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Sample records for des analogues archeologiques

  1. The use of natural and archaeological analogues for understanding the long-term behavior of nuclear glasses; L'utilisation des analogues naturels et archeologiques pour la comprehension de l'evolution a long terme des verres nucleaires

    Energy Technology Data Exchange (ETDEWEB)

    Libourel, G.; Verney-Carron, A.; Morlok, A. [CNRS UPR2300, centre de recherches petrographiques et geochimiques (CRPG), Nancy-universite, 15, rue Notre-Dame-des-Pauvres, BP 20, 54501 Vandoeuvre-les-Nancy (France); Libourel, G. [INPL, Ecole nationale superieure de geologie (ENSG), Nancy-universite, rue du Doyen-Marcel-Roubault, BP 20, 54501 Vandoeuvre-les-Nancy (France); Gin, St. [CEA Marcoule, DEN/SECM/LCLT, 30 (France); Sterpenich, J. [G2R, CNRS-UMR 7566, Nancy-universite, BP 70239, 54506 Vandoeuvre-les-Nancy cedex (France); Michelin, A.; Neff, D.; Dillmann, Ph. [Laboratoire archeomateriaux et prevision de l' alteration LAPA/SIS2 M, CEA and CNRS, Bat 637, CEA Saclay, 91191 Gif/Yvette cedex (France); Michelin, A.; Dillmann, Ph. [LMC IRAMAT UMR5060 CNRS (France)

    2011-02-15

    The knowledge of the long-term behavior of nuclear waste in anticipation of ultimate disposal in a deep geological formation is of prime importance in a waste management strategy. If phenomenological models have been developed to predict the long-term behavior of these materials, validating these models remains a challenge, when considering the time scale of radioactive decay of radionuclides of environmental concern, typically 10{sup 4}-10{sup 5} yrs. Here we show how natural or archaeological analogues provide critical constraints not only on the phenomenology of glass alteration and the mechanisms involved, but also on the ability of experimental short-term data to predict long-term alteration in complex environments. (authors)

  2. Archaeological analogs and corrosion; Analogues archeologiques et corrosion

    Energy Technology Data Exchange (ETDEWEB)

    David, D

    2008-07-01

    In the framework of the high level and long life radioactive wastes disposal deep underground, the ANDRA built a research program on the material corrosion. In particular they aim to design containers for a very long time storage. Laboratory experiments are in progress and can be completed by the analysis of metallic archaeological objects and their corrosion after hundred years. (A.L.B.)

  3. Study of archaeological analogs for the validation of nuclear glass long-term behavior models; Etude d'analogues archeologiques pour la validation des modeles de comportement a long terme des verres nucleaires

    Energy Technology Data Exchange (ETDEWEB)

    Verney-Carron, A

    2008-10-15

    Fractured archaeological glass blocks collected from a shipwreck discovered in the Mediterranean Sea near Embiez Island (Var) were investigated because of their morphological analogy with vitrified nuclear waste and of a known and stable environment. These glasses are fractured due to a fast cooling after they were melted (like nuclear glass) and have been altered for 1800 years in seawater. This work results in the development and the validation of a geochemical model able to simulate the alteration of a fractured archaeological glass block over 1800 years. The kinetics associated with the different mechanisms (interdiffusion and dissolution) and the thermodynamic parameters of the model were determined by leaching experiments. The model implemented in HYTEC software was used to simulate crack alteration over 1800 years. The consistency between simulated alteration thicknesses and measured data on glass blocks validate the capacity of the model to predict long-term alteration. This model is able to account for the results from the characterization of crack network and its state of alteration. The cracks in the border zone are the most altered due to a fast renewal of the leaching solution, whereas internal cracks are thin because of complex interactions between glass alteration and transport of elements in solution (influence of initial crack aperture and of the crack sealing). The lowest alteration thicknesses, as well as their variability, can be explained. The analog behavior of archaeological and nuclear glasses from leaching experiments makes possible the transposition of the model to nuclear glass in geological repository. (author00.

  4. Contribution of archaeological analogs to the estimation of average corrosion rates and long term corrosion mechanisms of low carbon steel in soil; Apport des analogues archeologiques a l'estimation des vitesses moyennes et a l'etude des mecanismes de corrosion a tres long terme des aciers non allies dans les sols

    Energy Technology Data Exchange (ETDEWEB)

    Neff, D

    2003-11-15

    In the context of the French nuclear waste storage, a multi-barriers disposal is envisaged. Wastes could be put in metallic overpacks disposed in a clay soil. As these overpacks could be made of low carbon steel, it is important to understand the corrosion behaviour of this material in soil during period of several centuries. Indeed, it is necessary to consolidate the empirical data by a phenomenological approach. This includes laboratory experiments and modelling of the phenomenon which have to be validated and completed by the study of archaeological artefacts. This was the aim of this PhD-work. To this purpose, an analytical protocol has been elaborated: about forty archaeological artefacts coming from five dated sites (2. to 16. centuries) have been studied on cross section in order to observe on the same sample all the constituents of the system: metallic substrate/corrosion products/environment. The corrosion products are divided into two zones: the Dense Product Layer (DPL) in contact with the metal, and the Transformed Medium (TM) which are the corrosion products formed around soil minerals (quartz grains). The metallic substrate has been studied by the classical methods of materials science (optical and scanning electron microscope, energy and wavelength dispersive spectroscopies). It has been verified that despite their heterogeneity of structure and composition, they are all hypo-eutectoids steels that can contain phosphorous until 0.5 wt%. The corrosion products have been analysed by local structural analytical methods as micro-diffraction under synchrotron radiation ({mu}XRD) and Raman micro-spectroscopy. These two complementary techniques and also the elemental composition analysis conducted to the characterisation of the corrosion forms. On the majority of the samples coming from four sites, the DPL are constituted by goethite including marbles of magnetite/maghemite. On the artefacts from the fifth site, a particular corrosion form has been identified. This corrosion form, constituted among others by a siderite layer is due to a particular environment: waterlogged soil containing wood. In the whole, analyses conducted in the TM show that it is composed of goethite badly crystallized in comparison with those of the DPL. Moreover, in this zone, the average elemental iron amount decreases progressively from the metal to the soil in which it stabilizes. In order to know the behaviour of the identified phases in soil water, some thermodynamic data have been involved to calculate their solubility in function of pH, potential and various water composition. The first conclusion concerns the influence of the composition and the structure of the material which is not important for the corrosion behaviour. From the results, some hypothesis have been formulated on the long term corrosion mechanisms of hypo-eutectoids steels in the considered environment. The role of the cracks formed in the DPL during the burial was evidenced. Moreover, these corrosion products undertake a dissolution in the soil water and a reprecipitation, explaining the progressive decrease of the iron amount in the TM. Lastly, some average corrosion rates have been measured with the help of the analytical and thermodynamic results: they do not exceed 4 {mu}m/year. (author)

  5. Analogue Gravity

    Directory of Open Access Journals (Sweden)

    Barceló Carlos

    2005-12-01

    Full Text Available Analogue models of (and for gravity have a long and distinguished history dating back to the earliest years of general relativity. In this review article we will discuss the history, aims, results, and future prospects for the various analogue models. We start the discussion by presenting a particularly simple example of an analogue model, before exploring the rich history and complex tapestry of models discussed in the literature. The last decade in particular has seen a remarkable and sustained development of analogue gravity ideas, leading to some hundreds of published articles, a workshop, two books, and this review article. Future prospects for the analogue gravity programme also look promising, both on the experimental front (where technology is rapidly advancing and on the theoretical front (where variants of analogue models can be used as a springboard for radical attacks on the problem of quantum gravity.

  6. Contributions de la geographie et de la modelisation predictive a une etude de potentiel archeologique prehistorique en Gaspesie

    Science.gov (United States)

    Desrosiers, Marc

    La Gaspésie, région péninsulaire à l'extrême est du Québec, possède un héritage archéologique préhistorique riche qui s'étend de 9 000 ans jusqu'à 450 ans avant aujourd'hui. L'archéologie a livré de nombreux sites préhistoriques dans la région, surtout dans le nord de la péninsule, un constat en partie attribuable à la présence de sources de matières premières lithiques, d'axes de circulation potentielles, mais aussi à la répartition spatiale inégale des efforts de recherche. L'étude du potentiel archéologique préhistorique gaspésien, c'est la première étape de la démarche archéologique, est donc nécessaire pour orienter les travaux futurs dans cette région. Trois secteurs représentatifs de la Gaspésie ont été étudiés pour développer une nouvelle approche d'étude de potentiel : Sainte-Anne-des-Monts, le lac Sainte-Anne et New Richmond. Ensemble, ces secteurs s'étirent au travers de la péninsule sur un axe nord-sud et correspondent à un possible axe de circulation préhistorique. L'évaluation du potentiel archéologique de ces aires d'étude dépend notamment de contexte géographique gaspésien. Celui-ci est complexe, particulièrement depuis la déglaciation qui a engendré une succession de transformations du paysage. Les variations du niveau marin relatif, le passage de la toundra à un milieu forestier et d'autres changements environnementaux ont conditionné la façon dont les populations préhistoriques se sont adaptées au territoire. L'étude de potentiel dépend également des connaissances archéologiques existantes pour la région, car elles conditionnent la sélection de variables environnementales représentatives des sites connus. À partir de la confrontation des données géographiques et archéologiques, nous avons proposé des schèmes d'établissement pour les périodes chronoculturelles de la préhistoire gaspésienne. Ces patrons informationnels permettent d'illustrer la façon dont les populations

  7. Analogue Gravity

    Directory of Open Access Journals (Sweden)

    Carlos Barceló

    2011-05-01

    Full Text Available Analogue gravity is a research programme which investigates analogues of general relativistic gravitational fields within other physical systems, typically but not exclusively condensed matter systems, with the aim of gaining new insights into their corresponding problems. Analogue models of (and for gravity have a long and distinguished history dating back to the earliest years of general relativity. In this review article we will discuss the history, aims, results, and future prospects for the various analogue models. We start the discussion by presenting a particularly simple example of an analogue model, before exploring the rich history and complex tapestry of models discussed in the literature. The last decade in particular has seen a remarkable and sustained development of analogue gravity ideas, leading to some hundreds of published articles, a workshop, two books, and this review article. Future prospects for the analogue gravity programme also look promising, both on the experimental front (where technology is rapidly advancing and on the theoretical front (where variants of analogue models can be used as a springboard for radical attacks on the problem of quantum gravity.

  8. BALANOL ANALOGUES

    DEFF Research Database (Denmark)

    1997-01-01

    The present invention relates to a solid phase methodology for the preparation of a combinatorial library of structural analogues of the natural product balanol (ophiocordin, azepinostatin), which is a protein kinase C (PKC) and protein kinase A (PKA) inhibitor. The method comprises solid...

  9. Analogue computing methods

    CERN Document Server

    Welbourne, D

    1965-01-01

    Analogue Computing Methods presents the field of analogue computation and simulation in a compact and convenient form, providing an outline of models and analogues that have been produced to solve physical problems for the engineer and how to use and program the electronic analogue computer. This book consists of six chapters. The first chapter provides an introduction to analogue computation and discusses certain mathematical techniques. The electronic equipment of an analogue computer is covered in Chapter 2, while its use to solve simple problems, including the method of scaling is elaborat

  10. Analogue MIMO Detection

    Directory of Open Access Journals (Sweden)

    McNamara Darren

    2006-01-01

    Full Text Available In this contribution we propose an analogue receiver that can perform turbo detection in MIMO systems. We present the case for a receiver that is built from nonlinear analogue devices, which perform detection in a "free-flow" network (no notion of iterations. This contribution can be viewed as an extension of analogue turbo decoder concepts to include MIMO detection. These first analogue implementations report reductions of few orders of magnitude in the number of required transistors and in consumed energy, and the same order of improvement in processing speed. It is anticipated that such analogue MIMO decoder could bring about the same advantages, when compared to traditional digital implementations.

  11. Des analogues naturels de sites de stockage de déchets nucléaires vieux de 2 milliards d'années : les réacteurs de fission nucléaire naturels du Gabon (Afrique)

    Science.gov (United States)

    Gauthier-Lafaye, François

    2002-10-01

    Two billion years ago, the increase of oxygen in atmosphere and the high 235U/ 238U uranium ratio (>3%) made possible the occurrence of natural nuclear reactors on Earth. These reactors are considered to be a good natural analogue for nuclear waste disposal. Their preservation during such a long period of time is mainly due to the geological stability of the site, the occurrence of clays surrounding the reactors and acting as an impermeable shield, and the occurrence of organic matter that maintained the environment in reducing conditions, favourable for the stability of uraninite. Hydrogeochemical studies and modelling have shown the complexity of the geochemical system at Oklo and Bangombé (Gabon) and the lack of precise data about uranium and fission products retention and migration mechanisms in geological environments. To cite this article: F. Gauthier-Lafaye, C. R. Physique 3 (2002) 839-849.

  12. Natural Analogue Synthesis Report

    Energy Technology Data Exchange (ETDEWEB)

    A. M. Simmons

    2002-05-01

    The purpose of this report is to present analogue studies and literature reviews designed to provide qualitative and quantitative information to test and provide added confidence in process models abstracted for performance assessment (PA) and model predictions pertinent to PA. This report provides updates to studies presented in the ''Yucca Mountain Site Description'' (CRWMS M and O 2000 [151945], Section 13) and new examples gleaned from the literature, along with results of quantitative studies conducted specifically for the Yucca Mountain Site Characterization Project (YMP). The intent of the natural analogue studies was to collect corroborative evidence from analogues to demonstrate additional understanding of processes expected to occur during postclosure at a potential Yucca Mountain repository. The report focuses on key processes by providing observations and analyses of natural and anthropogenic (human-induced) systems to improve understanding and confidence in the operation of these processes under conditions similar to those that could occur in a nuclear waste repository. The process models include those that represent both engineered and natural barrier processes. A second purpose of this report is to document the various applications of natural analogues to geologic repository programs, focusing primarily on the way analogues have been used by the YMP. This report is limited to providing support for PA in a confirmatory manner and to providing corroborative inputs for process modeling activities. Section 1.7 discusses additional limitations of this report. Key topics for this report are analogues to emplacement drift degradation, waste form degradation, waste package degradation, degradation of other materials proposed for the engineered barrier, seepage into drifts, radionuclide flow and transport in the unsaturated zone (UZ), analogues to coupled thermal-hydrologic-mechanical-chemical processes, saturated zone (SZ) transport

  13. NATURAL ANALOGUE SYNTHESIS REPORT

    International Nuclear Information System (INIS)

    Simmons, A.M.

    2004-01-01

    The purpose of this report is to present analogue studies and literature reviews designed to provide qualitative and quantitative information to test and provide added confidence in process models abstracted for performance assessment (PA) and model predictions pertinent to PA. This report provides updates to studies presented in the Yucca Mountain Site Description (CRWMS M and O 2000 [151945], Section 13) and new examples gleaned from the literature along with results of quantitative studies conducted specifically for the Yucca Mountain Project (YMP). The intent of the natural analogue studies was to collect corroborative evidence from analogues to demonstrate additional understanding of processes expected to occur during postclosure at a potential Yucca Mountain repository. The report focuses on key processes by providing observations and analyses of natural and anthropogenic (human-induced) systems to improve understanding and confidence in the operation of these processes under conditions similar to those that could occur in a nuclear waste repository. The process models include those that represent both engineered and natural barrier processes. A second purpose of this report is to document the various applications of natural analogues to geologic repository programs, focusing primarily on the way analogues have been used by the YMP. This report is limited to providing support for PA in a confirmatory manner and to providing corroborative inputs for process modeling activities. Section 1.7 discusses additional limitations of this report. Key topics for this report are analogues to emplacement-drift degradation, waste-form degradation, waste-package degradation, degradation of other materials proposed for the engineered barrier, seepage into drifts, radionuclide flow and transport in the unsaturated zone (UZ), analogues to coupled thermal-hydrologic-mechanical-chemical processes, saturated-zone (SZ) transport, impact of radionuclide release on the biosphere

  14. Contribution to the tectonic characterization of fractured reservoirs, I: photo-elasticimetric modelling of the stress perturbations near faults and the associated fracture network: application to oil reserves, II mechanisms for the 3D joint organization in a natural reservoir analogue (flat-lying Devonian Old Red Sandstones of Caitness in North Scotland); Contribution a la caracterisation tectonique des reservoirs fractures, I: modelisation photoelecticimetrique des perturbations de contrainte au voisinage des failles et de la fracturation associee: application petroliere, II: mecanismes de developpement en 3D des diaclases dans un analogue de reservoir, le Devonien tabulaire du caithness (Ecosse)

    Energy Technology Data Exchange (ETDEWEB)

    Auzias, V.

    1995-10-27

    In order to understand joint network organisation in oil reservoirs, as a first step we have adapted to technique (the photo-elasticimetry) to study stress fields in 2D. This method allows to determine the principal stress trajectories near faults, as well as the associated joint network organisation. Natural joint networks perturbed near faults are modeled and the parameters that control stress perturbation are proposed. With the aim of extrapolating joint data from a well to the entire reservoir our modelling is based on both 3 D seismic data and local joint data. The second part of our research was dedicated to studying joint propagation mechanisms in a natural reservoir analogue (flat-lying Devonian Old Red Sandstones of Caitness in North Scotland). Several exposure observation at different scales and in 3D (horizontal and cliff sections) allow to reconstitute the fracturing geometry from centimeter to kilometer scale and to link these to the regional tectonic history. This study shows that it is possible to differentiate three types of joints major joints, `classic` joints and micro-joints, each with different vertical persistence. New concepts on the 3D joint organisation have been deduced from field quantitative data, which can be applied to reservoir fracture modeling. In particular the non-coexistence phenomenon in a single bed of two regional joint sets with close strikes. Some joint development mechanisms are discussed: interaction between joints and sedimentary interfaces, joint distribution near faults, origin of en echelon arrays associated with joints. (author) 142 refs.

  15. CEC natural analogue working group

    International Nuclear Information System (INIS)

    Come, B.; Chapman, N.A.

    1986-01-01

    The second meeting of the CEC Natural Analogue Working Group took place on June 17-19, 1986, hosted by the Swiss NAGRA in Interlaken (CH). A review of recent progress in natural analogue programmes was carried out, and complemented by detailed discussions about geomicrobiology, archaeological analogues, natural colloids, and use of analogues to increase confidence in safety assessments for radioactive waste disposal. A statement drafted by the Group, and the presentations made, are put together in this report

  16. CEC Natural Analogue Working Group

    International Nuclear Information System (INIS)

    Come, B.; Chapman, N.A.

    1989-01-01

    The central theme for the third meeting of the CEC analogue working group was ''How can analogue data be used for performance assessments, both in support of the results and for presentation to the public''. This report puts together the most recent achievements in this field, together with a review of on-going natural analogue programmes

  17. Natural analogue working group

    International Nuclear Information System (INIS)

    Come, B.; Chapman, N.

    1986-01-01

    A Natural Analogue Working Group was established by the Commission of the European Communities in 1985. The purpose of this group is to bring together modellers with earth scientists and others, so that maximum benefit can be obtained from natural analogue studies with a view to safe geological disposal of radioactive waste. The first meeting of this group was held in Brussels from November 5 to 7, 1985. The discussions mainly concerned the identification of the modellers' needs and of the earth scientists' capacity to provide for them. Following the debates, a written statement was produced by the Group; this document forms the core of the present Report. Notes and outlines of many of the presentations made are grouped in four appendixes. The valuable contribution of all those involved in the meeting is gratefully acknowledged

  18. Quantum analogue computing.

    Science.gov (United States)

    Kendon, Vivien M; Nemoto, Kae; Munro, William J

    2010-08-13

    We briefly review what a quantum computer is, what it promises to do for us and why it is so hard to build one. Among the first applications anticipated to bear fruit is the quantum simulation of quantum systems. While most quantum computation is an extension of classical digital computation, quantum simulation differs fundamentally in how the data are encoded in the quantum computer. To perform a quantum simulation, the Hilbert space of the system to be simulated is mapped directly onto the Hilbert space of the (logical) qubits in the quantum computer. This type of direct correspondence is how data are encoded in a classical analogue computer. There is no binary encoding, and increasing precision becomes exponentially costly: an extra bit of precision doubles the size of the computer. This has important consequences for both the precision and error-correction requirements of quantum simulation, and significant open questions remain about its practicality. It also means that the quantum version of analogue computers, continuous-variable quantum computers, becomes an equally efficient architecture for quantum simulation. Lessons from past use of classical analogue computers can help us to build better quantum simulators in future.

  19. The Palmottu analogue project

    International Nuclear Information System (INIS)

    Ahonen, L.; Blomqvist, R.; Suksi, J.

    1993-01-01

    The report gives a summary of the results of investigations carried out in 1992 at the Palmottu natural analogue study site, which is a small U-Th mineralization in Nummi-Pusula, southwestern Finland. Additionally, the report includes several separate articles dealing with various aspects of the Palmottu Analogue Project: (1) deep groundwater flow, (2) interpretation of hydraulic connections, (3) characterization of groundwater colloids, (4) uranium mineral-groundwater equilibrium, (5) water-rock interaction and (6) modelling of in situ matrix diffusion. The Palmottu Analogue Project aims at a more profound understanding of radionuclide transport processes in fractured crystalline bedrock. The essential factors controlling transport are groundwater flow and interaction between water and rock. Accordingly, the study includes (1) structural interpretations partly based on geophysical measurements, (2) hydrological studies including hydraulic drill-hole measurements, (3) flow modelling, (4) hydrogeochemical characterization of groundwater, uranium chemistry and colloid chemistry, (5) mineralogical studies, (6) geochemical interpretation and modelling, (7) studies of radionuclide mobilization and retardation including matrix diffusion, and (8) modelling of uranium series data. Palaeohydrogeological aspects, due to the anticipated future glaciation of the Fennoscandian Shield, are of special interest. Quaternary sediments are studied to gain information on post-glacial migration in the overburden. (orig.)

  20. ACTINOMYCIN D ANALOGUES

    DEFF Research Database (Denmark)

    1997-01-01

    acids, $g(b)-amino acids and/or longer chain $g(v)-amino acids, and a difunctional group which preferably is a cyclic entity, in particular, an aromatic or heteroaromatic entity acting as an intercalator group. Specific compounds and a library of such compounds may be prepared using conventional solid......The present invention relates to new compounds being structurally and functionally similar to Actinomycin D and to combinatorial libraries of such compounds. The Actinomycin D analogues according to the present invention comprise two linear or cyclic peptide moieties constituted by $g(a)-amino...

  1. Transaxial analogue tomography

    International Nuclear Information System (INIS)

    Duinker, S.; Geluk, R.J.; Mulder, H.

    1978-01-01

    After an introduction on computerized tomography (CT) scanners summarizing the various generations, the general outline of the concept of a transaxial tomography system is given, which is entirely based on analogue instead of digital techniques (AT system). In particular, the use of X-ray image-intensifier systems as a means of detecting the transmission profiles of the object in a so-called half-field detection method are discussed as well as various possibilities of detector scanning. It is further discussed how in a purely electronic way with the aid of a scan-converter, density profiles representative of parallel beams can be derived from the family of profiles as obtained from the fan-shaped beams in the actual experiment. A practical opto-electronic solution of the analogue spatial filtering problem is described as to how to process, on a real-time basis, parallel density profiles so that after back-projection tomographic images which are free from point-spreading effects will be obtained. Finally, after a brief indication of certain technical details for which corrective measures have to be worked out in the course of practical realization, the main relative advantages of AT scanners in comparison to CT scanners are enumerated. (Auth.)

  2. Alligator Rivers analogue project

    International Nuclear Information System (INIS)

    Duerden, P.

    1990-01-01

    Australian Nuclear Science and Technology Organization has extensively evaluated uranium ore bodies in the Alligator Rivers Uranium Province in Australia as analogues of radioactive waste repositories. The work was extended for a three-year program as an international project based on the Koongarra uranium deposit and sponsored by the OECD Nuclear Energy Agency. The technical program comprises six major sub-projects involving modelling and experimental work: modelling of radionuclide migration; hydrogeology of the Koongarra uranium deposit; uranium/thorium series disequilibria studies; groundwater and colloid studies; fission product studies; transuranic nuclide studies; an outline of the technical programs and a summary of progress in the technical sub-projects is given. This is followed by a series of technical reports which briefly describe current research tasks, and which have been separately indexed

  3. A Short Term Analogue Memory

    DEFF Research Database (Denmark)

    Shah, Peter Jivan

    1992-01-01

    A short term analogue memory is described. It is based on a well-known sample-hold topology in which leakage currents have been minimized partly by circuit design and partly by layout techniques. Measurements on a test chip implemented in a standard 2.4 micron analogue CMOS process show a droop...

  4. Cobalamin analogues in humans

    DEFF Research Database (Denmark)

    Hardlei, Tore Forsingdal; Obeid, Rima; Herrmann, Wolfgang

    2013-01-01

    BACKGROUND: Haptocorrin (HC) carries cobalamin analogues (CorA), but whether CorA are produced in the body is unknown. All cobalamins (Cbl) to the foetus are delivered by the Cbl-specific protein transcobalamin (TC), and therefore analysis of cord serum for CorA may help to clarify the origin...... of CorA. METHODS: HC-CorA were quantified in paired samples of cord serum from newborns and serum from mothers (n = 69). RESULTS: The CorA-concentration was higher in cord serum (median = 380, range: 41-780 pmol/L) than in serum from the mothers (median = 160, range: 64-330 pmol/L), (p...-analysis showed CorA-peaks with retention times of 13.5, 14,5 and 16.5 min in samples from both the mother and cord serum. The peak with retention time 16.5 min constituted 24% (mother) and 45% (cord serum) of the total amount CorA, and eluted as does dicyanocobinamide. CONCLUSION: Our results support that Cor...

  5. Chemoenzymatic preparation of germacrene analogues.

    Science.gov (United States)

    Cascón, Oscar; Touchet, Sabrina; Miller, David J; Gonzalez, Veronica; Faraldos, Juan A; Allemann, Rudolf K

    2012-10-09

    A small library of novel germacrenes was generated using a combination of two plant enzymes, germacrene A synthase, and D synthase and modified farnesyl diphosphate (FDP) analogues. This chemoenzymatic approach allows the preparation of potentially valuable volatiles for biological studies.

  6. Chemoenzymatic preparation of germacrene analogues

    OpenAIRE

    Cascón, Oscar; Touchet, Sabrina; Miller, David James; Gonzalez, Veronica; Faraldos, Juan A.; Allemann, Rudolf Konrad

    2012-01-01

    A small library of novel germacrenes was generated using a combination of two plant enzymes, germacrene A synthase, and D synthase and modified farnesyl diphosphate (FDP) analogues. This chemoenzymatic approach allows the preparation of potentially valuable volatiles for biological studies.

  7. Evaluation des dommages des punaisese( Heteroptera ) et des ...

    African Journals Online (AJOL)

    L'analyse statistique des résultats dans les blocs témoins montre que les punaises occasionnent plus de dommages aux boutons floraux et aux capsules vertes immatures que les chenilles. Sur les jeunes capsules, la moyenne des dommages des punaises et des chenilles reste statistiquement identique. Les traitements ...

  8. Introduction to electronic analogue computers

    CERN Document Server

    Wass, C A A

    1965-01-01

    Introduction to Electronic Analogue Computers, Second Revised Edition is based on the ideas and experience of a group of workers at the Royal Aircraft Establishment, Farnborough, Hants. This edition is almost entirely the work of Mr. K. C. Garner, of the College of Aeronautics, Cranfield. As various advances have been made in the technology involving electronic analogue computers, this book presents discussions on the said progress, including some acquaintance with the capabilities of electronic circuits and equipment. This text also provides a mathematical background including simple differen

  9. Degludec: the new ultra-long insulin analogue.

    Science.gov (United States)

    Tambascia, Marcos Antonio; Eliaschewitz, Freddy Goldberg

    2015-01-01

    The development of extended-action insulin analogues was motivated by the unfavorable pharmacokinetic (PK) profile of the conventional long-acting insulin formulations, generally associated with marked inter and intra patient variability and site- and dose-dependent effect variation. The new ultra-long insulin analogue degludec (IDeg) has the same amino acid sequence as human insulin except for the removal of threonine in the position 30 of the B chain (Des-B30, "De") and the attachment, via a glutamic acid linker ("glu"), of a 16-carbon fatty diacid (hexadecanoic diacid, "dec") to lysine in the position 29 of the B chain. These modifications allow that, after changing from the pharmaceutical formulation to the subcutaneous environment, IDeg precipitates in the subcutaneous tissue, forming a depot that undergoes a highly predictable gradual dissociation. Thus, once-daily dosing of IDeg results in a low peak: trough ratio, with consequent low intra-individual variability and plasmatic concentrations less critically dependent upon the time of injections. The clinical development program of IDeg (BEGIN) was comprised of 9 therapeutic confirmatory trials of longer duration (26-52 weeks) and showed that the efficacy of IDeg is comparable to insulin glargine in type 1 (T1D) and type 2 (T2D) diabetes patients across different age, body mass index and ethnic groups. This new ultra-long insulin analogue presents as advantages flexibility in dose timing and lower risk of hypoglycemia.

  10. Superconductive analogue of spin glasses

    International Nuclear Information System (INIS)

    Feigel'man, M.; Ioffe, L.; Vinokur, V.; Larkin, A.

    1987-07-01

    The properties of granular superconductors in magnetic fields, namely the existence of a new superconductive state analogue of the low-temperature superconductive state in spin glasses are discussed in the frame of the infinite-range model and the finite-range models. Experiments for elucidation of spin-glass superconductive state in real systems are suggested. 30 refs

  11. PTH analogues and osteoporotic fractures

    NARCIS (Netherlands)

    Verhaar, H.J.; Lems, W.F.

    2010-01-01

    Importance of the field: At present there are two parathyroid hormone (PTH) analogues (PTH 1 34 and PTH 1 84) registered for the treatment of established osteoporosis in postmenopausal women (PTH 1 34 and PTH 1 84) and in men (PTH 1 34 only) who are at increased risk of having a fracture. Areas

  12. Chemopreventive properties of curcumin analogues ...

    African Journals Online (AJOL)

    Chemopreventive properties of curcumin analogues, hexagamavunone-0 and gamavutone-0, in rat colorectal cancer model. ... Histopathological analysis was performed using H & E staining and immunohistochemistry with antibodies against adenomatous polyposis coli (APC) and cyclooxygenase 2 (COX-2). Results: All ...

  13. New active analogues of Cucurbita maxima trypsin inhibitor III (CMTI-III) modified in the non-contact region.

    Science.gov (United States)

    Rózycki, J; Kupryszewski, G; Rolka, K; Ragnarsson, U; Zbyryt, T; Krokoszyńska, I; Wilusz, T

    1994-01-01

    Four new analogues of trypsin inhibitor CMTI-III(3-28) = [desArg1,desVal2,desGly29]CMTI-III which was recently shown to be fully active, were synthesized by the solid-phase method. The introduction of glycine in position 9 (peptide 1) and Gly-Pro-Gly (peptide 2) and Gly-Pro-Asn (peptide 3) in the regions 17-19 and 23-25, respectively, did not change the antitrypsin activity of all modified peptides. All of these substitutions are presumed to be outside the trypsin-binding loop as judged from the X-ray structure of the complex between beta-trypsin and the related inhibitor CMTI-I. Also the fourth analogue which was substituted in all the positions mentioned, exhibited the full activity.

  14. Stabilisation de la formule des traces tordue

    CERN Document Server

    Moeglin, Colette

    2016-01-01

    Ce travail en deux volumes donne la preuve de la stabilisation de la formule des trace tordue. Stabiliser la formule des traces tordue est la méthode la plus puissante connue actuellement pour comprendre l'action naturelle du groupe des points adéliques d'un groupe réductif, tordue par un automorphisme, sur les formes automorphes de carré intégrable de ce groupe. Cette compréhension se fait en réduisant le problème, suivant les idées de Langlands, à des groupes plus petits munis d'un certain nombre de données auxiliaires; c'est ce que l'on appelle les données endoscopiques. L'analogue non tordu a été résolu par J. Arthur et dans ce livre on suit la stratégie de celui-ci. Publier ce travail sous forme de livre permet de le rendre le plus complet possible. Les auteurs ont repris la théorie de l'endoscopie tordue développée par R. Kottwitz et D. Shelstad et par J.-P. Labesse. Ils donnent tous les arguments des démonstrations même si nombre d'entre eux se trouvent déjà dans les travaux d'Ar...

  15. Novel acetylcholine and carbamoylcholine analogues

    DEFF Research Database (Denmark)

    Hansen, Camilla Petrycer; Jensen, Anders Asbjørn; Christensen, Jeppe K.

    2008-01-01

    A series of carbamoylcholine and acetylcholine analogues were synthesized and characterized pharmacologically at neuronal nicotinic acetylcholine receptors (nAChRs). Several of the compounds displayed low nanomolar binding affinities to the alpha 4beta 2 nAChR and pronounced selectivity...... for this subtype over alpha 3beta 4, alpha 4beta 4, and alpha 7 nAChRs. The high nAChR activity of carbamoylcholine analogue 5d was found to reside in its R-enantiomer, a characteristic most likely true for all other compounds in the series. Interestingly, the pronounced alpha 4beta 2 selectivities exhibited...... by some of the compounds in the binding assays translated into functional selectivity. Compound 5a was a fairly potent partial alpha 4beta 2 nAChR agonist with negligible activities at the alpha 3beta 4 and alpha 7 subtypes, thus being one of the few truly functionally selective alpha 4beta 2 nACh...

  16. Substrate analogues for isoprenoid enzymes

    Energy Technology Data Exchange (ETDEWEB)

    Stremler, K.E.

    1987-01-01

    Diphosphonate analogues of geranyl diphosphate, resistant to degradation by phosphatases, were found to be alternate substrates for the reaction with farnesyl diphosphate synthetase isolated from avian liver. The difluoromethane analogue was shown to be the better alternate substrate, in agreement with solvolysis results which indicate that the electronegativity of the difluoromethylene unit more closely approximates that of the normal bridging oxygen. The usefulness of the C/sub 10/ difluoro analogue, for detecting low levels of isoprenoid enzymes in the presence of high levels of phosphatase activity, was demonstrated with a cell-free preparation from lemon peel. A series of C/sub 5/ through C/sub 15/ homoallylic and allylic diphosphonates, as well as two 5'-nucleotide diphosphonates, was prepared in high overall yield using the activation-displacement sequence. Radiolabeled samples of several of the allylic diphosphonates were prepared with tritium located at C1. A series of geraniols, stereospecifically deuterated at C1, was prepared. The enantiomeric purities and absolute configurations were determined by derivatization as the mandelate esters for analysis by /sup 1/H NMR. The stereochemistry of the activation-displacement sequence was examined using C1-deuterated substrates.

  17. Ovarian ablation in the adjuvant treatment of breast cancer: GnRH-analogues, ovarectomy or radiocastration - 'The philosopher's stone' instead of 'Chamber of secrets'?; Ovarielle Suppression in der adjuvanten Therapie des Mammakarzinoms: GnRH-Analoga, Ovarektomie oder Radiomenolyse - 'Stein der Weisen' statt 'Kammer des Schreckens'?

    Energy Technology Data Exchange (ETDEWEB)

    Hoffmann, W.; Schiebe, M. [Staedtisches Klinikum Braunschweig (Germany); Seegenschmiedt, H. [Alfried-Krupp-Krankenhaus, Essen (Germany)

    2002-08-01

    Background: Ovarian suppression in the adjuvant treatment of perimenopausal women with breast cancer is an important option. The therapeutic goal can be accomplished by administration of GnRH-analogues, ovarectomy or radiocastration. Patients and methods: We describe the advantages and the therapy related side effects and compare the different treatment modalities with each other. Results: Because of its reversibility and patients' compliance GnRH-analogues seem to be advantageous especially in younger premenopausal women. When longer term side effects of artificially induced menopause are less important, therapeutic alternatives such as radiocastration or ovarectomy are effective without obvious superiority between these options. Conclusion: Even in the background of the increasing use of GnRH-analogues radiocastration remains still a therapeutic alternative because of its cost-effectiveness and feasibility. This accounts especially for peri- or premenopausal women above the age of 45. (orig.) [German] Hintergrund: Bei praemenopausalen Patienten mit rezeptorpositiven Mammakarzinomen stellt die ovarielle Suppression einen wichtigen Schritt in der adjuvanten Therapie dar. Neben den GnRH-Analoga kommen hierfuer die Ovarektomie oder die Radiomenolyse infrage. Patienten und Methode: Die vorliegende Arbeit stellt die Vorteile der einzelnen Therapieoptionen den therapiebedingten Nebenwirkungen gegenueber und vergleicht die Methoden untereinander. Ergebnisse: Wegen der Reversibilitaet und der Patientenakzeptanz sollten GnRH-Analoga besonders bei juengeren praemenopausalen Patientinnen angewendet werden. In der Differentialtherapie von Patientinnen, bei denen die Langzeitnebenwirkungen einer iatrogen induzierten Menopause weniger zu befuerchten sind, kommen auch die anderen Verfahren in Betracht. Hierbei stehen Radiomenolyse und Ovarektomie gleichwertig nebeneinander. Schlussfolgerung: Die differentialtherapeutische Entscheidung zu einer der Methoden sollte

  18. Des Connaissances Aux Politiques

    International Development Research Centre (IDRC) Digital Library (Canada)

    Dans beaucoup de pays en développement, la faible capacité du gouvernement est pratiquement la définition des problèmes de développement du pays. ...... Promouvoir l'échange des connaissances émanant des recherches ainsi que des outils et des résultats, et le dialogue entre les pays, institutions et donateurs.

  19. Variabilite des productions et des revenus des exploitations ...

    African Journals Online (AJOL)

    ... sont à dominance céréale et coton avec environ 75 % des assolements. Les revenus nets des EAF montrent en moyenne une prédominance des productions végétales (1 394 976 Fcfa) et animales, (1 420 430 Fcfa) sur les activités de diversification (358 449 Fcfa). Mots clés : production, revenu, économie, performance, ...

  20. Modelisation des effets physico-techniques pour la conception des ...

    African Journals Online (AJOL)

    automatisation dans les installations industrielles a besoin d'une régulation automatique des commandes des processus technologiques pour lesquelles certaines contraintes sont à relever compte tenu des exigences des innovations scientifiques de ...

  1. The Valles natural analogue project

    International Nuclear Information System (INIS)

    Stockman, H.; Krumhansl, J.; Ho, C.; McConnell, V.

    1994-12-01

    The contact between an obsidian flow and a steep-walled tuff canyon was examined as an analogue for a highlevel waste repository. The analogue site is located in the Valles Caldera in New Mexico, where a massive obsidian flow filled a paleocanyon in the Battleship Rock tuff. The obsidian flow provided a heat source, analogous to waste panels or an igneous intrusion in a repository, and caused evaporation and migration of water. The tuff and obsidian samples were analyzed for major and trace elements and mineralogy by INAA, XRF, X-ray diffraction; and scanning electron microscopy and electron microprobe. Samples were also analyzed for D/H and 39 Ar/ 4O isotopic composition. Overall,the effects of the heating event seem to have been slight and limited to the tuff nearest the contact. There is some evidence of devitrification and migration of volatiles in the tuff within 10 meters of the contact, but variations in major and trace element chemistry are small and difficult to distinguish from the natural (pre-heating) variability of the rocks

  2. variabilite des productions et des revenus des exploitations

    African Journals Online (AJOL)

    3Centre de coopération internationale en recherche agronomique pour le développement (CIRAD), UMR Innovation,. Montpellier, France. Doubangolo COULIBALY, Email kone_b@yahoo.fr. RESUME. La durabilité des systèmes de production à base de coton dans un contexte de variabilité des prix aux producteurs et de ...

  3. La metamorphose des cypris femelles des Rhizocephales

    NARCIS (Netherlands)

    Veillet, A.

    1964-01-01

    Depuis la découverte de la métamorphose des cypris de Sacculina carcini Thompson par Delage, peu de biologistes se sont intéressés au développement des Rhizocéphales. On admet aujourd'hui que tous les Cirripèdes parasites ont, comme Sacculina carcini, une forme kentrogone qui inocule le parasite au

  4. Direction des Publications

    African Journals Online (AJOL)

    Synthese

    37. Taux des lipides et des protéines et composition en acides gras du tissu comestible des crustacés et des mollusques pêchés en Algérie : Effet du halofénozide (RH-0345) sur la composition en acides gras de. Penaeus kerathurus (Crustacé, Décapode). Samira Gheid. 1. , Safia Nadji. 2 et Mohamed El Hadi Khebbeb. 3.

  5. Methoden Des Fremdsprachenunterrichts

    Directory of Open Access Journals (Sweden)

    Rasa Sklizmantaitė

    2011-04-01

    Full Text Available Beim Unterrichten einer Fremdsprache ist es wichtig, Methoden des Fremdsprachenunterrichts zu kennen, um eine Methode des Unterrichts nach dem Niveau und Bedürfnissen der entsprechenden Gruppe opti-mal zu wählen. Im Artikel wird der Überblick des Fremdsprachenunterrichts im Hinblick auf historische Entwicklung dargeboten sowie die Hauptmerkmale einiger Methoden des Fremdsprachenunterrichts aufgezählt.

  6. Des racines et des ailes

    Directory of Open Access Journals (Sweden)

    Stéphanie Vincent-Geslin

    2012-05-01

    Full Text Available Les mobilités pendulaires semblent être en augmentation en Europe depuis une dizaine d’années. Cette croissance du temps passé à se déplacer amène à remettre en question la conjecture de Zahavi et apparaît relativement inexplicable en regard du paradigme classique de l’acteur rationnel traditionnellement utilisé dans le champ des transports. Si, dans la littérature, les temps de déplacements sont principalement expliqués par le contexte résidentiel, la forme urbaine et le travail, ce cadre explicatif ne dit rien des processus de décision eux-mêmes qui amènent aux pendularités intensives.À partir d’une enquête qualitative menée auprès de pendulaires français, suisses et belges, cette contribution propose d’analyser les arbitrages et les éléments déterminants des processus de la grande pendularité. Les mobilités quotidiennes pendulaires apparaissent comme le résultat de compromis entre activité professionnelle, attachement résidentiel et choix de vie et prennent ainsi la forme de stratégies de conciliation entre vie privée et vie professionnelle. Ces mobilités spatiales permettent alors paradoxalement la préservation des ancrages résidentiels, sociaux et familiaux.Roots and wings. Long-distance commuting patterns, or how to conciliate professional and personal lifeLong-distance commuting patterns appear to be increasing in Europe over the last ten years. These raising mobility patterns lead to reappraise the Zahavi conjecture and appear largely inexplicable by the classical rational actor paradigm traditionally used in transportation research. In literature, commuting is mainly explained by residential contexts, urban forms and job. Nevertheless this theoretical frame says little about the decision-making processes themselves. Based on a qualitative survey conducted in three European countries - France, Belgium and Switzerland – among a population of high commuters, this paper proposes an analysis of

  7. Civili, langue des Baloango

    DEFF Research Database (Denmark)

    Mavoungou, Paul Achille; Ndinga-Koumba-Binza, Hugues Steve

    , Congo, Angola, etc.) issus de la décolonisation. Il présente de façon succincte quelques phénomènes historiques, phonologiques, morphosyntaxiques, homonymiques et analogiques de la langue. Des faits sémantiques des emprunts linguistiques y sont également décrits dans le cadre des changements...

  8. ANALYSE DES PERCEPTIONS LOCALES ET DES FACTEURS ...

    African Journals Online (AJOL)

    AISA

    haies vives) et la valorisation des produits forestiers tels que l'utilisation des tourteaux comme engrais organiques (Francis et al.,. 2005). Plusieurs études ont montré que les perceptions paysannes d'une technologie ou d'une innovation sont déterminantes pour son adoption. (Adesina et Baidu-forson, 1996). Les travaux.

  9. Littoral Infrared Ship Self Defence Technology Studies (Autodefense cotiere infrarouge des navires etudes technologiques)

    Science.gov (United States)

    2014-05-01

    le SET-088 a organisé un total de cinq ateliers scientifiques, où des experts en la matière de tous les pays membres (aussi bien de l’OTAN que des...doivent comporter la dénomination « STO », « RTO » ou « AGARD » selon le cas, suivi du numéro de série. Des informations analogues, telles que le titre...Bakanlığı (MSB) Defense Technical Information Center PORTUGAL ARGE ve Teknoloji Dairesi 8725 John J. Kingman Road Estado Maior da Força Aérea

  10. Condensed matter analogues of cosmology

    Science.gov (United States)

    Kibble, Tom; Srivastava, Ajit

    2013-10-01

    It is always exciting when developments in one branch of physics turn out to have relevance in a quite different branch. It would be hard to find two branches farther apart in terms of energy scales than early-universe cosmology and low-temperature condensed matter physics. Nevertheless ideas about the formation of topological defects during rapid phase transitions that originated in the context of the very early universe have proved remarkably fruitful when applied to a variety of condensed matter systems. The mathematical frameworks for describing these systems can be very similar. This interconnection has led to a deeper understanding of the phenomena in condensed matter systems utilizing ideas from cosmology. At the same time, one can view these condensed matter analogues as providing, at least in a limited sense, experimental access to the phenomena of the early universe for which no direct probe is possible. As this special issue well illustrates, this remains a dynamic and exciting field. The basic idea is that when a system goes through a rapid symmetry-breaking phase transition from a symmetric phase into one with spontaneously broken symmetry, the order parameter may make different choices in different regions, creating domains that when they meet can trap defects. The scale of those domains, and hence the density of defects, is constrained by the rate at which the system goes through the transition and the speed with which order parameter information propagates. This is what has come to be known as the Kibble-Zurek mechanism. The resultant scaling laws have now been tested in a considerable variety of different systems. The earliest experiments illustrating the analogy between cosmology and condensed matter were in liquid crystals, in particular on the isotropic-to-nematic transition, primarily because it is very easy to induce the phase transition (typically at room temperature) and to image precisely what is going on. This field remains one of the

  11. Antimicrobial Activity of Resveratrol Analogues

    Directory of Open Access Journals (Sweden)

    Malik Chalal

    2014-06-01

    Full Text Available Stilbenes, especially resveratrol and its derivatives, have become famous for their positive effects on a wide range of medical disorders, as indicated by a huge number of published studies. A less investigated area of research is their antimicrobial properties. A series of 13 trans-resveratrol analogues was synthesized via Wittig or Heck reactions, and their antimicrobial activity assessed on two different grapevine pathogens responsible for severe diseases in the vineyard. The entire series, together with resveratrol, was first evaluated on the zoospore mobility and sporulation level of Plasmopara viticola (the oomycete responsible for downy mildew. Stilbenes displayed a spectrum of activity ranging from low to high. Six of them, including the most active ones, were subsequently tested on the development of Botrytis cinerea (fungus responsible for grey mold. The results obtained allowed us to identify the most active stilbenes against both grapevine pathogens, to compare the antimicrobial activity of the evaluated series of stilbenes, and to discuss the relationship between their chemical structure (number and position of methoxy and hydroxy groups and antimicrobial activity.

  12. Appropriation des Tic et performance des entreprises

    OpenAIRE

    Lethiais , Virginie; Smati , Wided

    2009-01-01

    Quatre pages Marsouin; L'utilisation des TIC (Technologies de l'information et de la Communication) se développe dans les entreprises pour assurer des tâches de plus en plus nombreuses : la communication, la recherche d'informations, la commercialisation des produits et services, le travail en groupe, la gestion de l'entreprise, la prospection, etc. Les équipements en TIC ainsi que l'usage qui en est fait diffèrent d'une entreprise à une autre selon de nombreux critères. L'objet de ce quatre ...

  13. An arsenical analogue of adenosine diphosphate.

    Science.gov (United States)

    Webster, D; Sparkes, M J; Dixon, H B

    1978-01-01

    An analogue of ADP was made in which the terminal phosphono-oxy group, -O-PO(OH)2, has been replaced by the arsonomethyl group, -CH2-AsO(OH)2. This compound cannot form a stable analogue of ATP because anhydrides of arsonic acids are rapidly hydrolysed, so that any enzyme that phosphorylates ADP and accepts this analogue as a substrate should release orthophosphate in its presence. The analogue proves to be a poor substrate for 3-phosphoglycerate kinase (V/Km is diminished by a factor of 10(2)-10(3)) and a very poor substrate for pyruvate kinase (V/Km is diminished by a factor of 10(5)-10(6)). No substrate action was detected with adenyl kinase and creatine kinase. PMID:204292

  14. International video project on natural analogues

    International Nuclear Information System (INIS)

    Guentensperger, Marcel

    1993-01-01

    A natural analogue can be defined as a natural process which has occurred in the past and is studied in order to test predictions about the future evolution of similar processes. In recent years, natural analogues have been used increasingly to test the mathematical models required for repository performance assessment. Analogues are, however, also of considerable use in public relations as they allow many of the principles involved in demonstrating repository safety to be illustrated in a clear manner using natural systems with which man is familiar. The international Natural Analogue Working Group (NAWG), organised under the auspices of the CEC, has recognised that such PR applications are of considerable importance and should be supported from a technical level. At the NAWG meeting in Pitlochry, Scotland (June 1990), it was recommended that the possibilities for making a video film on this topic be investigated and Nagra was requested to take the lead role in setting up such a project

  15. Natural analogues and radionuclide transport model validation

    International Nuclear Information System (INIS)

    Lever, D.A.

    1987-08-01

    In this paper, some possible roles for natural analogues are discussed from the point of view of those involved with the development of mathematical models for radionuclide transport and with the use of these models in repository safety assessments. The characteristic features of a safety assessment are outlined in order to address the questions of where natural analogues can be used to improve our understanding of the processes involved and where they can assist in validating the models that are used. Natural analogues have the potential to provide useful information about some critical processes, especially long-term chemical processes and migration rates. There is likely to be considerable uncertainty and ambiguity associated with the interpretation of natural analogues, and thus it is their general features which should be emphasized, and models with appropriate levels of sophistication should be used. Experience gained in modelling the Koongarra uranium deposit in northern Australia is drawn upon. (author)

  16. Cartographie des directions dominantes des vents au Benin : Outil ...

    African Journals Online (AJOL)

    Cartographie des directions dominantes des vents au Benin : Outil de conception et de dimensionnement des ouvrages. ... nous avons, après la collecte des informations météorologiques, procédé : - à l'analyse des données (directions) des six stations météorologiques principales conformément aux méthodes statistiques.

  17. Applications biotechnologiques des mycorhizes

    OpenAIRE

    Redecker, Dirk

    2012-01-01

    La symbiose mycorhizienne est une association entre un champignon mycorhizogène et une racine de plante-hôte. La mycorrhize à arbuscules (MA) est extrêmement ancienne puisqu’elle est datée de la même époque que l’apparition des plantes terrestres, il y a 460 millions d’années. Elle s’effectue entre un champignon mycorhizogène à arbuscules (CMA, phylum Glomeromycota) et plus de 80% des plantes terrestres. Les CMA sont des microorganismes ubiquitaires du sol et sont des biotrophes obligatoires ...

  18. Between Analogue and Digital Diagrams

    Directory of Open Access Journals (Sweden)

    Zoltan Bun

    2012-10-01

    Full Text Available This essay is about the interstitial. About how the diagram, as a method of design, has lead fromthe analogue deconstruction of the eighties to the digital processes of the turn of the millennium.Specifically, the main topic of the text is the interpretation and the critique of folding (as a diagramin the beginning of the nineties. It is necessary then to unfold its relationship with immediatelypreceding and following architectural trends, that is to say we have to look both backwards andforwards by about a decade. The question is the context of folding, the exchange of the analogueworld for the digital. To understand the process it is easier to investigate from the fields of artand culture, rather than from the intentionally perplicated1 thoughts of Gilles Deleuze. Both fieldsare relevant here because they can similarly be used as the yardstick against which the era itselfit measured. The cultural scene of the eighties and nineties, including performing arts, movies,literature and philosophy, is a wide milieu of architecture. Architecture responds parallel to itsera; it reacts to it, and changes with it and within it. Architecture is a medium, it has always beena medium, yet the relations are transformed. That’s not to say that technical progress, for exampleusing CAD-software and CNC-s, has led to the digital thinking of certain movements ofarchitecture, (it is at most an indirect tool. But the ‘up-to-dateness’ of the discipline, however,a kind of non-servile reading of an ‘applied culture’ or ‘used philosophy’2 could be the key.(We might recall here, parenthetically, the fortunes of the artistic in contemporary mass society.The proliferation of museums, the magnification of the figure of the artist, the existence of amassive consumption of printed and televised artistic images, the widespread appetite for informationabout the arts, all reflect, of course, an increasingly leisured society, but also relateprecisely to the fact

  19. Gestion des risques

    CERN Document Server

    Louisot, Jean-Paul

    2009-01-01

    Depuis le début du lie siècle, la gestion des risques connaît une véritable révolution culturelle. Jusqu'alors fonction technique, centrée autour de l'achat de couverture d'assurances, elle est devenue une discipline managériale et transversale : une valise d'instruments que chaque manager doit connaître et appliquer quels que soient son domaine de compétence et ses missions au sein de l'organisation. En effet, la gestion des risques est une culture qui doit être assimilée par chacun des acteurs. C'est précisément l'ambition des 101 questions rassemblées dans cet ouvrage : apporter à chaque manager d'entreprise, de collectivité, d'établissement de santé..., des réponses claires au " pourquoi " et au " comment " : Comment identifier les risques ? Comment analyser les risques ? Quels sont les objectifs de la gestion des risques ? Une carte des risques pour quoi faire ? Pourquoi faut-il financer les risques ? Les entreprises ont-elles des responsabilités pénales ? En quoi consiste la gestion...

  20. La gouvernance des risques naturels et la problematique des ...

    African Journals Online (AJOL)

    Depuis quelques années, la gouvernance des risques naturels dus aux inondations remet en cause les processus de mise en oeuvre des politiques urbaines et la qualité de la structure des aménagements dans les grandes villes du Golfe de Guinée. La perception de la gouvernance et l'application des politiques de ...

  1. Synthesis and anticancer evaluation of spermatinamine analogues

    KAUST Repository

    Moosa, Basem

    2016-02-04

    Spermatinamine was isolated from an Australian marine sponge, Pseudoceratina sp. as an inhibitor of isoprenylcystiene carboxyl methyltransferase (Icmt), an attractive and novel anticancer target. Herein, we report the synthesis of spermatinamine analogues and their cytotoxic evaluation against three human cancer cell lines i.e. cervix adenocarcinoma (HeLa), breast adenocarcinoma (MCF-7), and prostate carcinoma (DU145). Analogues 12, 14 and 15 were found to be the most potent against one or more cell lines with the IC50 values in the range of 5 - 10 μM. The obtained results suggested that longer polyamine linker along with aromatic oxime substitution provided the most potent analogue compounds against cancer cell lines.

  2. Analogue alternative the electronic analogue computer in Britain and the USA, 1930-1975

    CERN Document Server

    Small, James S

    2013-01-01

    We are in the midst of a digital revolution - until recently, the majority of appliances used in everyday life have been developed with analogue technology. Now, either at home or out and about, we are surrounded by digital technology such as digital 'film', audio systems, computers and telephones. From the late 1940s until the 1970s, analogue technology was a genuine alternative to digital, and the two competing technologies ran parallel with each other. During this period, a community of engineers, scientists, academics and businessmen continued to develop and promote the analogue computer.

  3. Photonique des Morphos

    CERN Document Server

    Berthier, Serge

    2010-01-01

    La photonique est déjà présente dans notre vie quotidienne, et on attend maintenant que la manipulation des photons permette aussi le traitement logique des informations. Cependant, l’élément de base qui permet cette manipulation de la lumière, le cristal photonique, est d’une réalisation complexe et mal contrôlée. Dans la course à la maîtrise de la lumière, les structures photoniques naturelles ont beaucoup à nous apprendre. C’est ce que nous montre Serge Berthier qui étudie dans ce livre la structure des écailles des Morphos. Tenant compte de l’essor récent des approches biomimétiques, il présente de manière détaillée plus de dix-huit techniques expérimentales utilisées pour ses analyses, ainsi que les diverses approches théoriques développées pour la modélisation de structures multi-échelles complexes. Première étude quasi-exhaustive des structures fines d’un genre et des propriétés optiques ainsi que colorimétriques générées, ce livre fournit aux entomologiste...

  4. Droit des organisations internationales

    CERN Document Server

    Sorel, Jean-Marc; Ndior, Valère

    2013-01-01

    Cet ouvrage collectif offre aux enseignants et chercheurs en droit international, aux praticiens et aux étudiants, une analyse actualisée du droit des organisations internationales. Il dresse en cinq parties un tableau, illustré par des exemples variés, des problématiques que soulève le phénomène polymorphe d institutionnalisation de la société internationale. La première partie est consacrée au phénomène des « organisations internationales », sous l angle à la fois de l institutionnalisation progressive des relations internationales et de la difficulté à cerner une catégorie unifiée. La deuxième partie rend compte de la création, de la disparition et des mutations des organisations internationales, ici envisagées comme systèmes institutionnels et ordres juridiques dérivés. La troisième partie analyse l autonomie que l acquisition de la personnalité juridique et de privilèges et immunités, un organe administratif intégré, un personnel ou un budget propres confèrent aux organi...

  5. Terminologie des indices boursiers

    OpenAIRE

    Van der Yeught, Michel

    2013-01-01

    Les indices boursiers sont omniprésents en anglais financier. Les plus importants sont universellement familiers mais leur nature et leur fonctionnement restent largement méconnus. Des distinctions (average/index, narrow index/broad index, price-weighted/market value-weighted, all share/ composite/ subindex) permettront à l’angliciste de spécialité d’adapter à chaque indice la terminologie française ou anglaise qui lui correspond. Des remarques sur des erreurs courantes, un mini-glossaire, un...

  6. Total synthesis of sannanine and analogues thereof

    Indian Academy of Sciences (India)

    BADHER NAVEEN

    2018-03-02

    Mar 2, 2018 ... concise manner. The key strategies involve Friedländer quinoline synthesis, demethylation, in situ oxidation and amination process. ..... (b) Hargreaves R, David C L, Whitesell L and Skibo E. B 2003 Design of Quinolinedione-Based Geldanamycin. Analogues Bioorg. Med. Chem. Lett. 13 3075; (c) Arg-.

  7. Ultrasound exfoliation of inorganic analogues of graphene

    Czech Academy of Sciences Publication Activity Database

    Štengl, Václav; Henych, Jiří; Slušná, Michaela; Ecorchard, Petra

    2014-01-01

    Roč. 9, APR (2014), s. 1-14 ISSN 1556-276X R&D Projects: GA ČR(CZ) GA14-05146S Institutional support: RVO:61388980 Keywords : Ultrasound * Exfoliation * Graphene inorganic analogues Subject RIV: CA - Inorganic Chemistry Impact factor: 2.779, year: 2014

  8. The World Is either Digital or Analogue

    NARCIS (Netherlands)

    Berto, F.; Tagliabue, J.

    2014-01-01

    We address an argument by Floridi (Synthese 168(1):151-178, 2009; 2011a), to the effect that digital and analogue are not features of reality, only of modes of presentation of reality. One can therefore have an informational ontology, like Floridi’s Informational Structural Realism, without

  9. Somatostatin analogue scintigraphy and tuberculosis: case report

    International Nuclear Information System (INIS)

    Biancheri, I.; Rudenko, B.; Vautrin, P.; Raddoul, J.; Lamfichek, N.; Kantelip, B.; Mantion, G.

    2005-01-01

    Scintigraphy using a radiolabelled somatostatin analogue (111 In-pentetreotide) is useful in the detection of neuroendocrine tumors. But this radiopharmaceutical accumulates also in solid tumours or in inflammatory diseases such as granulomatosis. We present a case of 111 In-pentetreotide uptake in a tuberculous adenopathy. (author)

  10. Prussian Blue Analogues of Reduced Dimensionality

    NARCIS (Netherlands)

    Gengler, Regis Y. N.; Toma, Luminita M.; Pardo, Emilio; Lloret, Francesc; Ke, Xiaoxing; Van Tendeloo, Gustaaf; Gournis, Dimitrios; Rudolf, Petra

    2012-01-01

    Mixed-valence polycyanides (Prussian Blue analogues) possess a rich palette of properties spanning from room-temperature ferromagnetism to zero thermal expansion, which can be tuned by chemical modifications or the application of external stimuli (temperature, pressure, light irradiation). While

  11. The Palmottu analogue project: overview for 1993

    International Nuclear Information System (INIS)

    Ruskeeniemi, T.; Blomqvist, R.; Suksi, J.; Niini, H.

    1994-01-01

    This article gives a summary of the activities carried out within the Palmottu analogue project in 1993. It consists of (1) an introductory part, followed by (2) a geological description of the site, and (3)an up-to-date summary of the results of the project. (orig.) (33 refs., 6 figs.)

  12. Natural product analogues: towards a blueprint for analogue-focused synthesis.

    Science.gov (United States)

    Bebbington, Magnus W P

    2017-08-14

    For the first time a general overview of approaches to the synthesis of natural product analogues is presented. This reflects a process of evolution of natural product synthesis which has accelerated in the years since the implementation of diversity-oriented synthesis, which has emerged in parallel with collective synthesis, diverted total synthesis and the preparation of truncated natural products optimised for biological activity. A method involving computational assessment for the validation of core-modified natural product analogues is discussed.

  13. Dental Encounter System (DES)

    Data.gov (United States)

    Department of Veterans Affairs — Dental Encounter System (DES) is an automated health care application designed to capture critical data about the operations of VA Dental Services. Information on...

  14. Die Wahrheit des Holocaust

    Directory of Open Access Journals (Sweden)

    Michael Stolleis

    2003-01-01

    Full Text Available Rezensiertes Werk: Raul Hilberg, Die Quellen des Holocaust. Entschlüsseln und Interpretieren. Deutsch von Udo Rennert, Frankfurt am Main: S. Fischer 2002, 256 S., ISBN 3-10-033626-7

  15. Direction des Publications

    African Journals Online (AJOL)

    Synthese

    Key words: cathode sputtering magnetron; thin films; nanostructure; corrosion; alloys Fe-Si. 1. INTRODUCTION. Les alliages de fer–Silicium (FexSiy) sont des matériaux importants, largement répandus dans des circuits électroniques et magnétiques, et jouissent d‟un excellent rapport qualité/prix. Ce succès est lie aux.

  16. typologie des parcs agroforestiers

    African Journals Online (AJOL)

    AISA

    AU SENEGAL : TYPOLOGIE DES PARCS AGROFORESTIERS. I. COLY1, L. E. AKPO1, D. SARR1, R. MALOU2, H. DACOSTA3 et F. DIOME4. 1Faculté des Sciences et ... Mots clés : Agro-écologie, parcs agro forestiers, typologie, Bas fonds de la Néma, Sénégal. .... afin d'en distinguer les sous unités, et d'en établir.

  17. Direction des Publications

    African Journals Online (AJOL)

    Synthese

    1 mai 2011 ... microscopie électronique à balayage (MEB) et la diffraction des rayons X (DRX). Nous avons effectué des essais d‟oxydation à haute température sur trois alliages binaires FeAl à 1 000 oC, dans une atmosphère d'air de laboratoire et à pression atmosphérique. Les essais d‟oxydation menés à 1000 °C ...

  18. Direction des Publications

    African Journals Online (AJOL)

    Synthese

    déclin avec le développement de la chimie de synthèse, toutefois les effets indésirables des médicaments ont ravivé l‟intérêt des scientifiques pour les plantes médicinales. C‟est ainsi que de nouvelles recherches ont vu le jour, notamment de l‟espoir de traiter certaines maladies infectieuses par les huiles essentielles.

  19. Direction des Publications

    African Journals Online (AJOL)

    Synthese

    profondes aux fosses abyssales représentant ainsi un important réservoir de biodiversité. .... des animaux menacés de l‟IUCN (Union. Internationale pour la Conservation de la. Nature) comporte plus de 100 ..... lacunes de notre compréhension des capacités de réponses et d‟adaptation de la biodiversité. Jackson et al.

  20. Tryptophan analogues. 1. Synthesis and antihypertensive activity of positional isomers.

    Science.gov (United States)

    Safdy, M E; Kurchacova, E; Schut, R N; Vidrio, H; Hong, E

    1982-06-01

    A series of tryptophan analogues having the carboxyl function at the beta-position was synthesized and tested for antihypertensive activity. The 5-methoxy analogue 46 exhibited antihypertensive activity in the rat via the oral route and was much more potent than the normal tryptophan analogue. The methyl ester was found to be a critical structural feature for activity.

  1. La revolution des savants

    CERN Document Server

    Chavanne, A

    1989-01-01

    Premiere cassette : - 1666 : impact de la creation de l'Academie des Sciences par Colbert, trente ans apres le proces de Galile, et au moment des disparitions de Pascal, Descartes et Fermat. Elle dirigee par le hollandais Huyggens jusqu'a sa fuite de France au moment de la revocation de l'Edit de Nantes. - 1750 : l'Encyclopedie (ou "Dictionnaire raisonne des Sciences, des Arts et des Metiers") de Diderot et d'Alembert, soutenus par Malherbes, Buffon, Condorcet et Rousseau. - 1789 : Revolution francaise. - 8 aout 1793 : l'Assemblee, par une declaration de Marat, dissout l'Academie des Sciences. Celle-ci continue cependant ses travaux pour les poids et mesures jusqu'en 1795. - la Terreur : la condamnation a mort, pas au nom d'une "Revolution qui n'a pas besoin de savants" mais pour d'autres raisons, de trois grands hommes de science : Lavoisier, Bailly et Condorcet. - 1793-1794 : Au printemps 93, le Comite de Salut Publique s'inquiete du demi-million de soldats etrangers de toutes les pays frontaliers qui essai...

  2. Somatostatin analogues for acute bleeding oesophageal varices

    DEFF Research Database (Denmark)

    Gøtzsche, Peter C.; Hrobjartsson, A.

    2008-01-01

    BACKGROUND: Somatostatin and its derivatives are sometimes used for emergency treatment of bleeding oesophageal varices in patients with cirrhosis of the liver. OBJECTIVES: To study whether somatostatin or its analogues improve survival or reduce the need for blood transfusions in patients...... with bleeding oesophageal varices. SEARCH STRATEGY: PubMed and The Cochrane Library were searched (November 2007). Reference lists of publications, contacts with authors. SELECTION CRITERIA: All randomised trials comparing somatostatin or analogues with placebo or no treatment in patients suspected of acute...... or recent bleeding from oesophageal varices. DATA COLLECTION AND ANALYSIS: The outcome measures extracted were: mortality, blood transfusions, use of balloon tamponade, initial haemostasis and rebleeding. Intention-to-treat analyses including all randomised patients were conducted if possible; a random...

  3. Studies of natural analogues and geological systems

    International Nuclear Information System (INIS)

    Brandberg, F.; Grundfelt, B.; Hoeglund, L.; Skagius K.; Karlsson, F.; Smellie, J.

    1993-04-01

    This review has involved studies of natural analogues and natural geological systems leading to the identification and quantification of processes and features of importance to the performance and safety of repositories for radioactive waste. The features and processes selected for the study comprise general geochemical issues related to the performance of the near- and far-field, the performance and durability of construction materials and the effects of glaciation. For each of these areas a number of potentially important processes for repository performance have been described, and evidence for their existence, as well as quantification of parameters of models describing the processes have been sought from major natural analogue studies and site investigations. The review has aimed at covering a relatively broad range of issues at the expense of in-depth analysis. The quantitative data presented are in most cases compilations of data from the literature; in a few cases results of evaluations made within the current project are included

  4. Boron hydride analogues of the fullerenes

    International Nuclear Information System (INIS)

    Quong, A.A.; Pederson, M.R.; Broughton, J.Q.

    1994-01-01

    The BH moiety is isoelectronic with C. We have studied the stability of the (BH) 60 analogue of the C 60 fullerene as well as the dual-structure (BH) 32 icosahedron, both of them being putative structures, by performing local-density-functional electronic calculations. To aid in our analysis, we have also studied other homologues of these systems. We find that the latter, i.e., the dual structure, is the more stable although the former is as stable as one of the latter's lower homologues. Boron hydrides, it seems, naturally form the dual structures used in algorithmic optimization of complex fullerene systems. Fully relaxed geometries are reported as well as electron affinities and effective Hubbard U parameters. These systems form very stable anions and we conclude that a search for BH analogues of the C 60 alkali-metal supeconductors might prove very fruitful

  5. Etude des comportements rheologiques des melanges de farine ble ...

    African Journals Online (AJOL)

    Etude des comportements rheologiques des melanges de farine ble/sorgho sans tanins issue de trois nouvelles varietes cultivees au Senegal et mise au point de pains a base de farines composees (ble/sorgho)

  6. Effets des biomasses vertes de Tithonia diversifolia et des engrais ...

    African Journals Online (AJOL)

    Effets des biomasses vertes de Tithonia diversifolia et des engrais minéraux sur la croissance, le développement et le rendement du manioc ( Manihot esculenta Crantz) en zone forestière du Cameroun.

  7. À propos des occasionnalismes

    Directory of Open Access Journals (Sweden)

    Dal Georgette

    2016-01-01

    Full Text Available Les occasionnalismes (nonce formations ou contextual formations dans la terminologie anglo-saxonne, qu’on définira provisoirement comme de “new complex word[s] created by a speaker/writer on the spur of the moment to cover some immediate need” (Bauer, 1983 : 45 ont, à notre connaissance, peu retenu l’attention des morphologues du domaine francophone. Pourtant, toutes les conditions sont désormais réunies pour que cet objet, invisible lorsqu’il s’agissait de décrire le système morphologique du français (ou d’autres langues à partir de ressources dictionnairiques, émerge en tant qu’observable dans une morphologie puisant ses données dans le réel langagier des locuteurs. Par définition en effet, on s’attend à ce qu’un occasionalisme soit absent des dictionnaires (nous verrons que, dans les faits, la situation est plus complexe que cela, et que ces contextual formations ne puissent pas être étudiées en dehors du contexte dans lequel elles ont été produites. À cet égard, la Toile et les produits qui en dérivent constituent des ressources de choix. C’est particulièrement vrai des forums, dans lesquels les internautes s’expriment librement, laissant libre cours à leur potentiel créatif (ou ce qu’ils pensent tel. Dans la présente communication, après avoir défini la notion d’occasionalisme, nous utiliserons un corpus constitué au fil d’autres recherches pour dégager des motifs récurrents propices à leur apparition, autrement dit pour établir une grammaire des occasionnalismes.

  8. The synthesis and pharmacology of ephedrine analogues

    OpenAIRE

    Mullen, Aidan J

    1991-01-01

    In this report we set out to extend recent studies on substituted PAC analogues produced by the fermentation of aromatic aldehydes with Saccharomyces cerevisiae. The medium selected contained glucose as a carbon source for the biotransformation, and sodium pyruvate as an inhibitor for alcohol dehydrogenase, the enzyme responsible for the conversion of the carbinol to a benzyl alcohol derivatives. An investigation of sodium cyanoborohydride for a selective reductive ami...

  9. Electromagnetic wave analogue of electronic diode

    OpenAIRE

    Shadrivov, Ilya V.; Powell, David A.; Kivshar, Yuri S.; Fedotov, Vassili A.; Zheludev, Nikolay I.

    2010-01-01

    An electronic diode is a nonlinear semiconductor circuit component that allows conduction of electrical current in one direction only. A component with similar functionality for electromagnetic waves, an electromagnetic isolator, is based on the Faraday effect of the polarization state rotation and is also a key component of optical and microwave systems. Here we demonstrate a chiral electromagnetic diode, which is a direct analogue of an electronic diode: its functionality is underpinned by ...

  10. Geometric Analogue of Holographic Reduced Representation

    OpenAIRE

    Aerts, Diederik; Czachor, Marek; De Moor, Bart

    2007-01-01

    Holographic reduced representations (HRR) are based on superpositions of convolution-bound $n$-tuples, but the $n$-tuples cannot be regarded as vectors since the formalism is basis dependent. This is why HRR cannot be associated with geometric structures. Replacing convolutions by geometric products one arrives at reduced representations analogous to HRR but interpretable in terms of geometry. Variable bindings occurring in both HRR and its geometric analogue mathematically correspond to two ...

  11. Analogue forecasting of New Zealand climate anomalies

    Science.gov (United States)

    Mullan, A. Brett; Thompson, Craig S.

    2006-03-01

    An analogue forecast scheme is described for multifield prediction of monthly and seasonal New Zealand climate anomalies on the basis of the methodology of Livezey and Barnston ([1988]) for US seasonal temperatures. The method is applied to predicting terciles of temperature and precipitation for six regions of New Zealand. Empirical orthogonal function analysis is used to reduce sea surface temperature and sea-level pressure predictors down to a set of five independent indices, which incorporate variations due to El Niño-Southern Oscillation, Indian Ocean sea temperatures and a wave 3 pattern in the Southern Hemisphere westerlies. A full bootstrap cross-validation procedure is carried out, along with Monte Carlo tests, to assess the skill of the method on independent data and to determine the significance of the results. Significant skill is found for seasonal temperature forecasts for the summer and winter seasons; there is less success in predicting monthly temperatures or rainfall at either timescale. Considerable care is required to constrain the climate state vector, from which analogues are defined, and to constrain the search procedure itself, in order to produce results that are stable with respect to small parameter changes in the model. For the New Zealand region, 5 to 7 is found to be the optimum number of closest analogues, and the inclusion of anti-analogues improves the predictions, at least in the seasonal case. Skill in predicting regional temperature and rainfall is shown to be related to a combination of skill in predicting sea-level pressure patterns and to how strongly these patterns project onto temperature and rainfall anomalies.

  12. The Brookhaven electron analogue, 1953--1957

    International Nuclear Information System (INIS)

    Plotkin, M.

    1991-01-01

    The following topics are discussed on the Brookhaven electron analogue: L.J. Haworth and E.L. VanHorn letters; Original G.K. Green outline for report; General description; Parameter list; Mechanical Assembly; Alignment; Degaussing; Vacuum System; Injection System; The pulsed inflector; RF System; Ferrite Cavity; Pick-up electrodes and preamplifiers; Radio Frequency power amplifier; Lens supply; Controls and Power; and RF acceleration summary

  13. The Brookhaven electron analogue, 1953--1957

    Energy Technology Data Exchange (ETDEWEB)

    Plotkin, M.

    1991-12-18

    The following topics are discussed on the Brookhaven electron analogue: L.J. Haworth and E.L. VanHorn letters; Original G.K. Green outline for report; General description; Parameter list; Mechanical Assembly; Alignment; Degaussing; Vacuum System; Injection System; The pulsed inflector; RF System; Ferrite Cavity; Pick-up electrodes and preamplifiers; Radio Frequency power amplifier; Lens supply; Controls and Power; and RF acceleration summary.

  14. Synthesis of D-nor steroid analogues

    Czech Academy of Sciences Publication Activity Database

    Slavíková, Barbora; Kudová, Eva

    2014-01-01

    Roč. 108, S2 (2014), s142 ISSN 0009-2770. [Conference on Isoprenoids /22./. 07.09.2014-10.09.2014, Praha] R&D Projects: GA TA ČR(CZ) TE01020028; GA ČR(CZ) GAP303/12/1464 Institutional support: RVO:61388963 Keywords : D-nor steroid analogues * patch clamp technique Subject RIV: CC - Organic Chemistry

  15. Reseau des polygones de bord des indicateurs de performance d ...

    African Journals Online (AJOL)

    La fonction maintenance hospitalière a des composantes spécifiques qui la rendent de plus en plus complexe et fastidieuse. La politique d'une maintenance biomédicale repose sur des piliers et des leviers propres à une meilleure exploitation des dispositifs médicaux dans un système de santé. Trois niveaux de leviers ...

  16. Impact des microcredits sur les conditions sociosanitaires des ...

    African Journals Online (AJOL)

    Cependant, très peu d'étude se focalisent sur leurs impacts réels sur les conditions de vies des bénéficiaires de leurs services. C'est à ce propos que la présente recherche se donne comme objectif de contribuer à une meilleure connaissance des impacts des microcrédits - un des services offert par les IMF - sur les ...

  17. Promouvoir l'entrepreneuriat inclusif des jeunes et des femmes ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le projet vise à analyser la contribution réelle et potentielle de l'entrepreneuriat inclusif au bien-être des jeunes et des femmes en Côte d'Ivoire, au Burkina Faso et au Kenya. Après un état des lieux de la pratique de l'entrepreneuriat inclusif dans chacun des pays ciblés, l'équipe de recherche étudiera son incidence sur ...

  18. New alloferon analogues: synthesis and antiviral properties.

    Science.gov (United States)

    Kuczer, Mariola; Majewska, Anna; Zahorska, Renata

    2013-02-01

    We have extended our study on structure/activity relationship studies of insect peptide alloferon (H-His-Gly-Val-Ser-Gly-His-Gly-Gln-His-Gly-Val-His-Gly-OH) by evaluating the antiviral effects of new alloferon analogues. We synthesized 18 alloferon analogues: 12 peptides with sequences shortened from N- or C-terminus and 6 N-terminally modified analogues H-X(1)-Gly-Val-Ser-Gly-His-Gly-Gln-His-Gly-Val-His-Gly-OH, where X(1) = Phe (13), Tyr (14), Trp (15), Phg (16), Phe(p-Cl) (17), and Phe(p-OMe) (18). We found that most of the evaluated peptides inhibit the replication of Human Herpesviruses or Coxsackievirus B2 in Vero, HEp-2 and LLC-MK(2) cells. Our results indicate that the compound [3-13]-alloferon (1) exhibits the strongest antiviral activity (IC(50) = 38 μM) among the analyzed compound. Moreover, no cytotoxic activity against the investigated cell lines was observed for all studied peptides at concentration 165 μM or higher. © 2012 John Wiley & Sons A/S.

  19. La fabrique des sciences des institutions aux pratiques

    CERN Document Server

    Benninghoff, Martin; Crettaz von Roten, Fabienne; Merz, Martina

    2006-01-01

    Aujourd'hui, les façons de produire, d'organiser, d'évaluer et d'utiliser les savoirs sont en profond débat. De plus en plus, l'Etat, la société civile et l'économie tentent d'influencer les activités des universités et des laboratoires de recherche. Ces développements mettent à l'épreuve tout à la fois les fondements des systèmes d'enseignement supérieur et de recherche, l'autonomie des institutions scientifiques, la définition des frontières des savoirs et l'acceptation des sciences. Dans des contextes suisses et européens, cet ouvrage s'intéresse aux manières dont les sciences et les technologies sont fabriquées, en analysant leurs institutions et les pratiques. A partir d'une approche relationnelle, les sciences et les technologies sont conçues comme des phénomènes profondément sociaux, culturels et politiques. Une telle démarche déstabilise les visions parfois idéalisées et stéréotypées de la construction des savoirs. Des études de cas détaillées décrivent des phénomè...

  20. Effets des extraits vegetaux sur la dynamique de populations des ...

    African Journals Online (AJOL)

    La présente étude se propose de trouver une alternative de l'utilisation des pesticides chimiques en testant l'effet insecticide des extraits aqueux des feuilles de Hyptis suaveolens, graines de Ricinus communis et de Azadirachta indica contre les ravageurs du niébé en conditions de champ en utilisant le cyperméthrine ...

  1. Les lueurs des sables

    CERN Multimedia

    Les lueurs des sables

    2013-01-01

    Two CERN ladies are getting ready for the “Trophée Roses des Sables” rally adventure: Julie and Laetitia are finalizing the last details before setting off on Monday 7th October 2013. Julie from EN-MEF group and Laetitia from DGS-SEE group, met at the CERN Rugby club. This year, they are participating in the 100 % female rally which will take place in Morocco from 10 to 20 October. They will be carrying along 100 kg of humanitarian donation for children such as some clothes, books and medical material. Do not hesitate to show your support at their farewell party to be held on Monday 7 October, from 4 to 6 pm in front of the St Genis-Pouilly Mairie (city Hall). Follow their exciting adventure on the blog leslueursdessables.trophee-roses-des-sables.org and on their association’s Facebook page Les Lueurs des Sables.

  2. Analogue to Digital and Digital to Analogue Converters (ADCs and DACs): A Review Update

    CERN Document Server

    Pickering, J.

    2015-06-15

    This is a review paper updated from that presented for CAS 2004. Essentially, since then, commercial components have continued to extend their performance boundaries but the basic building blocks and the techniques for choosing the best device and implementing it in a design have not changed. Analogue to digital and digital to analogue converters are crucial components in the continued drive to replace analogue circuitry with more controllable and less costly digital processing. This paper discusses the technologies available to perform in the likely measurement and control applications that arise within accelerators. It covers much of the terminology and 'specmanship' together with an application-oriented analysis of the realisable performance of the various types. Finally, some hints and warnings on system integration problems are given.

  3. Screening phytochimique et identification spectroscopique des ...

    African Journals Online (AJOL)

    Le screening phytochimique des feuilles et des fleurs de cette plante, effectuée pour la première fois, a révélé la présence des alcaloïdes, des flavonoïdes, des tanins catéchiques, des terpènes, des coumarines et des composés cyanogénétiques. Quant aux saponines et les quinones libres, ils sont présents chez les fleurs ...

  4. Direction des Publications

    African Journals Online (AJOL)

    Synthese

    Résumé. Dans ce travail, on s‟intéresse à l‟effet des concentrations du xanthane, du caséinate de sodium et du tween 20 sur les propriétés rhéologiques, ... macromolécules des deux biopolymères, par effet du volume exclu, auquel cas, les ..... 25 (4), 743-749. [8] Gast A.P., Hall C.K., Russel W.B.,. 1983. Polymer-induced ...

  5. Liste des tableaux

    OpenAIRE

    2014-01-01

    1 – Importations en charbon américain en Europe de l’Ouest de 1946 à 1958 .47 2 – Organisation des demandes d’allocations de charbon allemand auprès de l’eco. 75 3 – Consommations de charbon allemand dans les zones occidentales de l’Allemagne d’octobre à décembre 1945. 86 4 – Production, exportations et consommation nationale apparente du charbon allemand dans la zone britannique en 1945 et 1946. 90 5 – Total des importations de charbons allemand et américain de janvier à avril 1946. 99 6 – I...

  6. Table des tableaux

    OpenAIRE

    2018-01-01

    Tableau 1 : Production nationale d'alcool avant 1919 68 Tableau 2 : Production nationale d'alcool après 1939 (Source : Martraire, 1955, A.D. 77 : Az 7086) 71 Tableau 3 : Les surfaces agricoles disponibles en France en 2004 123 Tableau 4 : Le régime fiscal des carburants et des biocarburants en 2005 et 2006 (source : ADEME) 175 Tableau 5 : Exemple de coût de production de biocarburants (Source : Stéphane His (IFP), Les biocarburants en Europe, 2004) 176 Tableau 6 : L’application de la directiv...

  7. Évaluation des pratiques agricoles des légumes feuilles : le cas des ...

    African Journals Online (AJOL)

    Face à ce constat, le défi de la recherche serait la détermination du niveau actuel de contamination des légumes feuilles et des eaux du barrage et celui de l'État serait l'initiation de programmes de sensibilisation des producteurs par rapport à une gestion plus rigoureuse des pesticides. Mots-clés : pratiques paysannes, ...

  8. Identification et surveillance des individus

    OpenAIRE

    Aghroum, Christian; Alberganti, Michel; Bonelli, Laurent; Ceyhan, Ayse; Denis, Vincent; Dufief, Vincent; Laurent, Sébastien; Piazza, Pierre; Preuss-Laussinotte, Sylvia; Rousselin, Thierry; Thorel, Jérôme; Tsoukala, Anastassia; Vitran, Jean-Claude; Alberganti, Michel; Alberganti, Michel

    2014-01-01

    « Big Brother is watching you ! » Cet avertissement placardé sur les murs de la cité imaginaire d'Océania dans le roman 1984 de Georges Orwell peut-il s'appliquer à nos sociétés contemporaines ? Passeport biométrique, fichage informatisé des individus, multiplication des caméras de surveillance, utilisation de puce dans des objets de la vie quotidienne, ou pour suivre les criminels en liberté surveillée, les mesures d'identification, de fichage et de surveillance des individus par des techniq...

  9. The Greenland analogue project. Yearly report 2010

    International Nuclear Information System (INIS)

    Harper, J.; Brinkerhoff, D.; Johnson, J.; Ruskeeniemi, T.; Engstroem, J.; Kukkonen, I.

    2012-04-01

    A four-year field and modelling study of the Greenland ice sheet and subsurface conditions, Greenland Analogue Project (GAP), has been initiated collaboratively by SKB, Posiva and NWMO to advance the understanding of processes associated with glaciation and their impact on the long-term performance of a deep geological repository. The study site encompasses a land terminus portion of the Greenland ice sheet, east of Kangerlussuaq, and is in many ways considered to be an appropriate analogue of the conditions that are expected to prevail in much of Canada and Fennoscandia during future glacial cycles. The project begins in 2009 and is scheduled for completion in 2012. Our current understanding of the hydrological, hydrogeological and hydrogeochemical processes associated with cold climate conditions and glacial cycles, and their impact on the long-term performance of deep geological repositories for spent nuclear fuel, will be significantly improved by studying a modern analogue. The GAP will conduct the first in situ investigations of some of the parameters and processes needed to achieve a better understanding of how an ice sheet may impact a deep repository, and will provide measurements, observations and data that may significantly improve our safety assessments and risk analyses of glaciation scenarios. This report was produced by the GAP team members and presents an overview of the activities within the GAP during the interval January 1 to December 31, 2010, as well as research results obtained during this time frame. Research for the GAP is ongoing, and additional results related to the data presented here may become available in the future and will be presented in subsequent annual reports. (orig.)

  10. The Greenland analogue project. Yearly report 2010

    Energy Technology Data Exchange (ETDEWEB)

    Harper, J.; Brinkerhoff, D.; Johnson, J. [University of Montana, Missoula (United States); Ruskeeniemi, T.; Engstroem, J.; Kukkonen, I. [Geological Survey of Finland (Finland)] [and others

    2012-04-15

    A four-year field and modelling study of the Greenland ice sheet and subsurface conditions, Greenland Analogue Project (GAP), has been initiated collaboratively by SKB, Posiva and NWMO to advance the understanding of processes associated with glaciation and their impact on the long-term performance of a deep geological repository. The study site encompasses a land terminus portion of the Greenland ice sheet, east of Kangerlussuaq, and is in many ways considered to be an appropriate analogue of the conditions that are expected to prevail in much of Canada and Fennoscandia during future glacial cycles. The project begins in 2009 and is scheduled for completion in 2012. Our current understanding of the hydrological, hydrogeological and hydrogeochemical processes associated with cold climate conditions and glacial cycles, and their impact on the long-term performance of deep geological repositories for spent nuclear fuel, will be significantly improved by studying a modern analogue. The GAP will conduct the first in situ investigations of some of the parameters and processes needed to achieve a better understanding of how an ice sheet may impact a deep repository, and will provide measurements, observations and data that may significantly improve our safety assessments and risk analyses of glaciation scenarios. This report was produced by the GAP team members and presents an overview of the activities within the GAP during the interval January 1 to December 31, 2010, as well as research results obtained during this time frame. Research for the GAP is ongoing, and additional results related to the data presented here may become available in the future and will be presented in subsequent annual reports. (orig.)

  11. Natural Analogues of CO2 Geological Storage

    International Nuclear Information System (INIS)

    Perez del Villar, L.; Pelayo, M.; Recreo, F.

    2007-01-01

    Geological storage of carbon dioxide is nowadays, internationally considered as the most effective method for greenhouse gas emission mitigation, in order to minimize the global climate change universally accepted. Nevertheless, the possible risks derived of this long-term storage have a direct influence on its public acceptance. Among the favourable geological formations to store CO2, depleted oil and gas fields, deep saline reservoirs, and unamiable coal seams are highlighted. One of the most important objectives of the R and D projects related to the CO2 geological storage is the evaluation of the CO2 leakage rate through the above mentioned geological formations. Therefore, it is absolutely necessary to increase our knowledge on the interaction among CO2, storage and sealing formations, as well as on the flow paths and the physical resistance of the sealing formation. The quantification of the CO2 leakage rate is essential to evaluate the effects on the human and animal health, as well as for the ecosystem and water quality. To achieve these objectives, the study of the natural analogues is very useful in order to know the natural leakage rate to the atmosphere, its flow paths, the physical, chemical and mineralogical modifications due to the long term interaction processes among the CO2 and the storage and sealing formations, as well as the effects on the groundwaters and ecosystems. In this report, we have tried to summarise the main characteristics of the natural reservoirs and surficial sources of CO2, which are both natural analogues of the geological storage and CO2 leakage, studied in EEUU, Europe and Australia. The main objective of this summary is to find the possible applications for long-term risk prediction and for the performance assessment by means of conceptual and numerical modelling, which will allow to validate the predictive models of the CO2 storage behaviour, to design and develop suitable monitoring techniques to control the CO2 behaviour

  12. Nuclear waste geochemistry: natural and anthropic analogues

    International Nuclear Information System (INIS)

    Petit, J.C.

    1997-01-01

    The geochemical evolution of nuclear waste storage is difficult to describe, due to the long time scales involved, the radioactivity confinement complexity and the un-natural radionuclides which evolution is not known. In order to carry out a long term prediction, a special approach is used, based on a combination of experiments conducted in laboratories and in situ, modelizations and comparisons with process and material analogues (natural or man-made, such as basaltic and rhyolitic volcanic glasses, plutonium, historical and archaeological artefacts)

  13. Somatostatin analogue scintigraphy in granulomatous diseases

    Energy Technology Data Exchange (ETDEWEB)

    Vanhagen, P.M. (Dept. of Internal Medicine 3, Dijkzigt Univ. Hospital, Rotterdam (Netherlands) Dept. of Immunology, Dijkzigt Univ. Hospital, Rotterdam (Netherlands)); Krenning, E.P. (Dept. of Internal Medicine 3, Dijkzigt Univ. Hospital, Rotterdam (Netherlands) Dept. of Nuclear Medicine, Dijkzigt Univ. Hospital, Rotterdam (Netherlands)); Reubi, J.C. (Inst. of Pathology, Bern Univ. (Switzerland)); Kwekkeboom, D.J. (Dept. of Nuclear Medicine, Dijkzigt Univ. Hospital, Rotterdam (Netherlands)); Bakker, W.H. (Dept. of Nuclear Medicine, Dijkzigt Univ. Hospital, Rotterdam (Netherlands)); Mulder, A.H. (Dept. of Pathology, Dijkzigt Univ. Hospital, Rotterdam (Netherlands)); Laissue, I. (Inst. of Pathology, Bern Univ. (Switzerland)); Hoogstede, H.C. (Dept. of Chest Medicine, Dijkzigt Univ. Hospital, Rotterdam (Netherlands)); Lamberts, S.W.J. (Dept. of Internal Medicine 3, Dijkzigt Univ. Hospital, Rotterdam (Netherlands))

    1994-06-01

    In the present study 20 consecutive patients were investigated, 12 with sarcoidosis, one with both sarcoidosis and aspergillosis, four with tuberculosis and three with Wegener's granulomatosis. For in vivo SS-R imaging, total-body scintigraphy was performed 24 and 48 h after the administration of [sup 111]In-octreotide. Granuloma localizations could be visualized in all patients studied; additional sites were found in nine patients with sarcoidosis and in two patients with tuberculosis. In vitro autoradiography of fresh tissue biopsies, using the SS analogue [[sup 125]I-Tyr[sup 3

  14. La structure des solutions aqueuses

    Science.gov (United States)

    Powell, D. H.

    2003-09-01

    En commençant par l'étude par diffraction neutronique de la structure des liquides moléculaires puis de l'hydratation des ions en solution, ce cours montrera comment les principes présentés lors des cours précédents peuvent être appliqués à des systèmes aqueux. Des exemples tirés de la littérature seront utilisés pour illustrer les considérations expérimentales propre à ce domaine et le genre d'informations que nous pouvons obtenir. Ce cours montrera également l'applicaton de la diffraction neutronique à des systèmes d'intérêt biologique et environnemental et se terminera par un examen de la complémentarité fournie par la diffraction des rayons X, l'EXAFS et la RMN.

  15. peste des petits ruminants

    African Journals Online (AJOL)

    HP USER

    Diallo A, Minet C, Le Goff C, Berhe G, Albina E, Libeau. G, Barrett T (2007). The threat of peste des petits ruminants: progress in vaccine development for disease control. Vaccine. 25:5591–5597. Esuruoso GO (1995). The practice of preventive veterinary medicine in a devastated national economy. Being the text of an.

  16. Investir dan des solutions

    International Development Research Centre (IDRC) Digital Library (Canada)

    Gestion du risque. La gestion du risque est une responsabilité partagée entre les gestionnaires du Centre qui est intégrée à tous les processus administratifs importants. .... que préconisent les Normes internationales d'information financière (normes IFRS). TABLEAU 2. RÉPARTITION DES PRODUITS. Crédit parlementaire.

  17. Direction des Publications

    African Journals Online (AJOL)

    Synthese

    Plusieurs études cliniques et épidémiologiques ont montré que le diabète est associé à cette ... CMLs responsables de la modulation des fibroblastes en ..... Pagano P.J., 2004. Gene transfer of. NAD(P)H oxidase inhibitor to the vascular adventitia attenuates medial smooth muscle hypertrophy. Circ. Res., 95, 587-. 594.

  18. Praxis des Klebens

    CERN Document Server

    Theuerkauff, Petra

    1989-01-01

    Bei diesem Buch handelt es sich um einen Leitfaden fur Klebepraktiker. Es werden die verschiedenen Einzelschritte beim kleben beschrieben, als auch die vorbereitenden Massnahmen und anschliessenden Prufverfahren auf Festigkeit behandelt. Das Buch sollte an keinem Arbeitsplatz fehlen, wo man sich mit Problemen der Fugetechnik des Klebens beschaftigt.

  19. La physique des infinis

    CERN Document Server

    Bernardeau, Francis; Laplace, Sandrine; Spiro, Michel

    2013-01-01

    Écrire l'histoire de l'Univers, tel est l'objectif commun des physiciens des particules et des astrophysiciens. Pour y parvenir, deux approches s'épaulent : la voie de l'infiniment petit, que l'on emprunte via de gigantesques accélérateurs de particules, et celle de l'infiniment grand, dont le laboratoire est l'Univers. Un Univers qui est bien loin d'avoir livré tous ses secrets. On connaît à peine 4,8 % de la matière qui le constitue, le reste étant composé de matière noire (25,8 %) et d'énergie noire (69,4 %), toutes deux de nature inconnue. Et si la récente découverte du boson de Higgs valide le Modèle standard de la physique des particules, celui-ci est toujours incomplet et doit être étendu à ou dépassé. Est-on arrivé au bout du jeu de poupées russes de la matière ? Quelles sont les particules manquantes ? Faut-il revoir les lois fondamentales ? Quels instruments faut-il mettre en œuvre pour accéder à cette « nouvelle physique » ? Comment parler de Super Big Science aux citoye...

  20. REPRISE DES COURS - Yoga

    CERN Multimedia

    Club de Yoga

    2015-01-01

    REPRISE DES COURS – Venez nombreux ! Yoga, Sophrologie, Tai Chi La liste des cours pour le semestre allant du 1er septembre 2015 au 31 janvier 2016 est disponible sur notre site web : http://club-yoga.web.cern.ch Lieu Les cours ont lieu dans la salle des clubs, à l’entresol du restaurant No 2, Bât. 504 (dans la salle no 3 pour la Sophrologie). Prix des cours Le prix pour le semestre (environ 18 leçons) est fixé à 220 CHF plus 10 CHF d’adhésion annuelle au Club. Couple : 200 CHF par personne. 2 cours par semaine : 400 CHF. Inscriptions Les inscriptions aux cours seront prises directement auprès du professeur, lors de la 1ère séance. Avant de s’inscrire pour le semestre, il est possible d’essayer une séance gratuitement. Informations : http://club-yoga.web.cern.ch ----------------------------------------- cern.ch/club-yoga/

  1. Recevabilité des communications par la Commission africaine des droits de l’homme et des peuples

    OpenAIRE

    Nguema, Nisrine Eba

    2014-01-01

    La Commission africaine des droits de l’homme et des peuples constitue le principal organe de protection des droits de l’homme en Afrique. Mise en place en 1987, elle a pour mission principale de recevoir les communications des victimes des violations des droits de l’homme. L’ouverture de la procédure de traitement des communications individuelles devant la Commission africaine est conditionnée par le respect des conditions posée par l’article 56 de la Charte africaine des droits de l’homme e...

  2. U.S. Nuclear Regulatory Commission natural analogue research program

    International Nuclear Information System (INIS)

    Kovach, L.A.; Ott, W.R.

    1995-01-01

    This article describes the natural analogue research program of the U.S. Nuclear Regulatory Commission (US NRC). It contains information on the regulatory context and organizational structure of the high-level radioactive waste research program plan. It also includes information on the conditions and processes constraining selection of natural analogues, describes initiatives of the US NRC, and describes the role of analogues in the licensing process

  3. Injectabilite des coulis de ciment dans des milieux fissures

    Science.gov (United States)

    Mnif, Thameur

    Le travail presente ici est un bilan du travaux de recherche effectues sur l'injectabilite des coulis de ciment dans lu milieux fissures. Un certain nombre de coulis a base de ciment Portland et microfin ont ete selectionnes afin de caracteriser leur capacite a penetrer des milieux fissures. Une partie des essais a ete menee en laboratoire. L'etude rheologique des differents melanges a permis de tester l'influence de l'ajout de superplastifiant et/ou de fumee de silice sur la distribution granulometrique des coulis et par consequent sur leur capacite a injecter des colonnes de sable simulant un milieu fissure donne. La classe granulometrique d'un coulis, sa stabilite et sa fluidite sont apparus comme les trois facteurs principaux pour la reussite d'une injection. Un facteur de finesse a ete defini au cours de cette etude: base sur la classe granulometrique du ciment et sa stabilite, il peut entrer dans la formulation theorique du debit d'injection avant application sur chantier. La deuxieme et derniere partie de l'etude presente les resultats de deux projets de recherche sur l'injection realises sur chantier. L'injection de dalles de beton fissurees a permis le suivi de l'evolution des pressions avec la distance au point d'injection. L'injection de murs de maconnerie a caractere historique a montre l'importance de la definition de criteres de performance des coulis a utiliser pour traiter un milieu donne et pour un objectif donne. Plusieurs melanges peuvent ainsi etre predefinis et mis a disposition sur le chantier. La complementarite des ciments traditionnels et des ciments microfins devient alors un atout important. Le choix d'utilisation de ces melanges est fonction du terrain rencontre. En conclusion, cette recherche etablit une methodologie pour la selection des coulis a base de ciment et des pressions d'injection en fonction de l'ouverture des fissures ou joints de construction.

  4. The Orléans-Lithothèque - an analogue rockstore for in situ missions

    Science.gov (United States)

    Bost, Nicolas; Westall, Frances; Ramboz, Claire

    2010-05-01

    The Orléans-Lithothèque - an analogue rockstore for in situ missions Nicolas Bost, Frances Westall, Claire Ramboz, Axelle Hubert, Derek Pullan, Beda Hofmann, Elisabeth Vergès, Michel Viso, Jorge Vago, Christelle Briois, Bruno Scaillet, Michel Tagger Instruments for in-situ missions to extraterrestrial bodies should ideally be cross calibrated using a common suite of relevant materials. Such multi-instrument calibration would enable a better comparison of instrument performances during the mission, as well as aid in the interpretation of the in-situ measurements. At the CNRS in Orléans, the Observatoire des Sciences de l'Univers de la region Centre is creating a collection of well-characterised rocks that will be available for testing and calibrating instruments to be flown on space missions. The characteristics of the collection's analogue materials will be described in an online database. In view of the upcoming 2018 ExoMars rover mission, we are concentrating initially on materials of direct relevance to Mars. The initial collection includes basalts (ultramafic, weathered, andesitic, hydrothermally-silicified); sediments (volcanic, biolaminated, banded iron formation); and minerals (silica, evaporites, clays, Fe oxides). This set of samples will be augmented with time. All samples will be characterised petrographically, petrologically, and geochemically using the types of analyses likely to be performed during an in-situ mission: hand specimen description, optical microscopy, mineralogical analysis (XRD, Raman and IR spectrometry), elemental analysis (EDX, microprobe, ICP) and organics analysis (Raman, pyr-GCMS).

  5. Ways to Optimize Analogue Switched Circuits

    Directory of Open Access Journals (Sweden)

    J. Hospodka

    2008-12-01

    Full Text Available This paper describes how analogue switched circuits (switched-capacitor and switched-current circuits can be optimized by means of a personal computer. The optimization of this kind of circuits is not so common and their analysis is more difficult in comparison with continuously working circuits. Firstly, the nonidealities occurring in these circuits whose effect on their characteristics should be optimized are discussed. Then a few ways to analyze analogue switched circuits are shown. From all optimization algorithms applicable for this kind of optimization, two ones that seem to be the most promising are proposed. The differential evolution (one of evolutionary algorithms combined with the simplex method was found to be most appropriate from these two ones. Two types of programs are required for the optimization of these circuits: a program for implementing calculations of the used optimization algorithm and a program for the analysis of the optimized circuit. Several suitable computer programs from both of the groups together with their proper settings according to authors’ experience are proposed. At the end of the paper, an example of a switched-current circuit optimization documenting the previous description is presented.

  6. Andrographolide and analogues in cancer prevention.

    Science.gov (United States)

    Mishra, Siddhartha Kumar; Tripathi, Swati; Shukla, Archana; Oh, Seung Hyun; Kim, Hwan Mook

    2015-01-01

    Andrographis paniculata is a medicinal plant traditionally used for treatment of cough and cold, fever, laryngitis, and several infectious diseases. Extracts of A. paniculata have shown versatile potency against various diseases including cancer. The active biomolecules of A. paniculata mainly are lactone and diterpene. Andrographolide and analogues have been widely used for prevention of different diseases. Andrographolides have shown potent antiinflammatory and anticancer activities. It showed potentials as chemopreventive agents by suppressing growth of cancer cells by inhibiting NF-kappaB, PI3K/AKT and other kinase pathways and by inducing apoptosis. Andrographolide induced both intrinsic and extrinsic apoptosis pathway in different cancer cells via expression of different anti-apoptotic protein like Bax, p53, and activated caspases. Andrographolide was successfully used as an antineoplastic drug in cancer chemotherapy. Andrographolide inhibited the growth of human breast, prostate, and hepatoma tumors. Andrographolide and analogues need to be subjected to further clinical and biomedical studies in cancer chemoprevention. Andrographolide could be potent anticancer agent when used in combination with other chemotherapeutic agents.

  7. Utilisation des cahiers d'activites dans l'enseignement des sciences ...

    African Journals Online (AJOL)

    Les résultats des entretiens ont mis en exergue des sujets comme l'utilisation abusive des CA par certains enseignants, l'imposition des CA aux apprenants et leur coût, la qualité des contenus des CA et le maintien ou la suppression de la production des CA. D'autre part, le rendement scolaire des apprenants a été ...

  8. Efficacité des néonicotinoïdes et des pyréthrinoïdes utilisés contre le ...

    African Journals Online (AJOL)

    Efficacité des néonicotinoïdes et des pyréthrinoïdes utilisés contre le foreur des tiges du cacaoyer ( Eulophonotus myrmeleon Felder : Lepidoptera, Cossidae). Implications dans la stratégie de protection de la cacaoculture en Côte d'Ivoire.

  9. Dopage et protection des jeunes sportifs : Loin des affaires

    OpenAIRE

    Guy, Daniel

    2002-01-01

    National audience; Loin des affaires et des révélations polémiques de la presse, les jeunes plébiscitent massivement les activités sportives. Sport compétition, sport participation, sport détente... Pourtant, quand la pratique devient intense, que les entraînements et les compétitions s'enchaînent à un rythme soutenu, l'ombre des conduites dopantes vient déchirer la quiétude des uns et des autres. Or, que savons-nous réellement de la pratique des jeunes sportifs ? Comment préparent-ils les co...

  10. Aspects des Onychomycoses chez des patients camerounais de ...

    African Journals Online (AJOL)

    ... biologiques et évolutifs des onychomycoses chez des patients camerounais. Méthode : Il s'agit d'une étude rétrospective et descriptive menée de mars 2011 à mars 2014 dans l'unité de dermatologie de l'hôpital général de Douala (HGD), incluant des patients chez lesquels le diagnostic d'onychomycose avait été posé.

  11. Des dispositions responsables à prendre pour la protection des ...

    African Journals Online (AJOL)

    En considérant l'effet néfaste des maladies, des parasites, du changement climatique et d'autres facteurs environnementaux (les OGM par exemple) sur la survie des abeilles, la baisse de leurs populations dans certaines parties du monde ne saurait être attribuée aux seules pesticides. En plus, l'impact de ces derniers sur ...

  12. Collection d'entretiens avec des chercheurs participant à des ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2014-07-07

    Jul 7, 2014 ... Entretien avec…propose des entrevues vidéos avec des chercheurs participant à des projets portant sur l'adaptation aux changements climatiques réalisés en Afrique, en Asie ainsi qu'en Amérique latine et dans les Caraïbes que le CRDI subventionne par le truchement de son programme Changements ...

  13. Etat des controverses des approches cognitive et ecologique en ...

    African Journals Online (AJOL)

    Cette revue de question vise à présenter dans le champ de l'apprentissage moteur, le sens des postulats des approches cognitive et écologique de même que les critiques formulées à leur encontre. Des documents scientifiques et articles de revues indexées et publiés dans la banque de données MEDLINE, ont été ...

  14. Space Analogue Environments: Are the Populations Comparable?

    Science.gov (United States)

    Sandal, G. M.

    Background: Much of our present understanding about psychology in space is based on studies of groups operating in so-called analogue environments where personnel are exposed to many of the same stressors as those experienced by astronauts in space. One possible problem with extrapolating results is that personnel operating in various hazardous and confined environments might differ in characteristics influencing coping, interaction, and performance. The object of this study was to compare the psychological similarity of these populations in order to get a better understanding of whether this extrapolation is justifiable. The samples investigated include polar crossings (N= 22), personnel on Antarctic research stations (N= 183), several military occupations (N= 187), and participants in space simulation studies (N=20). Methods: Personnel in each of these environments were assessed using the Personality Characteristic Inventory (PCI) and Utrecht Coping List (UCL). The PCI is a multidimensional trait assessment battery that measures various aspects of achievement orientation and social competence. The UCL is a questionnaire designed to assess habitual coping strategies when encountering stressful or demanding situations. Results: Only minor differences in use of habitual coping strategies were evident across the different samples. In relation to personality scores, the military subjects and participants in space simulation studies indicated higher competitiveness and negative instrumentality compared to both the personnel on Antarctic research stations and participants in polar expedition. Among the personnel on Antarctic research stations, significant gender differences were found with women scoring lower on competitiveness, negative instrumentality and impatience/irritability. Compared to the other samples, the participants in polar expeditions were found to be more homogeneous in personality and no significant gender differences were evident on the traits that

  15. Fourrages ligneux des savanes du Tchad : Etat actuel des ...

    African Journals Online (AJOL)

    Une meilleure méthode d'aménagement et de gestion des ligneux fourragers en vue de leur utilisation optimale a été proposée. Mots clés ...... Toutefois, la présence massive des rejets de souches observée au niveau des classes supérieures à [0-0,5 m[ est une forme d'adaptation et une stratégie de survie des espèces ...

  16. Direction des Publications

    African Journals Online (AJOL)

    Synthese

    Unité de Recherche des Matériaux et des Energies Renouvelables (U.R.M.E.R). Université Abou –Baker Belkaid B.p : 119 Tlemcen 13000 Algerie. 2. Unité de Développement de la Technologie Du Silicium. UDTS, BP 399, Alger, Algérie. Accepté le : 08/06/2011. صخلم. داوﻣﻟا نﻣ ﻲﺗﻟا ﺔﺻﺎﺧو ،ﺔﻋﺎﻧﺻ يأ رﯾوطﺗ ﻲﻓ ﺎﯾﺳﯾﺋر ﻼﻣﺎﻋ ةرﯾﺧﻷا تاوﻧﺳﻟا ...

  17. Table des tableaux

    OpenAIRE

    2017-01-01

    1. District de l’Inquisition de Tolède. Distances depuis le siège 19 2. District de l’Inquisition de Tolède. Répartition de la population par régions géographiques en 1591 24 3. District de l’Inquisition de Tolède. Évolution de la population au XVIe siècle par régions géographiques 25 4. Inquisition de Tolède. Origine des étrangers vieux-chrétiens jugés par le tribunal 27 5. Inquisition de Tolède. Répartition des clercs selon le type d’agglomération 55 6. District de l’Inquisition de Tolède, ...

  18. Liste des figures

    OpenAIRE

    2015-01-01

    Claudine Fabre-Vassas, Identification d'un rite 1. Ordonnance de 1779 interdisant «la méthode de guérir les hernies par la castration» 66 Christian Bromberger, Pour une ethnologie du spectacle sportif 1. La popularité relative de deux vedettes de l'Olympique de Marseille 228 2. Répartition des spectateurs marseillais dans le stade d'après leur origine résidentielle 232

  19. Direction des Publications

    African Journals Online (AJOL)

    Synthese

    7 sept. 2011 ... D‟autre part une approche statistique sera menée à partir de l‟analyse en composantes principales (ACP) afin de déterminer les processus géochimiques responsables de l‟évolution de la salinité des sols. 2. Matériel et méthodes. 2.1 Cadre physique. Le lac Fetzara est situé à 18 km au Sud-. Ouest de ...

  20. Direction des Publications

    African Journals Online (AJOL)

    Synthese

    Notre objectif est d‟élaborer des couches minces en Fe-Si par copulvérisation cathodique magnétron à différent pourcentage de silicium dans une atmosphère inerte d‟Argon et de les caractériser du point de vue physique. (composition chimique, microstructure…). Ces couches peuvent servir comme capteur magnétique.

  1. Des Ogle's old stump

    International Nuclear Information System (INIS)

    Jones, M.; Sutton, D.; Wallace, R.

    1998-01-01

    On 17 October 1997 Sylvia Bryan of RD4 Kaitaia wrote to 'Dear Somebody-Everybody' at the Anthropology Department, University of Auckland, urging further examination of an adzed stump found by Des Ogle during planting out of the Te Aupouri forest. The authors have since sought out relevant information and present it here for the interests of our readers. (author). 7 refs., 1 fig

  2. Jupiter analogues and planets of active stars

    Directory of Open Access Journals (Sweden)

    Henning T.

    2013-04-01

    Full Text Available Combined results are now available from a 15 year long search for Jupiter analogues around solar-type stars using the ESO CAT + CES, ESO 3.6 m + CES, and ESO 3.6 m + HARPS instruments. They comprise planet (co-discoveries (ι Hor and HR 506 and confirmations (three planets in HR 3259 as well as non-confirmations of planets (HR 4523 and ɛ Eri announced elsewhere. A long-term trend in ɛ Ind found by our survey is probably attributable to a Jovian planet with a period >30 yr, but we cannot fully exclude stellar activity effects as the cause. A 3.8 year periodic variation in HR 8323 can be attributed to stellar activity.

  3. The gravitational analogue of the Witten effect

    International Nuclear Information System (INIS)

    Foda, O.

    1984-06-01

    In the presence of massive fermions, and assuming a non-vanishing theta-parameter as the only source of CP-violation, the Witten effect [a shift in the electric charge of a magnetic monopole due to CP-non-conservation] is shown to follow from an anomalous chiral commutator. Next, given the gravitational contribution to the chiral anomaly, the corresponding anomalous commutator for Dirac fermion currents in a gravitational background is derived. From that, we infer the equivalence of a theta R-tilde R term in the Lagrangian to a shift in the mass parameter of the NUT metric, in proportion to theta. This is interpreted as the gravitational analogue of the Witten effect. Its relevance to certain Kaluza-Klein monopoles is briefly discussed. (author)

  4. Gravitational analogue of the Witten effect

    Energy Technology Data Exchange (ETDEWEB)

    Foda, O. (International Centre for Theoretical Physics, Trieste (Italy))

    1985-07-22

    In the presence of massive fermions, and assuming a non-vanishing theta-parameter as the only source of CP violation, the Witten effect (a shift in the electric charge of a magnetic monopole due to CP non-conservation) is shown to follow from an anomalous chiral commutator. Next, given the gravitational contribution to the chiral anomaly, the corresponding anomalous commutator for Dirac fermion currents in a gravitational background is derived. From that, we infer the equivalence of a thetaR tildeR term in the lagrangian to a shift in the mass parameter of the NUT metric, in proportion to theta. This is interpreted as the gravitational analogue of the Witten effect. Its relevance to certain Kaluza-Klein monopoles is briefly discussed.

  5. The gravitational analogue of the Witten effect

    International Nuclear Information System (INIS)

    Foda, O.

    1985-01-01

    In the presence of massive fermions, and assuming a non-vanishing theta-parameter as the only source of CP violation, the Witten effect (a shift in the electric charge of a magnetic monopole due to CP non-conservation) is shown to follow from an anomalous chiral commutator. Next, given the gravitational contribution to the chiral anomaly, the corresponding anomalous commutator for Dirac fermion currents in a gravitational background is derived. From that, we infer the equivalence of a thetaR tildeR term in the lagrangian to a shift in the mass parameter of the NUT metric, in proportion to theta. This is interpreted as the gravitational analogue of the Witten effect. Its relevance to certain Kaluza-Klein monopoles is briefly discussed. (orig.)

  6. Reflective analogue optical link operating issues

    CERN Document Server

    Batten, Jeremy

    1996-01-01

    The proposed readout of analogue data from CMS tracker will use an optical fibre link. The choice of transmitter/receiver technology, however, has been the subject of intense research and development by the RD23 collaboration. One solution uses passive devices, multi-quantum well modulators, at the detector front end, and continuous wave driving lasers at the readout back end. This system has been tested at Imperial College. We report on the following: problems of noise associated with multimoded behaviour of a degraded laser; measurements of laser wavelength dependence on both drive current and temperature; and modulator reflectance dependence on laser wavelength. We extrapolate the findings to system issues, highlighting the degree of temperature control required of the driving laser.

  7. The glaciogenic reservoir analogue studies project (GRASP)

    DEFF Research Database (Denmark)

    Moscariello, A.; Moreau, Julien; Vegt, P. van der

    increasing the risk associated with developing effectively these reservoirs. Therefore a analogue-based predictive stratigraphical and sedimentological model can help to steer drilling strategy and reduce uncertainties and associated risks. For this purpose the GRASP joint industry programme was established......Tunnel galleys are common features in Palaeozoic glacigenic succession in North Afrcica and Middle East and they are amongst the most challenging target for hydrocarbon exploration and developing drilling in these regions. Similarly, these buried valleys form important groundwater reservoirs...... in Quaternary glaciated areas and their nature and sediment composition is critical to drive a sustainable production strategy and assess their vulnerability. Seismic resolution however, often limits the understanding of channel valleys morphology, 3D geometry and internal reservoir distribution, thus...

  8. Dictionnaire des risques psychosociaux

    CERN Document Server

    Zawieja, Philippe

    2014-01-01

    Stress, suicide, harcèlement, épuisement professionnel, workaholism... Au-delà de la souffrance qu'elles désignent, ces notions souvent récentes constituent une approche inédite, et demandent à mieux être comprises, dans leur ensemble et isolément. C'est tout l'enjeu de ce dictionnaire, pionnier en son genre. Le lecteur y trouvera représentés, avec les 314 entrées (rédigées par 251 contributeurs) qui le composent, tous les champs disciplinaires s'intéressant à la souffrance au travail : psychologie du travail et des organisations, psychologie sociale et psychosociologie, psychanalyse, psychopathologie et psychiatrie, ergonomie, sociologie du travail et des organisations, médecine du travail, droit du travail et de la sécurité sociale, sciences de gestion, philosophie... Y sont détaillés les principaux concepts, notions, approches, méthodes, théories, outils, études, etc., ayant cours dans l'étude des risques psychosociaux, mais aussi certaines professions emblématiques (infirmières,...

  9. Synthesis of an Orthogonal Topological Analogue of Helicene

    DEFF Research Database (Denmark)

    Wixe, Torbjörn; Wallentin, Carl‐Johan; Johnson, Magnus T.

    2013-01-01

    The synthesis of an orthogonal topological pentamer analogue of helicene is presented. This analogue forms a tubular structure with its aromatic systems directed parallel to the axis of propagation, which creates a cavity with the potential to function as a host molecule. The synthetic strategy...

  10. Caged ceramide 1-phosphate analogues: synthesis and properties.

    Science.gov (United States)

    Lankalapalli, Ravi S; Ouro, Alberto; Arana, Lide; Gómez-Muñoz, Antonio; Bittman, Robert

    2009-11-20

    Sphingolipid phosphate analogues bearing 7-(diethylamino)coumarin (DECM) and 4-bromo-5-hydroxy-2-nitrobenzhydryl (BHNB) groups in a photolabile ester bond were synthesized. The ability of the "caged" ceramide 1-phosphate analogues to release the bioactive parent molecule upon irradiation at 400-500 nm was demonstrated by stimulation of macrophage cell proliferation.

  11. Automated Layout Generation of Analogue and Mixed-Signal ASIC's

    DEFF Research Database (Denmark)

    Bloch, Rene

    The research and development carried out in this Ph.D. study focusses on two key areas of the design flow for analogue and mixed-signal integrated circuit design, the mixed-signal floorplanning and the analogue layout generation.A novel approach to floorplanning is presented which provides true i...

  12. Uncertainties and credibility building of safety analyses. Natural analogues

    International Nuclear Information System (INIS)

    Laciok, A.

    2001-07-01

    The substance of natural analogues and their studies is defined as a complementary method to laboratory and in-situ experiments and modelling. The role of natural analogues in the processes of development of repositories is defined, mainly in performance assessment of repository system and communication with public. The criteria for identification of natural analogues which should be evaluated in the phase of initiation of new studies are specified. Review part of this report is divided to study of natural analogues and study of anthropogenic and industrial analogues. The main natural analogue studies performed in various countries, in different geological setting, with various aims are characterized. New results acquired in recently finished studies are included: Palmottu (2nd phase of project financed by European Commission), Oklo (results of research financed also by European Commission), Maqarin (3rd phase) and other information obtained from last meetings and workshops of NAWG. In view of the fact that programmes of development of deep repositories in Czech and Slovak Republics are interconnected, the natural analogues studies carried out in the Czech republic are incorporated in separate chapter - study of uranium accumulation in Tertiary clays at Ruprechtov site and study of degradation of natural glasses. In final part the areas of natural analogue studies as an integral part of development of deep geological repository are proposed along with characterization of broader context and aspects of realization of these studies (international cooperation, preparation and evaluation of procedures, communication with public). (author)

  13. Insulin analogues and severe hypoglycaemia in type 1 diabetes

    DEFF Research Database (Denmark)

    Kristensen, P L; Hansen, L S; Jespersen, M J

    2012-01-01

    The effect of insulin analogues on glycaemic control is well-documented, whereas the effect on avoidance of severe hypoglycaemia remains tentative. We studied the frequency of severe hypoglycaemia in unselected patients with type 1 diabetes treated with insulin analogues, human insulin, or mixed...

  14. MAQARIN natural analogue study: phase III

    Energy Technology Data Exchange (ETDEWEB)

    Alexander, W.R.; Mazurek, M.; Waber, H.N. [Univ. of Berne (Switzerland). Institutes of Geology, Mineralogy and Petrology, Rock-Water Interaction Group (GGWW); Arlinger, J.; Erlandson, A.C.; Hallbeck, L.; Pedersen, K. [Goeteborg University (Sweden). Dept. of General and Marine Microbiology; Boehlmann, W.; Fritz, P.; Geyer, S.; Geyer, W.; Hanschman, G.; Kopinke, F.D.; Poerschmann, J. [Umweltforschungszentrum Leipzig-Halle (Germany); Chambers, A.V.; Haworth, A.; Ilett, D.; Linklater, C.M.; Tweed, C.J. [AEA Technology plc, Harwell (United Kingdom); Chenery, S.R.N.; Kemp, S.J.; Milodowski, A.E.; Pearce, J.M.; Reeder, S.; Rochelle, C.A.; Smith, B.; Wetton, P.D.; Wragg, J. [British Geological Survey, Keyworth (United Kingdom); Clark, I.D. [Univ. of Ottawa (Canada). Dept. of Geology; Hodginson, E.; Hughes, C.R. [Univ. of Manchester (United Kingdom). Dept. of Earth Sciences; Hyslop, E.K. [British Geological Survey, Edinburgh (United Kingdom); Karlsson, F. [Swedish Nuclear Fuel and Waste Management Co., Stockholm (Sweden); Khoury, H.N.; Salameh, E. [Univ. of Jordan, Amman (Jordan); Lagerblad, B. [Cement Institute, Stockholm (Sweden); Longworth, G. [Univ. of Manchester (United Kingdom). Dept. of Geology; Pitty, A.F. [Private consultant, Norwich (United Kingdom); Savage, D. [QuantiSci Ltd, Melton Mowbray (United Kingdom); Smellie, J.A.T. [ed.] [Conterra AB, Uppsala (Sweden)

    1998-12-01

    This report represents the conclusion to Phase III of the Maqarin Natural Analogue Study. The main thrust was to establish the origin and chemistry of the Western Springs hyper alkaline groundwaters (Na/K enriched Ca(OH){sub 2} type) and to study their interaction with rocks of different compositions, as natural analogues to key processes that might occur at an early stage within the `alkali disturbed zone` of cementitious repositories in different host rocks. Whilst earlier studies at Maqarin were very much site-specific and process-oriented, Phase III provided a regional perspective to the geological evolution of the Maqarin region. This was made possible by greater field access which allowed a more systematic structural and geomorphological study of the area. This has resulted in a greater understanding of the age and spatial relationships concerning formation of the cement zones through spontaneous combustion of the Bituminous Marls, and the subsequent formation of high pH groundwaters at the Eastern and Western Springs locations. At the Western Springs locality, hydrochemical and hydrogeological evaluation of new and published data (plus access to unpublished data), together with detailed mineralogical and geochemical studies, helped to clarify the very earliest stage of cement leachate/host rock interaction. The data were used also to test coupled flow/transport codes developed to assess the long-term evolution of a cementitious repository. Additional objectives addressed include: a) rock matrix diffusion, b) the occurrence and chemical controls on zeolite composition, e) the occurrence and chemical controls on clay stability, and d) the role of microbes, organics and colloids in trace element transport. The Maqarin site now provides a consistent picture explaining the origin of the hyperalkaline groundwaters, and is therefore a unique location for the examination of the mechanisms and processes associated with cementitious repositories. Application of these

  15. Natural analogues of nuclear waste glass corrosion

    International Nuclear Information System (INIS)

    Abrajano, T.A. Jr.; Ebert, W.L.; Luo, J.S.

    1999-01-01

    This report reviews and summarizes studies performed to characterize the products and processes involved in the corrosion of natural glasses. Studies are also reviewed and evaluated on how well the corrosion of natural glasses in natural environments serves as an analogue for the corrosion of high-level radioactive waste glasses in an engineered geologic disposal system. A wide range of natural and experimental corrosion studies has been performed on three major groups of natural glasses: tektite, obsidian, and basalt. Studies of the corrosion of natural glass attempt to characterize both the nature of alteration products and the reaction kinetics. Information available on natural glass was then compared to corresponding information on the corrosion of nuclear waste glasses, specifically to resolve two key questions: (1) whether one or more natural glasses behave similarly to nuclear waste glasses in laboratory tests, and (2) how these similarities can be used to support projections of the long-term corrosion of nuclear waste glasses. The corrosion behavior of basaltic glasses was most similar to that of nuclear waste glasses, but the corrosion of tektite and obsidian glasses involves certain processes that also occur during the corrosion of nuclear waste glasses. The reactions and processes that control basalt glass dissolution are similar to those that are important in nuclear waste glass dissolution. The key reaction of the overall corrosion mechanism is network hydrolysis, which eventually breaks down the glass network structure that remains after the initial ion-exchange and diffusion processes. This review also highlights some unresolved issues related to the application of an analogue approach to predicting long-term behavior of nuclear waste glass corrosion, such as discrepancies between experimental and field-based estimates of kinetic parameters for basaltic glasses

  16. Natural analogues of nuclear waste glass corrosion.

    Energy Technology Data Exchange (ETDEWEB)

    Abrajano, T.A. Jr.; Ebert, W.L.; Luo, J.S.

    1999-01-06

    This report reviews and summarizes studies performed to characterize the products and processes involved in the corrosion of natural glasses. Studies are also reviewed and evaluated on how well the corrosion of natural glasses in natural environments serves as an analogue for the corrosion of high-level radioactive waste glasses in an engineered geologic disposal system. A wide range of natural and experimental corrosion studies has been performed on three major groups of natural glasses: tektite, obsidian, and basalt. Studies of the corrosion of natural glass attempt to characterize both the nature of alteration products and the reaction kinetics. Information available on natural glass was then compared to corresponding information on the corrosion of nuclear waste glasses, specifically to resolve two key questions: (1) whether one or more natural glasses behave similarly to nuclear waste glasses in laboratory tests, and (2) how these similarities can be used to support projections of the long-term corrosion of nuclear waste glasses. The corrosion behavior of basaltic glasses was most similar to that of nuclear waste glasses, but the corrosion of tektite and obsidian glasses involves certain processes that also occur during the corrosion of nuclear waste glasses. The reactions and processes that control basalt glass dissolution are similar to those that are important in nuclear waste glass dissolution. The key reaction of the overall corrosion mechanism is network hydrolysis, which eventually breaks down the glass network structure that remains after the initial ion-exchange and diffusion processes. This review also highlights some unresolved issues related to the application of an analogue approach to predicting long-term behavior of nuclear waste glass corrosion, such as discrepancies between experimental and field-based estimates of kinetic parameters for basaltic glasses.

  17. MAQARIN natural analogue study: phase III

    Energy Technology Data Exchange (ETDEWEB)

    Alexander, W.R.; Mazurek, M.; Waber, H.N. [Univ. of Berne (Switzerland). Institutes of Geology, Mineralogy and Petrology, Rock-Water Interaction Group (GGWW); Arlinger, J.; Erlandson, A.C.; Hallbeck, L.; Pedersen, K. [Goeteborg Univ. (Sweden). Dept. of General and Marine Microbiology; Boehlmann, W.; Fritz, P.; Geyer, S.; Geyer, W.; Hanschman, G.; Kopinke, F.D.; Poerschmann, J. [Umweltforschungszentrum Leipzig-Halle (Germany); Chambers, A.V.; Haworth, A.; Ilett, D.; Linklater, C.M.; Tweed, C.J. [AEA Technology plc, Harwell (United Kingdom); Chenery, S.R.N.; Kemp, S.J.; Milodowski, A.E.; Pearce, J.M.; Reeder, S.; Rochelle, C.A.; Smith, B.; Wetton, P.D.; Wragg, J. [British Geological Survey, Keyworth (United Kingdom); Clark, I.D. [Univ. of Ottawa (Canada). Dept. of Geology; Hodginson, E.; Hughes, C.R. [Univ. of Manchester (United Kingdom). Dept. of Earth Sciences; Hyslop, E.K. [British Geological Survey, Edinburgh (United Kingdom); Karlsson, F. [Swedish Nuclear Fuel and Waste Management Co., Stockholm (Sweden); Khoury, H.N.; Salameh, E. [Univ. of Jordan, Amman (Jordan); Lagerblad, B. [Cement Inst., Stockholm (Sweden); Longworth, G. [Univ. of Manchester (United Kingdom). Dept. of Geology; Pitty, A.F. [Private consultant, Norwich (United Kingdom); Savage, D. [QuantiSci Ltd, Melton Mowbray (United Kingdom); Smellie, J.A.T. [ed.] [Conterra AB, Uppsala (Sweden)

    1998-12-01

    This report represents the conclusion to Phase III of the Maqarin Natural Analogue Study. The main thrust was to establish the origin and chemistry of the Western Springs hyper alkaline groundwaters (Na/K enriched Ca(OH){sub 2} type) and to study their interaction with rocks of different compositions, as natural analogues to key processes that might occur at an early stage within the `alkali disturbed zone` of cementitious repositories in different host rocks. Whilst earlier studies at Maqarin were very much site-specific and process-oriented, Phase III provided a regional perspective to the geological evolution of the Maqarin region. This was made possible by greater field access which allowed a more systematic structural and geomorphological study of the area. This has resulted in a greater understanding of the age and spatial relationships concerning formation of the cement zones through spontaneous combustion of the Bituminous Marls, and the subsequent formation of high pH groundwaters at the Eastern and Western Springs locations. At the Western Springs locality, hydrochemical and hydrogeological evaluation of new and published data (plus access to unpublished data), together with detailed mineralogical and geochemical studies, helped to clarify the very earliest stage of cement leachate/host rock interaction. The data were used also to test coupled flow/transport codes developed to assess the long-term evolution of a cementitious repository. Additional objectives addressed include: a) rock matrix diffusion, b) the occurrence and chemical controls on zeolite composition, e) the occurrence and chemical controls on clay stability, and d) the role of microbes, organics and colloids in trace element transport. The Maqarin site now provides a consistent picture explaining the origin of the hyperalkaline groundwaters, and is therefore a unique location for the examination of the mechanisms and processes associated with cementitious repositories. Application of these

  18. Magnetic properties of Proxima Centauri b analogues

    Science.gov (United States)

    Zuluaga, Jorge I.; Bustamante, Sebastian

    2018-03-01

    The discovery of a planet around the closest star to our Sun, Proxima Centauri, represents a quantum leap in the testability of exoplanetary models. Unlike any other discovered exoplanet, models of Proxima b could be contrasted against near future telescopic observations and far future in-situ measurements. In this paper we aim at predicting the planetary radius and the magnetic properties (dynamo lifetime and magnetic dipole moment) of Proxima b analogues (solid planets with masses of ∼ 1 - 3M⊕ , rotation periods of several days and habitable conditions). For this purpose we build a grid of planetary models with a wide range of compositions and masses. For each point in the grid we run the planetary evolution model developed in Zuluaga et al. (2013). Our model assumes small orbital eccentricity, negligible tidal heating and earth-like radiogenic mantle elements abundances. We devise a statistical methodology to estimate the posterior distribution of the desired planetary properties assuming simple lprior distributions for the orbital inclination and bulk composition. Our model predicts that Proxima b would have a mass 1.3 ≤Mp ≤ 2.3M⊕ and a radius Rp =1.4-0.2+0.3R⊕ . In our simulations, most Proxima b analogues develop intrinsic dynamos that last for ≥4 Gyr (the estimated age of the host star). If alive, the dynamo of Proxima b have a dipole moment ℳdip >0.32÷2.9×2.3ℳdip , ⊕ . These results are not restricted to Proxima b but they also apply to earth-like planets having similar observed properties.

  19. MAQARIN natural analogue study: phase III

    International Nuclear Information System (INIS)

    Alexander, W.R.; Mazurek, M.; Waber, H.N.; Arlinger, J.; Erlandson, A.C.; Hallbeck, L.; Pedersen, K.; Chambers, A.V.; Haworth, A.; Ilett, D.; Linklater, C.M.; Tweed, C.J.; Chenery, S.R.N.; Kemp, S.J.; Milodowski, A.E.; Pearce, J.M.; Reeder, S.; Rochelle, C.A.; Smith, B.; Wetton, P.D.; Wragg, J.; Clark, I.D.; Karlsson, F.; Khoury, H.N.; Salameh, E.; Lagerblad, B.; Longworth, G.; Savage, D.; Smellie, J.A.T.

    1998-12-01

    This report represents the conclusion to Phase III of the Maqarin Natural Analogue Study. The main thrust was to establish the origin and chemistry of the Western Springs hyper alkaline groundwaters (Na/K enriched Ca(OH) 2 type) and to study their interaction with rocks of different compositions, as natural analogues to key processes that might occur at an early stage within the 'alkali disturbed zone' of cementitious repositories in different host rocks. Whilst earlier studies at Maqarin were very much site-specific and process-oriented, Phase III provided a regional perspective to the geological evolution of the Maqarin region. This was made possible by greater field access which allowed a more systematic structural and geomorphological study of the area. This has resulted in a greater understanding of the age and spatial relationships concerning formation of the cement zones through spontaneous combustion of the Bituminous Marls, and the subsequent formation of high pH groundwaters at the Eastern and Western Springs locations. At the Western Springs locality, hydrochemical and hydrogeological evaluation of new and published data (plus access to unpublished data), together with detailed mineralogical and geochemical studies, helped to clarify the very earliest stage of cement leachate/host rock interaction. The data were used also to test coupled flow/transport codes developed to assess the long-term evolution of a cementitious repository. Additional objectives addressed include: a) rock matrix diffusion, b) the occurrence and chemical controls on zeolite composition, e) the occurrence and chemical controls on clay stability, and d) the role of microbes, organics and colloids in trace element transport. The Maqarin site now provides a consistent picture explaining the origin of the hyperalkaline groundwaters, and is therefore a unique location for the examination of the mechanisms and processes associated with cementitious repositories. Application of these

  20. Administrateur de programme, Application des connaissances ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Supervision. Supervision directe : Consultants et personnel temporaire, au besoin. Supervision indirecte : Consultants chargés de préparer des sommaires des résultats de recherche et des communications internes, et personnel temporaire au besoin.

  1. Projektmanagement in Zeiten des Wandels

    OpenAIRE

    Papesch, Gerti

    2003-01-01

    Projektmanagement in Zeiten des Wandels : 2. Fachtagung Projektmanagement, 1. Oktober 2003 / ZWW, Zentrum für Weiterbildung und Wissenstransfer. Gerhard Wilhems ... - Augsburg : ZWW, 2003. - VI, 190 S.

  2. Analogue Hawking radiation from astrophysical black-hole accretion

    International Nuclear Information System (INIS)

    Das, Tapas K

    2004-01-01

    We show that spherical accretion onto astrophysical black holes can be considered as a natural example of an analogue system. We provide, for the first time, an exact analytical scheme for calculating the analogue Hawking temperature and surface gravity for general relativistic accretion onto astrophysical black holes. Our calculation may bridge the gap between the theory of transonic astrophysical accretion and the theory of analogue Hawking radiation. We show that the domination of the analogue Hawking temperature over the actual Hawking temperature may be a real astrophysical phenomenon, though observational tests of this fact will at best be difficult and at worst might prove to be impossible. We also discuss the possibilities of the emergence of analogue white holes around astrophysical black holes. Our calculation is general enough to accommodate accreting black holes with any mass

  3. Analogue to Digital and Digital to Analogue (AD/DA) Conversion Techniques: An Overview

    CERN Multimedia

    CERN. Geneva

    2002-01-01

    The basic ideas behind modern Analogue to Digital and Digital to Analogue (AD/DA) conversion methods will be introduced: a general view of the importance of these devices will be given, along with the digital representation of time-varying, real-world analogue signals. Some CERN applications will be outlined. The variety of conversion methods, their limitations, error sources and measurement methods will form the major part of this presentation. A review of the technological progress in this field over the last 30 years will be presented, concluding with the present 'state of the art' and a quick look at what is just around the corner. This Technical Training Seminar is in the framework of the FEED-2002 Lecture Series, and it is a prerequisite to attending to any of the FEED-2002 Terms. FEED-2002 is a two-term course that will review the techniques dealing with closed loop systems, focussing on time-invariant linear systems. (free attendance, no registration required) More information on the FEED-2002 ...

  4. Analogues of uracil nucleosides with intrinsic fluorescence (NIF-analogues): synthesis and photophysical properties.

    Science.gov (United States)

    Segal, Meirav; Fischer, Bilha

    2012-02-28

    Uridine cannot be utilized as fluorescent probe due to its extremely low quantum yield. For improving the uracil fluorescence characteristics we extended the natural chromophore at the C5 position by coupling substituted aromatic rings directly or via an alkenyl or alkynyl linker to create fluorophores. Extension of the uracil base was achieved by treating 5-I-uridine with the appropriate boronic acid under the Suzuki coupling conditions. Analogues containing an alkynyl linker were obtained from 5-I-uridine and the suitable boronic acid in a Sonogashira coupling reaction. The uracil fluorescent analogues proposed here were designed to satisfy the following requirements: a minimal chemical modification at a position not involved in base-pairing, resulting in relatively long absorption and emission wavelengths and high quantum yield. 5-((4-Methoxy-phenyl)-trans-vinyl)-2'-deoxy-uridine, 6b, was found to be a promising fluorescent probe. Probe 6b exhibits a quantum yield that is 3000-fold larger than that of the natural chromophore (Φ 0.12), maximum emission (478 nm) which is 170 nm red shifted as compared to uridine, and a Stokes shift of 143 nm. In addition, since probe 6b adopts the anti conformation and S sugar puckering favored by B-DNA, it makes a promising nucleoside analogue to be incorporated in an oligonucleotide probe for detection of genetic material.

  5. Meconnaissance des traumatismes des voies urinaires dans un ...

    African Journals Online (AJOL)

    Meconnaissance des traumatismes des voies urinaires dans un contexte de poly traumatisme: a propos de deux observations. ... They insist on good clinical assessment of abdominal trauma doubled the achievement of imaging tests to not overlook lesions of the urinary tract that can put patient's life threatening. Keywords: ...

  6. Composition chimique et effet Acaricide des huiles essentielles des ...

    African Journals Online (AJOL)

    La composition chimique et l\\'effet acaricide des huiles essentielles des feuilles de Chenopodium ambrosioides et Eucalyptus saligna vis-à-vis de Rhipicephalus lunulatus ont été évalués au Laboratoire de Chimie Appliquée et Environnementale de l\\'Université de Dschang dans l\\'Ouest du Cameroun. Cinq doses de ...

  7. Culture du bambou : diversification des moyens de subsistance des ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Culture du bambou : diversification des moyens de subsistance des petits producteurs de tabac du sud de la province de Nyanza, au Kenya - phase II. Au cours de la première phase du projet (projet no 103765), les chercheurs ont effectué une analyse de marché pour le bambou et les produits du bambou, comparé les ...

  8. Diversification des moyens de subsistance des petits producteurs de ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    L'économie du Malawi repose essentiellement sur la culture du tabac, qui représente plus de 70 % des revenus d'exportation. Pour 60 % des 100 000 membres de la National Smallholder Farmers' Association of Malawi (NASFAM), le tabac est la seule et unique source de revenus. Les cultivateurs de tabac, au Malawi ...

  9. Etude des interactions entre les differents acteurs des interventions ...

    African Journals Online (AJOL)

    Etude des interactions entre les differents acteurs des interventions sous directives communautaires et changements obtenus au Benin et au Togo. P.V. Malou Adom, Ch. P. Makoutode, T Gnaro, A.R. Ouro-Koura, E.M. Ouendo, G Napo-Koura, M Makoutode ...

  10. Effets des biomasses vertes de Tithonia diversifolia et des engrais ...

    African Journals Online (AJOL)

    Innovation (MINRESI) pour avoir financé l'intégralité des activités relatives à cette étude. RESUME. L'amélioration de la productivité des sols ferralitiques en zone forestière peut être possible grâce aux intrants locaux en complément à la fertilisation ...

  11. Gestion des ressources naturelles : des solutions avantageuses à ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    environnement et l'accès aux ressources naturelles est un enjeu crucial. Ces 40 dernières années, des chercheurs appuyés par le CRDI ont trouvé des moyens novateurs de réduire la pauvreté tout en protégeant les ressources naturelles dont ...

  12. La recherche en action : des solutions locales, des effets durables ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    15 déc. 2010 ... Le Centre de recherches pour le développement international (CRDI) appuie la production et l'application de connaissances qui améliorent de façon notable la situation des habitants des pays en développement.

  13. Roles et taches des accompagnateurs des patients hospitalises ...

    African Journals Online (AJOL)

    Roles et taches des accompagnateurs des patients hospitalises dans le service de pneumo-phtysiologie au Centre Hospitalier Universitaire Yalgado Ouedraogo de ... Logistical support represented by material support, drug supply, cleaning of premises, and littering occupied respectively 100%, 91%, 42% and 73%.

  14. La diffraction des neutrons et des rayons X pour l'étude structurale des liquides et des verres

    Science.gov (United States)

    Fischer, H. E.; Salmon, P. S.; Barnes, A. C.

    2003-02-01

    La compréhension de mainte propriété physique d'un verre ou d'un liquide nécessite la connaissance des facteurs de structure partiels (PSFs) qui décrivent chacun la distribution d'une espèce atomique autour d'une autre. La technique de diffraction des neutrons avec substitution isotopique (NDIS) [1,2,3], ayant bien réussi a déterminer les PSFs de certains composés [4,5], est pourtant restreinte aux isotopes présentant un contraste suffisant en longueur de diffusion. D'un autre cote, la technique de diffusion anomale des rayons X (AXS ou AXD) [6] permet de faire varier la longueur de diffusion d'une espèce atomique pourvu que son énergie d'absorption soit à la fois accessible et suffisamment élevée pour donner un assez grand transfert du moment. La combinaison des techniques de diffraction des neutrons (avec ou sans substitution isotopique) et de diffraction des rayons X (avec ou sans diffusion anomale) peut donc permettre d'obtenir un meilleur contraste en longueurs de diffusion pour un système donné, mais exige une analyse de données plus soignée pour pouvoir bien tenir compte des erreurs systématiques qui sont différentes pour les 2 techniques [7]. Pour les atomes ayant des distributions électroniques quasi-sphériques, e.g. dans le cas d'un alliage liquide, la combinaison des techniques de NDIS et de diffraction des rayons X s'est déjà montrée très avantageuse pour la détermination des PSFs [8,9]. Dans le cas des verres ayant d'importantes liaisons covalentes, l'effective combinaison des 2 techniques peut être moins directe mais facilitée lorsqu'il s'agit des atomes de grand Z [10,11]. Nous présentons ici un sommaire du méthode et quelques exemples des résultats.

  15. The Greenland Analogue Project. Yearly Report 2009

    International Nuclear Information System (INIS)

    2010-12-01

    A deep geological repository for spent nuclear fuel needs to be designed to keep used nuclear fuel isolated from mankind and the environment for a million years. Within this time frame glacial conditions are expected in regions that have been glaciated in the past two to ten million years. Climate induced changes such as the growth of ice sheets and permafrost will influence and alter the ground surface and subsurface environment, including its hydrology, which may impact repository safety. Glaciation impact assessments have to-date used over-simplified models and conservative assumptions, for example in the representation of ice sheet hydrology, that do not reflect the complexity of natural systems and processes. This is largely due to lack of direct observations of such processes from existing ice sheets, which if more readily available could help reduce uncertainties and provide a strong scientific basis for the treatment of glacial impacts in safety assessments. Our current understanding of the hydrological, hydrogeological and hydrogeochemical processes associated with glacial cycles and their impact on the long-term performance of deep geological repositories for spent nuclear fuel will be significantly improved by studying a modern analogue. To advance the understanding of processes associated with glaciation and their impact on the long-term performance of a deep geological repository, the Greenland Analogue Project (GAP), a four-year field and modelling study of the Greenland ice sheet and sub-surface conditions, has been initiated collaboratively by SKB, Posiva and NWMO. The study site encompasses a land terminus portion of the Greenland ice sheet east of Kangerlussuaq and is in many ways considered to be an appropriate analogue of the conditions that are expected to prevail in much of Canada and Fennoscandia during future glacial cycles. The project is planned to run from 2009 until 2012. The GAP will conduct the first in situ investigations of some of

  16. The Greenland Analogue Project. Yearly Report 2009

    Energy Technology Data Exchange (ETDEWEB)

    2010-12-15

    A deep geological repository for spent nuclear fuel needs to be designed to keep used nuclear fuel isolated from mankind and the environment for a million years. Within this time frame glacial conditions are expected in regions that have been glaciated in the past two to ten million years. Climate induced changes such as the growth of ice sheets and permafrost will influence and alter the ground surface and subsurface environment, including its hydrology, which may impact repository safety. Glaciation impact assessments have to-date used over-simplified models and conservative assumptions, for example in the representation of ice sheet hydrology, that do not reflect the complexity of natural systems and processes. This is largely due to lack of direct observations of such processes from existing ice sheets, which if more readily available could help reduce uncertainties and provide a strong scientific basis for the treatment of glacial impacts in safety assessments. Our current understanding of the hydrological, hydrogeological and hydrogeochemical processes associated with glacial cycles and their impact on the long-term performance of deep geological repositories for spent nuclear fuel will be significantly improved by studying a modern analogue. To advance the understanding of processes associated with glaciation and their impact on the long-term performance of a deep geological repository, the Greenland Analogue Project (GAP), a four-year field and modelling study of the Greenland ice sheet and sub-surface conditions, has been initiated collaboratively by SKB, Posiva and NWMO. The study site encompasses a land terminus portion of the Greenland ice sheet east of Kangerlussuaq and is in many ways considered to be an appropriate analogue of the conditions that are expected to prevail in much of Canada and Fennoscandia during future glacial cycles. The project is planned to run from 2009 until 2012. The GAP will conduct the first in situ investigations of some of

  17. La cogestion des Ressources naturelles

    International Development Research Centre (IDRC) Digital Library (Canada)

    Comprend des réf. bibliogr. ISBN 1-55250-329-1. 1. Cogestion des ressources naturelles—Pays en voie de développement—Cas, Études de. 2. Conservation ...... De fait, les villageois en imputaient la faute aux fonctionnaires nationaux et locaux qui n'avaient pas su mettre efficacement en oeuvre les politiques forestières.

  18. Direction des Publications

    African Journals Online (AJOL)

    Synthese

    diabète et le tabagisme sont des facteurs de risque reconnus [2-4]. Les données épidémiologiques recueillies au cours de ces trente dernières années laissent ... réduction d‟expression du gène LOX-1 et de la libération de TNFα stimulée par les. LDL-oxydées [22]. Chez l‟homme, in vivo, Voutilainen et al. [23] ont mis en ...

  19. COMPLICATIONS CHIRURGICALES DES AVORTEMENTS ...

    African Journals Online (AJOL)

    1 janv. 2004 ... liquide purulent, sérosanguinolent, ou fécaloïde. Les lésions retrouvées étaient classées en lésions utérines et annexielles (Tableau I), lésions ... femmes par an dans le Monde d'après l'Organisation. Mondiale de la Santé [15]. Leur fréquence élevée dans notre série impose une prise systématique des ...

  20. Direction des Publications

    African Journals Online (AJOL)

    Synthese

    Revue Synthèse N° 22, Décembre 2010. N. Benrachou et al. 19. Tableau 3. Composition en triglycérides des trois huiles d'olive). Blanquette. Limli. Bouricha. Variétés. Triglycérides. N° pic. NCE. 3,24 ± 0,01. 2,86± 0,02. 1,06 ± 0,03. LLL. 1. 42. 2,97 ± 0,01. 2,15 ± 0,07. 1,71 ± 0,06. OLLn +PoLL. 2. 0,21 ± 0,01. 0,66 ± 0,02.

  1. Liste des auteurs

    OpenAIRE

    2016-01-01

    Garry Apgar The Voltair Society of America, New York Jean Balcou Université de Bretagne occidentale, Brest Annie Becq Université de Caen Paul Benhamou. Purdue University, West Lafayette, Indiana Reed Benhamou Indiana University, Bloomington, Indiana Jacqueline Biard-Millerioux Université de Poitiers Françoise Bléchet Bibliothèque nationale de France, département des manuscrits, Paris Nicolas Brucker Université de Metz Else-Marie Bukdahl The Royal Danish Academy of Fine Art, Copenhague Christo...

  2. Gestion des ressources naturelles

    International Development Research Centre (IDRC) Digital Library (Canada)

    Mais la situation évolue grâce aux travaux du Réseau international sur le bam- bou et le rotin (INBAR), créé par le CRDI dans les années 1990. À Allahabad, en Inde, la culture du bam- bou a permis de rétablir la fertilité des sols dégradés par l'extraction de l'argile nécessaire à la fabrication de briques, et les agriculteurs.

  3. UK Natural Analogue Coordinating Group: fourth annual report

    International Nuclear Information System (INIS)

    Read, D.; Hooker, P.J.

    1992-01-01

    HMIP has a research programme investigating some naturally radioactive sites as geochemical analogues of radionuclide migration. All of the analogue sites under investigation, both in the U.K. and overseas, are located where elevated uranium concentrations occur naturally. Coordination of the programme is achieved through the UK Natural Analogue Co-ordinating Group (NACG) which has met three times in this reporting period. The NACG is steered by the British Geological Survey. Its purpose is to ensure that the different research projects have an integrated function aimed at increasing our understanding of natural geochemical processes. Effort is also being expended in testing research models which may be used in such assessments. (author)

  4. A chemoselective and continuous synthesis of m-sulfamoylbenzamide analogues

    Directory of Open Access Journals (Sweden)

    Arno Verlee

    2017-02-01

    Full Text Available For the synthesis of m-sulfamoylbenzamide analogues, small molecules which are known for their bioactivity, a chemoselective procedure has been developed starting from m-(chlorosulfonylbenzoyl chloride. Although a chemoselective process in batch was already reported, a continuous-flow process reveals an increased selectivity at higher temperatures and without catalysts. In total, 15 analogues were synthesized, using similar conditions, with yields ranging between 65 and 99%. This is the first automated and chemoselective synthesis of m-sulfamoylbenzamide analogues.

  5. A Low-cost Multi-channel Analogue Signal Generator

    CERN Document Server

    Müller, F; The ATLAS collaboration; Shen, W; Stamen, R

    2009-01-01

    A scalable multi-channel analogue signal generator is presented. It uses a commercial low-cost graphics card with multiple outputs in a standard PC as signal source. Each color signal serves as independent channel to generate an analogue signal. A custom-built external PCB was developed to adjust the graphics card output voltage levels for a specific task, which needed differential signals. The system furthermore comprises a software package to program the signal shape. The signal generator was successfully used as independent test bed for the ATLAS Level-1 Trigger Pre-Processor, providing up to 16 analogue signals.

  6. Utilisation sans risque des eaux usées, des excréta et des eaux ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Les responsables de ce projet piloteront l'application et l'adaptation des principes directeurs relatifs à l'utilisation sans risque des eaux usées, des excreta et des eaux grises en agriculture et en aquaculture (Guidelines for the Safe Use of Wastewater, Excreta and Greywater in Agriculture and Aquaculture), que ...

  7. Long-term predictions using natural analogues

    International Nuclear Information System (INIS)

    Ewing, R.C.

    1995-01-01

    One of the unique and scientifically most challenging aspects of nuclear waste isolation is the extrapolation of short-term laboratory data (hours to years) to the long time periods (10 3 -10 5 years) required by regulatory agencies for performance assessment. The direct validation of these extrapolations is not possible, but methods must be developed to demonstrate compliance with government regulations and to satisfy the lay public that there is a demonstrable and reasonable basis for accepting the long-term extrapolations. Natural systems (e.g., open-quotes natural analoguesclose quotes) provide perhaps the only means of partial open-quotes validation,close quotes as well as data that may be used directly in the models that are used in the extrapolation. Natural systems provide data on very large spatial (nm to km) and temporal (10 3 -10 8 years) scales and in highly complex terranes in which unknown synergisms may affect radionuclide migration. This paper reviews the application (and most importantly, the limitations) of data from natural analogue systems to the open-quotes validationclose quotes of performance assessments

  8. Chirurgie des grassmanniennes

    CERN Document Server

    Lafforgue, Laurent

    2003-01-01

    Les compactifications diverses de variétés de modules sont un thème important et récurrent des mathématiques modernes, et elles connaissent un grand nombre d'applications. Ce livre traite le cas de cellules de Schubert minces, qui sont de sous-variétés naturelles de grassmanniennes. L'auteur a été amené à traiter ces questions par un cas particulier lié à ses travaux sur le programme de Langlands. Dans cette monographie, il en développe une théorie plus systématique, présentant le fortes similarités avec celle des modules du courbes stables. The various compactifications of moduli spaces are an important recurrent theme of modern mathematics, and they have a large number of applications. This book treats the case of thin Schubert varieties, which are natural subvarieties of Grassmannians. The author was led to these questions by a particular case linked to his work on the Langlands program. In this monograph, he develops the theory in a more systematic way, which exhibits strong similarities...

  9. Mécanique des sols et des roches

    CERN Document Server

    Vullier, Laurent; Zhao, Jian

    2016-01-01

    La mécanique des sols et la mécanique des roches sont des disciplines généralement traitées séparément dans la littérature. Pour la première fois, un traité réunit ces deux spécialités, en intégrant également les connaissances en lien avec les écoulements souterrains et les transferts thermiques. A la fois théorique et pratique, cet ouvrage propose tout d'abord une description détaillée de la nature et de la composition des sols et des roches, puis s'attache à la modélisation de problèmes aux conditions limites et présente les essais permettant de caractériser les sols et les roches, tant d'un point de vue mécanique qu'hydraulique et thermique. La problématique des sols non saturés et des écoulements multiphasiques est également abordée. Une attention particulière est portée aux lois de comportement mécanique et à la détermination de leurs paramètres par des essais in situ et en laboratoire, et l'ouvrage offre également une présentation détaillée des systèmes de classi...

  10. Perception des producteurs sur l'utilisation des déjections de ...

    African Journals Online (AJOL)

    Objectif: L'étude vise à analyser la perception des producteurs sur la contribution des chenilles dans la gestion de la fertilité des sols et dans la production des ... Les producteurs enquêtés ont par ailleurs, identifié les facteurs anthropiques, climatiques et édaphiques comme les facteurs pouvant influencer la dynamique des ...

  11. La Flore Des Adventices Des Cultures Cotonnieres De La Region ...

    African Journals Online (AJOL)

    A partir de relevés itinérants réalisés dans des cultures cotonnières de la région du Worodougou, en Côte d\\'Ivoire, précisement à Mankono, Dianra et Séguéla, 230 espèces d\\'adventices ont été recensées. Dans chacune des trois localités inventoriées, il apparaît que les familles des Poaceae, Fabaceae et Asteraceae ...

  12. Evaluation de la gestion des dechets issus des activites de ...

    African Journals Online (AJOL)

    Le moyen d'élimination des déchets utilisé est l'incinération. Tous les agents impliqués dans la vaccination ont une connaissance des risques de contamination liés aux déchets vaccinaux. La gestion des déchets reste un système global dont tous les aspects méritent d'être considérés. Chaque étape de l'élimination est ...

  13. Solistatinol, a novel phenolic compactin analogue from Penicillium solitum

    DEFF Research Database (Denmark)

    Larsen, Thomas Ostenfeld; Lange, Lene; Schnorr, Kirk

    2007-01-01

    Solistatinol, a novel phenolic compactin analogue, has been isolated from Penicillium solitum using a UV-guided strategy. The structure and relative stereochemistry were determined by NMR spectroscopy and mass spectrometry. The absolute stereochemistry was determined by chemical degradation...

  14. Heterocyclic Analogues of Modafinil as Novel, Atypical Dopamine Transporter Inhibitors.

    Science.gov (United States)

    Kalaba, Predrag; Aher, Nilima Y; Ilić, Marija; Dragačević, Vladimir; Wieder, Marcus; Miklosi, Andras G; Zehl, Martin; Wackerlig, Judith; Roller, Alexander; Beryozkina, Tetyana; Radoman, Bojana; Saroja, Sivaprakasam R; Lindner, Wolfgang; Gonzalez, Eduardo Perez; Bakulev, Vasiliy; Leban, Johann Jakob; Sitte, Harald H; Urban, Ernst; Langer, Thierry; Lubec, Gert

    2017-11-22

    Modafinil is a wake promoting compound with high potential for cognitive enhancement. It is targeting the dopamine transporter (DAT) with moderate selectivity, thereby leading to reuptake inhibition and increased dopamine levels in the synaptic cleft. A series of modafinil analogues have been reported so far, but more target-specific analogues remain to be discovered. It was the aim of this study to synthesize and characterize such analogues and, indeed, a series of compounds were showing higher activities on the DAT and a higher selectivity toward DAT versus serotonin and norepinephrine transporters than modafinil. This was achieved by substituting the amide moiety by five- and six-membered aromatic heterocycles. In vitro studies indicated binding to the cocaine pocket on DAT, although molecular dynamics revealed binding different from that of cocaine. Moreover, no release of dopamine was observed, ruling out amphetamine-like effects. The absence of neurotoxicity of a representative analogue may encourage further preclinical studies of the above-mentioned compounds.

  15. Trustworthiness and Influence: A Reexamination in an Extended Counseling Analogue.

    Science.gov (United States)

    Rothmeier, Rosemarie C.; Dixon, David N.

    1980-01-01

    The study demonstrated that: (1) interviewer trustworthiness can be manipulated in an analogue interview setting; and (2) interviewer trustworthiness is related to interpersonal influence in the interview setting. Findings follow a pattern of outcomes predicted by cognitive dissonance theory. (Author)

  16. Synthesis and antifungal activity of two novel spermidine analogues.

    Science.gov (United States)

    Mackintosh, C A; Slater, L A; McClintock, C A; Walters, D R; Havis, N D; Robins, D J

    1997-03-01

    Two spermidine analogues were synthesised and examined for antifungal activity. Both compounds used as 1 mM post-inoculation sprays reduced infection of barley seedlings by the powdery mildew fungus, Erysiphe graminis f.sp. hordei, infection of broad bean seedlings by the rust fungus, Uromyces viciae-fabae, and infection of apple seedlings by the powdery mildew fungus, Podosphaera leucotricha. Since these fungal pathogens cannot be cultured axenically, the effects of the two spermidine analogues on mycelial growth in vitro, as well as preliminary investigations on polyamine biosynthesis, were undertaken using the oat stripe pathogen, Pyrenophora avenae. Although neither compound affected radial growth of the fungus on plates, both analogues reduced fungal biomass in liquid culture substantially. The two spermidine analogues, used at a concentration of 1 mM, had no significant effect on the conversion of labelled ornithine into polyamines in P. avenae.

  17. Current prodrug strategies for improving oral absorption of nucleoside analogues

    Directory of Open Access Journals (Sweden)

    Youxi Zhang

    2014-04-01

    Full Text Available Nucleoside analogues are first line chemotherapy in various severe diseases: AIDS (acquired immunodeficiency disease syndrome, cytomegalovirus infections, cancer, etc. However, many nucleoside analogues exhibit poor oral bioavailability because of their high polarity and low intestinal permeability. In order to get around this drawback, prodrugs have been utilized to improve lipophilicity by chemical modification of the parent drug. Alternatively, prodrugs targeting transporters present in the intestine have been applied to promote the transport of the nucleoside analogues. Valacyclovir and valganciclovir are two classic valine ester prodrugs transported by oligopeptide transporter 1. The ideal prodrug achieves delivery of a parent drug by attaching a non-toxic moiety that is stable during transport, but is readily degraded to the parent drug once at the target. This article presents advances of prodrug approaches for enhancing oral absorption of nucleoside analogues.

  18. Insulin analogues in pregnancy and specific congenital anomalies

    DEFF Research Database (Denmark)

    de Jong, Josta; Garne, Ester; Wender-Ozegowska, Ewa

    2016-01-01

    women with pregestational diabetes using insulin analogues in the first trimester and information on congenital anomalies. The studies were analysed to compare the congenital anomaly rate among foetuses of mothers using insulin analogues with foetuses of mothers using human insulin. Of 29 studies, we...... included 1286 foetuses of mothers using short-acting insulin analogues with 1089 references of mothers using human insulin and 768 foetuses of mothers using long-acting insulin analogues with 685 references of mothers using long-acting human insulin (Neutral Protamine Hagedorn). The congenital anomaly rate...... was 4.84% and 4.29% among the foetuses of mothers using lispro and aspart. For glargine and detemir, the congenital anomaly rate was 2.86% and 3.47%, respectively. No studies on the use of insulin glulisine and degludec in pregnancy were found. There was no statistically significant difference...

  19. Analogue Signal Processing: Collected Papers 1996-97

    DEFF Research Database (Denmark)

    1997-01-01

    This document is a collection of the papers presented at international conferences and in international journals by the analogue signal processing group of the Department of Information Technology, Technical University of Denmark, in 1996 and 1997....

  20. Evaluation des activites antihyperglycemiantes d'extraits aqueux de ...

    African Journals Online (AJOL)

    écorce de Casuarina equisetifolia révèle la présence des alcaloïdes, des tanins, des flavonoïdes, des leucoanthocyanes, des dérivés anthracéniques, des coumarines et des composés réducteurs, composés aux propriétés médicales multiples, ...

  1. 3-alkyl fentanyl analogues: Structure-activity-relationship study

    OpenAIRE

    Vučković, Sonja; Savić-Vujović, Katarina; Srebro, Dragana; Ivanović, Milovan; Došen-Mićović, Ljiljana; Stojanović, Radan; Prostran, Milica

    2012-01-01

    Introduction. Fentanyl belongs to 4-anilidopiperidine class of synthetic opioid analgesics. It is characterized by high potency, rapid onset and short duration of action. A large number of fentanyl analogues have been synthesized so far, both to establish the structure-activity-relationship (SAR) and to find novel, clinically useful analgesic drugs. Objective. In this study, newly synthesized 3-alkyl fentanyl analogues were examined for analgesic activity and compared with fentanyl. Methods. ...

  2. Analogue Signal Processing: Collected Papers 1994-95

    DEFF Research Database (Denmark)

    1996-01-01

    This document is a collection of the papers presented at international conferences and in international journals by the analogue signal processing group of Electronics Institute, Technical University of Denmark, in 1994 and 1995.......This document is a collection of the papers presented at international conferences and in international journals by the analogue signal processing group of Electronics Institute, Technical University of Denmark, in 1994 and 1995....

  3. The Greenland Analogue Project, Yearly Report 2009

    International Nuclear Information System (INIS)

    2011-08-01

    To advance the understanding of processes associated with glaciation and their impact on the long-term performance of a deep geological repository, the Greenland Analogue Project (GAP), a four-year field and modelling study of the Greenland ice sheet and sub-surface conditions, has been initiated collaboratively by SKB, Posiva and NWMO. The study site encompasses a land terminus portion of the Greenland ice sheet east of Kangerlussuaq and is in many ways considered to be an appropriate analogue of the conditions that are expected to prevail in much of Canada and Fennoscandia during future glacial cycles. The project is planned to run from 2009 until 2012. The GAP will conduct the first in situ investigations of some of the parameters and processes needed to achieve a realistic understanding of how an ice sheet may impact a deep repository, and will provide measurements, observations and data that may significantly improve our safety assessments and risk analyses of glaciation scenarios. The project includes three sub-projects (A-C) with specific individual objectives, which collectively aim at contributing knowledge and input to the overall project aim. Three field campaigns were carried out in SPA during 2009. These campaigns focused on: (1) deployment and maintenance of AWS and GPS stations and to test the deep-look radar equipment; (2) investigating the hydrological processes and feedbacks and testing of passive seismic equipment; (3) downloading of weather station data and GPS data and winterizing the equipment. An extensive archive of real-time satellite remote sensing datasets has been obtained to be able to better constraint the surface elevation and dynamics of basal hydrological mechanisms. From this archive it has been possible to obtain Russell Glacier Cachment (RGC)-wide constraints on annual, seasonal and specific temporal snapshots of surface speed, initial lake and moulin distribution, drainage and network connections along with the temporal

  4. Habitability & Astrobiology Research in Mars Terrestrial Analogues

    Science.gov (United States)

    Foing, Bernard

    2014-05-01

    We performed a series of field research campaigns (ILEWG EuroMoonMars) in the extreme Utah desert relevant to Mars environments, and in order to help in the interpretation of Mars missions measurements from orbit (MEX, MRO) or from the surface (MER, MSL), or Moon geochemistry (SMART-1, LRO). We shall give an update on the sample analysis in the context of habitability and astrobiology. Methods & Results: In the frame of ILEWG EuroMoonMars campaigns (2009 to 2013) we deployed at Mars Desert Research station, near Hanksville Utah, a suite of instruments and techniques [A, 1, 2, 9-11] including sample collection, context imaging from remote to local and microscale, drilling, spectrometers and life sensors. We analyzed how geological and geochemical evolution affected local parameters (mineralogy, organics content, environment variations) and the habitability and signature of organics and biota. Among the important findings are the diversity in the composition of soil samples even when collected in close proximity, the low abundances of detectable PAHs and amino acids and the presence of biota of all three domains of life with significant heterogeneity. An extraordinary variety of putative extremophiles was observed [3,4,9]. A dominant factor seems to be soil porosity and lower clay-sized particle content [6-8]. A protocol was developed for sterile sampling, contamination issues, and the diagnostics of biodiversity via PCR and DGGE analysis in soils and rocks samples [10, 11]. We compare the 2009 campaign results [1-9] to new measurements from 2010-2013 campaigns [10-12] relevant to: comparison between remote sensing and in-situ measurements; the study of minerals; the detection of organics and signs of life. Keywords: field analogue research, astrobiology, habitability, life detection, Earth-Moon-Mars, organics References [A] Foing, Stoker & Ehrenfreund (Editors, 2011) "Astrobiology field Research in Moon/Mars Analogue Environments", Special Issue of International

  5. Application of natural analogues in the Yucca Mountain project - overview

    International Nuclear Information System (INIS)

    Simmons, Ardyth M.

    2003-01-01

    The Natural Analogue Synthesis Report (NASR) [1] provides a compilation of information from analogues that test, corroborate, and add confidence to process models and model predictions pertinent to total system performance assessment (TSPA). The report updated previous work [2] with new literature examples and results of quantitative studies conducted by the Yucca Mountain Project (YMP). The intent of the natural analogue studies was to collect corroborative evidence from analogues to demonstrate greater understanding of processes expected to occur during postclosure of a proposed Yucca Mountain repository. Natural analogues, as used here, refer to either natural or anthropogenic systems in which processes similar to those expected to occur in a nuclear waste repository are thought to have occurred over long time periods (decades to millenia) and large spatial scales (up to tens of kilometers). In the past, the YMP has used analogues for testing and building confidence in conceptual and numerical process models in a number of ways. Yucca Mountain mineral alteration phases provided a self-analogue for postclosure alteration [3]. Thermodynamic parameters for silica minerals of the Wairakai, New Zealand geothermal field were added to databases used in geochemical modeling [4]. Scoping calculations of radionuclide transport using the Yucca Mountain TSPA numerical model were conducted for the Peqa Blanca site [5]. Eruption parameters from the Cerro Negro volcano, Nicaragua, were used to verify codes that model ash plume dispersion [6]. Analogues have also been used in supplemental science and performance analyses to provide multiple lines of evidence in support of both analyses and model reports (AMRs) [7]; in screening arguments for inclusion or exclusion of features, events, and processes (FEP)s in TSPAs; in the quantification of uncertainties [7]; in expert elicitations of volcanic and seismic hazards [8, 9] and in peer reviews [10]. Natural analogues may be applied

  6. Characterisation of insulin analogues therapeutically available to patients

    KAUST Repository

    Adams, Gary G.

    2018-03-29

    The structure and function of clinical dosage insulin and its analogues were assessed. This included \\'native insulins\\' (human recombinant, bovine, porcine), \\'fast-acting analogues\\' (aspart, glulisine, lispro) and \\'slow-acting analogues\\' (glargine, detemir, degludec). Analytical ultracentrifugation, both sedimentation velocity and equilibrium experiments, were employed to yield distributions of both molar mass and sedimentation coefficient of all nine insulins. Size exclusion chromatography, coupled to multi-angle light scattering, was also used to explore the function of these analogues. On ultracentrifugation analysis, the insulins under investigation were found to be in numerous conformational states, however the majority of insulins were present in a primarily hexameric conformation. This was true for all native insulins and two fast-acting analogues. However, glargine was present as a dimer, detemir was a multi-hexameric system, degludec was a dodecamer (di-hexamer) and glulisine was present as a dimer-hexamer-dihexamer system. However, size-exclusion chromatography showed that the two hexameric fast-acting analogues (aspart and lispro) dissociated into monomers and dimers due to the lack of zinc in the mobile phase. This comprehensive study is the first time all nine insulins have been characterised in this way, the first time that insulin detemir have been studied using analytical ultracentrifugation and the first time that insulins aspart and glulisine have been studied using sedimentation equilibrium. The structure and function of these clinically administered insulins is of critical importance and this research adds novel data to an otherwise complex functional physiological protein.

  7. Engagements contractuels et performances des organisations de ...

    African Journals Online (AJOL)

    amélioration des performances des organisations des producteurs (OP) à l'Ouest Cameroun. Il est basé sur des enquêtes par questionnaires auprès des délégués de 33 OP de maïs bénéficiaires de l'encadrement du Programme d'Amélioration de la ...

  8. Médecine des voyages

    Science.gov (United States)

    Aw, Brian; Boraston, Suni; Botten, David; Cherniwchan, Darin; Fazal, Hyder; Kelton, Timothy; Libman, Michael; Saldanha, Colin; Scappatura, Philip; Stowe, Brian

    2014-01-01

    Résumé Objectif Définir la pratique de la médecine des voyages, présenter les éléments fondamentaux d’une consultation complète préalable aux voyages à des voyageurs internationaux et aider à identifier les patients qu’il vaudrait mieux envoyer en consultation auprès de professionnels de la médecine des voyages. Sources des données Les lignes directrices et les recommandations sur la médecine des voyages et les maladies liées aux voyages publiées par les autorités sanitaires nationales et internationales ont fait l’objet d’un examen. Une recension des ouvrages connexes dans MEDLINE et EMBASE a aussi été effectuée. Message principal La médecine des voyages est une spécialité très dynamique qui se concentre sur les soins préventifs avant un voyage. Une évaluation exhaustive du risque pour chaque voyageur est essentielle pour mesurer avec exactitude les risques particuliers au voyageur, à son itinéraire et à sa destination et pour offrir des conseils sur les interventions les plus appropriées en gestion du risque afin de promouvoir la santé et prévenir les problèmes médicaux indésirables durant le voyage. Des vaccins peuvent aussi être nécessaires et doivent être personnalisés en fonction des antécédents d’immunisation du voyageur, de son itinéraire et du temps qu’il reste avant son départ. Conclusion La santé et la sécurité d’un voyageur dépendent du degré d’expertise du médecin qui offre le counseling préalable à son voyage et les vaccins, au besoin. On recommande à ceux qui donnent des conseils aux voyageurs d’être conscients de l’ampleur de cette responsabilité et de demander si possible une consultation auprès de professionnels de la médecine des voyages pour tous les voyageurs à risque élevé.

  9. Influence des facteurs agro-écologiques et des herbicides sur le ...

    African Journals Online (AJOL)

    Influence des facteurs agro-écologiques et des herbicides sur le rendement et les caractéristiques technologiques des grains et farines de blés tendres ( Triticum aestivum L.) et durs ( Triticum durum Desf.)

  10. Evaluation des pratiques de gestion des adventices en riziculture ...

    African Journals Online (AJOL)

    Le riz est l'aliment principal pour la quasi-totalité des populations vivant en Côte d'Ivoire. Cependant, les adventices sont considérées comme la contrainte biologique la plus importante faisant obstacle à la production rizicole. L'objectif de cette étude menée en 2015 était d'évaluer différentes techniques de gestion des ...

  11. Des agriculteurs trouvent des moyens d'exploiter les avantages ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    19 sept. 2013 ... Le tout dernier prototype sera adapté en vue de son utilisation dans les collectivités et les villages. On continuera d'y apporter des améliorations pour lui permettre de moudre d'autres mils (le pied de coq et l'herbe à épée ou kodo). Des chercheurs de la Tamil Nadu Agricultural University s'emploient aussi ...

  12. Modernisation des marchés agroalimentaires - inclusion des petits ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Les marchés agroalimentaires connaissent de rapides changements dans les pays en développement et les pays en transition. Sous l'influence de la libéralisation du commerce et des nouvelles technologies de transformation des aliments et de commerce de détail, les marchés agroalimentaires évoluent vers une plus ...

  13. Therapie des Harnwegsinfekts

    Directory of Open Access Journals (Sweden)

    Stoiser B

    2010-01-01

    Full Text Available Harnwegsinfektionen gehören zu den häufigsten entzündlichen Erkrankungen im niedergelassenen Bereich. Eine intelligente Therapiestrategie stellt damit nicht nur eine klinische Herausforderung dar, sondern ermöglicht rasche Heilung, Vermeidung von Resistenzbildungen sowie oft unnötiger, teurer diagnostischer Schritte. Der erste entscheidende Schritt ist die genaue Klassifizierung des Harnweginfektes – asymptomatische Bakteriurie bis zur komplizierten Pyelonephritis. Hier entscheiden sich bereits Aggressivität der Behandlung sowie diagnostischer Aufwand. Für die Entwicklung einer empirischen antimikrobiellen Therapie ist die Kenntnis der häufigsten Erreger sowie lokaler Resistenzmuster wichtig. Bei gezieltem Vorgehen können die meisten Harnwegsinfekte ohne erhöhten diagnostischen Aufwand therapiert werden.

  14. Code des baux 2018

    CERN Document Server

    Vial-Pedroletti, Béatrice; Kendérian, Fabien; Chavance, Emmanuelle; Coutan-Lapalus, Christelle

    2017-01-01

    Le code des baux 2018 vous offre un contenu extrêmement pratique, fiable et à jour au 1er août 2017. Cette 16e édition intègre notamment : le décret du 27 juillet 2017 relatif à l’évolution de certains loyers dans le cadre d’une nouvelle location ou d’un renouvellement de bail, pris en application de l’article 18 de la loi n° 89-462 du 6 juillet 1989 ; la loi du 27 janvier 2017 relative à l’égalité et à la citoyenneté ; la loi du 9 décembre 2016 relative à la transparence, à la lutte contre la corruption et à la modernisation de la vie économique ; la loi du 18 novembre 2016 de modernisation de la justice du xxie siècle

  15. Prise en compte du gonflement des terrains dans le dimensionnement des revêtements des tunnels

    OpenAIRE

    Bultel, Frédéric

    2001-01-01

    Travail préparé au Laboratoire Central des Ponts et Chaussées (LCPC-Paris) dans le cadre d'une convention CIFRE avec la société Scetauroute,Composition du jury : MM. R. KASTNER professeur à l'Institut National des Sciences Appliquées de Lyon (rapporteur),I. SHAHROUR professeur à l'Ecole Universitaire Des Ingénieurs de Lille (rapporteur), P. EGGER professeur à l'Ecole Polytechnique Fédérale de Lausanne (Examinateur), B. GAUDIN expert géotechnique à Scetauroute-DTTS (Examinateur), J.P. MAGNAN D...

  16. Digitalisierung des Kulturellen Erbes (Europas)

    NARCIS (Netherlands)

    Gruber, Marion

    2011-01-01

    Gruber, M. R. (2011, 13 December). Digitalisierung des Kulturellen Erbes (Europas). Guest lecture at the IPMZ - Institute of Mass Communication and Media Research, Devision Media Change & Innovation, University of Zurich, Switzerland.

  17. La cogestion des Ressources naturelles

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le Liban — les conflits sur les ressources et la modification des moyens de subsistance à Arsaal . 71. Chapitre ..... Ainsi, un seul arbre d'une forêt peut fournir des fruits, du bois de chauffage, du fourrage et de l'ombrage; constituer un stabilisateur du sol et un habitat faunique et représenter un lien avec l'identité ancestrale.

  18. CONTRAINTES INSTITUTIONNELLES ET LABELLISATION DES ...

    African Journals Online (AJOL)

    de labellisation des produits algériens (particulièrement le vin et les dattes) par le biais des indications géographiques et les contraintes institutionnels et territoriales qui contrarient ce processus. Le contexte algérien, très marqué par une économie mono-ex- portatrice et très dépendante à l'égard d'un seul type de produit, ...

  19. Incorporation of tryptophan analogues into the lantibiotic nisin.

    Science.gov (United States)

    Zhou, Liang; Shao, Jinfeng; Li, Qian; van Heel, Auke J; de Vries, Marcel P; Broos, Jaap; Kuipers, Oscar P

    2016-05-01

    Lantibiotics are posttranslationally modified peptides with efficient inhibitory activity against various Gram-positive bacteria. In addition to the original modifications, incorporation of non-canonical amino acids can render new properties and functions to lantibiotics. Nisin is the most studied lantibiotic and contains no tryptophan residues. In this study, a system was constructed to incorporate tryptophan analogues into nisin, which included the modification machinery (NisBTC) and the overexpression of tryptophanyl-tRNA synthetase (TrpRS). Tryptophan and three different tryptophan analogues (5-fluoroTrp (5FW), 5-hydroxyTrp (5HW) and 5-methylTrp (5MeW)) were successfully incorporated at four different positions of nisin (I1W, I4W, M17W and V32W). The incorporation efficiency of tryptophan analogues into mutants I1W, M17W and V32W was over 97 %, while the mutant I4W showed relatively low incorporation efficiency (69-93 %). The variants with 5FW showed relatively higher production yield, while 5MeW-containing variants showed the lowest yield. The dehydration efficiency of serines or threonines was affected by the tryptophan mutants of I4W and V32W. The affinity of the peptides for the cation-ion exchange and reverse phase chromatography columns was significantly reduced when 5HW was incorporated. The antimicrobial activity of IIW and its 5FW analogue both decreased two times compared to that of nisin, while that of its 5HW analogue decreased four times. The 5FW analogue of I4W also showed two times decreased activity than nisin. However, the mutant M17W and its 5HW analogue both showed 32 times reduced activity relative to that of nisin.

  20. Insulin analogues and cancer: a note of caution

    Directory of Open Access Journals (Sweden)

    Joseph A.M.J.L. eJanssen

    2014-05-01

    Full Text Available Abstract In view of the lifelong exposure and large patient populations involved, insulin analogues with an increased mitogenic effect in comparison to human insulin may potentially constitute a major health problem, since these analogues may possibly induce the growth of pre-existing neoplasms. At present, the available data suggest that insulin analogues are safe. In line with these findings, we observed that serum of diabetic patients treated with insulin analogues, compared to that of diabetic patients treated with human insulin, did not induce an increased phosphorylation of tyrosine residues of the insulin-like growth factor-I receptor (IGF-IR. However, the classical model of the IGF-IR signaling may be insufficient to explain (all mitogenic effects of insulin analogues since also non-canonical signaling pathways of the IGF-IR may play a major role in this respect. Although phosphorylation of tyrosine residues of the IGF-IR is generally considered to be the initial activation step within the intracellular IGF-IR signaling pathway, it has been found that cells undergo a signaling switch under hyperglycemic conditions. After this switch, a completely different mechanism is utilized to activate the mitogenic (mitogen-activated protein kinase (MAPK pathways of the IGF-IR that is independent from tyrosine phosphorylation of the IGF-IR. At present it is unknown whether activation of this alternative intracellular pathway of the IGF-IR occurs during hyperglycemia in vivo and whether it is stronger in patients treated with (some insulin analogues than in patients treated with human insulin. In addition, it is unknown whether the insulin receptors (IRs also undergo a signaling switch during hyperglycemia. This should be investigated in future studies. Finally, relative overexpression of IR isoform A (IR-A in (pre cancer tissues may play a key role in the development and progression of human cancers during treatment with insulin (analogues. Further

  1. MARKOV GRAPHS OF ONE–DIMENSIONAL DYNAMICAL SYSTEMS AND THEIR DISCRETE ANALOGUES AND THEIR DISCRETE ANALOGUES

    Directory of Open Access Journals (Sweden)

    SERGIY KOZERENKO

    2016-04-01

    Full Text Available One feature of the famous Sharkovsky’s theorem is that it can be proved using digraphs of a special type (the so–called Markov graphs. The most general definition assigns a Markov graph to every continuous map from the topological graph to itself. We show that this definition is too broad, i.e. every finite digraph can be viewed as a Markov graph of some one–dimensional dynamical system on a tree. We therefore consider discrete analogues of Markov graphs for vertex maps on combinatorial trees and characterize all maps on trees whose discrete Markov graphs are of the following types: complete, complete bipartite, the disjoint union of cycles, with every arc being a loop.

  2. Mitigation of Ship Electro-Optical Susceptibility Against Conventional and Asymmetric Threats (Attenuation de la vulnerabilite electro-optique des navires contre les menaces conventionnelles et asymetriques)

    Science.gov (United States)

    2014-04-01

    conclu que le système de gestion de signature réduisait non seulement la signature, mais réduirait également la portée d’acquisition d’objectif des...doivent comporter la dénomination « STO », « RTO » ou « AGARD » selon le cas, suivi du numéro de série. Des informations analogues, telles que le titre...ETATS-UNIS ARGE ve Teknoloji Dairesi Defense Technical Information Center PORTUGAL Başkanlığı 8725 John J. Kingman Road Estado Maior da Força

  3. Non-analogue Monte Carlo method, application to neutron simulation; Methode de Monte Carlo non analogue, application a la simulation des neutrons

    Energy Technology Data Exchange (ETDEWEB)

    Morillon, B.

    1996-12-31

    With most of the traditional and contemporary techniques, it is still impossible to solve the transport equation if one takes into account a fully detailed geometry and if one studies precisely the interactions between particles and matters. Only the Monte Carlo method offers such a possibility. However with significant attenuation, the natural simulation remains inefficient: it becomes necessary to use biasing techniques where the solution of the adjoint transport equation is essential. The Monte Carlo code Tripoli has been using such techniques successfully for a long time with different approximate adjoint solutions: these methods require from the user to find out some parameters. If this parameters are not optimal or nearly optimal, the biases simulations may bring about small figures of merit. This paper presents a description of the most important biasing techniques of the Monte Carlo code Tripoli ; then we show how to calculate the importance function for general geometry with multigroup cases. We present a completely automatic biasing technique where the parameters of the biased simulation are deduced from the solution of the adjoint transport equation calculated by collision probabilities. In this study we shall estimate the importance function through collision probabilities method and we shall evaluate its possibilities thanks to a Monte Carlo calculation. We compare different biased simulations with the importance function calculated by collision probabilities for one-group and multigroup problems. We have run simulations with new biasing method for one-group transport problems with isotropic shocks and for multigroup problems with anisotropic shocks. The results show that for the one-group and homogeneous geometry transport problems the method is quite optimal without splitting and russian roulette technique but for the multigroup and heterogeneous X-Y geometry ones the figures of merit are higher if we add splitting and russian roulette technique.

  4. Évaluation des pratiques agricoles des légumes feuilles : le cas des ...

    African Journals Online (AJOL)

    SARAH

    30 sept. 2017 ... sont le barrage, les puits à faible profondeur (1 à 2 m) et les tranchées creusées dans la cuvette par les maraîchers. 22 % des producteurs utilisent l'eau du barrage directement, 60 % l'eau des puits (figure 2) uniquement et 18 % utilisent les deux types de ressources (figure 3). Toutes les cultures en saison ...

  5. Étude des caractéristiques des peuplements et des noix de Cocos ...

    African Journals Online (AJOL)

    Cocos nucifera est l'un des arbres cultivés le plus répandu. Il se propage par graine avec un long cycle biologique. Cette étude qui avait pour objectif de caractériser les populations naturelles de cocotiers des Niayes (Sénégal), notamment leur structure et leur fruit, a montré que les arbres sont âgés et leur régénération ...

  6. L'accumulation des métaux lourds au niveau des cultures : Cas des ...

    African Journals Online (AJOL)

    Le Bassin de Sebou présente une importance socio-économique pour le Maroc. En effet, il est sujet de diverses utilisations ; eau potable, eau d'irrigation et eau industrielle. Toutefois, ce bassin subit des pressions multiples, notamment par la pollution métallique. Considérant le risque de bioaccumulation des métaux par ...

  7. Theoretical study on absorption and emission spectra of adenine analogues.

    Science.gov (United States)

    Liu, Hongxia; Song, Qixia; Yang, Yan; Li, Yan; Wang, Haijun

    2014-04-01

    Fluorescent nucleoside analogues have attracted much attention in studying the structure and dynamics of nucleic acids in recent years. In the present work, we use theoretical calculations to investigate the structural and optical properties of four adenine analogues (termed as A1, A2, A3, and A4), and also consider the effects of aqueous solution and base pairing. The results show that the fluorescent adenine analogues can pair with thymine to form stable H-bonded WC base pairs. The excited geometries of both adenine analogues and WC base pairs are similar to the ground geometries. The absorption and emission maxima of adenine analogues are greatly red shifted compared with nature adenine, the oscillator strengths of A1 and A2 are stronger than A3 and A4 in both absorption and emission spectra. The calculated low-energy peaks in the absorption spectra are in good agreement with the experimental data. In general, the aqueous solution and base pairing can slightly red-shift both the absorption and emission maxima, and can increase the oscillator strengths of absorption spectra, but significantly decrease the oscillator strengths of A3 in emission spectra.

  8. A preliminary feasibility study on natural analogue in Korea

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Chun Soo; Bae, Dae Seok; Kim, Kyung Su; Koh, Yong Kwon; Park, Byung Yun

    2000-03-01

    Preliminary study on the assessment of natural analogue study in Korea for the deep geological disposal of high-level radioactive waste was carried out. The project on natural analogue study in other countries are introduced. The uranium-bearing deposit in Okcheon belt are summarized, which reported to be uranium-bearing minerals in order to assess to feasibility for natural analogue study in Korea. Among the uranium-bearing deposits, the Deokpyeong area, reported to be the highest reservoir and grade, are selected as the study site, and the elementary investigation, including survey of radioactivity and geochemistry are carried out. According to the investigation of surface environment, the radioactivity and uranium content in the surface water and shallow groundwater does not show any anormal values. However, the radioactivity is expected to be increased in depth and the groundwater reacted with uranium-bearing graphite formation shows high unanium content, indicating the potential possibility for natural analogue study in Korea. In future, if more detail study are performed, the assessment of natural analogue study in Korea are expected.

  9. Poissons Characoïdes des Guyanes. I. Généralités. II. Famille des Serrasalmidae

    NARCIS (Netherlands)

    Géry, J.

    1972-01-01

    TABLE DES MATIÈ RES ENGLISH PREFACE AND SUMMARY......... 5 AVANT-PROPOS................. 8 RESUME ................... 9 PREMIERE PARTIE : GENERALITES SUR LES GUYANES ET LES POISSONS CHARACOÏDES................. 12 Chapitre 1. Introduction 1-1. Historique.................. 12 1- 2. Sources et

  10. Onlinespieler abseits des Mainstreams

    Directory of Open Access Journals (Sweden)

    Harald Baumgartlinger

    2012-12-01

    Full Text Available MMO(RPGs „Massively Multiplayer Online (Role-Playing Games“ nehmen einen Sonderstatus unter den Onlinespielen ein, welcher durch den wachsenden wirtschaftlichen Erfolg, insbesondere durch den „breakthrough hit“ (Duchenaut et al. 2006: 407 World of Warcraft (WoW, auch an Bedeutung für die Medien- und Kommunikationswissenschaft gewinnt (vgl. Inderst 2009: 15; vgl. Seifert/Jöckel 2008: 297. Der Primus des Genres, WoW, repräsentiert gemeinsam mit einigen nahezu identen Titeln insgesamt 85 Prozent der gespielten MMOGs (vgl. Williams et al. 2008: 999. Daher befasst sich auch die Mehrheit der vorliegenden Studien mit eben diesen Spielen. Neue Formen von MMO(Gs können jedoch zu ebenso neuartigen Spielerfahrungen führen und damit unterschiedliche Nutzungsmotive befriedigen (vgl. Seifert/Jöckel 2008: 309 und folglich zu einem gänzlich anderen Spielerleben führen. Während im Mainstream die kooperativen Spielerbeziehungen überwiegen, dominiert in Darkfall Online der soziale Wettbewerb. Der von Williams et al. 2008 verwendete Fragebogen diente als Rohling für die Kreation eines für die speziellen Anforderungen adaptierten Erhebungstools zur Erforschung der Spielertypologie und der Motive der Darkfall-Online-SpielerInnen. Die in der Onlinebefragung (N = 506 gesammelten Daten belegen, dass sich sowohl die Spielerdemographie, als auch die Motive der Spieler von den Mainstream MMOs unterscheiden. Zudem konnten realweltliche Eigenschaften der Spieler als signifikante Einflussfaktoren für die Spielzuwendung identifiziert werden.

  11. Terre des hommes

    CERN Multimedia

    Staff Association

    2012-01-01

    Transformez votre téléphone portable en geste de solidarité ! Collecte du 12 au 23 novembre 2012   Faites un geste simple et utile en déposant vos téléphones portables inutilisés dans les urnes installées dans les trois restaurants du CERN. En Suisse, une personne change tous les 12 à 18 mois de téléphone portable. La plupart de nos vieux appareils sont simplement laissés à l’abandon avec comme seule fonction de parer une éventuelle panne à venir. On  estime ainsi que 8 millions de portables sont inutilisés, alors qu'entre 30 et 50% peuvent être réutilisés. L'action Solidarcomm leur offre une deuxième vie ! Terre des Hommes Suisse, dans le cadre de la campagne Solidarcomm, collecte et valorise vos téléphones inutilis&...

  12. Recoupement des politiques: renforcer les initiatives de reddition de ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Au cours des dernières années, les acquisitions massives (achats, locations ou autres arrangements) de terres agricoles dans les pays en développement par des particuliers, des entreprises et des gouvernements étrangers ont eu des effets économiques positifs tout comme des effets négatifs sur les moyens de ...

  13. 107 Etude des facteurs de variation des prix d'intérêt des matières ...

    African Journals Online (AJOL)

    DELL

    Imen BELHADJ SLIMEN et Taha NAJAR. Etude des facteurs de variation des prix d'intérêt des matières premières de substitution utilisées dans les aliments concentrés des animaux d'élevage. Imen BELHADJ SLIMEN1,2* et Taha NAJAR1,2. 1Institut National Agronomique de Tunisie, Département Ressources Animales, ...

  14. Gyrodactylidae et Gyrodactylose des Salmonidae

    Directory of Open Access Journals (Sweden)

    MALMBERG G.

    1993-01-01

    Full Text Available Vingt et une espèces de Gyrodactylus de Salmonidae arrangées en six groupes sont présentées. Les observations concernant ces espèces dans les milieux naturels et en pisciculture sont résumées. Sur la base de données générales relatives aux espèces de Gyrodactylus en milieu naturel en Scandinavie et Baltique, les observations biologiques, écologiques et comportementales de G. salaris Malmberg, 1957 et G. derjavini MALMBERG et MALMBERG (1987 des salmonidae sauvages des rivières norvégiennes et suédoises sont présentées. La viviparité unique, la reproduction asexuée et sexuée et le pouvoir de reproduction chez les Gyrodactylus sont développés. La Gyrodactylose à G. salaris est abordée en milieu naturel, dans les rivières norvégiennes et en pisciculture, en Suède et au Danemark. L'étude ultrastructurale des blessures causées par G. salaris ainsi que les résultats expérimentaux sur les espèces norvégiennes et canadiennes sont présentés. La distribution géographique naturelle des Salmonidae, les modifications liées à l'homme et à l'activité économique ainsi que les Salmonidae élevés sont revus. La présence de six groupes d'espèces de Gyrodactylus en Amérique du Nord et Eurasie est discutée en fonction de la distribution géographique des espèces hôtes. Il est souligné qu'une propagation intercontinentale des espèces de Gyrodactylus de Salmonidae a dû être impossible à cause de leur origine limnique d'une part et de la salinité élevée des océans atlantique et pacifique d'autre part. Les exigences micro et macro environnementales des espèces sont discutées dans les conditions naturelles et les variations saisonnières, préférendums et tolérances du parasitisme sont signalés. L'effet des conditions de pisciculture sur les espèces de Gyrocactylus sont discutées : la capacité reproductrice et de propagation ainsi que la spécificité — stricte dans la nature — peuvent être influenc

  15. Promouvoir l'inclusion économique des jeunes et des femmes par l ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    entrepreneuriat à Madagascar. Le projet vise à promouvoir l'entrepreneuriat des femmes et des jeunes à Madagascar à travers le renforcement des capacités locales de recherche et des analyses pertinentes et utiles. En particulier les objectifs sont de ...

  16. Contamination des moules ( Mytilus galloprovincialis ) des côtes de ...

    African Journals Online (AJOL)

    Dans ce travail, nous avons etudie la contamination par les Hydrocarbures Aromatiques Polycycliques des moules recoltees au niveau des cotes de la region de Dakar. Les sites ont ete choisis en fonction des activites qui y sont developpees. Lfextraction des HAPs a ete faite au moyen dfun extracteur Soxhlet avec un ...

  17. Taux des lipides et des protéines et composition en acides gras du ...

    African Journals Online (AJOL)

    Taux des lipides et des protéines et composition en acides gras du tissu comestible des crustacés et des mollusques pêchés en Algérie : Effet du halofénozide (RH-0345) sur la composition en acides gras de Penaeus kerathurus (Crustacé, Décapode).

  18. Étude des impacts écologiques du dynamisme spatio-temporel des ...

    African Journals Online (AJOL)

    changement, (iv) élaborer une prospective des changements en 2050 et (v) évaluer les impacts du changement. Le change- ment des habitats naturels s'est déroulé au cours des temps mais il n'a ... assesses the impacts of habitat change on the resident glob- ... La gestion des changements, qui se manifestent presque.

  19. Ostéosynthèse des fractures des métacarpiens et des phalanges de ...

    African Journals Online (AJOL)

    Ostéosynthèse des fractures des métacarpiens et des phalanges de la main par mini plaque: à propos de 12 cas. Erraji Moncef, Derfoufi Abdelhafid, Kharraji Abdessamad, Agoumi Omar, Abdeljaouad Najib, Daoudi Abdelkrim, Yacoubi Hicham ...

  20. Concise synthesis of new bridged-nicotine analogues

    DEFF Research Database (Denmark)

    Crestey, François; Hooyberghs, Geert; Kristensen, Jesper Langgaard

    2012-01-01

    This study describes a very efficient strategy for the synthesis of two new bridged-nicotine analogues. Starting from either 4- or 3-chloropyridine the desired tricyclic ring systems are accessed in just three steps in 23% and 40% overall yield, respectively.......This study describes a very efficient strategy for the synthesis of two new bridged-nicotine analogues. Starting from either 4- or 3-chloropyridine the desired tricyclic ring systems are accessed in just three steps in 23% and 40% overall yield, respectively....

  1. Desert spring mounds: a potential analogue to Martian arid environments?

    Science.gov (United States)

    Franchi, F.; Frisia, S.

    2017-09-01

    Spring carbonates have been often considered as putative analogues of Martian arid environments. On Earth these are believed to form by the interaction of highly saline water and microbial communities, which favor the formation of authigenic micrite. Here we present new data from spring mounds in the western Makgadikgadi Pan (Botswana) and the Great Artesian Basin (South Australia). In both areas, upwelling of ground water give rise to mounds and layered deposits which are close morphological analogues of landforms documented on Mars. The authigenic carbonates and evaporites associated with the spring mounds retain evidence of microbial microfabric founded elsewhere, pointing to the potential existence of similar microbial in the extreme Martian conditions.

  2. Medical applications of analogue and digital telephone data links.

    Science.gov (United States)

    Hill, D W; Mable, S E; Payne, J P

    1976-07-20

    The increasing use of digital computer techniques for the analysis of signals such as the EEG, ECG, plethysmograms and cardiac output curves has led to the use of multichannel analogue frequency modulation telephone data links in the forward direction from the patient to the computer and digital links in the return direction. Single-channel analogue links are also being used for the surveillance of cardiac pacemaker patients and the television Viewphone offers the possibility of a visual contact between two centers. Examples will be given of the use of these various forms of telephone link.

  3. Naturally occurring crystalline phases: analogues for radioactive waste forms

    International Nuclear Information System (INIS)

    Haaker, R.F.; Ewing, R.C.

    1981-01-01

    Naturally occurring mineral analogues to crystalline phases that are constituents of crystalline radioactive waste forms provide a basis for comparison by which the long-term stability of these phases may be estimated. The crystal structures and the crystal chemistry of the following natural analogues are presented: baddeleyite, hematite, nepheline; pollucite, scheelite;sodalite, spinel, apatite, monazite, uraninite, hollandite-priderite, perovskite, and zirconolite. For each phase in geochemistry, occurrence, alteration and radiation effects are described. A selected bibliography for each phase is included

  4. Naturally occurring crystalline phases: analogues for radioactive waste forms

    Energy Technology Data Exchange (ETDEWEB)

    Haaker, R.F.; Ewing, R.C.

    1981-01-01

    Naturally occurring mineral analogues to crystalline phases that are constituents of crystalline radioactive waste forms provide a basis for comparison by which the long-term stability of these phases may be estimated. The crystal structures and the crystal chemistry of the following natural analogues are presented: baddeleyite, hematite, nepheline; pollucite, scheelite;sodalite, spinel, apatite, monazite, uraninite, hollandite-priderite, perovskite, and zirconolite. For each phase in geochemistry, occurrence, alteration and radiation effects are described. A selected bibliography for each phase is included.

  5. A Low-cost Multi-channel Analogue Signal Generator

    CERN Document Server

    Müller, F; The ATLAS collaboration; Shen, W; Stamen, R

    2009-01-01

    A scalable multi-channel analogue signal generator is presented. It uses a commercial low-cost graphics card with multiple outputs in a standard PC as signal source. Each color signal serves as independent channel to generate an analogue signal. A custom-built external PCB was developed to adjust the graphics card output voltage levels for a specific task, which needed differential signals. The system furthermore comprises a software package to program the signal shape. The implementation of the signal generator is presented as well as an application where it was successfully utilized.

  6. Neurochemical binding profiles of novel indole and benzofuran MDMA analogues.

    OpenAIRE

    Shimshoni, JA; Winkler, I; Golan, E; Nutt, D

    2016-01-01

    3,4-Methylenedioxy-N-methylamphetamine (MDMA) has been shown to be effective in the treatment of post-traumatic stress disorder (PTSD) in numerous clinical trials. In the present study, we have characterized the neurochemical binding profiles of three MDMA-benzofuran analogues (1-(benzofuran-5-yl)-propan-2-amine, 5-APB; 1-(benzofuran-6-yl)-N-methylpropan-2-amine, 6-MAPB; 1-(benzofuran-5-yl)-N-methylpropan-2-amine, 5-MAPB) and one MDMA-indole analogue (1-(1H-indol-5-yl)-2-methylamino-propan-1-...

  7. Natural analogues, paradigm for manmade repositories for radioactive wastes

    International Nuclear Information System (INIS)

    Pavelescu, M.; Pavelescu, A.

    2004-01-01

    Natural analogues are given by nature. They show the results of natural processes which have lasted thousands or millions of years. They provide an excellent example of what could happen in an underground site, offering in the same time the opportunity to test by observation and measurement, many of the geochemical processes that are expected to influence in a realistic and appropriate way, the predicted reliability of the radioactive waste repository over long periods of geological time. The natural analogue studies attempt to understand the multiprocessing complexity of the natural system, which contrasts with the limitations of the laboratory experiments and bring arguments to overcome the difficult time scale issue. By this the natural analogues are a useful paradigm for manmade repository for radioactive wastes. The paper discusses the implicit link in the public mind between natural analogues and manmade waste repository with an accent of the positive impact on public acceptance. It is also discussed the decisive qualities of the natural analogues concerning providing valid long term data and increasing the confidence of the public for manmade repositories. The debate is conducting in terms of sustainable development, having at base high-level principles in order to protect humans and their environment, both now and in the future, from potential hazards arising from such wastes. Safe radwaste management involves the application of technology and resources in a regulated manner so that the public, workers and the environment are protected in accordance with the accepted national and international standards. There are at least seven high-level principles which are mentioned in the paper. It is presented the general concept of the deep geological repository, very important for an acceptable solution for the management of nuclear waste, what is a prerequisite for a renewal of nuclear power. Further are introduced natural and archaeological (manufactured) analogue

  8. La convergence des rôles respectifs des relationnistes et des journalistes influence-t-elle la perception qu'ils ont les uns des autres?

    DEFF Research Database (Denmark)

    Valentini, Chiara

    2017-01-01

    la convergence des rôles respectifs des praticiens des relations publiques et des journalistes a un effet favorable sur la perception qu’ils ont les uns des autres. L’effet est plus marqué chez les praticiens des relations publiques, car leur vision de la profession en journalisme correspond à celle...... profession et de celle de leurs contreparties? Comment perçoivent-ils leurs rôles, leurs méthodes de travail et leurs interactions? Nous avons employé une méthode mixte, comprenant des entretiens en personne et des enquêtes en ligne, afin de recueillir et d’analyser les données. Les résultats indiquent que...

  9. Effets des extraits des feuilles de Alchornea cordifolia ...

    African Journals Online (AJOL)

    Faisant suite à deux études préliminaires, le but de cette étude est de rechercher, un effet antioxydant des feuilles de Alchornea cordifolia vis-à-vis du H2O2 relargué par le polynucléaire neutrophile stimulé. Deux extraits ont été préparés à partir des feuilles séchées : un macérât aqueux et un extrait à l'acétate d'éthyle.

  10. Promouvoir l'entrepreneuriat inclusif des jeunes et des femmes ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Un débat d'experts organisé par le CRDI s'attaque au mariage précoce lors du forum sur la condition des femmes à l'ONU. Des chercheurs appuyés par le CRDI parlent de leurs expériences au Comité sur les ONG lors du forum de la Commission de la condition de la femme. Voir davantageUn débat d'experts organisé par ...

  11. Impact des proprietes physicochimiques des sols de culture du ...

    African Journals Online (AJOL)

    La proportion moyenne de spores non-viables (55 %) est élevée. Il a été noté des corrélations positives entre les communautés de CMA et le magnésium (R = 0,65), la CEC (R = 0,69), l'argile (R = 0,74) et le limon grossier (R = 0,79). Par contre des corrélations négatives ont été obtenues avec le sable fin (R = -0,60) et le ...

  12. Evaluation economique des performances des services d'eau ...

    African Journals Online (AJOL)

    Abstract. En Algérie, le recours à des entreprises spécialisées dans la production et la distribution d'eau potable implique la nécessité de disposer d'évaluations du coût de ces activités. Cet article propose une étude micro-économétrique de la fonction de coût de l'alimentation en eau potable sur des données de panel, ...

  13. Evolution des intensites maximales annuelles des pluies horaires ...

    African Journals Online (AJOL)

    Ces résultats ne sont pas suffisants pour établir une relation entre les variations graduelles observées et le phénomène de changement climatique. La complexité du système climatique de l'Afrique de l'Ouest, la variabilité naturelle des données extrêmes et la longueur des séries utilisées suggèrent une prudence en la ...

  14. Evaluation des connaissances des enseignants du secondaire de l ...

    African Journals Online (AJOL)

    Evaluation des connaissances des enseignants du secondaire de l'atlantique au Benin sur les facteurs de risques du cancer du col de l'uterus en 2014. ... Les données ont été collectées à l'aide d'un questionnaire auto-administré. Une régression logistique pas à pas descendante a été faite. L'adéquation du modèle a été ...

  15. Comportement des polluants des eaux pluviales urbaines en ...

    African Journals Online (AJOL)

    C'est dans ce contexte que s'inscrit le présent travail qui porte sur la dégradation des paramètres organiques (DBO5, DCO, MES, O2, NO-3, pH, T, Fer, turbidité) dans différents milieux : naturel (rivière), canal artificiel, rivière (aux rives revêtues). Le traitement des données, effectué sur les trois sites d'observation sur deux ...

  16. Labellisation des miels et valorisation des spécifications régionales ...

    African Journals Online (AJOL)

    régionaux qui pilote les activités dénommé « Plate Forme Miel de Boeny ». Des outils ont été également conçus : des guides, des manuels, des supports de communication permettant de mieux gérer et de contrôles la qualité des miels. Des dispositifs de suivis et de contrôle sont en vue, mais aussi la création des ...

  17. Facteurs climatiques et environnementaux des risques palustres ...

    African Journals Online (AJOL)

    La santé des populations est tributaire des conditions climatiques et environnementales dans lesquelles elles vivent. La présente étude analyse les liens entre le climat, l'environnement et la prévalence du paludisme dans le Département des Collines. L'analyse des données pluviométriques, thermométriques et ...

  18. Etude des potentialites germinatives pour une regeneration ...

    African Journals Online (AJOL)

    Les différents aspects germinatifs du fruit de Neocarya macrophylla, ressource génétique fruitière spontanée du Niger, ont fait l'objet d'analyses. L'étude des performances germinatives de cette espèce a donc porté sur des graines récentes et des graines conservées à la température ambiante dans des flacons en verre ...

  19. Integration et exclusion des communautes : La curieuse ...

    African Journals Online (AJOL)

    Le sport s'est imposé aujourd'hui comme un puissant vecteur d'intégration. C'est par la médiation du sport que des individus et des cultures différentes se rencontrent, communient ensemble au cours des compétitions et finissent par se socialiser ou se « resocialiser ». C'est donc dire que le sport contribue à construire des ...

  20. ETUDE DE LA DISTRIBUTION DES CATIONS ECHANGEABLES

    African Journals Online (AJOL)

    SEI Joseph

    déterminé les pourcentages en silice et carbonates. Nous avons aussi mis au point la présence des ions chlorures en pourcentage assez important pouvant être responsable de la corrosion des aciers de frettage des tuyaux en béton précontraint et par conséquent des dégradations affectant ces tuyaux. La présence d'un.

  1. ETUDE DE LA DISTRIBUTION DES CATIONS ECHANGEABLES

    African Journals Online (AJOL)

    SEI Joseph

    pollution. L'objectif du présent travail est l'étude de la qualité des eaux superficielles et souterraines pour évaluer le degré de pollution provenant des lixiviats de la décharge et des cours d'eaux dans lesquels les ..... Les métaux lourds dosés ont montré une pollution métallique des eaux souterraine par rapport à la norme.

  2. Zur odonatenfauna des Fintlandsmoores (Landkreis ammerland)

    OpenAIRE

    Gueffroy, Daniel; Liekweg, Tammo

    2000-01-01

    Zur Untersuchung der Libellenfauna des Fintlandsmoores im Landkreis Ammerland wurden 1999 zehn Exkursionen durchgeführt. Der Untersuchungsschwerpunkt lag im bereich der dystrophen Torfstiche im süden sowie des unabgetorften Hochmoorrestes im Zentrum des Naturschutzgebietes. Insgesamt wurden 15 Libellenarten als bodenständig nachgewiesen. Aufgrund früherer Untersuchungen aus den Jahren 1973-78 und 1986 läßt sich die zunehmende Eutrophierung anhand der Veränderung des Artenspektr...

  3. ETUDE DE LA DISTRIBUTION DES CATIONS ECHANGEABLES

    African Journals Online (AJOL)

    SEI Joseph

    D'autre part, à cause de la corrélation directe entre l'étendue des inondations et les quantités de poissons et de pâturages fournies par la plaine, il y a eu dégradation des ... aux changements climatiques en zone sahélienne du Cameroun. Un des objectifs de notre étude était de préciser le comportement des agriculteurs ...

  4. Coalescence of organic solutions in acid and metal extraction by tri-alkylamines; Demixtion des solutions organiques lors de l'extraction des acides et des metaux par les trialcoylamines

    Energy Technology Data Exchange (ETDEWEB)

    Blain, J. [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

    1970-07-01

    The formation of two layers with tri-alkylammonium salts solutions in low polarity diluents could be explained on the basis of settling of micelles. Light scattering and viscosity measurements reveal that micelles size increases rather sharply before coalescence. The existence of micelles in the solution has been confirmed by ultracentrifuge experiments. The behaviour of these solutions, in general, is similar to that of colloidal soap solutions. The various parameters which promote third phase formation are: anion size in the order of Cl{sup -} {approx} Br{sup -} < NO{sub 3} < ClO{sub 4}{sup -}; extraction of excess acid; metal cation size in the order of UO{sub 2}{sup ++} < Pu{sup 4+} {approx} Th{sup 4+}; decreasing in the length of the n-alkyl chain in the alkyl-ammonium salts; decreasing in diluent polarity. The above phenomenon could be explained on the basis of the affinity between alkylammonium salts and organic solvent. The composition of the three phases is independent of the initial amine concentration for a fixed acid and metal concentration. This has been verified experimentally and is in conformity with phase rule. (author) [French] La demixtion des solutions organiques de sels de trialcoyl-ammonium dans les solvants peu polaires est provoquee par la decantation des micelles presentes dans la solution. Nous avons montre par viscosimetrie et surtout par diffusion de la lumiere que les micelles grossissent de facon importante juste avant demixtion. Des experiences d'ultracentrifugation nous ont permis de confirmer la presence de micelles. Le comportement de ces solutions est analogue a celui des solutions colloidales de savons dans l'eau. Ainsi tous les parametres qui font decroitre la compatibilite du sel d'ammonium R{sub 3}NH+ oooX{sup -} avec le solvant organique favorisent l'agregation du sel et par consequent la demixtion, soient: l'extraction des anions de taille croissante Cl{sup -} {approx} Br{sup -} < NO{sub 3} < Cl

  5. LES APPROCHES PSYCHOSOCIOLOGIQUES DES ORGANISATIONS

    Directory of Open Access Journals (Sweden)

    Deaconu Alecxandrina

    2008-05-01

    Full Text Available Les préoccupations pour bien comprendre la complexité des organisations sont bien connues dans la théorie et la pratique du management. La motivation la plus fréquente pour toutes les recherches et les investigationes faites a été fondée sur le besoin de savoir gérer les situations diverses en vue de maximiser la performance organisationnelle. En ce qui nous concerne, pour enrichir les informations disponibles, nous voulons élargir, dans notre communication, les approches traditionelles, focaliser l’attention sur la dimension psychologiques des organisations et présenter les mécanismes qui favorisent l’implication des salariés.

  6. Parasites et parasitoses des poissons

    OpenAIRE

    De Kinkelin, Pierre; Morand, Marc; Hedrick, Ronald; Michel, Christian

    2014-01-01

    Cet ouvrage, richement illustré, offre un panorama représentatif des agents parasitaires rencontrés chez les poissons. S'appuyant sur les nouvelles conceptions de la classification phylogénétique, il met l'accent sur les propriétés biologiques, l'épidémiologie et les conséquences cliniques des groupes d'organismes en cause, à la lumière des avancées cognitives permises par les nouveaux outils de la biologie. Il est destiné à un large public, allant du monde de l'aquaculture à ceux de la santé...

  7. L’Internet des objets

    OpenAIRE

    Benghozi, Pierre-Jean; Bureau, Sylvain; Massit-Folléa, Françoise

    2012-01-01

    L’ « internet des objets » est une dimension majeure de l’internet du futur. Mais tout le monde ne s’accorde pas encore sur sa définition, ni sur la mesure de son importance économique ou des risques qu’il induit. L’étude de nombreux rapports prospectifs et l’observation des innovations d’ores et déjà engagées a permis de mettre en relief les incertitudes techniques, économiques et socio-politiques qui pèsent sur cette véritable mutation programmée de l’internet et de proposer une approche eu...

  8. Aux origines des Jeux olympiques.

    Directory of Open Access Journals (Sweden)

    Isabelle Debilly

    2005-11-01

    Full Text Available Si les Jo modernes sont régulièrement sous les feux de l’actualité, soit par la répétition temporelle des Olympiades elle-même, soit par les enjeux économiques féroces qui découlent du choix des lieux, ceux de l’Antiquité sont en général cantonnés au domaine scolaire ou universitaire. Néanmoins, ils bénéficient tous les quatre ans d`un éclairage médiatique. L’ouvrage Olympie. La victoire pour les dieux est au croisement des deux domaines. En effet, écrit par un ...

  9. Agent des projets et des partenariats (h/f) | CRDI - Centre de ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    appuie la coordination des activités de mobilisation de ressources et des bailleurs de fonds (politiques et planification, etc.) et l'appui au Comité de gestion de la haute direction et au Conseil des gouverneurs;; facilite des relations clés entre la DPDA et des clients (programmes et bureaux régionaux), le conseiller juridique ...

  10. Quantification des apports et des exores d'un lac : cas du lac Fetzara ...

    African Journals Online (AJOL)

    ... permet de déterminer l'impact des facteurs environnementaux sur les variations de la composition chimique des eaux aux entrées et à la sortie du lac. Les résultats des analyses chimiques couplés aux débits mesurés dans différents points des Oueds Zied, Mellah, Hout et Meboudja ont permis le calcul des flux transitant ...

  11. Potentiel en biogaz des résidus agropastoraux et des excréments ...

    African Journals Online (AJOL)

    La potentialité en biogaz des excréments humains et des résidus agropastoraux du bassin versant du fleuve Sassandra (BVS) a été évaluée à partir des statistiques agricoles et de la population, ainsi que des indices de productivité de biogaz. Egalement, la mise en oeuvre des technologies de production de biogaz dans ...

  12. Prise en charge des urgences au service d'accueil des urgences ...

    African Journals Online (AJOL)

    Introduction: La prise en charge des patients dans les services d'accueil des urgences est une des meilleures vitrines d'un système de santé. En Afrique subsaharienne, la gestion des urgences se heurte à des difficultés humaines et matérielles. Le but de ce travail était d'évaluer les difficultés de prise en charge au Service ...

  13. Synthèse des faits empiriques et des leçons : Comment l ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    IDRC CRDI

    5 déc. 2013 ... and Flora Hewlett Foundation, le programme Croissance de l'Économie et Débouchés Économiques des Femmes ... des enseignements tirés au sujet des liens qui existent entre l'autonomisation économique des femmes ..... examens systématiques à l'aide des principes Cochrane/Campbell/3iE. Toutefois ...

  14. Récupération des eaux grises et des eaux pluviales pour l ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Récupération des eaux grises et des eaux pluviales pour l'agriculture urbaine et périurbaine à La Soukra, dans le gouvernorat d'Ariana (Tunisie). Jusqu'à la fin des années 1960, la plaine de la Soukra était une zone de verdure adjacente à Tunis. Au début des années 1970, les agriculteurs utilisaient des eaux usées ...

  15. Kodifikation des Privatrechts in Ungarn und die Tradition des römischen Rechts

    OpenAIRE

    Hamza, Gabor

    2015-01-01

    Das erste ungarische Zivilgesetzbuch wurde im Jahre 1959 verabschiedet. Das ungarische Zivilgesetzbuch ist am 1. Mai 1960 in Kraft getreten. Das ZGB spiegelt den Einfluss des schweizerischen Zivilgesetzbuches, des schweizerischen Obligationenrechts, des deutschen BGB und des Entwurfes des ungarischen Bürgerlichen Gesetzbuches aus dem Jahre 1928 wider. Das ungarische ZGB hat keinen Allgemeinen Teil, sondern nur in sieben Paragraphen gegliederte einleitende Bestimmungen. Der Kodex gliedert sic...

  16. Étude des politiques relatives à l'établissement des prix et à la ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Étude des politiques relatives à l'établissement des prix et à la taxation de l'alcool en Inde. L'Inde est le troisième marché mondial pour les ... Les données proviendront de sources multiples, dont le National Sample Survey Office et les départements des taxes d'accise des dix États. En fonction des résultats obtenus, les ...

  17. Architecture, des normes et des systèmes d'information libres, phase ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Architecture, des normes et des systèmes d'information libres, phase II (OASIS II) - Renforcement des capacités dans l'ensemble de l'Afrique. Sur presque tout le continent africain, la prestation des services de santé est limitée en raison des maigres ressources disponibles et de la charge de morbidité de plus en plus ...

  18. Intensifier l'inclusion financière des femmes et des jeunes en Afrique ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Intensifier l'inclusion financière des femmes et des jeunes en Afrique subsaharienne. Bien que d'énormes progrès aient été accomplis en vue d'offrir des services financiers à un plus large éventail de clients dans de nombreux pays de l'Afrique subsaharienne, des femmes et des jeunes marginalisés sont toujours laissés ...

  19. Perceptions locales de la manifestation des changements ...

    African Journals Online (AJOL)

    SARAH

    . PRPR. ERMA. DC. UD cluster 1 cluster 2. Pauvres. Riches et moyens. Figure 4. Positionnement des classes d'impacts socio-économiques des changements climatiques dans un système d'axes de l'analyse factorielle des ...

  20. Die Problematik des Begriffes hebraica veritas

    African Journals Online (AJOL)

    p1243322

    Nach ihm waren sowohl der Text des Tanak als auch sein Umfang Ausdruck der wahren Offenbarung Gottes an Israel, daher konnte nur diese Form des Alten Testaments die Wahrheit erhalten. Folgerichtig betrachtete er sie als Bibel der Verfasser des Neuen. Testaments und Norm für Lehre und Leben. Untersucht man die.

  1. Pecheries maritimes artisanales Togolaises : analyse des ...

    African Journals Online (AJOL)

    Pecheries maritimes artisanales Togolaises : analyse des debarquements et de la valeur commerciale des captures. K.M. Sedzro, E.D. Fiogbe, E.B. Guerra. Abstract. Description du sujet : La connaissance scientifique de la pression des pêcheries artisanales sur les ressources marines togolaises s'avère nécessaire pour ...

  2. Migration transnationale des Vietnamiennes en Asie | IDRC ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Souvent, cependant, les pays d'origine ne disposent pas des politiques ni des lois ayant force exécutoire qui permettraient d'assurer des pratiques d'embauche ... Women's movements in India are struggling to address problems arising from rapidly changing social relations and vulnerabilities associated with, among other ...

  3. Caractérisation des plantes médicinales à flavonoïdes des marchés ...

    African Journals Online (AJOL)

    Les plantes à flavonoïdes constituent un atout majeur pour le maintien de la santé. Le présent travail a été conduit dans deux marchés de la ville de Douala afin de valoriser l'utilisation des plantes à flavonoïdes dans la médecine traditionnelle. Des enquêtes ethnobotaniques réalisées auprès de 40 vendeurs des plantes ...

  4. Cardiotoxicité des psychotropes

    OpenAIRE

    TAHIRI, Abdallah

    2013-01-01

    Même à dose thérapeutique, les médicaments psychotropes sont susceptibles d'engendrer des troubles du rythme cardiaque graves avec risque létal concourant à expliquer la pré valence de la mort subite dans la population psychiatrique. Les situations cliniques à risque telles que poly médication (des psychotropes entre eux ou d'un psychotrope avec un non psychotrope allongeur de QTc), interactions médicamenteuses aussi bien pharmacodynamiques que pharmacocinétiques, traitement pa...

  5. (AJST) BIOSTRATIGRAPHIE DES FORAMINIFERES ET ...

    African Journals Online (AJOL)

    2Département de Géologie, Faculté des Sciences, Université d'Ibadan, Ibadan, Nigeria. 3Département de Géologie et Sciences de l'Environnement, Université de Buea, Cameroun. ARESUME:- 115 déblais de sondage et des ..... Cette méthode a été appliquée au lieu de la première apparition et de la denière apparition ...

  6. Synthesis, DNA interaction and antimicrobial activities of three rimantadine analogues

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Bing-Mi; Zhang, Jun [Department of Pharmacy, Liaoning University, Shenyang 110036 (China); Wang, Xin, E-mail: wangxinlnu@163.com [Department of Pharmacy, Liaoning University, Shenyang 110036 (China); Zhang, Li-Ping; Liu, Yang [Department of Pharmacy, Liaoning University, Shenyang 110036 (China); Niu, Hua-Ying [Jinan Dachpharm Development Co., Ltd., Jinan 250100 (China); Liu, Bin, E-mail: liubinzehao@163.com [Department of Pharmacy, Liaoning University, Shenyang 110036 (China)

    2015-03-15

    The interactions of three rimantadine analogues (RAs) with calf thymus deoxyribonucleic acid (ct-DNA) in buffer solution (pH 7.4) were investigated using berberine (BR) as a probe by various methods. Fluorescence studies revealed that the RAs interacted with DNA in vitro and the quenchings were all static. Furthermore, the binding modes of these compounds to DNA were disclosed as groove binding supported by absorption spectroscopy, viscosity measurement and denatured DNA experiment. The antimicrobial activities of the RAs were also evaluated in Staphylococcus aureus and Escherichia coli, and they all exhibited good bacteriostasic effects. The results might provide an important reference for investigation of the molecular mechanism associated with the DNA binding of the RAs. - Highlights: • Three rimantadine analogues were synthesized. • The RAs effectively quenched the intrinsic fluorescence of DNA via a static combination. • These analogues can bind to DNA via groove binding mode. • The antimicrobial activities of three analogues were also evaluated by the disk diffusion method.

  7. Are structural analogues to bisphenol A a safe alternative?

    DEFF Research Database (Denmark)

    Rosenmai, Anna Kjerstine; Dybdahl, Marianne; Pedersen, Gitte Alsing

    2013-01-01

    of which are found in foods and have been measured in humans. Due to the structural analogy there is an inherent risk that these compounds may lead to similar effects as BPA. The aim of this study was to characterize the toxicological profile of BPA and the five analogues using in vitro assays assessing...

  8. A new analogue of fatty alcohol from Tamarix hampeana L.

    Science.gov (United States)

    Aykac, Ahmet; Akgül, Yurdanur

    2010-01-01

    New analogues of a long-chain secondary alcohol (1) and laserine (2) were isolated from the flowers of Tamarix hampeana L. The isolated compounds were identified using 1D and 2D NMR, LCMS/APCI, and chemical methods. Laserine was isolated for the first time from T. hampeana L.

  9. Cytotoxicity of natural ginseng glycosides and semisynthetic analogues

    NARCIS (Netherlands)

    Atopkina, LN; Malinovskaya, GV; Elyakov, GB; Uvarova, NI; Woerdenbag, HJ; Koulman, A; Potier, P

    The cytotoxicity of natural glycosides from Ginseng, semisynthetic analogues and related triterpenes of the dammarane series, isolated from the leaves of the Far-East species of the genus Betula was studied in order to elucidate structure-activity relationships. Some of the compounds studied were

  10. Influence of Bakuchiol, a JH analogue from Bemchi ( Psoralea ...

    African Journals Online (AJOL)

    The influence of a juvenile hormone analogue (JHA), bakuchiol on the silk yield of silkworm, Bombyx mori L. was studied involving two popular commercial hybrids, KA x NB4D2 (bivoltine x bivoltine) and PM x NB4D2 (multivoltine x bivoltine). The compound was administered topically to 5th instars at 24, 48, 72 and 96 h as ...

  11. Difference in brain activations during appreciating paintings and photographic analogues

    Directory of Open Access Journals (Sweden)

    Yoshinori eMizokami

    2014-07-01

    Full Text Available Several studies have investigated neural correlates of aesthetic appreciation for paintings but to date the findings have been heterogeneous. This heterogeneity may be attributed to previous studies’ measurement of aesthetic appreciation of not only the beauty of paintings but also the beauty of motifs of the paintings. In order to better elucidate the beauty of paintings, it seems necessary to compare aesthetic appreciation of paintings and photographic analogues which included corresponding real images. We prepared for famous painters’ pictures and their photographic analogues which were set up to resemble each painting in order to investigate the hypothesis that there exist specific neural correlates associated with the aesthetic appreciation for paintings. Forty-four subjects participated in functional magnetic resonance study which required comparisons of aesthetic appreciation of paintings of still life and landscape versus photographic analogues including corresponding real images of still life and landscape. Bilateral cuneus and the left lingual gyrus were activated in the comparison of aesthetic appreciation of paintings versus photographic analogues. In conclusion, the present findings suggest a possibility of the existence of specific neural correlates associated with the aesthetic appreciation for paintings and that bilateral cuneus and the left lingual gyrus may be involved.

  12. Trehalose Analogues: Latest Insights in Properties and Biocatalytic Production

    Directory of Open Access Journals (Sweden)

    Maarten Walmagh

    2015-06-01

    Full Text Available Trehalose (α-d-glucopyranosyl α-d-glucopyranoside is a non-reducing sugar with unique stabilizing properties due to its symmetrical, low energy structure consisting of two 1,1-anomerically bound glucose moieties. Many applications of this beneficial sugar have been reported in the novel food (nutricals, medical, pharmaceutical and cosmetic industries. Trehalose analogues, like lactotrehalose (α-d-glucopyranosyl α-d-galactopyranoside or galactotrehalose (α-d-galactopyranosyl α-d-galactopyranoside, offer similar benefits as trehalose, but show additional features such as prebiotic or low-calorie sweetener due to their resistance against hydrolysis during digestion. Unfortunately, large-scale chemical production processes for trehalose analogues are not readily available at the moment due to the lack of efficient synthesis methods. Most of the procedures reported in literature suffer from low yields, elevated costs and are far from environmentally friendly. “Greener” alternatives found in the biocatalysis field, including galactosidases, trehalose phosphorylases and TreT-type trehalose synthases are suggested as primary candidates for trehalose analogue production instead. Significant progress has been made in the last decade to turn these into highly efficient biocatalysts and to broaden the variety of useful donor and acceptor sugars. In this review, we aim to provide an overview of the latest insights and future perspectives in trehalose analogue chemistry, applications and production pathways with emphasis on biocatalysis.

  13. An Analysis of an Autoclitic Analogue in Pigeons

    Science.gov (United States)

    Kuroda, Toshikazu; Lattal, Kennon A.; García-Penagos, Andrés

    2014-01-01

    Using a conditional discrimination procedure, pigeons were exposed to a nonverbal analogue of qualifying autoclitics such as "definitely" and "maybe." It has been suggested that these autoclitics are similar to tacts except that they are under the control of private discriminative stimuli. Instead of the conventional assumption…

  14. Trehalose Analogues: Latest Insights in Properties and Biocatalytic Production

    Science.gov (United States)

    Walmagh, Maarten; Zhao, Renfei; Desmet, Tom

    2015-01-01

    Trehalose (α-d-glucopyranosyl α-d-glucopyranoside) is a non-reducing sugar with unique stabilizing properties due to its symmetrical, low energy structure consisting of two 1,1-anomerically bound glucose moieties. Many applications of this beneficial sugar have been reported in the novel food (nutricals), medical, pharmaceutical and cosmetic industries. Trehalose analogues, like lactotrehalose (α-d-glucopyranosyl α-d-galactopyranoside) or galactotrehalose (α-d-galactopyranosyl α-d-galactopyranoside), offer similar benefits as trehalose, but show additional features such as prebiotic or low-calorie sweetener due to their resistance against hydrolysis during digestion. Unfortunately, large-scale chemical production processes for trehalose analogues are not readily available at the moment due to the lack of efficient synthesis methods. Most of the procedures reported in literature suffer from low yields, elevated costs and are far from environmentally friendly. “Greener” alternatives found in the biocatalysis field, including galactosidases, trehalose phosphorylases and TreT-type trehalose synthases are suggested as primary candidates for trehalose analogue production instead. Significant progress has been made in the last decade to turn these into highly efficient biocatalysts and to broaden the variety of useful donor and acceptor sugars. In this review, we aim to provide an overview of the latest insights and future perspectives in trehalose analogue chemistry, applications and production pathways with emphasis on biocatalysis. PMID:26084050

  15. An azumamide C analogue without the zinc-binding functionality

    DEFF Research Database (Denmark)

    Villadsen, Jesper; Kitir, Betül; Wich, Kathrine

    2014-01-01

    + - coordinating moiety. Herein, we describe the synthesis of an azumamide analogue lacking its native Zn 2+ -binding group and evaluation of its inhibitory activity against recombinant human HDAC1 – 11. Furthermore, kinetic investigation of the inhibitory mechanism of both parent natural product and synthetic...

  16. Evaluation of the antibacterial spectrum of drosocin analogues

    NARCIS (Netherlands)

    Bikker, F.J.; Kaman-van Zanten, W.E.; Vries-van de Ruit, A.M.B.C. de; Voskamp-Visser, I.; Hooft, P.A.V. van; Mars-Groenendijk, R.H.; Visser, P.C. de; Noort, D.

    2006-01-01

    Drosocin is a 19-mer, cationic antimicrobial peptide from Drosophila melanogaster. The aim of the study was to examine the antibacterial spectrum of unglycosylated drosocin analogues. Furthermore, the amino acid sequence of DnaK, drosocin's intracellular target, from susceptible species was aligned

  17. Research on uranium deposits as analogues of radioactive waste repositories

    International Nuclear Information System (INIS)

    Hardy, C.J.

    1987-01-01

    The disposal of highly radioactive waste deep underground in suitable geological formations is proposed by many countries to protect public health and safety. The study of natural analogues of nuclear waste repositories is one method of validating mathematical models and assuring that a proposed repository site and design will be safe. (author)

  18. Scattering matrices and expansion coefficients of martian analogue palagonite particles

    NARCIS (Netherlands)

    Laan, E.C.; Volten, H.; Stam, D.M.; Muñoz, O.; Hovenier, J.W.; Roush, T.L.

    2009-01-01

    We present measurements of ratios of elements of the scattering matrix of martian analogue palagonite particles for scattering angles ranging from 3° to 174° and a wavelength of 632.8 nm. To facilitate the use of these measurements in radiative transfer calculations we have devised a method that

  19. Reasoning by analogy: rational foundation of natural analogue studies

    International Nuclear Information System (INIS)

    Petit, J.-C.

    1992-01-01

    Long-term extrapolations concerning the safety of a nuclear waste repository cannot be satisfactorily made on the sole basis of short-term laboratory investigations. Most nuclear countries have hence developed an approach relying on the following research directions: 1. laboratory experiments; 2. in situ testing; 3. modeling; and 4. natural analogues, which are the only means by which very slow mechanisms can be identified and by which long-term predictions of models can be tested for pertinence (if not truly validated). Although the field of natural analogues has grown very rapidly in recent years, receiving support from varied specialists and institutions involved in radioactive waste disposal, there is not yet a full consensus on their actual usefulness. More problematic is the criticism sometimes made that analogical reasoning is not ''true science'' and that information retrieved from the study of natural analogues will always remain questionable. The present paper gives some clues about the exact status of reasoning by analogy, compared to more ''scientific'' ways of deriving information from investigated systems. It is not a thorough discussion of this very complex, and by far too philosophical issue but we hope, at least, to present to readers of papers devoted to natural analogue studies arguments showing that this approach has some sound foundation. (author)

  20. Using natural analogue studies in the secondary science curriculum

    International Nuclear Information System (INIS)

    Ebert, E.K.

    1995-01-01

    This paper discusses an atomic theory unit of a high school chemistry course taught in Nevada. The unit is based on the application of natural analogues to nuclear waste issues. The paper focuses on the students' reactions to the subject material

  1. A Short Review on Cardiotonic Steroids and Their Aminoguanidine Analogues

    Directory of Open Access Journals (Sweden)

    Arturo San Feliciano

    2000-01-01

    Full Text Available A short review on cardiotonic steroids and their analogues is presented. The natural, semisynthetic and synthetic derivatives, as well as their mechanism of action and structure-activity relationships are shown, with a special reference to aminoguanidine derivatives.

  2. Design and synthesis of epicocconone analogues with improved fluorescence properties.

    Science.gov (United States)

    Peixoto, Philippe A; Boulangé, Agathe; Ball, Malcolm; Naudin, Bertrand; Alle, Thibault; Cosette, Pascal; Karuso, Peter; Franck, Xavier

    2014-10-29

    Epicocconone is a natural latent fluorophore that is widely used in biotechnology because of its large Stokes shift and lack of fluorescence in its unconjugated state. However, the low photostability and quantum yields of epicocconone have limited its wider use, and in the absence of a total synthesis, this limitation has been a long-standing problem. Here we report a general strategy for the synthesis of epicocconone analogues that relies on a 2-iodoxybenzoic acid-mediated dearomatization and on the replacement of the triene tail of the natural product by an aromatic ring. This design element is general and the synthesis is straightforward, providing ready access to libraries of polyfunctional fluorophores with long Stokes shifts based on the epicocconone core. Our structural modifications resulted in analogues with increased photostability and quantum yields compared with the natural product. Staining proteomic gels with these new analogues showed significant lowering of the detection limit and a 30% increase in the number of low-abundance proteins detected. These epiccoconone analogues will substantially improve the discovery rate of biomarker needles in the proteomic haystack.

  3. Evaluative comparison of palm wine analogue and oil palm wine ...

    African Journals Online (AJOL)

    0.05 and P=0.01) in colour, odour, effervescence and general acceptability between palm wine analogue and oil palm wine. While there also was no significant difference in the tastes and balance of sweetness at P=0.01, a slight difference ...

  4. Vitamin E analogues and immune response in cancer treatment

    Czech Academy of Sciences Publication Activity Database

    Tomasetti, M.; Neužil, Jiří

    2007-01-01

    Roč. 76, - (2007), s. 463-491 ISSN 0083-6729 Institutional research plan: CEZ:AV0Z50520514; CEZ:AV0Z50520701 Keywords : vitamin E analogues * inducers of apoptosis * immune surveillance Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 3.889, year: 2007

  5. Analogue Building Blocks Based on Digital CMOS Gates

    DEFF Research Database (Denmark)

    Mucha, Igor

    1996-01-01

    Low-performance analogue circuits built of digital MOS gates are presented. Depending on the threshold voltages of the technology used the final circuits can be operated using low supply voltages. The main advantage using the proposed circuits is the simplicity and ultimate compatibility...... with the design of digital circuits....

  6. Brassinosteroids: Synthesis and activity of some fluoro analogues

    Czech Academy of Sciences Publication Activity Database

    Slavíková, Barbora; Kohout, Ladislav; Buděšínský, Miloš; Swaczynová, Jana; Kasal, Alexander

    2008-01-01

    Roč. 51, č. 13 (2008), s. 3979-3984 ISSN 0022-2623 R&D Projects: GA AV ČR IAA400550609 Institutional research plan: CEZ:AV0Z40550506; CEZ:AV0Z50380511 Keywords : brassinosteroids * fluor o analogues Subject RIV: CC - Organic Chemistry Impact factor: 4.898, year: 2008

  7. Contribution des radios communautaires a l'education des ...

    African Journals Online (AJOL)

    TIC » ont sur l'éducation des adolescents. Par une démarche d'étude essentiellement transversale, quantitative et qualitative, nous avons interrogé 160 sujets et les données collectées ont fait découvrir autant d'influences positives que ...

  8. Cartographie des zones d'intervention des partenaires techniques et ...

    African Journals Online (AJOL)

    Il s'agit des Communes ayant 7 à 10 partenaires (niveau 1), les. Communes ayant 11 à 14 (niveau 2) et les Communes ayant plus de 15 partenaires (niveau 3). Mots clés : Cartographie, Bénin, zones d'intervention, partenaires techniques et financiers (PTF), taux spatial d'intervention (TSI), taux de population couverte ...

  9. Traits morphologiques des graines et vigueur des jeunes plants de ...

    African Journals Online (AJOL)

    écologique du Sénégal afin de pouvoir sélectionner une meilleure semence qui sera destinée aux programmes de développement des énergies renouvelables. Morphological traits of seeds and seedling vigor of two sources of Jatropha curcas L. in ...

  10. Traits morphologiques des graines et vigueur des jeunes plants de ...

    African Journals Online (AJOL)

    SARAH

    écologique du Sénégal afin de pouvoir sélectionner une meilleure semence qui sera destinée aux programmes de développement des énergies renouvelables. Journal of Applied Biosciences 88:8249– 8255. ISSN 1997–5902 ...

  11. Evaluation des conditions de germination des noyaux de Grewia ...

    African Journals Online (AJOL)

    personnel

    31 janv. 2014 ... 1Laboratoire de Physiologie et Production Végétales, Université Marien NGOUABI,. Faculté des Sciences et Techniques, BP.69. Brazzaville, Republique du Congo. 2Ecole Nationale Supérieure d'Agronomie et Forestérie, Université Marien NGOUABI,. BP. 69. Brazzaville, Republique du Congo.

  12. Comparison of overlay metrology with analogue and digital cameras

    Science.gov (United States)

    Rigden, Timothy C.; Soroka, Andrew J.; Binns, Lewis A.

    2005-05-01

    Overlay metrology is a very demanding image processing application; current applications are achieving dynamic precision of one hundredth of a pixel or better. As such it requires an accurate image acquisition system, with minimal distortions. Distortions can be physical (e.g. pixel size / shape) or electronic (e.g. clock skew) in nature. They can also affect the image shape, or the gray level intensity of individual pixels, the former causing severe problems to pattern recognition and measurement algorithms, the latter having an adverse effect primarily on the measurement itself. This paper considers the artifacts that are present in a particular analogue camera, with a discussion on how these artifacts translate into a reduction of overlay metrology performance, in particular their effect on precision and tool induced shift (TIS). The observed effects include, but are not limited to, banding and interlacing. This camera is then compared to two digital cameras. The first of these operates at the same frame rate as the analogue camera, and is found to have fewer distortions than the analogue camera. The second camera operates with a frame rate twice that of the other two. It is observed that this camera does not exhibit the distortions of the analogue camera, but instead has some very specific problems, particularly with regards to noise. The quantitative data on the effect on precision and TIS under a wide variety of conditions, is presented. These show that while it is possible to achieve metrology-capable images using an analogue camera, it is preferable to use a digital camera, both from the perspective of overall system performance, and overall system complexity.

  13. Neurochemical binding profiles of novel indole and benzofuran MDMA analogues.

    Science.gov (United States)

    Shimshoni, Jakob A; Winkler, Ilan; Golan, Ezekiel; Nutt, David

    2017-01-01

    3,4-Methylenedioxy-N-methylamphetamine (MDMA) has been shown to be effective in the treatment of post-traumatic stress disorder (PTSD) in numerous clinical trials. In the present study, we have characterized the neurochemical binding profiles of three MDMA-benzofuran analogues (1-(benzofuran-5-yl)-propan-2-amine, 5-APB; 1-(benzofuran-6-yl)-N-methylpropan-2-amine, 6-MAPB; 1-(benzofuran-5-yl)-N-methylpropan-2-amine, 5-MAPB) and one MDMA-indole analogue (1-(1H-indol-5-yl)-2-methylamino-propan-1-ol, 5-IT). These compounds were screened as potential second-generation anti-PTSD drugs, against a battery of human and non-human receptors, transporters, and enzymes, and their potencies as 5-HT 2 receptor agonist and monoamine uptake inhibitors determined. All MDMA analogues displayed high binding affinities for 5-HT 2a,b,c and NE α2 receptors, as well as significant 5-HT, DA, and NE uptake inhibition. 5-APB revealed significant agonist activity at the 5-HT 2a,b,c receptors, while 6-MAPB, 5-MAPB, and 5-IT exhibited significant agonist activity at the 5-HT 2c receptor. There was a lack of correlation between the results of functional uptake and the monoamine transporter binding assay. MDMA analogues emerged as potent and selective monoamine oxidase A inhibitors. Based on 6-MAPB favorable pharmacological profile, it was further subjected to IC 50 determination for monoamine transporters. Overall, all MDMA analogues displayed higher monoamine receptor/transporter binding affinities and agonist activity at the 5-HT 2a,c receptors as compared to MDMA.

  14. Analogue model studies of induction effects at auroral latitudes

    Directory of Open Access Journals (Sweden)

    A. Viljanen

    1995-11-01

    Full Text Available In addition to field observations and numerical models, geomagnetic induction effects can be studied by scaled analogue model experiments. We present here results of analogue model studies of the auroral electrojet with an Earth model simulating the Arctic Ocean and inland conductivity structures in northern Fennoscandia. The main elements of the analogue model used were salt water simulating the host rock, an aluminium plate corresponding to the ocean and graphite pieces producing the inland highly conducting anomalies. The electrojet was a time-harmonic line current flowing at a (simulated height of 100 km above northern Fennoscandia. The period simulated was 9 min. The analogue model results confirmed the well-known rapid increase of the vertical field when the coast is approached from the continent. The increase of the horizontal field due to induced ocean currents was demonstrated above the ocean, as well as the essentially negligible effect of these currents on the horizontal field on the continent. The behaviour of the magnetic field is explained with a simple two-dimensional thin-sheet model. The range, or the adjustment distance, of the ocean effect inland was found to be some hundreds of kilometers, which also agrees with earlier results of the Siebert-Kertz separation of IMAGE magnetometer data. The modelled inland anomalies evidently had too large conductivities, but on the other hand, their influence decayed on scales of only some tens of kilometers. Analogue model results, thin-sheet calculations, and field observations show that the induction effect on the horizontal magnetic field Bx near the electrojet is negligible. On the other hand, the vertical component Bz is clearly affected by induced currents in the ocean. Evidence of this is the shift of the zero point of Bz 0-1° southwards from the maximum of Bx. The importance of these results are discussed, emphasizing the determination of ionospheric currents.

  15. Insecticidal action of synthetic girgensohnine analogues and essential oils on Rhodnius prolixus (Hemiptera: Reduviidae

    Directory of Open Access Journals (Sweden)

    Juliana Cuadros

    2017-03-01

    Conclusion: Synthetic girgensohnine analogues, and C. flexuosus and C. sinensis essential oils showed insecticidal activity in R. prolixus. Analogue 3 showed the greatest insecticidal activity among all molecules and oils evaluated under our laboratory conditions.

  16. The impact of watching educational video clips on analogue patients' physiological arousal and information recall

    NARCIS (Netherlands)

    Bruinessen, I.R. van; Ende, I.T. van den; Visser, L.N.; Dulmen, S. van

    2016-01-01

    OBJECTIVE: Investigating the influence of watching three educational patient-provider interactions on analogue patients' emotional arousal and information recall. METHODS: In 75 analogue patients the emotional arousal was measured with physiological responses (electrodermal activity and heart rate)

  17. The impact of watching educational video clips on analogue patients' physiological arousal and information recall

    NARCIS (Netherlands)

    van Bruinessen, I. R.; van den Ende, I. T. A.; Visser, L. N. C.; van Dulmen, S.

    2016-01-01

    Investigating the influence of watching three educational patient-provider interactions on analogue patients' emotional arousal and information recall. In 75 analogue patients the emotional arousal was measured with physiological responses (electrodermal activity and heart rate) and self-reported

  18. Altering the communication networks of multispecies microbial systems using a diverse toolbox of AI-2 analogues.

    Science.gov (United States)

    Gamby, Sonja; Roy, Varnika; Guo, Min; Smith, Jacqueline A I; Wang, Jingxin; Stewart, Jessica E; Wang, Xiao; Bentley, William E; Sintim, Herman O

    2012-06-15

    There have been intensive efforts to find small molecule antagonists for bacterial quorum sensing (QS) mediated by the "universal" QS autoinducer, AI-2. Previous work has shown that linear and branched acyl analogues of AI-2 can selectively modulate AI-2 signaling in bacteria. Additionally, LsrK-dependent phosphorylated analogues have been implicated as the active inhibitory form against AI-2 signaling. We used these observations to synthesize an expanded and diverse array of AI-2 analogues, which included aromatic as well as cyclic C-1-alkyl analogues. Species-specific analogues that disrupted AI-2 signaling in Escherichia coli and Salmonella typhimurium were identified. Similarly, analogues that disrupted QS behaviors in Pseudomonas aeruginosa were found. Moreover, we observed a strong correlation between LsrK-dependent phosphorylation of these acyl analogues and their ability to suppress QS. Significantly, we demonstrate that these analogues can selectively antagonize QS in single bacterial strains in a physiologically relevant polymicrobial culture.

  19. Analogue Electrical Circuit for Simulation of the Duffing-Holmes Equation

    DEFF Research Database (Denmark)

    Tamaseviciute, E.; Tamasevicius, A.; Mykolaitis, G.

    2008-01-01

    An extremely simple second order analogue electrical circuit for simulating the two-well Duffing-Holmes mathematical oscillator is described. Numerical results and analogue electrical simulations are illustrated with the snapshots of chaotic waveforms, phase portraits (Lissajous figures...

  20. The impact of watching educational video clips on analogue patients' physiological arousal and information recall.

    NARCIS (Netherlands)

    Bruinessen, I.R. van; Ende, I.T.A. van den; Visser, I.N.C.; Dulmen, S. van

    2016-01-01

    Objective: Investigating the influence of watching three educational patient–provider interactions on analogue patients’ emotional arousal and information recall. Methods: In 75 analogue patients the emotional arousal was measured with physiological responses (electrodermal activity and heart rate)

  1. La maison des mathématiques

    CERN Document Server

    Villani, Cédric; Moncorgé, Vincent

    2014-01-01

    Comment travaillent les mathématiciens ? C'est peut-être en se promenant dans les couloirs de la première des " maisons des mathématiques " de France, l'institut Henri Poincaré, que l'on trouvera quelques réponses. Le mathématicien Cédric Villani et le physicien Jean-Philippe Uzan nous invitent à découvrir cette discipline et ses acteurs. Au fil des pages on suit, à travers de superbes images signées du photographe Vincent Moncorgé, la façon dont se fabrique cette science qui reste souvent mystérieuse. Toutes les dimensions, scientifique, esthétique et poétique, des mathématiques sont convoquées grâce à des regards croisés : la diversité des inspirations des chercheurs, la source de leur créativité, l'imaginaire littéraire et artistique des mathématiques, la drôle de tribu des mathématiciens. Un voyage au cœur de cette " auberge espagnole " des mathématiques, campus " à la française " accueillant des centaines de chercheurs du monde entier, devenu un lieu d'émulation et d'éc...

  2. CINÉTIQUES ET ISOTHERMES DE FIXATION DE Zn(II ET Cd(II SUR DES RÉSINES ÉCHANGEUSES DE CATIONS

    Directory of Open Access Journals (Sweden)

    M HADIOUI

    2003-12-01

    Full Text Available Des méthodes relativement récentes, comme l’échange d’ions et l’extraction liquide-liquide, ont été largement utilisées pour séparer des métaux à l’état de traces. Pour ceux qui présentent notamment des propriétés analogues, la complexation par des agents chélatants s’avère nécessaire. Du fait de leur grande stabilité thermique et de la diversité des groupements fonctionnels des produits commerciaux disponibles, les résines ont été d’une grande utilité en analyse et dans l’industrie. Cette étude a trait à la rétention de métaux comme le cadmium et le zinc sur les résines acides Amberlite IRC-50, Dowex-50 X8 et Permutit C‑67. Les études en flacon ont mis en évidence une grande affinité de ces éléments pour les résines utilisées, et que l’équilibre est atteint rapidement (30 à 60 min. Les ions Zn2+ et Cd2+ n’utilisaient au maximum que 88 à 91 % de capacité totale des résines étudiées. Le traitement des résultats pour les faibles concentrations a montré que les isothermes sont du type Langmuir comme ceux obtenus par ailleurs sur des échangeurs minéraux.

  3. Etude des erreurs d'estimation des populations par la méthode des captures successives (DeLURY, 2 captures et des captures-recaptures (PETERSEN

    Directory of Open Access Journals (Sweden)

    LAURENT M.

    1978-01-01

    Full Text Available L'estimation des populations naturelles par capture-recapture et par captures successives est souvent entachée d'erreur car, dans de nombreux cas, l'hypothèse fondamentale d'égalité des probabilités de captures pour tous les individus dans le temps et dans l'espace n'est pas respectée. Dans le cas des populations de poissons envisagés ici, les captures ont lieu par la pêche électrique. On a pu chiffrer l'ordre de grandeur des erreurs systématiques faites sur l'estimation des peuplements, en fonction des conditions particulières, biotiques et abiotiques, des différents milieux inventoriés.

  4. REPARTITION BRANCHIALE DES MONOGENES Gotocotyla ...

    African Journals Online (AJOL)

    AISA

    Sur la base des données recoltées, nous avons défini et discuté de la localisation branchiale de ces deux monogènes dans le cas d'infestations monospécifiques et .... et Pyragraphorus hollisae. Monospecific infections of Trachinotus ovatus with Gotocotyla acanthura and. Pyragraphorus hollisae. Nbre = Nombre ...

  5. Les parcs des porcelainiers Haviland

    Directory of Open Access Journals (Sweden)

    Colette Chabrely

    2012-04-01

    Full Text Available Les parcs du Reynou et de Mont-Méry en Limousin, anciennes propriétés des porcelainiers Haviland, présentent l’un et l’autre un grand intérêt paysager et botanique. Dans les deux cas, l’attribution de la création est incertaine. Cet article propose pour le Reynou une analyse de documents figurés anciens permettant de préciser la chronologie des travaux du château et du parc. Pour Mont-Méry il s’agit de poser de nouveaux jalons pour une étude plus approfondie des sources et de la composition des jardins afin d’envisager de nouvelles pistes pour leur attribution.The Reynou and Mont-Méry parks near Limoges originally belonged to the city’s porcelain manufacturers, the Havilands. Both parks are of considerable interest in terms of their landscaping and their botany. In both cases, there is some uncertainty as to the identity of their designers. This article offers an analysis of the graphic representations of the Reynou park, clarifying the chronology of the creation of the château and its park. For the Mont-Méry park, the aim is to offer some guidelines for further research in the source material and on the design of the park itself, perhaps allowing for the designer to be identified.

  6. Reduction des effectifs ou licenciements

    CERN Multimedia

    Maiani, Luciano

    2002-01-01

    "Vous faites un amalgame entre la reduction en cours des effectifs du CERN (organisation europeenne pour la recherche nucleaire) et les economies que le laboratoire doit realiser dans les cinq ans a venir pour financer le projet de grand collisionneur de hadrons (Le Monde du 4 septembre)" (1/2 page).

  7. Neue Lycaeniden des Leiderner Museums

    NARCIS (Netherlands)

    Fruhstorfer, H.

    1916-01-01

    Einige Exemplare aus der Lycaena cleotas Guér.-Gruppe des Leidener Museums veranlassten mich das Material meiner Sammlung und meine Übersicht übe die Formen der Gattung Luthrodes, Iris 1915, pp. 47-49, nochmals nachzuprüfen. Bei dieser Gelegenheit fand ich, dass die unbedeutende Chilades laius Cram,

  8. Globalisation des marchés de capitaux et valorisation des actifs financiers

    OpenAIRE

    Dominique Pepin

    2000-01-01

    Ce papier examine les effets de la libéralisation ou globalisation des marchés de capitaux sur les prix des actifs financiers. La comparaison des modèles de segmentation (douce) et d'intégration des marchés montre que la libéralisation des marchés a pour effet de favoriser la hausse des prix des actifs. Nous montrons que ce résultat ne résiste pas à une généralisation de l'analyse. La prise en compte du caractère multiple et simultanée des processus de libéralisation des marchés de capitaux a...

  9. Biologie des populations des Monogènes Polystomatidae

    Directory of Open Access Journals (Sweden)

    TINSLEY R. C.

    1993-01-01

    Full Text Available Les cycles des monogènes polystomatidae montrent une très grande diversité. Parmi ceux qui infestent des amphibiens anoures, on devrait s'attendre à ce que la taille des populations parasites montre des différences prononcées, selon que des réinfestations interviennent régulièrement chaque année, ou qu'il n'y en ait qu'une dans la vie de l'hôte. Toutefois, à quelques exceptions près, les niveaux d'infestation sont généralement bas, quelle que soit la durée de vie de l'hôte. Les facteurs susceptibles de réguler les populations de polystomatidae parasites d'amphibiens anoures sont récapitulés ici, et nous nous penchons plus particulièrement sur les mécanismes contrôlant l'infestation et, par voie de conséquence, la survie post-infestation. Les effets d'un éventail de facteurs sont envisagés, parmi lesquels les contraintes environnementales externes (en particulier, la température, les facteurs liés à l'hôte (dont le comportement et la durée de vie et les facteurs propres au parasite (dont la compétition intraspécifique. Deux genres de Polystomatidae témoignent d'une régulation densité-dépendante des infrapopulations unique, contrôlée par la production de deux types de larves. Il existe des données de terrain et de laboratoire qui permettent de quantifier les effets de ces différents paramètres pour un certain nombre d'espèces de Polystomes. Les résultats obtenus pour Pseudodiplorchis americanus suggèrent que, même lorsqu'ils sont combinés, les effets de ces différents facteurs ne suffisent pas à rendre compte de la puissante régulation que l'on observe dans les populations naturelles où, malgré de massives infestations annuelles, les populations de parasites adultes sont faibles en effectif et remarquablement stables d'une année à l'autre. C'est la preuve indirecte qu'une importante régulation intervient par l'intermédiaire de l'immunité-hôte. Pour pouvoir pousser plus loin l

  10. Deficiencies in fat-soluble vitamins in long-term users of somatostatin analogue

    NARCIS (Netherlands)

    Fiebrich, H. -B.; van den Berg, G.; Kema, I. P.; Links, T. P.; Kleibeuker, J. H.; van Beek, A. P.; Walenkamp, A. M. E.; Sluiter, W. J.; de Vries, E. G. E.

    2010-01-01

    P>Background Somatostatin analogues are administered to control hormone hypersecretion in acromegaly and carcinoid patients. Somatostatin analogues can increase fat in the stools, which can lead to loss of fat-soluble vitamins. The effect of long-term somatostatin analogue use on vitamin levels

  11. On Using Current Steering Logic in Mixed Analogue-digital Circuits

    DEFF Research Database (Denmark)

    Lehmann, Torsten

    1998-01-01

    The authors investigate power supply noise in mixed analogue-digital circuits, arising from communication between the analogue and digital parts of the circuit. Current steering techniques and proper buffering are used to show which noise currents can be reduced and which cannot. In addition......, a high-swing current steering buffer for driving analogue switches or external digital signals is proposed....

  12. Alligator Rivers Analogue project. Application of scenario development method in evaluation of the Koongarra Analogue. Final Report - Volume 16

    International Nuclear Information System (INIS)

    Skagius, K.; Wingefors, S.

    1992-01-01

    The study of natural analogues has been established as one of the most important methods for validation of concepts and models applied for the assessment of long-term performance of repositories for nuclear waste. The objectives of such studies range from detailed investigations of processes and features on a small scale to attempts of explaining the evolution of whole sites. For studies of specific processes it may well be as important to consider the larger scale settings as boundary conditions. This appreciation of context and an integrated view may be as important for evaluation of most natural analogues as for performance assessments. This is more evident the more the evaluation depends on a knowledge about the evolution of the natural analogue. The attempted formulation of scenarios of the Koongarra Analogue has been based on the external conditions and external features. A rapid weathering of the host rock, i.e. the chlorite schist, is assumed to have started around the onset of the Pleistocene Ice Age (ca 1.6 Ma BP). The eventual oxidation and mobilization of the uranium ore could then have occurred under unsaturated or saturated conditions. This leads to the following major scenarios: (1) Uranyl Phosphates formed under unsaturated conditions, with a periodical evolution of the dispersion fan in conjunction with alternating dry (glacial) and wet (interglacial) periods during the Pleistocene Ice Age; (2) Uranyl Phosphates formed under unsaturated conditions as a single event, taking place either early or late during the Pleistocene Ice Age; (3)Uranyl Phosphates formed under saturated conditions, in conjunction with periods of higher and lower flow due to the climatic cycling. Although the original objectives may not have been fully achieved, this work is believed to contribute to a better understanding of the Koongarra Analogue as well as to give a basis for further scenario work

  13. Osteoporose und Genetik des Knochenstoffwechsels

    Directory of Open Access Journals (Sweden)

    Obermayer-Pietsch B

    2002-01-01

    Full Text Available Osteoporose ist in hohem Maß genetisch determiniert. Neue Wege der molekularbiologischen Forschung haben sich in den letzten Jahren auf diesem Gebiet etabliert. "Gene mapping" mit polymorphen genetischen Markern auf der Suche nach Phänotyp-assoziierten Genen ist ein aufwendiges, aber vielversprechendes Verfahren und wird durch die Erkenntnisse des Human Genome Projects beschleunigt. So wurde jüngst u. a. das Low-density Lipoprotein 5-Gen als wichtig für den Knochenstoffwechsel identifiziert. Kandidaten-gene wie Hormonrezeptor-, Cytokin- oder Kollagen-Gene werden hinsichtlich ihrer Gen-Gen- und Gen-Umwelt- Interaktionen untersucht und erlauben neue funktionelle Einsichten in Erkrankungen des Knochenstoffwechsels. Mutationen der Kollagen-Gene sind bei einigen seltenen Erkrankungen, wie dem Osteoporose-Pseudogliom-Syndrom oder der Osteogenesis imperfecta gefunden worden, könnten aber auch für häufige Varianten von Bindegewebsstörungen wie der congenitalen Hüftdysplasie verantwortlich sein, die etwa 10 % der weiblichen kaukasischen Bevölkerung in unterschiedlichem Ausmaß betrifft. Osteoporose am Schenkelhals und erhöhte Gelenkslaxizität sowie andere generalisierte Veränderungen des Knochen- und Kollagenstoffwechsels können hier möglicherweise ebenfalls durch Störungen des Kollagen I alpha 1-Gens erklärt werden. In Summe können wir zahlreiche neue Einsichten in die Pathophysiologie des Skelettsystems erwarten, die uns auch neue Zugangswege für Diagnostik und Therapie unserer Patienten ermöglichen werden.

  14. Géomorphologie et sédimentologie d'une plate-forme carbonatée isolée: l'Archipel des Glorieuses, SO Océan Indien

    OpenAIRE

    Prat, Sophie; Jorry, Stephan; Jouet, Gwenael; Le Roy, Pascal; Camoin, Gilbert; Vella, Claude; Caline, Bruno

    2013-01-01

    Améliorer nos connaissances sur la distribution des sédiments carbonatés dans les systèmes récifaux actuels sert à définir des analogues afin de mieux comprendre les réservoirs à hydrocarbures exploités dans les formations récifales fossiles. Bien que le rôle des changements du niveau marin, de la tectonique et de la sédimentation sur la dynamique et l'évolution des plates-formes carbonatés tropicales ait été largement étudié, la variabilité sédimentaire et les facteurs qui contrôlent cette h...

  15. Tirer parti des données massives des réseaux mobiles pour établir ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Tirer parti des données massives des réseaux mobiles pour établir des politiques de développement. Nombre de pays en développement sont dépourvus des capacités et des ressources requises pour recueillir et analyser des données aux fins de l'élaboration de politiques basées sur des données probantes.

  16. Etats des lieux des e-services internes dans les organisations

    OpenAIRE

    Orru, Fiona

    2017-01-01

    A l’heure actuelle, les techniques de communication interne ont évoluées. Au fil des années, la communication passe des outils dit classiques vers une communication de plus en plus orientée vers des outils virtuels et informatisés tels que l’internet, l’intranet, les réseaux sociaux, … Ce mémoire consistait à faire un « Etat des lieux des e-services internes existants dans les organisations ». La recherche de ce travail, soutenue par une étude quantitative, a permis d’analyser l’impact des e-...

  17. Phosphorylation of inositol 1,4,5-trisphosphate analogues by 3-kinase and dephosphorylation of inositol 1,3,4,5-tetrakisphosphate analogues by 5-phosphatase

    NARCIS (Netherlands)

    Dijken, Peter van; Lammers, Aleida A.; Ozaki, Shoichiro; Potter, Barry V.L.; Erneux, Christophe; Haastert, Peter J.M. van

    1994-01-01

    A series of P-32-labeled D-myo-inositol 1,3,4,5-tetrakisphosphate [Ins(1,3,4,5)P-4] analogues was enzymically prepared from the corresponding D-myo-inositol 1,4,5-trisphosphate [Ins(1,4,5)P-3] analogues using recombinant rat brain Ins(1,4,5)P-3 3-kinase and [gamma-P-32]ATP. Ins(1,4,5)P-3 analogues

  18. Évaluation de la valeur nutritive et recherche des substances ...

    African Journals Online (AJOL)

    SARAH

    30 juin 2016 ... et des lipides. Puis, l'évaluation a été effectuée sur ces échantillons pour rechercher la présence des alcaloïdes, des saponines, des quinones, des stéroïdes, des terpenoïdes, des flavonoïdes, des leucoanthocyanes, des tannoïdes et des hétérosides cyanogénétiques. Les teneurs moyennes en humidité ...

  19. Multistatic Surveillance and Reconnaissance: Sensor, Signals and Data Fusion (Surveillance et Reconnaissance Multistatiques : Fusion des capteurs, des signaux et des donnees)

    Science.gov (United States)

    2009-04-01

    capteurs , des signaux et des données) Research and Technology Organisation (NATO) BP 25, F-92201 Neuilly-sur-Seine Cedex, France RTO-EN-SET-133...Multistatiques : Fusion des capteurs , des signaux et des données) The material in this publication was assembled to support a Lecture Series under the...Surveillance et Reconnaissance Multistatiques : Fusion des capteurs , des signaux et des données (RTO-EN-SET-133) Synthèse Les systèmes radar

  20. La territorialisation des politiques environnementales

    Directory of Open Access Journals (Sweden)

    Amédée Mollard

    2010-10-01

    Full Text Available Le point de départ de cet article est la grande variabilité de la pollution nitrique diffuse de l’eau due à l’agriculture. Celle-ci dépend en particulier du climat, des types de sol et des systèmes de production agricole. Nos recherches réalisées de façon interdisciplinaire à partir de deux sites différents en France, montrent que cette hétérogénéité spatio-temporelle conditionne les pratiques agricoles mises en œuvre pour réduire la pollution au niveau de la norme admise. De ce fait, les pratiques les plus « coût-efficaces » diffèrent d’un territoire à l’autre, en fonction des caractéristiques locales. Ces résultats mettent donc en évidence une efficacité potentielle d’une territorialisation des politiques publiques. En théorie, de telles politiques sont considérées comme optimales par les économistes, car elles incitent les agents à moduler leurs efforts en fonction de la sensibilité du milieu. Mais, selon les études empiriques, cet avantage serait annulé par un coût élevé de mise en œuvre, de contrôle et de surveillance. Pour maintenir leur avantage sur des politiques uniformes, les politiques territorialisées devraient être mises en œuvre à un niveau spatial optimal. Un tel niveau devrait au minimum atteindre un compromis entre l’économie réalisée grâce à une modulation adaptée aux conditions locales et les sur-coûts dus à la décentralisation des solutions mises en œuvre. Cet article analyse la pertinence d’une prise en compte de ces spécificités par des politiques territorialisées. L’efficacité d’une régulation différenciée de la pollution nitrique est étudiée ici en évaluant l’importance de la variabilité spatiale des paramètres physiques et des coûts de la territorialisation.The paper starts with the wide variability of nonpoint water nitrogenous pollution generated by agriculture. This variability depends especially on climate, soil types and farming

  1. The analogue method for precipitation prediction: finding better analogue situations at a sub-daily time step

    Science.gov (United States)

    Horton, Pascal; Obled, Charles; Jaboyedoff, Michel

    2017-07-01

    Analogue methods (AMs) predict local weather variables (predictands) such as precipitation by means of a statistical relationship with predictors at a synoptic scale. The analogy is generally assessed on gradients of geopotential heights first to sample days with a similar atmospheric circulation. Other predictors such as moisture variables can also be added in a successive level of analogy. The search for candidate situations similar to a given target day is usually undertaken by comparing the state of the atmosphere at fixed hours of the day for both the target day and the candidate analogues. This is a consequence of using standard daily precipitation time series, which are available over longer periods than sub-daily data. However, it is unlikely for the best analogy to occur at the exact same hour for the target and candidate situations. A better analogue situation may be found with a time shift of several hours since a better fit can occur at different times of the day. In order to assess the potential for finding better analogues at a different hour, a moving time window (MTW) has been introduced. The MTW resulted in a better analogy in terms of the atmospheric circulation and showed improved values of the analogy criterion on the entire distribution of the extracted analogue dates. The improvement was found to increase with the analogue rank due to an accumulation of better analogues in the selection. A seasonal effect has also been identified, with larger improvements shown in winter than in summer. This may be attributed to stronger diurnal cycles in summer that favour predictors taken at the same hour for the target and analogue days. The impact of the MTW on the precipitation prediction skill has been assessed by means of a sub-daily precipitation series transformed into moving 24 h totals at 12, 6, and 3 h time steps. The prediction skill was improved by the MTW, as was the reliability of the prediction. Moreover, the improvements were greater for days

  2. Géographie des interfaces. Une nouvelle vision des territoires

    Directory of Open Access Journals (Sweden)

    Marie Redon

    2011-07-01

    Full Text Available Littéralement, une interface est une surface de séparation entre deux états distincts de la matière. Le terme, ayant cheminé de la physique à la biologie, et aussi désormais d’usage répandu en informatique. En géographie, l’usage du mot s’est développé dans les années 1980 et peut être défini comme un espace permettant la mise en relation de deux espaces/territoires différents, influencé par des échanges entre l’un et l’autre, et se distinguant par là-même des deux espaces contigus. Intégrant...

  3. Enquête de satisfaction des restaurants

    CERN Multimedia

    Staff Association

    2016-01-01

    Comité de surveillance des restaurants L’Association du personnel est représentée dans plusieurs comités dont le Comité de surveillance des restaurants (CSR) qui a pour mandat : de donner son avis sur toute question relative à la politique générale de l’Organisation en matière de restauration sur le site, y compris en ce qui concerne les termes et l’attribution des contrats d’exploitation des restaurants ; de définir dans le cadre des contrats d’exploitation des restaurants, les prestations correspondant aux besoins et, dans la mesure du possible, aux désirs du personnel ; de surveiller les prestations des restaurants, y compris en ce qui concerne la qualité et la préparation des produits ; de négocier avec les concessionnaires des restaurants au sujet des tarifs et de surveill...

  4. Administration et gestion des contrats XL

    CERN Document Server

    Senouf, J

    2000-01-01

    Les grands contrats de travaux génèrent un grand nombre de commandes (OSVC) passées par un grand nombre de responsables techniques. Ils sont généralement basés sur des bordereaux de prix associés à un éventail de conditions économiques adaptées aux besoins complexes et variés des multiples utilisateurs du CERN nécessitant des calculs sophistiqués. L'administration des commandes, le suivi des travaux et de la facturation doivent répondre aux besoins de tous les acteurs. Les responsables techniques doivent jouir de la plus large indépendance administrative dans le respect des règlements CERN et des conditions contractuelles. Le contrôle des métrés et décomptes doit être rigoureux et d'une traçabilité complète. L'utilisation des bases de données Oracle a déjà permis l'intégration des données administratives et techniques. Le Web nous invite à une communication totale et transparente entre les utilisateurs, les services techniques et les contractants. De nouveaux types de contrat so...

  5. Regroupement des statistiques sur le secteur des TIC et analyse ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    La présence et l'influence des technologies de l'information et de la communication (TIC) continuent de s'élargir et de s'accroître, tout comme leurs répercussions sur le développement économique. Toutefois, il reste encore beaucoup de travail à faire avant de pouvoir comprendre d'une manière systématique et ...

  6. Analyse des caractéristiques structurelles et des performances ...

    African Journals Online (AJOL)

    SARAH

    28 févr. 2014 ... 4p. Depieu ME, Doumbia S, Keli ZJ et Zouzou M, 2010. Typologie des exploitations en riziculture de la région de Saïoua, en zone forestière de la Côte d'Ivoire. Journal of Applied Biosciences. 35 :2301-2309. Doumbia, S et Depieu, M.E. 2013. Perception paysanne du changement climatique et stratégies.

  7. Planification optimisee des reseaux electriques par la methode des ...

    African Journals Online (AJOL)

    L'objectif principal de cette planification est l'optimisation des coûts de production de ces sources d'énergie électrique renouvelables et de transit de puissance dans les lignes du réseau lors de leur insertion dans le réseau électrique en tenant compte de la quantité maximale de tonne de CO2 évitée pour la protection de ...

  8. Étude cytogenetique des aberrations chromosomiques chez des ...

    African Journals Online (AJOL)

    Ces techniciens et volontaires témoins ont été soumis à l'épreuve de prélèvement de 5 ml de sang veineux au pli du coude dans des tubes d'héparine sodique. Après 48 ... These technicians and Volunteers (controls) were subjected to the test sample of 5 ml of venous blood to the elbow crease in sodium heparin tubes.

  9. Comportement des polluants des eaux pluviales urbaines en ...

    African Journals Online (AJOL)

    échange de l'oxygène de l'air avec les eaux usées [20]. 5. CONCLUSION. Ce travail a pour objectif d'évaluer le degré de dégradation de la pollution des eaux usées dans différents milieux (naturel, artificiel et semi naturel) en période humide.

  10. Prevision des ventes et efficacite des chaines logistiques - Essai de ...

    African Journals Online (AJOL)

    L'application de ces méthodes se fera dans une entreprise algérienne (la laiterie de RIO) spécialisée dans la production du yaourt. On étudiera les caractéristiques de la production et on estimera les ventes hebdomadaires en utilisant la méthode de Box et Jenkins. La modélisation des chaines logistiques se fera grâce à la ...

  11. DES EFFETS DURABLES DES VIES TRANSFORMÉES

    International Development Research Centre (IDRC) Digital Library (Canada)

    Son but est simple : veiller à ce que les personnes les plus vulnérables dans le monde, en particulier ... Simple et pourtant très efficace, le filtre biosable fournit de l'eau potable dans plus de 300 000 foyers de par le ... de rétablir la fertilité des sols dégradés par l'extraction de l'argile nécessaire à la fabrication de briques, ...

  12. Influence du mode de pollinisation et des caracteristiques des fruits ...

    African Journals Online (AJOL)

    La graine est l'organe principal de propagation du papayer (Carica papaya), chez qui les problèmes de germination sont récurrents. L'influence du mode de pollinisation et de la conservation des papayes sur la qualité de leurs semences est étudiée. Six cents fleurs hermaphrodites, de la lignée Solo n°8, sont marquées au ...

  13. Etudes des mecanismes de dissolution des phosphates naturels de ...

    African Journals Online (AJOL)

    Dans le cadre de la recherche sur la dissolution du phosphate calcique apatitique, une étude du mécanisme de cette dissolution basé sur la complexation des ions métalliques du minerai par deux acides humiques extraits d'un sol (AHS) et d'un compost (AHC) a été réalisée. L'ion calcium (Ca2+), ion majoritaire dans les ...

  14. Optoelectronic analogue signal transfer for LHC detectors, 1991

    CERN Document Server

    Dowell, John D; Homer, R J; Jovanovic, P; Kenyon, I; Staley, R; Webster, K; Da Via, C; Feyt, J; Nappey, P; Stefanini, G; Dwir, B; Reinhart, F K; Davies, J; Green, N; Stewart, W; Young, T; Hall, G; Akesson, T; Jarlskog, G; Kröll, S; Nickerson, R; Jaroslawski, S; CERN. Geneva. Detector Research and Development Committee

    1991-01-01

    We propose to study and develop opto-electronic analogue front-ends based on electro-optic intensity modulators. These devices translate the detector electrical analogue signals into optical signals which are then transferred via optical fibres to photodetector receivers at the remote readout. In comparison with conventional solutions based on copper cables, this technique offers the advantages of high speed, very low power dissipation and transmission losses, compactness and immunity to electromagnetic interference. The linearity and dynamic range that can be obtained are more than adequate for central tracking detectors, and the proposed devices have considerable radiation- hardness capabilities. The large bandwidth and short transit times offer possibilities for improved triggering schemes. The proposed R&D programme is aimed at producing multi-channel "demonstrator" units for evaluation both in laboratory and beam tests. This will allow the choice of the most effective technology. A detailed study wil...

  15. Ribosome-catalyzed formation of an abnormal peptide analogue

    International Nuclear Information System (INIS)

    Roesser, J.R.; Chorghade, M.S.; Hecht, S.M.

    1986-01-01

    The peptidyl-tRNA analogue N-(chloracetyl) phenylalanyl-tRNA/sup Phe/ was prepared by chemical aminoacylation and prebound to the P site of Escherichia coli ribosomes in response to poly(uridylic acid). Admixture of phenylalanyl-tRNA/sup Phe/ to the A site resulted in the formation of two dipeptides, one of which was found by displacement of chloride ion from the peptidyl-tRNA. This constitutes the first example of ribosome-mediated formation of a peptide of altered connectivity and suggests a need for revision of the current model of peptide bond formation. Also suggested by the present finding is the feasibility of utilizing tRNAs to prepare polypeptides of altered connectivity in an in vitro protein biosynthesizing system. [ 32 P]-oligo(rA), [ 3 H]- and [ 14 C] phenylalanines were used in the assay of the peptidye-tRNA analogue

  16. Concentration and second-gas effects in the water analogue.

    Science.gov (United States)

    Mapleson, W W; Korman, B

    1998-12-01

    The water analogue provides a visual model of the process of anaesthetic exchange. In the standard version, a single pipe connects the mouth container to the lung container and the conductance of this mouth-lung pipe is proportional to alveolar ventilation. This implies that inspired and expired ventilations are equal. In fact, with high inspired concentrations of nitrous oxide, early rapid uptake of gas by solution leads to a substantial difference between inspired and expired ventilation which in turn leads to concentration and second-gas effects. It is shown that by representing inspired and expired ventilations separately, and keeping one of them constant while varying the other to compensate for rapid uptake, concentration and second-gas effects are reproduced in the water analogue. Other means of reproducing the effects are reported but we believe that the first method is the most realistic and the most appropriate for teaching.

  17. A rationally designed CD4 analogue inhibits experimental allergic encephalomyelitis

    Science.gov (United States)

    Jameson, Bradford A.; McDonnell, James M.; Marini, Joseph C.; Korngold, Robert

    1994-04-01

    EXPERIMENTAL allergic encephalomyelitis (EAE) is an acute inflammatory autoimmune disease of the central nervous system that can be elicited in rodents and is the major animal model for the study of multiple sclerosis (MS)1,2. The pathogenesis of both EAE and MS directly involves the CD4+ helper T-cell subset3-5. Anti-CD4 monoclonal antibodies inhibit the development of EAE in rodents6-9, and are currently being used in human clinical trials for MS. We report here that similar therapeutic effects can be achieved in mice using a small (rationally designed) synthetic analogue of the CD4 protein surface. It greatly inhibits both clinical incidence and severity of EAE with a single injection, but does so without depletion of the CD4+ subset and without the inherent immunogenicity of an antibody. Furthermore, this analogue is capable of exerting its effects on disease even after the onset of symptoms.

  18. From the Canadian High Arctic to Mars by Analogue

    Science.gov (United States)

    Soare, R. J.; Pollard, W. H.

    2002-12-01

    Planetary scientists are limited in their understanding of physical bodies in the solar system by the lack of primary data or knowledge. Analogue science is science practised in absentia, precisely in those instances when a non-terrestrial physical environment lies beyond one's direct, empirical grasp. Recognising that some environments on Earth may mirror present or past conditions on Mars, planetary scientists have invoked terrestrial analogues with increasing regularity over the last thirty years as fonts of putative understanding. Notwithstanding its ubiquity in planetary science, analogical reasoning has stood, by and large, unconstrained by rules or guidelines of usage. In order to redress this imbalance we propose to take two steps: 1. introduce primary data on newly discovered pingos at Axel Heiberg Island in the Canadian High Arctic, and 2. coalesce these and related data on Martian glacial, peri-glacial and fluvio-glacial landforms as a model with which to evaluate the meaningfulness of analogical reasoning in planetary science.

  19. Optical analogue of relativistic Dirac solitons in binary waveguide arrays

    Energy Technology Data Exchange (ETDEWEB)

    Tran, Truong X., E-mail: truong.tran@mpl.mpg.de [Department of Physics, Le Quy Don University, 236 Hoang Quoc Viet str., 10000 Hanoi (Viet Nam); Max Planck Institute for the Science of Light, Günther-Scharowsky str. 1, 91058 Erlangen (Germany); Longhi, Stefano [Department of Physics, Politecnico di Milano and Istituto di Fotonica e Nanotecnologie del Consiglio Nazionale delle Ricerche, Piazza L. da Vinci 32, I-20133 Milano (Italy); Biancalana, Fabio [Max Planck Institute for the Science of Light, Günther-Scharowsky str. 1, 91058 Erlangen (Germany); School of Engineering and Physical Sciences, Heriot-Watt University, EH14 4AS Edinburgh (United Kingdom)

    2014-01-15

    We study analytically and numerically an optical analogue of Dirac solitons in binary waveguide arrays in the presence of Kerr nonlinearity. Pseudo-relativistic soliton solutions of the coupled-mode equations describing dynamics in the array are analytically derived. We demonstrate that with the found soliton solutions, the coupled mode equations can be converted into the nonlinear relativistic 1D Dirac equation. This paves the way for using binary waveguide arrays as a classical simulator of quantum nonlinear effects arising from the Dirac equation, something that is thought to be impossible to achieve in conventional (i.e. linear) quantum field theory. -- Highlights: •An optical analogue of Dirac solitons in nonlinear binary waveguide arrays is suggested. •Analytical solutions to pseudo-relativistic solitons are presented. •A correspondence of optical coupled-mode equations with the nonlinear relativistic Dirac equation is established.

  20. Somatostatin analogues labelled with 99mTc

    International Nuclear Information System (INIS)

    Obenaus, Esteban R.; Crudo, Jose L.; Edreira, Martin M.; Castiglia, Silvia G.

    1999-01-01

    Biological and radiochemical studies have been carried out on two labelled somatostatin analogues, the peptide RC-150 and the Tyr 3 -Octreotide. Both analogues have been labelled with 99m Tc using the direct and the indirect method and MAG-3 and HYNIC as chelating agents. By the direct method RC-150 was labelled using sodium ascorbate and dithionite as reducing agents. The radiochemical purity was 70%. By the indirect method, in the case of RC-160 with MAG-3 a radiochemical purity higher than 70% was attained while a purity of 100% was reached in the case of Tyr 3 -Octreotide with HYNIC. The biological distribution of HYNIC-Tyr 3 -Octreotide has been studied in rats. (author)

  1. Anti-cancer activities of diospyrin, its derivatives and analogues

    KAUST Repository

    Sagar, Sunil

    2010-09-01

    Natural products have played a vital role in drug discovery and development process for cancer. Diospyrin, a plant based bisnaphthoquinonoid, has been used as a lead molecule in an effort to develop anti-cancer drugs. Several derivatives/analogues have been synthesized and screened for their pro-apoptotic/anti-cancer activities so far. Our review is focused on the pro-apoptotic/anti-cancer activities of diospyrin, its derivatives/analogues and the different mechanisms potentially involved in the bioactivity of these compounds. Particular focus has been placed on the different mechanisms (both chemical and molecular) thought to underlie the bioactivity of these compounds. A brief bioinformatics analysis at the end of the article provides novel insights into the new potential mechanisms and pathways by which these compounds might exert their effects and lead to a better realization of the full therapeutic potential of these compounds as anti-cancer drugs. © 2010 Elsevier Masson SAS. All rights reserved.

  2. Solid-phase synthesis of polyamine toxin analogues

    DEFF Research Database (Denmark)

    Kromann, Hasse; Krikstolaityte, Sonata; Andersen, Anne J

    2002-01-01

    The wasp toxin philanthotoxin-433 (PhTX-433) is a nonselective and noncompetitive antagonist of ionotropic receptors, such as ionotropic glutamate receptors and nicotinic acetylcholine receptors. Polyamine toxins are extensively used for the characterization of subtypes of ionotropic glutamate...... receptors, in particular Ca(2+)-permeable AMPA and kainate receptors. We have previously shown that an analogue of PhTX-433 with one of the amino groups replaced by a methylene group, philanthotoxin-83 (PhTX-83) is a selective and potent antagonist of AMPA receptors. We now describe the solid...... of analogues, the acyl moiety of PhTX-83 was replaced by acids of different size and lipophilicity. Using electrophysiological techniques, PhTX-56 was shown to be a highly potent (K(i) = 3.3 +/- 0.78 nM) and voltage-dependent antagonist of homomeric GluR1 receptors and was more than 1000-fold less potent when...

  3. New Immunosuppressive Sphingoid Base and Ceramide Analogues in Wild Cordyceps

    Science.gov (United States)

    Mi, Jia-Ning; Han, Yuwei; Xu, Yingqiong; Kou, Junping; Wang, Jing-Rong; Jiang, Zhi-Hong

    2016-01-01

    A comprehensive identification of sphingoid bases and ceramides in wild Cordyceps was performed by integrating a sequential chromatographic enrichment procedure and an UHPLC-ultrahigh definition-Q-TOF-MS based sphingolipidomic approach. A total of 43 sphingoid bases and 303 ceramides were identified from wild Cordyceps, including 12 new sphingoid base analogues and 159 new ceramide analogues based on high-resolution MS and MS/MS data, isotope distribution, matching with the comprehensive personal sphingolipid database, confirmation by sphingolipid standards and chromatographic retention time rule. The immunosuppressive bioassay results demonstrated that Cordyceps sphingoid base fraction exhibits more potent immunosuppressive activity than ceramide fraction, elucidating the immunosuppressive ingredients of wild Cordyceps. This study represented the most comprehensive identification of sphingoid bases and ceramides from a natural source. The findings of this study provided an insight into therapeutic application of wild Cordyceps. PMID:27966660

  4. Haplopappus gracilis cell strains resistant to pyrimidine analogues.

    Science.gov (United States)

    Jones, G E; Hann, J

    1979-03-01

    Strains of Haplopappus gracilis (Nutt.) Gray cells resistant to 6-azauracil have been isolated from cultures of diploid cells. These strains are also resistant to 8-azaguanine, as is their parent. The variants are 100- to 125-fold more resistant to 6-azauracil than their parent, and they exhibit different spectra of cross resistance to other pyrimidine analogues. The phenotype of each variant is stable in the absence of selection. The majority of cells in cultures of the variants are diploid; all others examined were tetraploid. Initial rates of uptake of uracil are not reduced in the variants. Fluorouracil, to which two variants are resistant, is taken up by one of them as well as by the parent. Responses of the other two to fluorouracil are not correlated with decreased ability to accumulate this analogue.

  5. Higher-dimensional analogues of Donaldson-Witten theory

    International Nuclear Information System (INIS)

    Acharya, B.S.; Spence, B.

    1997-01-01

    We present a Donaldson-Witten-type field theory in eight dimensions on manifolds with Spin(7) holonomy. We prove that the stress tensor is BRST exact for metric variations preserving the holonomy and we give the invariants for this class of variations. In six and seven dimensions we propose similar theories on Calabi-Yau threefolds and manifolds of G 2 holonomy, respectively. We point out that these theories arise by considering supersymmetric Yang-Mills theory defined on such manifolds. The theories are invariant under metric variations preserving the holonomy structure without the need for twisting. This statement is a higher-dimensional analogue of the fact that Donaldson-Witten field theory on hyper-Kaehler 4-manifolds is topological without twisting. Higher-dimensional analogues of Floer cohomology are briefly outlined. All of these theories arise naturally within the context of string theory. (orig.)

  6. Localisation and mechanism of renal retention of radiolabelled somatostatin analogues

    Energy Technology Data Exchange (ETDEWEB)

    Melis, Marleen; Krenning, Eric P.; Bernard, Bert F.; Jong, Marion de [Erasmus MC, Department of Nuclear Medicine, Rotterdam (Netherlands); Barone, Raffaella [UCL, Centre of Nuclear Medicine and Laboratory of PET, Brussels (Belgium); Visser, Theo J. [Erasmus MC, Department of Internal Medicine, Rotterdam (Netherlands)

    2005-10-01

    Radiolabelled somatostatin analogues, such as octreotide and octreotate, are used for tumour scintigraphy and radionuclide therapy. The kidney is the most important critical organ during such therapy owing to the reabsorption and retention of radiolabelled peptides. The aim of this study was to investigate in a rat model both the localisation and the mechanism of renal uptake after intravenous injection of radiolabelled somatostatin analogues. The multi-ligand megalin/cubilin receptor complex, responsible for reabsorption of many peptides and proteins in the kidney, is an interesting candidate for renal endocytosis of these peptide analogues. For localisation studies, ex vivo autoradiography and micro-autoradiography of rat kidneys were performed 1-24 h after injection of radiolabelled somatostatin analogues and compared with the renal anti-megalin immunohistochemical staining pattern. To confirm a role of megalin in the mechanism of renal retention of [{sup 111}In-DTPA]octreotide, the effects of three inhibitory substances were explored in rats. Renal ex vivo autoradiography showed high cortical radioactivity and lower radioactivity in the outer medulla. The distribution of cortical radioactivity was inhomogeneous. Micro-autoradiography indicated that radioactivity was only retained in the proximal tubules. The anti-megalin immunohistochemical staining pattern showed a strong similarity with the renal [{sup 111}In-DTPA]octreotide ex vivo autoradiograms. Biodistribution studies showed that co-injection of positively charged d-lysine reduced renal uptake to 60% of control. Sodium maleate reduced renal [{sup 111}In-DTPA]octreotide uptake to 15% of control. Finally, cisplatin pre-treatment of rats reduced kidney uptake to 70% of control. Renal retention of [{sup 111}In-DTPA]octreotide is confined to proximal tubules in the rat kidney, in which megalin-mediated endocytosis may play an important part. (orig.)

  7. Rubrene analogues with the aggregation-induced emission enhancement behaviour

    DEFF Research Database (Denmark)

    Zhang, Xiaoxu; Sørensen, Jakob Kryger; Fu, Xiaowei

    2014-01-01

    In the light of the principle of aggregation-induced emission enhancement (AIEE), the rubrene analogue with orange light-emitting properties is designed and synthesized by substituting the phenyl side groups of rubrene with thienyl groups. To the best of our knowledge, this is the first report on...... on the synthesis of rubrene with AIEE behaviour, thus paving the way for the development of light-emitting rubrene derivatives. This journal is...

  8. Synthetic analogues of natural semiochemicals as promising insect control agents

    International Nuclear Information System (INIS)

    Ujvary, Istvan; Toth, Miklos; Guerin, Patrick

    2000-01-01

    After decades of research and development, insect pheromones and other semiochemicals became indispensable tools of ecologically based agricultural pest and disease vector management programmes with main uses as: 1) detection and population monitoring of emerging and migrating insects, 2) mass trapping of insects, 3) combined formulation of semiochemicals and insecticides ('lure-and-kill'), and 4) mating disruption with specially formulated pheromone components. In spite of their demonstrated safety and biodegradability, the direct application of these semiochemicals for pest control has not fulfilled initial expectations. Nonetheless considerable field experience has been accumulated (Carde and Minks 1995). Evidently, two important factors limit the practical potential of these substances: 1) inherent in their particular mode of action, semiochemicals, especially pheromones, are effectively cleared by specific enzymes in the insect antennae, and 2) some of these compounds contain labile functional moieties that are prone to degradation (oxidation, isomerisation and polymerisation) under field conditions. Appropriate chemical modifications of these natural compounds, however, can circumvent these problems by providing synthetic analogues (sometimes also called parapheromones or antipheromones; for early studies, see Roelofs and Comeau 1971, Payne et al. 1973) which in ideal cases are not only more potent and environmentally acceptable but more economical as well. It should also be mentioned that many effective attractants have been discovered through the empirical screening of synthetic chemicals, some of which have actually turned out to be structural relatives of natural semiochemicals of the particular insect. In this paper, selected case studies of analogues of sex pheromones and kairomones will be presented. The examples from our work include nitrile bioisosteres of labile aldehyde pheromone components of the cranberry girdler moth, Chrysoteuchia topiaria

  9. Evaluation of Anti-HIV-1 Mutagenic Nucleoside Analogues*

    Science.gov (United States)

    Vivet-Boudou, Valérie; Isel, Catherine; El Safadi, Yazan; Smyth, Redmond P.; Laumond, Géraldine; Moog, Christiane; Paillart, Jean-Christophe; Marquet, Roland

    2015-01-01

    Because of their high mutation rates, RNA viruses and retroviruses replicate close to the threshold of viability. Their existence as quasi-species has pioneered the concept of “lethal mutagenesis” that prompted us to synthesize pyrimidine nucleoside analogues with antiviral activity in cell culture consistent with an accumulation of deleterious mutations in the HIV-1 genome. However, testing all potentially mutagenic compounds in cell-based assays is tedious and costly. Here, we describe two simple in vitro biophysical/biochemical assays that allow prediction of the mutagenic potential of deoxyribonucleoside analogues. The first assay compares the thermal stabilities of matched and mismatched base pairs in DNA duplexes containing or not the nucleoside analogues as follows. A promising candidate should display a small destabilization of the matched base pair compared with the natural nucleoside and the smallest gap possible between the stabilities of the matched and mismatched base pairs. From this assay, we predicted that two of our compounds, 5-hydroxymethyl-2′-deoxyuridine and 5-hydroxymethyl-2′-deoxycytidine, should be mutagenic. The second in vitro reverse transcription assay assesses DNA synthesis opposite nucleoside analogues inserted into a template strand and subsequent extension of the newly synthesized base pairs. Once again, only 5-hydroxymethyl-2′-deoxyuridine and 5-hydroxymethyl-2′-deoxycytidine are predicted to be efficient mutagens. The predictive potential of our fast and easy first line screens was confirmed by detailed analysis of the mutation spectrum induced by the compounds in cell culture because only compounds 5-hydroxymethyl-2′-deoxyuridine and 5-hydroxymethyl-2′-deoxycytidine were found to increase the mutation frequency by 3.1- and 3.4-fold, respectively. PMID:25398876

  10. Evaluation of anti-HIV-1 mutagenic nucleoside analogues.

    Science.gov (United States)

    Vivet-Boudou, Valérie; Isel, Catherine; El Safadi, Yazan; Smyth, Redmond P; Laumond, Géraldine; Moog, Christiane; Paillart, Jean-Christophe; Marquet, Roland

    2015-01-02

    Because of their high mutation rates, RNA viruses and retroviruses replicate close to the threshold of viability. Their existence as quasi-species has pioneered the concept of "lethal mutagenesis" that prompted us to synthesize pyrimidine nucleoside analogues with antiviral activity in cell culture consistent with an accumulation of deleterious mutations in the HIV-1 genome. However, testing all potentially mutagenic compounds in cell-based assays is tedious and costly. Here, we describe two simple in vitro biophysical/biochemical assays that allow prediction of the mutagenic potential of deoxyribonucleoside analogues. The first assay compares the thermal stabilities of matched and mismatched base pairs in DNA duplexes containing or not the nucleoside analogues as follows. A promising candidate should display a small destabilization of the matched base pair compared with the natural nucleoside and the smallest gap possible between the stabilities of the matched and mismatched base pairs. From this assay, we predicted that two of our compounds, 5-hydroxymethyl-2'-deoxyuridine and 5-hydroxymethyl-2'-deoxycytidine, should be mutagenic. The second in vitro reverse transcription assay assesses DNA synthesis opposite nucleoside analogues inserted into a template strand and subsequent extension of the newly synthesized base pairs. Once again, only 5-hydroxymethyl-2'-deoxyuridine and 5-hydroxymethyl-2'-deoxycytidine are predicted to be efficient mutagens. The predictive potential of our fast and easy first line screens was confirmed by detailed analysis of the mutation spectrum induced by the compounds in cell culture because only compounds 5-hydroxymethyl-2'-deoxyuridine and 5-hydroxymethyl-2'-deoxycytidine were found to increase the mutation frequency by 3.1- and 3.4-fold, respectively. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

  11. The Two-Dimensional Analogue of General Relativity

    OpenAIRE

    Lemos, José P. S.; Sá, Paulo M.

    1993-01-01

    General Relativity in three or more dimensions can be obtained by taking the limit $\\omega\\rightarrow\\infty$ in the Brans-Dicke theory. In two dimensions General Relativity is an unacceptable theory. We show that the two-dimensional closest analogue of General Relativity is a theory that also arises in the limit $\\omega\\rightarrow\\infty$ of the two-dimensional Brans-Dicke theory.

  12. Matrix diffusion model. In situ tests using natural analogues

    International Nuclear Information System (INIS)

    Rasilainen, K.

    1997-11-01

    Matrix diffusion is an important retarding and dispersing mechanism for substances carried by groundwater in fractured bedrock. Natural analogues provide, unlike laboratory or field experiments, a possibility to test the model of matrix diffusion in situ over long periods of time. This thesis documents quantitative model tests against in situ observations, done to support modelling of matrix diffusion in performance assessments of nuclear waste repositories

  13. Matrix diffusion model. In situ tests using natural analogues

    Energy Technology Data Exchange (ETDEWEB)

    Rasilainen, K. [VTT Energy, Espoo (Finland)

    1997-11-01

    Matrix diffusion is an important retarding and dispersing mechanism for substances carried by groundwater in fractured bedrock. Natural analogues provide, unlike laboratory or field experiments, a possibility to test the model of matrix diffusion in situ over long periods of time. This thesis documents quantitative model tests against in situ observations, done to support modelling of matrix diffusion in performance assessments of nuclear waste repositories. 98 refs. The thesis includes also eight previous publications by author.

  14. (18)F-labelled metomidate analogues as adrenocortical imaging agents.

    Science.gov (United States)

    Erlandsson, Maria; Karimi, Farhad; Lindhe, Orjan; Långström, Bengt

    2009-05-01

    Two- and one-step syntheses of (18)F-labelled analogues of metomidate, such as 2-[(18)F]fluoroethyl 1-[(1R)-1-phenylethyl]-1H-imidazole-5-carboxylate (1), 2-[(18)F]fluoroethyl 1-[(1R)-1-(4-chlorophenyl)ethyl]-1H-imidazole-5-carboxylate (2), 2-[(18)F]fluoroethyl 1-[(1R)-1-(4-bromophenyl)ethyl]-1H-imidazole-5-carboxylate (3), 3-[(18)F]fluoropropyl 1-[(1R)-1-(4-bromophenyl)ethyl]-1H-imidazole-5-carboxylate (4) and 3-[(18)F]fluoropropyl 1-[(1R)-1-phenylethyl]-1H-imidazole-5-carboxylate (5) are presented. Analogues 1-5 were prepared by a two-step reaction sequence that started with the synthesis of either 2-[(18)F]fluoroethyl 4-methylbenzenesulfonate or 3-[(18)F]fluoropropyl 4-methylbenzenesulfonate. These were used as (18)F-alkylating agents in the second step, in which they reacted with the ammonium salt of a 1-[(1R)-1-phenylethyl]-1H-imidazole-5-carboxylic acid. One-step-labelling syntheses of 1, 2 and 5 were also explored. Analogues 1-4 were biologically validated by frozen-section autoradiography and organ distribution. Metabolite analysis was performed for 2 and 3. The radiochemical yield of the two-step synthesis was in the range of 10-29% and that of the one-step synthesis was 25-37%. Using microwave irradiation in the one-step synthesis of 1 and 2 increased the radiochemical yield to 46+/-3% and 79+/-30%, respectively. Both the frozen-section autoradiography and organ distribution results indicated that analogue 2 has a potential as an adrenocortical imaging agent, having the highest degree of specific adrenal binding and best ratio of adrenal to organ uptake among the compounds studied.

  15. Kidney protection during peptide receptor radionuclide therapy with somatostatin analogues

    Energy Technology Data Exchange (ETDEWEB)

    Rolleman, Edgar J.; Melis, Marleen; Valkema, Roelf; Krenning, Eric P.; Jong, Marion de [Erasmus MC, Department of Nuclear Medicine, V 220, Rotterdam (Netherlands); Boerman, Otto C. [Radboud University Hospital, Department of Nuclear Medicine, Nijmegen (Netherlands)

    2010-05-15

    This review focuses on the present status of kidney protection during peptide receptor radionuclide therapy (PRRT) using radiolabelled somatostatin analogues. This treatment modality for somatostatin receptor-positive tumours is limited by renal reabsorption and retention of radiolabelled peptides resulting in dose-limiting high kidney radiation doses. Radiation nephropathy has been described in several patients. Studies on the mechanism and localization demonstrate that renal uptake of radiolabelled somatostatin analogues largely depends on the megalin/cubulin system in the proximal tubule cells. Thus methods are needed that interfere with this reabsorption pathway to achieve kidney protection. Such methods include coadministration of basic amino acids, the bovine gelatin-containing solution Gelofusine or albumin fragments. Amino acids are already commonly used in the clinical setting during PRRT. Other compounds that interfere with renal reabsorption capacity (maleic acid and colchicine) are not suitable for clinical use because of potential toxicity. The safe limit for the renal radiation dose during PRRT is not exactly known. Dosimetry studies applying the principle of the biological equivalent dose (correcting for the effect of dose fractionation) suggest that a dose of about 37 Gy is the threshold for development of kidney toxicity. This threshold is lower when risk factors for development of renal damage exist: age over 60 years, hypertension, diabetes mellitus and previous chemotherapy. A still experimental pathway for kidney protection is mitigation of radiation effects, possibly achievable by cotreatment with amifostine (Ethylol), a radiation protector, or with blockers of the renin-angiotensin-aldosterone system. Future perspectives on improving kidney protection during PRRT include combinations of agents to reduce renal retention of radiolabelled peptides, eventually together with mitigating medicines. Moreover, new somatostatin analogues with lower

  16. Combinatorial Solid-Phase Synthesis of Balanol Analogues

    DEFF Research Database (Denmark)

    Nielsen, John; Lyngsø, Lars Ole

    1996-01-01

    The natural product balanol has served as a template for the design and synthesis of a combinatorial library using solid-phase chemistry. Using a retrosynthetic analysis, the structural analogues have been assembled from three relatively accessible building blocks. The solid-phase chemistry...... including MSNT-mediated esterification of both support-bound alcohols and carboxylic acids has been implemented successfully. Copyright (C) 1996 Elsevier Science Ltd....

  17. Alkaloids of family Amaryllidaceae and their analogues as potential drugs

    OpenAIRE

    Kavková, Zuzana

    2016-01-01

    Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Botany and Ecology Candidate: Zuzana Kavková Supervisor: doc. Ing. Lucie Cahlíková, Ph.D. Title of diploma thesis: Alkaloids of family Amaryllidaceae and their analogues as potential drugs The object of this diploma thesis was to prepare derivatives of alkaloids of Amaryllidaceae family and to deal with their biological activity. These alkaloids are famous for their antibacterial, antiinfectives, a...

  18. Antineoplastic Efficacy of Novel Polyamine Analogues in Human Breast Cancer

    Science.gov (United States)

    2006-06-01

    product analogs. J Am Chem Soc 1978; 100: 2551–2553. 39 Burri C, Brun R. Eflornithine for the treatment of human African trypanosomiasis . Parasitol Res...ototoxicity) at high therapeutic doses [29]. Currently, DFMO is the front-line agent in the treatment of African trypanosomiasis and is undergoing...Polyamine Analogues in Human Breast Cancer. PRINCIPAL INVESTIGATOR: Yi Huang, M.D., Ph.D. CONTRACTING ORGANIZATION: Johns

  19. Bisphenol A and Its Analogues Activate Human Pregnane X Receptor

    OpenAIRE

    Sui, Yipeng; Ai, Ni; Park, Se-Hyung; Rios-Pilier, Jennifer; Perkins, Jordan T.; Welsh, William J.; Zhou, Changcheng

    2012-01-01

    Background: Bisphenol A (BPA) is a base chemical used extensively in many consumer products. BPA and its analogues are present in environmental and human samples. Many endocrine-disrupting chemicals, including BPA, have been shown to activate the pregnane X receptor (PXR), a nuclear receptor that functions as a master regulator of xenobiotic metabolism. However, the detailed mechanism by which these chemicals activate PXR remains unknown. Objective: We investigated the mechanism by which BPA ...

  20. Quand voir c’est (faire penser. Motivation des chaînes anaphoriques et point de vue

    Directory of Open Access Journals (Sweden)

    Alain Rabatel

    2004-01-01

    Full Text Available Le point de vue narratif (PDV ne saurait se comprendre à partir de la pure et simple transposition des règles de perspective des sémiotiques de l’image fixe ou mobile : en effet, il serait naïf de croire analyser le PDV en ne recherchant dans les textes qu’un point de l’espace (analogue à celui occupé par le photographe, le peintre, le chef opérateur à partir duquel les objets seraient perçus et structurés, en laissant croire que ce point (Genette parle de « foyer » puisse être nettement i...

  1. Manipulating lightcone fluctuations in an analogue cosmic string

    Directory of Open Access Journals (Sweden)

    Jiawei Hu

    2018-02-01

    Full Text Available We study the flight time fluctuations in an anisotropic medium inspired by a cosmic string with an effective fluctuating refractive index caused by fluctuating vacuum electric fields, which are analogous to the lightcone fluctuations due to fluctuating spacetime metric when gravity is quantized. The medium can be realized as a metamaterial that mimics a cosmic string in the sense of transformation optics. For a probe light close to the analogue string, the flight time variance is ν times that in a normal homogeneous and isotropic medium, where ν is a parameter characterizing the deficit angle of the spacetime of a cosmic string. The parameter ν, which is always greater than unity for a real cosmic string, is determined by the dielectric properties of the metamaterial for an analogue string. Therefore, the flight time fluctuations of a probe light can be manipulated by changing the electric permittivity and magnetic permeability of the analogue medium. We argue that it seems possible to fabricate a metamaterial that mimics a cosmic string with a large ν in laboratory so that a currently observable flight time variance might be achieved.

  2. Amphetamine-Like Analogues in Diabetes: Speeding towards Ketogenesis

    Directory of Open Access Journals (Sweden)

    Natalia M. Branis

    2015-01-01

    Full Text Available Obesity is common in patients with type 1 and type 2 diabetes. Amphetamine-like analogues comprise the most popular class of weight loss medications. We present a case of a 34-year-old African American female with a history of type 1 diabetes, dyslipidemia, and obesity who developed diabetic ketoacidosis (DKA after starting Diethylpropion for the purpose of weight loss. Shortly after starting Diethylpropion, she developed nausea, vomiting, and periumbilical pain. Blood work revealed glucose of 718 mg/dL, pH 7.32 (7.35–7.45, bicarbonate 16 mmol/L (22–29 mmol/L, and anion gap 19 mmol/L (8–16 mmol/L. Urine analysis demonstrated large amount of ketones. She was hospitalized and successfully treated for DKA. Diethylpropion was discontinued. Amphetamine-like analogues administration leads to norepinephrine release from the lateral hypothalamus which results in the appetite suppression. Peripheral norepinephrine concentration rises as well. Norepinephrine stimulates adipocyte lipolysis and thereby increases nonesterified fatty acids (NEFA availability. It promotes β-oxidation of NEFA to ketone bodies while decreasing metabolic clearance rate of ketones. In the setting of acute insulin deficiency these effects are augmented. Females are more sensitive to norepinephrine effects compared to males. In conclusion, amphetamine-like analogues lead to a release of norepinephrine which can result in a clinically significant ketosis, especially in the setting of insulin deficiency.

  3. Natural analogue studies as supplements to biomineralization research

    International Nuclear Information System (INIS)

    McNeil, M.B.

    1995-01-01

    Chemical reactions can alter the chemistry and crystal structure of solid objects over archeological or geological times, while preserving external physical shapes. The reactions resulting in these structures offer natural analogues to laboratory experiments in biomineralization and to biologically influenced alteration of nuclear waste packages, and thus, they offer the only available way of validating models that purport waste package behavior over archaeological or geological times. Potential uses of such analogues in the construction and validation of hypothetical mechanisms of microbiological corrosion and biomineralization are reviewed. Evidence from such analogues suggests that biofilms can control materials alteration in ways usually overlooked. The newly hypothesized mechanisms involve control by biofilms of the cation flow near the solid surface and offer plausible mechanisms for the formation of mixed-cation minerals under conditions that would lead to dealloying in abiotic experiments; they also account for the formation of unusual minerals [such as posnjakite, Cu 4 SO 4 (OH) 6· H 2 O] and mineral morphologies unusual in corrosion [malachite, Cu 2 CO 3 (OH) 2 , rarely forms botryoidally under corrosion conditions and its occasional presence on archaeological objects that appear to have undergone microbiological corrosion may be related to biofilm phenomena

  4. Do film soundtracks contain nonlinear analogues to influence emotion?

    Science.gov (United States)

    Blumstein, Daniel T.; Davitian, Richard; Kaye, Peter D.

    2010-01-01

    A variety of vertebrates produce nonlinear vocalizations when they are under duress. By their very nature, vocalizations containing nonlinearities may sound harsh and are somewhat unpredictable; observations that are consistent with them being particularly evocative to those hearing them. We tested the hypothesis that humans capitalize on this seemingly widespread vertebrate response by creating nonlinear analogues in film soundtracks to evoke particular emotions. We used lists of highly regarded films to generate a set of highly ranked action/adventure, dramatic, horror and war films. We then scored the presence of a variety of nonlinear analogues in these film soundtracks. Dramatic films suppressed noise of all types, contained more abrupt frequency transitions and musical sidebands, and fewer noisy screams than expected. Horror films suppressed abrupt frequency transitions and musical sidebands, but had more non-musical sidebands, and noisy screams than expected. Adventure films had more male screams than expected. Together, our results suggest that film-makers manipulate sounds to create nonlinear analogues in order to manipulate our emotional responses. PMID:20504815

  5. Design and synthesis of biotin analogues reversibly binding with streptavidin.

    Science.gov (United States)

    Yamamoto, Tomohiro; Aoki, Kiyoshi; Sugiyama, Akira; Doi, Hirofumi; Kodama, Tatsuhiko; Shimizu, Yohei; Kanai, Motomu

    2015-04-01

    Two new biotin analogues, biotin carbonate 5 and biotin carbamate 6, have been synthesized. These molecules were designed to reversibly bind with streptavidin by replacing the hydrogen-bond donor NH group(s) of biotin's cyclic urea moiety with oxygen. Biotin carbonate 5 was synthesized from L-arabinose (7), which furnishes the desired stereochemistry at the 3,4-cis-dihydroxy groups, in 11% overall yield (over 10 steps). Synthesis of biotin carbamate 6 was accomplished from L-cysteine-derived chiral aldehyde 33 in 11% overall yield (over 7 steps). Surface plasmon resonance analysis of water-soluble biotin carbonate analogue 46 and biotin carbamate analogue 47 revealed that KD values of these compounds for binding to streptavidin were 6.7×10(-6)  M and 1.7×10(-10)  M, respectively. These values were remarkably greater than that of biotin (KD =10(-15)  M), and thus indicate the importance of the nitrogen atoms for the strong binding between biotin and streptavidin. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  6. THE PENA BLANCA NATURAL ANALOGUE PERFORMANCE ASSESSMENT MODEL

    Energy Technology Data Exchange (ETDEWEB)

    G. Saulnier and W. Statham

    2006-04-16

    The Nopal I uranium mine in the Sierra Pena Blanca, Chihuahua, Mexico serves as a natural analogue to the Yucca Mountain repository. The Pena Blanca Natural Analogue Performance Assessment Model simulates the mobilization and transport of radionuclides that are released from the mine and transported to the saturated zone. The Pena Blanca Natural Analogue Performance Assessment Model uses probabilistic simulations of hydrogeologic processes that are analogous to the processes that occur at the Yucca Mountain site. The Nopal I uranium deposit lies in fractured, welded, and altered rhyolitic ash-flow tuffs that overlie carbonate rocks, a setting analogous to the geologic formations at the Yucca Mountain site. The Nopal I mine site has the following analogous characteristics as compared to the Yucca Mountain repository site: (1) Analogous source--UO{sub 2} uranium ore deposit = spent nuclear fuel in the repository; (2) Analogous geology--(i.e. fractured, welded, and altered rhyolitic ash-flow tuffs); (3) Analogous climate--Semiarid to arid; (4) Analogous setting--Volcanic tuffs overlie carbonate rocks; and (5) Analogous geochemistry--Oxidizing conditions Analogous hydrogeology: The ore deposit lies in the unsaturated zone above the water table.

  7. Manipulating lightcone fluctuations in an analogue cosmic string

    Science.gov (United States)

    Hu, Jiawei; Yu, Hongwei

    2018-02-01

    We study the flight time fluctuations in an anisotropic medium inspired by a cosmic string with an effective fluctuating refractive index caused by fluctuating vacuum electric fields, which are analogous to the lightcone fluctuations due to fluctuating spacetime metric when gravity is quantized. The medium can be realized as a metamaterial that mimics a cosmic string in the sense of transformation optics. For a probe light close to the analogue string, the flight time variance is ν times that in a normal homogeneous and isotropic medium, where ν is a parameter characterizing the deficit angle of the spacetime of a cosmic string. The parameter ν, which is always greater than unity for a real cosmic string, is determined by the dielectric properties of the metamaterial for an analogue string. Therefore, the flight time fluctuations of a probe light can be manipulated by changing the electric permittivity and magnetic permeability of the analogue medium. We argue that it seems possible to fabricate a metamaterial that mimics a cosmic string with a large ν in laboratory so that a currently observable flight time variance might be achieved.

  8. Amphetamine-Like Analogues in Diabetes: Speeding towards Ketogenesis.

    Science.gov (United States)

    Branis, Natalia M; Wittlin, Steven D

    2015-01-01

    Obesity is common in patients with type 1 and type 2 diabetes. Amphetamine-like analogues comprise the most popular class of weight loss medications. We present a case of a 34-year-old African American female with a history of type 1 diabetes, dyslipidemia, and obesity who developed diabetic ketoacidosis (DKA) after starting Diethylpropion for the purpose of weight loss. Shortly after starting Diethylpropion, she developed nausea, vomiting, and periumbilical pain. Blood work revealed glucose of 718 mg/dL, pH 7.32 (7.35-7.45), bicarbonate 16 mmol/L (22-29 mmol/L), and anion gap 19 mmol/L (8-16 mmol/L). Urine analysis demonstrated large amount of ketones. She was hospitalized and successfully treated for DKA. Diethylpropion was discontinued. Amphetamine-like analogues administration leads to norepinephrine release from the lateral hypothalamus which results in the appetite suppression. Peripheral norepinephrine concentration rises as well. Norepinephrine stimulates adipocyte lipolysis and thereby increases nonesterified fatty acids (NEFA) availability. It promotes β-oxidation of NEFA to ketone bodies while decreasing metabolic clearance rate of ketones. In the setting of acute insulin deficiency these effects are augmented. Females are more sensitive to norepinephrine effects compared to males. In conclusion, amphetamine-like analogues lead to a release of norepinephrine which can result in a clinically significant ketosis, especially in the setting of insulin deficiency.

  9. On the Use of the Analogue Transformation Acoustics in Aeroacoustics

    Directory of Open Access Journals (Sweden)

    Umberto Iemma

    2017-01-01

    Full Text Available The objective of the paper is the assessment of the Analogue Transformation Acoustics (ATA in the design of acoustic metamaterial for aeronautical applications. The work focuses on the consistency of the background flow resulting from the application of the ATA with the equations governing the potential aerodynamics. Indeed, in case of acoustic perturbations propagating within moving media, the convective terms in the governing equations are responsible for the failure of formal invariance under the action of conformal mappings. The ATA approach overcomes this limitation, introducing the possibility of handling the convective form of the wave equation in a straightforward and elegant way. It is based on the concept of analogue space-time and fully relies on the analytical tools of Lorentzian differential geometry. The present paper analyses the relationship between the analogue velocity field with a realistic potential flow. The method is validated through numerical simulations using two widely assessed acoustic cloaking problems. The preliminary results obtained show that the use of numerical, quasi-conformal mappings can lead to transformed streamlines negligibly deviating from those of the potential velocity field satisfying the fluid-dynamic conservation laws, but with incompatible intensity of the local velocity.

  10. Isolement des bactéries lactiques à partir des produits laitiers ...

    African Journals Online (AJOL)

    Isolement des bactéries lactiques à partir des produits laitiers traditionnels Marocains et formulation d'un lait fermenté proche du Kéfir. S Lairini, N Beqqali, R Bouslamti, R Belkhou, F Zerrouq ...

  11. Poser et reposer des choix.

    Directory of Open Access Journals (Sweden)

    Corinne Van Hauwermeiren- Echement

    2009-10-01

    Full Text Available IntroductionEn 1955, le legs de la collection Franckignoul – composée notamment d’un ensemble de quatre panneaux du XVIe siècle – vient enrichir les collections du Musée des Beaux-Arts de la Ville de Liège (Belgique. La fermeture de ce dernier en 1976 débouche sur  la scission des collections. Une partie est donnée au Musée de l’Art Wallon, l’autre partie allant au Musée d’Art Moderne et d’Art Contemporain (Mamac. Toutes les œuvres n’entrant pas dans ces deux collections sont reléguées en r...

  12. Signature spectrale des grains interstellaires.

    Science.gov (United States)

    Léger, A.

    Notre connaissance de la nature des grains interstellaires reposait sur un nombre très restreint de signatures spectrales dans la courbe d'extinction du milieu interstellaire. Une information considérable est contenue dans les 40 bandes interstellaires diffuses dans le visible, mais reste inexploitée. L'interprétation récente des cinq bandes IR en émission, en terme de molécules d'hydrocarbures aromatiques polycycliques, est développée. Elle permet l'utilisation d'une information spectroscopique comparable, à elle seule, à ce sur quoi était basée jusqu'alors notre connaissance de la matière interstellaire condensée. Différentes implications de cette mise en évidence sont proposées.

  13. Rapport officiel des Jeux COVAN

    OpenAIRE

    2011-01-01

    Le rapport officiel de Vancouver 2010 se présente sous une forme inédite : un livre commémoratif officiel publié par Wiley, “Des plus brillants exploits” et un coffret multimédia, “Guide du rapport après les Jeux: le rapport officiel des Jeux Olympiques et Paralympiques d'hiver de 2010 à Vancouver”. Ce dernier contient une brochure explicative, deux CD-ROM comprenant les textes et résultats officiels, ainsi que le DVD d’un film commémoratif, “Le Canada à l’échelle 2010”. Les deux volumes sont...

  14. Des maux pour le taire

    OpenAIRE

    Dussy, Dorothée; Caisne, Léonore Le

    2011-01-01

    Cette enquête ethnographique effectuée dans une association parisienne d’entraide aux victimes d’inceste montre que les enfants sexuellement abusés par un familier doivent se construire sur une double approche de la réalité sociale : d’un côté un discours dominant qui prône l’interdit de l’inceste et le respect des valeurs ordinaires, de l’autre l’expérience quotidienne des viols perpétrés par un de ceux qui transmettent ces valeurs. Grâce à un annonciateur, l’inceste perd son caractère anomi...

  15. La caravane des animaux. Circulation des « orangs-outans » et des savoirs, reconfigurations des frontières de l’humain

    OpenAIRE

    Sebastiani, Silvia

    2018-01-01

    L’article interroge la présence des animaux exotiques dans la Grande-Bretagne des Lumières, et en particulier des « orangs-outans ». Il retrace la mobilité de ces bêtes, met en lumière les réseaux au long cours de leur circulation, dessine les multiples espaces de sociabilité de leur mise en observation et le foisonnement des registres de discours dont ils font l’objet. Mis au cœur des travaux d’anatomie comparée dès la fin du xviie siècle, les orangs-outans deviennent l’une des grandes attra...

  16. Zukunft des IT-Sourcing

    OpenAIRE

    von Jouanne-Diedrich, Holger; Zarnekow, Rüdiger; Brenner, Walter

    2006-01-01

    Im Oktober 2005 wurden in Kooperation mit der Analystenfirma Gartner zwei Workshops in Frankfurt am Main und in München zum Thema Sourcing & Benchmarking durchgeführt. Diese wurde vom Autor H. v. Jouanne-Diedrich mit moderiert und wissenschaftlich begleitet. Thema war die Zukunft des IT-Sourcing, deren Management sich zunehmend den Herausforderungen einer Industrialisierung der IT stellen muss. Die 30 teilnehmenden Personen stammten dabei sowohl aus den Geschäftsbereichen als auch aus Bereich...

  17. Aspects echocardiographiques et etiologiques des ...

    African Journals Online (AJOL)

    Buts: Décrire les aspects échocardiographiques et étiologiques des cardiomyopathies chez le noir africain. Patients et méthodes: Il s'est agit d'une étude prospective réalisée à la clinique cardiologique du CHUCampus de Lomé du 1er janvier 2007 au 31 décembre 2009. Etaient inclus dans l'étude, les patients consultants ...

  18. Déplacements des gouverneurs

    International Development Research Centre (IDRC) Digital Library (Canada)

    André Lavoie

    Transit. Tout endroit qui n'est pas considéré comme la destination où l'on se rend par affaires. Voyageur. Désigne un gouverneur dans le contexte du présent règlement. 5. Rôles et responsabilités. 5.1. Personnes participant au processus lié aux déplacements des gouverneurs. Toutes les personnes, dont les gouverneurs, ...

  19. Biostratigraphie des foraminiferes et interpretation ...

    African Journals Online (AJOL)

    Les résultats montre que du bas vers le haut de l'intervalle, les sédiments sont des argiles noires qui passent progresssivement aux sables argileux et finallement au grés au sommet du puits. Les grès sont plus ou moins bien triés, anguleux à subanguleux, fins à grossiers. La présence de la pyrite diagénétique dans toute ...

  20. Renforcement des capacités d'adaptation des acteurs ruraux ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Renforcement des capacités d'adaptation des acteurs ruraux béninois face aux changements climatiques. Ce projet de recherche-action cherche à réduire la vulnérabilité des populations et les amener à mieux s'adapter aux changements climatiques. Le projet agit à trois niveaux hiérarchiques de décision, en facilitant des ...

  1. Perceptions locales des déterminants de la fragmentation des îlots ...

    African Journals Online (AJOL)

    SARAH

    30 juin 2013 ... Bariba estiment que l'érosion hydrique est le principal facteur de la fragmentation des forêts denses. Tandis que pour les Lokpa, et les Peulh, la fragmentation des forêts denses a pour cause la pauvreté des sols. De même, les groupes socioculturels estiment que la durée de la fragmentation des forêts ...

  2. Incidence des prix et des taxes sur la consommation de produits du ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Incidence des prix et des taxes sur la consommation de produits du tabac en Argentine, en Bolivie et au Chili. Partout en Amérique du Sud, les adultes et les enfants font une grande consommation de tabac. Un nouveau projet de recherche se penchera sur les avantages et les limites des stratégies de fixation des prix et de ...

  3. Renforcement de l'autonomie des collectivités au moyen des ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Cette subvention permettra au ministère des Communications et des Technologies de l'information de l'Égypte ainsi qu'au fonds spécial réservé aux TI de consolider le modèle actuel des clubs de TI en Égypte, par l'entremise de services d'assistance sur demande, d'activités de formation à l'intention du personnel des ...

  4. L'enrichissement des sols et des semences permet d'améliorer la ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    nutritifs des sols (par un engrais à base de zinc) et les méthodes de transformation des aliments utilisées par les ménages. Le bioenrichissement est un moyen .... rapport coût-efficacité d'ajouter des micronutriments à l'alimentation et d'améliorer l'état nutritionnel. L'accroissement de la fertilité des sols et du rendement.

  5. La participation des femmes à la vie politique se traduit par des ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    La participation des femmes à la vie politique se traduit par des économies locales plus vigoureuses. 08 juin 2016. Image. Des femmes assistent à une réunion d'un groupe d'entraide près d'. Edgard Rodriguez - IDRC. Des femmes assistent à une réunion d'un groupe d'entraide près d'Hyderabad, en Inde. Keenara ...

  6. Gestion des côtes marocaines : renforcement des capacités d ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Gestion des côtes marocaines : renforcement des capacités d'adapter aux changements climatiques. Les répercussions de la hausse du niveau de la mer, de l'inondation des côtes et des ondes de tempête constituent un enjeu de plus en plus important en matière de politiques pour les planificateurs, les autorités locales ...

  7. Respect des normes de salubrité des aliments privées chez les ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Depuis quelques années, les petits exploitants agricoles des pays en développement se tournent vers l'étranger pour élargir leur marché. C'est pourquoi le respect des diverses normes de salubrité des aliments a gagné en importance. Le référentiel GLOBALGAP (anciennement EUREPGAP) est l'un des ensembles de ...

  8. OASIS : une architecture, des normes et des systèmes d'information ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    OASIS : une architecture, des normes et des systèmes d'information libres pour les services de santé en Afrique. Ce projet a pour but d'aider certains pays africains à concevoir puis à gérer des systèmes d'information sur la santé peu coûteux, viables et répondant aux besoins des établissements de santé et du secteur de ...

  9. Connaissances, attitudes et pratiques des prestataires de santé des ...

    African Journals Online (AJOL)

    ... des prestataires interrogés avaient respectivement une bonne connaissance des facteurs de risque et des moyens de dépistage. Les signes évocateurs et les examens complémentaires nécessaires au diagnostic du cancer du sein étaient connus par 15,3 % des prestataires. La définition du cancer du sein et les moyens ...

  10. Evaluation de l'abondance des kystes des protozoaires flagellés ...

    African Journals Online (AJOL)

    Les analyses statistiques montrent des corrélations significatives (P ≤ 0,05) entre la densité des kystes des protozoaires flagelles identifiées et les paramètres physico-chimiques tels que les MES, l'oxydabilité et la turbidité. Conclusions et application des resultsts: Les plantes doivent être bien lavées, désinfectées et bien ...

  11. Accès à l'eau : des solutions techniques et sociales aident des ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Grâce à la modélisation par ordinateur faisant appel à des techniques de pointe et à la consultation des collectivités, l'organisme bolivien Agua Sustentable a trouvé des solutions politiques à des conflits qui auraient pu s'avérer désastreux au sujet de l'accès à l'eau. Cet organisme de recherche subventionné par le CRDI a ...

  12. Diagnostic des capteurs pour la commande des entrainements électriques

    OpenAIRE

    Diao , Sidath; DIALLO , Demba; MAKNI , Zaatar; Marchand , Claude

    2014-01-01

    Ce papier traite de la détection des défauts sur les capteurs pour un ensemble Machine Synchrone et Onduleur par des méthodes d'estimation d'état. Les capteurs à surveiller dans notre cas sont ceux de la position/vitesse et des courants de phase. Des résultats expérimentaux illustrent l'approche utilisée.

  13. Contribution des TICs à l'abandon des mutilations génitales ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le projet sera mené au Burkina Faso, au Mali et au Sénégal avec des collectifs de jeunes de communautés excisantes, disposant d'infrastructure de TIC et où sont menées des actions sur l'excision. Il permettra de sensibiliser des jeunes, des décideurs communautaires et le public à travers de rencontres réelles et ...

  14. Inventaire floristique et écologie des algues des rivières Kambo et ...

    African Journals Online (AJOL)

    L'objectif général de l'étude est de contribuer à la connaissance des algues des rivières Kambo et Longmayagui de Douala. Les objectifs spécifiques ont consisté à mesurer les paramètres physico-chimiques des rivières, de faire les inventaires des algues et d'en dégager les variations spatio-temporelles en relation avec ...

  15. Des collectivités forestières du Nigeria prennent des mesures pour ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Des collectivités forestières du Nigeria prennent des mesures pour réduire les émissions de carbone. 08 juin 2016. Image. Deforestation in Nigeria. Foreign and Commonwealth Office. En Afrique subsaharienne, il est crucial de conserver et de protéger les forêts pour assurer la durabilité des moyens de subsistance des ...

  16. Effets des changements socio-économiques sur les stratégies des ...

    African Journals Online (AJOL)

    Effets des changements socio-économiques sur les stratégies des agriculteurs des zones cotonnières d'Afrique Centrale. ... Cameroon Journal of Agricultural Science ... défensive de diversification des activités monétaires dès qu'un créneau économique peut être exploité, créant ainsi de nouvelles filières économiques.

  17. Sécurité des femmes et des personnes lesbiennes, gaies ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Sécurité des femmes et des personnes lesbiennes, gaies, bisexuelles, transgenres, intersexuées dans les régions touchées par les conflits en Colombie. La Colombie est en train de conclure les négociations de paix avec le groupe de rebelles des Forces armées révolutionnaires de Colombie (FARC). Une des attentes ...

  18. Évaluation des caractéristiques des stomates chez le palmier à huile ...

    African Journals Online (AJOL)

    SARAH

    31 août 2016 ... stomates chez le palmier à huile normal diploïde afin d'appliquer dans le futur les méthodes de la. Biotechnologie. Les objectifs spécifiques portent sur l'évaluation de la densité, de la longueur et de la largeur des stomates des feuilles de palmier à huile en fonction des variétés, de l'âge de la plante et des.

  19. Caractérisation des peuplements ligneux des parcs à Faidherbia ...

    African Journals Online (AJOL)

    SARAH

    31 oct. 2015 ... 1Département de Gestion des Ressources Naturelles (DGRN), Institut National de la Recherche Agronomique du. Niger (INRAN), BP 240 Maradi, Niger .... faciliter la gestion de ces ressources au profit des populations. Cette étude ...... très peu des rejets des souches relatifs à ces espèces ont été observés.

  20. L'alkylidénolyse des oléfines catalysée par les complexes des métaux de transition Alkylidenolysis of Olefins Catalysed by Transition-Metal Complexes

    Directory of Open Access Journals (Sweden)

    Chauvin Y.

    2006-11-01

    Full Text Available Une grande variété de complexes de métaux de transition, homogènes ou hétérogènes, sont susceptibles de provoquer la scission des doubles et triples liaisons carbone-carbone. Les caractéristiques générales de la réaction de disproportion (x métathèse » des oléfines acycliques et de la polymérisation des oléfines cycliques impliquent l'existence d'intermédiaires de réaction dont les analogues stables sont connus. Les applications de la réaction sont variées : interconversion des oléfines et synthèse de polymères de structures nouvelles. A great variety of homogeneous or heterogeneous transition metal complexes may induce the splitting of the double and triple carbon-carbon bonds. The general characteristics of the disproportionation reaction (x metathesis » of acyclic olefins and cyclic-olefin polymerization imply the existence of reaction intermediates whose stable analogs are known. This reaction has various applications such as olefin interconversion and synthesizing polymers with new structures.

  1. Des pommes de terre plus saines et plus nutritives contribuent à la ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    De plus, les activités de recherche impliquant des femmes ont permis de redécouvrir des recettes ancestrales et des connaissances culinaires pour assaisonner des aliments avec des produits naturels plutôt qu'avec des condiments artificiels à haute teneur en sodium. Des institutions et des universités publiques ont.

  2. THE PENA BLANCA NATURAL ANALOGUE PERFORMANCE ASSESSMENT MODEL

    International Nuclear Information System (INIS)

    G.J. Saulnier Jr; W. Statham

    2006-01-01

    The Nopal I uranium mine in the Sierra Pena Blanca, Chihuahua, Mexico serves as a natural analogue to the Yucca Mountain repository. The Pena Blanca Natural Analogue Performance Assessment Model simulates the mobilization and transport of radionuclides that are released from the mine and transported to the saturated zone. the Pena Blanca Natural Analogue Model uses probabilistic simulations of hydrogeologic processes that are analogous to the processes that occur at the Yucca Mountain site. The Nopal I uranium deposit lies in fractured, welded, and altered rhyolitic ash flow tuffs that overlie carbonate rocks, a setting analogous to the geologic formations at the Yucca Mountain site. The Nopal I mine site has the following characteristics as compared to the Yucca Mountain repository site. (1) Analogous source: UO 2 uranium ore deposit = spent nuclear fuel in the repository; (2) Analogous geologic setting: fractured, welded, and altered rhyolitic ash flow tuffs overlying carbonate rocks; (3) Analogous climate: Semiarid to arid; (4) Analogous geochemistry: Oxidizing conditions; and (5) Analogous hydrogeology: The ore deposit lies in the unsaturated zone above the water table. The Nopal I deposit is approximately 8 ± 0.5 million years old and has been exposed to oxidizing conditions during the last 3.2 to 3.4 million years. The Pena Blanca Natural Analogue Model considers that the uranium oxide and uranium silicates in the ore deposit were originally analogous to uranium-oxide spent nuclear fuel. The Pena Blanca site has been characterized using field and laboratory investigations of its fault and fracture distribution, mineralogy, fracture fillings, seepage into the mine adits, regional hydrology, and mineralization that shows the extent of radionuclide migration. Three boreholes were drilled at the Nopal I mine site in 2003 and these boreholes have provided samples for lithologic characterization, water-level measurements, and water samples for laboratory analysis

  3. THE PENA BLANCA NATURAL ANALOGUE PERFORMANCE ASSESSMENT MODEL

    Energy Technology Data Exchange (ETDEWEB)

    G.J. Saulnier Jr; W. Statham

    2006-03-10

    The Nopal I uranium mine in the Sierra Pena Blanca, Chihuahua, Mexico serves as a natural analogue to the Yucca Mountain repository. The Pena Blanca Natural Analogue Performance Assessment Model simulates the mobilization and transport of radionuclides that are released from the mine and transported to the saturated zone. the Pena Blanca Natural Analogue Model uses probabilistic simulations of hydrogeologic processes that are analogous to the processes that occur at the Yucca Mountain site. The Nopal I uranium deposit lies in fractured, welded, and altered rhyolitic ash flow tuffs that overlie carbonate rocks, a setting analogous to the geologic formations at the Yucca Mountain site. The Nopal I mine site has the following characteristics as compared to the Yucca Mountain repository site. (1) Analogous source: UO{sub 2} uranium ore deposit = spent nuclear fuel in the repository; (2) Analogous geologic setting: fractured, welded, and altered rhyolitic ash flow tuffs overlying carbonate rocks; (3) Analogous climate: Semiarid to arid; (4) Analogous geochemistry: Oxidizing conditions; and (5) Analogous hydrogeology: The ore deposit lies in the unsaturated zone above the water table. The Nopal I deposit is approximately 8 {+-} 0.5 million years old and has been exposed to oxidizing conditions during the last 3.2 to 3.4 million years. The Pena Blanca Natural Analogue Model considers that the uranium oxide and uranium silicates in the ore deposit were originally analogous to uranium-oxide spent nuclear fuel. The Pena Blanca site has been characterized using field and laboratory investigations of its fault and fracture distribution, mineralogy, fracture fillings, seepage into the mine adits, regional hydrology, and mineralization that shows the extent of radionuclide migration. Three boreholes were drilled at the Nopal I mine site in 2003 and these boreholes have provided samples for lithologic characterization, water-level measurements, and water samples for laboratory

  4. ETUDE DE LA DISTRIBUTION DES CATIONS ECHANGEABLES

    African Journals Online (AJOL)

    SEI Joseph

    ces formations, la nature des phases minérales, les différentes phases de métamorphisme ayant affecté les corps minéralisés et les roches encaissantes, ainsi qu'une mise en évidence des différentes paragenèses entrant dans la composition des corps minéralisés [2,3]. Dans cette note, nous proposons la discussion de.

  5. Parasitisme des loranthaceae et association culturale en ...

    African Journals Online (AJOL)

    Cependant, quelques exceptions existent, liées notamment à la présence des arbres qui leur sont associés et qui sont densément parasités avec un degré moyen d'infestation de 32,65 p.c. et de 14,04 touffes/plante. Hevea brasiliensis, Mangifera indica et Myrianthus arboreus ont été épargnées des attaques des ...

  6. Developpement des systemes de production innovants d ...

    African Journals Online (AJOL)

    Pourtant, les associations maïs/légumineuses ont l'avantage d'améliorer la production et l'alimentation animale. Elles représentent une alternative dans la gestion des risques et des incertitudes pour les agro-éleveurs, confrontés aux changements globaux (climatiques, pression foncière, dégradation des ressources ...

  7. (TEC) et ciblage des pauvres au Mali

    International Development Research Centre (IDRC) Digital Library (Canada)

    Comment est-ce que c'est vrai. La preuve par … □ Différentiel de ciblage entre P et NP. □ Part normalisée de consommation/achat des Pauvres. □ Part normalisée de la pression fiscale. (totale et de porte) sur les achats des P. □ Part normalisée des "exonérations" revenant aux Pauvres ...

  8. La Gestion des Déchets Urbains

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le Service d'inspection des installations classées évolue actuellement en conformité avec les règlements français de 1926 régissant les établissements malsains, dérangeants ou dangereux. En effet, la loi ivoirienne, adoptée à la hâte en 1988 pendant la crise du transport des déchets radioactifs en provenance des pays ...

  9. Adaptation des organismes communautaires d'approvisionnement ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Les villes connaissent également une croissance rapide, ce qui augmente la demande en eau. Ces changements réduisent la capacité des organismes communautaires à combler la demande en eau potable, la stabilité des sources d'eau étant menacée. Ce projet de recherche vise à étudier les effets des changements ...

  10. Contamination des eaux souterraines par le lixiviat des décharges ...

    African Journals Online (AJOL)

    La percolation du lixiviat en provenance des dechets des decharges constitue une source de pollution des ressources en eau souterraine par infiltration, constituant ainsi une menace aussi importante que celle liee a l'accentuation du deficit hydrique. La decharge publique de Larache constitue un modele type de ...

  11. Contribution des TICs à l'abandon des mutilations génitales ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Contribution des TIC à l'abandon des MGF en Afrique de l'Ouest francophone : rôle des jeunes citoyennes; rapport technique no. 5 (rapport technique final), 18 octobre 2008 - 31 mars 2009. Download PDF. Related content. New website will help record vital life events to improve access to services for all. A new website ...

  12. Etat des lieux de la gestion des insecticides au Togo, Afrique de l ...

    African Journals Online (AJOL)

    Pour parvenir à une gestion optimale des maladies à transmission vectorielle ou tout au moins la nuisance culicidienne, une surveillance permanente des facteurs de risque devient nécessaire. Le principal facteur de risque est le vecteur qui transmet la maladie, et le contrôle du vecteur passe par des stratégies de lutte qui ...

  13. Qualité microbiologique des eaux des fleuves Nyong et Wouri ...

    African Journals Online (AJOL)

    Qualité microbiologique des eaux des fleuves Nyong et Wouri (Cameroun) et impact potentiel sur la santé des populations riveraines. Larissa Abologo Azeme, Claudine Mireille Ntsama Essomba, Lucie Leme Banock, Charles Félix Bilong Bilong ...

  14. Evaluation de l\\'activité hémagglutinante des lectines des graines de ...

    African Journals Online (AJOL)

    % de saturation, de l\\'extrait brut de Csp présente l\\'activité hémagglutinante la plus élevée (512). Le traitement thermique à 100°C pendant 15 minutes réduit significativement l\\'activité hémagglutinante des lectines des extraits bruts des graines ...

  15. Association des universités africaines - section des TIC pour les ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Association des universités africaines - section des TIC pour les réseaux nationaux de recherche et d'éducation. L'Association ... Africa's New Frontier : Innovation. Technology. ... L'Initiative des conseils subventionnaires de la recherche scientifique en Afrique subsaharienne remporte le prix de la diplomatie scientifique.

  16. Emploi des jeunes et autonomisation économique des femmes en ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Emploi des jeunes et autonomisation économique des femmes en Afrique : le rôle des petites et moyennes entreprises dans le secteur du tourisme ... le secteur du tourisme menées par les gouvernements et leurs partenaires, participera à la formulation de recommandations stratégiques fiables, et renforcera les capacités ...

  17. Vivre et survivre au bord des villes

    Directory of Open Access Journals (Sweden)

    Michel Péraldi

    1996-04-01

    Full Text Available De quels revenus vivent, ou plutôt survivent, les populations des quartiers dits défavorisés ? Telle est, malgré son apparente banalité, la question qui initie aujourd'hui une partie de nos recherches. Question banale en effet puisque les médias et le débat politique nous donnent une réponse sans appel, statistiquement fiable : dans ces univers sociaux où se croisent des communautés issues des plus récentes migrations et les fractions les plus fragiles économiquement des classes populaires fr...

  18. Modalites de consommation et valeur nutritionnelle des ...

    African Journals Online (AJOL)

    Les légumineuses niébé, voandzou et zamnè sont consommées sous forme de ragout et de plats associés à des céréales respectivement par 99%, 93% et 76%. L'arachide et le soja sont utilisés comme des ingrédients ou comme des collations. Les légumineuses ont des teneurs importantes en protéines, 35,76%, 31,04%, ...

  19. Fusion des bourses : analyse de cas

    OpenAIRE

    Frunz, Dylan; Tuchschmid, Nils

    2013-01-01

    Dans le cadre de mon travail de Bachelor, je vais tenter de déterminer les raisons et conséquences des importantes fusions actuelles entre bourses historiques mondiales. Les bourses, représentées par leurs différents indices, représentent le niveau actuel de l’économie des pays par le biais des nombreuses sociétés y étant cotées. Le regroupement des activités entre bourses traditionnelles s’est dessiné avec pour objectif de contrer la nouvelle concurrence, apparue suite à la nouvelle directiv...

  20. Liste des abréviations

    OpenAIRE

    2014-01-01

    AI : Amnesty International CADH : Convention américaine des droits de l'homme CEDH : Commission européenne des droits de l'homme CIDH : Commission interaméricaine des droits de l'homme CIJ : Cour internationale de Justice ECOSOC : Economic and Social Council (UN) IACHR : Inter-American Commission on Human Rights IIJ :Instituto de Investigaciones Jurídicas (UNAM) IIDH : Instituto Interamericano de Derechos Humanos LGDJ : Librairie générale de droit et de jurisprudence OEA : Organisation des Ét...

  1. Évaluation de la valeur nutritive et recherche des substances ...

    African Journals Online (AJOL)

    Puis, l'évaluation a été effectuée sur ces échantillons pour rechercher la présence des alcaloïdes, des saponines, des quinones, des stéroïdes, des terpenoïdes, des flavonoïdes, des leucoanthocyanes, des tannoïdes et des hétérosides cyanogénétiques. Les teneurs moyennes en humidité, en cendres, en protéines, en ...

  2. EFFET DES TRAITEMENTS THERMIQUES SUR LA REACTION ENTRE DES COUCHES MINCES DE TITANE ET DES SUBSTRATS EN ACIER

    Directory of Open Access Journals (Sweden)

    D Slimani

    2015-06-01

    Full Text Available Des couches minces du titane pur ont été déposées avec la méthode de pulvérisation cathodique sur des substrats en acier, type FF80 K-1 contenants ~1% mass. en carbone. La réaction entre les deux parties du système substrat-couche mince est activée avec des traitements thermiques sous vide dans l’intervalle de températures de 400 à900°Cpendant 30 minutes. Les Spectres de diffraction de rayons x confirment l’inter- diffusion des éléments  chimiques du système résultants la formation et la croissance des nouvelles phases en particulier le carbure binaire TiC ayant des caractéristiques thermomécaniques importantes. L’analyse morphologique des échantillons traités  avec le microscope électronique à balayage (MEB montre l’augmentation du flux de diffusion atomique avec la température de recuit, notamment la diffusion du manganèse et du fer vers la surface libre des échantillons aux températures élevées provoquant la dégradation des propriétés mécaniques des revêtements contrairement au premiers stades d’interaction où on a obtenu des bonnes valeurs de la microdureté.

  3. Influence des tanins sur la valeur nutritive des aliments des ruminants

    OpenAIRE

    Zimmer, N.; Cordesse, R.

    1996-01-01

    Les tanins sont des métabolites secondaires importants dans le règne végétal. Ils s’intègrent dans la défense des végétaux contre les herbivores, en particulier pour les plantes se développant dans les zones difficiles. La structure chimique de ces polyphénols leur confère une capacité très développée à se fixer sur toutes sortes de molécules, essentiellement les protéines. Ces interactions faisant intervenir les différents types de liaison possibles sont dépendantes de nombreux facteurs liés...

  4. Examen des politiques de STI au Mozambique | IDRC - International ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Ce projet vise à renforcer les capacités du ministère des Sciences et de la Technologie du Mozambique de gouverner le système de science, de technologie et d'innovation (STI) du pays, et celles des chercheurs et des responsables des politiques d'effectuer des examens systématiques de la mise en oeuvre des ...

  5. Examen des politiques de STI au Mozambique | CRDI - Centre de ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Ce projet vise à renforcer les capacités du ministère des Sciences et de la Technologie du Mozambique de gouverner le système de science, de technologie et d'innovation (STI) du pays, et celles des chercheurs et des responsables des politiques d'effectuer des examens systématiques de la mise en oeuvre des ...

  6. Surmonter les obstacles à l'adoption des lignes directrices ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Des études portant sur l'éducation communautaire et des évaluations du contexte de la vente au détail à l'échelon local viendront compléter des études des politiques nationales relatives à l'étiquetage des aliments, à la réduction de la consommation de sel et de sucre, au prix des aliments et à la commercialisation.

  7. More Intelligent Gas Turbine Engines (Des turbomoteurs plus intelligents)

    Science.gov (United States)

    2009-04-01

    généralisé, aux diagnostics et aux pronostics évolués intégrés dans des commandes moteurs intelligentes ainsi que du contrôle distribué avec des capteurs et...des servomoteurs intelligents. Ce rapport met l’accent sur l’identification des besoins en capteurs et en servomoteurs, des technologies actuelles...sur les capteurs et les servomoteurs et des feuilles de route pour les technologies émergeantes du point de vue des performances des turbines à gaz

  8. Impact de la preparation des anodes crues et des conditions de cuisson sur la fissuration dans des anodes denses

    Science.gov (United States)

    Amrani, Salah

    La fabrication de l'aluminium est realisee dans une cellule d'electrolyse, et cette operation utilise des anodes en carbone. L'evaluation de la qualite de ces anodes reste indispensable avant leur utilisation. La presence des fissures dans les anodes provoque une perturbation du procede l'electrolyse et une diminution de sa performance. Ce projet a ete entrepris pour determiner l'impact des differents parametres de procedes de fabrication des anodes sur la fissuration des anodes denses. Ces parametres incluent ceux de la fabrication des anodes crues, des proprietes des matieres premieres et de la cuisson. Une recherche bibliographique a ete effectuee sur tous les aspects de la fissuration des anodes en carbone pour compiler les travaux anterieurs. Une methodologie detaillee a ete mise au point pour faciliter le deroulement des travaux et atteindre les objectifs vises. La majorite de ce document est reservee pour la discussion des resultats obtenus au laboratoire de l'UQAC et au niveau industriel. Concernant les etudes realisees a l'UQAC, une partie des travaux experimentaux est reservee a la recherche des differents mecanismes de fissuration dans les anodes denses utilisees dans l'industrie d'aluminium. L'approche etait d'abord basee sur la caracterisation qualitative du mecanisme de la fissuration en surface et en profondeur. Puis, une caracterisation quantitative a ete realisee pour la determination de la distribution de la largeur de la fissure sur toute sa longueur, ainsi que le pourcentage de sa surface par rapport a la surface totale de l'echantillon. Cette etude a ete realisee par le biais de la technique d'analyse d'image utilisee pour caracteriser la fissuration d'un echantillon d'anode cuite. L'analyse surfacique et en profondeur de cet echantillon a permis de voir clairement la formation des fissures sur une grande partie de la surface analysee. L'autre partie des travaux est basee sur la caracterisation des defauts dans des echantillons d'anodes crues

  9. Développer le leadership dans des villes de l'Amérique latine et des ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Développer le leadership dans des villes de l'Amérique latine et des Caraïbes dans le contexte des changements climatiques. En raison des changements climatiques, de la croissance démographique et de l'urbanisation rapide non planifiée, les villes des pays en développement sont à la fois le principal déclencheur des ...

  10. Using XML to encode TMA DES metadata.

    Science.gov (United States)

    Lyttleton, Oliver; Wright, Alexander; Treanor, Darren; Lewis, Paul

    2011-01-01

    The Tissue Microarray Data Exchange Specification (TMA DES) is an XML specification for encoding TMA experiment data. While TMA DES data is encoded in XML, the files that describe its syntax, structure, and semantics are not. The DTD format is used to describe the syntax and structure of TMA DES, and the ISO 11179 format is used to define the semantics of TMA DES. However, XML Schema can be used in place of DTDs, and another XML encoded format, RDF, can be used in place of ISO 11179. Encoding all TMA DES data and metadata in XML would simplify the development and usage of programs which validate and parse TMA DES data. XML Schema has advantages over DTDs such as support for data types, and a more powerful means of specifying constraints on data values. An advantage of RDF encoded in XML over ISO 11179 is that XML defines rules for encoding data, whereas ISO 11179 does not. We created an XML Schema version of the TMA DES DTD. We wrote a program that converted ISO 11179 definitions to RDF encoded in XML, and used it to convert the TMA DES ISO 11179 definitions to RDF. We validated a sample TMA DES XML file that was supplied with the publication that originally specified TMA DES using our XML Schema. We successfully validated the RDF produced by our ISO 11179 converter with the W3C RDF validation service. All TMA DES data could be encoded using XML, which simplifies its processing. XML Schema allows datatypes and valid value ranges to be specified for CDEs, which enables a wider range of error checking to be performed using XML Schemas than could be performed using DTDs.

  11. Using XML to encode TMA DES metadata

    Directory of Open Access Journals (Sweden)

    Oliver Lyttleton

    2011-01-01

    Full Text Available Background: The Tissue Microarray Data Exchange Specification (TMA DES is an XML specification for encoding TMA experiment data. While TMA DES data is encoded in XML, the files that describe its syntax, structure, and semantics are not. The DTD format is used to describe the syntax and structure of TMA DES, and the ISO 11179 format is used to define the semantics of TMA DES. However, XML Schema can be used in place of DTDs, and another XML encoded format, RDF, can be used in place of ISO 11179. Encoding all TMA DES data and metadata in XML would simplify the development and usage of programs which validate and parse TMA DES data. XML Schema has advantages over DTDs such as support for data types, and a more powerful means of specifying constraints on data values. An advantage of RDF encoded in XML over ISO 11179 is that XML defines rules for encoding data, whereas ISO 11179 does not. Materials and Methods: We created an XML Schema version of the TMA DES DTD. We wrote a program that converted ISO 11179 definitions to RDF encoded in XML, and used it to convert the TMA DES ISO 11179 definitions to RDF. Results: We validated a sample TMA DES XML file that was supplied with the publication that originally specified TMA DES using our XML Schema. We successfully validated the RDF produced by our ISO 11179 converter with the W3C RDF validation service. Conclusions: All TMA DES data could be encoded using XML, which simplifies its processing. XML Schema allows datatypes and valid value ranges to be specified for CDEs, which enables a wider range of error checking to be performed using XML Schemas than could be performed using DTDs.

  12. Dynamique des populations du foreur des tiges du cacaoyer ...

    African Journals Online (AJOL)

    SARAH

    30 nov. 2014 ... déprédateur dans la région du Haut-Sassandra, la deuxième plus grande région de production de cacao en. Côte d'ivoire. Méthodologie et résultats : L'étude a été réalisée de 2009 à 2013 dans les plantations villageoises de la région du Haut-Sassandra en Côte d'Ivoire. Les variations des taux d'attaques ...

  13. Dynamique des peuplements des Parcelles d'Essais Sylvicoles (PES)

    African Journals Online (AJOL)

    Le traitement To (sans traitement) et T2 T1 (simple Coppice) ont été appliqués. De plus, des données historiques sur l'évolution de PFTP depuis 1996 ont été considérées. Un total de 09 espèces regroupées en 05 familles ont été identifiées. Les Fabaceae forment le fonds floristique. La formation est une savane arbustive, ...

  14. Quantum Analogues: From Phase Transitions to Black Holes and Cosmology

    International Nuclear Information System (INIS)

    Liberati, Stefano

    2008-01-01

    'And I cherish more than anything else the analogies, my most trustworthy masters. They know all the secrets of nature, and they ought to be least neglected in geometry.' These words of the great astronomer Johannes Kepler embody the philosophy behind the research recounted in this interesting book-a book composed of nine selected lectures (and a nice introduction by Bill Unruh) from the international workshop on 'Quantum Simulations via Analogues', which was held in the Max Planck Institute for the Physics of Complex Systems in Dresden during the summer of 2005. Analogue models of (and for) gravity have a long and distinguished history dating back to the earliest years of general relativity. However the last decade has seen a remarkable and steady development of analogue gravity models based on condensed matter systems, leading to some hundreds of published articles, numerous workshops, and several books. While the main driver for this booming field has definitely been the puzzling physics associated with quantum effects in black holes, more recently much attention has also been devoted to other interesting issues-such as cosmological particle production or the cosmological constant problem. Moreover, together with these new themes there has been a persistent interest in the possibility of simulating cosmic topological defects in the laboratory (although it should be said that momentum for this line of research has been somewhat weakened by the progressive decrease of interest in cosmological topological defects as an alternative to inflationary scenarios). All these aspects are faithfully accounted for in this book, which does a good job at presenting a vivid snapshot of many (if not quite all) of the most interesting lines of research in the field. All the articles have a self-consistent structure-which allows one to read them in arbitrary order and appreciate the full richness of each topic. However, when considered together I would say that they also provide a

  15. Quantitative comparisons of analogue models of brittle wedge dynamics

    Science.gov (United States)

    Schreurs, Guido

    2010-05-01

    Analogue model experiments are widely used to gain insights into the evolution of geological structures. In this study, we present a direct comparison of experimental results of 14 analogue modelling laboratories using prescribed set-ups. A quantitative analysis of the results will document the variability among models and will allow an appraisal of reproducibility and limits of interpretation. This has direct implications for comparisons between structures in analogue models and natural field examples. All laboratories used the same frictional analogue materials (quartz and corundum sand) and prescribed model-building techniques (sieving and levelling). Although each laboratory used its own experimental apparatus, the same type of self-adhesive foil was used to cover the base and all the walls of the experimental apparatus in order to guarantee identical boundary conditions (i.e. identical shear stresses at the base and walls). Three experimental set-ups using only brittle frictional materials were examined. In each of the three set-ups the model was shortened by a vertical wall, which moved with respect to the fixed base and the three remaining sidewalls. The minimum width of the model (dimension parallel to mobile wall) was also prescribed. In the first experimental set-up, a quartz sand wedge with a surface slope of ˜20° was pushed by a mobile wall. All models conformed to the critical taper theory, maintained a stable surface slope and did not show internal deformation. In the next two experimental set-ups, a horizontal sand pack consisting of alternating quartz sand and corundum sand layers was shortened from one side by the mobile wall. In one of the set-ups a thin rigid sheet covered part of the model base and was attached to the mobile wall (i.e. a basal velocity discontinuity distant from the mobile wall). In the other set-up a basal rigid sheet was absent and the basal velocity discontinuity was located at the mobile wall. In both types of experiments

  16. Incertitude sur l'analyse des contraintes par diffraction des rayons X

    OpenAIRE

    Kahloun , C.; Badawi , K.F.; Diou , A.

    1990-01-01

    Dans cette étude, nous avons développé une méthode d'estimation de la valeur des erreurs de mesure commises lors de l'analyse des contraintes par diffraction des rayons X. Nous avons vérifié à partir de cinquante déterminations des contraintes le non-biais des estimateurs proposés, ainsi que toutes les hypothèses faites pour établir ces estimateurs. Nous avons également établi un critère de choix du nombre et des valeurs des angles d'incidence ψ en fonction de la précision de mesure souhaitée...

  17. Migrastatin analogues inhibit canine mammary cancer cell migration and invasion.

    Directory of Open Access Journals (Sweden)

    Kinga Majchrzak

    Full Text Available BACKGROUND: Cancer spread to other organs is the main cause of death of oncological patients. Migration of cancer cells from a primary tumour is the crucial step in the complex process of metastasis, therefore blocking this process is currently the main treatment strategy. Metastasis inhibitors derived from natural products, such as, migrastatin, are very promising anticancer agents. Thus, the aim of our study was to investigate the effect of six migrastatin analogues (MGSTA-1 to 6 on migration and invasion of canine mammary adenocarcinoma cell lines isolated from primary tumours and their metastases to the lungs. Canine mammary tumours constitute a valuable tool for studying multiple aspect of human cancer. RESULTS: OUR RESULTS SHOWED THAT TWO OF SIX FULLY SYNTHETIC ANALOGUES OF MIGRASTATIN: MGSTA-5 and MGSTA-6 were potent inhibitors of canine mammary cancer cells migration and invasion. These data were obtained using the wound healing test, as well as trans-well migration and invasion assays. Furthermore, the treatment of cancer cells with the most effective compound (MGSTA-6 disturbed binding between filamentous F-actin and fascin1. Confocal microscopy analyses revealed that treatment with MGSTA-6 increased the presence of unbound fascin1 and reduced co-localization of F-actin and fascin1 in canine cancer cells. Most likely, actin filaments were not cross-linked by fascin1 and did not generate the typical filopodial architecture of actin filaments in response to the activity of MGSTA-6. Thus, administration of MGSTA-6 results in decreased formation of filopodia protrusions and stress fibres in canine mammary cancer cells, causing inhibition of cancer migration and invasion. CONCLUSION: Two synthetic migrastatin analogues (MGSTA-5 and MGSTA-6 were shown to be promising compounds for inhibition of cancer metastasis. They may have beneficial therapeutic effects in cancer therapy in dogs, especially in combination with other anticancer drugs

  18. Alligator Rivers Analogue Project. Final Report - Volume 1

    International Nuclear Information System (INIS)

    Duerden, P.; Lever, D.A.; Sverjensky, D.A.; Townley, L.R.

    1992-01-01

    This summary report, which highlights the work and findings of the Alligator Rivers Analogue Project (ARAP) is one of a series of 16 volumes, listed below. Detailed descriptions and results are provided in Volumes 2 to 16. Full acknowledgment to individual contributions is provided in the individual reports, and in Appendix I of this report. The findings from the technical studies are discussed in the context of assessments of the long-term performance of geological repositories for radioactive wastes, which are being undertaken in many countries. They are also considered in an integrated 'Scenario Development' approach, aimed to understand the formation of the ore deposit. Despite their inherent uncertainties, the findings provide a basis for assessing the way in which radionuclides will migrate in environments with a variety of geologic settings and over a range of different geologic timescales. Thus, section 2 of this report discusses the concept of using uranium deposits as natural analogues and refers to a number of such studies, including those at the Koongarra deposit in the Alligator Rivers Region of the Northern Territory of Australia. Section 3 reviews early scientific work in the Alligator Rivers Region and summarises the results of the analogue studies undertaken between 1981 and 1987 that were funded by the US Nuclear Regulatory Commission (USNRC) and the UK Department of the Environment (UKDoE). Section 4 describes the objectives of ARAP and the manner in which the study was conducted and provides a general outline of the project and a summary of the findings. A general description of the Koongarra ore deposit, the focus of ARAP, is provided in Section 5, with Sections 6-13 providing summaries of the work carried out to characterise the site in detail and provide data for modelling. Sections 14-18 discuss how this data was used in modelling and how the results may be applied for performance assessment studies. Finally, Section 19 considers the

  19. Pena Blanca Natural Analogue Project: Summary of activities

    Energy Technology Data Exchange (ETDEWEB)

    Levy, S.; Goldstein, S.; Dobson, P.F.; Goodell, P.; Ku, T.-L.; Abdel-Fattah, A.; Saulnier, G.; Fayek, M.; de la Garza, R.

    2011-02-01

    The inactive Nopal I uranium mine in silicic tuff north of Chihuahua City, Chihuahua, Mexico, was studied as a natural analogue for an underground nuclear-waste repository in the unsaturated zone. Site stratigraphy was confirmed from new drill cores. Data from site studies include chemical and isotopic compositions of saturated- and unsaturated-zone waters. A partial geochronology of uranium enrichment and mineralization was established. Evidence pertinent to uranium-series transport in the soil zone and changing redox conditions was collected. The investigations contributed to preliminary, scoping-level performance assessment modeling.

  20. Application of FPGA's in Flexible Analogue Electronic Image Generator Design

    Directory of Open Access Journals (Sweden)

    Peter Kulla

    2006-01-01

    Full Text Available This paper focuses on usage of the FPGAs (Field Programmable Gate Arrays Xilinx as a part of our more complex workdedicated to design of flexible analogue electronic images generator for application in TV measurement technique or/and TV servicetechnique or/and education process. The FPGAs performs here the role of component colour R, G, B, synchronization and blanking signals source. These signals are next processed and amplified in other parts of the generator as NTSC/PAL source encoder and RF modulator. The main aim of this paper is to show the possibilities how with suitable development software use a FPGAs in analog TV technology.

  1. Captopril analogues as metallo-β-lactamase inhibitors.

    Science.gov (United States)

    Yusof, Yusralina; Tan, Daniel T C; Arjomandi, Omid Khalili; Schenk, Gerhard; McGeary, Ross P

    2016-03-15

    A number of captopril analogues were synthesised and tested as inhibitors of the metallo-β-lactamase IMP-1. Structure-activity studies showed that the methyl group was unimportant for activity, and that the potencies of these inhibitors could be best improved by shortening the length of the mercaptoalkanoyl side-chain. Replacing the thiol group with a carboxylic acid led to complete loss of activity, and extending the length of the carboxylate group led to decreased potency. Good activity could be maintained by substituting the proline ring with pipecolic acid. Copyright © 2016 Elsevier Ltd. All rights reserved.

  2. Synthesis, Preliminary Bioevaluation and Computational Analysis of Caffeic Acid Analogues

    Directory of Open Access Journals (Sweden)

    Zhiqian Liu

    2014-05-01

    Full Text Available A series of caffeic acid amides were designed, synthesized and evaluated for anti-inflammatory activity. Most of them exhibited promising anti-inflammatory activity against nitric oxide (NO generation in murine macrophage RAW264.7 cells. A 3D pharmacophore model was created based on the biological results for further structural optimization. Moreover, predication of the potential targets was also carried out by the PharmMapper server. These amide analogues represent a promising class of anti-inflammatory scaffold for further exploration and target identification.

  3. Optical analogues of nanostructures with Rashba–Dresselhaus interactions

    International Nuclear Information System (INIS)

    Dragoman, Daniela

    2014-01-01

    We demonstrate that light propagation through uniaxial crystals with suitably oriented optical axes is quantitatively analogous to electron propagation in a two-dimensional electron gas in the presence of Rashba and/or Dresselhaus effects. It is shown that, through an appropriate shaping of light beams and a rigorous control of their incidence angle on properly oriented uniaxial crystals, it is possible to investigate independently the effects of angular divergence and energy broadening on electron wavefunction evolution. Such optical analogues could be useful in designing spintronic devices, in particular those relying on the equality of Rashba and Dresselhaus coefficients. (paper)

  4. A high speed digital-to-analogue converter

    International Nuclear Information System (INIS)

    Hallgren, B.I.

    1974-02-01

    An 8-bit Digital-to-Analogue converter of the current-weighting type has been constructed using 8 monolithic integrated circuit transistor arrays -one for each bit. The D/A-converter has a voltage output within the range 0 to -2V. The settling time to within half of the least significant bit is about 50 nsec. The temperature dependence and transient response of the converter has been analysed using computer aided design techniques. A comparison is made between the experimental and simulated transient performance. (Auth.)

  5. Pena blanca natural analogue project: summary of activities

    Energy Technology Data Exchange (ETDEWEB)

    Levy, Schon S [Los Alamos National Laboratory; Goldstein, Steven J [Los Alamos National Laboratory; Abdel - Fattah, Amr I [Los Alamos National Laboratory

    2010-12-08

    The inactive Nopal I uranium mine in silicic tuff north of Chihuahua City, Chihuahua, Mexico, was studied as a natural analogue for an underground nuclear-waste repository in the unsaturated zone. Site stratigraphy was confirmed from new drill core. Datafrom site studies include chemical and isotopic compositions of saturated- and unsaturated-zone waters. A partial geochronology of uranium enrichment and mineralization was established. Evidence pertinent to uranium-series transport in the soil zone and changing redox conditions was collected. The investigations contributed to preliminary, scoping-level performance assessment modeling.

  6. Isosteric phosphonate pyrrolidine-based dinucleoside monophosphate analogues

    Czech Academy of Sciences Publication Activity Database

    Vaněk, Václav; Buděšínský, Miloš; Kavenová, Ivana; Rinnová, Markéta; Rosenberg, Ivan

    2003-01-01

    Roč. 22, 5/8 (2003), s. 1065-1067 ISSN 1525-7770. [International Roundtable Nucleosides, Nucleotides and Nucleic Acids /15./. Leuven, 10.09.2002-14.09.2002] R&D Projects: GA ČR GA203/01/1166; GA AV ČR IAA4055101 Institutional research plan: CEZ:AV0Z4055905 Keywords : pyrrolidine-based phosphonate nucleotides * ApA analogues * triplex Subject RIV: CC - Organic Chemistry Impact factor: 0.813, year: 2003

  7. Mammary analogue secretory carcinoma: A rare salivary gland tumour

    Directory of Open Access Journals (Sweden)

    B S Jackson

    2017-04-01

    Full Text Available Mammary analogue secretory carcinoma (MASC is a rare and recently described tumour of the salivary glands. MASC has similar histomorphological and immunohistochemical features of secretory carcinoma of the breast. MASC can be mistaken for other salivary gland tumours, especially acinic cell carcinoma. A 28-year-old man was diagnosed with a rare salivary gland tumour in Pretoria, South Africa (SA. To our knowledge, a report of MASC in SA has not previously been published. The surgeons dealing with salivary gland tumours should be aware of the clinical presentation. Current treatment is similar to that of other salivary gland malignancies.

  8. Are Structural Analogues to Bisphenol A Safe Alternatives?

    DEFF Research Database (Denmark)

    Rosenmai, Anna Kjerstine; Dybdahl, Marianne; Pedersen, Mikael

    2014-01-01

    Background: Bisphenol A (BPA) is a chemical with widespread human exposure suspected of causing low-dose effects. Thus, a need for developing alternatives to BPA exists. Structural analogues of BPA have already been detected in foods and humans. Due to the structural analogy of the alternatives......, there is a risk of effects similar to BPA.Objectives: The aim was to elucidate and compare the hazards of bisphenol B (BPB), bisphenol E (BPE), bisphenol F (BPF), bisphenol S (BPS) and 4-cumylphenol (HPP) to BPA.Methods: In vitro studies on steroidogenesis, receptor activity, and biomarkers of effect, as well...

  9. Synthesis of Analogues of Thyroid Hormones: Nuclear Receptor Modulators

    Directory of Open Access Journals (Sweden)

    Guilherme Vieira de Castro

    2015-09-01

    Full Text Available Thyroid hormones are essential for the development and differentiation of all cells of the human body. This work reports the synthesis of some synthetic structural analogues of thyroid hormones, which may be modulators of the thyroid hormone receptor. The known compounds GC-1 (Sobetirome and CG-24 were successfully prepared and two novel analogous molecules were also synthesized by a new and efficient synthetic methodology. DOI: http://dx.doi.org/10.17807/orbital.v7i3.739  

  10. Tidal regimes and salt marshes - the River Hamble analogue

    International Nuclear Information System (INIS)

    Gray, A.J.; Moy, I.L.; Warman, E.A.; Dawson, F.H.; Henville, P.

    1993-01-01

    Construction of estuarine tidal-energy barrages has a potentially major effect on the tidal regime of the estuary, particularly upstream of a barrage. Because tidal regime largely controls the distribution and species composition of intertidal plant and animal communities, it is important to understand how barrages may affect such communities. The main objectives of the research described in this report were to relate recent changes in tidal regime within an embanked area of salt marsh and mudflat to changes in the distribution of plant species. This was to test predictions about tidal control of species' range and to assess the site's suitability as an analogue of post-barrage conditions. (author)

  11. Complications du traitement traditionnel des fractures : aspects ...

    African Journals Online (AJOL)

    Ces pratiques sont aussi vieilles que le monde. L'objectif principal de ce travail était d'abord de montrer la fréquence et ... La médecine traditionnelle comme la médecine moderne comporte toujours des marges d'erreurs pouvant conduire à des complications. Les tradipraticiens disposent de connaissances approximatives ...

  12. ETUDE DE LA DISTRIBUTION DES CATIONS ECHANGEABLES

    African Journals Online (AJOL)

    SEI Joseph

    objectif de cette étude est d'avoir des données préliminaires sur la croissance et la production de ce cultivar de niébé en rapport avec les conditions pédoclimatiques de la zone. Le pouvoir germinatif des graines a été évalué, avant le semis et.

  13. 1 | Page PROSPECTUS INITIATIVE DES CONSEILS ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    khaled fourati

    recherche par les gouvernements nationaux, l'accroissement des activités de production et d'innovation scientifiques, la création d'organisations de soutien à la recherche scientifique, à la technologie et à l'innovation, et l'augmentation des projets de recherche coopératifs interrégionaux. Par exemple, de nombreux.

  14. internationalisation et nouvelles implantations des firmes

    African Journals Online (AJOL)

    Administrateur

    implantation des firmes multinationales ainsi que des nombreuses extensions possibles du modèle. ... Docteur en science de gestion, Chercheur en stratégie et prospective. ..... firme dans ses choix de filiales et de métiers à intégrer dans la phase.

  15. Differntiation genetique des populations geographiques de ...

    African Journals Online (AJOL)

    Differntiation genetique des populations geographiques de Colletotrichum kahawae, agent pathogene responsable de l\\'anthracnose des baies du cafeier Arabica. B Manga, J V Fabre, D Bieysse, J A Mouen Bedimo, C Herail, D Berry. Abstract. No Abstract. Cameroon Journal of Agricultural Science Vol. 1 (2) 2005 pp.

  16. Mycotrophie Et Connaissances Paysannes Des Essences ...

    African Journals Online (AJOL)

    Dacryodes edulis, Elaesis guineensis, Citrus sinensis, Citrus reticulata, Mangifera indica et Persea americana sont plus fréquentes dans les deux sites. La classification des paysans des essences fertilitaires est basée sur certains attributs fonctionnels tels que le système racinaire et la surface foliaire. La comparaison entre ...

  17. Schellings Wesensbestimmung des Christentums in den ...

    African Journals Online (AJOL)

    p1243322

    Methodenlehre des akademischen Studiums” an, die von der. Überzeugung geleitet ist, daß eine solche Methodenlehre “nur aus der wirklichen und wahren Erkenntniß des lebendigen Zusammenhangs aller. Wissenschaften hervorgehen könne” (SW V, ...

  18. La tuberculose des amygdales palatines

    Directory of Open Access Journals (Sweden)

    Oudidi Abdelatif

    2010-01-01

    Full Text Available INTRODUCTION:La localisation tuberculeuse des amygdales palatines est très rare même dans un pays d’endémie tuberculeuse. Le diagnostic peut être suspecté cliniquement dans un contexte évocateur, mais il ne peut être certifié qu’au stade histologique. PATIENTS ET METHODES:Cinq cas de tuberculose des amygdales palatine ont été diagnostiqués sur une période de 5 ans et inclus dans une étude rétrospective. Nous avons recensé trois hommes et deux femmes (âge moyen de 28 ans. La dysphagie haute était le maître symptôme. L’examen a objectivé une hypertrophie amygdalienne chez tous les patients avec des ulcérations chez trois d’entre eux. Une biopsie a été effectuée chez trois patients et une amygdalectomie a été réalisée chez les deux autres. L’étude anatomopathologique a posé le diagnostic chez tous les patients. Un traitement médical antituberculeux selon un régime court allant de 6 à 9 mois a été instauré. Dans tous les cas, l’évolution à long terme a été favorable avec un recul moyen de 13 mois. CONCLUSION: La tuberculose amygdalienne est rare. Son diagnostic repose essentiellement sur le résultat anatomopathologique de la biopsie où de l’amygdalectomie. L’évolution sous traitement anti-bacillaire est souvent favorable, la récidive est exceptionnelle.

  19. GENOMIQUE ET LIPIDES Génomique et métabolisme des lipides des plantes

    Directory of Open Access Journals (Sweden)

    Delseny Michel

    2002-03-01

    Full Text Available Il existe dans les bases de données publiques une énorme quantité de séquences d’ADN dérivées de plantes, et notamment la séquence complète du génome d’Arabidopsis thaliana, une plante modèle pour les oléagineux, proche parente du colza. Ces données constituent une ressource importante non seulement pour la compréhension de métabolisme lipidique et de sa régulation, mais aussi pour la sélection et le développement de variétés nouvelles d’oléagineux produisant davantage d’huiles ou des huiles de composition nouvelle. Cette abondance de séquences peut être exploitée, en utilisant les recherches d’homologies, pour identifier les gènes, pour obtenir des informations sur leur fonction, comme pour repérer des gènes candidats codant des fonctions nouvelles. L’analyse de ces bases de données a révélé que la majeure partie des gènes codant des enzymes impliquées dans le métabolisme lipidique appartient à des petites familles multigéniques, reflétant la diversification des fonctions des isoformes. Une analyse du catalogue des ADNc séquencés en aveugle reflète les niveaux d’expression des différents gènes et fournit un aperçu des régulations des flux au travers des voies métaboliques conduisant à la biosynthèse des lipides de réserve. La disponibilité de mutants et de lignées transgéniques d’Arabidopsis et le développement de puces à ADN qui permettent l’analyse simultanée de plusieurs milliers de gènes conduiront à une meilleure compréhension des facteurs qui régulent le métabolisme des huiles dans les graines. Une telle connaissance facilitera la manipulation de la composition des huiles et des quantités produites dans les graines.

  20. The arsonomethyl analogue of adenosine 5'-phosphate. An uncoupler of adenylate kinase.

    Science.gov (United States)

    Adams, S R; Sparkes, M J; Dixon, H B

    1984-01-01

    Adenosine was converted into the arsonomethyl analogue of AMP. The reactions used provide a general route for converting an alcohol, R-CH2-OH, into the arsonomethyl analogue, R-CH2-CH2-AsO3H2, of its phosphate, R-CH2-O-PO3H2. The analogue of AMP proves to be a substrate for rabbit adenylate kinase, which shows a limiting velocity with it of 1/17 that with AMP, a Michaelis constant raised 70-fold to about 10 mM, and hence a specificity constant lowered about 1200-fold. The product of transfer of a phospho group from ATP to the analogue is, like all anhydrides of arsonic acids, unstable to hydrolysis, and so breaks down to yield orthophosphate and regenerate the analogue. Hence adenylate kinase is converted into an ATPase by the presence of the analogue. PMID:6089748

  1. Des pauvres de la politique à la politique des pauvres

    Directory of Open Access Journals (Sweden)

    Ratiba Hadj-Moussa

    2012-01-01

    Full Text Available S’attachant aux nouvelles modalités de production du politique issues des études subalternes, l’article situe dans un premier temps ces travaux et, dans un deuxième temps, en fait une présentation en s’appuyant sur les éléments qui y sont privilégiés et qui font le lien entre « les pauvres et la production du politique ». Cette présentation s’appuie essentiellement sur les travaux portant sur les pays du Sud, en particulier l’Inde et quelques pays du Moyen Orient (l’Égypte et l’Iran. Elle réfère aussi au Maghreb qui est le terrain principal de l’analyse. La présentation tient compte en particulier des travaux qui s’appuient sur des recherches empiriques substantielles mais dont la portée théorique est très peu discutée. Enfin, si le renvoi aux études subalternes ou postcoloniales est dans ce texte non négligeable, il est aussi fait recours à des travaux produits dans des contextes pluralistes, comme la France.Poor Policy to the Policy of the PoorThis article has its origins in the new methods of production of policy based on subaltern studies. Firstly, it will locate these studies and then it will present its main arguments as well as the relationship between “the poor and policy production”. This presentation is based essentially on the works on countries of the south, particularly India, and few other countries from the Middle East (Egypt and Iran. It also refers to North Africa, which is the major fieldwork of this analysis. This presentation takes into account the works that rely upon substantial empirical research but for which the theoretical range is very little. Finally, if the referral to subaltern or postcolonial studies is significant in this article, it also refers to works produced in pluralistic contexts such as France.De los pobres de la política a la política de los pobresBasándose en estudios subalternos, el artículo se sitúa dentro del marco de los nuevos modos de producci

  2. Schopenhauer und die Paradoxien des Erhabenen

    Directory of Open Access Journals (Sweden)

    François Arnaud

    2012-08-01

    Full Text Available http://dx.doi.org/10.5007/1677-2954.2012v11nesp1p145 Die Hauptunterscheidung zwischen den Schopenhauerschen und Kantschen Auffassungen des Erhabenen liegt nach diesem Artikel darin, dass der Zuschauer im letzten Fall zu einer nur möglichen Gefahr muss unterworfen werden, während er im Ersten wirklich erschreckt sein muss. Die Haupttriebfeder des Gefühls des Erhabenen ist nämlich bei Schopenhauer der Einsatz des Willens, der also wirklich bedroht werden muss. Daraus folgen einige Paradoxien und Originalitäten der Schopenhauerschen Lehre des Erhabenen, hauptsächlich aus dem ethischen Aussichtspunkt, deren Spuren ich zu folgen versuche.

  3. Synthesis of phosphono analogues of dihydroxyacetone phosphate and glyceraldehyde 3-phosphate.

    Science.gov (United States)

    Page, P; Blonski, C; Périé, J

    1999-07-01

    The present paper describes the synthetic routes of six phosphono analogues of dihydroxyacetone phosphate and five phosphono analogues of glyceraldehyde 3-phosphate through alpha-, beta- and gamma-hydroxyphosphonate esters precursors containing a protected carbonyl group. In some situations, depending on the sequence used for the deprotection of the phosphonate and carbonyl groups, the aldol/ketol rearrangement allowed the synthesis of either dihydroxyacetone phosphate or glyceraldehyde 3-phosphate analogues from the same precursors. All these analogues are of interest both as active-site probes and as potential substrates for glycolytic enzymes such as fructose 1,6-diphosphate aldolases (EC 4.1.2.13).

  4. Applications of natural analogue studies to Yucca Mountain as a potential high level radioactive waste repository

    International Nuclear Information System (INIS)

    1995-02-01

    The 5-member group convened in Las Vegas, Nov. 11-13, 1991, to clarify the extent to which studies of natural analogues can assist the Yucca Mountain site characterization (SC) project. This document is to provide guidance and recommendations to DOE for the implementation of natural analogue studies in the SC program. Performance assessment, integrity of engineered barriers, and communication to the public and the scientific community are stressed. The reference design being developed by Babcock ampersand Wilcox Fuel Company are reviewed. Guidelines for selecting natural analogues are given. Quality assurance is discussed. Recommendations are given for developing an effective natural analogue program within the SC program

  5. Isolation and structural identification of a novel minoxidil analogue in an illegal dietary supplement: triaminodil.

    Science.gov (United States)

    Lee, Ji Hyun; Park, Han Na; Park, Hyoung Joon; Kim, Nam Sook; Park, Sung-Kwan; Lee, Jongkook; Baek, Sun Young

    2018-01-01

    A new minoxidil analogue was detected in an illegal dietary supplement advertised as a hair-growth treatment. The analogue was identified using ultra-performance liquid chromatography (UPLC), high-resolution mass spectrometry (LC-HR-MS) and nuclear magnetic resonance (NMR) spectroscopy. The compound was structurally elucidated as a minoxidil analogue in which the piperidinyl group of minoxidil was replaced with a pyrrolidinyl group corresponding to a molecular formula of C 8 H 13 N 5 O. The new analogue has been named triaminodil. As this is the first report of the compound, there are no chemical, toxicology or pharmacological data available.

  6. Martian analogue test site - pilbara craton, western Australia

    Science.gov (United States)

    Brown, A.; Allwood, A.; Walter, M. R.; van Kranendonk, M.

    All exploration for life elsewhere depends on extrapolation from our knowledge of Earth. If the target is former microbial life, for example on Mars, there is no better analogue on Earth than the 3.5 billion year old rocks of the Pilbara region, Western Australia. This area is home to signs of the earliest life on Earth in the form of microbe, many famous stromatolitic horizons and carbon isotope biosignatures. These occur in a volcanic terrain, with weathering and hydrothermal alteration, which also has some similarity to Mars. The geology of this region is known in detail after decades of mapping and other studies. Current work includes studies to resolve disputes about the biogenicity of the microfossils and stromatolites. On balance, biological origins are most likely. In any event, problems of demonstrating biogenicity on other planets will be far more severe, and the work on the Pilbara materials will illuminate those problems. Also underway is mineral mapping of the volcanic, hydrothermal and fossiliferous units using both airborne and hand-held short-wave infrared spectrometers, We are able to map the fossiliferous units using this technique and contend that it would be a powerful exploration technique on Mars and elsewhere. Using the Pilbara as an analogue for other bodies in the Solar System can extend to using it as a place to test instrument packages under realistic conditions. The region has good air and road access, and good supporting infrastructure.

  7. Integrating TEMPO and Its Analogues with Visible-Light Photocatalysis.

    Science.gov (United States)

    Lang, Xianjun; Zhao, Jincai

    2018-01-16

    Visible light has risen to become a very important facilitator for selective radical reactions enabled by well-cognized photocatalysts. The renaissance of visible-light photocatalysis on this matter partly relies on integrating it with other fields of catalysis. In parallel, 2,2,6,6-tetramethylpiperidin N-oxide (TEMPO), a quintessential persistent radical, has a wide range of uses owing to its exceptional redox behavior, which gives rise to its latest prominence in catalysis. Therefore, integrating the catalysis of TEMPO with photocatalysis to perform visible-light-induced selective reactions becomes a very convenient marriage of merits. In this context, the integration of different types of photocatalysts, including metal complexes, metal-free organic dyes, and semiconductors, with TEMPO for outstanding organic transformations will be summarized. To expand further the catalytic repertoire, the integration of TEMPOH analogues such as NHPI (N-hydroxyphthalimide) and NHS (N-hydroxysuccinimide) with photocatalysis will also be discussed. Hopefully, these advances will pave the way for more breakthroughs by integrating TEMPO and its analogues with photocatalysis to lead to a valuable blueprint for visible-light-induced selective organic transformations. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  8. A Bosonic Analogue of a Topological Dirac Semi-Metal

    Science.gov (United States)

    Lapa, Matthew; Cho, Gil Young; Hughes, Taylor

    We construct a bosonic analogue of a two-dimensional topological Dirac Semi-Metal (DSM). The low-energy description of the most basic 2D DSM model consists of two Dirac cones at positions +/-k0 in momentum space. The local stability of the Dirac cones is guaranteed by a composite symmetry Z2, where  is time-reversal and  is inversion. This model also exhibits interesting time-reversal and inversion symmetry breaking electromagnetic responses. In this work we construct a bosonic analogue of a DSM by replacing each Dirac cone with a copy of the O (4) Nonlinear Sigma Model (NLSM) with topological theta term and theta angle θ = +/- π . One copy of this NLSM also describes the gapless surface termination of the 3D Bosonic Topological Insulator (BTI). We compute the time-reversal and inversion symmetry breaking electromagnetic responses for our model and show that they are twice the value one gets in the DSM case. We also investigate the local stability of the individual O (4) NLSM's in the BSM model. Along the way we clarify many aspects of the surface theory of the BTI including the electromagnetic response, the charges of vortex excitations, and the stability to symmetry-allowed perturbations. Nsf CAREER DMR-1351895.

  9. Classical analogue of an interstellar travel through a hydrodynamic wormhole

    Science.gov (United States)

    Euvé, L.-P.; Rousseaux, G.

    2017-09-01

    The classical theory of space-time, namely general relativity, suggests but does not demonstrate the existence of so-called wormholes allowing for interstellar journeys. Alternative proposals such as quantum gravity theories are developed nowadays to allow for wormhole travels by assuming hypothetical trans-Planckian effects at tiny scales. Here we show experimentally that analogue traversable and bidirectional wormholes exist in hydrodynamics following a suggestion by Wheeler. Using a water channel, we sent free surface waves on a countercurrent in an analogue gravity setup aiming at showing that hydrodynamic wormhole travels are controlled by a cascade of dispersive scales including surface tension effects: the capillary wavelength plays the role of a Planckian scale below which long gravity waves are transformed into short capillary waves that are able to move at speeds higher than the "flow" of space-time. Whereas our results do not apply to putative astrophysical wormholes per se, we anticipate that they will trigger new ideas to explore quantum gravity physics.

  10. Limonene hydroperoxide analogues show specific patch test reactions.

    Science.gov (United States)

    Christensson, Johanna Bråred; Hellsén, Staffan; Börje, Anna; Karlberg, Ann-Therese

    2014-05-01

    The fragrance terpene R-limonene is a very weak sensitizer, but forms allergenic oxidation products upon contact with air. The primary oxidation products of oxidized limonene, the hydroperoxides, have an important impact on the sensitizing potency of the oxidation mixture. One analogue, limonene-1-hydroperoxide, was experimentally shown to be a significantly more potent sensitizer than limonene-2-hydroperoxide in the local lymph node assay with non-pooled lymph nodes. To investigate the pattern of reactivity among consecutive dermatitis patients to two structurally closely related limonene hydroperoxides, limonene-1-hydroperoxide and limonene-2-hydroperoxide. Limonene-1-hydroperoxide, limonene-2-hydroperoxide, at 0.5% in petrolatum, and oxidized limonene 3.0% pet. were tested in 763 consecutive dermatitis patients. Of the tested materials, limonene-1-hydroperoxide gave most reactions, with 2.4% of the patients showing positive patch test reactions. Limonene-2-hydroperoxide and oxidized R-limonene gave 1.7% and 1.2% positive patch test reactions, respectively. Concomitant positive patch test reactions to other fragrance markers in the baseline series were frequently noted. The results are in accordance with the experimental studies, as limonene-1-hydroperoxide gave more positive patch test reactions in the tested patients than limonene-2-hydroperoxide. Furthermore, the results support the specificity of the allergenic activity of the limonene hydroperoxide analogues and the importance of oxidized limonene as a cause of contact allergy. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  11. Metabolites of saxitoxin analogues in bivalves contaminated by Gymnodinium catenatum.

    Science.gov (United States)

    Vale, Paulo

    2010-01-01

    Bivalve metabolites of saxitoxin analogues, not present in microalgae, were recently described as an important toxin fraction in mussels contaminated by Alexandrium tamarense. These possess very low fluorescence, and require mass spectrometry detection. HILIC-MS was implemented to look for these metabolites in bivalves contaminated during Gymnodinium catenatum blooms at the Portuguese coast. The presence of M1 was tentatively identified in several bivalves, ranging from estuarine (Mytilus galloprovinciallis, Cerastoderma edule and Ruditapes decussatus) to oceanic habitat (Donax trunculus and Ensis spp.). It was hypothesized that M1 could contribute to an important fraction of the profile of STX analogues. M1 was more abundant in estuarine bivalves that retain longer PSP toxins, in the following order: mussels>cockles>clams. These data highlight that the study by fluorimetry alone of the carbamoyl, N-sulfocarbamoyl, and decarbamoyl families is manifestly insufficient to fully understand toxin dynamics in bivalves feeding on G. catenatum without a proper study of hydroxybenzoate and hydroxylated M-toxins.

  12. Parabolic flights as Earth analogue for surface processes on Mars

    Science.gov (United States)

    Kuhn, Nikolaus J.

    2017-04-01

    The interpretation of landforms and environmental archives on Mars with regards to habitability and preservation of traces of life requires a quantitative understanding of the processes that shaped them. Commonly, qualitative similarities in sedimentary rocks between Earth and Mars are used as an analogue to reconstruct the environments in which they formed on Mars. However, flow hydraulics and sedimentation differ between Earth and Mars, requiring a recalibration of models describing runoff, erosion, transport and deposition. Simulation of these processes on Earth is limited because gravity cannot be changed and the trade-off between adjusting e.g. fluid or particle density generates other mismatches, such as fluid viscosity. Computational Fluid Dynamics offer an alternative, but would also require a certain degree of calibration or testing. Parabolic flights offer a possibility to amend the shortcomings of these approaches. Parabolas with reduced gravity last up to 30 seconds, which allows the simulation of sedimentation processes and the measurement of flow hydraulics. This study summarizes the experience gathered during four campaigns of parabolic flights, aimed at identifying potential and limitations of their use as an Earth analogue for surface processes on Mars.

  13. The role of natural analogues in safety assessment and acceptability

    International Nuclear Information System (INIS)

    Papp, Toenis

    1987-01-01

    The safety assessment must evaluate the level of safety for a repository, the confidence that can be placed on the assessment and how well the repository can meet the acceptance criteria of the society. Many of the processes and phenomena that govern the long term performance of a deep geologic repository for radioactive waste also take place in nature. To investigate these natural analogues and try to validate the models on which the safety assessment are based is a main task in the effort to build of confidence in the safety assessments. The assessment of the safety of a repository can, however, not only be based on good models. The possible role of natural analogues or natural evidence in other parts of the safety assessment is discussed. Specially with regard to - the need to demonstrate that all relevant processes have been taken into account, and that the important ones have been validated to an acceptable level for relevant parameters spans, -the definition and analysis of external scenarios for the safety assessment and for the claim that all reasonable scenarios have been addressed, - the public confidence in the long-term relevance of the acceptance criteria. (author)

  14. Historical space psychology: Early terrestrial explorations as Mars analogues

    Science.gov (United States)

    Suedfeld, Peter

    2010-03-01

    The simulation and analogue environments used by psychologists to circumvent the difficulties of conducting research in space lack many of the unique characteristics of future explorations, especially the mission to Mars. This paper suggests that appropriate additional analogues would be the multi-year maritime and terrestrial explorations that mapped the surface of the Earth in previous centuries. These, like Mars, often involved a hazardous trek through unknown territory, flanked by extended, dangerous voyages to and from the exploration sites. Characteristic issues included interpersonal relationships under prolonged stress, stretches of boredom interspersed with intense work demands, the impossibility of rescue, resupply, or other help from home, chronic danger, physical discomfort and lack of privacy, and the crucial role of the leader. Illustrative examples of one important factor, leadership style, are discussed. The examination of such expeditions can help to identify the psychological stressors that are likely to be experienced by Mars explorers, and can also indicate countermeasures to reduce the damaging impact of those stressors.

  15. A low-dimensional analogue of holographic baryons

    Science.gov (United States)

    Bolognesi, Stefano; Sutcliffe, Paul

    2014-04-01

    Baryons in holographic QCD correspond to topological solitons in the bulk. The most prominent example is the Sakai-Sugimoto model, where the bulk soliton in the five-dimensional spacetime of AdS-type can be approximated by the flat space self-dual Yang-Mills instanton with a small size. Recently, the validity of this approximation has been verified by comparison with the numerical field theory solution. However, multi-solitons and solitons with finite density are currently beyond numerical field theory computations. Various approximations have been applied to investigate these important issues and have led to proposals for finite density configurations that include dyonic salt and baryonic popcorn. Here we introduce and investigate a low-dimensional analogue of the Sakai-Sugimoto model, in which the bulk soliton can be approximated by a flat space sigma model instanton. The bulk theory is a baby Skyrme model in a three-dimensional spacetime with negative curvature. The advantage of the lower-dimensional theory is that numerical simulations of multi-solitons and finite density solutions can be performed and compared with flat space instanton approximations. In particular, analogues of dyonic salt and baryonic popcorn configurations are found and analysed.

  16. The costal landslide from analogue experiments: perspectives and limitation

    Science.gov (United States)

    Del Ventisette, C.; Nolesini, T.; Moretti, S.; Fanti, R.

    2010-12-01

    Understanding the triggering mechanism of coastal landslides (triggered and/or developed at air-water interface) and their evolution is fundamental to evaluate their hazard and, predicting the energy, the associated tsunami risk. The aim of this work is to verify the suitability of analogue modelling to understand the triggering mechanism and the evolution of landslide along the costal line. As a starting case study the Sciara del Fuoco (SdF), northwest flank of the volcanic island of Stromboli (Italy), was chosen. The analogue modelling technique has been proven to represent an useful tool to understand many geological processes, as it allows studying the progressive deformation, providing also useful indications about the role of distinct factors controlling the final deformation pattern. The models simulated at a first approximation the geological geometries observed at Stromboli, a composite volcano forming the northernmost island of the Aeolian Archipelago (Tyrrhenian Sea). The activity of Stromboli volcano is characterized by a persistent mild explosive activity at the summit craters sporadically interrupted by episodes of lava effusion and violent paroxysmal explosions as in 2002-2003 and in 2007. During the 2002 effusion a large landslide occurred on the SdF. The landslide caused a tsunami, which produced severe damages along the island shores. A series of analogue models was performed to investigate the influence of two different types of triggering mechanism and the behaviour of landslides both in air and air-water interface: 1) surface bulging due to the intrusion of a dike; 2) accumulation of material due to an uppermost landslide or due to opening of a new vent. The models, constructed in a Plexiglas tank, were scaled to the natural prototype following the geometrical, rheological, kinematical and dynamical similarities (e.g. Hubbert, 1937; Ramberg, 1981). The modelling material (Fontainbleau sand and rice) was sieved on a slope, inclination of which

  17. Isomers chart; Table des isomeres

    Energy Technology Data Exchange (ETDEWEB)

    Dupont-Gautier, P.; Chantelot, S.; Moisson, N. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1967-07-01

    The nuclear isomers are nuclides offering the same mass number and the same atomic number, but different energy levels. In the following chart the zero energy ground states are omitted and the metastable isomers, i.e. of non-zero energy, known and of measurable lifetime, are listed. The lower limit of this lifetime was set here to 0.1 x 10{sup -6} s. The various isomers were classified in increasing lifetimes. (authors) [French] Les isomeres nucleaires sont des nucleides presentant le meme nombre de masse et le meme numero atomique, mais des niveaux energetiques differents. Dans la table suivante, on a neglige les etats fondamentaux d'energie nulle et on a recense les isomeres metastables, c'est-a-dire d'energie non nulle, connus et de periode mesurable. La limite inferieure de cette periode a ete fixee ici a 0,1 x 10{sup -6} s. Les differents isomeres ont ete classes par periodes croissantes. (auteurs)

  18. La structure des verres étudiée par diffraction des neutrons

    Science.gov (United States)

    Cormier, L.

    2003-09-01

    La diffraction des neutrons est une méthode largement utilisée pour déterminer la structure des matériaux amorphes et en particulier des verres. L'utilisation de la méthode de substitution isotopique permet d'extraire les fonctions de distribution de paires partielles centrées autour d'un élément choisi. Nous présentons quelques exemples récents d'études par diffraction des neutrons sur des verres qui ont permis de mieux comprendre à la fois le réseau polymérique de la matrice vitreuse et l'environnement local et à moyenne distance autour des cations. Ces études ont révélées un ordre structural s'étendant au delà des premiers voisins, jusque vers de distances d'environ 10Å. Le couplage avec d'autres méthodes expérimentales (diffraction anormale des rayons X) et des techniques de simulations (dynamique moléculaire, Monte Carlo Inverse ou RMC) sont indispensables pour affiner nos connaissances de la structure des verres.

  19. Promouvoir des systèmes alimentaires sains

    International Development Research Centre (IDRC) Digital Library (Canada)

    fdieudonne

    Le réglement du marketing et l'étiquetage des produits alimentaires. Des politiques pour un environnement alimentaire plus sain. Les politiques et la réglementation touchant les produits alimentaires influent sur l'abordabilité, la disponibilité, l'accessibilité, la diversité des produits sains et les choix des consommateurs en ...

  20. Connaissances et attitudes des manipulateurs radio du Togo sur l ...

    African Journals Online (AJOL)

    Objectif : Evaluer les connaissances et les attitudes des manipulateurs togolais sur l'irradiation médicale des grossesses. Matériels et Méthode : Etude transversale menée en Avril 2011 chez 72 manipulateurs de radiologie des structures sanitaires publiques et privées du Togo. Résultats : Le quart des manipulateurs ...