Quantitative application study on the control system of contract progress

International Nuclear Information System (INIS)

Hu Xiaocong; Kang Rujie; Zhan Li

2012-01-01

Quantitative application study on the control system of contract progress, which is based on project management theory and PDCA cycle methods, provides a new way for the contract business management of enterprise, in line with the current situation and the nuclear power enterprise performance management needs. The concept of the system, system development, program design and development of ERP (VBA design) which come from the work experience summary of business managers are convenient and feasible in practical applications. By way of the applications in 2009, 2010, 2011 three-year overhaul contract management and continuous adjustment it has become an important business management tool, which not only effectively guaranteed the contract time and efficiency, but also combines the performance management and contract progress management. This study has provided useful reference for the enterprise management. (authors)

Structured approach to design of diagnostic test evaluation studies for chronic progressive infections in animals

DEFF Research Database (Denmark)

Nielsen, Søren Saxmose; Toft, Nils; Gardner, Ian Andrew

2011-01-01

Diagnostic test evaluations (DTEs) for chronic infections are challenging because a protracted incubation period has to be considered in the design of the DTE, and the adverse effects of infection may be widespread and progressive over an animal's entire life. Frequently, the specific purpose......) than originally intended. The objective of this paper is to outline a structured approach to the design and conduct of a DTE for diagnostic tests used for chronic infections in animals, and intended for different purposes. We describe the process from reflections about test purpose and the underlying...... of the test is not formally considered when a test is evaluated. Therefore, the result is often a DTE where test sensitivity and specificity estimates are biased, either because of problems with establishing the true infection status or because the test detects another aspect of the infection (and analyte...

Progress of the ITER NBI acceleration grid power supply reference design

International Nuclear Information System (INIS)

Toigo, Vanni; Zanotto, Loris; Bigi, Marco; Decamps, Hans; Ferro, Alberto; Gaio, Elena; Gutiérrez, Daniel; Tsuchida, Kazuki; Watanabe, Kazuhiro

2013-01-01

Highlights: ► This paper reports the progress in the reference design of the Acceleration Grid Power Supply (AGPS) of the ITER Neutral Beam Injector (NBI) ► A critical revision of the main design choices is presented in light of the definition of some key interface parameters between the two AGPS subsystems. ► The verification of the fulfillment of the requirements in any operational conditions is reported and discussed. -- Abstract: This paper reports the progress in the reference design of the Acceleration Grid Power Supply (AGPS) of the ITER Neutral Beam Injector (NBI). The design of the AGPS is very challenging, as it shall be rated to provide about 55 MW at 1 MV dc in quasi steady-state conditions; moreover, the procurement of the system is shared between the European Domestic Agency (F4E) and the Japanese Domestic Agency (JADA), resulting in additional design complication due to the need of a common definition of the interface parameters. A critical revision of the main design choices is presented also in light of the definition of some key interface parameters between the two AGPS subsystems. Moreover, the verification of the fulfillment of the requirements in any operational conditions taking into account the tolerance of the different parameters is also reported and discussed

Progress report on LOFT rake designs

International Nuclear Information System (INIS)

Bearden, R.G.

1977-01-01

Evaluation of data from Loss-of-Fluid Test (LOFT) nonnuclear tests has shown a need for profile measurements at several locations in the LOFT piping. A prototype rake consisting of three Drag-Disc Turbine Transducers (DTT) has been designed and fabricated for installation at one location (FE-BL-1) in the blowdown loop. After successful operation during a LOFT nonnuclear test (L1-4) scheduled for May, 1977, additional rakes will be installed in the primary and blowdown loops. A research program to develop a pitot tube rake for measurement of steady state and transient two-phase flows is in progress at McMaster University, Hamilton, Ontario. A rake of thermocouples and pitot tubes will be developed for installation near the emergency core coolant (ECC) injection points

Designation differences and academic career progression

Directory of Open Access Journals (Sweden)

Chris W. Callaghan

2015-05-01

Contribution/Value add: This study provides new insights into certain ‘crisis milestones’, or role conflicts or issues, that may need to be resolved or balanced before the career progression of academics can typically occur.

Numerical Investigation of Progressive Collapse Resistance for Seismically Designed RC Buildings

OpenAIRE

Marchiş, Adrian G.; Ioani, Adrian M.

2014-01-01

In this paper the progressive collapse behavior of a reinforced concrete framed building located in different seismic areas from Romania is investigated. The six-storey structure is designed for low (ag = 0.08 g), moderate (ag = 0.16 g) and high (ag = 0.24 g) seismic zone. Based on the GSA (2003) criteria, a nonlinear static analysis is conducted first in order to estimate the progressive collapse resistance of the models. It was shown that all the structures will collapse when subjected to i...

Accelerator research studies: Progress report, Task C

International Nuclear Information System (INIS)

1985-06-01

The major effort reported is the study of the feasibility of a 300 MW gyroklystron at ∼9 GHz, and substantial progress has been made. A four-cavity gyroklystron design has been shown to be capable of linear gain as high as 66 dB and to be marginally stable against oscillation in any mode. AM and PM sensitivities to fluctuation in system parameters have also been calculated in the regime of linear operation. Initial non-linear design calculations have also been carried out which include the effect of tapering the axial magnetic guide field over the length of a gyroklystron circuit. Although these calculations are preliminary they do indicate potential for significant efficiency enhancement by magnetic field shaping techniques

JSFR design progress related to development of safety design criteria for Generation IV sodium-cooled fast reactors. (1) Overview

International Nuclear Information System (INIS)

Kamide, Hideki; Ando, Masato; Ito, Takaya

2015-01-01

JAEA, JAPC and MFBR have been conducting design study for the Japan Sodium-cooled Fast Reactor (JSFR), which is a design concept aiming at future commercial use as sustainable electric power source. As the result of the design study and R and D activity related the innovative technologies incorporated in the design in the Fast Reactor Cycle Technology Development (FaCT) project up to 2010, basic design concept of JSFR was established and its development process to the commercialization including construction and operation of a demonstration version of JSFR was outlined. JSFR is a looptype next generation sodium-cooled fast reactor (SFR), which is aiming at achieving development targets of Generation IV reactors concerning sustainability, safety and reliability, economics and proliferation resistance and physical protection by introducing the innovative technologies such as shortened high-chromium steel piping. The output power is assumed for the design study as 1,500 MWe for the commercial version and 750 MWe for the demonstration version. In FaCT phase I up to 2010, in order to evaluate feasibility to achieve the development targets, the design study has been conducted on the main components and systems. Since 2011, in order to contribute to the development of safety design criteria (SDC) and safety design guideline (SDG), which include the lessons learned from the TEPCO's Fukushima Dai-ichi nuclear power plants accident, in the frame work of Generation IV International Forum (GIF), the design study is focusing on the design measures against severe external events such as earthquake and tsunami. At the same time, the design study is going into detail and paying much attention to the maintenance and repair to make surer its feasibility. This paper summarizes the design concept of the demonstration version of JSFR in which progress of design work was incorporated for the safety issues on SDC and SDG of a SFR. (author)

Failure: A Source of Progress in Maintenance and Design

Science.gov (United States)

Chaïb, R.; Taleb, M.; Benidir, M.; Verzea, I.; Bellaouar, A.

This approach, allows using the failure as a source of progress in maintenance and design to detect the most critical components in equipment, to determine the priority order maintenance actions to lead and direct the exploitation procedure towards the most penalizing links in this equipment, even define the necessary changes and recommendations for future improvement. Thus, appreciate the pathological behaviour of the material and increase its availability, even increase its lifespan and improve its future design. In this context and in the light of these points, the failures are important in managing the maintenance function. Indeed, it has become important to understand the phenomena of failure and degradation of equipments in order to establish an appropriate maintenance policy for the rational use of mechanical components and move to the practice of proactive maintenance [1], do maintenance at the design [2].

Nuclear challenges and progress in designing stellarator fusion power plants

International Nuclear Information System (INIS)

El-Guebaly, L.A.; Wilson, P.; Henderson, D.; Sawan, M.; Sviatoslavsky, G.; Tautges, T.; Slaybaugh, R.; Kiedrowski, B.; Ibrahim, A.

2008-01-01

Over the past 5-6 decades, stellarator power plants have been studied in the US, Europe, and Japan as an alternate to the mainline magnetic fusion tokamaks, offering steady-state operation and eliminating the risk of plasma disruptions. The earlier 1980s studies suggested large-scale stellarator power plants with an average major radius exceeding 20 m. The most recent development of the compact stellarator concept delivered ARIES-CS - a compact stellarator with 7.75 m average major radius, approaching that of tokamaks. For stellarators, the most important engineering parameter that determines the machine size and cost is the minimum distance between the plasma boundary and mid-coil. Accommodating the breeding blanket and necessary shield within this distance to protect the ARIES-CS superconducting magnet represents a challenging task. Selecting the ARIES-CS nuclear and engineering parameters to produce an economic optimum, modeling the complex geometry for 3D nuclear analysis to confirm the key parameters, and minimizing the radwaste stream received considerable attention during the design process. These engineering design elements combined with advanced physics helped enable the compact stellarator to be a viable concept. This paper provides a brief historical overview of the progress in designing stellarator power plants and a perspective on the successful integration of the nuclear activity into the final ARIES-CS configuration

Design progress of the solar UV-Vis-IR telescope (SUVIT) aboard SOLAR-C

Science.gov (United States)

Katsukawa, Y.; Ichimoto, K.; Suematsu, Y.; Hara, H.; Kano, R.; Shimizu, T.; Matsuzaki, K.

2013-09-01

We present a design progress of the Solar UV-Vis-IR Telescope (SUVIT) aboard the next Japanese solar mission SOLAR-C. SUVIT has an aperture diameter of ~1.4 m for achieving spectro-polarimetric observations with spatial and temporal resolution exceeding the Hinode Solar Optical Telescope (SOT). We have studied structural and thermal designs of the optical telescope as well as the optical interface between the telescope and the focal plane instruments. The focal plane instruments are installed into two packages, filtergraph and spectrograph packages. The spectropolarimeter is the instrument dedicated to accurate polarimetry in the three spectrum windows at 525 nm, 854 nm, and 1083 nm for observing magnetic fields at both the photospheric and chromospheric layers. We made optical design of the spectrograph accommodating the conventional slit spectrograph and the integral field unit (IFU) for two-dimensional coverage. We are running feasibility study of the IFU using fiber arrays consisting of rectangular cores.

Sensitivity of measuring the progress in financial risk protection to survey design and its socioeconomic and demographic determinants: A case study in Rwanda.

Science.gov (United States)

Lu, Chunling; Liu, Kai; Li, Lingling; Yang, Yuhong

2017-04-01

Reliable and comparable information on households with catastrophic health expenditure (HCHE) is crucial for monitoring and evaluating our progress towards achieving universal financial risk protection. This study aims to investigate the sensitivity of measuring the progress in financial risk protection to survey design and its socioeconomic and demographic determinants. Using the Rwanda Integrated Living Conditions Survey in 2005 and 2010/2011, we derived the level and trend of the percentage of the HCHE using out-of-pocket health spending data derived from (1) a health module with a two-week recall period and six (2005)/seven (2010/2011) survey questions (Method 1) and (2) a consumption module with a four-week/ten-/12-month recall period and 11(2005)/24 (2010/2011) questions (Method 2). Using multilevel logistic regression analysis, we investigated the household socioeconomic and demographic characteristics that affected the sensitivity of estimating the HCHE to survey design. We found that Method 1 generated a significantly higher HCHE estimate (9.2%, 95% confidence interval 8.4%-10.0%) than Method2 (7.4%, 6.6%-8.1%) in 2005 and lower estimate (5.6%, 5.2%-6.1%) than Method 2 (8.2%, 7.6%-8.7%) in 2010/2011. The estimated trends of the HCHE using the two methods were not consistent between the two years. A household's size, its income quintile, having no under-five children, and educational level of its head were positively associated with the consistency of its HCHE status when using the two survey methods. Estimates of the progress in financial risk protection, especially among the most vulnerable households, are sensitive to survey design. These results are robust to various thresholds of catastrophic health spending. Future work must focus on mitigating survey effects through the development of statistical tools. Copyright © 2017 Elsevier Ltd. All rights reserved.

Design and progress of the SPHINX in KAERI

International Nuclear Information System (INIS)

Kim, Hyung Rae; Kim, Hwan Teol; Song, Jin Ho; Kim, Hee Dong; Bae Yoon Yeong

2005-01-01

The SCWR (SuperCritical Water-cooled Reactor) is one of the six reactor candidates selected in the Gen-IV project, which aims at the development of new reactors with enhanced economy and safety. The SCWR is considered to be a feasible concept of new nuclear power plant if the existing technologies developed in fossil fuel fired plants and LWRs are incorporated together with additional researches on several disciplines such as materials, water chemistry, and safety. Among the research areas, heat transfer experiments under supercritical conditions are required for the proper prediction of thermal hydraulic phenomena, which are essential in the reactor core designs. A heat transfer test loop using carbon dioxide (CO 2 ) as a surrogate fluid has been constructed in KAERI. The test facility, named as SPHINX (Supercritical Pressure Heat transfer Investigation for NeXt generation), will be used for the study of heat transfer in a single tube, single rod, and rod bundle. The heat transfer correlations obtained from the SPHINX will be compared with the other correlations generated at Kyushu University and INL. This paper describes the design characteristics and progress of the SPHINX in KAERI. The construction of the facility is completed and a trial run is being conducted. The test and the data production are expected to start by April 2005

Design and progress of the SPHINX in KAERI

Energy Technology Data Exchange (ETDEWEB)

Kim, Hyung Rae; Kim, Hwan Teol; Song, Jin Ho; Kim, Hee Dong; Bae Yoon Yeong [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

2005-07-01

The SCWR (SuperCritical Water-cooled Reactor) is one of the six reactor candidates selected in the Gen-IV project, which aims at the development of new reactors with enhanced economy and safety. The SCWR is considered to be a feasible concept of new nuclear power plant if the existing technologies developed in fossil fuel fired plants and LWRs are incorporated together with additional researches on several disciplines such as materials, water chemistry, and safety. Among the research areas, heat transfer experiments under supercritical conditions are required for the proper prediction of thermal hydraulic phenomena, which are essential in the reactor core designs. A heat transfer test loop using carbon dioxide (CO{sub 2}) as a surrogate fluid has been constructed in KAERI. The test facility, named as SPHINX (Supercritical Pressure Heat transfer Investigation for NeXt generation), will be used for the study of heat transfer in a single tube, single rod, and rod bundle. The heat transfer correlations obtained from the SPHINX will be compared with the other correlations generated at Kyushu University and INL. This paper describes the design characteristics and progress of the SPHINX in KAERI. The construction of the facility is completed and a trial run is being conducted. The test and the data production are expected to start by April 2005.

Overview of Progress on the EU DEMO Reactor Magnet System Design

NARCIS (Netherlands)

Zani, L.; Bayer, C.; biancolini, M.E.; Bonifetto, R.; Nijhuis, Arend; Yagotintsev, K.

2016-01-01

The DEMO reactor is expected to be the first application of fusion for electricity generation in the near future. To this aim, conceptual design activities are progressing in Europe (EU) under the lead of the EUROfusion Consortium in order to drive on the development of the major tokamak systems. In

Study on severe fuel damage and in-vessel melt progression

International Nuclear Information System (INIS)

Kim, Hee Dong; Kim, Sang Baik; Lee, Gyu Jung

1992-06-01

In-vessel core melt progression describes the progression of the state of a reactor core from core uncovery up to reactor vessel melt through in uncovered accidents or through temperature stabilization in accidents recovered by core reflooding. Melt progression can be thought as two parts; early melt progression and late melt progression. Early phase of core melt progression includes the progression of core material melting and relocation, which mostly consist of metallic materials. On the other hand, the late phase of core melt progression involves ceramic material melt and relocation to the lower plenum and heat-up the reactor vessel lower head. A large number of information are available for the early melt progression through experiments such as SFD, DF, FLHT test and utilized in the severe accident analysis codes. However, understanding of the late phase melt progression phenomenology is based primary on TMI-2 core examinations and not much experimental information is available. Especilally, the great uncertainties exist in vessel failure mode, melt composition, mass, and temperature. Further research is planned to perform to reduce the uncertainties in understanding of core melt down accidents as parts of long term melt progression research program. A study on the core melt progression at KAERI has been being performed through the Severe Accident Research Program with USNRC. KAERI staff had participated in the PBF SFD experiments at INEL and analyses of experiments were performed using SCDAP code. Experiments of core melt program have not been carried out at KAERI yet. It is planned that further research on core melt down accidents will be performed, which is related to design of future generations of nuclear reactors as parts of long-term project for improvement of nuclear reactor safety. (Author)

Thermal Hydraulic design parameters study for severe accidents using neural networks

Energy Technology Data Exchange (ETDEWEB)

Roh, Chang Hyun; Chang, Soon Heung [Korea Advanced Institute of Science and Technology, Taejon (Korea, Republic of); Chang, Keun Sun [Sunmoon University, Asan (Korea, Republic of)

1998-12-31

To provide the information on severe accident progression is very important for advanced or new type of nuclear power plant (NPP) design. A parametric study, therefore, was performed to investigate the effect of thermal hydraulic design parameters on severe accident progression of pressurized water reactors (PWRs). Nine parameters, which are considered important in NPP design or severe accident progression, were selected among the various thermal hydraulic design parameters. The backpropagation neural network (BPN) was used to determine parameters, which might more strongly affect the severe accident progression, among nine parameters. For training, different input patterns were generated by the latin hypercube sampling (LHS) technique and then different target patterns that contain core uncovery time and vessel failure time were obtained for Young Gwang Nuclear (YGN) Units 3 and 4 using modular accident analysis program (MAAP) 3.0B code. Three different severe accident scenarios, such as two loss of coolant accidents (LOCAs) and station blackout (SBO), were considered in this analysis. Results indicated that design parameters related to refueling water storage tank (RWST), accumulator and steam generator (S/G) have more dominant effects on the progression of severe accidents investigated, compared to the other six parameters. 9 refs., 5 tabs. (Author)

Thermal Hydraulic design parameters study for severe accidents using neural networks

Energy Technology Data Exchange (ETDEWEB)

Roh, Chang Hyun; Chang, Soon Heung [Korea Advanced Institute of Science and Technology, Taejon (Korea, Republic of); Chang, Keun Sun [Sunmoon University, Asan (Korea, Republic of)

1997-12-31

To provide the information on severe accident progression is very important for advanced or new type of nuclear power plant (NPP) design. A parametric study, therefore, was performed to investigate the effect of thermal hydraulic design parameters on severe accident progression of pressurized water reactors (PWRs). Nine parameters, which are considered important in NPP design or severe accident progression, were selected among the various thermal hydraulic design parameters. The backpropagation neural network (BPN) was used to determine parameters, which might more strongly affect the severe accident progression, among nine parameters. For training, different input patterns were generated by the latin hypercube sampling (LHS) technique and then different target patterns that contain core uncovery time and vessel failure time were obtained for Young Gwang Nuclear (YGN) Units 3 and 4 using modular accident analysis program (MAAP) 3.0B code. Three different severe accident scenarios, such as two loss of coolant accidents (LOCAs) and station blackout (SBO), were considered in this analysis. Results indicated that design parameters related to refueling water storage tank (RWST), accumulator and steam generator (S/G) have more dominant effects on the progression of severe accidents investigated, compared to the other six parameters. 9 refs., 5 tabs. (Author)

Wolsong 2, 3, and 4 quarterly progress review report on NSSS design and engineering

Energy Technology Data Exchange (ETDEWEB)

Jung, Sung Hoon; Kim, Sun Kee; Park, Tae Keun [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

1995-01-01

This is the Quarterly Progress Review Report for Wolsong NPP 2, 3 and 4 NSSS Design and Engineering which evaluates the performance of the project and describes the project highlight, manpower loading status, design and engineering and project related meetings by quarterly basis. 29 figs., 16 tabs. (Author).

A framework for prospectively defining progression rules for internal pilot studies monitoring recruitment.

Science.gov (United States)

Hampson, Lisa V; Williamson, Paula R; Wilby, Martin J; Jaki, Thomas

2017-01-01

Just over half of publicly funded trials recruit their target sample size within the planned study duration. When recruitment targets are missed, the funder of a trial is faced with the decision of either committing further resources to the study or risk that a worthwhile treatment effect may be missed by an underpowered final analysis. To avoid this challenging situation, when there is insufficient prior evidence to support predicted recruitment rates, funders now require feasibility assessments to be performed in the early stages of trials. Progression criteria are usually specified and agreed with the funder ahead of time. To date, however, the progression rules used are typically ad hoc. In addition, rules routinely permit adaptations to recruitment strategies but do not stipulate criteria for evaluating their effectiveness. In this paper, we develop a framework for planning and designing internal pilot studies which permit a trial to be stopped early if recruitment is disappointing or to continue to full recruitment if enrolment during the feasibility phase is adequate. This framework enables a progression rule to be pre-specified and agreed upon prior to starting a trial. The novel two-stage designs stipulate that if neither of these situations arises, adaptations to recruitment should be made and subsequently evaluated to establish whether they have been successful. We derive optimal progression rules for internal pilot studies which minimise the expected trial overrun and maintain a high probability of completing the study when the recruitment rate is adequate. The advantages of this procedure are illustrated using a real trial example.

The scheme machine: A case study in progress in design derivation at system levels

Science.gov (United States)

Johnson, Steven D.

1995-01-01

The Scheme Machine is one of several design projects of the Digital Design Derivation group at Indiana University. It differs from the other projects in its focus on issues of system design and its connection to surrounding research in programming language semantics, compiler construction, and programming methodology underway at Indiana and elsewhere. The genesis of the project dates to the early 1980's, when digital design derivation research branched from the surrounding research effort in programming languages. Both branches have continued to develop in parallel, with this particular project serving as a bridge. However, by 1990 there remained little real interaction between the branches and recently we have undertaken to reintegrate them. On the software side, researchers have refined a mathematically rigorous (but not mechanized) treatment starting with the fully abstract semantic definition of Scheme and resulting in an efficient implementation consisting of a compiler and virtual machine model, the latter typically realized with a general purpose microprocessor. The derivation includes a number of sophisticated factorizations and representations and is also deep example of the underlying engineering methodology. The hardware research has created a mechanized algebra supporting the tedious and massive transformations often seen at lower levels of design. This work has progressed to the point that large scale devices, such as processors, can be derived from first-order finite state machine specifications. This is roughly where the language oriented research stops; thus, together, the two efforts establish a thread from the highest levels of abstract specification to detailed digital implementation. The Scheme Machine project challenges hardware derivation research in several ways, although the individual components of the system are of a similar scale to those we have worked with before. The machine has a custom dual-ported memory to support garbage collection

Experimental studies on the Auburn Torsatron: Annual progress report

International Nuclear Information System (INIS)

Gandy, R.F.; Swanson, D.G.

1988-10-01

This paper discusses research programs in progress on the Auburn Torsatron. Topic areas covered are: ICR heating results; Compact Auburn Torsatron design; Compact Auburn Torsatron construction; and collaborations

The DIAN-TU Next Generation Alzheimer’s prevention trial: adaptive design and disease progression model

Science.gov (United States)

Bateman, Randall J.; Benzinger, Tammie L.; Berry, Scott; Clifford, David B.; Duggan, Cynthia; Fagan, Anne M.; Fanning, Kathleen; Farlow, Martin R.; Hassenstab, Jason; McDade, Eric M.; Mills, Susan; Paumier, Katrina; Quintana, Melanie; Salloway, Stephen P.; Santacruz, Anna; Schneider, Lon S.; Wang, Guoqiao; Xiong, Chengjie

2016-01-01

INTRODUCTION The Dominantly Inherited Alzheimer Network Trials Unit (DIAN-TU) trial is an adaptive platform trial testing multiple drugs to slow or prevent the progression of Alzheimer’s disease in autosomal dominant Alzheimer’s disease (ADAD) families. With completion of enrollment of the first two drug arms, the DIAN-TU now plans to add new drugs to the platform, designated as the Next Generation Prevention Trial (NexGen). METHODS In collaboration with ADAD families, philanthropic organizations, academic leaders, the DIAN-TU Pharma Consortium, the NIH, and regulatory colleagues, the DIAN-TU developed innovative clinical study designs for the DIAN-TU NexGen trial. RESULTS Our expanded trials toolbox consists of a Disease Progression Model for ADAD, primary endpoint DIAN-TU cognitive performance composite, biomarker development, self-administered cognitive assessments, adaptive dose adjustments, and blinded data collection through the last participant completion. CONCLUSION These steps represent elements to improve efficacy of the adaptive platform trial and a continued effort to optimize prevention and treatment trials in ADAD. PMID:27583651

Effects of curriculum organisation on study progress in engineering studies

NARCIS (Netherlands)

Hulst, M. van der; Jansen, E.

2002-01-01

Procrastination and time investment are important issues in the study of student performance and progress. Previous research on these issues has mainly concentrated upon individual differences between students in personality and time management skills. However, study progress depends not only on

Effects of curriculum organisation on study progress in engineering studies

NARCIS (Netherlands)

van der Hulst, M.; Jansen, E.P.W.A.

Procrastination and time investment are important issues in the study of student performance and progress. Previous research on these issues has mainly concentrated upon individual differences between students in personality and time management skills. However, study progress depends not only on

The FCC-ee study: Progress and challenges

CERN Document Server

Koratzinos, Michael; Bogomyagkov, Anton; Boscolo, Manuela; Cook, Charlie; Doblhammer, Andreas; Härer, Bastian; Tomás, Rogelio; Levichev, Evgeny; Medina Medrano, Luis; Shatilov, Dmitry; Wienands, Ulrich; Zimmermann, Frank

The FCC (Future Circular Collider) study represents a vision for the next large project in high energy physics, comprising an 80-100 km tunnel that can house a future 100 TeV hadron collider. The study also includes a high luminosity e+e- collider operating in the centre-of-mass energy range of 90-350 GeV as a possible intermediate step, the FCC-ee. The FCC-ee aims at definitive electro-weak precision measurements of the Z, W, H and top particles, and search for rare phenomena. Although FCC-ee is based on known technology, the goal performance in luminosity and energy calibration make it quite challenging. During 2014 the study went through an exploration phase. The study has now entered its second year and the aim is to produce a conceptual design report during the next three to four years. We here report on progress since the last IPAC conference.

ITER - Progress in design and validating R and D. Note by the Director. ITER meeting, Moscow, 28 June 2000

International Nuclear Information System (INIS)

2001-01-01

This note summarises, for the ITER Council, material presented in detail to TAC, in the report ''Progress in Resolving Open Design Issues from the ODR'', including: further investigation of physics issues raised in the TAC report or in the course of the Parties' domestic assessments; and features of the ITER design which reflect a resolution of choice of options. In addition, the note summarises and illustrates recent progress in the programme of validating technology R and D, as presented in the report to TAC, ''ITER Technology R and D Progress Report''

Design and R and D progress of Korean HCCR TBM

Energy Technology Data Exchange (ETDEWEB)

Cho, Seungyon, E-mail: sycho@nfri.re.kr [National Fusion Research Institute, Daejeon (Korea, Republic of); Ahn, Mu-Young [National Fusion Research Institute, Daejeon (Korea, Republic of); Lee, Dong Won [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Park, Yi-Hyun [National Fusion Research Institute, Daejeon (Korea, Republic of); Lee, Eo Hwak; Jin, Hyung Gon; Lee, Cheol Woo; Kim, Tae Kyu; Chun, Young-Bum; Kim, Suk Kwon; Yoon, Jae Sung [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Yun, Young-Hoon [Dongshin University, Naju (Korea, Republic of); Jung, Yang Il [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Lee, Young-Min [National Fusion Research Institute, Daejeon (Korea, Republic of); Shin, Kyu In [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Ku, Duck Young; Park, Soon Chang; Kim, Chang-Shuk; Min, Kyungmi [National Fusion Research Institute, Daejeon (Korea, Republic of); Jeong, Yong Hwan [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); and others

2014-10-15

Korea plans to test a Helium Cooled Ceramic Reflector (HCCR) Test Blanket Module (TBM) in ITER. The HCCR TBM adopts a four sub-module concept considering the fabricability and the transfer of irradiated TBM for post irradiation examination. Each sub-module has seven-layer breeding zone, including three neutron multiplier layers packed with beryllium pebbles, three lithium ceramic pebble bed packed tritium breeder layers, and a reflector layer packed with graphite pebbles. Based on this configuration, neutronic and electromagnetic calculations were performed and their results were applied for the conceptual design of HCCR TBM that considers manufacturing feasibility. Also, a design and safety analysis of HCCR Test Blanket System (TBS) was performed using integrated design tools modifying nuclear system codes for helium coolant and tritium behavior evaluation. The Advanced Reduced Activation Alloy (ARAA) is being developed as a structural material. A total of 73 candidate ARAA alloys were designed and their out-of-pile performance was evaluated. The graphite pebbles as the neutron reflector were fabricated by using mechanical machining and grounding method with the surface coated with SiC. The hydrogen permeation characteristics of structural materials were evaluated using the Hydrogen PERmeation (HYPER) facility. The recent design and R and D progress on these areas are addressed in this paper.

JSFR design progress related to development of safety design criteria for generation IV sodium-cooled fast reactors. (3) Progress of component design

International Nuclear Information System (INIS)

Enuma, Yasuhiro; Kawasaki, Nobuchika; Orita, Junichi; Eto, Masao; Miyagawa, Takayuki

2015-01-01

In the frame work of generation IV international forum (GIF), safety design criteria (SDC) and safety design guideline (SDG) for the generation IV sodium-cooled fast reactors have been developing in the circumstance of worldwide deployment of SFRs. JAEA, JAPC, MFBR have been investigating design study for JSFR to satisfy SDC in the feasibility study of SDG for Sodium-cooled Fast Reactor (SFR). In addition to the safety measures, maintainability, reparability and manufacturability are taken into account in the JSFR design study. This paper describes the design of main components. Enlargement of the access route for the inspection devices and addition of the access routes were carried out for the reactor structure. The pump-integrated IHX (pump/IHX) was modified for the primary heat exchanger (PHX), which was installed for the decay heat removal in the IHX at the upper plenum, to be removable for improved repair and maintenance. For the steam generator (SG), protective wall tube type design is under investigation as an option with less R and D risks. (author)

Academic dismissal policy for medical students : effect on study progress and help-seeking behaviour

NARCIS (Netherlands)

Stegers-Jager, Karen M.; Cohen-Schotanus, Janke; Splinter, Ted A. W.; Themmen, Axel P. N.

2011-01-01

CONTEXT Medical students often fail to finish medical school within the designated time. An academic dismissal (AD) policy aims to enforce satisfactory progress and to enable early identification and timely support or referral of struggling students. In this study, we assessed whether the

Conceptual design main progress of EAST Articulated Maintenance Arm (EAMA) system

Energy Technology Data Exchange (ETDEWEB)

Shi, Shanshuang, E-mail: shiss@ipp.ac.cn [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei 230031 (China); Laboratory of Intelligent Machines, Lappeenranta University of Technology (Finland); Song, Yuntao; Cheng, Yong [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei 230031 (China); Villedieu, Eric; Bruno, Vincent [CEA-IRFM, F-13108 Saint-Paul-Lez-Durance (France); Feng, Hansheng [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei 230031 (China); Wu, Huapeng [Laboratory of Intelligent Machines, Lappeenranta University of Technology (Finland); Wang, Peng [State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000 (China); Hao, Zhiwei; Li, Yang; Wang, Kun; Pan, Hongtao [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei 230031 (China)

2016-03-15

Highlights: • EAST Articulated Maintenance Arm (EAMA) system is being collaboratively developed by ASIPP and CEA-IRFM. • Conceptual design for a 3-DOF wrist end effector with gripper has been finished. • Kinematic design can reach 90% of the workspace inside EAST tokamak vessel. • A prototype of EAMA arm segment has been built to validate the design. - Abstract: EAST articulated maintenance arm (EAMA) system is being collaboratively developed by ASIPP and CEA-IRFM for the purpose of remote inspection and simple maintenance operations in EAST vacuum vessel during physical experiments without breaking the ultra-high vacuum condition. The EAMA system design is based on a similar articulated inspection arm robot successfully demonstrated in Tore Supra in 2008. In order to better meet EAST configurations and maintenance requirements, optimized mechanisms and dimensions are considered for EAMA robot as upgrades. Besides, the segmented arm is equipped with a 3-DOF wrist end effector and gripper for gripping operation as well as inspection. Some calculations and simulations on statics, kinematics and workspace of EAMA have been presented to validate the feasibility. This paper introduces the overall design of the EAMA robot and presents implementation progress.

Conceptual design main progress of EAST Articulated Maintenance Arm (EAMA) system

International Nuclear Information System (INIS)

Shi, Shanshuang; Song, Yuntao; Cheng, Yong; Villedieu, Eric; Bruno, Vincent; Feng, Hansheng; Wu, Huapeng; Wang, Peng; Hao, Zhiwei; Li, Yang; Wang, Kun; Pan, Hongtao

2016-01-01

Highlights: • EAST Articulated Maintenance Arm (EAMA) system is being collaboratively developed by ASIPP and CEA-IRFM. • Conceptual design for a 3-DOF wrist end effector with gripper has been finished. • Kinematic design can reach 90% of the workspace inside EAST tokamak vessel. • A prototype of EAMA arm segment has been built to validate the design. - Abstract: EAST articulated maintenance arm (EAMA) system is being collaboratively developed by ASIPP and CEA-IRFM for the purpose of remote inspection and simple maintenance operations in EAST vacuum vessel during physical experiments without breaking the ultra-high vacuum condition. The EAMA system design is based on a similar articulated inspection arm robot successfully demonstrated in Tore Supra in 2008. In order to better meet EAST configurations and maintenance requirements, optimized mechanisms and dimensions are considered for EAMA robot as upgrades. Besides, the segmented arm is equipped with a 3-DOF wrist end effector and gripper for gripping operation as well as inspection. Some calculations and simulations on statics, kinematics and workspace of EAMA have been presented to validate the feasibility. This paper introduces the overall design of the EAMA robot and presents implementation progress.

IFMIF High Flux Test Module-Recent progress in design and manufacturing

International Nuclear Information System (INIS)

Leichtle, D.; Arbeiter, F.; Dolensky, B.; Fischer, U.; Gordeev, S.; Heinzel, V.; Ihli, T.; Lang, K.-H.; Moeslang, A.; Simakov, S.P.; Slobodchuk, V.; Stratmanns, E.

2008-01-01

The International Fusion Material Irradiation Facility (IFMIF) is an accelerator driven neutron source for irradiation tests of candidate fusion reactor materials. Within the High Flux Test Module (HFTM) a testing volume of 0.5 l filled by qualified small scale specimens will be irradiated at displacement rates of 20-50 dpa/fpy in structural materials. The Forschungszentrum Karlsruhe (FZK) has developed a HFTM design which closely follows the design premise of maximising the space available for irradiation specimens in the IFMIF high flux zone and in addition allows keeping the temperature nearly constant in the rigs containing the specimen. Complementary analyses on nuclear, thermo-hydraulics and mechanical performance of the HFTM were performed to optimize the design. The present paper highlights the main design characteristics as well as recent progress achieved in this area. The contribution also includes (i) recommendations for the use of container, rig and capsule materials, and (ii) a description of the fabrication routes for the entire HFTM including brazing and filling procedures which are currently under development at the Forschungszentrum Karlsruhe

IFMIF High Flux Test Module-Recent progress in design and manufacturing

Energy Technology Data Exchange (ETDEWEB)

Leichtle, D. [Association FZK-EURATOM, Forschungszentrum Karlsruhe, Institut fuer Reaktorsicherheit, Hermann-von-Helmholtz-Platz 1, D-76344 Eggenstein-Leopoldshafen (Germany)], E-mail: leichtle@irs.fzk.de; Arbeiter, F.; Dolensky, B.; Fischer, U.; Gordeev, S.; Heinzel, V.; Ihli, T.; Lang, K.-H. [Association FZK-EURATOM, Forschungszentrum Karlsruhe, Institut fuer Reaktorsicherheit, Hermann-von-Helmholtz-Platz 1, D-76344 Eggenstein-Leopoldshafen (Germany); Moeslang, A. [Association FZK-EURATOM, Forschungszentrum Karlsruhe, Institut fuer Materialforschung, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen (Germany); Simakov, S.P.; Slobodchuk, V.; Stratmanns, E. [Association FZK-EURATOM, Forschungszentrum Karlsruhe, Institut fuer Reaktorsicherheit, Hermann-von-Helmholtz-Platz 1, D-76344 Eggenstein-Leopoldshafen (Germany)

2008-12-15

The International Fusion Material Irradiation Facility (IFMIF) is an accelerator driven neutron source for irradiation tests of candidate fusion reactor materials. Within the High Flux Test Module (HFTM) a testing volume of 0.5 l filled by qualified small scale specimens will be irradiated at displacement rates of 20-50 dpa/fpy in structural materials. The Forschungszentrum Karlsruhe (FZK) has developed a HFTM design which closely follows the design premise of maximising the space available for irradiation specimens in the IFMIF high flux zone and in addition allows keeping the temperature nearly constant in the rigs containing the specimen. Complementary analyses on nuclear, thermo-hydraulics and mechanical performance of the HFTM were performed to optimize the design. The present paper highlights the main design characteristics as well as recent progress achieved in this area. The contribution also includes (i) recommendations for the use of container, rig and capsule materials, and (ii) a description of the fabrication routes for the entire HFTM including brazing and filling procedures which are currently under development at the Forschungszentrum Karlsruhe.

Assessment on the Prevention of Progression by Rosiglitazone on Atherosclerosis in diabetes patients with Cardiovascular History (APPROACH): study design and baseline characteristics.

Science.gov (United States)

Ratner, Robert E; Cannon, Christopher P; Gerstein, Hertzel C; Nesto, Richard W; Serruys, Patrick W; Van Es, Gerrit-Anne; Kolatkar, Nikheel S; Kravitz, Barbara G; Zalewski, Andrew; Fitzgerald, Peter J

2008-12-01

Rosiglitazone, a thiazolidinedione, has effects on insulin sensitivity and cardiovascular risk factors that may favorably impact the progression of coronary atherosclerosis. APPROACH is a double-blind randomized clinical trial comparing the effects of the insulin sensitizer rosiglitazone with the insulin secretagogue glipizide on the progression of coronary atherosclerosis. Patients with type 2 diabetes and coronary artery disease undergoing clinically indicated coronary angiography or percutaneous coronary intervention are randomized to receive rosiglitazone or glipizide for 18 months using a titration algorithm designed to provide comparable glycemic control between treatment groups. The primary end point is change in percent atheroma volume from baseline to study completion in a nonintervened coronary artery, as measured by intravascular ultrasound. Cardiovascular events are adjudicated by an end point committee. A total of 672 patients were randomized. The mean age was 61 years, hemoglobin A(1c) (HbA(1c)) 7.2%, body mass index 29.5 kg/m(2), and median duration of diabetes 4.8 years. At baseline, approximately half of the participants were receiving oral antidiabetic monotherapy (53.9%) with 27.5% receiving dual combination therapy and 17.9% treated with diet and exercise alone. Approximately two thirds of the participants (68%) had dyslipidemia, 79.9% hypertension, and 24% prior myocardial infarction. APPROACH has fully enrolled a high-risk patient population and will compare the glucose-independent effects of rosiglitazone and glipizide on the progression of coronary atherosclerosis, as well as provide additional data on the cardiovascular safety of rosiglitazone in patients with type 2 diabetes and coronary artery disease.

The Natural History of the Progression of Atrophy Secondary to Stargardt Disease (ProgStar) Studies: Design and Baseline Characteristics: ProgStar Report No. 1.

Science.gov (United States)

Strauss, Rupert W; Ho, Alex; Muñoz, Beatriz; Cideciyan, Artur V; Sahel, José-Alain; Sunness, Janet S; Birch, David G; Bernstein, Paul S; Michaelides, Michel; Traboulsi, Elias I; Zrenner, Eberhart; Sadda, SriniVas; Ervin, Ann-Margret; West, Sheila; Scholl, Hendrik P N

2016-04-01

To describe the design and baseline characteristics of patients enrolled into 2 natural history studies of Stargardt disease (STGD1). Multicenter retrospective and prospective cohort studies. Three hundred sixty-five unique patients aged 6 years and older at baseline harboring disease-causing variants in the ABCA4 gene and with specified ocular lesions were enrolled from 9 centers in the United States and Europe. In the retrospective study, patients contributed medical record data from at least 2 and up to 4 visits for at least 1 examination modality: fundus autofluorescence (FAF), spectral-domain (SD) optical coherence tomography (SD OCT), and/or microperimetry (MP). The total observational period was at least 2 years and up to 5 years between single visits. Demographic and visual acuity (VA) data also were obtained. In the prospective study, eligible patients were examined at baseline using a standard protocol, with 6-month follow-up visits planned for a 2-year period for serial Early Treatment Diabetic Retinopathy Study (ETDRS) best-corrected VA, SD OCT, FAF, and MP. Design and rationale of a multicenter study to determine the progression of STGD1 in 2 large retrospective and prospective international cohorts. Detailed baseline characteristics of both cohorts are presented, including demographics, and structural and functional retinal metrics. Into the retrospective study, 251 patients (458 eyes) were enrolled; mean follow-up ± standard deviation was 3.9±1.6 years. At baseline, 36% had no or mild VA loss, and 47% of the study eyes had areas of definitely decreased autofluorescence (DDAF) with an average lesion area of 2.5±2.9 mm(2) (range, 0.02-16.03 mm(2)). Two hundred fifty-nine patients (489 eyes) were enrolled in the prospective study. At baseline, 20% had no or mild VA loss, and 64% had areas of DDAF with an average lesion area of 4.0±4.4 mm(2) (range, 0.03-24.24 mm(2)). The mean retinal sensitivity with MP was 10.8±5.0 dB. The ProgStar cohorts have

Progresses in proton radioactivity studies

Energy Technology Data Exchange (ETDEWEB)

Ferreira, L. S., E-mail: flidia@ist.utl.pt [Center of Physics and Engineering of Advanced Materials, CeFEMA and Departamento de Física, Instituto Superior Técnico, Universidade de Lisboa, Avenida Rovisco Pais, P1049-001 Lisbon (Portugal); Maglione, E. [Dipartimento di Fisica e Astronomia “G. Galilei”, Via Marzolo 8, I-35131 Padova, Italy and Istituto Nazionale di Fisica Nucleare, Padova (Italy)

2016-07-07

In the present talk, we will discuss recent progresses in the theoretical study of proton radioactivity and their impact on the present understanding of nuclear structure at the extremes of proton stability.

The Correction of Myopia Evaluation Trial: lessons from the study design.

Science.gov (United States)

Hyman, L; Gwiazda, J

2004-01-01

The Correction of Myopia Evaluation Trial (COMET), a multicentre clinical trial based in 4 schools of optometry in the United States, evaluated the effect of progressive addition lenses versus single vision lenses on myopia progression in an ethnically diverse group of 469 myopic children aged 6 to 11 years. Completion of the clinical trial phase of the study provides an opportunity to evaluate aspects of the study design that contribute to its success. This article describes aspects of the study design that were influential in ensuring the smooth conduct of COMET. These include a dedicated team of investigators, an organisational structure with strong leadership and an independent Co-ordinating Centre, regular communication among investigators, flexible and creative approaches to recruitment and retention, sensitivity to concerns for child safety and child participation, and methods for enhancing and monitoring data reliability. The experience with COMET has provided a number of valuable lessons for all aspects of the study design that should benefit the development and implementation of future clinical trials, particularly those done in similar populations of children. The use of a carefully designed protocol using standard methods by dedicated members of the study team is essential in ensuring achievement of the study aims.

Progress in design and integration of the ITER Electron Cyclotron H and CD system

International Nuclear Information System (INIS)

Darbos, C.; Henderson, M.; Albajar, F.; Bigelow, T.; Bonicelli, T.; Chavan, R.; Denisov, G.G.; Fasel, D.; Heidinger, R.; Hogge, J.P.; Kobayashi, N.; Piosczyk, B.; Rao, S.L.; Rasmussen, D.; Saibene, G.; Sakamoto, K.; Takahashi, K.; Thumm, M.

2009-01-01

The Electron Cyclotron system for ITER is an in-kind procurement shared between five parties and the total installed power will be 24 MW, corresponding to a nominal injected power of 20 MW to the plasma, with a possible upgrade up to 48 MW (corresponding to 40 MW injected). Some critical issues have been raised and changes are proposed to simplify these procurements and to facilitate the integration into ITER. The progress in the design and the integration of the EC system into the whole project is presented in this paper, as well as some issues still under studies and some recommendations made by external expert committees.

Fathers' experience of childbirth when non-progressive labour occurs and augmentation is established. A qualitative study

DEFF Research Database (Denmark)

Hasman, Kirsten; Kjaergaard, Hanne; Esbensen, Bente Appel

2014-01-01

as uncontrollable processes and (3) Relief about the decision of augmentation. The fathers had a rational approach and felt powerless when the process of labour was uncontrollable. They felt they were not able to help their partners in pain when non-progressive labour occurred. They experienced relief when......OBJECTIVE: Augmentation with oxytocin during labour has increased in Western obstetrics over the last few decades. The aim of this study was to describe how fathers experienced childbirth when non-progressive labour occurred and augmentation was established. METHOD: A qualitative descriptive design...... after experiencing the non-progressive labour, need directions from the midwives to carry out appropriate and usefull tasks....

NRC review of passive reactor design certification testing programs: Overview, progress, and regulatory perspective

Energy Technology Data Exchange (ETDEWEB)

Levin, A.E.

1995-09-01

New reactor designs, employing passive safety systems, are currently under development by reactor vendors for certification under the U.S. Nuclear Regulatory Commission`s (NRC`s) design certification rule. The vendors have established testing programs to support the certification of the passive designs, to meet regulatory requirements for demonstration of passive safety system performance. The NRC has, therefore, developed a process for the review of the vendors` testing programs and for incorporation of the results of those reviews into the safety evaluations for the passive plants. This paper discusses progress in the test program reviews, and also addresses unique regulatory aspects of those reviews.

Cabling design of booster and storage ring construction progress of TPS

International Nuclear Information System (INIS)

Wong, Y.-S.; Liu, K.-B.; Liu, C.-Y.; Wang, B.-S.

2017-01-01

The 2012 Taiwan Photon Source (TPS) cable construction project started after 10 months to complete the cable laying and installation of power supply. The circumference of the booster ring (BR) is 496.8 m, whereas that of the storage ring (SR) is 518.4 m. Beam current is set to 500 mA at 3.3 GeV. The paper on grounding systems discusses the design of the ground wire (< 0.2 Ω) with low impedance, power supply of the accelerator and cabling tray. The flow and size of the ground current are carefully evaluated to avoid grounded current from flowing everywhere, which causes interference problems. In the design of the TPS, special shielding will be established to isolate the effects of electromagnetic interference on the magnet and ground current. Booster ring dipoles are connected by a series of 54-magnet bending dipole; the cable size of its stranded wire measures 250 mm"2, with a total length of 5000 m. Booster ring and storage ring quadrupoles have 150 magnets; the cable size of their stranded wire is 250 mm"2, with a total length of 17000 m. Storage ring dipole consists of 48 magnets; the cable size of its stranded wire is 325 mm"2, with a total length of 6000 m. This study discusses the power supply cabling design of the storage ring and booster ring construction progress of TPS. The sections of this paper are divided into discussions of the construction of the control and instrument area, cabling layout of booster ring and storage ring, as well as the installation and commission machine. This study also discusses the use of a high-impedance meter to determine the effect of cabling insulation and TPS power supply machine on energy transfer to ensure the use of safe and correct magnet.

Progression to impaired glucose regulation and diabetes in the population-based Inter99 study

DEFF Research Database (Denmark)

Engberg, Susanne; Vistisen, Dorte; Lau, Cathrine

2009-01-01

Objective: To estimate the progression rates to impaired glucose regulation (impaired fasting glucose or impaired glucose tolerance) and diabetes in the Danish population-based Inter99 study and in a high-risk subpopulation, separately. Research Design and Methods: From a population-based primary...... glucose regulation using the current World Health Organization classification criteria were calculated for the first time in a large European population-based study. The progression rates to diabetes show the same pattern as seen in the few similar European studies....... prevention study, the Inter99 study, 4,615 individuals without diabetes at baseline and with relevant follow-up data were divided into a low- and a high-risk group based on a risk estimate of ischemic heart disease or the presence of risk factors (smoking, hypertension, hypercholesterolemia, obesity...... estimated directly from baseline to 5-year follow-up for all the participants, and from baseline through 1- and 3-, to 5-year follow-up for the high-risk individuals, separately. Results: In the combined low- and high-risk group, 2.1 per 100 person-years progressed from normal glucose tolerance to impaired...

Nuclear challenges and progress in designing stellarator power plants

International Nuclear Information System (INIS)

El-Guebaly, L.

2007-01-01

As an alternate to the mainline magnetic fusion tokamaks, the stellarator concept offers a steady state operation without external driven current, eliminating the risk of plasma irruptions. Over the past 2-3 decades, stellarator power plants have been studied in the U.S., Japan, and Europe to enhance the physics and engineering aspects and optimize the design parameters that are subject to numerous constraints. The earlier 1980's studies delivered large stellarators with an average major radius exceeding 20 m. The most recent development of the compact stellarator concept has led to the construction of the National Compact Stellarator Experiment (NCSX) in the U.S. and the 3 years power plant study of ARIES-CS, a compact stellarator with 7.75 m average major radius, approaching that of tokamaks. The ARIES-CS first wall configuration deviates from the standard practice of uniform toroidal shape in order to achieve compactness. Modeling such a complex geometry for 3-D nuclear analysis was a challenging engineering task. A novel approach based on coupling the CAD model with the MCNP Monte Carlo code was developed to model, for the first time ever, the complex stellarator geometry for nuclear assessments. The most important parameter that determines the stellarator size and cost is the minimum distance between the plasma boundary and mid-coil. Accommodating the breeding blanket and necessary shield to protect the superconducting magnet represented another challenging task. An innovative approach utilizing a non-uniform blanket combined with a highly efficient WC shield for this highly constrained area reduced the radial standoff (and machine size and cost) by 25- 30%, which is significant. As stellarators generate more radwaste than tokamaks, managing ARIES-CS active materials during operation and after plant decommissioning was essential for the environmental attractiveness of the machine. The geological disposal option could be replaced with more attractive scenarios

State‐of‐the‐art and progress in the optimization‐based simultaneous design and control for chemical processes

DEFF Research Database (Denmark)

Yuan, Zhihong; Chen, Bingzhen; Sin, Gürkan

2012-01-01

‐based frameworks that are capable of screening alternative designs, and (2) optimization‐based frameworks that integrate the process design and control system design. The major objective is to give an up‐to‐date review of the state‐of‐the‐art and progress in the challenging area of optimization‐based simultaneous...... design and control. First, motivations and significances of simultaneous design and control are illustrated. Second, a general classification of existing methodologies of optimization‐based simultaneous design and control is outlined. Subsequently, the mathematical formulations and relevant theoretical...

Design progress of cryogenic hydrogen system for China Spallation Neutron Source

Energy Technology Data Exchange (ETDEWEB)

Wang, G. P.; Zhang, Y.; Xiao, J.; He, C. C.; Ding, M. Y.; Wang, Y. Q.; Li, N.; He, K. [Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, P.R. (China)

2014-01-29

China Spallation Neutron Source (CSNS) is a large proton accelerator research facility with 100 kW beam power. Construction started in October 2011 and is expected to last 6.5 years. The cryogenic hydrogen circulation is cooled by a helium refrigerator with cooling capacity of 2200 W at 20 K and provides supercritical hydrogen to neutron moderating system. Important progresses of CSNS cryogenic system were concluded as follows. Firstly, process design of cryogenic system has been completed including helium refrigerator, hydrogen loop, gas distribution, and safety interlock. Secondly, an accumulator prototype was designed to mitigate pressure fluctuation caused by dynamic heat load from neutron moderation. Performance test of the accumulator has been carried out at room and liquid nitrogen temperature. Results show the accumulator with welding bellows regulates hydrogen pressure well. Parameters of key equipment have been identified. The contract for the helium refrigerator has been signed. Mechanical design of the hydrogen cold box has been completed, and the hydrogen pump, ortho-para hydrogen convertor, helium-hydrogen heat exchanger, hydrogen heater, and cryogenic valves are in procurement. Finally, Hydrogen safety interlock has been finished as well, including the logic of gas distribution, vacuum, hydrogen leakage and ventilation. Generally, design and construction of CSNS cryogenic system is conducted as expected.

Reactor Primary Coolant System Pipe Rupture Study. Progress report No. 32, July--December 1974

International Nuclear Information System (INIS)

1975-03-01

The pipe rupture study is designed to extend the understanding of failure-causing mechanisms and to provide improved capability for evaluating reactor piping systems to minimize the probability of failures. Following a detailed review to determine the effort most needed to improve nuclear system piping (Phase I), analytical and experimental efforts (Phase II) were started in 1965. This progress report summarizes the recent accomplishments of a broad program in (a) basic fatigue studies focused on Elastic/Plastic ASME Code Design Rules, (b) at-reactor tests of the effect of primary coolant environment on the fatigue behavior of piping steels, and (c) studies directed at quantifying weld sensitization in T-304 stainless steel. (auth)

Borehole cement and rock properties studies: progress report, October 1, 1976--September 30, 1977

International Nuclear Information System (INIS)

Roy, D.M.

1977-01-01

Research progress is reported in sections on properties of cements, permeability studies, cement-rock interactions, cement long range stability, waste-rock interactions, and properties of shale. Results suggest that present canister emplacement design is inadequate. Present data suggest that canisters should be placed to a depth at least as great as the width of the chamber opening. This means, with current geometry, burial of the top of the canister to 18 ft. depth. For certain materials, and with further study of the question, design requirements may prove even more stringent. Other aspects of the problem remain to be adequately considered; these aspects may be influential in affecting burial design criteria. These factors include general thermoelastic effects, fluid pressures, and effects of pre-existing discontinuities, as well as site-specific issues

Advances on ELIC Design Studies

International Nuclear Information System (INIS)

Bogacz, S. Alex; Bogacz, S.; Chevtsov, P.; Derbenev, Ya.; Evtushenko, P.; Krafft, G.; Hutton, A.; Li, R.; Merminga, L.; Musson, J.; Yunn, B.; Zhang, Y.; Sayed, H.; Qiang, J.

2008-01-01

A conceptual design of a ring-ring electron-ion collider based on CEBAF with a center-of-mass energy up to 90 GeV at luminosity up to 1035 cm-2s-1 has been proposed at JLab to fulfill science requirements. Here, we summarize design progress including collider ring and interaction region optics with chromatic aberration compensation. Electron polarization in the Figure-8 ring, stacking of ion beams in an accumulator-cooler ring, beam-beam simulations and a faster kicker for the circulator electron cooler ring are also discussed

Design study on advanced nuclear fuel recycle system. Conceptual design study of recycle system using molten salt

International Nuclear Information System (INIS)

Kasai, Y.; Kakehi, I.; Moro, T.; Higashi, T.; Tobe, K.; Kawamura, F.; Yonezawa, S.; Yoshiuji, T.

1998-10-01

Advanced recycle system engineering group of OEC (Oarai Engineering Center) has being carried out a design study of the advanced nuclear fuel recycle system using molten salt (electro-metallurgical process). This system is aiming for improvements of fuel cycle economy and reduction of environmental burden (MA recycles, Minimum of radioactive waste disposal), and also improvement of safety and nuclear non-proliferation. This report describes results of the design study that has been continued since December 1996. (1) A design concept of the advanced nuclear fuel recycle system, that is a module type recycles system of pyrochemical reprocessing and fuel re-fabrication was studied. The module system has advantage in balance of Pu recycle where modules are constructed in coincidence with the construction plan of nuclear power plants, and also has flexibility for technology progress. A demonstration system, minimum size of the above module, was studies. This system has capacity of 10 tHM/y and is able to demonstrate recycle technology of MOX fuel, metal fuel and nitride fuel. (2) Each process of the system, which are pyrochemical electrorefining system, cathode processor, de-cladding system, waste disposal system, etc., were studied. In this study, capacity of an electrorefiner was discussed, and vitrification experiment of molten salt using lead-boric acid glass was conducted. (3) A hot cell system and material handling system of the demonstration system was studied. A robot driven by linear motor was studied for the handling system, and an arrangement plan of the cell system was made. Criticality analysis in the cell system and investigation of material accountancy system of the recycle plant were also made. This design study will be continued in coincidence with design study of reactor and fuel, aiming to establish the concept of FBR recycle system. (author)

Progress on the Design of the Storage Ring Vacuum System for the Advanced Photon Source Upgrade Project

Energy Technology Data Exchange (ETDEWEB)

Stillwell, B.; Billett, B.; Brajuskovic, B.; Carter, J.; Kirkus, E.; Lale, M.; Lerch, J.; Noonan, J.; O' Neill, M.; Rocke, B.; Suthar, K.; Walters, D.; Wiemerslage, G.; Zientek, J.

2017-06-20

Recent work on the design of the storage ring vacuum system for the Advanced Photon Source Upgrade project (APS-U) includes: revising the vacuum system design to accommodate a new lattice with reverse bend magnets, modifying the designs of vacuum chambers in the FODO sections for more intense incident synchrotron radiation power, modifying the design of rf-shielding bellows liners for better performance and reliability, modifying photon absorber designs to make better use of available space, and integrated planning of components needed in the injection, extraction and rf cavity straight sections. An overview of progress in these areas is presented.

Optimization of electronic enclosure design for thermal and moisture management using calibrated models of progressive complexity

DEFF Research Database (Denmark)

Mohanty, Sankhya; Staliulionis, Zygimantas; Shojaee Nasirabadi, Parizad

2016-01-01

the development of rigorous calibrated CFD models as well as simple predictive numerical tools, the current paper tackles the optimization of critical features of a typical two-chamber electronic enclosure. The progressive optimization strategy begins the design parameter selection by initially using simpler...

Progress on axicell MFTF-B superconducting magnet systems

International Nuclear Information System (INIS)

Wang, S.T.; Kozman, T.A.; Hanson, C.L.; Shimer, D.W.; VanSant, J.H.; Zbasnik, J.

1983-01-01

Since the entire Mirror Fusion Test Facility (MFTF-B) Magnet System was reconfigured from the original A-cell to an axicell design, much progress has been made on the design, fabrication, and installation planning. The axicell MFTF-B magnet array consists of a total of 26 large superconducting main coils. This paper provides an engineering overview of the progress of these coils. Recent studies on the effects of field errors on the plasma at the recircularizing region (transition coils) show that small field errors will generate large displacements of the field lines. These field errors might enhance radial electron heat transport and deteriorate the plasma confinement. Therefore, 16 superconducting trim coils have been designed to correct the coil misalignments. Progress of the trim coils are reported also

Development of an extended-burnup Mark B design. Second semiannual progress report, January-June 1979

International Nuclear Information System (INIS)

1979-11-01

The immediate goal of the DOE/AP and L/B and W project is to extend the burnup of light water reactor fuel assemblies beyond present limits to 50,000 MWd/mtU batch average burnup. Fuel management plans and fuel designs are being directed to attain the increased burnup limits. Lead-test assemblies of extended-burnup designs will be manufactured, irradiated in a commercial pressurized water reactor, and examined to support extended-burnup fuel cycles. This report, covering the period from January through June 1979, is the second semiannual progress report for the program. Efforts have included analyses of extended-burnup fuel cycles, developed of both annular fuel pellet and segmented rod designs, and design of a nondestructive post-irradiation examination system

ITER [International Thermonuclear Experimental Reactor] reactor building design study

International Nuclear Information System (INIS)

Thomson, S.L.; Blevins, J.D.; Delisle, M.W.

1989-01-01

The International Thermonuclear Experimental Reactor (ITER) is at the midpoint of a two-year conceptual design. The ITER reactor building is a reinforced concrete structure that houses the tokamak and associated equipment and systems and forms a barrier between the tokamak and the external environment. It provides radiation shielding and controls the release of radioactive materials to the environment during both routine operations and accidents. The building protects the tokamak from external events, such as earthquakes or aircraft strikes. The reactor building requirements have been developed from the component designs and the preliminary safety analysis. The equipment requirements, tritium confinement, and biological shielding have been studied. The building design in progress requires continuous iteraction with the component and system designs and with the safety analysis. 8 figs

Progress in resolving open design issues from the ODR. Report by the Director. ITER technical advisory committee meeting, 25-27 June 2000, St. Petersburg

International Nuclear Information System (INIS)

2000-01-01

This report presents progress in resolving open design issues from the ITER-FEAT Outline Design Report and is not repeating the ODR information but concentrates on the specific issues and the progress towards their resolution. It includes some aspects of the Physics analysis (inductive operation scenario and sensitivity analysis, ion heating, possibility of high Q and ignition operation, divertor physics), Magnets (TF coil loads, inductive flux generation, conductor design issues), Vessel/in Vessel (manifolding of blanket coolant, vacuum vessel design development, design implications of divertor material choice), Buildings and Plant services, Operation and Safety

Status of Progress Made Toward Preliminary Design Concepts for the Inventory in Select Media for DOE-Managed HLW/SNF

Energy Technology Data Exchange (ETDEWEB)

Matteo, Edward N. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Hardin, Ernest L. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Hadgu, Teklu [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Park, Heeho Daniel [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Rigali, Mark J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Jove-Colon, Carlos F. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

2016-09-30

As the title suggests, this report provides a summary of the status and progress for the Preliminary Design Concepts Work Package. Described herein are design concepts and thermal analysis for crystalline and salt host media. The report concludes that thermal management of defense waste, including the relatively small subset of high thermal output waste packages, is readily achievable. Another important conclusion pertains to engineering feasibility, and design concepts presented herein are based upon established and existing elements and/or designs. The multipack configuration options for the crystalline host media pose the greatest engineering challenges, as these designs involve large, heavy waste packages that pose specific challenges with respect to handling and emplacement. Defense-related Spent Nuclear Fuel (DSNF) presents issues for post-closure criticality control, and a key recommendation made herein relates to the need for special packaging design that includes neutron-absorbing material for the DSNF. Lastly, this report finds that the preliminary design options discussed are tenable for operational and post-closure safety, owing to the fact that these concepts have been derived from other published and well-studied repository designs.

Progressing state of design and R and D of NBI for ITER

Energy Technology Data Exchange (ETDEWEB)

Ohara, Yoshihiro [Japan Atomic Energy Research Inst., Naka, Ibaraki (Japan). Naka Fusion Research Establishment

1997-02-01

In the International Thermal Nuclear Fusion Experimental Reactor (ITER), Neutral Beam Injection (NBI) apparatus is thought to be a powerful means of electric current drive for heating and stabilizing of plasma, and of controlling the plasma stably. Then, design and development of 1 MeV class negative ion NBI apparatus with compactness and better consistency with reactor have been conducted. On its engineering design, numbers of ports for NBI apparatus were changed form 3 to 4 on a stage of intermediate design completion on June, 1995, and then incident power per unit port was increased from 12.5 MW to 16.7 MW, which brought severer characteristics required for negative ion source. At present, designs of beam deflector, magnetic shield, neutron shielding, remote maintenance and so forth as well as negative ion source and accelerator have been progressed. On its engineering R and D, for development of negative ion source, both deuterium negative ion current and its density established about 1/3 of the characteristics in ITER actural apparatus at an aimed operational gas pressure. And, for development of negative ion accerelator, over 80% of the negative ion acceleration energy which corresponds to an aim of ITER could be established. (G.K.)

Design Research on Mathematics Education: Investigating The Progress of Indonesian Fifth Grade Students’ Learning on Multiplication of Fractions With Natural Numbers

Directory of Open Access Journals (Sweden)

Nenden Octavarulia Shanty

2011-07-01

Full Text Available This study aimed at investigating the progress of students’ learning onmultiplication fractions with natural numbers through the five activitylevels based on Realistic Mathematics Education (RME approachproposed by Streefland. Design research was chosen to achieve thisresearch goal. In design research, the Hypothetical Learning Trajectory(HLT plays important role as a design and research instrument. ThisHLT tested to thirty-seven students of grade five primary school (i.e.SDN 179 Palembang.The result of the classroom practices showed that measurement (lengthactivity could stimulate students’ to produce fractions as the first levelin learning multiplication of fractions with natural numbers.Furthermore, strategies and tools used by the students in partitioninggradually be developed into a more formal mathematics in whichnumber line be used as the model of measuring situation and the modelfor more formal reasoning. The number line then could bring thestudents to the last activity level, namely on the way to rules formultiplying fractions with natural numbers. Based on this findings, it is suggested that Streefland’s five activity levels can be used as aguideline in learning multiplication of fractions with natural numbers in which the learning process become a more progressive learning.

Parametric study of variation in cargo-airplane performance related to progression from current to spanloader designs

Science.gov (United States)

Toll, T. A.

1980-01-01

A parametric analysis was made to investigate the relationship between current cargo airplanes and possible future designs that may differ greatly in both size and configuration. The method makes use of empirical scaling laws developed from statistical studies of data from current and advanced airplanes and, in addition, accounts for payload density, effects of span distributed load, and variations in tail area ratio. The method is believed to be particularly useful for exploratory studies of design and technology options for large airplanes. The analysis predicts somewhat more favorable variations of the ratios of payload to gross weight and block fuel to payload as the airplane size is increased than has been generally understood from interpretations of the cube-square law. In terms of these same ratios, large all wing (spanloader) designs show an advantage over wing-fuselage designs.

Chemical engineering in the electronics industry: progress towards the rational design of organic semiconductor heterojunctions

KAUST Repository

Clancy, Paulette

2012-05-01

We review the current status of heterojunction design for combinations of organic semiconductor materials, given its central role in affecting the device performance for electronic devices and solar cell applications. We provide an emphasis on recent progress towards the rational design of heterojunctions that may lead to higher performance of charge separation and mobility. We also play particular attention to the role played by computational approaches and its potential to help define the best choice of materials for solar cell development in the future. We report the current status of the field with respect to such goals. © 2012 Elsevier Ltd.

Chemical engineering in the electronics industry: progress towards the rational design of organic semiconductor heterojunctions

KAUST Repository

Clancy, Paulette

2012-01-01

We review the current status of heterojunction design for combinations of organic semiconductor materials, given its central role in affecting the device performance for electronic devices and solar cell applications. We provide an emphasis on recent progress towards the rational design of heterojunctions that may lead to higher performance of charge separation and mobility. We also play particular attention to the role played by computational approaches and its potential to help define the best choice of materials for solar cell development in the future. We report the current status of the field with respect to such goals. © 2012 Elsevier Ltd.

Progress in study of a medical reactor for boron neutron capture therapy

International Nuclear Information System (INIS)

Sasaki, Makoto; Hirota, Jitsuya; Tamao, Shigeo; Kanda, Keiji; Mishima, Yutaka.

1993-01-01

A design study of a medical reactor for Boron Neutron Capture Therapy has made progress. Main specifications of the reactor are as follows; thermal power of 2 MW, water cooling by natural convection, semitight core of hexagonal lattice, UO 2 fuel rod of 9.5 mm diameter and no refueling in the reactor-life. Three horizontal and one vertical neutron beam holes are to be provided for simultaneous treatments by thermal and epithermal neutrons and for further biomedical research. The design objectives for the beam holes are to deliver the therapeutic doses in a modest time (30 to 60 min) with minimal fast neutron and gamma contaminants. The n-γ coupling Sn transport calculations have been carried out using n-21 and γ-9 group cross sections on 2-dim. practical models. The calculated results indicate that the design objectives will be achievable even if the thermal power of the reactor is reduced to 1 MW. (author)

Fusion-reactor physics and technology studies. Progress report, December 1, 1982-June 30, 1983

International Nuclear Information System (INIS)

Kulcinski, G.L.; Emmert, G.A.; Maynard, C.W.

1983-01-01

The work performed during the past fiscal year (1983) was directed almost entirely towards the MARS project. This tandem mirror reactor design study is due to be finished in September of 1983 and a final report will be issued at that time. The present report mainly covers progress made after the interim report and is meant to supplement information in UCRL-53333. The areas covered in this present report are: (1) blanket design improvements; (2) end cell neutronics; (3) RF heating systems; (4) economic optimization of blanket; (5) plasma startup; (6) Li 17 Pb 83 corrosion; (7) double walled steam generator analysis; and (8) tritium system

Design progress of HYPER system

International Nuclear Information System (INIS)

Park, Won S.; Hwang, Woan; Kim, Yong H.; Nam-Il Tak; Song, Tae Y.

2001-01-01

Korea Atomic Energy Research Institute (KAERI) has been performing accelerator driven system related research and development called HYPER for the transmutation of nuclear waste and energy production through the transmutation process. HYPER program is within the framework of the national mid and long-term nuclear research plan. KAERI is aiming to develop the system concept and a type of roadmap by the year of 2001 and complete the conceptual design of HYPER system by the year 2006. Some major design features of HYPER system have been developed. Burnable poison concept is being developed to keep the core reactivity swing less than 10%. In order to increase the proliferation resistance, a pyrochemical process is employed for the separation. The trade-off studies for the fuel fabrication are being performed. A dispersion type is believed to have advantages in terms of achieving high discharge burnup. The long-lived fission products such as Tc-99 and I-129 will be destroyed using the localized thermal neutrons separately in the HYPER. A calcium hydride is employed as moderator. SSC-H(Super System Code-HYPER) is being developed to simulate the behavior of coolant systems. The thermal hydraulic properties of Pb-Bi are implemented to SSC-H. The design optimization of target and beam window is performed using FLUENT and ANSYS computer codes. In addition, beam irradiation test is performed to estimate the hardness of window material (9Cr-2WVTa) due to the proton using KeV order accelerator. Beam diameter and window thickness are optimized based on the simulation results. (author)

HT-7U superconducting tokamak: Physics design, engineering progress and schedule

International Nuclear Information System (INIS)

Wan Yuanxi

2002-01-01

The superconducting tokamak research program begun in China in ASIPP since 1994. The program is included in existent superconducting tokamak HT-7 and the next new superconducting tokamak HT-7U which is one of national key research projects in China. With the elongation cross-section, divertor and higher plasma parameter the main objectives of HT-7U are widely investigation both of the physics and technology for steady state advanced tokamak as well as the investigation of power and particle handle under steady-state operation condition. The physics and engineering design have been completed and significant progresses on R and D and fabrication have been achieved. HT-7U will begin assembly at 2003 and possible to get first plasma around 2004. (author)

Progress in the design of Normal Heat Flux First Wall panels for ITER

Energy Technology Data Exchange (ETDEWEB)

Cicero, Tindaro, E-mail: Tindaro.Cicero@f4e.europa.eu [Fusion for Energy, Josep Pla 2, Torres Diagonal Litoral B3, 08019 Barcelona (Spain); Jimenez, Marc; D’Amico, Gabriele; Pou, Jordi Ayneto; Dellopoulos, Georges; Alvaro, Elena; Cardenes, Sabas; Banetta, Stefano; Bellin, Boris; Zacchia, Francesco [Fusion for Energy, Josep Pla 2, Torres Diagonal Litoral B3, 08019 Barcelona (Spain); Calcagno, Barbara; Chappuis, Philippe; Gicquel, Stefan; Mitteau, Raphael; Raffray, Rene [ITER Organization, Route de Vinon-sur-Verdon, CS 90 046, 13067 St., Paul Lez Durance Cedex (France)

2015-10-15

Highlights: • Improved detail design of several NHF FW panels for ITER. • Implemented design solutions to improve the manufacturing of NHF FW panels. • Performed FEM simulations for the overall assessment of NHF FW panels. • Performed detailed analyses for integration of diagnostics in the NHF FW panels. - Abstract: A typical NHF FW panel consists of a series of fingers, which represent the elementary plasma facing units and are designed to withstand 15,000 cycles at 2 MW/m{sup 2}. The fingers are mechanically joined and supported by a back structural element or “supporting beam”. The structure of a finger is made of three different materials: stainless steel for the supporting structure, copper chromium zirconium for the heat sink, and beryllium as armour material. Due to their location and to the interfaces with other systems (e.g. Diagnostics, Remote Handling), the NHF FW panels are divided in different main and minor variants. The aim of this paper is to present the design work performed towards the PA signature. CAD detailed models have been created in CATIA for main and minor variants. Examples of local design solutions, as well as design work to achieve the global configuration of specific modules are provided. Finite Element (FE) analyses have been carried out, in order to simulate the operational scenario of ITER and assess the thermo-mechanical behaviour of the most important FW panels against the required design criteria. This design and analyses activity is required to progress towards the finalization of the detailed design of the NHF FW main and minor variants.

Progress in the design of Normal Heat Flux First Wall panels for ITER

International Nuclear Information System (INIS)

Cicero, Tindaro; Jimenez, Marc; D’Amico, Gabriele; Pou, Jordi Ayneto; Dellopoulos, Georges; Alvaro, Elena; Cardenes, Sabas; Banetta, Stefano; Bellin, Boris; Zacchia, Francesco; Calcagno, Barbara; Chappuis, Philippe; Gicquel, Stefan; Mitteau, Raphael; Raffray, Rene

2015-01-01

Highlights: • Improved detail design of several NHF FW panels for ITER. • Implemented design solutions to improve the manufacturing of NHF FW panels. • Performed FEM simulations for the overall assessment of NHF FW panels. • Performed detailed analyses for integration of diagnostics in the NHF FW panels. - Abstract: A typical NHF FW panel consists of a series of fingers, which represent the elementary plasma facing units and are designed to withstand 15,000 cycles at 2 MW/m"2. The fingers are mechanically joined and supported by a back structural element or “supporting beam”. The structure of a finger is made of three different materials: stainless steel for the supporting structure, copper chromium zirconium for the heat sink, and beryllium as armour material. Due to their location and to the interfaces with other systems (e.g. Diagnostics, Remote Handling), the NHF FW panels are divided in different main and minor variants. The aim of this paper is to present the design work performed towards the PA signature. CAD detailed models have been created in CATIA for main and minor variants. Examples of local design solutions, as well as design work to achieve the global configuration of specific modules are provided. Finite Element (FE) analyses have been carried out, in order to simulate the operational scenario of ITER and assess the thermo-mechanical behaviour of the most important FW panels against the required design criteria. This design and analyses activity is required to progress towards the finalization of the detailed design of the NHF FW main and minor variants.

SuperB Progress Report: Detector

Energy Technology Data Exchange (ETDEWEB)

Grauges, E.; /Barcelona U., ECM; Donvito, G.; Spinoso, V.; /INFN, Bari /Bari U.; Manghisoni, M.; Re, V.; Traversi, G.; /INFN, Pavia /Bergamo U., Ingengneria Dept.; Eigen, G.; Fehlker, D.; Helleve, L.; /Bergen U.; Carbone, A.; Di Sipio, R.; Gabrielli, A.; Galli, D.; Giorgi, F.; Marconi, U.; Perazzini, S.; Sbarra, C.; Vagnoni, V.; Valentinetti, S.; Villa, M.; Zoccoli, A.; /INFN, Bologna /Bologna U. /Caltech /Carleton U. /Cincinnati U. /INFN, CNAF /INFN, Ferrara /Ferrara U. /UC, Irvine /Taras Shevchenko U. /Orsay, LAL /LBL, Berkeley /UC, Berkeley /Frascati /INFN, Legnaro /Orsay, IPN /Maryland U. /McGill U. /INFN, Milan /Milan U. /INFN, Naples /Naples U. /Novosibirsk, IYF /INFN, Padua /Padua U. /INFN, Pavia /Pavia U. /INFN, Perugia /Perugia U. /INFN, Perugia /Caltech /INFN, Pisa /Pisa U. /Pisa, Scuola Normale Superiore /PNL, Richland /Queen Mary, U. of London /Rutherford /INFN, Rome /Rome U. /INFN, Rome2 /Rome U.,Tor Vergata /INFN, Rome3 /Rome III U. /SLAC /Tel Aviv U. /INFN, Turin /Turin U. /INFN, Padua /Trento U. /INFN, Trieste /Trieste U. /TRIUMF /British Columbia U. /Montreal U. /Victoria U.

2012-02-14

This report describes the present status of the detector design for SuperB. It is one of four separate progress reports that, taken collectively, describe progress made on the SuperB Project since the publication of the SuperB Conceptual Design Report in 2007 and the Proceedings of SuperB Workshop VI in Valencia in 2008.

SuperB Progress Report: Detector

International Nuclear Information System (INIS)

Grauges, E.; Donvito, G.; Spinoso, V.; Manghisoni, M.; Re, V.; Traversi, G.; Eigen, G.; Fehlker, D.; Helleve, L.; Cheng, C.; Chivukula, A.; Doll, D.; Echenard, B.; Hitlin, D.; Ongmongkolkul, P.; Porter, F.; Rakitin, A.; Thomas, M.; Zhu, R.; Tatishvili, G.; Andreassen, R.; Fabby, C.; Meadows, B.; Simpson, A.; Sokoloff, M.; Tomko, K.; Fella, A.; Andreotti, M.; Baldini, W.; Calabrese, R.; Carassiti, V.; Cibinetto, G.; Cotta Ramusino, A.; Gianoli, A.; Luppi, E.; Munerato, M.; Santoro, V.; Tomassetti, L.; Stoker, D.; Bezshyyko, O.; Dolinska, G.; Arnaud, N.; Beigbeder, C.; Bogard, F.; Breton, D.; Burmistrov, L.; Charlet, D.; Maalmi, J.; Perez Perez, L.; Puill, V.; Stocchi, A.; Tocut, V.; Wallon, S.; Wormser, G.; Brown, D.

2012-01-01

This report describes the present status of the detector design for SuperB. It is one of four separate progress reports that, taken collectively, describe progress made on the SuperB Project since the publication of the SuperB Conceptual Design Report in 2007 and the Proceedings of SuperB Workshop VI in Valencia in 2008.

SuperB Progress Reports Accelerator

CERN Document Server

Biagini, Maria Enrica; Boscolo, M; Buonomo, B; Demma, T; Drago, A; Esposito, M; Guiducci, S; Mazzitelli, G; Pellegrino, L; Preger, M A; Raimondi, P; Ricci, R; Rotundo, U; Sanelli, C; Serio, M; Stella, A; Tomassini, S; Zobov, M; Bertsche, K; Brachman, A; Cai, Y; Chao, A; Chesnut, R; Donald, M.H; Field, C; Fisher, A; Kharakh, D; Krasnykh, A; Moffeit, K; Nosochkov, Y; Pivi, M; Seeman, J; Sullivan, M.K; Weathersby, S; Weidemann, A; Weisend, J; Wienands, U; Wittmer, W; Woods, M; Yocky, G; Bogomiagkov, A; Koop, I; Levichev, E; Nikitin, S; Okunev, I; Piminov, P; Sinyatkin, S; Shatilov, D; Vobly, P; Bosi, F; Liuzzo, S; Paoloni, E; Bonis, J; Chehab, R; Le Meur, G; Lepercq, P; Letellier-Cohen, F; Mercier, B; Poirier, F; Prevost, C; Rimbault, C; Touze, F; Variola, A; Bolzon, B; Brunetti, L; Jeremie, A; Baylac, M; Bourrion, O; De Conto, J M; Gomez, Y; Meot, F; Monseu, N; Tourres, D; Vescovi, C; Chanci, A; Napoly, O; Barber, D P; Bettoni, S; Quatraro, D

2010-01-01

This report details the present status of the Accelerator design for the SuperB Project. It is one of four separate progress reports that, taken collectively, describe progress made on the SuperB Project since the publication of the SuperB Conceptual Design Report in 2007 and the Proceedings of SuperB Workshop VI in Valencia in 2008.

Association between circulating vitamin K1 and coronary calcium progression in community-dwelling adults: the Multi-Ethnic Study of Atherosclerosis

Science.gov (United States)

While animal studies found vitamin K treatment reduced vascular calcification, human data are limited. Using a case-cohort design, we determined the association between vitamin K status and coronary artery calcium (CAC) progression in the Multi-ethnic Study of Atherosclerosis. Serum phylloquinone (v...

Studies of human mutation rates: Progress report

International Nuclear Information System (INIS)

Neel, J.V.

1988-01-01

Progress was recorded between January 1 and July 1, 1987 on a project entitled ''Studies of Human Mutation Rates''. Studies underway include methodology for studying mutation at the DNA level, algorithms for automated analyses of two-dimensional polyacrylamide DNA gels, theoretical and applied population genetics, and studies of mutation frequency in A-bomb survivors

Progress in the ITER electron cyclotron heating and current drive system design

Energy Technology Data Exchange (ETDEWEB)

Omori, Toshimichi, E-mail: toshimichi.omori@iter.org [ITER Organization, Route de Vinon sur Verdon, CS 90 046, 13067 St Paul Lez Durance Cedex (France); Albajar, Ferran; Bonicelli, Tullio; Carannante, Giuseppe; Cavinato, Mario; Cismondi, Fabio [Fusion for Energy, Josep Pla 2, Barcelona 08019 (Spain); Darbos, Caroline [ITER Organization, Route de Vinon sur Verdon, CS 90 046, 13067 St Paul Lez Durance Cedex (France); Denisov, Grigory [Institute of Applied Physics Russian Academy of Sciences, 46 Ulyanov Street, Nizhny Novgorod 603950 (Russian Federation); Farina, Daniela [Istituto di Fisica del Plasma, Association EURATOM-ENEA-CNR, Milano (Italy); Gagliardi, Mario [Fusion for Energy, Josep Pla 2, Barcelona 08019 (Spain); Gandini, Franco; Gassmann, Thibault [ITER Organization, Route de Vinon sur Verdon, CS 90 046, 13067 St Paul Lez Durance Cedex (France); Goodman, Timothy [CRPP, Association EURATOM-Confédération Suisse, EPFL Ecublens, CH-1015 Lausanne (Switzerland); Hanson, Gregory [US ITER Project Office, ORNL, 055 Commerce Park, PO Box 2008, Oak Ridge, TN 37831 (United States); Henderson, Mark A. [ITER Organization, Route de Vinon sur Verdon, CS 90 046, 13067 St Paul Lez Durance Cedex (France); Kajiwara, Ken [Japan Atomic Energy Agency (JAEA), 801-1 Mukoyama, Naka-shi, Ibaraki 311-0193 (Japan); McElhaney, Karen [US ITER Project Office, ORNL, 055 Commerce Park, PO Box 2008, Oak Ridge, TN 37831 (United States); Nousiainen, Risto [Fusion for Energy, Josep Pla 2, Barcelona 08019 (Spain); Oda, Yasuhisa [Japan Atomic Energy Agency (JAEA), 801-1 Mukoyama, Naka-shi, Ibaraki 311-0193 (Japan); Oustinov, Alexander [Institute of Applied Physics Russian Academy of Sciences, 46 Ulyanov Street, Nizhny Novgorod 603950 (Russian Federation); and others

2015-10-15

Highlights: • EC system is designed with an ability to upgrade in power to 28 MW then 40 MW. • The TL is capable of 3 buildings movements; ±15 mm displacements at the worst. • Improved power deposition access injecting 20 MW across nearly the entire plasma. • Ensured nuclear safety by appropriate definition of confinement boundaries. • Proposed I&C architecture for the overall EC plant was successfully reviewed. - Abstract: An electron cyclotron system is one of the four auxiliary plasma heating systems to be installed on the ITER tokamak. The ITER EC system consists of 24 gyrotrons with associated 12 high voltage power supplies, a set of evacuated transmission lines and two types of launchers. The whole system is designed to inject 20 MW of microwave power at 170 GHz into the plasma. The primary functions of the system include plasma start-up, central heating and current drive, and magneto-hydrodynamic instabilities control. The design takes present day technology and extends towards high power CW operation, which represents a large step forward as compared to the present state of the art. The ITER EC system will be a stepping stone to future EC systems for DEMO and beyond. The EC system is faced with significant challenges, which not only includes an advanced microwave system for plasma heating and current drive applications but also has to comply with stringent requirements associated with nuclear safety as ITER became the first fusion device licensed as basic nuclear installations as of 9 November 2012. Since conceptual design of the EC system established in 2007, the EC system has progressed to a preliminary design stage in 2012, and is now moving forward towards a final design. The majority of the subsystems have completed the detailed design and now advancing towards the final design completion.

Progress in the ITER electron cyclotron heating and current drive system design

International Nuclear Information System (INIS)

Omori, Toshimichi; Albajar, Ferran; Bonicelli, Tullio; Carannante, Giuseppe; Cavinato, Mario; Cismondi, Fabio; Darbos, Caroline; Denisov, Grigory; Farina, Daniela; Gagliardi, Mario; Gandini, Franco; Gassmann, Thibault; Goodman, Timothy; Hanson, Gregory; Henderson, Mark A.; Kajiwara, Ken; McElhaney, Karen; Nousiainen, Risto; Oda, Yasuhisa; Oustinov, Alexander

2015-01-01

Highlights: • EC system is designed with an ability to upgrade in power to 28 MW then 40 MW. • The TL is capable of 3 buildings movements; ±15 mm displacements at the worst. • Improved power deposition access injecting 20 MW across nearly the entire plasma. • Ensured nuclear safety by appropriate definition of confinement boundaries. • Proposed I&C architecture for the overall EC plant was successfully reviewed. - Abstract: An electron cyclotron system is one of the four auxiliary plasma heating systems to be installed on the ITER tokamak. The ITER EC system consists of 24 gyrotrons with associated 12 high voltage power supplies, a set of evacuated transmission lines and two types of launchers. The whole system is designed to inject 20 MW of microwave power at 170 GHz into the plasma. The primary functions of the system include plasma start-up, central heating and current drive, and magneto-hydrodynamic instabilities control. The design takes present day technology and extends towards high power CW operation, which represents a large step forward as compared to the present state of the art. The ITER EC system will be a stepping stone to future EC systems for DEMO and beyond. The EC system is faced with significant challenges, which not only includes an advanced microwave system for plasma heating and current drive applications but also has to comply with stringent requirements associated with nuclear safety as ITER became the first fusion device licensed as basic nuclear installations as of 9 November 2012. Since conceptual design of the EC system established in 2007, the EC system has progressed to a preliminary design stage in 2012, and is now moving forward towards a final design. The majority of the subsystems have completed the detailed design and now advancing towards the final design completion.

Progress in octahedral spherical hohlraum study

Directory of Open Access Journals (Sweden)

Ke Lan

2016-01-01

Full Text Available In this paper, we give a review of our theoretical and experimental progress in octahedral spherical hohlraum study. From our theoretical study, the octahedral spherical hohlraums with 6 Laser Entrance Holes (LEHs of octahedral symmetry have robust high symmetry during the capsule implosion at hohlraum-to-capsule radius ratio larger than 3.7. In addition, the octahedral spherical hohlraums also have potential superiority on low backscattering without supplementary technology. We studied the laser arrangement and constraints of the octahedral spherical hohlraums, and gave a design on the laser arrangement for ignition octahedral hohlraums. As a result, the injection angle of laser beams of 50°–60° was proposed as the optimum candidate range for the octahedral spherical hohlraums. We proposed a novel octahedral spherical hohlraum with cylindrical LEHs and LEH shields, in order to increase the laser coupling efficiency and improve the capsule symmetry and to mitigate the influence of the wall blowoff on laser transport. We studied on the sensitivity of the octahedral spherical hohlraums to random errors and compared the sensitivity among the octahedral spherical hohlraums, the rugby hohlraums and the cylindrical hohlraums, and the results show that the octahedral spherical hohlraums are robust to these random errors while the cylindrical hohlraums are the most sensitive. Up till to now, we have carried out three experiments on the spherical hohlraum with 2 LEHs on Shenguang(SG laser facilities, including demonstration of improving laser transport by using the cylindrical LEHs in the spherical hohlraums, spherical hohlraum energetics on the SGIII prototype laser facility, and comparisons of laser plasma instabilities between the spherical hohlraums and the cylindrical hohlraums on the SGIII laser facility.

Maryland University sectored isochronous cyclotron (MUSIC): Progress report No. 8

Energy Technology Data Exchange (ETDEWEB)

1966-07-10

Progress is reported in the area of acquiring a magnet frame, coils, and magnet handling equipment. Progress is also reported in relation to the design of the rf system. A detailed account is given of magnet system measurements and rf system studies, as well as studies of the amplifier chain. (LEW)

High temperature turbine technology program. Phase II. Technology test and support studies. Annual technical progress report, January 1, 1979-December 31, 1979

Energy Technology Data Exchange (ETDEWEB)

1980-01-01

Work performed on the High Temperature Turbine Technology Program, Phase II - Technology Test and Support Studies during the period from January 1, 1979 through December 31, 1979 is summarized. Objectives of the program elements as well as technical progress and problems encountered during this Phase II annual reporting period are presented. Progress on design, fabrication and checkout of test facilities and test rigs is described. LP turbine cascade tests were concluded. 350 hours of testing were conducted on the LP rig engine first with clean distillate fuel and then with fly ash particulates injected into the hot gas stream. Design and fabrication of the turbine spool technology rig components are described. TSTR 60/sup 0/ sector combustor rig fabrication and testing are reviewed. Progress in the design and fabrication of TSTR cascade rig components for operation on both distillate fuel and low Btu gas is described. The new coal-derived gaseous fuel synthesizing facility is reviewed. Results and future plans for the supporting metallurgical programs are discussed.

Electron-beam-fusion progress report, January--June 1976

International Nuclear Information System (INIS)

1976-10-01

Research progress is reported for the following areas: (1) Proto I, (2) Proto II, (3) EBFA, (4) power flow, (5) contract progress reports, (6) progress in the Sandia program, (7) repetitively operated pulse generator development, (8) electron beam power from inductive storage, (9) fusion target design, (10) beam physics research, (11) power flow, (12) heavy ion fusion, (13) particle beam source development, (14) beam target interaction and target response studies, (15) diagnostic development, and (16) hybrid systems

Progress in welding studies for Canadian nuclear fuel waste disposal containers

International Nuclear Information System (INIS)

Maak, P.Y.Y.

1985-11-01

This report describes the progress in the development of closure-welding technology for Canadian nuclear fuel waste disposal containers. Titanium, copper and Inconel 625 are being investigated as candidate materials for fabrication of these containers. Gas-tungsten-arc welding, gas metal-arc-welding, resistance-heated diffusion bonding and electron beam welding have been evaluated as candidate closure welding processes. Characteristic weldment properties, relative merits of welding techniques, suitable weld joint configurations and fit-up tolerances, and welding parameter control ranges have been identified for various container designs. Furthermore, the automation requirements for candidate welding processes have been assessed. Progress in the development of a computer-controlled remote gas-shielded arc welding system is described

Using CFD as a Rocket Injector Design Tool: Recent Progress at Marshall Space Flight Center

Science.gov (United States)

Tucker, Kevin; West, Jeff; Williams, Robert; Lin, Jeff; Canabal, Francisco; Rocker, marvin; Robles, Bryan; Garcia, Robert; Chenoweth, James

2005-01-01

some detail. The objectives of each effort were noted. Issues relative to code validation for injector design were discussed in some detail. The requirement for CFD support during the design of the experiment was noted and discussed in terms of instrumentation placement and experimental rig uncertainty. In conclusion, MSFC has made significant progress in the last two years in advancing CFD toward the goal of application to injector design. A parallel effort focused on program support and technology development via the SCIT Task have enabled the progress.

Design for energy efficiency: Energy efficient industrialized housing research program. Progress report

Energy Technology Data Exchange (ETDEWEB)

Kellett, R.; Berg, R.; Paz, A.; Brown, G.Z.

1991-03-01

Since 1989, the U.S. Department of Energy has sponsored the Energy Efficient Industrialized Housing research program (EEIH) to improve the energy efficiency of industrialized housing. Two research centers share responsibility for this program: The Center for Housing Innovation at the University of Oregon and the Florida Solar Energy Center, a research institute of the University of Central Florida. Additional funding is provided through the participation of private industry, state governments and utilities. The program is guided by a steering committee comprised of industry and government representatives. This report summarizes Fiscal Year (FY) 1990 activities and progress, and proposed activities for FY 1991 in Task 2.1 Design for Energy Efficiency. This task establishes a vision of energy conservation opportunities in critical regions, market segments, climate zones and manufacturing strategies significant to industrialized housing in the 21st Century. In early FY 1990, four problem statements were developed to define future housing demand scenarios inclusive of issues of energy efficiency, housing design and manufacturing. Literature surveys were completed to assess seven areas of influence for industrialized housing and energy conservation in the future. Fifty-five future trends were identified in computing and design process; manufacturing process; construction materials, components and systems; energy and environment; demographic context; economic context; and planning policy and regulatory context.

In silico design and biological evaluation of a dual specificity kinase inhibitor targeting cell cycle progression and angiogenesis.

Science.gov (United States)

Latham, Antony M; Kankanala, Jayakanth; Fearnley, Gareth W; Gage, Matthew C; Kearney, Mark T; Homer-Vanniasinkam, Shervanthi; Wheatcroft, Stephen B; Fishwick, Colin W G; Ponnambalam, Sreenivasan

2014-01-01

Protein kinases play a central role in tumor progression, regulating fundamental processes such as angiogenesis, proliferation and metastasis. Such enzymes are an increasingly important class of drug target with small molecule kinase inhibitors being a major focus in drug development. However, balancing drug specificity and efficacy is problematic with off-target effects and toxicity issues. We have utilized a rational in silico-based approach to demonstrate the design and study of a novel compound that acts as a dual inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2) and cyclin-dependent kinase 1 (CDK1). This compound acts by simultaneously inhibiting pro-angiogenic signal transduction and cell cycle progression in primary endothelial cells. JK-31 displays potent in vitro activity against recombinant VEGFR2 and CDK1/cyclin B proteins comparable to previously characterized inhibitors. Dual inhibition of the vascular endothelial growth factor A (VEGF-A)-mediated signaling response and CDK1-mediated mitotic entry elicits anti-angiogenic activity both in an endothelial-fibroblast co-culture model and a murine ex vivo model of angiogenesis. We deduce that JK-31 reduces the growth of both human endothelial cells and human breast cancer cells in vitro. This novel synthetic molecule has broad implications for development of similar multi-kinase inhibitors with anti-angiogenic and anti-cancer properties. In silico design is an attractive and innovative method to aid such drug discovery.

Search for design intelligence: A field study on the role of emotional intelligence in architectural design studios

Directory of Open Access Journals (Sweden)

Sajjad Nazidizaji

2014-12-01

Full Text Available The design studio is the core of the architecture curriculum. Interpersonal interactions have a key role during the processes of design and critique. The influence of emotional intelligence (EQ on interpersonal communication skills has been widely proven. This study examines the correlation between EQ and architectural design competence. To achieve this, 78 architecture students were selected via a simple random sampling method and tested using an EQ test questionnaire developed by Bradbury and Greaves (2006. The scores of five architectural design studio courses (ADS-1, ADS-2, ADS-3, ADS-4, and ADS-5 were used as indicators of the progress in design of the students. Descriptive and inferential statistics methods were both employed to analyze the research data. The methods included correlation analysis, mean comparison t-test for independent samples, and single sample t-test. Findings showed no significant relationship between EQ and any of the indicators.

Progress on the Design of a Perpendicularly Biased 2nd Harmonic Cavity for the Fermilab Booster

Energy Technology Data Exchange (ETDEWEB)

Madrak, R. L. [Fermilab; Dey, J. E. [Fermilab; Duel, K. L. [Fermilab; Kuharik, J. C. [Fermilab; Pellico, W. A. [Fermilab; Reid, J. S. [Fermilab; Romanov, G. [Fermilab; Slabough, M. [Fermilab; Sun, D. [Fermilab; Tan, C. Y. [Fermilab; Terechkine, I. [Fermilab

2016-10-01

perpendicularly biased 2nd harmonic cavity is being designed and built for the Fermilab Booster. Its purpose is to flatten the bucket at injection and thus change the longitudinal beam distribution to decrease space charge effects. It can also help at extraction. The cavity frequency range is 76 – 106 MHz. The power amplifier will be built using the Y567B tetrode, which is also used for the fundamental mode cavities in the Fermilab Booster. We discuss recent progress on the cavity, the biasing solenoid design and plans for testing the tuner's garnet material

Optimal filter design with progressive genetic algorithm for local damage detection in rolling bearings

Science.gov (United States)

Wodecki, Jacek; Michalak, Anna; Zimroz, Radoslaw

2018-03-01

Harsh industrial conditions present in underground mining cause a lot of difficulties for local damage detection in heavy-duty machinery. For vibration signals one of the most intuitive approaches of obtaining signal with expected properties, such as clearly visible informative features, is prefiltration with appropriately prepared filter. Design of such filter is very broad field of research on its own. In this paper authors propose a novel approach to dedicated optimal filter design using progressive genetic algorithm. Presented method is fully data-driven and requires no prior knowledge of the signal. It has been tested against a set of real and simulated data. Effectiveness of operation has been proven for both healthy and damaged case. Termination criterion for evolution process was developed, and diagnostic decision making feature has been proposed for final result determinance.

A Year of Progress: NASA's Space Launch System Approaches Critical Design Review

Science.gov (United States)

Askins, Bruce; Robinson, Kimberly

2015-01-01

NASA's Space Launch System (SLS) made significant progress on the manufacturing floor and on the test stand in 2014 and positioned itself for a successful Critical Design Review in mid-2015. SLS, the world's only exploration-class heavy lift rocket, has the capability to dramatically increase the mass and volume of human and robotic exploration. Additionally, it will decrease overall mission risk, increase safety, and simplify ground and mission operations - all significant considerations for crewed missions and unique high-value national payloads. Development now is focused on configuration with 70 metric tons (t) of payload to low Earth orbit (LEO), more than double the payload of the retired Space Shuttle program or current operational vehicles. This "Block 1" design will launch NASA's Orion Multi-Purpose Crew Vehicle (MPCV) on an uncrewed flight beyond the Moon and back and the first crewed flight around the Moon. The current design has a direct evolutionary path to a vehicle with a 130t lift capability that offers even more flexibility to reduce planetary trip times, simplify payload design cycles, and provide new capabilities such as planetary sample returns. Every major element of SLS has successfully completed its Critical Design Review and now has hardware in production or testing. In fact, the SLS MPCV-to-Stage-Adapter (MSA) flew successfully on the Exploration Flight Test (EFT) 1 launch of a Delta IV and Orion spacecraft in December 2014. The SLS Program is currently working toward vehicle Critical Design Review in mid-2015. This paper will discuss these and other technical and programmatic successes and challenges over the past year and provide a preview of work ahead before the first flight of this new capability.

[Concern points and considerations for pharmacodynamic study design of new traditional Chinese medicines].

Science.gov (United States)

Huang, Fang-Hua

2014-03-01

Pharmacodynamic (PD) studies play an important role in research and development of new traditonal Chinese medicines (TCMs). Phamacologic and toxicologic studies that aim to research drug ability can provide supporting data for the clinical trials and reduce the risk of clinical trials. In recent years, PD studies in TCMs are developing and progressing, but there are still some problems affecting the value of PD studies in the development of new TCMs. The value of PD studies depends on scientific and rational study design. This article summaries some defects in PD study design of new TCMs that are common in the application data, including defects in study type, testing targets, dosing, duration of administration, control group, testing time. This article also discusses some points of concern and specific requirements for PD study design of new TCMs.

Recent progress in ecological studies of soil fauna

NARCIS (Netherlands)

Hasegawa, Motohiro; Fujii, Saori; Kaneda, Satoshi; Ikeda, Hiroshi; Hishi, Takuo; Hyodo, Fujio; Kobayashi, Makoto

2017-01-01

Progress in ecological studies of soil fauna includes studies of the role and effects of soil fauna on decomposition and soil carbon dynamics in relation to global environmental changes, the introduction of molecular biology approaches to such studies, feeding habit analysis using stable isotopes,

Feeling bad about progress does not lead people want to change their health behaviour.

Science.gov (United States)

Reynolds, James P; Webb, Thomas L; Benn, Yael; Chang, Betty P I; Sheeran, Paschal

2018-02-01

When do people decide to do something about problematic health behaviours? Theoretical models and pragmatic considerations suggest that people should take action when they feel bad about their progress - in other words, when they experience negative progress-related affect. However, the impact of progress-related affect on goal striving has rarely been investigated. Study 1 (N = 744) adopted a cross-sectional design and examined the extent to which measures of progress-related affect were correlated with intentions to take action. Study 2 (N = 409) investigated the impact of manipulating progress-related affect on intentions and behaviour in an experimental design. Study 1 found that, while engaging in health behaviours had the expected affective consequences (e.g. people felt bad when they were not eating healthily, exercising regularly or limiting their alcohol consumption), it was feeling good rather than bad about progress that was associated with stronger intentions. Study 2 replicated these findings. Participants induced to feel good about their eating behaviour had marginally stronger intentions to eat healthily than participants led to feel bad about their eating behaviour. The findings have implications for interventions designed to promote changes in health behaviour, as well as theoretical frameworks for understanding self-regulation.

Study design and baseline findings from the progression of ocular findings (PROOF) natural history study of dry eye.

Science.gov (United States)

McDonnell, Peter J; Pflugfelder, Stephen C; Stern, Michael E; Hardten, David R; Conway, Taryn; Villanueva, Linda; Hollander, David A

2017-12-28

The aim of this research is to initiate a 5-year natural history study of dry eye disease (DED) using objectively assessed and patient-reported outcomes, to explore the hypothesis that DED is a progressive condition that has substantive and measurable impacts not only on the ocular surface, but on quality of life and visual functioning. Our objective for this report is to examine the baseline data. A multicenter, prospective, controlled, observational study of Level 2 (mild-to-moderate) DED patients based on International Task Force Delphi Panel severity grading, and controls, documented baseline measures (including tear film biomarkers and quality of life). Tear cytokine concentrations were also measured in the tear film. Patients were using artificial tears as needed. Two hundred seventeen DED patients and 67 gender- and age-matched controls were enrolled. A majority were females and Caucasian and groups did not differ significantly in terms of gender, race, or age. Differences between DED and matched controls, at baseline, included mean scores for Ocular Surface Disease Index (31.7 vs 4.1, P eye care practitioners in mild to moderate DED patients compared to normal subjects of similar ages and genders. ClinicalTrials.gov NCT00833235 on January 30, 2009.

Design study on divertor plates of Large Helical Device (LHD)

International Nuclear Information System (INIS)

Noda, N.; Kubota, Y.; Sagara, A.

1992-10-01

A conceptual design has been completed for the divertor plates of the Large Helical Device (LHD, R = 3.9 m, a p = 50 ∼ 60 cm, B h = 3 ∼ 4T/ superconducting coils of NbTi) and the detailed technical design is now in progress. The design concept and the status of research and development (R and D) programs are described. (author)

Structural Design Feasibility Study for the Global Climate Experiment

Energy Technology Data Exchange (ETDEWEB)

Lewin,K.F.; Nagy, J.

2008-12-01

Neon, Inc. is proposing to establish a Global Change Experiment (GCE) Facility to increase our understanding of how ecological systems differ in their vulnerability to changes in climate and other relevant global change drivers, as well as provide the mechanistic basis for forecasting ecological change in the future. The experimental design was initially envisioned to consist of two complementary components; (A) a multi-factor experiment manipulating CO{sub 2}, temperature and water availability and (B) a water balance experiment. As the design analysis and cost estimates progressed, it became clear that (1) the technical difficulties of obtaining tight temperature control and maintaining elevated atmospheric carbon dioxide levels within an enclosure were greater than had been expected and (2) the envisioned study would not fit into the expected budget envelope if this was done in a partially or completely enclosed structure. After discussions between NEON management, the GCE science team, and Keith Lewin, NEON, Inc. requested Keith Lewin to expand the scope of this design study to include open-field exposure systems. In order to develop the GCE design to the point where it can be presented within a proposal for funding, a feasibility study of climate manipulation structures must be conducted to determine design approaches and rough cost estimates, and to identify advantages and disadvantages of these approaches including the associated experimental artifacts. NEON, Inc requested this design study in order to develop concepts for the climate manipulation structures to support the NEON Global Climate Experiment. This study summarizes the design concepts considered for constructing and operating the GCE Facility and their associated construction, maintenance and operations costs. Comparisons and comments about experimental artifacts, construction challenges and operational uncertainties are provided to assist in selecting the final facility design. The overall goal

Approximal secondary caries lesion progression, a 20-week in situ study

NARCIS (Netherlands)

Thomas, R. Z.; Ruben, J. L.; ten Bosch, J. J.; Fidler, V.; Huysmans, M. C. D. N. J. M.

2007-01-01

There is no consensus about the definition and progression of outer and wall lesions in secondary caries. In this study we investigated whether lesion progression is influenced by an adjacent composite restoration and whether wall lesions develop at the composite-tooth interface. In order to study

A learning progression based teaching module on the causes of seasons

International Nuclear Information System (INIS)

Galano, S.

2016-01-01

In this paper, we report about designing and validating a teaching learning module based on a learning progression and focused on the causes of seasons. An initial learning progression about the Celestial Motion big idea —causes of seasons, lunar and solar eclipse and Moon phases— was developed and validated. Existing curricula, research studies on alternative conceptions about these phenomena, and students’ answers to an open questionnaire were the starting point to develop initial learning progressions; then, a two-tier multiple-choice questionnaire was designed to validate and improve it. The questionnaire was submitted to about 300 secondary-school students whose answers were used to revise the hypothesized learning progressions. This improved version of the learning progression was used to design a module focused on the causes of seasons in which students were engaged in quantitative measurements with a photovoltaic panel to explain changes of the Sun rays’ flow on the Earth’s surface over the year. The efficacy of our module in improving students’ understanding of the phenomenon of the seasons was tested using our questionnaire as pre- and post-test.

In silico design and biological evaluation of a dual specificity kinase inhibitor targeting cell cycle progression and angiogenesis.

Directory of Open Access Journals (Sweden)

Antony M Latham

Full Text Available Protein kinases play a central role in tumor progression, regulating fundamental processes such as angiogenesis, proliferation and metastasis. Such enzymes are an increasingly important class of drug target with small molecule kinase inhibitors being a major focus in drug development. However, balancing drug specificity and efficacy is problematic with off-target effects and toxicity issues.We have utilized a rational in silico-based approach to demonstrate the design and study of a novel compound that acts as a dual inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2 and cyclin-dependent kinase 1 (CDK1. This compound acts by simultaneously inhibiting pro-angiogenic signal transduction and cell cycle progression in primary endothelial cells. JK-31 displays potent in vitro activity against recombinant VEGFR2 and CDK1/cyclin B proteins comparable to previously characterized inhibitors. Dual inhibition of the vascular endothelial growth factor A (VEGF-A-mediated signaling response and CDK1-mediated mitotic entry elicits anti-angiogenic activity both in an endothelial-fibroblast co-culture model and a murine ex vivo model of angiogenesis.We deduce that JK-31 reduces the growth of both human endothelial cells and human breast cancer cells in vitro. This novel synthetic molecule has broad implications for development of similar multi-kinase inhibitors with anti-angiogenic and anti-cancer properties. In silico design is an attractive and innovative method to aid such drug discovery.

Fusion power plant simulations: a progress report

International Nuclear Information System (INIS)

Cook, J.M.; Pattern, J.S.; Amend, W.E.

1976-01-01

The objective of the fusion systems analysis at ANL is to develop simulations to compare alternative conceptual designs of magnetically confined fusion power plants. The power plant computer simulation progress is described. Some system studies are also discussed

Advanced Turbine Systems (ATS) program conceptual design and product development. Quarterly progress report, December 1, 1995--February 29, 1996

Energy Technology Data Exchange (ETDEWEB)

NONE

1997-06-01

This report describes the overall program status of the General Electric Advanced Gas Turbine Development program, and reports progress on three main task areas. The program is focused on two specific products: (1) a 70-MW class industrial gas turbine based on the GE90 core technology, utilizing a new air cooling methodology; and (2) a 200-MW class utility gas turbine based on an advanced GE heavy-duty machine, utilizing advanced cooling and enhancement in component efficiency. The emphasis for the industrial system is placed on cycle design and low emission combustion. For the utility system, the focus is on developing a technology base for advanced turbine cooling while achieving low emission combustion. The three tasks included in this progress report are on: conversion to a coal-fueled advanced turbine system, integrated program plan, and design and test of critical components. 13 figs., 1 tab.

Progressive Development of Creative Design Skills from Kindergarden Education

Directory of Open Access Journals (Sweden)

Meryem Yalcin

2015-07-01

Full Text Available This article offers an alternative view of design education, emphasising on its introduction in kindergarten and proposing a curriculum that covers design issues for introduction in kinder­gar­ten. This approach is suited to developing creative thinking skills. In an environ­ment where children imagine, create, practice, modify, recognise, manipulate and share knowl­edge, experiences and objects are crucial in design education. Early childhood education should be advanced based on basic design issues—such as design principles, conceptuali­zation, 2D/3D spatial allocation and composition—more comprehensively, which will enable children to construct perceptual, critical and analytic view points at an early age and develop these perspectives in the future. Based on this argument, the study model for design education in kindergarten, which will instil in children strong design knowledge, as well as stimulate their cognitive development. 

Progress on the design of the polarized Medium-energy Electron Ion Collider at JLAB

Energy Technology Data Exchange (ETDEWEB)

Lin, F.; Bogacz, A.; Brindza, P.; Camsonne, A.; Daly, E.; Derbenev, Ya. S.; Douglas, D.; Ent, R.; Gaskell, D.; Geng, R.; Grames, J.; Guo, J.; Harwood, L.; Hutton, A.; Jordan, K.; Kimber, A.; Krafft, G.; Li, R.; Michalski, T.; Morozov, V. S.; Nadel-Turonski, P.; /Jefferson Lab /Argonne /DESY /Moscow , Inst. Phys. Tech., Dolgoprydny /Dubna, JINR /Northern Illinois U. /Old Doominion U. /Novosibirsk, GOO Zaryad /SLAC /Texas A-M

2015-07-14

The Medium-energy Electron Ion Collider (MEIC) at JLab is designed to provide high luminosity and high polarization needed to reach new frontiers in the exploration of nuclear structure. The luminosity, exceeding 10³³ cm^-2s^-1 in a broad range of the center-of-mass (CM) energy and maximum luminosity above 10³⁴ cm^-2s^-1, is achieved by high-rate collisions of short small-emittance low-charge bunches made possible by high-energy electron cooling of the ion beam and synchrotron radiation damping of the electron beam. The polarization of light ion species (p, d, ³He) can be easily preserved and manipulated due to the unique figure-8 shape of the collider rings. A fully consistent set of parameters have been developed considering the balance of machine performance, required technical development and cost. This paper reports recent progress on the MEIC accelerator design including electron and ion complexes, integrated interaction region design, figure-8-ring-based electron and ion polarization schemes, RF/SRF systems and ERL-based high-energy electron cooling. Luminosity performance is also presented for the MEIC baseline design.

A meta-analysis on progressive atrophy in intractable temporal lobe epilepsy

Science.gov (United States)

Caciagli, Lorenzo; Bernasconi, Andrea; Wiebe, Samuel; Koepp, Matthias J.; Bernasconi, Neda

2017-01-01

Objective: It remains unclear whether drug-resistant temporal lobe epilepsy (TLE) is associated with cumulative brain damage, with no expert consensus and no quantitative syntheses of the available evidence. Methods: We conducted a systematic review and meta-analysis of MRI studies on progressive atrophy, searching PubMed and Ovid MEDLINE databases for cross-sectional and longitudinal quantitative MRI studies on drug-resistant TLE. Results: We screened 2,976 records and assessed eligibility of 248 full-text articles. Forty-two articles met the inclusion criteria for quantitative evaluation. We observed a predominance of cross-sectional studies, use of different clinical indices of progression, and high heterogeneity in age-control procedures. Meta-analysis of 18/1 cross-sectional/longitudinal studies on hippocampal atrophy (n = 979 patients) yielded a pooled effect size of r = −0.42 for ipsilateral atrophy related to epilepsy duration (95% confidence interval [CI] −0.51 to −0.32; p 80% of articles reported duration-related progression in extratemporal cortical and subcortical regions. Detailed analysis of study design features yielded low to moderate levels of evidence for progressive atrophy across studies, mainly due to dominance of cross-sectional over longitudinal investigations, use of diverse measures of seizure estimates, and absence of consistent age control procedures. Conclusions: While the neuroimaging literature is overall suggestive of progressive atrophy in drug-resistant TLE, published studies have employed rather weak designs to directly demonstrate it. Longitudinal multicohort studies are needed to unequivocally differentiate aging from disease progression. PMID:28687722

Design studies of low-aspect ratio quasi-omnigenous stellarators

International Nuclear Information System (INIS)

Spong, D.A.; Hirshman, S.; Whitson, J.C.

2001-01-01

Significant progress has been made in the development of new modest-size compact stellarator devices that could test optimization principles for the design of a more attractive reactor. These are 3 and 4 field period low-aspect-ratio quasi-omnigenous (QO) stellarators based on an optimization method that targets improved confinement, stability, ease of coil design, low-aspect-ratio, and low bootstrap current. (author)

Experimental studies on the Auburn Torsatron: Progress report

International Nuclear Information System (INIS)

Gandy, R.F.; Swanson, D.G.

1987-10-01

Progress on the Auburn Torsatron is discussed in this report. In particular, experiments are described dealing with methods of surface mapping the magnetic configuration, plasma confinement studies, ion cyclotron heating and modification to the device

Designing and implementing a longitudinal study of children with neurological, genetic or metabolic conditions: charting the territory

Directory of Open Access Journals (Sweden)

Davies Betty

2010-09-01

Full Text Available Abstract Background Children with progressive metabolic, neurological, or chromosomal conditions and their families anticipate an unknown lifespan, endure unstable and often painful symptoms, and cope with erratic emotional and spiritual crises as the condition progresses along an uncertain trajectory towards death. Much is known about the genetics and pathophysiology of these diseases, but very little has been documented about the trajectory of symptoms for children with these conditions or the associated experience of their families. A longitudinal study design will help to close this gap in knowledge. Methods/Design Charting the Territory is a longitudinal descriptive, correlational study currently underway with children 0-19 years who are diagnosed with progressive neurological, metabolic, or chromosomal conditions and their families. The purpose of the study is to determine and document the clinical progression of the condition and the associated bio-psychosocial-spiritual experiences of the parents and siblings age 7-18 years. Approximately 300 families, both newly diagnosed children and those with established conditions, are being recruited in six Canadian cities. Children and their families are being followed for a minimum of 18 months, depending on when they enroll in the study. Family data collection will continue after the child's death if the child dies during the study period. Data collection includes monthly parental assessment of the child's symptoms; an annual functional assessment of the child; and completion of established instruments every 6 months by parents to assess family functioning, marital satisfaction, health status, anxiety, depression, stress, burden, grief, spirituality, and growth, and by siblings to assess coping and health. Impact of participation on parents is assessed after 1 year and at the end of the study. Chart reviews are conducted at enrollment and at the conclusion of the study or at the time of the

THE EFFECTS OF SINGLE LEG HOP PROGRESSION AND DOUBLE LEGS HOP PROGRESSION EXERCISE TO INCREASE SPEED AND EXPLOSIVE POWER OF LEG MUSCLE

Directory of Open Access Journals (Sweden)

Nining W. Kusnanik

2015-05-01

Full Text Available The main purpose of this study was to determine the effect of single leg hop progression and double legs hop progression exercise to increase speed and explosive power of leg muscles. Plyometric is one of the training methods that can increase explosive power. There are many models of plyometric training including single leg hop progression and double leg hop progression. This research was experimental using match subject design techniques. The subjects of this study were 39 students who joined basketball school club. There were 3 groups in this study: Group 1 were 13 students who given sin¬gle leg hop progression exercise, Group 2 were 13 students who given double legs hop progression exercise, Group 3 were 13 students who given conventional exercise. The data was collected during pre test and post test by testing 30m speed running and vertical jump. The data was analyzed using Analysis of Varians (Anova. It was found that there were significantly increased on speed and explosive power of leg muscles of Group 1 and Group 2. It can be stated that single leg hop progression exercise was more effective than double leg hop progression exercise. The recent findings supported the hypothesis that single leg hop progression and double legs hop progression exercise can increase speed and explosive power of leg muscles. These finding were supported by some previous studies (Singh, et al, 2011; Shallaby, H.K., 2010. The single leg hop progression is more effective than double legs hop progression. This finding was consistent with some previous evidences (McCurdy, et al, 2005; Makaruk et al, 2011.

The influence of anxiety on the progression of disability

NARCIS (Netherlands)

Brenes, G.A.; Guralnik, J.M.; Williamson, J.D.; Fried, L.P.; Simpson, C.; Simonsick, E.M.; Penninx, B.W.J.H.

2005-01-01

OBJECTIVES: To determine the influence of anxiety on the progression of disability and examine possible mediators of the relationship. DESIGN: Community-based observational study. SETTING: Women's Health and Aging Study I, a prospective observational study with assessments every 6 months for 3

GT-MHR COMMERCIALIZATION STUDY TECHNICAL PROGRESS AND COST MANAGEMENT REPORT FOR THE PERIOD AUGUST 1 THROUGH AUGUST 31, 2003

International Nuclear Information System (INIS)

Shenoy, A.S.

2003-01-01

OAK A271 GT-MHR COMERCIALiZATION STUDY TECHNICAL PROGRESS AND COST MANAGEMENT REPORT FOR THE PERIOD AUGUST 1 THROUGH AUGUST 31, 2003. In the process of fabricating the MHR-1 irradiation test capsule, Petten has advised that three thermocouples (out of 24) and the Self Powered Neutron detector were damaged during high temperature brazing with the upper capsule lid. Procurement of new TCs and SPN is in process but there will be a delay in the irradiation test of about nine weeks. Startup of the irradiation is now projected to be July or August 2004. In preparation for performing the nuclear design analysis activities required by the advanced fuel studies task, a complete 3-D nuclear design analysis is first being performed of the GT-MHR reference design. This will serve as the baseline for studies of the advanced fuel nuclear design performance

Progress of design studies on an LHD-type steady-state reactor

International Nuclear Information System (INIS)

Motojima, O.; Komori, A.; Sagara, A.

2007-01-01

Helical Heliotrons such as the Large Helical Device (LHD) and Stellarators (H and S systems) have a high potential to realize a current-less steady-state and stable magnetic fusion energy reactor as an alternative to the tokamak DEMO-reactor. H and S systems ideally have an intrinsic property of Q=infinite. Here it is very important to remember that the understanding of the physics of 3-D toroidal magnetic confinement system is naturally extended to tokamak systems. The physics is universal among these two types of systems and the technology is common. We present our recent results from LHD experiments and reactor studies of a next generation LHD-type DEMO Reactor called FFHR. (1) Development of 3-D superconducting (SC) coil technology Due to the successful results of the LHD construction from 1990 to 2007, and steady operation over 8 years from 1998 to 2007, more than 2,000 hrs/year at a high field of around 3 Tesla, we have a large enough data base to demonstrate that 3D coil technology has become the standard technology for a fusion energy reactor. LHD is the largest SC fusion device in the world, contributing to the development of the SC technology necessary for fusion research. The poloidal coils of LHD adopted a super critical forced flow cooling system and their dimensions are almost the same as the ITER toroidal coils. (2) Extended physics understanding of high beta, high T, high n τT , and steady state operation Recent LHD experiments have demonstrated the broad and advanced capabilities of LHD as a toroidal magnetic confinement device, which are highlighted by the achievements of 5% volume averaged beta, electron and ion temperatures of 10 keV, super high density of 10E15/cc and 1 hr discharges. We plan to increase the heating power up to 35 MW, and to use deuterium gas for confinement improvement. The n τT will be improved to the design nominal value of Q=0.3 within several years and ultimately would approach unity. The key issue for this is the

Incidence and progression rates of age-related maculopathy: the Rotterdam Study

NARCIS (Netherlands)

J.J.M. Willemse-Assink (Jacqueline); R. van Leeuwen (Redmer); R.C.W. Wolfs (Roger); J.R. Vingerling (Hans); Th. Stijnen (Theo); P.T.V.M. de Jong (Paulus); C.C.W. Klaver (Caroline); A. Hofman (Albert)

2001-01-01

textabstractPURPOSE: To describe the incidence rate of age-related macular degeneration (AMD) and the progression rates of early stages of age-related maculopathy (ARM), and to study the hierarchy of fundus features that determine progression. METHODS: A group of 4953 subjects

Transitions Study of predictors of illness progression in young people with mental ill health: study methodology.

Science.gov (United States)

Purcell, R; Jorm, A F; Hickie, I B; Yung, A R; Pantelis, C; Amminger, G P; Glozier, N; Killackey, E; Phillips, L; Wood, S J; Mackinnon, A; Scott, E; Kenyon, A; Mundy, L; Nichles, A; Scaffidi, A; Spiliotacopoulos, D; Taylor, L; Tong, J P Y; Wiltink, S; Zmicerevska, N; Hermens, Daniel; Guastella, Adam; McGorry, P D

2015-02-01

An estimated 75% of mental disorders begin before the age of 24 and approximately 25% of 13-24-year-olds are affected by mental disorders at any one time. To better understand and ideally prevent the onset of post-pubertal mental disorders, a clinical staging model has been proposed that provides a longitudinal perspective of illness development. This heuristic model takes account of the differential effects of both genetic and environmental risk factors, as well as markers relevant to the stage of illness, course or prognosis. The aim of the Transitions Study is to test empirically the assumptions that underpin the clinical staging model. Additionally, it will permit investigation of a range of psychological, social and genetic markers in terms of their capacity to define current clinical stage or predict transition from less severe or enduring to more severe and persistent stages of mental disorder. This paper describes the study methodology, which involves a longitudinal cohort design implemented within four headspace youth mental health services in Australia. Participants are young people aged 12-25 years who have sought help at headspace and consented to complete a comprehensive assessment of clinical state and psychosocial risk factors. A total of 802 young people (66% female) completed baseline assessments. Annual follow-up assessments have commenced. The results of this study may have implications for the way mental disorders are diagnosed and treated, and progress our understanding of the pathophysiologies of complex mental disorders by identifying genetic or psychosocial markers of illness stage or progression. © 2013 Wiley Publishing Asia Pty Ltd.

Progress on traveling-wave reactor design

International Nuclear Information System (INIS)

Gilleland, John

2009-01-01

TerraPower LLC is leading a collaborative effort to develop physics and engineering designs for several kinds of sodium-cooled traveling-wave reactors. This collaboration includes nuclear engineering groups at TerraPower, M.I.T., U.N.L.V., Argonne National Laboratory, and the Columbia River Basin Consulting Group, as well as individual consultants from Lawrence Livermore National Laboratory, U.C. Berkeley, and several other institutions. The goal of this initiative is to develop innovative technologies that will enable cost-effective breed-and-burn reactors, which produce electricity from fuel composed almost wholly of depleted uranium. We will present conceptual designs ranging in reactor vessel size from five meters to 13 meters and in output from about 100 MWe to more than 1,000 MWe. Our Monte Carlo simulations for these reactors predict refueling intervals ranging from 40 to 125 years. Scaling designs from small to large sizes requires a shift in basic design approach; lessons learned from this effort will be discussed. We will also share our evolving understanding of the ways in which the core design can be simplified by improvements to certain limiting technologies. (author)

Nuclear powered satellite studies. Annual progress report, July 1, 1977--June 30, 1978

International Nuclear Information System (INIS)

Kaplan, M.H.

1978-06-01

Progress achieved during the reporting period is reported. Discussions of several pertinent aspects are included, e.g., schedule, personnel, technology developments, and plans. The reporting period represents the second year of activities of a project which is designed to provide continuing support in the area of nuclear space power technology. Important results are summarized

Polymer based flapping-wing robotic insect: Progress in design, fabrication, and characterization

Science.gov (United States)

Bontemps, A.; Vanneste, T.; Soyer, C.; Paquet, J. B.; Grondel, S.; Cattan, E.

2014-03-01

In the last decade, many researchers pursued the development of tiny flying robots inspired by natural flyers destined for the exploration of confined spaces, for example. Within this context, our main objective is to devise a flying robot bioinspired from insect in terms of size and wing kinematics using MEMS technologies. For this purpose, an original design has been developed around resonant thorax and wings by the way of an indirect actuation and a concise transmission whereas the all-polymer prototypes are obtained using a micromachining SU-8 photoresist process. This paper reports our recent progress on the design of a flapping-wing robotic insect as well as on the characterization of its performance. Prototypes with a wingspan of 3 cm and a mass of 22 mg are achieved. Due to the introduction of an innovative compliant link, large and symmetrical bending angles of 70° are obtained at a flapping frequency of 30 Hz along with passive wing torsion while minimizing its energy expenditure. Furthermore, it leads to a mean lift force representing up to 75 % of the prototype weight as measured by an in-house force sensor. Different improvements are currently underway to increase the power-to-weight ratio of the prototype and to obtain an airborne prototype.

Progress in studies on nucleolus functions

International Nuclear Information System (INIS)

Chang Lei; Zhou Guangming

2011-01-01

Nucleoli is the sites for ribosome synthesis and processing, however, recent approaches have revealed that it is also involved in variety of cellular processes, especially the cellular stress response. As sensors, nucleoli regulate the localization of nucleolar proteins, such as (Alternate Reading Frame, ARF), and the activation of key factors, such as P53, and consequently mediate the cellular stress response.In this paper, recent progress in the studies on nucleolar functions in cellular stress response to radiation is reviewed. (authors)

Improving human reliability through better nuclear power plant system design. Progress report

International Nuclear Information System (INIS)

Golay, M.W.

1995-01-01

The project on open-quotes Development of a Theory of the Dependence of Human Reliability upon System Designs as a Means of Improving Nuclear Power Plant Performanceclose quotes has been undertaken in order to address the important problem of human error in advanced nuclear power plant designs. Most of the creativity in formulating such concepts has focused upon improving the mechanical reliability of safety related plant systems. However, the lack of a mature theory has retarded similar progress in reducing the likely frequencies of human errors. The main design mechanism used to address this class of concerns has been to reduce or eliminate the human role in plant operations and accident response. The plan of work being pursued in this project is to perform a set of experiments involving human subject who are required to operate, diagnose and respond to changes in computer-simulated systems, relevant to those encountered in nuclear power plants. In the tests the systems are made to differ in complexity in a systematic manner. The computer program used to present the problems to be solved also records the response of the operator as it unfolds. Ultimately this computer is also to be used in compiling the results of the project. The work of this project is focused upon nuclear power plant applications. However, the persuasiveness of human errors in using all sorts of electromechanical machines gives it a much greater potential importance. Because of this we are attempting to pursue our work in a fashion permitting broad generalizations

Conceptual design study of fusion experimental reactor (FY86 FER)

International Nuclear Information System (INIS)

Seki, Yasushi; Iida, Hiromasa; Honda, Tsutomu.

1987-08-01

This report describes the study on safety for FER(Fusion Experimental Reactor) which has been designed as a next step machine to the JT-60. Though the final purpose of this study is to have an image of design base accident, maximum credible accident and to assess their risk or probability, etc., as FER plant system, the emphasis of this years study is placed on fuel-gas circulation system where the tritium inventory is maximum. This report consists of two chapters. The first chapter of this report summaries the FER system and describes FMEA(Failure Mode and Effect Analysis) and related accident progression sequence for FER plant system as a whole. The second chapter of this report is focused on fuel-gas circulation system including the purification, isotope separation system and storage system. Here, probability of risk is assessed by the probabilistic risk analysis (PRA) procedure based on FMEA, ETA and FTA. (author)

Use of simplified PSA studies in support of the ASTRID design process

International Nuclear Information System (INIS)

Gauthe, P.; Curnier, F.; Bertrand, F.; Vincon, L.; Jouve, S.; Balmain, M.; Rychkov, V.; Banchieri, Y.

2012-01-01

In the framework of the French Act of 28 June 2006 about nuclear materials and waste management, a GEN IV and actinides incineration demonstration prototype is to be commissioned in the 2020 decade. In this objective a prototype called ASTRID (Advanced Sodium Technological Reactor for Industrial Demonstration) is proposed to demonstrate the progress made in SFR technology at an industrial scale by qualifying innovative options, some of which still remain open in the areas requiring improvements, especially safety and operability. More specifically, we aim for a level of safety that is at least equivalent to that of the EPR (third generation), with improvements made in SFR-specific fields. The integration of safety issues in the early phase of the design of ASTRID is necessarily expected. For this purpose, CEA and its partners AREVA and EDF have planned to perform a level-1 PSA to support and orientate the preliminary design of ASTRID reactor. This paper presents the PSA approach and current studies for the assessment of safety systems and the future work to be done for the 2012-2014 period. The preliminary preparation of PSA studies is presented: objectives and scope of the early design phase PSA, definition of core damage states, selection and grouping of initiating events, assessment of safety functions and related systems. Work under progress is also presented: modelling of event trees, construction of fault trees of safety systems, transient calculations of accident sequences with the CATHARE2 code and reliability data assessment. Main objectives of a level-1 PSA performed at conceptual design stage are an early assessment of the safety architecture of the reactor and findings about the most effective areas for improvement, but also the identification of dominant accident sequences and comparison with alternative designs. After the elaboration of a simplified level-1 PSA model for nominal state and main internal initiators, various design alternatives will be

Large-scale identification of clinical and genetic predictors of motor progression in patients with newly diagnosed Parkinson's disease: a longitudinal cohort study and validation.

Science.gov (United States)

Latourelle, Jeanne C; Beste, Michael T; Hadzi, Tiffany C; Miller, Robert E; Oppenheim, Jacob N; Valko, Matthew P; Wuest, Diane M; Church, Bruce W; Khalil, Iya G; Hayete, Boris; Venuto, Charles S

2017-11-01

Better understanding and prediction of progression of Parkinson's disease could improve disease management and clinical trial design. We aimed to use longitudinal clinical, molecular, and genetic data to develop predictive models, compare potential biomarkers, and identify novel predictors for motor progression in Parkinson's disease. We also sought to assess the use of these models in the design of treatment trials in Parkinson's disease. A Bayesian multivariate predictive inference platform was applied to data from the Parkinson's Progression Markers Initiative (PPMI) study (NCT01141023). We used genetic data and baseline molecular and clinical variables from patients with Parkinson's disease and healthy controls to construct an ensemble of models to predict the annual rate of change in combined scores from the Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) parts II and III. We tested our overall explanatory power, as assessed by the coefficient of determination (R 2 ), and replicated novel findings in an independent clinical cohort from the Longitudinal and Biomarker Study in Parkinson's disease (LABS-PD; NCT00605163). The potential utility of these models for clinical trial design was quantified by comparing simulated randomised placebo-controlled trials within the out-of-sample LABS-PD cohort. 117 healthy controls and 312 patients with Parkinson's disease from the PPMI study were available for analysis, and 317 patients with Parkinson's disease from LABS-PD were available for validation. Our model ensemble showed strong performance within the PPMI cohort (five-fold cross-validated R 2 41%, 95% CI 35-47) and significant-albeit reduced-performance in the LABS-PD cohort (R 2 9%, 95% CI 4-16). Individual predictive features identified from PPMI data were confirmed in the LABS-PD cohort. These included significant replication of higher baseline MDS-UPDRS motor score, male sex, and increased age, as well as a novel Parkinson's disease

Inhibiting the Progression of Arterial Calcification with Vitamin K in HemoDialysis Patients (iPACK-HD Trial: Rationale and Study Design for a Randomized Trial of Vitamin K in Patients with End Stage Kidney Disease

Directory of Open Access Journals (Sweden)

Rachel M Holden

2015-05-01

Full Text Available Background: Cardiovascular disease, which is due in part to progressive vascular calcification, is the leading cause of death among patients with end stage kidney disease (ESKD on dialysis. A role for vitamin K in the prevention of vascular calcification is plausible based on the presence of vitamin K dependent proteins in vascular tissue, including matrix gla protein (MGP. Evidence from animal models and observational studies support a role for vitamin K in the prevention of vascular calcification. A large-scale study is needed to investigate the effect of vitamin K supplementation on the progression of vascular calcification in patients with ESKD, a group at risk for sub-clinical vitamin K deficiency. Methods/Design: We plan a prospective, randomized, double-blind, multicenter controlled trial of incident ESKD patients on hemodialysis in centers within North America. Eligible subjects with a baseline coronary artery calcium score of greater than or equal to 30 Agatston Units, will be randomly assigned to either the treatment group (10 mg of phylloquinone three times per week or to the control group (placebo administration three times per week. The primary endpoint is the progression of coronary artery calcification defined as a greater than 15% increase in CAC score over baseline after 12 months. Discussion: Vitamin K supplementation is a simple, safe and cost-effective nutritional strategy that can easily be integrated into patient care. If vitamin K reduces the progression of coronary artery calcification it may lead to decreased morbidity and mortality in men and women with ESKD. Trial registration: NCT 01528800.

Studies of carbon--isotope fractionation. Annual progress report, December 1, 1974--November 30, 1975

International Nuclear Information System (INIS)

Ishida, T.

1975-01-01

The vapor pressure isotope effect of 13 C/ 12 C-substitution in CClF 3 was measured at temperatures between 169 0 and 206 0 K by means of cryogenic distillation. The 13 C/ 12 C-vapor pressure isotope effect in CHF 3 was also studied at temperatures between 161 0 and 205 0 K by a similar method. The construction of a cryostat has progressed as scheduled. The investigation of carbon isotope exchange equilibria between carbon dioxide and various carbamates dissolved in various organic solvents has continued. The five-stage system of Taylor-Ghate design was improved to shorten the transient time. A single stage apparatus was designed, built, and tested. These systems are used to measure the equilibrium constants and various phase equilibria involved in the carbon dioxide--carbamate system. The investigation of the explicit method of total isotope effect has made progress. A satisfactory approximation was found for the classical partition function of a Morse oscillator. The method gives a reasonable result at rho identical with 1 / 2 √(u/sub e//x/sub e/) greater than 1.5. The medium cluster approach was applied to isotopic methanes to investigate the effects of intermolecular distance and mutual orientations of molecules in the liquid upon vapor pressure isotope effect. It was found that all geometrical effects studied tend to vanish as the size of clusters is increased. Isotope effect in the zero-point energy shifts on condensation was calculated on the basis of London dispersion forces in liquid and a semi-empirical molecular orbital theory, and was favorably compared with experimental results

Progression of Stargardt Disease as Determined by Fundus Autofluorescence in the Retrospective Progression of Stargardt Disease Study (ProgStar Report No. 9).

Science.gov (United States)

Strauss, Rupert W; Muñoz, Beatriz; Ho, Alexander; Jha, Anamika; Michaelides, Michel; Cideciyan, Artur V; Audo, Isabelle; Birch, David G; Hariri, Amir H; Nittala, Muneeswar G; Sadda, SriniVas; West, Sheila; Scholl, Hendrik P N

2017-11-01

Sensitive outcome measures for disease progression are needed for treatment trials of Stargardt disease. To describe the yearly progression rate of atrophic lesions in the retrospective Progression of Stargardt Disease study. A multicenter retrospective cohort study was conducted at tertiary referral centers in the United States and Europe. A total of 251 patients aged 6 years or older at baseline, harboring disease-causing variants in ABCA4 (OMIM 601691), enrolled in the study from 9 centers between August 2, 2013, and December 12, 2014; of these patients, 215 had at least 2 gradable fundus autofluorescence images with atrophic lesion(s) present in at least 1 eye. Areas of definitely decreased autofluorescence (DDAF) and questionably decreased autofluorescence were quantified by a reading center. Progression rates were estimated from linear mixed models with time as the independent variable. Yearly rate of progression using the growth of atrophic lesions measured by fundus autofluorescence. A total of 251 participants (458 study eyes) were enrolled. Images from 386 eyes of 215 participants (126 females and 89 males; mean [SD] age, 29.9 [14.7] years; mean [SD] age of onset of symptoms, 21.9 [13.3] years) showed atrophic lesions present on at least 2 visits and were graded for 2 (156 eyes), 3 (174 eyes), or 4 (57 eyes) visits. A subset of 224 eyes (123 female participants and 101 male participants; mean [SD] age, 33.0 [15.1] years) had areas of DDAF present on at least 2 visits; these eyes were included in the estimation of the progression of the area of DDAF. At the first visit, DDAF was present in 224 eyes (58.0%), with a mean (SD) lesion size of 2.2 (2.7) mm2. The total mean (SD) area of decreased autofluorescence (DDAF and questionably decreased autofluorescence) at first visit was 2.6 (2.8) mm2. Mean progression of DDAF was 0.51 mm2/y (95% CI, 0.42-0.61 mm2/y), and of total decreased fundus autofluorescence was 0.35 mm2/y (95% CI, 0.28-0.43 mm2/y). Rates of

Using CFD as Rocket Injector Design Tool: Recent Progress at Marshall Space Flight Center

Science.gov (United States)

Tucker, Kevin; West, Jeff; Williams, Robert; Lin, Jeff; Rocker, Marvin; Canabal, Francisco; Robles, Bryan; Garcia, Robert; Chenoweth, James

2003-01-01

objectively summarize what progress has been made at MSFC in enabling CFD as an injector design tool.

Optimum study designs.

Science.gov (United States)

Gu, C; Rao, D C

2001-01-01

Because simplistic designs will lead to prohibitively large sample sizes, the optimization of genetic study designs is critical for successfully mapping genes for complex diseases. Creative designs are necessary for detecting and amplifying the usually weak signals for complex traits. Two important outcomes of a study design--power and resolution--are implicitly tied together by the principle of uncertainty. Overemphasis on either one may lead to suboptimal designs. To achieve optimality for a particular study, therefore, practical measures such as cost-effectiveness must be used to strike a balance between power and resolution. In this light, the myriad of factors involved in study design can be checked for their effects on the ultimate outcomes, and the popular existing designs can be sorted into building blocks that may be useful for particular situations. It is hoped that imaginative construction of novel designs using such building blocks will lead to enhanced efficiency in finding genes for complex human traits.

[Reaction mechanism studies of heavy ion induced nuclear reactions]: Annual progress report, October 1987

International Nuclear Information System (INIS)

Mignerey, A.C.

1987-10-01

The experiments which this group has been working on seek to define the reaction mechanisms responsible for complex fragment emission in heavy ion reactions. The reactions studied are La + La, La + Al, and La + Cu at 46.8 MeV/u; and Ne + Ag and Ne + Au reactions at 250 MeV/u. Another experimental program at the Oak Ridge Hollifield Heavy Ion Research Facility (HHIRF) is designed to measure the excitation energy division between reaction products in asymmetric deep inelastic reactions. A brief description is given of progress to date, the scientific goals of this experiment and the plastic phoswich detectors developed for this experiment

Design Team communication and Design Task Complexity, the Preference for Dialogus

NARCIS (Netherlands)

Otter, den A.F.H.J.; Emmitt, S.

2008-01-01

The way in which dialogues and group meetings affect the progress of multidisciplinary architectural design teams can be easily underestimated by managers. This is due to the importance of group meetings to review designs, share information, make decisions and hence progress the design. The aim of

World progress toward fusion energy

International Nuclear Information System (INIS)

Davies, N.A.

1989-01-01

The author discusses international progress in fusion research during the last three years. Much of the technical progress has been achieved through international collaboration in magnetic fusion research. This progress has stimulated political interest in a multinational effort, aimed at designing and possibly constructing the world's first experimental fusion reactor. This interest was reflected in recent summit-level discussions involving President Mitterand, General Secretary Gorbachev, and President Reagan. Most recently, the European Community (EC), Japan, the United States, and the U.S.S.R. have decided to begin serious preparation for taking the next step toward practical fusion energy. These parties have agreed to begin the design and supporting R and D for an International Thermonuclear Experimental Reactor (ITER) under the auspices of the International Atomic Energy Agency (IAEA). The initiation of this international program to prepare for a fusion test reactor is discussed

Memphis State University Center for Nuclear Studies progress report

International Nuclear Information System (INIS)

1976-01-01

This quarterly report outlines the progress made by the Center for Nuclear Studies at Memphis State University in the development of specialized educational programs for the nuclear industry through the month of February, 1976

Is there a causal link between knee loading and knee osteoarthritis progression? A systematic review and meta-analysis of cohort studies and randomised trials

Science.gov (United States)

Henriksen, Marius; Creaby, Mark W; Lund, Hans; Juhl, Carsten; Christensen, Robin

2014-01-01

Objective We performed a systematic review, meta-analysis and assessed the evidence supporting a causal link between knee joint loading during walking and structural knee osteoarthritis (OA) progression. Design Systematic review, meta-analysis and application of Bradford Hill's considerations on causation. Data sources We searched MEDLINE, Scopus, AMED, CINAHL and SportsDiscus for prospective cohort studies and randomised controlled trials (RCTs) from 1950 through October 2013. Study eligibility criteria We selected cohort studies and RCTs in which estimates of knee joint loading during walking were used to predict structural knee OA progression assessed by X-ray or MRI. Data analyses Meta-analysis was performed to estimate the combined OR for structural disease progression with higher baseline loading. The likelihood of a causal link between knee joint loading and OA progression was assessed from cohort studies using the Bradford Hill guidelines to derive a 0–4 causation score based on four criteria and examined for confirmation in RCTs. Results Of the 1078 potentially eligible articles, 5 prospective cohort studies were included. The studies included a total of 452 patients relating joint loading to disease progression over 12–72 months. There were very serious limitations associated with the methodological quality of the included studies. The combined OR for disease progression was 1.90 (95% CI 0.85 to 4.25; I2=77%) for each one-unit increment in baseline knee loading. The combined causation score was 0, indicating no causal association between knee loading and knee OA progression. No RCTs were found to confirm or refute the findings from the cohort studies. Conclusions There is very limited and low-quality evidence to support for a causal link between knee joint loading during walking and structural progression of knee OA. Trial registration number CRD42012003253 PMID:25031196

Longitudinal Andhra Pradesh Eye Disease Study: rationale, study design and research methodology.

Science.gov (United States)

Khanna, Rohit C; Murthy, Gudlavalleti Vs; Marmamula, Srinivas; Mettla, Asha Latha; Giridhar, Pyda; Banerjee, Seema; Shekhar, Konegari; Chakrabarti, Subhabrata; Gilbert, Clare; Rao, Gullapalli N

2016-03-01

The rationale, objectives, study design and procedures for the longitudinal Andhra Pradesh Eye Disease Study are described. A longitudinal cohort study was carried out. Participants include surviving cohort from the rural component of Andhra Pradesh Eye Disease Study. During 1996-2000, Andhra Pradesh Eye Disease Survey was conducted in three rural (n = 7771) and one urban (n = 2522) areas (now called Andhra Pradesh Eye Disease Study 1). In 2009-2010, a feasibility exercise (Andhra Pradesh Eye Disease Study 2) for a longitudinal study (Andhra Pradesh Eye Disease Study 3) was undertaken in the rural clusters only, as urban clusters no longer existed. In Andhra Pradesh Eye Disease Study 3, a detailed interview will be carried out to collect data on sociodemographic factors, ocular and systemic history, risk factors, visual function, knowledge of eye diseases and barriers to accessing services. All participants will also undergo a comprehensive eye examination including photography of lens, optic disc and retina, Optic Coherence Tomography of the posterior segment, anthropometry, blood pressure and frailty measures. Measures include estimates of the incidence of visual impairment and age-related eye disease (lens opacities, glaucoma and age-related macular degeneration) and the progression of eye disease (lens opacities and myopia) and associated risk factors. Of the 7771 respondents examined in rural areas in Andhra Pradesh Eye Disease Study 1, 5447 (70.1%) participants were traced in Andhra Pradesh Eye Disease Study 2. These participants will be re-examined. Andhra Pradesh Eye Disease Study 3 will provide data on the incidence and progression of visual impairment and major eye diseases and their associated risk factors in India. The study will provide further evidence to aid planning eye care services. © 2015 Royal Australian and New Zealand College of Ophthalmologists.

Studies of radiation and chemical toxicity. Progress report

International Nuclear Information System (INIS)

1986-01-01

Annual report for the Studies of Radiation and Chemical Toxicity Program at the University of Rochester is presented. Progress is reported on four projects: Neurobehavorial Toxicity of Organometallic Fuel Additives, Mechanisms of Permanent and Delayed Pathologic Effects of Ionizing Radiation, Solid State Radiation Chemistry of the DNA Backbone, and Pulmonary Biochemistry

Risk of initial and moderate caries lesions in primary teeth to progress to dentine cavitation

DEFF Research Database (Denmark)

Guedes, Renata S; Piovesan, Chaiana; Floriano, Isabela

2016-01-01

AIM: To investigate the risk of sound surfaces, and initial and moderate caries lesions to progress to dentine cavitation in preschool children. DESIGN: A cohort study was designed with 639 children (12-59 months old) who had been examined by visual inspection during a survey in 2010. After 2 years......, 469 children were re-examined regarding the presence of dentine cavitations. The probability of progression was calculated for sound and carious (initial and moderate lesions) surfaces. Relative risk of progression and 95% confidence intervals for each condition compared with sound surfaces were...

Maryland University sectored isochronous cyclotron (MUSIC): Progress report No. 11

Energy Technology Data Exchange (ETDEWEB)

1966-10-10

Technical progress during the past quarter has contributed to increased confidence that MUSIC will exceed its desired performance characteristics in all respects. Design studies on the magnet indicate that a field has been obtained capable of accelerating protons above the 112 MeV design objective. Initial rf study and design work indicates no major technical problems, although there are many difficult engineering problems to be solved. Center studies are just being started. Building installation and interface problems are being dealt with effectively, and no significant problems are anticipated in this area.

Radioelement studies in the oceans. Progress report, April 15, 1981-April 14, 1982

International Nuclear Information System (INIS)

Bowen, V.T.; Livingston, H.D.; Cochran, J.K.; Sholkovitz, E.R.; Hess, M.R.

1981-11-01

Progress for the report period is reported under the following section headings: bibliographic summary - 1981; cruise reports and sampling activities; abstracts of reports published, submitted, or presented at meetings; and, brief summaries of work in progress. Research in progress includes the following studies: post-depositional chemistry of radionuclides: interstitial water composition and laboratory remobilizaton studies; thorium isotope studies in seawater; radionuclide measurements on samples from ocean weather ship MIKE, in the Norwegian Sea; counting technique optimization for Cs isotopes collected by chemisorption; Pu oxidation states in the Aleutian Trench water column; intercalibrations and standard materials; and radionuclides in deep water bathypelagic biota

Development of indigenous irradiator - current progress and challenges

International Nuclear Information System (INIS)

Anwar A Rahman; Mohd Arif Hamzah; Muhd Nor Atan; Aznor Hassan; Fadil Ismail; Julia A Karim; Rosli Darmawan

2009-01-01

The development of indigenous irradiator is one of Prototype Development Center main project to support Nuclear Malaysia services. Three (3) projects have been identified and currently the status is in final stage of design. There are some issues and challenges encountered, which delayed the project progress. The paper will discuss the current progress of development and challenges faced in designing the irradiator. (Author)

Preliminary design studies on the Broad Application Test Reactor

International Nuclear Information System (INIS)

Terry, W.J.; Terry, W.K.; Ryskamp, J.M.; Jahshan, S.N.; Fletcher, C.D.; Moore, R.L.; Leyse, C.F.; Ottewitte, E.H.; Motloch, C.G.; Lacy, J.M.

1992-08-01

This report describes progress made at the Idaho National Engineering Laboratory during the first three quarters of Fiscal Year (FY) 1992 on the Laboratory-Directed Research and Development (LDRD) project to perform preliminary design studies on the Broad Application Test Reactor (BATR). This work builds on the FY-92 BATR studies, which identified anticipated mission and safety requirements for BATR and assessed a variety of reactor concepts for their potential capability to meet those requirements. The main accomplishment of the FY-92 BATR program is the development of baseline reactor configurations for the two conventional conceptual test reactors recommended in the FY-91 report. Much of the present report consists of descriptions and neutronics and thermohydraulics analyses of these baseline configurations. In addition, we considered reactor safety issues, compared the consequences of steam explosions for alternative conventional fuel types, explored a Molten Chloride Fast Reactor concept as an alternate BATR design, and examined strategies for the reduction of operating costs. Work planned for the last quarter of FY-92 is discussed, and recommendations for future work are also presented

Planning for a program design for energy environmental analysis. Progress report

International Nuclear Information System (INIS)

Denton, J.C.

The work reported in this progress report is focused on determining the proper scope of a regional assessment study program suitable for BER/ERDA. Within the tentative scope selected, a tentative set of purposes, goals, and objectives is identified for a preliminary specification of a geographical region. The initial specification of the region includes the states of Pennsylvania, New Jersey, Delaware, Maryland, and Virginia. The tentative scope of considerations for the regional assessment study program encompasses the interacting facets of environment, energy, and economic well-being of the region with the overarching goal of reconciling these facets within the decision framework of the region

Establishing Equivalence: Methodological Progress in Group-Matching Design and Analysis

Science.gov (United States)

Kover, Sara T.; Atwood, Amy K.

2013-01-01

This methodological review draws attention to the challenges faced by intellectual and developmental disabilities researchers in the appropriate design and analysis of group comparison studies. We provide a brief overview of matching methodologies in the field, emphasizing group-matching designs used in behavioral research on cognition and…

Progressive multiple sclerosis: from pathogenic mechanisms to treatment.

Science.gov (United States)

Correale, Jorge; Gaitán, María I; Ysrraelit, María C; Fiol, Marcela P

2017-03-01

During the past decades, better understanding of relapsing-remitting multiple sclerosis disease mechanisms have led to the development of several disease-modifying therapies, reducing relapse rates and severity, through immune system modulation or suppression. In contrast, current therapeutic options for progressive multiple sclerosis remain comparatively disappointing and challenging. One possible explanation is a lack of understanding of pathogenic mechanisms driving progressive multiple sclerosis. Furthermore, diagnosis is usually retrospective, based on history of gradual neurological worsening with or without occasional relapses, minor remissions or plateaus. In addition, imaging methods as well as biomarkers are not well established. Magnetic resonance imaging studies in progressive multiple sclerosis show decreased blood-brain barrier permeability, probably reflecting compartmentalization of inflammation behind a relatively intact blood-brain barrier. Interestingly, a spectrum of inflammatory cell types infiltrates the leptomeninges during subpial cortical demyelination. Indeed, recent magnetic resonance imaging studies show leptomeningeal contrast enhancement in subjects with progressive multiple sclerosis, possibly representing an in vivo marker of inflammation associated to subpial demyelination. Treatments for progressive disease depend on underlying mechanisms causing central nervous system damage. Immunity sheltered behind an intact blood-brain barrier, energy failure, and membrane channel dysfunction may be key processes in progressive disease. Interfering with these mechanisms may provide neuroprotection and prevent disability progression, while potentially restoring activity and conduction along damaged axons by repairing myelin. Although most previous clinical trials in progressive multiple sclerosis have yielded disappointing results, important lessons have been learnt, improving the design of novel ones. This review discusses mechanisms involved

Reactor primary coolant system pipe rupture study. Progress report No. 33, January--June 1975

International Nuclear Information System (INIS)

1975-10-01

The pipe rupture study is designed to extend the understanding of failure-causing mechanisms and to provide improved capability for evaluating reactor piping systems to minimize the probability of failures. Following a detailed review to determine the effort most needed to improve nuclear system piping (Phase 1), analytical and experimental efforts (Phase 2) were started in 1965. This progress report summarizes the recent accomplishments of a broad program in (a) basic fatigue crack growth rate studies focused on LWR primary piping materials in a simulated BWR primary coolant environment, (b) at-reactor tests of the effect of primary coolant environment on the fatigue behavior of piping steels, (c) studies directed at quantifying weld sensitization in Type 304 stainless steel, (d) support studies to characterize the electrochemical potential behavior of a typical BWR primary water environment and (e) special tests related to simulation of fracture surfaces characteristic of IGSCC field failures

Accelerator research studies. Progress report

International Nuclear Information System (INIS)

1984-06-01

Progress is reported in both experimental studies as well as theoretical understanding of the beam transport problem. Major highlights are: (a) the completion of the first channel section with 12 periods and two matching solenoids, (b) measurements of beam transmission and emittance in this 12-lens channel, (c) extensive analytical and numerical studies of the beam transport problem in collaboration with GSI (W. Germany), (d) detailed measurements and calculations of beam propagation through one lens with spherical aberration and space charge, and (e) completion of the emittance grids at the Rutherford-Appleton Laboratory. Our main objectives in Task B of our research program are: (a) study of collective acceleration of positive ions from a localized plasma source by an intense relativistic electron beam (IREB), (b) external control of the IREB beam front by a slow-wave structure to achieve higher ion energies - the Beam Front Accelerator (BFA) concept, (c) study of ion and electron acceleration and other applications of a plasma focus device, and (d) theoretical studies in support of (a) and (b). Our research in these areas has been oriented towards obtaining an improved understanding of the physical processes at work in these experiments and, subsequently, achieving improved performance for specific potential applications

Accelerator research studies: Progress report, Task B

International Nuclear Information System (INIS)

1985-06-01

The main objectives in Task B of the research program are summarized as follows: (1) studies of the collective acceleration of positive ions from a localized plasma source by an intense relativistic electron beam (IREB), (2) studies of ways in which external control may be achieved over the electron beam front in order to achieve higher ion energies - the Beam Front Accelerator (BFA) concept, and (3) study of electron and ion beam generation in a new kind of compact pulsed accelerator in which energy is stored inductively and switched using a plasma focus opening switch. During the past year, substantial progress was made in each of these areas. Our exploratory research on the collective acceleration of laser-produced ions has confirmed the acceleration of C, Al, and Fe ions to peak energies in excess of 10 MeV/amu. In addition, studies of the relation between collective ion acceleration and electron beam propagation in vacuum have shed new light on the experimental processes that lead to energy transfer from electrons to ions. Meanwhile, extensive progress has been made in our attempts to use analytical theory and numerical simulation to model ion acceleration in these systems. Our resultant improved understanding of the processes that limit the peak ion energy has had a profound impact on our plans for further research in this area. Studies of the Compact Pulsed Accelerator have included both ion and electron beam extraction from the device. Its potential to reduce the volume of pulse power sources by an order of magnitude has already been demonstrated, and plans are currently underway to scale the experiment up to voltages in the 1 MV range

Progress of ITER vacuum vessel

Energy Technology Data Exchange (ETDEWEB)

Ioki, K., E-mail: Kimihiro.Ioki@iter.org [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-lez-Durance (France); Bayon, A. [F4E, c/ Josep Pla, No. 2, Torres Diagonal Litoral, Edificio B3, E-08019 Barcelona (Spain); Choi, C.H.; Daly, E.; Dani, S.; Davis, J.; Giraud, B.; Gribov, Y.; Hamlyn-Harris, C.; Jun, C.; Levesy, B. [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-lez-Durance (France); Kim, B.C. [NFRI, 52 Yeoeundong Yuseonggu, Daejeon 305-333 (Korea, Republic of); Kuzmin, E. [NTC “Sintez”, Efremov Inst., 189631 Metallostroy, St. Petersburg (Russian Federation); Le Barbier, R.; Martinez, J.-M. [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-lez-Durance (France); Pathak, H. [ITER-India, A-29, GIDC Electronic Estate, Sector 25, Gandhinagar 382025 (India); Preble, J. [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-lez-Durance (France); Sa, J.W. [NFRI, 52 Yeoeundong Yuseonggu, Daejeon 305-333 (Korea, Republic of); Terasawa, A.; Utin, Yu. [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-lez-Durance (France); and others

2013-10-15

Highlights: ► This covers the overall status and progress of the ITER vacuum vessel activities. ► It includes design, R and D, manufacturing and approval process of the regulators. ► The baseline design was completed and now manufacturing designs are on-going. ► R and D includes ISI, dynamic test of keys and lip-seal welding/cutting technology. ► The VV suppliers produced full-scale mock-ups and started VV manufacturing. -- Abstract: Design modifications were implemented in the vacuum vessel (VV) baseline design in 2011–2012 for finalization. The modifications are mostly due to interface components, such as support rails and feedthroughs for the in-vessel coils (IVC). Manufacturing designs are being developed at the domestic agencies (DAs) based on the baseline design. The VV support design was also finalized and tests on scale mock-ups are under preparation. Design of the in-wall shielding (IWS) has progressed, considering the assembly methods and the required tolerances. Further modifications are required to be consistent with the DAs’ manufacturing designs. Dynamic tests on the inter-modular and stub keys to support the blanket modules are being performed to measure the dynamic amplification factor (DAF). An in-service inspection (ISI) plan has been developed and R and D was launched for ISI. Conceptual design of the VV instrumentation has been developed. The VV baseline design was approved by the agreed notified body (ANB) in accordance with the French Nuclear Pressure Equipment Order procedure.

Progress of ITER vacuum vessel

International Nuclear Information System (INIS)

Ioki, K.; Bayon, A.; Choi, C.H.; Daly, E.; Dani, S.; Davis, J.; Giraud, B.; Gribov, Y.; Hamlyn-Harris, C.; Jun, C.; Levesy, B.; Kim, B.C.; Kuzmin, E.; Le Barbier, R.; Martinez, J.-M.; Pathak, H.; Preble, J.; Sa, J.W.; Terasawa, A.; Utin, Yu.

2013-01-01

Highlights: ► This covers the overall status and progress of the ITER vacuum vessel activities. ► It includes design, R and D, manufacturing and approval process of the regulators. ► The baseline design was completed and now manufacturing designs are on-going. ► R and D includes ISI, dynamic test of keys and lip-seal welding/cutting technology. ► The VV suppliers produced full-scale mock-ups and started VV manufacturing. -- Abstract: Design modifications were implemented in the vacuum vessel (VV) baseline design in 2011–2012 for finalization. The modifications are mostly due to interface components, such as support rails and feedthroughs for the in-vessel coils (IVC). Manufacturing designs are being developed at the domestic agencies (DAs) based on the baseline design. The VV support design was also finalized and tests on scale mock-ups are under preparation. Design of the in-wall shielding (IWS) has progressed, considering the assembly methods and the required tolerances. Further modifications are required to be consistent with the DAs’ manufacturing designs. Dynamic tests on the inter-modular and stub keys to support the blanket modules are being performed to measure the dynamic amplification factor (DAF). An in-service inspection (ISI) plan has been developed and R and D was launched for ISI. Conceptual design of the VV instrumentation has been developed. The VV baseline design was approved by the agreed notified body (ANB) in accordance with the French Nuclear Pressure Equipment Order procedure

Challenges and progress in turbomachinery design systems

International Nuclear Information System (INIS)

Van den Braembussche, R A

2013-01-01

This paper first describes the requirements that a modern design system should meet, followed by a comparison between design systems based on inverse design or optimization techniques. The second part of the paper presents the way these challenges are realized in an optimization method combining an Evolutionary theory and a Metamodel. Extensions to multi-disciplinary, multi-point and multi-objective optimization are illustrated by examples

Nuclear-structure studies by the scattering of medium-energy electrons. Progress report, October 1, 1980-July 31, 1981

International Nuclear Information System (INIS)

Peterson, G.A.

1981-08-01

Electron scattering experiments are in progress at the Bates Linear Accelerator in Middleton, Massachusetts. Both magnetic elastic and transverse inelastic scattering cross sections have been measured at 180 0 by the apparatus constructed and brought into operation in late 1977 by the University of Massachusetts. A liquid-nitrogen-cooled gas target is being used in a study of deuteron elastic scattering and electrodisintegration over a large energy range. A measurement of elastic magnetic and transverse inelastic scattering from 14 N has been started. Measurements of the elastic magnetic scattering from 13 C, 15 N, 27 Al, 29 Si, and 31 P have been completed. The data set on 15 N inelastic scattering are now complete and analysis of the data is in progress. A study of M8 transitions in 54 Fe and 60 Ni is nearing completion. A measurement of the transverse quasielastic scattering from 56 Fe has been started. Planning for an experiment utilizing radioactive 14 C is underway. Large-basis shell model calculations pertaining to the above nuclei and others have been made. Theoretical calculations of exchange currents, nuclear convection currents, and other nuclear phenomena are in progress. Finally, considerations are being given to the design of an integrated storage-ring-experimental system

Conceptual design study on advanced aqueous reprocessing system for fast reactor fuel cycle

International Nuclear Information System (INIS)

Takata, Takeshi; Koma, Yoshikazu; Sato, Koji; Kamiya, Masayoshi; Shibata, Atsuhiro; Nomura, Kazunori; Ogino, Hideki; Koyama, Tomozo; Aose, Shin-ichi

2003-01-01

As a feasibility study on commercialized fast reactor cycle system, a conceptual design study is being progressed for the aqueous and pyrochemical processes from the viewpoint of economical competitiveness, efficient utilization of resources, decreasing environmental impact and proliferation resistance in Japan Nuclear Cycle Development Institute (JNC). In order to meet above-mentioned requirements, the survey on a range of reprocessing technologies and the evaluation of conceptual plant designs against targets for the future fast reactor cycle system have been implemented as the fist phase of the feasibility study. For an aqueous reprocessing process, modification of the conventional PUREX process (a solvent extraction process with purification of U/Pu, with nor recovery of minor actinides (MA)) and investigation of alternatives for the PUREX process has been carried out and design study of advanced aqueous reprocessing system and its alternatives has been conducted. The conceptual design of the advanced aqueous reprocessing system has been updated and evaluated by the latest R and D results of the key technologies such as crystallization, single-cycle extraction, centrifugal contactors, recovery of Am/Cm and waste processing. In this paper, the outline of the design study and the current status of development for advanced aqueous reprocessing system, NEXT process, are mentioned. (author)

IFMIF high flux test module - recent progress in design and manufacturing

International Nuclear Information System (INIS)

Leichtle, D.; Arbeiter, F.; Dolensky, B.

2007-01-01

The International Fusion Material Irradiation Facility (IFMIF) is an accelerator driven neutron source for irradiation tests of candidate fusion reactor materials. Two 40 MeV deuterium beams with 125 mA each strike a liquid lithium jet target, producing a high intensity neutron flux up to 55 MeV, which penetrates the adjacent test modules. Within the High Flux Test Module (HFTM) a testing volume of 0.5 litres filled by qualified small scale specimens will be irradiated at displacement rates of 20-50 dpa/fpy in structural materials. The HFTM will also provide helium and hydrogen production to dpa ratios that reflect within the uncertainties the values expected in a DEMO fusion reactor The Forschungszentrum Karlsruhe (FZK) has developed a HFTM design which closely follows the design premise of maximising the space available for irradiation specimens in the IFMIF high flux zone and in addition allows keeping the temperature nearly constant in the rigs containing the specimen. Within the entire specimen stack the temperature deviation will be below about 15 K. The main design principles applied are (i) filling the gaps between the specimens with liquid metal, (ii) winding three separately controlled heater sections on the inner capsules and (iii) dividing the test rigs in a hot inner and a cold outer zone, which a separated by a gap filled with stagnant helium that serves as a thermal insulator. Channels between the outer covers (the cold parts) are cooled by helium gas at moderate pressure (3 bars at inlet) and temperature (50 C). 12 identical rigs holding the specimen capsules which are heated by segmented helically wound electrical heaters ensure a flexible loading scheme during IFMIF operation. Complementary analyses on nuclear, thermo-hydraulics and mechanical performance of the HFTM were performed to optimize the design. The present paper highlights the main design characteristics as well as recent progress achieved in this area. This includes the stiffening of

The Heritability of Insomnia Progression during Childhood/Adolescence: Results from a Longitudinal Twin Study

Science.gov (United States)

Barclay, Nicola L.; Gehrman, Philip R.; Gregory, Alice M.; Eaves, Lindon J.; Silberg, Judy L.

2015-01-01

Study Objectives: To determine prevalence and heritability of insomnia during middle/late childhood and adolescence; examine longitudinal associations in insomnia over time; and assess the extent to which genetic and environmental factors on insomnia remain stable, or whether new factors come into play, across this developmental period. Design: Longitudinal twin study. Setting: Academic medical center. Patients or Participants: There were 739 complete monozygotic twin pairs (52%) and 672 complete dizygotic twin pairs (48%) initially enrolled and were followed up at three additional time points (waves). Mode ages at each wave were 8, 10, 14, and 15 y (ages ranged from 8–18 y). Interventions: None. Measurements and Results: Clinical ratings of insomnia symptoms were assessed using the Child and Adolescent Psychiatric Assessment (CAPA) by trained clinicians, and rated according to Diagnostic and Statistical Manual of Mental Disorders, 3rd Edition—Revised criteria for presence of “clinically significant insomnia,” over four sequential waves. Insomnia symptoms were prevalent but significantly decreased across the four waves (ranging from 16.6% to 31.2%). “Clinically significant insomnia” was moderately heritable at all waves (h2 range = 14% to 38%), and the remaining source of variance was the nonshared environment. Multivariate models indicated that genetic influences at wave 1 contributed to insomnia at all subsequent waves, and that new genetic influences came into play at wave 2, which further contributed to stability of symptoms. Nonshared environmental influences were time-specific. Conclusion: Insomnia is prevalent in childhood and adolescence, and is moderately heritable. The progression of insomnia across this developmental time period is influenced by stable as well as new genetic factors that come into play at wave 2 (modal age 10 y). Molecular genetic studies should now identify genes related to insomnia progression during childhood and

Alcohol consumption and the neoplastic progression in Barrett's esophagus: a systematic review and meta-analysis.

Directory of Open Access Journals (Sweden)

Zhifeng Lou

Full Text Available PURPOSE: In the developed countries, the incidence of esophageal adenocarcinoma (EAC is increasing over recent decades. The purpose of this meta-analysis was to arrive at quantitative conclusions about the contribution of alcohol intakes and the progression of Barrett's esophagus. METHODS: A comprehensive, systematic bibliographic search of medical literature published up to Oct 2013 was conducted to identify relevant studies. A meta-analysis was conducted for alcohol consumption on the Barrett's esophagus progression. RESULTS: A total of 882 cases in 6,867 individuals from 14 observational studies were indemnified in this meta-analysis. The result of this current meta-analysis, including 10 case-control and 4 cohort studies, indicated that alcohol consumption was not associated with the neoplastic progression in Barrett's esophagus (RR, 1.17; 95% CI, 0.93-1.48. When stratified by the study designs, no significant association was detected in either high vs low group or ever vs never group. CONCLUSIONS: Alcohol drinking is not associated with risk of neoplastic progression in Barrett's esophagus. Further well designed studies are needed in this area.

Herpes zoster, immunological deterioration and disease progression in HIV-1 infection

NARCIS (Netherlands)

Veenstra, J.; Krol, A.; van Praag, R. M.; Frissen, P. H.; Schellekens, P. T.; Lange, J. M.; Coutinho, R. A.; van der Meer, J. T.

1995-01-01

OBJECTIVE: To study the incidence of herpes zoster, the relationship between herpes zoster and immunological markers, and the prognostic value of herpes zoster for progression of HIV disease. DESIGN AND METHODS: A total of 966 homosexual participants in The Amsterdam Cohort Study were studied.

Progress Toward Heavy Ion IFE

International Nuclear Information System (INIS)

Meier, W.R.; Logan, B.G.; Waldron, W.L.; Sabbi, G.L.; Callahan-Miller, D.A.; Peterson, P.F.; Goodin, D.T.

2002-01-01

Successful development of Heavy Ion Fusion (HIF) will require scientific and technology advances in areas of targets, drivers and chambers. Design work on heavy ion targets indicates that high gain (60-130) may be possible with a -3-6 MJ driver depending on the ability to focus the beams to small spot sizes. Significant improvements have been made on key components of heavy ion drivers, including sources, injectors, insulators and ferromagnetic materials for long-pulse induction accelerator cells, solid-state pulsers, and superconducting quadrupole magnets. The leading chamber concept for HIF is the thick-liquid-wall HYLEE-II design, which uses an array of flibe jets to protect chamber structures from x-ray, debris, and neutron damage. Significant progress has been made in demonstrating the ability to create and control the types of flow needed to form the protective liquid blanket. Progress has also been made on neutron shielding for the final focus magnet arrays with predicted lifetimes now exceeding the life of the power plant. Safety analyses have been completed for the HYLEE-II design using state-of-the-art codes. Work also continues on target fabrication and injection for HE. A target injector experiment capable of > 5 Hz operation has been designed and construction will start in 2002. Methods for mass production of hohlraum targets are being evaluated with small-scale experiments and analyses. Progress in these areas will be reviewed

Progress toward heavy-ion IFE

International Nuclear Information System (INIS)

Meier, W.R.; Logan, B.G.; Waldron, W.L.; Sabbi, G.-L.; Callahan, D.A.; Peterson, P.F.; Goodin, D.T.

2002-01-01

Successful development of heavy-ion fusion (HIF) will require scientific and technology advances in areas of targets, drivers and chambers. Design work on heavy-ion targets indicates that high gain (60-130) may be possible with a ∼3-6 MJ driver depending on the ability to focus the beams to small spot sizes. Significant improvements have been made on key components of heavy-ion drivers, including sources, injectors, insulators and ferromagnetic materials for long-pulse induction accelerator cells, solid-state pulsers, and superconducting quadrupole magnets. The leading chamber concept for HIF is the thick-liquid-wall HYLIFE-II design, which uses an array of flibe jets to protect chamber structures from X-ray, debris, and neutron damage. Significant progress has been made in demonstrating the ability to create and control the types of flow needed to form the protective liquid blanket. Progress has also been made on neutron shielding for the final focus magnet arrays with predicted lifetimes now exceeding the life of the power plant. Safety analyses have been completed for the HYLIFE-II design using state-of-the-art codes. Work also continues on target fabrication and injection for HIF. A target injector experiment capable of >5 Hz operation has been designed and construction will start in 2002. Methods for mass-production of hohlraum targets are being evaluated with small-scale experiments and analyses. Progress in these areas will be reviewed

High energy physics studies. Progress report. Part I. Experimental program. Part II. Theoretical program

International Nuclear Information System (INIS)

Romanowski, T.A.; Tanaka, K.; Wada, W.W.

1978-01-01

Experimental Program: assembly of an experiment as Fermilab E-531 to measure decay lifetimes, with tagged emulsion of charmed particles produced by high energy neutrinos was finished, and data taking now is in progress. An experiment to measure prompt neutrino production at Fermilab, E-613, was approved and detailed design of it is continuing. Search for parity violation in scattering of polarized protons, an experiment E-446-ZGS at ANL, was performed with the sensitivity of 10 -6 for detection of that process and yielded null results. Another run with improved sensitivity of 10 -7 is in preparation. Data analysis of the neutrino experiment E-310 at Fermilab will continue. Trimuon events, a new discovery, were identified in those data. Analysis of data on meson production from experiments performed at the ZGS--ANL, E-397, E-420 and E-428, with charged and neutral spectrometer will continue. A new relatively broad resonance (T approx. 70 MeV) with quantum numbers IJ/sup P/ = 00 -1 was discovered in the data from E-397. Analysis of beta decay of polarized Σ - hyperons is in progress. Participation in the design of the experimental areas for the Isabelle colliding proton beam accelerator will continue. Theoretical Program: topics of current interest in particle theory which will be investigated in the coming year are: the instanton-anti-instanton QCD gauge fields, discrete symmetries which may determine quark masses in the SU(2) x U(1) model, calculation of charmed meson production in e + e - collisions and formation of gluon jets, Higgs boson production in pp collisions, calculation of Higgs boson mass in terms of vector boson mass, study of Lagrangians with gauge and Higgs scalar fields, investigation of Faddeev--Popov determinants as related to quantum chromodynamics, a study of quantum flavor dynamics and anomalies in the axial vector Ward identity and a study of super symmetry as a part of a realistic model of leptonic interactions

Progress of scientific researches and project of CSR in IMP

International Nuclear Information System (INIS)

Jin Genming

2004-01-01

The article reviews the recent progress of the scientific researches including synthesis of new nuclides, investigations of the isospin effects in heavy ion collisions, studies of the nuclear structure in high spin states and the applications of heavy ion beams to other scientific researches, such as biology and material science. It also gives a brief introduction of the development of the design and progress of the new project of heavy ion cooling storage ring (CSR) of Lanzhou. (author)

The Use of Organising Purposes in Science Instruction as a Scaffolding Mechanism to Support Progressions: A Study of Talk in Two Primary Science Classrooms

Science.gov (United States)

Johansson, Annie-Maj; Wickman, Per-Olof

2018-01-01

Purpose: This study examines how different purposes can support teachers in their work with progressions as a part of a teaching sequences in science in primary school. Design/Method: The study was carried out in two classes working with inquiry and the events that took place in the classroom were filmed. In the study, we have chosen to use the…

Classifying the Progression of Ductal Carcinoma from Single-Cell Sampled Data via Integer Linear Programming: A Case Study.

Science.gov (United States)

Catanzaro, Daniele; Shackney, Stanley E; Schaffer, Alejandro A; Schwartz, Russell

2016-01-01

Ductal Carcinoma In Situ (DCIS) is a precursor lesion of Invasive Ductal Carcinoma (IDC) of the breast. Investigating its temporal progression could provide fundamental new insights for the development of better diagnostic tools to predict which cases of DCIS will progress to IDC. We investigate the problem of reconstructing a plausible progression from single-cell sampled data of an individual with synchronous DCIS and IDC. Specifically, by using a number of assumptions derived from the observation of cellular atypia occurring in IDC, we design a possible predictive model using integer linear programming (ILP). Computational experiments carried out on a preexisting data set of 13 patients with simultaneous DCIS and IDC show that the corresponding predicted progression models are classifiable into categories having specific evolutionary characteristics. The approach provides new insights into mechanisms of clonal progression in breast cancers and helps illustrate the power of the ILP approach for similar problems in reconstructing tumor evolution scenarios under complex sets of constraints.

Flexible energy-storage devices: design consideration and recent progress.

Science.gov (United States)

Wang, Xianfu; Lu, Xihong; Liu, Bin; Chen, Di; Tong, Yexiang; Shen, Guozhen

2014-07-23

Flexible energy-storage devices are attracting increasing attention as they show unique promising advantages, such as flexibility, shape diversity, light weight, and so on; these properties enable applications in portable, flexible, and even wearable electronic devices, including soft electronic products, roll-up displays, and wearable devices. Consequently, considerable effort has been made in recent years to fulfill the requirements of future flexible energy-storage devices, and much progress has been witnessed. This review describes the most recent advances in flexible energy-storage devices, including flexible lithium-ion batteries and flexible supercapacitors. The latest successful examples in flexible lithium-ion batteries and their technological innovations and challenges are reviewed first. This is followed by a detailed overview of the recent progress in flexible supercapacitors based on carbon materials and a number of composites and flexible micro-supercapacitors. Some of the latest achievements regarding interesting integrated energy-storage systems are also reviewed. Further research direction is also proposed to surpass existing technological bottle-necks and realize idealized flexible energy-storage devices. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

High doses of biotin in chronic progressive multiple sclerosis: a pilot study.

Science.gov (United States)

Sedel, Frédéric; Papeix, Caroline; Bellanger, Agnès; Touitou, Valérie; Lebrun-Frenay, Christine; Galanaud, Damien; Gout, Olivier; Lyon-Caen, Olivier; Tourbah, Ayman

2015-03-01

No drug has been found to have any impact on progressive multiple sclerosis (MS). Biotin is a vitamin acting as a coenzyme for carboxylases involved in key steps of energy metabolism and fatty acids synthesis. Among others, biotin activates acetylCoA carboxylase, a potentially rate-limiting enzyme in myelin synthesis. The aim of this pilot study is to assess the clinical efficacy and safety of high doses of biotin in patients suffering from progressive MS. Uncontrolled, non-blinded proof of concept study 23 consecutive patients with primary and secondary progressive MS originated from three different French MS reference centers were treated with high doses of biotin (100-300mg/day) from 2 to 36 months (mean=9.2 months). Judgement criteria varied according to clinical presentations and included quantitative and qualitative measures. In four patients with prominent visual impairment related to optic nerve injury, visual acuity improved significantly. Visual evoked potentials in two patients exhibited progressive reappearance of P100 waves, with normalization of latencies in one case. Proton magnetic resonance spectroscopy (H-MRS) in one case showed a progressive normalization of the Choline/Creatine ratio. One patient with left homonymous hemianopia kept on improving from 2 to 16 months following treatment׳s onset. Sixteen patients out of 18 (89%) with prominent spinal cord involvement were considered as improved as confirmed by blinded review of videotaped clinical examination in 9 cases. In all cases improvement was delayed from 2 to 8 months following treatment׳s onset. These preliminary data suggest that high doses of biotin might have an impact on disability and progression in progressive MS. Two double-blind placebo-controlled trials are on going. Copyright © 2015 The Authors. Published by Elsevier B.V. All rights reserved.

A Progressive Approach to Content Generation

DEFF Research Database (Denmark)

Shaker, Mohammad; Shaker, Noor; Togelius, Julian

2015-01-01

and the associated level design. The framework first generates timelines following the search-based paradigm. Timelines are game-independent and they reflect the rhythmic feel of the levels. A progressive, constructive-based approach is then implemented to evaluate timelines by mapping them into level designs...

The relationship between motivations of architectural designers and environmentally sustainable construction design

OpenAIRE

Murtagh, N. M.; Roberts, A.; Hind, R.

2016-01-01

Research on sustainability in construction design has tended to focus on technological, institutional and economic drivers but there has been little change in the industry. Social scientific approaches offer insights on the lack of progress. However, few previous studies have investigated psychological factors despite the pivotal role of the individual professional decision-maker. The aim was to understand what personal motivations drive architectural designers to pursue sustainable design in...

A design study of hydrogen isotope separation system for ITER-FEAT

International Nuclear Information System (INIS)

Iwai, Yasunori; Yamanishi, Toshihiko; Nishi, Masataka

2001-03-01

Preliminary design study of the hydrogen isotope separation system (ISS) for the fuel cycle of the ITER-FEAT, a fusion experimental reactor, was carried out based on the substantial reduction of hydrogen flow to the ISS resulting from the design study for scale reduction of the formerly-designed ITER. Three feed streams (plasma exhaust gas stream, streams from the water detritiation system and that from the neutral beam injectors) are fed to the ISS, and three product streams (high purity tritium gas, high purity deuterium gas and hydrogen gas) are made in it by the method of cryogenic distillation. In this study, an original four-column cascade was proposed to the ISS cryogenic distillation column system considering simplification and the operation scenario of the ITER-FEAT. Substantial reduction of tritium inventory in the ISS was found to be possible in the progress of investigation concerning of the corresponding flow rate of tritium product stream (T>90 %) for pellet injector which depends upon the operation condition. And it was found that tritium concentration in the released hydrogen stream into environment from the ISS could easily fluctuate with current design of column arrangement due to the small disturbance in mass flow balance in the ISS. To solve this problem, two-column system for treatment of this flow was proposed. (author)

Progress in fusion technology at SWIP

Energy Technology Data Exchange (ETDEWEB)

Duan, X.R., E-mail: duanxr@swip.ac.cn; Chen, J.M.; Feng, K.M.; Liu, X.; Li, B.; Wu, J.H.; Wang, X.Y.; Zheng, P.F.; Wang, Y.Q.; Wang, P.H.; Liu, Yong

2016-11-01

Highlights: • Dispersion strengthened CLF-1 steel, vanadium alloys and tungsten alloys are developed. • The HCCB TBM conceptual design, development of functional materials such as Li{sub 4}SiO{sub 4} pebbles and Be pebbles are in progress. • A full size prototype shield block has been fabricated and passed ITER qualification. • Advanced divertor for a new tokamak are designed and analyzed. • GIS and GDC have entered the engineering design phase. - Abstract: The fusion research activities at Southwestern Institute of Physics (SWIP) include the HL-2A & HL-2M tokamak programs, fusion reactor design and materials, along with key fusion technologies including R&D on ITER procurement packages. This paper presents the progress of fusion technology at SWIP, including the ITER first wall and blanket, Chinese helium cooled ceramic breeder test blanket module (HCCB–TBM) for ITER, gas injection system and gas discharge cleaning system, as well as the recent activities on reactor materials and R&D related to advanced divertor. The final design for ITER first wall and blanket shielding blocks allocated to SWIP have been completed, and were validated by recent tests. Major manufacturing technologies, such as forging, deep drilling, explosion bonding and deep laser welding, have been successfully demonstrated. Furthermore, the conceptual design of CN–HCCB–TBM has been completed, the related materials’ preparation, mock-up manufacturing and tests have been implemented. The tungsten divertor has been studied with various bonding and coating technologies. Meanwhile, highlights of functional material for TBM, oxides and carbides dispersion strengthened (ODS, CDS) reduced activation ferritic/martensitic (RAFM) steel, vanadium and tungsten alloys are also presented.

3-GROUP METAPHASE AS A MORPHOLOGIC CRITERION OF PROGRESSIVE CERVICAL INTRAEPITHELIAL NEOPLASIA

NARCIS (Netherlands)

MOURITS, MJE; PIETERS, WJLM; HOLLEMA, H; BURGER, MPM

OBJECTIVE: The purpose of our study was to investigate the presence of three-group metaphase in progressive cervical intraepithelial neoplasia. STUDY DESIGN: This was a retrospective histologic study on the conization specimens of 41 women with microinvasive cervical carcinoma, 28 of whom were

Three-group metaphase as a morphologic criterion of progressive cervical intraepithelial neoplasia

NARCIS (Netherlands)

Mourits, M. J.; Pieters, W. J.; Hollema, H.; Burger, M. P.

1992-01-01

OBJECTIVE: The purpose of our study was to investigate the presence of three-group metaphase in progressive cervical intraepithelial neoplasia. STUDY DESIGN: This was a retrospective histologic study on the conization specimens of 41 women with microinvasive cervical carcinoma, 28 of whom were

An Analysis of Stative Verbs Used with the Progressive Aspect in Corpus-Informed Textbooks

Science.gov (United States)

Belli, Serap Atasever

2018-01-01

This study was designed to investigate whether contemporary corpus-informed grammar textbooks written for English language learners and teachers presented the progressive use of stative verbs and if yes, which stative verbs were presented to occur with the progressive aspect and for which functions they took this aspect. A corpus of six electronic…

Nuclear structure studies by the scattering of medium-energy electrons. Progress report, October 1, 1980-July 31, 1981

International Nuclear Information System (INIS)

Peterson, G.A.

1981-08-01

Electron scattering experiments are in progress at the Bates Linear Accelerator in Middleton, Massachusetts. Both magnetic elastic and transverse inelastic scattering cross sections have been measured at 180 0 by the apparatus constructed and brought into operation in late 1977 by the University of Massachusetts. A liquid-nitrogen-cooled gas target is being used in a study of deuteron elastic magnetic scattering and electrodisintegration over a large energy range. A measurement of elastic magnetic and transverse inelastic scattering from 14 N has been started. Measurements of the elastic magnetic scattering from 13 C, 15 N, 27 Al, 29 Si, and 31 P have been completed. The data set on 15 N inelastic scattering are now complete and analysis of the data is in progress. A study of M8 transitions in 54 Fe and 60 Ni is nearing completion. Several papers are being written on these subjects. A measurement of the transverse quasi-elastic scattering from 56 Fe has been started. Planning for an experiment utilizing radioactive 14 C is underway. Large-basis shell model calculations pertaining to the above nuclei and others have been made. Theoretical calculations of exchange currents, nuclear convection currents, and other nuclear phenomena are in progress. Finally, considerations are being given to the design of an integrated storage-ring-experimental system

Presence of the variant mannose-binding lectin alleles associated with slower progression to AIDS. Amsterdam Cohort Study

NARCIS (Netherlands)

Maas, J.; de Roda Husman, A. M.; Brouwer, M.; Krol, A.; Coutinho, R.; Keet, I.; van Leeuwen, R.; Schuitemaker, H.

1998-01-01

OBJECTIVE: To examine the association between mannose-binding lectin (MBL) polymorphism and progression to AIDS and death in HIV-1 infection. DESIGN AND METHODS: In 131 HIV-1-infected homosexual seroconverters, survival analyses were performed to determine both the association between MBL genotype

Editorial summary: findings from a survey on the Danish study progress reform

DEFF Research Database (Denmark)

Sarauw, Laura Louise; Madsen, Simon Ryberg

The summary presents the key findings from the first comprehensive survey of what students expect of the Danish Study Progress Reform. The summarised report is based on a survey conducted among 4.354 university students, who were asked to assess how they expect to manage their time and prioritise...... their activities in light of the Study Progress Reform’s requirements for faster completion. The survey was distributed in April 2015 as part of a politically independent research project funded by the Danish Council for Independent Research/Humanities (FKK)....

Senior Design in Agricultural Engineering--Progress and Pitfalls.

Science.gov (United States)

Holmes, R. G.; Rohrbach, R. P.

1979-01-01

Describes a specific senior design course and its objectives. Explains the basic deficiencies and problems for design education in agricultural engineering. Also stresses the effect the project advisor has on students' attitudes toward design and the applications of the course. (SMB)

Progress in high gain inertial confinement fusion

International Nuclear Information System (INIS)

Sun Jingwen

2001-01-01

The author reviews the progress in laboratory high gain inertial confinement fusion (ICF), including ICF capsule physics, high-energy-density science, inertial fusion energy, the National Ignition Facility (NIF) and its design of ignition targets and the peta watt laser breakthrough. High power laser, particle beam, and pulsed power facilities around the world have established the new laboratory field of high-energy- density plasma physics and have furthered development of inertial fusion. New capabilities such as those provided by high-brightness peta watt lasers have enabled the study of matter feasible in conditions previously unachievable on earth. Science and technology developed in inertial fusion research have found near-term commercial use and have enabled steady progress toward the goal of fusion ignition and high gain in the laboratory, and have opened up new fields of study for the 21 st century

Study on advanced structural design for commercialized fast breeder reactors

International Nuclear Information System (INIS)

Morishita, Masaki; Aoto, Kazumi; Kasahara, Naoto; Asayama, Tai

2003-05-01

Japan Nuclear Cycle Development Institute (JNC) and Japan Atomic Power Company (JAPC) launched joint research programs on structural design and three-dimensional seismic isolation technologies, as part of the supporting R and D activities for the feasibility studies on commercialized fast breeder reactor cycle systems. A research project by JAPC under the auspices of the Ministry of Economy, Trade, and Industry (METI) with technical support by JNC is included in this joint study. This report contains the results of the research on the structural design technology. The research scope was identified as (1) FDS (FBR Design Standard), (2) Standardization of new material, and (3) System Based Code for Integrity, and the results of this year's studies are summarized as follows. (1) FDS (FBR Design Standard). R and D policy of Phase II study considering to the newest needs demanded for structural design were clarified, and R and D items were settled concretely. As for failure criteria, preliminary ratcheting-fatigue tests were conducted with rational methods, and Negligible Creep curves that settle creep designing region rationally were expanded their applying condition. R and D policy and items of guideline for inelastic analysis were clarified, and analyzing methodologies were studied. Summering up exemplification of thermal load prediction methodologies were progressed. To predict thermal striping loads, advanced frequency response function of thermal stress, and fatigue evaluation methodology were studied. (2) Standardization of new material. As for candidate 12-chromium stainless steel (added tungsten, non-added tungsten), that is expected to improve strength of components of commercialized FR, short and medium-term material tests, and creep-fatigue tests at small strain range were conducted. As for above candidate steel, TIG (Tungsten Inert Gas) welding method was recommended. Requirements to standardize new materials and index to select new materials were studied

SmartCanvas: Context-inferred Interpretation of Sketches for Preparatory Design Studies

KAUST Repository

Zheng, Youyi

2016-05-27

In early or preparatory design stages, an architect or designer sketches out rough ideas, not only about the object or structure being considered, but its relation to its spatial context. This is an iterative process, where the sketches are not only the primary means for testing and refining ideas, but also for communicating among a design team and to clients. Hence, sketching is the preferred media for artists and designers during the early stages of design, albeit with a major drawback: sketches are 2D and effects such as view perturbations or object movement are not supported, thereby inhibiting the design process. We present an interactive system that allows for the creation of a 3D abstraction of a designed space, built primarily by sketching in 2D within the context of an anchoring design or photograph. The system is progressive in the sense that the interpretations are refined as the user continues sketching. As a key technical enabler, we reformulate the sketch interpretation process as a selection optimization from a set of context-generated canvas planes in order to retrieve a regular arrangement of planes. We demonstrate our system (available at http:/geometry.cs.ucl.ac.uk/projects/2016/smartcanvas/) with a wide range of sketches and design studies. © 2016 The Author(s) Computer Graphics Forum © 2016 The Eurographics Association and John Wiley & Sons Ltd. Published by John Wiley & Sons Ltd.

Progress of the HTR-10 project

International Nuclear Information System (INIS)

Zhong, D.; Xu, Y.

1996-01-01

This paper briefly introduces the main technical features and the design specifications of the HTR-10. Present status and main progress of the license applications, the design and manufacture of the main components and the engineering experiments as well as the construction of the HTR-10 are summarized. (author). 3 tabs

Electron gun design study for the IUCF beam cooling system

International Nuclear Information System (INIS)

Friesel, D.L.; Ellison, T.; Jones, W.P.

1985-01-01

The design of a low temperature electron beam cooling system for the Indiana University electron-cooled storage ring is in progress. The storage ring, which will accept the light ion beams from the existing k=200, multi-stage cyclotron facility, requires an electron beam variable in energy from about 7 to 275 keV. The electron beam system consists of a high perveance electron gun with Pierce geometry and a flat cathode. The gun and a 28 element accelerating column are immersed in a uniform longitudinal magnetic guide field. A computer modeling study of the system was conducted to determine electron beam density and transverse temperature variations as a function of anode region and accelerator column design parameters. Transverse electron beam temperatures (E /SUB t/ = mc 2 β 2 γ(/theta/ /SUB H/ +/theta/ /SUB v/ )) of less than a few tenths of an electron volt at a maximum current density of 0.4 A/cm 2 are desired over the full energy range. This was achieved in the calculations without the use of resonant focusing for a 2 Amp, 275 keV electron beam. Some systematics of the electron beam temperature variations with system design parameters are presented. A short discussion of the mechanical design of the proposed electron beam system is also given

Study of progressive depigmentation of dog′s muzzle

OpenAIRE

Shah K

1991-01-01

A new animal model is developed using dog′s muzzle to demonstrate progressive depigmen-tation after birth. Dog′s muzzle is heavily pigmented with pigment melanin and looks black in colour. Progressive depigmentation was observed two months after birth in a pup born with a depigmented mucous membrane of the mouth and lips. This resembles the vitiligo of humans.

Recent progress on laser acceleration research

International Nuclear Information System (INIS)

Nakajima, Kazuhisa; Dewa, Hideki; Hosokai, Tomonao; Kanazawa, Shuhei; Kando, Masaki; Kondoh, Shuji; Kotaki, Hideyuki

2000-01-01

Recently there has been a tremendous experimental progress in ultrahigh field particle acceleration driven by ultraintense laser pulses in plasmas. A design of the laser wakefield accelerators aiming at GeV energy gains is discussed by presenting our recent progress on the laser wakefield acceleration experiments, the developments of high quality electron beam injectors and the capillary plasma waveguide for optical guiding of ultrashort intense laser pulses. (author)

Designing satisfaction studies

DEFF Research Database (Denmark)

Kristensen, Kai; Eskildsen, Jacob Kjær

2007-01-01

In the effect sampling method, presentation of researcher, the intro text, the order of questions in the questionnaire along with the number of categories in the rating scale is tested in relation to the design of satisfaction studies. Based on the analyses specific recommendations for designing...... satisfaction studies are given....

Nonlinear Progressive Collapse Analysis Including Distributed Plasticity

Directory of Open Access Journals (Sweden)

Mohamed Osama Ahmed

2016-01-01

Full Text Available This paper demonstrates the effect of incorporating distributed plasticity in nonlinear analytical models used to assess the potential for progressive collapse of steel framed regular building structures. Emphasis on this paper is on the deformation response under the notionally removed column, in a typical Alternate Path (AP method. The AP method employed in this paper is based on the provisions of the Unified Facilities Criteria – Design of Buildings to Resist Progressive Collapse, developed and updated by the U.S. Department of Defense [1]. The AP method is often used for to assess the potential for progressive collapse of building structures that fall under Occupancy Category III or IV. A case study steel building is used to examine the effect of incorporating distributed plasticity, where moment frames were used on perimeter as well as the interior of the three dimensional structural system. It is concluded that the use of moment resisting frames within the structural system will enhance resistance to progressive collapse through ductile deformation response and that it is conserative to ignore the effects of distributed plasticity in determining peak displacement response under the notionally removed column.

Visual Design Principles: An Empirical Study of Design Lore

Science.gov (United States)

Kimball, Miles A.

2013-01-01

Many books, designers, and design educators talk about visual design principles such as balance, contrast, and alignment, but with little consistency. This study uses empirical methods to explore the lore surrounding design principles. The study took the form of two stages: a quantitative literature review to determine what design principles are…

Quantitative Reasoning in Environmental Science: A Learning Progression

Science.gov (United States)

Mayes, Robert Lee; Forrester, Jennifer Harris; Christus, Jennifer Schuttlefield; Peterson, Franziska Isabel; Bonilla, Rachel; Yestness, Nissa

2014-01-01

The ability of middle and high school students to reason quantitatively within the context of environmental science was investigated. A quantitative reasoning (QR) learning progression was created with three progress variables: quantification act, quantitative interpretation, and quantitative modeling. An iterative research design was used as it…

Symphony: A case study for exploring and describing design methods and guidelines for learner-centered design

Science.gov (United States)

Quintana, Christopher

Learner-centered design is an evolving software design perspective addressing the needs of learners---a specific audience trying to work in and understand new work practices in which they have a novice or naive understanding. Learner-centered design involves designing software that incorporates work support features (or scaffolding features) informed by social constructivist learning theories. By adopting a constructivist "learning by doing" perspective, scaffolds should support learners so they can mindfully engage in previously inaccessible work activity, which in turn allows those learners to progressively gain a better understanding of the new work. While there is an intuitive notion of "learner-centered design", there is less specific design information for developing learner-centered software. As a result, learner-centered software results from "educated guesses" and ad-hoc design approaches rather than from systematic design methods. Thus there is a need for specific design guidance to facilitate the development of learner-centered tools that help learners see the tasks, terminology, tools, etc. in the new work context and engage in that work. The research in this dissertation provides a more specific base of learner-centered design descriptions, methods, and guidelines to analyze work practices and design and evaluate scaffolds. The research approach involves using the development of Symphony---a scaffolded integrated tool environment for high-school students learning the work of computational science inquiry---as a case study to develop the learner-centered design approach. Symphony incorporates a variety of science tools with process scaffolding to support students in performing complex air pollution investigations. Six ninth-grade students used Symphony to investigate air quality questions for several weeks in an environmental science class. The student testing helped assess the effectiveness of the software scaffolding and in turn, the learner

Study of progressive depigmentation of dog′s muzzle

Directory of Open Access Journals (Sweden)

Shah K

1991-01-01

Full Text Available A new animal model is developed using dog′s muzzle to demonstrate progressive depigmen-tation after birth. Dog′s muzzle is heavily pigmented with pigment melanin and looks black in colour. Progressive depigmentation was observed two months after birth in a pup born with a depigmented mucous membrane of the mouth and lips. This resembles the vitiligo of humans.

Design of steel energy-absorbing restrainers and their incorporation into nuclear power plants for enhanced safety. Progress report

International Nuclear Information System (INIS)

1980-03-01

This program for the development of steel energy-absorbing restrainers originated as a five year multi-institutional, interdisciplinary program. The resources of the University of California, Berkeley (UCB), the Earthquake Engineering Research Center, Richmond (EERC), Massachusetts Institute of Technology (MIT), and Battelle Pacific Northwestern Laboratories (BPNL) are utilized as well as advisors from industry, the utilities and the US Nuclear Regulatory Commission. The present progress report involves the areas of experimental testing on the shaking table at the EERC, restrainer device design and testing, structural analyses and materials testing

Design and development of a learning progression about stellar structure and evolution

Directory of Open Access Journals (Sweden)

Arturo Colantonio

2018-06-01

Full Text Available [This paper is part of the Focused Collection on Astronomy Education Research.] In this paper we discuss the design and development of a learning progression (LP to describe and interpret students’ understanding about stellar structure and evolution (SSE. The LP is built upon three content dimensions: hydrostatic equilibrium; composition and aggregation state; functioning and evolution. The data to build up the levels of the hypothetical LP (LP1 came from a 45-minute, seven-question interview, with 33 high school students previously taught about the topic. The questions were adapted from an existing multiple-choice instrument. Data were analyzed using Minstrell’s “facets” approach. To assess the validity of LP1, we designed a twelve-hour teaching module featuring paper-and-pencil tasks and practical activities to estimate the stellar structure and evolution parameters. Twenty high school students were interviewed before and after the activities using the same interview protocol. Results informed a revision of LP1 (LP2 and, in parallel, of the module. The revised module included supplementary activities corresponding to changes made to LP1. We then assessed LP2 with 30 high school students through the same interview, submitted before and after the teaching intervention. A final version of the LP (LP3 was then developed drawing on students’ emerging reasoning strategies. This paper contributes to research in science education by providing an example of the iterative development of the instruction required to support the student thinking that LPs’ levels describe. Concerning astronomy education research, our findings can inform suitable instructional activities more responsive to students’ reasoning strategies about stellar structure and evolution.

Fundamental studies of separation processes. Technical progress report

International Nuclear Information System (INIS)

Rogers, L.B.

1975-06-01

Studies using high-precision gas chromatography and supercritical fluid chromatography have produced new types of information on liquid crystals and on behavior of substances in the region of the critical temperature, respectively. In addition, the first successful studies of the effects of pressure on cation exchange have been made using aqueous solutions of alkali metal nitrates. In contrast, progress on separations of isotopic species using gas chromatography has been disappointing. In that area, the chief accomplishment has been a determination of the levels of accuracy and precision with which isotopic abundances can be measured using our quadrupole mass spectrometer. (U.S.)

Academic and social integration and study progress in problem based learning

NARCIS (Netherlands)

S.E. Severiens (Sabine); H.G. Schmidt (Henk)

2009-01-01

textabstractThe present study explores the effects of problem-based learning (PBL) on social and academic integration and study progress. Three hundred and five first-year students from three different psychology curricula completed a questionnaire on social and academic integration. Effects of a

The design of modern gas turbine design : beyond CFD

International Nuclear Information System (INIS)

Kenny, D.P.

1998-01-01

The progress that has been made in recent years of applying computational fluid dynamics (CFD) to the design of advanced turbine engines was discussed. Pratt and Whitney has successfully transitioned the design of the company's advanced turbine engines from a five-year design cycle based on a succession of design-test-redesign cycles to a three-year design cycle based on an analytical design methodology. The development of 3-D viscous CFD and computational structural mechanics (CSM) codes as primary design tools and a multi-disciplinary approach to applications have been major factors in achieving this success. The company also made significant progress in the development of a fully implicit unsteady stage scheme, with marked impact on performance and durability. Improvements also have been made in the life of the hot end components and in aero-acoustics. 9 figs

Nuclear waste management. Semiannual progress report, October 1982-March 1983

International Nuclear Information System (INIS)

Chikalla, T.D.; Powell, J.A.

1983-06-01

This document is one of a series of technical progress reports designed to report radioactive waste management programs at the Pacific Northwest Laboratory. Accomplishments in the following programs are reported: waste stabilization; Materials Characterization Center; waste isolation; low-level waste management; remedial action; and supporting studies

Glaucoma Monitoring in a Clinical Setting Glaucoma Progression Analysis vs Nonparametric Progression Analysis in the Groningen Longitudinal Glaucoma Study

NARCIS (Netherlands)

Wesselink, Christiaan; Heeg, Govert P.; Jansonius, Nomdo M.

Objective: To compare prospectively 2 perimetric progression detection algorithms for glaucoma, the Early Manifest Glaucoma Trial algorithm (glaucoma progression analysis [GPA]) and a nonparametric algorithm applied to the mean deviation (MD) (nonparametric progression analysis [NPA]). Methods:

Theoretical reversed field pinch studies: Progress report, August 31, 1987 to June 1988

International Nuclear Information System (INIS)

1988-01-01

This paper describes the progress made in Grant DE-FG02-85ER53212 since the end of the last year, August 31, 1987 to the present (June, 1988). Substantial results have emerged in two areas of high importance to the RFP program - nonlinear evolution with nonideal boundaries and self-consistent equilibrium in the presence of field errors. Both of these topics are critical for a basic understanding of RFP physics, for interpretation of current experiments, and for design of future devices and reactors. 3 refs

Progress of MICE RFCC Module

Energy Technology Data Exchange (ETDEWEB)

Li, D.; Bowring, D.; DeMello, A.; Gourlay, S.; Green, M.; Li, N.; Niinikoski, T.; Pan, H.; Prestemon, S.; Virostek, S.; Zisman, M.; Bross, A.; Carcagno, R.; Kashikhin, V.; Sylvester, C.; Chen, A. B.; Guo, Bin; Li, Liyi; Xu, Fengyu; Cao, Y.; Sun, S.; Wang, Li; Yin, Lixin; Luo, Tianhuan; Summers, Don; Smith, B.; Radovinsky, A.; Zhukovsky, A.; Kaplan, D.

2012-05-20

Recent progress on the design and fabrication of the RFCC (RF and superconducting Coupling Coil) module for the international MICE (Muon Ionization Cooling Experiment) are reported. The MICE ionization cooling channel has two RFCC modules, each having four 201- MHz normal conducting RF cavities surrounded by one superconducting coupling coil (solenoid) magnet. The magnet is designed to be cooled by three cryocoolers. Fabrication of the RF cavities is complete; preparation for the cavity electro-polishing, low power RF measurements, and tuning are in progress at Lawrence Berkeley National Laboratory (LBNL). Fabrication of the cold mass of the first coupling coil magnet has been completed in China and the cold mass arrived at LBNL in late 2011. Preparations for testing the cold mass are currently under way at Fermilab. Plans for the RFCC module assembly and integration are being developed and are described.

Nuclear powered satellite studies. Annual progress report, July 1, 1976--June 30, 1977

International Nuclear Information System (INIS)

Kaplan, M.H.

1977-06-01

Progress achieved during the period July 1, 1976 to June 30, 1977 is reported. Discussions of several pertinent aspects are included, e.g., schedule, personnel, technology developments, and plans. The reporting period is the first year of activities of a project which is designed to provide continuing support to the Nuclear Research and Applications Division of ERDA. Thus, a significant effort has been made to establish appropriate staff positions and liaison ties with government and industry. Technology developments were achieved and communicated to the scientific community via publications and presentations. Project personnel also participated in design reviews and provided support to ERDA on a real-time basis. The report is intended to summarize activities over the past year and provides a basis for continued project support by ERDA

Nuclear powered satellite studies. Annual progress report, July 1, 1978-June 30, 1979

International Nuclear Information System (INIS)

Kaplan, M.H.

1979-06-01

Progress achieved during the period July 1, 1978 to June 30, 1979, on US DOE contract No. EY-76-S-02-4045.A002 is reported. Discussions of several pertinent aspects are included, e.g., schedule, personnel, technology developments, and plans. The reporting period represents the third year of activities of a project which is designed to provide continuing support in the area of nuclear space power technology. Important results have been obtained and communicated to the scientific community via publications and presentations. Project personnel have participated in point design efforts, a NASA Space Power Committee, and periodically provide support to Department of Energy activities as the need arises. The report is intended to summarize activities over the past year and provide a basis for continued project support by US DOE

Static Progressive Orthoses for Elbow Contracture: A Systematic Review

Directory of Open Access Journals (Sweden)

Bin Chen

2017-01-01

Full Text Available Background. As one of the most common musculoskeletal complications following trauma, elbow contracture is a frequent source of disabled daily activities. Conventional interventions are inadequate to provide favorable outcome. The static progressive orthoses are getting popular in the treatment of this problem. Objective. The purpose of this review was to assess the effectiveness of static progressive orthoses for elbow contracture. Methods. Literatures when written in English published during 1 January 1997 and 31 January 2017 were searched in the following databases: Web of Science, Cochrane Library, PubMed, and EBSCOhost. Articles are quality-assessed by two assessors, each article was summarized in evidence tables, and a narrative synthesis was also performed. Results. Ten clinical trials were included. The study design and outcome measures used varied. Significant immediate improvement in the range of motion was reported by all studies, and those effects were still significant at follow-up. No significant difference was shown between static progressive and dynamic orthoses for elbow contracture in one randomized control trial. Conclusions. Current low-quality evidence suggested that static progressive orthoses provided assistance for elbow contracture through improving range of motion. Further research is recommended using high-quality randomized controlled trials.

Progress report on fast breeder reactor development in Japan, July - September 1977

International Nuclear Information System (INIS)

1978-06-01

As for the experimental fast breeder reactor ''Joyo'', the low power performance tests have been continued, and the measurements of reactor noise, the reactivity of fuel assemblies, power distribution and Na-void effect have been made. Efforts have been exerted to develop the required maintenance equipments, to manufacture the transfer rotor maintenance facilities, and to construct the spent fuel storing and cooling facilities. The analysis and calculation of the core characteristics have been in progress. The design work on the prototype fast breeder reactor ''Monju'' has been continued, and the development of the computer codes for the design has progressed. Informations have been gathered regarding the technological developments of LMFBRs overseas. The surveys on the site for ''Monju'' have been carried out. The design and research works on the demonstration reactor were started, and the general design factors such as the steam condition and the plant layout have been studied. As for the research and development of reactor physics, structural components, instrumentation and control, sodium technology, fuel materials, structural materials, safety, and steam generators, the progresses are reported in detail. High performance neutron detectors for nuclear instrumentation have been under development, and the tagging gas method for fuel failure detection and location system has been tested. (Kako, I.)

Progress in FMIT test assembly development

International Nuclear Information System (INIS)

Opperman, E.K.; Vogel, M.A.; Shen, E.J.; Trego, A.L.

1983-08-01

Research and development supporting the completed design of the Fusion Materials Irradiation Test (FMIT) Facility is continuing at the Hanford Engineering Development Laboratory (HEDL) in Richland, Washington. The FMIT, a deuteron accelerator based (d + Li) neutron source, will produce an intense flux of high energy neutrons for use in radiation damage studies of fusion reactor materials. The most intense flux magnitude of greater than 10 15 n/cm 2 -s is located close to the neutron producing lithium target and is distributed within a volume about the size of an American football. The conceptual design and development of FMIT experiments called Test Assemblies has progressed over the past five years in parallel with the design of the FMIT. The paper will describe the recent accomplishments made in developing test assemblies appropriate for use in the limited volume close to the FMIT target where high neutron flux and heating rates and the associated spacial gradients significantly impact design considerations

Progressive apraxia of speech as a window into the study of speech planning processes.

Science.gov (United States)

Laganaro, Marina; Croisier, Michèle; Bagou, Odile; Assal, Frédéric

2012-09-01

We present a 3-year follow-up study of a patient with progressive apraxia of speech (PAoS), aimed at investigating whether the theoretical organization of phonetic encoding is reflected in the progressive disruption of speech. As decreased speech rate was the most striking pattern of disruption during the first 2 years, durational analyses were carried out longitudinally on syllables excised from spontaneous, repetition and reading speech samples. The crucial result of the present study is the demonstration of an effect of syllable frequency on duration: the progressive disruption of articulation rate did not affect all syllables in the same way, but followed a gradient that was function of the frequency of use of syllable-sized motor programs. The combination of data from this case of PAoS with previous psycholinguistic and neurolinguistic data, points to a frequency organization of syllable-sized speech-motor plans. In this study we also illustrate how studying PAoS can be exploited in theoretical and clinical investigations of phonetic encoding as it represents a unique opportunity to investigate speech while it progressively disrupts. Copyright © 2011 Elsevier Srl. All rights reserved.

Geometric and electromyographic assessments in the evaluation of curve progression in idiopathic scoliosis

NARCIS (Netherlands)

Cheung, J; Veldhuizen, AG; Halberts, JPK; Sluiter, WJ; Van Horn, [No Value

2006-01-01

Study Design. The natural history of patients with idiopathic scoliosis was analyzed radiographically and electromyographically in a prospective longitudinal study. Objectives. To identify changes in geometric variables and the sequence in which these changes occur during curve progression in the

Recent progress in gasoline surrogate fuels

KAUST Repository

Sarathy, Mani; Farooq, Aamir; Kalghatgi, Gautam T.

2017-01-01

Petroleum-derived gasoline is currently the most widely used fuel for transportation propulsion. The design and operation of gasoline fuels is governed by specific physical and chemical kinetic fuel properties. These must be thoroughly understood in order to improve sustainable gasoline fuel technologies in the face of economical, technological, and societal challenges. For this reason, surrogate mixtures are formulated to emulate the thermophysical, thermochemical, and chemical kinetic properties of the real fuel, so that fundamental experiments and predictive simulations can be conducted. Early studies on gasoline combustion typically adopted single component or binary mixtures (n-heptane/isooctane) as surrogates. However, the last decade has seen rapid progress in the formulation and utilization of ternary mixtures (n-heptane/isooctane/toluene), as well as multicomponent mixtures that span the entire carbon number range of gasoline fuels (C4–C10). The increased use of oxygenated fuels (ethanol, butanol, MTBE, etc.) as blending components/additives has also motivated studies on their addition to gasoline fuels. This comprehensive review presents the available experimental and chemical kinetic studies which have been performed to better understand the combustion properties of gasoline fuels and their surrogates. Focus is on the development and use of surrogate fuels that emulate real fuel properties governing the design and operation of engines. A detailed analysis is presented for the various classes of compounds used in formulating gasoline surrogate fuels, including n-paraffins, isoparaffins, olefins, naphthenes, and aromatics. Chemical kinetic models for individual molecules and mixtures of molecules to emulate gasoline surrogate fuels are presented. Despite the recent progress in gasoline surrogate fuel combustion research, there are still major gaps remaining; these are critically discussed, as well as their implications on fuel formulation and engine

Recent progress in gasoline surrogate fuels

KAUST Repository

Sarathy, Mani

2017-12-06

Petroleum-derived gasoline is currently the most widely used fuel for transportation propulsion. The design and operation of gasoline fuels is governed by specific physical and chemical kinetic fuel properties. These must be thoroughly understood in order to improve sustainable gasoline fuel technologies in the face of economical, technological, and societal challenges. For this reason, surrogate mixtures are formulated to emulate the thermophysical, thermochemical, and chemical kinetic properties of the real fuel, so that fundamental experiments and predictive simulations can be conducted. Early studies on gasoline combustion typically adopted single component or binary mixtures (n-heptane/isooctane) as surrogates. However, the last decade has seen rapid progress in the formulation and utilization of ternary mixtures (n-heptane/isooctane/toluene), as well as multicomponent mixtures that span the entire carbon number range of gasoline fuels (C4–C10). The increased use of oxygenated fuels (ethanol, butanol, MTBE, etc.) as blending components/additives has also motivated studies on their addition to gasoline fuels. This comprehensive review presents the available experimental and chemical kinetic studies which have been performed to better understand the combustion properties of gasoline fuels and their surrogates. Focus is on the development and use of surrogate fuels that emulate real fuel properties governing the design and operation of engines. A detailed analysis is presented for the various classes of compounds used in formulating gasoline surrogate fuels, including n-paraffins, isoparaffins, olefins, naphthenes, and aromatics. Chemical kinetic models for individual molecules and mixtures of molecules to emulate gasoline surrogate fuels are presented. Despite the recent progress in gasoline surrogate fuel combustion research, there are still major gaps remaining; these are critically discussed, as well as their implications on fuel formulation and engine

Learning Space Service Design

Science.gov (United States)

Felix, Elliot

2011-01-01

Much progress has been made in creating informal learning spaces that incorporate technology and flexibly support a variety of activities. This progress has been principally in designing the right combination of furniture, technology, and space. However, colleges and universities do not design services within learning spaces with nearly the same…

Progress Check Module; Basic Electricity and Electronics Individualized Learning System. Progress Check Booklet.

Science.gov (United States)

Bureau of Naval Personnel, Washington, DC.

The Progress Check Booklet is designed to be used by the student working in the programed course to determine if he has mastered the concepts in the course booklets on: electrical current; voltage; resistance; measuring current and voltage in series circuits; relationships of current, voltage, and resistance; parellel circuits; combination…

A longitudinal study of motor, oculomotor and cognitive function in progressive supranuclear palsy.

Directory of Open Access Journals (Sweden)

Boyd C P Ghosh

Full Text Available We studied the annual change in measures of motor, oculomotor and cognitive function in progressive supranuclear palsy. This had twin objectives, to assess the potential for clinical parameters to monitor disease progression in clinical trials and to illuminate the progression of pathophysiology.Twenty three patients with progressive supranuclear palsy (Richardson's syndrome were compared to 22 matched controls at baseline and 16 of these patients compared at baseline and one year using: the progressive supranuclear palsy rating scale; the unified Parkinson's disease rating scale; the revised Addenbrooke's cognitive examination; the frontal assessment battery; the cubes section of the visual object and space perception battery; the Hayling and Brixton executive tests; and saccadic latencies.Patients were significantly impaired in all domains at baseline. However, cognitive performance was maintained over a year on the majority of tests. The unified Parkinson's disease rating scale, saccadic latency and progressive supranuclear palsy rating scale deteriorated over a year, with the latter showing the largest change. Power estimates indicate that using the progressive supranuclear palsy rating scale as an outcome measure in a clinical trial would require 45 patients per arm, to identify a 50% reduction in rate of decline with 80% power.Motor, oculomotor and cognitive domains deteriorate at different rates in progressive supranuclear palsy. This may be due to differential degeneration of their respective cortical-subcortical circuits, and has major implications for the selection of outcome measures in clinical trials due to wide variation in sensitivity to annual rates of decline.

Educational Design Research: Signs of Progress

Science.gov (United States)

Reeves, Thomas C.

2015-01-01

This special issue of the "Australasian Journal of Educational Technology" includes an introductory article by the guest editors and six papers that illustrate the potential of educational design research (EDR) to address important problems in higher education. In this final paper, reflections on the papers are made. Then the rationale…

Designing HIGH-COST medicine: hospital surveys, health planning, and the paradox of progressive reform.

Science.gov (United States)

Perkins, Barbara Bridgman

2010-02-01

Inspired by social medicine, some progressive US health reforms have paradoxically reinforced a business model of high-cost medical delivery that does not match social needs. In analyzing the financial status of their areas' hospitals, for example, city-wide hospital surveys of the 1910s through 1930s sought to direct capital investments and, in so doing, control competition and markets. The 2 national health planning programs that ran from the mid-1960s to the mid-1980s continued similar strategies of economic organization and management, as did the so-called market reforms that followed. Consequently, these reforms promoted large, extremely specialized, capital-intensive institutions and systems at the expense of less complex (and less costly) primary and chronic care. The current capital crisis may expose the lack of sustainability of such a model and open up new ideas and new ways to build health care designed to meet people's health needs.

MFTF-α + T progress report

International Nuclear Information System (INIS)

Nelson, W.D.

1985-04-01

Early in FY 1983, several upgrades of the Mirror Fusion Test Facility (MFTF-B) at Lawrence Livermore National Laboratory (LLNL) were proposed to the fusion community. The one most favorably received was designated MFTF-α+T. The engineering design of this device, guided by LLNL, has been a principal activity of the Fusion Engineering Design Center during FY 1983. This interim progress report represents a snapshot of the device design, which was begun in FY 1983 and will continue for several years. The report is organized as a complete design description. Because it is an interim report, some parts are incomplete; they will be supplied as the design study proceeds. As described in this report, MFTF-α+T uses existing facilities, many MFTF-B components, and a number of innovations to improve on the physics parameters of MFTF-B. It burns deuterium-tritium and has a central-cell Q of 2, a wall loading GAMMA/sub n/ of 2 MW/m 2 (with a central-cell insert module), and an availability of 10%. The machine is fully shielded, allows hands-on maintenance of components outside the vacuum vessel 24 h after shutdown, and has provisions for repair of all operating components

Serum metabolomics of slow vs. rapid motor progression Parkinson's disease: a pilot study.

Science.gov (United States)

Roede, James R; Uppal, Karan; Park, Youngja; Lee, Kichun; Tran, Vilinh; Walker, Douglas; Strobel, Frederick H; Rhodes, Shannon L; Ritz, Beate; Jones, Dean P

2013-01-01

Progression of Parkinson's disease (PD) is highly variable, indicating that differences between slow and rapid progression forms could provide valuable information for improved early detection and management. Unfortunately, this represents a complex problem due to the heterogeneous nature of humans in regards to demographic characteristics, genetics, diet, environmental exposures and health behaviors. In this pilot study, we employed high resolution mass spectrometry-based metabolic profiling to investigate the metabolic signatures of slow versus rapidly progressing PD present in human serum. Archival serum samples from PD patients obtained within 3 years of disease onset were analyzed via dual chromatography-high resolution mass spectrometry, with data extraction by xMSanalyzer and used to predict rapid or slow motor progression of these patients during follow-up. Statistical analyses, such as false discovery rate analysis and partial least squares discriminant analysis, yielded a list of statistically significant metabolic features and further investigation revealed potential biomarkers. In particular, N8-acetyl spermidine was found to be significantly elevated in the rapid progressors compared to both control subjects and slow progressors. Our exploratory data indicate that a fast motor progression disease phenotype can be distinguished early in disease using high resolution mass spectrometry-based metabolic profiling and that altered polyamine metabolism may be a predictive marker of rapidly progressing PD.

Comparative study of auxetic geometries by means of computer-aided design and engineering

International Nuclear Information System (INIS)

Álvarez Elipe, Juan Carlos; Díaz Lantada, Andrés

2012-01-01

Auxetic materials (or metamaterials) are those with a negative Poisson ratio (NPR) and display the unexpected property of lateral expansion when stretched, as well as an equal and opposing densification when compressed. Such geometries are being progressively employed in the development of novel products, especially in the fields of intelligent expandable actuators, shape morphing structures and minimally invasive implantable devices. Although several auxetic and potentially auxetic geometries have been summarized in previous reviews and research, precise information regarding relevant properties for design tasks is not always provided. In this study we present a comparative study of two-dimensional and three-dimensional auxetic geometries carried out by means of computer-aided design and engineering tools (from now on CAD–CAE). The first part of the study is focused on the development of a CAD library of auxetics. Once the library is developed we simulate the behavior of the different auxetic geometries and elaborate a systematic comparison, considering relevant properties of these geometries, such as Poisson ratio(s), maximum volume or area reductions attainable and equivalent Young’s modulus, hoping it may provide useful information for future designs of devices based on these interesting structures. (paper)

Repository design sensitivity study: Engineering study report

International Nuclear Information System (INIS)

1987-01-01

A preliminary sensitivity study of the salt repository design has been performed to identify critical site and design parameters to help guide future site characterization and design optimization activities. The study considered the SCP-conceptual design at the Deaf Smith County site in Texas with the horizontal waste package emplacement mode as the base case. Relative to this base case, parameter variations were compared. Limited studies were performed which considered the vertical emplacement mode geometry. The report presents the reference data base and design parameters on which the study was based (including the range of parameters that might be expected). Detailed descriptions of the numerical modeling methods and assumptions are included for the thermal, thermomechanical and hydrogeological analyses. The impacts of parameter variations on the sensitivity of the rock mass response are discussed. Recommendations are provided to help guide site characterization activities and advanced conceptual design optimization activities. 47 refs., 119 refs., 22 tabs

Recent progress in high-pressure studies on organic conductors

Directory of Open Access Journals (Sweden)

Syuma Yasuzuka and Keizo Murata

2009-01-01

Full Text Available Recent high-pressure studies of organic conductors and superconductors are reviewed. The discovery of the highest Tc superconductivity among organics under high pressure has triggered the further progress of the high-pressure research. Owing to this finding, various organic conductors with the strong electron correlation were investigated under high pressures. This review includes the pressure techniques using the cubic anvil apparatus, as well as high-pressure studies of the organic conductors up to 10 GPa showing extraordinary temperature and pressure dependent transport phenomena.

ITER-FEAT outline design report

International Nuclear Information System (INIS)

2001-01-01

In July 1998 the ITER Parties were unable, for financial reasons, to proceed with construction of the ITER design proposed at that time, to meet the detailed technical objectives and target cost set in 1992. It was therefore decided to investigate options for the design of ITER with reduced technical objectives and with possibly decreased technical margins, whose target construction cost was one half that of the 1998 ITER design, while maintaining the overall programmatic objective. To identify designs that might meet the revised objectives, task forces involving the JCT and Home Teams met during 1998 and 1999 to analyse and compare a range of options for the design of such a device. This led at the end of 1999 to a single configuration for the ITER design with parameters considered to be the most credible consistent with technical limitations and the financial target, yet meeting fully the objectives with appropriate margins. This new design of ITER, called ''ITER-FEAT'', was submitted to the ITER Director to the ITER Parties as the ''ITER-FEAT Outline Design Report'' (ODR) in January 2000, at their meeting in Tokyo. The Parties subsequently conducted their domestic assessments of this report and fed the resulting comments back into the progressing design. The progress on the developing design was reported to the ITER Technical Advisory Committee (TAC) in June 2000 in the report ''Progress in Resolving Open Design Issues from the ODR'' alongside a report on Progress in Technology R and D for ITER. In addition, the progress in the ITER-FEAT Design and Validating R and D was reported to the ITER Parties. The ITER-FEAT design was subsequently approved by the governing body of ITER in Moscow in June 2000 as the basis for the preparation of the Final Design Report, recognising it as a single mature design for ITER consistent with its revised objectives. This volume contains the documents pertinent to the process described above. More detailed technical information

Progress of full MOX core design in ABWR

International Nuclear Information System (INIS)

Izutsu, S.; Sasagawa, M.; Aoyama, M.; Maruyama, H.; Suzuki, T.

2000-01-01

Full MOX ABWR core design has been made, based on the MOX design concept of 8x8 bundle configuration with a large central water rod, 40 GWd/t maximum bundle exposure, and the compatibility with 9x9 high-burnup UO 2 bundles. Core performance on shutdown margin and thermal margin of the MOX-loaded core is similar to that of UO 2 cores for the range from full UO 2 core to full MOX core. Safety analyses based on its safety parameters and MOX property have shown its conformity to the design criteria in Japan. In order to confirm the applicability of the nuclear design method to full MOX cores, Tank-type Critical Assembly (TCA) experiment data have been analyzed on criticality, power distribution and β eff /l measurements. (author)

Design of the FMIT lithium target

International Nuclear Information System (INIS)

Hassberger, J.A.; Annese, C.E.; Greenwell, R.K.; Ingham, J.G.; Miles, R.R.; Miller, W.C.

1981-01-01

Development of the liquid lithium target for the Fusion Materials Irradiation Test (FMIT) Facility is described. The target concept, major design goals and design requirements are presented. Progress made in the research and development areas leading to detailed design of the target is discussed. This progress, including experimental and analytic results, demonstrates that the FMIT target design is capable of meeting its major design goals and requirements

Non-monotonic reorganization of brain networks with Alzheimer’s disease progression

Directory of Open Access Journals (Sweden)

Hyoungkyu eKim

2015-06-01

Full Text Available Background: Identification of stage-specific changes in brain network of patients with Alzheimer’s disease (AD is critical for rationally designed therapeutics that delays the progression of the disease. However, pathological neural processes and their resulting changes in brain network topology with disease progression are not clearly known. Methods: The current study was designed to investigate the alterations in network topology of resting state fMRI among patients in three different clinical dementia rating (CDR groups (i.e., CDR = 0.5, 1, 2 and amnestic mild cognitive impairment (aMCI and age-matched healthy subject groups. We constructed cost networks from these 5 groups and analyzed their network properties using graph theoretical measures.Results: The topological properties of AD brain networks differed in a non-monotonic, stage-specific manner. Interestingly, local and global efficiency and betweenness of the network were rather higher in the aMCI and AD (CDR 1 groups than those of prior stage groups. The number, location, and structure of rich-clubs changed dynamically as the disease progressed.Conclusions: The alterations in network topology of the brain are quite dynamic with AD progression, and these dynamic changes in network patterns should be considered meticulously for efficient therapeutic interventions of AD.

White Matter Lesion Progression in LADIS

DEFF Research Database (Denmark)

Schmidt, Reinhold; Berghold, Andrea; Jokinen, Hanna

2012-01-01

BACKGROUND AND PURPOSE: White matter lesion (WML) progression has been advocated as a surrogate marker in intervention trials on cerebral small vessel disease. We assessed the rate of visually rated WML progression, studied correlations between lesion progression and cognition, and estimated sample...... sizes for clinical trials with pure WML progression vs combined WML progression-cognitive outcomes. METHODS: Those 394 participants of the Leukoaraiosis and Disability Study (LADIS) study with magnetic resonance imaging scanning at baseline and 3-year follow-up were analyzed. WML progression rating...

Description of load progression and pain response during progressive resistance training early after total hip arthroplasty

DEFF Research Database (Denmark)

Mikkelsen, Lone R; Petersen, Annemette K; Mechlenburg, Inger

2016-01-01

events during the initial four weeks of training. RESULTS: The majority of patients experienced only moderate hip pain during exercise (range in median across exercises and sessions: 5-35 mm Visual Analog Scale) and mild pain at rest (median: 1-18 mm Visual Analog Scale), both of which decreased over...... time ( p training load (67%-166 % across exercises, p training sessions, short term pain response (an increase >20 mm Visual Analog Scale) occurred in 13 patients in 24 training sessions. CONCLUSION: Progressive resistance......OBJECTIVE: To describe a progressive resistance training intervention implemented shortly after total hip arthroplasty, including a detailed description of load progression, pain response and adverse events to the training. DESIGN: Secondary analyses of data from the intervention group...

Learning Space Service Design

Directory of Open Access Journals (Sweden)

Elliot Felix

2011-12-01

Full Text Available Much progress has been made in creating informal learning spaces that incorporate technology and flexibly support a variety of activities. This progress has been principally in designing the right combination of furniture, technology, and space. However, colleges and universities do not design services within learning spaces with nearly the same level of sophistication or integration. Nor do they adequately assess their services. This paper calls for a focus on designing services to facilitate better learning experiences. It describes the fundamentals of service design practice, a selection of exemplary spaces, and the implications for design, budgeting, and staffing.

Performance Evaluation of Moment Connections of Moment Resisting Frames Against Progressive Collapse

Directory of Open Access Journals (Sweden)

M. Mahmoudi

2017-02-01

Full Text Available When a primary structural element fails due to sudden load such as explosion, the building undergoes progressive collapse. The method for design of moment connections during progressive collapse is different to seismic design of moment connections. Because in this case, the axial force on the connections makes it behave differently. The purpose of this paper is to evaluate the performance of a variety of moment connections in preventing progressive collapse in steel moment frames. To achieve this goal, three prequalified moment connections (BSEEP, BFP and WUP-W were designed according seismic codes. These moment connections were analyzed numerically using ABAQUS software for progressive collapse. The results show that the BFP connection (bolted flange plate has capacity much more than other connections because of the use of plates at the junction of beam-column.

Design Study for the Asteroid Redirect Vehicle (ARV) Composite Primary Bulkhead

Science.gov (United States)

Cressman, Thomas O.; Paddock, David A.

2017-01-01

A design study was undertaken of a carbon fiber primary bulkhead for a large solar electric propulsion (SEP) spacecraft. The bulkhead design, supporting up to 16 t of xenon propellant, progressed from one consisting of many simple parts with many complex joints, to one consisting of a few complex parts with a few simple joints. The unique capabilities of composites led to a topology that transitioned loads from bending to in-plane tension and shear, with low part count. This significantly improved bulkhead manufacturability, cost, and mass. The stiffness-driven structure utilized high-modulus M55J fiber unidirectional prepregs. A full-scale engineering demonstration unit (EDU) of the concept was used to demonstrate manufacturability of the concept. Actual labor data was obtained, which could be extrapolated to a full bulkhead. The effort demonstrated the practicality of using high-modulus fiber (HMF) composites for unique shape topologies that minimize mass and cost. The lessons are applicable to primary and secondary aerospace structures that are stiffness driven.

Design and Co-design of Project-organized Studies

DEFF Research Database (Denmark)

Nielsen, Jørgen Lerche; Andreasen, Lars Birch

2014-01-01

The chapter contributes to discussions on design processes in relation to education, presenting different notions of design research and demonstrating how professors and students are involved together in designing innovative and constructive study processes that can help foster students' engagement...

Accelerator research studies. Technical progress report, July 1, 1985-June 30, 1986

International Nuclear Information System (INIS)

1986-01-01

Progress is reported in these areas: study of instabilities and emittance growth in periodic focusing systems for intense beams; study of collective ion acceleration by intense electron beams and pulse powered plasma focus; and study of microwave sources and parameter scaling for high-frequency linacs

Proposal to the United States Energy Research and Development Administration for continuation of fusion reactor technology studies. Progress report October 1, 1977--July 1, 1978

Energy Technology Data Exchange (ETDEWEB)

Conn, R.W.; Kulcinski, G.L.; Maynard, C.W.

1978-01-01

Since the last progress report we have concentrated on three main areas of research: (1) the study of the NUWMAK reactor design, (2) the study of rf heating for tokamak reactors, and (3) the initiation of a tandem mirror reactor study. The initial work on the tandem mirror reactor is included as background in the technical proposal. Summaries of our work on recent assessments of lithium reserves and neutral transport codes are included.

Proposal to the United States Energy Research and Development Administration for continuation of fusion reactor technology studies. Progress report October 1, 1977--July 1, 1978

International Nuclear Information System (INIS)

Conn, R.W.; Kulcinski, G.L.; Maynard, C.W.

1978-01-01

Since the last progress report we have concentrated on three main areas of research: (1) the study of the NUWMAK reactor design, (2) the study of rf heating for tokamak reactors, and (3) the initiation of a tandem mirror reactor study. The initial work on the tandem mirror reactor is included as background in the technical proposal. Summaries of our work on recent assessments of lithium reserves and neutral transport codes are included

Local progression and pseudo progression after single fraction or fractionated stereotactic radiotherapy for large brain metastases. A single centre study

Energy Technology Data Exchange (ETDEWEB)

Wiggenraad, R.; Verbeek-de Kanter, A.; Mast, M. [Radiotherapy Centre West, The Hague (Netherlands); Molenaar, R. [Diaconessenhuis, Leiden (Netherlands). Dept. of Neurology; Lycklama a Nijeholt, G. [Medical Centre Haagladen, The Hague (Netherlands). Dept. of Radiology; Vecht, C. [Medical Centre Haagladen, The Hague (Netherlands). Dept. of Neurology; Struikmans, H. [Radiotherapy Centre West, The Hague (Netherlands); Leiden Univ. Medical Centre (Netherlands). Dept. of Radiotherapy; Kal, H.B.

2012-08-15

Purpose: The 1-year local control rates after single-fraction stereotactic radiotherapy (SRT) for brain metastases > 3 cm diameter are less than 70%, but with fractionated SRT (FSRT) higher local control rates have been reported. The purpose of this study was to compare our treatment results with SRT and FSRT for large brain metastases. Materials and methods: In two consecutive periods, 41 patients with 46 brain metastases received SRT with 1 fraction of 15 Gy, while 51 patients with 65 brain metastases received FSRT with 3 fractions of 8 Gy. We included patients with brain metastases with a planning target volume of > 13 cm{sup 3} or metastases in the brainstem. Results: The minimum follow-up of patients still alive was 22 months. Comparing 1 fraction of 15 Gy with 3 fractions of 8 Gy, the 1-year rates of freedom from any local progression (54% and 61%, p = 0.93) and pseudo progression (85% and 75%, p = 0.25) were not significantly different. Overall survival rates were also not different. Conclusion: The 1-year local progression and pseudo progression rates after 1 fraction of 15 Gy or 3 fractions of 8 Gy for large brain metastases and metastases in the brainstem are similar. For better local control rates, FSRT schemes with a higher biological equivalent dose may be necessary. (orig.)

Local progression and pseudo progression after single fraction or fractionated stereotactic radiotherapy for large brain metastases. A single centre study

International Nuclear Information System (INIS)

Wiggenraad, R.; Verbeek-de Kanter, A.; Mast, M.; Molenaar, R.; Lycklama a Nijeholt, G.; Vecht, C.; Struikmans, H.; Leiden Univ. Medical Centre; Kal, H.B.

2012-01-01

Purpose: The 1-year local control rates after single-fraction stereotactic radiotherapy (SRT) for brain metastases > 3 cm diameter are less than 70%, but with fractionated SRT (FSRT) higher local control rates have been reported. The purpose of this study was to compare our treatment results with SRT and FSRT for large brain metastases. Materials and methods: In two consecutive periods, 41 patients with 46 brain metastases received SRT with 1 fraction of 15 Gy, while 51 patients with 65 brain metastases received FSRT with 3 fractions of 8 Gy. We included patients with brain metastases with a planning target volume of > 13 cm 3 or metastases in the brainstem. Results: The minimum follow-up of patients still alive was 22 months. Comparing 1 fraction of 15 Gy with 3 fractions of 8 Gy, the 1-year rates of freedom from any local progression (54% and 61%, p = 0.93) and pseudo progression (85% and 75%, p = 0.25) were not significantly different. Overall survival rates were also not different. Conclusion: The 1-year local progression and pseudo progression rates after 1 fraction of 15 Gy or 3 fractions of 8 Gy for large brain metastases and metastases in the brainstem are similar. For better local control rates, FSRT schemes with a higher biological equivalent dose may be necessary. (orig.)

Nuclear-waste management semiannual progress report, April 1982-September 1982

International Nuclear Information System (INIS)

Chikalla, T.D.; Powell, J.A.

1982-12-01

This document is one of a series of technical progress reports designed to report on radioactive waste management programs at Pacific Northwest Laboratory. Accomplishments in the following programs are reported: waste treatment; nuclear waste Materials Characterization Center (MCC); airborne waste management; low-level waste management; waste isolation; remedial actions; and supporting studies

White matter lesion progression

DEFF Research Database (Denmark)

Hofer, Edith; Cavalieri, Margherita; Bis, Joshua C

2015-01-01

10 cohorts. To assess the relative contribution of genetic factors to progression of WML, we compared in 7 cohorts risk models including demographics, vascular risk factors plus single-nucleotide polymorphisms that have been shown to be associated cross-sectionally with WML in the current......BACKGROUND AND PURPOSE: White matter lesion (WML) progression on magnetic resonance imaging is related to cognitive decline and stroke, but its determinants besides baseline WML burden are largely unknown. Here, we estimated heritability of WML progression, and sought common genetic variants...... associated with WML progression in elderly participants from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. METHODS: Heritability of WML progression was calculated in the Framingham Heart Study. The genome-wide association study included 7773 elderly participants from...

Inequity in Health Care Financing in Iran: Progressive or Regressive Mechanism?

Science.gov (United States)

Rad, Enayatollah Homaie; Khodaparast, Marzie

2016-06-01

Having progressive health finance mechanism is very important to decrease inequity in health systems. Revenue collection is one of the aspects of health care financing. In this study, taxation system and health insurance contribution of Iranians were assessed. Data of 2012 household expenditures survey were used in this study, and payments of the families for health insurances and tax payments were extracted from the study. Kakwani index was calculated for assessing the progressivity of these payments. At the end, a model was designed to find the effective factors. We found that taxation mechanism was progressive, but insurance contribution mechanism was very regressive. The portion of people living in urban regions was higher in the payments of insurance and tax. Less educated families had lower contribution in health insurance and families with more aging persons paid more for health insurance. Policy makers must pay more attention to the health insurance contribution and change the laws in favour of the poor.

On the Process of Software Design

DEFF Research Database (Denmark)

Hertzum, Morten

2008-01-01

Software design is a complex undertaking. This study delineates and analyses three major constituents of this complexity: the formative element entailed in articulating and reaching closure on a design, the progress imperative entailed in making estimates and tracking status, and the collaboratio...... disintegrate, but the activities required to avoid this may be costly in terms of scarce resources such as the time of key designers...

Serum metabolomics of slow vs. rapid motor progression Parkinson's disease: a pilot study.

Directory of Open Access Journals (Sweden)

James R Roede

Full Text Available Progression of Parkinson's disease (PD is highly variable, indicating that differences between slow and rapid progression forms could provide valuable information for improved early detection and management. Unfortunately, this represents a complex problem due to the heterogeneous nature of humans in regards to demographic characteristics, genetics, diet, environmental exposures and health behaviors. In this pilot study, we employed high resolution mass spectrometry-based metabolic profiling to investigate the metabolic signatures of slow versus rapidly progressing PD present in human serum. Archival serum samples from PD patients obtained within 3 years of disease onset were analyzed via dual chromatography-high resolution mass spectrometry, with data extraction by xMSanalyzer and used to predict rapid or slow motor progression of these patients during follow-up. Statistical analyses, such as false discovery rate analysis and partial least squares discriminant analysis, yielded a list of statistically significant metabolic features and further investigation revealed potential biomarkers. In particular, N8-acetyl spermidine was found to be significantly elevated in the rapid progressors compared to both control subjects and slow progressors. Our exploratory data indicate that a fast motor progression disease phenotype can be distinguished early in disease using high resolution mass spectrometry-based metabolic profiling and that altered polyamine metabolism may be a predictive marker of rapidly progressing PD.

Real-time fMRI neurofeedback: Progress and challenges

Science.gov (United States)

Sulzer, J.; Haller, S.; Scharnowski, F.; Weiskopf, N.; Birbaumer, N.; Blefari, M.L.; Bruehl, A.B.; Cohen, L.G.; deCharms, R.C.; Gassert, R.; Goebel, R.; Herwig, U.; LaConte, S.; Linden, D.; Luft, A.; Seifritz, E.; Sitaram, R.

2016-01-01

In February of 2012, the first international conference on real time functional magnetic resonance imaging (rtfMRI) neurofeedback was held at the Swiss Federal Institute of Technology Zurich (ETHZ), Switzerland. This review summarizes progress in the field, introduces current debates, elucidates open questions, and offers viewpoints derived from the conference. The review offers perspectives on study design, scientific and clinical applications, rtfMRI learning mechanisms and future outlook. PMID:23541800

Progression of disease preceding lower extremity amputation in Denmark

DEFF Research Database (Denmark)

Jensen, Pia Søe; Petersen, Janne; Kirketerp-Møller, Klaus

2017-01-01

OBJECTIVES: Patients with non-traumatic lower extremity amputation are characterised by high age, multi-morbidity and polypharmacy and long-term complications of atherosclerosis and diabetes. To ensure early identification of patients at risk of amputation, we need to gain knowledge about...... the progression of diseases related to lower extremity amputations during the years preceding the amputation. DESIGN: A retrospective population-based national registry study. SETTING: The study includes data on demographics, diagnoses, surgery, medications and healthcare services from five national registries....... Data were retrieved from 14 years before until 1 year after the amputation. Descriptive statistics were used to describe the progression of diseases and use of medication and healthcare services. PARTICIPANTS: An unselected cohort of patients (≥50 years; n=2883) subjected to a primary non...

Myopia Control with Orthokeratology Contact Lenses in Spain (MCOS: Study Design and General Baseline Characteristics

Directory of Open Access Journals (Sweden)

Jacinto Santodomingo-Rubido

2009-01-01

Conclusion: To the authors’ knowledge, MCOS is the first prospective clinical trial to assess the safety and efficacy of orthokeratology contact lens wear to slow myopia progression vs. single-vision spectacle wear. The MCOS offers a number of notable features: prospective design; well-matched samples and high-resolution ocular biometry measures, which should collectively elucidate whether orthokeratology contact lens wear is a feasible and safe method for myopia-progression control.

The effect of conditional probability of chord progression on brain response: an MEG study.

Directory of Open Access Journals (Sweden)

Seung-Goo Kim

Full Text Available BACKGROUND: Recent electrophysiological and neuroimaging studies have explored how and where musical syntax in Western music is processed in the human brain. An inappropriate chord progression elicits an event-related potential (ERP component called an early right anterior negativity (ERAN or simply an early anterior negativity (EAN in an early stage of processing the musical syntax. Though the possible underlying mechanism of the EAN is assumed to be probabilistic learning, the effect of the probability of chord progressions on the EAN response has not been previously explored explicitly. METHODOLOGY/PRINCIPAL FINDINGS: In the present study, the empirical conditional probabilities in a Western music corpus were employed as an approximation of the frequencies in previous exposure of participants. Three types of chord progression were presented to musicians and non-musicians in order to examine the correlation between the probability of chord progression and the neuromagnetic response using magnetoencephalography (MEG. Chord progressions were found to elicit early responses in a negatively correlating fashion with the conditional probability. Observed EANm (as a magnetic counterpart of the EAN component responses were consistent with the previously reported EAN responses in terms of latency and location. The effect of conditional probability interacted with the effect of musical training. In addition, the neural response also correlated with the behavioral measures in the non-musicians. CONCLUSIONS/SIGNIFICANCE: Our study is the first to reveal the correlation between the probability of chord progression and the corresponding neuromagnetic response. The current results suggest that the physiological response is a reflection of the probabilistic representations of the musical syntax. Moreover, the results indicate that the probabilistic representation is related to the musical training as well as the sensitivity of an individual.

Progress on resolution of major surety issues

International Nuclear Information System (INIS)

Bell, C.R.; Boudreau, J.M.

1985-01-01

This paper presents a summary of the major surety issues (safety, environmental protection, sageguards, reliability, quality assurance) that have been identified during Phase I of the SP-100 Program and the progress that has been made in analyzing the most important of these issues in the context of the conceptual design effort. These issues have been identified as inadvertent criticality, toxic material release and dispersion, radiation exposure following end-of-life reentry, potential diversion of special nuclear material, failure to achieve end-of-life neutronic shutdown, and structural predictability for end-of-life re-entry or boost. Because of the complexity of these issues, a simplified conservative approach was taken during Phase I. Progress on these issues has been mainly in the area of increased understanding of the issues, identification of design features to resolve the issues, and quantitative evaluations of the surety characteristics of the various design concepts

Recent progress in conceptual design of LMFR in China

International Nuclear Information System (INIS)

Xu Mi; Ma Dayuan; Chen Yishao

1996-01-01

The Chinese Experimental Fast Reactor (CEFR-25) with the thermal power 65MW and electric power 25MW is the first step of the FBR development in China. The aims of this project are as following: As a prototype to accumulate the experiences of design, construction and operation of a fast reactor; as an irradiation facility to develop fuels and materials with high breeding properties and burn up rate; and as a test reactor core, envisaged, to test the fast reactor core with the fuel Ac-contained. After three years preparation for the CEFR design including the development, collection and reviewing of about 50 computer codes and the decision of the main technical selections and of design boundary conditions, from 1990 to July 1992, the conceptual design of the CEFR-25 has been completed. The confirmation and some optimization of the conceptual design have been carried out from October 1992 to the end of 1993. Based on the conceptual design and related optimization, the main features and characteristics of the CEFR-25 has been given in this paper. Spent almost whole year 1994 for the input preparation the CEFR-25 technical design has been started in the early of the year 1995. The input for the technical design mainly includes: design criteria; input parameters; technical selections confirmed in conceptual design; design requirements, etc., which are briefly described in this paper. For the design requirements to the CEFR-25, of the most important is that the reactor should have passive safety properties, in other words, during any credible transient incident, for instance, ULOF-ULOHS and UTOP, etc., by the negative feedback of reactivity the reactor will enter into and be keeping at safety condition without needs of any personal interference. The residual heat will be removed away by natural convection and natural circulation. Finally, the paper gives the general descriptions about the research and development status for this reactor. (author). 5 figs, 4 tabs

Improving the analysis of designed studies by combining statistical modelling with study design information

NARCIS (Netherlands)

Thissen, U.; Wopereis, S.; Berg, S.A.A. van den; Bobeldijk, I.; Kleemann, R.; Kooistra, T.; Dijk, K.W. van; Ommen, B. van; Smilde, A.K.

2009-01-01

Background: In the fields of life sciences, so-called designed studies are used for studying complex biological systems. The data derived from these studies comply with a study design aimed at generating relevant information while diminishing unwanted variation (noise). Knowledge about the study

Pion correlations and calorimeter design for high energy heavy ion collisions. Progress report

International Nuclear Information System (INIS)

Wolf, K.L.

1997-01-01

Data analysis is in progress for recent experiments performed by the NA44 collaboration with the first running of 160 A GeV 208 Pb-induced reactions at the CERN SPS. Identified singles spectra were taken for pions, kaons, protons, deuterons, antiprotons and antideuterons. Two-pion interferometry measurements were made for semi-central-triggered 208 Pb + Pb collisions. An updated multi-particle spectrometer allows high statistics data sets of identified particles to be collected near mid-rapidity. A second series of experiments will be performed in the fall of 1995 with more emphasis on identical kaon interferometry and on the measurement of rare particle spectra and correlations. Modest instrumentation upgrades by TAMU are designed to increase the trigger function for better impact parameter selection and improved collection efficiency of valid events. An effort to achieve the highest degree of projectile-target stopping is outlined and it is argued that an excitation function on the SPS is needed to better understand reaction mechanisms. Analysis of experimental results is in the final stages at LBL in the EOS collaboration for two-pion interferometry in the 1.2 A GeV Au + Au reaction, taken with full event characterization

Successful Career Progression: Exploratory Findings from a Study of Selected Occupations.

Science.gov (United States)

O'Shea, Daniel P.; Betsinger, Alicia M.; King, Christopher T.

A study examined the career progression of individuals in the following occupations: registered nurse; physical therapist; medical laboratory technologist; paramedic; ranked corrections officer; dental hygienist; electronic technician; pipefitter/plumber; social worker; and auto body shop manager. Researchers conducted face-to-face interviews in…

Stable isotope studies. Progress report, August 1, 1974--July 31, 1975

International Nuclear Information System (INIS)

Flynn, G.W.; Hsu, D.S.Y.; Preses, J.M.; Spindel, W.; Weston, R.E.

1975-01-01

Progress is reported in the following studies: selective two-step laser-induced photodissociation, unimolecular processes induced by multiple-photon absorption, and vibrational energy transfer processes involving isotopic species of sulfur dioxide. These laser-induced chemical reactions can possibly be applied to isotope separation

Nuclear spectroscopic studies. Progress report

International Nuclear Information System (INIS)

Bingham, C.R.; Riedinger, L.L.; Sorensen, S.P.

1996-01-01

This report describes progress in the experimental nuclear physics program of the University of Tennessee, Knoxville. It presents findings related to properties of high-spin states, low-energy levels of nuclei far from stability, and high-energy heavy-ion physics, as well as a brief description of the Joint Institute of Heavy Ion Research (a collaboration between the University of Tennessee, Vanderbilt University, and Oak Ridge National Laboratory) and its activities (particularly those of the last few years), and a list of publications. 89 refs., 18 figs., 5 tabs

Accelerator research studies: Technical progress report, June 1, 1988--May 31, 1989

International Nuclear Information System (INIS)

1989-01-01

This report discusses research progress in the following general topics: Study of transport and longitudinal compression of intense, high-brightness beams; study of collective ion acceleration by intense electron beams and pulse powered plasma focus; and study of microwave sources and parameter scaling for high-frequency electron-positron supercollider linacs

Incidence and progression of aortic valve calcium in the Multi-ethnic Study of Atherosclerosis (MESA).

Science.gov (United States)

Owens, David S; Katz, Ronit; Takasu, Junichiro; Kronmal, Richard; Budoff, Matthew J; O'Brien, Kevin D

2010-03-01

Aortic valve calcium (AVC) is common among older adults and shares epidemiologic and histopathologic similarities to atherosclerosis. However, prospective studies have failed to identify meaningful risk associations with incident ("new") AVC or its progression. In the present study, AVC was quantified from serial computed tomographic images from 5,880 participants (aged 45 to 84 years) in the Multi-Ethnic Study of Atherosclerosis, using the Agatston method. Multivariate backward selection modeling was used to identify the risk factors for incident AVC and AVC progression. During a mean follow-up of 2.4 +/- 0.9 years, 210 subjects (4.1%) developed incident AVC. The incidence rate (mean 1.7%/year) increased significantly with age (p AVC included age, male gender, body mass index, current smoking, and the use of lipid-lowering and antihypertensive medications. Among those with AVC at baseline, the median rate of AVC progression was 2 Agatston units/year (interquartile range -21 to 37). The baseline Agatston score was a strong, independent predictor of progression, especially among those with high calcium scores at baseline. In conclusion, in this ethnically diverse, preclinical cohort, the rate of incident AVC increased significantly with age. The incident AVC risk was associated with several traditional cardiovascular risk factors, specifically age, male gender, body mass index, current smoking, and the use of both antihypertensive and lipid-lowering medications. AVC progression risk was associated with male gender and the baseline Agatston score. Additional research is needed to determine whether age- and stage-specific mechanisms underlie the risk of AVC progression. Copyright 2010 Elsevier Inc. All rights reserved.

FY13 Annual Progress Report for SECA Core Technology Program

Energy Technology Data Exchange (ETDEWEB)

Stevenson, Jeffry W. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Koeppel, Brian J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

2014-01-31

This progress report covers technical work performed during fiscal year 2013 at PNNL under Field Work Proposal (FWP) 40552. The report highlights and documents technical progress in tasks related to advanced cell and stack component materials development and computational design and simulation.

131I albumin of patients carrying progressive systemic sclerosis study

International Nuclear Information System (INIS)

Cossermelli, W.; Carvalho, N.; Papaleo Netto, M.

1974-01-01

131 I albumin metabolic changes were studied in 14 female patients with progressive systemic sclerosis. A statistical study of the gathered data disclosed increased distribution and turnover half-life and diminished turnover rate of radioactive substance. Since T/2 of turnover and turnover rate are the result produced by the albumin synthesis and degradation, they are probably lowered during active disease causing hypoalbuminemia. The aminoacids also are probably absorbed by other protein like the gammaglobuline synthesis [pt

The Association of Statin Use with Age-Related Macular Degeneration Progression The Age-Related Eye Disease Study 2 Report Number 9

Science.gov (United States)

Al-Holou, Shaza N.; Tucker, William R.; Agrón, Elvira; Clemons, Traci E.; Cukras, Catherine; Ferris, Frederick L.; Chew, Emily Y.

2015-01-01

Objective/purpose To evaluate the association of statin use with progression of age-related macular degeneration (AMD). Design Preplanned, prospective cohort study within a controlled clinical trial of oral supplementation for age-related eye diseases. Subjects Age-Related Eye Disease Study 2 participants, aged 50 to 85 years. Methods Factors, including age, gender, smoking status, aspirin use, and history of diabetes, hypertension, heart disease, angina, and stroke, all known to be associated with statin use, were included in a logistic regression model to estimate propensity scores for each participant. Age-adjusted proportional hazards regression models, with and without propensity score matching, were performed to evaluate the association of statin use with progression to late AMD. Analyses were also performed adjusting for the competing risk of death. Main Outcome Measures Baseline and annual stereoscopic fundus photographs were assessed centrally by masked graders for the development of late AMD, either neovascular AMD or geographic atrophy (GA). Results Of the 3791 participants (2462 with bilateral large drusen and 1329 with unilateral late AMD at baseline), 1659 (43.8%) were statin users. The overall analysis, with no matching of propensity scores and no adjustment for death as a competing risk, showed that statin use was not associated with progression to late AMD (hazard ratios [HR] of 1.08, 95% confidence intervals [CI] of 0.83–1.41, P=0.56). When matched for propensity scores and adjusted for death as a competing risk, the result was not statistically significant with HR: 0.81, 95% CI: 0.55–1.20, P=0.29. Further subgroup analyses of persons with or without late AMD at baseline to the various components of late AMD (neovascular, central geographic atrophy, or any geographic atrophy) also showed no statistically significant association of statin use with progression to AMD. Conclusions Statin use was not statistically significantly associated with the

Molecular design of flotation collectors: A recent progress.

Science.gov (United States)

Liu, Guangyi; Yang, Xianglin; Zhong, Hong

2017-08-01

The nature of froth flotation is to selectively hydrophobize valuable minerals by collector adsorption so that the hydrophobized mineral particles can attach air bubbles. In recent years, the increasing commercial production of refractory complex ores has been urgent to develop special collectors for enhancing flotation separation efficiency of valuable minerals from these ores. Molecular design methods offer an effective way for understanding the structure-property relationship of flotation collectors and developing new ones. The conditional stability constant (CSC), molecular mechanics (MM), quantitative structure-activity relationship (QSAR), and first-principle theory, especially density functional theory (DFT), have been adopted to build the criteria for designing flotation collectors. Azole-thiones, guanidines, acyl thioureas and thionocarbamates, amide-hydroxamates, and double minerophilic-group surfactants such as Gemini, dithiourea and dithionocarbamate molecules have been recently developed as high-performance collectors. To design hydrophobic groups, the hydrophilic-hydrophobic balance parameters have been extensively used as criteria. The replacement of aryl group with aliphatic group or CC single bond(s) with CC double bond(s), reduction of carbon numbers, introduction of oxygen atom(s) and addition of trisiloxane to the tail terminal have been proved to be useful approaches for adjusting the surface activity of collectors. The role of molecular design of collectors in practical flotation applications was also summarized. Based on the critical review, some comments and prospects for further research on molecular design of flotation collectors were also presented in the paper. Copyright © 2017 Elsevier B.V. All rights reserved.

Progress report, Physics Division, July 1 to September 30, 1975

International Nuclear Information System (INIS)

1975-10-01

Progress in the Physics Division, CRNL, for the period July 1 to September 30, 1975 is reported. Operation of the MP tandem accelerator and design studies for a superconducting heavy ion cyclotron are summarized. Research on nuclear reactions and radioisotope decay is reported. Studies of neutron scattering on liquid helium and properties of ferromagnetic alloys are presented. A summary of computing centre operations is also provided. (O.T.)

Study of atmospheric pollution scavenging. Seventeenth progress report

Energy Technology Data Exchange (ETDEWEB)

Semonin, R.G.; Bartlett, J.; Gatz, D.F.; Peden, M.E.; Skowron, L.M.; Stensland, G.J.

1979-07-01

The continued study of historical precipitation chemistry, air quality, and emissions data shows that the nitrate concentrations in precipitation have increased over the past 20 years with little change in sulfate concentrations. An analysis of aerosol concentrations at MAP3S precipitation collection sites shows consistently higher elemental concentrations at urban Champaign, Illinois, than sites at Whiteface Mountain, New York, and rural Champaign. Scavenging ratios at Whiteface exceeded those obtained previously at St. Louis, Missouri, possibly due to mid-tropospheric long-range transport and differing synoptic situations. Factor analysis of 6 storms during METROMEX shows that different deposition patterns were found for the soluble and insoluble concentrations of the same element. This suggests different scavenging processes may be active for these fractions. Using METROMEX data, no correlation was found between pollutant source strength and the urban-related precipitation anomaly. Four different Nuclepore air filter setups were used to compare air concentrations of sulfate, nitrate, and ammonium. The sulfate comparison was good, but the large variability for nitrate and ammonium raise serious questions on the credibility of measurements using Nuclepore as the collection medium. The details of a case study of wet deposition from SCORE-78 are presented and shows the pollutant concentrations are more variable than the rainfall. A brief description of the progress on the SCORE-79 project is presented. The progress on acid rainfall studies shows that the high pH values in the Midwest in the mid-1950's were due in part to elevated concentrations of calcium and magnesium. A variety of model calculations are presented to show the effects of adjusting past data to currently observed values. Recent results of continuing research on ionic stability of precipitation samples are given.

Flexible displays, rigid designs?

DEFF Research Database (Denmark)

Hornbæk, Kasper

2015-01-01

Rapid technological progress has enabled a wide range of flexible displays for computing devices, but the user experience--which we're only beginning to understand--will be the key driver for successful designs.......Rapid technological progress has enabled a wide range of flexible displays for computing devices, but the user experience--which we're only beginning to understand--will be the key driver for successful designs....

BIPS GDS miscellaneous, design notes

International Nuclear Information System (INIS)

1976-01-01

A compendium of miscellaneous documents, memos, and progress report extracts for the Brayton Isotope Power System Ground Demonstration System Preliminary Design Review is presented. The document does not represent a formal interim or final report, but is furnished to aid the customer in evaluating the progress of the ERDA BIPS GDS design

Muon collider design

Energy Technology Data Exchange (ETDEWEB)

Palmer, R.B.; Muon Collider Collaboration

1998-01-01

Parameters are given of machines with center-of-mass (CoM) energies of 3 TeV and 400 GeV but, besides a comment on neutrino radiation, the paper concentrates on progress on the design of a machine to operate at a light Higgs mass, assumed, for this study, to be 100 GeV (CoM).

Memphis State University Center for Nuclear Studies progress report

International Nuclear Information System (INIS)

1975-11-01

Progress made on the development of specialized education programs for the nuclear industry through the month of October, 1975, is outlined. The survey of the nuclear industry includes manpower resources and requirements of nuclear industry, annual training requirements of nuclear plants, and the educational curriculum for nuclear plant operational staff. Also discussed are the general organization of the project, student enrollment and progress and industrial participation

Experimental medium energy physics: Annual progress report June 1987--May 1988

International Nuclear Information System (INIS)

1988-01-01

This report discusses progress in experimental medium energy physics at Carnegie Mellon University. Some of the topics covered are: search for the ξ(2230); hyperon-antihyperon production studies; relativistic proton-nucleus and heavy ion-nucleus collisions; H dibaryon physics; hypernuclear physics research; pion physics; H particle experiment design and development; and electron scattering

Ultrasonic flowmeters. Progress report II

International Nuclear Information System (INIS)

Wittekind, W.D.

1980-01-01

This progress report presents results of in-plant testing of the prototype ultrasonic flowmeter and describes modifications to the prototype as a result of these tests. The modified prototype, designated MOD-I, is described in detail including the principle of operation, equipment used and the results of both laboratory and in-plant demonstrations

Technical meeting on progress in managing, and limiting the consequences of events exceeding the design basis

International Nuclear Information System (INIS)

Fabian, H.

2004-01-01

The Technical Groups on 'Reactor Safety' and 'Thermodynamics and Fluid Dynamics' of the Kerntechnische Gesellschaft e.V. organized a joint technical meeting on 'Progress in Managing, and Limiting the Consequences of, Events Exceeding the Design Basis' at the FTU Training Center of the Karlsruhe Research Center. The topic chosen, the papers presented, the presenters, and the non-technical part of the program met with lively interest on the part of institutions in the nuclear field. These were the objectives of the technical meeting: - Establishing a forum for communicating relevant topics. - In-depth discussion of the main topic, i.e. the advanced development of reactor safety, research in the field, and its application, in twenty selected papers presented by speakers from different institutions. - Presentation of topical work in a nuclear technology institution, the Karlsruhe Research Center. (orig.) [de

MFTF-. cap alpha. + T progress report

Energy Technology Data Exchange (ETDEWEB)

Nelson, W.D. (ed.)

1985-04-01

Early in FY 1983, several upgrades of the Mirror Fusion Test Facility (MFTF-B) at Lawrence Livermore National Laboratory (LLNL) were proposed to the fusion community. The one most favorably received was designated MFTF-..cap alpha..+T. The engineering design of this device, guided by LLNL, has been a principal activity of the Fusion Engineering Design Center during FY 1983. This interim progress report represents a snapshot of the device design, which was begun in FY 1983 and will continue for several years. The report is organized as a complete design description. Because it is an interim report, some parts are incomplete; they will be supplied as the design study proceeds. As described in this report, MFTF-..cap alpha..+T uses existing facilities, many MFTF-B components, and a number of innovations to improve on the physics parameters of MFTF-B. It burns deuterium-tritium and has a central-cell Q of 2, a wall loading GAMMA/sub n/ of 2 MW/m/sup 2/ (with a central-cell insert module), and an availability of 10%. The machine is fully shielded, allows hands-on maintenance of components outside the vacuum vessel 24 h after shutdown, and has provisions for repair of all operating components.

Study of Patterns and Markers of Human Immune Deficiency Virus -1 (HIV-1) Progression and Unemployment Rate among Patients from Alexandria, Egypt.

Science.gov (United States)

Ghoneim, Faika M; Raouf, May M; Elshaer, Noha S; Abdelhamid, Sarah M; Noor Eldeen, Reem A

2017-12-04

Middle East and North Africa (MENA) new HIV cases show the highest increase among all regions in the world. Even though Egypt has a low prevalence among the general population (< 0.02%), a national HIV epidemic occurs in certain population risk groups. The current study was conducted to asses clinical and immunological disease progression; following up viral load (VL) and detecting delta-32 CCR5 genotype polymorphism in selected cases, determining unemployment rate and identify predictors of employment for HIV-cases. A cross sectional design was adopted. HIV infected cases attending Alexandria Fever Hospital (AFH) for one year. Interview questionnaire and four CD+4 counts were done for all patients, HIV VL and delta-32 CCR5 polymorphism were done for selected cases. Sexual transmission and drug abuse are the most important risk factors. Infectious comorbidity increases the rate of HIV progression. CD4+ count at the end of the study; CD+4 (4), count was significantly higher than all other CD4+ readings among the whole cohort and among the treated group. Also, VL at the end of the study; VL(2), was significantly higher than VL(1) among the untreated group. Unemployment rate was 40%. Male gender and obtaining vocational training were significant predictors of employment. It can be concluded that having a family member living with HIV and drug abusers are high risk groups for HIV acquisition. Factors responsible for progression of HIV should be further investigated. Antiretroviral therapy is very effective in checking HIV replication rate, delaying the progression of HIV, reconstituting the immune response and should be available for all cases detected.

Does monitoring goal progress promote goal attainment? A meta-analysis of the experimental evidence.

Science.gov (United States)

Harkin, Benjamin; Webb, Thomas L; Chang, Betty P I; Prestwich, Andrew; Conner, Mark; Kellar, Ian; Benn, Yael; Sheeran, Paschal

2016-02-01

Control theory and other frameworks for understanding self-regulation suggest that monitoring goal progress is a crucial process that intervenes between setting and attaining a goal, and helps to ensure that goals are translated into action. However, the impact of progress monitoring interventions on rates of behavioral performance and goal attainment has yet to be quantified. A systematic literature search identified 138 studies (N = 19,951) that randomly allocated participants to an intervention designed to promote monitoring of goal progress versus a control condition. All studies reported the effects of the treatment on (a) the frequency of progress monitoring and (b) subsequent goal attainment. A random effects model revealed that, on average, interventions were successful at increasing the frequency of monitoring goal progress (d+ = 1.98, 95% CI [1.71, 2.24]) and promoted goal attainment (d+ = 0.40, 95% CI [0.32, 0.48]). Furthermore, changes in the frequency of progress monitoring mediated the effect of the interventions on goal attainment. Moderation tests revealed that progress monitoring had larger effects on goal attainment when the outcomes were reported or made public, and when the information was physically recorded. Taken together, the findings suggest that monitoring goal progress is an effective self-regulation strategy, and that interventions that increase the frequency of progress monitoring are likely to promote behavior change. (c) 2016 APA, all rights reserved).

Field cage studies and progressive evaluation of genetically-engineered mosquitoes.

Directory of Open Access Journals (Sweden)

Luca Facchinelli

Full Text Available A genetically-engineered strain of the dengue mosquito vector Aedes aegypti, designated OX3604C, was evaluated in large outdoor cage trials for its potential to improve dengue prevention efforts by inducing population suppression. OX3604C is engineered with a repressible genetic construct that causes a female-specific flightless phenotype. Wild-type females that mate with homozygous OX3604C males will not produce reproductive female offspring. Weekly introductions of OX3604C males eliminated all three targeted Ae. aegypti populations after 10-20 weeks in a previous laboratory cage experiment. As part of the phased, progressive evaluation of this technology, we carried out an assessment in large outdoor field enclosures in dengue endemic southern Mexico.OX3604C males were introduced weekly into field cages containing stable target populations, initially at 10:1 ratios. Statistically significant target population decreases were detected in 4 of 5 treatment cages after 17 weeks, but none of the treatment populations were eliminated. Mating competitiveness experiments, carried out to explore the discrepancy between lab and field cage results revealed a maximum mating disadvantage of up 59.1% for OX3604C males, which accounted for a significant part of the 97% fitness cost predicted by a mathematical model to be necessary to produce the field cage results.Our results indicate that OX3604C may not be effective in large-scale releases. A strain with the same transgene that is not encumbered by a large mating disadvantage, however, could have improved prospects for dengue prevention. Insights from large outdoor cage experiments may provide an important part of the progressive, stepwise evaluation of genetically-engineered mosquitoes.

A generic approach does not work : Disciplinary differences as explanation for study progress in higher professional education

NARCIS (Netherlands)

Kamphorst, J. C.; Hofman, W. H. A.; Jansen, E. P. W. A.; Terlouw, C.

2012-01-01

A generic approach does not work. Disciplinary differences as explanation for study progress in higher professional education. We combine concepts of Tinto's theory on student departure and Becher's theory on disciplinary tribes for explaining study progress in universities. We collected data with

Progress in IFMIF Engineering Validation and Engineering Design Activities

International Nuclear Information System (INIS)

Heidinger, R.; Knaster, J.; Matsumoto, H.; Sugimoto, M.; Mosnier, A.; Arbeiter, F.; Baluc, N.; Cara, P.; Chel, S.; Facco, A.; Favuzza, P.; Heinzel, V.; Ibarra, A.; Massaut, V.; Micciche, G.; Nitti, F.S.; Theile, J.

2013-01-01

Highlights: ► The IFMIF/EVEDA project has entered into the crucial phase of concluding the Interim IFMIF Engineering Design Report. ► The IFMIF plant configuration has been established with the definition of five IFMIF facilities and of their interfaces. ► Three major prototypes of the IFMIF main systems have been designed and are being manufactured, commissioned and operated. -- Abstract: The International Fusion Materials Irradiation Facility (IFMIF) Engineering Design and Engineering Validation Activities (EVEDA) are being developed in a joint project in the framework of the Broader Approach (BA) Agreement between EU and Japan. This project has now entered into a crucial phase as the engineering design of IFMIF is now being formulated in a series of 3 subsequent phases for delivering an Interim IFMIF Engineering Design Report (IIEDR) by mid of 2013. Content of these phases is explained, including the plant configuration detailing the 5 IFMIF facilities and their systems. Together with the Engineering Design Activities, prototyping sub-projects are pursued in the Engineering Validation Activities which consist of the design, manufacturing and testing of the following prototypical systems: Linear IFMIF Prototype Accelerator (LIPAc), EVEDA Lithium Test Loop (ELTL), and High Flux Test Module (HFTM) with the prototypical helium cooling loop (HELOKA). Highlights are described from recent experiments in the Engineering Validation Activities

Progress with Long-Range Beam-Beam Compensation Studies for High Luminosity LHC

Energy Technology Data Exchange (ETDEWEB)

Rossi, Adriana; et al.

2017-05-01

Long-range beam-beam (LRBB) interactions can be a source of emittance growth and beam losses in the LHC during physics and will become even more relevant with the smaller '* and higher bunch intensities foreseen for the High Luminosity LHC upgrade (HL-LHC), in particular if operated without crab cavities. Both beam losses and emittance growth could be mitigated by compensat-ing the non-linear LRBB kick with a correctly placed current carrying wire. Such a compensation scheme is currently being studied in the LHC through a demonstration test using current-bearing wires embedded into col-limator jaws, installed either side of the high luminosity interaction regions. For HL-LHC two options are considered, a current-bearing wire as for the demonstrator, or electron lenses, as the ideal distance between the particle beam and compensating current may be too small to allow the use of solid materials. This paper reports on the ongoing activities for both options, covering the progress of the wire-in-jaw collimators, the foreseen LRBB experiments at the LHC, and first considerations for the design of the electron lenses to ultimately replace material wires for HL-LHC.

Constitutive behavior and progressive mechanical failure of electrodes in lithium-ion batteries

Science.gov (United States)

Zhang, Chao; Xu, Jun; Cao, Lei; Wu, Zenan; Santhanagopalan, Shriram

2017-07-01

The electrodes of lithium-ion batteries (LIB) are known to be brittle and to fail earlier than the separators during an external crush event. Thus, the understanding of mechanical failure mechanism for LIB electrodes (anode and cathode) is critical for the safety design of LIB cells. In this paper, we present experimental and numerical studies on the constitutive behavior and progression of failure in LIB electrodes. Mechanical tests were designed and conducted to evaluate the constitutive properties of porous electrodes. Constitutive models were developed to describe the stress-strain response of electrodes under uniaxial tensile and compressive loads. The failure criterion and a damage model were introduced to model their unique tensile and compressive failure behavior. The failure mechanism of LIB electrodes was studied using the blunt rod test on dry electrodes, and numerical models were built to simulate progressive failure. The different failure processes were examined and analyzed in detail numerically, and correlated with experimentally observed failure phenomena. The test results and models improve our understanding of failure behavior in LIB electrodes, and provide constructive insights on future development of physics-based safety design tools for battery structures under mechanical abuse.

Environmental Studies Group progress report for 1979

International Nuclear Information System (INIS)

Hunt, D.C.; Hurley, J.D.

1981-01-01

The 1979 progress report gives descriptions, results, and/or status on programs involving (1) physical transport of radionuclides in blowing dust, (2) radionuclide distributions in the sediment of area water bodies, (3) management of open space lands (including a remote sensing program) at Rocky Flats, (4) the ecology and radioecology of terrestrial open space areas in Plant site lands, (5) biological pathways for radionuclide transport, (6) evaluations of environmental monitoring data on radionuclides in air and water, (7) results of a special soil sampling program on lands adjacent to the Plant site, and (8) two special programs - one concerning evaluations of epidemiological studies of health effects purported to be related to the Plant, and a second that specifies information on accumulations of material in process building filter plenums required for evaluation of potential accidents

Building a progressive vertical integration

International Nuclear Information System (INIS)

Charette, D.

2008-01-01

AAER Inc. is a Quebec-based company that manufactures turbines using proven European designs. This presentation discussed the company's business model. The company places an emphasis on identifying strategic and key components currently available for its turbines. Market analyses are performed in order to determine ideal suppliers and define business strategies and needs. The company invests in long-term relationships with its suppliers. Business partners for AAER are of a similar size and have a mutual understanding and respect for the company's business practices. Long-term agreements with suppliers are signed in order to ensure reliability and control over costs. Progressive vertical integration has been achieved by progressively manufacturing key components and integrating a North American supply chain. The company's secure supply chain and progressive vertical integration has significantly reduced financial costs and provided better quality control. It was concluded that vertical integration has also allowed AAER to provide better customer service and reduce transportation costs. tabs., figs

A Study on SE Methodology for Design of Big Data Pilot Platform to Improve Nuclear Power Plant Safety

Energy Technology Data Exchange (ETDEWEB)

Shin, Junguk; Cha, Jae-Min; Kim, Jun-Young; Park, Sung-Ho; Yeom, Choong-Sub [Institute for Advanced Engineering (IAE), Yongin (Korea, Republic of)

2016-10-15

A big data concept is expected to have a large impact on the safety of the nuclear power plant (NPP) from the beginning of the big data era. Though there are high interests on the NPP safety with the big data, almost no studies on the logical and physical structures and the systematic design methods of the big data platform for the NPP safety have been conducted. For the current study, a new big data pilot platform for the NPP safety is designed with the main focus on the health monitoring and early warning systems, and a tailored design process based on the systems engineering approaches is proposed to manage inherent high complexity of the platform design. The big data concept is expected to have a large impact on the safety of the NPP. So, in this study, the big data pilot platform for the health monitoring and early warning of the NPP is designed. For this, the development process based on the SE approach for the pilot platform is proposed and the design results along with the proposed process are also presented. Implementation of the individual modules and integrations of those are in currently progress.

A Study on SE Methodology for Design of Big Data Pilot Platform to Improve Nuclear Power Plant Safety

International Nuclear Information System (INIS)

Shin, Junguk; Cha, Jae-Min; Kim, Jun-Young; Park, Sung-Ho; Yeom, Choong-Sub

2016-01-01

A big data concept is expected to have a large impact on the safety of the nuclear power plant (NPP) from the beginning of the big data era. Though there are high interests on the NPP safety with the big data, almost no studies on the logical and physical structures and the systematic design methods of the big data platform for the NPP safety have been conducted. For the current study, a new big data pilot platform for the NPP safety is designed with the main focus on the health monitoring and early warning systems, and a tailored design process based on the systems engineering approaches is proposed to manage inherent high complexity of the platform design. The big data concept is expected to have a large impact on the safety of the NPP. So, in this study, the big data pilot platform for the health monitoring and early warning of the NPP is designed. For this, the development process based on the SE approach for the pilot platform is proposed and the design results along with the proposed process are also presented. Implementation of the individual modules and integrations of those are in currently progress

Designing and Implementing the Model of Public Assessment of Social and Cultural Progress in Universities

Directory of Open Access Journals (Sweden)

Gholamreza Khaje Sarvi

2013-03-01

Full Text Available Implementing Investigations, analyzes and performance measurements in special and qualitative social/cultural arena in our country, needs local and special methodologies. Thus the aim of present article is investigating these issues: the concept of culture, classification of cultural organizations in Islamic Republic of Iran, the Pyramidal structure of cultural hierarchy, the process of development and mutual influences of institutions, reviewing related literature of policy making in cultural issues, compatibility of strategies to existing realities in cultural performance structure, double division in measures and analyzing and elaborating suggested measures in elaborating weighting model and assessment method and investigating progress measures by focusing on Islamic-Iranian pattern of progress and investigating the effects of implementing this pattern plus weighting method and using related measures and studying some university cases which are implemented in three phases in universities and high education centers overall the country. This research has shown a linear model by considering weighting coefficients.

The 1989 progress report of GANIL: Operations and machine studies

International Nuclear Information System (INIS)

1990-03-01

The 1989 progress report of the GANIL (French acronym for National Large Accelerator of Heavy Ions) is presented. The studies and the operations performed on the accelerator during the 10th July to the 18th December are summarized. The machine's operating time, the time required in the starting step and the time available for the users are examined. Several technical studies performed are reported. The results obtained after the energy increase operation are satisfactory. The beam intensity was increased of about a factor of 10 [fr

LIFE: Recent Developments and Progress

International Nuclear Information System (INIS)

Anklam, T.M.

2011-01-01

Test results from the NIF show excellent progress toward achieving ignition. Experiments designed to verify coupling of the laser energy to the fusion target have shown that the efficiency meets that needed for ignition. Several tests with the cryogenic targets needed for ignition have been performed, and world-record neutron output produced. The National Ignition Campaign is on schedule to meet its 2012 ignition milestone, with the next phase in the campaign due to start later this month. It has been a busy and very productive year. The NIF is in full 24/7 operations and has progressed markedly in the path toward ignition. The long-standing goal of the National Ignition Campaign to demonstrate ignition by the end of FY 2012 is on track. The LIFE plant design has matured considerably, and a delivery plan established based on close interactions with vendors. National-level reviews of fusion are underway, and are due to present initial findings later this year. A value proposition has been drafted for review. The LIFE project is ready to move into the delivery phase.

Regulatory design governing progression of population growth phases in bacteria.

Directory of Open Access Journals (Sweden)

Agustino Martínez-Antonio

Full Text Available It has long been noted that batch cultures inoculated with resting bacteria exhibit a progression of growth phases traditionally labeled lag, exponential, pre-stationary and stationary. However, a detailed molecular description of the mechanisms controlling the transitions between these phases is lacking. A core circuit, formed by a subset of regulatory interactions involving five global transcription factors (FIS, HNS, IHF, RpoS and GadX, has been identified by correlating information from the well- established transcriptional regulatory network of Escherichia coli and genome-wide expression data from cultures in these different growth phases. We propose a functional role for this circuit in controlling progression through these phases. Two alternative hypotheses for controlling the transition between the growth phases are first, a continuous graded adjustment to changing environmental conditions, and second, a discontinuous hysteretic switch at critical thresholds between growth phases. We formulate a simple mathematical model of the core circuit, consisting of differential equations based on the power-law formalism, and show by mathematical and computer-assisted analysis that there are critical conditions among the parameters of the model that can lead to hysteretic switch behavior, which--if validated experimentally--would suggest that the transitions between different growth phases might be analogous to cellular differentiation. Based on these provocative results, we propose experiments to test the alternative hypotheses.

Regulatory design governing progression of population growth phases in bacteria.

Science.gov (United States)

Martínez-Antonio, Agustino; Lomnitz, Jason G; Sandoval, Santiago; Aldana, Maximino; Savageau, Michael A

2012-01-01

It has long been noted that batch cultures inoculated with resting bacteria exhibit a progression of growth phases traditionally labeled lag, exponential, pre-stationary and stationary. However, a detailed molecular description of the mechanisms controlling the transitions between these phases is lacking. A core circuit, formed by a subset of regulatory interactions involving five global transcription factors (FIS, HNS, IHF, RpoS and GadX), has been identified by correlating information from the well- established transcriptional regulatory network of Escherichia coli and genome-wide expression data from cultures in these different growth phases. We propose a functional role for this circuit in controlling progression through these phases. Two alternative hypotheses for controlling the transition between the growth phases are first, a continuous graded adjustment to changing environmental conditions, and second, a discontinuous hysteretic switch at critical thresholds between growth phases. We formulate a simple mathematical model of the core circuit, consisting of differential equations based on the power-law formalism, and show by mathematical and computer-assisted analysis that there are critical conditions among the parameters of the model that can lead to hysteretic switch behavior, which--if validated experimentally--would suggest that the transitions between different growth phases might be analogous to cellular differentiation. Based on these provocative results, we propose experiments to test the alternative hypotheses.

The Effectiveness of the Progression of Widex Zen Tinnitus Therapy: A Pilot Study.

Science.gov (United States)

Tyler, Richard S; Deshpande, Aniruddha K; Lau, Chi C; Kuk, Francis

2017-09-18

The aim of this study was to measure the progression of benefits to individuals with tinnitus from providing informational counseling, hearing aids, a brief tinnitus activities treatment and Zen therapy. Several magnitude estimation scales and tinnitus handicap scales were administered for the duration of the study to 20 participants. Results indicated that all participants benefited from this sequential approach of providing different components of this tinnitus treatment. Large benefits were observed following the tinnitus activities treatment and the Zen treatments. We conclude that the progressive approach of treatment demonstrated here should be of benefit to most individuals with tinnitus and that the Widex Zen sound therapy is a worthwhile treatment for many tinnitus sufferers.

Radioecology of natural systems in Colordao. Fourteenth annual progress report, May 1, 1975--July 31, 1976

International Nuclear Information System (INIS)

Whicker, F.W.

1976-01-01

This report summarizes project activities during the period May 1, 1975 through July 31, 1976. The major study on the distribution and levels of Pu in major components of the terrestrial ecosystem at Rocky Flats was completed. Supportive studies on the ecology and pathology of small mammals and their role in Pu transport were essentially completed as well. Detailed studies on mule deer food habits, population dynamics, and movements at Rocky Flats are progressing. These studies are designed to measure the potential of mule deer in transporting Pu to uncontrolled areas. Alpha autoradiographic studies designed to measure Pu particle size and distribution and spatial patterns in soil were initiated. Field and greenhouse transport pathways from soil to vegetation are in progress and some early results reported. The status of studies on seasonal kinetics of Cs in a montane lake and stable lead geochemistry in an alpine lake watershed are also reported

Advanced light water reactor plants System 80+trademark design certification program. Annual progress report, October 1, 1994 - September 30, 1995

International Nuclear Information System (INIS)

1998-01-01

The purpose of this report is to provide the status of the progress that was made towards Design Certification of System 80+trademark during the US government's 1995 fiscal year. The System 80+ Advanced Light Water Reactor (ALWR) is a 3931 MW (1350 MWe) Pressurized Water Reactor (PWR). The design covers an essentially complete plant. It is based on EPRI ALWR Utility Requirements Document (URD) improvements to the Standardized System 80 Nuclear Steam Supply System (NSSS) in operation at Palo Verde Units 1, 2, and 3. The NSSS is a traditional two-loop arrangement with two steam generators, two hot legs and four cold legs, each with a reactor coolant pump. The System 80+ standard design houses the NSSS in a spherical steel containment vessel which is enclosed in a concrete shield building, thus providing the safety advantages of a dual barrier to radioactivity release. Other major features include an all-digital, human-factors-engineered control room, an alternate electrical AC power source, an In-Containment Refueling Water Storage Tank (IRWST), and plant arrangements providing complete separation of redundant trains in safety systems

Advanced light water reactor plants System 80+trademark design certification program. Annual progress report, October 1, 1995 - September 30, 1996

International Nuclear Information System (INIS)

1996-01-01

The purpose of this report is to provide a status of the progress that was made towards Design Certification of System 80+trademark during the US government's 1996 fiscal year. The System 80+ Advanced Light Water Reactor (ALWR) is a 3931 MW (1350 MWe) Pressurized Water Reactor (PWR). The design covers an essentially complete plant. It is based on EPRI ALWR Utility Requirements Document (URD) improvements to the Standardized System 80 Nuclear Steam Supply System (NSSS) in operation at Palo Verde Units 1, 2 and 3. The NSSS is a traditional two-loop arrangement with two steam generators, two hot legs and four cold legs, each with a reactor coolant pump. The System 80+ standard design houses the NSSS in a spherical steel containment vessel which is enclosed in a concrete shield building, thus providing the safety advantages of a dual barrier to radioactivity release. Other major features include an all-digital, human-factors-engineered control room, an alternate electrical AC power source, an In-Containment Refueling Water Storage Tank (IRWST), and plant arrangements providing complete separation of redundant trains in safety systems

Design study on containers for geological disposal of high-level radioactive waste. Phase 2

International Nuclear Information System (INIS)

1986-01-01

This study has considered the feasibility of three designs for containers which would isolate the waste from the environment for a minimum period of 500 to 1000 years. The candidate container designs were taken from the results of a previous study by Ove Arup and Partners (1985) and were developed as the study progressed. Their major features can be summarized as follows: Type A: A thin-walled corrosion-resistant metal shell filled with lead or cement grout. Type B: An unfilled thick-walled carbon steel shell. Type C: an unfilled carbon steel shell plated externally with corrosion-resistant metal. Reference repository conditions in clay, granite and salt, reference disposal operations and metals corrosion data have been taken from various European Community radioactive waste management research and engineering projects. The study concludes that design types A and B are feasible in manufacturing terms but design Type C is not. Furthermore, a titanium-palladium alloy is considered the most suitable metal for Type A container shells and lead is the preferred filler. The analysis shows that design Types A and B both have adequate resistance to pressure and temperature loadings and both would resist accidental impact damage when upright. A reduction in waste heat output at disposal would lower the stress levels in Type A containers but would have virtually no effect on Type B. There is insufficient data to compare the relative costs and benefits of design Types A and B. In conclusion design Types A and B are both considered feasible but Type A would require more development than Type B. In both cases further research is needed to confirm the long-term corrosion performance of the candidate materials. It is recommended that model containers should be produced to demonstrate the proposed methods of manufacture and that they should be tested to validate the analytical techniques used

Survey of experimental tests about progressive distortion

International Nuclear Information System (INIS)

Clement, Gerard.

1981-02-01

A procedure for evaluation of progressive distorsion experimental data has been set up in CEA. This procedure based on the effective primary stress concept, permits the establishment of a simple design rule. Various published experimental data have been used for verification, validation and generalization of design rule proposed. This rule is compared with existing codified rules (3 Sm, BREE, O'DONNEL and POROWSKI) [fr

A review of progress towards radiative divertor

International Nuclear Information System (INIS)

Zagorski, Roman

1997-07-01

A solution of the problem of the power and particle exhaust from the next step tokamaks, will require new techniques which redistribute the power entering the SOL onto much larger surface area than conventional divertor design permits, while maintaining good impurity retention in divertor volume and allowing for efficient helium pumping. Progress made in developing such techniques is discussed. Status of the modelling studies of dynamic gas target divertor and impurity seeded radiating divertors is presented. Recent results of experiments on radiative and gas target divertors are reviewed

Teaching the Possible: Justice-Oriented Professional Development for Progressive Educators

Directory of Open Access Journals (Sweden)

Mollie A. Gambone

2017-12-01

Full Text Available Providing justice-oriented professional development for progressive educators has historically been a site of tension. To address this, The Progressive Education Network (PEN, the leading professional organization of progressive educators in the United States, brought together over 800 educators for its 2015 National Conference, titled “Teaching the Possible: Access, Equity, and Activism!” This article documents PEN’s framework for facilitating an opportunity for educators to engage in dialogue about areas of social injustice throughout education and within their own schools. Findings derived from a discourse analysis of workshop abstracts published in the conference program suggest that the conference provided professional development in three areas: 1 workshops were designed by teachers to share useful methodologies relevant to the conference theme with other teachers; 2 workshops encouraged attendees to critically examine how problematic issues in education are commonly understood, then reframe them to consider the issues from different perspectives; 3 doing so gave rise to an understanding that in order to imagine innovative solutions to systemic problems, one must first be able understand how different groups of individuals experience the problems. This analysis establishes that by aligning the conference with a critical, justice-oriented theme, the workshops were designed to provide attendees with opportunities to investigate their own roles in producing, changing, and interpreting socially-just learning and teaching in their own school contexts. This is important because it advances the study of equitable access to progressive pedagogy, while at the same time utilizing Desimone’s (2009 framework for judging effective professional development for teachers.

Technical basis for the ITER-FEAT outline design. Progress in resolving open design issues from the outline design report

International Nuclear Information System (INIS)

2000-01-01

In this publication the technical basis for the ITER-FEAT outline design is presented. It comprises the Plant Design Specifications, the Safety Principles and Environmental Criteria, the Site Requirements and Site Design Assumptions. The outline of the key features of the ITER-FEAT design includes main physical parameters and assessment, design overview and preliminary safety assessment, cost and schedule

Progress in blanket designs using SiCf/SiC composites

International Nuclear Information System (INIS)

Giancarli, L.; Golfier, H.; Nishio, S.; Raffray, R.; Wong, C.; Yamada, R.

2002-01-01

This paper summarizes the most recent design activities concerning the use of SiC f /SiC composite as structural material for fusion power reactor breeding blanket. Several studies have been performed in the past. The most recent proposals are the TAURO blanket concept in the European Union, the ARIES-AT concept in the US, and DREAM concept in Japan. The first two concepts are self-cooled lithium-lead blankets, while DREAM is an helium-cooled beryllium/ceramic blanket. Both TAURO and ARIES-AT blankets are essentially formed by a SiC f /SiC box acting as a container for the lithium-lead which has the simultaneous functions of coolant, tritium breeder, neutron multiplier and, finally, tritium carrier. The DREAM blanket is characterized by small modules using pebble beds of Be as neutron multiplier material, of Li 2 O (or other lithium ceramics) as breeder material and of SiC as shielding material. The He coolant path includes a flow through the pebble beds and a porous partition wall. For each blanket, this paper describes the main design features and performances, the most recent design improvements, and the proposed manufacturing routes in order to identify specific issues and requirements for the future R and D on SiC f /SiC

The Progression and Early detection of Subclinical Atherosclerosis (PESA) study

DEFF Research Database (Denmark)

Fernández-Ortiz, Antonio; Jiménez-Borreguero, L Jesús; Peñalvo, José L

2013-01-01

The presence of subclinical atherosclerosis is a likely predictor of cardiovascular events; however, factors associated with the early stages and progression of atherosclerosis are poorly defined.......The presence of subclinical atherosclerosis is a likely predictor of cardiovascular events; however, factors associated with the early stages and progression of atherosclerosis are poorly defined....

Development of Career Progression Systems for Employees in the Foodservice Industry. Final Report.

Science.gov (United States)

National Restaurant Association, Chicago, IL.

Firms representing four segments of the foodservice industry (institutional foodservice (9 jobs), commercial restaurants (19 jobs), hotel foodservice (100 jobs), and airline foodservice (10 jobs), participated in a career and training study to test the feasibility of designing and implementing career progression (c.p.) systems within these…

JSFR design progress related to development of safety design criteria for generation IV sodium-cooled fast reactors. (4) Balance of plant

International Nuclear Information System (INIS)

Chikazawa, Yoshitaka; Katoh, Atsushi; Nabeshima, Kunihiko; Ohtaka, Masahiko; Uzawa, Masayuki; Ikari, Risako; Iwasaki, Mikinori

2015-01-01

In this paper, design study and evaluation related with safety design criteria (SDC) and safety design guideline (SDG) on the balance of plant (BOP) of the demonstration JSFR including fuel handling system, power supply system, component cooling water system, building arrangement are reported. For the fuel handling system, enhancement of storage cooling system has been investigated adding diversified cooling systems. For the power supply, existing emergency power supply system has been reinforced and alternative emergency power supply system is added. For the component cooling system, requirements and relation with safety grade components such investigated. Additionally for the component cooling system, design impact when adding decay heat removal system by sea water has been investigated. For reactor building, over view of evaluation on the external events and design policy for distributed arrangement is reported. Those design study and evaluation provides background information of SDC and SDG. (author)

Selfregulation – the key to progress in clinical reasoning

Directory of Open Access Journals (Sweden)

T Postma

2015-12-01

Full Text Available Background. In 2009 a new case-based instructional design was implemented during the preclinical year of study of the undergraduate dental curriculum of the University of Pretoria, South Africa. The objective of the educational intervention was to improve the development of clinical reasoning skills. To achieve this, systematic scaffolding, relevance, integration and problem-solving were actively promoted as part of teaching and learning. A student’s clinical reasoning was measured by a progress test containing 32 multiple choice questions (MCQs, formulated on a knowledge application level. In 2011 it became clear that some students showed progression while others did not. Objectives. This study was conducted to gauge the value of the case-based intervention with the aim of determining the need for further scaffolding and support, especially for non-progressing students. Methods. The 2011 BChD IV cohort (N=48 was identified for the study. Two semi-structured focus group discussions were conducted. Group 1 (n=8 consisted of students who progressed ≥9%, while group 2 (n=8 comprised students who did not progress to the same extent. Results. Both groups lauded the scaffolding that the case-based curriculum provided. Strategic thinking, goal orientation and self-regulation ability were identified in group 1. A lack of diligence, poor data-processing ability and a possible lack of interest were identified in group 2 students, who were unaware of learning opportunities. Conclusion. There is a need for early identification of students lacking self-regulated learning and for providing timely feedback and support to progressively develop their clinical reasoning skills.

Progress in the planar CPn SOFC system design verification

Energy Technology Data Exchange (ETDEWEB)

Elangovan, S.; Hartvigsen, J.; Khandkar, A. [SOFCo, Salt Lake City, UT (United States)

1996-04-01

SOFCo is developing a high efficiency, modular and scaleable planar SOFC module termed the CPn design. This design has been verified in a 1.4 kW module test operated directly on pipeline natural gas. The design features multistage oxidation of fuel wherein the fuel is consumed incrementally over several stages. High efficiency is achieved by uniform current density distribution per stage, which lowers the stack resistance. Additional benefits include thermal regulation and compactness. Test results from stack modules operating in pipeline natural gas are presented.

Progress on study of nuclear data theory and related fields at the Theory Group of CNDC

Energy Technology Data Exchange (ETDEWEB)

Zhigang, Ge [China Nuclear Data Center, CIAE (China)

1996-06-01

The Theory Group of CNDC (China Nuclear Data Center) has made a lot of progress in nuclear reaction theory and its application as well as many other related fields in 1995. The recent progress in nuclear reaction theory study and its applications, the recent progress in the nuclear data calculation and related code development are introduced. The production rate of radioactive nuclear beam induced by 70 MeV protons on {sup 72}Ge target were calculated. The calculated results are presented.

Gene expression study and pathway analysis of histological subtypes of intestinal metaplasia that progress to gastric cancer.

Directory of Open Access Journals (Sweden)

Osmel Companioni

Full Text Available Intestinal metaplasia (IM is a precursor lesion that precedes gastric cancer (GC. There are two IM histological subtypes, complete (CIM and incomplete (IIM, the latter having higher progression rates to GC. This study was aimed at analysing gene expression and molecular processes involved in the progression from normal mucosa to IM, and also from IM subtypes to GC.We used expression data to compare the transcriptome of healthy gastric mucosa to that of IM not progressing to GC, and the transcriptome of IM subtypes that had progressed to GC to those that did not progress. Some deregulated genes were validated and pathway analyses were performed.Comparison of IM subtypes that had progressed to GC with those that did not progress showed smaller differences in the expression profiles than the comparison of IM that did not progress with healthy mucosa. New transcripts identified in IM not progressing to GC included TRIM, TMEM, homeobox and transporter genes and SNORD116. Comparison to normal mucosa identified non tumoral Warburg effect and melatonin degradation as previously unreported processes involved in IM. Overexpressed antigen processing is common to both IM-subtypes progressing to GC, but IIM showed more over-expressed oncogenic genes and molecular processes than CIM.There are greater differences in gene expression and molecular processes involved in the progression from normal healthy mucosa to IM than from IM to gastric cancer. While antigen processing is common in both IM-subtypes progressing to GC, more oncogenic processes are observed in the progression of IIM.

Process development studies on the bioconversion of cellulose and production of ethanol. Progress report, September 1, 1978

Energy Technology Data Exchange (ETDEWEB)

Wilke, C.R.

1978-09-01

Progress is reported in studies on the pretreatment of cellulosic materials to facilitate enzymatic hydrolysis, sulfuric acid hydrolysis, investigation of the Purdue processing scheme including an economic analysis, and the fermentability of the enzymatic hydrolyzate. Progress is also reported on enzyme fermentation studies, hydrolysis reactor development, and utilization of hemicellulose sugars. (JSR)

Comparative analysis of station blackout accident progression in typical PWR, BWR, and PHWR

International Nuclear Information System (INIS)

Park, Soo Young; Ahn, Kwang Il

2012-01-01

Since the crisis at the Fukushima plants, severe accident progression during a station blackout accident in nuclear power plants is recognized as a very important area for accident management and emergency planning. The purpose of this study is to investigate the comparative characteristics of anticipated severe accident progression among the three typical types of nuclear reactors. A station blackout scenario, where all off-site power is lost and the diesel generators fail, is simulated as an initiating event of a severe accident sequence. In this study a comparative analysis was performed for typical pressurized water reactor (PWR), boiling water reactor (BWR), and pressurized heavy water reactor (PHWR). The study includes the summarization of design differences that would impact severe accident progressions, thermal hydraulic/severe accident phenomenological analysis during a station blackout initiated-severe accident; and an investigation of the core damage process, both within the reactor vessel before it fails and in the containment afterwards, and the resultant impact on the containment.

Reactor technology. Progress report, January--March 1978

International Nuclear Information System (INIS)

Warren, J.L.

1978-07-01

Progress is reported in eight program areas. The nuclear Space Electric Power Supply Program examined safety questions in the aftermath of the COSMOS 954 incident, examined the use of thermoelectric converters, examined the neutronic effectiveness of various reflecting materials, examined ways of connecting heat pipes to one another, studied the consequences of the failure of one heat pipe in the reactor core, and did conceptual design work on heat radiators for various power supplies. The Heat Pipe Program reported progress in the design of ceramic heat pipes, new application of heat pipes to solar collectors, and final performance tests of two pipes for HEDL applications. Under the Nuclear Process Heat Program, work continues on computer codes to model a pebble bed high-temperature gas-cooled reactor, adaptation of a set of German reactor calculation codes to use on U.S. computers, and a parametric study of a certain resonance integral required in reactor studies. Under the Nonproliferation Alternative Sources Assessment Program LASL has undertaken an evaluation of a study of gaseous core reactors by Southern Science Applications, Inc. Independently LASL has developed a proposal for a comprehensive study of gaseous uranium-fueled reactor technology. The Plasma Core Reactor Program has concentrated on restacking the beryllium reflector and redesigning the nuclear control system. The status of and experiments on four critical assemblies, SKUA, Godiva IV, Big Ten, and Flattop, are reported. The Nuclear Criticality Safety Program carried out several tasks including conducting a course, doing several annual safety reviews and evaluating the safety of two Nevada test devices. During the quarter one of the groups involved in reactor technology has acquired responsibility for the operation of a Cockroft-Walton accelerator. The present report contains information on the use of machine and improvements being made in its operation

Design of patterned sapphire substrates for GaN-based light-emitting diodes

International Nuclear Information System (INIS)

Wang Hai-Yan; Lin Zhi-Ting; Han Jing-Lei; Zhong Li-Yi; Li Guo-Qiang

2015-01-01

A new method for patterned sapphire substrate (PSS) design is developed and proven to be reliable and cost-effective. As progress is made with LEDs’ luminous efficiency, the pattern units of PSS become more complicated, and the effect of complicated geometrical features is almost impossible to study systematically by experiments only. By employing our new method, the influence of pattern parameters can be systematically studied, and various novel patterns are designed and optimized within a reasonable time span, with great improvement in LEDs’ light extraction efficiency (LEE). Clearly, PSS pattern design with such a method deserves particular attention. We foresee that GaN-based LEDs on these newly designed PSSs will achieve more progress in the coming years. (topical review)

Progress Report: Feasibility Study of an Indium Scintillator Solar Neutrino Experiment

International Nuclear Information System (INIS)

Bellefon, A. de; Barloutaud, R.; Borg, A.; Ernwein, J.; Mosca, L.

1989-09-01

In this document, we report on the progress made to demonstrate the feasibility of an experiment which would measure for the first time the two line sources of solar neutrinos resulting from electron capture by 7 Be and from the p-e-p reaction inside the sun. The detector under study consists of scintillator containing 10 tons of Indium

Does a Progressive PIT Stabilize the Economy? A Comparison of Progressive and Flat Taxes

Directory of Open Access Journals (Sweden)

Krajewski Piotr

2017-03-01

Full Text Available The aim of the article is to examine the impact of progressive personal income tax rates and the effectiveness of this tax as an automatic economic stabilizer. The assessment of automatic stabilizers is based on the estimates of tax cyclical components. The study shows that the output elasticity of PIT is higher than one, which means that the analysed tax acts relatively efficiently as an automatic stabilizer. However, it was also observed that the tax progressivity is not the main reason of the effectiveness of a progressive PIT as an automatic stabilizer. The study shows that changes in progressive rates of PIT, contrary to widespread opinions, have little effect on the effectiveness of passive fiscal policy. Personal income tax acts as automatic stabilizer mostly due not to the progressive tax rates, but because of the sensitivity of employment to GDP fluctuations.

Basic studies of atomic dynamics. Progress report for period October 1, 1977--September 30, 1978

International Nuclear Information System (INIS)

Fano, U.

1978-01-01

Novel and unexpected progress was achieved this year on the interaction of an electron with a polar molecule, by introducing an adiabatic procedure of progressive frame transformation whose adiabatic channels are determined by solving a two-variable non-separable problem. This success and the requirements of other tasks have increased interest in unraveling the significance of approximations based on separability of variables and adiabaticity whose success keeps exceeding expectations. Efforts in this direction are just beginning. Promising progress has also been achieved in calculations of a pair of correlated electrons in the field of an ion rather than of a bare nucleus. This work centers on the states of K - . The theory of crystal electron states with point symmetry about an impurity has made further progress but it has reached now a stopping point still short of its ultimate goal. The study of symmetries in atomic processes by tensorial methods has made much progress, thanks primarily to experimentalists interested in exploiting or refining their work. A list of reports is included

Final definition and preliminary design study for the initial atmospheric cloud physics laboratory, a spacelab mission payload

Science.gov (United States)

1976-01-01

The Atmospheric Cloud Physics Laboratory (ACPL) task flow is shown. Current progress is identified. The requirements generated in task 1 have been used to formulate an initial ACPL baseline design concept. ACPL design/functional features are illustrated. A timetable is presented of the routines for ACPL integration with the spacelab system.

Influence of comorbidities on therapeutic progression of diabetes treatment in Australian veterans: a cohort study.

Directory of Open Access Journals (Sweden)

Agnes I Vitry

Full Text Available BACKGROUND: This study assessed whether the number of comorbid conditions unrelated to diabetes was associated with a delay in therapeutic progression of diabetes treatment in Australian veterans. METHODOLOGY/PRINCIPAL FINDINGS: A retrospective cohort study was undertaken using data from the Australian Department of Veterans' Affairs (DVA claims database between July 2000 and June 2008. The study included new users of metformin or sulfonylurea medicines. The outcome was the time to addition or switch to another antidiabetic treatment. The total number of comorbid conditions unrelated to diabetes was identified using the pharmaceutical-based comorbidity index, Rx-Risk-V. Competing risk regression analyses were conducted, with adjustments for a number of covariates that included age, gender, residential status, use of endocrinology service, number of hospitalisation episodes and adherence to diabetes medicines. Overall, 20,134 veterans were included in the study. At one year, 23.5% of patients with diabetes had a second medicine added or had switched to another medicine, with 41.4% progressing by 4 years. The number of unrelated comorbidities was significantly associated with the time to addition of an antidiabetic medicine or switch to insulin (subhazard ratio [SHR] 0.87 [95% CI 0.84-0.91], P<0.001. Depression, cancer, chronic obstructive pulmonary disease, dementia, and Parkinson's disease were individually associated with a decreased likelihood of therapeutic progression. Age, residential status, number of hospitalisations and adherence to anti-diabetic medicines delayed therapeutic progression. CONCLUSIONS/SIGNIFICANCE: Increasing numbers of unrelated conditions decreased the likelihood of therapeutic progression in veterans with diabetes. These results have implications for the development of quality measures, clinical guidelines and the construction of models of care for management of diabetes in elderly people with comorbidities.

Overweight and obesity are progressively associated with lower work ability in the general working population: cross-sectional study among 10,000 adults.

Science.gov (United States)

Andersen, Lars L; Izquierdo, Mikel; Sundstrup, Emil

2017-11-01

Obesity is associated with many diseases and functional limitations. Workplaces are not always designed to accommodate this challenge. This study investigated the association between body mass index (BMI) and work ability in the general working population. Currently employed wage earners (N = 10,427) from the 2010 round of the Danish Work Environment Cohort Study (DWECS) replied to questions about work and health. Cumulative logistic regression analyses controlling for age, gender, physical and psychosocial work factors, lifestyle, and chronic diseases modeled the associations between BMI and work ability. BMIs above the normal range were progressively associated with lower work ability in relation to the physical demands of the job. Odds ratios for having lower work ability were 1.11 (95% CI 1.01-1.22), 1.17 (95% CI 1.01-1.34), 1.43 (95% CI 1.09-1.88), 1.69 (95% CI 1.10-2.62) for overweight and obesity classes I, II, and III, respectively. In subgroup analyses, the associations between BMI and work ability were more pronounced among individuals with mainly sedentary work than among those with physically active work. BMI was not associated with work ability in relation to the mental demands of the work. BMIs above the normal range are progressively associated with lower work ability in relation to the physical demands of the job, especially among individuals with mainly sedentary work. Ergonomic research on how to optimally design workstations for workers with obesity are needed.

Waveform design for wireless power transfer

OpenAIRE

Clerckx, B; Bayguzina, E

2016-01-01

Far-field Wireless Power Transfer (WPT) has attracted significant attention in recent years. Despite the rapid progress, the emphasis of the research community in the last decade has remained largely concentrated on improving the design of energy harvester (so-called rectenna) and has left aside the effect of transmitter design. In this paper, we study the design of transmit waveform so as to enhance the DC power at the output of the rectenna. We derive a tractable model of the non-linearity ...

The U.S. RERTR program status and progress

International Nuclear Information System (INIS)

Travelli, A.

1998-01-01

The progress of the Reduced Enrichment Research and Test Reactor (RERTR) Program since its inception in 1978 is described. A brief summary of the results which the RERTR Program had achieved by the end of 1996 in collaboration with its many international partners is followed by a detailed review of the major events, findings, and activities of 1997. Significant progress has been made during the past year. In the area of U.S. acceptance of spent fuel from foreign research reactors, several shipments have taken place and additional are being planned. Intense fuel development activities are in progress, including procurement of equipment, screening of candidate materials, and production of microplates. Irradiation of the first series of microplates began in August 1997 in the Advanced Test Reactor, in Idaho. Progress has been made in the Russian RERTR program, which aims to develop and demonstrate within five years the technical means needed to convert Russian-supplied research reactors to LEU fuels. The study of an alternative LEU core for the FRM-II design has been extended to address, with favorable results, controversial performance issues which were raised at last year's meeting. Progress was also made on several aspects of producing molybdenum-99 from fission targets utilizing LEU instead of HEU. Various types of targets and processes are being pursued, with FDA approval of an LEU process projected to occur within two years. The feasibility of LEU Fuel conversion for three important DOE research reactors (BMRR, HFBR, and HFIR) has been evaluated by the RERTR program. In spite of the many momentous events which have occurred during the intervening years, and the excellent progress achieved, the most important challenges that the RERTR program faces today are not very different in type from those that were faced during the first RERTR meeting. Now, as then, the most important task is to develop new LEU fuels satisfying requirements which cannot be satisfied by any

The U.S. RERTR Program. Status and progress

International Nuclear Information System (INIS)

Travelli, A.

1997-01-01

The progress of the Reduced Enrichment Research and Test Reactor (RERTR) Program since its inception in 1978 is described. A brief summary of the results which the RERTR Program had achieved by the end of 1996 in collaboration with its many international partners is followed by a detailed review of the major events, findings, and activities of 1997. Significant progress has been made during the past year. In the area of U.S. acceptance of spent fuel from foreign research reactors, several shipments have taken place and additional are being planned. Intense fuel development activities are in progress, including procurement of equipment, screening of candidate materials, and production of microplates. Irradiation of the first series of microplates began in August 1997 in the Advanced Test Reactor, in Idaho. Progress has been made in the Russian RERTR program, which aims to develop and demonstrate within five years the technical means needed to convert Russian-supplied research reactors to LEU fuels. The study of an alternative LEU core for the FRM-II design has been extended to address, with favorable results, controversial performance issues which were raised at last year's meeting. Progress was also made on several aspects of producing molybdenum-99 from fission targets utilizing LEU instead of HEU. Various types of targets and processes are being pursued, with FDA approval of an LEU process projected to occur within two years. The feasibility of LEU fuel conversion for three important DOE research reactors (BMRR, HFBR, and HFIR) has been evaluated by the RERTR program. In spite of the many momentous events which have occurred during the intervening years, and the excellent progress achieved, the most important challenges that the RERTR program faces today are not very different in type from those that were faced during the first RERTR meeting. Now, as then, the most important task is to develop new LEU fuels satisfying requirements which cannot be satisfied by any

Teleosts Genomics: Progress and Prospects in Disease Prevention and Control.

Science.gov (United States)

Munang'andu, Hetron Mweemba; Galindo-Villegas, Jorge; David, Lior

2018-04-04

Genome wide studies based on conventional molecular tools and upcoming omics technologies are beginning to gain functional applications in the control and prevention of diseases in teleosts fish. Herein, we provide insights into current progress and prospects in the use genomics studies for the control and prevention of fish diseases. Metagenomics has emerged to be an important tool used to identify emerging infectious diseases for the timely design of rational disease control strategies, determining microbial compositions in different aquatic environments used for fish farming and the use of host microbiota to monitor the health status of fish. Expounding the use of antimicrobial peptides (AMPs) as therapeutic agents against different pathogens as well as elucidating their role in tissue regeneration is another vital aspect of genomics studies that had taken precedent in recent years. In vaccine development, prospects made include the identification of highly immunogenic proteins for use in recombinant vaccine designs as well as identifying gene signatures that correlate with protective immunity for use as benchmarks in optimizing vaccine efficacy. Progress in quantitative trait loci (QTL) mapping is beginning to yield considerable success in identifying resistant traits against some of the highly infectious diseases that have previously ravaged the aquaculture industry. Altogether, the synopsis put forth shows that genomics studies are beginning to yield positive contribution in the prevention and control of fish diseases in aquaculture.

Teleosts Genomics: Progress and Prospects in Disease Prevention and Control

Directory of Open Access Journals (Sweden)

Hetron Mweemba Munang’andu

2018-04-01

Full Text Available Genome wide studies based on conventional molecular tools and upcoming omics technologies are beginning to gain functional applications in the control and prevention of diseases in teleosts fish. Herein, we provide insights into current progress and prospects in the use genomics studies for the control and prevention of fish diseases. Metagenomics has emerged to be an important tool used to identify emerging infectious diseases for the timely design of rational disease control strategies, determining microbial compositions in different aquatic environments used for fish farming and the use of host microbiota to monitor the health status of fish. Expounding the use of antimicrobial peptides (AMPs as therapeutic agents against different pathogens as well as elucidating their role in tissue regeneration is another vital aspect of genomics studies that had taken precedent in recent years. In vaccine development, prospects made include the identification of highly immunogenic proteins for use in recombinant vaccine designs as well as identifying gene signatures that correlate with protective immunity for use as benchmarks in optimizing vaccine efficacy. Progress in quantitative trait loci (QTL mapping is beginning to yield considerable success in identifying resistant traits against some of the highly infectious diseases that have previously ravaged the aquaculture industry. Altogether, the synopsis put forth shows that genomics studies are beginning to yield positive contribution in the prevention and control of fish diseases in aquaculture.

Quantitative studies in radiopharmaceutical science. Progress report, April 1-August 31, 1986

International Nuclear Information System (INIS)

Cooper, M.

1986-09-01

This report covers progress made during the first reporting period since the redirection of the project. In radiochemistry, achievements in fluorine-18 tracer studies including purification and reaction kinetics of 2-fluorodeoxyglucose and production of 6-fluoroDOPA. Radiopharmaceuticals have been prepared and tested for studies on CNS dopaminergic systems. By use of dynamic positron emission tomography the cerebral transport and metabolism of glucose continues to be studied. 6 figs

Determination of lactic acid level in systemic liquids in children with progressive encephalopathies.

Science.gov (United States)

Marszał, Elzbieta; Wojaczyńska-Stanek, Katarzyna; Pietruszewski, Jerzy; Emich-Widera, Ewa; Bielińska-Bujniewicz, Eugenia

2002-03-01

This article reports the results of research into the activities of lactic acid concentrations in the body fluids of children with progressive encephalopathies (PE) in comparison to patients with non-progressive encephalopathies (NPE) and those with non-progressive encephalopathies with concomitant epilepsy (NPEE). The study was designed to determine whether there is difference between the serum and CSF lactic acid concentrations in children with progressive encephalopathies (PE), static (non-progressive) encephalopathies (NPE) and non progressive encephalopathies with concomitant epilepsy (NPEE), and whether the clinical status correlates with the concentration of these biochemical markers in children with PE. The assessment involved 138 children of both sexes, whose age ranged between 8 months and 15 years, diagnosed and treated in the Neurology Department at the Pediatric Clinic of the Silesian Medical Academy in Katowice between 1995 and 1997. Lactate concentrations were determined in serum and cerebro-spinal fluid and analyzed statistically. The findings showed higher serum and CSF concentrations in children with PE than in patients who manifested non-progressive forms of encephalopathy. The degree of clinical symptom aggravation in PE children was likewise analyzed and compared to the values of lactate concentrations in body fluids; however, no correlation was found between these parameters. Children with progressive encephalopathies present higher lactate concentrations in serum and cerebrospinal fluid than patients with static (non-progressive) encephalopathy.

/sup 131/I albumin study of patients carrying progressive systemic sclerosis

Energy Technology Data Exchange (ETDEWEB)

Cossermelli, W; Carvalho, N; Papaleo Netto, M [Sao Paulo Univ. (Brazil). Centro de Medicina Nuclear

1974-05-01

/sup 131/I albumin metabolic changes were studied in 14 female patients with progressive systemic sclerosis. A statistical study of the gathered data disclosed increased distribution and turnover half-life and diminished turnover rate of radioactive substance. Since T/2 of turnover and turnover rate are the result produced by the albumin synthesis and degradation, they are probably lowered during active disease causing hypoalbuminemia. The aminoacids also are probably absorbed by other protein like the gammaglobuline synthesis.

Space reactors. Progress report, October 1981-March 1982

International Nuclear Information System (INIS)

Ranken, W.A.

1983-01-01

Progress in design studies and technology for the SP-100 Project - successor to the Space Power Advanced Reactor (SPAR) Project - is reported for the period October 1, 1981 to March 31, 1982. The basis for selecting a high-temperature, UO 2 -fueled, heat-pipe-cooled reactor with a thermoelectric conversion system as the 100-kW/sub e/ reference design has been reviewed. Although no change has been made in the general concept, design studies have been done to investigate various reactor/conversion system coupling methods and core design modifications. Thermal and mechanical finite element modeling and three-dimensional Monte Carlo analysis of a core with individual finned fuel elements are reported. Studies of unrestrained fuel irradiation data are discussed that are relevant both to the core modeling work and to the design and fabrication of the first in-pile irradiation test, which is also reported. Work on lithium-filled core heat pipe development is described, including the attainment of 15.6 kW/sub t/ operation at 1525 K for a 2-m-long heat pipe with a 15.7-mm outside diameter. The successful operation of a 5.5-m-long, lightweight potassium/titanium heat pipe at 760 K is described, and test results of a thermoelectric module with GaP-modified SiGe thermoelectric elements are presented

Lipoprotein subclasses in the Monitored Atherosclerosis Regression Study (MARS). Treatment effects and relation to coronary angiographic progression.

Science.gov (United States)

Mack, W J; Krauss, R M; Hodis, H N

1996-05-01

Accumulating evidence suggests that triglyceride-rich lipoproteins contribute to coronary artery disease. Using data from the Monitored Atherosclerosis Regression Study, an angiographic trial of middle-aged men and women randomized to lovastatin or placebo, we investigated relationships between lipoprotein subclasses and progression of coronary artery atherosclerosis. Coronary artery lesion progression was determined by quantitative coronary angiography in low-grade ( or = 50% diameter stenosis), and all coronary artery lesions in 220 baseline/2-year angiogram pairs. Analytical ultracentrifugation was used to measure lipoprotein masses that were statistically evaluated for treatment group differences and relationships to progression of coronary artery atherosclerosis. All low density lipoprotein (LDL), intermediate density lipoprotein (IDL), and very low density lipoprotein (VLDL) masses were significantly lowered and all high density lipoprotein (HDL) masses were significantly raised with lovastatin therapy. The mass of smallest LDL (Svedberg flotation rate [Sf] 0 to 3), IDL (Sf 12 to 20), all VLDL subclasses (Sf 20 to 60, Sf 60 to 100, and Sf 100 to 400), and peak LDL flotation rate were significantly related to the progression of coronary artery lesions, specifically low-grade lesions. Greater baseline levels of HDL3, were related to a lower likelihood of coronary artery lesion progression. In multivariate analyses, small VLDL (Sf 20 to 60) and HDL3 mass were the most important correlates of coronary artery lesion progression. These results provide further evidence for the importance of triglyceride-rich lipoproteins in the progression of coronary artery disease. In addition, these results present new evidence for the possible protective role of HDL3 in the progression of coronary artery lesions. More specific information on coronary artery lesion progression may be obtained through the study of specific apolipoprotein B-containing lipoproteins.

Theoretical studies in hadronic and nuclear physics. Progress report, December 1, 1993--June 30, 1994

International Nuclear Information System (INIS)

Cohen, T.D.; Banerjee, M.K.

1994-07-01

Under Hadrons in Nuclei and Nuclear Matter the authors research the ways in which the properties of nucleons and mesons are modified in the nuclear medium. Research progress is reported on a number of topics in this general area, including studies of the role of chiral symmetry for finite density or temperature nuclear matter, the use of QCD sum rules to describe baryons in nuclear matter, and color transparency. In the general field of Hadron Physics broad progress included studies of perturbative QCD, heavy quark physics, QCD sum rules, and QCD-based models. Notable progress was also achieved in Relativistic Dynamics in Quark, Hadron, and Nuclear Physics, where an explicit model of composite particles shows how the z-graph physics (which is an essential part of Dirac phenomenology) comes about. In addition, calculations of elastic electron-deuteron scattering based on two-body relativistic dynamics and meson exchange currents were completed, as were studies of quark-anti-quark bound states based on a relativistic quark model. Progress is also reported on the relativistic few-body problem. In the area of Heavy Ion Dynamics and Sharp Lepton Pairs, work continues on the Composite Particle Scenario for the 'Sharp Lepton Problem'. In particular, the scenario can now encompass the anomalous sharp leptons reported from positron irradiation of heavy neutral atoms, establishing such irradiations as an alternative experimental window to the heavy ion experiments

Nursing documentation in inpatient psychiatry: The relevance of nurse-patient interactions in progress notes-A focus group study with mental health staff.

Science.gov (United States)

Myklebust, Kjellaug K; Bjørkly, Stål; Råheim, Målfrid

2018-02-01

To gain insight into mental health staff's perception of writing progress notes in an acute and subacute psychiatric ward context. The nursing process structures nursing documentation. Progress notes are intended to be an evaluation of a patient's nursing diagnoses, interventions and outcomes. Within this template, a patient's status and the care provided are to be recorded. The therapeutic nurse-patient relationship is recognised as a key component of psychiatric care today. At the same time, the biomedical model remains strong. Research literature exploring nursing staff's experiences with writing progress notes in psychiatric contexts, and especially the space given to staff-patient relations, is sparse. Qualitative design. Focus group interviews with mental health staff working in one acute and one subacute psychiatric ward were conducted. Systematic text condensation, a method for transverse thematic analysis, was used. Two main categories emerged from the analysis: the position of the professional as an expert and distant observer in the progress notes, and the weak position of professional-patient interactions in progress notes. The participants did not perceive that the current recording model, which is based on the nursing process, supported a focus on patients' resources or reporting professional-patient interactions. This model appeared to put ward staff in an expert position in relation to patients, which made it challenging to involve patients in the recording process. Essential aspects of nursing care related to recovery and person-centred care were not prioritised for documentation. This study contributes to the critical examination of the documentation praxis, as well as to the critical examination of the documentation tool as to what is considered important to document. © 2017 John Wiley & Sons Ltd.

Nuclear spectroscopic studies. Progress report, June 1, 1983-May 31, 1984

International Nuclear Information System (INIS)

Bingham, C.R.; Guidry, M.W.; Riedinger, L.L.

1984-01-01

Progress is reported on nuclear structure and nuclear reaction studies utilizing heavy-ion beams. Projects at the HHIRF, the Brookhaven Tandem Accelerator, and the Nuclear Science Facility at Daresbury, England are described. Studies have been concentrated on: (1) the structure of deformed and transitional nuclei in the angular momentum range from 20 to 40 h by (HI,xn) reactions; (2) the 1- and 2-nucleon transfer reactions between spherical heavy ion projectiles and deformed targets; and (3) the low-energy properties of nuclei far from stability. Theoretical studies are also reported. Publications are listed

Experimental study of interactions of highly charged ions with atoms at keV energies. Progress report, February 16, 1993--April 15, 1994

International Nuclear Information System (INIS)

Kostroun, V.O.

1994-01-01

Experimental study of low energy, highly charged ions with other atomic species requires an advanced ion source such as an electron beam ion source, EBIS or an electron cyclotron ion source, ECRIS. Five years ago we finished the design and construction of the Cornell superconducting solenoid, cryogenic EBIS (CEBIS). Since then, this source has been in continuous operation in a program whose main purpose is the experimental study of interactions of highly charged ions with atoms at keV energies. This progress report for the period February 16, 1993 to April 15, 1994 describes the work accomplished during this time in the form of short abstracts

Progressive Damage Modeling of Durable Bonded Joint Technology

Science.gov (United States)

Leone, Frank A.; Davila, Carlos G.; Lin, Shih-Yung; Smeltzer, Stan; Girolamo, Donato; Ghose, Sayata; Guzman, Juan C.; McCarville, Duglas A.

2013-01-01

The development of durable bonded joint technology for assembling composite structures for launch vehicles is being pursued for the U.S. Space Launch System. The present work is related to the development and application of progressive damage modeling techniques to bonded joint technology applicable to a wide range of sandwich structures for a Heavy Lift Launch Vehicle. The joint designs studied in this work include a conventional composite splice joint and a NASA-patented Durable Redundant Joint. Both designs involve a honeycomb sandwich with carbon/epoxy facesheets joined with adhesively bonded doublers. Progressive damage modeling allows for the prediction of the initiation and evolution of damage. For structures that include multiple materials, the number of potential failure mechanisms that must be considered increases the complexity of the analyses. Potential failure mechanisms include fiber fracture, matrix cracking, delamination, core crushing, adhesive failure, and their interactions. The joints were modeled using Abaqus parametric finite element models, in which damage was modeled with user-written subroutines. Each ply was meshed discretely, and layers of cohesive elements were used to account for delaminations and to model the adhesive layers. Good correlation with experimental results was achieved both in terms of load-displacement history and predicted failure mechanisms.

GT-MHR COMMERCIALZATION STUDY. TECHNICAL PROGRESS AND COST MANAGEMENT REPORT FOR THE PERIOD JUNE 1 THROUGH JUNE 30, 2003

International Nuclear Information System (INIS)

SHENOY, A.S.

2003-01-01

A271 GT-MHR COMMERCIALZATION STUDY TECHNICAL PROGRESS AND COST MANAGEMENT REPORT FOR THE PERIOD JUNE 1 THROUGH JUNE 30, 2003. Petten was provided with irradiation dimensional change data for both fuel compacts and H-451 graphite for design of the graphite sleeves that hold the fuel compacts to be irradiated in HFR-EU2. The Fuel Sample Product Specification for the Fuel Performance Irradiation Test Capsule MHR-2 was completed and approved. A Work Breakdown Structure was prepared for the development and qualification of advanced coated-particle fuels capable of meeting anticipated fuel performance requirements and work was initiated on preparation of schedules and a cost estimates for the test matrices

Muon collider progress

Energy Technology Data Exchange (ETDEWEB)

Noble, Robert J. FNAL

1998-08-01

Recent progress in the study of muon colliders is presented. An international collaboration consisting of over 100 individuals is involved in calculations and experiments to demonstrate the feasibility of this new type of lepton collider. Theoretical efforts are now concentrated on low-energy colliders in the 100 to 500 GeV center-of-mass energy range. Credible machine designs are emerging for much of a hypothetical complex from proton source to the final collider. Ionization cooling has been the most difficult part of the concept, and more powerful simulation tools are now in place to develop workable schemes. A collaboration proposal for a muon cooling experiment has been presented to the Fermilab Physics Advisory Committee, and a proposal for a targetry and pion collection channel experiment at Brookhaven National Laboratory is in preparation. Initial proton bunching and space-charge compensation experiments at existing hadron facilities have occurred to demonstrate proton driver feasibility.

Advanced light water reactor plants System 80+{trademark} design certification program. Annual progress report, October 1, 1994--September 30, 1995

Energy Technology Data Exchange (ETDEWEB)

NONE

1998-09-01

The purpose of this report is to provide the status of the progress that was made towards Design Certification of System 80+{trademark} during the US government`s 1995 fiscal year. The System 80+ Advanced Light Water Reactor (ALWR) is a 3931 MW (1350 MWe) Pressurized Water Reactor (PWR). The design covers an essentially complete plant. It is based on EPRI ALWR Utility Requirements Document (URD) improvements to the Standardized System 80 Nuclear Steam Supply System (NSSS) in operation at Palo Verde Units 1, 2, and 3. The NSSS is a traditional two-loop arrangement with two steam generators, two hot legs and four cold legs, each with a reactor coolant pump. The System 80+ standard design houses the NSSS in a spherical steel containment vessel which is enclosed in a concrete shield building, thus providing the safety advantages of a dual barrier to radioactivity release. Other major features include an all-digital, human-factors-engineered control room, an alternate electrical AC power source, an In-Containment Refueling Water Storage Tank (IRWST), and plant arrangements providing complete separation of redundant trains in safety systems.

Design Games

DEFF Research Database (Denmark)

Johansson, Martin Wetterstrand

2007-01-01

In this paper design games are discussed as an approach to managing design sessions. The focus is on the collaborative design session and more particular on how to set up the collaboration and reinsure progress. Design games have the advantage of framing the collaborative assignment at hand....... Experiments can be set up to explore possible futures and design games has the qualities of elegantly focus the work at the same time as it lessens the burden for the process facilitator. The present paper goes into detail about how design games can be set up to facilitate collaboration and how the design...

Progress in studies of Electron-Cloud-Induced Optics Distortions at CESRTA

International Nuclear Information System (INIS)

Crittenden, J.A.; Calvey, J.R.; Dugan, G.F.; Kreinick, D.L.; Leong, Z.; Livezey, J.A.; Palmer, M.A.; Rubin, D.L.; Sagan, D.C.; Holtzapple, R.L.; Furman, M.A.; Penn, G.; Venturini, M.; Pivi, M.; Wang, L.; Harkay, K.

2010-01-01

The Cornell Electron Storage Ring Test Accelerator (CesrTA) program has included extensive measurements of coherent betatron tune shifts for a variety of electron and positron beam energies, bunch population levels, and bunch train configurations. The tune shifts have been shown to result primarily from the interaction of the beam with the space-charge field of the beam-induced low energy electron cloud in the vacuum chamber. Comparison to several advanced electron cloud simulation program packages has allowed determination of the sensitivity of these measurements to physical parameters characterizing the synchrotron radiation flux, the production of photoelectrons on the vacuum chamberwall, the beam emittance, lattice optics, and the secondary-electron yield model. We report on progress in understanding the cloud buildup and decay mechanisms in magnetic fields and in field-free regions, addressing quantitatively the precise determination of the physical parameters of the modeling. Validation of these models will serve as essential input in the design of damping rings for future high-energy linear colliders.

Studies of elementary particles: Progress report and proposal

International Nuclear Information System (INIS)

Chapman, J.W.

1988-01-01

This progress report discusses the following High Energy Physics topics: the IMB/MIA detector; the MKII/HRS detector; the cosmic gamma-ray experiment; computer and instrumentation services; the MACRO detector; the DO detector; and spin physics

Periodontal Pocket Depth, Hyperglycemia, and Progression of Chronic Kidney Disease: A Population-Based Longitudinal Study.

Science.gov (United States)

Chang, Jia-Feng; Yeh, Jih-Chen; Chiu, Ya-Lin; Liou, Jian-Chiun; Hsiung, Jing-Ru; Tung, Tao-Hsin

2017-01-01

No large epidemiological study has been conducted to investigate the interaction and joint effects of periodontal pocket depth and hyperglycemia on progression of chronic kidney disease in patients with periodontal diseases. Periodontal pocket depth was utilized for the grading severity of periodontal disease in 2831 patients from January 2002 to June 2013. Progression of chronic kidney disease was defined as progression of color intensity in glomerular filtration rate and albuminuria grid of updated Kidney Disease-Improving Global Outcomes guidelines. Multivariable-adjusted hazard ratios (aHR) in various models were presented across different levels of periodontal pocket depth and hemoglobin A1c (HbA1c) in forest plots and 3-dimensional histograms. During 7621 person-years of follow-up, periodontal pocket depth and HbA1C levels were robustly associated with incremental risks for progression of chronic kidney disease (aHR 3.1; 95% confidence interval [CI], 2.0-4.6 for periodontal pocket depth >4.5 mm, and 2.5; 95% CI, 1.1-5.4 for HbA1C >6.5%, respectively). The interaction between periodontal pocket depth and HbA1C on progression of chronic kidney disease was strong (P periodontal pocket depth (>4.5 mm) and higher HbA1C (>6.5%) had the greatest risk (aHR 4.2; 95% CI, 1.7-6.8) compared with the lowest aHR group (periodontal pocket depth ≤3.8 mm and HbA1C ≤6%). Our study identified combined periodontal pocket depth and HbA1C as a valuable predictor of progression of chronic kidney disease in patients with periodontal diseases. While considering the interaction between periodontal diseases and hyperglycemia, periodontal survey and optimizing glycemic control are warranted to minimize the risk of worsening renal function. Copyright © 2016 Elsevier Inc. All rights reserved.

Progress of the ECRH Upper Launcher design for ITER

International Nuclear Information System (INIS)

Strauss, D.; Aiello, G.; Bruschi, A.; Chavan, R.; Farina, D.; Figini, L.; Gagliardi, M.; Garcia, V.; Goodman, T.P.; Grossetti, G.; Heemskerk, C.; Henderson, M.A.; Kasparek, W.; Krause, A.; Landis, J.-D.; Meier, A.; Moro, A.; Platania, P.; Plaum, B.; Poli, E.

2014-01-01

The design of the ITER ECRH system provides 20 MW millimeter wave power for central plasma heating and MHD stabilization. The system consists of an array of 24 gyrotrons with power supplies coupled to a set of transmission lines guiding the beams to the four upper and the equatorial launcher. The front steering upper launcher design described herein has passed successfully the preliminary design review, and it is presently in the final design stage. The launcher consists of a millimeter wave system and steering mechanism with neutron shielding integrated into an upper port plug with the plasma facing blanket shield module (in-vessel) and a set of ex-vessel waveguides connecting the launcher to the transmission lines. Part of the transmission lines are the ultra-low loss CVD torus diamond windows and a shutter valve, a miter bend section and the feedthroughs integrated in the plug closure plate. These components are connected by corrugated waveguides and form together the first confinement system (FCS). In-vessel, the millimeter-wave system includes a quasi-optical beam propagation system including four mirror sets and a front steering mirror. The millimeter wave system is integrated into a specifically optimized upper port plug providing structural stability to withstand plasma disruption forces and the high heat load from the plasma side with a dedicated blanket shield module. A recent update in the ITER interface definition has resulted in the recession of the upper port plug first wall panels, which is now integrated into the design. Apart from the millimeter wave system the upper port plug houses also a set of shield blocks which provide neutron shielding. An overview of the actual ITER ECRH Upper Launcher is given together with some highlights of the design

Advances in laser solenoid fusion reactor design

International Nuclear Information System (INIS)

Steinhauer, L.C.; Quimby, D.C.

1978-01-01

The laser solenoid is an alternate fusion concept based on a laser-heated magnetically-confined plasma column. The reactor concept has evolved in several systems studies over the last five years. We describe recent advances in the plasma physics and technology of laser-plasma coupling. The technology advances include progress on first walls, inner magnet design, confinement module design, and reactor maintenance. We also describe a new generation of laser solenoid fusion and fusion-fission reactor designs

New imaging systems in nuclear medicine. Technical progress report, July 1, 1975--March 15, 1976

International Nuclear Information System (INIS)

Brownell, G.L.

1976-01-01

This progress report covers four areas: development of positron instrumentation, development of NUMEDICS computer system and software, application of cyclotron-produced isotopes ( 11 C, 68 Ga, 13 N, 15 O, and 82 Rb), and application of the NUMEDICS computer system in nuclear medicine. The development of transverse section positron imaging has had a significant impact and a positron camera was designed specifically for transverse section imaging of heart and lungs. The computer net (NUMEDICS II) is progressing rapidly in design and software development. Clinical studies have demonstrated the feasibility of measuring cerebral blood flow using a variety of positron emitting radiopharmaceuticals and oxygen utilization using 15 O 2 . Rubidium-82 also appears to be a promising agent for measurement of cerebral blood flow

Considering RNAi experimental design in parasitic helminths.

Science.gov (United States)

Dalzell, Johnathan J; Warnock, Neil D; McVeigh, Paul; Marks, Nikki J; Mousley, Angela; Atkinson, Louise; Maule, Aaron G

2012-04-01

Almost a decade has passed since the first report of RNA interference (RNAi) in a parasitic helminth. Whilst much progress has been made with RNAi informing gene function studies in disparate nematode and flatworm parasites, substantial and seemingly prohibitive difficulties have been encountered in some species, hindering progress. An appraisal of current practices, trends and ideals of RNAi experimental design in parasitic helminths is both timely and necessary for a number of reasons: firstly, the increasing availability of parasitic helminth genome/transcriptome resources means there is a growing need for gene function tools such as RNAi; secondly, fundamental differences and unique challenges exist for parasite species which do not apply to model organisms; thirdly, the inherent variation in experimental design, and reported difficulties with reproducibility undermine confidence. Ideally, RNAi studies of gene function should adopt standardised experimental design to aid reproducibility, interpretation and comparative analyses. Although the huge variations in parasite biology and experimental endpoints make RNAi experimental design standardization difficult or impractical, we must strive to validate RNAi experimentation in helminth parasites. To aid this process we identify multiple approaches to RNAi experimental validation and highlight those which we deem to be critical for gene function studies in helminth parasites.

Progress Report 2013. Turnaround Arts Initiative

Science.gov (United States)

Stoelinga, Sara Ray; Joyce, Katie; Silk, Yael

2013-01-01

This interim progress report provides a look at Turnaround Arts schools in their first year, including: (1) a summary of the evaluation design and research questions; (2) a preliminary description of strategies used to introduce the arts in Turnaround Arts schools; and (3) a summary of school reform indicators and student achievement data at…

Engineering and licensing progress of the HTR-Module

Energy Technology Data Exchange (ETDEWEB)

Weisbrodt, I A

1988-07-01

This report deals not only with the latest status of Siemens/Interatom's HTR-Module but also reflects the latest engineering and licensing progress of the HTR-Module against the background of the specified design requirements and of the discussions on passively safe reactors. Therefore, I intend to report also about two examples of the accident analysis - one design basis accident, i.e. the leak-before-break of the reactor pressure vessel and one beyond design accident, i. e. massive water ingress.

Engineering and licensing progress of the HTR-Module

International Nuclear Information System (INIS)

Weisbrodt, I.A.

1988-01-01

This report deals not only with the latest status of Siemens/Interatom's HTR-Module but also reflects the latest engineering and licensing progress of the HTR-Module against the background of the specified design requirements and of the discussions on passively safe reactors. Therefore, I intend to report also about two examples of the accident analysis - one design basis accident, i.e. the leak-before-break of the reactor pressure vessel and one beyond design accident, i. e. massive water ingress

Sex differences in progression to mild cognitive impairment and dementia in Parkinson's disease.

Science.gov (United States)

Cholerton, Brenna; Johnson, Catherine O; Fish, Brian; Quinn, Joseph F; Chung, Kathryn A; Peterson-Hiller, Amie L; Rosenthal, Liana S; Dawson, Ted M; Albert, Marilyn S; Hu, Shu-Ching; Mata, Ignacio F; Leverenz, James B; Poston, Kathleen L; Montine, Thomas J; Zabetian, Cyrus P; Edwards, Karen L

2018-05-01

Identification of factors associated with progression of cognitive symptoms in Parkinson's disease (PD) is important for treatment planning, clinical care, and design of future clinical trials. The current study sought to identify whether prediction of cognitive progression is aided by examining baseline cognitive features, and whether this differs according to stage of cognitive disease. Participants with PD in the Pacific Udall Center Clinical Consortium who had longitudinal data available and were nondemented at baseline were included in the study (n = 418). Logistic and Cox regression models were utilized to examine the relationship between cognitive, demographic, and clinical variables with risk and time to progression from no cognitive impairment to mild cognitive impairment (PD-MCI) or dementia (PDD), and from PD-MCI to PDD. Processing speed (OR = 1.05, p = 0.009) and working memory (OR = 1.01, p = 0.03) were associated with conversion to PDD among those with PD-MCI at baseline, over and above demographic variables. Conversely, the primary predictive factor in the transition from no cognitive impairment to PD-MCI or PDD was male sex (OR = 4.47, p = 0.004), and males progressed more rapidly than females (p = 0.01). Further, among females with shorter disease duration, progression was slower than for their male counterparts, and poor baseline performance on semantic verbal fluency was associated with shorter time to cognitive impairment in females but not in males. This study provides evidence for sex differences in the progression to cognitive impairment in PD, while specific cognitive features become more important indicators of progression with impending conversion to PDD. Copyright © 2018 Elsevier Ltd. All rights reserved.

Five-year progression of unilateral age-related macular degeneration to bilateral involvement: the Three Continent AMD Consortium report

NARCIS (Netherlands)

Joachim, N.; Colijn, J.M.; Kifley, A.; Lee, K.E.; Buitendijk, G.H.; Klein, B.E.; Myers, C.E.; Meuer, S.M.; Tan, A.G.; Holliday, E.G.; Attia, J.; Liew, G.; Iyengar, S.K.; Jong, p de; Hofman, A.; Vingerling, J.R.; Mitchell, P.; Klaver, C.C.W.; Klein, R.; Wang, J.J.

2017-01-01

PURPOSE: To assess the 5-year progression from unilateral to bilateral age-related macular degeneration (AMD) and associated risk factors. DESIGN: Pooled data analyses of three prospective population-based cohorts, the Blue Mountains Eye Study, Beaver Dam Eye Study and Rotterdam Study. METHODS:

Five-year progression of unilateral age-related macular degeneration to bilateral involvement : the Three Continent AMD Consortium report

NARCIS (Netherlands)

Joachim, Nichole; Colijn, Johanna Maria; Kifley, Annette; Lee, Kristine E; Buitendijk, Gabriëlle H S; Klein, Barbara E K; Myers, Chelsea E; Meuer, Stacy M; Tan, Ava G; Holliday, Elizabeth G; Attia, John; Liew, Gerald; Iyengar, Sudha K; de Jong, Paulus T V M; Hofman, Albert; Vingerling, Johannes R; Mitchell, Paul; Klaver, Caroline C W; Klein, Ronald; Wang, Jie Jin

2017-01-01

PURPOSE: To assess the 5-year progression from unilateral to bilateral age-related macular degeneration (AMD) and associated risk factors. DESIGN: Pooled data analyses of three prospective population-based cohorts, the Blue Mountains Eye Study, Beaver Dam Eye Study and Rotterdam Study. METHODS:

Incidence and progression of myopia and associated factors in urban school children in Delhi: The North India Myopia Study (NIM Study.

Directory of Open Access Journals (Sweden)

Rohit Saxena

Full Text Available To evaluate the incidence and progression of myopia and factors associated with progression of myopia in school going children in Delhi.Prospective longitudinal study of 10,000 school children aged 5 to 15 years screened after an interval of 1 year to identify new myopes (Spherical Equivalent≤ -0.5D and progression of myopia in previously diagnosed myopic children. Association between risk factors and progression was analyzed using adjusted odds ratio.Of the 9,616 children re-screened (97.3% coverage, annual incidence of myopia was 3.4%with mean dioptric change of -1.09 ± 0.55. There was a significant higher incidence of myopia in younger children compared to older children (P = 0.012 and among girls compared to boys (P = 0.002. Progression was observed in 49.2%children with mean dioptric change of -0.27 ± 0.42 diopters. The demographic and behavioral risk factors were analyzed for children with progression (n = 629 and adjusted odds ratio values were estimated. Hours of reading-writing/week (p 2 hours in a day were protective with an inverse association with progression of myopia (P< 0.001.Myopia is an important health issue in India and is associated with long hours of reading and screen time with use of computers and video games. An annual eye vision screening should be conducted, and outdoor activities be promoted to prevent the increase of myopia among school children.

Site characterization progress report, April 1, 1994--September 30, 1994: Yucca Mountain, Nevada. Volume 11

International Nuclear Information System (INIS)

1995-03-01

The Civil Radioactive Waste Management Program was restructured to provide a new approach to the evaluation of the site for development as a repository and to its licensing. Funding was increased for FY 95, with most of the increase going to the Yucca Mountain site characterization project. During this period, significant progress was made in surface-based testing, advanced conceptual design, performance assessment, planning, licensing support system development activities, and construction of the Exploratory Studies Facility. The report is divided into the following sections: introduction, programmatic activities, site programs, repository design, waste package, performance assessment, and exploratory studies facility design/construction

Maryland University sectored isochronous cyclotron (MUSIC): Progress report No. 14

Energy Technology Data Exchange (ETDEWEB)

1967-01-10

The past quarter has seen further progress in the solution of the problem of achieving a cyclotron which meets or exceeds the performance requirements. The magnet system, with the exception of the trim coils and their supplies, is all on order or about to be ordered, and a high confidence level exists that the system will meet all requirements. The rf system studies, nearly complete, have indicated that the solution chosen will meet the frequency requirements and will be within the power expected. The center studies, complete in the first phase, have resulted in a preliminary center design of the electrostatic focusing system and a design of the magnetic center which provides the required axial focusing. A high degree of cooperation on the center study programs between the U of M and CSF has efficiently yielded these results. The overall schedule continues to be maintained, and the program is expected to be completed on the 37-month schedule. For better control and greater visibility on schedule progress, two reference points have been selected as more immediate objectives. These are 17 July 1967 for the start of the magnet testing program and 2 October 1967 as the start of the rf high power tests. Each task involved is being analyzed with these dates in mind, and they appear to be reasonable.

Recent progress of neuroimaging studies on sleeping brain

International Nuclear Information System (INIS)

Sasaki, Yuka

2012-01-01

Although sleep is a familiar phenomenon, its functions are yet to be elucidated. Understanding these functions of sleep is an important focus area in neuroscience. Electroencephalography (EEG) has been the predominantly used method in human sleep research but does not provide detailed spatial information about brain activation during sleep. To supplement the spatial information provided by this method, researchers have started using a combination of EEG and various advanced neuroimaging techniques that have been recently developed, including positron emission tomography (PET) and magnetic resonance imaging (MRI). In this paper, we will review the recent progress in sleep studies, especially studies that have used such advanced neuroimaging techniques. First, we will briefly introduce several neuroimaging techniques available for use in sleep studies. Next, we will review the spatiotemporal brain activation patterns during non-rapid eye movement (NREM) and rapid eye movement (REM) sleep, the dynamics of functional connectivity during sleep, and the consolidation of learning and memory during sleep; studies on the neural correlates of dreams, which have not yet been identified, will also be discussed. Lastly, possible directions for future research in this area will be discussed. (author)

[Recent progress of neuroimaging studies on sleeping brain].

Science.gov (United States)

Sasaki, Yuka

2012-06-01

Although sleep is a familiar phenomenon, its functions are yet to be elucidated. Understanding these functions of sleep is an important focus area in neuroscience. Electroencephalography (EEG) has been the predominantly used method in human sleep research but does not provide detailed spatial information about brain activation during sleep. To supplement the spatial information provided by this method, researchers have started using a combination of EEG and various advanced neuroimaging techniques that have been recently developed, including positron emission tomography (PET) and magnetic resonance imaging (MRI). In this paper, we will review the recent progress in sleep studies, especially studies that have used such advanced neuroimaging techniques. First, we will briefly introduce several neuroimaging techniques available for use in sleep studies. Next, we will review the spatiotemporal brain activation patterns during non-rapid eye movement (NREM) and rapid eye movement (REM) sleep, the dynamics of functional connectivity during sleep, and the consolidation of learning and memory during sleep; studies on the neural correlates of dreams, which have not yet been identified, will also be discussed. Lastly, possible directions for future research in this area will be discussed.

Progression and regression of atherosclerosis in APOE3-Leiden transgenic mice : An immunohistochemical study

NARCIS (Netherlands)

Gijbels, M.J.J.; Cammen, M. van der; Laan, L.J.W. van der; Emeis, J.J.; Havekes, L.M.; Hofker, M.H.; Kraal, G.

1999-01-01

Apolipoprotein E3-Leiden (APOE3-Leiden) transgenic mice develop hyperlipidemia and are highly susceptible to diet-induced atherosclerosis. We have studied the progression and regression of atherosclerosis using immunohistochemistry. Female transgenic mice were fed a moderate fat diet to study

Developmental Progression of Looking and Reaching Performance on the A-Not-B Task

Science.gov (United States)

Cuevas, Kimberly; Bell, Martha Ann

2010-01-01

From a neuropsychological perspective, the cognitive skills of working memory, inhibition, and attention and the maturation of the frontal lobe are requisites for successful A-not-B performance on both the looking and reaching versions of the task. This study used a longitudinal design to examine the developmental progression of infants'…

A review on progress of man-machine interface system designs for Japanese PWRs

International Nuclear Information System (INIS)

Yoshikawa, Hidekazu; Yamamoto, Yoshihiro; Magari, Takayuki.

1994-01-01

Historical development of Instrumentation and Control (I and C) system designing for the PWR plants in Kansai Electric Co. Ltd is firstly reviewed with respect to the conventional PWRs in the past, brand-new PWRs (Ohi 3/4 units) and advanced PWRs (APWR) in Japan. The major features of the APWR I and C system design are extensive application of digital computer control technology and advanced man-machine interface in order to enhance safety and reliability of total I and C system and to improve human factors in nuclear power plant operation. Comparative study of the APWR's I and C system design with the EPRI's User Requirement Definitions (URD) resulted in that the current Japanese APWR I and C system design meets generally with the EPRI URD conditions except for those items mainly set by the present national regulatory guidelines. The remaining problems in the current I and C system design are discussed which include the issues on future direction of man-machine interface development. (author)

Chemistry Division: progress report (1983-84)

International Nuclear Information System (INIS)

Shastri, L.V.; George, A.M.

1985-01-01

This is the seventh progress report of the Chemistry Division covering the two years 1983 and 1984. The main emphasis of the Division continues to be on basic research though spin offs in high technology areas are closely pursued. Laboratory facilities have been considerably augmented during this period. Besides the design and fabrication of a crossed molecular beam chemiluminescence apparatus, a 80 MHz FTNMR and a 5nsec. excimer laser kinetic spectrometer were acquired; a 5nsec. pulsed electron accelerator would be installed in 1985. The research and development projects taken up during the VI Five Year Plan have achieved considerable progress. Only brief accounts of investigations are presented in the report. (author)

Studies in iodine metabolism. Progress report, 1982-1983

International Nuclear Information System (INIS)

Van Middlesworth, L.

1983-01-01

Research progress is reported for the period 1982 to 1983 in the following areas: (1) monitoring of animal thyroids for 129 I, 125 I, 131 I, 226 Ra, and 228 Ra; and (2) neonatal hypo-l thyroidism in laboratory rats

Progressive resistance training in head and neck cancer patients during concomitant chemoradiotherapy -- design of the DAHANCA 31 randomized trial

DEFF Research Database (Denmark)

Lonkvist, Camilla K; Lønbro, Simon; Vinther, Anders

2017-01-01

. This randomized study investigates whether progressive resistance training (PRT) may attenuate loss of muscle mass and functional performance. Furthermore, biochemical markers and muscle biopsies will be investigated trying to link biological mechanisms to training effects. METHODS: At the Departments of Oncology...... content in muscles, as well as muscle fiber type and fiber size in muscle biopsies. Muscle biopsies are optional. DISCUSSION: This randomized study investigates the impact of a 12-week progressive resistance training program on lean body mass and several other physiological endpoints, as well as impact...... on adverse events and quality of life. Furthermore, a translational approach is integrated with extensive biological sampling and exploration into cytokines and mechanisms involved. The current paper discusses decisions and methods behind exercise in head and neck cancer patients undergoing concomitant...

2004 Progress Report

Energy Technology Data Exchange (ETDEWEB)

Batistoni, Paola; De Marco, Francesco; Pieroni, Leonardo [ed.

2005-07-01

Fusion research is undertaken all over the world with the objective of realising an environmentally responsible source of energy with essentially unlimited and widely distributed fuel reserves. The results of the worldwide efforts made in recent years are now embodied in ITER, the International Thermonuclear Experimental Reactor, designed to produce at least 500 MW of fusion power with a power gain of ten. ITER will test for the first time the interaction of fusion plasma physics with power station technology. In this international framework, during 2004 Fusion Technical and Scientific Unit of ENEA obtained important results in several keys areas. At the Frascati Tokamak Upgrade the lower hybrid microwave system was fully exploited to study the generation and control of the plasma current, and the electron cyclotron heating system reached full power (1.5 MW). With the simultaneous injection of the two waves, good energy confinement regimes with internal transport barriers were obtained at the highest plasma densities ever achieved. Advanced scenario regimes were also addressed in the activities of ENEA at JET. The engineering design of the IGNITOR machine was finalised, and significant progress was made in understanding the plasma physics regimes. Among the technology activities, the qualification of the deposition process of a copper liner on carbon fibre composite (CFC) hollow tiles may be mentioned as the most important achievement. This innovative pre brazed casting process is a competitive candidate for the fabrication of the CFCbased ITER divertor components. ENEA participated in the European activity for the definition and production on an industrial scale of an advanced Nb3Sn strand for the ITER superconducting central solenoid and toroidal field coils. Contributions were also made to the design of the final conductor layout and the characterisation tests. Inertial fusion studies continued along the previous lines, namely, the study of the implosion

2004 Progress Report

International Nuclear Information System (INIS)

Batistoni, Paola; De Marco, Francesco; Pieroni, Leonardo

2005-01-01

Fusion research is undertaken all over the world with the objective of realising an environmentally responsible source of energy with essentially unlimited and widely distributed fuel reserves. The results of the worldwide efforts made in recent years are now embodied in ITER, the International Thermonuclear Experimental Reactor, designed to produce at least 500 MW of fusion power with a power gain of ten. ITER will test for the first time the interaction of fusion plasma physics with power station technology. In this international framework, during 2004 Fusion Technical and Scientific Unit of ENEA obtained important results in several keys areas. At the Frascati Tokamak Upgrade the lower hybrid microwave system was fully exploited to study the generation and control of the plasma current, and the electron cyclotron heating system reached full power (1.5 MW). With the simultaneous injection of the two waves, good energy confinement regimes with internal transport barriers were obtained at the highest plasma densities ever achieved. Advanced scenario regimes were also addressed in the activities of ENEA at JET. The engineering design of the IGNITOR machine was finalised, and significant progress was made in understanding the plasma physics regimes. Among the technology activities, the qualification of the deposition process of a copper liner on carbon fibre composite (CFC) hollow tiles may be mentioned as the most important achievement. This innovative pre brazed casting process is a competitive candidate for the fabrication of the CFCbased ITER divertor components. ENEA participated in the European activity for the definition and production on an industrial scale of an advanced Nb3Sn strand for the ITER superconducting central solenoid and toroidal field coils. Contributions were also made to the design of the final conductor layout and the characterisation tests. Inertial fusion studies continued along the previous lines, namely, the study of the implosion

Progress Toward NLC/GLC Prototype Accelerator Structures

International Nuclear Information System (INIS)

Wang, J

2004-01-01

The accelerator structure groups for NLC (Next Linear Collider) and GLC (Global Linear Colliders) have successfully collaborated on the research and development of a major series of advanced accelerator structures based on room-temperature technology at X-band frequency. The progress in design, simulation, microwave measurement and high gradient tests are summarized in this paper. The recent effort in design and fabrication of the accelerator structure prototype for the main linac is presented in detail including HOM (High Order Mode) suppression and design of HOM couplers and fundamental mode couplers, optimized accelerator cavities as well as plans for future structures

HSX progress report

International Nuclear Information System (INIS)

1994-01-01

Brief statements on the progress of the design and construction of the HSX experiment are reported. Topics covered include the modular and auxiliary coil systems, the coil support structure, vacuum vessel, the ECH system, the magnet power supply and site. The proposed budget for Year 2 (August 1, 1994 through July 31, 1995) is presented. The effects of a flat funding profile (based on Year 2 budget level of $1137K) on out-years and the HSX project schedule are discussed. The stretching out of the program to accommodate the reduced funding profile should result in only a slight delay in HSX operations

Flat-plate solar array progress and plans

Science.gov (United States)

Callaghan, W. T.; Henry, P. K.

1984-01-01

The Flat-Plate Solar Array Project (FSA), sponsored by the U.S. Department of Energy (DOE) and managed by the Jet Propulsion Laboratory (JPL), has achieved progress in a broad range of technical activities since that reported at the Fourth European Communities Conference. A particularly important analysis has been completed recently which confirms the adoption into practice by the U.S. Photovoltaic (PV Industry, of all the low-cost module technology elements proposed at the 16th Project Integration Meeting for a $2.80/Wp (1980 U.S. Dollars) design approach in the fall of 1980. This work presents along with a projection, using the same techniques, for what is believed to be a very credible ribbon-based module design for less that $0.55/Wp (1980 U.S. Dollars). Other areas to be reported upon include low-cost Si feedstock refinement; ribbon growth; process sequence development for cells; environmental isolation; engineering science investigations; and module testing progress.

Undergraduate Use of Library Databases Decreases as Level of Study Progresses

Directory of Open Access Journals (Sweden)

Kimberly Miller

2014-09-01

Full Text Available A Review of: Mbabu, L.G., Bertram, A. B., & Varnum, K. (2013. Patterns of undergraduates’ use of scholarly databases in a large research university. Journal of Academic Librarianship, 39(2, 189-193. http://dx.doi.org/10.10.1016/j.acalib.2012.10.004 Abstract Objective – To investigate undergraduate students’ patterns of electronic database use to discover whether database use increases as undergraduate students progress into later stages of study with increasingly sophisticated information needs and demands. Design – User database authentication log analysis. Setting – A large research university in the Midwestern United States of America. Subjects – A total of 26,208 undergraduate students enrolled during the Fall 2009 academic semester. Methods – The researchers obtained logs of user-authenticated activity from the university’s databases. Logged data for each user included: the user’s action and details of that action (including database searches, the time of action, the user’s relationship to the university, the individual school in which the user was enrolled, and the user’s class standing. The data were analyzed to determine which proportion of undergraduate students accessed the library’s electronic databases. The study reports that the logged data accounted for 61% of all database activity, and the authors suggest the other 39% of use is likely from “non-undergraduate members of the research community within the [university’s] campus IP range” (192. Main Results – The study found that 10,897 (42% of the subject population of undergraduate students accessed the library’s electronic databases. The study also compared database access by class standing, and found that freshman undergraduates had the highest proportion of database use, with 56% of enrolled freshman accessing the library’s databases. Sophomores had the second highest proportion of students accessing the databases at 40%; juniors and seniors

Five-year progression of unilateral age-related macular degeneration to bilateral involvement: the Three Continent AMD Consortium report

NARCIS (Netherlands)

Joachim, Nichole; Colijn, Johanna Maria; Kifley, Annette; Lee, Kristine E.; Buitendijk, Gabriëlle H. S.; Klein, Barbara E. K.; Myers, Chelsea E.; Meuer, Stacy M.; Tan, Ava G.; Holliday, Elizabeth G.; Attia, John; Liew, Gerald; Iyengar, Sudha K.; de Jong, Paulus T. V. M.; Hofman, Albert; Vingerling, Johannes R.; Mitchell, Paul; Klaver, Caroline C. W.; Klein, Ronald; Wang, Jie Jin

2017-01-01

Purpose To assess the 5-year progression from unilateral to bilateral age-related macular degeneration (AMD) and associated risk factors. Design Pooled data analyses of three prospective population-based cohorts, the Blue Mountains Eye Study, Beaver Dam Eye Study and Rotterdam Study. Methods Retinal

Research by design: honouring the Stolen Generation a theoretical anti-memorial

OpenAIRE

Sue-Anne Ware

1999-01-01

This paper discusses theoretical design frameworks and research methods for contemporary memorial design. It is a case study for research by design, an expanding area of design discourse, which offers an alternative to quantitative research practices and 'scientific' methodologies. It expands upon a design research studio, which explored formal design outcomes for an anti-memorial to The Stolen Generation. This essay focuses on ideas about progressive memorial design which prompts multiple re...

Inertial fusion program. Progress report, July 1-December 31, 1978

International Nuclear Information System (INIS)

Perkins, R.B.

1980-11-01

Progress at Los Alamos Scientific Laboratory (LASL) in the development of high-energy short-pulse CO 2 laser systems for fusion research is reported. Improvements to LASL's two-beam system, Gemini, are outlined and experimental results are discussed. Our eight-beam system, Helios, was fired successfully on target for the first time, and became the world's most powerful gas laser for laser fusion studies. Work on Antares, our 100- to 200-TW target irradiation system, is summarized, indicating that design work and building construction are 70 and 48% complete, respectively. A baseline design for automatic centering of laser beams onto the various relay mirrors and the optical design of the Antares front end are discussed. The results of various fusion reactor studies are summarized, as well as investigations of synthetic-fuel production through application of fusion energy to hydrogen production by thermochemical water splitting. Studies on increased efficiency of energy extraction in CO 2 lasers and on lifetimes of cryogenic pellets in a reactor environment are summarized, as well as the results of studies on pellet injection, tracking, and beam synchronization

Design study of superconducting coils for the fusion DEMO plant at JAERI

International Nuclear Information System (INIS)

Isono, T.; Koizumi, N.; Okuno, K.; Kurihara, R.; Nishio, S.; Tobita, K.

2006-01-01

A design study of the TF coil for the fusion DEMO plant at JAERI is in progress. A major issue is to estimate the maximum fields generated by the TF coils for three tokamak options and two conductor options. Three tokamak options are proposed varying the aspect ratio and the role of the CS coil. Two kinds of conductors using advanced superconducting materials are candidates for the TF coils: Nb 3 Al and high temperature superconductor (HTS). In order to evaluate achievable magnetic fields, a simple method was adopted to calculate mechanical properties. The estimated maximum fields are 17-20 T by the HTS conductor and 16-17 T by the Nb 3 Al conductor. There is a possibility of a 0.7 T enhancement using grading of Nb 3 Al winding

Key features and progress of the KSTAR tokamak engineering

International Nuclear Information System (INIS)

Bak, J.S.; Choi, C.H.; Oh, Y.K.

2003-01-01

Substantial progress of the KSTAR tokamak engineering has been made on major tokamak structures, superconducting magnets, in-vessel components, diagnostic system, heating system, and power supplies. The engineering design has been elaborated to the extent necessary to allow a realistic assessment of its feasibility, performance, and cost. The prototype fabrication has been carried out to establish the reliable fabrication technologies and to confirm the validation of analyses employed for the KSTAR design. The completion of experimental building with beneficial occupancy for machine assembly was accomplished in Sep. 2002. The construction of special utility such as cryo-plant, de-ionized water-cooling system, and main power station will begin upon completion of building construction. The commissioning, construction, fabrication, and assembly of the whole facility will be going on by the end of 2005. This paper describes the main design features and engineering progress of the KSTAR tokamak, and elaborates the work currently underway. (author)

Progress report on nuclear spectroscopic studies, June 1, 1977--May 31, 1978

International Nuclear Information System (INIS)

Bingham, C.R.; Riedinger, L.L.; Guidry, M.W.

1978-01-01

Research progress is summarized for activities of the University of Tennessee department of physics and astronomy in the following areas: (1) in-beam spectroscopy of high-spin state, (2) Coulomb-nuclear interference and inelastic heavy ion scattering (3) Coulomb excitation, nuclear theory, (4) nuclear structure studies with alpha-induced direct reactions, and (5) developmental activities

FY 2017-Progress Report on the Design and Construction of the Sodium Loop SMT-3

Energy Technology Data Exchange (ETDEWEB)

Natesan, K. [Argonne National Lab. (ANL), Argonne, IL (United States); Momozaki, Y. [Argonne National Lab. (ANL), Argonne, IL (United States)

2017-09-01

information is being transmitted to the tank fabricator. The SMT-3 loop will be located in Building 206 adjacent to the currently operating SMT-2 loop. In addition, we have demolished the aged power supply system in Building 206 and installed a new transformer, wiring, and power panels for the new loop. Procurement of some of the long lead items such as valves, EM pumps, EM flowmeters, etc. is in progress and will continue in FY 2018. The construction of components such as cold trap, economizers, piping arrangement etc. will be performed in the central shops at ANL. About 150 liters of sodium for the loop will be procured in early FY2018. The loop system is designed to circulate sodium through the sample tanks and the associated loop without an operator for an extended period of time. With the three sodium loops (with single-tank, dual-tank and four–tanks), materials can be tested at different sodium temperatures, and large tensile, creep, fatigue, creep-fatigue, and fracture toughness specimens can be exposed to sodium for extended periods of time and generate data on mechanical properties in support of ASME Code Qualification and USNRC Licensing of advanced Alloy 709 for use as a structural material in SFRs.

Study designs may influence results

DEFF Research Database (Denmark)

Johansen, Christoffer; Schüz, Joachim; Andreasen, Anne-Marie Serena

2017-01-01

appeared to show an inverse association, whereas nested case-control and cohort studies showed no association. For allergies, the inverse association was observed irrespective of study design. We recommend that the questionnaire-based case-control design be placed lower in the hierarchy of studies...... for establishing cause-and-effect for diseases such as glioma. We suggest that a state-of-the-art case-control study should, as a minimum, be accompanied by extensive validation of the exposure assessment methods and the representativeness of the study sample with regard to the exposures of interest. Otherwise...

Progress in the development of methodology for fusion safety systems studies

International Nuclear Information System (INIS)

Ho, S.K.; Cambi, G.; Ciattaglia, S.; Fujii-e, Y.; Seki, Y.

1994-01-01

The development of fusion safety systems-study methodology, including the aspects of schematic classification of overall fusion safety system, qualitative assessment of fusion system for identification of critical accident scenarios, quantitative analysis of accident consequences and risk for safety design evaluation, and system-level analysis of accident consequences and risk for design optimization, by a consortium of international efforts is presented. The potential application of this methodology into reactor design studies will facilitate the systematic assessment of safety performance of reactor designs and enhance the impacts of safety considerations on the selection of design configurations

Treatment Beyond Progression in Patients with Advanced Renal Cell Carcinoma Treated with Nivolumab in CheckMate 025

DEFF Research Database (Denmark)

Escudier, Bernard; Motzer, Robert J; Sharma, Padmanee

2017-01-01

BACKGROUND: Response patterns to nivolumab differ from those seen with other approved targeted therapies. OBJECTIVE: To investigate the efficacy of nivolumab in previously treated patients with advanced renal cell carcinoma who were treated beyond (Response Evaluation Criteria In Solid Tumors......) RECIST progression. DESIGN, SETTING, AND PARTICIPANTS: This was a subgroup analysis of patients treated with nivolumab in the phase 3 CheckMate 025 study. Patients continuing to tolerate therapy and exhibiting investigator-assessed clinical benefit were eligible to be treated beyond RECIST progression...... (TBP) and received therapy for ≥4 wk after first progression; patients not treated beyond RECIST progression (NTBP) received 0 wk to Nivolumab 3mg/kg intravenously every 2 wk. RESULTS AND LIMITATIONS: Of 406 nivolumab-treated patients, 316 (78...

SPFC bus design studies

Energy Technology Data Exchange (ETDEWEB)

Potter, L.; Reinkingh, J.

1999-07-01

This report presents the results of a study assessing the design options for a solid polymer fuel cell bus. Commercial and operation requirements, environmental and market drivers, and fuel processor modeling are examined. Power train specifications and detailed system design are investigated covering fuel cell system dynamic response, hybrid system size, fuel cell system start-up time, system specifications, and hybrid bus component dimensions and costs. (UK)

The Waste Treatment Plant, a Work in Progress

International Nuclear Information System (INIS)

Hamel, W. F. Jr.; Duncan, G. M.

2006-01-01

There are many challenges in the design and construction of Department of Energy's (DOE) Waste Treatment and Immobilization Plant (WTP) at the Hanford site. The plant is being built to process some 55 million gallons of radioactive waste from 177 underground tanks. Engineering and construction are progressing on this largest project in the DOE complex. This paper describes some of WTP's principal recent challenges and opportunities and how they are being addressed to minimize impact on the project, enhance the capabilities of the facilities, and reduce risk. A significant new development in 2005 was the need to account for higher seismic accelerations than originally specified for the facility structures and equipment. Efforts have centered on continuing design and construction with minimal risk, while the final seismic design spectra was developed. Other challenges include development of an alternative cesium ion exchange resin to minimize the risk from reliance on a single product, implementing advanced analytical techniques to improve laboratory performance, adopting a thinner walled high level waste (HLW) canister to reduce waste volume and mission duration, and commissioning a comprehensive external flowsheet review of the design, along with its underpinning technologies, and projected plant operability. These challenges make it clear that WTP is a work in progress, but the challenges are being successfully resolved as the design and construction move on to completion. (authors)

The population-based Barcelona-Asymptomatic Intracranial Atherosclerosis Study (ASIA: rationale and design

Directory of Open Access Journals (Sweden)

Pera Guillem

2011-02-01

Full Text Available Abstract Background Large-artery intracranial atherosclerosis may be the most frequent cause of ischemic stroke worldwide. Traditional approaches have attempted to target the disease when it is already symptomatic. However, early detection of intracranial atherosclerosis may allow therapeutic intervention while the disease is still asymptomatic. The prevalence and natural history of asymptomatic intracranial atherosclerosis in Caucasians remain unclear. The aims of the Barcelona-ASymptomatic Intracranial Atherosclerosis (ASIA study are (1 to determine the prevalence of ASIA in a moderate-high vascular risk population, (2 to study its prognostic impact on the risk of suffering future major ischemic events, and (3 to identify predictors of the development, progression and clinical expression of this condition. Methods/Design Cross-over and cohort, population-based study. A randomly selected representative sample of 1,503 subjects with a mild-moderate-high vascular risk (as defined by a REGICOR score ≥ 5% and with neither a history of cerebrovascular nor ischemic heart disease will be studied. At baseline, all individuals will undergo extracranial and transcranial Color-Coded Duplex (TCCD ultrasound examinations to detect presence and severity of extra and intracranial atherosclerosis. Intracranial stenoses will be assessed by magnetic resonance angiography (MRA. Clinical and demographic variables will be recorded and blood samples will be drawn to investigate clinical, biological and genetic factors associated with the presence of ASIA. A long-term clinical and sonographic follow-up will be conducted thereafter to identify predictors of disease progression and of incident vascular events. Discussion The Barcelona-ASIA is a population-based study aiming to evaluate the prevalence and clinical importance of asymptomatic intracranial large-artery atherosclerosis in Caucasians. The ASIA project may provide a unique scientific resource to better

Designing with LED

OpenAIRE

Johnson, Amanda

2018-01-01

This presentation focuses on the recently adopted changes in the way highway lighting systems are designed, with emphasis on how the approved list of solid state–based luminaires is integrated into the design process. Progress made on the approved list and experiences in developing it will also be shared.

Collective design in 3D printing: A large scale empirical study of designs, designers and evolution

DEFF Research Database (Denmark)

Özkil, Ali Gürcan

2017-01-01

This paper provides an empirical study of a collective design platform (Thingiverse); with the aim of understanding the phenomenon and investigating how designs concurrently evolve through the large and complex network of designers. The case study is based on the meta-data collected from 158 489 ...

Development of a competency-based formative progress test with student-generated MCQs: Results from a multi-centre pilot study

Directory of Open Access Journals (Sweden)

Wagener, Stefan

2015-10-01

Full Text Available Introduction: Progress tests provide students feedback on their level of proficiency over the course of their medical studies. Peer-assisted learning and competency-based education have become increasingly important in medical education. Although progress tests have been proven to be useful as a longitudinal feedback instrument, there are currently no progress tests that have been created in cooperation with students or that focus on competency in medical education.In this study, we investigated the extent to which students can be included in the development of a progress test and demonstrated that aspects of knowledge related to competency can be represented on a competency-based progress test.Methods: A two-dimensional blueprint for 144 multiple-choice questions (MCQs covering groups of medical subjects and groups of competency areas was generated by three expert groups for developing the competency-based progress test. A total of 31 students from seven medical schools in Germany actively participated in this exercise. After completing an intensive and comprehensive training programme, the students generated and reviewed the test questions for the competency-based progress test using a separate platform of the ItemManagementSystem (IMS. This test was administered as a formative test to 469 students in a pilot study in November 2013 at eight medical schools in Germany. The scores were analysed for the overall test and differentiated according to the subject groups and competency areas.Results: A pool of more than 200 MCQs was compiled by the students for pilot use, of which 118 student-generated MCQs were used in the progress test. University instructors supplemented this pool with 26 MCQs, which primarily addressed the area of scientific skills. The post-review showed that student-generated MCQs were of high quality with regard to test statistic criteria and content. Overall, the progress test displayed a very high reliability. When the

SPIRIT: A seamless phase I/II randomized design for immunotherapy trials.

Science.gov (United States)

Guo, Beibei; Li, Daniel; Yuan, Ying

2018-06-07

Immunotherapy-treatments that enlist the immune system to battle tumors-has received widespread attention in cancer research. Due to its unique features and mechanisms for treating cancer, immunotherapy requires novel clinical trial designs. We propose a Bayesian seamless phase I/II randomized design for immunotherapy trials (SPIRIT) to find the optimal biological dose (OBD) defined in terms of the restricted mean survival time. We jointly model progression-free survival and the immune response. Progression-free survival is used as the primary endpoint to determine the OBD, and the immune response is used as an ancillary endpoint to quickly screen out futile doses. Toxicity is monitored throughout the trial. The design consists of two seamlessly connected stages. The first stage identifies a set of safe doses. The second stage adaptively randomizes patients to the safe doses identified and uses their progression-free survival and immune response to find the OBD. The simulation study shows that the SPIRIT has desirable operating characteristics and outperforms the conventional design. Copyright © 2018 John Wiley & Sons, Ltd.

How system designers think: a study of design thinking in human factors engineering.

Science.gov (United States)

Papantonopoulos, Sotiris

2004-11-01

The paper presents a descriptive study of design thinking in human factors engineering. The objective of the study is to analyse the role of interpretation in design thinking and the role of design practice in guiding interpretation. The study involved 10 system designers undertaking the allocation of cognitive functions in three production planning and control task scenarios. Allocation decisions were recorded and verbal protocols of the design process were collected to elicit the subjects' thought processes. Verbal protocol analysis showed that subjects carried out the design of cognitive task allocation as a problem of applying a selected automation technology from their initial design deliberations. This design strategy stands in contrast to the predominant view of system design that stipulates that user requirements should be thoroughly analysed prior to making any decisions about technology. Theoretical frameworks from design research and ontological design showed that the system design process may be better understood by recognizing the role of design hypotheses in system design, as well as the diverse interactions between interpretation and practice, means and ends, and design practice and the designer's pre-understanding which shape the design process. Ways to balance the bias exerted on the design process were discussed.

Repair of DNA treated with λ-irradiation and chemical carcinogens: Progress report, 1983-1987

International Nuclear Information System (INIS)

Goldthwait, D.A.

1987-08-01

Studies on the in vitro enzymatic mechanisms of DNA repair of chromatin structures are described. In addition new studies on signal transduction in cancer and in carcinogenesis are emphasized. We are using molecular biological approaches to three model systems, which we are developing. The first involves signal transduction controlling sis gene (platelet derived growth factor-β) mRNA levels in human glioblastoma cells. The second involves signal transduction in the activation of a long terminal repeat. The third involves an experiment designed to detect a tranposition event in a human cell. This progress report will summarize work on DNA repair of chromatin and then detail our progress in developing the three model systems. 59 refs., 14 figs., 7 tabs

Fear of progression in chronic diseases: psychometric properties of the Fear of Progression Questionnaire.

Science.gov (United States)

Herschbach, Peter; Berg, Petra; Dankert, Andrea; Duran, Gabriele; Engst-Hastreiter, Ursula; Waadt, Sabine; Keller, Monika; Ukat, Robert; Henrich, Gerhard

2005-06-01

The aim of this study was the development and psychometric testing of a new psychological questionnaire to measure the fear of progression (FoP) in chronically ill patients (cancer, diabetes mellitus and rheumatic diseases). The Fear of Progression Questionnaire (FoP-Q) was developed in four phases: (1) generation of items (65 interviews); (2) reduction of items--the initial version of the questionnaire (87 items) was presented to 411 patients, to construct subscales and test the reliability; (3) testing the convergent and discriminative validity of the reduced test version (43 items) within a new sample (n=439); (4) translation--German to English. The scale comprised five factors (Cronbach's alpha >.70): affective reactions (13 items), partnership/family (7), occupation (7), loss of autonomy (7) and coping with anxiety (9). The test-retest reliability coefficients varied between .77 and .94. There was only a medium relationship to traditional anxiety scales. This is an indication of the independence of the FoP. Significant relationships between the FoP-Q and the patient's illness behaviour indicate discriminative validity. The FoP-Q is a new and unique questionnaire developed for the chronically ill. A major problem and source of stress for this patient group has been measuring both specifically and economically the FoP of an illness. The FoP-Q was designed to resolve this problem, fulfill this need and reduce this stress.

Progress as Compositional Lock-Freedom

DEFF Research Database (Denmark)

Carbone, Marco; Dardha, Ornela; Montesi, Fabrizio

2014-01-01

A session-based process satisfies the progress property if its sessions never get stuck when it is executed in an adequate context. Previous work studied how to define progress by introducing the notion of catalysers, execution contexts generated from the type of a process. In this paper, we refine...... such definition to capture a more intuitive notion of context adequacy for checking progress. Interestingly, our new catalysers lead to a novel characterisation of progress in terms of the standard notion of lock-freedom. Guided by this discovery, we also develop a conservative extension of catalysers that does...

Progress report of preliminary studies of beryllium toxicity

Energy Technology Data Exchange (ETDEWEB)

Hodge, H.C.

1947-09-01

This document was prepared in connection with a symposium of beryllium poisoning held at the Saranac Laboratories and describes progress made and a research program aimed at characterizing the toxicity of beryllium. Seven individual papers in this document are separately indexed and cataloged for the database.

Progression of visual field in patients with primary open-angle glaucoma - ProgF study 1.

Science.gov (United States)

Aptel, Florent; Aryal-Charles, Nishal; Giraud, Jean-Marie; El Chehab, Hussam; Delbarre, Maxime; Chiquet, Christophe; Romanet, Jean-Paul; Renard, Jean-Paul

2015-12-01

To evaluate the visual field rate of progression of patients with treated ocular hypertension (OHT) and primary open-angle glaucoma (POAG) in clinical practice, using the mean deviation (MD) and the visual field index (VFI). Non-interventional cohort study. From a large multicentre database representative of the French population, 441 eyes of 228 patients with treated OHT or POAG followed up at least 6 years with Humphrey 24.2 Sita-Standard visual field examination at least twice a year were identified. From initial data, eyes were classified in five groups: 121 with OHT, 188 with early glaucoma (MD greater than -6 dB), 45 with moderate glaucoma (MD -6 to -12 dB), 41 with advanced glaucoma (MD -12 to -18 dB) and 46 with severe glaucoma (MD less than -18 dB). Rate of progression during the follow-up period was calculated using the trend analysis of the Guided Progression Analysis software. The mean duration of follow-up was 8.4 ± 2.7 years and the mean number of visual field, 18.4 ± 3.5. In eyes with OHT, rate of progression was -0.09 dB/year (-0.17%VFI/year). In eyes with POAG, rate of progression was -0.32 dB/year (-0.83%VFI/year) in eyes with early glaucoma, -0.52 dB/year (-1.81%VFI/year) in moderate glaucoma, -0.54 dB/year (-2.35%VFI/year) in advanced glaucoma and -0.45 dB/year (-1.97%VFI/year) in severe glaucoma. In eyes with POAG, a significant progression (p open-angle glaucoma is a progressive disease in the majority of patients despite cautioned treatment and follow-up. The rate of progression varies greatly among subjects. © 2015 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.

Chimeric immune receptors (CIRs) specific to JC virus for immunotherapy in progressive multifocal leukoencephalopathy (PML)

NARCIS (Netherlands)

W. Yang; E.L. Beaudoin; L. Lu; R.A. Du Pasquier (Renaud); M.J. Kuroda; R.A. Willemsen (Ralph); I.J. Koralnik; R.P. Junghans

2007-01-01

textabstractProgressive multifocal leukoencephalopathy (PML) is a deadly brain disease caused by the polyomavirus JC (JCV). The aim of this study is to develop 'designer T cells' armed with anti-JCV TCR-based chimeric immune receptors (CIRs) by gene modification for PML immunotherapy. Two T cell

Pregnancy-induced progression of keratoconus.

Science.gov (United States)

Bilgihan, Kamil; Hondur, Ahmet; Sul, Sabahattin; Ozturk, Sertac

2011-09-01

To report eyes with keratoconus that progressed during pregnancy. Seven eyes of 4 patients with progression of keratoconus during pregnancy were included in this study. The mean age of patients and the mean follow-up duration were 29.3 years and 39 months, respectively. Progressive keratoconus was documented with changes in refraction, corneal topography, and rigid gas-permeable lens fitting pattern. Patients with accompanying systemic and ocular diseases associated with keratoconus, uncontrolled atopic disease, and eye rubbing were excluded. Mean increase in spherical equivalent refraction and simulated keratometry values were 1.4 ± 1.1 and 1.1 ± 0.8 diopters, respectively. In eyes wearing rigid gas-permeable lenses, increase in corneal apical touch and decrease in the base curve radius of the best-fitting contact lens were observed. Hormonal changes during pregnancy may affect corneal biomechanics negatively, and pregnancy may be a previously unrecognized risk factor for progression of keratoconus. To our knowledge, this is the first study showing pregnancy-induced keratoconus progression in patients with no accompanying disease.

CML/CD36 accelerates atherosclerotic progression via inhibiting foam cell migration.

Science.gov (United States)

Xu, Suining; Li, Lihua; Yan, Jinchuan; Ye, Fei; Shao, Chen; Sun, Zhen; Bao, Zhengyang; Dai, Zhiyin; Zhu, Jie; Jing, Lele; Wang, Zhongqun

2018-01-01

Among the various complications of type 2 diabetes mellitus, atherosclerosis causes the highest disability and morbidity. A multitude of macrophage-derived foam cells are retained in atherosclerotic plaques resulting not only from recruitment of monocytes into lesions but also from a reduced rate of macrophage migration from lesions. Nε-carboxymethyl-Lysine (CML), an advanced glycation end product, is responsible for most complications of diabetes. This study was designed to investigate the mechanism of CML/CD36 accelerating atherosclerotic progression via inhibiting foam cell migration. In vivo study and in vitro study were performed. For the in vivo investigation, CML/CD36 accelerated atherosclerotic progression via promoting the accumulation of macrophage-derived foam cells in aorta and inhibited macrophage-derived foam cells in aorta migrating to the para-aorta lymph node of diabetic apoE -/- mice. For the in vitro investigation, CML/CD36 inhibited RAW264.7-derived foam cell migration through NOX-derived ROS, FAK phosphorylation, Arp2/3 complex activation and F-actin polymerization. Thus, we concluded that CML/CD36 inhibited foam cells of plaque migrating to para-aorta lymph nodes, accelerating atherosclerotic progression. The corresponding mechanism may be via free cholesterol, ROS generation, p-FAK, Arp2/3, F-actin polymerization. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

Tracking rehabilitative progress with Fitts and starts

DEFF Research Database (Denmark)

Knoche, Hendrik; Hald, Kasper; Tamsen, Danny

2015-01-01

We designed a tablet game to diagnose, train, and assess the rehabilitative progress of hemi-spatial neglect patients. We found that a set of parameters from fitting Fitts’ law to hit delays in a whack-a-mole game can be used to identify neglect patients due to the asymmetry between performance...

The Role of Time Perspective, Motivation, Attitude, and Preparation in Educational Choice and Study Progress

NARCIS (Netherlands)

Slijper, Jeany; Kunnen, Elske; Onstenk, Jeroen; van Geert, Paul

2016-01-01

The present study examined the relation between study progress in the first year of education and different aspects of the process of study choice of 89 students of higher professional education. This study consists of three parts. Firstly, we explored which concepts are important in open interviews

The art of progressive censoring applications to reliability and quality

CERN Document Server

Balakrishnan, N

2014-01-01

This monograph offers a thorough and updated guide to the theory and methods of progressive censoring, an area that has experienced tremendous growth in recent years. Progressive censoring, originally proposed in the 1950s, is an efficient method of handling samples from industrial experiments involving lifetimes of units that have either failed or censored in a progressive fashion during the life test, with many practical applications to reliability and quality. Key topics and features: Data sets from the literature as well as newly simulated data sets are used to illustrate concepts throughout the text Emphasis on real-life applications to life testing, reliability, and quality control Discussion of parametric and nonparametric inference Coverage of experimental design with optimal progressive censoring The Art of Progressive Censoring is a valuable reference for graduate students, researchers, and practitioners in applied statistics, quality control, life testing, and reliability. With its accessible style...

International linear collider. A technical progress report

Energy Technology Data Exchange (ETDEWEB)

Arnold, Ned [Argonne National Laboratory, IL (United States); Aderhold, Sebastian [DESY, Hamburg (Germany); Adolphsen, Chris [Stanford Linear Accelerator Center, Menlo Park, CA (United States); and others

2012-07-01

The International Linear Collider: A Technical Progress Report marks the halfway point towards the Global Design Effort fulfilling its mandate to follow up the ILC Reference Design Report with a more optimised Technical Design Report (TDR) by the end of 2012. The TDR will be based on much of the work reported here and will contain all the elements needed to propose the ILC to collaborating governments, including a technical design and implementation plan that are realistic and have been better optimised for performance, cost and risk. We are on track to develop detailed plans for the ILC, such that once results from the Large Hadron Collider (LHC) at CERN establish the main science goals and parameters of the next machine, we will be in good position to make a strong proposal for this new major global project in particle physics. The two overriding issues for the ILC R and D programme are to demonstrate that the technical requirements for the accelerator are achievable with practical technologies, and that the ambitious physics goals can be addressed by realistic ILC detectors. This GDE interim report documents the impressive progress on the accelerator technologies that can make the ILC a reality. It highlights results of the technological demonstrations that are giving the community increased confidence that we will be ready to proceed with an ILC project following the TDR. The companion detector and physics report document likewise demonstrates how detector designs can meet the ambitious and detailed physics goals set out by the ILC Steering Committee. LHC results will likely affect the requirements for the machine design and the detectors, and we are monitoring that very closely, intending to adapt our design as those results become available.

International Linear Collider-A Technical Progress Report

Energy Technology Data Exchange (ETDEWEB)

Elsen, Eckhard; /DESY; Harrison, Mike; /Brookhaven; Hesla, Leah; /Fermilab; Ross, Marc; /Fermilab; Royole-Degieux, Perrine; /Paris, IN2P3; Takahashi, Rika; /KEK, Tsukuba; Walker, Nicholas; /DESY; Warmbein, Barbara; /DESY; Yamamoto, Akira; /KEK, Tsukuba; Yokoya, Kaoru; /KEK, Tsukuba; Zhang, Min; /Beijing, Inst. High Energy Phys.

2011-11-04

The International Linear Collider: A Technical Progress Report marks the halfway point towards the Global Design Effort fulfilling its mandate to follow up the ILC Reference Design Report with a more optimised Technical Design Report (TDR) by the end of 2012. The TDR will be based on much of the work reported here and will contain all the elements needed to propose the ILC to collaborating governments, including a technical design and implementation plan that are realistic and have been better optimised for performance, cost and risk. We are on track to develop detailed plans for the ILC, such that once results from the Large Hadron Collider (LHC) at CERN establish the main science goals and parameters of the next machine, we will be in good position to make a strong proposal for this new major global project in particle physics. The two overriding issues for the ILC R&D programme are to demonstrate that the technical requirements for the accelerator are achievable with practical technologies, and that the ambitious physics goals can be addressed by realistic ILC detectors. This GDE interim report documents the impressive progress on the accelerator technologies that can make the ILC a reality. It highlights results of the technological demonstrations that are giving the community increased confidence that we will be ready to proceed with an ILC project following the TDR. The companion detector and physics report document likewise demonstrates how detector designs can meet the ambitious and detailed physics goals set out by the ILC Steering Committee. LHC results will likely affect the requirements for the machine design and the detectors, and we are monitoring that very closely, intending to adapt our design as those results become available.

Coordination: southeast continental shelf studies. Progress report

Energy Technology Data Exchange (ETDEWEB)

Menzel, D.W.

1981-02-01

The objectives are to identify important physical, chemical and biological processes which affect the transfer of materials on the southeast continental shelf, determine important parameters which govern observed temporal and spatial varibility on the continental shelf, determine the extent and modes of coupling between events at the shelf break and nearshore, and determine physical, chemical and biological exchange rates on the inner shelf. Progress in meeting these research objectives is presented. (ACR)

Progress Report 1994

International Nuclear Information System (INIS)

1995-01-01

This document is the 1994 annual progress report of the CEA-Direction of Waste Management (DGD). It comprises four chapters. The first chapter is a general presentation of radioactive wastes, of the management of liquid effluents, solid wastes, sealed sources, of the relations with the ANDRA (The French Agency for the Management of Radioactive Wastes), and of the research and development studies in progress for the improvement of waste management. The second chapter concerns the spent fuels and their reprocessing, in particular AGR and PWR type reactor fuels, the ''Caramel'' fuel from Osiris reactor and the cover elements from the Rapsodie reactor core. The long time storage of ancient fuels is also discussed. The third chapter concerns the dismantling of decommissioned installations, the actions in progress and the planning of dismantling actions up to the year 2000. Chapter four is devoted to the management of wastes from the Direction of Military Applications (DAM), the actions in progress in the different DAM centers and the cleansing projects at Marcoule plant. (J.S.). 5 figs., 28 tabs., 21 photos., 3 appendix

Low cost solar array project. Quarterly progress report, January-March, 1981

Energy Technology Data Exchange (ETDEWEB)

1981-01-01

The engineering design, fabrication, assembly, operation, economic analysis, and process support R and D for an Experimental Process System Development Unit (EPSDU) are presented. The civil construction work was completed and the mechanical bid package is in preparation. The electrical design effort is in progress. Parallel efforts which complement the mechanical design are the process flow diagrams and control instrumentation logic for startup operation and shutdown. These are in progress and will identify all process and utility streams, control systems, and flow logic. The data collection system takes the signals from the instrumentation, translates them into engineering units and finally develops a data report which summarizes all key performance parameters. Cleaning procedures have been established to assure a contamination-free product and inspection visits have been made to the fabricators of specialty equipment.

CERN: LHC progress

International Nuclear Information System (INIS)

Anon.

1993-01-01

The push for CERN's next major project, the LHC proton collider to be built in the 27-kilometre LEP tunnel, is advancing on a wide front. For the machine itself, there has been considerable progress in the detailed design. While the main thrust is for proton-proton collisions, heavy ions are also on the LHC collision menu. On the experimental side, proposals are coming into sharper focus. For the machine, the main aim is for the highest possible proton collision energies and collision rates in the confines of the existing LEP tunnel, and the original base design looked to achieve these goals in three collision regions. Early discussions on the experimental programme quickly established that the most probable configuration would have two collision regions rather than three. This, combined with hints that the electronics of several detectors would have to handle several bunch crossings at a time, raised the question whether the originally specified bunch spacing of 15 ns was still optimal

FFAG Designs for the International Design Study for the Neutrino Factory

Energy Technology Data Exchange (ETDEWEB)

Berg, J.S.; Machida, S.

2009-05-04

The International Design Study for the Neutrino Factory (IDS-NF) aims to produce a design report for a neutrino factory. One component of that design is a linear nonscaling fixed-field alternating gradient accelerator (FFAG) that will accelerate to the final energy of 25 GeV. An FFAG is used to reduce the machine cost by maximizing the number of passes made through the RF cavities. We present some design options for this FFAG, individually optimized for cost. We study the addition of nonlinear magnets to the lattice to improve the performance of the lattice and consider the negative effects of doing so.

A Method to Reveal Fine-Grained and Diverse Conceptual Progressions during Learning

Science.gov (United States)

Lombard, François; Merminod, Marie; Widmer, Vincent; Schneider, Daniel K.

2018-01-01

Empirical data on learners' conceptual progression is required to design curricula and guide students. In this paper, we present the Reference Map Change Coding (RMCC) method for revealing students' progression at a fine-grained level. The method has been developed and tested through the analysis of successive versions of the productions of eight…

FED/INTOR reactor design studies

International Nuclear Information System (INIS)

Brown, T.G.; Cramer, B.A.; Davisson, J.P.; Kunselman, M.H.; Reiersen, W.T.; Sager, P.H.; Strickler, D.J.

1982-03-01

Upon completing the design studies identified in this report, an overall assessment of the design options is made that will form the bases to define the configuration of the next major Tokamak device. The TF coil size will be defined, along with the vacuum boundary, the PF coil arrangement, and the torus configuration. After the configuration is established, an overall performance and cost re-assessment should be made to finally trade off device performance with machine capital and operating costs to establish a reactor design point for a given set of design requirements

Progress report 1981

International Nuclear Information System (INIS)

Chalupka, A.; Dirninger, G.

1982-01-01

The progress report describes the scientific work and research results of the institute for radium research and nuclear physics of the Austrian Academy of Sciences for the period of 1981. The progress report covers the subject areas of nuclear theory, nuclear model calculations, experimental nuclear physics and neutron involved reactions, medium energy physics, instrumentation and detectors, evaluation of nuclear data and numerical data processing, dating, applications in medicine, dosimetry and environmental studies. A list of publications of this institute is given. (A.N.)

Progress report 1982

International Nuclear Information System (INIS)

Chalupka, A.; Wild, E.; Dirninger, G.

1983-01-01

The progress report describes the scientific work and research results of the institute for radium research and nuclear physics of the Austrian Academy of Sciences for the period of 1982. The progress report covers the subject areas of nuclear theory, nuclear model calculations, experimental nuclear physics and neutron involved reactions, medium energy physics, instrumentation and detectors, evaluation of nuclear data and numerical data processing, dating, applications in medicine, dosimetry and environmental studies. A list of publications of this institute is given. (A.N.)

Harvard--MIT research program in short-lived radiopharmaceuticals. Progress report, September 1, 1977--April 30, 1978

International Nuclear Information System (INIS)

Adelstein, S.J.; Brownell, G.L.

1978-05-01

Progress is reported on the following studies: chemistry studies designed to achieve a more complete understanding of the fundamental chemistry of technetium in order to facilitate the design of future radiopharmaceuticals incorporating the radionuclide /sup 99m/Tc; the development of new radiopharmaceuticals intended to improve image quality and lower radiation doses by the use of short-lived radionuclides and disease-specific agents; the development of short-lived positron-emitting radionuclides which offer advantages in transverse section imaging of regional physiological processes; and studies of the toxic effects of particulate radiation

Progress of Design Improvements for APR1400 Computerized Procedure System from HFE V and V results and Design Experience

International Nuclear Information System (INIS)

Lee, Sungjin; Seong, Nokyu

2015-01-01

This study shows major already improved design features from the above three processes and a design proposal for to-be-improving items. APR1400 CPS has been verified and validated by the HFE process, internal design review and site acceptance tests. APR1400 Computerized Procedure System (CPS) has been applied to Shin-Kori Nuclear Power Plant (SKN) 3 and 4 units, Shin-Hanul Nuclear Power Plant (SHN) 1 and 2 units and Baraka Nuclear Power Plant (BNPP) 1, 2, 3 and 4 units. Since APR1400 CPS is a first-of-a-kind (FOAK) human machine interface (HMI) for executing a computerized procedure in the nuclear power plant's main control room in South Korea, it has been continuously improved through a) the human factor engineering (HFE) verification and validation (V and V), b) the internal design review and c) prototype tests. Human engineering discrepancies (HEDs) can be identified by the HFE V and V activity. Some HEDs of APR1400 CPS for SKN 3 and 4 and SHN 1 and 2 have been adopted as a role of design improvement in the CPS system while others were regarded as an operator training requirement or part of task contents. Various requests for improving the CPS have been collected from those results. A HMI system should be improved continuously for removing potential defects. Some of introduced design features in this paper has been adopted for APR1400 nuclear power plants. Some of them are under the review in the CPS design team of KHNP

Prevalence and progression of combined pulmonary fibrosis and emphysema in asymptomatic smokers: A case-control study

Energy Technology Data Exchange (ETDEWEB)

Chae, Kum Ju; Jin, Gong Yong; Han, Young Min; Kim, Yong Seek; Chon, Su Bin; Lee, Young Sun [Chonbuk National University Medical School and Hospital, Department of Radiology, Institute of Medical Science, Research Institute of Clinical Medicine, Jeonju, Jeonbuk (Korea, Republic of); Kwon, Keun Sang [Chonbuk National University Medical School, Department of Preventive Medicine, Research Institute of Clinical Medicine, Jeonju, Jeonbuk (Korea, Republic of); Choi, Hye Mi [Chonbuk National University, Department of Statistics and Institute of Applied Statistics, Jeonju, Jeonbuk (Korea, Republic of); Lynch, David [National Jewish Health, Department of Radiology, Denver, CO (United States)

2015-08-15

We aimed to estimate the prevalence of combined pulmonary fibrosis and emphysema (CPFE) and describe the follow-up CT results of CPFE in asymptomatic smokers. This study was retrospective, and approved by an institutional review board. CT images of 2,016 current or previous male smokers who underwent low-dose chest CT at our healthcare centre were reviewed. Quantitative CT analysis was used to assess the extent of emphysema, and two radiologists visually analyzed the extent of fibrosis. Changes in fibrosis (no change, improvement, or progression) were evaluated on follow-up CT imaging (n = 42). Kaplan-Meier survival analysis, multivariate logistic regression and its ROC curve were used for survival and progression analysis. The prevalence of CPFE among asymptomatic male smokers was 3.1 % (63/2,016). The median follow-up period was 50.4 months, and 72.7 % (16/22) of continued smoker had progressing fibrosis on follow-up CT. CPFE progressed more rapidly in continuous smokers than in former smokers (p = 0.002). The 3.5-year follow-up period after initial CPFE diagnosis maximized the sum of sensitivity and specificity of CPFE progression prediction in continuous smokers. The prevalence of CPFE turned out not to be inconsiderable in asymptomatic male smokers, but serial CT follow-up would be helpful in recognizing disease progression. (orig.)

Prevalence and progression of combined pulmonary fibrosis and emphysema in asymptomatic smokers: A case-control study

International Nuclear Information System (INIS)

Chae, Kum Ju; Jin, Gong Yong; Han, Young Min; Kim, Yong Seek; Chon, Su Bin; Lee, Young Sun; Kwon, Keun Sang; Choi, Hye Mi; Lynch, David

2015-01-01

We aimed to estimate the prevalence of combined pulmonary fibrosis and emphysema (CPFE) and describe the follow-up CT results of CPFE in asymptomatic smokers. This study was retrospective, and approved by an institutional review board. CT images of 2,016 current or previous male smokers who underwent low-dose chest CT at our healthcare centre were reviewed. Quantitative CT analysis was used to assess the extent of emphysema, and two radiologists visually analyzed the extent of fibrosis. Changes in fibrosis (no change, improvement, or progression) were evaluated on follow-up CT imaging (n = 42). Kaplan-Meier survival analysis, multivariate logistic regression and its ROC curve were used for survival and progression analysis. The prevalence of CPFE among asymptomatic male smokers was 3.1 % (63/2,016). The median follow-up period was 50.4 months, and 72.7 % (16/22) of continued smoker had progressing fibrosis on follow-up CT. CPFE progressed more rapidly in continuous smokers than in former smokers (p = 0.002). The 3.5-year follow-up period after initial CPFE diagnosis maximized the sum of sensitivity and specificity of CPFE progression prediction in continuous smokers. The prevalence of CPFE turned out not to be inconsiderable in asymptomatic male smokers, but serial CT follow-up would be helpful in recognizing disease progression. (orig.)

Factors Associated with Enhanced Gross Motor Progress in Children with Cerebral Palsy: A Register-Based Study.

Science.gov (United States)

Størvold, Gunfrid V; Jahnsen, Reidun B; Evensen, Kari Anne I; Romild, Ulla K; Bratberg, Grete H

2018-05-01

To examine associations between interventions and child characteristics; and enhanced gross motor progress in children with cerebral palsy (CP). Prospective cohort study based on 2048 assessments of 442 children (256 boys, 186 girls) aged 2-12 years registered in the Cerebral Palsy Follow-up Program and the Cerebral Palsy Register of Norway. Gross motor progress estimates were based on repeated measures of reference percentiles for the Gross Motor Function Measure (GMFM-66) in a linear mixed model. Mean follow-up time: 2.9 years. Intensive training was the only intervention factor associated with enhanced gross motor progress (mean 3.3 percentiles, 95% CI: 1.0, 5.5 per period of ≥3 sessions per week and/or participation in an intensive program). Gross motor function was on average 24.2 percentiles (95% CI: 15.2, 33.2) lower in children with intellectual disability compared with others. Except for eating problems (-10.5 percentiles 95% CI: -18.5, -2.4) and ankle contractures by age (-1.9 percentiles 95% CI: -3.6, -0.2) no other factors examined were associated with long-term gross motor progress. Intensive training was associated with enhanced gross motor progress over an average of 2.9 years in children with CP. Intellectual disability was a strong negative prognostic factor. Preventing ankle contractures appears important for gross motor progress.

Progress in Establishment of Fission Mo Production Technology in Korea

International Nuclear Information System (INIS)

Lee, Jun Sig

2013-01-01

Research activities have been made in both the development of the fission Mo production process and the designing of the production facility that will be established at Kijang, Korea including a new research reactor in 2017. Progress in the process development for target preparation, target dissolution, Mo extraction, and purification has been made. It is also a great concern to minimize the radioactive wastes or at least to generate the wastes in readily treatable forms in the project. After series of cold experiments, the target dissolution and solution formulation for a column operation are optimized. Progress in the design of the production facility has been made. Two trains of hot cells including the waste storages have been proposed for the alternative operation of the facility. A radioisotope production facility is designed to locate next to the fission Mo production building to provide a simpler and easier handling pathway of the products

The Potential Role of Cache Mechanism for Complicated Design Optimization

International Nuclear Information System (INIS)

Noriyasu, Hirokawa; Fujita, Kikuo

2002-01-01

This paper discusses the potential role of cache mechanism for complicated design optimization While design optimization is an application of mathematical programming techniques to engineering design problems over numerical computation, its progress has been coevolutionary. The trend in such progress indicates that more complicated applications become the next target of design optimization beyond growth of computational resources. As the progress in the past two decades had required response surface techniques, decomposition techniques, etc., any new framework must be introduced for the future of design optimization methods. This paper proposes a possibility of what we call cache mechanism for mediating the coming challenge and briefly demonstrates some promises in the idea of Voronoi diagram based cumulative approximation as an example of its implementation, development of strict robust design, extension of design optimization for product variety

The ALPHA project: A progress report

International Nuclear Information System (INIS)

Yadigaroglu, G.

1995-01-01

A review of the ALPHA project is presented, including a summary of progress and current status. The project comprises the experimental and analytical investigation of the long-term decay heat removal phenomena from the containment of the next generation of passive Advanced Light Water Reactors. In its present phase, the project is directed to the investigation of the Simplified Boiling Water Reactor (SBWR) Passive Containment Cooling system. The project includes separate-effects tests of containment phenomena (the LINX program). The effects of aerosols that may result from hypothetical severe accidents are also considered (the AIDA program). The construction and commissioning of the major ALPHA experimental facilities, PANDA, LINX-2 and AIDA is complete and the first series of tests are underway. Scaling studies have guided their design. Several small-scale experiments and studies have already produced valuable results

Vertebrate behavior and ecology. Progress report, July 1, 1976--June 30, 1977

Energy Technology Data Exchange (ETDEWEB)

Tester, J.R.; Siniff, D.B.

1977-07-01

Progress is summarized under six subprojects; engineering design and development; statistical procedures and quantitative methods for analysis of ecological and behavioral data; coexistence and population dynamics of selected vertebrates; application of radiotelemetry to selected problems in vertebrate censusing and population study; fish response to alterations in water quality resulting from power production; and seasonal migrations and habitat selection of the pronghorn antelope (Antilocapra americana).

Recent progress at NASA in LISA formulation and technology development

International Nuclear Information System (INIS)

Stebbins, R T

2008-01-01

Over the last year, the NASA half of the joint LISA project has focused its efforts on responding to a major review, and advancing the formulation and technology development of the mission. The NAS/NRC Beyond Einstein program assessment review will be described, including the outcome. The basis of the LISA science requirements has changed from detection determined by integrated signal-to-noise ratio to observation determined by uncertainty in the estimation of astrophysical source parameters. The NASA team has further defined the spacecraft bus design, participated in many design trade studies and advanced the requirements flow down and the associated current best estimates of performance. Recent progress in technology development is also summarized

Heat Exchanger/Humidifier Trade Study and Conceptual Design for the Constellation Space Suit Portable Life Support System Ventilation Subsystem

Science.gov (United States)

Paul, Heather L.; Sompayrac, Robert; Conger, Bruce; Chamberlain, Mateo

2009-01-01

As development of the Constellation Space Suit Element progresses, designing the most effective and efficient life support systems is critical. The baseline schematic analysis for the Portable Life Support System (PLSS) indicates that the ventilation loop will need some method of heat exchange and humidification prior to entering the helmet. A trade study was initiated to identify the challenges associated with conditioning the spacesuit breathing gas stream for temperature and water vapor control, to survey technological literature and resources on heat exchanger and humidifiers to provide solutions to the problems of conditioning the spacesuit breathing gas stream, and to propose potential candidate technologies to perform the heat exchanger and humidifier functions. This paper summarizes the results of this trade study and also describes the conceptual designs that NASA developed to address these issues.

Frank and Fearless: Supporting Academic Career Progression for Women in an Australian Program

Directory of Open Access Journals (Sweden)

Polly Parker

2018-02-01

Full Text Available The underrepresentation of women in senior positions continues to be a major challenge in higher education and most other industries. In Australia, the career trajectory for academic women stalls at a lower level than that of their male counterparts. Concern about this situation in one Australian university led to the design and delivery of a career progression program to support women’s advancement from senior lecturer to associate professor. This study details the main features of the program, designed to facilitate women’s transition from being leading academics to academic leaders through a focus on leadership and career progression. We report the participants’ perceptions of its value based on survey data. We conclude that leadership development is difficult work and requires a supportive environment where risk-taking is encouraged, where frank and fearless feedback is provided, and where the individual is required to examine assumptions and biases and to assume a leadership identity.

Design study and comparative evaluation of JSFR failed fuel detection system

Energy Technology Data Exchange (ETDEWEB)

Aizawa, K.; Chikazawa, Y.; Ishikawa, N. [Japan Atomic Energy Agency JAEA, 4002 Narita, Oarai, Higashi-ibaraki-gun, Ibaraki 311-1393 (Japan); Kubo, S. [Japan Atomic Power Company JAPC (Japan); Okazaki, H.; Mito, M. [Mitsubishi FBR Systems, Inc. MFBR (Japan); Tozawa, K. [Fuji Electric Co., Ltd. (Japan); Hayashi, M. [MitsubishiElectric Corporation (Japan)

2012-07-01

A conceptual design study of an advanced sodium-cooled fast reactor JSFR has progressed in the 'Fast Reactor Cycle Technology Development (FaCT) 'project in Japan. JSFR has two failed fuel detection systems in the core. One is a failed fuel detection (FFD) system which continuously monitors a fission product from failed fuel subassembly. The other is a failed fuel detection and location (FFDL) system which locates when it receives signals from FFD. The FFD system consists of a FFD-DN which detects delayed neutron (DN) in sodium and a FFD-CG which detects fission products in the cover gas of the reactor vessel. In this study, requirements to the FFD-DN and the FFD-DN design to meet the requirements were investigated for the commercial and demonstration JSFR. In the commercial JSFR, a sampling type FFD which collects sodium from the reactor vessel by sampling lines for DN detectors was adopted. The performances have been investigated and confirmed by a fluid analysis in the reactor upper plenum. In the demonstration JSFR, the performance of DN detectors installed on the primary cold-leg piping has been confirmed. For the FFDL systems, experiences in the previous fast reactors and the R and D of FFDL system for JSFR were investigated. This study focuses on the Selector-Valve and the Tagging-Gas FFDL systems. Operation experiences of the Selector-valve FFDL system were accumulated in PFR and Phenix. Tagging-gas system experiences were accumulated in EBR-II and FFTF. The feasibility of both FFDL systems for JSFR was evaluated. (authors)

Filtering data from the collaborative initial glaucoma treatment study for improved identification of glaucoma progression.

Science.gov (United States)

Schell, Greggory J; Lavieri, Mariel S; Stein, Joshua D; Musch, David C

2013-12-21

Open-angle glaucoma (OAG) is a prevalent, degenerate ocular disease which can lead to blindness without proper clinical management. The tests used to assess disease progression are susceptible to process and measurement noise. The aim of this study was to develop a methodology which accounts for the inherent noise in the data and improve significant disease progression identification. Longitudinal observations from the Collaborative Initial Glaucoma Treatment Study (CIGTS) were used to parameterize and validate a Kalman filter model and logistic regression function. The Kalman filter estimates the true value of biomarkers associated with OAG and forecasts future values of these variables. We develop two logistic regression models via generalized estimating equations (GEE) for calculating the probability of experiencing significant OAG progression: one model based on the raw measurements from CIGTS and another model based on the Kalman filter estimates of the CIGTS data. Receiver operating characteristic (ROC) curves and associated area under the ROC curve (AUC) estimates are calculated using cross-fold validation. The logistic regression model developed using Kalman filter estimates as data input achieves higher sensitivity and specificity than the model developed using raw measurements. The mean AUC for the Kalman filter-based model is 0.961 while the mean AUC for the raw measurements model is 0.889. Hence, using the probability function generated via Kalman filter estimates and GEE for logistic regression, we are able to more accurately classify patients and instances as experiencing significant OAG progression. A Kalman filter approach for estimating the true value of OAG biomarkers resulted in data input which improved the accuracy of a logistic regression classification model compared to a model using raw measurements as input. This methodology accounts for process and measurement noise to enable improved discrimination between progression and nonprogression

Interactive reliability analysis project. FY 80 progress report

International Nuclear Information System (INIS)

Rasmuson, D.M.; Shepherd, J.C.

1981-03-01

This report summarizes the progress to date in the interactive reliability analysis project. Purpose is to develop and demonstrate a reliability and safety technique that can be incorporated early in the design process. Details are illustrated in a simple example of a reactor safety system

Office of Waste Isolation. Progress report, November 1977. [National waste terminal storage

Energy Technology Data Exchange (ETDEWEB)

Rhines, R.C.; Asher, J.M. (eds.)

1977-12-28

This program is part of the National Waste Terminal Storage program. The Geologic Review Group meeting was held in New Orleans, November 16-17. Start-up of the near-surface heater experiment in the Conasauga Shale formation is under way at Oak Ridge. The first shipment of experimental equipment from Oak Ridge to Avery Island, Louisiana, for the dome salt in-situ test was successfully completed. On November 9-10, a design status review on the spent fuel repository conceptual design was held with Kaiser Engineers, Inc. On November 2, OWI personnel reviewed the progress on the Economic Studies with TRW representatives.

Progress in Studies of Electron-Cloud-Induced Optics Distortions at CesrTA

International Nuclear Information System (INIS)

Crittenden, James; Penn, Gregory; Venturini, Marco; Harkay, Katherine; Holtzapple, Robert; Pivi, Mauro; Wang, Lanfa

2012-01-01

The Cornell Electron Storage Ring Test Accelerator (CesrTA) program has included extensive measurements of coherent betatron tune shifts for a variety of electron and positron beam energies, bunch population levels, and bunch train configurations. The tune shifts have been shown to result primarily from the interaction of the beam with the space-charge field of the beam-induced low-energy electron cloud in the vacuum chamber. Comparison to several advanced electron cloud simulation codes has allowed determination of the sensitivity of these measurements to physical parameters characterizing the synchrotron radiation flux, the production of photo-electrons on the vacuum chamber wall, the beam emittance, lattice optics, and the secondary-electron yield model. We report on progress in understanding the cloud buildup and decay mechanisms in magnetic fields and in field-free regions, addressing quantitatively the precise determination of the physical parameters of the modeling. Validation of these models will serve as essential input in the design of damping rings for future high-energy linear colliders.

“Think of it as a Challenge”: Problematizing Pedagogical Strategies for Progression When Assessing Web-based University Courses

Directory of Open Access Journals (Sweden)

Anette Svensson

2015-09-01

Full Text Available The aim of this study is to analyse how a taxonomy-based course design can support students’ qualitative learning processes in online university courses. The paper presents a case study based on two online courses in comparative literature in Swedish and English. A document analysis has been applied to analyse the empirical material, which includes the syllabuses, study guides, and examination assignments connected to the courses. Socio-cultural aspects of learning processes, assessment and feedback, course design using a taxonomic structure (SOLO, and a progressive theory of literary studies (Langer’s theories of envisionment function as a framework. The results show that the examination assignments aim to further the students’ educational processes from stage 2 to stage 5 of the SOLO-taxonomy and, at the same time, through Langer’s four stances. While the course structure has a positive effect on the students’ general as well as literary progress, there are some pedagogical challenges with online teaching in literature that are discussed. In addition, the examination assignments could have been used as ways to strengthen the students’ socio-cultural learning. Furthermore, with little alterations, the examination assignments, which were all used as means of summative assessment, could also have been used formatively to assess the students’ progress.

Open Issues in Design Informatics

DEFF Research Database (Denmark)

McMahon, Chris

2017-01-01

Design informatics—the use of computers as a means of generating, communicating and sharing data, information and knowledge in design—has been a central theme in design research and practice for many years. This paper reviews the recent progress of research in design informatics, and makes...

Progress of thermal hydraulic evaluation methods and experimental studies on a sodium-cooled fast reactor and its safety in Japan

Energy Technology Data Exchange (ETDEWEB)

Kamide, Hideki, E-mail: kamide.hideki@jaea.go.jp; Ohshima, Hiroyuki, E-mail: ohshima.hiroyuki@jaea.go.jp; Sakai, Takaaki, E-mail: sakai.takaaki@jaea.go.jp; Tanaka, Masaaki, E-mail: tanaka.masaaki@jaea.go.jp

2017-02-15

Highlights: • Thermal hydraulic issues for safety design criteria of sodium cooled fast reactors. • Measurement of velocity data in a subchannel surrounded by wire wrapped fuel-pins. • Statistical evaluation of core hot spot temperature during natural circulation. • Simulation of dynamics of molten fuel pool in a core disruptive accident. • V&V procedure of a multi-dimensional thermal hydraulic code on thermal striping. - Abstract: In the framework of the Generation-IV International Forum, the safety design criteria (SDC) incorporating safety-related R&D results on innovative technologies and lessons learned from Fukushima Dai-ichi nuclear power plants accident has been established to provide the set of general criteria for the safety designs of structures, systems and components of Generation-IV Sodium-cooled Fast Reactors (Gen-IV SFRs). A number of thermal-hydraulic evaluations are necessary to meet the concept of the criteria in the design studies of Gen-IV SFRs. This paper focuses on four kinds of thermal-hydraulic issues associated with the SDC, i.e., fuel subassembly thermal-hydraulics, natural circulation decay heat removal, core disruptive accidents, and thermal striping. Progress of evaluation methods on these issues is shown with activities on verification and validation (V&V) and experimental studies towards commercialization of SFR in Japan. These evaluation methods are planned to be eventually integrated into a comprehensive numerical simulation system that can be applied to all possible phenomena in SFR systems and that can be expected to become an effective tool for the development of human resource and the handing our knowledge and technologies down.

Measuring and reporting on decommissioning progress

International Nuclear Information System (INIS)