrastructure. The organization of the project study is given at the end of this report. The following report presents an overview of the study. Particularly the total costs have been assessed according to 3 options for the driver: 38.0*10{sup 6} euros for a 40 MeV deuteron linac, 18.7*10{sup 6} euros for a 45 MeV electron linac, and 29.1*10{sup 6} euros for a 80 MeV deuteron cyclotron.

  9. Shock ignition: a brief overview and progress in the design of robust targets

    International Nuclear Information System (INIS)

    Atzeni, S; Marocchino, A; Schiavi, A

    2015-01-01

    Shock ignition is a laser direct-drive inertial confinement fusion (ICF) scheme in which the stages of compression and hot spot formation are partly separated. The fuel is first imploded at a lower velocity than in conventional ICF, reducing the threats due to Rayleigh–Taylor instability. Close to stagnation, an intense laser spike drives a strong converging shock, which contributes to hot spot formation. This paper starts with a brief overview of the theoretical studies, target design and experimental results on shock ignition. The second part of the paper illustrates original work aiming at the design of robust targets and computation of the relevant gain curves. Following Chang et al (2010 Phys. Rev. Lett. 104 135002) a safety factor for high gain, ITF* (analogous to the ignition threshold factor ITF introduced by Clark et al (2008 Phys. Plasmas 15 056305)), is evaluated by means of parametric 1D simulations with artificially reduced reactivity. SI designs scaled as in Atzeni et al (2013 New J. Phys. 15 045004) are found to have nearly the same ITF*. For a given target, such ITF* increases with implosion velocity and laser spike power. A gain curve with a prescribed ITF* can then be simply generated by upscaling a reference target with that value of ITF*. An interesting option is scaling in size by reducing the implosion velocity to keep the ratio of implosion velocity to self-ignition velocity constant. At a given total laser energy, targets with higher ITF* are driven to higher implosion velocity and achieve a somewhat lower gain. However, a 1D gain higher than 100 is achieved at an (incident) energy below 1 MJ, an implosion velocity below 300 km s −1 and a peak incident power below 400 TW. 2D simulations of mispositioned targets show that targets with a higher ITF* indeed tolerate larger displacements. (paper)

  10. Approximal secondary caries lesion progression, a 20-week in situ study

    NARCIS (Netherlands)

    Thomas, R. Z.; Ruben, J. L.; ten Bosch, J. J.; Fidler, V.; Huysmans, M. C. D. N. J. M.

    2007-01-01

    There is no consensus about the definition and progression of outer and wall lesions in secondary caries. In this study we investigated whether lesion progression is influenced by an adjacent composite restoration and whether wall lesions develop at the composite-tooth interface. In order to study

  11. Progress on study of nuclear data theory and related fields at the Theory Group of CNDC

    Energy Technology Data Exchange (ETDEWEB)

    Zhigang, Ge [China Nuclear Data Center, CIAE (China)

    1996-06-01

    The Theory Group of CNDC (China Nuclear Data Center) has made a lot of progress in nuclear reaction theory and its application as well as many other related fields in 1995. The recent progress in nuclear reaction theory study and its applications, the recent progress in the nuclear data calculation and related code development are introduced. The production rate of radioactive nuclear beam induced by 70 MeV protons on {sup 72}Ge target were calculated. The calculated results are presented.

  12. TLEP design study forges ahead

    CERN Multimedia

    Alain Blondel & Mike Koratzinos

    2013-01-01

    As the Future Circular Collider (FCC) study is launched, one of its component parts, TLEP, enjoys a successful workshop at CERN. The FCC study looks at all options for a future circular collider with the emphasis on a hadron machine with TLEP as a possible intermediate step.   The poster of the sixth TLEP workshop that took place at CERN. Japanese artist Kazuya Akimoto kindly agreed to the use of one of his works as the basis for the poster’s backdrop. October 16 to 18 saw a three-day workshop on TLEP, the sixth in the series. The workshop took place at CERN and was well attended, informative and stimulating. To name just one of the influential people present, Herwig Schopper, ex-Director General of CERN and instrumental in the approval, construction and success of LEP, was among the participants. But what exactly is TLEP? The name was, somehow serendipitously, coined from future lepton collider option studies and stands for triple-LEP, a machine three times the size of LEP. But th...

  13. Progressive design methodology for complex engineering systems based on multiobjective genetic algorithms and linguistic decision making

    NARCIS (Netherlands)

    Kumar, P.; Bauer, P.

    2008-01-01

    This work focuses on a design methodology that aids in design and development of complex engineering systems. This design methodology consists of simulation, optimization and decision making. Within this work a framework is presented in which modelling, multi-objective optimization and multi

  14. Exploratory Shaft Facility design basis study report

    International Nuclear Information System (INIS)

    Langstaff, A.L.

    1987-01-01

    The Design Basis Study is a scoping/sizing study that evaluated the items concerning the Exploratory Shaft Facility Design including design basis values for water and methane inflow; flexibility of the design to support potential changes in program direction; cost and schedule impacts that could result if the design were changed to comply with gassy mine regulations; and cost, schedule, advantages and disadvantages of a larger second shaft. Recommendations are proposed concerning water and methane inflow values, facility layout, second shaft size, ventilation, and gassy mine requirements. 75 refs., 3 figs., 7 tabs

  15. Collective design in 3D printing: A large scale empirical study of designs, designers and evolution

    DEFF Research Database (Denmark)

    Özkil, Ali Gürcan

    2017-01-01

    This paper provides an empirical study of a collective design platform (Thingiverse); with the aim of understanding the phenomenon and investigating how designs concurrently evolve through the large and complex network of designers. The case study is based on the meta-data collected from 158 489 ...

  16. EBTS: DESIGN AND EXPERIMENTAL STUDY

    International Nuclear Information System (INIS)

    PIKIN, A.; ALESSI, J.; BEEBE, E.; KPONOU, A.; PRELEC, K.; KUZNETSOV, G.; TIUNOV, M.

    2000-01-01

    Experimental study of the BNL Electron Beam Test Stand (EBTS), which is a prototype of the Relativistic Heavy Ion Collider (RHIC) Electron Beam Ion Source (EBIS), is currently underway. The basic physics and engineering aspects of a high current EBIS implemented in EBTS are outlined and construction of its main systems is presented. Efficient transmission of a 10 A electron beam through the ion trap has been achieved. Experimental results on generation of multiply charged ions with both continuous gas and external ion injection confirm stable operation of the ion trap

  17. ITER [International Thermonuclear Experimental Reactor] reactor building design study

    International Nuclear Information System (INIS)

    Thomson, S.L.; Blevins, J.D.; Delisle, M.W.

    1989-01-01

    The International Thermonuclear Experimental Reactor (ITER) is at the midpoint of a two-year conceptual design. The ITER reactor building is a reinforced concrete structure that houses the tokamak and associated equipment and systems and forms a barrier between the tokamak and the external environment. It provides radiation shielding and controls the release of radioactive materials to the environment during both routine operations and accidents. The building protects the tokamak from external events, such as earthquakes or aircraft strikes. The reactor building requirements have been developed from the component designs and the preliminary safety analysis. The equipment requirements, tritium confinement, and biological shielding have been studied. The building design in progress requires continuous iteraction with the component and system designs and with the safety analysis. 8 figs

  18. Development of an extended-burnup Mark B design. Second semiannual progress report, January-June 1979

    International Nuclear Information System (INIS)

    1979-11-01

    The immediate goal of the DOE/AP and L/B and W project is to extend the burnup of light water reactor fuel assemblies beyond present limits to 50,000 MWd/mtU batch average burnup. Fuel management plans and fuel designs are being directed to attain the increased burnup limits. Lead-test assemblies of extended-burnup designs will be manufactured, irradiated in a commercial pressurized water reactor, and examined to support extended-burnup fuel cycles. This report, covering the period from January through June 1979, is the second semiannual progress report for the program. Efforts have included analyses of extended-burnup fuel cycles, developed of both annular fuel pellet and segmented rod designs, and design of a nondestructive post-irradiation examination system

  19. Progress on first-principles-based materials design for hydrogen storage.

    Science.gov (United States)

    Park, Noejung; Choi, Keunsu; Hwang, Jeongwoon; Kim, Dong Wook; Kim, Dong Ok; Ihm, Jisoon

    2012-12-04

    This article briefly summarizes the research activities in the field of hydrogen storage in sorbent materials and reports our recent works and future directions for the design of such materials. Distinct features of sorption-based hydrogen storage methods are described compared with metal hydrides and complex chemical hydrides. We classify the studies of hydrogen sorbent materials in terms of two key technical issues: (i) constructing stable framework structures with high porosity, and (ii) increasing the binding affinity of hydrogen molecules to surfaces beyond the usual van der Waals interaction. The recent development of reticular chemistry is summarized as a means for addressing the first issue. Theoretical studies focus mainly on the second issue and can be grouped into three classes according to the underlying interaction mechanism: electrostatic interactions based on alkaline cations, Kubas interactions with open transition metals, and orbital interactions involving Ca and other nontransitional metals. Hierarchical computational methods to enable the theoretical predictions are explained, from ab initio studies to molecular dynamics simulations using force field parameters. We also discuss the actual delivery amount of stored hydrogen, which depends on the charging and discharging conditions. The usefulness and practical significance of the hydrogen spillover mechanism in increasing the storage capacity are presented as well.

  20. High energy physics studies. Progress report. Part I. Experimental program. Part II. Theoretical program

    International Nuclear Information System (INIS)

    Romanowski, T.A.; Tanaka, K.; Wada, W.W.

    1978-01-01

    Experimental Program: assembly of an experiment as Fermilab E-531 to measure decay lifetimes, with tagged emulsion of charmed particles produced by high energy neutrinos was finished, and data taking now is in progress. An experiment to measure prompt neutrino production at Fermilab, E-613, was approved and detailed design of it is continuing. Search for parity violation in scattering of polarized protons, an experiment E-446-ZGS at ANL, was performed with the sensitivity of 10 -6 for detection of that process and yielded null results. Another run with improved sensitivity of 10 -7 is in preparation. Data analysis of the neutrino experiment E-310 at Fermilab will continue. Trimuon events, a new discovery, were identified in those data. Analysis of data on meson production from experiments performed at the ZGS--ANL, E-397, E-420 and E-428, with charged and neutral spectrometer will continue. A new relatively broad resonance (T approx. 70 MeV) with quantum numbers IJ/sup P/ = 00 -1 was discovered in the data from E-397. Analysis of beta decay of polarized Σ - hyperons is in progress. Participation in the design of the experimental areas for the Isabelle colliding proton beam accelerator will continue. Theoretical Program: topics of current interest in particle theory which will be investigated in the coming year are: the instanton-anti-instanton QCD gauge fields, discrete symmetries which may determine quark masses in the SU(2) x U(1) model, calculation of charmed meson production in e + e - collisions and formation of gluon jets, Higgs boson production in pp collisions, calculation of Higgs boson mass in terms of vector boson mass, study of Lagrangians with gauge and Higgs scalar fields, investigation of Faddeev--Popov determinants as related to quantum chromodynamics, a study of quantum flavor dynamics and anomalies in the axial vector Ward identity and a study of super symmetry as a part of a realistic model of leptonic interactions

  1. High energy physics studies progress report. Part I. Experimental program

    International Nuclear Information System (INIS)

    1977-01-01

    The experimental program of research, including Assembly of an experiment at Fermilab E-351 to measure decay lifetimes, with tagged emulsion, of charmed particles produced by high energy neutrinos will continue. A data-taking run will take place in the coming fiscal year. Participation in the neutrino experiment E-310, Fermilab-Harvard-Pennsylvania-Rutgers-Wisconsin, will also continue. Data analysis from several experiments performed in the recent past at the ZGS ANL is in progress and will be pursued. These experiments are, E-397, E-420 and E-428 performed with the Charged and Neutral Spectrometer, and E-347 with the Σ/sub β/ Spectrometer. Plans are in the making to collaborate with a polarized proton experiment at the ZGS. New approaches to ''third generation'' neutrino experiments at Fermilab are being discussed by the whole high energy group. Ideas of pursuing experiments at the AGS-BNL with the Σ/sub β/ Spectrometer are explored. The theoretical research program covers topics of current interest in particle theory which will be investigated in the coming year; namely, the role of instantons in quantum chromodynamics, Higgs Lagrangian involving scalar fields, phenomenology of neutrino physics and in particular the nature of trimuon production, higher order symmetries like SU(3) x U(1) SU(5) and SU(6), dynamics of high energy diffractive scattering, classical solutions to the gauge field theories

  2. Mobile Variable Depth Sampling System Design Study

    International Nuclear Information System (INIS)

    BOGER, R.M.

    2000-01-01

    A design study is presented for a mobile, variable depth sampling system (MVDSS) that will support the treatment and immobilization of Hanford LAW and HLW. The sampler can be deployed in a 4-inch tank riser and has a design that is based on requirements identified in the Level 2 Specification (latest revision). The waste feed sequence for the MVDSS is based on Phase 1, Case 3S6 waste feed sequence. Technical information is also presented that supports the design study

  3. Mobile Variable Depth Sampling System Design Study

    Energy Technology Data Exchange (ETDEWEB)

    BOGER, R.M.

    2000-08-25

    A design study is presented for a mobile, variable depth sampling system (MVDSS) that will support the treatment and immobilization of Hanford LAW and HLW. The sampler can be deployed in a 4-inch tank riser and has a design that is based on requirements identified in the Level 2 Specification (latest revision). The waste feed sequence for the MVDSS is based on Phase 1, Case 3S6 waste feed sequence. Technical information is also presented that supports the design study.

  4. Incidence and progression rates of age-related maculopathy: the Rotterdam Study

    NARCIS (Netherlands)

    J.J.M. Willemse-Assink (Jacqueline); R. van Leeuwen (Redmer); R.C.W. Wolfs (Roger); J.R. Vingerling (Hans); Th. Stijnen (Theo); P.T.V.M. de Jong (Paulus); C.C.W. Klaver (Caroline); A. Hofman (Albert)

    2001-01-01

    textabstractPURPOSE: To describe the incidence rate of age-related macular degeneration (AMD) and the progression rates of early stages of age-related maculopathy (ARM), and to study the hierarchy of fundus features that determine progression. METHODS: A group of 4953 subjects

  5. WWC Study Review Guide: Group Design Studies

    Science.gov (United States)

    What Works Clearinghouse, 2018

    2018-01-01

    Underlying all What Works Clearinghouse (WWC) products are WWC Study Review Guides, which are intended for use by WWC certified reviewers to assess studies against the WWC evidence standards. As part of an ongoing effort to increase transparency, promote collaboration, and encourage widespread use of the WWC standards, the Institute of Education…

  6. Studies of carbon--isotope fractionation. Annual progress report, December 1, 1974--November 30, 1975

    International Nuclear Information System (INIS)

    Ishida, T.

    1975-01-01

    The vapor pressure isotope effect of 13 C/ 12 C-substitution in CClF 3 was measured at temperatures between 169 0 and 206 0 K by means of cryogenic distillation. The 13 C/ 12 C-vapor pressure isotope effect in CHF 3 was also studied at temperatures between 161 0 and 205 0 K by a similar method. The construction of a cryostat has progressed as scheduled. The investigation of carbon isotope exchange equilibria between carbon dioxide and various carbamates dissolved in various organic solvents has continued. The five-stage system of Taylor-Ghate design was improved to shorten the transient time. A single stage apparatus was designed, built, and tested. These systems are used to measure the equilibrium constants and various phase equilibria involved in the carbon dioxide--carbamate system. The investigation of the explicit method of total isotope effect has made progress. A satisfactory approximation was found for the classical partition function of a Morse oscillator. The method gives a reasonable result at rho identical with 1 / 2 √(u/sub e//x/sub e/) greater than 1.5. The medium cluster approach was applied to isotopic methanes to investigate the effects of intermolecular distance and mutual orientations of molecules in the liquid upon vapor pressure isotope effect. It was found that all geometrical effects studied tend to vanish as the size of clusters is increased. Isotope effect in the zero-point energy shifts on condensation was calculated on the basis of London dispersion forces in liquid and a semi-empirical molecular orbital theory, and was favorably compared with experimental results

  7. Experimental and Theoretical Progress of Linear Collider Final Focus Design and ATF2 Facility

    CERN Document Server

    Seryi, Andrei; Zimmermann, Frank; Kubo, Kiyoshi; Kuroda, Shigeru; Okugi, Toshiyuki; Tauchi, Toshiaki; Terunuma, Nobuhiro; Urakawa, Junji; White, Glen; Woodley, Mark; Angal-Kalinin, Deepa

    2014-01-01

    In this brief overview we will reflect on the process of the design of the linear collider (LC) final focus (FF) optics, and will also describe the theoretical and experimental efforts on design and practical realisation of a prototype of the LC FF optics implemented in the ATF2 facility at KEK, Japan, presently being commissioned and operated.

  8. Progress in bipolar disorder drug design toward the development of novel therapeutic targets: a clinician's perspective.

    Science.gov (United States)

    Fornaro, Michele; Kardash, Lubna; Novello, Stefano; Fusco, Andrea; Anastasia, Annalisa; De Berardis, Domenico; Perna, Giampaolo; Carta, Mauro Giovanni

    2018-03-01

    Bipolar disorder (BD) is a considerable burden to the affected individual. The need for novel drug targets and improved drug design (DD) in BD is therefore clear. Areas covered: The following article provides a brief, narrative, clinician-oriented overview of the most promising novel pharmacological targets for BD along with a concise overview regarding the general DD process and the unmet needs relevant to BD. Expert opinion: A number of novel potential drug targets have been investigated. With the notable exception of the kynurenine pathway, available evidence is too scarce to highlight a definitive roadmap for forthcoming DD in BD. BD itself may present with different facets, as it is a polymorphic clinical spectrum. Therefore, promoting clinical-case stratification should be based on precision medicine, rather than on novel biological targets. Furthermore, the full release of raw study data to the scientific community and the development of uniform clinical trial standards (including more realistic outcomes) should be promoted to facilitate the DD process in BD.

  9. New progress of the study on uranium-gold association

    International Nuclear Information System (INIS)

    Feng Mingyue; Sun Zhifu

    1992-01-01

    Through the study on heavy minerals from the uraniferous granite-pegmatite it is found that nature gold is associated with uraninite, which provides the new information for the study on uranium-gold association and its metallogenesis

  10. New progress of the study on uranium-gold association

    Energy Technology Data Exchange (ETDEWEB)

    Mingyue, Feng; Zhifu, Sun [Beijing Research Inst. of Uranium Geology (China)

    1992-07-01

    Through the study on heavy minerals from the uraniferous granite-pegmatite it is found that nature gold is associated with uraninite, which provides the new information for the study on uranium-gold association and its metallogenesis.

  11. Progress and Challenges in the Design and Clinical Development of Antibodies for Cancer Therapy

    Directory of Open Access Journals (Sweden)

    Juan C. Almagro

    2018-01-01

    Full Text Available The remarkable progress in engineering and clinical development of therapeutic antibodies in the last 40 years, after the seminal work by Köhler and Milstein, has led to the approval by the United States Food and Drug Administration (FDA of 21 antibodies for cancer immunotherapy. We review here these approved antibodies, with emphasis on the methods used for their discovery, engineering, and optimization for therapeutic settings. These methods include antibody engineering via chimerization and humanization of non-human antibodies, as well as selection and further optimization of fully human antibodies isolated from human antibody phage-displayed libraries and immunization of transgenic mice capable of generating human antibodies. These technology platforms have progressively led to the development of therapeutic antibodies with higher human content and, thus, less immunogenicity. We also discuss the genetic engineering approaches that have allowed isotype switching and Fc modifications to modulate effector functions and bioavailability (half-life, which together with the technologies for engineering the Fv fragment, have been pivotal in generating more efficacious and better tolerated therapeutic antibodies to treat cancer.

  12. Progress in isotope hydrological study at Olak Lempit, Selangor

    International Nuclear Information System (INIS)

    Md Shahid Ayub

    2002-01-01

    This case study ia an on going project. Initial results from environmental isotopes and CFCs suggested short circuit to the groundwater flow. Removal of confining layer (if any) by mining activities could be the cause. It is also suggested the existence of saltwater / fresh water interface at the south-western fringe of the study area. This study is not yet conclusive. (Author)

  13. Some design aspects of transuranic field studies

    International Nuclear Information System (INIS)

    Gilbert, R.O.; Eberhardt, L.L.

    1977-01-01

    In this paper, we discuss some design aspects of transuranic field studies. Some of the principal steps in the design of such studies are given and illustrated using examples. This is followed by a review of sampling designs that have been used at nuclear detonation and safety-shot sites on the Nevada Test Site and elsewhere for estimating spatial pattern and total amounts in soil. Some design aspects of ecosystem-type transuranic studies for estimating total amounts as well as movement of transuranics between ecosystem components are also discussed. Acceptance sampling using either attributes or measurements is considered as a possible approach for deciding whether to clean up a contaminated site. Three general guidelines for the design of efficient transuranic studies are presented

  14. ACSYNT inner loop flight control design study

    Science.gov (United States)

    Bortins, Richard; Sorensen, John A.

    1993-01-01

    The NASA Ames Research Center developed the Aircraft Synthesis (ACSYNT) computer program to synthesize conceptual future aircraft designs and to evaluate critical performance metrics early in the design process before significant resources are committed and cost decisions made. ACSYNT uses steady-state performance metrics, such as aircraft range, payload, and fuel consumption, and static performance metrics, such as the control authority required for the takeoff rotation and for landing with an engine out, to evaluate conceptual aircraft designs. It can also optimize designs with respect to selected criteria and constraints. Many modern aircraft have stability provided by the flight control system rather than by the airframe. This may allow the aircraft designer to increase combat agility, or decrease trim drag, for increased range and payload. This strategy requires concurrent design of the airframe and the flight control system, making trade-offs of performance and dynamics during the earliest stages of design. ACSYNT presently lacks means to implement flight control system designs but research is being done to add methods for predicting rotational degrees of freedom and control effector performance. A software module to compute and analyze the dynamics of the aircraft and to compute feedback gains and analyze closed loop dynamics is required. The data gained from these analyses can then be fed back to the aircraft design process so that the effects of the flight control system and the airframe on aircraft performance can be included as design metrics. This report presents results of a feasibility study and the initial design work to add an inner loop flight control system (ILFCS) design capability to the stability and control module in ACSYNT. The overall objective is to provide a capability for concurrent design of the aircraft and its flight control system, and enable concept designers to improve performance by exploiting the interrelationships between

  15. GT-MHR COMMERCIALIZATION STUDY TECHNICAL PROGRESS AND COST MANAGEMENT REPORT FOR THE PERIOD AUGUST 1 THROUGH AUGUST 31, 2003

    International Nuclear Information System (INIS)

    Shenoy, A.S.

    2003-01-01

    OAK A271 GT-MHR COMERCIALiZATION STUDY TECHNICAL PROGRESS AND COST MANAGEMENT REPORT FOR THE PERIOD AUGUST 1 THROUGH AUGUST 31, 2003. In the process of fabricating the MHR-1 irradiation test capsule, Petten has advised that three thermocouples (out of 24) and the Self Powered Neutron detector were damaged during high temperature brazing with the upper capsule lid. Procurement of new TCs and SPN is in process but there will be a delay in the irradiation test of about nine weeks. Startup of the irradiation is now projected to be July or August 2004. In preparation for performing the nuclear design analysis activities required by the advanced fuel studies task, a complete 3-D nuclear design analysis is first being performed of the GT-MHR reference design. This will serve as the baseline for studies of the advanced fuel nuclear design performance

  16. Radioelement studies in the oceans. Progress report, April 15, 1981-April 14, 1982

    International Nuclear Information System (INIS)

    Bowen, V.T.; Livingston, H.D.; Cochran, J.K.; Sholkovitz, E.R.; Hess, M.R.

    1981-11-01

    Progress for the report period is reported under the following section headings: bibliographic summary - 1981; cruise reports and sampling activities; abstracts of reports published, submitted, or presented at meetings; and, brief summaries of work in progress. Research in progress includes the following studies: post-depositional chemistry of radionuclides: interstitial water composition and laboratory remobilizaton studies; thorium isotope studies in seawater; radionuclide measurements on samples from ocean weather ship MIKE, in the Norwegian Sea; counting technique optimization for Cs isotopes collected by chemisorption; Pu oxidation states in the Aleutian Trench water column; intercalibrations and standard materials; and radionuclides in deep water bathypelagic biota

  17. Design and Prototype Progress toward a Superconducting Crab Cavity Cryomodule for the APS

    International Nuclear Information System (INIS)

    Wang, Haipeng; Cheng, Guangfeng; Ciovati, Gianluigi; Henry, James; Kneisel, Peter; Rimmer, Robert; Slack, Gary; Turlington, Larry; waldschmidt, Geoff; Nassiri, Alireza

    2010-01-01

    A squashed, elliptical supercondconducting (SC) cavity with waveguide dampers on the beam pipes has currently been chosen as the baseline design for the Short Pulse X-ray (SPX) project at the Advanced Photon Source (APS). An alternate cavity design, with a waveguide damper located directly on the cavity cell for improved damping characteristics, has also been designed and cold-tested with promising results. In either case, eight cavities would be operated CW in a single cryomodule at 2K to produce an electron bunch chirp of 4MV at a frequency of 2.815 GHz. Detailed analysis of multipactoring (MP), Lorentz force detuning (LFD), and the thermal properties of the baseline design has led to an engineering specification of the basic parameters of the cryomodule.

  18. History, Progress and New Results in Synthetic Passive Element Design Employing CFTAs

    Directory of Open Access Journals (Sweden)

    Jaroslav Koton

    2015-03-01

    Full Text Available After the presentation of the Current Follower Transconductance Amplifier (CFTA active element, it has found a numerous application possibilities while designing linear and non-linear analog function blocks. This paper gives a short review of the CFTA and mainly focuses on the synthetic floating and grounded passive element design, which can also be electronically controllable. Except the design of synthetic inductors, also possible realizations of floating and grounded capacitors and resistors are described, where the value of these passive elements can be adjusted by means of active elements’ parameters. For the design of the corresponding circuit realizations, the Mason-Coates signal flow graph approach is used. The performance of some discussed synthetic elements is verified and  evaluated by Spice simulations on simple analog frequency filters.

  19. Progress in design and analysis of the net water cooled liquid breeder blanket

    International Nuclear Information System (INIS)

    Danner, W.; Rieger, M.; Verschuur, K.A.; Vieider, G.; Casini, G.; Chazalon, M.; Libin, B.; Farfaletti-Casali, F.; Piana, R.

    1987-01-01

    The NET liquid breeder blanket was subjected to a major design revision and integrated in the new NET-DN machine configuration. In this paper briefly the most essential design features are summarized and some results from thermohydraulics and 1D as well as 3D neutronics analyses are presented. It is concluded that the performance meets well the requirements of NET but that the concept needs substantial improvement if applied to a reactor

  20. Status of Progress Made Toward Preliminary Design Concepts for the Inventory in Select Media for DOE-Managed HLW/SNF

    Energy Technology Data Exchange (ETDEWEB)

    Matteo, Edward N. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Hardin, Ernest L. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Hadgu, Teklu [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Park, Heeho Daniel [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Rigali, Mark J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Jove-Colon, Carlos F. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2016-09-30

    As the title suggests, this report provides a summary of the status and progress for the Preliminary Design Concepts Work Package. Described herein are design concepts and thermal analysis for crystalline and salt host media. The report concludes that thermal management of defense waste, including the relatively small subset of high thermal output waste packages, is readily achievable. Another important conclusion pertains to engineering feasibility, and design concepts presented herein are based upon established and existing elements and/or designs. The multipack configuration options for the crystalline host media pose the greatest engineering challenges, as these designs involve large, heavy waste packages that pose specific challenges with respect to handling and emplacement. Defense-related Spent Nuclear Fuel (DSNF) presents issues for post-closure criticality control, and a key recommendation made herein relates to the need for special packaging design that includes neutron-absorbing material for the DSNF. Lastly, this report finds that the preliminary design options discussed are tenable for operational and post-closure safety, owing to the fact that these concepts have been derived from other published and well-studied repository designs.

  1. Progress in XRCS-Survey plant instrumentation and control design for ITER

    International Nuclear Information System (INIS)

    Varshney, Sanjeev; Jha, Shivakant; Simrock, Stefan; Barnsley, Robin; Martin, Vincent; Mishra, Sapna; Patil, Prabhakant; Patel, Shreyas; Kumar, Vinay

    2016-01-01

    Highlights: • An identification of the major process functions system compliant to Plant Control Design Handbook (PCDH) has been made for XRCS-Survey plant I&C. • I&C Functional Breakdown Structure (FBS) and Operation Procedure (OP) have been drafted using Enterprise architect (EA). • I&C architecture, interface with ITER networks and Plants, configuration of cubicles are discussed towards nine design review deliverables. - Abstract: A real time, plasma impurity survey system based on X-ray Crystal Spectroscopy (XRCS) has been designed for ITER and will be made available in the set of first plasma diagnostics for measuring impurity ion concentrations and their in-flux. For the purpose of developing a component level design of XRCS-Survey plant I&C system that is compliant to the rules and guidelines defined in the Plant Control Design Handbook (PCDH), firstly an identification of the major process functions has been made. The preliminary plant I&C Functional Breakdown Structure (FBS) and Operation Procedure (OP) have been drafted using a system engineering tool, Enterprise Architect (EA). Conceptual I&C architecture, interface with the ITER networks and other Plants have been discussed along with the basic configuration of I&C cubicles aiming towards nine I&C deliverables for the design review.

  2. Progress in XRCS-Survey plant instrumentation and control design for ITER

    Energy Technology Data Exchange (ETDEWEB)

    Varshney, Sanjeev, E-mail: sanjeev.varshney@iter-india.org [ITER-India, Institute for Plasma Research, Bhat, Gandhinagar, 382 428 (India); Jha, Shivakant [ITER-India, Institute for Plasma Research, Bhat, Gandhinagar, 382 428 (India); Simrock, Stefan; Barnsley, Robin; Martin, Vincent [ITER-Organization, Route de Vinon sur Verdon, CS 90 046, 13067 St. Paul-Lez-Durance, Cedex (France); Mishra, Sapna [ITER-India, Institute for Plasma Research, Bhat, Gandhinagar, 382 428 (India); Patil, Prabhakant [ITER-Organization, Route de Vinon sur Verdon, CS 90 046, 13067 St. Paul-Lez-Durance, Cedex (France); Patel, Shreyas; Kumar, Vinay [ITER-India, Institute for Plasma Research, Bhat, Gandhinagar, 382 428 (India)

    2016-11-15

    Highlights: • An identification of the major process functions system compliant to Plant Control Design Handbook (PCDH) has been made for XRCS-Survey plant I&C. • I&C Functional Breakdown Structure (FBS) and Operation Procedure (OP) have been drafted using Enterprise architect (EA). • I&C architecture, interface with ITER networks and Plants, configuration of cubicles are discussed towards nine design review deliverables. - Abstract: A real time, plasma impurity survey system based on X-ray Crystal Spectroscopy (XRCS) has been designed for ITER and will be made available in the set of first plasma diagnostics for measuring impurity ion concentrations and their in-flux. For the purpose of developing a component level design of XRCS-Survey plant I&C system that is compliant to the rules and guidelines defined in the Plant Control Design Handbook (PCDH), firstly an identification of the major process functions has been made. The preliminary plant I&C Functional Breakdown Structure (FBS) and Operation Procedure (OP) have been drafted using a system engineering tool, Enterprise Architect (EA). Conceptual I&C architecture, interface with the ITER networks and other Plants have been discussed along with the basic configuration of I&C cubicles aiming towards nine I&C deliverables for the design review.

  3. Structural Design Feasibility Study for the Global Climate Experiment

    Energy Technology Data Exchange (ETDEWEB)

    Lewin,K.F.; Nagy, J.

    2008-12-01

    Neon, Inc. is proposing to establish a Global Change Experiment (GCE) Facility to increase our understanding of how ecological systems differ in their vulnerability to changes in climate and other relevant global change drivers, as well as provide the mechanistic basis for forecasting ecological change in the future. The experimental design was initially envisioned to consist of two complementary components; (A) a multi-factor experiment manipulating CO{sub 2}, temperature and water availability and (B) a water balance experiment. As the design analysis and cost estimates progressed, it became clear that (1) the technical difficulties of obtaining tight temperature control and maintaining elevated atmospheric carbon dioxide levels within an enclosure were greater than had been expected and (2) the envisioned study would not fit into the expected budget envelope if this was done in a partially or completely enclosed structure. After discussions between NEON management, the GCE science team, and Keith Lewin, NEON, Inc. requested Keith Lewin to expand the scope of this design study to include open-field exposure systems. In order to develop the GCE design to the point where it can be presented within a proposal for funding, a feasibility study of climate manipulation structures must be conducted to determine design approaches and rough cost estimates, and to identify advantages and disadvantages of these approaches including the associated experimental artifacts. NEON, Inc requested this design study in order to develop concepts for the climate manipulation structures to support the NEON Global Climate Experiment. This study summarizes the design concepts considered for constructing and operating the GCE Facility and their associated construction, maintenance and operations costs. Comparisons and comments about experimental artifacts, construction challenges and operational uncertainties are provided to assist in selecting the final facility design. The overall goal

  4. Nuclear powered satellite studies. Annual progress report, July 1, 1977--June 30, 1978

    International Nuclear Information System (INIS)

    Kaplan, M.H.

    1978-06-01

    Progress achieved during the reporting period is reported. Discussions of several pertinent aspects are included, e.g., schedule, personnel, technology developments, and plans. The reporting period represents the second year of activities of a project which is designed to provide continuing support in the area of nuclear space power technology. Important results are summarized

  5. Mirror Advanced Reactor Study interim design report

    Energy Technology Data Exchange (ETDEWEB)

    1983-04-01

    The status of the design of a tenth-of-a-kind commercial tandem-mirror fusion reactor is described at the midpoint of a two-year study. When completed, the design is to serve as a strategic goal for the mirror fusion program. The main objectives of the Mirror Advanced Reactor Study (MARS) are: (1) to design an attractive tandem-mirror fusion reactor producing electricity and synfuels (in alternate versions), (2) to identify key development and technology needs, and (3) to exploit the potential of fusion for safety, low activation, and simple disposal of radioactive waste. In the first year we have emphasized physics and engineering of the central cell and physics of the end cell. Design optimization and trade studies are continuing, and we expect additional modifications in the end cells to further improve the performance of the final design.

  6. Cryostat design case studies, principles and engineering

    CERN Document Server

    2016-01-01

    This book enables the reader to learn the fundamental and applied aspects of practical cryostat design by examining previous design choices and resulting cryostat performance. Through a series of extended case studies the book presents an overview of existing cryostat design covering a wide range of cryostat types and applications, including the magnet cryostats that comprise the majority of the Large Hadron Collider at CERN, space-borne cryostats containing sensors operating below 1 K, and large cryogenic liquid storage vessels. It starts with an introductory section on the principles of cryostat design including practical data and equations. This section is followed by a series of case studies on existing cryostats, describing the specific requirements of the cryostat, the challenges involved and the design choices made along with the resulting performance of the cryostat. The cryostat examples used in the studies are chosen to cover a broad range of cryostat applications and the authors of each case are ...

  7. Mirror Advanced Reactor Study interim design report

    International Nuclear Information System (INIS)

    1983-04-01

    The status of the design of a tenth-of-a-kind commercial tandem-mirror fusion reactor is described at the midpoint of a two-year study. When completed, the design is to serve as a strategic goal for the mirror fusion program. The main objectives of the Mirror Advanced Reactor Study (MARS) are: (1) to design an attractive tandem-mirror fusion reactor producing electricity and synfuels (in alternate versions), (2) to identify key development and technology needs, and (3) to exploit the potential of fusion for safety, low activation, and simple disposal of radioactive waste. In the first year we have emphasized physics and engineering of the central cell and physics of the end cell. Design optimization and trade studies are continuing, and we expect additional modifications in the end cells to further improve the performance of the final design

  8. FED/INTOR reactor design studies

    International Nuclear Information System (INIS)

    Brown, T.G.; Cramer, B.A.; Davisson, J.P.; Kunselman, M.H.; Reiersen, W.T.; Sager, P.H.; Strickler, D.J.

    1982-03-01

    Upon completing the design studies identified in this report, an overall assessment of the design options is made that will form the bases to define the configuration of the next major Tokamak device. The TF coil size will be defined, along with the vacuum boundary, the PF coil arrangement, and the torus configuration. After the configuration is established, an overall performance and cost re-assessment should be made to finally trade off device performance with machine capital and operating costs to establish a reactor design point for a given set of design requirements

  9. Nuclear-Powered GPS Spacecraft Design Study

    Energy Technology Data Exchange (ETDEWEB)

    Raab, Bernard

    1977-05-01

    This is the final report of a study to investigate the potential benefits of a nuclear (radioisotope) - powered satellite for advanced phases of the Global Positioning System (GPS) program. The critical parameters were: power to user; mean mission duration; orbital predictability; thermal control of on-board frequency standards; and vulnerability. The reference design approach is described, and input data are given for two power systems that are under development: an organic Rankine system and a Brayton cycle system. Reference design details are provided and structural design and analysis are discussed, as well as thermal design and analysis. A higher altitude version is also considered.

  10. Flight Path Recovery System (FPRS) design study

    Energy Technology Data Exchange (ETDEWEB)

    1978-09-01

    The study contained herein presents a design for a Flight Path Recovery System (FPPS) for use in the NURE Program which will be more accurate than systems presently used, provide position location data in digital form suitable for automatic data processing, and provide for flight path recovery in a more economic and operationally suitable manner. The design is based upon the use of presently available hardware and technoloy, and presents little, it any, development risk. In addition, a Flight Test Plan designed to test the FPRS design concept is presented.

  11. Flight Path Recovery System (FPRS) design study

    International Nuclear Information System (INIS)

    1978-09-01

    The study contained herein presents a design for a Flight Path Recovery System (FPPS) for use in the NURE Program which will be more accurate than systems presently used, provide position location data in digital form suitable for automatic data processing, and provide for flight path recovery in a more economic and operationally suitable manner. The design is based upon the use of presently available hardware and technoloy, and presents little, it any, development risk. In addition, a Flight Test Plan designed to test the FPRS design concept is presented

  12. Radical Designs: The Emergence of the Progressive Editorial in the Nineteenth-Century Press

    Directory of Open Access Journals (Sweden)

    David Dowling

    2017-01-01

    Full Text Available This article traces the transformation of the newspaper editorial in the nineteenth century from a partisan platform narrowly focused on contemporary politics into a broader more inclusive genre engaging progressive cultural reform with a literary bent. After 1814, the newspaper editorial spread its wings and soared with lofty poetic rhetoric and increasingly metaphorical language. Editors frequently broke into verse in their columns, inspired by the powerful presence of poetry and oratory in antebellum culture. A key figure at the heart of that oratorical and poetic culture was Ralph Waldo Emerson, who held a prominent position in print culture through books and newspaper reports of his speaking engagements. Horace Greeley, Karl Marx, Fanny Fern, Margaret Fuller, and Harriet Martineau form the subjects of this study because they reflect Emerson’s radical liberal influence on the emergence of the progressive editorial, particularly through literary stylistics blending poetic and philosophical rhetoric. These figures represent a diverse transatlantic mix of revolutionary and feminist columnists from the weekly and daily press who extended Emerson’s purview, especially his critiques of capitalism and institutional corruption. This approach diversifies previous understandings of the evolution of the editorial reflected in Allen Nevins’ American Press Opinion (1928, which exclusively focuses on American political editorials written by men. The more recent 1997 anthology of historical editorials by Sloan, Wray, and Sloan also excludes women and transnational journalism. The commercial press liberated the news industry from the partisan press, providing new opportunities for Emerson protégés such as Fuller to capitalize on her literary prowess, transcendentalist sensibility, and female perspective to offer some of the most politically powerful and socially efficacious writing published in the New-York Tribune. These editorialists reached

  13. Combined thermodynamic study of nickel-base alloys. Progress report

    International Nuclear Information System (INIS)

    Brooks, C.R.; Meschter, P.J.

    1981-01-01

    Achievements during this period are the following: (1) initiation of a high-temperature study of the Ni-Ta system using the galvanic cell technique, (2) emf study of high-temperature thermodynamics in the Ni-Mo system, (3) measured heat capacity data on ordered and disordered Ni 4 Mo, (4) heat capacities of Ni and disordered Ni 3 Fe, and (5) computer correlation of thermodynamic and phase diagram data in binary Ni-base alloys

  14. Design of steel energy-absorbing restrainers and their incorporation into nuclear power plants for enhanced safety. Progress report

    International Nuclear Information System (INIS)

    1980-03-01

    This program for the development of steel energy-absorbing restrainers originated as a five year multi-institutional, interdisciplinary program. The resources of the University of California, Berkeley (UCB), the Earthquake Engineering Research Center, Richmond (EERC), Massachusetts Institute of Technology (MIT), and Battelle Pacific Northwestern Laboratories (BPNL) are utilized as well as advisors from industry, the utilities and the US Nuclear Regulatory Commission. The present progress report involves the areas of experimental testing on the shaking table at the EERC, restrainer device design and testing, structural analyses and materials testing

  15. Stable isotope studies: Progress report, March 1985--August 1987

    International Nuclear Information System (INIS)

    Ishida, Takanobu.

    1987-01-01

    Studies have been carried out in the following areas: Stable Isotope Fractionation (1) Effects of chemical poisons and surface modifiers on polycrystalline platinum electrode surfaces have been investigated with a goal to develop a new form of heterogeneous catalyst for the hydrogen isotope exchange between dihydrogen and water. (2) A new nitrogen-15 fractionation process has been developed, based on the isotope exchange between liquid N 2 O 3 -N 2 O 4 mixture and their vapor phase at a subambient temperature and a raised pressure. (3) A closed chemical recycle process has been developed for use in connection with the refluxer in the Nitrox-type nitrogen-15 plant. Isotope Effects (1) The vapor pressure isotope effect (VPIE) study of liquid fluoromethanes have been completed. (2) The VPIE study of solid and liquid ammonia has been completed. (3) A theoretical foundation of the additivity for the vibrational zero-point energy (ZPE) has been developed. Studies of Liquid Ammonia. With an aim to study intermolecular interaction (and the inversion phenomenon, in particular) in liquid ammonia, and to further investigate various ammonia solutions, a molecular dynamics (MD) study has been initiated. An MD program has been completed, and force field functions have been developed for an ensemble of non-rigid ammonia molecules. 107 refs., 41 figs., 10 tabs

  16. Optimal design and routing of power lines; ecological, technical and economic perspectives (OPTIPOL). Progress report 2009

    Energy Technology Data Exchange (ETDEWEB)

    Bevanger, K.; Bartzke, G.; Broeseth, H.; Gjershaug, J.O.; Hanssen, F.; Jacobsen, K.-O.; Kvaloey, P.; May, R.; Nygaard, T.; Pedersen, H.C.; Reitan, O.; Refsnaes, S.; Stokke, S.; Vang, R.

    2009-12-15

    From 2009 inclusive, NINA has received economic support for research on power lines and wildlife from the Norwegian Research Council (NFR) through the RENERGI Programme. The project is named 'Optimal design and routing of power lines; ecological, technical and economic perspectives' (OPTIPOL). It is scheduled for 5 years (2009-1013) and is part of the activities within CEDREN, i.e. the Centre for environmental design of renewable energy (cf. http://www.cedren.no). With a grid close to 200 000 km overhead power-lines, the associated rights-of-way (ROW) affect huge land areas in Norway. The overall goal is to develop predict-ing tools for optimal routing of power lines from an environmental perspective and assess technical and economic solutions to minimize conflicts with wildlife and habitat conservation. Thus, the OPTIPOL rationale is based on the belief that the negative effects of electricity transmission and distribution can be reduced with respect to birds and mammals. OPTIPOL has several ambitious objectives, and is divided into sub-projects and specific tasks. From the first of November a PhD-student became part of the project, a position that will be held for 4 years. The main objective of the PhD-activities will be to assess how and why different wildlife species use deforested areas below power lines, evaluate possible positive and negative effects of power-line ROWs, and assess the possibilities for quality improvement. Another part of the project is dedicated the effects of linear structures on movement patterns and distribution in the landscape in native deer species. Here we will examine how different spatial scales influence the processes that guide movement patterns, and responses to linear structures. Another focus will be small game species, with mountain hare, capercaillie, black grouse and hazel grouse as model species. The main objective will be to assess the impact of transforming ROW habitats into attractive small-game foraging

  17. Least-cost groundwater remediation design using uncertain hydrogeological information. 1998 annual progress report

    International Nuclear Information System (INIS)

    Pinder, G.F.

    1998-01-01

    'The objective of the project is to formulate, test, and evaluate a new approach to the least-cost design of groundwater contamination containment and decontamination systems. The proposed methodology employs robust optimization, the outer-approximation method of non-linear programming, and groundwater flow and transport modeling to find the most cost-effective pump-and-treat design possible given the physical parameters describing the groundwater reservoir are known with uncertainty. The result is a methodology that will provide the least-cost groundwater remediation design possible given a specified set of design objectives and physical and sociological constraints. As of the end of the first year of this 3-year project the author has developed and tested the concept of robust optimization within the framework of least-cost groundwater-contamination-containment design. The outer-approximation method has been employed in this context for the relatively simple linear-constraint case associated with the containment problem. In an effort to enhance the efficiency and applicability of this methodology, a new strategy for selecting the various realizations arising out of the Monte-Carlo underpinnings of the robust-optimization technique has been developed and tested. Based upon observations arising out of this work a yet more promising approach has been discovered. The theoretical foundation for this most recent approach has been, and continues to be, the primary focus of the research.'

  18. A longitudinal study of motor, oculomotor and cognitive function in progressive supranuclear palsy.

    Directory of Open Access Journals (Sweden)

    Boyd C P Ghosh

    Full Text Available We studied the annual change in measures of motor, oculomotor and cognitive function in progressive supranuclear palsy. This had twin objectives, to assess the potential for clinical parameters to monitor disease progression in clinical trials and to illuminate the progression of pathophysiology.Twenty three patients with progressive supranuclear palsy (Richardson's syndrome were compared to 22 matched controls at baseline and 16 of these patients compared at baseline and one year using: the progressive supranuclear palsy rating scale; the unified Parkinson's disease rating scale; the revised Addenbrooke's cognitive examination; the frontal assessment battery; the cubes section of the visual object and space perception battery; the Hayling and Brixton executive tests; and saccadic latencies.Patients were significantly impaired in all domains at baseline. However, cognitive performance was maintained over a year on the majority of tests. The unified Parkinson's disease rating scale, saccadic latency and progressive supranuclear palsy rating scale deteriorated over a year, with the latter showing the largest change. Power estimates indicate that using the progressive supranuclear palsy rating scale as an outcome measure in a clinical trial would require 45 patients per arm, to identify a 50% reduction in rate of decline with 80% power.Motor, oculomotor and cognitive domains deteriorate at different rates in progressive supranuclear palsy. This may be due to differential degeneration of their respective cortical-subcortical circuits, and has major implications for the selection of outcome measures in clinical trials due to wide variation in sensitivity to annual rates of decline.

  19. Conceptual design study of fusion experimental reactor (FY86 FER)

    International Nuclear Information System (INIS)

    Seki, Yasushi; Iida, Hiromasa; Honda, Tsutomu.

    1987-08-01

    This report describes the study on safety for FER(Fusion Experimental Reactor) which has been designed as a next step machine to the JT-60. Though the final purpose of this study is to have an image of design base accident, maximum credible accident and to assess their risk or probability, etc., as FER plant system, the emphasis of this years study is placed on fuel-gas circulation system where the tritium inventory is maximum. This report consists of two chapters. The first chapter of this report summaries the FER system and describes FMEA(Failure Mode and Effect Analysis) and related accident progression sequence for FER plant system as a whole. The second chapter of this report is focused on fuel-gas circulation system including the purification, isotope separation system and storage system. Here, probability of risk is assessed by the probabilistic risk analysis (PRA) procedure based on FMEA, ETA and FTA. (author)

  20. Progress in waste package and engineered barrier system performance assessment and design

    International Nuclear Information System (INIS)

    Van Luik, A.; Stahl, D.; Harrison, D.

    1993-01-01

    As part of the U.S. Department of Energy's evaluation of site suitability for a potential high-level radioactive waste repository, long-term interactions between the engineered barrier system and the site must be determined. This requires a waste-package/engineered-system design, a description of the environment around the emplacement zone, and models that simulate operative processes describing these engineered/natural systems interactions. Candidate designs are being evaluated, including a more robust, multi-barrier waste package, and a drift emplacement mode. Tools for evaluating designs, and emplacement mode are the currently available waste-package/engineered-system performance assessment codes development for the project. For assessments that support site suitability, environmental impact, or licensing decisions, more capable codes are needed. Code capability requirements are being written, and existing codes are to be evaluated against those requirements. Recommendations are being made to focus waste-packaging/engineered-system code-development

  1. Biophysical studies related to energy generation: Progress report

    International Nuclear Information System (INIS)

    Green, A.E.S.

    1988-01-01

    This report covers work subsequent to our previous report of December 24, 1986. At that time we were groping to find relationships between vibrational and rotational electron impact cross sections in the vapor and liquid phases of water. Having reached an impass within the radiological literature, we drew upon the atmospheric, oceanographic and flame radiation literatures. Here a much broader body of excitation energy and intensity data related to the vibrational and rotational excitation of water in the vapor phases and liquid phases enabled us to identify certain ''big bands'' of H 2 O. These bands account for the major infrared absorption features observed in atmospheric transmission studies as well as important spectral radiation features observed in hydrocarbon combustion. Related liquid phase-gas phase involvement also entered our work on co-combustion of biomass and waste, and natural gas in studies directed toward contributing to the solution of national energy-environmental and economic problems. Attachments to this report include our published works, submitted works, and in complete studies related to radiological, atmospheric, and combustion studies which encompass biophysical studies related to energy generation and which have a common thread involving water in liquid and vapor form. These works are tied together in this brief report, along with some comments on trends in science and technology which they might illustrate

  2. LSST summit facility construction progress report: reacting to design refinements and field conditions

    Science.gov (United States)

    Barr, Jeffrey D.; Gressler, William; Sebag, Jacques; Seriche, Jaime; Serrano, Eduardo

    2016-07-01

    The civil work, site infrastructure and buildings for the summit facility of the Large Synoptic Survey Telescope (LSST) are among the first major elements that need to be designed, bid and constructed to support the subsequent integration of the dome, telescope, optics, camera and supporting systems. As the contracts for those other major subsystems now move forward under the management of the LSST Telescope and Site (T and S) team, there has been inevitable and beneficial evolution in their designs, which has resulted in significant modifications to the facility and infrastructure. The earliest design requirements for the LSST summit facility were first documented in 2005, its contracted full design was initiated in 2010, and construction began in January, 2015. During that entire development period, and extending now roughly halfway through construction, there continue to be necessary modifications to the facility design resulting from the refinement of interfaces to other major elements of the LSST project and now, during construction, due to unanticipated field conditions. Changes from evolving interfaces have principally involved the telescope mount, the dome and mirror handling/coating facilities which have included significant variations in mass, dimensions, heat loads and anchorage conditions. Modifications related to field conditions have included specifying and testing alternative methods of excavation and contending with the lack of competent rock substrate where it was predicted to be. While these and other necessary changes are somewhat specific to the LSST project and site, they also exemplify inherent challenges related to the typical timeline for the design and construction of astronomical observatory support facilities relative to the overall development of the project.

  3. The FCC-ee study: Progress and challenges

    OpenAIRE

    Koratzinos, Michael; Aumon, Sandra; Bogomyagkov, Anton; Boscolo, Manuela; Cook, Charlie; Doblhammer, Andreas; Härer, Bastian; Tomás, Rogelio; Levichev, Evgeny; Medina Medrano, Luis; Shatilov, Dmitry; Wienands, Ulrich; Zimmermann, Frank

    2015-01-01

    The FCC (Future Circular Collider) study represents a vision for the next large project in high energy physics, comprising an 80-100 km tunnel that can house a future 100 TeV hadron collider. The study also includes a high luminosity e+e- collider operating in the centre-of-mass energy range of 90-350 GeV as a possible intermediate step, the FCC-ee. The FCC-ee aims at definitive electro-weak precision measurements of the Z, W, H and top particles, and search for rare phenomena. Although FCC-e...

  4. Studies in iodine metabolism: Progress report, July 1968-July 1969

    Energy Technology Data Exchange (ETDEWEB)

    Van Middlesworth, L.

    1987-01-01

    This document describes research on iodine metabolism conducted at the University of Tennessee, Memphis between July 1968 and July 1969. The author and his research team prepared autoradiographs of rat thyroids from individuals exposed to Iodine 125 in utero. Additional studies were conducted to determine the effect on hypothalamic lesions on iodide metabolism in rats; to evaluate an iodide-specific electrode for measuring iodide levels in blood or urine; and to study the amount of thyroxine absorption from the intestine. An analysis of bovine and sheep thyroids from eight locations provided additional information on global fallout levels. 21 figs., 2 tabs.

  5. High-Temperature Air-Cooled Power Electronics Thermal Design: Annual Progress Report

    Energy Technology Data Exchange (ETDEWEB)

    Waye, Scot [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2016-08-01

    Power electronics that use high-temperature devices pose a challenge for thermal management. With the devices running at higher temperatures and having a smaller footprint, the heat fluxes increase from previous power electronic designs. This project overview presents an approach to examine and design thermal management strategies through cooling technologies to keep devices within temperature limits, dissipate the heat generated by the devices and protect electrical interconnects and other components for inverter, converter, and charger applications. This analysis, validation, and demonstration intends to take a multi-scale approach over the device, module, and system levels to reduce size, weight, and cost.

  6. The Heritability of Insomnia Progression during Childhood/Adolescence: Results from a Longitudinal Twin Study

    Science.gov (United States)

    Barclay, Nicola L.; Gehrman, Philip R.; Gregory, Alice M.; Eaves, Lindon J.; Silberg, Judy L.

    2015-01-01

    Study Objectives: To determine prevalence and heritability of insomnia during middle/late childhood and adolescence; examine longitudinal associations in insomnia over time; and assess the extent to which genetic and environmental factors on insomnia remain stable, or whether new factors come into play, across this developmental period. Design: Longitudinal twin study. Setting: Academic medical center. Patients or Participants: There were 739 complete monozygotic twin pairs (52%) and 672 complete dizygotic twin pairs (48%) initially enrolled and were followed up at three additional time points (waves). Mode ages at each wave were 8, 10, 14, and 15 y (ages ranged from 8–18 y). Interventions: None. Measurements and Results: Clinical ratings of insomnia symptoms were assessed using the Child and Adolescent Psychiatric Assessment (CAPA) by trained clinicians, and rated according to Diagnostic and Statistical Manual of Mental Disorders, 3rd Edition—Revised criteria for presence of “clinically significant insomnia,” over four sequential waves. Insomnia symptoms were prevalent but significantly decreased across the four waves (ranging from 16.6% to 31.2%). “Clinically significant insomnia” was moderately heritable at all waves (h2 range = 14% to 38%), and the remaining source of variance was the nonshared environment. Multivariate models indicated that genetic influences at wave 1 contributed to insomnia at all subsequent waves, and that new genetic influences came into play at wave 2, which further contributed to stability of symptoms. Nonshared environmental influences were time-specific. Conclusion: Insomnia is prevalent in childhood and adolescence, and is moderately heritable. The progression of insomnia across this developmental time period is influenced by stable as well as new genetic factors that come into play at wave 2 (modal age 10 y). Molecular genetic studies should now identify genes related to insomnia progression during childhood and

  7. Progress in the Study of Coastal Storm Deposits

    Science.gov (United States)

    Xiong, Haixian; Huang, Guangqing; Fu, Shuqing; Qian, Peng

    2018-05-01

    Numerous studies have been carried out to identify storm deposits and decipher storm-induced sedimentary processes in coastal and shallow-marine areas. This study aims to provide an in-depth review on the study of coastal storm deposits from the following five aspects. 1) The formation of storm deposits is a function of hydrodynamic and sedimentary processes under the constraints of local geological and ecological factors. Many questions remain to demonstrate the genetic links between storm-related processes and a variety of resulting deposits such as overwash deposits, underwater deposits and hummocky cross-stratification (HCS). Future research into the formation of storm deposits should combine flume experiments, field observations and numerical simulations, and make full use of sediment source tracing methods. 2) Recently there has been rapid growth in the number of studies utilizing sediment provenance analysis to investigate the source of storm deposits. The development of source tracing techniques, such as mineral composition, magnetic susceptibility, microfossil and geochemical property, has allowed for better understanding of the depositional processes and environmental changes associated with coastal storms. 3) The role of extreme storms in the sedimentation of low-lying coastal wetlands with diverse ecosystem services has also drawn a great deal of attention. Many investigations have attempted to quantify widespread land loss, vertical marsh sediment accumulation and wetland elevation change induced by major hurricanes. 4) Paleostorm reconstructions based on storm sedimentary proxies have shown many advantages over the instrumental records and historic documents as they allow for the reconstruction of storm activities on millennial or longer time scales. Storm deposits having been used to establish proxies mainly include beach ridges and shelly cheniers, coral reefs, estuary-deltaic storm sequences and overwash deposits. Particularly over the past few

  8. Studying Design Engineers Use Of Information Systems

    DEFF Research Database (Denmark)

    Restrepo-Giraldo, John Dairo

    2006-01-01

    Studying information usage by design engineers involves considering technical, social, cognitive and volitional factors. This makes it challenging, especially for researchers without a cognitive psychology background. This paper presents a summary of key findings in researching information use...

  9. Optimization of flowable concrete for structural design : Progress report of fib task group 8.8

    NARCIS (Netherlands)

    Grunewald, S.; Ferrara, L.; Dehn, F.

    2014-01-01

    With the tendency to apply concrete with a higher workability and the use of new concrete components more options are available to design concrete. New concrete types like self-compacting concrete (SCC), ultra-high performance fibre reinforced concrete (UHPFRC) and high performance fibre reinforced

  10. Introduction. Progress in Earth science and climate studies.

    Science.gov (United States)

    Thompson, J Michael T

    2008-12-28

    In this introductory paper, I review the 'visions of the future' articles prepared by top young scientists for the second of the two Christmas 2008 Triennial Issues of Phil. Trans. R. Soc.A, devoted respectively to astronomy and Earth science. Topics covered in the Earth science issue include: trace gases in the atmosphere; dynamics of the Antarctic circumpolar current; a study of the boundary between the Earth's rocky mantle and its iron core; and two studies of volcanoes and their plumes. A final section devoted to ecology and climate covers: the mathematical modelling of plant-soil interactions; the effects of the boreal forests on the Earth's climate; the role of the past palaeoclimate in testing and calibrating today's numerical climate models; and the evaluation of these models including the quantification of their uncertainties.

  11. Radioactivity studies. Progress report, April 30, 1984-June 1, 1985

    International Nuclear Information System (INIS)

    Cohen, N.

    1985-06-01

    This report includes information pertaining to metabolic studies of neptunium and protactinium in the adult baboon. Recent investigations have provided additional data on the uptake, distribution, retention and excretion of Np-237, Np-239 and Pa-233 in baboons following single intravenous and gavage administrations. Data is also presented on the gastrointestinal absorption of isotopes of uranium, neptunium and plutonium in individual baboons after receiving multiple gavage administrations at selected time intervals and nutritional states. The gastrointestinal (GI) absorption (f 1 values) and retention factors have been calculated for each of these nuclides. We have begun metabolic studies on the adult tamarin (Saquinis labiatus). Data are presented in this report on the preliminary results of the metabolism of Np-239 bicarbonate intravenously injected into three females and one male tamarin. These data are discussed in comparison with similar results obtained with our baboons and with other species. 28 refs., 20 figs., 14 tabs

  12. Stable isotope studies. Progress report, March 1, 1985-October 1985

    International Nuclear Information System (INIS)

    Ishida, T.

    1985-01-01

    The studies of last year have been continued in three experimental and two theoretical areas. A closed recycle process for SO 2 /H 2 SO 4 has been developed. The phase ratios of the isotopic reduced partition function ratios for solid and liquid 14 NH 3 / 14 ND 3 and 14 NH 3 / 15 NH 3 and for 12 CH 2 F 2 / 12 CD 2 F 2 and 12 CH 2 F 2 / 13 CH 2 F 2 have been obtained from differential vapor pressure data, and F matrices for each phase of each chemical species have been calculated. A concept of combining chemically modified electrodes and supported catalysts has been investigated. Results of ab initio MO calculations on various clusters of methylene fluoride are compared to those on the clusters of methyl fluoride and fluoroform. An MO study on clusters of ammonia molecules has been started. 29 refs., 3 figs., 10 tabs

  13. Recent progress in the study of fission reaction

    International Nuclear Information System (INIS)

    Blons, J.; Paya, D.; Signarbieux, C.

    1977-01-01

    The different steps of the fission phenomenon are briefly recalled before a more detailed study of the static aspect of the fission barrier crossing. The experiments performed at Saclay during the last few years seem to confirm the calculations according to which a triple humped fission barrier is expected for the thorium isotopes. The last part deals with some dynamical aspects of the process. Recent results are presented which tend to prove that the nuclear viscosity decreases when the excitation energy increases [fr

  14. Radiological study of Mururoa and Fangataufa : progress report

    International Nuclear Information System (INIS)

    Anon.

    1997-01-01

    The IAEA-coordinated study of the radiological situation at the Atolls of Mururoa and Fangataufa arose from a request from the French government for an independent review. The request was considered at an informal technical consultation meeting between scientists from several Member States and representatives of intergovernmental organizations at the Agency in Vienna in January 1996. The meeting discussed the objectives of the Study and matters that should be included in its terms of reference and considered the Task and Working Group structure needed to carry out the assessments. The Task and Working Groups have nearly completed their work. Drafts of the Working Groups' technical reports were considered at a coordination and review meeting of Task and Working Group Chairmen and Agency Project Management Office representatives on 17-19 September 1997. Final drafts of the technical reports of the Task and Working Groups are due to be completed before the end of November 1997, and the penultimate draft of the Study report is to be circulated to International Advisory Committee members in December. (author)

  15. Radiation-damage studies for fusion reactors. Progress report

    International Nuclear Information System (INIS)

    Kulcinski, G.L.; Dodd, R.A.

    1983-01-01

    FY 1983 has been a very productive year with respect to obtaining results and educating students in the field of Fusion Materials. We have analyzed the results of 14 MeV irradiated copper and have correlated the information with previous work done at HEDL. The 750 keV light ion accelerator has been used to preimplant samples with He as well as to study blistering in nickel. A collaborative effort with ORNL was completed on helium-irradiated Cu-Ni alloys. The effects of injected interstitials on void nucleation were studied and a theory developed to explain some past discrepancies in ion irradiated specimens. Initial ion irradiations have been performed on 316 SS and HT-9 alloys. New techniques for plating type 316 stainless steel, ferritic steels and aluminum have been developed as well as intense beams of Fe, Ti and Al for ion bombardment studies. Two new electron microscopy facilities have been installed; a JELCO-200CX with EDX capabilities a high resolution Vacuum Generator HB501 for very precise microchemical analysis

  16. [Studies of heavy-ion induced reactions]: Annual progress report

    International Nuclear Information System (INIS)

    Mignerey, A.C.

    1986-10-01

    An experiment was performed at the Lawrence Berkeley Laboratory Bevalac, extending previous studies using inverse reactions to 50 MeV/u 139 La incident on targets of C and Al. Studies of excitation energy division in lower energy division in lower energy heavy-ion reactions were furthered using kinematic coincidences to measure the excitation energies of primary products in the Fe + Ho reaction at 12 MeV/u. These results will provide important systematics for comparisons with previous measurements at 9 MeV/u on the same system and at 15 MeV/u on the Fe + Fe and Fe + U systems. Also studied were different aspects of 15 MeV/u Fe-induced reactions, with experiments performed at the Oak Ridge HHIRF. The first three contributions of this report constitute a major portion of the results from this research. Finally, at the Lawrence Berkeley Laboratory Bevalac a large detector array for coincident detection of fragmentation products in heavy-ion collisions below 100 MeV/u is being built. A list of publications, personnel, and activities is provided

  17. Radioactivity studies. Progress report, January 1-December 31, 1982

    International Nuclear Information System (INIS)

    Cohen, N.

    1983-06-01

    During the last year, the research program in actinide biokinetics in nonhuman primates has been expanded to include preliminary studies of the element neptunium. Recently, Np-237, which is known to be present in high-level nuclear reactor waste, has received increased attention as a potential long-range hazard to man. In addition to the neptunium studies, the metabolism of protactinium-233, the daughter of Np-237, has been investigated. Although characterization of Pa-233 metabolism was originally conducted in order to correct for Pa-233 interference during in vivo and in vitro gamma spectrometry of Np-237, several other considerations indicated that Pa might be of radiological concern itself and should thereby warrant further investigation. Due to the limited amount of data in the literature defining the biokinetics of both neptunium and protactinium, metabolis studies of these nuclides are now being conducted in adult female baboons in a manner similar to that which has been successfully performed at this laboratory for Am-241 and Cm-243,244. Procedures routinely performed include external whole-body counting, excreta collection (separation and measurement), blood sampling, biopsies of liver and bone, and complete tissue and organ analysis after sacrifice

  18. Study of high energy physics underground. Technical progress report

    International Nuclear Information System (INIS)

    1984-10-01

    The Homestake Large Area Scintillation Detector consists of 140 tons of liquid scintillator in a hollow 8 m x 8 m x 16 m box surrounding the Brookhaven 37 Cl solar neutrino detector. The experiment is located at a depth of 4850 ft. (4200 m.w.e.) in the Homestake Gold Mine. Half of the detector is currently running; the full detector will be taking data by the fall of 1984. An extensive air shower array is also currently under construction on the earth's surface above the underground detector, consisting of 100 scintillators, each 3 m 2 , covering approximately 0.8 km 2 ; the first portion of the surface array will also be providing data this fall. Together, the new Homestake detectors will be used to search for slow, massive magnetic monopoles; study the zenith angle distribution of neutrino-induced muons; search for neutrino bursts from the gravitational collapse of massive stars; measure the multiplicity and transverse momentum distributions of cosmic ray muons; and study the composition of the primary cosmic rays. The underground device and its capabilities as a monopole detector are described, followed by the surface array and the cosmic ray studies

  19. Progress in resolving open design issues from the ODR. Report by the Director. ITER technical advisory committee meeting, 25-27 June 2000, St. Petersburg

    International Nuclear Information System (INIS)

    2000-01-01

    This report presents progress in resolving open design issues from the ITER-FEAT Outline Design Report and is not repeating the ODR information but concentrates on the specific issues and the progress towards their resolution. It includes some aspects of the Physics analysis (inductive operation scenario and sensitivity analysis, ion heating, possibility of high Q and ignition operation, divertor physics), Magnets (TF coil loads, inductive flux generation, conductor design issues), Vessel/in Vessel (manifolding of blanket coolant, vacuum vessel design development, design implications of divertor material choice), Buildings and Plant services, Operation and Safety

  20. Study of transitional nuclei at TRISTAN. Progress report

    International Nuclear Information System (INIS)

    Petry, R.F.

    1983-01-01

    During the past calendar year the Oklahoma group has participated in decay studies on the following nuclides: 99 Rb, 99 Sr, 101 Y, and 100 Y. The resulting information on the structure of these nuclides has defined band structure for the first time in the odd-A nuclei in this region. The principal investigator also participated in a measurement of the g-factor of an excited state in 97 Zr and two attempts to measure the quadrupole moment of the same state. Details of these and other activities are given

  1. UK Nuclear Science Forum. Progress report: Data studies during 2000

    International Nuclear Information System (INIS)

    Nichols, A.L.

    2001-06-01

    The UK Nuclear Science Forum (UKNSF) now meets once per year to discuss issues of direct relevance to forum members, and to review nuclear data for application in the UK nuclear industry. Links are also maintained through the year, mainly through e-mail and the normal postal system. Work of immediate interest includes the measurement and evaluation of decay data (e.g., half-lives and gamma-ray emission probabilities), fission yields and thermal neutron cross sections; all known UK studies in 2000 are summarised in this document. Specific applications and international links of relevance in the field of nuclear data are also described

  2. Recent Progress in Design of Biomass-Derived Hard Carbons for Sodium Ion Batteries

    Directory of Open Access Journals (Sweden)

    Joanna Górka

    2016-12-01

    Full Text Available Sodium ion batteries (SIBs have attracted lots of attention over last few years due to the abundance and wide availability of sodium resources, making SIBs the most cost-effective alternative to the currently used lithium ion batteries (LIBs. Many efforts are underway to find effective anodes for SIBs since the commercial anode for LIBs, graphite, has shown very limited capacity for SIBs. Among many different types of carbons, hard carbons—especially these derived from biomass—hold a great deal of promise for SIB technology thanks to their constantly improving performance and low cost. The main scope of this mini-review is to present current progress in preparation of negative electrodes from biomass including aspects related to precursor types used and their impact on the final carbon characteristics (structure, texture and composition. Another aspect discussed is how certain macro- and microstructure characteristics of the materials translate to their performance as anode for Na-ion batteries. In the last part, current understanding of factors governing sodium insertion into hard carbons is summarized, specifically those that could help solve existing performance bottlenecks such as irreversible capacity, initial low Coulombic efficiency and poor rate performance.

  3. Recent progress in annihilation related studies by slow positrons

    International Nuclear Information System (INIS)

    Lynn, K.G.

    1989-01-01

    The field of slow-positron physics has expanded significantly in the last few years to include particles and atomic physics but has been most extensive in those associated with condensed matter or material science. This can primarily be attributed to the development of more efficient moderators. These moderators have been associated with both laboratory- and facility-based beams. In this paper I will focus only on the material-science aspects however. Positron can and are being used to examine all of the various fields. I feel the contribution in all these areas will be significant. I will primarily discuss those developments that have been developed in the area of interface science; a field that has both scientific and technological importance and has a limited number of nondestructive probes used in studying a buried interface. Interfaces are technologically important for applications such as electrical properties and mechanical properties. Such applications help to motivate the fundamental research of interface properties and dynamics, which is necessary to develop the basic understanding of new types of interfaces. The role of the interface is also important since it limited length of this paper. Results will be presented in interface studies that have occurred in the last year, including some unpublished results obtained at Brookhaven over the past few months. This field is in the early stages and I expect that the full utilization of this relatively new probe can be anticipated in the next few years. 17 refs., 7 figs

  4. Study of air pollution scavenging. Fourteenth progress report

    Energy Technology Data Exchange (ETDEWEB)

    Semonin, R.G.

    1976-04-01

    The field experiments were continued to estimate convective storm particulate scavenging efficiency in proximity to the St. Louis, Missouri urban-industrial complex. Complementary studies of the urban aerosol characterization, source strength, and removal processes were also studied. The 1975 field effort shifted emphasis from the immediate St. Louis area to the Alton-Wood River industrial complex. Along with the change in size and configuration of the network, there were increases in the numbers of most types of samplers. The new network yielded the following types of samples for analysis and interpretation: 1065 total rain samples from 85 sites; 68 sequential rainwater samples from 2 locations; 272 wet/dry samples from 7 locations; 216 air filter samples from 7 locations; 36 air filter samples from aircraft; and raindrop spectrometer data from 11 sites for the period 17 June-18 August. The analysis procedures require that all water samples undergo filtering for separate analyses of soluble and insoluble fractions of the elemental concentrations. This data collection effort provided a record number of samples for chemical analysis. Approximately 4000 pibals and over 370 radiosondes were released in the operational period, providing wind and thermodynamic data on 33 days. Aircraft missions were flown on 24 days, with one air tracer release of cesium on 19 July 1975. The status of the analysis of all types of data is described.

  5. Study of atmospheric pollution scavenging. Sixteenth progress report

    Energy Technology Data Exchange (ETDEWEB)

    Semonin, R.G.; Gatz, D.F.; Peden, M.E.; Stensland, G.J.

    1978-07-01

    The relative spatial variability of atmospheric deposition was studied for sampling networks of various areas in the U.S., Sweden, and the U.S.S.R. The data were derived from event, monthly, and yearly sample collection periods. The results indicate the relative variability for precipitation, chemical concentration of constituents, and the deposition increase in that order. A factor analysis approach to interpretation of the role of aerosol in altering rainfall is presented. The results indicate that either aerosol does not influence rainfall amount, or a critical chemical component of the aerosol was not included in the analysis. Careful analyses were carried out, comparing historical and current precipitation chemistry at Champaign-Urbana. The results show that the apparent high pH values of rainfall in 1954 were due to high values of calcium and magnesium and not due to low concentrations of sulfate and nitrogen species. New field efforts were initiated in 1978 in east-central Illinois to measure rain chemistry with improved precision over previous effort. The preliminary results from the first light rainshower show some puzzling relationships between the amount of rain and various chemical concentrations. The pH appears to be inversely related to rain volume, but other ionic species are not so easily identified with rain amount. The summer field experiment has, thus far, produced approximately 12 additional events which are in various stages of analysis. The study of the stability of ions in precipitation was continued and is the subject of additional proposed work. The results are very firm at this time, that either wet-only sampling must be carried out, or the sample must be preserved at 4/sup 0/C to retain the chemical integrity of the sample. It is recommended, however, that filtration of the sample be accomplished within 12 hours of the cessation of precipitation to ensure stability of the ionic composition.

  6. Study of atmospheric pollution scavenging. Eighteenth progress report

    Energy Technology Data Exchange (ETDEWEB)

    Semonin, R.G.; Bartlett, J.D.; Bowersox, V.C.; Gatz, D.F.; Naiman, D.Q.; Peden, M.E.; Stahlhut, R.K.; Stensland, G.J.

    1980-07-01

    The analysis of aerosol samples obtained in rural east-central Illinois reveals a seasonal maximum in SO/sub 4/ during May to July and a similar pattern for NH/sub 4/. The annual median SO/sub 4/ is about 1 to 1.5 ..mu..g/m/sup 3/. In contrast to these ions, NO/sub 3/ displays highest values in the cold season. Soil-related species (Ca, K) seem to maximize in relation to farm tillage and harvesting practices. The NO/sub 3/ in recent precipitation samples over the northeast US increased between 1 and 2 times the values observed in the mid-1950's. A case study from SCORE-78 suggests that all ion concentrations analyzed from sequentially collected samples decreased from the onset of rain to a minimum corresponding to the heaviest rain rates. Four groups of elements in 10 event rain samples were identified using factor analysis. The groups include soluble and insoluble crustal elements, soluble pollutant metals and sulfate, and insoluble pollutant metals. Utilizing the factor analysis approach, the St. Louis METROMEX precipitation chemistry data showed that the SO/sub 4/ deposition patterns group consistently with those of other soluble pollutants. Additional factor analysis efforts on the St. Louis rainwater data set revealed that soluble and insoluble concentrations of a given element have different deposition patterns suggesting that scavenging and/or precipitation formation processes dictate the patterns. An approach to managing the vast data base of rain chemistry used in the above studies is described. The software also examines the data for certain aspects of quality assurance. The procedures used to analyze ambient air filter samples are discussed.

  7. Idaho Steelhead Monitoring and Evaluation Studies : Annual Progress Report 2007.

    Energy Technology Data Exchange (ETDEWEB)

    Copeland, Timothy; Putnam, Scott

    2008-12-01

    The goal of Idaho Steelhead Monitoring and Evaluation Studies is to collect monitoring data to evaluate wild and natural steelhead populations in the Clearwater and Salmon river drainages. During 2007, intensive population data were collected in Fish Creek (Lochsa River tributary) and Rapid River (Little Salmon River tributary); extensive data were collected in other selected spawning tributaries. Weirs were operated in Fish Creek and Rapid River to estimate adult escapement and to collect samples for age determination and genetic analysis. Snorkel surveys were conducted in Fish Creek, Rapid River, and Boulder Creek (Little Salmon River tributary) to estimate parr density. Screw traps were operated in Fish Creek, Rapid River, Secesh River, and Big Creek to estimate juvenile emigrant abundance, to tag fish for survival estimation, and to collect samples for age determination and genetic analysis. The estimated wild adult steelhead escapement in Fish Creek was 81 fish and in Rapid River was 32 fish. We estimate that juvenile emigration was 24,127 fish from Fish Creek; 5,632 fish from Rapid River; and 43,674 fish from Big Creek. The Secesh trap was pulled for an extended period due to wildfires, so we did not estimate emigrant abundance for that location. In cooperation with Idaho Supplementation Studies, trap tenders PIT tagged 25,618 steelhead juveniles at 18 screw trap sites in the Clearwater and Salmon river drainages. To estimate age composition, 143 adult steelhead and 5,082 juvenile steelhead scale samples were collected. At the time of this report, 114 adult and 1,642 juvenile samples have been aged. Project personnel collected genetic samples from 122 adults and 839 juveniles. We sent 678 genetic samples to the IDFG Eagle Fish Genetics Laboratory for analysis. Water temperature was recorded at 37 locations in the Clearwater and Salmon river drainages.

  8. Comprehensive study of psi meson production. Progress report

    International Nuclear Information System (INIS)

    Jones, S.T.; Harms, B.C.

    1985-01-01

    Our first paper under this grant is a calculation of prompt lepton production in upsilon and toponium decay. The results should prove useful in identifying signals for charm or bottom production. Our work has led to some improvement in our understanding of psi production in hadronic interactions, although further work is needed. Attempts to explain the difference between experimental and theoretical rates of psi hadroproduction led to a study of quark-gluon scattering, which proved to have a negative impact on the theoretical cross section once a leading mass singularity was absorbed into the gluon distribution function. Our study of psi production in B meson decays has led to an improvement in the leading-log calculation of this rate, which gives a much more precise prediction of the decay rate. We have also calculated all first-order QCD corrections to this weak process. We are now completing a companion calculation of n/sub c/ production, for which there is presently no data. Dr. Harms and Dr. Cox have collaborated on an attempt to determine the dominant contribution to the difference sigma(pN → psi x) - sigma(anti pN → psi x). The lowest order process contributing to this difference (q anti q → psi GG) has been shown previously to be small. They have calculated the next order process (q anti q → G*G* → psi G) and have apparently uncovered a new example of the violation of the Bloch-Nordsieck mechanism in QCD. Our work outside the realm of QCD has included a new fit to the total pp and anti pp cross sections. Dr. Cox has also been pursuing the question of representations of extended (especially N=8) supersymmetry

  9. Interactive design computation : A case study on quantum design paradigm

    NARCIS (Netherlands)

    Feng, H.

    2013-01-01

    The ever-increasing complexity of design processes fosters novel design computation models to be employed in architectural research and design in order to facilitate accurate data processing and refined decision making. These computation models have enabled designers to work with complex geometry

  10. Rhetorical Design Studies: The Art of Making Design Choices Explicit

    DEFF Research Database (Denmark)

    Halstrøm, Per L.

    2017-01-01

    Design has the potential to affect the situations we are in, the choices we make and the beliefs we live by. Being such an affective field, one might expect that canonized design thinking models and methods would be much concerned with how designers can discover arguments for their design choices...

  11. Towards an advanced design for MYRRHA. Development of the primary system is progressively taking shape

    International Nuclear Information System (INIS)

    2015-01-01

    In recent years, the Belgian Nuclear Research Centre SCK-CEN has been developing a versatile irradiation facility, which will replace the current BR2 research reactor in the future. This 'Multi-purpose hYbrid Research Reactor for High-tech Applications', MYRRHA for short, is designed to be a system driven by an accelerator (Advanced Nuclear System or ADS). Such an ADS consists of a particle accelerator linked to a subcritical reactor. MYRRHA is also able to operate in critical mode like a classic reactor. Scientists and engineers have been working on the development of the MYRRHA reactor without interruption since 1998. A new revision in 2014 again brought them a step closer to completion. The article discusses the current status and several challenges, related to both the budget and the technical aspects of the design.

  12. Progress in the design of the ITER Neutral Beam cell Remote Handling System

    Energy Technology Data Exchange (ETDEWEB)

    Shuff, R., E-mail: robin.shuff@f4e.europa.eu [Fusion for Energy, Torres Diagonal Litoral B3, Josep Pla 2, 08019 Barcelona (Spain); Van Uffelen, M.; Damiani, C. [Fusion for Energy, Torres Diagonal Litoral B3, Josep Pla 2, 08019 Barcelona (Spain); Tesini, A.; Choi, C.-H. [ITER Organization, Route de Vinon sur Verdon, 13115 Saint Paul-lez-Durance (France); Meek, R. [Oxford Technologies Limited, 7 Nuffield Way, Abingdon OX14 1RL (United Kingdom)

    2014-10-15

    The ITER Neutral Beam cell will include a suite of Remote Handling equipment for maintenance tasks. This paper summarises the current status and recent developments in the design of the ITER Neutral Beam Remote Handling System. Its concept design was successfully completed in July 2012 by CCFE in the frame of a grant agreement with F4E, in collaboration with the ITER Organisation, including major systems like monorail crane, Beam Line Transporter, beam source equipment, upper port and neutron shield equipment and associated tooling. Research and development activities are now underway on the monorail crane radiation hardened on-board control system and first of a kind remote pipe and lip seal maintenance tooling for the beam line vessel, reported in this paper.

  13. Progress in design and development of series liquid lithium-lead expeirmental loops in China

    International Nuclear Information System (INIS)

    Wu Yican; Huang Qunying; Zhu Zhiqiang; Gao Sheng; Song Yong; Li Chunjing; Peng Lei; Liu Shaojun; Wu qingsheng; Liu Songlin; Chen Hongli; Bai Yunqing; Jin Ming; Lv Ruojun; Wang Weihua; Guo Zhihui; Chen Yaping; Ling Xinzhen; Zhang Maolian; Wang Yongliang; Wu Zhaoyang; Wang Hongyan

    2009-01-01

    Liquid LiPb (lithium-lead) experimental loops are the important platforms to investigate the key technologies of liquid LiPb breeder blankets for fusion reactors. Based on the development strategy for liquid LiPb breeder blankets, the technologies development of liquid LiPb experimental loops have been explored by the FDS Team for years, and a series of LiPb experimental loops named DRAGON have been designed and developed, which have independence intellectual property and multi-functional parameters. In this paper, the development route suggestion of Chinese LiPb experimental loops was elaborated, and some information for the senes experimental loops were introduced, such as the design principles, structural features, functions and related experimental researches, etc. (authors)

  14. Progress in the design of a superconducting toroidal magnet for the ATLAS detector on LHC

    International Nuclear Information System (INIS)

    Baze, J.M.; Berriaud, C.; Cure, C.

    1996-01-01

    The toroidal system consists of three air core superconducting toroids. The barrel toroid covers the central region over a length of 26 m with an inner bore of 9.4 m and an outer diameter of 19.5 m. The two end cap toroids are inserted in the barrel at each end over a length of 5.6 m with an inner bore of 1.26 m. Each toroid consists of eight flat coils assembled around the beam axis and carrying 3 MAt each. The present paper describes the barrel toroid. Features of the design which are presented include the electromagnetic design, field and forces calculations, the basic concept of indirectly cooled aluminium conductor and monolithic fully impregnated winding, the description of the alu-alloy mechanical structure, the thermal analysis and the quench protection. Cryogenics principles, cryostat and toroid assembly procedures are summarized. Unsymmetric loadings, fault sensing and stability are discussed, in relation with the requirements of transparency

  15. Progress in the design of the ITER Neutral Beam cell Remote Handling System

    International Nuclear Information System (INIS)

    Shuff, R.; Van Uffelen, M.; Damiani, C.; Tesini, A.; Choi, C.-H.; Meek, R.

    2014-01-01

    The ITER Neutral Beam cell will include a suite of Remote Handling equipment for maintenance tasks. This paper summarises the current status and recent developments in the design of the ITER Neutral Beam Remote Handling System. Its concept design was successfully completed in July 2012 by CCFE in the frame of a grant agreement with F4E, in collaboration with the ITER Organisation, including major systems like monorail crane, Beam Line Transporter, beam source equipment, upper port and neutron shield equipment and associated tooling. Research and development activities are now underway on the monorail crane radiation hardened on-board control system and first of a kind remote pipe and lip seal maintenance tooling for the beam line vessel, reported in this paper

  16. Statement on current progress of the EPR project. Basic Design phase concluded

    International Nuclear Information System (INIS)

    Lamprecht, F.

    1997-01-01

    Against the background of expected increasing demand for electric power worldwide it is obvious that any existing technology for electricity generation will be required in the future to meet the demand, just as well as technology improvements. Nuclear industry's answer to this challenge are activities for further evolution of the PWR concept as a joint venture of France and Germany for development of the European Pressurized Water Reactor (EPR). The project participants are reactor manufacturers and operators of both countries as well as organisations responsible for reactor safety. The Basic Design phase which started in 1995, after prior definition of the common safety philosophy, has recently been concluded. The results have been presented at a meeting in October 1997 in Cologne, organised by KTG and SFEN, the countries' respective nuclear societies. The broad statement is that project work was successful in achieving two major objectives: A well-balanced safety concept, and a competitive design. (orig./CB) [de

  17. Electromagnetic analysis, structural integrity and progress on mechanical design of the ITER ferromagnetic insert

    Energy Technology Data Exchange (ETDEWEB)

    Morimoto, M. [Mitsubishi Heavy Industries, Ltd., 1-1 Wadasaki-cho 1-chome, Hyogo-ku, Kobe 652-8585 (Japan)], E-mail: masaaki_morimoto@maia.eonet.ne.jp; Ioki, K.; Terasawa, A.; Utin, Yu.; Barabash, V.; Gribov, Y. [ITER Organization, 13108 St. Paul lez Durance (France)

    2009-12-15

    Ferromagnetic material is used to reduce the toroidal field ripple in JFT-2M and JT-60U . In ITER, since the ferromagnetic material is inserted in the space between the double walls of ITER Vacuum Vessel (VV), it is called 'ferromagnetic inserts'. Suitable material is selected to satisfy the design requirements of ITER. The proper location and amount of the ferromagnetic inserts are optimized with the goal of reduction of the toroidal field ripple. The ferromagnetic inserts are designed to minimize electromagnetic forces acting on them. The electromagnetic forces have been calculated with the latest disruption scenarios. Magnetization forces due to magnetic fields have also been calculated. Structural integrity has been validated by a structural analysis.

  18. A Modular Design for Geo-Distributed Querying : Work in Progress Report

    OpenAIRE

    Vasilas , Dimitrios; Shapiro , Marc; King , Bradley

    2018-01-01

    International audience; Most distributed storage systems provide limited abilities for querying data by attributes other than their primary keys. Supporting efficient search on secondary attributes is challenging as applications pose varying requirements to query processing systems, and no single system design can be suitable for all needs. In this paper, we show how to overcome these challenges in order to extend distributed data stores to support queries on secondary attributes. We propose ...

  19. REBL: design progress toward 16 nm half-pitch maskless projection electron beam lithography

    Science.gov (United States)

    McCord, Mark A.; Petric, Paul; Ummethala, Upendra; Carroll, Allen; Kojima, Shinichi; Grella, Luca; Shriyan, Sameet; Rettner, Charles T.; Bevis, Chris F.

    2012-03-01

    REBL (Reflective Electron Beam Lithography) is a novel concept for high speed maskless projection electron beam lithography. Originally targeting 45 nm HP (half pitch) under a DARPA funded contract, we are now working on optimizing the optics and architecture for the commercial silicon integrated circuit fabrication market at the equivalent of 16 nm HP. The shift to smaller features requires innovation in most major subsystems of the tool, including optics, stage, and metrology. We also require better simulation and understanding of the exposure process. In order to meet blur requirements for 16 nm lithography, we are both shrinking the pixel size and reducing the beam current. Throughput will be maintained by increasing the number of columns as well as other design optimizations. In consequence, the maximum stage speed required to meet wafer throughput targets at 16 nm will be much less than originally planned for at 45 nm. As a result, we are changing the stage architecture from a rotary design to a linear design that can still meet the throughput requirements but with more conventional technology that entails less technical risk. The linear concept also allows for simplifications in the datapath, primarily from being able to reuse pattern data across dies and columns. Finally, we are now able to demonstrate working dynamic pattern generator (DPG) chips, CMOS chips with microfabricated lenslets on top to prevent crosstalk between pixels.

  20. Progress report on the design of a Low-Level Waste Pilot Facility at ORNL

    International Nuclear Information System (INIS)

    Hensley, L.C.; Turner, V.L.; Pruitt, A.S.

    1980-01-01

    All low-level radioactive solid wastes, excluding TRU wastes, are disposed of by shallow land burial at the Oak Ridge National Laboratory. Contaminated liquids and sludges are hydrofractures. The TRU wastes are stored in a retrievable fashion in concrete storage facilities. Currently, the capacity for low-level radioactive waste burial at the Oak Ridge National Laboratory is adequate for another six years of service at the current solids disposal rate which ranges between 80,000 and 100,000 cu ft per year. Decontamination and decommissioning of a number of ORNL facilities will be a significant activity in the next few years. Quantities of radioactive materials to be stored or disposed of as a result of these activities will be large; therefore, the technology to dispose of large quantities of low-level radioactive wastes must be demonstrated. The UCC-ND Engineering Division, in concert with divisions of the Oak Ridge National Laboratory, has been requested to prepare a conceptual design for a facility to both dispose of the currently produced low-level radioactive waste and also to provide a test bed for demonstration of other processes which may be used in future low-level radioactive wastes disposal facilities. This facility is designated as the Low-Level Waste Pilot Facility (LLWPF). This paper describes the status of the conceptual design of a facility for disposal of the subject radioactive waste

  1. Progress on qualification testing methodology study of electric cables

    International Nuclear Information System (INIS)

    Yoshida, K.; Seguchi, T.; Okada, S.; Ito, M.; Kusama, Y.; Yagi, T.; Yoshikawa, M.

    1983-01-01

    Many instrumental, control and power cables are installed in nuclear power plants, and these cables contain a large amount of organic polymers as insulating and jacketing materials. They are exposed to radiation at high dose rate, steam at high temperature and chemical (or water) spray simultaneously when a LOCA occurs. Under such conditions, the polymers tend to lose their original properties. For reactor safety, the cables should be functional even if they are subjected to a loss-of-coolant accident (LOCA) at the end of their intended service life. In Japan, cable manufacturers qualify their cables according to the proposed test standard issued from IEEJ in 1982, but the standard still has many unsolved problems or uncertainties which have been dealt with tentatively through the manufacturer-user's agreement. The objectives of this research are to study the methodologies for qualification testing of electric wires and cables, and to provide the improved technical bases for modification of the standard. Research activities are divided into the Accident (LOCA) Testing Methodology and the Accelerated Aging Methodology

  2. Molecular studies of functional aspects of plant mitochondria. Progress report

    Energy Technology Data Exchange (ETDEWEB)

    Siedow, J.N.

    1992-03-03

    The goal of this research is to characterize the mechanism by which a protein encoded by mitochondrial genome of cms-T maize (URF13) interacts with a family of the compounds produced by certain fungi (T-toxins) to permeabilize biological membranes. The research carried out during the current funding period has focused on the structure of URF13, and the results support the validity of the three-helix model of URF13 and provide direct evidence for the oligomeric nature of at least some of the URF13 molecules in the membrane. In addition, the toxin binding studies have provided insight into the dynamic nature of the T-toxin:URF13 interaction and the extent to which Asp-39 is crucial to the interaction that leads to membrane pore formation. Additional knowledge of the structure of URF13 is needed if the nature of the interaction between URF13 and T-toxin to produce a hydrophilic pore within the membrane is to ultimately be understood.

  3. Study on the Progress of Ecological Fragility Assessment in China

    Science.gov (United States)

    Chen, Pei; Hou, Kang; Chang, Yue; Li, Xuxiang; Zhang, Yunwei

    2018-02-01

    The basic elements of human survival are based on the ecological environment. The development of social economic and the security of the ecological environment are closely linked and interact with each other. The fragility of the environment directly affects the stability of the regional ecosystem and the sustainable development of the ecological environment. As part of the division of the national ecological security, the assessment of ecological fragility has become a hot and difficult issue in environmental research, and researchers at home and abroad have systematically studied the causes and states of ecological fragility. The assessment of regional ecological fragility is a qualitative and quantitative analysis of the unbalanced distribution of ecological environment factors caused by human socio-economic activities or changes in ecosystems. At present, researches on ecological fragility has not formed a complete and unified index assessment system, and the unity of the assessment model has a direct impact on the accuracy of the index weights. Therefore, the discussion on selection of ecological fragility indexes and the improvement of ecological fragility assessment model is necessary, which is good for the improvement of ecological fragility assessment system in China.

  4. Progressive resistance training in head and neck cancer patients during concomitant chemoradiotherapy -- design of the DAHANCA 31 randomized trial

    DEFF Research Database (Denmark)

    Lonkvist, Camilla K; Lønbro, Simon; Vinther, Anders

    2017-01-01

    . This randomized study investigates whether progressive resistance training (PRT) may attenuate loss of muscle mass and functional performance. Furthermore, biochemical markers and muscle biopsies will be investigated trying to link biological mechanisms to training effects. METHODS: At the Departments of Oncology...... content in muscles, as well as muscle fiber type and fiber size in muscle biopsies. Muscle biopsies are optional. DISCUSSION: This randomized study investigates the impact of a 12-week progressive resistance training program on lean body mass and several other physiological endpoints, as well as impact...... on adverse events and quality of life. Furthermore, a translational approach is integrated with extensive biological sampling and exploration into cytokines and mechanisms involved. The current paper discusses decisions and methods behind exercise in head and neck cancer patients undergoing concomitant...

  5. Optimal design and routing of power lines; ecological, technical and economic perspectives (OPTIPOL). Progress report 2012

    Energy Technology Data Exchange (ETDEWEB)

    Bevanger, Kjetil; Bartzke, Gundula; Broeseth, Henrik; Dahl, Espen Lie; Gjershaug, Jan Ove; Hanssen, Frank; Jacobsen, Karl-Otto; Kleven, Oddmund; Kvaloey, Paal; May, Roel; Meaas, Roger; Nygaaard, Torgeir; Resnaes, Steinar; Stokke, Sigbjoern; Thomassen, Joern

    2012-07-01

    birds in the database, compared to only 117 a year earlier. WP5 - 'A Least Cost Path (LCP) toolbox for optimal route routing of power lines', has developed an LCP-pilot to demonstrate the LCP method, based on the impact studies were undertaken prior to construction of a 420 kV transmission line in Central Norway 2005. Relevant economic, ecological and technological environment criteria based on suggestions from interested users (NGOs, government, industry, etc.), was used. LCP-pilot and a fuzzy-logic approach of this was demonstrated in the first dialogue-based workshop, 23.-24. april 2012. The seminar, which had an emphasis on criteria definitions were followed up with a working seminar that focused criterion values ??on 20 november 2012. Lecture - 'A Least Cost Path (LCP) Toolbox for Optimal Routing of Power Lines, -was presented and submitted as contributions to the conference report from 'The 10th ROW Conference' in Arizona, 'The 32nd Annual Conference of the International Association for Impact Assessment (IAIA12) ' in Porto, Portugal, and 'The ESRI European User Conference' in Oslo. WP6 - 'Birds and camouflaging of power lines', has almost completed the final report, 'Power line camouflaging. An assessment of the ecological and technical challenges'. 'Because of the budget situation in CEDREN However, completion of the report postponed until the end of April 2013. WP7 - 'Effect of line marking / modifications remedial measures against bird mortality' has almost completed the final report 'Opportunities and limitations in terms of reducing mortality in birds due to collision and electrocution.' Due to overall budget situation in CEDREN the report deferred to the end of april 2013. WP8, 'guidelines for technological solutions that may reduce mortality in birds because of the power line's', has focused topics relating to the labeling, design, insulation, camouflage and wiring. The results, which are presented in the notes and articles, will be implemented in

  6. Design Research on Mathematics Education: Investigating The Progress of Indonesian Fifth Grade Students’ Learning on Multiplication of Fractions With Natural Numbers

    Directory of Open Access Journals (Sweden)

    Nenden Octavarulia Shanty

    2011-07-01

    Full Text Available This study aimed at investigating the progress of students’ learning onmultiplication fractions with natural numbers through the five activitylevels based on Realistic Mathematics Education (RME approachproposed by Streefland. Design research was chosen to achieve thisresearch goal. In design research, the Hypothetical Learning Trajectory(HLT plays important role as a design and research instrument. ThisHLT tested to thirty-seven students of grade five primary school (i.e.SDN 179 Palembang.The result of the classroom practices showed that measurement (lengthactivity could stimulate students’ to produce fractions as the first levelin learning multiplication of fractions with natural numbers.Furthermore, strategies and tools used by the students in partitioninggradually be developed into a more formal mathematics in whichnumber line be used as the model of measuring situation and the modelfor more formal reasoning. The number line then could bring thestudents to the last activity level, namely on the way to rules formultiplying fractions with natural numbers. Based on this findings, it is suggested that Streefland’s five activity levels can be used as aguideline in learning multiplication of fractions with natural numbers in which the learning process become a more progressive learning.

  7. Progress on building design and site layout, and preparation for procurement

    International Nuclear Information System (INIS)

    Haange, R.

    2004-01-01

    The ITER site layout and buildings retain many of the major features worked out for the original 1998 design of ITER. By mid-2001, the design had been adjusted to take account of the reductions in size of the tokamak and in the performance and capability of its supporting plant systems, with a view to providing a building construction cost reduction near the target of 50%. The present status of the site layout and buildings is that, with the exception of the hot cell building, designs are available for the ITER buildings and site layout, in different degrees of detail, ready for final review as soon as the drawings and 3D models have been updated. The ITER site layout is determined by the functions of the various plant systems provided in support of the ITER tokamak. These systems are located in different buildings on the ITER site. Changes in the plant layout inside buildings can, therefore, have an important impact on the overall site layout. The general layout of the site assumes electrical power comes in from the west, heat rejection is on the east, access into the main building for assembly is from the south, and removal of waste is from the north. These orientations are purely notional, determining only the relative positions. Both the European and Japanese potential ITER sites will most likely use seismic isolation of the main tokamak complex. As a result, the detailed design of these buildings and in particular the piping connections to them developed for the 'generic' ITER site will require redesign. Also, the footprint of the main tokamak complex will increase, and hence the layout of the utility tunnel network will have to be updated. A draft Site Facilities Procurement Specification has been written by the International Team. This will require considerable specific input when the site has been selected. Furthermore, the present site layout will have to be reviewed in detail. The generic site has been kept compact. Once a site is available, it may be

  8. Progress in development and design aspects of advanced water cooled reactors

    International Nuclear Information System (INIS)

    1992-12-01

    The objective of the Technical Committee Meeting (TCM) was to provide an international forum for technical specialists to review and discuss technology developments and design work for advanced water cooled reactors, safety approaches and features of current water cooled reactors and to identify, understand and describe advanced features for safety and operational improvements. The TCM was attended by 92 participants representing 18 countries and two international organizations and included 40 presentations by authors of 14 countries and one international organization. A separate abstract was prepared for each of these presentations. Refs, figs, tabs

  9. The Use of Organising Purposes in Science Instruction as a Scaffolding Mechanism to Support Progressions: A Study of Talk in Two Primary Science Classrooms

    Science.gov (United States)

    Johansson, Annie-Maj; Wickman, Per-Olof

    2018-01-01

    Purpose: This study examines how different purposes can support teachers in their work with progressions as a part of a teaching sequences in science in primary school. Design/Method: The study was carried out in two classes working with inquiry and the events that took place in the classroom were filmed. In the study, we have chosen to use the…

  10. Improving the analysis of designed studies by combining statistical modelling with study design information

    NARCIS (Netherlands)

    Thissen, U.; Wopereis, S.; Berg, S.A.A. van den; Bobeldijk, I.; Kleemann, R.; Kooistra, T.; Dijk, K.W. van; Ommen, B. van; Smilde, A.K.

    2009-01-01

    Background: In the fields of life sciences, so-called designed studies are used for studying complex biological systems. The data derived from these studies comply with a study design aimed at generating relevant information while diminishing unwanted variation (noise). Knowledge about the study

  11. Controlled air incinerator conceptual design study

    International Nuclear Information System (INIS)

    1982-01-01

    This report presents a conceptual design study for a controlled air incinerator facility for incineration of low level combustible waste at Three Mile Island Unit 2 (TMI-2). The facility design is based on the use of a Helix Process Systems controlled air incinerator. Cost estimates and associated engineering, procurement, and construction schedules are also provided. The cost estimates and schedules are presented for two incinerator facility designs, one with provisions for waste ash solidification, the other with provisions for packaging the waste ash for transport to an undefined location

  12. Engineering study for ISSTRS design concept

    Energy Technology Data Exchange (ETDEWEB)

    Hertzel, J.S.

    1997-01-31

    Los Alamos Technical Associates, Inc., is pleased to transmit the attached Conceptual Design Package for the Initial Single Shell Tank Retrieval System (ISSTRS), 90% Conceptual Design Review. The package includes the following: (1) ISSTRS Trade Studies: (a) Retrieval Facility Cooling Requirements; (b) Equipment Re-usability between Project W-320 and Tanks 241-C-103 and 241-C-1 05; (c) Sluice Line Options; and (d) Options for the Location of Tanks AX-103 and A-1 02 HVAC Equipment; (2) Drawings; (3) Risk Management Plan; (4) 0850 Interface Control Document; (5) Requirements Traceability Report; and (6) Project Design Specification.

  13. Design of a mechanical system in gait rehabilitation with progressive addition of weight

    Science.gov (United States)

    Braidot, Ariel A. A.; Aleman, Guillermo L.

    2011-12-01

    In this paper we designed and developed a mechanical device for gait rehabilitation based on the application of "partial body weight reduction therapy". An evaluation of the characteristics of devices based on this therapy currently available on the market was carried out obtaining information of the different mechanisms used in it. The device was designed to adapt to different height and weight of patients and to be used with additional equipment in gait rehabilitation, for example, treadmills, elliptical trainers and vertical scalers. It was envisaged to be used by patients with asymmetry in the lower extremities capabilities. We developed a stable structure in steel ASTM A36 which does not depend on the building conditions of the installation site. RamAdvanse software was used to calculate structural stability. A winch with automatic brake mechanism was used to raise/lower the patient, who was tied to a comfortable harness which provided safety to the patient and therapist. It was possible to quantify precisely, using counterweights, the weight borne by the patient during therapy. We obtained a small-sized and ergonomic low-cost prototype, with similar features to those currently considered cutting-edge devices.

  14. A cosmopolitan design of teacher education and a progressive orientation towards the highest good

    Directory of Open Access Journals (Sweden)

    Klas Roth

    2013-01-01

    Full Text Available In this paper I discuss a Kantian conception of cosmopolitan education. It suggests that we pursue the highest good – an object of morality – in the world together, and requires that we acknowledge the value of freedom, render ourselves both efficacious and autonomous in practice, cultivate our judgment, and unselfishly co-operate in the co-ordination and fulfilment of our morally permissible ends. Now, such an accomplishment is one of the most difficult challenges, and may not be achieved in our time, if ever. In the first part of the paper I show that we, according to Kant, have to interact with each other, and comply with the moral law in the quest of general happiness, not merely personal happiness. In the second part, I argue that a cosmopolitan design of teacher education in Kantian terms can establish moral character, even though good moral character is ultimately the outcome of free choice. Such a design can do so by optimizing the freedom of those concerned to set and pursue their morally permissible ends, and to cultivate their judgment through the use of examples. This requires, inter alia, that they be enabled, and take responsibility, to think for themselves, in the position of everyone else, and consistently; and to strengthen their virtue or self-mastery to comply, in practice, with the moral law.

  15. Design of a mechanical system in gait rehabilitation with progressive addition of weight

    International Nuclear Information System (INIS)

    Braidot, Ariel A A; Aleman, Guillermo L

    2011-01-01

    In this paper we designed and developed a mechanical device for gait rehabilitation based on the application of p artial body weight reduction therapy . An evaluation of the characteristics of devices based on this therapy currently available on the market was carried out obtaining information of the different mechanisms used in it. The device was designed to adapt to different height and weight of patients and to be used with additional equipment in gait rehabilitation, for example, treadmills, elliptical trainers and vertical scalers. It was envisaged to be used by patients with asymmetry in the lower extremities capabilities. We developed a stable structure in steel ASTM A36 which does not depend on the building conditions of the installation site. RamAdvanse software was used to calculate structural stability. A winch with automatic brake mechanism was used to raise/lower the patient, who was tied to a comfortable harness which provided safety to the patient and therapist. It was possible to quantify precisely, using counterweights, the weight borne by the patient during therapy. We obtained a small-sized and ergonomic low-cost prototype, with similar features to those currently considered cutting-edge devices.

  16. Progress towards developing consistent design and evaluation guidelines for DOE facilities subjected to natural phenomena hazards

    International Nuclear Information System (INIS)

    Kennedy, R.P.; Short, S.A.; McDonald, J.R.; McCann, M.W. Jr.; Reed, J.W.

    1985-01-01

    Probabilistic definitions of earthquake, wind and tornado natural phenomena hazards for many Department of Energy (DOE) facilities throughout the United States have been developed. In addition, definitions of the flood hazards which might affect these locations are currently being developed. The Department of Energy Natural Phenomena Hazards Panel is now preparing a document to provide guidance and criteria for DOE facility managers to assure that DOE facilities are adequately constructed to resist the effects of natural phenomena such as earthquake, strong wind and flood. The intent of this document is to provide instruction on how to utilize the hazard definitions to evaluate existing facilities and design new facilities in a manner such that the risk of adverse consequences is consistent with the cost, function, and danger to the public or environment of the facility. Potential effects on facilities of natural phenomena hazards are emphasized in this paper. The philosophy for mitigating these effects to be employed in the design and evaluation guidelines is also presented

  17. Extrap conceptual fusion reactor design study

    International Nuclear Information System (INIS)

    Eninger, J.E; Lehnert, B.

    1987-12-01

    A study has recently been initiated to asses the fusion reactor potential of the Extrap concept. A reactor model is defined that fulfills certain economic and environmental criteria. This model is applied to Extrap and a reference reactor is outlined. The design is optimized by varying parameters subject to both physics and engineering constraints. Several design options are examined and key engineering issues are identified and addressed. Some preliminary results and conclusions of this work are summarized. (authors)

  18. Design study of laser fusion rocket

    International Nuclear Information System (INIS)

    Nakashima, Hideki; Shoyama, Hidetoshi; Kanda, Yukinori

    1991-01-01

    A design study was made on a rocket powered by laser fusion. Dependence of its flight performance on target gain, driver repetition rate and fuel composition was analyzed to obtain optimal design parameters of the laser fusion rocket. The results indicate that the laser fusion rocket fueled with DT or D 3 He has the potential advantages over other propulsion systems such as fission rocket for interplanetary travel. (author)

  19. Distribution Network Design--literature study based

    OpenAIRE

    LI, ANG

    2012-01-01

    The focus of this research is companies' outbound distribution network design in supply chain management. Within the present competitive market, it is a fundamental importance for companies to achieve high level business performance with an effective supply chain. Outbound distribution network design as an important part in supply chain management, to a large extent decides whether companies can fulfill customers' requirement or not. Therefore, such a study is important for manufacturers and ...

  20. Schematic representation of case study research designs.

    Science.gov (United States)

    Rosenberg, John P; Yates, Patsy M

    2007-11-01

    The paper is a report of a study to demonstrate how the use of schematics can provide procedural clarity and promote rigour in the conduct of case study research. Case study research is a methodologically flexible approach to research design that focuses on a particular case - whether an individual, a collective or a phenomenon of interest. It is known as the 'study of the particular' for its thorough investigation of particular, real-life situations and is gaining increased attention in nursing and social research. However, the methodological flexibility it offers can leave the novice researcher uncertain of suitable procedural steps required to ensure methodological rigour. This article provides a real example of a case study research design that utilizes schematic representation drawn from a doctoral study of the integration of health promotion principles and practices into a palliative care organization. The issues discussed are: (1) the definition and application of case study research design; (2) the application of schematics in research; (3) the procedural steps and their contribution to the maintenance of rigour; and (4) the benefits and risks of schematics in case study research. The inclusion of visual representations of design with accompanying explanatory text is recommended in reporting case study research methods.

  1. Conceptual study of advanced PWR core design

    International Nuclear Information System (INIS)

    Kim, Young Jin; Chang, Moon Hee; Kim, Keung Ku; Joo, Hyung Kuk; Kim, Young Il; Noh, Jae Man; Hwang, Dae Hyun; Kim, Taek Kyum; Yoo, Yon Jong.

    1997-09-01

    The purpose of this project is for developing and verifying the core design concepts with enhanced safety and economy, and associated methodologies for core analyses. From the study of the sate-of-art of foreign advanced reactor cores, we developed core concepts such as soluble boron free, high convertible and enhanced safety core loaded semi-tight lattice hexagonal fuel assemblies. To analyze this hexagonal core, we have developed and verified some neutronic and T/H analysis methodologies. HELIOS code was adopted as the assembly code and HEXFEM code was developed for hexagonal core analysis. Based on experimental data in hexagonal lattices and the COBRA-IV-I code, we developed a thermal-hydraulic analysis code for hexagonal lattices. Using the core analysis code systems developed in this project, we designed a 600 MWe core and studied the feasibility of the core concepts. Two additional scopes were performed in this project : study on the operational strategies of soluble boron free core and conceptual design of large scale passive core. By using the axial BP zoning concept and suitable design of control rods, this project showed that it was possible to design a soluble boron free core in 600 MWe PWR. The results of large scale core design showed that passive concepts and daily load follow operation could be practiced. (author). 15 refs., 52 tabs., 101 figs

  2. Conceptual study of advanced PWR core design

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Young Jin; Chang, Moon Hee; Kim, Keung Ku; Joo, Hyung Kuk; Kim, Young Il; Noh, Jae Man; Hwang, Dae Hyun; Kim, Taek Kyum; Yoo, Yon Jong

    1997-09-01

    The purpose of this project is for developing and verifying the core design concepts with enhanced safety and economy, and associated methodologies for core analyses. From the study of the sate-of-art of foreign advanced reactor cores, we developed core concepts such as soluble boron free, high convertible and enhanced safety core loaded semi-tight lattice hexagonal fuel assemblies. To analyze this hexagonal core, we have developed and verified some neutronic and T/H analysis methodologies. HELIOS code was adopted as the assembly code and HEXFEM code was developed for hexagonal core analysis. Based on experimental data in hexagonal lattices and the COBRA-IV-I code, we developed a thermal-hydraulic analysis code for hexagonal lattices. Using the core analysis code systems developed in this project, we designed a 600 MWe core and studied the feasibility of the core concepts. Two additional scopes were performed in this project : study on the operational strategies of soluble boron free core and conceptual design of large scale passive core. By using the axial BP zoning concept and suitable design of control rods, this project showed that it was possible to design a soluble boron free core in 600 MWe PWR. The results of large scale core design showed that passive concepts and daily load follow operation could be practiced. (author). 15 refs., 52 tabs., 101 figs.

  3. The Role of Time Perspective, Motivation, Attitude, and Preparation in Educational Choice and Study Progress

    NARCIS (Netherlands)

    Slijper, Jeany; Kunnen, Elske; Onstenk, Jeroen; van Geert, Paul

    2016-01-01

    The present study examined the relation between study progress in the first year of education and different aspects of the process of study choice of 89 students of higher professional education. This study consists of three parts. Firstly, we explored which concepts are important in open interviews

  4. Status of Conceptual Design Progress for ITER Sector Sub-assembly Tools

    Energy Technology Data Exchange (ETDEWEB)

    Nam, Kyoung O; Park, Hyun Ki; Kim, Dong Jin [National Fusion Research Institute, Daejeon (Korea, Republic of); Lee, Jae Hyuk; Kim, Kyung Kyu [SFA Engineering Corp., Changwon (Korea, Republic of); Im, Ki Hak; Robert, Shaw [ITER Organization, Paul lez Durance (France)

    2010-05-15

    The ITER (International Thermonuclear Experimental Reactor) Tokamak assembly tools are purpose-built tools to complete the ITER Tokamak machine which includes the cryostat and the components contained therein. Based on the design description document prepared by the ITER organization, Korea has carried out the conceptual design of assembly tools. The 40 .deg. sector assemblies sub-assembled at assembly hall are transferred to Tokamak hall using the lifting tool operated by Tokamak main cranes. In-pit assembly tools are the purpose-built assembly tools for the completion of final sector assembly at Tokamak hall. The 40 .deg. sector sub-assembly tools are composed of the upending tool, the sector sub-assembly tool, the sector lifting tool and the vacuum vessel support and bracing tools. The process of the ITER sector sub-assembly at assembly hall and status of research and development are described in this paper. The ITER Tokamak device is composed of 9 vacuum vessel (VV)/toroidal field coils (TFCs)/vacuum vessel thermal shields (VVTS) 40 .deg. sectors. Each VV/TFCs/VVTS 40 .deg. sector is made up of one 40 .deg. VV, two 20 .deg. TFCs and associated VVTS segments. The 40 .deg. sectors are sub-assembled at assembly hall respectively and then 9 sectors which sub-assembled at assembly hall are finally assembled at Tokamak hall. As a basic assembly component, the assembly strategy and tools for the 40 .deg. sector sub-assembly and final assembly at inpit should be developed to satisfy the basic assembly requirements of the ITER Tokamak device. Accordingly, the purpose-built assembly tools should be designed and manufactured considering assembly plan, available space, safety, easy operation, efficient maintenance, and so on. The 40 .deg. sector assembly tools are classified into 2 groups. One group is the sub-assembly tools including upending tool, lifting tool, sub-assembly tool, VV supports and bracing tools used at assembly hall and the other group is the in

  5. Progress in the Design of the Stabilized Liner Compressor for MTF/MIF Plasma Target Development

    Science.gov (United States)

    Frese, Sherry; Frese, Michael; Turchi, Peter; Gale, Don

    2016-10-01

    The Stabilized Liner Compressor (SLC) seeks to extend concepts for repetitive, rotationally stabilized, liquid-metal liners driven by free-pistons to much higher drive pressures (25 vs 5 kpsi) and faster implosion speeds (2000 vs 100 m/s) than previously demonstrated. Such extension is needed to enable experiments with magnetized-plasma targets presently offering sizes and lifetimes of 10's cm diam and 10's microsec. SLC represents the confluence of several difficult technologies, including pulsed high pressures, high-speed rotating machinery and alkali-metal (Na, NaK) handling. Solution of the two-dimensional, unsteady, compressible flow of a rotating liquid-metal liner requires advanced numerical techniques. We report the use of the 2-1/2 dimensional MHD code MACH2 to explore flow options, including magnetic flux compression, and to provide pulsed pressure distributions for mechanical design. Supported by ARPA-E ALPHA Program.

  6. Architectural design criteria for f-block metal ion sequestering agents. 1998 annual progress report

    International Nuclear Information System (INIS)

    Dixon, D.A.; Hay, B.P.; Paine, R.T.; Raymond, K.N.; Rogers, R.D.; Roundhill, D.M.

    1998-01-01

    'The objective of this project is to provide a means to optimize ligand architecture for f-block metal recognition. The authors strategy builds on an innovative and successful molecular modeling approach in developing polyether ligand design criteria for the alkali and alkaline earth cations. The hypothesis underlying this proposal is that differences in metal ion binding with multidentate ligands bearing the same number and type of donor groups are primarily attributable to intramolecular steric factors. They propose quantifying these steric factors through the application of molecular mechanics models. The research involves close integration of theoretical and experimental chemistry. The experimental work entails synthesizing novel ligands and experimentally determining structures and binding constants for metal ion complexation by series of ligands in which architecture is systematically varied. The theoretical work entails using electronic structure calculations to parameterize a molecular mechanics force field for a range of metal ions and ligand types. The resulting molecular mechanics force field will be used to predict low energy structures for unidentate, bidentate, and multidentate ligands and their metal complexes through conformational searches. Results will be analyzed to assess the relative importance of several steric factors including optimal M-L length, optimal geometry at the metal center, optimal geometry at the donor atoms (complementarity), and conformation prior to binding (preorganization). An accurate set of criteria for the design of ligand architecture will be obtained from these results. These criteria will enable researchers to target ligand structures for synthesis and thereby dramatically reduce the time and cost associated with metal-specific ligand development.'

  7. Architectural design criteria for f-block metal sequestering agents. 1997 annual progress report

    International Nuclear Information System (INIS)

    Hay, B.P.; Paine, R.T.; Roundhill, D.M.

    1997-01-01

    'The objective of this project is to provide the means to optimize ligand architecture for f-block metal recognition. The authors strategy builds on an innovative and successful molecular modeling approach in developing polyether ligand design criteria for the alkali and alkaline earth cations. The hypothesis underlying this proposal is that differences in metal ion binding with multidentate ligands bearing the same number and type of donor groups are primarily attributable to intramolecular steric factors. The authors propose quantifying these steric factors through the application of molecular mechanics models. The proposed research involves close integration of theoretical and experimental chemistry. The experimental work entails synthesizing novel ligands and experimentally determining structures and binding constants for metal ion complexation by series of ligands in which architecture is systematically varied. The theoretical work entails using electronic structure calculations to parameterize a molecular mechanics force field for a range of metal ions and ligand types. The resulting molecular mechanics force field will be used to predict low-energy structures for unidentate, bidentate, and multidentate ligands and their metal complexes through conformational searches. Results will be analyzed to assess the relative importance of several steric factors including optimal M-L length, optimal geometry at the metal center, optimal geometry at the donor atoms (complementarity), and conformation prior to binding (preorganization). An accurate set of criteria for the design of ligand architecture will be obtained from these results. These criteria will enable researchers to target ligand structures for synthesis and thereby dramatically reduce the time and cost associated with metal-specific ligand development.'

  8. Experimental design of a waste glass study

    International Nuclear Information System (INIS)

    Piepel, G.F.; Redgate, P.E.; Hrma, P.

    1995-04-01

    A Composition Variation Study (CVS) is being performed to support a future high-level waste glass plant at Hanford. A total of 147 glasses, covering a broad region of compositions melting at approximately 1150 degrees C, were tested in five statistically designed experimental phases. This paper focuses on the goals, strategies, and techniques used in designing the five phases. The overall strategy was to investigate glass compositions on the boundary and interior of an experimental region defined by single- component, multiple-component, and property constraints. Statistical optimal experimental design techniques were used to cover various subregions of the experimental region in each phase. Empirical mixture models for glass properties (as functions of glass composition) from previous phases wee used in designing subsequent CVS phases

  9. Progress in the conceptual design of the ITER cask and plug remote handling system

    Energy Technology Data Exchange (ETDEWEB)

    Locke, Darren, E-mail: darren.locke@f4e.europa.eu [Fusion for Energy Agency (F4E), Torres Diagonal Litoral B3, Josep Pla 2, 08019 Barcelona (Spain); González Gutiérrez, Carmen; Damiani, Carlo [Fusion for Energy Agency (F4E), Torres Diagonal Litoral B3, Josep Pla 2, 08019 Barcelona (Spain); Friconneau, Jean-Pierre; Martins, Jean-Pierre [ITER Organization, Route de Vinon sur Verdon, 13115 Saint Paul Lez Durance (France)

    2014-10-15

    Highlights: • The CPRHS is a complex system with a significant number of complicated interfaces. • Significant effort is being made to ensure that the system requirements are clearly defined. • This solution relates to planned operations and also anticipation of rescue operations. • With the CPRHS performing a safety function process control is being put in place. • All these factors will have a significant impact on the success of the CPRHS. - Abstract: One function of the ITER remote maintenance system is the transportation of in-vessel components and remote handling systems to and from the vacuum vessel and docking stations in the Hot Cell via dedicated galleries and lift. The cask and plug remote handling system (CPRHS) has been adopted as the solution to provide this nuclear confinement and transportation. This paper discusses the development of the conceptual design to-date and presents the processes being implemented to effectively control the subsequent CPRHS development. The CPRHS is a complex suite of systems with a significant number of interfaces with other ITER systems. Significant effort is being made to ensure that the system requirements are comprehensively defined and carefully managed and a feasible solution is developed – including planned and rescue operations. With the CPRHS performing a critical confinement function appropriate processes are being put in place to control the system development of the CPRHS. The expectation is that the combination of these factors will have a significant impact on the successful implementation of the CPRHS.

  10. Design, Fabrication, and Certification of Advanced Modular PV Power Systems Final Technical Progress Report

    International Nuclear Information System (INIS)

    Minyard, G.

    1998-01-01

    This report describes the overall accomplishments and benefits of Solar Electric Specialties Co. (SES) under this Photovoltaic Manufacturing Technology (PVMaT) subcontract. SES addressed design issues related to their modular autonomous PV power supply (MAPPS) and a mobile photogenset. MAPPS investigations included gel-cell batteries mounted horizontally; redisgn of the SES power supply; modified battery enclosure for increased safety and reduced cost; programmable, interactive battery charge controllers; and UL and FM listings. The photogenset systems incorporate generators, battery storage, and PV panels for a mobile power supply. The unit includes automatic oil-change systems for the propane generators, collapsible array mounts for the PV enclosure, and internal stowage of the arrays. Standardizing the products resulted in product lines of MAPPS and Photogensets that can be produced more economically and with shorter lead times, while increasing product quality and reliability. Product assembly and quality control have also been improved and streamlined with the development of standardized assembly processes and QC testing procedures. SES offers the UL-listed MAPPS at about the same price as its previous non-standardized, unlisted products

  11. Progress in the conceptual design of the ITER cask and plug remote handling system

    International Nuclear Information System (INIS)

    Locke, Darren; González Gutiérrez, Carmen; Damiani, Carlo; Friconneau, Jean-Pierre; Martins, Jean-Pierre

    2014-01-01

    Highlights: • The CPRHS is a complex system with a significant number of complicated interfaces. • Significant effort is being made to ensure that the system requirements are clearly defined. • This solution relates to planned operations and also anticipation of rescue operations. • With the CPRHS performing a safety function process control is being put in place. • All these factors will have a significant impact on the success of the CPRHS. - Abstract: One function of the ITER remote maintenance system is the transportation of in-vessel components and remote handling systems to and from the vacuum vessel and docking stations in the Hot Cell via dedicated galleries and lift. The cask and plug remote handling system (CPRHS) has been adopted as the solution to provide this nuclear confinement and transportation. This paper discusses the development of the conceptual design to-date and presents the processes being implemented to effectively control the subsequent CPRHS development. The CPRHS is a complex suite of systems with a significant number of interfaces with other ITER systems. Significant effort is being made to ensure that the system requirements are comprehensively defined and carefully managed and a feasible solution is developed – including planned and rescue operations. With the CPRHS performing a critical confinement function appropriate processes are being put in place to control the system development of the CPRHS. The expectation is that the combination of these factors will have a significant impact on the successful implementation of the CPRHS

  12. Design and development progress of a LLRF control system for a 500 MHz superconducting cavity

    Science.gov (United States)

    Lee, Y. S.; Kim, H. W.; Song, H. S.; Lee, J. H.; Park, K. H.; Yu, I. H.; Chai, J. S.

    2012-07-01

    The LLRF (low-level radio-frequency) control system which regulates the amplitude and the phase of the accelerating voltage inside a RF cavity is essential to ensure the stable operation of charged particle accelerators. Recent advances in digital signal processors and data acquisition systems have allowed the LLRF control system to be implemented in digitally and have made it possible to meet the higher demands associated with the performance of LLRF control systems, such as stability, accuracy, etc. For this reason, many accelerator laboratories have completed or are completing the developments of digital LLRF control systems. The digital LLRF control system has advantages related with flexibility and fast reconfiguration. This paper describes the design of the FPGA (field programmable gate array) based LLRF control system and the status of development for this system. The proposed LLRF control system includes an analog front-end, a digital board (ADC (analog to digital converter), DAC (digital to analog converter), FPGA, etc.) and a RF & clock generation system. The control algorithms will be implemented by using the VHDL (VHSIC (very high speed integrated circuits) hardware description language), and the EPICS (experiment physics and industrial control system) will be ported to the host computer for the communication. In addition, the purpose of this system is to control a 500 MHz RF cavity, so the system will be applied to the superconducting cavity to be installed in the PLS storage ring, and its performance will be tested.

  13. A comparative study of two shovel designs.

    Science.gov (United States)

    Degani, A; Asfour, S S; Waly, S M; Koshy, J G

    1993-10-01

    In the present study a modified shovel design with two perpendicular shafts is presented. This modified, two-shaft shovel was compared with a regular shovel. The modified shovel was evaluated and tested in a controlled laboratory environment using surface electromyography recorded from the lumbar paraspinal muscles. The new shovel design was also tested in a field study using ratings of perceived exertion. The results indicate that there was a significant reduction in EMG values of the lumbar paraspinal muscles and a consistent reduction in perceived exertion ratings while the modified shovel was being used for removing dirt in digging trenches up to 90 cm in depth.

  14. Design study on advanced nuclear fuel recycle system. Conceptual design study of recycle system using molten salt

    International Nuclear Information System (INIS)

    Kasai, Y.; Kakehi, I.; Moro, T.; Higashi, T.; Tobe, K.; Kawamura, F.; Yonezawa, S.; Yoshiuji, T.

    1998-10-01

    Advanced recycle system engineering group of OEC (Oarai Engineering Center) has being carried out a design study of the advanced nuclear fuel recycle system using molten salt (electro-metallurgical process). This system is aiming for improvements of fuel cycle economy and reduction of environmental burden (MA recycles, Minimum of radioactive waste disposal), and also improvement of safety and nuclear non-proliferation. This report describes results of the design study that has been continued since December 1996. (1) A design concept of the advanced nuclear fuel recycle system, that is a module type recycles system of pyrochemical reprocessing and fuel re-fabrication was studied. The module system has advantage in balance of Pu recycle where modules are constructed in coincidence with the construction plan of nuclear power plants, and also has flexibility for technology progress. A demonstration system, minimum size of the above module, was studies. This system has capacity of 10 tHM/y and is able to demonstrate recycle technology of MOX fuel, metal fuel and nitride fuel. (2) Each process of the system, which are pyrochemical electrorefining system, cathode processor, de-cladding system, waste disposal system, etc., were studied. In this study, capacity of an electrorefiner was discussed, and vitrification experiment of molten salt using lead-boric acid glass was conducted. (3) A hot cell system and material handling system of the demonstration system was studied. A robot driven by linear motor was studied for the handling system, and an arrangement plan of the cell system was made. Criticality analysis in the cell system and investigation of material accountancy system of the recycle plant were also made. This design study will be continued in coincidence with design study of reactor and fuel, aiming to establish the concept of FBR recycle system. (author)

  15. Accelerator research studies. Technical progress report, July 1, 1985-June 30, 1986

    International Nuclear Information System (INIS)

    1986-01-01

    Progress is reported in these areas: study of instabilities and emittance growth in periodic focusing systems for intense beams; study of collective ion acceleration by intense electron beams and pulse powered plasma focus; and study of microwave sources and parameter scaling for high-frequency linacs

  16. Accelerator research studies: Technical progress report, June 1, 1988--May 31, 1989

    International Nuclear Information System (INIS)

    1989-01-01

    This report discusses research progress in the following general topics: Study of transport and longitudinal compression of intense, high-brightness beams; study of collective ion acceleration by intense electron beams and pulse powered plasma focus; and study of microwave sources and parameter scaling for high-frequency electron-positron supercollider linacs

  17. JSFR design progress related to development of safety design criteria for generation IV sodium-cooled fast reactors. (4) Balance of plant

    International Nuclear Information System (INIS)

    Chikazawa, Yoshitaka; Katoh, Atsushi; Nabeshima, Kunihiko; Ohtaka, Masahiko; Uzawa, Masayuki; Ikari, Risako; Iwasaki, Mikinori

    2015-01-01

    In this paper, design study and evaluation related with safety design criteria (SDC) and safety design guideline (SDG) on the balance of plant (BOP) of the demonstration JSFR including fuel handling system, power supply system, component cooling water system, building arrangement are reported. For the fuel handling system, enhancement of storage cooling system has been investigated adding diversified cooling systems. For the power supply, existing emergency power supply system has been reinforced and alternative emergency power supply system is added. For the component cooling system, requirements and relation with safety grade components such investigated. Additionally for the component cooling system, design impact when adding decay heat removal system by sea water has been investigated. For reactor building, over view of evaluation on the external events and design policy for distributed arrangement is reported. Those design study and evaluation provides background information of SDC and SDG. (author)

  18. Progress in the design and construction of SPES at INFN-LNL

    International Nuclear Information System (INIS)

    Bisoffi, G.; Prete, G.; Andrighetto, A.; Andreev, V.; Bellan, L.; Bellato, M.; Bortolato, D.; Calderolla, M.; Canella, S.; Comunian, M.; Corradetti, S.; Fagotti, E.; Facco, A.; Favaron, P.; Ferrari, L.; Galatà, A.; Giacchini, M.; Gramegna, F.; Gulmini, M.; Lombardi, A.

    2016-01-01

    INFN-LNL is constructing an ISOL (Isotope Separation On Line) facility delivering neutron rich ion beams at 10 A MeV or beyond, making use of the linear accelerator ALPI as the secondary accelerator. The facility includes a direct ISOL target based on UC_x and able to reach 10"1"3 fissions/s. In parallel, an applied physics facility will be developed, with applications in medicine and neutron production. The SPES project is a national facility, approved and funded. Commissioning with the first exotic species is expected in 2019. The primary accelerator is a commercial cyclotron, which will send a 40 MeV, 200 μA proton beam onto an UC_x target, connected to SIS, PIS and LIS ion sources. The extracted beam is purified through a Low Resolution Mass Separator (LMRS, i.e. a Wien filter and a dispersive dipole), a beam cooler and a High Resolution Mass Separator (HRMS) and sent to an ECR charge breeder to boost the exotic beam charge state. The highly charged exotic beam is further separated in a MRMS (Medium Resolution Mass Separator) and injected into a 100% duty cycle RFQ and into the existing superconducting linac ALPI, which will be refurbished and upgraded to be an efficient exotic beam accelerator. The upgrade of ALPI will give ∼10 A MeV energy to "1"3"2Sn"1"9"+, taken as the reference ion beam. The paper presents the status of the design and construction of the SPES facility.

  19. Progress in engineering design of Indian LLCB TBM set for testing in ITER

    International Nuclear Information System (INIS)

    Chaudhuri, Paritosh; Ranjithkumar, S.; Sharma, Deepak; Danani, Chandan; Swami, H.L.; Bhattacharya, R.; Patel, Anita; Kumar, E. Rajendra; Vyas, K.N.

    2014-01-01

    Highlights: • The tritium breeding for LLCB TBM has been evaluated by neutronic analysis. • Details of thermal-hydraulic analyses performed for FW and internal components of LLCB TBM and shield block have been provided.. • The optimum dimensions of CB zones and Pb–Li flow have been selected to have the maximum temperatures of all components used to lie within their respective temperature window. • The design and thermal analysis of shield block and attachment system have been performed. - Abstract: The Indian Lead–Lithium Ceramic Breeder (LLCB) Test Blanket Module (TBM) is the Indian DEMO relevant blanket module, as a part of the TBM program in ITER. The LLCB TBM will be tested from the first phase of ITER operation in one-half of an ITER port no. 2. LLCB TBM-set consists of LLCB TBM module and shield block, which are attached with the help of attachment systems. This LLCB TBM set is inserted in a water-cooled stainless steel frame called ‘TBM frame’, which also provides the separation between the neighboring TBM-sets (Chinese TBM set) in port no. 2. In LLCB TBM, high-pressure helium gas is used to cool the first wall (FW) structure and lead–lithium eutectic (Pb–Li) flowing separately around the ceramic breeder (CB) pebble bed to cool the TBM internals which are heated due to the volumetric neutron heating during plasma operation. Low-pressure helium is purged inside the CB zones to extract the bred tritium. Thermal-structural analyses have been performed independently on LLCB TBM and shield block for TBM set using ANSYS. This paper will also describe the performance analysis of individual components of LLCB TBM set and their different configurations to optimize their performances

  20. Progress in the design and construction of SPES at INFN-LNL

    Energy Technology Data Exchange (ETDEWEB)

    Bisoffi, G.; Prete, G.; Andrighetto, A. [INFN-LNL, viale dell’Università 2, 35020 Legnaro (Padova) (Italy); Andreev, V. [ITEP, Bolshaya Cheremushkinskaya, 25, 117218 Moskva (Russian Federation); Bellan, L. [INFN-LNL, viale dell’Università 2, 35020 Legnaro (Padova) (Italy); Dipartimento di Fisica e Astronomia, Università degli Studi di Padova, Padova (Italy); Bellato, M. [INFN-Sezione di Padova, Via Marzolo, 8, 35131 Padova (Italy); Bortolato, D.; Calderolla, M.; Canella, S.; Comunian, M.; Corradetti, S.; Fagotti, E.; Facco, A.; Favaron, P. [INFN-LNL, viale dell’Università 2, 35020 Legnaro (Padova) (Italy); Ferrari, L. [INFN-Sezione di Padova, Via Marzolo, 8, 35131 Padova (Italy); Galatà, A.; Giacchini, M.; Gramegna, F.; Gulmini, M.; Lombardi, A. [INFN-LNL, viale dell’Università 2, 35020 Legnaro (Padova) (Italy); and others

    2016-06-01

    INFN-LNL is constructing an ISOL (Isotope Separation On Line) facility delivering neutron rich ion beams at 10 A MeV or beyond, making use of the linear accelerator ALPI as the secondary accelerator. The facility includes a direct ISOL target based on UC{sub x} and able to reach 10{sup 13} fissions/s. In parallel, an applied physics facility will be developed, with applications in medicine and neutron production. The SPES project is a national facility, approved and funded. Commissioning with the first exotic species is expected in 2019. The primary accelerator is a commercial cyclotron, which will send a 40 MeV, 200 μA proton beam onto an UC{sub x} target, connected to SIS, PIS and LIS ion sources. The extracted beam is purified through a Low Resolution Mass Separator (LMRS, i.e. a Wien filter and a dispersive dipole), a beam cooler and a High Resolution Mass Separator (HRMS) and sent to an ECR charge breeder to boost the exotic beam charge state. The highly charged exotic beam is further separated in a MRMS (Medium Resolution Mass Separator) and injected into a 100% duty cycle RFQ and into the existing superconducting linac ALPI, which will be refurbished and upgraded to be an efficient exotic beam accelerator. The upgrade of ALPI will give ∼10 A MeV energy to {sup 132}Sn{sup 19+}, taken as the reference ion beam. The paper presents the status of the design and construction of the SPES facility.

  1. Advanced light water reactor plants System 80+trademark design certification program. Annual progress report, October 1, 1994 - September 30, 1995

    International Nuclear Information System (INIS)

    1998-01-01

    The purpose of this report is to provide the status of the progress that was made towards Design Certification of System 80+trademark during the US government's 1995 fiscal year. The System 80+ Advanced Light Water Reactor (ALWR) is a 3931 MW (1350 MWe) Pressurized Water Reactor (PWR). The design covers an essentially complete plant. It is based on EPRI ALWR Utility Requirements Document (URD) improvements to the Standardized System 80 Nuclear Steam Supply System (NSSS) in operation at Palo Verde Units 1, 2, and 3. The NSSS is a traditional two-loop arrangement with two steam generators, two hot legs and four cold legs, each with a reactor coolant pump. The System 80+ standard design houses the NSSS in a spherical steel containment vessel which is enclosed in a concrete shield building, thus providing the safety advantages of a dual barrier to radioactivity release. Other major features include an all-digital, human-factors-engineered control room, an alternate electrical AC power source, an In-Containment Refueling Water Storage Tank (IRWST), and plant arrangements providing complete separation of redundant trains in safety systems

  2. Advanced light water reactor plants System 80+{trademark} design certification program. Annual progress report, October 1, 1994--September 30, 1995

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-09-01

    The purpose of this report is to provide the status of the progress that was made towards Design Certification of System 80+{trademark} during the US government`s 1995 fiscal year. The System 80+ Advanced Light Water Reactor (ALWR) is a 3931 MW (1350 MWe) Pressurized Water Reactor (PWR). The design covers an essentially complete plant. It is based on EPRI ALWR Utility Requirements Document (URD) improvements to the Standardized System 80 Nuclear Steam Supply System (NSSS) in operation at Palo Verde Units 1, 2, and 3. The NSSS is a traditional two-loop arrangement with two steam generators, two hot legs and four cold legs, each with a reactor coolant pump. The System 80+ standard design houses the NSSS in a spherical steel containment vessel which is enclosed in a concrete shield building, thus providing the safety advantages of a dual barrier to radioactivity release. Other major features include an all-digital, human-factors-engineered control room, an alternate electrical AC power source, an In-Containment Refueling Water Storage Tank (IRWST), and plant arrangements providing complete separation of redundant trains in safety systems.

  3. Advanced light water reactor plants System 80+trademark design certification program. Annual progress report, October 1, 1995 - September 30, 1996

    International Nuclear Information System (INIS)

    1996-01-01

    The purpose of this report is to provide a status of the progress that was made towards Design Certification of System 80+trademark during the US government's 1996 fiscal year. The System 80+ Advanced Light Water Reactor (ALWR) is a 3931 MW (1350 MWe) Pressurized Water Reactor (PWR). The design covers an essentially complete plant. It is based on EPRI ALWR Utility Requirements Document (URD) improvements to the Standardized System 80 Nuclear Steam Supply System (NSSS) in operation at Palo Verde Units 1, 2 and 3. The NSSS is a traditional two-loop arrangement with two steam generators, two hot legs and four cold legs, each with a reactor coolant pump. The System 80+ standard design houses the NSSS in a spherical steel containment vessel which is enclosed in a concrete shield building, thus providing the safety advantages of a dual barrier to radioactivity release. Other major features include an all-digital, human-factors-engineered control room, an alternate electrical AC power source, an In-Containment Refueling Water Storage Tank (IRWST), and plant arrangements providing complete separation of redundant trains in safety systems

  4. Design and development of a continuously variable ratio transmission for an automotive vehicle. Phase IV. Quarterly progress report

    Energy Technology Data Exchange (ETDEWEB)

    None

    1978-05-31

    Progress in the design and development of a continuously variable ratio transmission for an automotive vehicle is reported. The Major automotive hydromechanical transmission development problem continues to be the reduction of hydrostatic noise and the project plan, therefore, concentrated on the new hydrostatic module. The potential for achieving acceptably low noise levels in the second generation hydromechanical transmission is to be assessed by comparing the noise levels of the hydrostatic modules for the first and second generation transmissions. A set of twelve test points was selected comprising of road load steady state and wide-open-throttle acceleration at 10, 20, 30, 40, 50 and 60 mph. The module operating conditions for the two transmissions at each of these twelve points were calculated. Baseline noise data was measured on the first generation module. The results are given testing of co-axial hydrostatic module for second generation hydromechanical transmission will be emphasized. (LCL)

  5. Planning ideology and geographic thought in the early twentieth century: Charles Whitnall's progressive era park designs for socialist Milwaukee.

    Science.gov (United States)

    Platt, Lorne A

    2010-01-01

    As Milwaukee’s chief park planner in the early to mid-twentieth century, Charles Whitnall responded to the various underlying ideologies of the period within which he worked. His preference for parks was a political and physical response to and remedy for the industrialized and heavily congested city he called home. By examining the Progressive Era discourse associated with planning, this article situates Whitnall’s work within the political, aesthetic, and environmental contexts of geographic thought that influenced his plans for Milwaukee. In promoting a physical awareness associated with the natural features of the region and responding to the sociopolitical framework of contemporaries such as Ebenezer Howard, Whitnall incorporated a sense of compassion within his planning. He responded to the preexisting beer gardens of Pabst and Schlitz, as well as Olmsted-designed park spaces, by advocating for decentralization as part of a broader socialist agenda that had swept through Milwaukee during the early 1900s.

  6. Core design and fuel management studies

    International Nuclear Information System (INIS)

    Min, Byung Joo; Chan, P.

    1997-06-01

    The design target for the CANDU 9 requires a 20% increase in electrical power output from an existing 480-channel CANDU core. Assuming a net electrical output of 861 MW(e) for a natural uranium fuelled Bruce-B/Darlington reactor in a warm water site, the net electrical output of the reference CANDU 9 reactor would be 1033 MW(e). This report documents the result of the physics studies for the design of the CANDU 9 480/SEU core. The results of the core design and fuel management studies of the CANDU 9 480/SEU reactor indicated that up to 1033 MW(e) output can be achieved in a 480-channel CANDU core by using SEU core can easily be maintained indefinitely using an automated refuelling program. Fuel performance evaluation based on the data of the 500 FPDs refuelling simulation concluded that SEU fuel failure is not expected. (author). 2 tabs., 38 figs., 5 refs

  7. Association between circulating vitamin K1 and coronary calcium progression in community-dwelling adults: the Multi-Ethnic Study of Atherosclerosis

    Science.gov (United States)

    While animal studies found vitamin K treatment reduced vascular calcification, human data are limited. Using a case-cohort design, we determined the association between vitamin K status and coronary artery calcium (CAC) progression in the Multi-ethnic Study of Atherosclerosis. Serum phylloquinone (v...

  8. Serum metabolomics of slow vs. rapid motor progression Parkinson's disease: a pilot study.

    Directory of Open Access Journals (Sweden)

    James R Roede

    Full Text Available Progression of Parkinson's disease (PD is highly variable, indicating that differences between slow and rapid progression forms could provide valuable information for improved early detection and management. Unfortunately, this represents a complex problem due to the heterogeneous nature of humans in regards to demographic characteristics, genetics, diet, environmental exposures and health behaviors. In this pilot study, we employed high resolution mass spectrometry-based metabolic profiling to investigate the metabolic signatures of slow versus rapidly progressing PD present in human serum. Archival serum samples from PD patients obtained within 3 years of disease onset were analyzed via dual chromatography-high resolution mass spectrometry, with data extraction by xMSanalyzer and used to predict rapid or slow motor progression of these patients during follow-up. Statistical analyses, such as false discovery rate analysis and partial least squares discriminant analysis, yielded a list of statistically significant metabolic features and further investigation revealed potential biomarkers. In particular, N8-acetyl spermidine was found to be significantly elevated in the rapid progressors compared to both control subjects and slow progressors. Our exploratory data indicate that a fast motor progression disease phenotype can be distinguished early in disease using high resolution mass spectrometry-based metabolic profiling and that altered polyamine metabolism may be a predictive marker of rapidly progressing PD.

  9. Serum metabolomics of slow vs. rapid motor progression Parkinson's disease: a pilot study.

    Science.gov (United States)

    Roede, James R; Uppal, Karan; Park, Youngja; Lee, Kichun; Tran, Vilinh; Walker, Douglas; Strobel, Frederick H; Rhodes, Shannon L; Ritz, Beate; Jones, Dean P

    2013-01-01

    Progression of Parkinson's disease (PD) is highly variable, indicating that differences between slow and rapid progression forms could provide valuable information for improved early detection and management. Unfortunately, this represents a complex problem due to the heterogeneous nature of humans in regards to demographic characteristics, genetics, diet, environmental exposures and health behaviors. In this pilot study, we employed high resolution mass spectrometry-based metabolic profiling to investigate the metabolic signatures of slow versus rapidly progressing PD present in human serum. Archival serum samples from PD patients obtained within 3 years of disease onset were analyzed via dual chromatography-high resolution mass spectrometry, with data extraction by xMSanalyzer and used to predict rapid or slow motor progression of these patients during follow-up. Statistical analyses, such as false discovery rate analysis and partial least squares discriminant analysis, yielded a list of statistically significant metabolic features and further investigation revealed potential biomarkers. In particular, N8-acetyl spermidine was found to be significantly elevated in the rapid progressors compared to both control subjects and slow progressors. Our exploratory data indicate that a fast motor progression disease phenotype can be distinguished early in disease using high resolution mass spectrometry-based metabolic profiling and that altered polyamine metabolism may be a predictive marker of rapidly progressing PD.

  10. Designs for mechanical circulatory support device studies.

    Science.gov (United States)

    Neaton, James D; Normand, Sharon-Lise; Gelijns, Annetine; Starling, Randall C; Mann, Douglas L; Konstam, Marvin A

    2007-02-01

    There is increased interest in mechanical circulatory support devices (MCSDs), such as implantable left ventricular assist devices (LVADs), as "destination" therapy for patients with advanced heart failure. Because patient availability to evaluate these devices is limited and randomized trials have been slow in enrolling patients, a workshop was convened to consider designs for MCSD development including alternatives to randomized trials. A workshop was jointly planned by the Heart Failure Society of America and the US Food and Drug Administration and was convened in March 2006. One of the panels was asked to review different designs for evaluating new MCSDs. Randomized trials have many advantages over studies with no controls or with nonrandomized concurrent or historical controls. These advantages include the elimination of bias in the assignment of treatments and the balancing, on average, of known and unknown baseline covariates that influence response. These advantages of randomization are particularly important for studies in which the treatments may not differ from one another by a large amount (eg, a head-to-head study of an approved LVAD with a new LVAD). However, researchers have found it difficult to recruit patients to randomized studies because the number of clinical sites that can carry out the studies is not large. Also, there is a reluctance to randomize patients when the control device is considered technologically inferior. Thus ways of improving the design of randomized trials were discussed, and the advantages and disadvantages of alternative designs were considered. The panel concluded that designs should include a randomized component. Randomized designs might be improved by allowing the control device to be chosen before randomization, by first conducting smaller vanguard studies, and by allowing crossovers in trials with optimal medical management controls. With use of data from completed trials, other databases, and registries, alternative

  11. A progress report of the Marshall Islands nationwide thyroid study: an international cooperative scientific study.

    Science.gov (United States)

    Takahashi, T; Simon, S L; Trott, K R; Fujimori, K; Nakashima, N; Arisawa, K; Schoemaker, M J

    1999-04-01

    The objective of this report is to present a summary of progress of the Marshall Islands Nationwide Thyroid Study. As well known, the US atomic weapons testing program in the Pacific was conducted primarily between 1946 and 1958 in the Marshall Islands. The nuclear tests resulted in radioactive contamination of a number of atolls and resulted in exposure of Marshallese to undefined levels before our study. Little information has been paid to health consequences among residents of the nearly twenty inhibited atolls except for some information about nodular thyroid disease which was reported on by an US group. In a cooperative agreement with the Government of the Marshall Islands, between 1993 and 1997 we studied the prevalence of both thyroid nodules and thyroid cancer among 4766 Marshallese potentially exposed to radioiodines from bomb test fallout. That group represents more than 65% of the population at risk. We diagnosed 45 thyroid cancers and 1398 benign thyroid nodules. In addition, 23 study participants had been operated on prior to our study for thyroid cancer. Presently, we are developing a database of information to estimate radiation doses and planning a statistical analysis to determine if a dose-response relationship exists. These data will be important for the health promotion of exposed people all over the world including Hiroshima, Nagasaki, Semipalatinsk, Chernobyl and other locations. A timely completion is important for purpose of assisting Marshallese as well as to add the global understanding of radiation induced thyroid cancer.

  12. A progress report of the Marshall Islands nationwide thyroid study. An international cooperative scientific study

    Energy Technology Data Exchange (ETDEWEB)

    Takahashi, Tatsuya; Arisawa, Kokichi [Nagasaki Univ. (Japan). School of Medicine; Simon, S.L.; Trott, K.R.; Fujimori, Keisei; Nakashima, Noriaki; Schoemaker, M.J.

    1999-04-01

    The objective of this report is to present a summary of progress of the Marshall Islands Nationwide Thyroid Study. As well known, the US atomic weapons testing program in the Pacific was conducted primarily between 1946 and 1958 in the Marshall Islands. The nuclear tests resulted in radioactive contamination of a number of atolls and resulted in exposure of Marshallese to undefined levels before our study. Little information has been paid to health consequences among residents of the nearly twenty inhibited atolls except for some information about nodular thyroid disease which was reported on by an US group. In a cooperative agreement with the Government of the Marshall Islands, between 1993 and 1997 we studied the prevalence of both thyroid nodules and thyroid cancer among 4766 Marshallese potentially exposed to radioiodines from bomb test fallout. That group represents more than 65% of the population at risk. We diagnosed 45 thyroid cancers and 1398 benign thyroid nodules. In addition, 23 study participants had been operated on prior to our study for thyroid cancer. Presently, we are developing a database of information to estimate radiation doses and planning a statistical analysis to determine if a dose-response relationship exists. These data will be important for the health promotion of exposed people all over the world including Hiroshima, Nagasaki, Semipalatinsk, Chernobyl and other locations. A timely completion is important for purpose of assisting Marshallese as well as to add the global understanding of radiation induced thyroid cancer. (author)

  13. A progress report of the Marshall Islands nationwide thyroid study. An international cooperative scientific study

    International Nuclear Information System (INIS)

    Takahashi, Tatsuya; Arisawa, Kokichi; Simon, S.L.; Trott, K.R.; Fujimori, Keisei; Nakashima, Noriaki; Schoemaker, M.J.

    1999-01-01

    The objective of this report is to present a summary of progress of the Marshall Islands Nationwide Thyroid Study. As well known, the US atomic weapons testing program in the Pacific was conducted primarily between 1946 and 1958 in the Marshall Islands. The nuclear tests resulted in radioactive contamination of a number of atolls and resulted in exposure of Marshallese to undefined levels before our study. Little information has been paid to health consequences among residents of the nearly twenty inhibited atolls except for some information about nodular thyroid disease which was reported on by an US group. In a cooperative agreement with the Government of the Marshall Islands, between 1993 and 1997 we studied the prevalence of both thyroid nodules and thyroid cancer among 4766 Marshallese potentially exposed to radioiodines from bomb test fallout. That group represents more than 65% of the population at risk. We diagnosed 45 thyroid cancers and 1398 benign thyroid nodules. In addition, 23 study participants had been operated on prior to our study for thyroid cancer. Presently, we are developing a database of information to estimate radiation doses and planning a statistical analysis to determine if a dose-response relationship exists. These data will be important for the health promotion of exposed people all over the world including Hiroshima, Nagasaki, Semipalatinsk, Chernobyl and other locations. A timely completion is important for purpose of assisting Marshallese as well as to add the global understanding of radiation induced thyroid cancer. (author)

  14. Recent progress on test evidence, standardization and design of protection for exterior openings

    Directory of Open Access Journals (Sweden)

    Strøm Ruth Astrid

    2016-01-01

    A number of different fire scenarios that elements in vented facades/constructions can be exposed to have been studied. New test standards have been developed for the last few years and are explained. Finally, this paper evaluate how different fire stop products perform in different fire scenarios and which test standards are applicable.

  15. Progress in modular-stellarator fusion-power-reactor conceptual designs

    International Nuclear Information System (INIS)

    Sviatoslavsky, I.N.; Van Sciver, S.W.; Kulcinski, G.L.

    1982-01-01

    Recent encouraging experimental results on stellarators/torsatrons/heliotrons (S/T/H) have revived interest in these concepts as possible fusion power reactors. The use of modular coils to generate the stellarator topology has added impetus to this renewed interest. Studies of the modular coil approach to stellarators by UW-Madison and Los Alamos National Laboratory are summarized in this paper

  16. Incorporating Structural Health Monitoring in the Design of Slip Formed Concrete Wind Turbine Towers - Progress Report

    DEFF Research Database (Denmark)

    Hovgaard, Mads Knude

    , the project combines many different engineering disciplines and thus the report displays a variety of content. The reliability theory ties the different disciplines together, and the focus is chosen on the dominant uncertainties of the modal damage detection as a consequence barrier (risk reduction...... by decision rule), as the initial studies in the project indicated this as an interesting and innovative approach...

  17. High performance fiber reinforced concrete : Progress in knowledge and design codes

    NARCIS (Netherlands)

    Walraven, J.C.

    2009-01-01

    High performance fiber reinforced concrete is developing quickly to a modern structural material with a high potential. As for instance testified by the recent symposium on HPFRC in Kassel, Germany (April 2008) the number of structural applications increases. At this moment studies are carried out

  18. Modular Stellarator Reactor conceptual design study

    International Nuclear Information System (INIS)

    Miller, R.L.; Bathke, C.G.

    1983-01-01

    A conceptual design study of the Modular Stellarator Reactor is summarized. The physics basis of the approach is elucidated with emphasis on magnetics performance optimization. Key engineering features of the fusion power core are described. Comparisons with an analogous continuous-helical-coil (torsatron) system are made as the basis of a technical and economic assessment

  19. Quiet engine program flight engine design study

    Science.gov (United States)

    Klapproth, J. F.; Neitzel, R. E.; Seeley, C. T.

    1974-01-01

    The results are presented of a preliminary flight engine design study based on the Quiet Engine Program high-bypass, low-noise turbofan engines. Engine configurations, weight, noise characteristics, and performance over a range of flight conditions typical of a subsonic transport aircraft were considered. High and low tip speed engines in various acoustically treated nacelle configurations were included.

  20. Modular stellarator reactor conceptual design study

    International Nuclear Information System (INIS)

    Miller, R.L.; Krakowski, R.A.; Bathke, C.G.

    1983-01-01

    A conceptual design study of the Modular Stellarator Reactor is summarized. The physics basis of the approach is elucidated with emphasis on magnetics performance optimization. Key engineering features of the fusion power core are described. Comparisons with an analogous continuous-helical-coil (torsatron) system are made as the basis of a technical and economic assessment

  1. Progress with Long-Range Beam-Beam Compensation Studies for High Luminosity LHC

    Energy Technology Data Exchange (ETDEWEB)

    Rossi, Adriana; et al.

    2017-05-01

    Long-range beam-beam (LRBB) interactions can be a source of emittance growth and beam losses in the LHC during physics and will become even more relevant with the smaller '* and higher bunch intensities foreseen for the High Luminosity LHC upgrade (HL-LHC), in particular if operated without crab cavities. Both beam losses and emittance growth could be mitigated by compensat-ing the non-linear LRBB kick with a correctly placed current carrying wire. Such a compensation scheme is currently being studied in the LHC through a demonstration test using current-bearing wires embedded into col-limator jaws, installed either side of the high luminosity interaction regions. For HL-LHC two options are considered, a current-bearing wire as for the demonstrator, or electron lenses, as the ideal distance between the particle beam and compensating current may be too small to allow the use of solid materials. This paper reports on the ongoing activities for both options, covering the progress of the wire-in-jaw collimators, the foreseen LRBB experiments at the LHC, and first considerations for the design of the electron lenses to ultimately replace material wires for HL-LHC.

  2. High doses of biotin in chronic progressive multiple sclerosis: a pilot study.

    Science.gov (United States)

    Sedel, Frédéric; Papeix, Caroline; Bellanger, Agnès; Touitou, Valérie; Lebrun-Frenay, Christine; Galanaud, Damien; Gout, Olivier; Lyon-Caen, Olivier; Tourbah, Ayman

    2015-03-01

    No drug has been found to have any impact on progressive multiple sclerosis (MS). Biotin is a vitamin acting as a coenzyme for carboxylases involved in key steps of energy metabolism and fatty acids synthesis. Among others, biotin activates acetylCoA carboxylase, a potentially rate-limiting enzyme in myelin synthesis. The aim of this pilot study is to assess the clinical efficacy and safety of high doses of biotin in patients suffering from progressive MS. Uncontrolled, non-blinded proof of concept study 23 consecutive patients with primary and secondary progressive MS originated from three different French MS reference centers were treated with high doses of biotin (100-300mg/day) from 2 to 36 months (mean=9.2 months). Judgement criteria varied according to clinical presentations and included quantitative and qualitative measures. In four patients with prominent visual impairment related to optic nerve injury, visual acuity improved significantly. Visual evoked potentials in two patients exhibited progressive reappearance of P100 waves, with normalization of latencies in one case. Proton magnetic resonance spectroscopy (H-MRS) in one case showed a progressive normalization of the Choline/Creatine ratio. One patient with left homonymous hemianopia kept on improving from 2 to 16 months following treatment׳s onset. Sixteen patients out of 18 (89%) with prominent spinal cord involvement were considered as improved as confirmed by blinded review of videotaped clinical examination in 9 cases. In all cases improvement was delayed from 2 to 8 months following treatment׳s onset. These preliminary data suggest that high doses of biotin might have an impact on disability and progression in progressive MS. Two double-blind placebo-controlled trials are on going. Copyright © 2015 The Authors. Published by Elsevier B.V. All rights reserved.

  3. Vitamin D and clinical disease progression in HIV infection: results from the EuroSIDA study

    DEFF Research Database (Denmark)

    Viard, Jean-Paul; Souberbielle, Jean-Claude; Kirk, Ole

    2011-01-01

    BACKGROUND:: We examined the association between vitamin D [25(OH)D] level and disease progression in HIV infection. METHODS:: Within the EuroSIDA study, 2000 persons were randomly selected for 25(OH)D measurement in stored plasma samples closest to study entry. 25(OH)D results were stratified...

  4. Academic and social integration and study progress in problem based learning

    NARCIS (Netherlands)

    S.E. Severiens (Sabine); H.G. Schmidt (Henk)

    2009-01-01

    textabstractThe present study explores the effects of problem-based learning (PBL) on social and academic integration and study progress. Three hundred and five first-year students from three different psychology curricula completed a questionnaire on social and academic integration. Effects of a

  5. Realizing a Progressive Pedagogy: A Comparative Case Study of Two Reggio Emilia Preschools in San Francisco

    Science.gov (United States)

    Abdelfattah, Marwa

    2015-01-01

    This study aims to uncover how a particular imported philosophy of early childhood education, Reggio Emilia, is implemented in the context of one public and one private preschool in San Francisco. The philosophy of Reggio Emilia is believed to be progressive and to be developmentally appropriate for children in early childhood. The study involved…

  6. Progression and regression of atherosclerosis in APOE3-Leiden transgenic mice : An immunohistochemical study

    NARCIS (Netherlands)

    Gijbels, M.J.J.; Cammen, M. van der; Laan, L.J.W. van der; Emeis, J.J.; Havekes, L.M.; Hofker, M.H.; Kraal, G.

    1999-01-01

    Apolipoprotein E3-Leiden (APOE3-Leiden) transgenic mice develop hyperlipidemia and are highly susceptible to diet-induced atherosclerosis. We have studied the progression and regression of atherosclerosis using immunohistochemistry. Female transgenic mice were fed a moderate fat diet to study

  7. Reaction studies of hot silicon and germanium radicals. Progress report, February 1, 1982-July 31, 1984

    International Nuclear Information System (INIS)

    Gaspar, P.P.

    1984-01-01

    The experimental approach toward attaining the goals of this research program is briefly outlined, and the progress made in the 1982 to 1984 period is reviewed in sections entitled: (1) Recoil atom experiments, (2) Studies of thermally and photochemically generated silicon and germanium radicals, and (3) Ion-molecule reaction studies

  8. Powersail High Power Propulsion System Design Study

    Science.gov (United States)

    Gulczinski, Frank S., III

    2000-11-01

    A desire by the United States Air Force to exploit the space environment has led to a need for increased on-orbit electrical power availability. To enable this, the Air Force Research Laboratory Space Vehicles Directorate (AFRL/ VS) is developing Powersail: a two-phased program to demonstrate high power (100 kW to 1 MW) capability in space using a deployable, flexible solar array connected to the host spacecraft using a slack umbilical. The first phase will be a proof-of-concept demonstration at 50 kW, followed by the second phase, an operational system at full power. In support of this program, the AFRL propulsion Directorate's Spacecraft Propulsion Branch (AFRL/PRS ) at Edwards AFB has commissioned a design study of the Powersail High Power Propulsion System. The purpose of this study, the results of which are summarized in this paper, is to perform mission and design trades to identify potential full-power applications (both near-Earth and interplanetary) and the corresponding propulsion system requirements and design. The design study shall farther identify a suitable low power demonstration flight that maximizes risk reduction for the fully operational system. This propulsion system is expected to be threefold: (1) primary propulsion for moving the entire vehicle, (2) a propulsion unit that maintains the solar array position relative to the host spacecraft, and (3) control propulsion for maintaining proper orientation for the flexible solar array.

  9. A Design Study for Standard Nanofluid Coolants

    International Nuclear Information System (INIS)

    Bang, In Cheol; Heo, Gyun Young

    2007-01-01

    The experimental data for nanofluids in thermal-fluid systems have shown that the new fluids promise to become advanced heat transfer fluids in terms of thermal performance. While enhancing thermal characteristics, the solid-liquid mixtures present an unavoidable disadvantage in terms of pumping cost for economic operation of thermal-fluid systems. In addition, there is a lack of agreement between experimental data provided in the literature. We can find that this issue of nanofluids resembles that of designing new materials. Many nanofluids researchers tend to view the nanofluid field as a highly coupled 'tetrahedro' whose four vertices (performance, properties, structure, and processes) are interconnected to each other. The present design study has a big merit to systemize the nanofluid work and to reduce a lot of trial-error efforts. The present work found that there would be no comprehensible design strategy in developing nanofluids. In this work, the Axiomatic Design (AD) theory is applied to standardize the design of nanofluids in order to bring its practical use forward. According to the Independence Axiom of the AD theory, the excessive couplings between the functional requirements and the parameters of a nanofluid system prevent from meeting the functional goals of the entire system. At a parametric level, the design of a nanofluid system is inherently coupled due to the characteristics of thermal-fluid system; the design parameters physically affect each other sharing sub-level parameters for nanoparticles with making a feedback loop. Even though parts of the nanofluids are naturally coupled, it is possible to reduce and/or eliminate the degree of coupling by help of AD principles. From the perspective of AD, this implies that we are able to ascertain which nanofluid system is better one in the light of functional achievement

  10. RF quadrupole beam dynamics design studies

    International Nuclear Information System (INIS)

    Crandall, K.R.; Stokes, R.H.; Wangler, T.P.

    1979-01-01

    The radio-frequency quadrupole (RFQ) linear accelerator structure is expected to permit considerable flexibility in achieving linac design objectives at low velocities. Calculational studies show that the RFQ can accept a high-current, low-velocity, dc beam, bunch it with high efficiency, and accelerate it to a velocity suitable for injection into a drift-tube linac. Although it is relatively easy to generate a satisfactory design for an RFQ linac for low beam currents, the space-charge effects produced by high currents dominate the design criteria. Methods have been developed to generate solutions that make suitable compromises between the effects of emittance growth, transmission efficiency, and overall structure length. Results are given for a test RFQ linac operating at 425 MHz

  11. Study on advanced structural design for commercialized fast breeder reactors

    International Nuclear Information System (INIS)

    Morishita, Masaki; Aoto, Kazumi; Kasahara, Naoto; Asayama, Tai

    2003-05-01

    Japan Nuclear Cycle Development Institute (JNC) and Japan Atomic Power Company (JAPC) launched joint research programs on structural design and three-dimensional seismic isolation technologies, as part of the supporting R and D activities for the feasibility studies on commercialized fast breeder reactor cycle systems. A research project by JAPC under the auspices of the Ministry of Economy, Trade, and Industry (METI) with technical support by JNC is included in this joint study. This report contains the results of the research on the structural design technology. The research scope was identified as (1) FDS (FBR Design Standard), (2) Standardization of new material, and (3) System Based Code for Integrity, and the results of this year's studies are summarized as follows. (1) FDS (FBR Design Standard). R and D policy of Phase II study considering to the newest needs demanded for structural design were clarified, and R and D items were settled concretely. As for failure criteria, preliminary ratcheting-fatigue tests were conducted with rational methods, and Negligible Creep curves that settle creep designing region rationally were expanded their applying condition. R and D policy and items of guideline for inelastic analysis were clarified, and analyzing methodologies were studied. Summering up exemplification of thermal load prediction methodologies were progressed. To predict thermal striping loads, advanced frequency response function of thermal stress, and fatigue evaluation methodology were studied. (2) Standardization of new material. As for candidate 12-chromium stainless steel (added tungsten, non-added tungsten), that is expected to improve strength of components of commercialized FR, short and medium-term material tests, and creep-fatigue tests at small strain range were conducted. As for above candidate steel, TIG (Tungsten Inert Gas) welding method was recommended. Requirements to standardize new materials and index to select new materials were studied

  12. Progress towards a high-gain and robust target design for heavy ion fusion

    Energy Technology Data Exchange (ETDEWEB)

    Henestroza, Enrique; Grant Logan, B. [Lawrence Berkeley National Laboratory, Berkeley, California 94720 (United States)

    2012-07-15

    Recently [E. Henestroza et al., Phys. Plasmas 18, 032702 (2011)], a new inertial-fusion target configuration, the X-target, using one-sided axial illumination has been explored. This class of target uses annular and solid-profile heavy ion beams to compress and ignite deuterium-tritium (DT) fuel that fills the interior of metal cases that have side-view cross sections in the shape of an 'X.' X-targets using all-DT-filled metal cases imploded by three annular ion beams resulted in fuel densities of {approx}50 g/cm{sup 3} at peak compression, and fusion gains of {approx}50, comparable to heavy ion driven hohlraum targets [D. A. Callahan-Miller and M. Tabak, Phys. Plasmas 7, 2083 (2000)]. This paper discusses updated X-target configurations that incorporate inside the case a propellant (plastic) and a pusher (aluminum) surrounding the DT fuel. The updated configurations are capable of assembling higher fuel areal densities {approx}2 g/cm{sup 2} using two annular beams to implode the target to peak DT densities {approx}100 g/cm{sup 3}, followed by a fast-ignition solid ion beam which heats the high-density fuel to thermonuclear temperatures in {approx}200 ps to start the burn propagation, obtaining gains of {approx}300. These targets have been modeled using the radiation-hydrodynamics code HYDRA [M. M. Marinak et al., Phys. Plasmas 8, 2275 (2001)] in two- and three- dimensions to study the properties of the implosion as well as the ignition and burn propagation phases. At typical Eulerian mesh resolutions of a few microns, the aluminum-DT interface shows negligible Rayleigh-Taylor (RT) and Richtmyer-Meshkov instability growth; also, the shear flow of the DT fuel as it slides along the metal X-target walls, which drives the RT and Kelvin Helmholtz instabilities, does not have a major effect on the burning rate. An analytic estimate of the RT instability process at the Al-DT interface shows that the aluminum spikes generated during the pusher deceleration phase

  13. Editorial summary: findings from a survey on the Danish study progress reform

    DEFF Research Database (Denmark)

    Sarauw, Laura Louise; Madsen, Simon Ryberg

    The summary presents the key findings from the first comprehensive survey of what students expect of the Danish Study Progress Reform. The summarised report is based on a survey conducted among 4.354 university students, who were asked to assess how they expect to manage their time and prioritise...... their activities in light of the Study Progress Reform’s requirements for faster completion. The survey was distributed in April 2015 as part of a politically independent research project funded by the Danish Council for Independent Research/Humanities (FKK)....

  14. Thermodynamic Studies for Drug Design and Screening

    Science.gov (United States)

    Garbett, Nichola C.; Chaires, Jonathan B.

    2012-01-01

    Introduction A key part of drug design and development is the optimization of molecular interactions between an engineered drug candidate and its binding target. Thermodynamic characterization provides information about the balance of energetic forces driving binding interactions and is essential for understanding and optimizing molecular interactions. Areas covered This review discusses the information that can be obtained from thermodynamic measurements and how this can be applied to the drug development process. Current approaches for the measurement and optimization of thermodynamic parameters are presented, specifically higher throughput and calorimetric methods. Relevant literature for this review was identified in part by bibliographic searches for the period 2004 – 2011 using the Science Citation Index and PUBMED and the keywords listed below. Expert opinion The most effective drug design and development platform comes from an integrated process utilizing all available information from structural, thermodynamic and biological studies. Continuing evolution in our understanding of the energetic basis of molecular interactions and advances in thermodynamic methods for widespread application are essential to realize the goal of thermodynamically-driven drug design. Comprehensive thermodynamic evaluation is vital early in the drug development process to speed drug development towards an optimal energetic interaction profile while retaining good pharmacological properties. Practical thermodynamic approaches, such as enthalpic optimization, thermodynamic optimization plots and the enthalpic efficiency index, have now matured to provide proven utility in design process. Improved throughput in calorimetric methods remains essential for even greater integration of thermodynamics into drug design. PMID:22458502

  15. Thermodynamic studies for drug design and screening.

    Science.gov (United States)

    Garbett, Nichola C; Chaires, Jonathan B

    2012-04-01

    A key part of drug design and development is the optimization of molecular interactions between an engineered drug candidate and its binding target. Thermodynamic characterization provides information about the balance of energetic forces driving binding interactions and is essential for understanding and optimizing molecular interactions. This review discusses the information that can be obtained from thermodynamic measurements and how this can be applied to the drug development process. Current approaches for the measurement and optimization of thermodynamic parameters are presented, specifically higher throughput and calorimetric methods. Relevant literature for this review was identified in part by bibliographic searches for the period 2004 - 2011 using the Science Citation Index and PUBMED and the keywords listed below. The most effective drug design and development platform comes from an integrated process utilizing all available information from structural, thermodynamic and biological studies. Continuing evolution in our understanding of the energetic basis of molecular interactions and advances in thermodynamic methods for widespread application are essential to realize the goal of thermodynamically driven drug design. Comprehensive thermodynamic evaluation is vital early in the drug development process to speed drug development toward an optimal energetic interaction profile while retaining good pharmacological properties. Practical thermodynamic approaches, such as enthalpic optimization, thermodynamic optimization plots and the enthalpic efficiency index, have now matured to provide proven utility in the design process. Improved throughput in calorimetric methods remains essential for even greater integration of thermodynamics into drug design. © 2012 Informa UK, Ltd.

  16. Design study on metal fuel FBR cores

    International Nuclear Information System (INIS)

    Yokoo, T.; Tanaka, Y.; Ogata, T.

    1991-01-01

    A design approach for metal fuel FBR core to maintain fuel integrity during transient events by limiting eutectic/liquid phase formation is proposed based on the current status of metallic fuel development. Its impact as the limitation on the core outlet temperature is assessed through its application to two of CRIEPI's core concepts, high linear power 1000 MWe homogeneous design and medium linear power 300 MWe radially heterogeneous design. SESAME/SALT code is used in this study to analyze steady state and transient fuel behavior. SE2-FA code is developed based on SUPERENERGY-2 and used to analyze core thermal-hydraulics with uncertainties. As the result, the core outlet temperatures of both designs are found to be limited to ≤500degC if it is required to prevent eutectic/liquid phase formation during operational transients in order to guarantee the fuel integrity. Additional assessment is made assuming an advanced limiting condition that allows small liquid phase formation based on the liquid phase penetration rate derived from existing experimental results. The result indicates possibility of raising core outlet temperature to ∼ 530degC. Also, it is found that core design technology improvements such as hot spot factors reduction can contribute to the core outlet temperature extension by 10 ∼ 20degC. (author)

  17. Electron gun design study for the IUCF beam cooling system

    International Nuclear Information System (INIS)

    Friesel, D.L.; Ellison, T.; Jones, W.P.

    1985-01-01

    The design of a low temperature electron beam cooling system for the Indiana University electron-cooled storage ring is in progress. The storage ring, which will accept the light ion beams from the existing k=200, multi-stage cyclotron facility, requires an electron beam variable in energy from about 7 to 275 keV. The electron beam system consists of a high perveance electron gun with Pierce geometry and a flat cathode. The gun and a 28 element accelerating column are immersed in a uniform longitudinal magnetic guide field. A computer modeling study of the system was conducted to determine electron beam density and transverse temperature variations as a function of anode region and accelerator column design parameters. Transverse electron beam temperatures (E /SUB t/ = mc 2 β 2 γ(/theta/ /SUB H/ +/theta/ /SUB v/ )) of less than a few tenths of an electron volt at a maximum current density of 0.4 A/cm 2 are desired over the full energy range. This was achieved in the calculations without the use of resonant focusing for a 2 Amp, 275 keV electron beam. Some systematics of the electron beam temperature variations with system design parameters are presented. A short discussion of the mechanical design of the proposed electron beam system is also given

  18. Thermal Hydraulic design parameters study for severe accidents using neural networks

    Energy Technology Data Exchange (ETDEWEB)

    Roh, Chang Hyun; Chang, Soon Heung [Korea Advanced Institute of Science and Technology, Taejon (Korea, Republic of); Chang, Keun Sun [Sunmoon University, Asan (Korea, Republic of)

    1997-12-31

    To provide the information on severe accident progression is very important for advanced or new type of nuclear power plant (NPP) design. A parametric study, therefore, was performed to investigate the effect of thermal hydraulic design parameters on severe accident progression of pressurized water reactors (PWRs). Nine parameters, which are considered important in NPP design or severe accident progression, were selected among the various thermal hydraulic design parameters. The backpropagation neural network (BPN) was used to determine parameters, which might more strongly affect the severe accident progression, among nine parameters. For training, different input patterns were generated by the latin hypercube sampling (LHS) technique and then different target patterns that contain core uncovery time and vessel failure time were obtained for Young Gwang Nuclear (YGN) Units 3 and 4 using modular accident analysis program (MAAP) 3.0B code. Three different severe accident scenarios, such as two loss of coolant accidents (LOCAs) and station blackout (SBO), were considered in this analysis. Results indicated that design parameters related to refueling water storage tank (RWST), accumulator and steam generator (S/G) have more dominant effects on the progression of severe accidents investigated, compared to the other six parameters. 9 refs., 5 tabs. (Author)

  19. Thermal Hydraulic design parameters study for severe accidents using neural networks

    Energy Technology Data Exchange (ETDEWEB)

    Roh, Chang Hyun; Chang, Soon Heung [Korea Advanced Institute of Science and Technology, Taejon (Korea, Republic of); Chang, Keun Sun [Sunmoon University, Asan (Korea, Republic of)

    1998-12-31

    To provide the information on severe accident progression is very important for advanced or new type of nuclear power plant (NPP) design. A parametric study, therefore, was performed to investigate the effect of thermal hydraulic design parameters on severe accident progression of pressurized water reactors (PWRs). Nine parameters, which are considered important in NPP design or severe accident progression, were selected among the various thermal hydraulic design parameters. The backpropagation neural network (BPN) was used to determine parameters, which might more strongly affect the severe accident progression, among nine parameters. For training, different input patterns were generated by the latin hypercube sampling (LHS) technique and then different target patterns that contain core uncovery time and vessel failure time were obtained for Young Gwang Nuclear (YGN) Units 3 and 4 using modular accident analysis program (MAAP) 3.0B code. Three different severe accident scenarios, such as two loss of coolant accidents (LOCAs) and station blackout (SBO), were considered in this analysis. Results indicated that design parameters related to refueling water storage tank (RWST), accumulator and steam generator (S/G) have more dominant effects on the progression of severe accidents investigated, compared to the other six parameters. 9 refs., 5 tabs. (Author)

  20. Design and implementation progress of multi-purpose simulator for nuclear research reactor using LabVIEW

    International Nuclear Information System (INIS)

    Arafa, Amany Abdel Aziz; Saleh, Hassan Ibrahim; Ashoub, Nagieb

    2015-01-01

    This paper illustrates the neutronic and thermal hydraulic models that were implemented in the nuclear research reactor simulator based on LabVIEW. It also describes the system and transient analysis of the simulator that takes into consideration the temperature effects and poisoning. This simulator is designed to be a multi-purpose in which the operator could understand the effects of the input parameters on the reactor. A designer can study different solutions for virtual reactor accident scenarios. The main features of the simulator are the flexibility to design and maintain the interface and the ability to redesign and remodel the reactor core engine. The developed reactor simulator permits to acquire hands-on the experience of the physics and technology of nuclear reactors including reactivity control, thermodynamics, technology design and safety system design. This simulator can be easily customizable and upgradable and new opportunities for collaboration between academic groups could be conducted.

  1. Design and implementation progress of multi-purpose simulator for nuclear research reactor using LabVIEW

    Energy Technology Data Exchange (ETDEWEB)

    Arafa, Amany Abdel Aziz; Saleh, Hassan Ibrahim [Atomic Energy Authority, Cairo (Egypt). Radiation Engineering Dept.; Ashoub, Nagieb [Atomic Energy Authority, Cairo (Egypt). Nuclear Research Center

    2015-11-15

    This paper illustrates the neutronic and thermal hydraulic models that were implemented in the nuclear research reactor simulator based on LabVIEW. It also describes the system and transient analysis of the simulator that takes into consideration the temperature effects and poisoning. This simulator is designed to be a multi-purpose in which the operator could understand the effects of the input parameters on the reactor. A designer can study different solutions for virtual reactor accident scenarios. The main features of the simulator are the flexibility to design and maintain the interface and the ability to redesign and remodel the reactor core engine. The developed reactor simulator permits to acquire hands-on the experience of the physics and technology of nuclear reactors including reactivity control, thermodynamics, technology design and safety system design. This simulator can be easily customizable and upgradable and new opportunities for collaboration between academic groups could be conducted.

  2. Design study on divertor plates of Large Helical Device (LHD)

    International Nuclear Information System (INIS)

    Noda, N.; Kubota, Y.; Sagara, A.

    1992-10-01

    A conceptual design has been completed for the divertor plates of the Large Helical Device (LHD, R = 3.9 m, a p = 50 ∼ 60 cm, B h = 3 ∼ 4T/ superconducting coils of NbTi) and the detailed technical design is now in progress. The design concept and the status of research and development (R and D) programs are described. (author)

  3. Progression of Stargardt Disease as Determined by Fundus Autofluorescence in the Retrospective Progression of Stargardt Disease Study (ProgStar Report No. 9).

    Science.gov (United States)

    Strauss, Rupert W; Muñoz, Beatriz; Ho, Alexander; Jha, Anamika; Michaelides, Michel; Cideciyan, Artur V; Audo, Isabelle; Birch, David G; Hariri, Amir H; Nittala, Muneeswar G; Sadda, SriniVas; West, Sheila; Scholl, Hendrik P N

    2017-11-01

    Sensitive outcome measures for disease progression are needed for treatment trials of Stargardt disease. To describe the yearly progression rate of atrophic lesions in the retrospective Progression of Stargardt Disease study. A multicenter retrospective cohort study was conducted at tertiary referral centers in the United States and Europe. A total of 251 patients aged 6 years or older at baseline, harboring disease-causing variants in ABCA4 (OMIM 601691), enrolled in the study from 9 centers between August 2, 2013, and December 12, 2014; of these patients, 215 had at least 2 gradable fundus autofluorescence images with atrophic lesion(s) present in at least 1 eye. Areas of definitely decreased autofluorescence (DDAF) and questionably decreased autofluorescence were quantified by a reading center. Progression rates were estimated from linear mixed models with time as the independent variable. Yearly rate of progression using the growth of atrophic lesions measured by fundus autofluorescence. A total of 251 participants (458 study eyes) were enrolled. Images from 386 eyes of 215 participants (126 females and 89 males; mean [SD] age, 29.9 [14.7] years; mean [SD] age of onset of symptoms, 21.9 [13.3] years) showed atrophic lesions present on at least 2 visits and were graded for 2 (156 eyes), 3 (174 eyes), or 4 (57 eyes) visits. A subset of 224 eyes (123 female participants and 101 male participants; mean [SD] age, 33.0 [15.1] years) had areas of DDAF present on at least 2 visits; these eyes were included in the estimation of the progression of the area of DDAF. At the first visit, DDAF was present in 224 eyes (58.0%), with a mean (SD) lesion size of 2.2 (2.7) mm2. The total mean (SD) area of decreased autofluorescence (DDAF and questionably decreased autofluorescence) at first visit was 2.6 (2.8) mm2. Mean progression of DDAF was 0.51 mm2/y (95% CI, 0.42-0.61 mm2/y), and of total decreased fundus autofluorescence was 0.35 mm2/y (95% CI, 0.28-0.43 mm2/y). Rates of

  4. Incidence and progression of aortic valve calcium in the Multi-ethnic Study of Atherosclerosis (MESA).

    Science.gov (United States)

    Owens, David S; Katz, Ronit; Takasu, Junichiro; Kronmal, Richard; Budoff, Matthew J; O'Brien, Kevin D

    2010-03-01

    Aortic valve calcium (AVC) is common among older adults and shares epidemiologic and histopathologic similarities to atherosclerosis. However, prospective studies have failed to identify meaningful risk associations with incident ("new") AVC or its progression. In the present study, AVC was quantified from serial computed tomographic images from 5,880 participants (aged 45 to 84 years) in the Multi-Ethnic Study of Atherosclerosis, using the Agatston method. Multivariate backward selection modeling was used to identify the risk factors for incident AVC and AVC progression. During a mean follow-up of 2.4 +/- 0.9 years, 210 subjects (4.1%) developed incident AVC. The incidence rate (mean 1.7%/year) increased significantly with age (p AVC included age, male gender, body mass index, current smoking, and the use of lipid-lowering and antihypertensive medications. Among those with AVC at baseline, the median rate of AVC progression was 2 Agatston units/year (interquartile range -21 to 37). The baseline Agatston score was a strong, independent predictor of progression, especially among those with high calcium scores at baseline. In conclusion, in this ethnically diverse, preclinical cohort, the rate of incident AVC increased significantly with age. The incident AVC risk was associated with several traditional cardiovascular risk factors, specifically age, male gender, body mass index, current smoking, and the use of both antihypertensive and lipid-lowering medications. AVC progression risk was associated with male gender and the baseline Agatston score. Additional research is needed to determine whether age- and stage-specific mechanisms underlie the risk of AVC progression. Copyright 2010 Elsevier Inc. All rights reserved.

  5. The effect of conditional probability of chord progression on brain response: an MEG study.

    Directory of Open Access Journals (Sweden)

    Seung-Goo Kim

    Full Text Available BACKGROUND: Recent electrophysiological and neuroimaging studies have explored how and where musical syntax in Western music is processed in the human brain. An inappropriate chord progression elicits an event-related potential (ERP component called an early right anterior negativity (ERAN or simply an early anterior negativity (EAN in an early stage of processing the musical syntax. Though the possible underlying mechanism of the EAN is assumed to be probabilistic learning, the effect of the probability of chord progressions on the EAN response has not been previously explored explicitly. METHODOLOGY/PRINCIPAL FINDINGS: In the present study, the empirical conditional probabilities in a Western music corpus were employed as an approximation of the frequencies in previous exposure of participants. Three types of chord progression were presented to musicians and non-musicians in order to examine the correlation between the probability of chord progression and the neuromagnetic response using magnetoencephalography (MEG. Chord progressions were found to elicit early responses in a negatively correlating fashion with the conditional probability. Observed EANm (as a magnetic counterpart of the EAN component responses were consistent with the previously reported EAN responses in terms of latency and location. The effect of conditional probability interacted with the effect of musical training. In addition, the neural response also correlated with the behavioral measures in the non-musicians. CONCLUSIONS/SIGNIFICANCE: Our study is the first to reveal the correlation between the probability of chord progression and the corresponding neuromagnetic response. The current results suggest that the physiological response is a reflection of the probabilistic representations of the musical syntax. Moreover, the results indicate that the probabilistic representation is related to the musical training as well as the sensitivity of an individual.

  6. Parametric study for design of thermal sleeves

    International Nuclear Information System (INIS)

    Mukherjee, A.B.; Mehra, V.K.

    1985-01-01

    Thermal sleeves are used inside nozzle in many reactor components. Basic aim in design of thermal sleeve is to arrive at a set of dimensions for gap and annulus length, which will give rise to minimum thermal gradient in the base metal of the associated nozzle. Study includes the minimisation of the thermal gradient in the crotch zone by suitable choice of gap and annulus length. Three different geometries of nozzle radii 50.00 mm., 100 mm. and 200.0 mm. are studied for single and two concentric thermal sleeves model. The paper also presents effect of parameters like velocity of flow, temperature of fluid, materials etc. on the design of thermal sleeves. (orig.)

  7. DU-AGG pilot plant design study

    International Nuclear Information System (INIS)

    Lessing, P.A.; Gillman, H.

    1996-07-01

    The Idaho National Engineering Laboratory (INEL) is developing new methods to produce high-density aggregate (artificial rock) primarily consisting of depleted uranium oxide. The objective is to develop a low-cost method whereby uranium oxide powder (UO[sub 2], U[sub 3]O[sub ]8, or UO[sub 3]) can be processed to produce high-density aggregate pieces (DU-AGG) having physical properties suitable for disposal in low-level radioactive disposal facilities or for use as a component of high-density concrete used as shielding for radioactive materials. A commercial company, G-M Systems, conducted a design study for a manufacturing pilot plant to process DU-AGG. The results of that study are included and summarized in this report. Also explained are design considerations, equipment capacities, the equipment list, system operation, layout of equipment in the plant, cost estimates, and the proposed plan and schedule

  8. Progress in welding studies for Canadian nuclear fuel waste disposal containers

    International Nuclear Information System (INIS)

    Maak, P.Y.Y.

    1985-11-01

    This report describes the progress in the development of closure-welding technology for Canadian nuclear fuel waste disposal containers. Titanium, copper and Inconel 625 are being investigated as candidate materials for fabrication of these containers. Gas-tungsten-arc welding, gas metal-arc-welding, resistance-heated diffusion bonding and electron beam welding have been evaluated as candidate closure welding processes. Characteristic weldment properties, relative merits of welding techniques, suitable weld joint configurations and fit-up tolerances, and welding parameter control ranges have been identified for various container designs. Furthermore, the automation requirements for candidate welding processes have been assessed. Progress in the development of a computer-controlled remote gas-shielded arc welding system is described

  9. Basic studies of atomic dynamics. Progress report for period October 1, 1977--September 30, 1978

    International Nuclear Information System (INIS)

    Fano, U.

    1978-01-01

    Novel and unexpected progress was achieved this year on the interaction of an electron with a polar molecule, by introducing an adiabatic procedure of progressive frame transformation whose adiabatic channels are determined by solving a two-variable non-separable problem. This success and the requirements of other tasks have increased interest in unraveling the significance of approximations based on separability of variables and adiabaticity whose success keeps exceeding expectations. Efforts in this direction are just beginning. Promising progress has also been achieved in calculations of a pair of correlated electrons in the field of an ion rather than of a bare nucleus. This work centers on the states of K - . The theory of crystal electron states with point symmetry about an impurity has made further progress but it has reached now a stopping point still short of its ultimate goal. The study of symmetries in atomic processes by tensorial methods has made much progress, thanks primarily to experimentalists interested in exploiting or refining their work. A list of reports is included

  10. Search for design intelligence: A field study on the role of emotional intelligence in architectural design studios

    Directory of Open Access Journals (Sweden)

    Sajjad Nazidizaji

    2014-12-01

    Full Text Available The design studio is the core of the architecture curriculum. Interpersonal interactions have a key role during the processes of design and critique. The influence of emotional intelligence (EQ on interpersonal communication skills has been widely proven. This study examines the correlation between EQ and architectural design competence. To achieve this, 78 architecture students were selected via a simple random sampling method and tested using an EQ test questionnaire developed by Bradbury and Greaves (2006. The scores of five architectural design studio courses (ADS-1, ADS-2, ADS-3, ADS-4, and ADS-5 were used as indicators of the progress in design of the students. Descriptive and inferential statistics methods were both employed to analyze the research data. The methods included correlation analysis, mean comparison t-test for independent samples, and single sample t-test. Findings showed no significant relationship between EQ and any of the indicators.

  11. Design studies for the Positron Factory

    International Nuclear Information System (INIS)

    Okada, S.; Sunaga, H.; Kaneko, H.; Masuno, S.; Kawasuso, A.; Sakai, T.; Takizawa, H.; Yotsumoto, K.; Honda, Y.; Tagawa, S.

    1996-01-01

    In the design study for the Positron Factory, a feasibility of simultaneous extraction of multi-channel monoenergetic positron beams, which had been proposed at the previous conference (Linac 94), was demonstrated by an experiment using an electron linac. On the basis of the experimental result, an efficient moderator structure, which is composed of honeycomb-like assembled moderator foils and reflectors, is proposed. (author)

  12. Nuclear structure studies by the scattering of medium-energy electrons. Progress report, October 1, 1980-July 31, 1981

    International Nuclear Information System (INIS)

    Peterson, G.A.

    1981-08-01

    Electron scattering experiments are in progress at the Bates Linear Accelerator in Middleton, Massachusetts. Both magnetic elastic and transverse inelastic scattering cross sections have been measured at 180 0 by the apparatus constructed and brought into operation in late 1977 by the University of Massachusetts. A liquid-nitrogen-cooled gas target is being used in a study of deuteron elastic magnetic scattering and electrodisintegration over a large energy range. A measurement of elastic magnetic and transverse inelastic scattering from 14 N has been started. Measurements of the elastic magnetic scattering from 13 C, 15 N, 27 Al, 29 Si, and 31 P have been completed. The data set on 15 N inelastic scattering are now complete and analysis of the data is in progress. A study of M8 transitions in 54 Fe and 60 Ni is nearing completion. Several papers are being written on these subjects. A measurement of the transverse quasi-elastic scattering from 56 Fe has been started. Planning for an experiment utilizing radioactive 14 C is underway. Large-basis shell model calculations pertaining to the above nuclei and others have been made. Theoretical calculations of exchange currents, nuclear convection currents, and other nuclear phenomena are in progress. Finally, considerations are being given to the design of an integrated storage-ring-experimental system

  13. Nuclear-structure studies by the scattering of medium-energy electrons. Progress report, October 1, 1980-July 31, 1981

    International Nuclear Information System (INIS)

    Peterson, G.A.

    1981-08-01

    Electron scattering experiments are in progress at the Bates Linear Accelerator in Middleton, Massachusetts. Both magnetic elastic and transverse inelastic scattering cross sections have been measured at 180 0 by the apparatus constructed and brought into operation in late 1977 by the University of Massachusetts. A liquid-nitrogen-cooled gas target is being used in a study of deuteron elastic scattering and electrodisintegration over a large energy range. A measurement of elastic magnetic and transverse inelastic scattering from 14 N has been started. Measurements of the elastic magnetic scattering from 13 C, 15 N, 27 Al, 29 Si, and 31 P have been completed. The data set on 15 N inelastic scattering are now complete and analysis of the data is in progress. A study of M8 transitions in 54 Fe and 60 Ni is nearing completion. A measurement of the transverse quasielastic scattering from 56 Fe has been started. Planning for an experiment utilizing radioactive 14 C is underway. Large-basis shell model calculations pertaining to the above nuclei and others have been made. Theoretical calculations of exchange currents, nuclear convection currents, and other nuclear phenomena are in progress. Finally, considerations are being given to the design of an integrated storage-ring-experimental system

  14. Progressive apraxia of speech as a window into the study of speech planning processes.

    Science.gov (United States)

    Laganaro, Marina; Croisier, Michèle; Bagou, Odile; Assal, Frédéric

    2012-09-01

    We present a 3-year follow-up study of a patient with progressive apraxia of speech (PAoS), aimed at investigating whether the theoretical organization of phonetic encoding is reflected in the progressive disruption of speech. As decreased speech rate was the most striking pattern of disruption during the first 2 years, durational analyses were carried out longitudinally on syllables excised from spontaneous, repetition and reading speech samples. The crucial result of the present study is the demonstration of an effect of syllable frequency on duration: the progressive disruption of articulation rate did not affect all syllables in the same way, but followed a gradient that was function of the frequency of use of syllable-sized motor programs. The combination of data from this case of PAoS with previous psycholinguistic and neurolinguistic data, points to a frequency organization of syllable-sized speech-motor plans. In this study we also illustrate how studying PAoS can be exploited in theoretical and clinical investigations of phonetic encoding as it represents a unique opportunity to investigate speech while it progressively disrupts. Copyright © 2011 Elsevier Srl. All rights reserved.

  15. The Somalia Country Case Study. Mid-Decade Review of Progress towards Education for All.

    Science.gov (United States)

    Bennaars, Gerard A.; Seif, Huda A.; Mwangi, Doris

    In 1995, the International Consultative Forum on Education for All commissioned case studies in developing countries as part of a mid-decade review of progress in expanding access to basic education. This paper examines the situation in Somalia, where civil war has completely destroyed the infrastructure of education. Part 1 summarizes Somalia's…

  16. Primary radiotherapy in progressive optic nerve sheath meningiomas: a long-term follow-up study

    NARCIS (Netherlands)

    Saeed, P.; Blank, L.; Selva, D.; Wolbers, J.G.; Nowak, P.J.C.M.; Geskus, R.B.; Weis, E.; Mourits, M.P.; Rootman, J.

    2010-01-01

    Background/aims To report the outcome of primary radiotherapy in patients with progressive optic nerve sheath meningioma (ONSM). Methods The clinical records of all patients were reviewed in a retrospective, observational, multicentre study. Results Thirty-four consecutive patients were included.

  17. Progress report on nuclear spectroscopic studies, June 1, 1977--May 31, 1978

    International Nuclear Information System (INIS)

    Bingham, C.R.; Riedinger, L.L.; Guidry, M.W.

    1978-01-01

    Research progress is summarized for activities of the University of Tennessee department of physics and astronomy in the following areas: (1) in-beam spectroscopy of high-spin state, (2) Coulomb-nuclear interference and inelastic heavy ion scattering (3) Coulomb excitation, nuclear theory, (4) nuclear structure studies with alpha-induced direct reactions, and (5) developmental activities

  18. Progress Report: Feasibility Study of an Indium Scintillator Solar Neutrino Experiment

    International Nuclear Information System (INIS)

    Bellefon, A. de; Barloutaud, R.; Borg, A.; Ernwein, J.; Mosca, L.

    1989-09-01

    In this document, we report on the progress made to demonstrate the feasibility of an experiment which would measure for the first time the two line sources of solar neutrinos resulting from electron capture by 7 Be and from the p-e-p reaction inside the sun. The detector under study consists of scintillator containing 10 tons of Indium

  19. Successful Career Progression: Exploratory Findings from a Study of Selected Occupations.

    Science.gov (United States)

    O'Shea, Daniel P.; Betsinger, Alicia M.; King, Christopher T.

    A study examined the career progression of individuals in the following occupations: registered nurse; physical therapist; medical laboratory technologist; paramedic; ranked corrections officer; dental hygienist; electronic technician; pipefitter/plumber; social worker; and auto body shop manager. Researchers conducted face-to-face interviews in…

  20. Stable isotope studies. Progress report, August 1, 1974--July 31, 1975

    International Nuclear Information System (INIS)

    Flynn, G.W.; Hsu, D.S.Y.; Preses, J.M.; Spindel, W.; Weston, R.E.

    1975-01-01

    Progress is reported in the following studies: selective two-step laser-induced photodissociation, unimolecular processes induced by multiple-photon absorption, and vibrational energy transfer processes involving isotopic species of sulfur dioxide. These laser-induced chemical reactions can possibly be applied to isotope separation

  1. Studies in theoretical high energy particle physics: Technical progress report [February 1987-February 1988

    International Nuclear Information System (INIS)

    Sukhatme, U.P.; Keung, Wai-Yee; Kovacs, E.

    1988-02-01

    This is a technical progress report for grant No. FG02-84ER40173 for the period February 1987 to February 1988. Our research on supersymmetric quantum mechanics has yielded many interesting results. In particular, a systematic approach to the tunneling problem in double well potentials has been developed. Higgs boson related physics at the high energy hadron colliders has been extensively studied

  2. Objective Cognitive Impairment and Progression to Dementia in Women: The Prospective Epidemiological Risk Factor Study

    DEFF Research Database (Denmark)

    Neergaard, Jesper; Dragsbæk, K.; Christiansen, C.

    2017-01-01

    Background: Identification of subjects with a progressive disease phenotype is an urgent need in the pharmaceutical industry where most of the recent clinical trials in Alzheimer’s disease have failed. Objectives: The objective of this study was to identify subgroups of individuals with objective...

  3. Development and applications of photosensitive device systems to studies of biological and organic materials. Progress report

    International Nuclear Information System (INIS)

    1984-01-01

    The purpose was to develop and improve appropriate experimental techniques to the point where they could be applied to specific classes of biological problems. Progress is reported in the following areas: (1) area detectors; (2) x-ray diffraction studies of membranes; (3) electron transfer in loosely coupled systems; (4) bioluminescence and fluorescence; and (5) sonoluminescence

  4. Periodontal Pocket Depth, Hyperglycemia, and Progression of Chronic Kidney Disease: A Population-Based Longitudinal Study.

    Science.gov (United States)

    Chang, Jia-Feng; Yeh, Jih-Chen; Chiu, Ya-Lin; Liou, Jian-Chiun; Hsiung, Jing-Ru; Tung, Tao-Hsin

    2017-01-01

    No large epidemiological study has been conducted to investigate the interaction and joint effects of periodontal pocket depth and hyperglycemia on progression of chronic kidney disease in patients with periodontal diseases. Periodontal pocket depth was utilized for the grading severity of periodontal disease in 2831 patients from January 2002 to June 2013. Progression of chronic kidney disease was defined as progression of color intensity in glomerular filtration rate and albuminuria grid of updated Kidney Disease-Improving Global Outcomes guidelines. Multivariable-adjusted hazard ratios (aHR) in various models were presented across different levels of periodontal pocket depth and hemoglobin A1c (HbA1c) in forest plots and 3-dimensional histograms. During 7621 person-years of follow-up, periodontal pocket depth and HbA1C levels were robustly associated with incremental risks for progression of chronic kidney disease (aHR 3.1; 95% confidence interval [CI], 2.0-4.6 for periodontal pocket depth >4.5 mm, and 2.5; 95% CI, 1.1-5.4 for HbA1C >6.5%, respectively). The interaction between periodontal pocket depth and HbA1C on progression of chronic kidney disease was strong (P periodontal pocket depth (>4.5 mm) and higher HbA1C (>6.5%) had the greatest risk (aHR 4.2; 95% CI, 1.7-6.8) compared with the lowest aHR group (periodontal pocket depth ≤3.8 mm and HbA1C ≤6%). Our study identified combined periodontal pocket depth and HbA1C as a valuable predictor of progression of chronic kidney disease in patients with periodontal diseases. While considering the interaction between periodontal diseases and hyperglycemia, periodontal survey and optimizing glycemic control are warranted to minimize the risk of worsening renal function. Copyright © 2016 Elsevier Inc. All rights reserved.

  5. Comparison of progressive addition lenses for general purpose and for computer vision: an office field study.

    Science.gov (United States)

    Jaschinski, Wolfgang; König, Mirjam; Mekontso, Tiofil M; Ohlendorf, Arne; Welscher, Monique

    2015-05-01

    Two types of progressive addition lenses (PALs) were compared in an office field study: 1. General purpose PALs with continuous clear vision between infinity and near reading distances and 2. Computer vision PALs with a wider zone of clear vision at the monitor and in near vision but no clear distance vision. Twenty-three presbyopic participants wore each type of lens for two weeks in a double-masked four-week quasi-experimental procedure that included an adaptation phase (Weeks 1 and 2) and a test phase (Weeks 3 and 4). Questionnaires on visual and musculoskeletal conditions as well as preferences regarding the type of lenses were administered. After eight more weeks of free use of the spectacles, the preferences were assessed again. The ergonomic conditions were analysed from photographs. Head inclination when looking at the monitor was significantly lower by 2.3 degrees with the computer vision PALs than with the general purpose PALs. Vision at the monitor was judged significantly better with computer PALs, while distance vision was judged better with general purpose PALs; however, the reported advantage of computer vision PALs differed in extent between participants. Accordingly, 61 per cent of the participants preferred the computer vision PALs, when asked without information about lens design. After full information about lens characteristics and additional eight weeks of free spectacle use, 44 per cent preferred the computer vision PALs. On average, computer vision PALs were rated significantly better with respect to vision at the monitor during the experimental part of the study. In the final forced-choice ratings, approximately half of the participants preferred either the computer vision PAL or the general purpose PAL. Individual factors seem to play a role in this preference and in the rated advantage of computer vision PALs. © 2015 The Authors. Clinical and Experimental Optometry © 2015 Optometry Australia.

  6. Is there a causal link between knee loading and knee osteoarthritis progression? A systematic review and meta-analysis of cohort studies and randomised trials

    Science.gov (United States)

    Henriksen, Marius; Creaby, Mark W; Lund, Hans; Juhl, Carsten; Christensen, Robin

    2014-01-01

    Objective We performed a systematic review, meta-analysis and assessed the evidence supporting a causal link between knee joint loading during walking and structural knee osteoarthritis (OA) progression. Design Systematic review, meta-analysis and application of Bradford Hill's considerations on causation. Data sources We searched MEDLINE, Scopus, AMED, CINAHL and SportsDiscus for prospective cohort studies and randomised controlled trials (RCTs) from 1950 through October 2013. Study eligibility criteria We selected cohort studies and RCTs in which estimates of knee joint loading during walking were used to predict structural knee OA progression assessed by X-ray or MRI. Data analyses Meta-analysis was performed to estimate the combined OR for structural disease progression with higher baseline loading. The likelihood of a causal link between knee joint loading and OA progression was assessed from cohort studies using the Bradford Hill guidelines to derive a 0–4 causation score based on four criteria and examined for confirmation in RCTs. Results Of the 1078 potentially eligible articles, 5 prospective cohort studies were included. The studies included a total of 452 patients relating joint loading to disease progression over 12–72 months. There were very serious limitations associated with the methodological quality of the included studies. The combined OR for disease progression was 1.90 (95% CI 0.85 to 4.25; I2=77%) for each one-unit increment in baseline knee loading. The combined causation score was 0, indicating no causal association between knee loading and knee OA progression. No RCTs were found to confirm or refute the findings from the cohort studies. Conclusions There is very limited and low-quality evidence to support for a causal link between knee joint loading during walking and structural progression of knee OA. Trial registration number CRD42012003253 PMID:25031196

  7. Quantitative studies in radiopharmaceutical science. Progress report, April 1-August 31, 1986

    International Nuclear Information System (INIS)

    Cooper, M.

    1986-09-01

    This report covers progress made during the first reporting period since the redirection of the project. In radiochemistry, achievements in fluorine-18 tracer studies including purification and reaction kinetics of 2-fluorodeoxyglucose and production of 6-fluoroDOPA. Radiopharmaceuticals have been prepared and tested for studies on CNS dopaminergic systems. By use of dynamic positron emission tomography the cerebral transport and metabolism of glucose continues to be studied. 6 figs

  8. Design Study for Pulsed Proton Beam Generation

    Directory of Open Access Journals (Sweden)

    Han-Sung Kim

    2016-02-01

    Full Text Available Fast neutrons with a broad energy spectrum, with which it is possible to evaluate nuclear data for various research fields such as medical applications and the development of fusion reactors, can be generated by irradiating proton beams on target materials such as beryllium. To generate short-pulse proton beam, we adopted a deflector and slit system. In a simple deflector with slit system, most of the proton beam is blocked by the slit, especially when the beam pulse width is short. Therefore, the available beam current is very low, which results in low neutron flux. In this study, we proposed beam modulation using a buncher cavity to increase the available beam current. The ideal field pattern for the buncher cavity is sawtooth. To make the field pattern similar to a sawtooth waveform, a multiharmonic buncher was adopted. The design process for the multiharmonic buncher includes a beam dynamics calculation and three-dimensional electromagnetic simulation. In addition to the system design for pulsed proton generation, a test bench with a microwave ion source is under preparation to test the performance of the system. The design study results concerning the pulsed proton beam generation and the test bench preparation with some preliminary test results are presented in this paper.

  9. Quantitative methods for studying design protocols

    CERN Document Server

    Kan, Jeff WT

    2017-01-01

    This book is aimed at researchers and students who would like to engage in and deepen their understanding of design cognition research. The book presents new approaches for analyzing design thinking and proposes methods of measuring design processes. These methods seek to quantify design issues and design processes that are defined based on notions from the Function-Behavior-Structure (FBS) design ontology and from linkography. A linkograph is a network of linked design moves or segments. FBS ontology concepts have been used in both design theory and design thinking research and have yielded numerous results. Linkography is one of the most influential and elegant design cognition research methods. In this book Kan and Gero provide novel and state-of-the-art methods of analyzing design protocols that offer insights into design cognition by integrating segmentation with linkography by assigning FBS-based codes to design moves or segments and treating links as FBS transformation processes. They propose and test ...

  10. Theoretical studies in hadronic and nuclear physics. Progress report, December 1, 1993--June 30, 1994

    International Nuclear Information System (INIS)

    Cohen, T.D.; Banerjee, M.K.

    1994-07-01

    Under Hadrons in Nuclei and Nuclear Matter the authors research the ways in which the properties of nucleons and mesons are modified in the nuclear medium. Research progress is reported on a number of topics in this general area, including studies of the role of chiral symmetry for finite density or temperature nuclear matter, the use of QCD sum rules to describe baryons in nuclear matter, and color transparency. In the general field of Hadron Physics broad progress included studies of perturbative QCD, heavy quark physics, QCD sum rules, and QCD-based models. Notable progress was also achieved in Relativistic Dynamics in Quark, Hadron, and Nuclear Physics, where an explicit model of composite particles shows how the z-graph physics (which is an essential part of Dirac phenomenology) comes about. In addition, calculations of elastic electron-deuteron scattering based on two-body relativistic dynamics and meson exchange currents were completed, as were studies of quark-anti-quark bound states based on a relativistic quark model. Progress is also reported on the relativistic few-body problem. In the area of Heavy Ion Dynamics and Sharp Lepton Pairs, work continues on the Composite Particle Scenario for the 'Sharp Lepton Problem'. In particular, the scenario can now encompass the anomalous sharp leptons reported from positron irradiation of heavy neutral atoms, establishing such irradiations as an alternative experimental window to the heavy ion experiments

  11. Undergraduate Use of Library Databases Decreases as Level of Study Progresses

    Directory of Open Access Journals (Sweden)

    Kimberly Miller

    2014-09-01

    Full Text Available A Review of: Mbabu, L.G., Bertram, A. B., & Varnum, K. (2013. Patterns of undergraduates’ use of scholarly databases in a large research university. Journal of Academic Librarianship, 39(2, 189-193. http://dx.doi.org/10.10.1016/j.acalib.2012.10.004 Abstract Objective – To investigate undergraduate students’ patterns of electronic database use to discover whether database use increases as undergraduate students progress into later stages of study with increasingly sophisticated information needs and demands. Design – User database authentication log analysis. Setting – A large research university in the Midwestern United States of America. Subjects – A total of 26,208 undergraduate students enrolled during the Fall 2009 academic semester. Methods – The researchers obtained logs of user-authenticated activity from the university’s databases. Logged data for each user included: the user’s action and details of that action (including database searches, the time of action, the user’s relationship to the university, the individual school in which the user was enrolled, and the user’s class standing. The data were analyzed to determine which proportion of undergraduate students accessed the library’s electronic databases. The study reports that the logged data accounted for 61% of all database activity, and the authors suggest the other 39% of use is likely from “non-undergraduate members of the research community within the [university’s] campus IP range” (192. Main Results – The study found that 10,897 (42% of the subject population of undergraduate students accessed the library’s electronic databases. The study also compared database access by class standing, and found that freshman undergraduates had the highest proportion of database use, with 56% of enrolled freshman accessing the library’s databases. Sophomores had the second highest proportion of students accessing the databases at 40%; juniors and seniors

  12. Interim report on the tandem mirror hybrid design study

    International Nuclear Information System (INIS)

    Moir, R.W.

    1979-01-01

    The initial phase of a 2-year design study of a tandem mirror fusion reactor is presented. The following chapters are included: (1) mechanical design of the plant; (2) plasma physics; (3) blanket design; (4) magnet design; (5) injector design; (6) direct convertor design; (7) balance of plant design; (8) fission burner reactor; (9) environment and safety; and (10) economic analysis

  13. Design and analysis of biomedical studies

    DEFF Research Database (Denmark)

    Hansen, Merete Kjær

    been allocated this field. It is utterly important to utilize these ressources responsibly and efficiently by constantly striving to ensure high-quality biomedical studies. This involves the use of a sound statistical methodology regarding both the design and analysis of biomedical studies. The focus...... have conducted a literature study strongly indicating that this structure commonly is neglected in the statistical analysis. Based on this closed-form expressions for the approximate type I error rate are formulated. The type I error rates are assessed for a number of factor combinations as they appear...... in practice and in all cases the type I error rates are demonstrated to be severely inflated. Prior to conducting a study it is important to perform power and sample size determinations to ensure that reliable conclusions can be drawn from the statistical analysis. We have formulated closed-form expressions...

  14. Influence of comorbidities on therapeutic progression of diabetes treatment in Australian veterans: a cohort study.

    Directory of Open Access Journals (Sweden)

    Agnes I Vitry

    Full Text Available BACKGROUND: This study assessed whether the number of comorbid conditions unrelated to diabetes was associated with a delay in therapeutic progression of diabetes treatment in Australian veterans. METHODOLOGY/PRINCIPAL FINDINGS: A retrospective cohort study was undertaken using data from the Australian Department of Veterans' Affairs (DVA claims database between July 2000 and June 2008. The study included new users of metformin or sulfonylurea medicines. The outcome was the time to addition or switch to another antidiabetic treatment. The total number of comorbid conditions unrelated to diabetes was identified using the pharmaceutical-based comorbidity index, Rx-Risk-V. Competing risk regression analyses were conducted, with adjustments for a number of covariates that included age, gender, residential status, use of endocrinology service, number of hospitalisation episodes and adherence to diabetes medicines. Overall, 20,134 veterans were included in the study. At one year, 23.5% of patients with diabetes had a second medicine added or had switched to another medicine, with 41.4% progressing by 4 years. The number of unrelated comorbidities was significantly associated with the time to addition of an antidiabetic medicine or switch to insulin (subhazard ratio [SHR] 0.87 [95% CI 0.84-0.91], P<0.001. Depression, cancer, chronic obstructive pulmonary disease, dementia, and Parkinson's disease were individually associated with a decreased likelihood of therapeutic progression. Age, residential status, number of hospitalisations and adherence to anti-diabetic medicines delayed therapeutic progression. CONCLUSIONS/SIGNIFICANCE: Increasing numbers of unrelated conditions decreased the likelihood of therapeutic progression in veterans with diabetes. These results have implications for the development of quality measures, clinical guidelines and the construction of models of care for management of diabetes in elderly people with comorbidities.

  15. Theoretical reversed field pinch studies: Progress report, August 31, 1987 to June 1988

    International Nuclear Information System (INIS)

    1988-01-01

    This paper describes the progress made in Grant DE-FG02-85ER53212 since the end of the last year, August 31, 1987 to the present (June, 1988). Substantial results have emerged in two areas of high importance to the RFP program - nonlinear evolution with nonideal boundaries and self-consistent equilibrium in the presence of field errors. Both of these topics are critical for a basic understanding of RFP physics, for interpretation of current experiments, and for design of future devices and reactors. 3 refs

  16. Preliminary Systems Design Study assessment report

    International Nuclear Information System (INIS)

    Mayberry, J.L.; Feizollahi, F.; Del Signore, J.C.

    1992-01-01

    The System Design Study (SDS), part of the Waste Technology Development Department at the Idaho National Engineering Laboratory (INEL), examined techniques available for the remediation of hazardous and transuranic waste stored at the Radioactive Waste Management Complex's Subsurface Disposal Area at the INEL. Using specific technologies, system concepts for treating the buried waste and the surrounding contaminated soil were evaluated. Evaluation included implementability, effectiveness, and cost. The SDS resulted in the development of technology requirements including demonstration, testing, and evaluation activities needed for implementing each concept. This volume of the Systems Design Study contain four Appendixes that were part of the study. Appendix A is an EG ampersand G Idaho, Inc., report that represents a review and compilation of previous reports describing the wastes and quantities disposed in the Subsurface Disposal Area of the Idaho National Engineering Laboratory. Appendix B contains the process flowsheets considered in this study, but not selected for detailed analysis. Appendix C is a historical tabulation of radioactive waste incinerators. Appendix D lists Department of Energy facilities where cementation stabilization systems have been used

  17. Design rules of mechanical structure of reactors. Damage due to cyclic loading. Progressive distortion. Practical analysis of ratcheting

    International Nuclear Information System (INIS)

    Clement, Gerard; Cousseran, Pierre; Lebey, Jacques; Moulin, Didier; Roche, Roland; Tremblais, Andre.

    1982-08-01

    At first is given a definition of what is ratcheting. A short discussion shows that computation results do not agree with experimental results. This is attributed to the complexity of the real material behavior. These considerations lead to try to build a design rule mainly based on the results of experimental tests. A large experimental program is in progress at CEN-Saclay. Using these results and the results available in open litterature, it was possible to propose a rule based on the concept of effective primary stress Psub(eff). The effective primary stress is a fictitious primary stress giving the same effects that the real loading (it is to say the same effect that the combination of an applied primary stress P and a cyclic straining). Determination of an upper bound value of Psub(eff) is made with the help of an efficiency diagram. More precisely the efficiency diagram include a curve giving a conservative value of an efficiency index V=P/Psub(eff) as a function of the secondary quotient SQ=ΔQ/P. Finally limitation of Psub(eff) intensity is discussed in regard with the current practice [fr

  18. VXIbus data collection system -- A design study

    International Nuclear Information System (INIS)

    Hacker, U.; Richter, B.; Weinert, A.; Arlt, R.; Lewis, W.; Swinhoe, M.

    1995-01-01

    The German support program has sponsored the work to investigate the VXIbus as integration platform for safeguards instrumentation. This paper will cover the analysis of the user requirements for a VXIbus based monitoring system for integrated safeguards -- primarily for reliable unattended in-field collection of large amounts of data. The goal is to develop a suitable system architecture. The design of the system makes use of the VXIbus standard as the selected hardware platform Based upon the requirement analysis and the overriding need for high reliability and robustness, a systematic investigation of different operating system options, as well as development and integration tools will be considered. For the software implementation cycle high and low level programming tools are required. The identification of the constraints for the programming platform and the tool selection will be presented. Both the strategic approach, the rules for analysis and design work as well as the executive components for the support of the implementation and production cycle are given. Here all the conditions for reliable, unattended and integrated safeguards monitoring systems will be addressed. The definition of the basic and advanced design principles are covered. The paper discusses the results of a study on a system produced to demonstrate a high data rate timer/counter application

  19. Fuel pin design algorithm for conceptual design studies

    International Nuclear Information System (INIS)

    Uselman, J.P.

    1979-01-01

    Two models are available which are currently verified by part of the requirements and which are adaptable as algorithms for the complete range. Fuel thermal performance is described by the HEDL SIEX model. Cladding damage and total deformation are determined by the GE GRO-II structural analysis code. A preliminary fuel pin performance model for analysis of (U, P/sub U/)O 2 pins in the COROPT core conceptual design system has been constructed by combining the key elements of SIEX and GRO-II. This memo describes the resulting pin performance model and its interfacing with COROPT system. Some exemplary results are presented

  20. Protecting count queries in study design.

    Science.gov (United States)

    Vinterbo, Staal A; Sarwate, Anand D; Boxwala, Aziz A

    2012-01-01

    Today's clinical research institutions provide tools for researchers to query their data warehouses for counts of patients. To protect patient privacy, counts are perturbed before reporting; this compromises their utility for increased privacy. The goal of this study is to extend current query answer systems to guarantee a quantifiable level of privacy and allow users to tailor perturbations to maximize the usefulness according to their needs. A perturbation mechanism was designed in which users are given options with respect to scale and direction of the perturbation. The mechanism translates the true count, user preferences, and a privacy level within administrator-specified bounds into a probability distribution from which the perturbed count is drawn. Users can significantly impact the scale and direction of the count perturbation and can receive more accurate final cohort estimates. Strong and semantically meaningful differential privacy is guaranteed, providing for a unified privacy accounting system that can support role-based trust levels. This study provides an open source web-enabled tool to investigate visually and numerically the interaction between system parameters, including required privacy level and user preference settings. Quantifying privacy allows system administrators to provide users with a privacy budget and to monitor its expenditure, enabling users to control the inevitable loss of utility. While current measures of privacy are conservative, this system can take advantage of future advances in privacy measurement. The system provides new ways of trading off privacy and utility that are not provided in current study design systems.

  1. Preliminary systems design study assessment report

    International Nuclear Information System (INIS)

    Mayberry, J.L.; Feizollahi, F.; Del Signore, J.C.

    1991-09-01

    The System Design Study (SDS), part of the Waste Technology Development Department at the Idaho National Engineering Laboratory (INEL), examined techniques available for the remediation of hazardous and transuranic waste stored at the Radioactive Waste Management Complex's Subsurface Disposal Area at the INEL. Using specific technologies, system concepts for treating the buried waste and the surrounding contaminated soil were evaluated. Evaluation included implementability, effectiveness, and cost. The SDS resulted in the development of technology requirements including demonstration, testing, and evaluation activities needed for implementing each concept

  2. SP-100 radiator design trade study

    International Nuclear Information System (INIS)

    Ewell, R.

    1992-01-01

    This paper reports on a design trade study of the SP-100 heat rejection subsystem (HRSS) which was made. A system code was used to evaluate the sensitivity of the HRSS mass and performance to changes. Variations in heat pipe diameter and cross-section, fin length and thickness, armor thickness, and overall configuration and materials were evaluated. The analysis indicates that the minimum system mass occurs for the case with many small diameter heat pipes, with ducting that maximizes the fraction of the heat pipe evaporator perimeter in contract with it

  3. Design studies of the LHC beam dump

    CERN Document Server

    Zazula, J M

    1997-01-01

    This paper is a compilation of the results of the recent 5 years studies of the beam dump system for the LHC proton collider at CERN, with a special emphasis on feasibility of the central absorber. Simulations of energy deposition by particle cascades, optimisation of the beam sweeping system and core layout, and thermal analysis have been completed; the structural deformation, stress and vibration analyses are well advanced, and a new concept of the shielding design has recently been approved. The material characteristics, geometry, performance parameters and safety precautions for different components of the beam dump are actually close to completion, which augurs well for the start of construction work according to schedule.

  4. /sup 131/I albumin study of patients carrying progressive systemic sclerosis

    Energy Technology Data Exchange (ETDEWEB)

    Cossermelli, W; Carvalho, N; Papaleo Netto, M [Sao Paulo Univ. (Brazil). Centro de Medicina Nuclear

    1974-05-01

    /sup 131/I albumin metabolic changes were studied in 14 female patients with progressive systemic sclerosis. A statistical study of the gathered data disclosed increased distribution and turnover half-life and diminished turnover rate of radioactive substance. Since T/2 of turnover and turnover rate are the result produced by the albumin synthesis and degradation, they are probably lowered during active disease causing hypoalbuminemia. The aminoacids also are probably absorbed by other protein like the gammaglobuline synthesis.

  5. Towards an understanding of career progression for female professors of nursing: a small scale study

    OpenAIRE

    Joyce, Maria

    2012-01-01

    The aim of this study was to generate knowledge of career progression for women professors of nursing, an under researched topic, in order to understand how their professional and personal experiences may have influenced their aspirations and opportunities for career success. This qualitative study gave voice to a small group of women professors of nursing through individual narrative semi-structured interviews, a relatively under-used methodology. The findings are anticipated to have currenc...

  6. Progress in the development of methodology for fusion safety systems studies

    International Nuclear Information System (INIS)

    Ho, S.K.; Cambi, G.; Ciattaglia, S.; Fujii-e, Y.; Seki, Y.

    1994-01-01

    The development of fusion safety systems-study methodology, including the aspects of schematic classification of overall fusion safety system, qualitative assessment of fusion system for identification of critical accident scenarios, quantitative analysis of accident consequences and risk for safety design evaluation, and system-level analysis of accident consequences and risk for design optimization, by a consortium of international efforts is presented. The potential application of this methodology into reactor design studies will facilitate the systematic assessment of safety performance of reactor designs and enhance the impacts of safety considerations on the selection of design configurations

  7. Filtering data from the collaborative initial glaucoma treatment study for improved identification of glaucoma progression.

    Science.gov (United States)

    Schell, Greggory J; Lavieri, Mariel S; Stein, Joshua D; Musch, David C

    2013-12-21

    Open-angle glaucoma (OAG) is a prevalent, degenerate ocular disease which can lead to blindness without proper clinical management. The tests used to assess disease progression are susceptible to process and measurement noise. The aim of this study was to develop a methodology which accounts for the inherent noise in the data and improve significant disease progression identification. Longitudinal observations from the Collaborative Initial Glaucoma Treatment Study (CIGTS) were used to parameterize and validate a Kalman filter model and logistic regression function. The Kalman filter estimates the true value of biomarkers associated with OAG and forecasts future values of these variables. We develop two logistic regression models via generalized estimating equations (GEE) for calculating the probability of experiencing significant OAG progression: one model based on the raw measurements from CIGTS and another model based on the Kalman filter estimates of the CIGTS data. Receiver operating characteristic (ROC) curves and associated area under the ROC curve (AUC) estimates are calculated using cross-fold validation. The logistic regression model developed using Kalman filter estimates as data input achieves higher sensitivity and specificity than the model developed using raw measurements. The mean AUC for the Kalman filter-based model is 0.961 while the mean AUC for the raw measurements model is 0.889. Hence, using the probability function generated via Kalman filter estimates and GEE for logistic regression, we are able to more accurately classify patients and instances as experiencing significant OAG progression. A Kalman filter approach for estimating the true value of OAG biomarkers resulted in data input which improved the accuracy of a logistic regression classification model compared to a model using raw measurements as input. This methodology accounts for process and measurement noise to enable improved discrimination between progression and nonprogression

  8. Lung microbiome and disease progression in idiopathic pulmonary fibrosis: an analysis of the COMET study.

    Science.gov (United States)

    Han, MeiLan K; Zhou, Yueren; Murray, Susan; Tayob, Nabihah; Noth, Imre; Lama, Vibha N; Moore, Bethany B; White, Eric S; Flaherty, Kevin R; Huffnagle, Gary B; Martinez, Fernando J

    2014-07-01

    The role of the lung microbiome in the pathogenesis of idiopathic pulmonary fibrosis is unknown. We investigated whether unique microbial signatures were associated with progression of idiopathic pulmonary fibrosis. Patients (aged 35-80 years) with idiopathic pulmonary fibrosis within 4 years of diagnosis from the Correlating Outcomes with biochemical Markers to Estimate Time-progression (COMET) in idiopathic pulmonary fibrosis study were followed up for a maximum of 80 weeks. Progression-free survival was defined as time to death, acute exacerbation, lung transplant, or decrease in forced vital capacity (FVC) of 10% or greater or decrease in diffusion capacity of the lung (DLCO) of 15% or greater. DNA was isolated from 55 samples of bronchoscopic alveolar lavage. 454 pyrosequencing was used to assign operational taxonomic units (OTUs) to bacteria based on a 3% sequence divergence. Adjusted Cox models were used to identify OTUs that were significantly associated with progression-free survival at a pidiopathic pulmonary fibrosis is associated with the presence of specific members within the Staphylococcus and Streptococcus genera. Additional research will be needed to identify the specific bacterial species and to ascertain whether this is a causal association. National Institutes of Health. Copyright © 2014 Elsevier Ltd. All rights reserved.

  9. Nuclear medicine and imaging research (quantitative studies in radiopharmaceutical science). Progress report, January 1, 1984-December 31, 1984

    International Nuclear Information System (INIS)

    Beck, R.N.; Cooper, M.D.

    1984-09-01

    This report presents progress in the areas of cardiac nuclear medicine, other imaging studies, investigations with biomolecules, and assessment of risks associated with the clinical use of radiopharmaceuticals

  10. Task I. Basic mirror studies. Task II. Basic tokamak studies. Annual progress report

    International Nuclear Information System (INIS)

    Smullin, L.D.; Bekefi, G.; Porkolab, M.

    1979-01-01

    Brief discussions of research progress are given for each of the following areas: (1) building equipment, (2) rf heating, (3) interferometry, (4) gas puffing, (5) mm collective scattering, (6) uv spectroscopy, (7) soft x radiation, (8) charge exchange, and (9) Thomson scattering

  11. Genetic Breeding and Diversity of the Genus Passiflora: Progress and Perspectives in Molecular and Genetic Studies

    Directory of Open Access Journals (Sweden)

    Carlos Bernard M. Cerqueira-Silva

    2014-08-01

    Full Text Available Despite the ecological and economic importance of passion fruit (Passiflora spp., molecular markers have only recently been utilized in genetic studies of this genus. In addition, both basic genetic researches related to population studies and pre-breeding programs of passion fruit remain scarce for most Passiflora species. Considering the number of Passiflora species and the increasing use of these species as a resource for ornamental, medicinal, and food purposes, the aims of this review are the following: (i to present the current condition of the passion fruit crop; (ii to quantify the applications and effects of using molecular markers in studies of Passiflora; (iii to present the contributions of genetic engineering for passion fruit culture; and (iv to discuss the progress and perspectives of this research. Thus, the present review aims to summarize and discuss the relationship between historical and current progress on the culture, breeding, and molecular genetics of passion fruit.

  12. Nuclear powered satellite studies. Annual progress report, July 1, 1976--June 30, 1977

    International Nuclear Information System (INIS)

    Kaplan, M.H.

    1977-06-01

    Progress achieved during the period July 1, 1976 to June 30, 1977 is reported. Discussions of several pertinent aspects are included, e.g., schedule, personnel, technology developments, and plans. The reporting period is the first year of activities of a project which is designed to provide continuing support to the Nuclear Research and Applications Division of ERDA. Thus, a significant effort has been made to establish appropriate staff positions and liaison ties with government and industry. Technology developments were achieved and communicated to the scientific community via publications and presentations. Project personnel also participated in design reviews and provided support to ERDA on a real-time basis. The report is intended to summarize activities over the past year and provides a basis for continued project support by ERDA

  13. Nuclear powered satellite studies. Annual progress report, July 1, 1978-June 30, 1979

    International Nuclear Information System (INIS)

    Kaplan, M.H.

    1979-06-01

    Progress achieved during the period July 1, 1978 to June 30, 1979, on US DOE contract No. EY-76-S-02-4045.A002 is reported. Discussions of several pertinent aspects are included, e.g., schedule, personnel, technology developments, and plans. The reporting period represents the third year of activities of a project which is designed to provide continuing support in the area of nuclear space power technology. Important results have been obtained and communicated to the scientific community via publications and presentations. Project personnel have participated in point design efforts, a NASA Space Power Committee, and periodically provide support to Department of Energy activities as the need arises. The report is intended to summarize activities over the past year and provide a basis for continued project support by US DOE

  14. Study Of Lampungnese Traditional Home Garden Design

    Science.gov (United States)

    Pratiwi, R. A.; Gunawan

    2017-10-01

    Lampung is one area in Indonesia which has a traditional culture that comes from two groups of descents, they are ulun Lampung Pepadun and ulun Lampung Saibatin. Lampungnese traditional culture has been well-known by Indonesian people for its traditional dances, traditional clothing, or traditional home architecture. However, Lampungnese traditional home garden recently may not yet been described. Information related to Lampungnese traditional home garden is still very limited and it does not yet represented the culture based design concept. This research was directed to identify the elements of the home garden and map it into design concept of the Lampungnese traditional home garden based on information of Lampungnese traditional culture. The study was conducted by using descriptive approach through literature review, interviews and cultural exploration, as well as field observation. The study was able to identify the elements forming the Lampungnese traditional home garden, namely gakhang hadap, walai, outdoor kitchenette, firewood place, outdoor kitchen, livestock barns, as well as plants. Space layout of the home garden comprises front yard (tengahbah/terambah/beruan), side yard (kebik/kakebik), and backyard (kudan/juyu/kebon). Each element of the garden is located in the right place of the space layout.

  15. Design study of the compact ERL

    International Nuclear Information System (INIS)

    Hajima, Ryoichi; Nakamura, Norio; Sakanaka, Shogo; Kobayashi, Yukinori

    2008-02-01

    Energy-recovery linac (ERL) is a promising device for future X-ray light sources, which can produce coherent X-rays and femto-second X-ray pulses. In Japan, we have organized a collaboration team, consisting of the members of KEK, JAEA, ISSP and other laboratories, toward realization of future ERL light sources, and started R and D efforts to establish accelerator technologies relevant to the ERL light source. In order to demonstrate all the accelerator technologies working together, we have decided to build a small facility, the Compact ERL. This report presents a design study of the Compact ERL, which includes R and D issues for each accelerator component, studies on the beam dynamics, performance of the Compact ERL as a light source of THz and X-ray. (author)

  16. Low activation diagnostic equipment design studies

    International Nuclear Information System (INIS)

    Hopkins, G.R.; Cheng, E.T.; Fisher, R.K.

    1985-01-01

    The low activation fusion concept has been applied to the diagnostic equipment in a fusion reactor. The components where fabrication from low activation materials is feasible have been identified. Other systems where higher activation elements are required can have their activation reduced by design approaches which include shielding and operation only in low flux regions of the reactor. Some components will not operate in a high flux so activation is not a major concern. This low activation diagnostic equipment study completes a series of low activation studies where all the components in a fusion power reactor have now been evaluated. It is concluded that a completely low activation fusion reactor is feasible with all components meeting the functional requirements. This provides an environmentally benign energy source with a high confidence level in meeting safety criteria in operation, maintenance and waste disposal

  17. DEMO port plug design and integration studies

    Science.gov (United States)

    Grossetti, G.; Boccaccini, L. V.; Cismondi, F.; Del Nevo, A.; Fischer, U.; Franke, T.; Granucci, G.; Hernández, F.; Mozzillo, R.; Strauß, D.; Tran, M. Q.; Vaccaro, A.; Villari, R.

    2017-11-01

    The EUROfusion Consortium established in 2014 and composed by European Fusion Laboratories, and in particular the Power Plant Physics and Technology department aims to develop a conceptual design for the Fusion DEMOnstration Power Plant, DEMO. With respect to present experimental machines and ITER, the main goals of DEMO are to produce electricity continuously for a period of about 2 h, with a net electrical power output of a few hundreds of MW, and to allow tritium self-sufficient breeding with an adequately high margin in order to guarantee its planned operational schedule, including all planned maintenance intervals. This will eliminate the need to import tritium fuel from external sources during operations. In order to achieve these goals, extensive engineering efforts as well as physics studies are required to develop a design that can ensure a high level of plant reliability and availability. In particular, interfaces between systems must be addressed at a very early phase of the project, in order to proceed consistently. In this paper we present a preliminary design and integration study, based on physics assessments for the EU DEMO1 Baseline 2015 with an aspect ratio of 3.1 and 18 toroidal field coils, for the DEMO port plugs. These aim to host systems like electron cyclotron heating launchers currently developed within the Work Package Heating and Current Drive that need an external radial access to the plasma and through in-vessel systems like the breeder blanket. A similar approach shown here could be in principle followed by other systems, e.g. other heating and current drive systems or diagnostics. The work addresses the interfaces between the port plug and the blanket considering the helium-cooled pebble bed and the water cooled lithium lead which are two of four breeding blanket concepts under investigation in Europe within the Power Plant Physics and Technology Programme: the required openings will be evaluated in terms of their impact onto the

  18. Preliminary design studies on the Broad Application Test Reactor

    International Nuclear Information System (INIS)

    Terry, W.J.; Terry, W.K.; Ryskamp, J.M.; Jahshan, S.N.; Fletcher, C.D.; Moore, R.L.; Leyse, C.F.; Ottewitte, E.H.; Motloch, C.G.; Lacy, J.M.

    1992-08-01

    This report describes progress made at the Idaho National Engineering Laboratory during the first three quarters of Fiscal Year (FY) 1992 on the Laboratory-Directed Research and Development (LDRD) project to perform preliminary design studies on the Broad Application Test Reactor (BATR). This work builds on the FY-92 BATR studies, which identified anticipated mission and safety requirements for BATR and assessed a variety of reactor concepts for their potential capability to meet those requirements. The main accomplishment of the FY-92 BATR program is the development of baseline reactor configurations for the two conventional conceptual test reactors recommended in the FY-91 report. Much of the present report consists of descriptions and neutronics and thermohydraulics analyses of these baseline configurations. In addition, we considered reactor safety issues, compared the consequences of steam explosions for alternative conventional fuel types, explored a Molten Chloride Fast Reactor concept as an alternate BATR design, and examined strategies for the reduction of operating costs. Work planned for the last quarter of FY-92 is discussed, and recommendations for future work are also presented

  19. Proposal to the United States Energy Research and Development Administration for continuation of fusion reactor technology studies. Progress report October 1, 1977--July 1, 1978

    Energy Technology Data Exchange (ETDEWEB)

    Conn, R.W.; Kulcinski, G.L.; Maynard, C.W.

    1978-01-01

    Since the last progress report we have concentrated on three main areas of research: (1) the study of the NUWMAK reactor design, (2) the study of rf heating for tokamak reactors, and (3) the initiation of a tandem mirror reactor study. The initial work on the tandem mirror reactor is included as background in the technical proposal. Summaries of our work on recent assessments of lithium reserves and neutral transport codes are included.

  20. Proposal to the United States Energy Research and Development Administration for continuation of fusion reactor technology studies. Progress report October 1, 1977--July 1, 1978

    International Nuclear Information System (INIS)

    Conn, R.W.; Kulcinski, G.L.; Maynard, C.W.

    1978-01-01

    Since the last progress report we have concentrated on three main areas of research: (1) the study of the NUWMAK reactor design, (2) the study of rf heating for tokamak reactors, and (3) the initiation of a tandem mirror reactor study. The initial work on the tandem mirror reactor is included as background in the technical proposal. Summaries of our work on recent assessments of lithium reserves and neutral transport codes are included

  1. A systematic review of protocol studies on conceptual design cognition: design as search and exploration

    OpenAIRE

    Hay, Laura; Duffy, Alex H.B.; McTeague, Chris; Pidgeon, Laura M.; Vuletic, Tijana; Grealy, Madeleine

    2017-01-01

    This paper reports findings from the first systematic review of protocol studies focusing specifically on conceptual design cognition, aiming to answer the following research question: What is our current understanding of the cognitive processes involved in conceptual design tasks carried out by individual designers? We reviewed 47 studies on architectural design, engineering design and product design engineering. This paper reports 24 cognitive processes investigated in a subset of 33 studie...

  2. Monitoring Progression of Amyotrophic Lateral Sclerosis Using Ultrasound Morpho-Textural Muscle Biomarkers: A Pilot Study.

    Science.gov (United States)

    Martínez-Payá, Jacinto J; Ríos-Díaz, José; Medina-Mirapeix, Francesc; Vázquez-Costa, Juan F; Del Baño-Aledo, María Elena

    2018-01-01

    The need is increasing for progression biomarkers that allow the loss of motor neurons in amyotrophic lateral sclerosis (ALS) to be monitored in clinical trials. In this prospective longitudinal study, muscle thickness, echointensity, echovariation and gray level co-occurrence matrix textural features are examined as possible progression ultrasound biomarkers in ALS patients during a 5-mo follow-up period. We subjected 13 patients to 3 measurements for 20 wk. They showed a significant loss of muscle, an evident tendency to loss of thickness and increased echointensity and echovariation. In regard to textural parameters, muscle heterogeneity tended to increase as a result of the neoformation of non-contractile tissue through denervation. Considering some limitations of the study, the quantitative muscle ultrasound biomarkers evaluated showed a promising ability to monitor patients affected by ALS. Copyright © 2018 World Federation for Ultrasound in Medicine and Biology. Published by Elsevier Inc. All rights reserved.

  3. Review of levoglucosan in glacier snow and ice studies: Recent progress and future perspectives.

    Science.gov (United States)

    You, Chao; Xu, Chao

    2018-03-01

    Levoglucosan (LEV) in glacier snow and ice layers provides a fingerprint of fire activity, ranging from modern air pollution to ancient fire emissions. In this study, we review recent progress in our understanding and application of LEV in glaciers, including analytical methods, transport and post-depositional processes, and historical records. We firstly summarize progress in analytical methods for determination of LEV in glacier snow and ice. Then, we discuss the processes influencing the records of LEV in snow and ice layers. Finally, we make some recommendations for future work, such as assessing the stability of LEV and obtaining continuous records, to increase reliability of the reconstructed ancient fire activity. This review provides an update for researchers working with LEV and will facilitate the further use of LEV as a biomarker in paleo-fire studies based on ice core records. Copyright © 2017 Elsevier B.V. All rights reserved.

  4. The Effectiveness of the Progression of Widex Zen Tinnitus Therapy: A Pilot Study.

    Science.gov (United States)

    Tyler, Richard S; Deshpande, Aniruddha K; Lau, Chi C; Kuk, Francis

    2017-09-18

    The aim of this study was to measure the progression of benefits to individuals with tinnitus from providing informational counseling, hearing aids, a brief tinnitus activities treatment and Zen therapy. Several magnitude estimation scales and tinnitus handicap scales were administered for the duration of the study to 20 participants. Results indicated that all participants benefited from this sequential approach of providing different components of this tinnitus treatment. Large benefits were observed following the tinnitus activities treatment and the Zen treatments. We conclude that the progressive approach of treatment demonstrated here should be of benefit to most individuals with tinnitus and that the Widex Zen sound therapy is a worthwhile treatment for many tinnitus sufferers.

  5. Inertial Motion Capture Costume Design Study

    Directory of Open Access Journals (Sweden)

    Agnieszka Szczęsna

    2017-03-01

    Full Text Available The paper describes a scalable, wearable multi-sensor system for motion capture based on inertial measurement units (IMUs. Such a unit is composed of accelerometer, gyroscope and magnetometer. The final quality of an obtained motion arises from all the individual parts of the described system. The proposed system is a sequence of the following stages: sensor data acquisition, sensor orientation estimation, system calibration, pose estimation and data visualisation. The construction of the system’s architecture with the dataflow programming paradigm makes it easy to add, remove and replace the data processing steps. The modular architecture of the system allows an effortless introduction of a new sensor orientation estimation algorithms. The original contribution of the paper is the design study of the individual components used in the motion capture system. The two key steps of the system design are explored in this paper: the evaluation of sensors and algorithms for the orientation estimation. The three chosen algorithms have been implemented and investigated as part of the experiment. Due to the fact that the selection of the sensor has a significant impact on the final result, the sensor evaluation process is also explained and tested. The experimental results confirmed that the choice of sensor and orientation estimation algorithm affect the quality of the final results.

  6. Second Generation Waste Package Design Study

    International Nuclear Information System (INIS)

    Armijo, J.S.; Misra, M.; Kar, Piyush

    2007-01-01

    The following describes the objectives of Project Activity 023 ''Second Generation Waste Package Design Study'' under DOE Cooperative Agreement DE-FC28-04RW12232. The objectives of this activity are: to review the current YMP baseline environment and establish corrosion test environments representative of the range of dry to intermittently wet conditions expected in the drifts as a function of time; to demonstrate the oxidation and corrosion resistance of A588 weathering steel and reference Alloy 22 samples in the representative dry to intermittently dry conditions; and to evaluate backfill and design features to improve the thermal performance analyses of the proposed second-generation waste packages using existing models developed at the University of Nevada, Reno(UNR). The work plan for this project activity consists of three major tasks: Task 1. Definition of expected worst-case environments (humidity, liquid composition and temperature) at waste package outer surfaces as a function of time, and comparison with environments defined in the YMP baseline; Task 2. Oxidation and corrosion tests of proposed second-generation outer container material; and Task 3. Second Generation waste package thermal analyses. Full funding was not provided for this project activity

  7. Large Coil Program magnetic system design study

    International Nuclear Information System (INIS)

    Moses, S.D.; Johnson, N.E.

    1977-01-01

    The primary objective of the Large Coil Program (LCP) is to demonstrate the reliable operation of large superconducting coils to provide a basis for the design principles, materials, and fabrication techniques proposed for the toroidal magnets for the THE NEXT STEP (TNS) and other future tokamak devices. This paper documents a design study of the Large Coil Test Facility (LCTF) in which the structural response of the Toroidal Field (TF) Coils and the supporting structure was evaluated under simulated reactor conditions. The LCP test facility structural system consists of six TF Coils, twelve coil-to-coil torsional restraining beams (torque rings), a central bucking post with base, and a Pulse Coil system. The NASTRAN Finite Element Structural Analysis computer Code was utilized to determine the distribution of deflections, forces, and stresses for each of the TF Coils, torque rings, and the central bucking post. Eleven load conditions were selected to represent probable test operations. Pulse Coils suspended in the bore of the test coil were energized to simulate the pulsed field environment characteristic of the TNS reactor system. The TORMAC Computer Code was utilized to develop the magnetic forces in the TF Coils for each of the eleven loading conditions examined, with or without the Pulse Coils energized. The TORMAC computer program output forces were used directly as input load conditions for the NASTRAN analyses. Results are presented which demonstrate the reliability of the LCTF under simulated reactor operating conditions

  8. Next Step Spherical Torus Design Studies

    International Nuclear Information System (INIS)

    Neumeyer, C.; Heitzenroeder, P.; Kessel, C.; Ono, M.; Peng, M.; Schmidt, J.; Woolley, R.; Zatz, I.

    2002-01-01

    Studies are underway to identify and characterize a design point for a Next Step Spherical Torus (NSST) experiment. This would be a ''Proof of Performance'' device which would follow and build upon the successes of the National Spherical Torus Experiment (NSTX) a ''Proof of Principle'' device which has operated at PPPL since 1999. With the Decontamination and Decommissioning (DandD) of the Tokamak Fusion Test Reactor (TFTR) nearly completed, the TFTR test cell and facility will soon be available for a device such as NSST. By utilizing the TFTR test cell, NSST can be constructed for a relatively low cost on a short time scale. In addition, while furthering spherical torus (ST) research, this device could achieve modest fusion power gain for short-pulse lengths, a significant step toward future large burning plasma devices now under discussion in the fusion community. The selected design point is Q=2 at HH=1.4, P subscript ''fusion''=60 MW, 5 second pulse, with R subscript ''0''=1.5 m, A=1.6, I subscript ''p''=10vMA, B subscript ''t''=2.6 T, CS flux=16 weber. Most of the research would be conducted in D-D, with a limited D-T campaign during the last years of the program

  9. Radiation biophysical study of biological molecules. Progress report, July 1, 1976--August 31, 1977

    International Nuclear Information System (INIS)

    Fluke, D.J.

    1977-01-01

    Progress is reported on the following research projects: x-ray induction of uv mutagenesis enhancement in lambda-phage; action spectrum for uv mutagenesis in Escherichia coli; survival of E. coli colonies after uv damage; repair of radiation damage to lambda-phage by the W-reactivation system; experiments on the Weigle-reactivation of irradiated lambda-phage; and studies on the wavelength dependence of uv mutagenesis

  10. Studies of heavy fermion systems: Progress report, July 1, 1986-December 31, 1988

    International Nuclear Information System (INIS)

    Stewart, G.R.

    1988-01-01

    Major projects put forward in the original proposal were: radiation damage studies of the heavy fermion superconductors UBe 13 and UPt 3 ; chemical substitution experiments, including CeCu/sub 6-x/M/sub x/; high magnetic field specific heat measurements; search for new heavy fermion systems (HFS). A summary of results on these projects will be discussed first, followed by additional work done during the contract period - some of which is still in progress

  11. Progressive exhaustion: A qualitative study on the experiences of Iranian family caregivers regarding patients undergoing hemodialysis

    Directory of Open Access Journals (Sweden)

    Shahriar Salehitali

    2018-04-01

    Full Text Available Objective: The aim of this study was to explore the burden of care for patients undergoing hemodialysis from the experiences of family caregivers. Methods: In this qualitative study, a content analysis approach was used for data collection and analysis. Participants were 16 family caregivers selected through purposive sampling from four medical education centers affiliated with Ahvaz Jundishapur University of Medical Sciences, Iran. Semi-structured interviews were held to collect data. Results: Four categories were developed as follows: ‘care challenges’, ‘psychological vulnerabilities’, ‘the chronic nature of care ’and “care in the shade”. The categories led to the development of the main theme of ‘progressive exhaustion’ experienced by the family caregivers during the provision of care to patients undergoing hemodialysis. Conclusion: Family caregivers have a significant role in the process of patient care, and this role leads them to progressive exhaustion; therefore, the overall health of the caregivers should be taken into account and more attention should be paid to their quality of life, social welfare, and satisfaction level. Keywords: Family caregivers, Hemodialysis, Progressive exhaustion, Qualitative study

  12. Behavior of wet precast beam column connections under progressive collapse scenario: an experimental study

    Science.gov (United States)

    Nimse, Rohit B.; Joshi, Digesh D.; Patel, Paresh V.

    2014-12-01

    Progressive collapse denotes a failure of a major portion of a structure that has been initiated by failure of a relatively small part of the structure such as failure of any vertical load carrying element (typically columns). Failure of large part of any structure will results into substantial loss of human lives and natural resources. Therefore, it is important to prevent progressive collapse which is also known as disproportionate collapse. Nowadays, there is an increasing trend toward construction of buildings using precast concrete. In precast concrete construction, all the components of structures are produced in controlled environment and they are being transported to the site. At site such individual components are connected appropriately. Connections are the most critical elements of any precast structure, because in past major collapse of precast structure took place because of connection failure. In this study, behavior of three different 1/3rd scaled wet precast beam column connections under progressive collapse scenario are studied and its performance is compared with monolithic connection. Precast connections are constructed by adopting different connection detailing at the junction by considering reinforced concrete corbel for two specimens and steel billet for one specimen. Performance of specimen is evaluated on the basis of ultimate load carrying capacity, maximum deflection and deflection measured along the span of the beam. From the results, it is observed that load carrying capacity and ductility of precast connections considered in this study are more than that of monolithic connections.

  13. Classifying the Progression of Ductal Carcinoma from Single-Cell Sampled Data via Integer Linear Programming: A Case Study.

    Science.gov (United States)

    Catanzaro, Daniele; Shackney, Stanley E; Schaffer, Alejandro A; Schwartz, Russell

    2016-01-01

    Ductal Carcinoma In Situ (DCIS) is a precursor lesion of Invasive Ductal Carcinoma (IDC) of the breast. Investigating its temporal progression could provide fundamental new insights for the development of better diagnostic tools to predict which cases of DCIS will progress to IDC. We investigate the problem of reconstructing a plausible progression from single-cell sampled data of an individual with synchronous DCIS and IDC. Specifically, by using a number of assumptions derived from the observation of cellular atypia occurring in IDC, we design a possible predictive model using integer linear programming (ILP). Computational experiments carried out on a preexisting data set of 13 patients with simultaneous DCIS and IDC show that the corresponding predicted progression models are classifiable into categories having specific evolutionary characteristics. The approach provides new insights into mechanisms of clonal progression in breast cancers and helps illustrate the power of the ILP approach for similar problems in reconstructing tumor evolution scenarios under complex sets of constraints.

  14. Study and Design of Differential Microphone Arrays

    CERN Document Server

    Benesty, Jacob

    2013-01-01

    Microphone arrays have attracted a lot of interest over the last few decades since they have the potential to solve many important problems such as noise reduction/speech enhancement, source separation, dereverberation, spatial sound recording, and source localization/tracking, to name a few. However, the design and implementation of microphone arrays with beamforming algorithms is not a trivial task when it comes to processing broadband signals such as speech. Indeed, in most sensor arrangements, the beamformer tends to have a frequency-dependent response. One exception, perhaps, is the family of differential microphone arrays (DMAs) that have the promise to form frequency-independent responses. Moreover, they have the potential to attain high directional gains with small and compact apertures. As a result, this type of microphone arrays has drawn much research and development attention recently. This book is intended to provide a systematic study of DMAs from a signal processing perspective. The primary obj...

  15. Preliminary systems design study assessment report

    International Nuclear Information System (INIS)

    Mayberry, J.L.; Feizollahi, F.; Del Signore, J.C.

    1992-01-01

    The System Design Study (SDS), part of the Waste Technology Development Department at the Idaho National Engineering Laboratory (INEL), examined techniques available for the remediation of hazardous and transuranic waste stored at the Radioactive Waste Management Complex's Subsurface Disposal Area at the INEL. Using specific technologies, system concepts for treating the buried waste and the surrounding contaminated soil were evaluated. Evaluation included implementability, effectiveness, and cost. The SDS resulted in the development of technology requirements including demonstration, testing, and evaluation activities needed for implementing each. This volume contains the descriptions and other relevant information of the four subsystems required for most of the ex situ processing systems. This volume covers the metal decontamination and sizing subsystem, soils processing subsystem, low-level waste subsystem, and retrieval subsystem

  16. Design study of prestressed rotor spar concept

    Science.gov (United States)

    Gleich, D.

    1980-01-01

    Studies on the Bell Helicopter 540 Rotor System of the AH-1G helicopter were performed. The stiffness, mass and geometric configurations of the Bell blade were matched to give a dynamically similar prestressed composite blade. A multi-tube, prestressed composite spar blade configuration was designed for superior ballistic survivability at low life cycle cost. The composite spar prestresses, imparted during fabrication, are chosen to maintain compression in the high strength cryogenically stretchformed 304-L stainless steel liner and tension in the overwrapped HTS graphite fibers under operating loads. This prestressing results in greatly improved crack propagation and fatigue resistance as well as enhanced fiber stiffness properties. Advantages projected for the prestressed composite rotor spar concept include increased operational life and improved ballistic survivability at low life cycle cost.

  17. Preliminary Systems Design Study assessment report

    International Nuclear Information System (INIS)

    Mayberry, J.L.; Quapp, W.J.; Feizollahi, F.; Del Signore, J.C.

    1991-07-01

    The System Design Study (SDS), part of the Waste Technology Development Department at Idaho National Engineering Laboratory (INEL), examined techniques available for the remediation of hazardous and transuranic (TRU) waste stored at the Radioactive Waste Management Complex's (RWMC's) Subsurface Disposal Area (SDA) at INEL. Using specific technologies, system concepts for treating the buried waste and the surrounding contaminated soil were evaluated. Evaluation included implementability, effectiveness, and cost. SDS resulted in the development of technology requirements including demonstration, testing and evaluation activities needed for implementing each concept. The SDS results are published in eight volumes. Volume 1 contains an executive summary. The SDS summary and analysis of results are presented in volume 2. Volumes 3 through 7 contain detailed descriptions of twelve system and four subsystem concepts. Volume 8 contains the appendices. 3 figs., 3 tabs

  18. Preliminary Systems Design Study assessment report

    International Nuclear Information System (INIS)

    Mayberry, J.L.; Quapp, W.J.; Feizollahi, F.; Del Signore, J.C.

    1991-07-01

    The System Design Study (SDS), part of the Waste Technology Development Department at the Idaho National Engineering Laboratory (INEL), examined techniques available for the remediation of hazardous and transuranic waste stored at the Radioactive Waste Management Complex's Subsurface Disposal Area at the INEL. Using specific technologies, system concepts for treating the buried waste and the surrounding contaminated soil were evaluated. Evaluation included implementability, effectiveness, and cost. SDS resulted in the development of technology requirements including demonstration, testing, and evaluation activities needed for implementing each concept. The SDS results are published in eight volumes. Volume 1 contains an executive summary. The SDS summary and analysis of results are presented in Volume 2. Volumes 3 through 7 contain detailed descriptions of twelve system and four subsystem concepts. Volume 8 contains the appendixes. 23 refs., 23 figs., 16 tabs

  19. Progressive resistance training in head and neck cancer patients during concomitant chemoradiotherapy -- design of the DAHANCA 31 randomized trial.

    Science.gov (United States)

    Lonkvist, Camilla K; Lønbro, Simon; Vinther, Anders; Zerahn, Bo; Rosenbom, Eva; Primdahl, Hanne; Hojman, Pernille; Gehl, Julie

    2017-06-03

    Head and neck cancer patients undergoing concomitant chemoradiotherapy (CCRT) frequently experience loss of muscle mass and reduced functional performance. Positive effects of exercise training are reported for many cancer types but biological mechanisms need further elucidation. This randomized study investigates whether progressive resistance training (PRT) may attenuate loss of muscle mass and functional performance. Furthermore, biochemical markers and muscle biopsies will be investigated trying to link biological mechanisms to training effects. At the Departments of Oncology at Herlev and Aarhus University Hospitals, patients with stage III/IV squamous cell carcinoma of the head and neck, scheduled for CCRT are randomized 1:1 to either a 12-week PRT program or control group, both with 1 year follow-up. Planned enrollment is 72 patients, and stratification variables are study site, sex, p16-status, and body mass index. Primary endpoint is difference in change in lean body mass (LBM) after 12 weeks of PRT, assessed by dual-energy X-ray absorptiometry (DXA). The hypothesis is that 12 weeks of PRT can attenuate the loss of LBM by at least 25%. Secondary endpoints include training adherence, changes in body composition, muscle strength, functional performance, weight, adverse events, dietary intake, self-reported physical activity, quality of life, labor market affiliation, blood biochemistry, plasma cytokine concentrations, NK-cell frequency in blood, sarcomeric protein content in muscles, as well as muscle fiber type and fiber size in muscle biopsies. Muscle biopsies are optional. This randomized study investigates the impact of a 12-week progressive resistance training program on lean body mass and several other physiological endpoints, as well as impact on adverse events and quality of life. Furthermore, a translational approach is integrated with extensive biological sampling and exploration into cytokines and mechanisms involved. The current paper discusses

  20. A qualitative study of implementation and adaptations to Progressive Tinnitus Management (PTM) delivery.

    Science.gov (United States)

    Tuepker, Anaïs; Elnitsky, Christine; Newell, Summer; Zaugg, Tara; Henry, James A

    2018-01-01

    Tinnitus is a common condition, especially prevalent among military Veterans. Progressive Tinnitus Management (PTM) is an interdisciplinary, structured, stepped-care approach to providing clinical services, including teaching coping skills, to people bothered by tinnitus. PTM has been shown to be effective at reducing functional distress, but implementation of the intervention outside of a research setting has not been studied, even though dissemination is underway within the Veterans Health Administration (VHA) system in the United States. This study was designed to address a gap in knowledge of PTM clinical implementation to date, with a focus on factors facilitating or hindering implementation in VHA audiology and mental health clinic contexts, and whether implementing sites had developed intervention adaptations. Qualitative interviews were conducted with 21 audiology and mental health clinicians and service chiefs across a regional service network. Interviews were transcribed and coded using a hybrid inductive-deductive analytic approach guided by existing implementation research frameworks and then iteratively developed for emergent themes. PTM prioritization was rare overall, with providers across disciplines challenged by lack of capacity for implementation, but with differences by discipline in challenges to prioritization. Where PTM was prioritized and delivered, this was facilitated by perception of unique value, provider's own experience of tinnitus, observation/experience with PTM delivery, intervention fit with provider's skills, and an environment with supportive leadership and adaptive reserve. PTM was frequently adapted to local contexts to address delivery challenges and diversify patient options. Adaptations included shifting from group to individual formats, reducing or combining sessions, and employing novel therapeutic approaches. Existing adaptations highlight the need to better understand mechanisms underlying PTM's effectiveness, and

  1. Factors Influencing the Degree Progress of International PhD Students from Africa: An Exploratory Study

    Directory of Open Access Journals (Sweden)

    Almoustapha Oumarou Soumana

    2017-05-01

    Full Text Available In recent decades some countries of the Middle East have offered facilities to attract international students to pursue their higher education within their higher education institutions. The purpose of this study is to understand the difficulties faced by these students while conducting their studies abroad, and in doing so, to broaden the awareness of the challenges they face to complete their research. The participants of this qualitative study are international PhD students studying at a Middle Eastern public university. The university has reported increasing enrollment of international students, particularly from Africa in the last few years. Data were collected using a set of semi-structured interviews that drew out information on critical incidents that characterized the kind of difficulties students had faced in their studies. The data collected was further analyzed using a qualitative software package, NVivo (QSR International, 11. Six main themes came out from the content analysis of the interviews, which are the role of the adviser, student features, funding issues, family engagement, research and psychological obstacles which provide a holistic picture of student perspectives on the factors that influence degree progress. While these students might have faced difficulties mentioned in existing literature, this study argues that the participants have indicated experiencing psychological obstacles that were not described in earlier studies, such as the state of mind they were in as a result of being worried for family members due to war or violence in their home countries, and drop in currency exchange rates and difficulties in acquiring money due to international sanctions imposed against their countries. This study provides important thoughts on the factors that impact the degree progress of international PhD students from Africa, while at the same time revealing a serious gap in the advisers’ role which can contribute to the

  2. Numerical study of how creep and progressive stiffening affect the growth stress formation in trees

    DEFF Research Database (Denmark)

    Ormarsson, Sigurdur; Dahlblom, O.; Johansson, M.

    2010-01-01

    It is not fully understood how much growth stresses affect the final quality of solid timber products in terms of e.g. shape stability. It is for example difficult to predict the internal growth stress field within the tree stem. Growth stresses are progressively generated during the tree growth...... and they are highly influenced by climate, biologic and material related factors. To increase the knowledge of the stress formation a finite element model was created to study how the growth stresses develop during the tree growth. The model is an axisymmetric general plane strain model where material for all new...... annual rings is progressively added to the tree during the analysis. The material model used is based on the theory of small strains (where strains refer to the undeformed configuration which is good approximation for strains less than 4%) where so-called biological maturation strains (growth...

  3. Nuclear spectroscopic studies. Progress report, June 1, 1983-May 31, 1984

    International Nuclear Information System (INIS)

    Bingham, C.R.; Guidry, M.W.; Riedinger, L.L.

    1984-01-01

    Progress is reported on nuclear structure and nuclear reaction studies utilizing heavy-ion beams. Projects at the HHIRF, the Brookhaven Tandem Accelerator, and the Nuclear Science Facility at Daresbury, England are described. Studies have been concentrated on: (1) the structure of deformed and transitional nuclei in the angular momentum range from 20 to 40 h by (HI,xn) reactions; (2) the 1- and 2-nucleon transfer reactions between spherical heavy ion projectiles and deformed targets; and (3) the low-energy properties of nuclei far from stability. Theoretical studies are also reported. Publications are listed

  4. Progression of regional neuropathology in Alzheimer disease and normal elderly: findings from the Nun study.

    Science.gov (United States)

    Wolf, D S; Gearing, M; Snowdon, D A; Mori, H; Markesbery, W R; Mirra, S S

    1999-01-01

    Although diffuse plaques in the neocortex may represent an early stage in the evolution of neuritic plaques, plaques in the striatum and cerebellum retain their predominantly diffuse nature in Alzheimer disease (AD), regardless of disease duration. We had the opportunity to explore the progression of these regional features by using autopsy brain specimens from 15 cognitively normal and five AD subjects, all Catholic sisters enrolled in the Nun Study, a longitudinal study on aging and AD. Neuropathologic changes were assessed in the temporal cortex, striatum, and cerebellum without knowledge of clinical status. We found diffuse plaques in the striatum in six (40%) and cerebellar plaques in none of the brains from the non-demented subjects. Striatal plaques were present in all five and cerebellar plaques in four of the five AD cases. In the 20 cases overall, the presence of striatal plaques generally paralleled the occurrence of neuritic plaques in neocortex and correlated with lower scores on several neuropsychologic tests assessing memory. Our findings suggest that striatal diffuse plaques occur relatively early in the progression of AD pathology and coincide with neocortical pathology and cognitive changes. Thus, it is unlikely that temporal factors alone account for regional differences in progression of AD neuropathology.

  5. Process development studies on the bioconversion of cellulose and production of ethanol. Progress report, September 1, 1978

    Energy Technology Data Exchange (ETDEWEB)

    Wilke, C.R.

    1978-09-01

    Progress is reported in studies on the pretreatment of cellulosic materials to facilitate enzymatic hydrolysis, sulfuric acid hydrolysis, investigation of the Purdue processing scheme including an economic analysis, and the fermentability of the enzymatic hydrolyzate. Progress is also reported on enzyme fermentation studies, hydrolysis reactor development, and utilization of hemicellulose sugars. (JSR)

  6. A generic approach does not work : Disciplinary differences as explanation for study progress in higher professional education

    NARCIS (Netherlands)

    Kamphorst, J. C.; Hofman, W. H. A.; Jansen, E. P. W. A.; Terlouw, C.

    2012-01-01

    A generic approach does not work. Disciplinary differences as explanation for study progress in higher professional education. We combine concepts of Tinto's theory on student departure and Becher's theory on disciplinary tribes for explaining study progress in universities. We collected data with

  7. Design Study for A Low-Cost LH2 Turbopump

    Science.gov (United States)

    Japikse, David; Baines, Nicholas; Platt, Michael J.

    2000-01-01

    A preliminary design study, focusing on potential component selections and design for manufacturing and assembly (DFMAR1) analysis, is presented in this study. The investigation focused on a nominal cost liquid hydrogen turbopump suitable for a private launch class vehicle. Utilizing a "turbocharger-like" design philosophy, preliminary feasibility studies of the basic pump design class, the rotordynamic design class, and the turbine design class were conducted with associated DFMA evaluations. Reasonable cost levels and sensible levels of product assurance have been established.

  8. Safety in the ARIES Tokamak Design Study

    International Nuclear Information System (INIS)

    Herring, J.S.; Wong, C.P.-C.; Cheng, E.T.; Grotz, S.

    1989-01-01

    Safety is one of the primary goals of the ARIES Tokamak Design Study. Public safety goals are the achievement passive safety which is demonstrable in tests that could precede operation and the assurance that releases from accidents be passively limited such that no evacuation plan in necessary. Strategies for safety of the plant investment are factory fabrication, short construction times and a design such that no off-normal operational transient results in damage which could not be repaired in routine maintenance. ARIES-I, the first of three 'visions' of potential tokamak reactors, will use He at 5 MPa as a blanket coolant and SiC/composite ceramic for the first wall and blanket materials. Both the coolant and the structural material were chosen for their low activation, both in the short term after accidents and for long term waste management. The breeder, Li 4 SiO 4 , was also chosen for low activation. Contemporary plasma physics and aggressive technology are used in ARIES-I, which results in very high toroidal fields (24 T maximum at the coil). The stored TF energy will be about 130 GJ. A central concern is the safe discharge of this stored energy under electrical fault conditions and prevention of a failure in the magnet set from propagating into systems containing radioactive inventories. The TF coil system consists of 16 coils, each containing two separate windings powered by two independent power supplies. Arcs and shorts between the two power supply systems and across individual windings have been modeled. In addition, delay or failure in circuit breaker opening has been modeled. The safety impacts of LOCA, LOFA and disruptive events have also been evaluated. 8 refs., 4 figs., 7 tabs

  9. Standard mirror fusion reactor design study

    International Nuclear Information System (INIS)

    Moir, R.W.

    1978-01-01

    This report covers the work of the Magnetic Fusion Energy Division's reactor study group during FY 1976 on the standard mirror reactor. The ''standard'' mirror reactor is characterized as a steady state, neutral beam sustained, D-T fusioning plasma confined by a Yin-Yang magnetic mirror field. The physics parameters are obtained from the same physics model that explains the 2XIIB experiment. The model assumes that the drift cyclotron loss cone mode occurs on the boundary of the plasma, and that it is stabilized by warm plasma with negligible energy investment. The result of the study was a workable mirror fusion power plant, steady-state blanket removal made relatively simple by open-ended geometry, and no impurity problem due to the positive plasma potential. The Q (fusion power/injected beam power) turns out to be only 1.1 because of loss out the ends from Coulomb collisions, i.e., classical losses. This low Q resulted in 77% of the gross electrical power being used to power the injectors, thereby causing the net power cost to be high. The low Q stimulated an intensive search for Q-enhancement concepts, resulting in the LLL reactor design effort turning to the field reversal mirror and the tandem mirror, each having Q of order 5

  10. A case study in value design

    Directory of Open Access Journals (Sweden)

    M. Sinclair

    2003-12-01

    Full Text Available The design of a special type of valve gave rise to a problem which lead the mechanical engineers who designed the valve to call in the help of the author. The final solution to the problem may not be mathematically sophisticated (in fact, it may seem trivial to some readers, but the steps through which the design team struggled and the final approach which resulted in a practically feasible solution may be of interest to other practitioners.

  11. Gene expression study and pathway analysis of histological subtypes of intestinal metaplasia that progress to gastric cancer.

    Directory of Open Access Journals (Sweden)

    Osmel Companioni

    Full Text Available Intestinal metaplasia (IM is a precursor lesion that precedes gastric cancer (GC. There are two IM histological subtypes, complete (CIM and incomplete (IIM, the latter having higher progression rates to GC. This study was aimed at analysing gene expression and molecular processes involved in the progression from normal mucosa to IM, and also from IM subtypes to GC.We used expression data to compare the transcriptome of healthy gastric mucosa to that of IM not progressing to GC, and the transcriptome of IM subtypes that had progressed to GC to those that did not progress. Some deregulated genes were validated and pathway analyses were performed.Comparison of IM subtypes that had progressed to GC with those that did not progress showed smaller differences in the expression profiles than the comparison of IM that did not progress with healthy mucosa. New transcripts identified in IM not progressing to GC included TRIM, TMEM, homeobox and transporter genes and SNORD116. Comparison to normal mucosa identified non tumoral Warburg effect and melatonin degradation as previously unreported processes involved in IM. Overexpressed antigen processing is common to both IM-subtypes progressing to GC, but IIM showed more over-expressed oncogenic genes and molecular processes than CIM.There are greater differences in gene expression and molecular processes involved in the progression from normal healthy mucosa to IM than from IM to gastric cancer. While antigen processing is common in both IM-subtypes progressing to GC, more oncogenic processes are observed in the progression of IIM.

  12. Atrophy progression in semantic dementia with asymmetric temporal involvement: a tensor-based morphometry study.

    Science.gov (United States)

    Brambati, S M; Rankin, K P; Narvid, J; Seeley, W W; Dean, D; Rosen, H J; Miller, B L; Ashburner, J; Gorno-Tempini, M L

    2009-01-01

    We performed a longitudinal anatomical study to map the progression of gray matter atrophy in anatomically defined predominantly left (LTLV) and right (RTLV) temporal lobe variants of semantic dementia (SD). T1-weighted MRI scans were obtained at presentation and one-year follow-up from 13 LTLV, 6 RTLV, and 25 control subjects. Tensor-based morphometry (TBM) in SPM2 was applied to derive a voxel-wise estimation of regional tissue loss over time from the deformation field required to warp the follow-up scan to the presentation scan in each subject. When compared to controls, both LTLV and RTLV showed significant progression of gray matter atrophy not only within the temporal lobe most affected at presentation, but also in the controlateral temporal regions (p<0.05 FWE corrected). In LTLV, significant progression of volume loss also involved the ventromedial frontal and the left anterior insular regions. These results identified the anatomic substrates of the previously reported clinical evolution of LTLV and RTLV into a unique 'merged' clinical syndrome characterized by semantic and behavioral deficits and bilateral temporal atrophy.

  13. Longitudinal study of spatially heterogeneous emphysema progression in current smokers with chronic obstructive pulmonary disease.

    Directory of Open Access Journals (Sweden)

    Naoya Tanabe

    Full Text Available BACKGROUND: Cigarette smoke is the main risk factor for emphysema, which is a key pathology in chronic obstructive pulmonary disease (COPD. Low attenuation areas (LAA in computed tomography (CT images reflect emphysema, and the cumulative size distribution of LAA clusters follows a power law characterized by the exponent D. This property of LAA clusters can be explained by model simulation, where mechanical force breaks alveolar walls causing local heterogeneous lung tissue destruction. However, a longitudinal CT study has not investigated whether continuous smoking causes the spatially heterogeneous progression of emphysema. METHODS: We measured annual changes in ratios of LAA (LAA%, D and numbers of LAA clusters (LAN in CT images acquired at intervals of ≥ 3 years from 22 current and 31 former smokers with COPD to assess emphysema progression. We constructed model simulations using CT images to morphologically interpret changes in current smokers. RESULTS: D was decreased in current and former smokers, whereas LAA% and LAN were increased only in current smokers. The annual changes in LAA%, D, and LAN were greater in current, than in former smokers (1.03 vs. 0.37%, p=0.008; -0.045 vs. -0.01, p=0.004; 13.9 vs. 1.1, p=0.007, respectively. When LAA% increased in model simulations, the coalescence of neighboring LAA clusters decreased D, but the combination of changes in D and LAN in current smokers could not be explained by the homogeneous emphysema progression model despite cluster coalescence. Conversely, a model in which LAAs heterogeneously increased and LAA clusters merged somewhat in relatively advanced emphysematous regions could reflect actual changes. CONCLUSIONS: Susceptibility to parenchymal destruction induced by continuous smoking is not uniform over the lung, but might be higher in local regions of relatively advanced emphysema. These could result in the spatially heterogeneous progression of emphysema in current smokers.

  14. Recent progress in the studies of atomic spectra and transition probabilities by beam-foil spectroscopy

    International Nuclear Information System (INIS)

    Martinson, I.

    1982-01-01

    A review is given of recent studies of atomic structure (in particular atomic spectra, energy levels and transition probabilities) using fast beams from ion accelerators. Thanks to improved spectral resolution detailed and quite accurate studies of energy levels are now possible, a number of such results will be discussed. The non-autoionizing, multiply excited levels in atoms and ions (including negative ions) are being vigorously investigated at present, some new results will be reported. The accuracy in lifetime determinations continues to improve, and several new ways for reduction of cascading effects have been developed. Some selected examples of recent progress in lifetime measurements are also included. (orig.)

  15. Progress of nuclide tracing technique in the study of soil erosion in recent decade

    International Nuclear Information System (INIS)

    Liu Gang; Yang Mingyi; Liu Puling; Tian Junliang

    2007-01-01

    In the last decade nuclide tracing technique has been widely employed in the investigation of soil erosion, which makes the studies of soil erosion into a new and rapid development period. This paper tried to review the recent progress of using 137 Cs, 210 Pb ex , 7 Be, composite tracers and REE-INAA in soil erosion rate, sedimentation rate, sediment source and soil erosion processes study, and also the existing research results. The trends for future development and questions are also discussed. (authors)

  16. Radiation and biophysical studies on cells and viruses. Progress report, April 1, 1976--June 30, 1977

    International Nuclear Information System (INIS)

    Cole, A.

    1977-01-01

    Progress is reported on the following research projects: genetic structure of DNA, chromosomes, and nucleoproteins; particle beam studies of radiosensitive sites; division delay in CHO cells induced by partly penetrating alpha particles; location of cellular sites for mutation induction; sites for radioinduced cell transformation using partly penetrating particle beams; gamma-ray and particle irradiation of nucleoproteins and other model systems; quantitation of surface antigens on normal and neoplastic cells by x-ray fluorescence; hyperthermic effects on cell survival and DNA repair mechanisms; and studies on radioinduced cell transformation

  17. Thermionic cogeneration burner assessment study. Third quarterly technical progress report, April-June, 1983

    Energy Technology Data Exchange (ETDEWEB)

    1983-01-01

    The specific tasks of this study are to mathematically model the thermionic cogeneration burner, experimentally confirm the projected energy flows in a thermal mock-up, make a cost estimate of the burner, including manufacturing, installation and maintenance, review industries in general and determine what groups of industries would be able to use the electrical power generated in the process, select one or more industries out of those for an in-depth study, including determination of the performance required for a thermionic cogeneration system to be competitive in that industry. Progress is reported. (WHK)

  18. Sustainable Design Approach: A case study of BIM use

    Directory of Open Access Journals (Sweden)

    Abdelhameed Wael

    2017-01-01

    The paper describes the methodology of this design approach through BIM strategies adopted in design creation. Case studies of architectural designs are used to highlight the details and benefits of this proposed approach.

  19. A Case Study in CAD Design Automation

    Science.gov (United States)

    Lowe, Andrew G.; Hartman, Nathan W.

    2011-01-01

    Computer-aided design (CAD) software and other product life-cycle management (PLM) tools have become ubiquitous in industry during the past 20 years. Over this time they have continuously evolved, becoming programs with enormous capabilities, but the companies that use them have not evolved their design practices at the same rate. Due to the…

  20. Preliminary Systems Design Study assessment report

    International Nuclear Information System (INIS)

    Mayberry, J.L.; Feizollahi, F.; Del Signore, J.C.

    1992-01-01

    The System Design Study (SDS), part of the Waste Technology Development Department at the Idaho National Engineering Laboratory (INEL), examined techniques for the remediation of hazardous and transuranic waste stored at Radioactive Waste Management Complex's Subsurface Disposal Area at the INEL. Using specific technologies, system concepts for treating the buried waste and the surrounding contaminated soil were evaluated. Evaluation included implementability, effectiveness, and cost. The SDS resulted in the development of technology requirements including demonstration, testing, and evaluation activities needed for implementing each concept. This volume contains introduction section containing a brief SDS background and lists the general assumptions and considerations used during the development of the system concepts. The introduction section is followed by sections describing two system concepts that produce a waste form in compliance with the Waste Isolation Pilot Plant (WIPP) Waste Acceptance Criteria (WAC) and transportation package (TRAMPAC) requirements. This system concept category is referred to as Waste Form 4, ''WIPP and TRAMPAC Acceptable.'' The following two system concepts are under this category: Sort, Treat, and Repackage System (4-BE-2); Volume Reduction and Packaging System (4-BE-4)