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Sample records for design requirements target

  1. National Ignition Facility subsystem design requirements target positioning subsystem SSDR 1.8.2

    International Nuclear Information System (INIS)

    Pittenger, L.

    1996-01-01

    This Subsystem Design Requirement document is a development specification that establishes the performance, design, development and test requirements for the target positioner subsystem (WBS 1.8.2) of the NIF Target Experimental System (WBS 1.8)

  2. National Ignition Facility subsystem design requirements target diagnostics subsystem SSDR 1.8.3

    International Nuclear Information System (INIS)

    Lee, D.

    1996-01-01

    This SSDR establishes the performance, design, development and test requirements for the Target Experimental System's Diagnostic, WBS 1.8. 3. This includes the individual diagnostic components, the Target Diagnostic Data Acquisition System (Target DAS), the diagnostic vacuum system, the timing/fiducial system, and the EMI protection system

  3. National Ignition Facility subsystem design requirements target area auxiliary subsystem SSDR 1.8.6

    International Nuclear Information System (INIS)

    Reitz, T.

    1996-01-01

    This Subsystem Design Requirement (SSDR) establishes the performance, design, development, and test requirements for the Target Area Auxiliary Subsystems (WBS 1.8.6), which is part of the NIF Target Experimental System (WBS 1.8). This document responds directly to the requirements detailed in NIF Target Experimental System SDR 003 document. Key elements of the Target Area Auxiliary Subsystems include: WBS 1.8.6.1 Local Utility Services; WBS 1.8.6.2 Cable Trays; WBS 1.8.6.3 Personnel, Safety, and Occupational Access; WBS 1.8.6.4 Assembly, Installation, and Maintenance Equipment; WBS 1.8.6.4.1 Target Chamber Service System; WBS 1.8.6.4.2 Target Bay Service Systems

  4. Safety and environmental requirements and design targets for TIBER-II

    International Nuclear Information System (INIS)

    Piet, S.J.

    1987-09-01

    A consistent set of safety and environmental requirements and design targets was proposed and adopted for the TIBER-II (Tokamak Ignition/Burn Experimental Reactor) design effort. TIBER-II is the most recent US version of a fusion experimental test reactor (ETR). These safety and environmental design targets were one contribution of the Fusion Safety Program in the TIBER-II design effort. The other contribution, safety analyses, is documented in the TIBER-II design report. The TIBER-II approach, described here, concentrated on logical development of, first, a complete and consistent set of safety and environmental requirements that are likely appropriate for an ETR, and, second, an initial set of design targets to guide TIBER-II. Because of limited time in the TIBER-II design effort, the iterative process only included one iteration - one set of targets and one design. Future ETR design efforts should therefore build on these design targets and the associated safety analyses. 29 refs., 5 figs., 3 tabs

  5. European DEMO divertor target: Operational requirements and material-design interface

    Directory of Open Access Journals (Sweden)

    J.H. You

    2016-12-01

    Full Text Available Recently, an integrated program of conceptual design activities for the European DEMO reactor was launched in the framework of the EUROfusion Consortium, where reliable power handling capability was identified as one of the most critical scientific as well as technological challenges for a DEMO reactor. The divertor is the key in-vessel plasma-facing component being in charge of power exhaust and removal of impurity particles. The DEMO divertor target will have to withstand extreme thermal loads where the local peak heat flux is expected to reach up to 20 MW/m2 during slow transient events in DEMO. To assure sufficient heat removal capability of the divertor target against normal and transient operational scenarios under expected cumulative neutron dose of up to 13 dpa is one of the fundamental engineering challenges imposed on target design. To develop the design of the DEMO divertor and related technologies, an R&D work package ‘Divertor’ has been set up in this consortium. The subproject ‘Target Development’ is devoted to the development of the conceptual design and the core technologies of the plasma-facing target. Devising and implementing novel structural heat sink materials (e.g. W/Cu composites to advanced target design concepts is one of the major objectives of this subproject. In this paper, the underlying design requirements imposed by the envisaged power exhaust goal and the prominent material-design interface issues are discussed. In addition, the candidate design concepts being currently considered are presented together with the related material issues. Finally, the first results achieved so far are presented.

  6. Fusion target design

    International Nuclear Information System (INIS)

    Bangerter, R.O.

    1978-01-01

    Most detailed fusion target design is done by numerical simulation using large computers. Although numerical simulation is briefly discussed, this lecture deals primarily with the way in which basic physical arguments, driver technology considerations and economical power production requirements are used to guide and augment the simulations. Physics topics discussed include target energetics, preheat, stability and symmetry. A specific design example is discussed

  7. Requirements for design of accelerator, beam transport, and target in a study of thermonuclear reaction cross section

    Energy Technology Data Exchange (ETDEWEB)

    Itahashi, T; Takahisa, K; Fujiwara, M; Toki, H; Ejiri, H [Osaka Univ., Ibaraki (Japan). Research Center for Nuclear Physics; Ohsumi, H; Komori, M

    1997-03-01

    A compact accelerator with high current ion source, low energy beam transport elements and windowless gas target was designed to investigate the thermonuclear reaction cross section. The idea of this project focused on the cross section measurement of the fusion reaction data {sup 3}He+{sup 3}He-{sup 4}He+p+p at 25keV. The system will be installed in Otoh Cosmo Observatory (1270m.w.e.) to get rid of the huge cosmic and environmental background. It consists of NANOGUN ECR ion source, focusing elements made of permanent magnets window less {sup 3}He gas target and/or He{sup 3} plasma target and detector telescopes with low noise and low background. Requirements for these were discussed technically and various ideas were proposed. (author)

  8. National Ignition Facility subsystem design requirements laser and target area building (LTAB) SSDR 1.2.2.1

    International Nuclear Information System (INIS)

    Kempel, P.; Hands, J.

    1996-01-01

    This Subsystem Design Requirements (SSDR) document establishes the performance, design, and verification requirements for the conventional building systems and subsystems of the Laser and Target Area Building (LTAB), including those that house and support the operation of high-energy laser equipment and the operational flow of personnel and materials throughout the facility. This SSDR addresses the following subsystems associated with the LTAB: Building structural systems for the Target Bay, Switchyards, Diagnostic Building, Decontamination Area, Laser Bays, Capacitor Bays and Operations Support Area, and the necessary space associated with building-support equipment; Architectural building features associated with housing the space and with the operational cleanliness of the functional operation of the facilities; Heating, Ventilating, and Air Conditioning (HVAC) systems for maintaining a clean and thermally stable ambient environment within the facilities; Plumbing systems that provide potable water and sanitary facilities for the occupants, plus stormwater drainage for transporting rainwater; Fire Protection systems that guard against fire damage to the facilities and their contents; Material handling systems for transporting personnel and heavy materials within the building areas; Mechanical process piping systems for liquids and gases that provide cooling and other service to experimental laser equipment and components; Electrical power and grounding systems that provide service and standby power to building and experimental equipment, including lighting distribution and communications systems for the facilities; Instrumentation and control systems that ensure the safe operation of conventional facilities systems, such as those listed above. Detailed requirements for building subsystems that are not addressed in this document (such as specific sizes, locations, or capacities) are included in detail-level NIP Project Interface Control Documents (ICDS)

  9. Design of the FMIT lithium target

    International Nuclear Information System (INIS)

    Hassberger, J.A.; Annese, C.E.; Greenwell, R.K.; Ingham, J.G.; Miles, R.R.; Miller, W.C.

    1981-01-01

    Development of the liquid lithium target for the Fusion Materials Irradiation Test (FMIT) Facility is described. The target concept, major design goals and design requirements are presented. Progress made in the research and development areas leading to detailed design of the target is discussed. This progress, including experimental and analytic results, demonstrates that the FMIT target design is capable of meeting its major design goals and requirements

  10. Implementing Target Value Design.

    Science.gov (United States)

    Alves, Thais da C L; Lichtig, Will; Rybkowski, Zofia K

    2017-04-01

    An alternative to the traditional way of designing projects is the process of target value design (TVD), which takes different departure points to start the design process. The TVD process starts with the client defining an allowable cost that needs to be met by the design and construction teams. An expected cost in the TVD process is defined through multiple interactions between multiple stakeholders who define wishes and others who define ways of achieving these wishes. Finally, a target cost is defined based on the expected profit the design and construction teams are expecting to make. TVD follows a series of continuous improvement efforts aimed at reaching the desired goals for the project and its associated target value cost. The process takes advantage of rapid cycles of suggestions, analyses, and implementation that starts with the definition of value for the client. In the traditional design process, the goal is to identify user preferences and find solutions that meet the needs of the client's expressed preferences. In the lean design process, the goal is to educate users about their values and advocate for a better facility over the long run; this way owners can help contractors and designers to identify better solutions. This article aims to inform the healthcare community about tools and techniques commonly used during the TVD process and how they can be used to educate and support project participants in developing better solutions to meet their needs now as well as in the future.

  11. Requirements for design of accelerator, beam transport, and target in a study of thermonuclear reaction cross section

    Energy Technology Data Exchange (ETDEWEB)

    Itahashi, T.; Takahisa, K.; Ohsumi, H.; Komori, M.; Fujiwara, M.; Toki, H. [Osaka Univ., Suita (Japan)

    1997-02-01

    The process of pp-de{sup +}{nu} is the basic fusion reaction for hydrogen burning in the sun and the prime reaction in chain producing photons and neutrinos. There are many works of the theoretical estimation of the reaction rate in the reaction chain in the sun. The precise measurement of the nutrinos from the sun is one of the most important current physics issues. The rate of the pp-de{sup +}{nu} is too small to be measured in laboratories. The construction of a compact ion accelerator facility with high current, low energy transport and plasma target is planned at the underground laboratory in Otoh Cosmo Observatory of Research Center for Nuclear Physics. The plasma target by using the EBIS type synthesized plasma was proposed as a bare {sup 3}He target. The production of helium ions of each charge state was tested by using the present NEOMAFIOS ECR ion source, and the obtained current is shown. For noncontaminated, high current beam transport, the strong focusing system was introduced. The design of windowless gas target, plasma target, the detection of the energetic reaction particles of protons, digital calorimeter, the couple of ECR ion source and plasma target, and the underground laboratory are reported. (K.I.)

  12. Super liquid density target designs

    International Nuclear Information System (INIS)

    Pan, Y.L.; Bailey, D.S.

    1976-01-01

    The success of laser fusion depends on obtaining near isentropic compression of fuel to very high densities and igniting this fuel. To date, the results of laser fusion experiments have been based mainly on the exploding pusher implosion of fusion capsules consisting of thin glass microballoons (wall thickness of less than 1 micron) filled with low density DT gas (initial density of a few mg/cc). Maximum DT densities of a few tenths of g/cc and temperatures of a few keV have been achieved in these experiments. We will discuss the results of LASNEX target design calculations for targets which: (a) can compress fuel to much higher densities using the capabilities of existing Nd-glass systems at LLL; (b) allow experimental measurement of the peak fuel density achieved

  13. Target design for shock ignition

    International Nuclear Information System (INIS)

    Schurtz, G; Ribeyre, X; Lafon, M

    2010-01-01

    The conventional approach of laser driven inertial fusion involves the implosion of cryogenic shells of deuterium-tritium ice. At sufficiently high implosion velocities, the fuel ignites by itself from a central hot spot. In order to reduce the risks of hydrodynamic instabilities inherent to large implosion velocities, it was proposed to compress the fuel at low velocity, and ignite the compressed fuel by means of a convergent shock wave driven by an intense spike at the end of the laser pulse. This scheme, known as shock ignition, reduces the risks of shell break-up during the acceleration phase, but it may be impeded by a low coupling efficiency of the laser pulse with plasma at high intensities. This work provides a relationship between the implosion velocity and the laser intensity required to ignite the target by a shock. The operating domain of shock ignition at different energies is described.

  14. OMEGA polar-drive target designs

    International Nuclear Information System (INIS)

    Radha, P. B.; Marozas, J. A.; Marshall, F. J.; Shvydky, A.; Collins, T. J. B.; Goncharov, V. N.; McKenty, P. W.; Sangster, T. C.; Skupsky, S.; McCrory, R. L.; Meyerhofer, D. D.

    2012-01-01

    Low-adiabat polar-drive (PD) [Skupsky et al., Phys. Plasmas 11, 2763 (2004)] implosion designs for the OMEGA [Boehly et al., Opt. Commun. 133, 495 (1997)] laser are described. These designs for cryogenic deuterium–tritium and warm plastic shells use a temporal laser pulse shape with three pickets followed by a main pulse [Goncharov et al., Phys. Rev. Lett. 104, 165001 (2010)]. The designs are at two different on-target laser intensities, with different in-flight aspect ratios (IFARs). These designs permit studies of implosion energetics and target performance closer to ignition-relevant intensities (∼7 × 10 14 W/cm 2 at the quarter-critical surface, where nonlocal heat conduction and laser–plasma interactions can play an important role) but at lower values of IFAR ∼ 22 or at lower intensity (∼3 × 10 14 W/cm 2 ) but at a higher IFAR (IFAR ∼ 32, where shell instability can play an important role). PD geometry requires repointing of laser beams to improve shell symmetry. The higher-intensity designs optimize target performance by repointing beams to a lesser extent, compensating for the reduced equatorial drive by increasing the energies of the repointed beams. They also use custom beam profiles that improve equatorial illumination at the expense of irradiation at higher latitudes. These latter designs will be studied when new phase plates for the OMEGA Laser System, corresponding to the custom beam profiles, are obtained.

  15. Model Penentuan Nilai Target Functional Requirement Berbasis Utilitas

    Directory of Open Access Journals (Sweden)

    Cucuk Nur Rosyidi

    2012-01-01

    Full Text Available In a product design and development process, a designer faces a problem to decide functional requirement (FR target values. That decision is made under a risk since it is conducted in the early design phase using incomplete information. Utility function can be used to reflect the decision maker attitude towards the risk in making such decision. In this research, we develop a utility-based model to determine FR target values using quadratic utility function and information from Quality Function Deployment (QFD. A pencil design is used as a numerical example using quadratic utility function for each FR. The model can be applied for balancing customer and designer interest in determining FR target values.

  16. Design of the target area for the National Ignition Facility

    International Nuclear Information System (INIS)

    Foley, R.J.; Karpenko, V.P.; Adams, C.H.

    1997-01-01

    The preliminary design of the target area for the National Ignition Facility has been completed. The target area is required to meet a challenging set of engineering system design requirements and user needs. The target area must provide the appropriate conditions before, during, and after each shot. The repeated introduction of large amounts of laser energy into the chamber and subsequent target emissions represent new design challenges for ICF facility design. Prior to each shot, the target area must provide the required target illumination, target chamber vacuum, diagnostics, and optically stable structures. During the shot, the impact of the target emissions on the target chamber, diagnostics, and optical elements is minimized and the workers and public are protected from excessive prompt radiation doses. After the shot, residual radioactivation is managed to allow the required accessibility. Diagnostic data is retrieved, operations and maintenance activities are conducted, and the facility is ready for the next shot. The target area subsystems include the target chamber, target positioner, structural systems, target diagnostics, environmental systems, and the final optics assembly. The engineering design of the major elements of the target area requires a unique combination of precision engineering, structural analysis, opto-mechanical design, random vibration suppression, thermal stability, materials engineering, robotics, and optical cleanliness. The facility has been designed to conduct both x- ray driven targets and to be converted at a later date for direct drive experiments. The NIF has been configured to provide a wide range of experimental environments for the anticipated user groups of the facility. The design status of the major elements of the target area is described

  17. Requirements for Space Settlement Design

    Science.gov (United States)

    Gale, Anita E.; Edwards, Richard P.

    2004-02-01

    When large space settlements are finally built, inevitably the customers who pay for them will start the process by specifying requirements with a Request for Proposal (RFP). Although we are decades away from seeing the first of these documents, some of their contents can be anticipated now, and provide insight into the variety of elements that must be researched and developed before space settlements can happen. Space Settlement Design Competitions for High School students present design challenges in the form of RFPs, which predict basic requirements for space settlement attributes in the future, including structural features, infrastructure, living conveniences, computers, business areas, and safety. These requirements are generically summarized, and unique requirements are noted for specific space settlement locations and applications.

  18. Multiple Target Laser Designator (MTLD)

    Science.gov (United States)

    2007-03-01

    Optimized Liquid Crystal Scanning Element Optimize the Nonimaging Predictive Algorithm for Target Ranging, Tracking, and Position Estimation...commercial potential. 3.0 PROGRESS THIS QUARTER 3.1 Optimization of Nonimaging Holographic Antenna for Target Tracking and Position Estimation (Task 6) In

  19. Targeting and design of chilled water network

    International Nuclear Information System (INIS)

    Foo, Dominic C.Y.; Ng, Denny K.S.; Leong, Malwynn K.Y.; Chew, Irene M.L.; Subramaniam, Mahendran; Aziz, Ramlan; Lee, Jui-Yuan

    2014-01-01

    Highlights: • Minimum flowrate targeting for chilled water network. • Mixed series/parallel configuration of chilled water-using units. • Integrated cooling and chilled water networks. - Abstract: Chilled water is a common cooling agent used in various industrial, commercial and institutional facilities. In conventional practice, chilled water is distributed via chilled water networks (CHWNs) in parallel configuration to provide required air conditioning and/or equipment cooling in the heating, ventilating and air conditioning (HVAC) system. In this paper, process integration approach based on pinch analysis technique is used to address energy efficiency issues in the CHWN system for grassroots design problem. Graphical and algebraic targeting techniques are developed to identify the minimum chilled water flowrate needed to remove a given amount of heat load from the CHWN. Doing this leads to higher chilled water return temperature and enhanced energy efficiency of the HVAC system. A recent proposed network design technique is extended to synthesize the CHWN in a mixed series/parallel configuration. A novel concept of integrated cooling and chilled water networks (IWN) is also proposed in this work, with its targeting and design techniques presented. Hypothetical examples and an industrial case study are solved to elucidate the proposed approaches

  20. National Ignition Facility system design requirements conventional facilities SDR001

    International Nuclear Information System (INIS)

    Hands, J.

    1996-01-01

    This System Design Requirements (SDR) document specifies the functions to be performed and the minimum design requirements for the National Ignition Facility (NIF) site infrastructure and conventional facilities. These consist of the physical site and buildings necessary to house the laser, target chamber, target preparation areas, optics support and ancillary functions

  1. Spallation neutron source target station design, development, and commissioning

    Energy Technology Data Exchange (ETDEWEB)

    Haines, J.R., E-mail: hainesjr@ornl.gov; McManamy, T.J.; Gabriel, T.A.; Battle, R.E.; Chipley, K.K.; Crabtree, J.A.; Jacobs, L.L.; Lousteau, D.C.; Rennich, M.J.; Riemer, B.W.

    2014-11-11

    The spallation neutron source target station is designed to safely, reliably, and efficiently convert a 1 GeV beam of protons to a high flux of about 1 meV neutrons that are available at 24 neutron scattering instrument beam lines. Research and development findings, design requirements, design description, initial checkout testing, and results from early operation with beam are discussed for each of the primary target subsystems, including the mercury target, neutron moderators and reflector, surrounding vessels and shielding, utilities, remote handling equipment, and instrumentation and controls. Future plans for the mercury target development program are also briefly discussed.

  2. Optical and mechanical design of beam-target coupling sensor

    International Nuclear Information System (INIS)

    Wang Liquan; Li Tian'en; Feng Bin; Xiang Yong; Li Keyu; Zhong Wei; Liu Guodong

    2012-01-01

    A sensor based on conjugate principle has been designed for matching the light beams and the target in inertial confinement fusion. It can avoid the direct illumination of the simulation collimating light on the target under test in targeting processes. This paper introduces the optical and mechanical design of the sensor, according to its design functions and working principle. The resolution of the optical images obtained in experiments reaches 6 μm and the beam-target matching accuracy is 8.8 μm. The sensor has been successfully applied to the Shenguang-Ⅲ facility. Statistical analyses of the four-hole CH target images derived with pinhole camera shows that the targeting accuracy of the facility is better than 25 μm, satisfying the design requirements. (authors)

  3. Technical Design Report, Second Target Station

    International Nuclear Information System (INIS)

    Galambos, John D.; Anderson, David E.; Bethea, Katie L.; Carden, W. F.; Chae, Steven M.; Bechtol, D.; Brown, N.; Clark, A.

    2015-01-01

    The Second Target Station (STS) is a proposed upgrade for SNS. It includes a doubling of the accelerator power and an additional instrument hall. The new instrument hall will receive a 467 kW 10 Hz beam. The parameters and preliminary design aspects of the STS are presented for the accelerator, target systems, instrument hall, instruments and civil construction aspects.

  4. Cold vacuum drying facility design requirements

    International Nuclear Information System (INIS)

    IRWIN, J.J.

    1999-01-01

    This document provides the detailed design requirements for the Spent Nuclear Fuel Project Cold Vacuum Drying Facility. Process, safety, and quality assurance requirements and interfaces are specified

  5. Cold vacuum drying facility design requirements

    Energy Technology Data Exchange (ETDEWEB)

    IRWIN, J.J.

    1999-07-01

    This document provides the detailed design requirements for the Spent Nuclear Fuel Project Cold Vacuum Drying Facility. Process, safety, and quality assurance requirements and interfaces are specified.

  6. Design of the LBNF Beamline Target Station

    Energy Technology Data Exchange (ETDEWEB)

    Tariq, S. [Fermilab; Ammigan, K. [Fermilab; Anderson, K.; ; Buccellato, S. A. [Fermilab; Crowley, C. F. [Fermilab; Hartsell, B. D. [Fermilab; Hurh, P. [Fermilab; Hylen, J. [Fermilab; Kasper, P. [Fermilab; Krafczyk, G. E. [Fermilab; Lee, A. [Fermilab; Lundberg, B. [Fermilab; Reitzner, S. D. [Fermilab; Sidorov, V. [Fermilab; Stefanik, A. M. [Fermilab; Tropin, I. S. [Fermilab; Vaziri, K. [Fermilab; Williams, K. [Fermilab; Zwaska, R. M. [Fermilab; Densham, C. [RAL, Didcot

    2016-10-01

    The Long Baseline Neutrino Facility (LBNF) project will build a beamline located at Fermilab to create and aim an intense neutrino beam of appropriate energy range toward the DUNE detectors at the SURF facility in Lead, South Dakota. Neutrino production starts in the Target Station, which consists of a solid target, magnetic focusing horns, and the associated sub-systems and shielding infrastructure. Protons hit the target producing mesons which are then focused by the horns into a helium-filled decay pipe where they decay into muons and neutrinos. The target and horns are encased in actively cooled steel and concrete shielding in a chamber called the target chase. The reference design chase is filled with air, but nitrogen and helium are being evaluated as alternatives. A replaceable beam window separates the decay pipe from the target chase. The facility is designed for initial operation at 1.2 MW, with the ability to upgrade to 2.4 MW, and is taking advantage of the experience gained by operating Fermilab’s NuMI facility. We discuss here the design status, associated challenges, and ongoing R&D and physics-driven component optimization of the Target Station.

  7. Tool-based requirement traceability between requirement and design artifacts

    CERN Document Server

    Turban, Bernhard

    2013-01-01

    Processes for developing safety-critical systems impose special demands on ensuring requirements traceability. Achieving valuable traceability information, however, is especially difficult concerning the transition from requirements to design. Bernhard Turban analyzes systems and software engineering theories cross-cutting the issue (embedded systems development, systems engineering, software engineering, requirements engineering and management, design theory and processes for safety-critical systems). As a solution, the author proposes a new tool approach to support designers in their thinkin

  8. Design of the MYRRHA Spallation Target Assembly

    International Nuclear Information System (INIS)

    Keijers, S.; Fernandez, R.; Stankovskiy, A.; Kennedy, G.; Van Tichelen, K.

    2015-01-01

    MYRRHA (Multi-purpose hybrid Research Reactor for High-tech Applications) is a multi-purpose research facility currently being developed at SCK.CEN. MYRRHA is based on the ADS (Accelerator Driven System) concept where a proton accelerator, a spallation target and a subcritical reactor are coupled. MYRRHA will demonstrate the ADS full concept by coupling these three components at a reasonable power level. As a flexible irradiation facility, the MYRRHA research reactor will be able to work in both critical and subcritical modes. In this way, MYRRHA will allow fuel developments for innovative reactor systems, material research for GEN IV and fusion reactors, and radioisotope production for medical and industrial applications. MYRRHA will be cooled by Lead Bismuth Eutectic (LBE) and will play an important role in the development of the Pb-alloys technology needed for the LFR (Lead Fast Reactor) GEN IV concept. This paper describes the evolution of the MYRRHA spallation target design. In the early phase of the MYRRHA project (XT-ADS), the target design was based on a dedicated spallation loop inside the primary reactor vessel. Within the core, the 3 central fuel assembly positions were occupied by the spallation target, which enabled a windowless design created by a free surface of LBE facing the proton beam. The windowless option was preferred because of high heat loads in combination with severe irradiation damage in the target region would result in unacceptably short lifetimes of a target window. The LBE in the loop served as spallation target and as target coolant, but was separated from the LBE cooling the reactor core. The loop was equipped with its own pump, heat exchanger and conditioning system. The change from cyclotron to linear accelerator allowed the increase in proton energy from 350 MeV to 600 MeV. This modification led to an important reduction of the specific heat load at the target level and an improvement of the neutronic performance. In addition to

  9. Design requirement on HYPER blanket fuel assembly

    International Nuclear Information System (INIS)

    Hwang, Woan; Lee, B. O.; Nam, C.; Ryu, W. S.; Lee, B. S.; Park, W. S.

    2000-07-01

    This document describes design requirements which are needed for designing the blanket assembly of the HYPER as design guidance. The blanket assembly of the HYPER consists of blanket fuel rods, mounting rail, spacer, upper nozzle with handling socket, bottom nozzle with mounting rail and skeleton structure. The blanket fuel rod consists of top end plug, bottom end plug with key way, blanket fuel slug, and cladding. In the assembly, the rods are in a triangular pitch array. This report contains functional requirements, performance and operational requirements, interfacing systems requirements, core restraint and interface requirements, design limits and strength requirements, system configuration and essential feature requirements, seismic requirements, structural requirements, environmental requirements, reliability and safety requirements, standard and codes, QA programs, and other requirements for the blanket fuel assembly of the HYPER

  10. Cold vacuum drying facility design requirements

    Energy Technology Data Exchange (ETDEWEB)

    Irwin, J.J.

    1997-09-24

    This release of the Design Requirements Document is a complete restructuring and rewrite to the document previously prepared and released for project W-441 to record the design basis for the design of the Cold Vacuum Drying Facility.

  11. Cold vacuum drying facility design requirements

    International Nuclear Information System (INIS)

    Irwin, J.J.

    1997-01-01

    This release of the Design Requirements Document is a complete restructuring and rewrite to the document previously prepared and released for project W-441 to record the design basis for the design of the Cold Vacuum Drying Facility

  12. Nonfunctional requirements in systems analysis and design

    CERN Document Server

    Adams, Kevin MacG

    2015-01-01

    This book will help readers gain a solid understanding of non-functional requirements inherent in systems design endeavors. It contains essential information for those who design, use, and maintain complex engineered systems, including experienced designers, teachers of design, system stakeholders, and practicing engineers. Coverage approaches non-functional requirements in a novel way by presenting a framework of four systems concerns into which the 27 major non-functional requirements fall: sustainment, design, adaptation, and viability. Within this model, the text proceeds to define each non-functional requirement, to specify how each is treated as an element of the system design process, and to develop an associated metric for their evaluation. Systems are designed to meet specific functional needs. Because non-functional requirements are not directly related to tasks that satisfy these proposed needs, designers and stakeholders often fail to recognize the importance of such attributes as availability, su...

  13. 49 CFR 229.206 - Design requirements.

    Science.gov (United States)

    2010-10-01

    ...-climber, emergency egress, emergency interior lighting, and interior configuration design requirements set... 49 Transportation 4 2010-10-01 2010-10-01 false Design requirements. 229.206 Section 229.206..., DEPARTMENT OF TRANSPORTATION RAILROAD LOCOMOTIVE SAFETY STANDARDS Locomotive Crashworthiness Design...

  14. CFD aspects of ADSS target design

    International Nuclear Information System (INIS)

    Shashi Kumar, G.N.; Mahendra, A.K.; Sanyal, A.; Gouthaman, G.

    2004-03-01

    The preliminary studies on CFD aspects of Accelerator Driven Sub-critical System (ADSS) target design has been presented in this report. The studies involve the thermal hydraulic analysis of the Liquid Metal Spallation Target (LMST) using Lead Bismuth Eutectic (LBE) as the target material. Apart from acting as Spallation medium LBE is used to remove the heat deposited by High Energy Proton Beam. Window of the target ( one side vacuum and other side LBE) has been reported in literature to be the most critical zone where high temperatures are reached. Numerical Simulations are carried out with Artificial Neural Network coupled Computational Fluid Dynamics (CFD) code, Various studies were carried out after the verification and validation of the initial results. Window being, the main parameter to be optimised, various designs of window were tried, along with change in the window material. The best possible combination has been proposed. The thermal hydraulic studies were carried out to arrive at the acceptable operating conditions for the target. (author)

  15. Test of a High Power Target Design

    CERN Multimedia

    2002-01-01

    %IS343 :\\\\ \\\\ A high power tantalum disc-foil target (RIST) has been developed for the proposed radioactive beam facility, SIRIUS, at the Rutherford Appleton Laboratory. The yield and release characteristics of the RIST target design have been measured at ISOLDE. The results indicate that the yields are at least as good as the best ISOLDE roll-foil targets and that the release curves are significantly faster in most cases. Both targets use 20 -25 $\\mu$m thick foils, but in a different internal geometry.\\\\ \\\\Investigations have continued at ISOLDE with targets having different foil thickness and internal geometries in an attempt to understand the release mechanisms and in particular to maximise the yield of short lived isotopes. A theoretical model has been developed which fits the release curves and gives physical values of the diffusion constants.\\\\ \\\\The latest target is constructed from 2 $\\mu$m thick tantalum foils (mass only 10 mg) and shows very short release times. The yield of $^{11}$Li (half-life of ...

  16. Safety design requirements for safety systems and components of JSFR

    International Nuclear Information System (INIS)

    Kubo, Shigenobu; Shimakawa, Yoshio; Yamano, Hidemasa; Kotake, Shoji

    2011-01-01

    Safety design requirements for JSFR were summarized taking the development targets of the FaCT project and design feature of JSFR into account. The related safety principle and requirements for Monju, CRBRP, PRISM, SPX, LWRs, IAEA standards, goals of GIF, basic principle of INPRO etc. were also taken into account so that the safety design requirements can be a next-generation global standard. The development targets for safety and reliability are set based on those of FaCT, namely, ensuring safety and reliability equal to future LWR and related fuel cycle facilities. In order to achieve these targets, the defence-in-depth concept is used as the basic safety design principle. General features of the safety design requirements are 1) Achievement of higher reliability, 2) Achievement of higher inspectability and maintainability, 3) Introduction of passive safety features, 4) Reduction of operator action needs, 5) Design consideration against Beyond Design Basis Events, 6) In-Vessel Retention of degraded core materials, 7) Prevention and mitigation against sodium chemical reactions, and 8) Design against external events. The current specific requirements for each system and component are summarized taking the basic design concept of JSFR into account, which is an advanced loop-type large-output power plant with a mixed-oxide-fuelled core. (author)

  17. Conceptual design study of IFMIF target system

    International Nuclear Information System (INIS)

    Kato, Y.; Nakamura, H.; Ida, M.; Maekawa, H.; Katsuta, H.; Hua, T.; Cevolani, S.

    1997-01-01

    IFMIF-CDA (International Fusion Materials Irradiation Facility - Conceptual Design Activity) had been carried out during 1995 and 1996, under the auspices of the IEA. The mission of this facility is to provide an accelerator based deuterium-lithium (D-Li) neutron source to test the candidate materials of radiation - resistant and low - activation materials up to about a full lifetime of anticipated use in fusion energy reactors. The neutrons of about 14 MeV are obtained by the stripping reaction of the deuteron of Max. 40 MeV with target lithium. Total deuteron beam current is about 250 mA and beam footprint is 20 cm x 5 cm on the free surface of lithium jet. In this report general characteristics of the target lithium system and the results of thermal and flow analysis for the target lithium jet are described. (author)

  18. LBNF 1.2 MW TARGET: CONCEPTUAL DESIGN & FABRICATION

    Energy Technology Data Exchange (ETDEWEB)

    Crowley, Cory F. [Fermilab; Ammigan, K. [Fermilab; Anderson, K. [Fermilab; Hartsell, B. [Fermilab; Hurh, P. [Fermilab; Hylen, J. [Fermilab; Zwaska, R. [Fermilab

    2015-06-29

    Fermilab’s Long-Baseline Neutrino Facility (LBNF) will utilize a modified design based on the NuMI low energy target that is reconfigured to accommodate beam operation at 1.2 MW. Achieving this power with a graphite target material and ancillary systems originally rated for 400 kW requires several design changes and R&D efforts related to material bonding and electrical isolation. Target cooling, structural design, and fabrication techniques must address higher stresses and heat loads that will be present during 1.2 MW operation, as the assembly will be subject to cyclic loads and thermal expansion. Mitigations must be balanced against compromises in neutrino yield. Beam monitoring and subsystem instrumentation will be updated and added to ensure confidence in target positioning and monitoring. Remote connection to the target hall support structure must provide for the eventual upgrade to a 2.4 MW target design, without producing excessive radioactive waste or unreasonable exposure to technicians during reconfiguration. Current designs and assembly layouts will be presented, in addition to current findings on processes and possibilities for prototype and final assembly fabrication.

  19. LBNF 1.2 MW Target: Conceptual Design & Fabrication

    Energy Technology Data Exchange (ETDEWEB)

    Crowley, C. [Fermilab; Ammigan, K. [Fermilab; Anderson, K. [Fermilab; Hartsell, B. [Fermilab; Hurh, P. [Fermilab; Hylen, J. [Fermilab; Zwaska, R. [Fermilab

    2015-06-01

    Fermilab’s Long-Baseline Neutrino Facility (LBNF) will utilize a modified design based on the NuMI low energy target that is reconfigured to accommodate beam operation at 1.2 MW. Achieving this power with a graphite target material and ancillary systems originally rated for 400 kW requires several design changes and R&D efforts related to material bonding and electrical isolation. Target cooling, structural design, and fabrication techniques must address higher stresses and heat loads that will be present during 1.2 MW operation, as the assembly will be subject to cyclic loads and thermal expansion. Mitigations must be balanced against compromises in neutrino yield. Beam monitoring and subsystem instrumentation will be updated and added to ensure confidence in target positioning and monitoring. Remote connection to the target hall support structure must provide for the eventual upgrade to a 2.4 MW target design, without producing excessive radioactive waste or unreasonable exposure to technicians during reconfiguration. Current designs and assembly layouts will be presented, in addition to current findings on processes and possibilities for prototype and final assembly fabrication.

  20. Test design requirements: Thermal conductivity probe testing

    International Nuclear Information System (INIS)

    Heath, R.E.

    1985-01-01

    This document establishes the test design requirements for development of a thermal conductivity probe test. The thermal conductivity probe determines in situ thermal conductivity using a line source transient heat conduction analysis. This document presents the rationale for thermal conductivity measurement using a thermal conductivity probe. A general test description is included. Support requirements along with design constraints are detailed to allow simple design of the thermal conductivity probe and test. The schedule and delivery requirements of the responsible test designer are also included. 7 refs., 1 fig

  1. Understand the Design Requirement in Companies

    DEFF Research Database (Denmark)

    Li, Xuemeng; Ahmed-Kristensen, Saeema

    2015-01-01

    requirements can lead to inappropriate products (Hall, et al., 2002). Understanding the nature of design requirements and the sources, from where they can or should be generated, is critical to before developing methods and processes to support this process. Requirement Engineering research, originated from...

  2. Design requirements for the new reactor

    International Nuclear Information System (INIS)

    Koski, S.

    2005-01-01

    This presentation deals with the safety related design requirements specified for the new nuclear power plant to be built in Finland (FINS). The legislation, codes and standards, on which the design requirements are based, can be arranged into a hierarchical pyramid as follows: The safety related design criteria are based on the three uppermost hierarchical levels: Finnish legislation (e.g. decisions of the State Council) Basic Regulations (75-INSAG-3, USNRC General Design Criteria) Process oriented nuclear documents (YVL- guides or corresponding US/German rules). The European Utility Requirements (EUR) document was used as the starting point for the writing of the design requirements document. The structure and headlines of EUR could be kept, but in many cases the contents had to be deleted and rewritten to correspond to the requirement level of the above codes and standards. This was the case, for example, with the requirements concerning safety classification or application of failure criteria. In the presentation, the most important safety related design criteria are reviewed, with an emphasis on those requirements which exceed the requirement level applied on the existing plant units. Some hints are also given on the main differences between Finnish and international safety requirements. (orig.)

  3. Present status of the conceptual design of IFMIF target facility

    International Nuclear Information System (INIS)

    Katsuta, H.; Kato, Y.; Konishi, S.; Miyauchi, Y.; Smith, D.; Hua, T.; Green, L.; Benamati, G.; Cevolani, S.; Roehrig, H.; Schutz, W.

    1998-01-01

    The conceptual design activity (CDA) for the international fusion materials irradiation facility (IFMIF) has been conducted. For the IFMIF target facility, the conceptual designs of the following two main components have been performed. The design concept of IFMIF utilizes a high energy deuteron beam of 30-40 MeV and total current of 250 mA, impinging on a flowing lithium jet to produce high energy neutrons for irradiation of candidate fusion materials. (1) The target assembly: The kinetic energy of the deuteron beam is deposited on a Li-jet target and neutrons are produced through the d-Li stripping reaction in this target. The assembly is designed to get a stable lithium jet and to prevent the onset of lithium boiling. For 40-MeV deuteron beam (total current of 250 mA) and a beam footprint of 5 x 20 cm 2 lithium jet dimensions are designed to be 2.5 cm thick and 26 cm wide. The lithium jet parameters are given. (2) Lithium loop: The loop circulates the lithium to and from the target assembly and removes the heat deposited by the deuteron beam containing systems for maintaining the-high purity of the lithium required for radiological safety and to minimize corrosion. The maximum lithium flow rate is 130 l/s and the total lithium inventory is about 21 m 3 . The IFMIF policy requires that the lithium loop system be designed to guarantee no combustion of lithium in the event of a lithium leak. This can be achieved by use of multiple confinement of the lithium carrying components. The radioactive waste generated by the target facilities is estimated. (orig.)

  4. Target design for heavy ion beam fusion

    International Nuclear Information System (INIS)

    Meyer-ter-Vehn, J.; Metzler, N.

    1981-07-01

    Target design for Heavy Ion Beam Fusion and related physics are discussed. First, a modified version of the Kidder-Bodner model for pellet gain is presented and is used to define the working point (Esub(beam) = 4.8 MJ, Gain 83) for a reactor size target. Secondly, stopping of heavy ions in hot dense plasma is investigated and numerical results for stopping powers and ranges of 10 GeV Bi-ions in Pb, Li, and PbLi-alloy are given. Finally, results of an explicit implosion calculation, using the 1-D code MINIHY, are discussed in detail. The hydrodynamic efficiency is found to be about 5%. Special attention is given to the shock sequence leading to the ignition configuration. Also the growth of Rayleigh-Taylor instability at the absorber-pusher interface is estimated. (orig.)

  5. Investigation of IFMIF target assembly structure design

    International Nuclear Information System (INIS)

    Ida, Mizuho; Nakamura, Hiroo; Sugimoto, Masayoshi; Yamamura, Toshio

    2006-10-01

    In the International Fusion Materials Irradiation Facility (IFMIF), the back-wall of target assembly is the part suffered the highest neutron-flux. The back-wall and the assembly are designed to have lips for cutting/welding at the back-wall replacement. To reduce thermal stress and deformation of the back-wall under neutron irradiation, contact pressure between the back-wall and the assembly is one of dominant factors. Therefore, an investigation was performed for feasible clamping pressure of a mechanical clamp set in limited space around the back-wall. It was clarified that the clamp can give a pressure difference up to 0.4 MPa between the contact pressure and atmosphere pressure in the test cell room. Also a research was performed for the dissimilar metal welding in the back-wall. Use of 309 steel was found adequate as the intermediate filler metal through the research of previous welding. Maintaining a temperature of the target assembly so as to avoid a freezing of liquid lithium is needed at the lithium charge into the loop before the beam injection. The assembly is covered with thermal insulation. Therefore, a research and an investigation were performed for compact and light thermal-insulation effective even under helium (i.e. high heat-conduction) condition of the test cell room. The result was as follows; in the case that a thermal conductivity 0.008 W/m·K of one of found insulation materials is available in the temperature range up to 300degC of the IFMIF target assembly, needed thickness and weight of the insulation were respectively only 8.2 mm and 32 kg. Also a research was performed for high-heat-density heaters to maintain temperature of the back-wall which can not be cover with insulation due to limited space. A heater made of silicon-nitride was found to be adequate. Total heat of 8.4 kW on the back-wall was found to be achievable through an investigations of heater arrange. Also an investigation was performed for remote-handling device to

  6. Systems engineering requirements impacting MHTGR circulator design

    International Nuclear Information System (INIS)

    Chi, H.W.; Baccaglini, G.M.; Potter, R.C.; Shenoy, A.S.

    1988-01-01

    At the initiation of the MHTGR program, an important task involved translating the plant users' requirements into design conditions. This was particularly true in the case of the heat transport and shutdown cooling systems since these embody many components. This paper addresses the two helium circulators in these systems. An integrated approach is being used in the development of design and design documentation for the MHTGR plant. It is an organized and systematic development of plant functions and requirements, determined by top-down design, performance, and cost trade-off studies and analyses, to define the overall plant systems, subsystems, components, and human actions. These studies, that led to the identification of the major design parameters for the two circulators, are discussed in this paper. This includes the performance information, steady state and transient data, and the various interface requirements. The design of the circulators used in the MHTGR is presented. (author). 1 ref., 17 figs

  7. Some Aspects on Filter Design for Target Tracking

    Directory of Open Access Journals (Sweden)

    Bertil Ekstrand

    2012-01-01

    Full Text Available Tracking filter design is discussed. It is argued that the basis of the present stochastic paradigm is questionable. White process noise is not adequate as a model for target manoeuvring, stochastic least-square optimality is not relevant or required in practice, the fact that requirements are necessary for design is ignored, and root mean square (RMS errors are insufficient as performance measure. It is argued that there is no process noise and that the covariance of the assumed process noise contains the design parameters. Focus is on the basic tracking filter, the Kalman filter, which is convenient for clarity and simplicity, but the arguments and conclusions are relevant in general. For design the possibility of an observer transfer function approach is pointed out. The issues can also be considered as a consequence of the fact that there is a difference between estimation and design. The - filter is used for illustration.

  8. Supplemental design requirements document, Project W026

    International Nuclear Information System (INIS)

    Weidert, J.R.

    1993-01-01

    This document supplements and extends the Functional Design Criteria, SP-W026-FDC-001, for the Waste Receiving and Processing Facility (WRAP), Module 1. It provides additional detailed requirements, summarizes key Westinghouse Hanford Company design guidance, and establishes baseline technical agreements to be used in definitive design of the WRAP-1 facility. Revision 3 of the Supplemental Design Requirements Document has been assigned an Impact Level of 3ESQ based on the content of the entire revision. The actual changes made from Revision 2 have an Impact Level of 3S and the basis for these changes was previously reviewed and approved per WHC correspondence No. 9355770

  9. Targeted proteins for diabetes drug design

    Science.gov (United States)

    Doan Trang Nguyen, Ngoc; Thi Le, Ly

    2012-03-01

    Type 2 diabetes mellitus is a common metabolism disorder characterized by high glucose in the bloodstream, especially in the case of insulin resistance and relative insulin deficiency. Nowadays, it is very common in middle-aged people and involves such dangerous symptoms as increasing risk of stroke, obesity and heart failure. In Vietnam, besides the common treatment of insulin injection, some herbal medication is used but no unified optimum remedy for the disease yet exists and there is no production of antidiabetic drugs in the domestic market yet. In the development of nanomedicine at the present time, drug design is considered as an innovative tool for researchers to study the mechanisms of diseases at the molecular level. The aim of this article is to review some common protein targets involved in type 2 diabetes, offering a new idea for designing new drug candidates to produce antidiabetic drugs against type 2 diabetes for Vietnamese people.

  10. Targeted proteins for diabetes drug design

    International Nuclear Information System (INIS)

    Trang Nguyen, Ngoc Doan; Le, Ly Thi

    2012-01-01

    Type 2 diabetes mellitus is a common metabolism disorder characterized by high glucose in the bloodstream, especially in the case of insulin resistance and relative insulin deficiency. Nowadays, it is very common in middle-aged people and involves such dangerous symptoms as increasing risk of stroke, obesity and heart failure. In Vietnam, besides the common treatment of insulin injection, some herbal medication is used but no unified optimum remedy for the disease yet exists and there is no production of antidiabetic drugs in the domestic market yet. In the development of nanomedicine at the present time, drug design is considered as an innovative tool for researchers to study the mechanisms of diseases at the molecular level. The aim of this article is to review some common protein targets involved in type 2 diabetes, offering a new idea for designing new drug candidates to produce antidiabetic drugs against type 2 diabetes for Vietnamese people. (review)

  11. Requirements Engineering and Design Technology Report

    National Research Council Canada - National Science Library

    Ganska, Ralph

    1995-01-01

    This report reviews the STSC's recommendations for the selection and usage of software engineering products aimed at the requirements analysis and high-level design portions of the software lifecycle...

  12. Muon-catalyzed fusion experiment target and detector system. Preliminary design report

    International Nuclear Information System (INIS)

    Jones, S.E.; Watts, K.D.; Caffrey, A.J.; Walter, J.B.

    1982-03-01

    We present detailed plans for the target and particle detector systems for the muon-catalyzed fusion experiment. Requirements imposed on the target vessel by experimental conditions and safety considerations are delineated. Preliminary designs for the target vessel capsule and secondary containment vessel have been developed which meet these requirements. In addition, the particle detection system is outlined, including associated fast electronics and on-line data acquisition. Computer programs developed to study the target and detector system designs are described

  13. Safety requirements applicable to the SMART design

    International Nuclear Information System (INIS)

    Seul, Kwang Won; Kim, Wee Kyong; Kim, Hho Jung

    1999-01-01

    The 330 MW thermal power of integral reactor, named SMART (System integrated Modular Advanced ReacTor), is under development at KAERI for seawater desalination application and electricity generation. The final product of nuclear desalination plant (NDP) is electricity and fresh water. Thus, in addition to the protection of the public around the plant facility from the possible release of radioactive materials, the fresh water should be prevented from radioactivity contamination. In this study, to ensure the safety of SMART reactor in the early stage of design development, the safety requirements applicable to the SMART design were investigated, based on the current regulatory requirements for the existing NPPs and the advanced light water reactor (LWR) designs. The interface requirements related to the desalination facility were also investigated, based on the recent IAEA research activities pertaining to the NDP. As a result, it was found that the current regulatory requirements and guidance for the existing NPPs and advanced LWR designs are applicable to the SMART design and its safety evaluation. However, the safety requirements related to the SMART-specific design and the desalination plant are needed to develop in the future to assure the safety of the SMART reactor

  14. Design choices and issues in fixed-target B experiments

    International Nuclear Information System (INIS)

    Camilleri, L.

    1993-01-01

    The main priority of any experiment on B physics in the years to come will be an endeavour to observe CP violation in the B sector. Such measurements imply the following requirements of the experiment. Trigger: a muon trigger will be sensitive to J/ψ reactions and muon tags; an electron trigger will double the number of lepton events; in order to include kaon tags and self-tagging reactions, the experiment must not rely entirely on lepton triggers. Secondary Vertex triggers and hadron p T triggers should be included in order to have the maximum flexibility. Detector: vertex detector; particle identification; good momentum resolution; electromagnetic and hadronic calorimeters; muon detector. In addition the following issues have to be addressed: Collider or fixed-target mode? If fixed target, extracted beam or internal target? If internal target, gas jet or wire target? If a gas jet, hydrogen or a heavy gas? Beam pipe design. Silicon microvertex design and radiation damage. K s 0 decay path. Particle identification. Momentum resolution. Order of detectors. No single method stands out as the open-quotes obvious one.close quotes An extracted beam yields better vertex resolution and an internal target easier triggering. A flexible and diverse triggering scheme is of prime importance in order to be sensitive to as many reactions as possible, the experiment should not be limited to lepton triggers only. Proposed experiments (P867, HERA B) at existing machines will be invaluable for testing new devices and strategies for the LHC and SSC experiments

  15. Designer's requirements for evaluation of sustainability

    DEFF Research Database (Denmark)

    Bey, Niki; Lenau, Torben Anker

    1998-01-01

    Today, sustainability of products is often evaluated on the basis of assessments of their environmental performance. Established means for this purpose are formal Life Cycle Assessment (LCA) methods. Designers have an essential influence on product design and are therefore one target group for life...... cycle-based evaluation methods. However, the application of LCA in the design process, when for example different materials and manufacturing processes have to be selected, is difficult. This is, among other things, because only a few designers have a deeper background in this area and even simplified...... LCAs involve calculations with a relatively high accuracy. Most LCA methods do therefore not qualify as hands-on tool for utilisation by typical designers.In this context, the authors raise the question, whether a largely simplified LCA-method which is exclusively based on energy considerations can...

  16. Requirements on internal targets for the Aladdin storage ring

    International Nuclear Information System (INIS)

    Holt, R.J.

    1984-01-01

    The feasibility of performing electron scattering experiments with polarized targets in electron storage rings is explored by considering an electron-deuteron scattering experiment at the Aladdin storage ring. It is noted that this new method is compatible with recent proposals for linac-stretcher-ring accelerator designs. A new method for producing a polarized hydrogen or deuterium target is proposed and some preliminary results are described. 21 references, 6 figures, 1 table

  17. Change in requirements during the design process

    DEFF Research Database (Denmark)

    Sudin, Mohd Nizam Bin; Ahmed-Kristensen, Saeema

    2011-01-01

    Specification is an integral part of the product development process. Frequently, more than a single version of a specification is produced due to changes in requirements. These changes are often necessary to ensure the scope of the design problem is as clear as possible. However, the negative...... on a pre-defined coding scheme. The results of the study shows that change in requirements were initiated by internal stakeholders through analysis and evaluation activities during the design process, meanwhile external stakeholders were requested changes during the meeting with consultant. All...

  18. Steam generator design requirements for ACR-1000

    International Nuclear Information System (INIS)

    Subash, S.; Hau, K.

    2006-01-01

    Atomic Energy of Canada Limited (AECL) has developed the ACR-1000 (Advanced CANDU Reactor-1000 ) to meet market expectations for enhanced safety of plant operation, high capacity factor, low operating cost, increased operating life, simple component replacement, reduced capital cost, and shorter construction schedule. The ACR-1000 design is based on the use of horizontal fuel channels surrounded by a heavy water moderator, the same feature as in all CANDU reactors. The major innovation in the ACR-1000 is the use of low enriched uranium fuel, and light water as the coolant, which circulates in the fuel channels. This results in a compact reactor core design and a reduction of heavy water inventory, both contributing to a significant decrease in capital cost per MWe produced. The ACR-1000 plant is a two-unit, integrated plant with each unit having a nominal gross output of about 1165 MWe with a net output of approximately 1085 MWe. The plant design is adaptable to a single unit configuration, if required. This paper focuses on the technical considerations that went into developing some of the important design requirements for the steam generators for the ACR-1000 plant and how these requirements are specified in the Technical Specification, which is the governing document for the steam generator (SG) detail design. Layout of these SGs in the plant is briefly described and their impacts on the SG design. (author)

  19. National Ignition Facility system design requirements Laser System SDR002

    International Nuclear Information System (INIS)

    Larson, D.W.; Bowers, J.M.; Bliss, E.S.; Karpenko, V.P.; English, E.

    1996-01-01

    This System Design Requirement document establishes the performance, design, development, and test requirements for the NIP Laser System. The Laser System generates and delivers high-power optical pulses to the target chamber, and is composed of all optical puke creating and transport elements from Puke Generation through Final Optics as well as the special equipment that supports, energizes and controls them. The Laser System consists of the following WBS elements: 1.3 Laser System 1.4 Beam Transport System 1.6 Optical Components 1.7 Laser Control 1.8.7 Final Optics

  20. Review of nuclear piping seismic design requirements

    International Nuclear Information System (INIS)

    Slagis, G.C.; Moore, S.E.

    1994-01-01

    Modern-day nuclear plant piping systems are designed with a large number of seismic supports and snubbers that may be detrimental to plant reliability. Experimental tests have demonstrated the inherent ruggedness of ductile steel piping for seismic loading. Present methods to predict seismic loads on piping are based on linear-elastic analysis methods with low damping. These methods overpredict the seismic response of ductile steel pipe. Section III of the ASME Boiler and Pressure Vessel Code stresses limits for piping systems that are based on considerations of static loads and hence are overly conservative. Appropriate stress limits for seismic loads on piping should be incorporated into the code to allow more flexible piping designs. The existing requirements and methods for seismic design of piping systems, including inherent conservations, are explained to provide a technical foundation for modifications to those requirements. 30 refs., 5 figs., 3 tabs

  1. Advanced Neutron Sources: Plant Design Requirements

    International Nuclear Information System (INIS)

    1990-07-01

    The Advanced Neutron Source (ANS) is a new, world class facility for research using hot, thermal, cold, and ultra-cold neutrons. At the heart of the facility is a 350-MW th , heavy water cooled and moderated reactor. The reactor is housed in a central reactor building, with supporting equipment located in an adjoining reactor support building. An array of cold neutron guides fans out into a large guide hall, housing about 30 neutron research stations. Office, laboratory, and shop facilities are included to provide a complete users facility. The ANS is scheduled to begin operation at the Oak Ridge National Laboratory at the end of the decade. This Plant Design Requirements document defines the plant-level requirements for the design, construction, and operation of the ANS. This document also defines and provides input to the individual System Design Description (SDD) documents. Together, this Plant Design Requirements document and the set of SDD documents will define and control the baseline configuration of the ANS

  2. IMPACT OF ENERGY GROUP STRUCTURE ON NUCLEAR DATA TARGET ACCURACY REQUIREMENTS FOR ADVANCED REACTOR SYSTEMS

    Energy Technology Data Exchange (ETDEWEB)

    G. Palmiotti; M. Salvatores; H. Hiruta

    2011-06-01

    A target accuracy assessment study using both a fine and a broad energy structure has shown that less stringent nuclear data accuracy requirements are needed for the latter energy structure. However, even though a reduction is observed, still the requirements will be very difficult to be met unless integral experiments are also used to reduce nuclear data uncertainties. Target accuracy assessment is the inverse problem of the uncertainty evaluation. To establish priorities and target accuracies on data uncertainty reduction, a formal approach can be adopted by defining target accuracy on design parameters and finding out required accuracy on data in order to meet them. In fact, the unknown uncertainty data requirements can be obtained by solving a minimization problem where the sensitivity coefficients in conjunction with the constraints on the integral parameters provide the needed quantities for finding the solutions.

  3. Application of analytical target cascading method in multidisciplinary design optimization of ship conceptual design

    Directory of Open Access Journals (Sweden)

    WANG Jian

    2017-10-01

    Full Text Available [Objectives] Ship conceptual design requires the coordination of many different disciplines for comprehensive optimization, which presents a complicated system design problem affecting several fields of technology. However, the development of overall ship design is relatively slow compared with other subjects. [Methods] The decomposition and coordination strategy of ship design is presented, and the analytical target cascading (ATC method is applied to the multidisciplinary design optimization of the conceptual design phase of ships on this basis. A tank ship example covering the 5 disciplines of buoyancy and stability, rapidity, maneuverability, capacity and economy is established to illustrate the analysis process in the present study. [Results] The results demonstrate the stability, convergence and validity of the ATC method in dealing with the complex coupling effect occurring in ship conceptual design.[Conclusions] The proposed method provides an effective basis for optimization of ship conceptual design.

  4. Design requirements for the SWIFT instrument

    International Nuclear Information System (INIS)

    Rahnama, P; McDade, I; Shepherd, G; Gault, W

    2013-01-01

    The Stratospheric Wind Interferometer for Transport studies (SWIFT) instrument is a proposed limb-viewing satellite instrument that employs the method of Doppler Michelson interferometry to measure stratospheric wind velocities and ozone densities in the altitude range of 15–45 km. The values of the main instrument parameters including filter system parameters and Michelson interferometer parameters are derived using simulations and analyses. The system design requirements for the instrument and spacecraft are presented and discussed. Some of the retrieval-imposed design requirements are also discussed. Critical design issues are identified. The design optimization process is described. The sensitivity of wind measurements to instrument characteristics is investigated including the impact on critical design issues. Using sensitivity analyses, the instrument parameters were iteratively optimized in order to meet the science objectives. It is shown that wind measurements are sensitive to the thermal sensitivity of the instrument components, especially the narrow filter and the Michelson interferometer. The optimized values of the main system parameters including Michelson interferometer optical path difference, instrument visibility, instrument responsivity and knowledge of spacecraft velocity are reported. This work also shows that the filter thermal drift and the Michelson thermal drift are two main technical risks. (paper)

  5. Test design requirements for overcoring stress measurements

    International Nuclear Information System (INIS)

    Stickney, R.G.

    1985-12-01

    This document establishes the test design requirements for a series of overcoring stress measurements to be performed in the Exploratory Shaft Facility. The stress measurements will be made to determine the in situ state of stress within the candidate repository horizon and to determine the magnitude and distribution of the stresses induced by the mined openings of the facility. The overcoring technique involves the measurement of strain (or deformation) in a volume of rock as the stress acting on the rock volume is relieved. This document presents an overview of the measurements, including objectives and rationale for the measurements. A description of the measurements is included. The support requirements are identified as are constraints for the design of the measurements. Discussions on Quality Assurance and Safety are also included in the document. 13 refs

  6. Basic design requirements for indigenous irradiator

    International Nuclear Information System (INIS)

    Anwar Abd Rahman; Rosli Darmawan; Mohd Arif Hamzah; Fadil Ismail; Muhd Nor Atan

    2007-01-01

    Most of the irradiators owned by Nuclear Malaysia are imported from other countries. The irradiators are used for various applications such as Research and Development, agriculture and industry. There is a plan to develop locally made multi-purpose gamma irradiator in 9th Malaysia Plan which equipped with better safety features. This paper will discuss the basic requirements for the design of the irradiator. (Author)

  7. New schools design: Acoustics as main target

    Science.gov (United States)

    Maffei, Luigi; Lembo, Paola

    2005-04-01

    The effects of poor intelligibility and high background noise levels on the cognitive development of school children and on the dissatisfaction of teachers has been largely investigated. National standards have been implemented and attempts to harmonize these standards in international guidelines are ongoing. All these activities have led to the awareness that design of new schools must be centered on the achievement of a good acoustic environment. At this point a strong research effort to study and implement best solutions must be conducted, in collaboration, by architects, acousticians, pedagogues, psychologists, builders and acoustic materials producers. Recently an international competition for the planning of new primary schools in Rome, Italy has been announced. The aim of the competition is to study new architectural and running features of primary schools to obtain, among other parameters such as lighting, low cost energy solutions and air quality, the control of reverberation time, sound insulation and mechanical equipments noise. In these school buildings, as innovative requirement, children must be also able to elaborate interpretative hypothesis of physical phenomena such as sound emission and perception and be aware of their influence on these phenomena. Different possible solutions are presented.

  8. Meeting cross-section requirements for nuclear-energy design

    Energy Technology Data Exchange (ETDEWEB)

    Weisbin, C.R.; de Saussure, G.; Santoro, R.T. (Oak Ridge National Lab., TN (USA)); Gilai, T. (Ben-Gurion Univ. of the Negev, Beersheba (Israel))

    1982-01-01

    Current requirements in cross-section data that are essential to nuclear-energy programmes are summarized and explained and some insight into how these data might be obtained is provided. The six sections of the paper describe: design parameters and target accuracies; data collection, evaluation and analysis; determination of high-accuracy differential nuclear data for technological applications; status of selected evaluated nuclear data; analysis of benchmark testing; identification of important cross sections and inferred needs.

  9. MarFS-Requirements-Design-Configuration-Admin

    Energy Technology Data Exchange (ETDEWEB)

    Kettering, Brett Michael [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Grider, Gary Alan [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-07-08

    This document will be organized into sections that are defined by the requirements for a file system that presents a near-POSIX (Portable Operating System Interface) interface to the user, but whose data is stored in whatever form is most efficient for the type of data being stored. After defining the requirement the design for meeting the requirement will be explained. Finally there will be sections on configuring and administering this file system. More and more, data dominates the computing world. There is a “sea” of data out there in many different formats that needs to be managed and used. “Mar” means “sea” in Spanish. Thus, this product is dubbed MarFS, a file system for a sea of data.

  10. Review of laser mega joule target area: Design and processes

    International Nuclear Information System (INIS)

    Geitzholz, M.; Lanternier, C.

    2006-01-01

    The Laser Mega Joule (LMJ) target area is currently designed to achieve ignition and significant fusion gain in laboratory. LMJ will be composed of 240 identical large 370 mm * 370 mm square laser beams. These beams will focus 2 mega-joules of energy at the wavelength of 351 nm on the center of an experiment chamber. Design studies for target equipment are well advanced, target chamber and target holder (concrete) works have already begun. A detailed overview of the target area equipment is presented: target chamber, frame, diagnostic inserter manipulator, final optic assembly, dual diagnostic and laser reference, non cryogenic target positioner. Recent technical and architectural choices are detailed including safety transfers and alignment processes (target, laser and diagnostic). All this target equipment allows us to optimize shot chrono-gram, from target metrology to the shot, including calibration process. (authors)

  11. Basic Block of Pipelined ADC Design Requirements

    Directory of Open Access Journals (Sweden)

    V. Kledrowetz

    2011-04-01

    Full Text Available The paper describes design requirements of a basic stage (called MDAC - Multiplying Digital-to- Analog Converter of a pipelined ADC. There exist error sources such as finite DC gain of opamp, capacitor mismatch, thermal noise, etc., arising when the switched capacitor (SC technique and CMOS technology are used. These non-idealities are explained and their influences on overall parameters of a pipelined ADC are studied. The pipelined ADC including non-idealities was modeled in MATLAB - Simulink simulation environment.

  12. Requirements and Designs for Mars Rover RTGs

    Energy Technology Data Exchange (ETDEWEB)

    Schock, Alfred; Shirbacheh, M; Sankarankandath, V

    2012-01-19

    The current-generation RTGs (both GPHS and MOD) are designed for operation in a vacuum environment. The multifoil thermal insulation used in those RTGs only functions well in a good vacuum. Current RTGs are designed to operate with an inert cover gas before launch, and to be vented to space vacuum after launch. Both RTGs are sealed with a large number of metallic C-rings. Those seals are adequate for retaining the inert-gas overpressure during short-term launch operations, but would not be adequate to prevent intrusion of the Martian atmospheric gases during long-term operations there. Therefore, for the Mars Rover application, those RTGs just be modified to prevent the buildup of significant pressures of Mars atmosphere or of helium (from alpha decay of the fuel). In addition, a Mars Rover RTG needs to withstand a long-term dynamic environment that is much more severe than that seen by an RTG on an orbiting spacecraft or on a stationary planetary lander. This paper describes a typical Rover mission, its requirements, the environment it imposes on the RTG, and a design approach for making the RTG operable in such an environment. Specific RTG designs for various thermoelectric element alternatives are presented.; Reference CID #9268 and CID #9276.

  13. ALS beamline design requirements: A guide for beamline designers

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-06-01

    This manual is written as a guide for researchers in designing beamlines and endstations acceptable for use at the ALS. It contains guidelines and policies related to personnel safety and equipment and vacuum protection. All equipment and procedures must ultimately satisfy the safety requirements set aside in the Lawrence Berkeley National Laboratory (LBNL) Health and Safety Manual (PUB-3000) which is available from the ALS User Office or on the World WideWeb from the LBNL Homepage (http:// www.lbl.gov).

  14. Design of the Next Generation Spallation Target

    Energy Technology Data Exchange (ETDEWEB)

    Ferres, Laurent [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-06-13

    The purpose of this summary is to detail the studies that enable new nuclear physics experiments currently limited by neutron intensity or energy resolution available at LANSCE. The target is being redesigned so that the Flight Paths (FP) in the upper tier provide a higher intensity in the epithermal and medium energy ranges.

  15. Directions for reactor target design based on the US heavy ion fusion systems assessment

    International Nuclear Information System (INIS)

    Wilson, D.C.; Dudziak, D.; Magelssen, G.; Zuckerman, D.; Dreimeyer, D.

    1986-01-01

    We studied areas of major uncertainty in target design using the cost of electricity as our figure of merit. Net electric power from the plant was fixed at 1000 MW to eliminate large effects due to economies of scale. The system is relatively insensitive to target gain. Factors of three changes in gain cause only 8 to 12% changes in electricity cost. An increase in the peak power needed to drive targets poses only a small cost risk, but requires many more beamlets be transported to the target. A shortening of the required ion range causes both cost and beamlet difficulties. A factor of 4 decrease in the required range at a fixed driver energy increases electricity cost by 44% and raises the number of beamlets to 240. Finally, the heavy ion fusion system can accommodate large increases in target costs. To address the major uncertainties, target design should concentrate on the understanding requirements for ion range and peak driver power

  16. Designing high power targets with computational fluid dynamics (CFD)

    International Nuclear Information System (INIS)

    Covrig, S. D.

    2013-01-01

    High power liquid hydrogen (LH2) targets, up to 850 W, have been widely used at Jefferson Lab for the 6 GeV physics program. The typical luminosity loss of a 20 cm long LH2 target was 20% for a beam current of 100 μA rastered on a square of side 2 mm on the target. The 35 cm long, 2500 W LH2 target for the Qweak experiment had a luminosity loss of 0.8% at 180 μA beam rastered on a square of side 4 mm at the target. The Qweak target was the highest power liquid hydrogen target in the world and with the lowest noise figure. The Qweak target was the first one designed with CFD at Jefferson Lab. A CFD facility is being established at Jefferson Lab to design, build and test a new generation of low noise high power targets

  17. Designing high power targets with computational fluid dynamics (CFD)

    Energy Technology Data Exchange (ETDEWEB)

    Covrig, S. D. [Thomas Jefferson National Laboratory, Newport News, VA 23606 (United States)

    2013-11-07

    High power liquid hydrogen (LH2) targets, up to 850 W, have been widely used at Jefferson Lab for the 6 GeV physics program. The typical luminosity loss of a 20 cm long LH2 target was 20% for a beam current of 100 μA rastered on a square of side 2 mm on the target. The 35 cm long, 2500 W LH2 target for the Qweak experiment had a luminosity loss of 0.8% at 180 μA beam rastered on a square of side 4 mm at the target. The Qweak target was the highest power liquid hydrogen target in the world and with the lowest noise figure. The Qweak target was the first one designed with CFD at Jefferson Lab. A CFD facility is being established at Jefferson Lab to design, build and test a new generation of low noise high power targets.

  18. Economic targets for small PWR reactor designs

    International Nuclear Information System (INIS)

    Board, J.

    1991-01-01

    Small reactors are likely to be less economic than large reactors, but the lower financial exposure with small reactors may be attractive to utilities contemplating a restart to a nuclear programme. New nuclear plant can be economic, but success will depend more on how the plant are built, rather than what type or size is built. A target for new plant for operation early in the next century should be a generation cost of 3p to 3.5 p/kWh. This corresponds to an overnight capital cost of Pound 1000/kWh to Pound 1100/kWh. (author)

  19. NIF Ignition Target 3D Point Design

    Energy Technology Data Exchange (ETDEWEB)

    Jones, O; Marinak, M; Milovich, J; Callahan, D

    2008-11-05

    We have developed an input file for running 3D NIF hohlraums that is optimized such that it can be run in 1-2 days on parallel computers. We have incorporated increasing levels of automation into the 3D input file: (1) Configuration controlled input files; (2) Common file for 2D and 3D, different types of capsules (symcap, etc.); and (3) Can obtain target dimensions, laser pulse, and diagnostics settings automatically from NIF Campaign Management Tool. Using 3D Hydra calculations to investigate different problems: (1) Intrinsic 3D asymmetry; (2) Tolerance to nonideal 3D effects (e.g. laser power balance, pointing errors); and (3) Synthetic diagnostics.

  20. Design Requirements for Designing Responsive Modular Manufacturing Systems

    DEFF Research Database (Denmark)

    Jørgensen, Steffen; Madsen, Ole; Nielsen, Kjeld

    2011-01-01

    Customers demand the newest technologies, newest designs, the ability to customise, high quality, and all this at a low cost. These are trends which challenge the traditional way of operating manufacturing companies, especially in regard to product development and manufacturing. Research...... the needed flexibility and responsiveness, but such systems are not yet fully achieved. From related theory it is known that achieving modular benefits depend on the modular architecture; a modular architecture which must be developed according to the customer needs. This makes production needs a design...... requirement in order to achieve responsiveness and other benefits of modular manufacturing systems (MMS). Due to the complex and interrelated nature of a production system and its surroundings these production needs are complex to identify. This paper presents an analysis framework for identification...

  1. Advanced Neutron Source: Plant Design Requirements

    International Nuclear Information System (INIS)

    1990-07-01

    The Advanced Neutron Source will be a new world-class facility for research using hot, thermal, cold, and ultra-cold neutrons. The heart of the facility will be a 330-MW (fission), heavy-water cooled and heavy-water moderated reactor. The reactor will be housed in a central reactor building, with supporting equipment located in an adjoining reactor support building. An array of cold neutron guides will fan out into a large guide hall, housing about 30 neutron research stations. Appropriate office, laboratory, and shop facilities will be included to provide a complete facility for users. The ANS is scheduled to begin operation at the Oak Ridge National Laboratory early in the next decade. This PDR document defines the plant-level requirements for the design, construction, and operation of ANS. It also defines and provides input to the individual System Design Description (SDD) documents. Together, this PDR document and the set of SDD documents will define and control the baseline configuration of ANS

  2. The design, construction and performance of the MICE target

    International Nuclear Information System (INIS)

    Booth, C N; Hodgson, P; Howlett, L; Nicholson, R; Overton, E; Robinson, M; Smith, P J; Apollonio, M; Barber, G; Dobbs, A; Leaver, J; Long, K R; Shepherd, B; Adams, D; Capocci, E; McCarron, E; Tarrant, J

    2013-01-01

    The pion-production target that serves the MICE Muon Beam consists of a titanium cylinder that is dipped into the halo of the ISIS proton beam. The design and construction of the MICE target system are described along with the quality-assurance procedures, electromagnetic drive and control systems, the readout electronics, and the data-acquisition system. The performance of the target is presented together with the particle rates delivered to the MICE Muon Beam. Finally, the beam loss in ISIS generated by the operation of the target is evaluated as a function of the particle rate, and the operating parameters of the target are derived.

  3. Adaptive Waveform Design for Cognitive Radar in Multiple Targets Situations

    Directory of Open Access Journals (Sweden)

    Xiaowen Zhang

    2018-02-01

    Full Text Available In this paper, the problem of cognitive radar (CR waveform optimization design for target detection and estimation in multiple extended targets situations is investigated. This problem is analyzed in signal-dependent interference, as well as additive channel noise for extended targets with unknown target impulse response (TIR. To address this problem, an improved algorithm is employed for target detection by maximizing the detection probability of the received echo on the promise of ensuring the TIR estimation precision. In this algorithm, an additional weight vector is introduced to achieve a trade-off among different targets. Both the estimate of TIR and transmit waveform can be updated at each step based on the previous step. Under the same constraint on waveform energy and bandwidth, the information theoretical approach is also considered. In addition, the relationship between the waveforms that are designed based on the two criteria is discussed. Unlike most existing works that only consider single target with temporally correlated characteristics, waveform design for multiple extended targets is considered in this method. Simulation results demonstrate that compared with linear frequency modulated (LFM signal, waveforms designed based on maximum detection probability and maximum mutual information (MI criteria can make radar echoes contain more multiple-target information and improve radar performance as a result.

  4. Target based drug design - a reality in virtual sphere.

    Science.gov (United States)

    Verma, Saroj; Prabhakar, Yenamandra S

    2015-01-01

    The target based drug design approaches are a series of computational procedures, including visualization tools, to support the decision systems of drug design/discovery process. In the essence of biological targets shaping the potential lead/drug molecules, this review presents a comprehensive position of different components of target based drug design which include target identification, protein modeling, molecular dynamics simulations, binding/catalytic sites identification, docking, virtual screening, fragment based strategies, substructure treatment of targets in tackling drug resistance, in silico ADMET, structural vaccinology, etc along with the key issues involved therein and some well investigated case studies. The concepts and working of these procedures are critically discussed to arouse interest and to advance the drug research.

  5. Design requirement on KALIMER control rod assembly duct

    International Nuclear Information System (INIS)

    Hwang, W.; Kang, H. Y.; Nam, C.; Kim, J. O.; Kim, Y. J.

    1998-03-01

    This document establishes the design guidelines which are needs for designing the control rod assembly duct of the KALIMER as design requirements. it describes control rod assembly duct of the KALIMER and its requirements that includes functional requirements, performance requirements, interfacing systems, design limits and strength requirements, seismic requirements, structural requirements, environmental requirements, reliability and safety requirements, standard and codes, QA programs, and other requirements. The control rod system consists of three parts, which are drive mechanism, drive-line, and absorber bundle. This report deals with the absorber bundle and its outer duct only because the others are beyond the scope of fuel system design. The guidelines for design requirements intend to be used for an improved design of the control rod assembly duct of the KALIMER. (author). 19 refs

  6. Design requirement on KALIMER control rod assembly duct

    Energy Technology Data Exchange (ETDEWEB)

    Hwang, W.; Kang, H. Y.; Nam, C.; Kim, J. O.; Kim, Y. J

    1998-03-01

    This document establishes the design guidelines which are needs for designing the control rod assembly duct of the KALIMER as design requirements. it describes control rod assembly duct of the KALIMER and its requirements that includes functional requirements, performance requirements, interfacing systems, design limits and strength requirements, seismic requirements, structural requirements, environmental requirements, reliability and safety requirements, standard and codes, QA programs, and other requirements. The control rod system consists of three parts, which are drive mechanism, drive-line, and absorber bundle. This report deals with the absorber bundle and its outer duct only because the others are beyond the scope of fuel system design. The guidelines for design requirements intend to be used for an improved design of the control rod assembly duct of the KALIMER. (author). 19 refs.

  7. Design of a cryogenic deuterium gas target for neutron therapy

    International Nuclear Information System (INIS)

    Kuchnir, F.T.; Waterman, F.M.; Forsthoff, H.; Skaggs, L.S.; Vander Arend, P.C.; Stoy, S.

    1976-01-01

    A cryogenic deuterium gas target operating at 80 0 K and 10 atm pressure has been designed for use with a small cyclotron; the D(d,n) reaction is used to produce a neutron beam suitable for radiation therapy. The target is cooled by circulation of the gas in a closed loop between the target and an external heat exchanger immersed in liquid nitrogen

  8. Design and Fabrication of Titanium Target for Portable Neutron Generator

    International Nuclear Information System (INIS)

    Lee, Cheol Ho; Oh, Byunghoon; Chang, Daesik; Jang, Dohyun; In Sang Yeol; Park, Jaewon; Hong, Kwangpyo

    2014-01-01

    For the neutron generator to produce a neutron flux of the above order, a target that produces fast neutrons in the generator plays an important role, and the target is used and applied to develop the generator due to its simplicity and inexpensive. Making suitable targets for neutron production, especially mono-energy neutrons, has always been of interest. These targets have been used for neutron production reaction studies, calibration of detectors, and neutron therapy. Different studies have been carried out on deuterium and tritium for making solid targets to produce mono-energy neutron from D-D and D-T reactions. A lot of investigations have been carried out on solid target properties such as lifetime, thermal stability, neutron yield, and energy. Vaporized zirconium and titanium layers on a high thermal conductivity substrate (Cu, Mo, Ag) have been used as deuterium and tritium absorbing metals. The density of titanium is smaller than zirconium and the range of charged particles in the titanium targets is more than that in zirconium targets. Thus, titanium targets have more neutron yield than zirconium targets in a low energy beam and titanium is usually used to make a target. The titanium target was designed and simulated to determine the suitable thickness of the target. As a result of the simulation, the target was fabricated to generate fast neutrons by the reaction. The thickness of the target was measured using a profiler. The thickness of the two targets is 2.108 and 2.190 μm. The target will be applied to produce neutrons in a neutron generator

  9. A Design Theory for Requirements Mining Systems

    OpenAIRE

    Meth, Hendrik

    2013-01-01

    Software requirements are often communicated in unstructured text documents, which need to be analyzed in order to identify and classify individual needs. This process is referred to as requirements mining in the context of this thesis. It is known to be time-consuming and error-prone when performed manually by a requirements engineer. Thus, there is a demand to support requirements mining through information technology. However, little research has been conducted to conceptualize theoretical...

  10. Optical design of adjustable light emitting diode for different lighting requirements

    International Nuclear Information System (INIS)

    Lu Jia-Ning; Yu Jie; Tong Yu-Zhen; Zhang Guo-Yi

    2012-01-01

    Light emitting diode (LED) sources have been widely used for illumination. Optical design, especially freedom compact lens design is necessary to make LED sources applied in lighting industry, such as large-range interior lighting and small-range condensed lighting. For different lighting requirements, the size of target planes should be variable. In our paper we provide a method to design freedom lens according to the energy conservation law and Snell law through establishing energy mapping between the luminous flux emitted by a Lambertian LED source and a certain area of the target plane. The algorithm of our design can easily change the radius of each circular target plane, which makes the size of the target plane adjustable. Ray-tracing software Tracepro is used to validate the illuminance maps and polar-distribution maps. We design lenses for different sizes of target planes to meet specific lighting requirements. (condensed matter: electronic structure, electrical, magnetic, and optical properties)

  11. A closed-loop based framework for design requirement management

    DEFF Research Database (Denmark)

    Zhang, Zhinan; Li, Xuemeng; Liu, Zelin

    2014-01-01

    management from product lifecycle, and requirement and requirement management lifecycle views. This paper highlights the importance of requirement lifecycle management and aims at closing the requirement information loop in product lifecycle. Then, it addresses the requirement management in engineering...... design field with focusing on the dynamics nature and incomplete nature of requirements. Finally, a closed-loop based framework is proposed for requirement management in engineering design....

  12. Design of ignition targets for the National Ignition Facility

    International Nuclear Information System (INIS)

    Haan, S.W.; Dittrich, T.R.; Marinak, M.M.; Hinkel, D.E.

    1999-01-01

    This is a brief update on the work being done to design ignition targets for the National Ignition Facility. Updates are presented on three areas of current activity : improvements in modeling, work on a variety of targets spanning the parameter space of possible ignition targets ; and the setting of specifications for target fabrication and diagnostics. Highlights of recent activity include : a simulation of the Rayleigh-Taylor instability growth on an imploding capsule, done in 3D on a 72degree by 72degree wedge, with enough zones to resolve modes out to 100 ; and designs of targets at 250eV and 350eV, as well as the baseline 300 eV ; and variation of the central DT gas density, which influences both the Rayleigh-Taylor growth and the smoothness of the DT ice layer

  13. Design study of ITER-like divertor target for DEMO

    International Nuclear Information System (INIS)

    Crescenzi, Fabio; Bachmann, C.; Richou, M.; Roccella, S.; Visca, E.; You, J.-H.

    2015-01-01

    Highlights: • ‘DEMO’ is a near-term Power Plant Conceptual Study (PPCS). • The ITER-like design concept represents a promising solution also for DEMO plasma facing units. • The optimization of PFUs aims to enhance the thermo-mechanical behaviour of the component. • The optimized geometry was evaluated by ITER SDC-IC criteria and in terms of low cycle fatigue (LCF). - Abstract: A near-term water-cooled target solution has to be evaluated together with the required technologies and its power exhaust limit under ‘DEMO’ conditions. The ITER-like design concept based on the mono-block technology using W as armour material and the CuCrZr-IG as structural material with an interlayer of pure copper represents a promising solution also for DEMO. This work reports the design study of an “optimized” ITER-like Water Cooled Divertor able to withstand a heat flux of 10 MW m"−"2, as requested for DEMO operating conditions. The optimization of plasma facing unit (PFU) aims to enhance the thermo-mechanical behaviour of the component by varying some geometrical parameters (monoblock size, interlayer thickness and, tube diameter and thickness). The optimization was performed by means of the multi-variable optimization algorithms using the FEM code ANSYS. The coolant hydraulic conditions (inlet pressure, temperature and velocity) were fixed for simplicity. This study is based on elastic analysis and 3 dimensional modelling. The resulting optimized geometry was evaluated on the basis of the ITER SDC-IC criteria and in terms of low cycle fatigue (LCF). The margin to the critical heat flux (CHF) was also estimated. Further design study (taking into account the effect of neutron radiation on the material properties) together with mock-up fabrication and high-heat-flux (HHF) tests are foreseen in next work programmes.

  14. Design study of ITER-like divertor target for DEMO

    Energy Technology Data Exchange (ETDEWEB)

    Crescenzi, Fabio, E-mail: fabio.crescenzi@enea.it [ENEA, Unità Tecnica Fusione, ENEA C. R. Frascati, via E. Fermi 45, 00044 Frascati (Roma) (Italy); Bachmann, C. [EFDA, Power Plant Physics and Technology, Boltzmannstraße 2, 85748 Garching (Germany); Richou, M. [CEA, IRFM, F-13108 Saint Paul Lez Durance (France); Roccella, S.; Visca, E. [ENEA, Unità Tecnica Fusione, ENEA C. R. Frascati, via E. Fermi 45, 00044 Frascati (Roma) (Italy); You, J.-H. [Max-Planck-Institut für Plasmaphysik, Boltzmannstr. 2, 85748 Garching (Germany)

    2015-10-15

    Highlights: • ‘DEMO’ is a near-term Power Plant Conceptual Study (PPCS). • The ITER-like design concept represents a promising solution also for DEMO plasma facing units. • The optimization of PFUs aims to enhance the thermo-mechanical behaviour of the component. • The optimized geometry was evaluated by ITER SDC-IC criteria and in terms of low cycle fatigue (LCF). - Abstract: A near-term water-cooled target solution has to be evaluated together with the required technologies and its power exhaust limit under ‘DEMO’ conditions. The ITER-like design concept based on the mono-block technology using W as armour material and the CuCrZr-IG as structural material with an interlayer of pure copper represents a promising solution also for DEMO. This work reports the design study of an “optimized” ITER-like Water Cooled Divertor able to withstand a heat flux of 10 MW m{sup −2}, as requested for DEMO operating conditions. The optimization of plasma facing unit (PFU) aims to enhance the thermo-mechanical behaviour of the component by varying some geometrical parameters (monoblock size, interlayer thickness and, tube diameter and thickness). The optimization was performed by means of the multi-variable optimization algorithms using the FEM code ANSYS. The coolant hydraulic conditions (inlet pressure, temperature and velocity) were fixed for simplicity. This study is based on elastic analysis and 3 dimensional modelling. The resulting optimized geometry was evaluated on the basis of the ITER SDC-IC criteria and in terms of low cycle fatigue (LCF). The margin to the critical heat flux (CHF) was also estimated. Further design study (taking into account the effect of neutron radiation on the material properties) together with mock-up fabrication and high-heat-flux (HHF) tests are foreseen in next work programmes.

  15. Defining Requirements and Related Methods for Designing Sensorized Garments

    Directory of Open Access Journals (Sweden)

    Giuseppe Andreoni

    2016-05-01

    Full Text Available Designing smart garments has strong interdisciplinary implications, specifically related to user and technical requirements, but also because of the very different applications they have: medicine, sport and fitness, lifestyle monitoring, workplace and job conditions analysis, etc. This paper aims to discuss some user, textile, and technical issues to be faced in sensorized clothes development. In relation to the user, the main requirements are anthropometric, gender-related, and aesthetical. In terms of these requirements, the user’s age, the target application, and fashion trends cannot be ignored, because they determine the compliance with the wearable system. Regarding textile requirements, functional factors—also influencing user comfort—are elasticity and washability, while more technical properties are the stability of the chemical agents’ effects for preserving the sensors’ efficacy and reliability, and assuring the proper duration of the product for the complete life cycle. From the technical side, the physiological issues are the most important: skin conductance, tolerance, irritation, and the effect of sweat and perspiration are key factors for reliable sensing. Other technical features such as battery size and duration, and the form factor of the sensor collector, should be considered, as they affect aesthetical requirements, which have proven to be crucial, as well as comfort and wearability.

  16. Optimum design of exploding pusher target to produce maximum neutrons

    International Nuclear Information System (INIS)

    Kitagawa, Y.; Miyanaga, N.; Kato, Y.; Nakatsuka, M.; Nishiguchi, A.; Yabe, T.; Yamanaka, C.

    1985-03-01

    Exploding pusher target experiments have been conducted with the 1.052-μm GEKKO MII two-beam glass laser system to design an optimum target, which couples to the incident laser light most effectively to produce the maximum neutrons. Since hot electrons preheat the shell entirely in spite of strongly nonuniform irradiation, a simple model can design the optimum target, of which the shell/fuel interface is accelerated to 0.5 to 0.7 times the initial radius within a laser pulse. A 2-dimensional computer simulation supports this target design. The scaling of the neutron yield N with the laser power P is N ∝ P 2.4±0.4 . (author)

  17. Dead-blow hammer design applied to a calibration target mechanism to dampen excessive rebound

    Science.gov (United States)

    Lim, Brian Y.

    1991-01-01

    An existing rotary electromagnetic driver was specified to be used to deploy and restow a blackbody calibration target inside of a spacecraft infrared science instrument. However, this target was much more massive than any other previously inherited design applications. The target experienced unacceptable bounce when reaching its stops. Without any design modification, the momentum generated by the driver caused the target to bounce back to its starting position. Initially, elastomeric dampers were used between the driver and the target. However, this design could not prevent the bounce, and it compromised the positional accuracy of the calibration target. A design that successfully met all the requirements incorporated a sealed pocket 85 percent full of 0.75 mm diameter stainless steel balls in the back of the target to provide the effect of a dead-blow hammer. The energy dissipation resulting from the collision of balls in the pocket successfully dampened the excess momentum generated during the target deployment. The disastrous effects of new requirements on a design with a successful flight history, the modifications that were necessary to make the device work, and the tests performed to verify its functionality are described.

  18. Design and Characterization of High Power Targets for RIB Generation

    International Nuclear Information System (INIS)

    Zhang, Y.

    2001-01-01

    In this article, thermal modeling techniques are used to simulate ISOL targets irradiated with high power proton beams. Beam scattering effects, nuclear reactions and beam power deposition distributions in the target were computed with the Monte Carlo simulation code, GEANT4. The power density information was subsequently used as input to the finite element thermal analysis code, ANSYS, for extracting temperature distribution information for a variety of target materials. The principal objective of the studies was to evaluate techniques for more uniformly distributing beam deposited heat over the volumes of targets to levels compatible with their irradiation with the highest practical primary-beam power, and to use the preferred technique to design high power ISOL targets. The results suggest that radiation cooling, in combination, with primary beam manipulation, can be used to control temperatures in practically sized targets, to levels commensurate with irradiation with 1 GeV, 100 kW proton beams

  19. Test Information Targeting Strategies for Adaptive Multistage Testing Designs.

    Science.gov (United States)

    Luecht, Richard M.; Burgin, William

    Adaptive multistage testlet (MST) designs appear to be gaining popularity for many large-scale computer-based testing programs. These adaptive MST designs use a modularized configuration of preconstructed testlets and embedded score-routing schemes to prepackage different forms of an adaptive test. The conditional information targeting (CIT)…

  20. Water-cooled target-box design at LAMPF

    International Nuclear Information System (INIS)

    Grisham, D.; Lambert, J.

    1983-01-01

    The target boxes in the main experimental beam line (Line A) at the Clinton P. Anderson Meson Physics Facility (LAMPF) have operated since 1976. A program of replacing the boxes is underway. This paper will present past history, design considerations, calculational results and the final box design

  1. Preliminary conceptual design of target system. Pt. 1. System configuration

    Energy Technology Data Exchange (ETDEWEB)

    Hino, Ryutaro; Haga, Katsuhiro; Kaminaga, Masanori [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment] [and others

    1997-07-01

    In the 21st century, neutron is expected to play a very important role in the fields of structural biology, nuclear physics, material science if a very high-intensity neutron source will be built because of its superior nature as an probe to investigate material structure and its function. The Japan Atomic Energy Research Institute has launched the Neutron Science Project for construction and utilization of a high-intensity spallation neutron source coupled with a proton accelerator. In the project, a neutron scattering facility is planned to be constructed in an early stage. Development of a 5MW spallation neutron source is one of the most difficult technical challenges in this project. A two-step development plan of the target was established to construct a 5MW-target station In the 1st step, a 1.5MW target will be constructed to develop 5MW target technology. The preliminary conceptual design was conducted to clarify the specifications of the target system of 1.5MW and 5MW including system layout, scale etc. This report describes (1) a design policy, (2) a layout of system consisting of the target, remote-handling devices, bio-shieldings etc., (3) specifications of components and facilities such as cooling systems for target and moderators, beam-port shutter and air conditioning system, (4) overhaul procedures by remote-handling devices, (5) safety assessment, and (6) necessary R and D items derived from the design activity. (author)

  2. The Sources and Methods of Engineering Design Requirement

    DEFF Research Database (Denmark)

    Li, Xuemeng; Zhang, Zhinan; Ahmed-Kristensen, Saeema

    2014-01-01

    to be defined in a new context. This paper focuses on understanding the design requirement sources at the requirement elicitation phase. It aims at proposing an improved design requirement source classification considering emerging markets and presenting current methods for eliciting requirement for each source...

  3. Knowledge-based support system for requirement elaboration in design

    International Nuclear Information System (INIS)

    Furuta, Kazuo; Kondo, Shunsuke

    1994-01-01

    Design requirements are the seeds of every design activity, but elicitation and formalization of them are not easy tasks. This paper proposes a method to support designers in such requirement elaboration process with a computer. In this method the cognitive work space of designers is modeled by abstraction and structural hierarchies, and supporting functions of knowledge-based requirement elaboration, requirement classification and assessment of contentment status of requirements are provided on this framework. A prototype system was developed and tested using fast breeder reactor design. (author)

  4. Safety of Nuclear Power Plants: Design. Specific Safety Requirements

    International Nuclear Information System (INIS)

    2012-01-01

    On the basis of the principles included in the Fundamental Safety Principles, IAEA Safety Standards Series No. SF-1, this Safety Requirements publication establishes requirements applicable to the design of nuclear power plants. It covers the design phase and provides input for the safe operation of the power plant. It elaborates on the safety objective, safety principles and concepts that provide the basis for deriving the safety requirements that must be met for the design of a nuclear power plant. Contents: 1. Introduction; 2. Applying the safety principles and concepts; 3. Management of safety in design; 4. Principal technical requirements; 5. General plant design; 6. Design of specific plant systems.

  5. Colocated MIMO Radar: Beamforming, Waveform design, and Target Parameter Estimation

    KAUST Repository

    Jardak, Seifallah

    2014-04-01

    Thanks to its improved capabilities, the Multiple Input Multiple Output (MIMO) radar is attracting the attention of researchers and practitioners alike. Because it transmits orthogonal or partially correlated waveforms, this emerging technology outperformed the phased array radar by providing better parametric identifiability, achieving higher spatial resolution, and designing complex beampatterns. To avoid jamming and enhance the signal to noise ratio, it is often interesting to maximize the transmitted power in a given region of interest and minimize it elsewhere. This problem is known as the transmit beampattern design and is usually tackled as a two-step process: a transmit covariance matrix is firstly designed by minimizing a convex optimization problem, which is then used to generate practical waveforms. In this work, we propose simple novel methods to generate correlated waveforms using finite alphabet constant and non-constant-envelope symbols. To generate finite alphabet waveforms, the proposed method maps easily generated Gaussian random variables onto the phase-shift-keying, pulse-amplitude, and quadrature-amplitude modulation schemes. For such mapping, the probability density function of Gaussian random variables is divided into M regions, where M is the number of alphabets in the corresponding modulation scheme. By exploiting the mapping function, the relationship between the cross-correlation of Gaussian and finite alphabet symbols is derived. The second part of this thesis covers the topic of target parameter estimation. To determine the reflection coefficient, spatial location, and Doppler shift of a target, maximum likelihood estimation yields the best performance. However, it requires a two dimensional search problem. Therefore, its computational complexity is prohibitively high. So, we proposed a reduced complexity and optimum performance algorithm which allows the two dimensional fast Fourier transform to jointly estimate the spatial location

  6. Designer interface peptide grafts target estrogen receptor alpha dimerization

    International Nuclear Information System (INIS)

    Chakraborty, S.; Asare, B.K.; Biswas, P.K.; Rajnarayanan, R.V.

    2016-01-01

    The nuclear transcription factor estrogen receptor alpha (ERα), triggered by its cognate ligand estrogen, regulates a variety of cellular signaling events. ERα is expressed in 70% of breast cancers and is a widely validated target for anti-breast cancer drug discovery. Administration of anti-estrogen to block estrogen receptor activation is still a viable anti-breast cancer treatment option but anti-estrogen resistance has been a significant bottle-neck. Dimerization of estrogen receptor is required for ER activation. Blocking ERα dimerization is therefore a complementary and alternative strategy to combat anti-estrogen resistance. Dimer interface peptide “I-box” derived from ER residues 503–518 specifically blocks ER dimerization. Recently using a comprehensive molecular simulation we studied the interaction dynamics of ERα LBDs in a homo-dimer. Based on this study, we identified three interface recognition peptide motifs LDKITDT (ERα residues 479–485), LQQQHQRLAQ (residues 497–506), and LSHIRHMSNK (residues 511–520) and reported the suitability of using LQQQHQRLAQ (ER 497–506) as a template to design inhibitors of ERα dimerization. Stability and self-aggregation of peptide based therapeutics poses a significant bottle-neck to proceed further. In this study utilizing peptide grafted to preserve their pharmacophoric recognition motif and assessed their stability and potential to block ERα mediated activity in silico and in vitro. The Grafted peptides blocked ERα mediated cell proliferation and viability of breast cancer cells but did not alter their apoptotic fate. We believe the structural clues identified in this study can be used to identify novel peptidometics and small molecules that specifically target ER dimer interface generating a new breed of anti-cancer agents. - Highlights: • Designer peptide grafts retain core molecular recognition motif during MD simulations. • Designer peptide grafts with Poly-ALA helix form stable

  7. Designer interface peptide grafts target estrogen receptor alpha dimerization

    Energy Technology Data Exchange (ETDEWEB)

    Chakraborty, S. [Laboratory of Computational Biophysics & Bioengineering, Department of Physics, Tougaloo College, Tougaloo, MS 39174 (United States); Asare, B.K. [Department of Pharmacology and Toxicology, University of Buffalo, Buffalo, NY 14214 (United States); Biswas, P.K., E-mail: pbiswas@tougaloo.edu [Laboratory of Computational Biophysics & Bioengineering, Department of Physics, Tougaloo College, Tougaloo, MS 39174 (United States); Rajnarayanan, R.V., E-mail: rajendra@buffalo.edu [Department of Pharmacology and Toxicology, University of Buffalo, Buffalo, NY 14214 (United States)

    2016-09-09

    The nuclear transcription factor estrogen receptor alpha (ERα), triggered by its cognate ligand estrogen, regulates a variety of cellular signaling events. ERα is expressed in 70% of breast cancers and is a widely validated target for anti-breast cancer drug discovery. Administration of anti-estrogen to block estrogen receptor activation is still a viable anti-breast cancer treatment option but anti-estrogen resistance has been a significant bottle-neck. Dimerization of estrogen receptor is required for ER activation. Blocking ERα dimerization is therefore a complementary and alternative strategy to combat anti-estrogen resistance. Dimer interface peptide “I-box” derived from ER residues 503–518 specifically blocks ER dimerization. Recently using a comprehensive molecular simulation we studied the interaction dynamics of ERα LBDs in a homo-dimer. Based on this study, we identified three interface recognition peptide motifs LDKITDT (ERα residues 479–485), LQQQHQRLAQ (residues 497–506), and LSHIRHMSNK (residues 511–520) and reported the suitability of using LQQQHQRLAQ (ER 497–506) as a template to design inhibitors of ERα dimerization. Stability and self-aggregation of peptide based therapeutics poses a significant bottle-neck to proceed further. In this study utilizing peptide grafted to preserve their pharmacophoric recognition motif and assessed their stability and potential to block ERα mediated activity in silico and in vitro. The Grafted peptides blocked ERα mediated cell proliferation and viability of breast cancer cells but did not alter their apoptotic fate. We believe the structural clues identified in this study can be used to identify novel peptidometics and small molecules that specifically target ER dimer interface generating a new breed of anti-cancer agents. - Highlights: • Designer peptide grafts retain core molecular recognition motif during MD simulations. • Designer peptide grafts with Poly-ALA helix form stable

  8. Computational design of high efficiency release targets for use at ISOL facilities

    CERN Document Server

    Liu, Y

    1999-01-01

    This report describes efforts made at the Oak Ridge National Laboratory to design high-efficiency-release targets that simultaneously incorporate the short diffusion lengths, high permeabilities, controllable temperatures, and heat-removal properties required for the generation of useful radioactive ion beam (RIB) intensities for nuclear physics and astrophysics research using the isotope separation on-line (ISOL) technique. Short diffusion lengths are achieved either by using thin fibrous target materials or by coating thin layers of selected target material onto low-density carbon fibers such as reticulated-vitreous-carbon fiber (RVCF) or carbon-bonded-carbon fiber (CBCF) to form highly permeable composite target matrices. Computational studies that simulate the generation and removal of primary beam deposited heat from target materials have been conducted to optimize the design of target/heat-sink systems for generating RIBs. The results derived from diffusion release-rate simulation studies for selected t...

  9. Design of a covert RFID tag network for target discovery and target information routing.

    Science.gov (United States)

    Pan, Qihe; Narayanan, Ram M

    2011-01-01

    Radio frequency identification (RFID) tags are small electronic devices working in the radio frequency range. They use wireless radio communications to automatically identify objects or people without the need for line-of-sight or contact, and are widely used in inventory tracking, object location, environmental monitoring. This paper presents a design of a covert RFID tag network for target discovery and target information routing. In the design, a static or very slowly moving target in the field of RFID tags transmits a distinct pseudo-noise signal, and the RFID tags in the network collect the target information and route it to the command center. A map of each RFID tag's location is saved at command center, which can determine where a RFID tag is located based on each RFID tag's ID. We propose the target information collection method with target association and clustering, and we also propose the information routing algorithm within the RFID tag network. The design and operation of the proposed algorithms are illustrated through examples. Simulation results demonstrate the effectiveness of the design.

  10. Shortening User Interface Design Iterations through Realtime Visualisation of Design Actions on the Target Device

    OpenAIRE

    MESKENS, Jan; LUYTEN, Kris; CONINX, Karin

    2009-01-01

    In current mobile user interface design tools, it is time consuming to export a design to the target device. This makes it hard for designers to iterate over the user interfaces they are creating. We propose Gummy-live, a GUI builder for mobile devices allowing designers to test and observe immediately on the target device each step they take in the GUI builder. This way, designers are stimulated to iteratively test and refine user interface prototypes in order to take the target device charac...

  11. Simulation Data Management - Requirements and Design Specification

    Energy Technology Data Exchange (ETDEWEB)

    Clay, Robert L. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Friedman-Hill, Ernest J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Gibson, Marcus J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Hoffman, Edward L. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Olson, Kevin H. [Science Applications International Corporation (SAIC), Reston, VA (United States); Laney, Daniel [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2017-11-01

    Simulation Data Management (SDM), the ability to securely organize, archive, and share analysis models and the artifacts used to create them, is a fundamental requirement for modern engineering analysis based on computational simulation. We have worked separately to provide secure, network SDM services to engineers and scientists at our respective laboratories for over a decade. We propose to leverage our experience and lessons learned to help develop and deploy a next-generation SDM service as part of a multi-laboratory team. This service will be portable across multiple sites and platforms, and will be accessible via a range of command-line tools and well-documented APIs. In this document, we’ll review our high-level and low-level requirements for such a system, review one existing system, and briefly discuss our proposed implementation.

  12. Quantifying design trade-offs of beryllium targets on NIF

    Science.gov (United States)

    Yi, S. A.; Zylstra, A. B.; Kline, J. L.; Loomis, E. N.; Kyrala, G. A.; Shah, R. C.; Perry, T. S.; Kanzleiter, R. J.; Batha, S. H.; MacLaren, S. A.; Ralph, J. E.; Masse, L. P.; Salmonson, J. D.; Tipton, R. E.; Callahan, D. A.; Hurricane, O. A.

    2017-10-01

    An important determinant of target performance is implosion kinetic energy, which scales with the capsule size. The maximum achievable performance for a given laser is thus related to the largest capsule that can be imploded symmetrically, constrained by drive uniformity. A limiting factor for symmetric radiation drive is the ratio of hohlraum to capsule radii, or case-to-capsule ratio (CCR). For a fixed laser energy, a larger hohlraum allows for driving bigger capsules symmetrically at the cost of reduced peak radiation temperature (Tr). Beryllium ablators may thus allow for unique target design trade-offs due to their higher ablation efficiency at lower Tr. By utilizing larger hohlraum sizes than most modern NIF designs, beryllium capsules thus have the potential to operate in unique regions of the target design parameter space. We present design simulations of beryllium targets with a large CCR = 4.3 3.7 . These are scaled surrogates of large hohlraum low Tr beryllium targets, with the goal of quantifying symmetry tunability as a function of CCR. This work performed under the auspices of the U.S. DOE by LANL under contract DE-AC52- 06NA25396, and by LLNL under Contract DE-AC52-07NA27344.

  13. Generic study on the design and operation of high power targets

    Directory of Open Access Journals (Sweden)

    A. Ahmad

    2014-02-01

    Full Text Available With the move towards beam power in the range of 1–10 MW, a thorough understanding of the response of target materials and auxiliary systems to high power densities and intense radiation fields is required. This paper provides insight into three major aspects related to the design and operation of high power solid targets: thermal stresses, coolant performance, and radiation damage. Where appropriate, a figure-of-merit approach is followed to facilitate the comparison between different target or coolant candidates. The section on radiation damage reports total and spatial variations of displacement-per-atom and helium production levels in different target materials.

  14. Spectrum analysis on quality requirements consideration in software design documents.

    Science.gov (United States)

    Kaiya, Haruhiko; Umemura, Masahiro; Ogata, Shinpei; Kaijiri, Kenji

    2013-12-01

    Software quality requirements defined in the requirements analysis stage should be implemented in the final products, such as source codes and system deployment. To guarantee this meta-requirement, quality requirements should be considered in the intermediate stages, such as the design stage or the architectural definition stage. We propose a novel method for checking whether quality requirements are considered in the design stage. In this method, a technique called "spectrum analysis for quality requirements" is applied not only to requirements specifications but also to design documents. The technique enables us to derive the spectrum of a document, and quality requirements considerations in the document are numerically represented in the spectrum. We can thus objectively identify whether the considerations of quality requirements in a requirements document are adapted to its design document. To validate the method, we applied it to commercial software systems with the help of a supporting tool, and we confirmed that the method worked well.

  15. Angular glint effects generation for false naval target verisimility requirements

    International Nuclear Information System (INIS)

    Kostis, Theodoros G; Galanis, Konstantinos G; Katsikas, Sokratis K

    2009-01-01

    A stimulating problem in the generation of coherent countermeasures for high range resolution radar systems is the inclusion of angular glint effects in the preparation of the false target mask. Since angular glint is representative of extended naval targets, this inclusion increases the credibility factor of the decoy playback signal at the adversary radar-operator station. In this paper, the ability of an interferometric inverse synthetic aperture radar (InISAR) simulator to provide a proof of concept towards the clarification of this challenging task is ascertained. The solution consists of three novel vector representations of the generated data, which are proven to behave according to the laws of physics governing the glint phenomenon. The first depiction is the angular glint injection at the target which is followed by the representation of the wavefront distortion at the radar. A value-added time procession integration of the target in pure roll motion provides an expected by ISAR theory side-view image of the naval extended false target. The effectiveness of the proposed approach through verification and validation of the results by using the method of pictorial evidence is established. A final argument is raised on the usage of this software tool for actual obfuscation and deception actions for air defence at sea applications

  16. Improving the requirements process in Axiomatic Design Theory

    DEFF Research Database (Denmark)

    Thompson, Mary Kathryn

    2013-01-01

    This paper introduces a model to integrate the traditional requirements process into Axiomatic Design Theory and proposes a method to structure the requirements process. The method includes a requirements classification system to ensure that all requirements information can be included...... in the Axiomatic Design process, a stakeholder classification system to reduce the chances of excluding one or more key stakeholders, and a table to visualize the mapping between the stakeholders and their requirements....

  17. Design and Preliminary Testing of the International Docking Adapter's Peripheral Docking Target

    Science.gov (United States)

    Foster, Christopher W.; Blaschak, Johnathan; Eldridge, Erin A.; Brazzel, Jack P.; Spehar, Peter T.

    2015-01-01

    The International Docking Adapter's Peripheral Docking Target (PDT) was designed to allow a docking spacecraft to judge its alignment relative to the docking system. The PDT was designed to be compatible with relative sensors using visible cameras, thermal imagers, or Light Detection and Ranging (LIDAR) technologies. The conceptual design team tested prototype designs and materials to determine the contrast requirements for the features. This paper will discuss the design of the PDT, the methodology and results of the tests, and the conclusions pertaining to PDT design that were drawn from testing.

  18. Anti-malarial Drug Design by Targeting Apicoplasts: New Perspectives

    Directory of Open Access Journals (Sweden)

    Avinaba Mukherjee

    2016-03-01

    Full Text Available Objectives: Malaria has been a major global health problem in recent times with increasing mortality. Current treatment methods include parasiticidal drugs and vaccinations. However, resistance among malarial parasites to the existing drugs has emerged as a significant area of concern in anti-malarial drug design. Researchers are now desperately looking for new targets to develop anti-malarials drug which is more target specific. Malarial parasites harbor a plastid-like organelle known as the ‘apicoplast’, which is thought to provide an exciting new outlook for the development of drugs to be used against the parasite. This review elaborates on the current state of development of novel compounds targeted againstemerging malaria parasites. Methods: The apicoplast, originates by an endosymbiotic process, contains a range of metabolic pathways and housekeeping processes that differ from the host body and thereby presents ideal strategies for anti-malarial drug therapy. Drugs are designed by targeting the unique mechanism of the apicoplasts genetic machinery. Several anabolic and catabolic processes, like fatty acid, isopenetyl diphosphate and heme synthess in this organelle, have also been targeted by drugs. Results: Apicoplasts offer exciting opportunities for the development of malarial treatment specific drugs have been found to act by disrupting this organelle’s function, which wouldimpede the survival of the parasite. Conclusion: Recent advanced drugs, their modes of action, and their advantages in the treatment of malaria by using apicoplasts as a target are discussed in this review which thought to be very useful in desigining anti-malarial drugs. Targetting the genetic machinery of apicoplast shows a great advantange regarding anti-malarial drug design. Critical knowledge of these new drugs would give a healthier understanding for deciphering the mechanism of action of anti-malarial drugs when targeting apicoplasts to overcome drug

  19. EU-APR Design in compliance with EUR Grid Requirement

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Dong-Hwan; Lee, Keun-Sung [KHNP CRI, Daejeon (Korea, Republic of)

    2016-10-15

    European Utility Requirements (EUR) provides technical requirements for the generation III nuclear power plant in the European countries. EUR grid requirements present the plant requirements to satisfy the needs of the grid network. The grid requirements are the precondition for the operation of a generating plant on the network. This paper describes EU-APR design which has taken account of EUR grid requirements. In this paper, EU-APR designs according to the EUR grid requirements were described. EU-APR was designed in compliance with the voltage and frequency operation field and also designed to have the capability of load following such as primary control, secondary control, and daily load following. Consequently, the EU-APR design according to the EUR grid requirements is expected to get competitiveness and enhance the license feasibility in the European nuclear market.

  20. Designing to target cost: one approach to design/construction integration

    DEFF Research Database (Denmark)

    Jørgensen, Bo

    2005-01-01

    One approach to a more integrated construction delivery process is the concept of ‘designing to target cost’ of which the first examples of application within a lean construction framework have recently been seen. This paper introduces the main principles of the design to target cost method...... and discusses the applicability of this approach to construction. The low degree of organizational and technical continuity from one construction project to the next limits the applicability of the design for target cost approach when compared to its origin in product development of mass manufactured artefacts....... It can be argued that design to target cost may also provide a frame for developing the supply chain towards better coordination and collaboration. Thus methods of design to target cost may serve to facilitate the development of a more integrated supply chain....

  1. 7 CFR 801.12 - Design requirements incorporated by reference.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false Design requirements incorporated by reference. 801.12 Section 801.12 Agriculture Regulations of the Department of Agriculture (Continued) GRAIN INSPECTION... OFFICIAL PERFORMANCE REQUIREMENTS FOR GRAIN INSPECTION EQUIPMENT § 801.12 Design requirements incorporated...

  2. Design requirement for electrical system of an advanced research reactor

    International Nuclear Information System (INIS)

    Jung, Hoan Sung; Kim, H. K.; Kim, Y. K.; Wu, J. S.; Ryu, J. S.

    2004-12-01

    An advanced research reactor is being designed since 2002 and the conceptual design has been completed this year for the several types of core. Also the fuel was designed for the potential cores. But the process system, the I and C system, and the electrical system design are under pre-conceptual stage. The conceptual design for those systems will be developed in the next year. Design requirements for the electrical system set up to develop conceptual design. The same goals as reactor design - enhance safety, reliability, economy, were applied for the development of the requirements. Also the experience of HANARO design and operation was based on. The design requirements for the power distribution, standby power supply, and raceway system will be used for the conceptual design of electrical system

  3. Design requirement for electrical system of an advanced research reactor

    Energy Technology Data Exchange (ETDEWEB)

    Jung, Hoan Sung; Kim, H. K.; Kim, Y. K.; Wu, J. S.; Ryu, J. S

    2004-12-01

    An advanced research reactor is being designed since 2002 and the conceptual design has been completed this year for the several types of core. Also the fuel was designed for the potential cores. But the process system, the I and C system, and the electrical system design are under pre-conceptual stage. The conceptual design for those systems will be developed in the next year. Design requirements for the electrical system set up to develop conceptual design. The same goals as reactor design - enhance safety, reliability, economy, were applied for the development of the requirements. Also the experience of HANARO design and operation was based on. The design requirements for the power distribution, standby power supply, and raceway system will be used for the conceptual design of electrical system.

  4. 7 CFR 801.11 - Related design requirements.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false Related design requirements. 801.11 Section 801.11... FOR GRAIN INSPECTION EQUIPMENT § 801.11 Related design requirements. (a) Suitability. The design... tolerances prescribed in §§ 801.3 through 801.10, be capable of repeating its results when the equipment is...

  5. Two psig service requires proper design concepts

    International Nuclear Information System (INIS)

    Veraa, G.S.

    1991-01-01

    This paper reports that Washington Gas (WG) established a 2 psig house line delivery system in the late 1980s to compete with electric utilities and recapture its share of the natural gas market. A trend away from installing natural gas in new housing required WG to improve construction materials, develop cost-cutting techniques and provide new regulators and metering to convince builders of the advantages of natural gas systems. WG serves approximately 650,000 customers in Washington D.C. and the surrounding counties in Virginia and Maryland. Over the last few years, WG has been adding about 20,000 new customers per year. In the 1970s when natural gas was in short supply, a moratorium was imposed on new customers. When the moratorium was finally lifted in the late 1970s, the electric utilities had captured most of the new housing energy market. Innovative marketing efforts were needed to win market share and compete with the electric utilities, but several factors combined to inhibit new gas sales. First, builders had grown accustomed to specifying electric heat pumps for house heating and had a certain amount of resistance to change. Although market research indicated that new home buyers preferred natural gas, many builders did not want to deal with another utility. Also, gas piping increased construction costs. Traditional gas house piping is rigid black pipe which is cut and fit on the job. The right angle turns limit where the pipe can be run, making it labor intensive to install. Safety was another important consideration. Normally, an internal relief valve provides sufficient over-pressure protection in the event of a regulator full-valve failure. The 2 psig delivery pressure required a review of what type of over-pressure protection should be provided

  6. Nuclear Data Target Accuracy Requirements For MA Burners

    International Nuclear Information System (INIS)

    Palmiotti, G.; Salvatores, M.

    2011-01-01

    A nuclear data target accuracy assessment has been carried out for two types of transmuters: a critical sodium fast reactor(SFR) and an accelerator driven system (ADMAB). Results are provided for a 7 group energy structure. Considerations about fuel cycle parameters uncertainties illustrate their dependence from the isotope final densities at end of cycle.

  7. Engineering design of the EURISOL multi-MW spallation target

    CERN Document Server

    Herrera-Martínez, A; Ashrafi-Nik, M; Samec, K; Freibergs, J; Platacis, E

    2007-01-01

    The European Isotope Separation On-Line Radioactive Ion Beam project (EURISOL) is set to design the 'next-generation' European Isotope Separation On-Line (ISOL) Radioactive Ion Beam (RIB) facility. It will extend and amplify current research on nuclear physics, nuclear astrophysics and fundamental interactions beyond the year 2010. In EURISOL, four target stations are foreseen, three direct targets of approximately 100 kW of beam power and one multi-MW target assembly, all driven by a high-power particle accelerator. In this high power target station, high-intensity RIBs of neutron-rich isotopes will be obtained by inducing fission in several actinide targets surrounding a liquid metal spallation neutron source. This article summarises the work carried out within Task 2 of the EURISOL Design Study, with special attention to the coupled neutronics of the mercury proton-to-neutron converter and the fission targets. The overall performance of the facility, which will sustain fast neutron fluxes of the order of 1...

  8. ENGINEERING DESIGN OF THE EURISOL MULTI-MW SPALLATION TARGET

    CERN Document Server

    Adonai Herrera-Martinez*, Yacine Kadi, Morteza Ashrafi-Nik, Karel Samec, Janis Freibergs, Ernests Platacis

    The European Isotope Separation On-Line Radioactive Ion Beam project (EURISOL) is set to design the ‘next-generation’ European Isotope Separation On-Line (ISOL) Radioactive Ion Beam (RIB) facility. It will extend and amplify current research on nuclear physics, nuclear astrophysics and fundamental interactions beyond the year 2010. In EURISOL, four target stations are foreseen, three direct targets of approximately 100 kW of beam power and one multi-MW target assembly, all driven by a high-power particle accelerator. In this high power target station, high-intensity RIBs of neutron-rich isotopes will be obtained by inducing fission in several actinide targets surrounding a liquid metal spallation neutron source. This article summarises the work carried out within Task 2 of the EURISOL Design Study, with special attention to the coupled neutronics of the mercury proton-to-neutron converter and the fission targets. The overall performance of the facility, which will sustain fast neutron fluxes of the order ...

  9. REQUIREMENTS FOR DESIGN, EQUIPMENT AND OPERATION MODE OF TAXI VEHICLES

    Directory of Open Access Journals (Sweden)

    Norayr Oganesovich Bludyan

    2015-09-01

    Full Text Available The analysis of international experience in application of requirements for the taxi vehicles design and equipment. The approaches to improvement of cabbing have been defined by determination of requirements for taxi vehicles.

  10. Mechanical design and development of a high power target system for the SLC Positron Source

    International Nuclear Information System (INIS)

    Reuter, E.; Mansour, D.; Porter, T.; Sax, W.; Szumillo, A.

    1991-12-01

    In order to bring the SLC Positron Source luminosity up to design specifications, the previous (stationary) positron target had to be replaced with a version which could reliably dissipate the higher power levels and cyclic pulsed thermal stresses of the high intensity 33GeV electron beam. In addition to this basic requirement, the new target system had to meet SLAC's specifications for Ultra High Vacuum, be remotely controllable, ''radiation hard,'' and designed in such a way that it could be removed and replaced quickly and easily with minimum personnel exposure to radiation. It was also desirable to integrate the target and collection components into a compact, easily manufacturable, and easily maintainable module. This paper briefly summarize the mechanical design and development of the new modular target system, its associated controls and software, alignment, and the quick removal system. Operational experience gained with the new system over the first running cycle is also summarized

  11. Massively parallel de novo protein design for targeted therapeutics

    KAUST Repository

    Chevalier, Aaron; Silva, Daniel-Adriano; Rocklin, Gabriel J.; Hicks, Derrick R.; Vergara, Renan; Murapa, Patience; Bernard, Steffen M.; Zhang, Lu; Lam, Kwok-Ho; Yao, Guorui; Bahl, Christopher D.; Miyashita, Shin-Ichiro; Goreshnik, Inna; Fuller, James T.; Koday, Merika T.; Jenkins, Cody M.; Colvin, Tom; Carter, Lauren; Bohn, Alan; Bryan, Cassie M.; Ferná ndez-Velasco, D. Alejandro; Stewart, Lance; Dong, Min; Huang, Xuhui; Jin, Rongsheng; Wilson, Ian A.; Fuller, Deborah H.; Baker, David

    2017-01-01

    De novo protein design holds promise for creating small stable proteins with shapes customized to bind therapeutic targets. We describe a massively parallel approach for designing, manufacturing and screening mini-protein binders, integrating large-scale computational design, oligonucleotide synthesis, yeast display screening and next-generation sequencing. We designed and tested 22,660 mini-proteins of 37-43 residues that target influenza haemagglutinin and botulinum neurotoxin B, along with 6,286 control sequences to probe contributions to folding and binding, and identified 2,618 high-affinity binders. Comparison of the binding and non-binding design sets, which are two orders of magnitude larger than any previously investigated, enabled the evaluation and improvement of the computational model. Biophysical characterization of a subset of the binder designs showed that they are extremely stable and, unlike antibodies, do not lose activity after exposure to high temperatures. The designs elicit little or no immune response and provide potent prophylactic and therapeutic protection against influenza, even after extensive repeated dosing.

  12. Massively parallel de novo protein design for targeted therapeutics

    KAUST Repository

    Chevalier, Aaron

    2017-09-26

    De novo protein design holds promise for creating small stable proteins with shapes customized to bind therapeutic targets. We describe a massively parallel approach for designing, manufacturing and screening mini-protein binders, integrating large-scale computational design, oligonucleotide synthesis, yeast display screening and next-generation sequencing. We designed and tested 22,660 mini-proteins of 37-43 residues that target influenza haemagglutinin and botulinum neurotoxin B, along with 6,286 control sequences to probe contributions to folding and binding, and identified 2,618 high-affinity binders. Comparison of the binding and non-binding design sets, which are two orders of magnitude larger than any previously investigated, enabled the evaluation and improvement of the computational model. Biophysical characterization of a subset of the binder designs showed that they are extremely stable and, unlike antibodies, do not lose activity after exposure to high temperatures. The designs elicit little or no immune response and provide potent prophylactic and therapeutic protection against influenza, even after extensive repeated dosing.

  13. Massively parallel de novo protein design for targeted therapeutics

    Science.gov (United States)

    Chevalier, Aaron; Silva, Daniel-Adriano; Rocklin, Gabriel J.; Hicks, Derrick R.; Vergara, Renan; Murapa, Patience; Bernard, Steffen M.; Zhang, Lu; Lam, Kwok-Ho; Yao, Guorui; Bahl, Christopher D.; Miyashita, Shin-Ichiro; Goreshnik, Inna; Fuller, James T.; Koday, Merika T.; Jenkins, Cody M.; Colvin, Tom; Carter, Lauren; Bohn, Alan; Bryan, Cassie M.; Fernández-Velasco, D. Alejandro; Stewart, Lance; Dong, Min; Huang, Xuhui; Jin, Rongsheng; Wilson, Ian A.; Fuller, Deborah H.; Baker, David

    2018-01-01

    De novo protein design holds promise for creating small stable proteins with shapes customized to bind therapeutic targets. We describe a massively parallel approach for designing, manufacturing and screening mini-protein binders, integrating large-scale computational design, oligonucleotide synthesis, yeast display screening and next-generation sequencing. We designed and tested 22,660 mini-proteins of 37–43 residues that target influenza haemagglutinin and botulinum neurotoxin B, along with 6,286 control sequences to probe contributions to folding and binding, and identified 2,618 high-affinity binders. Comparison of the binding and non-binding design sets, which are two orders of magnitude larger than any previously investigated, enabled the evaluation and improvement of the computational model. Biophysical characterization of a subset of the binder designs showed that they are extremely stable and, unlike antibodies, do not lose activity after exposure to high temperatures. The designs elicit little or no immune response and provide potent prophylactic and therapeutic protection against influenza, even after extensive repeated dosing. PMID:28953867

  14. Design considerations for foil windows for PET radioisotope targets

    International Nuclear Information System (INIS)

    Hughey, B.J.; Shefer, R.E.; Klinkowstein, R.E.; Welch, M.J.

    1992-01-01

    This paper describes the results of a study performed at SRL to develop analytical and computational techniques for optimizing the design of conduction-cooled foil windows for PET targets. Single foil conduction cooled windows have been found to be good target entrance windows for both low energy accelerators and medium energy cyclotrons. Detailed thermal analysis has given an approximate analytical expression for the maximum temperature reached in a foil window under conditions of realistic ion beam bombardment. The effects of 'hot spots' in the beam density profile were investigated. It was shown that a factor of two safety margin in window design should be adequate to compensate for any possible beam hot spots. In addition, the reduction of foil stress by slack mounting was verified by experiments. The properties of conventional and novel foil materials were investigated for use in conduction cooled windows. Novel foil materials include two-component Al/Ti and Al/Havar foil. Results on the testing of candidate foil materials for thermal conductivity and mechanical strength at elevated temperature were presented. Two optimum foil window geometries were analyzed: a high aspect ratio window and a multiply slotted window. The multiply slotted window combines the advantages of a high aspect ratio foil window with a circular beam strike and is a promising window design for both TCA and cyclotron targets. A multiply slotted window for a N 2 gas target for 15 O production was designed using the methodologies discussed above. This prototype target was successfully tested using the TCA beam at SRL. (author) 6 figs., 3 tabs., 10 refs

  15. The IFS for WFIRST CGI: Science Requirements to Design

    Science.gov (United States)

    Groff, Tyler; Gong, Qian; Mandell, Avi M.; Zimmerman, Neil; Rizzo, Maxime; McElwain, Michael; harvey, david; Saxena, Prabal; cady, eric; mejia prada, camilo

    2018-01-01

    Direct Imaging of exoplanets using a coronagraph has become a major field of research both on the ground and in space. Key to the science of direct imaging is the spectroscopic capabilities of the instrument, our ability to extract spectra, and measure the abundance of molecular species such as Methane. To take these spectra, the WFIRST coronagraph instrument (CGI) uses an integral field spectrograph (IFS), which encodes the spectrum into a two-dimensional image on the detector. This results in more efficient detection and characterization of targets, and the spectral information is critical to achieving detection limits below the speckle floor of the imager. The CGI IFS operates in three 18% bands spanning 600nm to 970nm at a nominal spectral resolution of R50. We present the current science and engineering requirements for the IFS design, the instrument design, anticipated performance, and how the calibration is integrated into the focal plane wavefront control algorithms. We also highlight the role of the Prototype Imaging Spectrograph for Coronagraphic Exoplanet Studies (PISCES) at the JPL High Contrast Imaging Testbed to demonstrate performance and validate calibration methodologies for the flight instrument.

  16. Introduction to spallation physics and spallation-target design

    Energy Technology Data Exchange (ETDEWEB)

    Russell, G.J.; Pitcher, E.J.; Daemen, L.L. [Los Alamos National Laboratory, NM (United States)

    1995-10-01

    When coupled with the spallation process in appropriate target materials, high-power accelerators can be used to produce large numbers of neutrons, thus providing an alternate method to the use of nuclear reactors for this purpose. Spallation offers exciting new possibilities for generating intense neutron fluxes for a variety of applications, including: (a) spallation-neutron sources for materials science research; (b) accelerator-based production of tritium; (c) accelerator-based transmutation of waste; (d) accelerator-based destruction of plutonium; and (e) radioisotope production for medical and energy applications. Target design plays a key role in these applications, with neutron production/leakage being strongly dependent on the incident particle type and energy, and target material and geometry.

  17. Directives and general design requirements for a small PWR

    International Nuclear Information System (INIS)

    Arrieta, L.A.

    1992-08-01

    A proposal of directives and general requirements for the development of a small PWR conceptual design is presented. These directives address the main safety, performance and economic design aspects. The purpose is to use this work as a base for a wide discussion, involving all project participants, culminating with the definition of the final directives and general requirements. (author)

  18. General-purpose heat source development. Phase I: design requirements

    International Nuclear Information System (INIS)

    Snow, E.C.; Zocher, R.W.

    1978-09-01

    Studies have been performed to determine the necessary design requirements for a 238 PuO 2 General-Purpose Heat Source (GPHS). Systems and missions applications, as well as accident conditions, were considered. The results of these studies, along with the recommended GPHS design requirements, are given in this report

  19. Optimum nuclear design of target fuel rod for Mo-99 production in HANARO

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Myung Hyun [Kyung Hee University, Seoul (Korea)

    1998-04-01

    Nuclear target design for Mo-99 production in HANARO was performed, KAERI proposed target design was analyzed and its feasibility was shown. Three commercial target designs of Cintichem, ANL and KAERI were tested for the HANARO irradiation an d they all satisfied with design specification. A parametric study was done for target design options and Mo-99 yields ratio and surface heat flux were compared. Tested parameters were target fuel thickness, irradiation location, target axial length, packing density of powder fuel, size of target radius, target geometry, fuel enrichment, fuel composition, and cladding material. Optimized target fuel was designed for both LEU and HEU options. (author). 17 refs., 33 figs., 42 tabs.

  20. Safety design guides for seismic requirements for CANDU 9

    International Nuclear Information System (INIS)

    Lee, Duk Su; Chang, Woo Hyun; Lee, Nam Young; A. C. D. Wright

    1996-03-01

    This safety design guide for seismic requirements for CANDU 9 describes the seismic design philosophy, defines the applicable earthquakes and identifies the structures and systems requiring seismic qualification to ensure that the essential safety function can be adequately satisfied following earthquake. The detailed requirements for structures, systems and components which must be seismically qualified are specified in the Appendix. The change status of the regulatory requirements, code and standards should be traced and this safety design guide shall be updated accordingly. 1 fig., (Author) .new

  1. Rare isotope accelerator—conceptual design of target areas

    Science.gov (United States)

    Bollen, Georg; Baek, Inseok; Blideanu, Valentin; Lawton, Don; Mantica, Paul F.; Morrissey, David J.; Ronningen, Reginald M.; Sherrill, Bradley S.; Zeller, Albert; Beene, James R.; Burgess, Tom; Carter, Kenneth; Carrol, Adam; Conner, David; Gabriel, Tony; Mansur, Louis; Remec, Igor; Rennich, Mark; Stracener, Dan; Wendel, Mark; Ahle, Larry; Boles, Jason; Reyes, Susana; Stein, Werner; Heilbronn, Lawrence

    2006-06-01

    The planned rare isotope accelerator facility RIA in the US would become the most powerful radioactive beam facility in the world. RIA's driver accelerator will be a device capable of providing beams from protons to uranium at energies of at least 400 MeV per nucleon, with beam power up to 400 kW. Radioactive beam production relies on both the in-flight separation of fast beam fragments and on the ISOL technique. In both cases the high beam power poses major challenges for target technology and handling and on the design of the beam production areas. This paper will give a brief overview of RIA and discuss aspects of ongoing conceptual design work for the RIA target areas.

  2. Rare Isotope Accelerator - Conceptual Design of Target Areas

    Energy Technology Data Exchange (ETDEWEB)

    Bollen, Georg [Michigan State University, East Lansing; Baek, Inseok [Michigan State University, East Lansing; Blideanu, Valentin [CEA, Saclay, France; Lawton, Don [Michigan State University, East Lansing; Mantica, Paul F. [Michigan State University, East Lansing; Morrissey, David J. [Michigan State University, East Lansing; Ronningen, Reginald M. [Michigan State University, East Lansing; Sherrill, Bradley S. [Michigan State University, East Lansing; Zeller, Albert [Michigan State University, East Lansing; Beene, James R [ORNL; Burgess, Tom [Oak Ridge National Laboratory (ORNL); Carter, Kenneth [Oak Ridge National Laboratory (ORNL); Carrol, Adam [Oak Ridge National Laboratory (ORNL); Conner, David [ORNL; Gabriel, Tony A [ORNL; Mansur, Louis K [ORNL; Remec, Igor [ORNL; Rennich, Mark J [ORNL; Stracener, Daniel W [ORNL; Wendel, Mark W [ORNL; Ahle, Larry [Lawrence Livermore National Laboratory (LLNL); Boles, Jason [Lawrence Livermore National Laboratory (LLNL); Reyes, Susana [Lawrence Livermore National Laboratory (LLNL); Stein, Werner [Lawrence Livermore National Laboratory (LLNL); Heilbronn, Lawrence [Lawrence Berkeley National Laboratory (LBNL)

    2006-01-01

    The planned rare isotope accelerator facility RIA in the US would become the most powerful radioactive beam facility in the world. RIA s driver accelerator will be a device capable of providing beams from protons to uranium at energies of at least 400MeV per nucleon, with beam power up to 400 kW. Radioactive beam production relies on both the in-flight separation of fast beam fragments and on the ISOL technique. In both cases the high beam power poses major challenges for target technology and handling and on the design of the beam production areas. This paper will give a brief overview of RIA and discuss aspects of ongoing conceptual design work for the RIA target areas.

  3. New designs of LMJ targets for early ignition experiments

    International Nuclear Information System (INIS)

    Clerouin, C; Bonnefille, M; Dattolo, E; Fremerye, P; Galmiche, D; Gauthier, P; Giorla, J; Laffite, S; Liberatore, S; Loiseau, P; Malinie, G; Masse, L; Poggi, F; Seytor, P

    2008-01-01

    The LMJ experimental plans include the attempt of ignition and burn of an ICF capsule with 40 laser quads, delivering up to 1.4MJ and 380TW. New targets needing reduced laser energy with only a small decrease in robustness are then designed for this purpose. A first strategy is to use scaled-down cylindrical hohlraums and capsules, taking advantage of our better understanding of the problem, set on theoretical modelling, simulations and experiments. Another strategy is to work specifically on the coupling efficiency parameter, i.e. the ratio of the energy absorbed by the capsule to the laser energy, which is with parametric instabilities a crucial drawback of indirect drive. An alternative design is proposed, made up of the nominal 60 quads capsule, named A1040, in a rugby-shaped hohlraum. Robustness evaluations of these different targets are in progress

  4. New designs of LMJ targets for early ignition experiments

    Energy Technology Data Exchange (ETDEWEB)

    Clerouin, C; Bonnefille, M; Dattolo, E; Fremerye, P; Galmiche, D; Gauthier, P; Giorla, J; Laffite, S; Liberatore, S; Loiseau, P; Malinie, G; Masse, L; Poggi, F; Seytor, P [Commissariat a l' Energie Atomique, DAM-Ile de France, BP 12 91680 Bruyeres-le-Chatel (France)], E-mail: catherine.cherfils@cea.fr

    2008-05-15

    The LMJ experimental plans include the attempt of ignition and burn of an ICF capsule with 40 laser quads, delivering up to 1.4MJ and 380TW. New targets needing reduced laser energy with only a small decrease in robustness are then designed for this purpose. A first strategy is to use scaled-down cylindrical hohlraums and capsules, taking advantage of our better understanding of the problem, set on theoretical modelling, simulations and experiments. Another strategy is to work specifically on the coupling efficiency parameter, i.e. the ratio of the energy absorbed by the capsule to the laser energy, which is with parametric instabilities a crucial drawback of indirect drive. An alternative design is proposed, made up of the nominal 60 quads capsule, named A1040, in a rugby-shaped hohlraum. Robustness evaluations of these different targets are in progress.

  5. Rare isotope accelerator - conceptual design of target areas

    International Nuclear Information System (INIS)

    Bollen, Georg; Baek, Inseok; Blideanu, Valentin; Lawton, Don; Mantica, Paul F.; Morrissey, David J.; Ronningen, Reginald M.; Sherrill, Bradley S.; Zeller, Albert; Beene, James R; Burgess, Tom; Carter, Kenneth; Carrol, Adam; Conner, David; Gabriel, Tony A; Mansur, Louis K; Remec, Igor; Rennich, Mark J; Stracener, Daniel W; Wendel, Mark W; Ahle, Larry; Boles, Jason; Reyes, Susana; Stein, Werner; Heilbronn, Lawrence

    2006-01-01

    The planned rare isotope accelerator facility RIA in the US would become the most powerful radioactive beam facility in the world. RIA's driver accelerator will be a device capable of providing beams from protons to uranium at energies of at least 400MeV per nucleon, with beam power up to 400 kW. Radioactive beam production relies on both the in-flight separation of fast beam fragments and on the ISOL technique. In both cases the high beam power poses major challenges for target technology and handling and on the design of the beam production areas. This paper will give a brief overview of RIA and discuss aspects of ongoing conceptual design work for the RIA target areas

  6. Rare isotope accelerator-conceptual design of target areas

    Energy Technology Data Exchange (ETDEWEB)

    Bollen, Georg [National Superconducting Cyclotron Laboratory, Michigan State University, East Lansing, MI 48824 (United States)]. E-mail: bollen@nscl.msu.edu; Baek, Inseok; Blideanu, Valentin; Lawton, Don; Mantica, Paul F.; Morrissey, David J.; Ronningen, Reginald M.; Sherrill, Bradley S.; Zeller, Albert [National Superconducting Cyclotron Laboratory, Michigan State University, East Lansing, MI 48824 (United States); Beene, James R.; Burgess, Tom; Carter, Kenneth; Carrol, Adam; Conner, David; Gabriel, Tony; Mansur, Louis; Remec, Igor; Rennich, Mark; Stracener, Dan; Wendel, Mark [Oak Ridge National Laboratory, Oak Ridge, TN 37830 (United States); Ahle, Larry; Boles, Jason; Reyes, Susana; Stein, Werner [Lawrence Livermore Laboratory, Livermore, CA 94550 (United States); Heilbronn, Lawrence [Lawrence Berkeley National Laboratory, Berkeley, CA 94720 (United States)

    2006-06-23

    The planned rare isotope accelerator facility RIA in the US would become the most powerful radioactive beam facility in the world. RIA's driver accelerator will be a device capable of providing beams from protons to uranium at energies of at least 400 MeV per nucleon, with beam power up to 400 kW. Radioactive beam production relies on both the in-flight separation of fast beam fragments and on the ISOL technique. In both cases the high beam power poses major challenges for target technology and handling and on the design of the beam production areas. This paper will give a brief overview of RIA and discuss aspects of ongoing conceptual design work for the RIA target areas.

  7. Spallation neutron source target design for radioactive waste transmutation

    International Nuclear Information System (INIS)

    Beard, C.A.

    1992-01-01

    The disposal of high-level radioactive waste has long been one of the most serious problems facing the nuclear industry. Transmutation of this waste through particle bombardment has been suggested numerous times as a possible method of enhancing the waste management process. Due to advances in accelerator technology, the feasibility of an accelerator based transmutation system has increased enough to allow serious investigation of this process. Therefore, in pursuit of this goal, an accelerator target was designed for use in an accelerator based transmutation system. The target design consists of an array of tantalum rods, cooled by liquid sodium, which are arranged in a cylindrical configuration 40 cm in diameter and 125 cm in height. Tantalum was chosen as the target material over tungsten, lead, bismuth, and a lead-bismuth alloy (55 w/o bismuth) due to a large neutron yield, low activation, low chemical toxicity, and the fact that it does not produce significant amounts of long-lived isotopes through spallation or activation. The target yields a neutron source of 29.7 neutrons/proton when exposed to a 1600 MeV proton beam, and is suitable for use with both thermal or fast spectrum transmutation systems

  8. Design and implementation of typical target image database system

    International Nuclear Information System (INIS)

    Qin Kai; Zhao Yingjun

    2010-01-01

    It is necessary to provide essential background data and thematic data timely in image processing and application. In fact, application is an integrating and analyzing procedure with different kinds of data. In this paper, the authors describe an image database system which classifies, stores, manages and analyzes database of different types, such as image database, vector database, spatial database, spatial target characteristics database, its design and structure. (authors)

  9. Design requirement on KALIMER blanket fuel assembly duct

    International Nuclear Information System (INIS)

    Hwang, Woan; Kang, H. Y.; Nam, C.; Kim, J. O.

    1998-03-01

    This document describes design requirements which are needed for designing the blanket fuel assembly duct of the KALIMER as design guidance. The blanket fuel assembly duct of the KALIMER consists of fuel rods, mounting rail, nosepiece, duct with pad, handling socket with pad. Blanket fuel rod consists of top end plug, bottom end plug with solid ferritic-martensitic steel rod and key way blanket fuel slug, cladding, and wire wrap. In the assembly, the rods are in a triangular pitch array, and the rod bundle is attached to the nosepiece with mounting rails. The bottom end of the assembly duct is formed by a long nosepiece which provides the lower restraint function and the paths for coolant inlet. This report contains functional requirements, performance and operational requirements, interfacing systems requirements, core restraint and interface requirements, design limits and strength requirements, system configuration and essential feature requirements, seismic requirements, structural requirements, environmental requirements, reliability and safety requirements, standard and codes, QA programs, and other requirements. (author). 20 refs., 4 figs

  10. Assessment of Performance-based Requirements for Structural Design

    DEFF Research Database (Denmark)

    Hertz, Kristian Dahl

    2005-01-01

    and for a detailed assessment of the requirements. The design requirements to be used for a factory producing elements for industrial housing for unknown costumers are discussed, and a fully developed fire is recommended as a common requirement for domestic houses, hotels, offices, schools and hospitals. In addition...

  11. Project W-441 cold vacuum drying facility design requirements document

    International Nuclear Information System (INIS)

    O'Neill, C.T.

    1997-01-01

    This document has been prepared and is being released for Project W-441 to record the design basis for the design of the Cold Vacuum Drying Facility. This document sets forth the physical design criteria, Codes and Standards, and functional requirements that were used in the design of the Cold Vacuum Drying Facility. This document contains section 3, 4, 6, and 9 of the Cold Vacuum Drying Facility Design Requirements Document. The remaining sections will be issued at a later date. The purpose of the Facility is to dry, weld, and inspect the Multi-Canister Overpacks before transport to dry storage

  12. Visual Pollution in the Context of Conflicting Design Requirements

    Directory of Open Access Journals (Sweden)

    Sumartono Sumartono

    2009-07-01

    Full Text Available All designs (graphic, product, and interior designs are directed to consider certain requirements which are followed by logical thinking to fulfill a design process. Once the requirements of each design have been well-considered and the logical design process has been fulfilled, the design is complete. Ideally, all designs are not supposed to be in conflict with each other because each one is based on a logical design process. In reality, however, the mutual existence of these designs has produced conflicting requirements and thereby conflicting logics. This conflict can be seen in visual pollution. This paper will examine the impact of visual pollution caused by billboards, street signs, posters, houses/buildings, automobiles, shopfront graphic designs, packaging designs, graffiti, etc. in the context of conflicting logics/requirements. Today, opposition grows everywhere against all visually polluting designs and outdoor advertising is the most prominent one. Some people think that it should be banned from the city. Some others, however, think that if advertisements are removed from the city, it will become a bland concrete jungle. Every city in Indonesia needs a clean-city law to control illegal advertisements and signs. It is possible to make legal yet attractive advertisements that will give positive contribution to “visual democracy” in Indonesia.

  13. Benchmarking CRISPR on-target sgRNA design.

    Science.gov (United States)

    Yan, Jifang; Chuai, Guohui; Zhou, Chi; Zhu, Chenyu; Yang, Jing; Zhang, Chao; Gu, Feng; Xu, Han; Wei, Jia; Liu, Qi

    2017-02-15

    CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats)-based gene editing has been widely implemented in various cell types and organisms. A major challenge in the effective application of the CRISPR system is the need to design highly efficient single-guide RNA (sgRNA) with minimal off-target cleavage. Several tools are available for sgRNA design, while limited tools were compared. In our opinion, benchmarking the performance of the available tools and indicating their applicable scenarios are important issues. Moreover, whether the reported sgRNA design rules are reproducible across different sgRNA libraries, cell types and organisms remains unclear. In our study, a systematic and unbiased benchmark of the sgRNA predicting efficacy was performed on nine representative on-target design tools, based on six benchmark data sets covering five different cell types. The benchmark study presented here provides novel quantitative insights into the available CRISPR tools. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  14. The design of a lead-bismuth target system with a dual injection tube

    International Nuclear Information System (INIS)

    Cho, C.H.; Kim, Y.; Song, T.Y.; Park, W.S.

    2005-01-01

    A spallation target system is a key component to be developed for an accelerator driven system (ADS). It is known that a 15 ∼ 25 MW spallation target is required for a practical 1000 MWth ADS. The design of a 20 MW spallation target is very challenging because more than 60% of the beam power is deposited as heat in a small volume of the target system. In the present work, a numerical design study was performed to obtain the optimal design parameters for a 20 MW spallation target for a 1000 MW ADS. A dual injection tube was proposed for the reduction of the LBE flow rate at the target channel. The results of the present study show that a 30 cm wide proton beam with a uniform beam distribution should be adopted for the spallation target of a 20 MW power. When the dual LBE injection tube is employed, the LBE flow rate could be reduced by a factor of 4 without reducing the maximum allowable beam current. (authors)

  15. Customer Focused Product Design Using Integrated Model of Target Costing, Quality Function Deployment and Value Engineering

    Directory of Open Access Journals (Sweden)

    Hossein Rezaei Dolatabadi

    2013-01-01

    Full Text Available Target costing by integrating customer requirements, technical attributes and cost information into the product design phase and eliminating the non-value added functions, plays a vital role in different phases of the product life cycle. Quality Function Deployment (QFD and Value Engineering (VE are two techniques which can be used for applying target costing, successfully. The purpose of this paper is to propose an integrated model of target costing, QFD and VE to explore the role of target costing in managing product costs while promoting quality specifications meeting customers’ needs. F indings indicate that the integration of target costing, QFD and VE is an essential technique in managing the costs of production process. Findings also imply that integration of the three techniques provides a competitive cost advantage to companies.

  16. Update of bridge design standards in Alabama for AASHTO LRFD seismic design requirements.

    Science.gov (United States)

    2013-11-01

    The Alabama Department of Transportation (ALDOT) has been required to update their bridge design to the LRFD Bridge Design Specifications. This transition has resulted in changes to the seismic design standards of bridges in the state. Multiple bridg...

  17. Preliminary design implications of SSC fixed-target operation

    International Nuclear Information System (INIS)

    Zisman, M.S.

    1984-06-01

    This paper covers some of the accelerator physics issues relevant to a possible fixed-target operating mode for the Superconducting Super Collider (SSC). In the brief time available, no attempt has been made to design this capability into the SSC. Rather, I have tried to evaluate what the performance of such a machine might be, and to indicate the hardware implications and extraction considerations that would be part of an actual design study. Where appropriate, parameters and properties of the present LBL design for the SSC have been used; these should be taken as being representative of the general class of small-aperture, high-field colliders being considered by the accelerator physics community. Thus, the numerical examples given here must ultimately be reexamined in light of the actual parameters of the particular accelerator being considered

  18. Analysis of the thermomechanical behavior of the IFMIF bayonet target assembly under design loading scenarios

    Energy Technology Data Exchange (ETDEWEB)

    Bernardi, D., E-mail: davide.bernardi@enea.it [ENEA Brasimone, Camugnano, BO (Italy); Arena, P.; Bongiovì, G.; Di Maio, P.A. [Dipartimento di Energia, Ingegneria dell’Informazione e Modelli Matematici, Università di Palermo, Viale delle Scienze, Palermo (Italy); Frisoni, M. [ENEA Bologna, Via Martiri di Monte Sole 4, Bologna (Italy); Miccichè, G.; Serra, M. [ENEA Brasimone, Camugnano, BO (Italy)

    2015-10-15

    In the framework of the IFMIF Engineering Validation and Engineering Design Activities (IFMIF/EVEDA) phase, ENEA is responsible for the design of the European concept of the IFMIF lithium target system which foresees the possibility to periodically replace only the most irradiated and thus critical component (i.e., the backplate) while continuing to operate the rest of the target for a longer period (the so-called bayonet backplate concept). In this work, the results of the steady state thermomechanical analysis of the IFMIF bayonet target assembly under two different design loading scenarios (a “hot” scenario and a “cold” scenario) are briefly reported highlighting the relevant indications obtained with respect to the fulfillment of the design requirements. In particular, the analyses have shown that in the hot scenario the temperatures reached in the target assembly are within the material acceptable limits while in the cold scenario transition below the ductile to brittle transition temperature (DBTT) cannot be excluded. Moreover, results indicate that the contact between backplate and high flux test module is avoided and that the overall structural integrity of the system is assured in both scenarios. However, stress linearization analysis reveals that ITER Structural Design Criteria for In-vessel Components (SDC-IC) design rules are not always met along the selected paths at backplate middle plane section in the hot scenario, thus suggesting the need of a revision of the backplate design or a change of the operating conditions.

  19. Advances in target design and fabrication for experiments on NIF

    Directory of Open Access Journals (Sweden)

    Obrey K.

    2013-11-01

    Full Text Available The ability to build target platforms for National Ignition Facility (NIF is a key feature in LANL's (Los Alamos National Laboratory Target Fabrication Program. We recently built and manufactured the first LANL targets to be fielded on NIF in March 2011. Experiments on NIF require precision component manufacturing and accurate knowledge of the materials used in the targets. The characterization of foams and aerogels, the Be ignition capsule, and machining unique components are of main material focus. One important characterization metric the physics' have determined is that the knowledge of density gradients in foams is important. We are making strides in not only locating these density gradients in aerogels and foams as a result of how they are manufactured and machined but also quantifying the density within the foam using 3D confocal micro x-ray fluorescence (μXRF imaging and 3D x-ray computed tomography (CT imaging. In addition, collaborative efforts between General Atomics (GA and LANL in the characterization of the NIF Ignition beryllium capsule have shown that the copper in the capsule migrates radially from the capsule center.

  20. Target designs for energetics experiments on the National Ignition Facility

    International Nuclear Information System (INIS)

    Meezan, N B; Glenzer, S H; Suter, L J

    2008-01-01

    The goal of the first hohlraum energetics experiments on the National Ignition Facility (NIF) [G. H. Miller et al, Optical Eng. 43, 2841 (2004)] is to select the hohlraum design for the first ignition experiments. Sub-scale hohlraums heated by 96 of the 192 laser beams on the NIF are used to emulate the laser-plasma interaction behavior of ignition hohlraums. These 'plasma emulator' targets are 70% scale versions of the 1.05 MJ, 300 eV ignition hohlraum and have the same energy-density as the full-scale ignition designs. Radiation-hydrodynamics simulations show that the sub-scale target is a good emulator of plasma conditions inside the ignition hohlraum, reproducing density n e within 10% and temperature T e within 15% along a laser beam path. Linear backscatter gain analysis shows the backscatter risk to be comparable to that of the ignition target. A successful energetics campaign will allow the National Ignition Campaign to focus its efforts on optimizing ignition hohlraums with efficient laser coupling

  1. Modern design of far-field target motion simulators

    Science.gov (United States)

    Hauser, Robin; Swamp, Michael; Havlicsek, Howard

    2006-05-01

    Target Motion Simulators (TMS) are often used in conjunction with Flight Motion Simulators (FMS) to provide a realistic simulation of tracking and target engagement. For near-field applications, the TMS has typically been implemented with two additional gimbals around the FMS. For far-field applications, such as a radar, the TMS has traditionally been implemented with curvilinear X-Y Frames. A curvilinear frame placed at the proper distance from the FMS has the benefit of always pointing the Target back to the FMS intersection of axes. In most cases the curvilinear TMS provides good results. However, the curvilinear TMS lacks the possibility to change the distance between Target and Seeker, which is needed for operation with different radar wavelengths. Acutronic has developed a new approach using a flat frame (X-Y) TMS coupled with a gimballed payload mount that has the possibility of being used at various distances without losing the functionality of continuous pointing back to the seeker. This paper describes the electro-mechanical design and gives an overview of the Computer and Controllers used. It further addresses the problem of coordination transformation that is needed to obtain the correct pointing.

  2. Requirements' Role in Mobilizing and Enabling Design Conversation

    Science.gov (United States)

    Bergman, Mark

    Requirements play a critical role in a design conversation of systems and products. Product and system design exists at the crossroads of problems, solutions and requirements. Requirements contextualize problems and solutions, pointing the way to feasible outcomes. These are captured with models and detailed specifications. Still, stakeholders need to be able to understand one-another using shared design representations in order to mobilize bias and transform knowledge towards legitimized, desired results. Many modern modeling languages, including UML, as well as detailed, logic-based specifications are beyond the comprehension of key stakeholders. Hence, they inhibit, rather than promote design conversation. Improved design boundary objects (DBO), especially design requirements boundary objects (DRBO), need to be created and refined to improve the communications between principals. Four key features of design boundary objects that improve and promote design conversation are discussed in detail. A systems analysis and design case study is presented which demonstrates these features in action. It describes how a small team of analysts worked with key stakeholders to mobilize and guide a complex system design discussion towards an unexpected, yet desired outcome within a short time frame.

  3. IFMIF target and test cell - design and integration

    International Nuclear Information System (INIS)

    Heinzel, V.

    2007-01-01

    The International Fusion Material Irradiation Facility (IFMIF) aims at the qualification of appropriate materials for a Demonstration Fusion Power Plant (DEMO) to a fluence of up to 150 dpa (displacement per atom) at a DEMO typical neutron spectrum. It comprises two accelerators each providing a deuteron beam with 125 mA and 40 MeV. The deuterons strike a lithium target and create via stripping reactions neutrons. The neutrons are mainly forward directed into the High-Flux-Test-Module (HFTM). The Medium Flux-Test-Modules (MFTM) and the Low-Flux-Test-Modules (LFTM) are arranged in beam direction behind. In the HFTM a damage rate in steel of more than 20 dpa/fpy (displacement per atome per full power year) will be provide in a volume of 0.5 litre. The neutron spectrum is prone to produce helium and tritium in steel like in the first wall of a DEMO reactor. The Medium- Flux-Test-Modules are designed for creep fatigues in situ and tritium release test. The test modules are cooled with helium. The target is a lithium jet with a free surface towards the deuteron beams. The jet follows a concave curved so called back wall. Centrifugal forces increase the static pressure, which prevents lithium boiling at the beam tube pressure and the power release of 10 MW due to the deuteron beams. The target and Test Cell (TTC) houses the target and the test modules as well as the lithium supply tubes and a quench tank into which the lithium splashes after the target. The lithium containing components have a temperature of 250 to 350 C. Nuclear reactions mainly in beam direction contribute to heat releases in TTC components. The TTC is filled with a noble gas with almost atmospheric pressure. Natural convection transfers heat to the walls but also mitigates temperature peaks. The Forschungszentrum Karlsruhe (FZK) has developed or validated tools for: - The extended Monte Carlo Code McDeLicious for calculations of the neutron source term, dpa rates in the material specimens, activation

  4. Substantial reductions of input energy and peak power requirements in targets for heavy ion fusion

    International Nuclear Information System (INIS)

    Mark, J.W.K.; Pan, Y.L.

    1986-01-01

    Two ways of reducing the requirements of the heavy ion driver for inertial confinement fusion (ICF) target implosion are described. Compared to estimates of target gain not using these methods, the target input energy and peak power may be reduced by about a factor of two with the use of the hybrid-implosion concept. Another factor of two reduction in input energy may be obtained with the use of spin-polarized DT fuel in the ICF target

  5. Innovative product design based on comprehensive customer requirements of different cognitive levels.

    Science.gov (United States)

    Li, Xiaolong; Zhao, Wu; Zheng, Yake; Wang, Rui; Wang, Chen

    2014-01-01

    To improve customer satisfaction in innovative product design, a topology structure of customer requirements is established and an innovative product approach is proposed. The topology structure provides designers with reasonable guidance to capture the customer requirements comprehensively. With the aid of analytic hierarchy process (AHP), the importance of the customer requirements is evaluated. Quality function deployment (QFD) is used to translate customer requirements into product and process design demands and pick out the technical requirements which need urgent improvement. In this way, the product is developed in a more targeted way to satisfy the customers. the theory of innovative problems solving (TRIZ) is used to help designers to produce innovative solutions. Finally, a case study of automobile steering system is used to illustrate the application of the proposed approach.

  6. Innovative Product Design Based on Comprehensive Customer Requirements of Different Cognitive Levels

    Directory of Open Access Journals (Sweden)

    Xiaolong Li

    2014-01-01

    Full Text Available To improve customer satisfaction in innovative product design, a topology structure of customer requirements is established and an innovative product approach is proposed. The topology structure provides designers with reasonable guidance to capture the customer requirements comprehensively. With the aid of analytic hierarchy process (AHP, the importance of the customer requirements is evaluated. Quality function deployment (QFD is used to translate customer requirements into product and process design demands and pick out the technical requirements which need urgent improvement. In this way, the product is developed in a more targeted way to satisfy the customers. the theory of innovative problems solving (TRIZ is used to help designers to produce innovative solutions. Finally, a case study of automobile steering system is used to illustrate the application of the proposed approach.

  7. Supporting the design of office layout meeting ergonomics requirements.

    Science.gov (United States)

    Margaritis, Spyros; Marmaras, Nicolas

    2007-11-01

    This paper proposes a method and an information technology tool aiming to support the ergonomics layout design of individual workstations in a given space (building). The proposed method shares common ideas with previous generic methods for office layout. However, it goes a step forward and focuses on the cognitive tasks which have to be carried out by the designer or the design team trying to alleviate them. This is achieved in two ways: (i) by decomposing the layout design problem to six main stages, during which only a limited number of variables and requirements are considered and (ii) by converting the ergonomics requirements to functional design guidelines. The information technology tool (ErgoOffice 0.1) automates certain phases of the layout design process, and supports the design team either by its editing and graphical facilities or by providing adequate memory support.

  8. Operation and maintenance requirements of system design bases

    International Nuclear Information System (INIS)

    Banerjee, A.K.; Hanley, N.E.

    1989-01-01

    All system designs make assumptions about system operation testing, inspection, and maintenance. Existing industry codes and standards explicitly address design requirements of new systems, while issues related to system and plant reliability, life, design margins, effects of service conditions, operation, maintenance, etc., usually are implicit. However, system/component design documents of existing power plants often address the code requirements without considering the operation, maintenance, inspection, and testing (OMIT) requirements. The nuclear industry is expending major efforts at most nuclear power plants to reassemble and/or reconstitute system design bases. Stone ampersand Webster Engineering Corporation (SWEC) recently addressed the OMIT requirements of system/component design as an integral part of a utility's preventive maintenance program. For each component, SWEC reviewed vendor recommendations, NPRDS data/industry experience, the existing maintenance program, component service conditions, and actual plant experience. A maintenance program that considers component service conditions and plant experience ensures a connection between maintenance and design basis. Root cause analysis of failure and engineering evaluation of service condition are part of the program. System/component OMIT requirements also are compared against system design, service condition, degradation mechanism, etc., through system/component life-cycle evaluation

  9. Transforming Multidisciplinary Customer Requirements to Product Design Specifications

    Science.gov (United States)

    Ma, Xiao-Jie; Ding, Guo-Fu; Qin, Sheng-Feng; Li, Rong; Yan, Kai-Yin; Xiao, Shou-Ne; Yang, Guang-Wu

    2017-09-01

    With the increasing of complexity of complex mechatronic products, it is necessary to involve multidisciplinary design teams, thus, the traditional customer requirements modeling for a single discipline team becomes difficult to be applied in a multidisciplinary team and project since team members with various disciplinary backgrounds may have different interpretations of the customers' requirements. A new synthesized multidisciplinary customer requirements modeling method is provided for obtaining and describing the common understanding of customer requirements (CRs) and more importantly transferring them into a detailed and accurate product design specifications (PDS) to interact with different team members effectively. A case study of designing a high speed train verifies the rationality and feasibility of the proposed multidisciplinary requirement modeling method for complex mechatronic product development. This proposed research offersthe instruction to realize the customer-driven personalized customization of complex mechatronic product.

  10. Distributed Cognition in the Management of Design Requirements

    OpenAIRE

    Hansen, Sean; Lyytinen, Kalle

    2009-01-01

    In this position statement, we outline a new theoretical framework of the distribution of design requirements processes. Building upon the Theory of Distributed Cognition, we characterize contemporary requirements efforts as distributed cognitive systems in which elements of a design vision are distributed socially, structurally, and temporally. We discuss the various forms of distribution observed in real-world systems development projects and the processes by which representational states ...

  11. Flight Hardware Packaging Design for Stringent EMC Radiated Emission Requirements

    Science.gov (United States)

    Lortz, Charlene L.; Huang, Chi-Chien N.; Ravich, Joshua A.; Steiner, Carl N.

    2013-01-01

    This packaging design approach can help heritage hardware meet a flight project's stringent EMC radiated emissions requirement. The approach requires only minor modifications to a hardware's chassis and mainly concentrates on its connector interfaces. The solution is to raise the surface area where the connector is mounted by a few millimeters using a pedestal, and then wrapping with conductive tape from the cable backshell down to the surface-mounted connector. This design approach has been applied to JPL flight project subsystems. The EMC radiated emissions requirements for flight projects can vary from benign to mission critical. If the project's EMC requirements are stringent, the best approach to meet EMC requirements would be to design an EMC control program for the project early on and implement EMC design techniques starting with the circuit board layout. This is the ideal scenario for hardware that is built from scratch. Implementation of EMC radiated emissions mitigation techniques can mature as the design progresses, with minimal impact to the design cycle. The real challenge exists for hardware that is planned to be flown following a built-to-print approach, in which heritage hardware from a past project with a different set of requirements is expected to perform satisfactorily for a new project. With acceptance of heritage, the design would already be established (circuit board layout and components have already been pre-determined), and hence any radiated emissions mitigation techniques would only be applicable at the packaging level. The key is to take a heritage design with its known radiated emissions spectrum and repackage, or modify its chassis design so that it would have a better chance of meeting the new project s radiated emissions requirements.

  12. X-ray backlighting requirements for the double-shell target

    International Nuclear Information System (INIS)

    Larsen, J.T.

    1980-01-01

    We have analyzed one specific NOVA double-shell target design and have determined the x-ray energies required for probing the performance of the implosion. It is virtually impossible to study the compression of the fuel or the motion of the inner pusher. An x-ray energy of about 9 keV appears to be ideal for measuring the behavior of the outer TaCOH shell for the majority of its travel. However, it would be advantageous to have an x-ray source of about 25 keV to measure the contact between the two shells. Development of narrowband x-ray line sources are more desirable than broadband continuum sources since the intensity per keV is many times greater in the line. Intensities of the probes are determined by the self-emission levels of the target capsule. For the 9 keV line source, an intensity of upwards to 10 15 keV/keV/sh/cm 2 /sr is required with a source area of about 0.01 cm 2

  13. Trading Robustness Requirements in Mars Entry Trajectory Design

    Science.gov (United States)

    Lafleur, Jarret M.

    2009-01-01

    One of the most important metrics characterizing an atmospheric entry trajectory in preliminary design is the size of its predicted landing ellipse. Often, requirements for this ellipse are set early in design and significantly influence both the expected scientific return from a particular mission and the cost of development. Requirements typically specify a certain probability level (6-level) for the prescribed ellipse, and frequently this latter requirement is taken at 36. However, searches for the justification of 36 as a robustness requirement suggest it is an empirical rule of thumb borrowed from non-aerospace fields. This paper presents an investigation into the sensitivity of trajectory performance to varying robustness (6-level) requirements. The treatment of robustness as a distinct objective is discussed, and an analysis framework is presented involving the manipulation of design variables to effect trades between performance and robustness objectives. The scenario for which this method is illustrated is the ballistic entry of an MSL-class Mars entry vehicle. Here, the design variable is entry flight path angle, and objectives are parachute deploy altitude performance and error ellipse robustness. Resulting plots show the sensitivities between these objectives and trends in the entry flight path angles required to design to these objectives. Relevance to the trajectory designer is discussed, as are potential steps for further development and use of this type of analysis.

  14. Seismic design and evaluation criteria based on target performance goals

    International Nuclear Information System (INIS)

    Murray, R.C.; Nelson, T.A.; Kennedy, R.P.; Short, S.A.

    1994-04-01

    The Department of Energy utilizes deterministic seismic design/evaluation criteria developed to achieve probabilistic performance goals. These seismic design and evaluation criteria are intended to apply equally to the design of new facilities and to the evaluation of existing facilities. In addition, the criteria are intended to cover design and evaluation of buildings, equipment, piping, and other structures. Four separate sets of seismic design/evaluation criteria have been presented each with a different performance goal. In all these criteria, earthquake loading is selected from seismic hazard curves on a probabilistic basis but seismic response evaluation methods and acceptable behavior limits are deterministic approaches with which design engineers are familiar. For analytical evaluations, conservatism has been introduced through the use of conservative inelastic demand-capacity ratios combined with ductile detailing requirements, through the use of minimum specified material strengths and conservative code capacity equations, and through the use of a seismic scale factor. For evaluation by testing or by experience data, conservatism has been introduced through the use of an increase scale factor which is applied to the prescribed design/evaluation input motion

  15. Interaction between periodic in-service inspection requirements and design

    International Nuclear Information System (INIS)

    Prot, A.C.; Saglio, R.

    1979-03-01

    After reviewing the requirements specific of periodic In-Service Inspection related to safety problems, especially for the pressure vessels, and taking into account the experience gained with several PWR reactors, the authors show these requirements could lead to modify the primary circuit design

  16. Target selection and mass estimation for manned NEO exploration using a baseline mission design

    Science.gov (United States)

    Boden, Ralf C.; Hein, Andreas M.; Kawaguchi, Junichiro

    2015-06-01

    In recent years Near-Earth Objects (NEOs) have received an increased amount of interest as a target for human exploration. NEOs offer scientifically interesting targets, and at the same time function as a stepping stone for achieving future Mars missions. The aim of this research is to identify promising targets from the large number of known NEOs that qualify for a manned sample-return mission with a maximum duration of one year. By developing a baseline mission design and a mass estimation model, mission opportunities are evaluated based on on-orbit mass requirements, safety considerations, and the properties of the potential targets. A selection of promising NEOs is presented and the effects of mission requirements and restrictions are discussed. Regarding safety aspects, the use of free-return trajectories provides the lowest on-orbit mass, when compared to an alternative design that uses system redundancies to ensure return of the spacecraft to Earth. It is discovered that, although a number of targets are accessible within the analysed time frame, no NEO offers both easy access and high incentive for its exploration. Under the discussed aspects a first human exploration mission going beyond the vicinity of Earth will require a trade off between targets that provide easy access and those that are of scientific interest. This lack of optimal mission opportunities can be seen in the small number of only 4 NEOs that meet all requirements for a sample-return mission and remain below an on-orbit mass of 500 metric Tons (mT). All of them require a mass between 315 and 492 mT. Even less ideal, smaller asteroids that are better accessible require an on-orbit mass that exceeds the launch capability of future heavy lift vehicles (HLV) such as SLS by at least 30 mT. These mass requirements show that additional efforts are necessary to increase the number of available targets and reduce on-orbit mass requirements through advanced mission architectures. The need for on

  17. Physics design requirements for the Tokamak Physics Experiment (TPX)

    International Nuclear Information System (INIS)

    Neilson, G.H.; Goldston, R.J.; Jardin, S.C.; Reiersen, W.T.; Porkolab, M.; Ulrickson, M.

    1993-01-01

    The design of TPX is driven by physics requirements that follow from its mission. The tokamak and heating systems provide the performance and profile controls needed to study advanced steady state tokamak operating modes. The magnetic control systems provide substantial flexibility for the study of regimes with high beta and bootstrap current. The divertor is designed for high steady state power and particle exhaust

  18. Requirements for effective use of CFD in aerospace design

    Science.gov (United States)

    Raj, Pradeep

    1995-01-01

    This paper presents a perspective on the requirements that Computational Fluid Dynamics (CFD) technology must meet for its effective use in aerospace design. General observations are made on current aerospace design practices and deficiencies are noted that must be rectified for the U.S. aerospace industry to maintain its leadership position in the global marketplace. In order to rectify deficiencies, industry is transitioning to an integrated product and process development (IPPD) environment and design processes are undergoing radical changes. The role of CFD in producing data that design teams need to support flight vehicle development is briefly discussed. An overview of the current state of the art in CFD is given to provide an assessment of strengths and weaknesses of the variety of methods currently available, or under development, to produce aerodynamic data. Effectiveness requirements are examined from a customer/supplier view point with design team as customer and CFD practitioner as supplier. Partnership between the design team and CFD team is identified as an essential requirement for effective use of CFD. Rapid turnaround, reliable accuracy, and affordability are offered as three key requirements that CFD community must address if CFD is to play its rightful role in supporting the IPPD design environment needed to produce high quality yet affordable designs.

  19. Design strategies for self-assembly of discrete targets

    International Nuclear Information System (INIS)

    Madge, Jim; Miller, Mark A.

    2015-01-01

    Both biological and artificial self-assembly processes can take place by a range of different schemes, from the successive addition of identical building blocks to hierarchical sequences of intermediates, all the way to the fully addressable limit in which each component is unique. In this paper, we introduce an idealized model of cubic particles with patterned faces that allows self-assembly strategies to be compared and tested. We consider a simple octameric target, starting with the minimal requirements for successful self-assembly and comparing the benefits and limitations of more sophisticated hierarchical and addressable schemes. Simulations are performed using a hybrid dynamical Monte Carlo protocol that allows self-assembling clusters to rearrange internally while still providing Stokes-Einstein-like diffusion of aggregates of different sizes. Our simulations explicitly capture the thermodynamic, dynamic, and steric challenges typically faced by self-assembly processes, including competition between multiple partially completed structures. Self-assembly pathways are extracted from the simulation trajectories by a fully extendable scheme for identifying structural fragments, which are then assembled into history diagrams for successfully completed target structures. For the simple target, a one-component assembly scheme is most efficient and robust overall, but hierarchical and addressable strategies can have an advantage under some conditions if high yield is a priority

  20. National Ignition Facility subsystem design requirements final optics assembly subsystem SSDR 1.8.7

    International Nuclear Information System (INIS)

    Adams, C.

    1996-01-01

    This SSDR establishes the performance, design, development and test requirements for the Final Optic Assembly (FOA). The FOA (WBS 1.8.7) as part of the Target Experimental System (1.8) includes vacuum windows, frequency conversion crystals, focus lens, debris shields and supporting mechanical equipment

  1. Supplemental design requirements document solid waste operations complex

    International Nuclear Information System (INIS)

    Ocampo, V.P.; Boothe, G.F.; Broz, D.R.; Eaton, H.E.; Greager, T.M.; Huckfeldt, R.A.; Kooiker, S.L.; Lamberd, D.L.; Lang, L.L.; Myers, J.B.

    1994-11-01

    This document provides additional and supplemental information to the WHC-SD-W112-FDC-001, WHC-SD-W113-FDC-001, and WHC-SD-W100-FDC-001. It provides additional requirements for the design and summarizes Westinghouse Hanford Company key design guidance and establishes the technical baseline agreements to be used for definitive design common to the Solid Waste Operations Complex (SWOC) Facilities (Project W-112, Project W-113, and WRAP 2A)

  2. Mock Target Window OTR and IR Design and Testing

    Energy Technology Data Exchange (ETDEWEB)

    Wass, Alexander Joseph [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-09-19

    In order to fully verify temperature measurements made on the target window using infrared (IR) optical non-contact methods, actual comparative measurements are made with a real beam distribution as the heat source using Argonne National Laboratory’s (ANL) 35 MeV electron accelerator. Using Monte Carlo N-Particle (MCNP) simulations and thermal Finite Element Analysis (FEA), a cooled mock target window with thermocouple implants is designed to be used in such a test to achieve window temperatures up to 700°C. An uncoated and blackcoated mock window is designed to enhance the IR temperature measurements and verify optical transmitted radiation (OTR) imagery. This allows us to fully verify and characterize our temperature accuracy with our current IR camera method and any future method we may wish to explore using actual production conditions. This test also provides us with valuable conclusions/concerns regarding the calibration method we developed using our IR test stand at TA-53 in MPF-14.

  3. [Focus Notified Bodies. New requirements for designation and monitoring].

    Science.gov (United States)

    Poos, U; Edelhäuser, R

    2014-12-01

    For medical devices with a higher risk, Notified Bodies assess whether the manufacturers and their products fulfill the requirements laid down in the European directives on medical devices. Notified Bodies are designated through a designation procedure by the designating authority, in Germany by ZLG. The requirements for the designation arise from the respective annexes of the directives on medical devices. Since these are only minimal criteria, different documents have been compiled on a European and national level to concretize these minimal criteria regarding the organization, quality management system, resources, and certification procedure. The rules of the ZLG are thereby the essential documents for designation in Germany. Moreover, according to Implementing Regulation (EU) no. 912/2013, the European commission and the other European designating authorities also have to be involved in the designation process. The aim of continuous monitoring of the Notified Bodies with assessments on the bodies' premises as well as with observed audits is to ensure the permanent fulfillment of the requirements. If nonconformities are found in a body's quality management system or in its implementation of the conformity assessment procedures, the body is obliged to provide ZLG with a corrective actions plan. In the case that the nonconformities are not resolved in time or critical nonconformities are found, ZLG may take actions, e.g., restrict the scope of designation, suspend, or - as last resort - withdraw the designation.

  4. Research requirements for improved design of reinforced concrete containment structures

    International Nuclear Information System (INIS)

    Banerjee, A.K.; Holley, M.J. Jr.

    1978-01-01

    Reinforced concrete is a competitive material for the construction of nuclear power plant containment structures. However, the designer is constrained by limited data on the behavior of certain construction details which require him to use what may be excessive rebar quantities and lead to difficult and costly construction. This paper discusses several design situations where research is recommended to increase the designer's options, to facilitate construction, and to extend the applicability of reinforced concrete to such changing containment requirements as may be imposed by an evolving nuclear technology. (Auth.)

  5. Target design for materials processing very far from equilibrium

    Science.gov (United States)

    Barnard, John J.; Schenkel, Thomas

    2016-10-01

    Local heating and electronic excitations can trigger phase transitions or novel material states that can be stabilized by rapid quenching. An example on the few nanometer scale are phase transitions induced by the passage of swift heavy ions in solids where nitrogen-vacancy color centers form locally in diamonds when ions heat the diamond matrix to warm dense matter conditions at 0.5 eV. We optimize mask geometries for target materials such as silicon and diamond to induce phase transitions by intense ion pulses (e. g. from NDCX-II or from laser-plasma acceleration). The goal is to rapidly heat a solid target volumetrically and to trigger a phase transition or local lattice reconstruction followed by rapid cooling. The stabilized phase can then be studied ex situ. We performed HYDRA simulations that calculate peak temperatures for a series of excitation conditions and cooling rates of crystal targets with micro-structured masks. A simple analytical model, that includes ion heating and radial, diffusive cooling, was developed that agrees closely with the HYDRA simulations. The model gives scaling laws that can guide the design of targets over a wide range of parameters including those for NDCX-II and the proposed BELLA-i. This work was performed under the auspices of the U.S. DOE under contracts DE-AC52-07NA27344 (LLNL), DE-AC02-05CH11231 (LBNL) and was supported by the US DOE Office of Science, Fusion Energy Sciences. LLNL-ABS-697271.

  6. Towards Requirements in Systems Engineering for Aerospace IVHM Design

    Science.gov (United States)

    Saxena, Abhinav; Roychoudhury, Indranil; Lin, Wei; Goebel, Kai

    2013-01-01

    Health management (HM) technologies have been employed for safety critical system for decades, but a coherent systematic process to integrate HM into the system design is not yet clear. Consequently, in most cases, health management resorts to be an after-thought or 'band-aid' solution. Moreover, limited guidance exists for carrying out systems engineering (SE) on the subject of writing requirements for designs with integrated vehicle health management (IVHM). It is well accepted that requirements are key to developing a successful IVHM system right from the concept stage to development, verification, utilization, and support. However, writing requirements for systems with IVHM capability have unique challenges that require the designers to look beyond their own domains and consider the constraints and specifications of other interlinked systems. In this paper we look at various stages in the SE process and identify activities specific to IVHM design and development. More importantly, several relevant questions are posed that system engineers must address at various design and development stages. Addressing these questions should provide some guidance to systems engineers towards writing IVHM related requirements to ensure that appropriate IVHM functions are built into the system design.

  7. Design requirements for the supercritical water oxidation test bed

    International Nuclear Information System (INIS)

    Svoboda, J.M.; Valentich, D.J.

    1994-05-01

    This report describes the design requirements for the supercritical water oxidation (SCWO) test bed that will be located at the Idaho National Engineering Laboratory (INEL). The test bed will process a maximum of 50 gph of waste plus the required volume of cooling water. The test bed will evaluate the performance of a number of SCWO reactor designs. The goal of the project is to select a reactor that can be scaled up for use in a full-size waste treatment facility to process US Department of Energy mixed wastes. EG ampersand G Idaho, Inc. will design and construct the SCWO test bed at the Water Reactor Research Test Facility (WRRTF), located in the northern region of the INEL. Private industry partners will develop and provide SCWO reactors to interface with the test bed. A number of reactor designs will be tested, including a transpiring wall, tube, and vessel-type reactor. The initial SCWO reactor evaluated will be a transpiring wall design. This design requirements report identifies parameters needed to proceed with preliminary and final design work for the SCWO test bed. A flow sheet and Process and Instrumentation Diagrams define the overall process and conditions of service and delineate equipment, piping, and instrumentation sizes and configuration Codes and standards that govern the safe engineering and design of systems and guidance that locates and interfaces test bed hardware are provided. Detailed technical requirements are addressed for design of piping, valves, instrumentation and control, vessels, tanks, pumps, electrical systems, and structural steel. The approach for conducting the preliminary and final designs and environmental and quality issues influencing the design are provided

  8. Design of a deuterium and tritium-ablator shock ignition target for the National Ignition Facility

    International Nuclear Information System (INIS)

    Terry, Matthew R.; Perkins, L. John; Sepke, Scott M.

    2012-01-01

    Shock ignition presents a viable path to ignition and high gain on the National Ignition Facility (NIF). In this paper, we describe the development of the 1D design of 0.5 MJ class, all-deuterium and tritium (fuel and ablator) shock ignition target that should be reasonably robust to Rayleigh-Taylor fluid instabilities, mistiming, and hot electron preheat. The target assumes “day one” NIF hardware and produces a yield of 31 MJ with reasonable allowances for laser backscatter, absorption efficiency, and polar drive power variation. The energetics of polar drive laser absorption require a beam configuration with half of the NIF quads dedicated to launching the ignitor shock, while the remaining quads drive the target compression. Hydrodynamic scaling of the target suggests that gains of 75 and yields 70 MJ may be possible.

  9. The effect of regulatory requirements on the control and instrumentation system designer

    International Nuclear Information System (INIS)

    Golder, J.A.

    1978-01-01

    The difficulties encountered by the designer of control and protection systems for nuclear plant in attempting to satisfy the large number of imprecise regulations and recommendations which exist are described. The absence of fundamental quantitative safety requirements of international acceptability is deplored and the adoption of a major incident criteria expressed in quantitative terms as the basis for the derivation of target design criteria for protection systems and plant components is suggested. (author)

  10. Beams configuration design in target area with successive quadratic programming method

    International Nuclear Information System (INIS)

    Shi Zhiquan; Tan Jichun; Wei Xiaofeng; Man Jongzai; Zhang Xiaomin; Yuan Jing; Yuan Xiaodong

    1998-01-01

    The author describes the application of successive quadratic programming method (SQP) to design laser beam configuration in target area. Based on the requirement of ICF experiment physics, a math model of indirect-driver beam geometry is given. A 3D wire-frame is plotted, in which support lines represent 60 laser entireties and 240 turning points of support lines' segments stand for the spatial positions of reflectors

  11. A novel graphical technique for Pinch Analysis applications: Energy Targets and grassroots design

    International Nuclear Information System (INIS)

    Gadalla, Mamdouh A.

    2015-01-01

    Graphical abstract: A new HEN graphical design. - Highlights: • A new graphical technique for heat exchanger networks design. • Pinch Analysis principles and design rules are better interpreted. • Graphical guidelines for optimum heat integration. • New temperature-based graphs provide user-interactive features. - Abstract: Pinch Analysis is for decades a leading tool to energy integration for retrofit and design. This paper presents a new graphical technique, based on Pinch Analysis, for the grassroots design of heat exchanger networks. In the new graph, the temperatures of hot streams are plotted versus those of the cold streams. The temperature–temperature based graph is constructed to include temperatures of hot and cold streams as straight lines, horizontal lines for hot streams, and vertical lines for cold streams. The graph is applied to determine the pinch temperatures and Energy Targets. It is then used to synthesise graphically a complete exchanger network, achieving the Energy Targets. Within the new graph, exchangers are represented by inclined straight lines, whose slopes are proportional to the ratio of heat capacities and flows. Pinch Analysis principles for design are easily interpreted using this new graphical technique to design a complete exchanger network. Network designs achieved by the new technique can guarantee maximum heat recovery. The new technique can also be employed to simulate basic designs of heat exchanger networks. The strengths of the new tool are that it is simply applied using computers, requires no commercial software, and can be used for academic purposes/engineering education

  12. Modern Prodrug Design for Targeted Oral Drug Delivery

    Directory of Open Access Journals (Sweden)

    Arik Dahan

    2014-10-01

    Full Text Available The molecular information that became available over the past two decades significantly influenced the field of drug design and delivery at large, and the prodrug approach in particular. While the traditional prodrug approach was aimed at altering various physiochemical parameters, e.g., lipophilicity and charge state, the modern approach to prodrug design considers molecular/cellular factors, e.g., membrane influx/efflux transporters and cellular protein expression and distribution. This novel targeted-prodrug approach is aimed to exploit carrier-mediated transport for enhanced intestinal permeability, as well as specific enzymes to promote activation of the prodrug and liberation of the free parent drug. The purpose of this article is to provide a concise overview of this modern prodrug approach, with useful successful examples for its utilization. In the past the prodrug approach used to be viewed as a last option strategy, after all other possible solutions were exhausted; nowadays this is no longer the case, and in fact, the prodrug approach should be considered already in the very earliest development stages. Indeed, the prodrug approach becomes more and more popular and successful. A mechanistic prodrug design that aims to allow intestinal permeability by specific transporters, as well as activation by specific enzymes, may greatly improve the prodrug efficiency, and allow for novel oral treatment options.

  13. RNAblueprint: flexible multiple target nucleic acid sequence design.

    Science.gov (United States)

    Hammer, Stefan; Tschiatschek, Birgit; Flamm, Christoph; Hofacker, Ivo L; Findeiß, Sven

    2017-09-15

    Realizing the value of synthetic biology in biotechnology and medicine requires the design of molecules with specialized functions. Due to its close structure to function relationship, and the availability of good structure prediction methods and energy models, RNA is perfectly suited to be synthetically engineered with predefined properties. However, currently available RNA design tools cannot be easily adapted to accommodate new design specifications. Furthermore, complicated sampling and optimization methods are often developed to suit a specific RNA design goal, adding to their inflexibility. We developed a C ++  library implementing a graph coloring approach to stochastically sample sequences compatible with structural and sequence constraints from the typically very large solution space. The approach allows to specify and explore the solution space in a well defined way. Our library also guarantees uniform sampling, which makes optimization runs performant by not only avoiding re-evaluation of already found solutions, but also by raising the probability of finding better solutions for long optimization runs. We show that our software can be combined with any other software package to allow diverse RNA design applications. Scripting interfaces allow the easy adaption of existing code to accommodate new scenarios, making the whole design process very flexible. We implemented example design approaches written in Python to demonstrate these advantages. RNAblueprint , Python implementations and benchmark datasets are available at github: https://github.com/ViennaRNA . s.hammer@univie.ac.at, ivo@tbi.univie.ac.at or sven@tbi.univie.ac.at. Supplementary data are available at Bioinformatics online. © The Author(s) 2017. Published by Oxford University Press.

  14. System requirements and design description for the environmental requirements management interface (ERMI)

    International Nuclear Information System (INIS)

    Biebesheimer, E.

    1997-01-01

    This document describes system requirements and the design description for the Environmental Requirements Management Interface (ERMI). The ERMI database assists Tank Farm personnel with scheduling, planning, and documenting procedure compliance, performance verification, and selected corrective action tracking activities for Tank Farm S/RID requirements. The ERMI database was developed by Science Applications International Corporation (SAIC). This document was prepared by SAIC and edited by LMHC

  15. Requirements of Integrated Design Teams While Evaluating Advanced Energy Retrofit Design Options in Immersive Virtual Environments

    Directory of Open Access Journals (Sweden)

    Xue Yang

    2015-12-01

    Full Text Available One of the significant ways to save energy use in buildings is to implement advanced energy retrofits in existing buildings. Improving energy performance of buildings through advanced energy retrofitting requires a clear understanding of the cost and energy implications of design alternatives from various engineering disciplines when different retrofit options are considered. The communication of retrofit design alternatives and their energy implications is essential in the decision-making process, as it affects the final retrofit selections and hence the energy efficiency of the retrofitted buildings. The objective of the research presented here was to identify a generic list of information requirements that are needed to be shared and collectively analyzed by integrated design teams during advanced energy retrofit design review meetings held in immersive settings. While identifying such requirements, the authors used an immersive environment based iterative requirements elicitation approach. The technology was used as a means to better identify the information requirements of integrated design teams to be analyzed as a group. This paper provides findings on information requirements of integrated design teams when evaluating retrofit options in immersive virtual environments. The information requirements were identified through interactions with sixteen experts in design and energy modeling domain, and validated with another group of participants consisting of six design experts who were experienced in integrated design processes. Industry practitioners can use the findings in deciding on what information to share with integrated design team members during design review meetings that utilize immersive virtual environments.

  16. An investigative approach to explore optimum assembly process design for annular targets carrying LEU foil

    Science.gov (United States)

    Hoyer, Annemarie

    Technetium-99m is the most widely used nuclear isotope in the medical field, with nearly 80 to 85% of all diagnostic imaging procedures. The daughter isotope of molybdenum-99 is currently produced using weapons-grade uranium. A suggested design for aluminum targets carrying low-enriched uranium (LEU) foil is presented for the fulfillment of eliminating highly enriched uranium (HEU) for medical isotope production. The assembly process that this research focuses on is the conventional draw-plug process which is currently used and lastly the sealing process. The research is unique in that it is a systematic approach to explore the optimal target assembly process to produce those targets with the required quality and integrity. Conducting 9 parametric experiments, aluminum tubes with a nickel foil fission-barrier and a surrogate stainless steel foil are assembled, welded and then examined to find defects, to determine residual stresses, and to find the best cost-effective target dimensions. The experimental design consists of 9 assembly combinations that were found through orthogonal arrays in order to explore the significance of each factor. Using probabilistic modeling, the parametric study is investigated using the Taguchi method of robust analysis. Depending on the situation, optimal conditions may be a nominal, a minimized or occasionally a maximized condition. The results will provide the best target design and will give optimal quality with little or no assembly defects.

  17. Design of an ignition target for the laser megajoule, mitigating parametric instabilities

    International Nuclear Information System (INIS)

    Laffite, S.; Loiseau, P.

    2010-01-01

    Laser plasma interaction (LPI) is a critical issue in ignition target design. Based on both scaling laws and two-dimensional calculations, this article describes how we can constrain a laser megajoule (LMJ) [J. Ebrardt and J. M. Chaput, J. Phys.: Conf. Ser. 112, 032005 (2008)] target design by mitigating LPI. An ignition indirect drive target has been designed for the 2/3 LMJ step. It requires 0.9 MJ and 260 TW of laser energy and power, to achieve a temperature of 300 eV in a rugby-shaped Hohlraum and give a yield of about 20 MJ. The study focuses on the analysis of linear gain for stimulated Raman and Brillouin scatterings. Enlarging the focal spot is an obvious way to reduce linear gains. We show that this reduction is nonlinear with the focal spot size. For relatively small focal spot area, linear gains are significantly reduced by enlarging the focal spot. However, there is no benefit in too large focal spots because of necessary larger laser entrance holes, which require more laser energy. Furthermore, this leads to the existence, for a given design, of a minimum value for linear gains for which we cannot go below.

  18. Design of an ignition target for the laser megajoule, mitigating parametric instabilities

    Science.gov (United States)

    Laffite, S.; Loiseau, P.

    2010-10-01

    Laser plasma interaction (LPI) is a critical issue in ignition target design. Based on both scaling laws and two-dimensional calculations, this article describes how we can constrain a laser megajoule (LMJ) [J. Ebrardt and J. M. Chaput, J. Phys.: Conf. Ser. 112, 032005 (2008)] target design by mitigating LPI. An ignition indirect drive target has been designed for the 2/3 LMJ step. It requires 0.9 MJ and 260 TW of laser energy and power, to achieve a temperature of 300 eV in a rugby-shaped Hohlraum and give a yield of about 20 MJ. The study focuses on the analysis of linear gain for stimulated Raman and Brillouin scatterings. Enlarging the focal spot is an obvious way to reduce linear gains. We show that this reduction is nonlinear with the focal spot size. For relatively small focal spot area, linear gains are significantly reduced by enlarging the focal spot. However, there is no benefit in too large focal spots because of necessary larger laser entrance holes, which require more laser energy. Furthermore, this leads to the existence, for a given design, of a minimum value for linear gains for which we cannot go below.

  19. Design Requirements for Communication-Intensive Interactive Applications

    Science.gov (United States)

    Bolchini, Davide; Garzotto, Franca; Paolini, Paolo

    Online interactive applications call for new requirements paradigms to capture the growing complexity of computer-mediated communication. Crafting successful interactive applications (such as websites and multimedia) involves modeling the requirements for the user experience, including those leading to content design, usable information architecture and interaction, in profound coordination with the communication goals of all stakeholders involved, ranging from persuasion to social engagement, to call for action. To face this grand challenge, we propose a methodology for modeling communication requirements and provide a set of operational conceptual tools to be used in complex projects with multiple stakeholders. Through examples from real-life projects and lessons-learned from direct experience, we draw on the concepts of brand, value, communication goals, information and persuasion requirements to systematically guide analysts to master the multifaceted connections of these elements as drivers to inform successful communication designs.

  20. Identifying and Managing Engineering Design Requirements for Emerging Markets

    DEFF Research Database (Denmark)

    Li, Xuemeng

    , especially for those companies originally from developed markets, to acquire an in-depth understanding of particular design requirements in emerging markets in order to adapt both company products and approaches in such contexts. Prior studies on the identification and management of design requirements have...... predominantly been conducted in the context of developed countries and relatively affluent markets. Emerging markets are distinct from developed markets in terms of numerous contextual factors, e.g., regulatory environments and competitive landscapes. These factors influence the requirement identification...... attention. There is a need for an overview of different perspectives in requirement identification for manufacturing companies and their corresponding assessments in the context of emerging markets. Therefore, this research project is motivated to 1) investigate the process of identifying and managing...

  1. Design of Thymidine Analogues Targeting Thymidilate Kinase of Mycobacterium tuberculosis

    Directory of Open Access Journals (Sweden)

    Luc Calvin Owono Owono

    2013-01-01

    Full Text Available We design here new nanomolar antituberculotics, inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase (TMPKmt, by means of structure-based molecular design. 3D models of TMPKmt-inhibitor complexes have been prepared from the crystal structure of TMPKmt cocrystallized with the natural substrate deoxythymidine monophosphate (dTMP (1GSI for a training set of 15 thymidine analogues (TMDs with known activity to prepare a QSAR model of interaction establishing a correlation between the free energy of complexation and the biological activity. Subsequent validation of the predictability of the model has been performed with a 3D QSAR pharmacophore generation. The structural information derived from the model served to design new subnanomolar thymidine analogues. From molecular modeling investigations, the agreement between free energy of complexation (ΔΔGcom and Ki values explains 94% of the TMPKmt inhibition (pKi=-0.2924ΔΔGcom+3.234;R2=0.94 by variation of the computed ΔΔGcom and 92% for the pharmacophore (PH4 model (pKi=1.0206×pKipred-0.0832,  R2=0.92. The analysis of contributions from active site residues suggested substitution at the 5-position of pyrimidine ring and various groups at the 5′-position of the ribose. The best inhibitor reached a predicted Ki of 0.155 nM. The computational approach through the combined use of molecular modeling and PH4 pharmacophore is helpful in targeted drug design, providing valuable information for the synthesis and prediction of activity of novel antituberculotic agents.

  2. Working group 4B - human intrusion: Design/performance requirements

    International Nuclear Information System (INIS)

    Channell, J.

    1993-01-01

    There is no summary of the progress made by working group 4B (Human Intrusion: Design/performance Requirements) during the Electric Power Research Institute's EPRI Workshop on the technical basis of EPA HLW Disposal Criteria, March 1993. This group was to discuss the waste disposal standard, 40 CFR Part 191, in terms of the design and performance requirements of human intrusion. Instead, because there were so few members, they combined with working group 4A and studied the three-tier approach to evaluating postclosure performance

  3. Design Requirements, Epistemic Uncertainty and Solution Development Strategies in Software Design

    DEFF Research Database (Denmark)

    Ball, Linden J.; Onarheim, Balder; Christensen, Bo Thomas

    2010-01-01

    This paper investigates the potential involvement of “epistemic uncertainty” in mediating between complex design requirements and strategic switches in software design strategies. The analysis revealed that the designers produced an initial “first-pass” solution to the given design brief in a bre...... a view of software design as involving a mixed breadth-first and depth-first solution development approach, with strategic switching to depth-first design being triggered by requirement complexity and being mediated by associated feelings of uncertainty....

  4. Smart Contract Templates: essential requirements and design options

    OpenAIRE

    Clack, Christopher D.; Bakshi, Vikram A.; Braine, Lee

    2016-01-01

    Smart Contract Templates support legally-enforceable smart contracts, using operational parameters to connect legal agreements to standardised code. In this paper, we explore the design landscape of potential formats for storage and transmission of smart legal agreements. We identify essential requirements and describe a number of key design options, from which we envisage future development of standardised formats for defining and manipulating smart legal agreements. This provides a prelimin...

  5. Design of a distributed radiator target for inertial fusion driven from two sides with heavy ion beams

    International Nuclear Information System (INIS)

    Tabak, M.; Callahan-Miller, D.

    1997-01-01

    We describe the status of a distributed radiator heavy ion target design. In integrated calculations this target ignited and produced 390-430 MJ of yieldwhen driven with 5.8-6.5 MJ of 3-4 GeV Pb ions. The target has cylindrical symmetry with disk endplates. The ions uniformly illuminate these endplates in a 5mm radius spot. We discuss the considerations which led to this design together with some previously unused design features: low density hohlraum walls in approximate pressure balance with internal low-Z fill materials, radiationsymmetry determined by the position of the radiator materials and particle ranges, and early time pressure symmetry possibly influenced by radiation shims. We discuss how this target scales to lower input energy or to lower beam power. Variant designs with more realistic beam focusing strategies are also discussed. We show the tradeoffs required for targets which accept higher particle energies

  6. REQUIREMENTS PROCESSING TOOLS AND THE BUILDING DESIGNERS MOTIVATION ON USE

    Directory of Open Access Journals (Sweden)

    Camila Pegoraro

    2017-04-01

    Full Text Available The successful development of projects requires, among other conditions, the ability to process requirements. In the construction literature, researchers have figured out that human difficulties was often at the root of Requirements Processing (RP problems throughout the design phases, and that the employment of tools could be a key factor for RP implementation. To check these outcomes and to look at how current practitioners behave in relation to the RP tools, an exploratory case study was conducted with a building design team from a public university. The aim of this paper was to investigate the perception of benefits and the motivation of designers regarding the RP tools. The results indicated that 42% of the participants are highly motivated to use new tools and that they have more interest in tools that deal directly with design activities than in those focused on data. Validation tools aroused interest as the most useful tools for designers. 66,7% of the participants mentioned that the tools can make the design process clearer, and that training and adaptation are crucial to promote acceptance and commitment to RP. The main contribution is the indication of gaps for further research and for tools improvement from the designers’ perspective.

  7. Design requirements of communication architecture of SMART safety system

    International Nuclear Information System (INIS)

    Park, H. Y.; Kim, D. H.; Sin, Y. C.; Lee, J. Y.

    2001-01-01

    To develop the communication network architecture of safety system of SMART, the evaluation elements for reliability and performance factors are extracted from commercial networks and classified the required-level by importance. A predictable determinacy, status and fixed based architecture, separation and isolation from other systems, high reliability, verification and validation are introduced as the essential requirements of safety system communication network. Based on the suggested requirements, optical cable, star topology, synchronous transmission, point-to-point physical link, connection-oriented logical link, MAC (medium access control) with fixed allocation are selected as the design elements. The proposed architecture will be applied as basic communication network architecture of SMART safety system

  8. Design requirements for new nuclear reactor facilities in Canada

    International Nuclear Information System (INIS)

    Shim, S.; Ohn, M.; Harwood, C.

    2012-01-01

    The Canadian Nuclear Safety Commission (CNSC) has been establishing the regulatory framework for the efficient and effective licensing of new nuclear reactor facilities. This regulatory framework includes the documentation of the requirements for the design and safety analysis of new nuclear reactor facilities, regardless of size. For this purpose, the CNSC has published the design and safety analysis requirements in the following two sets of regulatory documents: 1. RD-337, Design of New Nuclear Power Plants and RD-310, Safety Analysis for Nuclear Power Plants; and 2. RD-367, Design of Small Reactor Facilities and RD-308, Deterministic Safety Analysis for Small Reactor Facilities. These regulatory documents have been modernized to document past practices and experience and to be consistent with national and international standards. These regulatory documents provide the requirements for the design and safety analysis at a high level presented in a hierarchical structure. These documents were developed in a technology neutral approach so that they can be applicable for a wide variety of water cooled reactor facilities. This paper highlights two particular aspects of these regulatory documents: The use of a graded approach to make the documents applicable for a wide variety of nuclear reactor facilities including nuclear power plants (NPPs) and small reactor facilities; and, Design requirements that are new and different from past Canadian practices. Finally, this paper presents some of the proposed changes in RD-337 to implement specific details of the recommendations of the CNSC Fukushima Task Force Report. Major changes were not needed as the 2008 version of RD-337 already contained requirements to address most of the lessons learned from the Fukushima event of March 2011. (author)

  9. Engineered barrier systems (EBS): design requirements and constraints

    International Nuclear Information System (INIS)

    2004-01-01

    A joint NEA-EC workshop entitled 'Engineered Barrier Systems: Design Requirements and Constraints' was organised in Turku, Finland on 26-29 August 2003 and hosted by Posiva Oy. The main objectives of the workshop were to promote interaction and collaboration among experts responsible for engineering design and safety assessment in order to develop a greater understanding of how to achieve the integration needed for the successful design of engineered barrier systems, and to clarify the role that an EBS can play in the overall safety case for a repository. These proceedings present the outcomes of this workshop. (author)

  10. Future CANDU nuclear power plant design requirements document executive summary

    International Nuclear Information System (INIS)

    Lee, Duk Su; Chang, Woo Hyun; Lee, Nam Young; S. A. Usmani

    1996-03-01

    The future CANDU Requirements Document (FCRED) describes a clear and complete statement of utility requirements for the next generation of CANDU nuclear power plants including those in Korea. The requirements are based on proven technology of PHWR experience and are intended to be consistent with those specified in the current international requirement documents. Furthermore, these integrated set of design requirements, incorporate utility input to the extent currently available and assure a simple, robust and more forgiving design that enhances the performance and safety. The FCRED addresses the entire plant, including the nuclear steam supply system and the balance of the plant, up to the interface with the utility grid at the distribution side of the circuit breakers which connect the switchyard to the transmission lines. Requirements for processing of low level radioactive waste at the plant site and spent fuel storage requirements are included in the FCRED. Off-site waste disposal is beyond the scope of the FCRED. 2 tabs., 1 fig. (Author) .new

  11. IT Requirements Integration in High-Rise Construction Design Projects

    Science.gov (United States)

    Levina, Anastasia; Ilin, Igor; Esedulaev, Rustam

    2018-03-01

    The paper discusses the growing role of IT support for the operation of modern high-rise buildings, due to the complexity of managing engineering systems of buildings and the requirements of consumers for the IT infrastructure. The existing regulatory framework for the development of design documentation for construction, including high-rise buildings, is analyzed, and the lack of coherence in the development of this documentation with the requirements for the creation of an automated management system and the corresponding IT infrastructure is stated. The lack of integration between these areas is the cause of delays and inefficiencies both at the design stage and at the stage of putting the building into operation. The paper proposes an approach to coordinate the requirements of the IT infrastructure of high-rise buildings and design documentation for construction. The solution to this problem is possible within the framework of the enterprise architecture concept by coordinating the requirements of the IT and technological layers at the design stage of the construction.

  12. Robot-Assisted Fracture Surgery: Surgical Requirements and System Design.

    Science.gov (United States)

    Georgilas, Ioannis; Dagnino, Giulio; Tarassoli, Payam; Atkins, Roger; Dogramadzi, Sanja

    2018-03-09

    The design of medical devices is a complex and crucial process to ensure patient safety. It has been shown that improperly designed devices lead to errors and associated accidents and costs. A key element for a successful design is incorporating the views of the primary and secondary stakeholders early in the development process. They provide insights into current practice and point out specific issues with the current processes and equipment in use. This work presents how information from a user-study conducted in the early stages of the RAFS (Robot Assisted Fracture Surgery) project informed the subsequent development and testing of the system. The user needs were captured using qualitative methods and converted to operational, functional, and non-functional requirements based on the methods derived from product design and development. This work presents how the requirements inform a new workflow for intra-articular joint fracture reduction using a robotic system. It is also shown how the various elements of the system are developed to explicitly address one or more of the requirements identified, and how intermediate verification tests are conducted to ensure conformity. Finally, a validation test in the form of a cadaveric trial confirms the ability of the designed system to satisfy the aims set by the original research question and the needs of the users.

  13. Lumican Peptides: Rational Design Targeting ALK5/TGFBRI

    Science.gov (United States)

    Gesteira, Tarsis Ferreira; Coulson-Thomas, Vivien J.; Yuan, Yong; Zhang, Jianhua; Nader, Helena B.; Kao, Winston W.-Y.

    2017-02-01

    Lumican, a small leucine rich proteoglycan (SLRP), is a component of extracellular matrix which also functions as a matrikine regulating multiple cell activities. In the cornea, lumican maintains corneal transparency by regulating collagen fibrillogenesis, promoting corneal epithelial wound healing, regulating gene expression and maintaining corneal homeostasis. We have recently shown that a peptide designed from the 13 C-terminal amino acids of lumican (LumC13) binds to ALK5/TGFBR1 (type1 receptor of TGFβ) to promote wound healing. Herein we evaluate the mechanism by which this synthetic C-terminal amphiphilic peptide (LumC13), binds to ALK5. These studies clearly reveal that LumC13-ALK5 form a stable complex. In order to determine the minimal amino acids required for the formation of a stable lumican/ALK5 complex derivatives of LumC13 were designed and their binding to ALK5 investigated in silico. These LumC13 derivatives were tested both in vitro and in vivo to evaluate their ability to promote corneal epithelial cell migration and corneal wound healing, respectively. These validations add to the therapeutic value of LumC13 (Lumikine) and aid its clinical relevance of promoting the healing of corneal epithelium debridement. Moreover, our data validates the efficacy of our computational approach to design active peptides based on interactions of receptor and chemokine/ligand.

  14. Target design for high fusion yield with the double Z-pinch-driven hohlraum

    International Nuclear Information System (INIS)

    Vesey, R. A.; Herrmann, M. C.; Lemke, R. W.; Desjarlais, M. P.; Cuneo, M. E.; Stygar, W. A.; Bennett, G. R.; Campbell, R. B.; Christenson, P. J.; Mehlhorn, T. A.; Porter, J. L.; Slutz, S. A.

    2007-01-01

    A key demonstration on the path to inertial fusion energy is the achievement of high fusion yield (hundreds of MJ) and high target gain. Toward this goal, an indirect-drive high-yield inertial confinement fusion (ICF) target involving two Z-pinch x-ray sources heating a central secondary hohlraum is described by Hammer et al. [Phys. Plasmas 6, 2129 (1999)]. In subsequent research at Sandia National Laboratories, theoretical/computational models have been developed and an extensive series of validation experiments have been performed to study hohlraum energetics, capsule coupling, and capsule implosion symmetry for this system. These models have been used to design a high-yield Z-pinch-driven ICF target that incorporates the latest experience in capsule design, hohlraum symmetry control, and x-ray production by Z pinches. An x-ray energy output of 9 MJ per pinch, suitably pulse-shaped, is sufficient for this concept to drive 0.3-0.5 GJ capsules. For the first time, integrated two-dimensional (2D) hohlraum/capsule radiation-hydrodynamics simulations have demonstrated adequate hohlraum coupling, time-dependent radiation symmetry control, and the successful implosion, ignition, and burn of a high-yield capsule in the double Z-pinch hohlraum. An important new feature of this target design is mode-selective symmetry control: the use of burn-through shields offset from the capsule that selectively tune certain low-order asymmetry modes (P 2 ,P 4 ) without significantly perturbing higher-order modes and without a significant energy penalty. This paper will describe the capsule and hohlraum design that have produced 0.4-0.5 GJ yields in 2D simulations, provide a preliminary estimate of the Z-pinch load and accelerator requirements necessary to drive the system, and suggest future directions for target design work

  15. GLRS-R 2-colour retroreflector target design and predicted performance

    Science.gov (United States)

    Lund, Glenn

    1993-01-01

    This paper reports on the retroreflector ground-target design for the GLRS-R spaceborne dual-wavelength laser ranging system. The described passive design flows down from the requirements of high station autonomy, high global FOV (up to 60 degrees zenith angle), little or no multiple pulse returns, and adequate optical cross section for most ranging geometries. The proposed solution makes use of 5 hollow cube-corner retroreflectors of which one points to the zenith and the remaining four are inclined from the vertical at uniform azimuthal spacings. The need for fairly large (is approximately 10 cm) retroreflectors is expected (within turbulence limitations) to generate quite narrow diffraction lobes, thus placing non-trivial requirements on the vectorial accuracy of velocity aberration corrections. A good compromise solution is found by appropriately spoiling just one of the retroreflector dihedral angles from 90 degrees, thus generating two symmetrically oriented diffraction lobes in the return beam. The required spoil angles are found to have little dependence on ground target latitude. Various link budget analyses are presented, showing the influence of such factors as point-ahead optimization, turbulence, ranging angle, atmospheric visibility and ground target thermal deformations.

  16. Recycling issues facing target and RTL materials of inertial fusion designs

    International Nuclear Information System (INIS)

    El-Guebaly, L.; Wilson, P.; Sawan, M.; Henderson, D.; Varuttamaseni, A.

    2005-01-01

    Designers of heavy ion (HI) and Z-pinch inertial fusion power plants have explored the potential of recycling the target and recyclable transmission line (RTL) materials as an alternate option to disposal in a geological repository. This work represents the first time a comprehensive recycling assessment was performed on both machines with an exact pulse history. Our results offer two divergent conclusions on the recycling issue. For the HI concept, target recycling is not a 'must' requirement and the preferred option is the one-shot use scenario as target materials represent a small waste stream, less than 1% of the total nuclear island waste. We recommend using low-cost hohlraum materials once-through and then disposing of them instead of recycling expensive materials such as Au and Gd. On the contrary, RTL recycling is a 'must' requirement for the Z-pinch concept in order to minimize the RTL inventory and enhance the economics. The RTLs meet the low level waste and recycling dose requirements with a wide margin when recycled for the entire plant life even without a cooling period. While recycling offers advantages to the Z-pinch system, it adds complexity and cost to the HI designs

  17. Primary design of Si cooling arm structure in ICF cryogenic target

    International Nuclear Information System (INIS)

    Zhang Yong; Yi Yong; Tang Changhuan; Zhang Jicheng

    2013-01-01

    According to the requirement of the cryogenic target system to the Si cooling arm structure, the Si cooling arm was primarily designed based on the USA National Ignition Facility (NIF) target. A new three-dimensional model of Si cooling arm was developed by SolidWorks software, and the simulation and analysis of Si cooling arm in aspect of mechanical property, thermal response and assembly were made based on the model. A law about the effect of the arm length of Si cooling arm and the width and the length of bifurcation on Si cooling arm was achieved. The research may provide the theoretical foundation and reference for the further improvement of cryogenic target. (authors)

  18. TRAC analysis of design basis events for the accelerator production of tritium target/blanket

    International Nuclear Information System (INIS)

    Lin, J.C.; Elson, J.

    1997-01-01

    A two-loop primary cooling system with a residual heat removal system was designed to mitigate the heat generated in the tungsten neutron source rods inside the rungs of the ladders and the shell of the rungs. The Transient Reactor Analysis Code (TRAC) was used to analyze the thermal-hydraulic behavior of the primary cooling system during a pump coastdown transient; a cold-leg, large-break loss-of-coolant accident (LBLOCA); a hot-leg LBLOCA; and a target downcomer LBLOCA. The TRAC analysis results showed that the heat generated in the tungsten neutron source rods can be mitigated by the primary cooling system for the pump coastdown transient and all the LBLOCAs except the target downcomer LBLOCA. For the target downcomer LBLOCA, a cavity flood system is required to fill the cavity with water at a level above the large fixed headers

  19. Validation of a new design of tellurium dioide-irradiated target

    Energy Technology Data Exchange (ETDEWEB)

    Fllaoui, Aziz; Ghamad, Younes; Zoubir, Brahim; Ayaz, Zinel Abidine; El Morabiti, Aissam; Amayoud, Hafid [Centre National de l' Energie des Sciences et des Techniques Nucleaires, Rabat (Morocco); Chakir, El Mahjoub [Nuclear Physics Department, University Ibn Toufail, Kenitra (Morocco)

    2016-10-15

    Production of iodine-131 by neutron activation of tellurium in tellurium dioxide (TeO{sub 2}) material requires a target that meets the safety requirements. In a radiopharmaceutical production unit, a new lid for a can was designed, which permits tight sealing of the target by using tungsten inert gas welding. The leakage rate of all prepared targets was assessed using a helium mass spectrometer. The accepted leakage rate is ≤ 10 - 4 mbr.L/s, according to the approved safety report related to iodine-131 production in the TRIGA Mark II research reactor (TRIGA: Training, Research, Isotopes, General Atomics). To confirm the resistance of the new design to the irradiation conditions in the TRIGA Mark II research reactor's central thimble, a study of heat effect on the sealed targets for 7 hours in an oven was conducted and the leakage rates were evaluated. The results show that the tightness of the targets is ensured up to 600 .deg. C with the appearance of deformations on lids beyond 450 .deg. C. The study of heat transfer through the target was conducted by adopting a one-dimensional approximation, under consideration of the three transfer modes-convection, conduction, and radiation. The quantities of heat generated by gamma and neutron heating were calculated by a validated computational model for the neutronic simulation of the TRIGA Mark II research reactor using the Monte Carlo N-Particle transport code. Using the heat transfer equations according to the three modes of heat transfer, the thermal study of I-131 production by irradiation of the target in the central thimble showed that the temperatures of materials do not exceed the corresponding melting points. To validate this new design, several targets have been irradiated in the central thimble according to a preplanned irradiation program, going from 4 hours of irradiation at a power level of 0.5 MW up to 35 hours (7 h/d for 5 days a week) at 1.5 MW. The results show that the irradiated targets are

  20. Validation of a New Design of Tellurium Dioxide-Irradiated Target

    Directory of Open Access Journals (Sweden)

    Aziz Fllaoui

    2016-10-01

    Full Text Available Production of iodine-131 by neutron activation of tellurium in tellurium dioxide (TeO2 material requires a target that meets the safety requirements. In a radiopharmaceutical production unit, a new lid for a can was designed, which permits tight sealing of the target by using tungsten inert gas welding. The leakage rate of all prepared targets was assessed using a helium mass spectrometer. The accepted leakage rate is ≤ 10−4 mbr.L/s, according to the approved safety report related to iodine-131 production in the TRIGA Mark II research reactor (TRIGA: Training, Research, Isotopes, General Atomics. To confirm the resistance of the new design to the irradiation conditions in the TRIGA Mark II research reactor's central thimble, a study of heat effect on the sealed targets for 7 hours in an oven was conducted and the leakage rates were evaluated. The results show that the tightness of the targets is ensured up to 600°C with the appearance of deformations on lids beyond 450°C. The study of heat transfer through the target was conducted by adopting a one-dimensional approximation, under consideration of the three transfer modes—convection, conduction, and radiation. The quantities of heat generated by gamma and neutron heating were calculated by a validated computational model for the neutronic simulation of the TRIGA Mark II research reactor using the Monte Carlo N-Particle transport code. Using the heat transfer equations according to the three modes of heat transfer, the thermal study of I-131 production by irradiation of the target in the central thimble showed that the temperatures of materials do not exceed the corresponding melting points. To validate this new design, several targets have been irradiated in the central thimble according to a preplanned irradiation program, going from 4 hours of irradiation at a power level of 0.5 MW up to 35 hours (7 h/d for 5 days a week at 1.5 MW. The results show that the irradiated targets are

  1. Safety of nuclear power plants: Design. Safety requirements

    International Nuclear Information System (INIS)

    2000-01-01

    The present publication supersedes the Code on the Safety of Nuclear Power Plants: Design (Safety Series No. 50-C-D (Rev. 1), issued in 1988). It takes account of developments relating to the safety of nuclear power plants since the Code on Design was last revised. These developments include the issuing of the Safety Fundamentals publication, The Safety of Nuclear Installations, and the present revision of various safety standards and other publications relating to safety. Requirements for nuclear safety are intended to ensure adequate protection of site personnel, the public and the environment from the effects of ionizing radiation arising from nuclear power plants. It is recognized that technology and scientific knowledge advance, and nuclear safety and what is considered adequate protection are not static entities. Safety requirements change with these developments and this publication reflects the present consensus. This Safety Requirements publication takes account of the developments in safety requirements by, for example, including the consideration of severe accidents in the design process. Other topics that have been given more detailed attention include management of safety, design management, plant ageing and wearing out effects, computer based safety systems, external and internal hazards, human factors, feedback of operational experience, and safety assessment and verification. This publication establishes safety requirements that define the elements necessary to ensure nuclear safety. These requirements are applicable to safety functions and the associated structures, systems and components, as well as to procedures important to safety in nuclear power plants. It is expected that this publication will be used primarily for land based stationary nuclear power plants with water cooled reactors designed for electricity generation or for other heat production applications (such as district heating or desalination). It is recognized that in the case of

  2. Safety of nuclear power plants: Design. Safety requirements

    International Nuclear Information System (INIS)

    2004-01-01

    The present publication supersedes the Code on the Safety of Nuclear Power Plants: Design (Safety Series No. 50-C-D (Rev. 1), issued in 1988). It takes account of developments relating to the safety of nuclear power plants since the Code on Design was last revised. These developments include the issuing of the Safety Fundamentals publication, The Safety of Nuclear Installations, and the present revision of various safety standards and other publications relating to safety. Requirements for nuclear safety are intended to ensure adequate protection of site personnel, the public and the environment from the effects of ionizing radiation arising from nuclear power plants. It is recognized that technology and scientific knowledge advance, and nuclear safety and what is considered adequate protection are not static entities. Safety requirements change with these developments and this publication reflects the present consensus. This Safety Requirements publication takes account of the developments in safety requirements by, for example, including the consideration of severe accidents in the design process. Other topics that have been given more detailed attention include management of safety, design management, plant ageing and wearing out effects, computer based safety systems, external and internal hazards, human factors, feedback of operational experience, and safety assessment and verification. This publication establishes safety requirements that define the elements necessary to ensure nuclear safety. These requirements are applicable to safety functions and the associated structures, systems and components, as well as to procedures important to safety in nuclear power plants. It is expected that this publication will be used primarily for land based stationary nuclear power plants with water cooled reactors designed for electricity generation or for other heat production applications (such as district heating or desalination). It is recognized that in the case of

  3. SNS Target Test Facility for remote handling design and verification

    International Nuclear Information System (INIS)

    Spampinato, P.T.; Graves, V.B.; Schrock, S.L.

    1998-01-01

    The Target Test Facility will be a full-scale prototype of the Spallation Neutron Source Target Station. It will be used to demonstrate remote handling operations on various components of the mercury flow loop and for thermal/hydraulic testing. This paper describes the remote handling aspects of the Target Test Facility. Since the facility will contain approximately 1 cubic meter of mercury for the thermal/hydraulic tests, an enclosure will also be constructed that matches the actual Target Test Cell

  4. Design of a control system for HIRFL-CSRe internal target facility in Lanzhou

    International Nuclear Information System (INIS)

    Wang Yanyu; Liu Wufeng; Shao Caojie; Lin Feiyu; Zhang Jianchuan; Xiao Wenjun

    2010-01-01

    It is described in this paper the design of the control system for HIRFL-CSRe internal target facility, in which there are many different kinds of units need to be monitored and controlled. The control system is composed of several subsystems which are designed to control the gas-jet temperature, chamber vacuum, valves and molecular pumps. A human-computer interaction interface is also realized to do the data acquisition, data processing and display. The whole system has been working stably and safely, it fully meets the requirements of physical experiments in the internal target facility. In January of 2010, the first physics experiment of the radioactive electron capture was finished successfully with the aids of this control system. (authors)

  5. Process of establishing design requirements and selecting alternative configurations for conceptual design of a VLA

    Directory of Open Access Journals (Sweden)

    Bo-Young Bae

    2017-04-01

    Full Text Available In this study, a process for establishing design requirements and selecting alternative configurations for the conceptual phase of aircraft design has been proposed. The proposed process uses system-engineering-based requirement-analysis techniques such as objective tree, analytic hierarchy process, and quality function deployment to establish logical and quantitative standards. Moreover, in order to perform a logical selection of alternative aircraft configurations, it uses advanced decision-making methods such as morphological matrix and technique for order preference by similarity to the ideal solution. In addition, a preliminary sizing tool has been developed to check the feasibility of the established performance requirements and to evaluate the flight performance of the selected configurations. The present process has been applied for a two-seater very light aircraft (VLA, resulting in a set of tentative design requirements and two families of VLA configurations: a high-wing configuration and a low-wing configuration. The resulting set of design requirements consists of three categories: customer requirements, certification requirements, and performance requirements. The performance requirements include two mission requirements for the flight range and the endurance by reflecting the customer requirements. The flight performances of the two configuration families were evaluated using the sizing tool developed and the low-wing configuration with conventional tails was selected as the best baseline configuration for the VLA.

  6. Preliminary Design Requirements Document for Project W-314

    Energy Technology Data Exchange (ETDEWEB)

    MCGREW, D.L.

    2000-04-27

    This document sets forth functional requirements, performance requirements, and design constraints for the tank farm systems elements identified in Section 3.1 of this document. These requirements shall be used to develop the Design Requirements Baseline for those system elements. System Overview--The tank farm system at Hanford Site currently consists of 149 single shell tanks and 28 double shell tanks with associated facilities and equipment, located in 18 separate groupings. Each grouping is known as a tank farm. They are located in the areas designated as 200 West and 200 East. Table 1-1 shows the number of tanks in each farm. The farms are connected together through a transfer system consisting of piping, diversion boxes, Double Contained Receiver Tanks (DCRT) and other miscellaneous facilities and elements. The tank farm system also connects to a series of processing plants which generate radioactive and hazardous wastes. The primary functions of the tank farm system are to store, transfer, concentrate, and characterize radioactive and hazardous waste generated at Hanford, until the waste can be safely retrieved, processed and dispositioned. The systems provided by Project W-314 support the store and transfer waste functions. The system elements to be upgraded by Project W-314 are identified in Section 3.1.

  7. Data Requirements and the Basis for Designing Health Information Kiosks.

    Science.gov (United States)

    Afzali, Mina; Ahmadi, Maryam; Mahmoudvand, Zahra

    2017-09-01

    Health kiosks are an innovative and cost-effective solution that organizations can easily implement to help educate people. To determine the data requirements and basis for designing health information kiosks as a new technology to maintain the health of society. By reviewing the literature, a list of information requirements was provided in 4 sections (demographic information, general information, diagnostic information and medical history), and questions related to the objectives, data elements, stakeholders, requirements, infrastructures and the applications of health information kiosks were provided. In order to determine the content validity of the designed set, the opinions of 2 physicians and 2 specialists in medical informatics were obtained. The test-retest method was used to measure its reliability. Data were analyzed using SPSS software. In the proposed model for Iran, 170 data elements in 6 sections were presented for experts' opinion, which ultimately, on 106 elements, a collective agreement was reached. To provide a model of health information kiosk, creating a standard data set is a critical point. According to a survey conducted on the various literature review studies related to the health information kiosk, the most important components of a health information kiosk include six categories; information needs, data elements, applications, stakeholders, requirements and infrastructure of health information kiosks that need to be considered when designing a health information kiosk.

  8. Preliminary Design Requirements Document for Project W-314

    International Nuclear Information System (INIS)

    MCGREW, D.L.

    2000-01-01

    This document sets forth functional requirements, performance requirements, and design constraints for the tank farm systems elements identified in Section 3.1 of this document. These requirements shall be used to develop the Design Requirements Baseline for those system elements. System Overview--The tank farm system at Hanford Site currently consists of 149 single shell tanks and 28 double shell tanks with associated facilities and equipment, located in 18 separate groupings. Each grouping is known as a tank farm. They are located in the areas designated as 200 West and 200 East. Table 1-1 shows the number of tanks in each farm. The farms are connected together through a transfer system consisting of piping, diversion boxes, Double Contained Receiver Tanks (DCRT) and other miscellaneous facilities and elements. The tank farm system also connects to a series of processing plants which generate radioactive and hazardous wastes. The primary functions of the tank farm system are to store, transfer, concentrate, and characterize radioactive and hazardous waste generated at Hanford, until the waste can be safely retrieved, processed and dispositioned. The systems provided by Project W-314 support the store and transfer waste functions. The system elements to be upgraded by Project W-314 are identified in Section 3.1

  9. Science requirements and the design of cabled ocean observatories

    Directory of Open Access Journals (Sweden)

    H. Mikada

    2006-06-01

    Full Text Available The ocean sciences are beginning a new phase in which scientists will enter the ocean environment and adaptively observe the Earth-Ocean system through remote control of sensors and sensor platforms. This new ocean science paradigm will be implemented using innovative facilities called ocean observatories which provide unprecedented levels of power and communication to access and manipulate real-time sensor networks deployed within many different environments in the ocean basins. Most of the principal design drivers for ocean observatories differ from those for commercial submarine telecommunications systems. First, ocean observatories require data to be input and output at one or more seafloor nodes rather than at a few land terminuses. Second, ocean observatories must distribute a lot of power to the seafloor at variable and fluctuating rates. Third, the seafloor infrastructure for an ocean observatory inherently requires that the wet plant be expandable and reconfigurable. Finally, because the wet communications and power infrastructure is comparatively complex, ocean observatory infrastructure must be designed for low life cycle cost rather than zero maintenance. The origin of these differences may be understood by taking a systems engineering approach to ocean observatory design through examining the requirements derived from science and then going through the process of iterative refinement to yield conceptual and physical designs. This is illustrated using the NEPTUNE regional cabled observatory power and data communications sub-systems.

  10. NIF target area design support. Final summary report

    International Nuclear Information System (INIS)

    Tokheim, R.E.; Seaman, L.; Curran, D.R.

    1996-02-01

    SRI International continued support work for the National Ignition Facility, Chamber Dynamics Group at Lawrence Livermore National Laboratory (LLNL). The work entailed computational modeling of shrapnel and debris generation from copper shine shields, hohlraum, and stainless steel cryogenic support tubes for 1.8 MJ and 1.0 MJ no-yield and 20 MJ yield shots. Also, the authors addressed the effects of shrapnel at the first wall. Computations for 1.8 MJ showed an ionized gold hohlraum, but about half solid and half ionized copper shine shields, when material cell phase boundaries were maintained. This debris generation represents a potential threat to the first wall and debris shields. Further work is required to translate these results into particle size distributions based on computed strain rates. The authors used simple algorithms for x-ray loading of frost layers protecting the target support to compute peak stress attenuation. They developed algorithmic formulas for predicting damage in candidate first wall materials and they found damage algorithms for fused-silica debris shield material. They obtained very preliminary computational results at 20 MJ for predicting shrapnel mass and particle density at the first wall in spherical polar coordinate space with the hohlraum axis as the polar direction

  11. Designing block copolymer architectures for targeted membrane performance

    KAUST Repository

    Dorin, Rachel Mika

    2014-01-01

    Using a combination of block copolymer self-assembly and non-solvent induced phase separation, isoporous ultrafiltration membranes were fabricated from four poly(isoprene-b-styrene-b-4-vinylpyridine) triblock terpolymers with similar block volume fractions but varying in total molar mass from 43 kg/mol to 115 kg/mol to systematically study the effect of polymer size on membrane structure. Small-angle X-ray scattering was used to probe terpolymer solution structure in the dope. All four triblocks displayed solution scattering patterns consistent with a body-centered cubic morphology. After membrane formation, structures were characterized using a combination of scanning electron microscopy and filtration performance tests. Membrane pore densities that ranged from 4.53 × 1014 to 1.48 × 1015 pores/m 2 were observed, which are the highest pore densities yet reported for membranes using self-assembly and non-solvent induced phase separation. Hydraulic permeabilities ranging from 24 to 850 L m-2 h-1 bar-1 and pore diameters ranging from 7 to 36 nm were determined from permeation and rejection experiments. Both the hydraulic permeability and pore size increased with increasing molar mass of the parent terpolymer. The combination of polymer characterization and membrane transport tests described here demonstrates the ability to rationally design macromolecular structures to target specific performance characteristics in block copolymer derived ultrafiltration membranes. © 2013 Elsevier Ltd. All rights reserved.

  12. Design of the fill/transfer station cryostat for the OMEGA cryogenic target system

    International Nuclear Information System (INIS)

    Gibson, C.R.; Charmin, C.M.; Del Bene, J.V.; Hoffmann, E.H.; Besenbruch, G.E.; Anteby, I.

    1997-09-01

    General Atomics is designing, testing and fabricating a system for supplying cryogenic targets for the University of Rochester's OMEGA laser system. A prototype system has demonstrated the filling of 1 mm diameter, 3 microm wall plastic spheres to 111 MPa (1,100 atm) with deuterium and then cooling to 18 K to condense the fuel. The production design must be capable of routinely filling and cooling targets with a 50/50 mix of deuterium and tritium and transferring them to a device which places the targets into the focus of 60 laser beams. This paper discusses the design and analysis of the production Fill/Transfer Station cryostat. The cryostat has two major components, a fixed base and a removable dome. The joint between the base and the dome is similar to a bayonet fitting and is sealed by a room temperature elastomeric o-ring. Since the cryostat must be housed in a glovebox, its design is driven strongly by maintenance requirements. To reach the equipment inside the cryostat, the dome is simply unbolted and lifted. The inside of the cryostat is maintained at 16 K by a closed loop helium flow system. Gaseous helium at about 1.4 MPa (200 psi) flows through tubes which are brazed to the inner walls. Cooling is provided by several cryocoolers which are located external to the cryostat. Liquid nitrogen is used as a heat intercept and to precool the helium gas

  13. The effect of requirements prioritization on avionics system conceptual design

    Science.gov (United States)

    Lorentz, John

    This dissertation will provide a detailed approach and analysis of a new collaborative requirements prioritization methodology that has been used successfully on four Coast Guard avionics acquisition and development programs valued at $400M+. A statistical representation of participant study results will be discussed and analyzed in detail. Many technically compliant projects fail to deliver levels of performance and capability that the customer desires. Some of these systems completely meet "threshold" levels of performance; however, the distribution of resources in the process devoted to the development and management of the requirements does not always represent the voice of the customer. This is especially true for technically complex projects such as modern avionics systems. A simplified facilitated process for prioritization of system requirements will be described. The collaborative prioritization process, and resulting artifacts, aids the systems engineer during early conceptual design. All requirements are not the same in terms of customer priority. While there is a tendency to have many thresholds inside of a system design, there is usually a subset of requirements and system performance that is of the utmost importance to the design. These critical capabilities and critical levels of performance typically represent the reason the system is being built. The systems engineer needs processes to identify these critical capabilities, the associated desired levels of performance, and the risks associated with the specific requirements that define the critical capability. The facilitated prioritization exercise is designed to collaboratively draw out these critical capabilities and levels of performance so they can be emphasized in system design. Developing the purpose, scheduling and process for prioritization events are key elements of systems engineering and modern project management. The benefits of early collaborative prioritization flow throughout the

  14. Optimum design of beam window's diameter and thickness of Hyper target system

    International Nuclear Information System (INIS)

    Cho, C. H.; Tak, N. I.; Song, T. Y.; Park, W. S.

    2002-01-01

    HYPER is designed to transmute long-lived TRU and fission products such as Tc-99 and I-129. Pb-Bi is used as the coolant and spallation target material at the same time. HYPER is expected to need about 20mA proton beam to sustain a 1000MW th power level. The cylindrical beam tube and spherical window is adopted as the basic window shape of HYPER. The window diameter and the window thickness are varied to find the maximum allowable current based on the design criteria : Pb-Bi temperature < 500 .deg. C, window temperature < 600 .deg. C, Pb-Bi velocity < 2m/s and window stress < 160MPa. The LAHET code is used to simulate heat generation. CFX is also used for the thermal-hydraulics calculation. Based on our design criteria, the maximum allowable current is calculated to be about 9.2mA, which is smaller than the required current. Therefore, an upgrade of the target system design is required

  15. Design of the solid target structure and the study on the coolant flow distribution in the solid target using the 2-dimensional flow analysis

    International Nuclear Information System (INIS)

    Haga, Katsuhiro; Terada, Atsuhiko; Ishikura, Shuichi; Teshigawara, Makoto; Kinoshita, Hidetaka; Kobayashi, Kaoru; Kaminaga, Masaki; Hino, Ryutaro; Susuki, Akira

    1999-11-01

    A solid target cooled by heavy water is presently under development under the Neutron Science Research Project of the Japan Atomic Energy Research Institute (JAERI). Target plates of several millimeters thickness made of heavy metal are used as the spallation target material and they are put face to face in a row with one to two millimeters gaps in between though which heavy water flows, as the coolant. Based on the design criteria regarding the target plate cooling, the volume percentage of the coolant, and the thermal stress produced in the target plates, we conducted thermal and hydraulic analysis with a one dimensional target plate model. We choosed tungsten as the target material, and decided on various target plate thicknesses. We then calculated the temperature and the thermal stress in the target plates using a two dimensional model, and confirmed the validity of the target plate thicknesses. Based on these analytical results, we proposed a target structure in which forty target plates are divided into six groups and each group is cooled using a single pass of coolant. In order to investigate the relationship between the distribution of the coolant flow, the pressure drop, and the coolant velocity, we conducted a hydraulic analysis using the general purpose hydraulic analysis code. As a result, we realized that an uniform coolant flow distribution can be achieved under a wide range of flow velocity conditions in the target plate cooling channels from 1 m/s to 10 m/s. The pressure drop along the coolant path was 0.09 MPa and 0.17 MPa when the coolant flow velocity was 5 m/s and 7 m/s respectively, which is required to cool the 1.5 MW and 2.5 MW solid targets. (author)

  16. Codes, standards, and requirements for DOE facilities: natural phenomena design

    International Nuclear Information System (INIS)

    Webb, A.B.

    1985-01-01

    The basic requirements for codes, standards, and requirements are found in DOE Orders 5480.1A, 5480.4, and 6430.1. The type of DOE facility to be built and the hazards which it presents will determine the criteria to be applied for natural phenomena design. Mandatory criteria are established in the DOE orders for certain designs but more often recommended guidance is given. National codes and standards form a great body of experience from which the project engineer may draw. Examples of three kinds of facilities and the applicable codes and standards are discussed. The safety program planning approach to project management used at Westinghouse Hanford is outlined. 5 figures, 2 tables

  17. Drosophila photoreceptor axon guidance and targeting requires the dreadlocks SH2/SH3 adapter protein.

    Science.gov (United States)

    Garrity, P A; Rao, Y; Salecker, I; McGlade, J; Pawson, T; Zipursky, S L

    1996-05-31

    Mutations in the Drosophila gene dreadlocks (dock) disrupt photoreceptor cell (R cell) axon guidance and targeting. Genetic mosaic analysis and cell-type-specific expression of dock transgenes demonstrate dock is required in R cells for proper innervation. Dock protein contains one SH2 and three SH3 domains, implicating it in tyrosine kinase signaling, and is highly related to the human proto-oncogene Nck. Dock expression is detected in R cell growth cones in the target region. We propose Dock transmits signals in the growth cone in response to guidance and targeting cues. These findings provide an important step for dissection of signaling pathways regulating growth cone motility.

  18. Uncertainty reduction requirements in cores designed for passive reactivity shutdown

    International Nuclear Information System (INIS)

    Wade, D.C.

    1988-01-01

    The first purpose of this paper is to describe the changed focus of neutronics accuracy requirements existing in the current US advanced LMR development program where passive shutdown is a major design goal. The second purpose is to provide the background and rationale which supports the selection of a formal data fitting methodology as the means for the application of critical experiment measurements to meet these accuracy needs. 6 refs., 1 fig., 2 tabs

  19. Key Design Requirements for Long-Reach Manipulators

    Energy Technology Data Exchange (ETDEWEB)

    Kwon, D.S.

    2001-01-01

    Long-reach manipulators differ from industrial robots and teleoperators typically used in the nuclear industry in that the aspect ratio (length to diameter) of links is much greater and link flexibility, as well as joint or drive train flexibility, is likely to be significant. Long-reach manipulators will be required for a variety of applications in the Environmental Restoration and Waste Management Program. While each application will present specific functional, kinematic, and performance requirements, an approach for determining the kinematic applicability and performance characteristics is presented, with a focus on waste storage tank remediation. Requirements are identified, kinematic configurations are considered, and a parametric study of link design parameters and their effects on performance characteristics is presented.

  20. Design requirements for ubiquitous computing environments for healthcare professionals.

    Science.gov (United States)

    Bång, Magnus; Larsson, Anders; Eriksson, Henrik

    2004-01-01

    Ubiquitous computing environments can support clinical administrative routines in new ways. The aim of such computing approaches is to enhance routine physical work, thus it is important to identify specific design requirements. We studied healthcare professionals in an emergency room and developed the computer-augmented environment NOSTOS to support teamwork in that setting. NOSTOS uses digital pens and paper-based media as the primary input interface for data capture and as a means of controlling the system. NOSTOS also includes a digital desk, walk-up displays, and sensor technology that allow the system to track documents and activities in the workplace. We propose a set of requirements and discuss the value of tangible user interfaces for healthcare personnel. Our results suggest that the key requirements are flexibility in terms of system usage and seamless integration between digital and physical components. We also discuss how ubiquitous computing approaches like NOSTOS can be beneficial in the medical workplace.

  1. Key design requirements for long-reach manipulators

    International Nuclear Information System (INIS)

    Kwon, D.S.; March-Leuba, S.; Babcock, S.M.; Hamel, W.R.

    1993-09-01

    Long-reach manipulators differ from industrial robots and teleoperators typically used in the nuclear industry in that the aspect ratio (length to diameter) of links is much greater and link flexibility, as well as joint or drive train flexibility, is likely to be significant. Long-reach manipulators will be required for a variety of applications in the Environmental Restoration and Waste Management Program. While each application will present specific functional kinematic, and performance requirements an approach for determining the kinematic applicability and performance characteristics is presented, with a focus on waste storage tank remediation. Requirements are identified, kinematic configurations are considered, and a parametric study of link design parameters and their effects on performance characteristics is presented

  2. Key Design Requirements for Long-Reach Manipulators

    International Nuclear Information System (INIS)

    Kwon, D.S.

    2001-01-01

    Long-reach manipulators differ from industrial robots and teleoperators typically used in the nuclear industry in that the aspect ratio (length to diameter) of links is much greater and link flexibility, as well as joint or drive train flexibility, is likely to be significant. Long-reach manipulators will be required for a variety of applications in the Environmental Restoration and Waste Management Program. While each application will present specific functional, kinematic, and performance requirements, an approach for determining the kinematic applicability and performance characteristics is presented, with a focus on waste storage tank remediation. Requirements are identified, kinematic configurations are considered, and a parametric study of link design parameters and their effects on performance characteristics is presented

  3. Design Requirements of an Advanced HANARO Reactor Core Cooling System

    International Nuclear Information System (INIS)

    Park, Yong Chul; Ryu, Jeong Soo

    2007-12-01

    An advanced HANARO Reactor (AHR) is an open-tank-type and generates thermal power of 20 MW and is under conceptual design phase for developing it. The thermal power is including a core fission heat, a temporary stored fuel heat in the pool, a pump heat and a neutron reflecting heat in the reflector vessel of the reactor. In order to remove the heat load, the reactor core cooling system is composed of a primary cooling system, a primary cooling water purification system and a reflector cooling system. The primary cooling system must remove the heat load including the core fission heat, the temporary stored fuel heat in the pool and the pump heat. The purification system must maintain the quality of the primary cooling water. And the reflector cooling system must remove the neutron reflecting heat in the reflector vessel of the reactor and maintain the quality of the reflector. In this study, the design requirement of each system has been carried out using a design methodology of the HANARO within a permissible range of safety. And those requirements are written by english intend to use design data for exporting the research reactor

  4. Evolution of general design requirements for french pressurized water reactors

    International Nuclear Information System (INIS)

    Gros, G.; Jalouneix, J.; Rollinger, F.

    1988-10-01

    The design of French pressurized water reactors is based first on deterministic principles, using the well-known defense in depth concept. This safety approach, basically reflected current American practice at that time, which consisted notably in designing engineered safeguard systems capable of limiting the consequences of accidents assumed to be credible despite the preventive measures taken. Further reflections have led to complete this approach, resulting in modifications to regulatory practice, mainly related to better practical assimilation of the problems arising during plant unit operation and reactor control after an accident and to the determination to enhance the overall consistency of the safety approach. As regards system redundancy, it should be noted that common cause failures can result in the total loss of a redundant system. System redundancy aspects will be dealt with in Chapter 2. As regards study of design basis accidents, attention was focused on the human intervention stage following automatic activation of protection and safeguard systems. This resulted, for all plant units, in the revision of operating procedures, accompanied by examination of the means required for their implementation. These subjects will be discussed in Chapter 3. Finally, as regards equipment classification, the range of equipment subjected to particular requirements, formerly limited to design basis safety classified equipment, was enlarged to include important for safety equipment. This subject will be dealt with in Chapter 5

  5. Maximizing in vivo target clearance by design of pH-dependent target binding antibodies with altered affinity to FcRn.

    Science.gov (United States)

    Yang, Danlin; Giragossian, Craig; Castellano, Steven; Lasaro, Marcio; Xiao, Haiguang; Saraf, Himanshu; Hess Kenny, Cynthia; Rybina, Irina; Huang, Zhong-Fu; Ahlberg, Jennifer; Bigwarfe, Tammy; Myzithras, Maria; Waltz, Erica; Roberts, Simon; Kroe-Barrett, Rachel; Singh, Sanjaya

    2017-10-01

    Antibodies with pH-dependent binding to both target antigens and neonatal Fc receptor (FcRn) provide an alternative tool to conventional neutralizing antibodies, particularly for therapies where reduction in antigen level is challenging due to high target burden. However, the requirements for optimal binding kinetic framework and extent of pH dependence for these antibodies to maximize target clearance from circulation are not well understood. We have identified a series of naturally-occurring high affinity antibodies with pH-dependent target binding properties. By in vivo studies in cynomolgus monkeys, we show that pH-dependent binding to the target alone is not sufficient for effective target removal from circulation, but requires Fc mutations that increase antibody binding to FcRn. Affinity-enhanced pH-dependent FcRn binding that is double-digit nM at pH 7.4 and single-digit nM at pH 6 achieved maximal target reduction when combined with similar target binding affinities in reverse pH directions. Sustained target clearance below the baseline level was achieved 3 weeks after single-dose administration at 1.5 mg/kg. Using the experimentally derived mechanistic model, we demonstrate the essential kinetic interplay between target turnover and antibody pH-dependent binding during the FcRn recycling, and identify the key components for achieving maximal target clearance. These results bridge the demand for improved patient dosing convenience with the "know-how" of therapeutic modality by design.

  6. Conceptual design studies for the liquid metal target META:LIC

    International Nuclear Information System (INIS)

    Class, A.G.; Fazio, C.; Fetzer, J.R.; Gordeev, S.

    2014-01-01

    When the construction of ESS (European Spallation Source) in Sweden was initiated, the target station concept selection group decided to reevaluate a variety of target designs to respect new developments in their selection process. The META:LIC (MEgawatt TArget:Lead bIsmuth Cooled) target concept was developed following an extensive analysis of existing and new proposed designs and reached the level of proof of principle within only 2 years. ESS selected META:LIC as comparative target option for licensing purposes during the design update phase of ESS. The present work describes the design motivation of META:LIC referring to properties and design features of other targets. Therefore, META:LIC design is an evolutionary target which incorporates the extensive experience of liquid metal targets. The modular LBE (Lead Bismuth Eutectic) target concept with focus on the target module is introduced. Both, a window target option for the start of operation and a windowless option with extended lifetime are foreseen. Thermohydraulic simulations show that adequate window cooling can be realized. The stability of the free surface in the windowless option has been shown. Robust target module instrumentation based on free surface levels and the MEGAPIE experience is proposed for target control. Since the META:LIC concept foresees a horizontal extraction for both moderators and target from the monolith a safety concept based on the SNS and JSNS experience is proposed

  7. Criteria for selection of target materials and design of high-efficiency-release targets for radioactive ion beam generation

    CERN Document Server

    Alton, G D; Liu, Y

    1999-01-01

    In this report, we define criteria for choosing target materials and for designing, mechanically stable, short-diffusion-length, highly permeable targets for generation of high-intensity radioactive ion beams (RIBs) for use at nuclear physics and astrophysics research facilities based on the ISOL principle. In addition, lists of refractory target materials are provided and examples are given of a number of successful targets, based on these criteria, that have been fabricated and tested for use at the Holifield Radioactive Ion Beam Facility (HRIBF).

  8. Design requirements and performance requirements for reactor fuel recycle manipulator systems

    International Nuclear Information System (INIS)

    Grundmann, J.G.

    1975-01-01

    The development of a new generation of remote handling devices for remote production work in support of reactor fuel recycle systems is discussed. These devices require greater mobility, speed and visual capability than remote handling systems used in research activities. An upgraded manipulator system proposed for a High-Temperature Gas-Cooled Reactor fuel refabrication facility is described. Design and performance criteria for the manipulators, cranes, and TV cameras in the proposed system are enumerated

  9. Design requirements, operation and maintenance of gas-cooled reactors

    International Nuclear Information System (INIS)

    1989-06-01

    At the invitation of the Government of the USA the Technical Committee Meeting on Design Requirements, Operation and Maintenance of Gas-Cooled Reactors, was held in San Diego on September 21-23, 1988, in tandem with the GCRA Conference. Both meetings attracted a large contingent of foreign participants. Approximately 100 delegates from 18 different countries participated in the Technical Committee meeting. The meeting was divided into three sessions: Gas-cooled reactor user requirement (8 papers); Gas-cooled reactor improvements to facilitate operation and maintenance (10 papers) and Safety, environmental impacts and waste disposal (5 papers). A separate abstract was prepared for each of these 23 papers. Refs, figs and tabs

  10. Test design requirements: Canister-scale heater test

    International Nuclear Information System (INIS)

    Schauer, M.I.; Craig, P.A.; Stickney, R.G.

    1986-03-01

    This document establishes the Test Design Requirements for the design of a canister scale heater test to be performed in the Exploratory Shaft test facility. The purpose of the test is to obtain thermomechanical rock mass response data for use in validation of the numerical models. The canister scale heater test is a full scale simulation of a high-level nuclear waste container in a prototypic emplacement borehole. Electric heaters are used to simulate the heat loads expected in an actual waste container. This document presents an overview of the test including objectives and justification for the test. A description of the test as it is presently envisioned is included. Discussions on Quality Assurance and Safety are also included in the document. 12 refs., 1 fig

  11. Electrical design requirements for electrode boilers for nuclear plants

    International Nuclear Information System (INIS)

    Kempker, M.J.

    1979-01-01

    Medium-voltage steam electrode boilers, in the 20- to 50-MW range, have become an attractive alternative to comparable fossil-fueled boilers as a source of auxiliary steam during the startup and normal shutdown of nuclear power plants. The electrode boiler represents a favorable option because of environmental, fire protection, and licensing considerations. However, this electrical option brings some difficult design problems for which solutions are required in order to integrate the electrode boiler into the plant low resistance grounded power system. These considerations include the effects of an unbalanced electrode boiler on the performance of polyphase induction motors, boiler grounding for personnel safety, boiler neutral grounding, and ground relaying

  12. Acoustic design of open plan schools and comparison of requirements

    DEFF Research Database (Denmark)

    Møller Petersen, Claus; Rasmussen, Birgit

    2012-01-01

    between groups and satisfac¬tory speech intelligibility internally in groups. This paper describes the newest Danish requirements and recommendations for such open plan areas and presents the design, measurements and subjective evaluation of two newer Danish schools. According to the users, the general...... conditions at both schools are satisfactory due to both optimized acoustical conditions and teaching methods adapted to the special open environment. The results from room acoustical modelling, verification measurements and questionnaire survey are presented and evaluated in relation to the newest Danish...

  13. Defining DSL design principles for enhancing the requirements elicitation process

    Directory of Open Access Journals (Sweden)

    Gustavo Arroyo

    2012-03-01

    Full Text Available La Elicitación de Requisitos propicia el entendimiento de las necesidades de los usuarios con respecto a un desarrollo de software. Los métodos que se emplean provienen de las ciencias sociales por lo que se carece de una retroalimentación ejecutable. Consecuentemente, la primera versión del software podría no cumplir con las expectativas. El uso de DSLs como herramientas para el descubrimiento de requisitos es una idea aceptada, desafortunadamente, muy pocos trabajos en la literatura se enfocan en la definición de principios de diseño de DSLs. En este trabajo planteamos principios de diseño de DSLs orientados a la elicitación de requisitos, enseguida, generamos casos de prueba en ANTLR, Ruby y Curry. También, enunciamos el perfil que debe tener el nuevo analista de software. Con ello, se incrementa la retroalimentación entre los involucrados en el desarrollo de software y se mejora el producto.Requirements elicitation is concerned with learning and understanding the needs of users w.r.t. a new software development. Frequently the methods employed for requirements elicitation are adapted from areas like social sciences that do not include executable (prototype based on feedback. As a consequence, it is relatively common to discover that the first release does not fit the requirements defined at the beginning of the project. Using domain-specific languages (DSLs as an auxiliary tool for requirements elicitation is a commonly well accepted idea. Unfortunately, there are few works in the literature devoted to the definition of design principles for DSLs to be experienced in the frameworks for DSL developing such as ANTLR, Ruby, and Curry. We propose design principles for the DSL development (regardless of paradigm which are sufficient to model the domain in a requirements phase. Further more we enunciate a new profile for the requirements analyst and a set of elicitation steps. The use of DSLs not only giveus an immediate feedback with

  14. Safety Design Approach for the Development of Safety Requirements for Design of Commercial HTGR

    International Nuclear Information System (INIS)

    Ohashi, Hirofumi; Sato, Hiroyuki; Nakagawa, Shigeaki; Tachibana, Yukio; Nishihara, Tetsuo; Yan, Xing; Sakaba, Nariaki; Kunitomi, Kazuhiko

    2014-01-01

    The research committee on “Safety requirements for HTGR design” was established in 2013 under the Atomic Energy Society of Japan to develop the draft safety requirements for the design of commercial High Temperature Gas-cooled Reactors (HTGRs), which incorporate the HTGR safety features demonstrated using the High Temperature Engineering Test Reactor (HTTR), lessons learned from the accident of Fukushima Daiichi Nuclear Power Station and requirements for the integration of the hydrogen production plants. The safety design approach for the commercial HTGRs which is a basement of the safety requirements is determined prior to the development of the safety requirements. The safety design approaches for the commercial HTGRs are to confine the radioactive materials within the coated fuel particles not only during normal operation but also during accident conditions, and the integrity of the coated fuel particles and other requiring physical barriers are protected by the inherent and passive safety features. This paper describes the main topics of the research committee, the safety design approaches and the safety functions of the commercial HTGRs determined in the research committee. (author)

  15. Novel target design for enhanced laser driven proton acceleration

    Directory of Open Access Journals (Sweden)

    Malay Dalui

    2017-09-01

    Full Text Available We demonstrate a simple method of preparing structured target for enhanced laser-driven proton acceleration under target-normal-sheath-acceleration scheme. A few layers of genetically modified, clinically grown micron sized E. Coli bacteria cell coated on a thin metal foil has resulted in an increase in the maximum proton energy by about 1.5 times and the total proton yield is enhanced by approximately 25 times compared to an unstructured reference foil at a laser intensity of 1019 W/cm2. Particle-in-cell simulations on the system shows that the structures on the target-foil facilitates anharmonic resonance, contributing to enhanced hot electron production which leads to stronger accelerating field. The effect is observed to grow as the number of structures is increased in the focal area of the laser pulse.

  16. Nuclear design and technical development required for ISER plant

    International Nuclear Information System (INIS)

    Yokoyama, Takashi; Yamano, Naoki.

    1987-01-01

    The report outlines some results of a study carried out by the ISER (intrinsically safe and economical reactor) Investigation Group. In particular, nuclear design concepts are examined in relation to the fuel cycle. Discussion is also made on technical development efforts to be made for realizing an ISER. Calculation of some basic nuclear design parameters is performed and results are used to examine the reactor core and fuel for ISER. As a result, it is indicated that a high-burnup type reactor core should be used on a 4.5-batch replacement, 15 EFPM (effective full power month) scheme to optimize an ISER. For technical development, consideration is made on various tests to be performed with an experimental reactor, called ISER-E, as well as other tests to provide basic data required for demonstrating the inherent safety of ISER. The study also deals with the possibility of the application of currently available light water reactor techniques to experiments with a critical assembly, non-nuclear test loop, and the experimental reactor ISER-E. It is revealed that many of the required experiments can be carried out by using test facilities and light water reactor techniques which are currently, or will be readily, available. It is stressed that international cooperation is necessary to accomplish these tests. (Nogami, K.)

  17. MEGAPIE spallation target: Design, manufacturing and preliminary tests of the first pro-typical spallation target for future ADS

    International Nuclear Information System (INIS)

    Latge, Ch.; Laffont, G.; Groeschel, F.; Thomsen, K.; Wagner, W.; Agostini, P.; Dierckx, M.; Fazio, C.; Kirchner, T.; Kurata, Y.; Song, T.; Woloshun, K.

    2006-01-01

    Partitioning and Transmutation (P and T) techniques could contribute to reduce the radioactive inventory and its associated radiotoxicity. Sub-critical Accelerator Driven Systems (ADS) are potential candidates as dedicated transmutation systems, and thus their development is a relevant R and D topic in Europe. Following a first phase focused on the understanding of the basic principles of ADS (e.g. the programme MUSE), the R and D has been streamlined and focused on practical demonstration key issues. These demonstrations cover high intensity proton accelerators (beam current in the range 1 to 20 mA), spallation targets of high power and their effective coupling with a subcritical core. Presently there is general consensus that up to 1 MW of beam power solid targets are feasible from a heat removal point of view. For higher power levels liquid metal targets are the option of choice because of their higher heat removal capability, higher spallation material density in the volume and lower specific radioactivity, Therefore, a key experiment in the ADS road map, the Megawatt Pilot Experiment (MEGAPIE) (1 MW) was initiated in 1999 in order to design and build a liquid lead-bismuth spallation target, then to operate it into the Swiss spallation neutron facility SINQ at Paul Scherrer Institute (PSI). It has to be equipped to provide the largest possible amount of scientific and technical information without jeopardizing its safe operation. The minimum design service life has been fixed at 1 year (6000 mAh). Whereas the interest of the partner institutes is driven by the development needs of ADS, PSI interest lies also in the potential use of a LM target as a SINQ standard target providing a higher neutron flux than the current solid targets. Calculations of the radial distribution of the undisturbed thermal neutron flux for the LBE target in comparison to the former Zircaloy and current steel-clad solid lead target were done with different nuclear codes; nevertheless

  18. Injector design for liner-on-target gas-puff experiments

    Science.gov (United States)

    Valenzuela, J. C.; Krasheninnikov, I.; Conti, F.; Wessel, F.; Fadeev, V.; Narkis, J.; Ross, M. P.; Rahman, H. U.; Ruskov, E.; Beg, F. N.

    2017-11-01

    We present the design of a gas-puff injector for liner-on-target experiments. The injector is composed of an annular high atomic number (e.g., Ar and Kr) gas and an on-axis plasma gun that delivers an ionized deuterium target. The annular supersonic nozzle injector has been studied using Computational Fluid Dynamics (CFD) simulations to produce a highly collimated (M > 5), ˜1 cm radius gas profile that satisfies the theoretical requirement for best performance on ˜1-MA current generators. The CFD simulations allowed us to study output density profiles as a function of the nozzle shape, gas pressure, and gas composition. We have performed line-integrated density measurements using a continuous wave (CW) He-Ne laser to characterize the liner gas density. The measurements agree well with the CFD values. We have used a simple snowplow model to study the plasma sheath acceleration in a coaxial plasma gun to help us properly design the target injector.

  19. Design Tools for Cost-Effective Implementation of Planetary Protection Requirements

    Science.gov (United States)

    Hamlin, Louise; Belz, Andrea; Evans, Michael; Kastner, Jason; Satter, Celeste; Spry, Andy

    2006-01-01

    Since the Viking missions to Mars in the 1970s, accounting for the costs associated with planetary protection implementation has not been done systematically during early project formulation phases, leading to unanticipated costs during subsequent implementation phases of flight projects. The simultaneous development of more stringent planetary protection requirements, resulting from new knowledge about the limits of life on Earth, together with current plans to conduct life-detection experiments on a number of different solar system target bodies motivates a systematic approach to integrating planetary protection requirements and mission design. A current development effort at NASA's Jet Propulsion Laboratory is aimed at integrating planetary protection requirements more fully into the early phases of mission architecture formulation and at developing tools to more rigorously predict associated cost and schedule impacts of architecture options chosen to meet planetary protection requirements.

  20. STRUCTURAL DESIGN CRITERIA FOR TARGET/BLANKET SYSTEM COMPONENT MATERIALS FOR THE ACCELERATOR PRODUCTION OF TRITIUM PROJECT

    Energy Technology Data Exchange (ETDEWEB)

    W. JOHNSON; R. RYDER; P. RITTENHOUSE

    2001-01-01

    The design of target/blanket system components for the Accelerator Production of Tritium (APT) plant is dependent on the development of materials properties data specified by the designer. These data are needed to verify that component designs are adequate. The adequacy of the data will be related to safety, performance, and economic considerations, and to other requirements that may be deemed necessary by customers and regulatory bodies. The data required may already be in existence, as in the open technical literature, or may need to be generated, as is often the case for the design of new systems operating under relatively unique conditions. The designers' starting point for design data needs is generally some form of design criteria used in conjunction with a specified set of loading conditions and associated performance requirements. Most criteria are aimed at verifying the structural adequacy of the component, and often take the form of national or international standards such as the ASME Boiler and Pressure Vessel Code (ASME B and PV Code) or the French Nuclear Structural Requirements (RCC-MR). Whether or not there are specific design data needs associated with the use of these design criteria will largely depend on the uniqueness of the conditions of operation of the component. A component designed in accordance with the ASME B and PV Code, where no unusual environmental conditions exist, will utilize well-documented, statistically-evaluated developed in conjunction with the Code, and will not be likely to have any design data needs. On the other hand, a component to be designed to operate under unique APT conditions, is likely to have significant design data needs. Such a component is also likely to require special design criteria for verification of its structural adequacy, specifically accounting for changes in materials properties which may occur during exposure in the service environment. In such a situation it is common for the design criteria

  1. Changing paradigm from one target one ligand towards multi target directed ligand design for key drug targets of Alzheimer disease: An important role of Insilco methods in multi target directed ligands design.

    Science.gov (United States)

    Kumar, Akhil; Tiwari, Ashish; Sharma, Ashok

    2018-03-15

    Alzheimer disease (AD) is now considered as a multifactorial neurodegenerative disorder and rapidly increasing to an alarming situation and causing higher death rate. One target one ligand hypothesis is not able to provide complete solution of AD due to multifactorial nature of disease and one target one drug seems to fail to provide better treatment against AD. Moreover, current available treatments are limited and most of the upcoming treatments under clinical trials are based on modulating single target. So the current AD drug discovery research shifting towards new approach for better solution that simultaneously modulate more than one targets in the neurodegenerative cascade. This can be achieved by network pharmacology, multi-modal therapies, multifaceted, and/or the more recently proposed term "multi-targeted designed drugs. Drug discovery project is tedious, costly and long term project. Moreover, multi target AD drug discovery added extra challenges such as good binding affinity of ligands for multiple targets, optimal ADME/T properties, no/less off target side effect and crossing of the blood brain barrier. These hurdles may be addressed by insilico methods for efficient solution in less time and cost as computational methods successfully applied to single target drug discovery project. Here we are summarizing some of the most prominent and computationally explored single target against AD and further we discussed successful example of dual or multiple inhibitors for same targets. Moreover we focused on ligand and structure based computational approach to design MTDL against AD. However is not an easy task to balance dual activity in a single molecule but computational approach such as virtual screening docking, QSAR, simulation and free energy are useful in future MTDLs drug discovery alone or in combination with fragment based method. However, rational and logical implementations of computational drug designing methods are capable of assisting AD drug

  2. Requirements and Design Guidelines for a Trusted Hypervisor Interface

    Science.gov (United States)

    Weber, Dirk; Weber, Arnd; Presti, Stéphane Lo

    Hypervisor technology in combination with tamper-resistant hardware such as Trusted Platform Modules has the potential of providing a significant new level of security for computers. These new systems will be able to protect legacy applications from applications such as malware, and they will enable the creation of new secure applications. This paper analyses the requirements for the graphical user interface (GUI) of such a system. First, application scenarios are presented to illustrate how extended Trusted Computing (TC) systems might be used in the future. Requirements for a trusted GUI are then derived from the analysis of articles on TC found in the media and from a survey of experts in information technology. These requirements are compared to existing proposals, showing how some of them are either inconvenient or insecure in the hands of end users. Based on this analysis, proposals are derived for the design of a trusted GUI suitable for laypersons and administrators, which uses familiar patterns, and yet protects against visual mimicry attacks. These proposals pave the way for hypervisors’ security-enhanced GUI.

  3. Design and Implementation of the Automated Rendezvous Targeting Algorithms for Orion

    Science.gov (United States)

    DSouza, Christopher; Weeks, Michael

    2010-01-01

    The Orion vehicle will be designed to perform several rendezvous missions: rendezvous with the ISS in Low Earth Orbit (LEO), rendezvous with the EDS/Altair in LEO, a contingency rendezvous with the ascent stage of the Altair in Low Lunar Orbit (LLO) and a contingency rendezvous in LLO with the ascent and descent stage in the case of an aborted lunar landing. Therefore, it is not difficult to realize that each of these scenarios imposes different operational, timing, and performance constraints on the GNC system. To this end, a suite of on-board guidance and targeting algorithms have been designed to meet the requirement to perform the rendezvous independent of communications with the ground. This capability is particularly relevant for the lunar missions, some of which may occur on the far side of the moon. This paper will describe these algorithms which are designed to be structured and arranged in such a way so as to be flexible and able to safely perform a wide variety of rendezvous trajectories. The goal of the algorithms is not to merely fly one specific type of canned rendezvous profile. Conversely, it was designed from the start to be general enough such that any type of trajectory profile can be flown.(i.e. a coelliptic profile, a stable orbit rendezvous profile, and a expedited LLO rendezvous profile, etc) all using the same rendezvous suite of algorithms. Each of these profiles makes use of maneuver types which have been designed with dual goals of robustness and performance. They are designed to converge quickly under dispersed conditions and they are designed to perform many of the functions performed on the ground today. The targeting algorithms consist of a phasing maneuver (NC), an altitude adjust maneuver (NH), and plane change maneuver (NPC), a coelliptic maneuver (NSR), a Lambert targeted maneuver, and several multiple-burn targeted maneuvers which combine one of more of these algorithms. The derivation and implementation of each of these

  4. Membrane Transporters: Structure, Function and Targets for Drug Design

    Science.gov (United States)

    Ravna, Aina W.; Sager, Georg; Dahl, Svein G.; Sylte, Ingebrigt

    Current therapeutic drugs act on four main types of molecular targets: enzymes, receptors, ion channels and transporters, among which a major part (60-70%) are membrane proteins. This review discusses the molecular structures and potential impact of membrane transporter proteins on new drug discovery. The three-dimensional (3D) molecular structure of a protein contains information about the active site and possible ligand binding, and about evolutionary relationships within the protein family. Transporters have a recognition site for a particular substrate, which may be used as a target for drugs inhibiting the transporter or acting as a false substrate. Three groups of transporters have particular interest as drug targets: the major facilitator superfamily, which includes almost 4000 different proteins transporting sugars, polyols, drugs, neurotransmitters, metabolites, amino acids, peptides, organic and inorganic anions and many other substrates; the ATP-binding cassette superfamily, which plays an important role in multidrug resistance in cancer chemotherapy; and the neurotransmitter:sodium symporter family, which includes the molecular targets for some of the most widely used psychotropic drugs. Recent technical advances have increased the number of known 3D structures of membrane transporters, and demonstrated that they form a divergent group of proteins with large conformational flexibility which facilitates transport of the substrate.

  5. Model-Based Requirements Management in Gear Systems Design Based On Graph-Based Design Languages

    Directory of Open Access Journals (Sweden)

    Kevin Holder

    2017-10-01

    Full Text Available For several decades, a wide-spread consensus concerning the enormous importance of an in-depth clarification of the specifications of a product has been observed. A weak clarification of specifications is repeatedly listed as a main cause for the failure of product development projects. Requirements, which can be defined as the purpose, goals, constraints, and criteria associated with a product development project, play a central role in the clarification of specifications. The collection of activities which ensure that requirements are identified, documented, maintained, communicated, and traced throughout the life cycle of a system, product, or service can be referred to as “requirements engineering”. These activities can be supported by a collection and combination of strategies, methods, and tools which are appropriate for the clarification of specifications. Numerous publications describe the strategy and the components of requirements management. Furthermore, recent research investigates its industrial application. Simultaneously, promising developments of graph-based design languages for a holistic digital representation of the product life cycle are presented. Current developments realize graph-based languages by the diagrams of the Unified Modelling Language (UML, and allow the automatic generation and evaluation of multiple product variants. The research presented in this paper seeks to present a method in order to combine the advantages of a conscious requirements management process and graph-based design languages. Consequently, the main objective of this paper is the investigation of a model-based integration of requirements in a product development process by means of graph-based design languages. The research method is based on an in-depth analysis of an exemplary industrial product development, a gear system for so-called “Electrical Multiple Units” (EMU. Important requirements were abstracted from a gear system

  6. Backward Design: Targeting Depth of Understanding for All Learners

    Science.gov (United States)

    Childre, Amy; Sands, Jennifer R.; Pope, Saundra Tanner

    2009-01-01

    Curriculum design is at the center of developing student ability to construct understanding. Without appropriately designed curriculum, instruction can be ineffective at scaffolding understanding. Often students with disabilities need more explicit instruction or guidance in applying their schema to new information. Thus, instruction must not only…

  7. Mechanical design of experimental apparatus for FIREX cryo-target cooling

    Science.gov (United States)

    Iwamoto, A.; Norimatsu, T.; Nakai, M.; Sakagami, H.; Fujioka, S.; Shiraga, H.; Azechi, H.

    2016-05-01

    Mechanical design of an experimental apparatus for FIREX cryo-target cooling is described. Gaseous helium (GHe) sealing system at a cryogenic environment is an important issue for laser fusion experiments. The dedicated loading system was designed for a metal gasket. We take U-TIGHTSEAL® (Usui Kokusai Sangyo Kaisha. Ltd.) with an indium plated copper jacket as an example. According to its specification, a linear load of 110 N/m along its circumference is the optimum compression; however a lower load would still maintain helium (He) leak below the required level. Its sealing performance was investigated systematically. Our system demanded 27 N/mm of the load to keep He leak tightness in a cryogenic environment. Once leak tightness was obtained, it could be reduced to 9.5 N/mm.

  8. Satellite Ocean Color Sensor Design Concepts and Performance Requirements

    Science.gov (United States)

    McClain, Charles R.; Meister, Gerhard; Monosmith, Bryan

    2014-01-01

    800 nanometers with three additional discrete near infrared (NIR) and shortwave infrared (SWIR) ocean aerosol correction bands. Also, to avoid drift in sensor sensitivity from being interpreted as environmental change, climate change research requires rigorous monitoring of sensor stability. For SeaWiFS, monthly lunar imaging accurately tracked stability at an accuracy of approximately 0.1% that allowed the data to be used for climate studies [2]. It is now acknowledged by the international community that future missions and sensor designs need to accommodate lunar calibrations. An overview of ocean color remote sensing and a review of the progress made in ocean color remote sensing and the variety of research applications derived from global satellite ocean color data are provided. The purpose of this chapter is to discuss the design options for ocean color satellite radiometers, performance and testing criteria, and sensor components (optics, detectors, electronics, etc.) that must be integrated into an instrument concept. These ultimately dictate the quality and quantity of data that can be delivered as a trade against mission cost. Historically, science and sensor technology have advanced in a "leap-frog" manner in that sensor design requirements for a mission are defined many years before a sensor is launched and by the end of the mission, perhaps 15-20 years later, science applications and requirements are well beyond the capabilities of the sensor. Section 3 provides a summary of historical mission science objectives and sensor requirements. This progression is expected to continue in the future as long as sensor costs can be constrained to affordable levels and still allow the incorporation of new technologies without incurring unacceptable risk to mission success. The IOCCG Report Number 13 discusses future ocean biology mission Level-1 requirements in depth.

  9. 1L Mark-IV Target Design Review

    Energy Technology Data Exchange (ETDEWEB)

    Koehler, Paul E. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-11-16

    This presentation includes General Design Considerations; Current (Mark-III) Lower Tier; Mark-III Upper Tier; Performance Metrics; General Improvements for Material Science; General Improvements for Nuclear Science; Improving FOM for Nuclear Science; General Design Considerations Summary; Design Optimization Studies; Expected Mark-IV Performance: Material Science; Expected Mark-IV Performance: Nuclear Science (Disk); Mark IV Enables Much Wider Range of Nuclear-Science FOM Gains than Mark III; Mark-IV Performance Summary; Rod or Disk? Center or Real FOV?; and Project Cost and Schedule.

  10. Design of a cone target for fast ignition

    Directory of Open Access Journals (Sweden)

    Sunahara Atsushi

    2013-11-01

    Full Text Available We propose a new type of target for the fast ignition of inertial confinement fusion. Pre-formed plasma inside a cone target can significantly reduce the energy coupling efficiency from the ultra-high intense short-pulse laser to the imploded core plasma. Also, in order to protect the tip of the cone and reduce generation of pre-formed plasma, we propose pointed shaped cone target. In our estimation, the shock traveling time can be delayed 20–30 ps by lower-Z material with larger areal density compared to the conventional gold flat tip. Also, the jet flow can sweep the blow-off plasma from the tip of the cone, and the implosion performance is not drastically affected by the existence of pointed tip. In addition, the self-generated magnetic field is generated along the boundary of cone tip and surrounding CD or DT plasma. This magnetic field can confine fast electrons and focus to the implosion core plasma. Resultant heating efficiency is improved by 30% compared to that with conventional gold flat tip.

  11. Global climate targets and future consumption level: an evaluation of the required GHG intensity

    International Nuclear Information System (INIS)

    Girod, Bastien; Van Vuuren, Detlef Peter; Hertwich, Edgar G

    2013-01-01

    Discussion and analysis on international climate policy often focuses on the rather abstract level of total national and regional greenhouse gas (GHG) emissions. At some point, however, emission reductions need to be translated to consumption level. In this article, we evaluate the implications of the strictest IPCC representative concentration pathway for key consumption categories (food, travel, shelter, goods, services). We use IPAT style identities to account for possible growth in global consumption levels and indicate the required change in GHG emission intensity for each category (i.e. GHG emission per calorie, person kilometer, square meter, kilogram, US dollar). The proposed concept provides guidance for product developers, consumers and policymakers. To reach the 2 °C climate target (2.1 tCO 2 -eq. per capita in 2050), the GHG emission intensity of consumption has to be reduced by a factor of 5 in 2050. The climate targets on consumption level allow discussion of the feasibility of this climate target at product and consumption level. In most consumption categories products in line with this climate target are available. For animal food and air travel, reaching the GHG intensity targets with product modifications alone will be challenging and therefore structural changes in consumption patterns might be needed. The concept opens up possibilities for further research on potential solutions on the consumption and product level to global climate mitigation. (letter)

  12. Targeting Aurora B to the equatorial cortex by MKlp2 is required for cytokinesis.

    Directory of Open Access Journals (Sweden)

    Mayumi Kitagawa

    Full Text Available Although Aurora B is important in cleavage furrow ingression and completion during cytokinesis, the mechanism by which kinase activity is targeted to the cleavage furrow and the molecule(s responsible for this process have remained elusive. Here, we demonstrate that an essential mitotic kinesin MKlp2 requires myosin-II for its localization to the equatorial cortex, and this event is required to recruit Aurora B to the equatorial cortex in mammalian cells. This recruitment event is also required to promote the highly focused accumulation of active RhoA at the equatorial cortex and stable ingression of the cleavage furrow in bipolar cytokinesis. Specifically, in drug-induced monopolar cytokinesis, targeting Aurora B to the cell cortex by MKlp2 is essential for cell polarization and furrow formation. Once the furrow has formed, MKlp2 further recruits Aurora B to the growing furrow. This process together with continuous Aurora B kinase activity at the growing furrow is essential for stable furrow propagation and completion. In contrast, a MKlp2 mutant defective in binding myosin-II does not recruit Aurora B to the cell cortex and does not promote furrow formation during monopolar cytokinesis. This mutant is also defective in maintaining the ingressing furrow during bipolar cytokinesis. Together, these findings reveal that targeting Aurora B to the cell cortex (or the equatorial cortex by MKlp2 is essential for the maintenance of the ingressing furrow for successful cytokinesis.

  13. Colocated MIMO Radar: Beamforming, Waveform design, and Target Parameter Estimation

    KAUST Repository

    Jardak, Seifallah

    2014-01-01

    outperformed the phased array radar by providing better parametric identifiability, achieving higher spatial resolution, and designing complex beampatterns. To avoid jamming and enhance the signal to noise ratio, it is often interesting to maximize

  14. Requirements and design concept for a facility mapping system

    International Nuclear Information System (INIS)

    Barry, R.E.; Burks, B.L.; Little, C.Q.

    1995-01-01

    The Department of Energy (DOE) has for some time been considering the Decontamination and Dismantlement (D ampersand D) of facilities which are no longer in use, but which are highly contaminated with radioactive wastes. One of the holdups in performing the D ampersand D task is the accumulation of accurate facility characterizations that can enable a safe and orderly cleanup process. According to the Technical Strategic Plan for the Decontamination and Decommissioning Integrated Demonstration, open-quotes the cost of characterization using current baseline technologies for approximately 100 acres of gaseous diffusion plant at Oak Ridge alone is, for the most part incalculableclose quotes. Automated, robotic techniques will be necessary for initial characterization and continued surveillance of these types of sites. Robotic systems are being designed and constructed to accomplish these tasks. This paper describes requirements and design concepts for a system to accurately map a facility contaminated with hazardous wastes. Some of the technologies involved in the Facility Mapping System are: remote characterization with teleoperated, sensor-based systems, fusion of data sets from multiple characterization systems, and object recognition from 3D data models. This Facility Mapping System is being assembled by Oak Ridge National Laboratory for the DOE Office of Technology Development Robotics Technology Development Program

  15. Defilade, Stationary Target and Moving Target Embankment, Low Water Crossing, and Course Road Designs for Soil Loss Prevention

    National Research Council Canada - National Science Library

    Svendsen, Niels G; Kalita, Prasanta K; Gebhart, Dick L; Denight, Michael L

    2006-01-01

    ... for military training requirements. This report proposes several new range structure designs to begin the iterative process of developing new range edifices that reduce soil loss, control erosion, promote sustainability, and enhance training...

  16. TRPV1: A Target for Rational Drug Design

    Directory of Open Access Journals (Sweden)

    Vincenzo Carnevale

    2016-08-01

    Full Text Available Transient Receptor Potential Vanilloid 1 (TRPV1 is a non-selective, Ca2+ permeable cation channel activated by noxious heat, and chemical ligands, such as capsaicin and resiniferatoxin (RTX. Many compounds have been developed that either activate or inhibit TRPV1, but none of them are in routine clinical practice. This review will discuss the rationale for antagonists and agonists of TRPV1 for pain relief and other conditions, and strategies to develop new, better drugs to target this ion channel, using the newly available high-resolution structures.

  17. Flat cladding and pellets in the design of an irradiation target

    International Nuclear Information System (INIS)

    Yorio, Daniel; Denis, Alicia C.; Soba, Alejandro; Beuter, Oscar; Marajofsky, Adolfo

    2003-01-01

    The design of an enriched uranium irradiation target made of flat pellets and cladding is proposed in order to improve the fission Mo 99 production. The variation range of each one of the parameters is studied and the basic design of the target is given

  18. High gain direct drive target designs and supporting experiments with KrF

    International Nuclear Information System (INIS)

    Karasik, Max; Bates, Jason W.; Aglitskiy, Yefim

    2013-01-01

    Krypton-fluoride laser is an attractive inertial fusion energy driver from the standpoint of target physics. Target designs taking advantage of zooming, shock ignition, and favorable physics with KrF reach energy gains of 200 with sub-MJ laser energy. The designs are robust under 2D simulations. Experiments on the Nike KrF laser support the physics basis. (author)

  19. Design and verification experiments for the windowless spallation target of the ADS prototype Myrrha

    International Nuclear Information System (INIS)

    Kantrien Van, Tichelen; Kupschus, P.; Arien, B.; Ait Abderrahim, H.

    2003-01-01

    SCKxCEN, the Belgian Nuclear Research Centre, works on the conceptual design and basic engineering of a multipurpose ADS for R and D, dubbed MYRRHA, a small high-performance irradiation facility with fast neutron fluxes up to 1.10 15 n/cm 2 /s to start operation in about 2010. Specific to the MYRRHA ADS system is the choice for a windowless spallation target at the centre of the subcritical core. Apart from the space limitations and material property short-comings, the current and power density figures would make the design of a solid window for the spallation source next to impossible: the chosen 5 mA at the relative low energy of 350 MeV leads to a current density of order 150 μA/cm 2 (as far as we know at least a factor of 3 higher than any window design that has been attempted to meet). This is the main reason for adopting the windowless design for MYRRHA which has as a consequence that the free surface ultimately has to be compatible with the vacuum requirements of the beam transport system of the accelerator. The total beam energy will be dumped into a volume of ca 0.5 1 leading to a heating power density of ca 3 kW/cm 3 . In order to remove this heat from the LM with an average temperature increase of 100 deg C on top of the temperature of the inlet flow of 240 deg C a total flow rate of 101/s at an average flow speed of 2.5 m/s is required. It is suggested from estimates that the evaporation from 'hot spots' with elevated temperatures beyond the average 340 deg C - close to the free surface in the re-circulation zone - is then still acceptable. The design investigations are therefore directed to assess and minimise the re-circulation zone inherent in the free surface formation under the geometry and flow requirements. This paper will summarize the design programme for the windowless design of the spallation source at the centre of the subcritical core. It will include the main findings reported in (Van Tichelen, 2000) and (Van Tichelen, 2001) and the

  20. National Ignition Facility system design requirements NIF integrated computer controls SDR004

    International Nuclear Information System (INIS)

    Bliss, E.

    1996-01-01

    This System Design Requirement document establishes the performance, design, development, and test requirements for the NIF Integrated Computer Control System. The Integrated Computer Control System (ICCS) is covered in NIF WBS element 1.5. This document responds directly to the requirements detailed in the NIF Functional Requirements/Primary Criteria, and is supported by subsystem design requirements documents for each major ICCS Subsystem

  1. Design and implementation of location-based wireless targeted advertising

    Science.gov (United States)

    Li, Benjamin; Xu, Deyin

    2001-10-01

    As advertisements are time and location sensitive, a challenge for wireless marketing is to have advertisements delivered when and where they are most convenient. In this paper we introduce a two-stage auction model for location-based wireless targeted advertising. This system extends the notion of location-based service by using location information to target advertising, and does so specifically by enabling advertisers to specify their preferences and bid for advertisement delivery, where those preferences are then used in a subsequent automated auction of actual deliveries to wireless data users. The automated auction in the second stage is especially effective because it can use information about the individual user profile data, including customer relationship management system contents as well as location from the wireless system's location management service, including potentially location history such as current trajectory from recent history and longer-term historical trip records for that user. Through two-stage auction, real-time bidding by advertisers and matching ads contents to mobile users help advertising information reach maximal value.

  2. In silico design of targeted SRM-based experiments

    Directory of Open Access Journals (Sweden)

    Nahnsen Sven

    2012-11-01

    Full Text Available Abstract Selected reaction monitoring (SRM-based proteomics approaches enable highly sensitive and reproducible assays for profiling of thousands of peptides in one experiment. The development of such assays involves the determination of retention time, detectability and fragmentation properties of peptides, followed by an optimal selection of transitions. If those properties have to be identified experimentally, the assay development becomes a time-consuming task. We introduce a computational framework for the optimal selection of transitions for a given set of proteins based on their sequence information alone or in conjunction with already existing transition databases. The presented method enables the rapid and fully automated initial development of assays for targeted proteomics. We introduce the relevant methods, report and discuss a step-wise and generic protocol and we also show that we can reach an ad hoc coverage of 80 % of the targeted proteins. The presented algorithmic procedure is implemented in the open-source software package OpenMS/TOPP.

  3. Epitope-based peptide vaccine design and target site depiction against Ebola viruses: an immunoinformatics study.

    Science.gov (United States)

    Khan, M A; Hossain, M U; Rakib-Uz-Zaman, S M; Morshed, M N

    2015-07-01

    Ebola viruses (EBOVs) have been identified as an emerging threat in recent year as it causes severe haemorrhagic fever in human. Epitope-based vaccine design for EBOVs remains a top priority because a mere progress has been made in this regard. Another reason is the lack of antiviral drug and licensed vaccine although there is a severe outbreak in Central Africa. In this study, we aimed to design an epitope-based vaccine that can trigger a significant immune response as well as to prognosticate inhibitor that can bind with potential drug target sites using various immunoinformatics and docking simulation tools. The capacity to induce both humoral and cell-mediated immunity by T cell and B cell was checked for the selected protein. The peptide region spanning 9 amino acids from 42 to 50 and the sequence TLASIGTAF were found as the most potential B and T cell epitopes, respectively. This peptide could interact with 12 HLAs and showed high population coverage up to 80.99%. Using molecular docking, the epitope was further appraised for binding against HLA molecules to verify the binding cleft interaction. In addition with this, the allergenicity of the epitopes was also evaluated. In the post-therapeutic strategy, docking study of predicted 3D structure identified suitable therapeutic inhibitor against targeted protein. However, this computational epitope-based peptide vaccine designing and target site prediction against EBOVs open up a new horizon which may be the prospective way in Ebola viruses research; the results require validation by in vitro and in vivo experiments. © 2015 John Wiley & Sons Ltd.

  4. Representing Targets of Measurement within Evidence-Centered Design

    Science.gov (United States)

    Ewing, Maureen; Packman, Sheryl; Hamen, Cynthia; Thurber, Allison Clark

    2010-01-01

    In the last few years, the Advanced Placement (AP) Program[R] has used evidence-centered assessment design (ECD) to articulate the knowledge, skills, and abilities to be taught in the course and measured on the summative exam for four science courses, three history courses, and six world language courses; its application to calculus and English…

  5. Experimental study of liquid-metal target designs of accelerating-controlled systems

    International Nuclear Information System (INIS)

    Iarmonov, Mikhail; Makhov, Kirill; Novozhilova, Olga; Meluzov, A.G.; Beznosov, A.V.

    2011-01-01

    Models of a liquid-metal target of an accelerator-controlled system have been experimentally studied at the Nizhny Novgorod State Technical University to develop an optimal design of the flow part of the target. The main explored variants of liquid-metal targets are: Design with a diaphragm (firm-and-impervious plug) mounted on the pipe tap of particle transport from the accelerator cavity to the working cavity of the liquid-metal target. Design without a diaphragm on the pipe tab of particle transport from the accelerator. The study was carried out in a high-temperature liquid-metal test bench under the conditions close to full-scale ones: the temperature of the eutectic lead-bismuth alloy was 260degC - 400degC, the coolant mass flow was 5-80 t/h, and the rarefaction in the gas cavity was 10 5 Pa, the coefficient of geometric similarity equal to 1. The experimental studies of hydrodynamic characteristics of flow parts in the designs of targets under full-scale conditions indicated high efficiency of a target in triggering, operating, and deactivating modes. Research and technology instructions for designs of the flow part of the liquid-metal target, the target design as a whole, and the target circuit of accelerator-controlled systems were formulated as a result of the studies. (author)

  6. Current therapeutic molecules and targets in neurodegenerative diseases based on in silico drug design.

    Science.gov (United States)

    Sehgal, Sheikh Arslan; Hammad, Mirza A; Tahir, Rana Adnan; Akram, Hafiza Nisha; Ahmad, Faheem

    2018-03-15

    As the number of elderly persons increases, neurodegenerative diseases are becoming ubiquitous. There is currently a great need for knowledge concerning management of old-age neurodegenerative diseases; the most important of which are: Alzheimer's disease, Parkinson's disease, Amyotrophic Lateral Sclerosis, and Huntington's disease. To summarize the potential of computationally predicted molecules and targets against neurodegenerative diseases. Review of literature published since 1997 against neurodegenerative diseases, utilizing as keywords: in silico, Alzheimer's disease, Parkinson's disease, Amyotrophic Lateral Sclerosis ALS, and Huntington's disease. Due to the costs associated with experimentation and current ethical law, performing experiments directly on living organisms has become much more difficult. In this scenario, in silico techniques have been successful and have become powerful tools in the search to cure disease. Researchers use the Computer Aided Drug Design pipeline which: 1) generates 3-dimensional structures of target proteins through homology modeling 2) achieves stabilization through molecular dynamics simulation, and 3) exploits molecular docking through large compound libraries. Next generation sequencing is continually producing enormous amounts of raw sequence data while neuroimaging is producing a multitude of raw image data. To solve such pressing problems, these new tools and algorithms are required. This review elaborates precise in silico tools and techniques for drug targets, active molecules, and molecular docking studies, together with future prospects and challenges concerning possible breakthroughs in Alzheimer's, Parkinson's, Amyotrophic Lateral Sclerosis, and Huntington's disease. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  7. Change in design targets for building energy towards smart cities

    DEFF Research Database (Denmark)

    Heller, Alfred; Gianniou, Panagiota; Katsigiannis, Emmanouil

    2014-01-01

    that there are exposed solutions where synergy effects arise that unleash extra saving potentials. Based on the insight gained by the simulations, IT intelligence and cross-component communication are to be invented to control the components and hereby to optimize the total system performance. One main strategy in doing......Designing cities from an overall energy optimization system point of view, demands changes in engineering procedures. Traditionally the design was driven independently between the involved domains and energy system components. By modelling the whole energy system in one, it is expected...... so is, to move demands from high demand periods to low demand periods and hereby to avoid “peak” demands. This is called “flexibility” within the terminology of “smart grids”. In early solutions the search was for energy capacities within the domain of the electrical grid, hence car batteries where...

  8. Designing decision support tools for targeted N-regulation

    DEFF Research Database (Denmark)

    Christensen, Andreas Aagaard; Piil, Kristoffer; Andersen, Peter Stubkjær

    2017-01-01

    data model for land use data – the dNmark landscape model. Based on input data which is corrected and edited by workshop participants, the tool estimates the effect of potential land use scenarios on nutrient emissions. The tool was tested in 5 scenario workshops in case areas in Denmark in 2016...... in Denmark to develop and improve a functioning decision support tool for landscape scale N-management. The aim of the study is to evaluate how a decision support tool can best be designed in order to enable landscape scale strategic N-management practices. Methods: A prototype GIS-tool for capturing......, storing, editing, displaying and modelling landscape scale farming practices and associated emission consequences was developed. The tool was designed to integrate locally held knowledge with national scale datasets in live scenario situations through the implementation of a flexible, uniform and editable...

  9. An optimized target-field method for MRI transverse biplanar gradient coil design

    International Nuclear Information System (INIS)

    Zhang, Rui; Xu, Jing; Huang, Kefu; Zhang, Jue; Fang, Jing; Fu, Youyi; Li, Yangjing

    2011-01-01

    Gradient coils are essential components of magnetic resonance imaging (MRI) systems. In this paper, we present an optimized target-field method for designing a transverse biplanar gradient coil with high linearity, low inductance and small resistance, which can well satisfy the requirements of permanent-magnet MRI systems. In this new method, the current density is expressed by trigonometric basis functions with unknown coefficients in polar coordinates. Following the standard procedures, we construct an objective function with respect to the total square errors of the magnetic field at all target-field points with the penalty items associated with the stored magnetic energy and the dissipated power. By adjusting the two penalty factors and minimizing the objective function, the appropriate coefficients of the current density are determined. Applying the stream function method to the current density, the specific winding patterns on the planes can be obtained. A novel biplanar gradient coil has been designed using this method to operate in a permanent-magnet MRI system. In order to verify the validity of the proposed approach, the gradient magnetic field generated by the resulted current density has been calculated via the Biot–Savart law. The results have demonstrated the effectiveness and advantage of this proposed method

  10. TARGETED SEQUENTIAL DESIGN FOR TARGETED LEARNING INFERENCE OF THE OPTIMAL TREATMENT RULE AND ITS MEAN REWARD.

    Science.gov (United States)

    Chambaz, Antoine; Zheng, Wenjing; van der Laan, Mark J

    2017-01-01

    This article studies the targeted sequential inference of an optimal treatment rule (TR) and its mean reward in the non-exceptional case, i.e. , assuming that there is no stratum of the baseline covariates where treatment is neither beneficial nor harmful, and under a companion margin assumption. Our pivotal estimator, whose definition hinges on the targeted minimum loss estimation (TMLE) principle, actually infers the mean reward under the current estimate of the optimal TR. This data-adaptive statistical parameter is worthy of interest on its own. Our main result is a central limit theorem which enables the construction of confidence intervals on both mean rewards under the current estimate of the optimal TR and under the optimal TR itself. The asymptotic variance of the estimator takes the form of the variance of an efficient influence curve at a limiting distribution, allowing to discuss the efficiency of inference. As a by product, we also derive confidence intervals on two cumulated pseudo-regrets, a key notion in the study of bandits problems. A simulation study illustrates the procedure. One of the corner-stones of the theoretical study is a new maximal inequality for martingales with respect to the uniform entropy integral.

  11. MIDAS: a practical Bayesian design for platform trials with molecularly targeted agents.

    Science.gov (United States)

    Yuan, Ying; Guo, Beibei; Munsell, Mark; Lu, Karen; Jazaeri, Amir

    2016-09-30

    Recent success of immunotherapy and other targeted therapies in cancer treatment has led to an unprecedented surge in the number of novel therapeutic agents that need to be evaluated in clinical trials. Traditional phase II clinical trial designs were developed for evaluating one candidate treatment at a time and thus not efficient for this task. We propose a Bayesian phase II platform design, the multi-candidate iterative design with adaptive selection (MIDAS), which allows investigators to continuously screen a large number of candidate agents in an efficient and seamless fashion. MIDAS consists of one control arm, which contains a standard therapy as the control, and several experimental arms, which contain the experimental agents. Patients are adaptively randomized to the control and experimental agents based on their estimated efficacy. During the trial, we adaptively drop inefficacious or overly toxic agents and 'graduate' the promising agents from the trial to the next stage of development. Whenever an experimental agent graduates or is dropped, the corresponding arm opens immediately for testing the next available new agent. Simulation studies show that MIDAS substantially outperforms the conventional approach. The proposed design yields a significantly higher probability for identifying the promising agents and dropping the futile agents. In addition, MIDAS requires only one master protocol, which streamlines trial conduct and substantially decreases the overhead burden. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

  12. Design requirements for a metal-smelting facility

    International Nuclear Information System (INIS)

    Williams, L.C.; Mack, J.E.

    1982-01-01

    Functional requirements for the smelting of metal scrap contaminated with low-enriched uranium in a Metal Smelting Faclity (MSF) have been determined. The process will be designed to smelt ferrous metal scrap that has accumulated at the Oak Ridge Gaseous Diffusion Plant (ORGDP) into one-ton ingots at a rate of 40 ingots per day (10,000 tons/year). Total scrap inventories at the ORGDP are currently estimated at 28,000 tons. The diffusion plant scrap is primarily contaminated with 100 to 200 ppm U at an enrichment of 0.5 to 1.5% 235 U. The scrap is considered special nuclear material (SNM) and cannot be handled by commercial smelters without specific licensing. Slagging will be performed to remove contaminants from the metal and concentrate them in the slag. Process systems will include scrap handling, size reduction, preheating and charging, melting and slagging, ingot casting and storage, and fume exhaust. The MSF has been proposed for FY 1984 line item funding

  13. Conceptual design considerations and neutronics of lithium fall laser fusion target chambers

    International Nuclear Information System (INIS)

    Meier, W.R.; Thomson, W.B.

    1978-01-01

    Atomics International and Lawrence Livermore Laboratory are involved in the conceptual design of a laser fusion power plant incorporating the lithium fall target chamber. In this paper we discuss some of the more important design considerations for the target chamber and evaluate its nuclear performance. Sizing and configuration of the fall, hydraulic effects, and mechanical design considerations are addressed. The nuclear aspects examined include tritium breeding, energy deposition, and radiation damage

  14. Conceptual design considerations and neutronics of lithium fall laser target chambers

    International Nuclear Information System (INIS)

    Meier, W.R.; Thomson, W.B.

    1978-01-01

    Atomics International and Lawrence Livermore Laboratory are involved in the conceptual design of a laser fusion power plant incorporating the lithium fall target chamber. In this paper we discuss some of the more important design considerations for the target chamber and evaluate its nuclear performance. Sizing and configuration of the fall, hydraulic effects, and mechanical design considerations are addressed. The nuclear aspects examined include tritium breeding, energy deposition, and radiation damage

  15. Conceptual design of the handling and storage system for spent target vessel

    Energy Technology Data Exchange (ETDEWEB)

    Adachi, Junichi; Sasaki, Shinobu; Kaminaga, Masanori; Hino, Ryutaro [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    2001-03-01

    A conceptual design of a handling and storage system for spent target vessels has been carried out, in order to establish spent target technology for the neutron scattering facility. The spent target vessels must be treated remotely with high reliability and safety, since they are highly activated and contain the poisonous mercury. The system is composed of a target exchange trolley to exchange the target vessel, remote handling equipment such as manipulators, airtight casks for the spent target vessel, storage pits and so on. This report presents the results of conceptual design study on a basic plan, a handling procedure, main devices and their arrangement of a handling and storage system for the spent target vessels. (author)

  16. Design and features of the target tracker of the Opera's target: study of the electron channel events

    International Nuclear Information System (INIS)

    Chon-Sen, N.

    2009-01-01

    Neutrino oscillations are now well acknowledged, the purpose of the Opera experiment is to show how ν τ appear in a ν μ beam. The ν μ beam is produced at CERN and crosses the earth crust on a distance of 732 km before being detected in the Gran-Sasso underground laboratory. The Opera experiment uses the technique of the photographic emulsion. The detector target is a series of walls of lead bricks, each brick being made of photographic emulsions intercalated with lead sheets. A target tracker enables the localization of the brick in which the neutrino interaction has happened. As soon as the brick is found, the brick is removed from the detector and the emulsion is developed and analysed. the target tracker is made up of plastic scintillator bars on which optic fibers are stuck to collect photons and send them to photomultipliers. The main purpose of this work is the calibration of the target tracker. The first chapter introduces the standard model, the neutrino and the neutrino oscillation phenomenon. The second chapter reviews the neutrino experiments worldwide. The third chapter describes the Opera experiment while chapter 4 and 5 are dedicated to the design and operation of the target tracker. The last chapter studies through simulation the behaviour of the target tracker when submitted to an electron beam in order to use it as a complementary tool for the identification of the τ → e channel. (A.C.)

  17. Target station design for a 1 MW pulsed spallation neutron source

    International Nuclear Information System (INIS)

    Russell, G.J.; Baker, G.D.; Brewton, R.J.

    1993-01-01

    Target stations are vital components of the 1 MW, next generation spallation neutron source proposed for LANSCE. By and large, target stations design determines the overall performance of the facility. Many traditional concepts will probably have to be rethought, and many new concepts will have to be put forward to meet the 1 MW challenge. This article gives a brief overview of the proposed neutron spallation source from the target station viewpoint, as well as the general philosophy adopted for the design of the LANSCE-II target stations. Some of the saliant concepts and features envisioned for LANSCE-II are briefly described

  18. Safety research needs for Russian-designed reactors. Requirements situation

    International Nuclear Information System (INIS)

    Brown, R. Allan; Holmstrom, Heikki; Reocreux, Michel; Schulz, Helmut; Liesch, Klaus; Santarossa, Giampiero; Hayamizu, Yoshitaka; Asmolov, Vladimir; Bolshov, Leonid; Strizhov, Valerii; Bougaenko, Sergei; Nikitin, Yuri N.; Proklov, Vladimir; Potapov, Alexandre; Kinnersly, Stephen R.; Voronin, Leonid M.; Honekamp, John R.; Frescura, Gianni M.; Maki, Nobuo; Reig, Javier; ); Bekjord, Eric S.; Rosinger, Herbert E.

    1998-01-01

    integrity must be verified, and material property data bases extended. - VVER severe accident research should focus on validation of codes for accident management procedures, and on extension and qualification of an appropriate data base for materials properties and their interactions. - RBMK thermal-hydraulic research is needed to improve the technical basis for further development of RBMK safety criteria. - Assessment of the integrity of the RBMK primary coolant circuit, and especially the fuel channel, requires urgent research. Methods of assessing RBMK pressure boundary integrity must be verified, and material property data bases extended. - RBMK severe accident research should focus on prevention of accidents and Accident Management for cases of loss of heat sink and Beyond Design-Basis Loss-of-Coolant Accidents. For these purposes, simple physical models and parametric codes need development and should be systematically used in plant specific analysis. Recommendations; - A Safety Research Strategic Plan should be developed. Such a plan sets goals, defines products, and describes when and how work will be done, including determination of research priorities. - Key players, including regulators, operators, plant designers and researchers should be involved in developing and implementing this plan and its execution and applying the results. - International cooperation in safety research should be encouraged for purposes of improving quality, preventing technical isolation and cost sharing. - New approaches, such as technical fora for specific technical topics, should be established to make safety research information in OECD countries available to researchers working on the safety of Russian-designed reactors

  19. Exploring cosmic origins with CORE: Survey requirements and mission design

    Science.gov (United States)

    Delabrouille, J.; de Bernardis, P.; Bouchet, F. R.; Achúcarro, A.; Ade, P. A. R.; Allison, R.; Arroja, F.; Artal, E.; Ashdown, M.; Baccigalupi, C.; Ballardini, M.; Banday, A. J.; Banerji, R.; Barbosa, D.; Bartlett, J.; Bartolo, N.; Basak, S.; Baselmans, J. J. A.; Basu, K.; Battistelli, E. S.; Battye, R.; Baumann, D.; Benoít, A.; Bersanelli, M.; Bideaud, A.; Biesiada, M.; Bilicki, M.; Bonaldi, A.; Bonato, M.; Borrill, J.; Boulanger, F.; Brinckmann, T.; Brown, M. L.; Bucher, M.; Burigana, C.; Buzzelli, A.; Cabass, G.; Cai, Z.-Y.; Calvo, M.; Caputo, A.; Carvalho, C.-S.; Casas, F. J.; Castellano, G.; Catalano, A.; Challinor, A.; Charles, I.; Chluba, J.; Clements, D. L.; Clesse, S.; Colafrancesco, S.; Colantoni, I.; Contreras, D.; Coppolecchia, A.; Crook, M.; D'Alessandro, G.; D'Amico, G.; da Silva, A.; de Avillez, M.; de Gasperis, G.; De Petris, M.; de Zotti, G.; Danese, L.; Désert, F.-X.; Desjacques, V.; Di Valentino, E.; Dickinson, C.; Diego, J. M.; Doyle, S.; Durrer, R.; Dvorkin, C.; Eriksen, H. K.; Errard, J.; Feeney, S.; Fernández-Cobos, R.; Finelli, F.; Forastieri, F.; Franceschet, C.; Fuskeland, U.; Galli, S.; Génova-Santos, R. T.; Gerbino, M.; Giusarma, E.; Gomez, A.; González-Nuevo, J.; Grandis, S.; Greenslade, J.; Goupy, J.; Hagstotz, S.; Hanany, S.; Handley, W.; Henrot-Versillé, S.; Hernández-Monteagudo, C.; Hervias-Caimapo, C.; Hills, M.; Hindmarsh, M.; Hivon, E.; Hoang, D. T.; Hooper, D. C.; Hu, B.; Keihänen, E.; Keskitalo, R.; Kiiveri, K.; Kisner, T.; Kitching, T.; Kunz, M.; Kurki-Suonio, H.; Lagache, G.; Lamagna, L.; Lapi, A.; Lasenby, A.; Lattanzi, M.; Le Brun, A. M. C.; Lesgourgues, J.; Liguori, M.; Lindholm, V.; Lizarraga, J.; Luzzi, G.; Macìas-P{érez, J. F.; Maffei, B.; Mandolesi, N.; Martin, S.; Martinez-Gonzalez, E.; Martins, C. J. A. P.; Masi, S.; Massardi, M.; Matarrese, S.; Mazzotta, P.; McCarthy, D.; Melchiorri, A.; Melin, J.-B.; Mennella, A.; Mohr, J.; Molinari, D.; Monfardini, A.; Montier, L.; Natoli, P.; Negrello, M.; Notari, A.; Noviello, F.; Oppizzi, F.; O'Sullivan, C.; Pagano, L.; Paiella, A.; Pajer, E.; Paoletti, D.; Paradiso, S.; Partridge, R. B.; Patanchon, G.; Patil, S. P.; Perdereau, O.; Piacentini, F.; Piat, M.; Pisano, G.; Polastri, L.; Polenta, G.; Pollo, A.; Ponthieu, N.; Poulin, V.; Prêle, D.; Quartin, M.; Ravenni, A.; Remazeilles, M.; Renzi, A.; Ringeval, C.; Roest, D.; Roman, M.; Roukema, B. F.; Rubiño-Martin, J.-A.; Salvati, L.; Scott, D.; Serjeant, S.; Signorelli, G.; Starobinsky, A. A.; Sunyaev, R.; Tan, C. Y.; Tartari, A.; Tasinato, G.; Toffolatti, L.; Tomasi, M.; Torrado, J.; Tramonte, D.; Trappe, N.; Triqueneaux, S.; Tristram, M.; Trombetti, T.; Tucci, M.; Tucker, C.; Urrestilla, J.; Väliviita, J.; Van de Weygaert, R.; Van Tent, B.; Vennin, V.; Verde, L.; Vermeulen, G.; Vielva, P.; Vittorio, N.; Voisin, F.; Wallis, C.; Wandelt, B.; Wehus, I. K.; Weller, J.; Young, K.; Zannoni, M.

    2018-04-01

    Future observations of cosmic microwave background (CMB) polarisation have the potential to answer some of the most fundamental questions of modern physics and cosmology, including: what physical process gave birth to the Universe we see today? What are the dark matter and dark energy that seem to constitute 95% of the energy density of the Universe? Do we need extensions to the standard model of particle physics and fundamental interactions? Is the ΛCDM cosmological scenario correct, or are we missing an essential piece of the puzzle? In this paper, we list the requirements for a future CMB polarisation survey addressing these scientific objectives, and discuss the design drivers of the COREmfive space mission proposed to ESA in answer to the "M5" call for a medium-sized mission. The rationale and options, and the methodologies used to assess the mission's performance, are of interest to other future CMB mission design studies. COREmfive has 19 frequency channels, distributed over a broad frequency range, spanning the 60–600 GHz interval, to control astrophysical foreground emission. The angular resolution ranges from 2' to 18', and the aggregate CMB sensitivity is about 2 μKṡarcmin. The observations are made with a single integrated focal-plane instrument, consisting of an array of 2100 cryogenically-cooled, linearly-polarised detectors at the focus of a 1.2-m aperture cross-Dragone telescope. The mission is designed to minimise all sources of systematic effects, which must be controlled so that no more than 10‑4 of the intensity leaks into polarisation maps, and no more than about 1% of E-type polarisation leaks into B-type modes. COREmfive observes the sky from a large Lissajous orbit around the Sun-Earth L2 point on an orbit that offers stable observing conditions and avoids contamination from sidelobe pick-up of stray radiation originating from the Sun, Earth, and Moon. The entire sky is observed repeatedly during four years of continuous scanning

  20. A trajectory design method via target practice for air-breathing hypersonic vehicle

    Science.gov (United States)

    Kong, Xue; Yang, Ming; Ning, Guodong; Wang, Songyan; Chao, Tao

    2017-11-01

    There are strong coupling interactions between aerodynamics and scramjet, this kind of aircraft also has multiple restrictions, such as the range and difference of dynamic pressure, airflow, and fuel. On the one hand, we need balance the requirement between maneuverability of vehicle and stabilization of scramjet. On the other hand, we need harmonize the change of altitude and the velocity. By describing aircraft's index system of climbing capability, acceleration capability, the coupling degree in aerospace, this paper further propose a rapid design method which based on target practice. This method aimed for reducing the coupling degree, it depresses the coupling between aircraft and engine in navigation phase, satisfy multiple restriction conditions to leave some control buffer and create good condition for control implementation. According to the simulation, this method could be used for multiple typical fly commissions such as climbing, acceleration or both.

  1. Progress in the Design of the Stabilized Liner Compressor for MTF/MIF Plasma Target Development

    Science.gov (United States)

    Frese, Sherry; Frese, Michael; Turchi, Peter; Gale, Don

    2016-10-01

    The Stabilized Liner Compressor (SLC) seeks to extend concepts for repetitive, rotationally stabilized, liquid-metal liners driven by free-pistons to much higher drive pressures (25 vs 5 kpsi) and faster implosion speeds (2000 vs 100 m/s) than previously demonstrated. Such extension is needed to enable experiments with magnetized-plasma targets presently offering sizes and lifetimes of 10's cm diam and 10's microsec. SLC represents the confluence of several difficult technologies, including pulsed high pressures, high-speed rotating machinery and alkali-metal (Na, NaK) handling. Solution of the two-dimensional, unsteady, compressible flow of a rotating liquid-metal liner requires advanced numerical techniques. We report the use of the 2-1/2 dimensional MHD code MACH2 to explore flow options, including magnetic flux compression, and to provide pulsed pressure distributions for mechanical design. Supported by ARPA-E ALPHA Program.

  2. Preliminary shielding analysis in support of the CSNS target station shutter neutron beam stop design

    Institute of Scientific and Technical Information of China (English)

    ZHANG Bin; CHEN Yi-Xue; WANG Wei-Jin; YANG Shou-Hai; WU Jun; YIN Wen; LIANG Tian-Jiao; JIA Xue-Jun

    2011-01-01

    The construction of China Spallation Neutron Source (CSNS) has been initiated in Dongguan,Guangdong, China.Thus a detailed radiation transport analysis of the shutter neutron beam stop is of vital importance. The analyses are performed using the coupled Monte Carlo and multi-dimensional discrete ordinates method. The target of calculations is to optimize the neutron beamline shielding design to guarantee personal safety and minimize cost. Successful elimination of the primary ray effects via the two-dimensional uncollided flux and the first collision source methodology is also illustrated. Two-dimensional dose distribution is calculated. The dose at the end of the neutron beam line is less than 2.5μSv/h. The models have ensured that the doses received by the hall staff members are below the standard limit required.

  3. Swedish contribution to the greenhouse effect and required reductions to meet the 550 ppmv target

    International Nuclear Information System (INIS)

    Lindell, Lina; Nilsson, Kristina

    2002-11-01

    According to the Swedish Parliament, the Swedish international climate strategy should focus on a stabilisation of the concentration of greenhouse gases in the atmosphere. An equilibrium concentration lower than 550 ppmv CO 2 -equivalents should be achieved by the end of this century. As an interim target, the yearly emissions should not exceed 4.5 tonnes CO 2 -equivalents per capita by 2050. In this study an inventory of Swedish emissions from 1834 until 2000, for the six greenhouse gases regulated by the Kyoto Protocol, is carried out. Future emission scenarios for carbon dioxide during the time period 2000-2050 are also defined. This data is used for estimating the contribution to the greenhouse effect both today and in the future. Further it is investigated if the 2050-target is sufficient for not exceeding an atmospheric concentration of 550 ppmv. The required reduction for 2100 to reach an equilibrium concentration below this level is also estimated. The Swedish contribution to the greenhouse effect today is about 30 % larger than it should be according to the fairness factor used in this study. The Swedish emission target set for 2050 is sufficient for not exceeding 550 ppmv by that year. However, to reach a stabilisation of the concentration below this level the emissions have to be reduced to 1.0-1.5 tonnes CO 2 -equivalents per capita by 2100

  4. Swedish contribution to the greenhouse effect and required reductions to meet the 550 ppmv target

    Energy Technology Data Exchange (ETDEWEB)

    Lindell, Lina; Nilsson, Kristina [Uppsala Univ. (Sweden). School of Engineering

    2002-11-01

    According to the Swedish Parliament, the Swedish international climate strategy should focus on a stabilisation of the concentration of greenhouse gases in the atmosphere. An equilibrium concentration lower than 550 ppmv CO{sub 2}-equivalents should be achieved by the end of this century. As an interim target, the yearly emissions should not exceed 4.5 tonnes CO{sub 2}-equivalents per capita by 2050. In this study an inventory of Swedish emissions from 1834 until 2000, for the six greenhouse gases regulated by the Kyoto Protocol, is carried out. Future emission scenarios for carbon dioxide during the time period 2000-2050 are also defined. This data is used for estimating the contribution to the greenhouse effect both today and in the future. Further it is investigated if the 2050-target is sufficient for not exceeding an atmospheric concentration of 550 ppmv. The required reduction for 2100 to reach an equilibrium concentration below this level is also estimated. The Swedish contribution to the greenhouse effect today is about 30 % larger than it should be according to the fairness factor used in this study. The Swedish emission target set for 2050 is sufficient for not exceeding 550 ppmv by that year. However, to reach a stabilisation of the concentration below this level the emissions have to be reduced to 1.0-1.5 tonnes CO{sub 2}-equivalents per capita by 2100.

  5. IFMIF Li target back-plate design integration and thermo-mechanical analysis

    International Nuclear Information System (INIS)

    Riccardi, B.; Roccella, S.; Micciche, G.

    2006-01-01

    The International Fusion Materials Irradiation Facility (IFMIF) is an accelerator-driven intense neutron source where fusion reactor candidate materials will be tested. The neutron flux is produced by means of a deuteron beam (current 250 mA, energy 40 MeV) that strikes a liquid lithium target circulating in a lithium loop. The support on which the liquid lithium flows, i.e. the back-plate, is the most heavily exposed component to neutron flux. A '' bayonet '' concept solution for the back-plate was proposed by ENEA with the objectives of improving the back-plate reliability and simplifying the remote handling procedures. On the base of this concept, a back-plate mock-up was fabricated and validated. Starting from the findings of the mock up design, a back-plate design integration exercise was carried out in order to check if the back-plate geometrical features are compatible with the target assembly and the Vertical Test Assemblies (VTA). The work carried out has demonstrated that even with the changes operated for the design integration (increase of in-plane dimensions and reduction of thickness) the bayonet concept is able to guarantee a tight connection to the target assembly. A thermo-mechanical analysis of the back-plate has been carried out by means of ABAQUS code. The thermal load used as input for the calculations, i.e. the neutron heat generation, has been estimated by means of Monte Carlo Mc-Delicious code. The two boundary constraint cases (full and minimum contact with target assembly) considered for each back-plate geometry option represent the extreme cases of the real operating condition of the plate. The influence of the contact heat exchange coefficient and the back-plate thickness has been also evaluated. For all these reasons, the results of the analysis can be considered as the domain of variability of the real working conditions. The results show that AISI 316L steel is not suitable as black-plate material: the stress induced in the plate, in

  6. Conceptual design of a high current ISOL target area at TRIUMF

    International Nuclear Information System (INIS)

    Beveridge, J.L.; Buchmann, L.; Clark, G.S.; Sprenger, H.; Thorson, I.; Vincent, J.; D'Auria, J.M.; Dombsky, M.

    1993-05-01

    Two similar conceptual designs for the handling of highly activated components at the target area of a high current radioactive beam facility have been investigated. The proposed designs are sufficiently flexible that practical detailed designs could be realized. Personnel exposure to radiation during the handling procedures is expected to be minimal. (author) 3 refs., 4 figs

  7. Target designs for the Brookhaven National Laboratory 5-MW pulsed spallation neutron source

    International Nuclear Information System (INIS)

    Ludewig, H.; Todosow, M.; Powell, J.R.

    1996-01-01

    A feasibility study of a compact high power density target for a spallation neutron source was under-taken. The target arrangement consists primarily of heavy metal, with appropriate cooling passages. A high intensity proton beam of intermediate energy is directed at the target, where it interacts with the heavy metal nuclei. The subsequent spallation reactions produce several neutrons per proton resulting in an intense neutron source. The proton beam is assumed to havean energy of 5 MW, and to be cyclic with a repetition rate of 10Hz and 50Hz. The study was divided into two broad sections. First, an analysis of preliminary target designs was undertaken to ensure the overall feasibility of the concepts involved in the design and eventual construction of such a high power density target. Second, two proposed target designs, based on the first set of analyses, are investigated in more detail. Special care is taken to ensure that the neutron fluxes in the moderator are at the desired level no material compatibility problems exist,and the target is able to operate in a reliable and safe manner. Several target materials, coolant types, and target arrangements are investigated in the first section. The second section concentrates on a single target material and geometric arrangement. However, several structural material choices continue to be investigated with the aim of minimizing the effects of structural heating, and associated thermally induced stresses. In the final section the conclusions of this preliminary study are summarized

  8. Interactive urban design using integrated planning requirements control

    NARCIS (Netherlands)

    Vries, de B.; Tabak, V.; Achten, H.H.

    2005-01-01

    Urban planning and urban design are separated disciplines. As a consequence, there is hardly any feedback from the urban design process to the urban planning process. To improve interaction between these two, an interactive urban design (IUD) tool has been developed. The tool is implemented in a

  9. Cryogenic propellant management: Integration of design, performance and operational requirements

    Science.gov (United States)

    Worlund, A. L.; Jamieson, J. R., Jr.; Cole, T. W.; Lak, T. I.

    1985-01-01

    The integration of the design features of the Shuttle elements into a cryogenic propellant management system is described. The implementation and verification of the design/operational changes resulting from design deficiencies and/or element incompatibilities encountered subsequent to the critical design reviews are emphasized. Major topics include: subsystem designs to provide liquid oxygen (LO2) tank pressure stabilization, LO2 facility vent for ice prevention, liquid hydrogen (LH2) feedline high point bleed, pogo suppression on the Space Shuttle Main Engine (SSME), LO2 low level cutoff, Orbiter/engine propellant dump, and LO2 main feedline helium injection for geyser prevention.

  10. An integrated in silico approach to design specific inhibitors targeting human poly(a-specific ribonuclease.

    Directory of Open Access Journals (Sweden)

    Dimitrios Vlachakis

    Full Text Available Poly(A-specific ribonuclease (PARN is an exoribonuclease/deadenylase that degrades 3'-end poly(A tails in almost all eukaryotic organisms. Much of the biochemical and structural information on PARN comes from the human enzyme. However, the existence of PARN all along the eukaryotic evolutionary ladder requires further and thorough investigation. Although the complete structure of the full-length human PARN, as well as several aspects of the catalytic mechanism still remain elusive, many previous studies indicate that PARN can be used as potent and promising anti-cancer target. In the present study, we attempt to complement the existing structural information on PARN with in-depth bioinformatics analyses, in order to get a hologram of the molecular evolution of PARNs active site. In an effort to draw an outline, which allows specific drug design targeting PARN, an unequivocally specific platform was designed for the development of selective modulators focusing on the unique structural and catalytic features of the enzyme. Extensive phylogenetic analysis based on all the publicly available genomes indicated a broad distribution for PARN across eukaryotic species and revealed structurally important amino acids which could be assigned as potentially strong contributors to the regulation of the catalytic mechanism of PARN. Based on the above, we propose a comprehensive in silico model for the PARN's catalytic mechanism and moreover, we developed a 3D pharmacophore model, which was subsequently used for the introduction of DNP-poly(A amphipathic substrate analog as a potential inhibitor of PARN. Indeed, biochemical analysis revealed that DNP-poly(A inhibits PARN competitively. Our approach provides an efficient integrated platform for the rational design of pharmacophore models as well as novel modulators of PARN with therapeutic potential.

  11. Design of a tripartite network for the prediction of drug targets

    Science.gov (United States)

    Kunimoto, Ryo; Bajorath, Jürgen

    2018-02-01

    Drug-target networks have aided in many target prediction studies aiming at drug repurposing or the analysis of side effects. Conventional drug-target networks are bipartite. They contain two different types of nodes representing drugs and targets, respectively, and edges indicating pairwise drug-target interactions. In this work, we introduce a tripartite network consisting of drugs, other bioactive compounds, and targets from different sources. On the basis of analog relationships captured in the network and so-called neighbor targets of drugs, new drug targets can be inferred. The tripartite network was found to have a stable structure and simulated network growth was accompanied by a steady increase in assortativity, reflecting increasing correlation between degrees of connected nodes leading to even network connectivity. Local drug environments in the tripartite network typically contained neighbor targets and revealed interesting drug-compound-target relationships for further analysis. Candidate targets were prioritized. The tripartite network design extends standard drug-target networks and provides additional opportunities for drug target prediction.

  12. Translating Genetic Research into Preventive Intervention: The Baseline Target Moderated Mediator Design.

    Science.gov (United States)

    Howe, George W; Beach, Steven R H; Brody, Gene H; Wyman, Peter A

    2015-01-01

    In this paper we present and discuss a novel research approach, the baseline target moderated mediation (BTMM) design, that holds substantial promise for advancing our understanding of how genetic research can inform prevention research. We first discuss how genetically informed research on developmental psychopathology can be used to identify potential intervention targets. We then describe the BTMM design, which employs moderated mediation within a longitudinal study to test whether baseline levels of intervention targets moderate the impact of the intervention on change in that target, and whether change in those targets mediates causal impact of preventive or treatment interventions on distal health outcomes. We next discuss how genetically informed BTMM designs can be applied to both microtrials and full-scale prevention trials. We use simulated data to illustrate a BTMM, and end with a discussion of some of the advantages and limitations of this approach.

  13. Translating genetic research into preventive intervention: The baseline target moderated mediator design

    Directory of Open Access Journals (Sweden)

    George W. Howe

    2016-01-01

    Full Text Available In this paper we present and discuss a novel research approach, the baseline target moderated mediation (BTMM design, that holds substantial promise for advancing our understanding of how genetic research can inform prevention research. We first discuss how genetically informed research on developmental psychopathology can be used to identify potential intervention targets. We then describe the BTMM design, which employs moderated mediation within a longitudinal study to test whether baseline levels of intervention targets moderate the impact of the intervention on change in that target, and whether change in those targets mediates causal impact of preventive or treatment interventions on distal health outcomes. We next discuss how genetically informed BTMM designs can be applied to both microtrials and full-scale prevention trials. We end with a discussion of some of the advantages and limitations of this approach.

  14. Optimal Design of Gradient Materials and Bi-Level Optimization of Topology Using Targets (BOTT)

    Science.gov (United States)

    Garland, Anthony

    The objective of this research is to understand the fundamental relationships necessary to develop a method to optimize both the topology and the internal gradient material distribution of a single object while meeting constraints and conflicting objectives. Functionally gradient material (FGM) objects possess continuous varying material properties throughout the object, and they allow an engineer to tailor individual regions of an object to have specific mechanical properties by locally modifying the internal material composition. A variety of techniques exists for topology optimization, and several methods exist for FGM optimization, but combining the two together is difficult. Understanding the relationship between topology and material gradient optimization enables the selection of an appropriate model and the development of algorithms, which allow engineers to design high-performance parts that better meet design objectives than optimized homogeneous material objects. For this research effort, topology optimization means finding the optimal connected structure with an optimal shape. FGM optimization means finding the optimal macroscopic material properties within an object. Tailoring the material constitutive matrix as a function of position results in gradient properties. Once, the target macroscopic properties are known, a mesostructure or a particular material nanostructure can be found which gives the target material properties at each macroscopic point. This research demonstrates that topology and gradient materials can both be optimized together for a single part. The algorithms use a discretized model of the domain and gradient based optimization algorithms. In addition, when considering two conflicting objectives the algorithms in this research generate clear 'features' within a single part. This tailoring of material properties within different areas of a single part (automated design of 'features') using computational design tools is a novel benefit

  15. National Ignition Facility subsystem design requirements optics assembly building (OAB) SSDR 1.2.2.3

    International Nuclear Information System (INIS)

    Kempel, P.; Hands, J.

    1996-01-01

    This Subsystem Design Requirement (SSDR) document establishes the performance, design, and verification requirements 'for the conventional building systems and subsystems of the Optics Assembly Building (OAB). These building system requirements are associated with housing and supporting the operational flow of personnel and materials throughout the OAB for preparing and repairing optical and mechanical components used in the National Ignition Facility (NIF) Laser and Target Building (LTAB). This SSDR addresses the following subsystems associated with the OAB: * Structural systems for the building spaces and operational-support equipment and building- support equipment. * Architectural building features associated with housing the space, operational cleanliness, and functional operation of the facility. * Heating, Ventilating, and Air Conditioning (HVAC) systems for maintaining a clean and thermally stable ambient environment within the facility. * Plumbing systems that provide potable water and sanitary facilities for the occupants and stormwater drainage for transporting rainwater. * Fire Protection systems that guard against fire damage to the facility and its contents. * Material handling equipment for transferring optical assemblies and other materials within building areas and to the LTAB. * Mechanical process piping systems for liquids and gases that provide cooling, cleaning, and other service to optical and mechanical components. * Electrical power and grounding systems that provide service to the building and equipment, including lighting distribution and communications systems for the facilities. * Instrumentation and control systems that ensure the safe operation of conventional facilities systems, such as those listed above. Generic design criteria, such as siting data, seismic requirements, utility availability, and other information that contributes to the OAB design, are not addressed in this document

  16. Design principles for target stations and methods of remote handling at PSI

    International Nuclear Information System (INIS)

    Steiner, E.W.

    1992-01-01

    Two design concepts for target stations used at Paul Scherrer Institute (PSI) are shown. The method of the remote handling of activated elements is described and some conclusions with respect to a radioactive beam facility are given

  17. Double-shell target designs for the Los Alamos Scientific Laboratory eight-beam laser system

    International Nuclear Information System (INIS)

    Kindel, J.M.; Stroscio, M.A.

    1978-03-01

    We investigate two double-pusher laser fusion targets, one that incorporates an outer exploding pusher shell and another that uses velocity multiplication. Specific designs are presented for the Los Alamos Scientific Laboratory Eight-Beam Laser System

  18. A Rationally Designed Agonist Defines Subfamily IIIA Abscisic Acid Receptors As Critical Targets for Manipulating Transpiration.

    Science.gov (United States)

    Vaidya, Aditya S; Peterson, Francis C; Yarmolinsky, Dmitry; Merilo, Ebe; Verstraeten, Inge; Park, Sang-Youl; Elzinga, Dezi; Kaundal, Amita; Helander, Jonathan; Lozano-Juste, Jorge; Otani, Masato; Wu, Kevin; Jensen, Davin R; Kollist, Hannes; Volkman, Brian F; Cutler, Sean R

    2017-11-17

    Increasing drought and diminishing freshwater supplies have stimulated interest in developing small molecules that can be used to control transpiration. Receptors for the plant hormone abscisic acid (ABA) have emerged as key targets for this application, because ABA controls the apertures of stomata, which in turn regulate transpiration. Here, we describe the rational design of cyanabactin, an ABA receptor agonist that preferentially activates Pyrabactin Resistance 1 (PYR1) with low nanomolar potency. A 1.63 Å X-ray crystallographic structure of cyanabactin in complex with PYR1 illustrates that cyanabactin's arylnitrile mimics ABA's cyclohexenone oxygen and engages the tryptophan lock, a key component required to stabilize activated receptors. Further, its sulfonamide and 4-methylbenzyl substructures mimic ABA's carboxylate and C6 methyl groups, respectively. Isothermal titration calorimetry measurements show that cyanabactin's compact structure provides ready access to high ligand efficiency on a relatively simple scaffold. Cyanabactin treatments reduce Arabidopsis whole-plant stomatal conductance and activate multiple ABA responses, demonstrating that its in vitro potency translates to ABA-like activity in vivo. Genetic analyses show that the effects of cyanabactin, and the previously identified agonist quinabactin, can be abolished by the genetic removal of PYR1 and PYL1, which form subclade A within the dimeric subfamily III receptors. Thus, cyanabactin is a potent and selective agonist with a wide spectrum of ABA-like activities that defines subfamily IIIA receptors as key target sites for manipulating transpiration.

  19. Impact of neutron and gamma radiation on the design of NIF diagnostics and target-bay systems

    Energy Technology Data Exchange (ETDEWEB)

    Eder, D.C.; Song, P.M.; Latkowski, J.F.; Reyes, S.; O' Brien, D.W.; Lee, F.D.; Young, B.K.; Koch, J.A.; Moran, M.J.; Watts, P.W.; Kimbrough, J.R.; Ng, E.W.; Landen, O.L.; MacGowan, B.J. [Lawrence Livermore National Lab., Livermore, CA (United States)

    2006-06-15

    The design of a wide range of components in and near the target bay of the National Ignition Facility (NIF) must allow for significant radiation from neutrons and gammas. Detailed 3-dimensional Monte Carlo simulations are critical to determine neutron and gamma fluxes for all target-bay components to allow optimization of location and auxiliary shielding. Demonstration of ignition poses unique challenges because of the large range (about 3 orders of magnitude) in the yield for any given attempt at ignition. Some diagnostics will provide data independent of yield, while others will provide data for lower yields and only survive high yields with little or no damage. In addition, for a given yield there is a more than 10 orders of magnitude range in neutron and gamma fluxes depending on location in the facility. For example, sensitive components in the diagnostic mezzanines and switchyards require auxiliary shielding for high-yield shots even though they are greater than 17 meters from target chamber center (TCC) and shielded by the 2 m-thick target-bay wall. In contrast, there are components 0.2 to 2 m from TCC with little or no shielding. For these components, particular attention is being made to use low-activation material because of the extremely high neutron loading levels. Many of the components closest to target center are designed to be single use to reduce worker dose from having to refurbish highly activated components. The cryogenic target positioner is an example where activation and ease of component replacement is an important part of the design. We are developing a design process for all target-bay systems that will assure reliable operation for the full range of planned yields. (authors)

  20. Impact of neutron and gamma radiation on the design of NIF diagnostics and target-bay systems

    Science.gov (United States)

    Eder, D. C.; Song, P. M.; Latkowski, J. F.; Reyes, S.; O'Brien, D. W.; Lee, F. D.; Young, B. K.; Koch, J. A.; Moran, M. J.; Watts, P. W.; Kimbrough, J. R.; Ng, E. W.; Landen, O. L.; MacGowan, B. J.

    2006-06-01

    The design of a wide range of components in and near the target bay of the National Ignition Facility (NIF) must allow for significant radiation from neutrons and gammas. Detailed 3D Monte Carlo simulations are critical to determine neutron and gamma fluxes for all target-bay components to allow optimization of location and auxiliary shielding. Demonstration of ignition poses unique challenges because of the large range (˜ 3 orders of magnitude) in the yield for any given attempt at ignition. Some diagnostics will provide data independent of yield, while others will provide data for lower yields and only survive high yields with little or no damage. In addition, for a given yield there is a more than 10 orders of magnitude range in neutron and gamma fluxes depending on location in the facility. For example, sensitive components in the diagnostic mezzanines and switchyards require auxiliary shielding for high-yield shots even though they are greater than 17 meters from target chamber center (TCC) and shielded by the 2 m-thick target-bay wall. In contrast, there are components 0.2 to 2 m from TCC with little or no shielding. For these components, particular attention is being made to use low-activation material because of the extremely high neutron loading levels. Many of the components closest to target center are designed to be single use to reduce worker dose from having to refurbish highly activated components. The cryogenic target positioner is an example where activation and ease of component replacement is an important part of the design. We are developing a design process for all target-bay systems that will assure reliable operation for the full range of planned yields.

  1. Evaluation of Information Requirements of Reliability Methods in Engineering Design

    DEFF Research Database (Denmark)

    Marini, Vinicius Kaster; Restrepo-Giraldo, John Dairo; Ahmed-Kristensen, Saeema

    2010-01-01

    This paper aims to characterize the information needed to perform methods for robustness and reliability, and verify their applicability to early design stages. Several methods were evaluated on their support to synthesis in engineering design. Of those methods, FMEA, FTA and HAZOP were selected...

  2. A requirements specification for a software design support system

    Science.gov (United States)

    Noonan, Robert E.

    1988-01-01

    Most existing software design systems (SDSS) support the use of only a single design methodology. A good SDSS should support a wide variety of design methods and languages including structured design, object-oriented design, and finite state machines. It might seem that a multiparadigm SDSS would be expensive in both time and money to construct. However, it is proposed that instead an extensible SDSS that directly implements only minimal database and graphical facilities be constructed. In particular, it should not directly implement tools to faciliate language definition and analysis. It is believed that such a system could be rapidly developed and put into limited production use, with the experience gained used to refine and evolve the systems over time.

  3. The design status of the liquid lithium target facility of IFMIF at the end of the engineering design activities

    Energy Technology Data Exchange (ETDEWEB)

    Nitti, F.S., E-mail: francesco.nitti@enea.it [IFMIF/EVEDA Project Team, Rokkasho Japan (Japan); Ibarra, A. [CIEMAT, Madrid (Spain); Ida, M. [IHI Corporation, Tokyo (Japan); Favuzza, P. [ENEA Research Center Firenze (Italy); Furukawa, T. [JAEA Research Center, Tokai-mura, Ibaraki (Japan); Groeschel, F. [KIT Research Center, Karlsruhe (Germany); Heidinger, R. [F4E Research Center, Garching (Germany); Kanemura, T. [JAEA Research Center, Tokai-mura, Ibaraki (Japan); Knaster, J. [IFMIF/EVEDA Project Team, Rokkasho Japan (Japan); Kondo, H. [JAEA Research Center, Tokai-mura, Ibaraki (Japan); Micchiche, G. [ENEA Research Center, Brasimone (Italy); Sugimoto, M. [JAEA Research Center, Rokkasho Japan (Japan); Wakai, E. [JAEA Research Center, Tokai-mura, Ibaraki (Japan)

    2015-11-15

    Highlights: • Results of validation and design activity for the Li loop facility of IFMIF. • Demonstration of Li target stability, with surface disturbance <1 mm. • Demonstration of start-up and shut down procedures of Li loop. • Complete design of the heat removal system and C and O purification system. • Conceptual design of N and H isotopes purification systems. - Abstract: The International Fusion Material Irradiation Facility (IFMIF) is an experimental facility conceived for qualifying and characterizing structural materials for nuclear fusion applications. The Engineering Validation and Engineering Design Activity (EVEDA) is a fundamental step towards the final design. It presented two mandates: the Engineering Validation Activities (EVA), still on-going, and the Engineering Design Activities (EDA) accomplished on schedule in June 2013. Five main facilities are identified in IFMIF, among which the Lithium Target Facility constituted a technological challenge overcome thanks to the success of the main validation challenges impacting the design. The design of the liquid Lithium Target Facility at the end of the EDA phase is here detailed.

  4. The design status of the liquid lithium target facility of IFMIF at the end of the engineering design activities

    International Nuclear Information System (INIS)

    Nitti, F.S.; Ibarra, A.; Ida, M.; Favuzza, P.; Furukawa, T.; Groeschel, F.; Heidinger, R.; Kanemura, T.; Knaster, J.; Kondo, H.; Micchiche, G.; Sugimoto, M.; Wakai, E.

    2015-01-01

    Highlights: • Results of validation and design activity for the Li loop facility of IFMIF. • Demonstration of Li target stability, with surface disturbance <1 mm. • Demonstration of start-up and shut down procedures of Li loop. • Complete design of the heat removal system and C and O purification system. • Conceptual design of N and H isotopes purification systems. - Abstract: The International Fusion Material Irradiation Facility (IFMIF) is an experimental facility conceived for qualifying and characterizing structural materials for nuclear fusion applications. The Engineering Validation and Engineering Design Activity (EVEDA) is a fundamental step towards the final design. It presented two mandates: the Engineering Validation Activities (EVA), still on-going, and the Engineering Design Activities (EDA) accomplished on schedule in June 2013. Five main facilities are identified in IFMIF, among which the Lithium Target Facility constituted a technological challenge overcome thanks to the success of the main validation challenges impacting the design. The design of the liquid Lithium Target Facility at the end of the EDA phase is here detailed.

  5. Conceptual design of a 10-MJ driver for a high gain target development facility

    International Nuclear Information System (INIS)

    Olson, R.E.

    1987-01-01

    Commercial application of inertial confinement fusion (ICF) will require inexpensive, high gain (>80) fusion targets. It is thought that the development of such targets will require a 5 to 10 year search effort utilizing a dedicated nuclear research facility with a driver capable of providing a 10 MJ, 300 to 1000 TW pulse of on-target energy. The Terget Development Facility (TDF) is a light ion driven concept for such a facility. A TDF driver based upon extrapolations from present-day pulsed power technology is described in the present paper

  6. Conceptual design of a 6-10 MJ driver for a high gain target development facility

    International Nuclear Information System (INIS)

    Olson, R.E.

    1986-01-01

    Commercial application of inertial confinement fusion would require low yield (≅200-500 MJ), high gain (≥80) fusion targets. It is thought that the development off such targets would reqiure a 5-10 year research program utilizing one or more dedicated nuclear facilities with drivers capable of delivering on-target pulses of 6-10 MJ at the rate of several shots per day. The ''Target Development Facility'' (TDF) is the light ion driven version of such a facility. A TDF driver concept based upon reasonable extrapolation from present-day technology is described in this paper

  7. Verification of the hydraulic design of the FMIT liquid lithium target

    International Nuclear Information System (INIS)

    Miles, R.R.; Annese, C.E.; Ingham, J.G.

    1983-01-01

    A liquid lithium target is being developed to generate a neutron flux for material testing in a fusion-like environment. The target consists of a thin, high speed, curved wall jet of lithium which is formed by an asymmetric nozzle. A prototype target was designed using potential flow analysis and was tested in water. Measurements of jet thickness and velocity in water and thickness in lithium were compared with isothermal design predictions and were shown to match within 1% for thickness and 5% for jet velocity

  8. An Interbacterial NAD(P)+ Glycohydrolase Toxin Requires Elongation Factor Tu for Delivery to Target Cells

    Energy Technology Data Exchange (ETDEWEB)

    Whitney, John C.; Quentin, Dennis; Sawai, Shin; LeRoux, Michele; Harding, Brittany N.; Ledvina, Hannah E.; Tran, Bao Q.; Robinson, Howard; Goo, Young Ah; Goodlett, David R.; Raunser, Stefan; Mougous, Joseph D.

    2015-10-08

    Type VI secretion (T6S) influences the composition of microbial communities by catalyzing the delivery of toxins between adjacent bacterial cells. Here, we demonstrate that a T6S integral membrane toxin from Pseudomonas aeruginosa, Tse6, acts on target cells by degrading the universally essential dinucleotides NAD+ and NADP+. Structural analyses of Tse6 show that it resembles mono-ADP-ribosyltransferase proteins, such as diphtheria toxin, with the exception of a unique loop that both excludes proteinaceous ADP-ribose acceptors and contributes to hydrolysis. We find that entry of Tse6 into target cells requires its binding to an essential housekeeping protein, translation elongation factor Tu (EF-Tu). These proteins participate in a larger assembly that additionally directs toxin export and provides chaperone activity. Visualization of this complex by electron microscopy defines the architecture of a toxin-loaded T6S apparatus and provides mechanistic insight into intercellular membrane protein delivery between bacteria.

  9. Applying technology to operator requirements in medical equipment design.

    Science.gov (United States)

    Woodring, P L

    1986-01-01

    The methodology used by the author consists of the following elements: Expose the design team to the user environment, followed by question and answer periods with users while still in the use environment. Place biomedical engineers in the leading teaching institutions where they will have day-to-day exposure to the use of products similar to the one being designed. Bring biomedical engineers back into the company as part of the design team. Expose concepts to focus groups while the product is in the definition stage. Bring a select group of users into the design review process. Evaluate the ease of use of the device as part of clinical trials. Establish a means of monitoring product performance after the product has been released. How well such a methodology will work in any particular environment is a function of management's recognition of the concept that ease of operator use is a vital element to the overall success of the product.

  10. REQUIREMENTS FOR HAZARDOUS WASTE LANDFILL DESIGN, CONSTRUCTION AND CLOSURE

    Science.gov (United States)

    This publication contains edited versions of the material presented at ten Technology Transfer seminars conducted in 1988 on this subject. Sections are included on design of clay and flexible membrane liners, leachate collector systems, and landfill covers. Construction quality a...

  11. 24 CFR 3280.305 - Structural design requirements.

    Science.gov (United States)

    2010-04-01

    ... wind pressures. (iii) One-piece metal roofing capable of resisting the design wind pressures for... deflection not to exceed one-eighth inch relative to floor framing. Perimeter wood joists of more than six...

  12. Large Wind Turbine Design Characteristics and R and D Requirements

    Science.gov (United States)

    Lieblein, S. (Editor)

    1979-01-01

    Detailed technical presentations on large wind turbine research and development activities sponsored by public and private organizations are presented. Both horizontal and vertical axis machines are considered with emphasis on their structural design.

  13. Basic national requirements for safe design, construction and operation

    International Nuclear Information System (INIS)

    Franzen, L.F.

    1980-01-01

    Nuclear power plants have to be save. Vendors and utilities operating such plants, are convinced that their plants meet this requirement. Who, however, is establishing the safety requirements to be met by those manufacturing and operating nuclear power plants. What are the mechanisms to control whether the features provided assure the required safety level. Who controls whether the required and planned safety features are really provided. Who is eventually responsible for assuring safety after commissioning of a nuclear power plant. These fundamental questions being raised in many discussions on safety and environmental protection are dealt with in the following sections: (1) Fundamental safety requirements on nuclear power plants, in which such items as risk, legal bases and licensing procedure are discussed, (2) Surveillance during construction, in which safety analysis report, siting, safety evaluation, document examination, quality assurance, and commissioning testing are dealt with, (3) Operating tests and conditions in which recurrent inspections, environmental protection during operation, investigation of abnormal occurences and backfitting requirements as reviewed, and (4) Safety philosophy and safety policy to conclude this presentation. The German approach to nuclear safety serves as an example for an effective way of assuring safe nuclear power. (orig.)

  14. Design and Optimization for the Windowless Target of the China Nuclear Waste Transmutation Reactor

    Directory of Open Access Journals (Sweden)

    Desheng Cheng

    2016-04-01

    Full Text Available A windowless spallation target can provide a neutron source and maintain neutron chain reaction for a subcritical reactor, and is a key component of China's nuclear waste transmutation of coupling accelerator and subcritical reactor. The main issue of the windowless target design is to form a stable and controllable free surface that can ensure that energy spectrum distribution is acquired for the neutron physical design when the high energy proton beam beats the lead–bismuth eutectic in the spallation target area. In this study, morphology and flow characteristics of the free surface of the windowless target were analyzed through the volume of fluid model using computational fluid dynamics simulation, and the results show that the outlet cross section size of the target is the key to form a stable and controllable free surface, as well as the outlet with an arc transition. The optimization parameter of the target design, in which the radius of outlet cross section is 60 ± 1 mm, is verified to form a stable and controllable free surface and to reduce the formation of air bubbles. This work can function as a reference for carrying out engineering design of windowless target and for verification experiments.

  15. Implications of Clinical Trial Design on Sample Size Requirements

    OpenAIRE

    Leon, Andrew C.

    2008-01-01

    The primary goal in designing a randomized controlled clinical trial (RCT) is to minimize bias in the estimate of treatment effect. Randomized group assignment, double-blinded assessments, and control or comparison groups reduce the risk of bias. The design must also provide sufficient statistical power to detect a clinically meaningful treatment effect and maintain a nominal level of type I error. An attempt to integrate neurocognitive science into an RCT poses additional challenges. Two par...

  16. Design basis ground motion (Ss) required on new regulatory guide

    International Nuclear Information System (INIS)

    Kamae, Katsuhiro

    2013-01-01

    New regulatory guide is enforced on July 8. Here, it is introduced how the design basis ground motion (Ss) for seismic design of nuclear power reactor facilities was revised on the new guide. Ss is formulated as two types of earthquake ground motions, earthquake ground motions with site specific earthquake source and with no such specific source locations. The latter is going to be revised based on the recent observed near source ground motions. (author)

  17. National Ignition Facility subsystem design requirements NIF site improvements SSDR 1.2.1

    International Nuclear Information System (INIS)

    Kempel, P.; Hands, J.

    1996-01-01

    This Subsystem Design Requirements (SSDR) document establishes the performance, design, and verification requirements associated with the NIF Project Site at Lawrence Livermore National Laboratory (LLNL) at Livermore, California. It identifies generic design conditions for all NIF Project facilities, including siting requirements associated with natural phenomena, and contains specific requirements for furnishing site-related infrastructure utilities and services to the NIF Project conventional facilities and experimental hardware systems. Three candidate sites were identified as potential locations for the NIF Project. However, LLNL has been identified by DOE as the preferred site because of closely related laser experimentation underway at LLNL, the ability to use existing interrelated infrastructure, and other reasons. Selection of a site other than LLNL will entail the acquisition of site improvements and infrastructure additional to those described in this document. This SSDR addresses only the improvements associated with the NIF Project site located at LLNL, including new work and relocation or demolition of existing facilities that interfere with the construction of new facilities. If the Record of Decision for the PEIS on Stockpile Stewardship and Management were to select another site, this SSDR would be revised to reflect the characteristics of the selected site. Other facilities and infrastructure needed to support operation of the NIF, such as those listed below, are existing and available at the LLNL site, and are not included in this SSDR. Office Building. Target Receiving and Inspection. General Assembly Building. Electro- Mechanical Shop. Warehousing and General Storage. Shipping and Receiving. General Stores. Medical Facilities. Cafeteria services. Service Station and Garage. Fire Station. Security and Badging Services

  18. Functional requirements for design of the Space Ultrareliable Modular Computer (SUMC) system simulator

    Science.gov (United States)

    Curran, R. T.; Hornfeck, W. A.

    1972-01-01

    The functional requirements for the design of an interpretive simulator for the space ultrareliable modular computer (SUMC) are presented. A review of applicable existing computer simulations is included along with constraints on the SUMC simulator functional design. Input requirements, output requirements, and language requirements for the simulator are discussed in terms of a SUMC configuration which may vary according to the application.

  19. Proposal for elicitation and analysis of environmental requirements into the construction design process: a case study

    Directory of Open Access Journals (Sweden)

    Camila Pegoraro

    2010-05-01

    Full Text Available Proposal: As new demands from sustainable development, environmental requirements arise as another challenge to design process management. It is already known that companies which design buildings are usually exposed to many managerial difficulties. Faced to the environmental demands, these companies require new facilities to align environmental requirements to the business goals and to include them properly in design process. This paper is based on a case study in a construction company, which was developed through interviews and document analysis. It is intended to present a procedure for the project environmental requirements elicitation, organization and analysis, which is based on the requirements engineering (ER concepts. As results it was concluded that the ER concepts are useful for the environmental requirements integration into the design process and that strategic planning should give directions for the effective environmental requirements adherence. Moreover, a procedure for environmental requirements modeling is proposed. Key-words: Design process, Requirements management, Environmental requirements, Construction

  20. RobOKoD: microbial strain design for (over)production of target compounds.

    Science.gov (United States)

    Stanford, Natalie J; Millard, Pierre; Swainston, Neil

    2015-01-01

    Sustainable production of target compounds such as biofuels and high-value chemicals for pharmaceutical, agrochemical, and chemical industries is becoming an increasing priority given their current dependency upon diminishing petrochemical resources. Designing these strains is difficult, with current methods focusing primarily on knocking-out genes, dismissing other vital steps of strain design including the overexpression and dampening of genes. The design predictions from current methods also do not translate well-into successful strains in the laboratory. Here, we introduce RobOKoD (Robust, Overexpression, Knockout and Dampening), a method for predicting strain designs for overproduction of targets. The method uses flux variability analysis to profile each reaction within the system under differing production percentages of target-compound and biomass. Using these profiles, reactions are identified as potential knockout, overexpression, or dampening targets. The identified reactions are ranked according to their suitability, providing flexibility in strain design for users. The software was tested by designing a butanol-producing Escherichia coli strain, and was compared against the popular OptKnock and RobustKnock methods. RobOKoD shows favorable design predictions, when predictions from these methods are compared to a successful butanol-producing experimentally-validated strain. Overall RobOKoD provides users with rankings of predicted beneficial genetic interventions with which to support optimized strain design.

  1. N-Glycosylation of Lipocalin 2 Is Not Required for Secretion or Exosome Targeting

    Directory of Open Access Journals (Sweden)

    Erawan Borkham-Kamphorst

    2018-04-01

    Full Text Available Lipocalin 2 (LCN2 is a highly conserved secreted adipokine acting as a serum transport protein for small hydrophobic molecules such as fatty acids and steroids. In addition, LCN2 limits bacterial growth by sequestering iron-containing siderophores and further protects against intestinal inflammation and tumorigenesis associated with alterations in the microbiota. Human LCN2 contains one N-glycosylation site conserved in other species. It was postulated that this post-translational modification could facilitate protein folding, protects from proteolysis, is required for proper trafficking from the Golgi apparatus to the cell surface, and might be relevant for effective secretion. We here show that the homologous nucleoside antibiotic tunicamycin blocks N-linked glycosylation but not secretion of LCN2 in primary murine hepatocytes, derivatives thereof, human lung carcinoma cell line A549, and human prostate cancer cell line PC-3. Moreover, both the glycosylated and the non-glycosylated LCN2 variants are equally targeted to exosomes, demonstrating that this post-translational modification is not necessary for proper trafficking of LCN2 into these membranous extracellular vesicles. Furthermore, a hydrophobic cluster analysis revealed that the N-glycosylation site is embedded in a highly hydrophobic evolutionarily conserved surrounding. In sum, our data indicate that the N-glycosylation of LCN2 is not required for proper secretion and exosome cargo recruitment in different cell types, but might be relevant to increase overall solubility.

  2. Airport Planning and Design - Legal and Professional Competence Requirements

    Science.gov (United States)

    Kazda, Antonin

    2017-12-01

    Airport design and planning considerably differs from the design of other transport infrastructure. The reasons are the wide scope of regulation in civil aviation and the lack of links between the Civil Aviation Act and the Building Act. The effect is that the sequence of procedures, negotiation, and/or document approval is not clearly defined. The situation is further complicated by the fact that an airport is a unique construction both for the investor and for the local building authority. The paper is an outcome of our research, building on long-term experience in airport planning and design, and the elucidation of planning and approval processes with experts from the Transport Authority and the Ministry of Transport and Construction of the Slovak Republic.

  3. Implications of clinical trial design on sample size requirements.

    Science.gov (United States)

    Leon, Andrew C

    2008-07-01

    The primary goal in designing a randomized controlled clinical trial (RCT) is to minimize bias in the estimate of treatment effect. Randomized group assignment, double-blinded assessments, and control or comparison groups reduce the risk of bias. The design must also provide sufficient statistical power to detect a clinically meaningful treatment effect and maintain a nominal level of type I error. An attempt to integrate neurocognitive science into an RCT poses additional challenges. Two particularly relevant aspects of such a design often receive insufficient attention in an RCT. Multiple outcomes inflate type I error, and an unreliable assessment process introduces bias and reduces statistical power. Here we describe how both unreliability and multiple outcomes can increase the study costs and duration and reduce the feasibility of the study. The objective of this article is to consider strategies that overcome the problems of unreliability and multiplicity.

  4. Medical requirements for design of endoscopes for otolaryngology

    Science.gov (United States)

    Parekh, Jai; Pankratov, Michail M.; Poe, Dennis S.; Rebeiz, Elie E.; Shapshay, Stanley M.

    1993-07-01

    Endoscopy has revolutionized the field of medicine and surgery by aiding the clinician in diagnostic and therapeutic modalities of patient care. Endoscopy in Otolaryngology has provided the surgeon with unique access to areas of the head and neck which were previously inaccessible for direct inspection in an atraumatic and minimally invasive fashion. Specific areas of Otolaryngology where endoscopy has made advances are the rhinology and otology. The relevant anatomy, clinical requirements, and `state of the art' endoscopic techniques are discussed for these areas. Further advances in endoscopy for otolaryngology requires the cooperation from both the clinical and technical standpoints.

  5. Computational design of trimeric influenza-neutralizing proteins targeting the hemagglutinin receptor binding site

    Energy Technology Data Exchange (ETDEWEB)

    Strauch, Eva-Maria; Bernard, Steffen M.; La, David; Bohn, Alan J.; Lee, Peter S.; Anderson, Caitlin E.; Nieusma, Travis; Holstein, Carly A.; Garcia, Natalie K.; Hooper, Kathryn A.; Ravichandran, Rashmi; Nelson, Jorgen W.; Sheffler, William; Bloom, Jesse D.; Lee, Kelly K.; Ward, Andrew B.; Yager, Paul; Fuller, Deborah H.; Wilson, Ian A.; Baker , David (UWASH); (Scripps); (FHCRC)

    2017-06-12

    Many viral surface glycoproteins and cell surface receptors are homo-oligomers1, 2, 3, 4, and thus can potentially be targeted by geometrically matched homo-oligomers that engage all subunits simultaneously to attain high avidity and/or lock subunits together. The adaptive immune system cannot generally employ this strategy since the individual antibody binding sites are not arranged with appropriate geometry to simultaneously engage multiple sites in a single target homo-oligomer. We describe a general strategy for the computational design of homo-oligomeric protein assemblies with binding functionality precisely matched to homo-oligomeric target sites5, 6, 7, 8. In the first step, a small protein is designed that binds a single site on the target. In the second step, the designed protein is assembled into a homo-oligomer such that the designed binding sites are aligned with the target sites. We use this approach to design high-avidity trimeric proteins that bind influenza A hemagglutinin (HA) at its conserved receptor binding site. The designed trimers can both capture and detect HA in a paper-based diagnostic format, neutralizes influenza in cell culture, and completely protects mice when given as a single dose 24 h before or after challenge with influenza.

  6. Integrating speech technology to meet crew station design requirements

    Science.gov (United States)

    Simpson, Carol A.; Ruth, John C.; Moore, Carolyn A.

    The last two years have seen improvements in speech generation and speech recognition technology that make speech I/O for crew station controls and displays viable for operational systems. These improvements include increased robustness of algorithm performance in high levels of background noise, increased vocabulary size, improved performance in the connected speech mode, and less speaker dependence. This improved capability makes possible far more sophisticated user interface design than was possible with earlier technology. Engineering, linguistic, and human factors design issues are discussed in the context of current voice I/O technology performance.

  7. Safety of Nuclear Power Plants: Design. Specific Safety Requirements (Chinese Ed.)

    International Nuclear Information System (INIS)

    2012-01-01

    On the basis of the principles included in the Fundamental Safety Principles, IAEA Safety Standards Series No. SF-1, this Safety Requirements publication establishes requirements applicable to the design of nuclear power plants. It covers the design phase and provides input for the safe operation of the power plant. It elaborates on the safety objective, safety principles and concepts that provide the basis for deriving the safety requirements that must be met for the design of a nuclear power plant. Contents: 1. Introduction; 2. Applying the safety principles and concepts; 3. Management of safety in design; 4. Principal technical requirements; 5. General plant design; 6. Design of specific plant systems.

  8. Safety of Nuclear Power Plants: Design. Specific Safety Requirements (French Ed.)

    International Nuclear Information System (INIS)

    2012-01-01

    On the basis of the principles included in the Fundamental Safety Principles, IAEA Safety Standards Series No. SF-1, this Safety Requirements publication establishes requirements applicable to the design of nuclear power plants. It covers the design phase and provides input for the safe operation of the power plant. It elaborates on the safety objective, safety principles and concepts that provide the basis for deriving the safety requirements that must be met for the design of a nuclear power plant. Contents: 1. Introduction; 2. Applying the safety principles and concepts; 3. Management of safety in design; 4. Principal technical requirements; 5. General plant design; 6. Design of specific plant systems.

  9. Safety of Nuclear Power Plants: Design. Specific Safety Requirements (Arabic Ed.)

    International Nuclear Information System (INIS)

    2012-01-01

    On the basis of the principles included in the Fundamental Safety Principles, IAEA Safety Standards Series No. SF-1, this Safety Requirements publication establishes requirements applicable to the design of nuclear power plants. It covers the design phase and provides input for the safe operation of the power plant. It elaborates on the safety objective, safety principles and concepts that provide the basis for deriving the safety requirements that must be met for the design of a nuclear power plant. Contents: 1. Introduction; 2. Applying the safety principles and concepts; 3. Management of safety in design; 4. Principal technical requirements; 5. General plant design; 6. Design of specific plant systems.

  10. Designing interactive ambient multimedia applications : requirements and implementation challenges

    NARCIS (Netherlands)

    Obrenovic, Z.; Nack, F.-M.; Hardman, H.L.

    2006-01-01

    Ambient intelligence opens new possibilities for interactive multimedia, leading towards applications where the selection, generation and playback of multimedia content can be directed and influenced by multiple users in an ambient sensor network. In this paper, we derive the basic requirements for

  11. 40 CFR 264.221 - Design and operating requirements.

    Science.gov (United States)

    2010-07-01

    ..., and other equipment; and human error. (h) A surface impoundment must have dikes that are designed... (CONTINUED) STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL FACILITIES... external hydrogeologic forces), physical contact with the waste or leachate to which they are exposed...

  12. 40 CFR 264.273 - Design and operating requirements.

    Science.gov (United States)

    2010-07-01

    ... the facility permit how the owner or operator will design, construct, operate, and maintain the land..., construct, operate, and maintain the treatment zone to minimize run-off of hazardous constituents during the... maintain a run-on control system capable of preventing flow onto the treatment zone during peak discharge...

  13. Small nuclear reactor safety design requirements for autonomous operation

    International Nuclear Information System (INIS)

    Kozier, K.S.; Kupca, S.

    1997-01-01

    Small nuclear power reactors offer compelling safety advantages in terms of the limited consequences that can arise from major accident events and the enhanced ability to use reliable, passive means to eliminate their occurrence by design. Accordingly, for some small reactor designs featuring a high degree of safety autonomy, it may be-possible to delineate a ''safety envelope'' for a given set of reactor circumstances within which safe reactor operation can be guaranteed without outside intervention for time periods of practical significance (i.e., days or weeks). The capability to operate a small reactor without the need for highly skilled technical staff permanently present, but with continuous remote monitoring, would aid the economic case for small reactors, simplify their use in remote regions and enhance safety by limiting the potential for accidents initiated by inappropriate operator action. This paper considers some of the technical design options and issues associated with the use of small power reactors in an autonomous mode for limited periods. The focus is on systems that are suitable for a variety of applications, producing steam for electricity generation, district heating, water desalination and/or marine propulsion. Near-term prospects at low power levels favour the use of pressurized, light-water-cooled reactor designs, among which those having an integral core arrangement appear to offer cost and passive-safety advantages. Small integral pressurized water reactors have been studied in many countries, including the test operation of prototype systems. (author)

  14. 30 CFR 74.7 - Design and construction requirements.

    Science.gov (United States)

    2010-07-01

    ... shall measure respirable coal mine dust concentrations accurately, as specified under § 74.8, for an end... 15.1 through 15.407 (FCC Radio Frequency Devices). Persons must proceed in accordance with IEEE Std... CPDM shall be designed and constructed to remain safe and measure respirable coal mine dust...

  15. Conceptual design report for the University of Rochester cryogenic target delivery system

    Energy Technology Data Exchange (ETDEWEB)

    Fagaly, R.L.; Alexander, N.B.; Bourque, R.F.; Dahms, C.F.; Lindgren, J.R.; Miller, W.J. (General Atomics, San Diego, CA (United States)); Bittner, D.N.; Hendricks, C.D. (W.J. Schafer Associates, Livermore, CA (United States))

    1993-05-01

    The upgrade of the Omega laser at the University of Rochester's Laboratory for Laser Energetics (UR/LLE) will result in a need for large targets filled with D[sub 2] or Dt and maintained at cryogenic temperatures. This mandates a cryogenic target delivery system capable of filling, layering, characterizing and delivering cryogenic targets to the Omega Upgrade target chamber. The program goal is to design, construct, and test the entire target delivery system by June 1996. When completed (including an operational demonstration), the system will be shipped to Rochester for reassembly and commissioning in time for the Omega Upgrade cryogenic campaign, scheduled to start in 1998. General Atomics has been assigned the task of developing the conceptual design for the cryogenic target delivery system. Design and fabrication activities will be closely coordinated with the University of Rochester, Lawrence Livermore National laboratory (LLNL) and Los Alamos National Laboratory (LANL), drawing upon their knowledge base in fuel layering and cryogenic characterization. The development of a target delivery system for Omega could also benefit experiments at Lawrence Livermore National Laboratory and the other ICF Laboratories in that the same technologies could be applied to NOVA, the National Ignition Facility or the future Laboratory Microfusion Facility.

  16. Conceptual design report for the University of Rochester cryogenic target delivery system

    Energy Technology Data Exchange (ETDEWEB)

    Fagaly, R.L.; Alexander, N.B.; Bourque, R.F.; Dahms, C.F.; Lindgren, J.R.; Miller, W.J. [General Atomics, San Diego, CA (United States); Bittner, D.N.; Hendricks, C.D. [W.J. Schafer Associates, Livermore, CA (US)

    1993-05-01

    The upgrade of the Omega laser at the University of Rochester`s Laboratory for Laser Energetics (UR/LLE) will result in a need for large targets filled with D{sub 2} or Dt and maintained at cryogenic temperatures. This mandates a cryogenic target delivery system capable of filling, layering, characterizing and delivering cryogenic targets to the Omega Upgrade target chamber. The program goal is to design, construct, and test the entire target delivery system by June 1996. When completed (including an operational demonstration), the system will be shipped to Rochester for reassembly and commissioning in time for the Omega Upgrade cryogenic campaign, scheduled to start in 1998. General Atomics has been assigned the task of developing the conceptual design for the cryogenic target delivery system. Design and fabrication activities will be closely coordinated with the University of Rochester, Lawrence Livermore National laboratory (LLNL) and Los Alamos National Laboratory (LANL), drawing upon their knowledge base in fuel layering and cryogenic characterization. The development of a target delivery system for Omega could also benefit experiments at Lawrence Livermore National Laboratory and the other ICF Laboratories in that the same technologies could be applied to NOVA, the National Ignition Facility or the future Laboratory Microfusion Facility.

  17. Conceptual design report for the University of Rochester cryogenic target delivery system

    International Nuclear Information System (INIS)

    Fagaly, R.L.; Alexander, N.B.; Bourque, R.F.; Dahms, C.F.; Lindgren, J.R.; Miller, W.J.; Bittner, D.N.; Hendricks, C.D.

    1993-05-01

    The upgrade of the Omega laser at the University of Rochester's Laboratory for Laser Energetics (UR/LLE) will result in a need for large targets filled with D 2 or Dt and maintained at cryogenic temperatures. This mandates a cryogenic target delivery system capable of filling, layering, characterizing and delivering cryogenic targets to the Omega Upgrade target chamber. The program goal is to design, construct, and test the entire target delivery system by June 1996. When completed (including an operational demonstration), the system will be shipped to Rochester for reassembly and commissioning in time for the Omega Upgrade cryogenic campaign, scheduled to start in 1998. General Atomics has been assigned the task of developing the conceptual design for the cryogenic target delivery system. Design and fabrication activities will be closely coordinated with the University of Rochester, Lawrence Livermore National laboratory (LLNL) and Los Alamos National Laboratory (LANL), drawing upon their knowledge base in fuel layering and cryogenic characterization. The development of a target delivery system for Omega could also benefit experiments at Lawrence Livermore National Laboratory and the other ICF Laboratories in that the same technologies could be applied to NOVA, the National Ignition Facility or the future Laboratory Microfusion Facility

  18. Designing multi-targeted agents: An emerging anticancer drug discovery paradigm.

    Science.gov (United States)

    Fu, Rong-Geng; Sun, Yuan; Sheng, Wen-Bing; Liao, Duan-Fang

    2017-08-18

    The dominant paradigm in drug discovery is to design ligands with maximum selectivity to act on individual drug targets. With the target-based approach, many new chemical entities have been discovered, developed, and further approved as drugs. However, there are a large number of complex diseases such as cancer that cannot be effectively treated or cured only with one medicine to modulate the biological function of a single target. As simultaneous intervention of two (or multiple) cancer progression relevant targets has shown improved therapeutic efficacy, the innovation of multi-targeted drugs has become a promising and prevailing research topic and numerous multi-targeted anticancer agents are currently at various developmental stages. However, most multi-pharmacophore scaffolds are usually discovered by serendipity or screening, while rational design by combining existing pharmacophore scaffolds remains an enormous challenge. In this review, four types of multi-pharmacophore modes are discussed, and the examples from literature will be used to introduce attractive lead compounds with the capability of simultaneously interfering with different enzyme or signaling pathway of cancer progression, which will reveal the trends and insights to help the design of the next generation multi-targeted anticancer agents. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  19. Autonomous Rover Traverse and Precise Arm Placement on Remotely Designated Targets

    Science.gov (United States)

    Felder, Michael; Nesnas, Issa A.; Pivtoraiko, Mihail; Kelly, Alonzo; Volpe, Richard

    2011-01-01

    Exploring planetary surfaces typically involves traversing challenging and unknown terrain and acquiring in-situ measurements at designated locations using arm-mounted instruments. We present field results for a new implementation of an autonomous capability that enables a rover to traverse and precisely place an arm-mounted instrument on remote targets. Using point-and-click mouse commands, a scientist designates targets in the initial imagery acquired from the rover's mast cameras. The rover then autonomously traverse the rocky terrain for a distance of 10 - 15 m, tracks the target(s) of interest during the traverse, positions itself for approaching the target, and then precisely places an arm-mounted instrument within 2-3 cm from the originally designated target. The rover proceeds to acquire science measurements with the instrument. This work advances what has been previously developed and integrated on the Mars Exploration Rovers by using algorithms that are capable of traversing more rock-dense terrains, enabling tight thread-the-needle maneuvers. We integrated these algorithms on the newly refurbished Athena Mars research rover and fielded them in the JPL Mars Yard. We conducted 43 runs with targets at distances ranging from 5 m to 15 m and achieved a success rate of 93% for placement of the instrument within 2-3 cm.

  20. Requirements for nuclear data from ITER/FER nuclear design

    International Nuclear Information System (INIS)

    Maki, Koichi

    1991-01-01

    Considering ITER and FER activities and future programme of fusion reactor developments, the present situations in fusion neutronics were explained up to now from the previous fusion nuclear data specialist meeting. Vicissitude of development of FUSION-J3 was also explained. From these discussions we clarified the required accuracies in nuclear data, their time limits and their priorities of nuclides to be improved for fusion reactor developments. (author)

  1. Robust design requirements specification: a quantitative method for requirements development using quality loss functions

    DEFF Research Database (Denmark)

    Pedersen, Søren Nygaard; Christensen, Martin Ebro; Howard, Thomas J.

    2016-01-01

    Product requirements serve many purposes in the product development process. Most importantly, they are meant to capture and facilitate product goals and acceptance criteria, as defined by stakeholders. Accurately communicating stakeholder goals and acceptance criteria can be challenging and more...

  2. Ergonomic requirements to control room design - evaluation method

    International Nuclear Information System (INIS)

    Hinz, W.

    1985-01-01

    The method of evaluation introduced is the result of work carried out by the sub-committee 'Control Room Design' of the Engineering Standards Committee in DIN Standards, Ergonomy. This committee compiles standards for the design of control rooms (instrumentation and control) for the monitoring and operation of process engineering cycles. With the agreement of the committee - whom we wish to take the opportunity of thanking at this point for their constructive collaboration - a planned partial standard will be introduced thematically in the following, in order that knowledge gained from the discussion can be included in further work on the subject. The matter in question is a procedure for the qualitative evaluation of the duties to be performed under the control of operators in order that an assessment can be made of existing control concepts or such concepts as are to be found in the draft phase. (orig./GL) [de

  3. Ohio River navigation investment model: Requirements and model design

    Energy Technology Data Exchange (ETDEWEB)

    Bronzini, M.S.; Curlee, T.R.; Leiby, P.N.; Southworth, F.; Summers, M.S.

    1998-01-01

    Oak Ridge National Laboratory is assisting the US Army Corps of Engineers in improving its economic analysis procedures for evaluation of inland waterway investment projects along the Ohio River System. This paper describes the context and design of an integrated approach to calculating the system-wide benefits from alternative combinations of lock and channel improvements, providing an ability to project the cost savings from proposed waterway improvements in capacity and reliability for up to fifty years into the future. The design contains an in-depth treatment of the levels of risk and uncertainty associated with different multi-year lock and channel improvement plans, including the uncertainty that results from a high degree of interaction between the many different waterway system components.

  4. Organizational Information Requirements, Media Richness and Structural Design

    OpenAIRE

    Richard L. Daft; Robert H. Lengel

    1986-01-01

    This paper answers the question, "Why do organizations process information?" Uncertainty and equivocality are defined as two forces that influence information processing in organizations. Organization structure and internal systems determine both the amount and richness of information provided to managers. Models are proposed that show how organizations can be designed to meet the information needs of technology, interdepartmental relations, and the environment. One implication for managers i...

  5. Handling Quality Requirements for Advanced Aircraft Design: Longitudinal Mode

    Science.gov (United States)

    1979-08-01

    true integracion of a variety of subsystems. The motivation for digital control is simply stated: expensive hardware-intensive control logic and...control. The discussions of system: "architecture" (bus structure, single vs multiple central processing units (CPUs), input/output design, etc.) are...more complex than multiplication by’a constant. This would occur, for example, if one * 22 4 .. -. wished to mechanize a pitch damper. How does one

  6. Site characterization requirements for nuclear-cratering design

    International Nuclear Information System (INIS)

    Terhune, R.W.; Carlson, R.C.

    1977-01-01

    A material properties measurement program for the design of large engineering nuclear-excavation projects by computer calculation is presented. Material properties of the site and their relative effect on crater size are analyzed and ordered in relation to their importance in determining the overall cratering efficiency. The measurement program includes both in situ logging and laboratory measurement of core samples, together with the reason for each measurement and its use in the calculations

  7. Mammalian target of rapamycin activity is required for expansion of CD34(+) hematopoietic progenitor cells

    NARCIS (Netherlands)

    Geest, Christian R.; Zwartkruis, Fried J.; Vellenga, Edo; Coffer, Paul J.; Buitenhuis, Miranda

    Background The mammalian target of rapamycin is a conserved protein kinase known to regulate protein synthesis, cell size and proliferation. Aberrant regulation of mammalian target of rapamycin activity has been observed in hematopoietic malignancies, including acute leukemias and myelodysplastic

  8. FEA Analysis of AP-0 Target Hall Collection Lens (Current Design)

    International Nuclear Information System (INIS)

    Hurh, P.G.; Tang, Z.

    2001-01-01

    The AP-0 Target Hall Collection Lens is a pulsed device which focuses anti-protons just downstream of the Target. Since the angles at which the anti-protons depart the Target can be quite large, a very high focusing strength is required to maximize anti-proton capture into the downstream Debuncher Ring. The current design of the Collection Lens was designed to operate with a focusing gradient of 1,000 T/m. However, multiple failures of early devices resulted in lowering the normal operating gradient to about 750 T/m. At this gradient, the Lens design fares much better, lasting several million pulses, but ultimately still fails. A Finite Element Analysis (FEA) has been performed on this Collection Lens design to help determine the cause and/or nature of the failures. The Collection Lens magnetic field is created by passing high current through a central conductor cylinder. A uniform current distribution through the cylinder will create a tangential or azimuthal magnetic field that varies linearly from zero at the center of the cylinder to a maximum at the outer surface of the cylinder. Anti-proton particles passing through this cylinder (along the longitudinal direction) will see an inward focusing kick back toward the center of the cylinder proportional to the magnetic field strength. For the current Lens design a gradient of 1,000 T/m requires a current of about 580,000 amps. Since the DC power and cooling requirements would be prohibitive, the Lens is operated in a pulsed mode. Each pulse is half sine wave in shape with a pulse duration of about 350 microseconds. Because of the skin effect, the most uniform current density actually occurs about two-thirds of the way through the pulse. This means that the maximum current of the pulse is actually higher than that required in the DC case (about 670,000 amps). Since the beam must pass through the central conductor cylinder it must be made of a conducting material that is also very 'transparent' to the beam. For the

  9. ITER-EDA physics design requirements and plasma performance assessments

    International Nuclear Information System (INIS)

    Uckan, N.A.; Galambos, J.; Wesley, J.; Boucher, D.; Perkins, F.; Post, D.; Putvinski, S.

    1996-01-01

    Physics design guidelines, plasma performance estimates, and sensitivity of performance to changes in physics assumptions are presented for the ITER-EDA Interim Design. The overall ITER device parameters have been derived from the performance goals using physics guidelines based on the physics R ampersand D results. The ITER-EDA design has a single-null divertor configuration (divertor at the bottom) with a nominal plasma current of 21 MA, magnetic field of 5.68 T, major and minor radius of 8.14 m and 2.8 m, and a plasma elongation (at the 95% flux surface) of ∼1.6 that produces a nominal fusion power of ∼1.5 GW for an ignited burn pulse length of ≥1000 s. The assessments have shown that ignition at 1.5 GW of fusion power can be sustained in ITER for 1000 s given present extrapolations of H-mode confinement (τ E = 0.85 x τ ITER93H ), helium exhaust (τ* He /τ E = 10), representative plasma impurities (n Be /n e = 2%), and beta limit [β N = β(%)/(I/aB) ≤ 2.5]. The provision of 100 MW of auxiliary power, necessary to access to H-mode during the approach to ignition, provides for the possibility of driven burn operations at Q = 15. This enables ITER to fulfill its mission of fusion power (∼ 1--1.5 GW) and fluence (∼1 MWa/m 2 ) goals if confinement, impurity levels, or operational (density, beta) limits prove to be less favorable than present projections. The power threshold for H-L transition, confinement uncertainties, and operational limits (Greenwald density limit and beta limit) are potential performance limiting issues. Improvement of the helium exhaust (τ* He /τ E ≤ 5) and potential operation in reverse-shear mode significantly improve ITER performance

  10. Designing nanoconjugates to effectively target pancreatic cancer cells in vitro and in vivo.

    Directory of Open Access Journals (Sweden)

    Jameel Ahmad Khan

    Full Text Available Pancreatic cancer is the fourth leading cause of cancer related deaths in America. Monoclonal antibodies are a viable treatment option for inhibiting cancer growth. Tumor specific drug delivery could be achieved utilizing these monoclonal antibodies as targeting agents. This type of designer therapeutic is evolving and with the use of gold nanoparticles it is a promising approach to selectively deliver chemotherapeutics to malignant cells. Gold nanoparticles (GNPs are showing extreme promise in current medicinal research. GNPs have been shown to non-invasively kill tumor cells by hyperthermia using radiofrequency. They have also been implemented as early detection agents due to their unique X-ray contrast properties; success was revealed with clear delineation of blood capillaries in a preclinical model by CT (computer tomography. The fundamental parameters for intelligent design of nanoconjugates are on the forefront. The goal of this study is to define the necessary design parameters to successfully target pancreatic cancer cells.The nanoconjugates described in this study were characterized with various physico-chemical techniques. We demonstrate that the number of cetuximab molecules (targeting agent on a GNP, the hydrodynamic size of the nanoconjugates, available reactive surface area and the ability of the nanoconjugates to sequester EGFR (epidermal growth factor receptor, all play critical roles in effectively targeting tumor cells in vitro and in vivo in an orthotopic model of pancreatic cancer.Our results suggest the specific targeting of tumor cells depends on a number of crucial components 1 targeting agent to nanoparticle ratio 2 availability of reactive surface area on the nanoparticle 3 ability of the nanoconjugate to bind the target and 4 hydrodynamic diameter of the nanoconjugate. We believe this study will help define the design parameters for formulating better strategies for specifically targeting tumors with nanoparticle

  11. Incorporating functional requirements into the structural design of the Defense Waste Processing Facility

    International Nuclear Information System (INIS)

    Hsiu, F.J.; Ng, C.K.; Almuti, A.M.

    1986-01-01

    Vitrification Building-type structures have unique features and design needs. The structural design requires new concepts and custom detailing. The above special structural designs have demonstrated the importance of the five design considerations listed in the introduction. Innovative ideas and close coordination are required to achieve the design objectives. Many of these innovations have been applied to the DWPF facility which is a first of a kind

  12. An Analysis of BIM Web Service Requirements and Design to Support Energy Efficient Building Lifecycle

    Directory of Open Access Journals (Sweden)

    Yufei Jiang

    2016-04-01

    Full Text Available Energy Efficient Building (EEB design, construction, and operations require the development and sharing of building information among different individuals, organizations, and computer applications. The Representational State Transfer (RESTful Building Information Modeling (BIM web service is a solution to enable an effective exchange of data. This paper presents an investigation into the core RESTful web service requirements needed to effectively support the EEB project lifecycle. The requirements include information exchange requirements, distributed collaboration requirements, internal data storage requirements, and partial model query requirements. We also propose a RESTful web service design model on different abstraction layers to enhance the BIM lifecycle in energy efficient building design. We have implemented a RESTful Application Program Interface (API prototype on a mock BIMserver to demonstrate our idea. We evaluate our design by conducting a user study based on the Technology Acceptance Model (TAM. The results show that our design can enhance the efficiency of data exchange in EEB design scenarios.

  13. Requirements and design structure for Surya Satellite-1

    Science.gov (United States)

    Steven, H.; Huzain, M. F.

    2018-05-01

    Currently, there are various references on the manufacture of nanosatellite specifications weighing 1KG - 10KG.The Surya Satellite-1 is the first nanosatellite made by universities in Indonesia. The Surya Satellite-1 team gets a launch offer from Japan Aerospace Exploration Agency (JAXA) and, all the nanosatellites manufacturer racers at ICD (Interface Control Document) obtained from JAXA. The formation of the Satellite-1 Surya framework is also based on the provisions of JAXA. The various specifications and requirements specified by the JAXA space agency consisting of specific specifications such as the mass of nanosatellite 1U (10cm x 10cm x 11.65cm) size of at least 0.13KG and a maximum of 1.33KG, with the determination of a gravity point not exceeding 2 cm from the nanosatellite geometry center point. In the case of preventing solar radiation in space, there is a requirement that the structure of satellite structures on hard black anodization should be more than 10 meters in the surface of the satellite structure. In terms of detail, the satellite structure is a black hard anodized aluminum after its manufacturing process derived from the MIL-A-8625 document, type 3.

  14. Long-rod projectiles against oblique targets: analysis and design recommendations

    International Nuclear Information System (INIS)

    Norris, D.M.; McMaster, W.H.; Wilkins, M.L.

    1976-01-01

    Computer calculations provide an understanding of impact phenomena associated with long rod penetrators striking targets at oblique angles. The rod and target material behaviors are described by elastic-plastic work-hardening constitutive models. Ductile fracture is simulated by setting all tensile and shear stresses to zero when the calculated plastic deformation reaches a critical value. The important penetration material properties to defeat a given target are identified. There is no single material property of overriding importance; a combination of properties is required for an efficient penetrator. Experimental results are presented to demonstrate the effects of ductility and toughness on penetration performance. Recommendations for possible improvement are suggested

  15. Data driven polypharmacological drug design for lung cancer: analyses for targeting ALK, MET, and EGFR

    DEFF Research Database (Denmark)

    Narayanan, Dilip; Gani, Osman ABSM; Gruber, Franz XE

    2017-01-01

    encoded into molecular mechanics force fields. Cheminformatics analyses of binding data show EGFR to be dissimilar to ALK and MET, but its structure shows how it may be co-targeted with the addition of a covalent trap. This suggests a strategy for the design of a focussed chemical library based on a pan......Drug design of protein kinase inhibitors is now greatly enabled by thousands of publicly available X-ray structures, extensive ligand binding data, and optimized scaffolds coming off patent. The extensive data begin to enable design against a spectrum of targets (polypharmacology); however...... consider polypharmacological targeting of protein kinases ALK, MET, and EGFR (and its drug resistant mutant T790M) in non small cell lung cancer as an example. Both EGFR and ALK represent sources of primary oncogenic lesions, while drug resistance arises from MET amplification and EGFR mutation. A drug...

  16. Methods to enable the design of bioactive small molecules targeting RNA.

    Science.gov (United States)

    Disney, Matthew D; Yildirim, Ilyas; Childs-Disney, Jessica L

    2014-02-21

    RNA is an immensely important target for small molecule therapeutics or chemical probes of function. However, methods that identify, annotate, and optimize RNA-small molecule interactions that could enable the design of compounds that modulate RNA function are in their infancies. This review describes recent approaches that have been developed to understand and optimize RNA motif-small molecule interactions, including structure-activity relationships through sequencing (StARTS), quantitative structure-activity relationships (QSAR), chemical similarity searching, structure-based design and docking, and molecular dynamics (MD) simulations. Case studies described include the design of small molecules targeting RNA expansions, the bacterial A-site, viral RNAs, and telomerase RNA. These approaches can be combined to afford a synergistic method to exploit the myriad of RNA targets in the transcriptome.

  17. Analysis of regulatory requirement for beyond design basis events of SMART

    International Nuclear Information System (INIS)

    Kim, W. S.; Seol, K. W.

    2000-01-01

    To enhance the safety of SMART reactor, safety and regulatory requirements associated with beyond design basis events (beyond BDE), which were developed and applied to advanced light water reactor designs, were analyzed along with a design status of passive reactor. And, based on these requirements, their applicability on the SMART design was evaluated. In the design aspect, severe accident prevention and mitigation features, containment performance, and accident management were analyzed. The evaluation results show that the requirement related to beyond DBE such as ATWS, loss of residual heat removal during shutdown operation, station blackout, fire, inter-system LOCA, and well-known events from severe accident phenomena is applicable to the SMART design. However, comprehensive approach against beyond DBE is not yet provided in the SMART design, and then it is required to designate and analyze the beyond DBE-related features. This study is expected to contribute to efforts to improve plant safety and to establish regulatory requirements for safety review

  18. Designing and modeling a centrifugal microfluidic device to separate target blood cells

    International Nuclear Information System (INIS)

    Shamloo, Amir; Selahi, AmirAli; Madadelahi, Masoud

    2016-01-01

    The objective of this study is to design a novel and efficient portable lab-on-a-CD (LOCD) microfluidic device for separation of specific cells (target cells) using magnetic beads. In this study the results are shown for neutrophils as target cells. However, other kinds of target cells can be separated in a similar approach. The designed microfluidics can be utilized as a point of care system for neutrophil detection. This microfluidic system employs centrifugal and magnetic forces for separation. After model validation by the experimental data in the literature (that may be used as a design tool for developing centrifugo-magnetophoretic devices), two models are presented for separation of target cells using magnetic beads. The first model consists of one container in the inlet section and two containers in the outlets. Initially, the inlet container is filled with diluted blood sample which is a mixture of red blood cells (RBCs) plus neutrophils which are attached to Magnetic beads. It is shown that by using centrifugal and magnetic forces, this model can separate all neutrophils with recovery factor of ∼100%. In the second model, due to excess of magnetic beads in usual experimental analysis (to ensure that all target cells are attached to them) the geometry is improved by adding a third outlet for these free magnetic beads. It is shown that at angular velocity of 45 rad s −1 , recovery factor of 100% is achievable for RBCs, free magnetic beads and neutrophils as target cells. (paper)

  19. Designing and modeling a centrifugal microfluidic device to separate target blood cells

    Science.gov (United States)

    Shamloo, Amir; Selahi, AmirAli; Madadelahi, Masoud

    2016-03-01

    The objective of this study is to design a novel and efficient portable lab-on-a-CD (LOCD) microfluidic device for separation of specific cells (target cells) using magnetic beads. In this study the results are shown for neutrophils as target cells. However, other kinds of target cells can be separated in a similar approach. The designed microfluidics can be utilized as a point of care system for neutrophil detection. This microfluidic system employs centrifugal and magnetic forces for separation. After model validation by the experimental data in the literature (that may be used as a design tool for developing centrifugo-magnetophoretic devices), two models are presented for separation of target cells using magnetic beads. The first model consists of one container in the inlet section and two containers in the outlets. Initially, the inlet container is filled with diluted blood sample which is a mixture of red blood cells (RBCs) plus neutrophils which are attached to Magnetic beads. It is shown that by using centrifugal and magnetic forces, this model can separate all neutrophils with recovery factor of ~100%. In the second model, due to excess of magnetic beads in usual experimental analysis (to ensure that all target cells are attached to them) the geometry is improved by adding a third outlet for these free magnetic beads. It is shown that at angular velocity of 45 rad s-1, recovery factor of 100% is achievable for RBCs, free magnetic beads and neutrophils as target cells.

  20. Characterisation of target plasma required for REB-plasma interaction studies using cylindrical Langmuir probes

    International Nuclear Information System (INIS)

    Roychowdhury, P.; Paithankar, A.S.; Iyyengar, S.K.; Rohatgi, V.K.

    1987-01-01

    The target plasma required for relativistic electron beam (REB)-plasma interaction studies has been generated by coaxial plasma gun. The measurement of electron density and temperature has been carried out using cylindrical Langmuir probes. Probes both oriented parallel and transverse to the flow have been used. The spatial as well as temporal variation of electron density and temperature have been studied. The typical electron density and temperature measured by probe were in the range of 9.0-3.5 x 10 13 cm -3 and 5-7 eV respectively. The typical e-folding decay time of density was 6.2 μs, while no appreciable change in electron temperature was observed until 10 μs after the peak density. The density decays by about 50% at distance of 30 cm from the gun. The plasma flow velocity has been measured by the time of flight technique and was found to be 2.5 x 10 6 cm s -1 . The plasma radius measured by dosimeter film, at distance of 30 cm from the gun was 3 cm. (author)

  1. Design and Certification of Targets for Drop Tests at the NTRC Packaging Research Facility

    International Nuclear Information System (INIS)

    Ludwig, S.B.

    2003-01-01

    This report provides documentation of the design and certification of drop pad (targets) at the National Transportation Research Center (NTRC) Packaging Research Facility(PRF). Based on the evaluation performed, it has been demonstrated that the small (interior) drop pad (target) meets the regulatory definition of a flat, essentially unyielding, horizontal surface for packages weighing up to 3,150 lb (1,432 kg). The large (exterior) drop pad (target) meets the regulatory definition of a flat, essentially unyielding, horizontal surface for packages weighing up to 28,184 lb (12,811 kg)

  2. Design and fabrication of foam-insulated cryogenic target for wet-wall laser fusion reactor

    International Nuclear Information System (INIS)

    Norimatsu, T.; Takeda, T.; Nagai, K.; Mima, K.; Yamanaka, T.

    2003-01-01

    A foam insulated cryogenic target was proposed for use in a future laser fusion reactor with a wet wall. This scheme can protect the solid DT layer from melting due to surface heating by adsorption of metal vapor without significant reduction in the target gain. Design spaces for the injection velocity and the acceptable vapor pressure in the reactor are discussed. Basic technology to fabricate such structure was demonstrated by emulsion process. Concept of a cryogenic fast-ignition target with a gold guiding cone was proposed together with direct injection filling of liquid DT. (author)

  3. EURISOL-DS Overall Design of the Multi-MW Target Station

    CERN Document Server

    Olivier Choisnet, Cyril Kharoua, Yacine Kadi, Karel Samec (CERN)

    The EURISOL Design Study investigated the feasibility of a complex instrument to push back the boundaries of current physics knowledge amidst today’s ever-increasing need for realism due to constraints imposed by safety, performance and, not least, budgetary responsibility.In order to attend to these concerns, the EURISOL Multi-Megawatt converter target, its associated fission targets and the three 100 kW direct targets are all integrated into a single facility housing the ancillary equipment as well. The overall layout of the facility, its functional break-down and the main modes of operation are presented in the current report.

  4. Targeting Allostery with Avatars to Design Inhibitors Assessed by Cell Activity: Dissecting MRE11 Endo- and Exonuclease Activities.

    Science.gov (United States)

    Moiani, Davide; Ronato, Daryl A; Brosey, Chris A; Arvai, Andrew S; Syed, Aleem; Masson, Jean-Yves; Petricci, Elena; Tainer, John A

    2018-01-01

    For inhibitor design, as in most research, the best system is question dependent. We suggest structurally defined allostery to design specific inhibitors that target regions beyond active sites. We choose systems allowing efficient quality structures with conformational changes as optimal for structure-based design to optimize inhibitors. We maintain that evolutionarily related targets logically provide molecular avatars, where this Sanskrit term for descent includes ideas of functional relationships and of being a physical embodiment of the target's essential features without requiring high sequence identity. Appropriate biochemical and cell assays provide quantitative measurements, and for biomedical impacts, any inhibitor's activity should be validated in human cells. Specificity is effectively shown empirically by testing if mutations blocking target activity remove cellular inhibitor impact. We propose this approach to be superior to experiments testing for lack of cross-reactivity among possible related enzymes, which is a challenging negative experiment. As an exemplary avatar system for protein and DNA allosteric conformational controls, we focus here on developing separation-of-function inhibitors for meiotic recombination 11 nuclease activities. This was achieved not by targeting the active site but rather by geometrically impacting loop motifs analogously to ribosome antibiotics. These loops are neighboring the dimer interface and active site act in sculpting dsDNA and ssDNA into catalytically competent complexes. One of our design constraints is to preserve DNA substrate binding to geometrically block competing enzymes and pathways from the damaged site. We validate our allosteric approach to controlling outcomes in human cells by reversing the radiation sensitivity and genomic instability in BRCA mutant cells. © 2018 Elsevier Inc. All rights reserved.

  5. National Ignition Facility sub-system design requirements computer system SSDR 1.5.1

    International Nuclear Information System (INIS)

    Spann, J.; VanArsdall, P.; Bliss, E.

    1996-01-01

    This System Design Requirement document establishes the performance, design, development and test requirements for the Computer System, WBS 1.5.1 which is part of the NIF Integrated Computer Control System (ICCS). This document responds directly to the requirements detailed in ICCS (WBS 1.5) which is the document directly above

  6. National Ignition Facility subsystem design requirements supervisory control software SSDR 1.5.2

    International Nuclear Information System (INIS)

    Woodruff, J.; VanArsdall, P.; Bliss, E.

    1996-01-01

    This System Design Requirement document establishes the performance, design, development, and test requirements for the Supervisory Control Software, WBS 1.5.2, which is part of the NIF Integrated Computer Control System (ICCS). This document responds directly to the requirements detailed in ICCS (WBS 1-5)

  7. Regulatory requirements for designing PET-CT facility in India

    International Nuclear Information System (INIS)

    Tandon, Pankaj

    2010-01-01

    In India, cyclotron-produced radionuclides are gaining importance in molecular imaging in Nuclear Medicine (NM) departments. The importance of this modality among others is due to the fact that it provides valuable clinical information, which was lacking in other available modalities. Presently, every well-established hospital would like to procure Medical Cyclotron or positron emission tomography-computed tomography (PET-CT) facility in their NM department. Because cyclotron-produced radionuclides have higher energy than the other routinely used radionuclides for diagnosis, it becomes essential for the user to know about the regulatory requirement and radiation safety precautions that one has to take for the installation of this new modality in their premises. The various stages of approval of PET-CT facility by the Atomic Energy Regulatory Board (AERB) and important steps that one has to know/follow before planning for this new facility are summarized

  8. Shielding design for the target room of the proton accelerator research center

    International Nuclear Information System (INIS)

    Min, Y. S.; Lee, C. W.; Mun, K. J.; Nam, J.; Kim, J. Y.

    2010-01-01

    The Proton Engineering Frontier Project (PEFP) has been developing a 100-MeV proton linear accelerator. Also, PEFP has been designing the Proton Accelerator Research Center (PARC). In the Accelerator Tunnel and Beam Experiment Hall in PARC, 10 target rooms for the 20- and 100-MeV beamline facilities exist in the Beam Experiment Hall. For the 100-MeV target rooms during 100-MeV proton beam extraction, a number of high energy neutrons, ranging up to 100-MeV, are produced. Because of the high beam current and space limitations of each target room, the shielding design of each target room should be considered seriously. For the shielding design of the 100-MeV target rooms of the PEFP, a permanent and removable local shield structure was adopted. To optimize shielding performance, we evaluated four different shield materials (concrete, HDPE, lead, iron). From the shielding calculation results, we confirmed that the proposed shielding design made it possible to keep the dose rate below the 'as low as reasonably achievable (ALARA)' objective.

  9. Ligand design for riboswitches, an emerging target class for novel antibiotics.

    Science.gov (United States)

    Rekand, Illimar Hugo; Brenk, Ruth

    2017-09-01

    Riboswitches are cis-acting gene regulatory elements and constitute potential targets for new antibiotics. Recent studies in this field have started to explore these targets for drug discovery. New ligands found by fragment screening, design of analogs of the natural ligands or serendipitously by phenotypic screening have shown antibacterial effects in cell assays against a range of bacteria strains and in animal models. In this review, we highlight the most advanced drug design work of riboswitch ligands and discuss the challenges in the field with respect to the development of antibiotics with a new mechanism of action.

  10. An overview of some basic design features of Koeberg Nuclear Power Station highlighting how regulatory requirements can influence design

    International Nuclear Information System (INIS)

    Morrison, A.R.

    1985-01-01

    The paper attempts to show that licensing requirements significantly influence the design of nuclear power plants. The French designed Pressurised Water Reactor system adopted by Escom at Koeberg has its origins in the General Design Criteria set out in the American Code of Federal Regulations document 10CFR50. Three of the General Design Criteria have been selected for illustrating how the requirements have influenced Koeberg in terms of design, both from a hardware and software view point. The requirements of the criteria on quality standard and records are to a certain extent reflected in the Licensing Branch Guide developed by the Atomic Energy Corporation to address quality assurance. The criterion on containment design sets requirements in respect of containment design which are incorporated in the Koeberg design. The criterion on electric power systems sets many of the basic design requirements for the electrical power supply systems inside and outside the station. The existence of the criterion led Escom to introduce changes in the transmission network to meet the requirements in respect of the independent criteria for the grid connections

  11. Design and Demonstration of a Material-Plasma Exposure Target Station for Neutron Irradiated Samples

    Energy Technology Data Exchange (ETDEWEB)

    Rapp, Juergen [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Aaron, A. M. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Bell, Gary L. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Burgess, Thomas W. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Ellis, Ronald James [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Giuliano, D. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Howard, R. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Kiggans, James O. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Lessard, Timothy L. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Ohriner, Evan Keith [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Perkins, Dale E. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Varma, Venugopal Koikal [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2015-10-20

    Fusion energy is the most promising energy source for the future, and one of the most important problems to be solved progressing to a commercial fusion reactor is the identification of plasma-facing materials compatible with the extreme conditions in the fusion reactor environment. The development of plasma–material interaction (PMI) science and the technology of plasma-facing components are key elements in the development of the next step fusion device in the United States, the so-called Fusion Nuclear Science Facility (FNSF). All of these PMI issues and the uncertain impact of the 14-MeV neutron irradiation have been identified in numerous expert panel reports to the fusion community. The 2007 Greenwald report classifies reactor plasma-facing materials (PFCs) and materials as the only Tier 1 issues, requiring a “. . . major extrapolation from the current state of knowledge, need for qualitative improvements and substantial development for both the short and long term.” The Greenwald report goes on to list 19 gaps in understanding and performance related to the plasma–material interface for the technology facilities needed for DEMO-oriented R&D and DEMO itself. Of the 15 major gaps, six (G7, G9, G10, G12, G13) can possibly be addressed with ORNL’s proposal of an advanced Material Plasma Exposure eXperiment. Establishing this mid-scale plasma materials test facility at ORNL is a key element in ORNL’s strategy to secure a leadership role for decades of fusion R&D. That is to say, our end goal is to bring the “signature facility” FNSF home to ORNL. This project is related to the pre-conceptual design of an innovative target station for a future Material–Plasma Exposure eXperiment (MPEX). The target station will be designed to expose candidate fusion reactor plasma-facing materials and components (PFMs and PFCs) to conditions anticipated in fusion reactors, where PFCs will be exposed to dense high-temperature hydrogen plasmas providing steady

  12. Design and Demonstration of a Material-Plasma Exposure Target Station for Neutron Irradiated Samples

    International Nuclear Information System (INIS)

    Rapp, Juergen; Aaron, A. M.; Bell, Gary L.; Burgess, Thomas W.; Ellis, Ronald James; Giuliano, D.; Howard, R.; Kiggans, James O.; Lessard, Timothy L.; Ohriner, Evan Keith; Perkins, Dale E.; Varma, Venugopal Koikal

    2015-01-01

    Fusion energy is the most promising energy source for the future, and one of the most important problems to be solved progressing to a commercial fusion reactor is the identification of plasma-facing materials compatible with the extreme conditions in the fusion reactor environment. The development of plasma-material interaction (PMI) science and the technology of plasma-facing components are key elements in the development of the next step fusion device in the United States, the so-called Fusion Nuclear Science Facility (FNSF). All of these PMI issues and the uncertain impact of the 14-MeV neutron irradiation have been identified in numerous expert panel reports to the fusion community. The 2007 Greenwald report classifies reactor plasma-facing materials (PFCs) and materials as the only Tier 1 issues, requiring a ''. . . major extrapolation from the current state of knowledge, need for qualitative improvements and substantial development for both the short and long term.'' The Greenwald report goes on to list 19 gaps in understanding and performance related to the plasma-material interface for the technology facilities needed for DEMO-oriented R&D and DEMO itself. Of the 15 major gaps, six (G7, G9, G10, G12, G13) can possibly be addressed with ORNL's proposal of an advanced Material Plasma Exposure eXperiment. Establishing this mid-scale plasma materials test facility at ORNL is a key element in ORNL's strategy to secure a leadership role for decades of fusion R&D. That is to say, our end goal is to bring the ''signature facility'' FNSF home to ORNL. This project is related to the pre-conceptual design of an innovative target station for a future Material-Plasma Exposure eXperiment (MPEX). The target station will be designed to expose candidate fusion reactor plasma-facing materials and components (PFMs and PFCs) to conditions anticipated in fusion reactors, where PFCs will be exposed to dense high-temperature hydrogen plasmas providing steady-state heat fluxes of

  13. Conceptual Biorefinery Design and Research Targeted for 2022: Hydrothermal Liquefacation Processing of Wet Waste to Fuels

    Energy Technology Data Exchange (ETDEWEB)

    Snowden-Swan, Lesley J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Zhu, Yunhua [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Bearden, Mark D. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Seiple, Timothy E. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Jones, Susanne B. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Schmidt, Andrew J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Billing, Justin M. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Hallen, Richard T. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Hart, Todd R. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Liu, Jian [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Albrecht, Karl O. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Fox, Samuel P. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Maupin, Gary D. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Elliott, Douglas C. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2017-12-28

    represents a goal case for the pathway, targeting performance that is anticipated to be achievable by 2022 with further research and development. The year 2022 is BETO’s target year for verification of hydrocarbon biofuel pathways. As this analysis represents a goal case, assumed values of several design parameters represent improvements in the technology relative to what has currently been demonstrated in the laboratory. While HTL is fairly well developed and may therefore be ready for commercialization prior to 2022, there are specific advancements addressed in this analysis that are necessary to enhance performance compared to what has been demonstrated to date. In addition, an important aspect to the pathway is the upgrading of biocrude to fuel blendstock, an area that has received much less attention and requires significant research to validate the goal case performance parameters. The estimated plant gate minimum fuel selling price for fuel blendstock from sludge HTL and upgrading is $3.46/gasoline gallon equivalent (gge). This price is within the tolerance (+$0.49/gge) of BETO’s $3/gge programmatic cost target and illustrates that fuel blendstocks generated from HTL of sludge and centralized biocrude upgrading have the potential to be competitive with fossil fuels. This analysis illustrates the feasibility of HTL for point-of-generation conversion of waste feedstock at a scale 1/20th that of the standard lignocellulosic biorefinery scale typically used in BETO design cases. The relevance of this work reaches beyond wastewater treatment sludge to lay the groundwork for application to other distributed wet wastes and blends that together represent a significant resource of underutilized biomass.

  14. Design requirements for SRB production control system. Volume 2: System requirements and conceptual description

    Science.gov (United States)

    1981-01-01

    In the development of the business system for the SRB automated production control system, special attention had to be paid to the unique environment posed by the space shuttle. The issues posed by this environment, and the means by which they were addressed, are reviewed. The change in management philosphy which will be required as NASA switches from one-of-a-kind launches to multiple launches is discussed. The implications of the assembly process on the business system are described. These issues include multiple missions, multiple locations and facilities, maintenance and refurbishment, multiple sources, and multiple contractors. The implications of these aspects on the automated production control system are reviewed including an assessment of the six major subsystems, as well as four other subsystem. Some general system requirements which flow through the entire business system are described.

  15. Requirements on PWR reactor design with respect to seismic effects

    International Nuclear Information System (INIS)

    Novak, J.; Pecinka, L.

    1981-01-01

    From the seismic point of view the individual parts of a nuclear power plant must be built such as to allow the shutdown of the reactor up to the safe shutdown earthquake level, the removal of after-heat and the prevention of uncontrolled release of radioactivity into the environment. To the level of operating basic earthquake the plant must be designed such as to allow the operation of the reactor for a period of 100 hours from the seismic event without exceeding the permissible annual dose to personnel and population. The possibility of a loss-of-coolant accident owing to a seismic event is reduced mainly by the integrated performance of the primary circuit, the high-strength structure, the insulation of the main components from the shift of the foundations and the use of floating structures. The pressure vessel of the WWER-1000 reactor is therefore pAaced in a shaft on a support ring and is locked by another support ring. (Z.M.)

  16. Evaluating the Impact of Design-Driven Requirements Using SysML

    Data.gov (United States)

    National Aeronautics and Space Administration — The proposed research will develop SysML requirements modeling patterns and scripts to automate the evaluation of the impact of design driven requirements....

  17. The Knowledge Wall for the Global 2000 War Game: Design Solutions to Match JOC User Requirements

    National Research Council Canada - National Science Library

    Smallman, H

    2001-01-01

    ...) for the Global 2000 War Game. What features and content should this new display possess? This report presents a Knowledge Wall design capable of meeting these requirements and elaborates its design features from the 'ground...

  18. Targeting a heterologous protein to multiple plant organelles via rationally designed 5? mRNA tags

    NARCIS (Netherlands)

    Voges, M.J.; Silver, P.A.; Way, J.C.; Mattozzi, M.D.

    2013-01-01

    Background Plant bioengineers require simple genetic devices for predictable localization of heterologous proteins to multiple subcellular compartments. Results We designed novel hybrid signal sequences for multiple-compartment localization and characterize their function when fused to GFP in

  19. Functional analysis of TMLH variants and definition of domains required for catalytic activity and mitochondrial targeting.

    Science.gov (United States)

    Monfregola, Jlenia; Cevenini, Armando; Terracciano, Antonio; van Vlies, Naomi; Arbucci, Salvatore; Wanders, Ronald J A; D'Urso, Michele; Vaz, Frédéric M; Ursini, Matilde Valeria

    2005-09-01

    epsilon-N-Trimethyllysine hydroxylase (TMLH) (EC 1.14.11.8) is a non-heme-ferrous iron hydroxylase, Fe(++) and 2-oxoglutarate (2OG) dependent, catalyzing the first of four enzymatic reactions of the highly conserved carnitine biosynthetic pathway. Otherwise from all the other enzymes of carnitine biosynthesis, TMLH was found to be associated to the mitochondrial fraction. We here report molecular cloning of two alternative spliced forms of TMLH, which appear ubiquitously expressed in human adult and fetal tissues. The deduced proteins are designated TMLH-a and TMLH-b, and contain 421 and 399 amino acids, respectively. They share the first N-terminal 332 amino acids, including a mitochondrial targeting signal, but diverge at the C-terminal end. TMLH-a and TMLH-b exogenous expression in COS-1 cells shows that the first 15 amino acids are necessary and sufficient for mitochondrial import. Furthermore, comparative evolutionary analysis of the C-terminal portion of TMLH-a identifies a conserved domain characterized by a key triad of residues, His242-Glu244-His389 predicted to bind 2OG end. This sequence is conserved in the TMLH enzyme from all species but is partially substituted by a unique sequence in the TMLH-b variant. Indeed, TMLH-b is not functional by itself as well as a TMLH-H389L mutant produced by site directed mutagenesis. As great interest, we found that TMLH-b and TMLH-H389L, individually co-expressed with TMLH-a in COS-1 cells, negatively affect TMLH activity. Therefore, our studies on the TMLH alternative form provide relevant novel information, first that the C-terminal region of TMLH contains the main determinants for its enzymatic activity including a key H389 residue, and second that TMLH-b could act as a crucial physiological negative regulator of TMLH. Copyright 2005 Wiley-Liss, Inc.

  20. Reduced cost design of liquid lithium target for international fusion material irradiation facility (IFMIF)

    International Nuclear Information System (INIS)

    Nakamura, Hiroo; Ida, Mizuho; Sugimoto, Masayoshi; Takeuchi, Hiroshi; Yutani, Toshiaki

    2001-01-01

    The International Fusion Materials Irradiation Facility (IFMIF) is being jointly planned to provide an accelerator-based D-Li neutron source to produce intense high energy neutrons (2 MW/m 2 ) up to 200 dpa and a sufficient irradiation volume (500 cm 3 ) for testing the candidate materials and components up to about a full lifetime of their anticipated use in ITER and DEMO. To realize such a condition, 40 MeV deuteron beam with a current of 250 mA is injected into high speed liquid lithium flow with a speed of 20 m/s. Following Conceptual Design Activity (1995-1998), a design study with focus on cost reduction without changing its original mission has been done in 1999. The following major changes to the CAD target design have been considered in the study and included in the new design: i) number of the Li target has been changed from 2 to 1, ii) spare of impurity traps of the Li loop was removed although the spare will be stored in a laboratory for quick exchange, iii) building volume was reduced via design changes in lithium loop length. This paper describes the reduced cost design of the lithium target system and recent status of Key Element Technology activities. (author)

  1. Target/blanket conceptual design for the Los Alamos ATW concept

    International Nuclear Information System (INIS)

    Ames, K.; Cappiello, M.; Ireland, J.; Sapir, J.; Farnum, G.

    1992-01-01

    The Los Alamos Accelerator Transmutation of Waste (ATW) concept has many potential applications that include defense waste transmutation, defense material production (i.e., tritium and 238 Pu), and the transmutation of hazardous nuclear wastes from commercial nuclear reactors (fission products and actinides). A more advanced long-term Los Alamos effort is investigating the potential of an accelerator- driven system to produce fission energy with a minimal nuclear waste stream. All applications employ a high-energy (800- to 1600-MeV), high-current (25--250 mA) proton linear accelerator as the driver. In this report, we discuss only the target/blanket conceptual design for the commercial nuclear waste application. A conceptual design for the target/blanket of the Los Alamos ATW concept has been presented. The neutronics, mechanical design, and heat transfer have been investigated in some detail for the base-case design. Much more work needs to be done, but at this point it appears that the design is feasible and will approach the design goal of supporting two commercial power reactors with each target/blanket module

  2. Experimental study of lithium free-surface flow for IFMIF target design

    International Nuclear Information System (INIS)

    Kondo, H.; Fujisato, A.; Yamaoka, N.; Inoue, S.; Miyamoto, S.; Iida, T.; Nakamura, H.; Ida, M.; Matushita, I.; Muroga, T.; Horiike, H.

    2006-01-01

    Lithium free-surface flow experiments to verify the design of IFMIF target have been carried out at Osaka University. The present report summarizes experimental results of surface phenomena, and cavitation characteristics of the loop, so as to try to apply these results to design parameters. Waves on the lithium flow surface is similar to that on water, and can be predicted by a linear stability theory. The wave amplitude is measured by an electro-contact probe. Surface roughness on a target nozzle, caused for example by attached chemical compounds and/or wastages by erosion and corrosion, can lead to a significant loss of target flow stability as well as surface wakes. The need of a polishing manipulator or exchange of the nozzle may be anticipated. Cavitation characteristic of the loop was measured by an accelerometer. From the results, a friction factor could be estimated fort he lithium flow

  3. EDRP public local inquiry, UKAEA/BNFL precognition on: Risk targets and EDRP design

    International Nuclear Information System (INIS)

    Brown, M.L.

    1986-06-01

    A full description is presented of the extent to which risk is controlled by the targets to be implemented in the proposed EDRP design, including a discussion of a particular accident sequence. Risk expressions and the usefulness of risk criteria are reviewed. Details are given of the accident consequence modelling as used by the UKAEA. Terrorist attack and sabotage are briefly discussed. (UK)

  4. Design of block-copolymer-based micelles for active and passive targeting

    NARCIS (Netherlands)

    Lebouille, Jérôme G J L; Leermakers, Frans A M; Cohen Stuart, Martien A.; Tuinier, Remco

    2016-01-01

    A self-consistent field study is presented on the design of active and passive targeting block-copolymeric micelles. These micelles form in water by self-assembly of triblock copolymers with a hydrophilic middle block and two hydrophobic outer blocks. A minority amount of diblock copolymers with the

  5. Design of block-copolymer-based micelles for active and passive targeting

    NARCIS (Netherlands)

    Lebouille, Jérôme G.J.L.; Leermakers, Frans A.M.; Cohen Stuart, Martien A.; Tuinier, Remco

    2016-01-01

    A self-consistent field study is presented on the design of active and passive targeting block-copolymeric micelles. These micelles form in water by self-assembly of triblock copolymers with a hydrophilic middle block and two hydrophobic outer blocks. A minority amount of diblock copolymers with

  6. Safeguards Guidance Document for Designers of Commercial Nuclear Facilities: International Nuclear Safeguards Requirements and Practices For Uranium Enrichment Plants

    Energy Technology Data Exchange (ETDEWEB)

    Robert Bean; Casey Durst

    2009-10-01

    This report is the second in a series of guidelines on international safeguards requirements and practices, prepared expressly for the designers of nuclear facilities. The first document in this series is the description of generic international nuclear safeguards requirements pertaining to all types of facilities. These requirements should be understood and considered at the earliest stages of facility design as part of a new process called “Safeguards-by-Design.” This will help eliminate the costly retrofit of facilities that has occurred in the past to accommodate nuclear safeguards verification activities. The following summarizes the requirements for international nuclear safeguards implementation at enrichment plants, prepared under the Safeguards by Design project, and funded by the U.S. Department of Energy (DOE) National Nuclear Security Administration (NNSA), Office of NA-243. The purpose of this is to provide designers of nuclear facilities around the world with a simplified set of design requirements and the most common practices for meeting them. The foundation for these requirements is the international safeguards agreement between the country and the International Atomic Energy Agency (IAEA), pursuant to the Treaty on the Non-proliferation of Nuclear Weapons (NPT). Relevant safeguards requirements are also cited from the Safeguards Criteria for inspecting enrichment plants, found in the IAEA Safeguards Manual, Part SMC-8. IAEA definitions and terms are based on the IAEA Safeguards Glossary, published in 2002. The most current specification for safeguards measurement accuracy is found in the IAEA document STR-327, “International Target Values 2000 for Measurement Uncertainties in Safeguarding Nuclear Materials,” published in 2001. For this guide to be easier for the designer to use, the requirements have been restated in plainer language per expert interpretation using the source documents noted. The safeguards agreement is fundamentally a

  7. Breaking camouflage and detecting targets require optic flow and image structure information.

    Science.gov (United States)

    Pan, Jing Samantha; Bingham, Ned; Chen, Chang; Bingham, Geoffrey P

    2017-08-01

    Use of motion to break camouflage extends back to the Cambrian [In the Blink of an Eye: How Vision Sparked the Big Bang of Evolution (New York Basic Books, 2003)]. We investigated the ability to break camouflage and continue to see camouflaged targets after motion stops. This is crucial for the survival of hunting predators. With camouflage, visual targets and distracters cannot be distinguished using only static image structure (i.e., appearance). Motion generates another source of optical information, optic flow, which breaks camouflage and specifies target locations. Optic flow calibrates image structure with respect to spatial relations among targets and distracters, and calibrated image structure makes previously camouflaged targets perceptible in a temporally stable fashion after motion stops. We investigated this proposal using laboratory experiments and compared how many camouflaged targets were identified either with optic flow information alone or with combined optic flow and image structure information. Our results show that the combination of motion-generated optic flow and target-projected image structure information yielded efficient and stable perception of camouflaged targets.

  8. Shock ignition: a brief overview and progress in the design of robust targets

    International Nuclear Information System (INIS)

    Atzeni, S; Marocchino, A; Schiavi, A

    2015-01-01

    Shock ignition is a laser direct-drive inertial confinement fusion (ICF) scheme in which the stages of compression and hot spot formation are partly separated. The fuel is first imploded at a lower velocity than in conventional ICF, reducing the threats due to Rayleigh–Taylor instability. Close to stagnation, an intense laser spike drives a strong converging shock, which contributes to hot spot formation. This paper starts with a brief overview of the theoretical studies, target design and experimental results on shock ignition. The second part of the paper illustrates original work aiming at the design of robust targets and computation of the relevant gain curves. Following Chang et al (2010 Phys. Rev. Lett. 104 135002) a safety factor for high gain, ITF* (analogous to the ignition threshold factor ITF introduced by Clark et al (2008 Phys. Plasmas 15 056305)), is evaluated by means of parametric 1D simulations with artificially reduced reactivity. SI designs scaled as in Atzeni et al (2013 New J. Phys. 15 045004) are found to have nearly the same ITF*. For a given target, such ITF* increases with implosion velocity and laser spike power. A gain curve with a prescribed ITF* can then be simply generated by upscaling a reference target with that value of ITF*. An interesting option is scaling in size by reducing the implosion velocity to keep the ratio of implosion velocity to self-ignition velocity constant. At a given total laser energy, targets with higher ITF* are driven to higher implosion velocity and achieve a somewhat lower gain. However, a 1D gain higher than 100 is achieved at an (incident) energy below 1 MJ, an implosion velocity below 300 km s −1 and a peak incident power below 400 TW. 2D simulations of mispositioned targets show that targets with a higher ITF* indeed tolerate larger displacements. (paper)

  9. Safety of Nuclear Power Plants: Design. Specific Safety Requirements (Spanish Edition)

    International Nuclear Information System (INIS)

    2012-01-01

    This publication is a revision of Safety Requirements No. NS-R-1, Safety of Nuclear Power Plants: Design. It establishes requirements applicable to the design of nuclear power plants and elaborates on the safety objective, safety principles and concepts that provide the basis for deriving the safety requirements that must be met for the design of a nuclear power plant. It will be useful for organizations involved in the design, manufacture, construction, modification, maintenance, operation and decommissioning of nuclear power plants, as well as for regulatory bodies. Contents: 1. Introduction; 2. Applying the safety principles and concepts; 3. Management of safety in design; 4. Principal technical requirements; 5. General plant design; 6. Design of specific plant systems.

  10. Safety of Nuclear Power Plants: Design. Specific Safety Requirements (Russian Edition)

    International Nuclear Information System (INIS)

    2012-01-01

    This publication is a revision of Safety Requirements No. NS-R-1, Safety of Nuclear Power Plants: Design. It establishes requirements applicable to the design of nuclear power plants and elaborates on the safety objective, safety principles and concepts that provide the basis for deriving the safety requirements that must be met for the design of a nuclear power plant. It will be useful for organizations involved in the design, manufacture, construction, modification, maintenance, operation and decommissioning of nuclear power plants, as well as for regulatory bodies. Contents: 1. Introduction; 2. Applying the safety principles and concepts; 3. Management of safety in design; 4. Principal technical requirements; 5. General plant design; 6. Design of specific plant systems.

  11. Proton-beam window design for a transmutation facility operating with a liquid lead target

    Energy Technology Data Exchange (ETDEWEB)

    Jansen, C.; Lypsch, F.; Lizana, P. [Institute for Safety Research and Reactor Technology, Juelich (Germany)] [and others

    1995-10-01

    The proton beam target of an accelerator-driven transmutation facility can be designed as a vertical liquid lead column. To prevent lead vapor from entering the accelerator vacuum, a proton-beam window has to separate the area above the lead surface from the accelerator tube. Two radiation-cooled design alternatives have been investigated which should withstand a proton beam of 1.6 GeV and 25 mA. Temperature calculations based on energy deposition calculations with the Monte Carlo code HETC, stability analysis and spallation-induced damage calculations have been performed showing the applicability of both designs.

  12. Statistical inference on censored data for targeted clinical trials under enrichment design.

    Science.gov (United States)

    Chen, Chen-Fang; Lin, Jr-Rung; Liu, Jen-Pei

    2013-01-01

    For the traditional clinical trials, inclusion and exclusion criteria are usually based on some clinical endpoints; the genetic or genomic variability of the trial participants are not totally utilized in the criteria. After completion of the human genome project, the disease targets at the molecular level can be identified and can be utilized for the treatment of diseases. However, the accuracy of diagnostic devices for identification of such molecular targets is usually not perfect. Some of the patients enrolled in targeted clinical trials with a positive result for the molecular target might not have the specific molecular targets. As a result, the treatment effect may be underestimated in the patient population truly with the molecular target. To resolve this issue, under the exponential distribution, we develop inferential procedures for the treatment effects of the targeted drug based on the censored endpoints in the patients truly with the molecular targets. Under an enrichment design, we propose using the expectation-maximization algorithm in conjunction with the bootstrap technique to incorporate the inaccuracy of the diagnostic device for detection of the molecular targets on the inference of the treatment effects. A simulation study was conducted to empirically investigate the performance of the proposed methods. Simulation results demonstrate that under the exponential distribution, the proposed estimator is nearly unbiased with adequate precision, and the confidence interval can provide adequate coverage probability. In addition, the proposed testing procedure can adequately control the size with sufficient power. On the other hand, when the proportional hazard assumption is violated, additional simulation studies show that the type I error rate is not controlled at the nominal level and is an increasing function of the positive predictive value. A numerical example illustrates the proposed procedures. Copyright © 2013 John Wiley & Sons, Ltd.

  13. Mechanistic and quantitative insight into cell surface targeted molecular imaging agent design.

    Science.gov (United States)

    Zhang, Liang; Bhatnagar, Sumit; Deschenes, Emily; Thurber, Greg M

    2016-05-05

    Molecular imaging agent design involves simultaneously optimizing multiple probe properties. While several desired characteristics are straightforward, including high affinity and low non-specific background signal, in practice there are quantitative trade-offs between these properties. These include plasma clearance, where fast clearance lowers background signal but can reduce target uptake, and binding, where high affinity compounds sometimes suffer from lower stability or increased non-specific interactions. Further complicating probe development, many of the optimal parameters vary depending on both target tissue and imaging agent properties, making empirical approaches or previous experience difficult to translate. Here, we focus on low molecular weight compounds targeting extracellular receptors, which have some of the highest contrast values for imaging agents. We use a mechanistic approach to provide a quantitative framework for weighing trade-offs between molecules. Our results show that specific target uptake is well-described by quantitative simulations for a variety of targeting agents, whereas non-specific background signal is more difficult to predict. Two in vitro experimental methods for estimating background signal in vivo are compared - non-specific cellular uptake and plasma protein binding. Together, these data provide a quantitative method to guide probe design and focus animal work for more cost-effective and time-efficient development of molecular imaging agents.

  14. Recent Developments in the VISRAD 3-D Target Design and Radiation Simulation Code

    Science.gov (United States)

    Macfarlane, Joseph; Golovkin, Igor; Sebald, James

    2017-10-01

    The 3-D view factor code VISRAD is widely used in designing HEDP experiments at major laser and pulsed-power facilities, including NIF, OMEGA, OMEGA-EP, ORION, Z, and LMJ. It simulates target designs by generating a 3-D grid of surface elements, utilizing a variety of 3-D primitives and surface removal algorithms, and can be used to compute the radiation flux throughout the surface element grid by computing element-to-element view factors and solving power balance equations. Target set-up and beam pointing are facilitated by allowing users to specify positions and angular orientations using a variety of coordinates systems (e.g., that of any laser beam, target component, or diagnostic port). Analytic modeling for laser beam spatial profiles for OMEGA DPPs and NIF CPPs is used to compute laser intensity profiles throughout the grid of surface elements. VISRAD includes a variety of user-friendly graphics for setting up targets and displaying results, can readily display views from any point in space, and can be used to generate image sequences for animations. We will discuss recent improvements to conveniently assess beam capture on target and beam clearance of diagnostic components, as well as plans for future developments.

  15. 47 CFR 54.209 - Annual reporting requirements for designated eligible telecommunications carriers.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 3 2010-10-01 2010-10-01 false Annual reporting requirements for designated eligible telecommunications carriers. 54.209 Section 54.209 Telecommunication FEDERAL COMMUNICATIONS... Service Support § 54.209 Annual reporting requirements for designated eligible telecommunications carriers...

  16. National Ignition Facility sub-system design requirements integrated timing system SSDR 1.5.3

    International Nuclear Information System (INIS)

    Wiedwald, J.; Van Aersau, P.; Bliss, E.

    1996-01-01

    This System Design Requirement document establishes the performance, design, development, and test requirements for the Integrated Timing System, WBS 1.5.3 which is part of the NIF Integrated Computer Control System (ICCS). The Integrated Timing System provides all temporally-critical hardware triggers to components and equipment in other NIF systems

  17. 78 FR 32988 - Core Principles and Other Requirements for Designated Contract Markets; Correction

    Science.gov (United States)

    2013-06-03

    ... COMMODITY FUTURES TRADING COMMISSION 17 CFR Part 38 RIN 3038-AD09 Core Principles and Other... regarding Core Principles and Other Requirements for Designated Contract Markets by inserting a missing... regarding Core Principles and Other Requirements for Designated Contract Markets (77 FR 36612, June 19, 2012...

  18. Assistant in design of tissue targeting leads with radio-combinatorial screening vivo

    International Nuclear Information System (INIS)

    Liu Ciyi; Zeng Jun; Xie Wenhui; Hu Silong; Jin Muxiu

    2004-01-01

    The diagnostic and therapeutic efficiency of drug depends highly on the drug distribution in target tissues (tumor for example) both specifically and accumulatively. We report here a powerful approach in design of tissue targeting leads with the assistant of radio-combinatorial screening technique developed in our laboratory. Methods: The C-terminal amide tripeptide libraries were synthesized on Rink Amide-MBHA resin in the OXX aO1OXaO1O2O positional scanning format and iterative protoco. A technetium (V) oxo core[(TcO)3+] was bound to the N4-triligands of tripeptide libraries via four deprotonated anfide nitrogen atoms to form a structure of 99Tcm-tripeptoid libraries. The radio-combinatorial screening (RCS) in vivo was then carried out after SD rats and A549 tumor bearing mice received i.v. with 99Tcm-tripeptoid libraries. Results: Signals of tissue distribution and metabolism of libraries were recorded by g counting or imaging. From library of 8,000 99Tcm-tripeptoid members, the tissue targeting leads had been identified by RCS. Those included 99Tcm-DSG (RES), 99Tcm-VAA, and 99Tcm-VIG that had specific tissue targeting in kidney, stomach, and liver respectively. The percent injected dose per gram tissue (%ID/g) of 99Tcm labeled leads in their target tissues was highly structure-dependent The discovery of 99Tcm-VAA and 99Tcm-VIG indicates that side chain methyl at positionl and 2 are crucial for stomach and liver accumulating 99Tcm-tripeptoids. In the case of kidney targeting, Ser in the position 2 and 3 is crucial for 99Tcm-tripeptoids renal excretion and accumulation characteristics respectively. Conclusion: RCS in vivo is a powerful tool for design of tissue targeting leads. (authors)

  19. Design of a tensor polarized deuterium target polarized by spin-exchange with optically pumped NA

    International Nuclear Information System (INIS)

    Green, M.C.

    1984-01-01

    A proposed design for a tensor polarized deuterium target (approx. 10 15 atoms/cm 2 ) for nuclear physics studies in an electron storage ring accelerator is presented. The deuterium atoms undergo electron spin exchange with a highly polarized sodium vapor; this polarization is transferred to the deuterium nuclei via the hyperfine interaction. The deuterium nuclei obtain their tensor polarization through repeated electron spin exchange/hyperfine interactions. The sodium vapor polarization is maintained by standard optical pumping techniques. Model calculations are presented in detail leading to a discussion of the expected performance and the technical obstacles to be surmounted in the development of such a target

  20. Design of a tensor polarized deuterium target polarized by spin-exchange with optically pumped NA

    International Nuclear Information System (INIS)

    Green, M.C.

    1984-05-01

    A proposed design for a tensor polarized deuterium target (approx. 10 15 atoms/cm 2 ) for nuclear physics studies in an electron storage ring accelerator is presented. The deuterium atoms undergo electron spin exchange with a highly polarized sodium vapor; this polarization is transferred to the deuterium nuclei via the hyperfine interaction. The deuterium nuclei obtain their tensor polarization through repeated electron spin exchange/hyperfine interactions. The sodium vapor polarization is maintained by standard optical pumping techniques. Model calculations are presented in detail leading to a discussion of the expected performance and the technical obstacles to be surmounted in the development of such a target. 15 references, 10 figures

  1. Design requirements document for project W-520, immobilized low-activity waste disposal

    International Nuclear Information System (INIS)

    Ashworth, S.C.

    1998-01-01

    This design requirements document (DRD) identifies the functions that must be performed to accept, handle, and dispose of the immobilized low-activity waste (ILAW) produced by the Tank Waste Remediation System (TWRS) private treatment contractors and close the facility. It identifies the requirements that are associated with those functions and that must be met. The functional and performance requirements in this document provide the basis for the conceptual design of the Tank Waste Remediation System Immobilized Low-Activity Waste disposal facility project (W-520) and provides traceability from the program-level requirements to the project design activity

  2. National Ingition Facility subsystem design requirements optics subsystems SSDR 1.6

    International Nuclear Information System (INIS)

    English, R.E.

    1996-01-01

    This Subsystems Design Requirement (SSDR) document specifies the functions to be performed and the subsystems design requirements for the major optical components. These optical components comprise those custom designed and fabricated for amplification and transport of the full aperture NIF beam and does not include those off-the-shelf components that may be part of other optical sub-systems (i.e. alignment or diagnostic systems). This document also describes the optical component processing requirements and the QA/damage testing necessary to ensure that the optical components meet or exceed the requirements

  3. Development of requirements tracking and verification system for the software design of distributed control system

    Energy Technology Data Exchange (ETDEWEB)

    Jung, Chul Hwan; Kim, Jang Yeol; Kim, Jung Tack; Lee, Jang Soo; Ham, Chang Shik [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    1999-12-31

    In this paper a prototype of Requirement Tracking and Verification System(RTVS) for a Distributed Control System was implemented and tested. The RTVS is a software design and verification tool. The main functions required by the RTVS are managing, tracking and verification of the software requirements listed in the documentation of the DCS. The analysis of DCS software design procedures and interfaces with documents were performed to define the user of the RTVS, and the design requirements for RTVS were developed. 4 refs., 3 figs. (Author)

  4. Design requirements document for project W-520, immobilized low-activity waste disposal

    Energy Technology Data Exchange (ETDEWEB)

    Ashworth, S.C.

    1998-08-06

    This design requirements document (DRD) identifies the functions that must be performed to accept, handle, and dispose of the immobilized low-activity waste (ILAW) produced by the Tank Waste Remediation System (TWRS) private treatment contractors and close the facility. It identifies the requirements that are associated with those functions and that must be met. The functional and performance requirements in this document provide the basis for the conceptual design of the Tank Waste Remediation System Immobilized Low-Activity Waste disposal facility project (W-520) and provides traceability from the program-level requirements to the project design activity.

  5. Development of requirements tracking and verification system for the software design of distributed control system

    Energy Technology Data Exchange (ETDEWEB)

    Jung, Chul Hwan; Kim, Jang Yeol; Kim, Jung Tack; Lee, Jang Soo; Ham, Chang Shik [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    1998-12-31

    In this paper a prototype of Requirement Tracking and Verification System(RTVS) for a Distributed Control System was implemented and tested. The RTVS is a software design and verification tool. The main functions required by the RTVS are managing, tracking and verification of the software requirements listed in the documentation of the DCS. The analysis of DCS software design procedures and interfaces with documents were performed to define the user of the RTVS, and the design requirements for RTVS were developed. 4 refs., 3 figs. (Author)

  6. Planetary mission requirements, technology and design considerations for a solar electric propulsion stage

    Science.gov (United States)

    Cork, M. J.; Hastrup, R. C.; Menard, W. A.; Olson, R. N.

    1979-01-01

    High energy planetary missions such as comet rendezvous, Saturn orbiter and asteroid rendezvous require development of a Solar Electric Propulsion Stage (SEPS) for augmentation of the Shuttle-IUS. Performance and functional requirements placed on the SEPS are presented. These requirements will be used in evolution of the SEPS design, which must be highly interactive with both the spacecraft and the mission design. Previous design studies have identified critical SEPS technology areas and some specific design solutions which are also presented in the paper.

  7. Design requirements document for Project W-465, immobilized low-activity waste interim storage

    International Nuclear Information System (INIS)

    Burbank, D.A.

    1998-01-01

    The scope of this Design Requirements Document (DRD) is to identify the functions and associated requirements that must be performed to accept, transport, handle, and store immobilized low-activity waste (ILAW) produced by the privatized Tank Waste Remediation System (TWRS) treatment contractors. The functional and performance requirements in this document provide the basis for the conceptual design of the TWRS ILAW Interim Storage facility project and provides traceability from the program level requirements to the project design activity. Technical and programmatic risk associated with the TWRS planning basis are discussed in the Tank Waste Remediation System Decisions and Risk Assessment (Johnson 1994). The design requirements provided in this document will be augmented by additional detailed design data documented by the project

  8. The Evolution of Design Requirements in the Trajectory of Artificiality: A Research Agenda

    Science.gov (United States)

    Reymen, Isabelle; Romme, Georges

    Managing design requirements of complex socio-technical designs in heterogeneous and rapidly-changing environments demands new approaches. In this chapter we use the framework described by Krippendorff [1] to describe the evolution of requirements thinking and subsequently develop a research agenda. Krippendorff’s trajectory of artificiality shows an increasing dematerialization and human-centeredness of artifacts. He distinguishes six kinds of artifacts, namely material products; goods, services, and identities; interfaces; multi-user systems and networks; projects; and finally, discourses. Based on a review of the design literature, involving two major design journals, we find that the design of socio-technical systems currently tends to be situated on the level of multi-user systems and networks. Projects and discourses hardly get any attention in requirements thinking. We therefore develop an agenda for future research directed toward advancing requirements thinking at the level of projects and discourses as artifacts of design.

  9. Package design and nutritional profile of foods targeted at children in supermarkets in Montevideo, Uruguay.

    Science.gov (United States)

    Giménez, Ana; Saldamando, Luis de; Curutchet, María Rosa; Ares, Gastón

    2017-06-12

    Marketing of unhealthy products has been identified as one of the main characteristics of the food environment that negatively affects children's eating patterns. Restrictions on advertising of unhealthy foods to children have already been imposed in different countries. However, marketing strategies are not limited to broadcast and digital advertising, but also include package design. In this context, the current study aimed to describe the food products targeted at children and sold in supermarkets in Montevideo, Uruguay, in terms of package design and nutrient profile. Two supermarkets in Montevideo were selected for data collection. In each supermarket, all products targeted at children were identified. Products were analyzed in terms of package design and nutritional profile, considering the Pan American Health Organization Nutrient Profile Model. A total of 180 unique products were identified, which included a wide range of product categories. The great majority of the products corresponded to ultra-processed products with excessive amounts of sodium, free sugars, total fat, saturated fat, and/or trans fat, which are not recommended for frequent consumption. Several marketing strategies were identified in the design of packages to attract children's attention and drive their preferences. The most common strategies were the inclusion of cartoon characters, bright colors, childish lettering, and a wide range of claims related to health and nutrition, as well as the products' sensory and hedonic characteristics. The study's findings provide additional evidence on the need to regulate packaging of products targeted at children.

  10. Package design and nutritional profile of foods targeted at children in supermarkets in Montevideo, Uruguay

    Directory of Open Access Journals (Sweden)

    Ana Giménez

    Full Text Available Abstract: Marketing of unhealthy products has been identified as one of the main characteristics of the food environment that negatively affects children’s eating patterns. Restrictions on advertising of unhealthy foods to children have already been imposed in different countries. However, marketing strategies are not limited to broadcast and digital advertising, but also include package design. In this context, the current study aimed to describe the food products targeted at children and sold in supermarkets in Montevideo, Uruguay, in terms of package design and nutrient profile. Two supermarkets in Montevideo were selected for data collection. In each supermarket, all products targeted at children were identified. Products were analyzed in terms of package design and nutritional profile, considering the Pan American Health Organization Nutrient Profile Model. A total of 180 unique products were identified, which included a wide range of product categories. The great majority of the products corresponded to ultra-processed products with excessive amounts of sodium, free sugars, total fat, saturated fat, and/or trans fat, which are not recommended for frequent consumption. Several marketing strategies were identified in the design of packages to attract children’s attention and drive their preferences. The most common strategies were the inclusion of cartoon characters, bright colors, childish lettering, and a wide range of claims related to health and nutrition, as well as the products’ sensory and hedonic characteristics. The study’s findings provide additional evidence on the need to regulate packaging of products targeted at children.

  11. Magnetohydrodynamics (MHD) Engineering Test Facility (ETF) 200 MWe power plant. Design Requirements Document (DRD)

    Science.gov (United States)

    Rigo, H. S.; Bercaw, R. W.; Burkhart, J. A.; Mroz, T. S.; Bents, D. J.; Hatch, A. M.

    1981-01-01

    A description and the design requirements for the 200 MWe (nominal) net output MHD Engineering Test Facility (ETF) Conceptual Design, are presented. Performance requirements for the plant are identified and process conditions are indicated at interface stations between the major systems comprising the plant. Also included are the description, functions, interfaces and requirements for each of these major systems. The lastest information (1980-1981) from the MHD technology program are integrated with elements of a conventional steam electric power generating plant.

  12. National Ignition Facility subsystem design requirements transportation and handling, SSDR 1.1.1.3.2

    International Nuclear Information System (INIS)

    Yakuma, S.; McNairy, R.

    1996-01-01

    This Subsystem Design Requirement document is a development specification that establishes the performance, design, development, and test requirements for the Transportation ampersand Material Handling Systems (WBS 1.1.1.3.2) of the NIF Laser System (WBS 1.3 and 1.4). The NIF is a multi-pass, 192-beam, high-power, neodymium-glass laser that meets requirements set forth in the NIF SDR 002 (Laser System). 5 figs

  13. The Videographic Requirements Gathering Method for Adolescent-Focused Interaction Design

    Directory of Open Access Journals (Sweden)

    Tamara Peyton

    2014-08-01

    Full Text Available We present a novel method for conducting requirements gathering with adolescent populations. Called videographic requirements gathering, this technique makes use of mobile phone data capture and participant creation of media images. The videographic requirements gathering method can help researchers and designers gain intimate insight into adolescent lives while simultaneously reducing power imbalances. We provide rationale for this approach, pragmatics of using the method, and advice on overcoming common challenges facing researchers and designers relying on this technique.

  14. Environmental qualification design for NPP refurbishment to comply with revised licensing requirements

    International Nuclear Information System (INIS)

    MacBeth, M. J.; Hemmings, R. L.

    2002-01-01

    Recent Canadian Nuclear Regulatory decisions have imposed Environmental Qualification (EQ) requirements for twenty-four Reactor Building (RB) airlocks at the four-unit Pickering Nuclear Generating Station-B (PNGS-B) facility. This paper describes the EQ modification design work completed by CANATOM-NPM for the problematic aspects for such projects. The airlocks allow RB access while providing a containment boundary and are designed to prevent a potential breach of containment for all analysed station conditions. Each PNGS-B unit has three large equipment airlocks and three smaller personnel airlocks. The airlocks must function under postulated worst-case design basis accident(DBA) conditions for assigned mission durations. The design must ensure that accident conditions cannot spuriously initiate an un-requested door opening. CANATOM-NPM reviewed site data to specify the necessary EQ modifications required to satisfy licensing requirements while providing a correct and complete as-found record of the existing airlock installation. The design team assessed the installed airlocks configuration against environmental qualification requirements to finalize the list of necessary modifications. A comprehensive, cross-discipline review of proposed design changes was completed to identify any further changes required to satisfy the final EQ licensing goal. The design team also conducted a design review of the EQ modification installation strategy to integrate the design deliverables with the installation team requirements while attempting to minimize necessary outage time for EQ modification installations. This project was completed on schedule and within the cost limitations required by the client with comprehensive, high quality final design packages. Overall improvements were realized for OPG system drawings and the electronic documentation of design data. The EQ modifications designed by CANATOM-NPM will ensure the continued operation of the PNGS-B NPP past December 31

  15. Requirements for High Level Models Supporting Design Space Exploration in Model-based Systems Engineering

    OpenAIRE

    Haveman, Steven P.; Bonnema, G. Maarten

    2013-01-01

    Most formal models are used in detailed design and focus on a single domain. Few effective approaches exist that can effectively tie these lower level models to a high level system model during design space exploration. This complicates the validation of high level system requirements during detailed design. In this paper, we define requirements for a high level model that is firstly driven by key systems engineering challenges present in industry and secondly connects to several formal and d...

  16. 77 FR 16796 - Lead Requirements for Lead-Based Paint Activities in Target Housing and Child-Occupied Facilities...

    Science.gov (United States)

    2012-03-22

    ... document announces the receipt of Arkansas's rules established pursuant to its new 2011 statutory authority... program accreditation requirements, and work practice standards for lead-based paint activities in target...-based paint program and passed a new statute establishing a State lead-based paint program and changing...

  17. Spleen tyrosine kinase (Syk), a novel target of curcumin, is required for B lymphoma growth.

    Science.gov (United States)

    Gururajan, Murali; Dasu, Trivikram; Shahidain, Seif; Jennings, C Darrell; Robertson, Darrell A; Rangnekar, Vivek M; Bondada, Subbarao

    2007-01-01

    Curcumin (diferuloylmethane), a component of dietary spice turmeric (Curcuma longa), has been shown in recent studies to have therapeutic potential in the treatment of cancer, diabetes, arthritis, and osteoporosis. We investigated the ability of curcumin to modulate the growth of B lymphomas. Curcumin inhibited the growth of both murine and human B lymphoma in vitro and murine B lymphoma in vivo. We also demonstrate that curcumin-mediated growth inhibition of B lymphoma is through inhibition of the survival kinase Akt and its key target Bad. However, in vitro kinase assays show that Akt is not a direct target of curcumin. We identified a novel target for curcumin in B lymphoma viz spleen tyrosine kinase (Syk). Syk is constitutively activated in primary tumors and B lymphoma cell lines and curcumin down-modulates Syk activity accompanied by down-regulation of Akt activation. Moreover, we show that overexpression of Akt, a target of Syk, or Bcl-x(L), a target of Akt can overcome curcumin-induced apoptosis of B lymphoma cells. These observations suggest a novel growth promoting role for Syk in lymphoma cells.

  18. Implementing ergonomics in large-scale engineering design. Communicating and negotiating requirements in an organizational context

    Energy Technology Data Exchange (ETDEWEB)

    Wulff, Ingrid Anette

    1997-12-31

    This thesis investigates under what conditions ergonomic criteria are being adhered to in engineering design. Specifically, the thesis discusses (1) the ergonomic criteria implementation process, (2) designer recognition of ergonomic requirements and the organization of ergonomics, (3) issues important for the implementation of ergonomic requirements, (4) how different means for experience transfer in design and operation are evaluated by the designers, (5) how designers ensure usability of offshore work places, and (6) how project members experience and cope with the large amount of documentation in large-scale engineering. 84 refs., 11 figs., 18 tabs.

  19. Supplemental design requirements document enhanced radioactive and mixed waste storage Phase V Project W-112

    International Nuclear Information System (INIS)

    Ocampo, V.P.; Boothe, G.F.; Greager, T.M.; Johnson, K.D.; Kooiker, S.L.; Martin, J.D.

    1994-11-01

    This document provides additional and supplemental information to WHC-SD-W112-FDC-001, Project W-112 for radioactive and mixed waste storage. It provides additional requirements for the design and summarizes Westinghouse Hanford Company key design guidance and establishes the technical baseline agreements to be used for definitive design of the Project W-112 facilities

  20. Formal Functional Test Designs: Bridging the Gap Between Test Requirements and Test Specifications

    Science.gov (United States)

    Hops, Jonathan

    1993-01-01

    This presentation describes the testing life cycle, the purpose of the test design phase, and test design methods and gives an example application. Also included is a description of Test Representation Language (TRL), a summary of the language, and an example of an application of TRL. A sample test requirement and sample test design are included.

  1. Safeguards Guidance for Designers of Commercial Nuclear Facilities – International Safeguards Requirements for Uranium Enrichment Plants

    Energy Technology Data Exchange (ETDEWEB)

    Philip Casey Durst; Scott DeMuth; Brent McGinnis; Michael Whitaker; James Morgan

    2010-04-01

    For the past two years, the United States National Nuclear Security Administration, Office of International Regimes and Agreements (NA-243), has sponsored the Safeguards-by-Design Project, through which it is hoped new nuclear facilities will be designed and constructed worldwide more amenable to nuclear safeguards. In the course of this project it was recognized that commercial designer/builders of nuclear facilities are not always aware of, or understand, the relevant domestic and international safeguards requirements, especially the latter as implemented by the International Atomic Energy Agency (IAEA). To help commercial designer/builders better understand these requirements, a report was prepared by the Safeguards-by-Design Project Team that articulated and interpreted the international nuclear safeguards requirements for the initial case of uranium enrichment plants. The following paper summarizes the subject report, the specific requirements, where they originate, and the implications for design and construction. It also briefly summarizes the established best design and operating practices that designer/builder/operators have implemented for currently meeting these requirements. In preparing the subject report, it is recognized that the best practices are continually evolving as the designer/builder/operators and IAEA consider even more effective and efficient means for meeting the safeguards requirements and objectives.

  2. A Study on Control System Design Based on ARM Sea Target Search System

    Directory of Open Access Journals (Sweden)

    Lin Xinwei

    2015-01-01

    Full Text Available The infrared detector is used for sea target search, which can assist humans in searching suspicious objects at night and under poor visibility conditions, and improving search efficiency. This paper applies for interrupt and stack technology to solve problems of data losses that may be caused by one-to-many multi-byte protocol communication. Meanwhile, this paper implements hardware and software design of the system based on industrial-grade ARM control chip and uC / OS-II embedded operating system. The control system in the sea target search system is an information exchange and control center of the whole system, which solves the problem of controlling over the shooting angle of the infrared detector in the process of target search. After testing, the control system operates stably and reliably, and realizes rotation and control functions of the pan/tilt platform during automatic search, manual search and track.

  3. Thermal-hydraulic design concept of the solid-target system of spallation neutron source

    International Nuclear Information System (INIS)

    Tanaka, F.; Hibiki, T.; Saito, Y.; Takeda, T.; Mishima, K.

    2001-01-01

    In relation to thermal-hydraulic design of the N-Arena solid-target system of the JHF project, heat transfer experiments were performed to obtain experimental data systematically on heat transfer coefficient and CHF for vertical upward and horizontal flows in a thin rectangular channel simulating a coolant channel of the proposed spallation neutron source. Thermal-hydraulic correlations which can be used for design calculations were proposed based on the obtained data. Finally tentative results of feasibility study on maximum beam power which could be attained with a solid target were presented. The result indicated that the condition for the onset of nucleate boiling is the most significant limiting factor to the maximum beam power. (author)

  4. Conceptual design of low activation target chamber and components for the National Ignition Facility

    International Nuclear Information System (INIS)

    Streckert, H.H.; Schultz, K.R.; Sager, G.T.; Kantner, R.D.

    1996-01-01

    The baseline design for the target chamber and chamber components for the National Ignition Facility (NIF) consists of aluminum alloy structural material. Low activation composite chamber and components have important advantages including enhanced environmental and safety characteristics and improved accessibility due to reduced neutron-induced radioactivity. A low activation chamber can be fabricated from carbon fiber reinforced epoxy using thick wall laminate technology similar to submarine bow dome fabrication for the U.S. Navy. A risk assessment analysis indicates that a composite chamber has a reasonably high probability of success, but that an aluminum alloy chamber represents a lower risk. Use of low activation composite materials for several chamber components such as the final optics assemblies, the target positioner and inserter, the diagnostics manipulator tubes, and the optics beam tubes would offer an opportunity to make significant reductions in post-shot radiation dose rate with smaller, less immediate impact on the NIF design. 7 refs., 3 figs

  5. LH2 Target Design & Position Survey Techniques for the MUSE experiment for Precise Proton Radius Measurement

    Science.gov (United States)

    Le Pottier, Luc; Roy, Pryiashee; Lorenzon, Wolfgang; Raymond, Richard; Steinberg, Noah; Rossi de La Fuente, Erick; MUSE (MUon proton Scattering Experiment) Collaboration

    2017-09-01

    The proton radius puzzle is a currently unresolved problem which has intrigued the scientific community, dealing with a 7 σ discrepancy between the proton radii determined from muonic hydrogen spectroscopy and electron scattering measurements. The MUon Scattering Experiment (MUSE) aims to resolve this puzzle by performing the first simultaneous elastic scattering measurements of both electrons and muons on the proton, which will allow the comparison of the radii from the two interactions with reduced systematic uncertainties. The data from this experiment is expected to provide the best test of lepton universality to date. The experiment will take place at the Paul Scherrer Institute in Switzerland in 2018. An essential component of the experiment is a liquid hydrogen (LH2) cryotarget system. Our group at the University of Michigan is responsible for the design, fabrication and installation of this system. Here we present our LH2 target cell design and fabrication techniques for successful operation at 20 K and 1 atm, and our computer vision-based target position survey system which will determine the position of the target, installed inside a vacuum chamber, with 0.01 mm or better precision at the height of the liquid hydrogen target and along the beam direction during the experiment.

  6. The Design of New HIV-IN Tethered Bifunctional Inhibitors using Multiple Microdomain Targeted Docking.

    Science.gov (United States)

    Ciubotaru, Mihai; Musat, Mihaela Georgiana; Surleac, Marius; Ionita, Elena; Petrescu, Andrei Jose; Abele, Edgars; Abele, Ramona

    2018-04-05

    Currently used antiretroviral HIV therapy drugs exclusively target critical groups in the enzymes essential for the viral life cycle. Increased mutagenesis of their genes, changes these viral enzymes which once mutated can evade therapeutic targeting, effects which confer drug resistance. To circumvent this, our review addresses a strategy to design and derive HIV-Integrase (HIV-IN) inhibitors which simultaneously target two IN functional domains, rendering it inactive even if the enzyme accumulates many mutations. First we review the enzymatic role of IN to insert the copied viral DNA into a chromosome of the host T lymphocyte, highlighting its main functional and structural features to be subjected to inhibitory action. From a functional and structural perspective we present all classes of HIV-IN inhibitors with their most representative candidates. For each chosen compound we also explain its mechanism of IN inhibition. We use the recently resolved cryo EM IN tetramer intasome DNA complex [1] onto which we dock various reference IN inhibitory chemical scaffolds such as to target adjacent functional IN domains. Pairing compounds with complementary activity, which dock in the vicinity of a IN structural microdomain, we design bifunctional new drugs which may not only be more resilient to IN mutations but also may be more potent inhibitors than their original counterparts. In the end of our review we propose synthesis pathways to link such paired compounds with enhanced synergistic IN inhibitory effects. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  7. Design and construction of a time-of-flight wall detector at External Target Facility of HIRFL-CSR

    Science.gov (United States)

    Sun, Y.; Sun, Z. Y.; Yu, Y. H.; Yan, D.; Tang, S. W.; Sun, Y. Z.; Wang, S. T.; Zhang, X. H.; Yue, K.; Fang, F.; Chen, J. L.; Zhang, Y. J.; Hu, B. T.

    2018-06-01

    A Time-Of-Flight Wall (TOFW) detector has been designed and constructed at the External Target Facility (ETF) of HIRFL-CSR. The detector covers a sensitive area of 1.2 × 1.2 m2 and consists of 30 modules. Each module is composed of a long plastic scintillator bar with two photo-multiplier tubes coupled at both ends for readout. The design and manufacture details are described and the test results are reported. The performance of the TOFW detector has been tested and measured with cosmic rays and a 310 MeV/u 40Ar beam. The results show that the time resolutions of all the TOFW modules are better than 128 ps, satisfying the requirements of the experiments which will be carried out at the ETF.

  8. Computer-aided design of control systems to meet many requirements

    Science.gov (United States)

    Schy, A. A.; Adams, W. M., Jr.; Johnson, K. G.

    1974-01-01

    A method is described for using nonlinear programing in the computer-aided design of airplane control systems. It is assumed that the quality of such systems depends on many criteria. These criteria are included in the constraints vector (instead of attempting to combine them into a single scalar criterion, as is usually done), and the design proceeds through a sequence of nonlinear programing solutions in which the designer varies the specification of sets of requirements levels. The method is applied to design of a lateral stability augmentation system (SAS) for a fighter airplane, in which the requirements vector is chosen from the official handling qualities specifications. Results are shown for several simple SAS configurations designed to obtain desirable handling qualities over all design flight conditions with minimum feedback gains. The choice of the final design for each case is not unique but depends on the designer's decision as to which achievable set of requirements levels represents the best for that system. Results indicate that it may be possible to design constant parameter SAS which can satisfy the most stringent handling qualities requirements for fighter airplanes in all flight conditions. The role of the designer as a decision maker, interacting with the computer program, is discussed. Advantages of this type of designer-computer interaction are emphasized. Desirable extensions of the method are indicated.

  9. Design challenges in nanoparticle-based platforms: Implications for targeted drug delivery systems

    Science.gov (United States)

    Mullen, Douglas Gurnett

    Characterization and control of heterogeneous distributions of nanoparticle-ligand components are major design challenges for nanoparticle-based platforms. This dissertation begins with an examination of poly(amidoamine) (PAMAM) dendrimer-based targeted delivery platform. A folic acid targeted modular platform was developed to target human epithelial cancer cells. Although active targeting was observed in vitro, active targeting was not found in vivo using a mouse tumor model. A major flaw of this platform design was that it did not provide for characterization or control of the component distribution. Motivated by the problems experienced with the modular design, the actual composition of nanoparticle-ligand distributions were examined using a model dendrimer-ligand system. High Pressure Liquid Chromatography (HPLC) resolved the distribution of components in samples with mean ligand/dendrimer ratios ranging from 0.4 to 13. A peak fitting analysis enabled the quantification of the component distribution. Quantified distributions were found to be significantly more heterogeneous than commonly expected and standard analytical parameters, namely the mean ligand/nanoparticle ratio, failed to adequately represent the component heterogeneity. The distribution of components was also found to be sensitive to particle modifications that preceded the ligand conjugation. With the knowledge gained from this detailed distribution analysis, a new platform design was developed to provide a system with dramatically improved control over the number of components and with improved batch reproducibility. Using semi-preparative HPLC, individual dendrimer-ligand components were isolated. The isolated dendrimer with precise numbers of ligands were characterized by NMR and analytical HPLC. In total, nine different dendrimer-ligand components were obtained with degrees of purity ≥80%. This system has the potential to serve as a platform to which a precise number of functional molecules

  10. Design and implement of infrared small target real-time detection system based on pipeline technology

    Science.gov (United States)

    Sun, Lihui; Wang, Yongzhong; He, Yongqiang

    2007-01-01

    The detection for motive small target in infrared image sequence has become a hot topic nowadays. Background suppress algorithm based on minim gradient median filter and temporal recursion target detection algorithm are introduced. On the basis of contents previously mentioned, a four stages pipeline structure infrared small target detection process system, which aims at characters of algorithm complexity, large amounts of data to process, high frame frequency and exigent real-time character in this kind of application, is designed and implemented. The logical structure of the system was introduced and the function and signals flows are programmed. The system is composed of two FPGA chips and two DSP chips of TI. According to the function of each part, the system is divided into image preprocess stage, target detection stage, track relation stage and image output stage. The experiment of running algorithms on the system presented in this paper proved that the system could meet acquisition and process of 50Hz 240x320 digital image and the system could real time detect small target with a signal-noise ratio more than 3 reliably. The system achieves the characters of large amount of memory, high real-time processing, excellent extension and favorable interactive interface.

  11. Optimized beryllium target design for indirectly driven inertial confinement fusion experiments on the National Ignition Facility

    Energy Technology Data Exchange (ETDEWEB)

    Simakov, Andrei N., E-mail: simakov@lanl.gov; Wilson, Douglas C.; Yi, Sunghwan A.; Kline, John L.; Batha, Steven H. [Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, New Mexico 87545 (United States); Clark, Daniel S.; Milovich, Jose L.; Salmonson, Jay D. [Lawrence Livermore National Laboratory, P.O. Box 808, Livermore, California 94551 (United States)

    2014-02-15

    For indirect drive inertial confinement fusion, Beryllium (Be) ablators offer a number of important advantages as compared with other ablator materials, e.g., plastic and high density carbon. In particular, the low opacity and relatively high density of Be lead to higher rocket efficiencies giving a higher fuel implosion velocity for a given X-ray drive; and to higher ablation velocities providing more ablative stabilization and reducing the effect of hydrodynamic instabilities on the implosion performance. Be ablator advantages provide a larger target design optimization space and can significantly improve the National Ignition Facility (NIF) [J. D. Lindl et al., Phys. Plasmas 11, 339 (2004)] ignition margin. Herein, we summarize the Be advantages, briefly review NIF Be target history, and present a modern, optimized, low adiabat, Revision 6 NIF Be target design. This design takes advantage of knowledge gained from recent NIF experiments, including more realistic levels of laser-plasma energy backscatter, degraded hohlraum-capsule coupling, and the presence of cross-beam energy transfer.

  12. Rational Design of Cancer-Targeted Benzoselenadiazole by RGD Peptide Functionalization for Cancer Theranostics.

    Science.gov (United States)

    Yang, Liye; Li, Wenying; Huang, Yanyu; Zhou, Yangliang; Chen, Tianfeng

    2015-09-01

    A cancer-targeted conjugate of the selenadiazole derivative BSeC (benzo[1,2,5] selenadiazole-5-carboxylic acid) with RGD peptide as targeting molecule and PEI (polyethylenimine) as a linker is rationally designed and synthesized in the present study. The results show that RGD-PEI-BSeC forms nanoparticles in aqueous solution with a core-shell nanostructure and high stability under physiological conditions. This rational design effectively enhances the selective cellular uptake and cellular retention of BSeC in human glioma cells, and increases its selectivity between cancer and normal cells. The nanoparticles enter the cells through receptor-mediated endocytosis via clathrin-mediated and nystatin-dependent lipid raft-mediated pathways. Internalized nanoparticles trigger glioma cell apoptosis by activation of ROS-mediated p53 phosphorylation. Therefore, this study provides a strategy for the rational design of selenium-containing cancer-targeted theranostics. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  13. Inflation Targeting and Quantitative Tightening: Effects of Reserve Requirements in Peru

    OpenAIRE

    Adrián Armas; Paul Castillo; Marco Vega

    2014-01-01

    This paper provides an overview of the reserve requirement measures undertaken by the Central Bank of Peru. It provides a rationale for the use of these instruments as well as empirical evidence of their effectiveness. In general, the results show that tightening reserve requirements has the desired effects on interest rates and credit levels at both banks and smaller financial institutions (cajas municipales).

  14. Project W-236A, work plan for preparation of a design requirements document

    International Nuclear Information System (INIS)

    Groth, B.D.

    1995-01-01

    This work plan outlines the tasks necessary, and defines the organizational responsibilities for preparing a Design Requirements Document (DRD) for project W-236A, Multi-Function Waste Tank Facility (MWTF). A DRD is a Systems Engineering document which bounds, at a high level, the requirements of a discrete system element of the Tank Waste Remediation System (TWRS) Program. This system element is usually assigned to a specific project, in this case the MWTF. The DRD is the document that connects the TWRS program requirements with the highest level projects requirements and provides the project's link to the overall TWRS mission. The MWTF DRD effort is somewhat unique in that the project is already in detailed design, whereas a DRO is normally prepared prior to preliminary design. The MWTF design effort was initiated with a Functional Design Criteria (FDC) and a Supplemental Design Requirements Document (SDRD) bounding the high level requirements. Another unique aspect of this effort is that some of the TWRS program requirements are still in development. Because of these unique aspects of the MWTF DRD development, the MWTF will be developed from existing TWRS Program requirements and project specific requirements contained in the FDC and SDRD. The following list describes the objectives of the MWTF DRD: determine the primary functions of the tanks through a functional decomposition of the TWRS Program high level functions; allocate the primary functions to a sub-system architecture for the tanks; define the fundamental design features in terms of performance requirements for the system and subsystems; identify system interfaces and design constraints; and document the results in a DRD

  15. Design requirements of instrumentation and control systems for next generation reactor

    International Nuclear Information System (INIS)

    Koo, In Soo; Lee, Byung Sun; Park, Kwang Hyun; Park, Heu Yoon; Lee, Dong Young; Kim, Jung Taek; Hwang, In Koo; Chung, Chul Hwan; Hur, Seop; Kim, Chang Hoi; Na, Nan Ju

    1994-03-01

    In this report, the basic design requirements of Instrumentation and Control systems for next generation reactor are described, which are top-tier level, to support the advanced I and C systems. It contains the requirements in accordance with the plant reliability, the plant performance, the operator's aid functions, the features for maintenance and testing, licensing issues for I and C systems. Advanced I and C systems are characterized such as the application of the digital and the human engineering technologies. To development of this requirements, the I and C systems for the foreign passive and the evolutionary types of reactor and the domestic conventional reators were reviewed and anlysed. At the detail design stage, these requirements will be used for top-tier requirements. To develop the detail design requirements in the future, more quantitive and qualitive analyses are need to be added. (Author) 44 refs

  16. Preliminary design requirements document (DRD) for Project W-236B, ''Initial Pretreatment Module''

    International Nuclear Information System (INIS)

    Swanson, L.M.

    1995-01-01

    The scope of this Design Requirements Document (DRD) is to identify and define the functions, with associated requirements, which must be performed to separate Hanford Site tank waste supernatants into low-level and high-level fractions. This documents sets forth function requirements, performance requirements, and design constraints necessary to begin conceptual design for the Initial Pretreatment Module (IPM). System and physical interfaces between the IPM project and the Tank Waste Remediation System (TWRS) are identified. The constraints, performance requirements, and transfer of information and data across a technical interface will be documented in an Interface Control Document. Supplemental DRDs will be prepared to provide more detailed requirements specific to systems described in the DRD

  17. USER REQUIREMENTS CUSTOMIZATION AND ATTRACTIVE QUALITY CREATION FOR DESIGN IMPROVEMENT ATTRIBUTES

    Directory of Open Access Journals (Sweden)

    Ismail Wilson Taifa

    2017-03-01

    Full Text Available The aim of this paper was to customize user requirements and quality creation for design improvement of furniture. The major purpose has been achieved with the use of Quality Function Deployment technique and Kano Model. The study involved 564 students from 3 engineering colleges. Extensive user requirements were identified with the help of Questionnaires. The use of House of Quality, Kano Model and Pareto Diagram helped in prioritizing all important features which are needed in customizing user requirements. The prioritized requirements include ergonomic design, desk adjustability, comfortability, product corners (sharp corners and latest material. All these factors both got high relative and absolute weight. Therefore, more engineering efforts need to be directed towards these requirements for achieving user customization for design improvement. The developed House of Quality with the help of Kano Model results has proved to be a good tool in customizing user requirements.

  18. Design requirements of instrumentation and control systems for next generation reactor

    Energy Technology Data Exchange (ETDEWEB)

    Koo, In Soo; Lee, Byung Sun; Park, Kwang Hyun; Park, Heu Yoon; Lee, Dong Young; Kim, Jung Taek; Hwang, In Koo; Chung, Chul Hwan; Hur, Seop; Kim, Chang Hoi; Na, Nan Ju [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    1994-03-01

    In this report, the basic design requirements of Instrumentation and Control systems for next generation reactor are described, which are top-tier level, to support the advanced I and C systems. It contains the requirements in accordance with the plant reliability, the plant performance, the operator`s aid functions, the features for maintenance and testing, licensing issues for I and C systems. Advanced I and C systems are characterized such as the application of the digital and the human engineering technologies. To development of this requirements, the I and C systems for the foreign passive and the evolutionary types of reactor and the domestic conventional reators were reviewed and anlysed. At the detail design stage, these requirements will be used for top-tier requirements. To develop the detail design requirements in the future, more quantitive and qualitive analyses are need to be added. (Author) 44 refs.

  19. Constraints on LISA Pathfinder's Self-Gravity: Design Requirements, Estimates and Testing Procedures

    Science.gov (United States)

    Armano, M.; Audley, H.; Auger, G.; Baird, J.; Binetruy, P.; Born, M.; Bortoluzzi, M.; Brandt, Nico; Bursi, Alessandro; Slutsky. J.; hide

    2016-01-01

    LISA Pathfinder satellite was launched on 3 December 2015 toward the Sun Earth first Lagrangian point (L1) where the LISA Technology Package (LTP), which is the main science payload, will be tested. LTP achieves measurements of differential acceleration of free-falling test masses (TMs) with sensitivity below 3 x 10(exp -14) m s(exp -2) Hz(exp - 1/2) within the 130 mHz frequency band in one dimension. The spacecraft itself is responsible for the dominant differential gravitational field acting on the two TMs. Such a force interaction could contribute a significant amount of noise and thus threaten the achievement of the targeted free-fall level. We prevented this by balancing the gravitational forces to the sub nm s(exp -2) level, guided by a protocol based on measurements of the position and the mass of all parts that constitute the satellite, via finite element calculation tool estimates. In this paper, we will introduce the gravitational balance requirements and design, and then discuss our predictions for the balance that will be achieved in flight.

  20. The Translation between Functional Requirements and Design Parameters for Robust Design

    DEFF Research Database (Denmark)

    Göhler, Simon Moritz; Husung, Stephan; Howard, Thomas J.

    2016-01-01

    The specification of and justification for design parameter (DP) tolerances are primarily based on the acceptable variation of the functions’ performance and the functions’ sensitivity to the design parameters. However, why certain tolerances are needed is often not transparent, especially...... computer aided functional tolerancing. Non-optimal tolerances yield potentials for cost improvements in manufacturing and more consistency of the functional performance of the product. In this contribution a framework is proposed to overcome the observed problems and increase the clarity, transparency...... and traceability of tolerances by analyzing the translation between the DPs and their influence on the final function....

  1. Design requirements and development of an airborne descent path definition algorithm for time navigation

    Science.gov (United States)

    Izumi, K. H.; Thompson, J. L.; Groce, J. L.; Schwab, R. W.

    1986-01-01

    The design requirements for a 4D path definition algorithm are described. These requirements were developed for the NASA ATOPS as an extension of the Local Flow Management/Profile Descent algorithm. They specify the processing flow, functional and data architectures, and system input requirements, and recommended the addition of a broad path revision (reinitialization) function capability. The document also summarizes algorithm design enhancements and the implementation status of the algorithm on an in-house PDP-11/70 computer. Finally, the requirements for the pilot-computer interfaces, the lateral path processor, and guidance and steering function are described.

  2. Mechanical activation of mammalian target of rapamycin pathway is required for cartilage development

    OpenAIRE

    Guan, Yingjie; Yang, Xu; Yang, Wentian; Charbonneau, Cherie; Chen, Qian

    2014-01-01

    Mechanical stress regulates development by modulating cell signaling and gene expression. However, the cytoplasmic components mediating mechanotransduction remain unclear. In this study, elimination of muscle contraction during chicken embryonic development resulted in a reduction in the activity of mammalian target of rapamycin (mTOR) in the cartilaginous growth plate. Inhibition of mTOR activity led to significant inhibition of chondrocyte proliferation, cartilage tissue growth, and express...

  3. Generalized requirements and decompositions for the design of test parts for micro additive manufacturing research

    DEFF Research Database (Denmark)

    Thompson, Mary Kathryn; Clemmensen, Line Katrine Harder

    2015-01-01

    The design of experimental test parts to characterize micro additive manufacturing (AM) processes is challenging due to the influence of the manufacturing and metrology processes. This work builds on the lessons learned from a case study in the literature to derive generalized requirements and high...... level decompositions for the design of test parts and the design of experiments to characterize micro additive manufacturing processes. While the test parts and the experiments described are still work in progress, the generic requirements derived from them can serve as a starting point for the design...... of other micro additive manufacturing related studies and their decompositions can help structure future work....

  4. Nuclear data requirements for the ADS conceptual design EFIT: Uncertainty and sensitivity study

    Energy Technology Data Exchange (ETDEWEB)

    Garcia-Herranz, N., E-mail: nuria@din.upm.e [Departamento de Ingenieria Nuclear, Universidad Politecnica de Madrid (Spain); Instituto de Fusion Nuclear, Universidad Politecnica de Madrid (Spain); Cabellos, O. [Departamento de Ingenieria Nuclear, Universidad Politecnica de Madrid (Spain); Instituto de Fusion Nuclear, Universidad Politecnica de Madrid (Spain); Alvarez-Velarde, F. [CIEMAT (Spain); Sanz, J. [Instituto de Fusion Nuclear, Universidad Politecnica de Madrid (Spain); Departamento de Ingenieria Energetica, UNED (Spain); Gonzalez-Romero, E.M. [CIEMAT (Spain); Juan, J. [Laboratorio de Estadistica, Universidad Politecnica de Madrid (Spain)

    2010-11-15

    In this paper, we assess the impact of activation cross-section uncertainties on relevant fuel cycle parameters for a conceptual design of a modular European Facility for Industrial Transmutation (EFIT) with a 'double strata' fuel cycle. Next, the nuclear data requirements are evaluated so that the parameters can meet the assigned design target accuracies. Different discharge burn-up levels are considered: a low burn-up, corresponding to the equilibrium cycle, and a high burn-up level, simulating the effects on the fuel of the multi-recycling scenario. In order to perform this study, we propose a methodology in two steps. Firstly, we compute the uncertainties on the system parameters by using a Monte Carlo simulation, as it is considered the most reliable approach to address this problem. Secondly, the analysis of the results is performed by a sensitivity technique, in order to identify the relevant reaction channels and prioritize the data improvement needs. Cross-section uncertainties are taken from the EAF-2007/UN library since it includes data for all the actinides potentially present in the irradiated fuel. Relevant uncertainties in some of the fuel cycle parameters have been obtained, and we conclude with recommendations for future nuclear data measurement programs, beyond the specific results obtained with the present nuclear data files and the limited available covariance information. A comparison with the uncertainty and accuracy analysis recently published by the WPEC-Subgroup26 of the OECD using BOLNA covariance matrices is performed. Despite the differences in the transmuter reactor used for the analysis, some conclusions obtained by Subgroup26 are qualitatively corroborated, and improvements for additional cross sections are suggested.

  5. Design, construction, and characterization of high-performance membrane fusion devices with target-selectivity.

    Science.gov (United States)

    Kashiwada, Ayumi; Yamane, Iori; Tsuboi, Mana; Ando, Shun; Matsuda, Kiyomi

    2012-01-31

    Membrane fusion proteins such as the hemagglutinin glycoprotein have target recognition and fusion accelerative domains, where some synergistically working elements are essential for target-selective and highly effective native membrane fusion systems. In this work, novel membrane fusion devices bearing such domains were designed and constructed. We selected a phenylboronic acid derivative as a recognition domain for a sugar-like target and a transmembrane-peptide (Leu-Ala sequence) domain interacting with the target membrane, forming a stable hydrophobic α-helix and accelerating the fusion process. Artificial membrane fusion behavior between the synthetic devices in which pilot and target liposomes were incorporated was characterized by lipid-mixing and inner-leaflet lipid-mixing assays. Consequently, the devices bearing both the recognition and transmembrane domains brought about a remarkable increase in the initial rate for the membrane fusion compared with the devices containing the recognition domain alone. In addition, a weakly acidic pH-responsive device was also constructed by replacing three Leu residues in the transmembrane-peptide domain by Glu residues. The presence of Glu residues made the acidic pH-dependent hydrophobic α-helix formation possible as expected. The target-selective liposome-liposome fusion was accelerated in a weakly acidic pH range when the Glu-substituted device was incorporated in pilot liposomes. The use of this pH-responsive device seems to be a potential strategy for novel applications in a liposome-based delivery system. © 2011 American Chemical Society

  6. Design basis and requirements for 241-SY Modular Exhauster concrete pad and retaining wall

    International Nuclear Information System (INIS)

    Kriskovich, J.R.

    1994-01-01

    The purpose of this document is to serve as the design and functional requirements for a concrete pad for the new 241-SY Modular Exhauster and for a retaining wall to be built near the new ventilation systems

  7. Acoustic design of open-plan offices and comparison of requirements in the Nordic countries

    DEFF Research Database (Denmark)

    Petersen, Claus Møller; Rasmussen, Birgit

    2018-01-01

    In the Nordic countries, most office buildings include open-plan offices. However, to optimize working conditions, such spaces require special acoustic design to obtain reasonable sound attenuation between groups and satisfactory speech intelligibility internally in groups, although optimal worki...

  8. National Ingition Facility subsystem design requirements optical mounts SSDR 1.4.4

    International Nuclear Information System (INIS)

    Richardson, M.

    1996-01-01

    This SSDR establishes the performance, design, development and test requirements for NIF Beam Transport Optomechanical Subsystems. optomechanical Subsystems includes the mounts for the beam transport mirrors, LMl - LM8, the polarizer mount, and the spatial filter lens mounts

  9. Public transport service design requirements for the changing face of the South African customer

    CSIR Research Space (South Africa)

    Mokonyama, Mathetha T

    2008-04-01

    Full Text Available Based on the life cycle dynamics of the South African population, the paper investigates the implications of such dynamics on the design requirements of public transport services. The life cycle dynamics considered in this paper refer specifically...

  10. Specification of Behavioural Requirements within Compositional Multi-Agent System Design

    OpenAIRE

    Herlea, D.E.; Jonker, C.M.; Treur, J.; Wijngaards, N.J.E.

    1999-01-01

    In this paper it is shown how informal and formal specification of behavioural requirements and scenarios for agents and multi-agent systems can be integrated within multi-agent system design. In particular, it is addressed how a compositional

  11. Preconceptual engineering design for the APT 3He Target/Blanket concept

    International Nuclear Information System (INIS)

    Mensink, D.L.

    1994-01-01

    A preconceptual engineering design has been developed for the 3 He Target/Blanket (T/B) System for the Accelerator Production of Tritium Project. This concept uses an array of pressure tubes containing tungsten rods for the neutron spallation source and 3 He gas contained in a metal tank and blanket tubes as the tritium production material. The engineering design is based on a physics model optimized for efficient tritium production. Principle engineering consideration were: provisions for cooling all materials including the 3 He gas; containment of the gas and radionuclides; remote handling; material compatibility; minimization of 3 He, D 2 O, and activated waste; modularity; and manufacturability. The design provides a basis for estimating the cost to implement the system

  12. Design requirements for SRB production control system. Volume 3: Package evaluation, modification and hardware

    Science.gov (United States)

    1981-01-01

    The software package evaluation was designed to analyze commercially available, field-proven, production control or manufacturing resource planning management technology and software package. The analysis was conducted by comparing SRB production control software requirements and conceptual system design to software package capabilities. The methodology of evaluation and the findings at each stage of evaluation are described. Topics covered include: vendor listing; request for information (RFI) document; RFI response rate and quality; RFI evaluation process; and capabilities versus requirements.

  13. Hohlraum Target Alignment from X-ray Detector Images using Starburst Design Patterns

    International Nuclear Information System (INIS)

    Leach, R.R.; Conder, A.; Edwards, O.; Kroll, J.; Kozioziemski, B.; Mapoles, E.; McGuigan, D.; Wilhelmsen, K.

    2010-01-01

    National Ignition Facility (NIF) is a high-energy laser facility comprised of 192 laser beams focused with enough power and precision on a hydrogen-filled spherical, cryogenic target to initiate a fusion reaction. The target container, or hohlraum, must be accurately aligned to an x-ray imaging system to allow careful monitoring of the frozen fuel layer in the target. To achieve alignment, x-ray images are acquired through starburst-shaped windows cut into opposite sides of the hohlraum. When the hohlraum is in alignment, the starburst pattern pairs match nearly exactly and allow a clear view of the ice layer formation on the edge of the target capsule. During the alignment process, x-ray image analysis is applied to determine the direction and magnitude of adjustment required. X-ray detector and source are moved in concert during the alignment process. The automated pointing alignment system described here is both accurate and efficient. In this paper, we describe the control and associated image processing that enables automation of the starburst pointing alignment.

  14. Customizable de novo design strategies for DOCK: Application to HIVgp41 and other therapeutic targets.

    Science.gov (United States)

    Allen, William J; Fochtman, Brian C; Balius, Trent E; Rizzo, Robert C

    2017-11-15

    De novo design can be used to explore vast areas of chemical space in computational lead discovery. As a complement to virtual screening, from-scratch construction of molecules is not limited to compounds in pre-existing vendor catalogs. Here, we present an iterative fragment growth method, integrated into the program DOCK, in which new molecules are built using rules for allowable connections based on known molecules. The method leverages DOCK's advanced scoring and pruning approaches and users can define very specific criteria in terms of properties or features to customize growth toward a particular region of chemical space. The code was validated using three increasingly difficult classes of calculations: (1) Rebuilding known X-ray ligands taken from 663 complexes using only their component parts (focused libraries), (2) construction of new ligands in 57 drug target sites using a library derived from ∼13M drug-like compounds (generic libraries), and (3) application to a challenging protein-protein interface on the viral drug target HIVgp41. The computational testing confirms that the de novo DOCK routines are robust and working as envisioned, and the compelling results highlight the potential utility for designing new molecules against a wide variety of important protein targets. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

  15. Design Optimisation of a High Intensity Beam Facility and Feasibility Experiment of a Solid Fragmented Target

    CERN Document Server

    Charitonidis, Nikolaos; Rivkin, Leonid

    2014-06-13

    The present PhD thesis describes the design, execution and results of the HRMT-10 experiment performed at the HiRadMat facility of the CERN/SPS complex. The first part of the thesis covers the design optimization studies of the HiRadMat facility, focusing in particular on the radiation protection issues. A detailed Monte-Carlo model of the facility has been developed and validated through comparison with measurements. A very satisfactory agreement between the simulation and the experimental data is observed. In the second part of this thesis, a novel feasibility experiment of a fragmented solid target for a future Neutrino Factory or a Super Beam facility, able to support high beam powers ( 1 MW) is presented in detail. A solid granular target has been proposed as an interesting alternative to an open Hg jet target, presently considered as the baseline for such facilities, but posing considerable technical challenges. The HRMT-10 experiment seeks to address the lack of experimental data of the feasibility of...

  16. Design specification for the European Spallation Source neutron generating target element

    International Nuclear Information System (INIS)

    Aguilar, A.; Sordo, F.; Mora, T.; Mena, L.; Mancisidor, M.; Aguilar, J.; Bakedano, G.; Herranz, I.; Luna, P.; Magan, M.; Vivanco, R.; Jimenez-Villacorta, F.; Sjogreen, K.; Oden, U.; Perlado, J.M.

    2017-01-01

    The paper addresses some of the most relevant issues concerning the thermal hydraulics and radiation damage of the neutron generation target to be built at the European Spallation Source as recently approved after a critical design review. The target unit consists of a set of Tungsten blocks placed inside a wheel of 2.5 m diameter which rotates at some 0.5 Hz in order to distribute the heat generated from incoming protons which reach the target in the radial direction. The spallation material elements are composed of an array of Tungsten pieces which rest on a rotating steel support (the cassette) and are distributed in a cross-flow configuration. The thermal, mechanical and radiation effects resulting from the impact of a 2 GeV proton pulse are analysed in detail as well as an evaluation of the inventory of spallation products. The current design is found to conform to specifications and found to be robust enough to deal with several accident scenarios.

  17. Design specification for the European Spallation Source neutron generating target element

    Energy Technology Data Exchange (ETDEWEB)

    Aguilar, A. [Consorcio ESS-BILBAO. Parque Tecnológico Bizkaia. Poligono Ugaldeguren III, Pol. A, 7B, 48170 Zamudio (Spain); Sordo, F., E-mail: fernando.sordo@essbilbao.org [Consorcio ESS-BILBAO. Parque Tecnológico Bizkaia. Poligono Ugaldeguren III, Pol. A, 7B, 48170 Zamudio (Spain); Instituto de Fusión Nuclear, José Gutiérrez Abascal, 2, 28006 Madrid (Spain); Mora, T. [Consorcio ESS-BILBAO. Parque Tecnológico Bizkaia. Poligono Ugaldeguren III, Pol. A, 7B, 48170 Zamudio (Spain); Mena, L. [Consorcio ESS-BILBAO. Parque Tecnológico Bizkaia. Poligono Ugaldeguren III, Pol. A, 7B, 48170 Zamudio (Spain); Instituto de Fusión Nuclear, José Gutiérrez Abascal, 2, 28006 Madrid (Spain); Mancisidor, M.; Aguilar, J.; Bakedano, G.; Herranz, I.; Luna, P. [Consorcio ESS-BILBAO. Parque Tecnológico Bizkaia. Poligono Ugaldeguren III, Pol. A, 7B, 48170 Zamudio (Spain); Magan, M.; Vivanco, R. [Consorcio ESS-BILBAO. Parque Tecnológico Bizkaia. Poligono Ugaldeguren III, Pol. A, 7B, 48170 Zamudio (Spain); Instituto de Fusión Nuclear, José Gutiérrez Abascal, 2, 28006 Madrid (Spain); Jimenez-Villacorta, F. [Consorcio ESS-BILBAO. Parque Tecnológico Bizkaia. Poligono Ugaldeguren III, Pol. A, 7B, 48170 Zamudio (Spain); Sjogreen, K.; Oden, U. [European Spallation Source ERIC, P.O Box 176, SE-221 00 Lund (Sweden); Perlado, J.M. [Instituto de Fusión Nuclear, José Gutiérrez Abascal, 2, 28006 Madrid (Spain); and others

    2017-06-01

    The paper addresses some of the most relevant issues concerning the thermal hydraulics and radiation damage of the neutron generation target to be built at the European Spallation Source as recently approved after a critical design review. The target unit consists of a set of Tungsten blocks placed inside a wheel of 2.5 m diameter which rotates at some 0.5 Hz in order to distribute the heat generated from incoming protons which reach the target in the radial direction. The spallation material elements are composed of an array of Tungsten pieces which rest on a rotating steel support (the cassette) and are distributed in a cross-flow configuration. The thermal, mechanical and radiation effects resulting from the impact of a 2 GeV proton pulse are analysed in detail as well as an evaluation of the inventory of spallation products. The current design is found to conform to specifications and found to be robust enough to deal with several accident scenarios.

  18. Targeted MRI-guided prostate biopsy: are two biopsy cores per MRI-lesion required?

    Energy Technology Data Exchange (ETDEWEB)

    Schimmoeller, L.; Quentin, M.; Blondin, D.; Dietzel, F.; Schleich, C.; Thomas, C.; Antoch, G. [University Dusseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology, Dusseldorf (Germany); Hiester, A.; Rabenalt, R.; Albers, P.; Arsov, C. [University Dusseldorf, Medical Faculty, Department of Urology, Dusseldorf (Germany); Gabbert, H.E. [University Dusseldorf, Medical Faculty, Department of Pathology, Dusseldorf (Germany)

    2016-11-15

    This study evaluates the feasibility of performing less than two core biopsies per MRI-lesion when performing targeted MR-guided in-bore prostate biopsy. Retrospectively evaluated were 1545 biopsy cores of 774 intraprostatic lesions (two cores per lesion) in 290 patients (66 ± 7.8 years; median PSA 8.2 ng/ml) regarding prostate cancer (PCa) detection, Gleason score, and tumor infiltration of the first (FBC) compared to the second biopsy core (SBC). Biopsies were acquired under in-bore MR-guidance. For the biopsy cores, 491 were PCa positive, 239 of 774 (31 %) were FBC and 252 of 771 (33 %) were SBC (p = 0.4). Patient PCa detection rate based on the FBC vs. SBC were 46 % vs. 48 % (p = 0.6). For clinically significant PCa (Gleason score ≥4 + 3 = 7) the detection rate was 18 % for both, FBC and SBC (p = 0.9). Six hundred and eighty-seven SBC (89 %) showed no histologic difference. On the lesion level, 40 SBC detected PCa with negative FBC (7.5 %). Twenty SBC showed a Gleason upgrade from 3 + 3 = 6 to ≥3 + 4 = 7 (2.6 %) and 4 to ≥4 + 3 = 7 (0.5 %). The benefit of a second targeted biopsy core per suspicious MRI-lesion is likely minor, especially regarding PCa detection rate and significant Gleason upgrading. Therefore, a further reduction of biopsy cores is reasonable when performing a targeted MR-guided in-bore prostate biopsy. (orig.)

  19. Targeted MRI-guided prostate biopsy: are two biopsy cores per MRI-lesion required?

    International Nuclear Information System (INIS)

    Schimmoeller, L.; Quentin, M.; Blondin, D.; Dietzel, F.; Schleich, C.; Thomas, C.; Antoch, G.; Hiester, A.; Rabenalt, R.; Albers, P.; Arsov, C.; Gabbert, H.E.

    2016-01-01

    This study evaluates the feasibility of performing less than two core biopsies per MRI-lesion when performing targeted MR-guided in-bore prostate biopsy. Retrospectively evaluated were 1545 biopsy cores of 774 intraprostatic lesions (two cores per lesion) in 290 patients (66 ± 7.8 years; median PSA 8.2 ng/ml) regarding prostate cancer (PCa) detection, Gleason score, and tumor infiltration of the first (FBC) compared to the second biopsy core (SBC). Biopsies were acquired under in-bore MR-guidance. For the biopsy cores, 491 were PCa positive, 239 of 774 (31 %) were FBC and 252 of 771 (33 %) were SBC (p = 0.4). Patient PCa detection rate based on the FBC vs. SBC were 46 % vs. 48 % (p = 0.6). For clinically significant PCa (Gleason score ≥4 + 3 = 7) the detection rate was 18 % for both, FBC and SBC (p = 0.9). Six hundred and eighty-seven SBC (89 %) showed no histologic difference. On the lesion level, 40 SBC detected PCa with negative FBC (7.5 %). Twenty SBC showed a Gleason upgrade from 3 + 3 = 6 to ≥3 + 4 = 7 (2.6 %) and 4 to ≥4 + 3 = 7 (0.5 %). The benefit of a second targeted biopsy core per suspicious MRI-lesion is likely minor, especially regarding PCa detection rate and significant Gleason upgrading. Therefore, a further reduction of biopsy cores is reasonable when performing a targeted MR-guided in-bore prostate biopsy. (orig.)

  20. Approaches in the design of 99mTc based peptide radiolabelling for tumour targeting

    International Nuclear Information System (INIS)

    Yokoyama, A.; Horiuchi, K.; Arano, Y.

    2001-01-01

    . Neogalactoalbumin (NGA), a specific protein that was incorporated by hepatic parenchymal cell via receptor-mediated endocytosis immediately after administration, was selected as a biological tool. The fate of the radiolabelled NGA after lysosomal proteolysis in hepatocytes was studied in liver homogenates. Subcellular distribution and identification of radiometabolites were performed using multiple analytical methods such as electrophoresis, TLC, and size exclusion and reverse phase HPLC. The data indicated that the chemical bonding between 99m Tc and HYNIC remains stable in the lysosomes but the persistent liver localization was due to a radiometabolite identified as 99m Tc-HYNIC-lysine (tricine)2, demonstrated by the similar HPLC data obtained with the synthesized and radiolabelled metabolite. Better co-ligands or new ligands or new design of the peptides are required in order to reduce the residence time of radioactivity in non-target tissue for future peptide use in radiodiagnosis or radiotherapy. (author)

  1. [siRNAs with high specificity to the target: a systematic design by CRM algorithm].

    Science.gov (United States)

    Alsheddi, T; Vasin, L; Meduri, R; Randhawa, M; Glazko, G; Baranova, A

    2008-01-01

    'Off-target' silencing effect hinders the development of siRNA-based therapeutic and research applications. Common solution to this problem is an employment of the BLAST that may miss significant alignments or an exhaustive Smith-Waterman algorithm that is very time-consuming. We have developed a Comprehensive Redundancy Minimizer (CRM) approach for mapping all unique sequences ("targets") 9-to-15 nt in size within large sets of sequences (e.g. transcriptomes). CRM outputs a list of potential siRNA candidates for every transcript of the particular species. These candidates could be further analyzed by traditional "set-of-rules" types of siRNA designing tools. For human, 91% of transcripts are covered by candidate siRNAs with kernel targets of N = 15. We tested our approach on the collection of previously described experimentally assessed siRNAs and found that the correlation between efficacy and presence in CRM-approved set is significant (r = 0.215, p-value = 0.0001). An interactive database that contains a precompiled set of all human siRNA candidates with minimized redundancy is available at http://129.174.194.243. Application of the CRM-based filtering minimizes potential "off-target" silencing effects and could improve routine siRNA applications.

  2. Progress in bipolar disorder drug design toward the development of novel therapeutic targets: a clinician's perspective.

    Science.gov (United States)

    Fornaro, Michele; Kardash, Lubna; Novello, Stefano; Fusco, Andrea; Anastasia, Annalisa; De Berardis, Domenico; Perna, Giampaolo; Carta, Mauro Giovanni

    2018-03-01

    Bipolar disorder (BD) is a considerable burden to the affected individual. The need for novel drug targets and improved drug design (DD) in BD is therefore clear. Areas covered: The following article provides a brief, narrative, clinician-oriented overview of the most promising novel pharmacological targets for BD along with a concise overview regarding the general DD process and the unmet needs relevant to BD. Expert opinion: A number of novel potential drug targets have been investigated. With the notable exception of the kynurenine pathway, available evidence is too scarce to highlight a definitive roadmap for forthcoming DD in BD. BD itself may present with different facets, as it is a polymorphic clinical spectrum. Therefore, promoting clinical-case stratification should be based on precision medicine, rather than on novel biological targets. Furthermore, the full release of raw study data to the scientific community and the development of uniform clinical trial standards (including more realistic outcomes) should be promoted to facilitate the DD process in BD.

  3. Evaluation and decision of products conceptual design schemes based on customer requirements

    International Nuclear Information System (INIS)

    Huang, Hong Zhong; Li, Yan Feng; Liu, Yu; Wang, Zhonglai; Liu, Wenhai

    2011-01-01

    Within the competitive market environment, understanding customer requirements is crucial for all corporations to obtain market share and survive competition. Only the products exactly meeting customer requirements can win in the market place. Therefore, customer requirements play a very important role in the evaluation and decision process of conceptual design schemes of products. In this paper, an evaluation and decision method based on customer requirements is presented. It utilizes the importance of customer requirements, the satisfaction degree of each evaluation metric to the specification, and an evaluation metric which models customer requirements to evaluate the satisfaction degree of each design scheme to specific customer requirements via the proposed BP neural networks. In the evaluation and decision process, fuzzy sets are used to describe the importance of customer requirements, the relationship between customer requirements and evaluation metrics, the satisfaction degree of each scheme to customer requirements, and the crisp set is used to describe the satisfaction degree of each metric to specifications. The effectiveness of the proposed method is demonstrated by an example of front suspension fork design of mountain bikes

  4. Evaluation and decision of products conceptual design schemes based on customer requirements

    Energy Technology Data Exchange (ETDEWEB)

    Huang, Hong Zhong; Li, Yan Feng; Liu, Yu; Wang, Zhonglai [University of Electronic Science and Technology of China, Sichuan (China); Liu, Wenhai [2China Science Patent Trademark Agents Ltd., Beijing (China)

    2011-09-15

    Within the competitive market environment, understanding customer requirements is crucial for all corporations to obtain market share and survive competition. Only the products exactly meeting customer requirements can win in the market place. Therefore, customer requirements play a very important role in the evaluation and decision process of conceptual design schemes of products. In this paper, an evaluation and decision method based on customer requirements is presented. It utilizes the importance of customer requirements, the satisfaction degree of each evaluation metric to the specification, and an evaluation metric which models customer requirements to evaluate the satisfaction degree of each design scheme to specific customer requirements via the proposed BP neural networks. In the evaluation and decision process, fuzzy sets are used to describe the importance of customer requirements, the relationship between customer requirements and evaluation metrics, the satisfaction degree of each scheme to customer requirements, and the crisp set is used to describe the satisfaction degree of each metric to specifications. The effectiveness of the proposed method is demonstrated by an example of front suspension fork design of mountain bikes.

  5. Supplmental design requirements document enhanced radioactive and mixed waste storage: Phase 5, Project W-113

    International Nuclear Information System (INIS)

    Ocampo, V.P.

    1994-11-01

    This Supplemental Design Requirements Document (SDRD) is used to communicate Project W-113 specific plant design information from Westinghouse Hanford Company (WHC) to the United States Department of Energy (DOE) and the cognizant Architect Engineer (A/E). The SDRD is prepared after the completion of the project Conceptual Design report (CDR) and prior to the initiation of definitive design. Information in the SDRD serves two purposes: to convey design requirements that are too detailed for inclusion in the Functional Design Criteria (FDC) report and to serve as a means of change control for design commitments in the Title I and Title II design. The Solid Waste Retrieval Project (W-113) SDRD has been restructured from the equipment based outline used in previous SDRDs to a functional systems outline. This was done to facilitate identification of deficiencies in the information provided in the initial draft SDRD and aid design confirmation. The format and content of this SDRD adhere as closely as practicable to the requirements of WHC-CM-6-1, Standard Engineering Practices for Functional Design Criteria

  6. SU-E-T-244: Designing Low-Z Targets To Enhance Surface Dose: A Monte Carlo Simulation

    Energy Technology Data Exchange (ETDEWEB)

    Kelly, R [Nova Scotia Cancer Centre, Halifax, NS (Canada); Robar, J [Capital District Health Authority, Halifax, NS (Canada); Parsons, D [Dalhousie University, Halifax, Nova Scotia (Canada)

    2015-06-15

    Purpose: Recent developments in The Varian Truebeam linac platform allows for the introduction of low-Z targets into the beam line for the imaging purposes. We have proposed using a low-Z target for radiation therapy purposes to enhance the surface dose during radiation treatment. The target arm of the Varian Truebeam accelerator consists of multiple targets with are linearly translated into the beam line. We have designed two Low-Z targets made of carbon: 1) a step target consisting of three steps of 15%, 30% and 60% CSDA range for 2.5 MeV electrons Figure 1a; 2) and a ramp target, an incline plane 2cm long with thicknesses ranging from 0% to 60% CSDA range, Figure 1b. The purpose of this work will determine the spectral characteristics of these target designs and determine if they have practical clinical applications for enhancing surface dose. Methods: To calculate the spectral characteristics of these targets, a standard Monte Carlo model of a Varian Clinac accelerator was used. Simulations were performed with a carbon step target, and a carbon ramp target, located at the same position as the electron foil in the rotating carousel. Simulations were carried out using a 2.5 MeV electron beam. Results: The step target design produced spectral characteristics which were similar to spectral model using a single disk target of the same thickness. The ramp target provides a means to have positional variation of the spectral components of the beam, however, the electron component as 60% CSDA us much broader than the step target. Conclusion: The carbon step-target provides a spectral distribution which is similar to a carbon disk of comparable thickness. The spectral distribution from the ramp-target can be modified as a function of position to provide a wide range of low energy electrons for surface dose enhancement.

  7. Meeting Human Reliability Requirements through Human Factors Design, Testing, and Modeling

    Energy Technology Data Exchange (ETDEWEB)

    R. L. Boring

    2007-06-01

    In the design of novel systems, it is important for the human factors engineer to work in parallel with the human reliability analyst to arrive at the safest achievable design that meets design team safety goals and certification or regulatory requirements. This paper introduces the System Development Safety Triptych, a checklist of considerations for the interplay of human factors and human reliability through design, testing, and modeling in product development. This paper also explores three phases of safe system development, corresponding to the conception, design, and implementation of a system.

  8. Lujan Center Mark-IV Target Neutronics Design Internal Review Report

    Energy Technology Data Exchange (ETDEWEB)

    Lisowski, Paul W. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Gallmeier, Franz [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Guber, Klaus [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2018-02-26

    The 1L Target Moderator Reflector System (TMRS) at the Lujan Center will need to be replaced before the CY 2020 operating cycle. A Physics Division design team investigated options for improving the overall target performance for nuclear science research with minimal reduction in performance for materials science. This review concluded that devoting an optimized arrangement of the Lujan TMRS upper tier to nuclear science and using the lower tier for materials science can achieve those goals. This would open the opportunity for enhanced nuclear science research in an important neutron energy range for NNSA. There will be no other facility in the US that will compete in the keV energy range provided flight paths and instrumentation are developed to take advantage of the neutron flux and resolution.

  9. Target Channel Visiting Order Design Using Particle Swarm Optimization for Spectrum Handoff in Cognitive Radio Networks

    Directory of Open Access Journals (Sweden)

    Shilian Zheng

    2014-08-01

    Full Text Available In a dynamic spectrum access network, when a primary user (licensed user reappears on the current channel, cognitive radios (CRs need to vacate the channel and reestablish a communications link on some other channel to avoid interference to primary users, resulting in spectrum handoff. This paper studies the problem of designing target channel visiting order for spectrum handoff to minimize expected spectrum handoff delay. A particle swarm optimization (PSO based algorithm is proposed to solve the problem. Simulation results show that the proposed algorithm performs far better than random target channel visiting scheme. The solutions obtained by PSO are very close to the optimal solution which further validates the effectiveness of the proposed method.

  10. 29 CFR 1910.36 - Design and construction requirements for exit routes.

    Science.gov (United States)

    2010-07-01

    ... construction requirements for exit routes. (a) Basic requirements. Exit routes must meet the following design... your workplace, consult NFPA 101-2000, Life Safety Code. (c) Exit discharge. (1) Each exit discharge... route must be adequate. (1) Exit routes must support the maximum permitted occupant load for each floor...

  11. Targeting of a Nicotiana plumbaginifolia H+ -ATPase to the plasma membrane is not by default and requires cytosolic structural determinants.

    Science.gov (United States)

    Lefebvre, Benoit; Batoko, Henri; Duby, Geoffrey; Boutry, Marc

    2004-07-01

    The structural determinants involved in the targeting of multitransmembrane-span proteins to the plasma membrane (PM) remain poorly understood. The plasma membrane H+ -ATPase (PMA) from Nicotiana plumbaginifolia, a well-characterized 10 transmembrane-span enzyme, was used as a model to identify structural elements essential for targeting to the PM. When PMA2 and PMA4, representatives of the two main PMA subfamilies, were fused to green fluorescent protein (GFP), the chimeras were shown to be still functional and to be correctly and rapidly targeted to the PM in transgenic tobacco. By contrast, chimeric proteins containing various combinations of PMA transmembrane spanning domains accumulated in the Golgi apparatus and not in the PM and displayed slow traffic properties through the secretory pathway. Individual deletion of three of the four cytosolic domains did not prevent PM targeting, but deletion of the large loop or of its nucleotide binding domain resulted in GFP fluorescence accumulating exclusively in the endoplasmic reticulum. The results show that, at least for this polytopic protein, the PM is not the default pathway and that, in contrast with single-pass membrane proteins, cytosolic structural determinants are required for correct targeting.

  12. Design of a modular digital computer system, DRL 4. [for meeting future requirements of spaceborne computers

    Science.gov (United States)

    1972-01-01

    The design is reported of an advanced modular computer system designated the Automatically Reconfigurable Modular Multiprocessor System, which anticipates requirements for higher computing capacity and reliability for future spaceborne computers. Subjects discussed include: an overview of the architecture, mission analysis, synchronous and nonsynchronous scheduling control, reliability, and data transmission.

  13. 30 CFR 77.804 - High-voltage trailing cables; minimum design requirements.

    Science.gov (United States)

    2010-07-01

    ... OF UNDERGROUND COAL MINES Surface High-Voltage Distribution § 77.804 High-voltage trailing cables; minimum design requirements. (a) High-voltage trailing cables used in resistance grounded systems shall be... 30 Mineral Resources 1 2010-07-01 2010-07-01 false High-voltage trailing cables; minimum design...

  14. 75 FR 80571 - Core Principles and Other Requirements for Designated Contract Markets

    Science.gov (United States)

    2010-12-22

    ... Part II Commodity Futures Trading Commission 17 CFR Parts 1, 16, and 38 Core Principles and Other... CFR Parts 1, 16, and 38 RIN 3038-AD09 Core Principles and Other Requirements for Designated Contract... Principles 1. Subpart B--Designation as Contract Market 2. Subpart C--Compliance With Rules i. Proposed Sec...

  15. Requirements for high level models supporting design space exploration in model-based systems engineering

    NARCIS (Netherlands)

    Haveman, Steven; Bonnema, Gerrit Maarten

    2013-01-01

    Most formal models are used in detailed design and focus on a single domain. Few effective approaches exist that can effectively tie these lower level models to a high level system model during design space exploration. This complicates the validation of high level system requirements during

  16. Man/machine interface for a nuclear cask remote handling control station: system design requirements

    International Nuclear Information System (INIS)

    Clarke, M.M.; Kreifeldt, J.G.; Draper, J.V.

    1984-01-01

    Design requirements are presented for a control station of a proposed semi-automated facility for remote handling of nuclear waste casks. Functional and operational man/machine interface: controls, displays, software format, station architecture, and work environment. In addition, some input is given to the design of remote sensing systems in the cask handling areas. 18 references, 9 figures, 12 tables

  17. Technical report of comparison in design control on R and D and industrial quality requirements

    International Nuclear Information System (INIS)

    Kim, Kwan Hyun

    2000-06-01

    This technical report provides the methods on how to establish the requirements on nuclear R and D facilities. This report applies to the quality assurance(QA) programmes of the design, fabrication in research reactor. The organization having overall responsibility for the nuclear power item design, preservation, fabrication shall be described in this report in each stage of nuclear project

  18. Heterogeneity in head and neck IMRT target design and clinical practice

    International Nuclear Information System (INIS)

    Hong, Theodore S.; Tomé, Wolfgang A.; Harari, Paul M.

    2012-01-01

    Purpose: To assess patterns of H and N IMRT practice with particular emphasis on elective target delineation. Materials and methods: Twenty institutions with established H and N IMRT expertise were solicited to design clinical target volumes for the identical H and N cancer case. To limit contouring variability, a primary tonsil GTV and ipsilateral level II node were pre-contoured. Participants were asked to accept this GTV, and contour their recommended CTV and PTV. Dose prescriptions, contouring time, and recommendations regarding chemotherapy were solicited. Results: All 20 institutions responded. Remarkable heterogeneity in H and N IMRT design and practice was identified. Seventeen of 20 centers recommended treatment of bilateral necks whereas 3/20 recommended treatment of the ipsilateral neck only. The average CTV volume was 250 cm 3 (range 37–676 cm 3 ). Although there was high concordance in coverage of ipsilateral neck levels II and III, substantial variation was identified for levels I, V, and the contralateral neck. Average CTV expansion was 4.1 mm (range 0–15 mm). Eight of 20 centers recommended chemotherapy (cisplatin), whereas 12/20 recommended radiation alone. Responders prescribed on average 69 and 68 Gy to the tumor and metastatic node GTV, respectively. Average H and N target volume contouring time was 102.5 min (range 60–210 min). Conclusion: This study identifies substantial heterogeneity in H and N IMRT target definition, prescription, neck treatment, and use of chemotherapy among practitioners with established H and N IMRT expertise. These data suggest that continued efforts to standardize and simplify the H and N IMRT process are desirable for the safe and effective global advancement of H and N IMRT practice.

  19. Designing eHealth that Matters via a Multidisciplinary Requirements Development Approach.

    Science.gov (United States)

    Van Velsen, Lex; Wentzel, Jobke; Van Gemert-Pijnen, Julia Ewc

    2013-06-24

    Requirements development is a crucial part of eHealth design. It entails all the activities devoted to requirements identification, the communication of requirements to other developers, and their evaluation. Currently, a requirements development approach geared towards the specifics of the eHealth domain is lacking. This is likely to result in a mismatch between the developed technology and end user characteristics, physical surroundings, and the organizational context of use. It also makes it hard to judge the quality of eHealth design, since it makes it difficult to gear evaluations of eHealth to the main goals it is supposed to serve. In order to facilitate the creation of eHealth that matters, we present a practical, multidisciplinary requirements development approach which is embedded in a holistic design approach for eHealth (the Center for eHealth Research roadmap) that incorporates both human-centered design and business modeling. Our requirements development approach consists of five phases. In the first, preparatory, phase the project team is composed and the overall goal(s) of the eHealth intervention are decided upon. Second, primary end users and other stakeholders are identified by means of audience segmentation techniques and our stakeholder identification method. Third, the designated context of use is mapped and end users are profiled by means of requirements elicitation methods (eg, interviews, focus groups, or observations). Fourth, stakeholder values and eHealth intervention requirements are distilled from data transcripts, which leads to phase five, in which requirements are communicated to other developers using a requirements notation template we developed specifically for the context of eHealth technologies. The end result of our requirements development approach for eHealth interventions is a design document which includes functional and non-functional requirements, a list of stakeholder values, and end user profiles in the form of

  20. Evolution of facility layout requirements and CAD [computer-aided design] system development

    International Nuclear Information System (INIS)

    Jones, M.

    1990-06-01

    The overall configuration of the Superconducting Super Collider (SSC) including the infrastructure and land boundary requirements were developed using a computer-aided design (CAD) system. The evolution of the facility layout requirements and the use of the CAD system are discussed. The emphasis has been on minimizing the amount of input required and maximizing the speed by which the output may be obtained. The computer system used to store the data is also described