Simulation of high consequence areas for gas pipelines

OpenAIRE

Orlando Díaz-Parra; Enrique Vera-López

2018-01-01

The gas pipeline is used for the transport of natural gas at a great distance. Risks derived from the handling of a combustible material transported under high pressure, by pipelines that pass close to where people live, makes it necessary to adopt prevention, mitigation and control measures to reduce the effect in case of ignition of a gas leak. This work shows the development of a new mathematical model to determine areas of high consequence and their application, using widely available and...

Some experimental consequences of asymptotically free field theories

International Nuclear Information System (INIS)

Calvo, M.O.

1974-01-01

Several experimental consequences of non-Abelian asymptotically free gauge theories are studied, in particular, second order corrections to the moments of the nonsinglet pieces of the structure functions are calculated. These results are then used to derive corrections to sum rules as well as to obtain direct functional relations between the structure functions. It is found that, in general, the second order corrections involve calculable and uncalculable constants, but the latter can be either estimated or eliminated by considering suitable combinations of structure functions. It is also shown that some of the correction terms increase as one considers higher moments. This remarkable fact, which is likely to persist in higher orders, suggests that all the functional relations that are derived will have questionable validity near threshold; however, away from this region, where higher order corrections are negligible, all these relations will provide an important test of these theories. Finally, it is shown that no similar predictions can be derived for the singlet pieces of the structure functions, since they always involve uncalculable constants

Radiological consequence analysis of a repository for radioactive waste

International Nuclear Information System (INIS)

Fitzpatrick, J.; Buchheim, B.; Hoop, F.J.

1982-01-01

One of the methods under consideration for the disposal of radioactive wastes is emplacement in a repository within deep, continental formations. This paper presents the experience gained in developing a methodology to make an assessment of the radiological consequences both for normal operation and for possible accident situations for a specific repository design in a salt dome at Gorleben in Germany , designed to accommodate all categories of radioactive waste. Radionuclide release scenarios were derived from a systematic analysis of the facility design and proposed operational procedure. Where necessary simple numerical models for such topics as direct radiation exposure from waste containers, release and transport of radionuclides, radiolysis, heat transfer, creep and impact were developed to give a first estimate of the radiological consequences due to radionuclide releases. (author)

Structure activity relationships of quinoxalin-2-one derivatives as platelet-derived growth factor-beta receptor (PDGFbeta R) inhibitors, derived from molecular modeling.

Science.gov (United States)

Mori, Yoshikazu; Hirokawa, Takatsugu; Aoki, Katsuyuki; Satomi, Hisanori; Takeda, Shuichi; Aburada, Masaki; Miyamoto, Ken-ichi

2008-05-01

We previously reported a quinoxalin-2-one compound (Compound 1) that had inhibitory activity equivalent to existing platelet-derived growth factor-beta receptor (PDGFbeta R) inhibitors. Lead optimization of Compound 1 to increase its activity and selectivity, using structural information regarding PDGFbeta R-ligand interactions, is urgently needed. Here we present models of the PDGFbeta R kinase domain complexed with quinoxalin-2-one derivatives. The models were constructed using comparative modeling, molecular dynamics (MD) and ligand docking. In particular, conformations derived from MD, and ligand binding site information presented by alpha-spheres in the pre-docking processing, allowed us to identify optimal protein structures for docking of target ligands. By carrying out molecular modeling and MD of PDGFbeta R in its inactive state, we obtained two structural models having good Compound 1 binding potentials. In order to distinguish the optimal candidate, we evaluated the structural activity relationships (SAR) between the ligand-binding free energies and inhibitory activity values (IC50 values) for available quinoxalin-2-one derivatives. Consequently, a final model with a high SAR was identified. This model included a molecular interaction between the hydrophobic pocket behind the ATP binding site and the substitution region of the quinoxalin-2-one derivatives. These findings should prove useful in lead optimization of quinoxalin-2-one derivatives as PDGFb R inhibitors.

Applied Neuroethics: the practical Consequences of Neuropositivism

Directory of Open Access Journals (Sweden)

Domingo García-Marzá

2017-02-01

Full Text Available The objective of this work is to show the practical consequences of the positivist selfcomprehension of applied neuroethics. This ethics deals with the ethical and social impacts that derive from applying neuroscientific findings, especially from neurotechnologies. The intention is to show that in order to perform this task, neuroethics must exceed the dominant neuropositivist paradigm that only leads it to dissolve the moral domain and, in the practical domain, an accomplice-type silence when faced with problems that arise upon applying neurosciences. To this end, we take the following steps: we firstly analyse the basic features of the whole applied ethics and with them, the origin and objectives of applied neuroethics. We will then see how neuroethical research confuses the social domain with the moral domain, and how it thus eliminates access to any ethical perspective. Finally, we will exemplify the practical consequences of this dissolution in public politics by analysing the role that may comply, but does not comply, with applied neuroethics as opposed to the neuropower created by neurotechnologies.

Mortality, health, social and economic consequences of amyotrophic lateral sclerosis

DEFF Research Database (Denmark)

Jennum, Poul; Ibsen, Rikke Falkner; Pedersen, Stephen Wørlich

2013-01-01

included labour supply and social transfer payments, and were based on income data derived from Coherent Social Statistics. Patients with a diagnosis of ALS had poor survival. The average (95 % CI) 5-year survival rate was 0.278 (0.358-0.298) compared with 0.865 (0.858-0.872) among controls. Patients...... to compensate for the social consequences to patients by increasing their net income after ALS diagnosis....

Consequence Prioritization Process for Potential High Consequence Events (HCE)

Energy Technology Data Exchange (ETDEWEB)

Freeman, Sarah G. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

2016-10-31

This document describes the process for Consequence Prioritization, the first phase of the Consequence-Driven Cyber-Informed Engineering (CCE) framework. The primary goal of Consequence Prioritization is to identify potential disruptive events that would significantly inhibit an organization’s ability to provide the critical services and functions deemed fundamental to their business mission. These disruptive events, defined as High Consequence Events (HCE), include both events that have occurred or could be realized through an attack of critical infrastructure owner assets. While other efforts have been initiated to identify and mitigate disruptive events at the national security level, such as Presidential Policy Directive 41 (PPD-41), this process is intended to be used by individual organizations to evaluate events that fall below the threshold for a national security. Described another way, Consequence Prioritization considers threats greater than those addressable by standard cyber-hygiene and includes the consideration of events that go beyond a traditional continuity of operations (COOP) perspective. Finally, Consequence Prioritization is most successful when organizations adopt a multi-disciplinary approach, engaging both cyber security and engineering expertise, as in-depth engineering perspectives are required to recognize and characterize and mitigate HCEs. Figure 1 provides a high-level overview of the prioritization process.

Modeling of criticality accidents and their environmental consequences

International Nuclear Information System (INIS)

Thomas, W.; Gmal, B.

1987-01-01

In the Federal Republic of Germany, potential radiological consequences of accidental nuclear criticality have to be evaluated in the licensing procedure for fuel cycle facilities. A prerequisite to this evaluation is to establish conceivable accident scenarios. First, possibilities for a criticality exceeding the generally applied double contingency principle of safety are identified by screening the equipment and operation of the facility. Identification of undetected accumulations of fissile material or incorrect transfer of fissile solution to unfavorable geometry normally are most important. Second, relevant and credible scenarios causing the most severe consequences are derived from these possibilities. For the identified relevant scenarios, time-dependent fission rates and reasonable numbers for peak power and total fissions must be determined. Experience from real accidents and experiments (KEWB, SPERT, CRAC, SILENE) has been evaluated using empirical formulas. To model the time-dependent behavior of criticality excursions in fissile solutions, a computer program FELIX has been developed

Leghemoglobin-derived radicals. Evidence for multiple protein-derived radicals and the initiation of peribacteroid membrane damage

DEFF Research Database (Denmark)

Moreau, S; Davies, Michael Jonathan; Mathieu, C

1996-01-01

, with the consequent generation of lipid-derived radicals. The formation of such radicals may result in the depletion of membrane antioxidants and the initiation of lipid peroxidation. This transfer of damage from the heme center via the protein surface to neighboring membranes may be of considerable biological......-derived phenoxyl radical present at Tyr-133 in the soybean protein and Tyr-138 in the lupin protein. To obtain further information on these protein radicals and their potential interaction with the physiologically important peribacteroid membrane (which surrounds the microsymbiont in vivo), EPR spin trapping......); these radicals may be side chain- or alpha-carbon-derived, their exact sites have not been determined. Some of these radicals are on the protein surface and may be key intermediates in the formation of protein dimers. These radicals have been shown to be capable of reacting with peribacteroid membrane fractions...

The covariance matrix of derived quantities and their combination

International Nuclear Information System (INIS)

Zhao, Z.; Perey, F.G.

1992-06-01

The covariance matrix of quantities derived from measured data via nonlinear relations are only approximate since they are functions of the measured data taken as estimates for the true values of the measured quantities. The evaluation of such derived quantities entails new estimates for the true values of the measured quantities and consequently implies a modification of the covariance matrix of the derived quantities that was used in the evaluation process. Failure to recognize such an implication can lead to inconsistencies between the results of different evaluation strategies. In this report we show that an iterative procedure can eliminate such inconsistencies

Parameterization of the driving time in the evacuation or fast relocation model of an accident consequence code

International Nuclear Information System (INIS)

Pfeffer, W.; Hofer, E.; Nowak, E.; Schnadt, H.

1988-01-01

The model of protective measures in the accident consequence code system UFOMOD of the German Risk Study, Phase B, requires the driving times of the population to be evacuated for the evaluation of the dose received during the evacuation. The parameter values are derived from evacuation simulations carried out with the code EVAS for 36 sectors from various sites. The simulations indicated that the driving time strongly depends on the population density, whereas other influences are less important. It was decided to use different driving times in the consequence code for each of four population density classes as well as for each of three or four fractions of the population in a sector. The variability between sectors of a class was estimated from the 36 sectors, in order to derive subjective probability distributions that are to model the uncertainty in the parameter value to be used for any of the fractions in a particular sector for which an EVAS simulation has not yet been performed. To this end also the impact of the uncertainties in the parameters and modelling assumptions of EVAS on the simulated times was quantified using expert judgement. The distributions permit the derivation of a set of driving times to be used as so-called ''best estimate'' or reference values in the accident consequence code. Additionally they are directly applicable in an uncertainty and sensitivity analysis

Clinical consequences of sensitisation in affective disorder

DEFF Research Database (Denmark)

Kessing, L V; Mortensen, P B; Bolwig, T G

1998-01-01

Clinically derived measures of the initial course of episodes might reflect a process of sensitisation in affective disorder. However, the clinical consequences of such measures have not been investigated. The predictive effect of measures of the initial course of episodes was investigated...... period between initial episodes of the illness, reflecting a great intensity of illness, predicted increased risk of subsequent development of dementia, and for unipolar patients, decreased risk of subsequent alcoholism. Surprisingly, a progressive course, with decreasing intervals between initial...... episodes of the illness, had no predictive effect. Similarly, no predictive effects on the risk of death or suicidal acts could be demonstrated with any measure of the initial course of episodes....

Initial value formulation of higher derivative gravity

International Nuclear Information System (INIS)

Noakes, D.R.

1983-01-01

The initial value problem is considered for the conformally coupled scalar field and higher derivative gravity, by expressing the equations of each theory in harmonic coordinates. For each theory it is shown that the (vacuum) equations can take the form of a diagonal hyperbolic system with constraints on the initial data. Consequently these theories possess well-posed initial value formulations

The Educational Consequences of Teen Childbearing

Science.gov (United States)

Kane, Jennifer B.; Morgan, S. Philip; Harris, Kathleen Mullan; Guilkey, David K.

2013-01-01

A huge literature shows that teen mothers face a variety of detriments across the life course, including truncated educational attainment. To what extent is this association causal? The estimated effects of teen motherhood on schooling vary widely, ranging from no discernible difference to 2.6 fewer years among teen mothers. The magnitude of educational consequences is therefore uncertain, despite voluminous policy and prevention efforts that rest on the assumption of a negative and presumably causal effect. This study adjudicates between two potential sources of inconsistency in the literature—methodological differences or cohort differences—by using a single, high-quality data source: namely, The National Longitudinal Study of Adolescent Health. We replicate analyses across four different statistical strategies: ordinary least squares regression; propensity score matching; and parametric and semiparametric maximum likelihood estimation. Results demonstrate educational consequences of teen childbearing, with estimated effects between 0.7 and 1.9 fewer years of schooling among teen mothers. We select our preferred estimate (0.7), derived from semiparametric maximum likelihood estimation, on the basis of weighing the strengths and limitations of each approach. Based on the range of estimated effects observed in our study, we speculate that variable statistical methods are the likely source of inconsistency in the past. We conclude by discussing implications for future research and policy, and recommend that future studies employ a similar multimethod approach to evaluate findings. PMID:24078155

Mechanisms and consequences of paternally transmitted chromosomal abnormalities

Energy Technology Data Exchange (ETDEWEB)

Marchetti, F; Wyrobek, A J

2005-04-05

Paternally transmitted chromosomal damage has been associated with pregnancy loss, developmental and morphological defects, infant mortality, infertility, and genetic diseases in the offspring including cancer. There is epidemiological evidence linking paternal exposure to occupational or environmental agents with an increased risk of abnormal reproductive outcomes. There is also a large body of literature on germ cell mutagenesis in rodents showing that treatment of male germ cells with mutagens has dramatic consequences on reproduction producing effects such as those observed in human epidemiological studies. However, we know very little about the etiology, transmission and early embryonic consequences of paternally-derived chromosomal abnormalities. The available evidence suggests that: (1) there are distinct patterns of germ cell-stage differences in the sensitivity of induction of transmissible genetic damage with male postmeiotic cells being the most sensitive; (2) cytogenetic abnormalities at first metaphase after fertilization are critical intermediates between paternal exposure and abnormal reproductive outcomes; and, (3) there are maternally susceptibility factors that may have profound effects on the amount of sperm DNA damage that is converted into chromosomal aberrations in the zygote and directly affect the risk for abnormal reproductive outcomes.

Implementing shared decision-making: consider all the consequences.

Science.gov (United States)

Elwyn, Glyn; Frosch, Dominick L; Kobrin, Sarah

2016-08-08

challenges. In the long-term, shared decision-making might lead to changes in resource utilization, perhaps to reductions in cost, and to modification of workforce composition. Despite the gradual shift to value-based payment, some organizations, motivated by continued income derived from achieving high volumes of procedures and contacts, will see this as a negative consequence. We suggest that a broader conceptualization and measurement of shared decision-making would provide a more substantive evidence base to guide implementation. We outline a framework which illustrates a hypothesized set of proximal, distal, and distant consequences that might occur if collaboration and deliberation could be achieved routinely, proposing that well-informed preference-based patient decisions might lead to safer, more cost-effective healthcare, which in turn might result in reduced utilization rates and improved health outcomes.

Genetic consequences of anagenetic speciation in Acer okamotoanum (Sapindaceae) on Ullung Island, Korea.

Science.gov (United States)

Takayama, Koji; Sun, Byung-Yun; Stuessy, Tod F

2012-02-01

Anagenesis (also known as phyletic speciation) is an important process of speciation in endemic species of oceanic islands. We investigated genetic variation in Acer okamotoanum, an anagenetically derived species endemic to Ullung Island, South Korea, to infer genetic consequences of anagenesis in comparison with other groups that have undergone cladogenesis (and adaptive radiation). We examined genetic variation based on eight polymorphic microsatellite markers from 145 individuals of A. okamotoanum and 134 individuals of its putative progenitor A. mono. We employed standard population genetic analyses, clustering analyses, Bayesian clustering analyses in STRUCTURE and bottleneck analyses. Based on both the Neighbor-Joining tree and Bayesian clustering analyses, clear genetic distinctions were found between the two species. Genetic diversity in terms of allelic richness and heterozygosity shows slightly lower levels in A. okamotoanum in comparison with A. mono. Bayesian clustering analyses showed a relatively high F-value in the cluster of A. okamotoanum, suggesting a strong episode of genetic drift during colonization and speciation. There was no clear evidence of a bottleneck based on allelic frequency distribution and excess of observed heterozygotes, but the M-ratio indicated a historical bottleneck in several populations of A. okamotoanum. No geographical genetic structure within the island was found, and the genetic variation among populations of A. okamotoanum was quite low. We hypothesized that genetic consequences of oceanic-endemic plants derived via anagenesis would be quite different from those derived via cladogenesis. Populations of A. okamotoanum form a cluster and are clearly differentiated from A. mono, which suggests a single origin for the anagenetically derived island endemic. No pattern of geographical differentiation of populations occurs in A. okamotoanum, which supports the concept of initial founder populations diverging through time by

Macroeconomic Consequences of Outsourcing. An Analysis of Growth, Welfare and Product Variety

OpenAIRE

de Groot, H.L.F.

1998-01-01

Outsourcing of non-core activities by firms is nowadays a common business strategy. This paper provides a theoretical framework for analyzing a firms’ incentive to follow such a strategy and its consequences for macroeconomic variables like growth and product variety. We divide production activities into core and non-core activities. Non-core activities can be performed within the firm or can be mediated by the market. We will derive conditions under which outsourcing will occur, and under wh...

Consequences of sludge composition on combustion performance derived from thermogravimetry analysis

Energy Technology Data Exchange (ETDEWEB)

Li, Meiyan; Xiao, Benyi; Wang, Xu; Liu, Junxin, E-mail: jxliu@rcees.ac.cn

2015-01-15

Highlights: • Volatiles, particularly proteins, play a key role in sludge combustion. • Sludge combustion performance varies with different sludge organic concentrations. • Carbohydrates significantly affect the combustion rate in the second stage. • Combustion performance of digested sludge is more negative compared with others. - Abstract: Wastewater treatment plants produce millions of tons of sewage sludge. Sewage sludge is recognized as a promising feedstock for power generation via combustion and can be used for energy crisis adaption. We aimed to investigate the quantitative effects of various sludge characteristics on the overall sludge combustion process performance. Different types of sewage sludge were derived from numerous wastewater treatment plants in Beijing for further thermogravimetric analysis. Thermogravimetric–differential thermogravimetric curves were used to compare the performance of the studied samples. Proximate analytical data, organic compositions, elementary composition, and calorific value of the samples were determined. The relationship between combustion performance and sludge composition was also investigated. Results showed that the performance of sludge combustion was significantly affected by the concentration of protein, which is the main component of volatiles. Carbohydrates and lipids were not correlated with combustion performance, unlike protein. Overall, combustion performance varied with different sludge organic composition. The combustion rate of carbohydrates was higher than those of protein and lipid, and carbohydrate weight loss mainly occurred during the second stage (175–300 °C). Carbohydrates have a substantial effect on the rate of system combustion during the second stage considering the specific combustion feature. Additionally, the combustion performance of digested sewage sludge is more negative than the others.

Consequences of sludge composition on combustion performance derived from thermogravimetry analysis

International Nuclear Information System (INIS)

Li, Meiyan; Xiao, Benyi; Wang, Xu; Liu, Junxin

2015-01-01

Highlights: • Volatiles, particularly proteins, play a key role in sludge combustion. • Sludge combustion performance varies with different sludge organic concentrations. • Carbohydrates significantly affect the combustion rate in the second stage. • Combustion performance of digested sludge is more negative compared with others. - Abstract: Wastewater treatment plants produce millions of tons of sewage sludge. Sewage sludge is recognized as a promising feedstock for power generation via combustion and can be used for energy crisis adaption. We aimed to investigate the quantitative effects of various sludge characteristics on the overall sludge combustion process performance. Different types of sewage sludge were derived from numerous wastewater treatment plants in Beijing for further thermogravimetric analysis. Thermogravimetric–differential thermogravimetric curves were used to compare the performance of the studied samples. Proximate analytical data, organic compositions, elementary composition, and calorific value of the samples were determined. The relationship between combustion performance and sludge composition was also investigated. Results showed that the performance of sludge combustion was significantly affected by the concentration of protein, which is the main component of volatiles. Carbohydrates and lipids were not correlated with combustion performance, unlike protein. Overall, combustion performance varied with different sludge organic composition. The combustion rate of carbohydrates was higher than those of protein and lipid, and carbohydrate weight loss mainly occurred during the second stage (175–300 °C). Carbohydrates have a substantial effect on the rate of system combustion during the second stage considering the specific combustion feature. Additionally, the combustion performance of digested sewage sludge is more negative than the others

Environmental Consequences of Wildlife Tourism: The Use of Formalised Qualitative Models

Directory of Open Access Journals (Sweden)

Veselý Štěpán

2015-09-01

Full Text Available The paper presents a simple qualitative model of environmental consequences of wildlife tourism. Qualitative models use just three values: Positive/Increasing, Zero/Constant and Negative/Decreasing. Such quantifiers of trends are the least information intensive. Qualitative models can be useful, since models of wildlife tourism include such variables as, for example, Biodiversity (BIO, Animals’ habituation to tourists (HAB or Plant composition change (PLA that are sometimes difficult or costly to quantify. Hence, a significant fraction of available information about wildlife tourism and its consequences is not of numerical nature, for example, if HAB is increasing then BIO is decreasing. Such equationless relations are studied in this paper. The model has 10 variables and 20 equationless pairwise interrelations among them. The model is solved and 15 solutions, that is, scenarios are obtained. All qualitative states, including the first and second qualitative derivatives with respect to time, of all variables are specified for each scenario.

Enabling quaternion derivatives: the generalized HR calculus

Science.gov (United States)

Xu, Dongpo; Jahanchahi, Cyrus; Took, Clive C.; Mandic, Danilo P.

2015-01-01

Quaternion derivatives exist only for a very restricted class of analytic (regular) functions; however, in many applications, functions of interest are real-valued and hence not analytic, a typical case being the standard real mean square error objective function. The recent HR calculus is a step forward and provides a way to calculate derivatives and gradients of both analytic and non-analytic functions of quaternion variables; however, the HR calculus can become cumbersome in complex optimization problems due to the lack of rigorous product and chain rules, a consequence of the non-commutativity of quaternion algebra. To address this issue, we introduce the generalized HR (GHR) derivatives which employ quaternion rotations in a general orthogonal system and provide the left- and right-hand versions of the quaternion derivative of general functions. The GHR calculus also solves the long-standing problems of product and chain rules, mean-value theorem and Taylor's theorem in the quaternion field. At the core of the proposed GHR calculus is quaternion rotation, which makes it possible to extend the principle to other functional calculi in non-commutative settings. Examples in statistical learning theory and adaptive signal processing support the analysis. PMID:26361555

Advanced glycation end-products: a biological consequence of lifestyle contributing to cancer disparity

OpenAIRE

Turner, David P.

2015-01-01

Low income, poor diet, obesity and a lack of exercise are inter-related lifestyle factors that can profoundly alter our biological make-up to increase cancer risk, growth and development. We recently reported a potential mechanistic link between carbohydrate derived metabolites and cancer which may provide a biological consequence of lifestyle that can directly impact tumor biology. Advanced glycation end-products (AGEs) are reactive metabolites produced as a by-product of sugar metabolism. F...

Childhood Obesity Causes & Consequences

Science.gov (United States)

... and Local Programs Related Topics Diabetes Nutrition Childhood Obesity Causes & Consequences Recommend on Facebook Tweet Share Compartir ... determine how a community is designed. Consequences of Obesity More Immediate Health Risks Obesity during childhood can ...

Treating autoimmune disorders with venom-derived peptides.

Science.gov (United States)

Shen, Bingzheng; Cao, Zhijian; Li, Wenxin; Sabatier, Jean-Marc; Wu, Yingliang

2017-09-01

The effective treatment of autoimmune diseases remains a challenge. Voltage-gated potassium Kv1.3 channels, which are expressed in lymphocytes, are a new therapeutic target for treating autoimmune disease. Consequently, Kv1.3 channel-inhibiting venom-derived peptides are a prospective resource for new drug discovery and clinical application. Area covered: Preclinical and clinical studies have produced a wealth of information on Kv1.3 channel-inhibiting venom-derived peptides, especially from venomous scorpions and sea anemones. This review highlights the advances in screening and design of these peptides with diverse structures and potencies. It focuses on representative strategies for improving peptide selectivity and discusses the preclinical research on those venom-derived peptides as well as their clinical developmental status. Expert opinion: Encouraging results indicate that peptides isolated from the venom of venomous animals are a large resource for discovering immunomodulators that act on Kv1.3 channels. Since the structural diversity of venom-derived peptides determines the variety of their pharmacological activities, the design and optimization of venom-peptides for improved Kv1.3 channel-specificity has been advanced through some representative strategies, such as peptide chemical modification, amino acid residue truncation and binding interface modulation. These advances should further accelerate research, development and the future clinical application of venom-derived peptides selectively targeting Kv1.3 channels.

Towards a realistic estimation for the risk to the public derived from a nuclear accident

Energy Technology Data Exchange (ETDEWEB)

Carrillo, D; Diaz de la Cruz, F.

1985-01-01

The controversy arised during the last decade around civil uses of nuclear energy has been focalized, principally, in its questionability as energetic resource, basing on the safety aspects and consequently on the risk magnitude associated with a nuclear accident, from which could arise significative releases of radioactivity to the environment. The reactor safety studies developed in the last decade overestimated, in some orders of magnitude, the radiological consequences, and therefore the nuclear risk derived from the operation of such installations. In this moment, after the lessons learned from Three Mile Island accident and the studies and researches, starting afterwards, it is considered suitable to develop a comparison of the above mentioned risk which allows an approach between its real value and that one derived from social perception.

Unrealized potential and residual consequences of electronic prescribing on pharmacy workflow in the outpatient pharmacy.

Science.gov (United States)

Nanji, Karen C; Rothschild, Jeffrey M; Boehne, Jennifer J; Keohane, Carol A; Ash, Joan S; Poon, Eric G

2014-01-01

Electronic prescribing systems have often been promoted as a tool for reducing medication errors and adverse drug events. Recent evidence has revealed that adoption of electronic prescribing systems can lead to unintended consequences such as the introduction of new errors. The purpose of this study is to identify and characterize the unrealized potential and residual consequences of electronic prescribing on pharmacy workflow in an outpatient pharmacy. A multidisciplinary team conducted direct observations of workflow in an independent pharmacy and semi-structured interviews with pharmacy staff members about their perceptions of the unrealized potential and residual consequences of electronic prescribing systems. We used qualitative methods to iteratively analyze text data using a grounded theory approach, and derive a list of major themes and subthemes related to the unrealized potential and residual consequences of electronic prescribing. We identified the following five themes: Communication, workflow disruption, cost, technology, and opportunity for new errors. These contained 26 unique subthemes representing different facets of our observations and the pharmacy staff's perceptions of the unrealized potential and residual consequences of electronic prescribing. We offer targeted solutions to improve electronic prescribing systems by addressing the unrealized potential and residual consequences that we identified. These recommendations may be applied not only to improve staff perceptions of electronic prescribing systems but also to improve the design and/or selection of these systems in order to optimize communication and workflow within pharmacies while minimizing both cost and the potential for the introduction of new errors.

Is higher-derivative gravity a good therapy to the causal pathologies of Goedel-type universes

International Nuclear Information System (INIS)

Accioly, A.J.

1988-01-01

The possibility of considering higher-derivative gravity as a therapy to the causal pathologies of Goedel-type universes is investigated. As a consequence an unusual cosmological solution is obtained. (author) [pt

Recognition by symmetry derivatives and the generalized structure tensor.

Science.gov (United States)

Bigun, Josef; Bigun, Tomas; Nilsson, Kenneth

2004-12-01

We suggest a set of complex differential operators that can be used to produce and filter dense orientation (tensor) fields for feature extraction, matching, and pattern recognition. We present results on the invariance properties of these operators, that we call symmetry derivatives. These show that, in contrast to ordinary derivatives, all orders of symmetry derivatives of Gaussians yield a remarkable invariance: They are obtained by replacing the original differential polynomial with the same polynomial, but using ordinary coordinates x and y corresponding to partial derivatives. Moreover, the symmetry derivatives of Gaussians are closed under the convolution operator and they are invariant to the Fourier transform. The equivalent of the structure tensor, representing and extracting orientations of curve patterns, had previously been shown to hold in harmonic coordinates in a nearly identical manner. As a result, positions, orientations, and certainties of intricate patterns, e.g., spirals, crosses, parabolic shapes, can be modeled by use of symmetry derivatives of Gaussians with greater analytical precision as well as computational efficiency. Since Gaussians and their derivatives are utilized extensively in image processing, the revealed properties have practical consequences for local orientation based feature extraction. The usefulness of these results is demonstrated by two applications: 1) tracking cross markers in long image sequences from vehicle crash tests and 2) alignment of noisy fingerprints.

The projected relative index of consequence equivalence of transport of radioactive materials

International Nuclear Information System (INIS)

Nandakumar, A.N.

1999-01-01

The need exists for defining a unit risk factor to enable analysis to make a proper decision when faced with many options relating to the transport of radioactive materials between sites. A method is discussed for deriving such a factor with reference to the collective dose receivable due to the transport of radioactive material incidental to the production of one GWe.a of nuclear power. This quantity would enable the analyst to determine the projected relative index of consequence equivalence (PRICE) for the transport of various types of radioactive materials. (author)

Consequence Management - Ready or Not?

Science.gov (United States)

2003-04-07

Defense will have sufficient capability and be ready to respond to a Weapons of Mass Destruction/ Effects attack. An effective consequence management...Defense adopts the National Military Strategy and its consequence management approach, it must identify Weapons of Mass Destruction/ Effects threats...that the Department of Defense: develop Weapons of Mass Destruction/ Effects performance standards for response assets; implement a consequence

Towards a realistic estimation for the risk to the public derived from a nuclear accident

International Nuclear Information System (INIS)

Carrillo, D.; Diaz de la Cruz, F.

1985-01-01

The controversy arised during the last decade around civil uses of nuclear energy has been focalized, principally, in its questionability as energetic resource, basing on the safety aspects and consequently on the risk magnitude associated with a nuclear accident, from which could arise significative releases of radioactivity to the environment. The reactor safety studies developed in the last decade overestimated, in some orders of magnitude, the radiological consequences, and therefore the nuclear risk derived from the operation of such installations. In this moment, after the lessons learned from Three Mile Island accident and the studies and researches, starting afterwards, it is considered suitable to develop a comparison of the above mentioned risk which allows an approach between its real value and that one derived from social perception. (author)

The health-related, social, and economic consequences of parkinsonism: a controlled national study

DEFF Research Database (Denmark)

Zoetmulder, Marielle

2011-01-01

on income data derived from the Coherent Social Statistics. Patients with PD and AP had significantly higher rates of health-related contact and medication use and a higher socioeconomic cost. Furthermore, they had very low employment rates, and those in employment had a lower income level than employed...... sample. Using records from the Danish National Patient Registry (1997-2007), 13,400 PD and 647 AP patients were identified and compared with, respectively, 53,600 and 2,588 control cases randomly selected with respect to age, gender, civil status, and geographic location. Direct costs including....../$1,165), respectively. The employment- and health-related consequences could be identified up to 8 years before the first diagnosis and increased with disease advancement. PD and AP have major socioeconomic consequences for patients and society. The health effects are present for up to more than 8 years before...

Consequence Based Design. An approach for integrating computational collaborative models (Integrated Dynamic Models) in the building design phase

DEFF Research Database (Denmark)

Negendahl, Kristoffer

relies on various advancements in the area of integrated dynamic models. It also relies on the application and test of the approach in practice to evaluate the Consequence based design and the use of integrated dynamic models. As a result, the Consequence based design approach has been applied in five...... and define new ways to implement integrated dynamic models for the following project. In parallel, seven different developments of new methods, tools and algorithms have been performed to support the application of the approach. The developments concern: Decision diagrams – to clarify goals and the ability...... affect the design process and collaboration between building designers and simulationists. Within the limits of applying the approach of Consequence based design to five case studies, followed by documentation based on interviews, surveys and project related documentations derived from internal reports...

Derivation of Batho's correction factor for heterogeneities

International Nuclear Information System (INIS)

Lulu, B.A.; Bjaerngard, B.E.

1982-01-01

Batho's correction factor for dose in a heterogeneous, layered medium is derived from the tissue--air ratio method (TARM). The reason why the Batho factor is superior to the TARM factor at low energy is ascribed to the fact that it accounts for the distribution of the scatter-generating matter along the centerline. The poor behavior of the Batho factor at high energies is explained as a consequence of the lack of electron equilibrium at appreciable depth below the surface. Key words: Batho factor, heterogeneity, inhomogeneity, tissue--air ratio method

Boundary layer heights derived from velocity spectra

Energy Technology Data Exchange (ETDEWEB)

Hoejstrup, J.; Barthelmie, R.J. [Risoe National Lab., Roskilde (Denmark); Kaellstrand, B. [Univ. of Uppsala, Uppsala (Sweden)

1997-10-01

It is a well-known fact that the height of the mixed layer determines the size of the largest and most energetic eddies that can be observed in the unstable boundary layer, and consequently a peak can be observed in the power spectra of the along-wind velocity component at scales comparable to the mixed layer depth. We will now show how the mixed layer depth can be derived from the u-specta and the results will be compared with direct measurements using pibal and tethersonde measurements. (au)

Subjective Evaluations of Alcohol-Related Consequences among College Students: Experience with Consequences Matters

Science.gov (United States)

Leavens, Eleanor L.; Leffingwell, Thad R.; Miller, Mary Beth; Brett, Emma I.; Lombardi, Nathaniel

2017-01-01

Objective: Research suggests college students rate some alcohol-related consequences less negatively than others, yet it is unclear how or when these differences in perception develop. The current study compared college students' subjective evaluations of alcohol-related consequences that they had and had not experienced in order to test the…

The State’s obligation to protect the individuals lives from the consequences of domestic violence: Kosovo case

Directory of Open Access Journals (Sweden)

MSc. Vilard Bytyqi

2016-07-01

Full Text Available The aim of this paper is to treat the important aspects, which deal with State’s obligations to protect individuals’ lives from the consequences of the domestic violence. Thus, domestic violence is a concerning issue, which derives many consequences that sometimes are irreparable. In many cases, the State is obliged to save individuals’ lives from the effects of the domestic violence. The State will not be held responsible in all the cases for the consequences of the domestic violence. Due to the scarcity of the regulation of all the situations in the normative terms, the judicial practice that considers the cases of the right to live has evolved greatly, such that it has set many standards in case of increased institutional responsibility towards the consequences caused by the domestic violence. Due to a practical elaboration, the paper as such will focus in the treatment of cases from the judicial practice in the context of the State’s obligation to save individual’s life, whose life is endangered. Furthermore, there will also be an emphasis in the protection of the right to life and the State’s responsibility in relation to the consequences caused by the actions of the third parties.

Completely monotonic functions related to logarithmic derivatives of entire functions

DEFF Research Database (Denmark)

Pedersen, Henrik Laurberg

2011-01-01

The logarithmic derivative l(x) of an entire function of genus p and having only non-positive zeros is represented in terms of a Stieltjes function. As a consequence, (-1)p(xml(x))(m+p) is a completely monotonic function for all m ≥ 0. This generalizes earlier results on complete monotonicity...... of functions related to Euler's psi-function. Applications to Barnes' multiple gamma functions are given....

Feynman graph derivation of Einstein quadrupole formula

International Nuclear Information System (INIS)

Dass, N.D.H.; Soni, V.

1980-11-01

The one graviton transition operator, and consequently, the classical energy loss formula for gravitational radiation are derived from the Feynman graphs of helicity +- 2 theories of gravitation. The calculations are done both for the case of electromagnetic and gravitational scattering. The departure of the in and out states from plane waves owing to the long range nature of gravitation is taken into account to improve the Born approximation calculations. This also includes a long range modification of the graviton wave function which is shown to be equivalent to the classical problem of the true light cones deviating logarithmically at large distances from the flat space light cones. The transition from the S-matrix elements calculated graphically to the graviton transition operator is done by using complimentarity of space-time and momentum descriptions. The energy loss formula derived originally by Einstein is shown to be correct. (Auth.)

The anti-Trichomonas vaginalis phloroglucinol derivative isoaustrobrasilol B modulates extracellular nucleotide hydrolysis.

Science.gov (United States)

Menezes, Camila Braz; Rigo, Graziela Vargas; Bridi, Henrique; Trentin, Danielle da Silva; Macedo, Alexandre José; von Poser, Gilsane Lino; Tasca, Tiana

2017-11-01

Trichomonas vaginalis causes trichomoniasis, a neglected sexually transmitted disease. Due to severe health consequences and treatment failure, new therapeutic alternatives are crucial. Phloroglucinols from southern Brazilian Hypericum species demonstrated anti-T. vaginalis and anti-Leishmania amazonensis activities. The modulation of biochemical pathways involved in the control of inflammatory response by ectonucleotidases, NTPDase, and ecto-5'-nucleotidase represents new targets for combating protozoa. This study investigated the activity of phloroglucinol derivatives of Hypericum species from southern Brazil against T. vaginalis as well as its ability on modulating parasite ectonucleotidases and, consequently, immune parameters through ATP and adenosine effects. Phloroglucinol derivatives screening revealed activity for isoaustrobrasilol B (IC 50 38 μm) with no hemolytic activity. Although the most active compound induced cytotoxicity against a mammalian cell lineage, the in vivo model evidenced absence of toxicity. Isoaustrobrasilol B significantly inhibited NTPDase and ecto-5'-nucleotidase activities, and the immune modulation attributed to extracellular nucleotide accumulation was evaluated. The production of ROS and IL-6 by T. vaginalis-stimulated neutrophils was not affected by the treatment. Conversely, IL-8 levels were significantly enhanced. The associative mechanism of trophozoites death and ectonucleotidases modulation by isoaustrobrasilol B may increase the susceptibility of T. vaginalis to host innate immune cell like neutrophils consequently, contributing to parasite clearance. © 2017 John Wiley & Sons A/S.

The nuclear accidents: Causes and consequences

International Nuclear Information System (INIS)

Rochd, M.

1988-01-01

The author discussed and compared the real causes of T.M.I. and Chernobyl accidents and cited their consequences. To better understand how these accidents occurred, a brief description of PWR type (reactor type of T.M.I.) and of RBMK type (reactor type of Chernobyl) has been presented. The author has also set out briefly the safety analysis objectives and the three barriers established to protect the public against the radiological consequences. To distinguish failures that cause severe accidents and to analyze them in details, it is necessary to classify the accidents. There are many ways to do it according to their initiator event, or to their frequency, or to their degree of gravity. The safety criteria adopted by nuclear industry have been explained. These criteria specify the limits of certain physical parameters that should not be exceeded in case of incidents or accidents. To compare the real causes of T.M.I. and Chernobyl accidents, the events that led to both have been presented. As observed the main common contributing factors in both cases are that the operators did not pay attention to warnings and signals that were available to them and that they were not trained to handle these accident sequences. The essential conclusions derived from these severe accidents are: -The improvement of operators competence contribute to reduce the accident risks; -The rapid and correct diagnosis of real conditions at each point of the accidents permits an appropriate behavior that would bring the plant to a stable state; -Competent technical teams have to intervene and to assist the operators in case of emergency; -Emergency plans and an international collaboration are necessary to limit the accident risks. 11 figs. (author)

Automated derivation of failure symptoms for diagnosis of nuclear plant

International Nuclear Information System (INIS)

Washio, T.; Kitamura, M.; Kotajima, K.; Sugiyama, K.

1986-01-01

A method of automated derivation of failure symptoms was developed as an approach to computer-aided failure diagnosis in a nuclear power plant. The automated derivation is realized using a knowledge representation called the semantic network (S-net). The purpose of this paper is to demonstrate the applicability of the S-net representation as a basic tool for deriving failure symptoms. If one can generate symptoms automatically, the computer-aided plant safety analysis and diagnosis can be performed easily by evaluating the influence of the failures on the whole plant. A specific description format called a 'network list' was introduced to implement the knowledge of the structure of the plant. The failure symptoms are derived automatically, based on the knowledge of the structure of the plant, using a PROLOG-based database handling system. This approach allows us to derive the failure symptoms of the plant without using conventional event-chain models (e.g. a cause-consequence tree) which are subject to human errors in their design and implementation. Applicability of this method was evaluated with a simulation model of the dynamics of the secondary system of a PWR. (author)

Becoming an Officer of Consequence

Science.gov (United States)

2007-01-01

ndupress .ndu.edu   issue 44, 1st quarter 2007  /  JFQ        6 Becoming an officer of Consequence m uch of the literature about military history...commander become officers of consequence because their commanders value their judgment and seek their counsel when making difficult choices...COVERED 00-00-2007 to 00-00-2007 4. TITLE AND SUBTITLE Becoming an Officer of Consequence 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM

Simulation of high consequence areas for gas pipelines

Directory of Open Access Journals (Sweden)

Orlando Díaz-Parra

2018-01-01

Full Text Available The gas pipeline is used for the transport of natural gas at a great distance. Risks derived from the handling of a combustible material transported under high pressure, by pipelines that pass close to where people live, makes it necessary to adopt prevention, mitigation and control measures to reduce the effect in case of ignition of a gas leak. This work shows the development of a new mathematical model to determine areas of high consequence and their application, using widely available and easy to use software, such as Google Earth and Excel, to determine and visualize the area up to which the level of radiation can affect the integrity of people and buildings. The model takes into account the pressure drop into the gas pipeline from the compression station, the gas leakage rate and possible forms of gas ignition. This development is an alternative to the use of specialized software and highly trained personnel. The simulation is applied to a traced of the Miraflores-Tunja gas pipeline, using a macro developed in Excel to determine the impact area and compare it with the coordinates of the vulnerable areas. The zones where these areas intersect are constituted in high consequence areas and are identified along with the sections of the pipeline that affect them, to provide the operator with a risk analysis tool for the determination and visualization of the gas pipeline and its environment.

Possible consequences of nuclear war

International Nuclear Information System (INIS)

Anon.

1986-01-01

Speeches of Soviet and foreign scientists at the Second Section of 2d All-UNION conference of scientists on problems of peace and prevention of nuclear war related to possible consequences of nuclear war have been considered. It is noted that production of a large amount of aerosol particles, dust, smoke and combustion products due to forest-fires, fires in cities, which change considerably atmosphere properties, will be the greatest effect of nuclear strike from the point of view of global consequencies. ''Nuclear winter'', photosynthesis suppression, plant bioproductivity weakening, long-term climate changes, ozone layer disturbance, mass and irreversible degeneration of all biosphere on the whole are great consequencies of nuclear conflict. Attention is paid to medical service, industrial accidents, radioactive fallouts consequence of radiation and other harmful factors for people in nuclear war

Dimensional reduction of 10d heterotic string effective lagrangian with higher derivative terms

International Nuclear Information System (INIS)

Lalak, Z.; Pawelczyk, J.

1989-11-01

Dimensional reduction of the 10d Supergravity-Yang-Mills theories containing up to four derivatives is described. Unexpected nondiagonal corrections to 4d gauge kinetic function and negative contributions to scalar potential are found. We analyzed the general structure of the resulting lagrangian and discuss the possible phenomenological consequences. (author)

Consequence analysis

International Nuclear Information System (INIS)

Woodard, K.

1985-01-01

The objectives of this paper are to: Provide a realistic assessment of consequences; Account for plant and site-specific characteristics; Adjust accident release characteristics to account for results of plant-containment analysis; Produce conditional risk curves for each of five health effects; and Estimate uncertainties

Platelet-Derived Microvesicles in Cardiovascular Diseases

Directory of Open Access Journals (Sweden)

Maria T. K. Zaldivia

2017-11-01

Full Text Available Microvesicles (MVs circulating in the blood are small vesicles (100–1,000 nm in diameter derived from membrane blebs of cells such as activated platelets, endothelial cells, and leukocytes. A growing body of evidence now supports the concept that platelet-derived microvesicles (PMVs, the most abundant MVs in the circulation, are important regulators of hemostasis, inflammation, and angiogenesis. Compared with healthy individuals, a large increase of circulating PMVs has been observed, particularly in patients with cardiovascular diseases. As observed in MVs from other parent cells, PMVs exert their biological effects in multiple ways, such as triggering various intercellular signaling cascades and by participating in transcellular communication by the transfer of their “cargo” of cytoplasmic components and surface receptors to other cell types. This review describes our current understanding of the potential role of PMVs in mediating hemostasis, inflammation, and angiogenesis and their consequences on the pathogenesis of cardiovascular diseases, such as atherosclerosis, myocardial infarction, and venous thrombosis. Furthermore, new developments of the therapeutic potential of PMVs for the treatment of cardiovascular diseases will be discussed.

Jellyfish blooms in China: Dominant species, causes and consequences

International Nuclear Information System (INIS)

Dong Zhijun; Liu Dongyan; Keesing, John K.

2010-01-01

Three jellyfish species, Aurelia aurita, Cyanea nozakii and Nemopilema nomurai, form large blooms in Chinese seas. We report on the distribution and increasing incidence of jellyfish blooms and their consequences in Chinese coastal seas and analyze their relationship to anthropogenically derived changes to the environment in order to determine the possible causes. A. aurita, C. nozakii and N. nomurai form blooms in the temperate Chinese seas including the northern East China Sea, Yellow Sea and Bohai Sea. N. nomurai forms offshore blooms while the other two species bloom mainly in inshore areas. Eutrophication, overfishing, habitat modification for aquaculture and climate change are all possible contributory factors facilitating plausible mechanisms for the proliferation of jellyfish blooms. In the absence of improvement in coastal marine ecosystem health, jellyfish blooms could be sustained and may even spread from the locations in which they now occur.

Criminological problems of studying crime consequences

Directory of Open Access Journals (Sweden)

Sabitov R.A.

2014-12-01

Full Text Available The phenomenon of crime consequences is studied as a total social and not social, direct and indirect damage caused by crime. The quantitative and qualitative indicators of these consequences are shown. It is determined that concept of crime does not embrace its consequences and victims. The qualitative indicators of crime consequences imply the consequences’ character and structure; the quantitative indicators imply cumulative consequences of certain kinds of crime, the dynamics of certain kinds of consequences and coefficient of certain crime consequences. It is proved that not only physical and juridical persons, but also the public, authorities and associations (groups of people having no indication of juridical person must be recognized as crime sufferers. It is argued that crimes can cause property and moral damage (goodwill damage, ecological damage, considerable damage of interests protected by the law, information, managerial damage and other kinds of damage. Theoretically according to criminal law a crime sufferer is a physical, juridical person, an authority, the public, group of people who suffered from physical, property, moral or other kind of damage caused by a completed or uncompleted crime. The author proves the necessity to fix the concept of crime sufferer in criminal law. The concept of victim should include Russian criminal actualities, foreign experience and embrace not only physical but also juridical persons and groups of people suffered from crimes.

Consequences of Diffusion of Innovations.

Science.gov (United States)

Goss, Kevin F.

1979-01-01

The article traces evolution of diffusion theory; illustrates undesirable consequences in a cross-cultural setting, reviews criticisms of several scholars; considers distributional effects and unanticipated consequences for potential ameliorative impact on diffusion theory; and codifies these factors into a framework for research into consequences…

Biologic consequences of Stat1-independent IFN signaling

Science.gov (United States)

Gil, M. Pilar; Bohn, Erwin; O'Guin, Andrew K.; Ramana, Chilakamarti V.; Levine, Beth; Stark, George R.; Virgin, Herbert W.; Schreiber, Robert D.

2001-01-01

Although Stat1 is required for many IFN-dependent responses, recent work has shown that IFNγ functions independently of Stat1 to affect the growth of tumor cells or immortalized fibroblasts. We now demonstrate that both IFNγ and IFNα/β regulate proliferative responses in cells of the mononuclear phagocyte lineage derived from Stat1-null mice. Using both representational difference analysis and gene arrays, we show that IFNγ exerts its Stat1-independent actions on mononuclear phagocytes by regulating the expression of many genes. This result was confirmed by monitoring changes in expression and function of the corresponding gene products. Regulation of the expression of these genes requires the IFNγ receptor and Jak1. The physiologic relevance of IFN-dependent, Stat1-independent signaling was demonstrated by monitoring antiviral responses in Stat1-null mice. Thus, the IFN receptors engage alternative Stat1-independent signaling pathways that have important physiological consequences. PMID:11390995

The Consequences of School Desegregation.

Science.gov (United States)

Rossell, Christine H., Ed.; Hawley, Willis D., Ed.

Materials on a variety of subjects related to school desegregation are collected in this book. Chapter 1 discusses assumptions about the overall consequences of desegregation. Chapters 2 to 5 synthesize the findings of existing research on the consequences of school desegregation for children and communities. Finally, Chapter 6 describes…

Institutional Consequences of Quality Assessment

Science.gov (United States)

Joao Rosa, Maria; Tavares, Diana; Amaral, Alberto

2006-01-01

This paper analyses the opinions of Portuguese university rectors and academics on the quality assessment system and its consequences at the institutional level. The results obtained show that university staff (rectors and academics, with more of the former than the latter) held optimistic views of the positive consequences of quality assessment…

Clinical impact of the immunome in lymphoid malignancies: the role of Myeloid-Derived Suppressor Cells

Directory of Open Access Journals (Sweden)

Calogero eVetro

2015-05-01

Full Text Available The better definition of the mutual sustainment between neoplastic cells and immune system has been translated from the bench to the bedside acquiring value as prognostic factor. Additionally, it represents a promising tool for improving therapeutic strategies. In this context, myeloid-derived suppressor cells have gained a central role in tumor developing with consequent therapeutic implications. In this review, we will focus on the biological and clinical impact of the study of myeloid-derived suppressor cells in the settings of lymphoid malignancies.

The consequences of "Culture's consequences"

DEFF Research Database (Denmark)

Knudsen, Fabienne; Froholdt, Lisa Loloma

2009-01-01

  In this article, it is claimed that research on cross-cultural crews is dominated by one specific understanding of the concept of culture, which is static, evenly distributed and context-independent. Such a conception of culture may bring some basic order while facing an unknown culture...... review of the theory of Geert Hofstede, the most renowned representative of this theoretical approach. The practical consequences of using such a concept of culture is then analysed by means of a critical review of an article applying Hofstede to cross-cultural crews in seafaring. Finally, alternative...... views on culture are presented. The aim of the article is, rather than to promote any specific theory, to reflect about diverse perspectives of cultural sense-making in cross-cultural encounters. Udgivelsesdato: Oktober...

Removal of boron(III) by N-methylglucamine-type cellulose derivatives with higher adsorption rate

International Nuclear Information System (INIS)

Inukai, Yoshinari; Tanaka, Yoshiharu; Matsuda, Toshio; Mihara, Nobutake; Yamada, Kouji; Nambu, Nobuyoshi; Itoh, Osamu; Doi, Takao; Kaida, Yasuhiko; Yasuda, Seiji

2004-01-01

To obtain adsorbents for boron(III) derived from a natural polymer, two forms (powder and fiber) of N-methylglucamine-type cellulose derivatives were newly synthesized. After the graft polymerization of two forms of cellulose with vinyl monomer having epoxy groups, the N-methylglucamine-type cellulose derivatives were obtained by the reaction of the grafted cellulose with N-methylglucamine. The adsorption capacities of the cellulose derivatives for boron(III) were the same levels as that of a commercially available N-methylglucamine-type polystyrene resin. However, the cellulose derivatives adsorbed boron(III) more quickly than the polystyrene resin. The adsorption and desorption of boron(III) with a column method using the cellulose fiber were achieved at a higher flow rate than that using the polystyrene resin. In addition, the boron(III), adsorbed on the cellulose fiber column, was quantitatively recovered with dilute hydrochloric acid in 20- and 200-fold increased concentrations. Consequently, it was found that the cellulose derivatives were superior to the polystyrene resin as adsorbents for boron(III) for treatment of a large quantity of wastewater

Climate impacts on hydropower and consequences for global electricity supply investment needs

Energy Technology Data Exchange (ETDEWEB)

Turner, Sean W. D.; Hejazi, Mohamad; Kim, Son H.; Clarke, Leon; Edmonds, Jae

2017-12-01

Recent progress in global scale hydrological and dam modeling has allowed for the study of climate change impacts on global hydropower production. Here we explore the possible consequences of these impacts for the electricity supply sector. Regional hydropower projections are developed for two emissions scenarios by forcing a coupled global hydrological and dam model with downscaled, bias-corrected climate realizations derived from sixteen general circulation models. Consequent impacts on power sector composition and associated emissions and investment costs are explored using the Global Change Assessment Model (GCAM). Changes in hydropower generation resulting from climate change can shift power demands onto and away from carbon intensive technologies, resulting in significant impacts on power sector CO2 emissions for certain world regions—primarily those located in Latin America, as well as Canada and parts of Europe. Reduced impacts of climate change on hydropower production under a low emissions scenario coincide with increased costs of marginal power generating capacity—meaning impacts on power sector investment costs are similar for high and low emissions scenarios. Individual countries where impacts on investment costs imply significant risks or opportunities are identified.

Development and introduction of inactivated poliovirus vaccines derived from Sabin strains in Japan.

Science.gov (United States)

Shimizu, Hiroyuki

2016-04-07

During the endgame of global polio eradication, the universal introduction of inactivated poliovirus vaccines is urgently required to reduce the risk of vaccine-associated paralytic poliomyelitis and polio outbreaks due to wild and vaccine-derived polioviruses. In particular, the development of inactivated poliovirus vaccines (IPVs) derived from the attenuated Sabin strains is considered to be a highly favorable option for the production of novel IPV that reduce the risk of facility-acquired transmission of poliovirus to the communities. In Japan, Sabin-derived IPVs (sIPVs) have been developed and introduced for routine immunization in November 2012. They are the first licensed sIPVs in the world. Consequently, trivalent oral poliovirus vaccine was used for polio control in Japan for more than half a century but has now been removed from the list of vaccines licensed for routine immunization. This paper reviews the development, introduction, characterization, and global status of IPV derived from attenuated Sabin strains. Copyright © 2014 Elsevier Ltd. All rights reserved.

Accident consequence assessment code development

International Nuclear Information System (INIS)

Homma, T.; Togawa, O.

1991-01-01

This paper describes the new computer code system, OSCAAR developed for off-site consequence assessment of a potential nuclear accident. OSCAAR consists of several modules which have modeling capabilities in atmospheric transport, foodchain transport, dosimetry, emergency response and radiological health effects. The major modules of the consequence assessment code are described, highlighting the validation and verification of the models. (author)

Phenomenological consequences of supersymmetry

International Nuclear Information System (INIS)

Hinchliffe, I.; Littenberg, L.

1982-01-01

This report deals with the phenomenological consequences of supersymmetric theories, and with the implications of such theories for future high energy machines. It is concerned only with high energy predictions of supersymmetry; low energy consequences (for example in the K/sub o/anti K/sub o/ system) are discussed in the context of future experiments by another group, and will be mentioned briefly only in the context of constraining existing models. However a brief section is included on the implication for proton decay, although detailed experimental questions are not discussed. The report is organized as follows. Section I consists of a brief review of supersymmetry and the salient features of existing supersymmetric models; this section can be ignored by those familiar with such models since it contains nothing new. Section 2 deals with the consequences for nucleon decay of SUSY. The remaining sections then discuss the physics possibilities of various machines; e anti e in Section 3, ep in Section 4, pp (or anti pp) colliders in Section 5 and fixed target hadron machines in Section 6

Analysis of uncertainties caused by the atmospheric dispersion model in accident consequence assessments with UFOMOD

International Nuclear Information System (INIS)

Fischer, F.; Ehrhardt, J.

1988-06-01

Various techniques available for uncertainty analysis of large computer models are applied, described and selected as most appropriate for analyzing the uncertainty in the predictions of accident consequence assessments. The investigation refers to the atmospheric dispersion and deposition submodel (straight-line Gaussian plume model) of UFOMOD, whose most important input variables and parameters are linked with probability distributions derived from expert judgement. Uncertainty bands show how much variability exists, sensitivity measures determine what causes this variability in consequences. Results are presented as confidence bounds of complementary cumulative frequency distributions (CCFDs) of activity concentrations, organ doses and health effects, partially as a function of distance from the site. In addition the ranked influence of the uncertain parameters on the different consequence types is shown. For the estimation of confidence bounds it was sufficient to choose a model parameter sample size of n (n=59) equal to 1.5 times the number of uncertain model parameters. Different samples or an increase of sample size did not change the 5%-95% - confidence bands. To get statistically stable results of the sensitivity analysis, larger sample sizes are needed (n=100, 200). Random or Latin-hypercube sampling schemes as tools for uncertainty and sensitivity analyses led to comparable results. (orig.) [de

Investigation of some characteristics of polyhydroxy milkweed triglycerides and their acylated derivatives in relation to lubricity

Science.gov (United States)

Most industrial lubricants are derived from non-renewable petroleum-based sources. As useful as these lubricants are, their unintended consequences are the pollution of our environment as a result of the very slow degradation of the spent materials. Native seed oils, on the other hand, are renewa...

Supraclassical consequence relations: Tolerating rare counterexamples

CSIR Research Space (South Africa)

Labuschagne, W

2013-12-01

Full Text Available We explore a family of supraclassical consequence relations obtained by varying the criteria according to which counterexamples to classical entailment may be deemed tolerable. This provides a different perspective on the rational consequence...

Adolescent childbearing: consequences and interventions.

Science.gov (United States)

Ruedinger, Emily; Cox, Joanne E

2012-08-01

Adolescent childbearing in the United States continues to occur at high rates compared with other industrialized nations, despite a recent decline. Adolescent mothers and their offspring are at risk for negative outcomes. Recent literature exploring the consequences of teenage childbearing and interventions to ameliorate these consequences are presented. Negative consequences of adolescent childbearing can impact mothers and their offspring throughout the lifespan. These consequences are likely attributable to social and environmental factors rather than solely to maternal age. Increasing educational attainment, preventing repeat pregnancy and improving mother-child interactions can improve outcomes for mothers and their children. Home, community, school and clinic-based programs are all viable models of service delivery to this population. Connecting teen mothers with comprehensive services to meet their social, economic, health and educational needs can potentially improve long-term outcomes for both mothers and their offspring. Programs that deliver care to this population in culturally sensitive, developmentally appropriate ways have demonstrated success. Future investigation of parenting interventions with larger sample sizes and that assess multiple outcomes will allow comparison among programs. Explorations of the role of the father and coparenting are also directions for future research.

The gauge properties of the dual model pomeron-reggeon vertex their derivation and their consequences

CERN Document Server

Brink, L; Scherk, J

1973-01-01

Study of the non-planar orientable single dual loop diagrams in 26 space-time dimensions has revealed an infinite positive-definite spectrum of 'pomeron' intermediate states which couple to reggeons via a bilinear pomeron-reggeon vertex operator. General algebraic techniques are developed to derive the behaviour of this vertex with respect to the Visasoro gauge operators. A reflection and transmission behaviour is found, reminiscent of the behaviour of a wave incident at the interface between two different media (in this case reggeonic and pomeronic). These gauge properties are such as to guarantee the desired 'good properties', namely completeness of the transverse reggeon states when coupled between physical reggeon states on one side, and on the other side, either physical pomeron states or else physical reggeon states created via an intermediate pomeron. This is yet another example of the amazing and gratifying self-consistency of the dual model with respect to duality, transversality and unitarity. (13 r...

Fluorescein Derivatives in Intravital Fluorescence Imaging

Directory of Open Access Journals (Sweden)

Michael S. Roberts

2013-08-01

Full Text Available Intravital fluorescence microscopy enables the direct imaging of fluorophores in vivo and advanced techniques such as fluorescence lifetime imaging (FLIM enable the simultaneous detection of multiple fluorophores. Consequently, it is now possible to record distribution and metabolism of a chemical in vivo and to optimise the delivery of fluorophores in vivo. Recent clinical applications with fluorescein and other intravital fluorescent stains have occurred in neurosurgery, dermatology [including photodynamic therapy (PDT] and endomicroscopy. Potential uses have been identified in periodontal disease, skin graft and cancer surgery. Animal studies have demonstrated that diseased tissue can be specifically stained with fluorophore conjugates. This review focuses on the fluorescein derived fluorophores in common clinical use and provides examples of novel applications from studies in tissue samples.

Phenomenological consequences of supersymmetry

International Nuclear Information System (INIS)

Hinchliffe, I.; Littenberg, L.

1982-01-01

This paper deals with the phenomenological consequences of supersymmetric theories, and with the implications of such theories for future high energy machines. The paper represents the work of a subgroup at the meeting. The authors are concerned only with high energy predictions of supersymmetry; low energy consequences (for example in the K/sub o/K-bar/sub o/ system) are discussed in the context of future experiments by another group, and will be mentioned briefly only in the context of constraining existing models. However a brief section is included on the implication for proton decay, although detailed experimental questions are not discussed

Assessing economic consequences of radiation accidents

International Nuclear Information System (INIS)

Rowe, M.D.; Lee, J.C.; Grimshaw, C.A.; Kalb, P.D.

1987-01-01

A recent review of existing models and methods for assessing potential consequences of accidents in the high-level radioactive waste (HLW) disposal system identifies economic consequence assessment methods as a weak point. Existing methods have mostly been designed to assess economic consequences of reactor accidents, the possible scale of which can be several orders of magnitude greater than anything possible in the HLW disposal system. There is therefore some question about the applicability of these methods, their assumptions, and their level of detail to assessments of smaller accidents. The US Dept. of Energy funded this study to determine needs for code modifications or model development for assessing economic costs of accidents in the HLW disposal system. The objectives of the study were as follows: (1) review the literature on economic consequences of accidents to determine the availability of assessment methods and data and their applicability to the HLW disposal system before closure. (2) Determine needs for expansion, revision, or adaptation of methods and data for modeling economic consequences of accidents of the scale projected for the disposal system. (3) Gather data that might be useful for the needed revisions for modeling economic impacts on this scale

Consequence Reasoning in Multilevel Flow Modelling

DEFF Research Database (Denmark)

Zhang, Xinxin; Lind, Morten; Ravn, Ole

2013-01-01

Consequence reasoning is a major element for operation support system to assess the plant situations. The purpose of this paper is to elaborate how Multilevel Flow Models can be used to reason about consequences of disturbances in complex engineering systems. MFM is a modelling methodology...... for representing process knowledge for complex systems. It represents the system by using means-end and part-whole decompositions, and describes not only the purposes and functions of the system but also the causal relations between them. Thus MFM is a tool for causal reasoning. The paper introduces MFM modelling...... syntax and gives detailed reasoning formulas for consequence reasoning. The reasoning formulas offers basis for developing rule-based system to perform consequence reasoning based on MFM, which can be used for alarm design, risk monitoring, and supervision and operation support system design....

Drinking Water Consequences Tools. A Literature Review

Energy Technology Data Exchange (ETDEWEB)

Pasqualini, Donatella [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

2016-05-12

In support of the goals of Department of Homeland Security’s (DHS) National Protection and Programs Directorate and the Federal Emergency Management Agency, the DHS Office of Science and Technology is seeking to develop and/or modify consequence assessment tools to enable drinking water systems owner/operators to estimate the societal and economic consequences of drinking water disruption due to the threats and hazards. This work will expand the breadth of consequence estimation methods and tools using the best-available data describing water distribution infrastructure, owner/assetlevel economic losses, regional-scale economic activity, and health. In addition, this project will deploy the consequence methodology and capability within a Web-based platform. This report is intended to support DHS effort providing a review literature review of existing assessment tools of water and wastewater systems consequences to disruptions. The review includes tools that assess water systems resilience, vulnerability, and risk. This will help to understand gaps and limitations of these tools in order to plan for the development of the next-generation consequences tool for water and waste water systems disruption.

Functional characterization of cytochrome P450-derived epoxyeicosatrienoic acids in adipogenesis and obesity.

Science.gov (United States)

Zha, Weibin; Edin, Matthew L; Vendrov, Kimberly C; Schuck, Robert N; Lih, Fred B; Jat, Jawahar Lal; Bradbury, J Alyce; DeGraff, Laura M; Hua, Kunjie; Tomer, Kenneth B; Falck, John R; Zeldin, Darryl C; Lee, Craig R

2014-10-01

Adipogenesis plays a critical role in the initiation and progression of obesity. Although cytochrome P450 (CYP)-derived epoxyeicosatrienoic acids (EETs) have emerged as a potential therapeutic target for cardiometabolic disease, the functional contribution of EETs to adipogenesis and the pathogenesis of obesity remain poorly understood. Our studies demonstrated that induction of adipogenesis in differentiated 3T3-L1 cells (in vitro) and obesity-associated adipose expansion in high-fat diet (HFD)-fed mice (in vivo) significantly dysregulate the CYP epoxygenase pathway and evoke a marked suppression of adipose-derived EET levels. Subsequent in vitro experiments demonstrated that exogenous EET analog administration elicits potent anti-adipogenic effects via inhibition of the early phase of adipogenesis. Furthermore, EET analog administration to mice significantly mitigated HFD-induced weight gain, adipose tissue expansion, pro-adipogenic gene expression, and glucose intolerance. Collectively, these findings suggest that suppression of EET bioavailability in adipose tissue is a key pathological consequence of obesity, and strategies that promote the protective effects of EETs in adipose tissue offer enormous therapeutic potential for obesity and its downstream pathological consequences. Copyright © 2014 by the American Society for Biochemistry and Molecular Biology, Inc.

Photochemical reduction of water-soluble C60 derivatives (EPR study)

International Nuclear Information System (INIS)

Brezova, V.; Stasko, A.; Dvoranova, D.; Asmus, K.D.; Guldi, D.M.

1999-01-01

The photochemical reduction of three bis-functionalized C 60 derivatives resulted in the formation of a single radical product, characterized by relatively narrow EPR line (g M = 2.0007, pp < 0.02 mT). In the irradiated aqueous solutions containing L-ascorbic acid, in the addition to the EPR line related to bis-adduct mono-anion, also 6-line EPR spectrum of ascorbyl radical was observed. Consequently, the photoinduced formation of ascorbyl radical was attributed to the intermolecular quenching of fullerenes excited states. (authors)

Choices and Consequences.

Science.gov (United States)

Thorp, Carmany

1995-01-01

Describes student use of Hyperstudio computer software to create history adventure games. History came alive while students learned efficient writing skills; learned to understand and manipulate cause, effect choice and consequence; and learned to incorporate succinct locational, climatic, and historical detail. (ET)

Demographic Consequences of Defeating Aging

OpenAIRE

Gavrilov, Leonid A.; Gavrilova, Natalia S.

2010-01-01

A common objection against starting a large-scale biomedical war on aging is the fear of catastrophic population consequences (overpopulation). This fear is only exacerbated by the fact that no detailed demographic projections for radical life extension scenario have been conducted so far. This study explores different demographic scenarios and population projections, in order to clarify what could be the demographic consequences of a successful biomedical war on aging. A general conclusion o...

Individual consequences of having work and family roles simultaneously in Iranian married women.

Science.gov (United States)

Taghizadeh, Ziba; Ebadi, Abbas; Mohammadi, Eesa; Pourreza, Abolghasem; Kazemnejad, Anoshirvan; Bagherzadeh, Razieh

2017-01-01

Because of the paucity of studies about the consequences of women's work and family responsibilities in Iran, in the present study the authors used a qualitative approach to begin to provide in-depth answers to the following question: What are the consequences of having work and family responsibilities in Iranian married women? Data were obtained from 29 participants using individual in-depth interviews conducted with 17 participants in addition to two focus groups (n = 6 per group), all conducted in the second half of 2014. All of the participants were Iranian nationals, married, and held a full-time job outside the home. Five main themes were derived from the study: "promotion of self-esteem and social status," "facing difficulties," "effort and dedication," "unfulfilled needs and non-optimal health," and "restless mind." Participants reported achieving a number of advantages for themselves and their families as a result of working outside the home; but, they also had many problems with the potential to impair various health aspects, including physical, reproductive, and mental health. Thus, it is important for Iranian health-care providers to consider the effect of the work-family interference on women.

Evolutionary impact assessment: Accounting for the evolutionary consequences of fishing in an ecosystem approach to fisheries management

DEFF Research Database (Denmark)

Laugen, Ane T.; Engelhard, Georg H.; Whitlock, Rebecca

2014-01-01

substantial scientific attention recently is fisheries-induced evolution (FIE). Increasing evidence indicates that intensive fishing has the potential to exert strong directional selection on life-history traits, behaviour, physiology, and morphology of exploited fish. Of particular concern is that reversing...... evolutionary responses to fishing can be much more difficult than reversing demographic or phenotypically plastic responses. Furthermore, like climate change, multiple agents cause FIE, with effects accumulating over time. Consequently, FIE may alter the utility derived from fish stocks, which in turn can...

Comparison of tropical and temperate freshwater animal species' acute sensitivities to chemicals: implications for deriving safe extrapolation factors

NARCIS (Netherlands)

Kwok, K.W.H.; Leung, K.M.Y.; Lui, G.S.G.; Chu, V.K.H.; Lam, P.K.S.; Morritt, D.; Maltby, L.; Brock, T.C.M.; Brink, van den P.J.; Warne, M.S.J.; Crane, M.

2007-01-01

Toxicity data for tropical species are often lacking for ecological risk assessment. Consequently, tropical and subtropical countries use water quality criteria (WQC) derived from temperate species (e.g., United States, Canada, or Europe) to assess ecological risks in their aquatic systems, leaving

Comments on a derivation and application of the 'maximum entropy production' principle

International Nuclear Information System (INIS)

Grinstein, G; Linsker, R

2007-01-01

We show that (1) an error invalidates the derivation (Dewar 2005 J. Phys. A: Math. Gen. 38 L371) of the maximum entropy production (MaxEP) principle for systems far from equilibrium, for which the constitutive relations are nonlinear; and (2) the claim (Dewar 2003 J. Phys. A: Math. Gen. 36 631) that the phenomenon of 'self-organized criticality' is a consequence of MaxEP for slowly driven systems is unjustified. (comment)

40 CFR 68.22 - Offsite consequence analysis parameters.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 15 2010-07-01 2010-07-01 false Offsite consequence analysis... PROGRAMS (CONTINUED) CHEMICAL ACCIDENT PREVENTION PROVISIONS Hazard Assessment § 68.22 Offsite consequence analysis parameters. (a) Endpoints. For analyses of offsite consequences, the following endpoints shall be...

Pion-nucleon charge-exchange polarization by Gribov Reggeon calculus and the derivative rule

International Nuclear Information System (INIS)

Ardill, R.W.B.; Koehler, P.; Moriarty, K.J.M.

1977-01-01

The phenomenological consequences of the Gribov Reggeon calculus for the reaction πsup(-)+p→πdeg+n at 6 GeV/c are investigated and the polarization is obtained. The derivative rules is used to calculate the helicity flip amplitude. The results are very encouraging and would seem to indicate that the Gribov Reggeon calculus can be considered a more satisfactory approach to two-body phenomenology than the absorption model

General Logic-Systems and Consequence Operators

OpenAIRE

Herrmann, Robert A.

2005-01-01

In this paper, general logic-systems are investigated. It is shown that there are infinitely many finite consequence operators defined on a fixed language L that cannot be generated from a finite logic-system. It is shown that a set map is a finite consequence operator iff it is defined by a general logic-system.

Psychological consequences caused by nuclear terrorism

International Nuclear Information System (INIS)

Peyankov, I.

2009-01-01

The psychological consequences caused by eventual nuclear terrorist act are believed to be some of the most: serious. in this article are presented the issues concerning psychological effects as psychological suffering, alteration of risk estimation, changes of individual and social behavior, etc. The most common psychological consequences as a result of the most popular large-scale nuclear accidents in Chernobyl, TMI (USA), Goiania (Brazil) are described. Some of the main factors, such as sex, age, health status, social status and etc, are analyzed. These factors determine the expression of psychological reactions provoked by nuclear accidents or eventual act of nuclear terrorism. In addition, the main precautions to cope with psychological consequences caused by nuclear terrorism are listed

On categorical approach to derived preference relations in some decision making problems

OpenAIRE

Rozen, Victor V.; Zhitomirski, Grigori

2005-01-01

A structure called a decision making problem is considered. The set of outcomes (consequences) is partially ordered according to the decision maker's preferences. The problem is how these preferences affect a decision maker to prefer one of his strategies (or acts) to another, i.e. it is to describe so called derived preference relations. This problem is formalized by using category theory approach and reduced to a pure algebraical question. An effective method is suggested to build all reaso...

Direct phase derivative estimation using difference equation modeling in holographic interferometry

International Nuclear Information System (INIS)

Kulkarni, Rishikesh; Rastogi, Pramod

2014-01-01

A new method is proposed for the direct phase derivative estimation from a single spatial frequency modulated carrier fringe pattern in holographic interferometry. The fringe intensity in a given row/column is modeled as a difference equation of intensity with spatially varying coefficients. These coefficients carry the information on the phase derivative. Consequently, the accurate estimation of the coefficients is obtained by approximating the coefficients as a linear combination of the predefined linearly independent basis functions. Unlike Fourier transform based fringe analysis, the method does not call for performing the filtering of the Fourier spectrum of fringe intensity. Moreover, the estimation of the carrier frequency is performed by applying the proposed method to a reference interferogram. The performance of the proposed method is insensitive to the fringe amplitude modulation and is validated with the simulation results. (paper)

Human atopic dermatitis skin-derived T cells can induce a reaction in mouse keratinocytes in vivo

DEFF Research Database (Denmark)

Martel, Britta C; Blom, Lars; Dyring-Andersen, Beatrice

2015-01-01

. In comparison, blood -derived in vitro differentiated Th2 cells only induced a weak response in a few of the mice. Thus, we conclude that human AD skin-derived T cells can induce a reaction in mouse skin through induction of a proliferative response in the mouse keratinocytes. This article is protected......In atopic dermatitis (AD), the inflammatory response between skin infiltrating T cells and keratinocytes is fundamental to the development of chronic lesional eczema. The aim of this study was to investigate whether skin-derived T cells from AD patients could induce an inflammatory response in mice...... through keratinocyte activation and consequently cause development of eczematous lesions. Punch biopsies of lesional skin from AD patients were used to establish skin-derived T cell cultures and which were transferred into NOD.Cg-Prkd(scid) Il2rg(tm1Sug) /JicTac (NOG) mice. We found that subcutaneous...

Different drinking motives, different adverse consequences?

DEFF Research Database (Denmark)

Wicki, Matthias; Kuntsche, Emmanuel; Eichenberger, Yvonne

2017-01-01

INTRODUCTION AND AIM: This study, which builds on previous research demonstrating that drinking motives are associated with adverse consequences, investigates the associations between drinking motives and non-alcohol-attributed adverse consequences and disentangles alcohol-related and direct......, differences across countries were tested in a multigroup analysis. RESULTS: The indirect effect (via alcohol use) was greater for injuries and academic problems than for more general outcomes such as life dissatisfaction and negative body image. For social, enhancement and coping motives, we found positive...... indirect effects (via alcohol use) on injuries and academic problems; the association was negative for conformity motives. The direct effect, that is, the effect above and beyond alcohol use, indicated more negative consequences among those who tended to drink more frequently for coping motives. More...

Therapeutic Potential of Mesenchymal Stem Cell-Derived Exosomes in the Treatment of Eye Diseases.

Science.gov (United States)

Harrell, C Randall; Simovic Markovic, Bojana; Fellabaum, Crissy; Arsenijevic, Aleksandar; Djonov, Valentin; Arsenijevic, Nebojsa; Volarevic, Vladislav

2018-05-18

Mesenchymal stem cells (MSCs) were, due to their immunomodulatory and pro-angiogenic characteristics, extensively explored as new therapeutic agents in cell-based therapy of uveitis, glaucoma, retinal and ocular surface diseases.Since it was recently revealed that exosomes play an important role in biological functions of MSCs, herewith we summarized current knowledge about the morphology, structure, phenotype and functional characteristics of MSC-derived exosomes emphasizing their therapeutic potential in the treatment of eye diseases.MSC-derived exosomes were as efficient as transplanted MSCs in limiting the extent of eye injury and inflammation. Immediately after intravitreal injection, MSC-derived exosomes, due to nano-dimension, diffused rapidly throughout the retina and significantly attenuated retinal damage and inflammation. MSC-derived exosomes successfully delivered trophic and immunomodulatory factors to the inner retina and efficiently promoted survival and neuritogenesis of injured retinal ganglion cells. MSC-derived exosomes efficiently suppressed migration of inflammatory cells, attenuated detrimental Th1 and Th17 cell-driven immune response and ameliorated experimental autoimmune uveitis. MSC-derived exosomes were able to fuse with the lysosomes within corneal cells, enabling delivering of MSC-derived active β-glucuronidase and consequent catabolism of accumulated glycosaminoglycans, indicating their therapeutic potential in the treatment of Mucopolysaccharidosis VII (Sly Syndrome). Importantly, beneficent effects were noticed only in animals that received MSC-derived exosomes and were not seen after therapy with fibroblasts-derived exosomes confirming specific therapeutic potential of MSCs and their products in the treatment of eye diseases.In conclusion, MSC-derived exosomes represent potentially new therapeutic agents in the therapy of degenerative and inflammatory ocular diseases.

Efficient Minimax Design of Networks without Using Derivatives

DEFF Research Database (Denmark)

Madsen, Kaj; Nielsen, Niels Ole; Schjær-Jacobsen, Hans

1975-01-01

., which makes the gradient computation by the adjoint network method or related methods rather complicated, and often numerical errors are introduced in the gradients. Consequently, the algorithm is found to be of particular relevance in optimum design of practical microwave networks. The relative...... design results. Finally, optimum broad-band design of a practical coaxial transferred-electron reflection-type amplilier is carried out by means of the proposed method. The results are supported by experimental verification.......A new minimax network optimization algorithm not requiring derivatives has been developed. It is based on successive linear approximations to the nonlinear functions defining the problem. Adequate modeling of distributed parameter circuits for optimization purposes often involves parasitic, etc...

Impact of the NCAM derived mimetic peptide plannexin on the acute cellular consequences of a status epilepticus

DEFF Research Database (Denmark)

Zellinger, Christina; Hadamitzky, Martin; Bock, Elisabeth

2011-01-01

Plannexin represents a NCAM-derived peptide mimicking trans-homophilic NCAM interaction, which proved to exert neuroprotective effects in vitro. The effect of plannexin was evaluated in a rat status epilepticus model. As expected, prolonged seizure activity resulted in a pronounced cell loss...... in hippocampal subregions. The comparison between the vehicle- and plannexin-treated animals with status epilepticus did not reveal neuroprotective effects of plannexin on mature neurons. However, treatment with plannexin partially prevented the reduction in the number of doublecortin-labeled neuronal progenitor...... cells, which was evident 48h following status epilepticus. In conclusion, the data might give first evidence that plannexin can protect immature neurons in vivo. Future studies are necessary to evaluate whether disease-modifying or preventive effects are observed in models of epileptogenesis....

Modeling atmospheric dispersion for reactor accident consequence evaluation

International Nuclear Information System (INIS)

Alpert, D.J.; Gudiksen, P.H.; Woodard, K.

1982-01-01

Atmospheric dispersion models are a central part of computer codes for the evaluation of potential reactor accident consequences. A variety of ways of treating to varying degrees the many physical processes that can have an impact on the predicted consequences exists. The currently available models are reviewed and their capabilities and limitations, as applied to reactor accident consequence analyses, are discussed

Constrained consequence

CSIR Research Space (South Africa)

Britz, K

2011-09-01

Full Text Available their basic properties and relationship. In Section 3 we present a modal instance of these constructions which also illustrates with an example how to reason abductively with constrained entailment in a causal or action oriented context. In Section 4 we... of models with the former approach, whereas in Section 3.3 we give an example illustrating ways in which C can be de ned with both. Here we employ the following versions of local consequence: De nition 3.4. Given a model M = hW;R;Vi and formulas...

40 CFR 68.165 - Offsite consequence analysis.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 15 2010-07-01 2010-07-01 false Offsite consequence analysis. 68.165 Section 68.165 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CHEMICAL ACCIDENT PREVENTION PROVISIONS Risk Management Plan § 68.165 Offsite consequence...

Tissue-Derived Extracellular Matrix Bioscaffolds: Emerging Applications in Cartilage and Meniscus Repair.

Science.gov (United States)

Monibi, Farrah A; Cook, James L

2017-08-01

Musculoskeletal injuries are a common problem in orthopedic practice. Given the long-term consequences of unaddressed cartilage and meniscal pathology, a number of treatments have been attempted to stimulate repair or to replace the injured tissue. Despite advances in orthopedic surgery, effective treatments for cartilage and meniscus injuries remain a significant clinical challenge. Tissue engineering is a developing field that aims to regenerate injured tissues with a combination of cells, scaffolds, and signals. Many natural and synthetic scaffold materials have been developed and tested for the repair and restoration of a number of musculoskeletal tissues. Among these, biological scaffolds derived from cell and tissue-derived extracellular matrix (ECM) have shown great promise in tissue engineering given the critical role of the ECM for maintaining the biological and biomechanical properties, structure, and function of native tissues. This review article presents emerging applications for tissue-derived ECM scaffolds in cartilage and meniscus repair. We examine normal ECM composition and the current and future methods for potential treatment of articular cartilage and meniscal defects with decellularized scaffolds.

An Examination of the Relationship between Consequence-Specific Normative Belief Patterns and Alcohol-Related Consequences among College Students

Science.gov (United States)

Reavy, Racheal; Cleveland, Michael J.; Mallett, Kimberly A.; Scaglione, Nichole M.; Sell, Nichole M.; Turrisi, Rob

2016-01-01

Background Research has previously identified a high-risk subgroup of college students who experience high levels of multiple and repeated alcohol-related consequences (MRC group). The purpose of this study was to examine the association between consequence-specific normative influences and experiencing multiple and repeated drinking-related consequences using a person-centered approach. Normative subgroups were identified using latent profile analysis (LPA), which were then used to predict MRC group status at 6-month follow-up. Methods First-year college student drinkers (N=2024) at a large northeastern university completed online surveys during the fall and spring semesters of their freshman year. Retention was high with 92% of invited participants completing T2, of which the MRC group accounted for 27%. Results Three student profiles were identified from LPA on T1 data: Non Permissive Parents (77%), Positive Peer and Parent Norms (20%), and Permissive Parents (3%). Logistic regression revealed that both the Positive Peer and Parent Norms and Permissive Parents profiles had significantly higher odds of MRC group membership at follow-up (1.81 and 2.78 times greater, respectively). Conclusions The results suggest value in prevention efforts that include normative beliefs about alcohol-related consequences. Further, parental norms in particular have the potential to enhance interventions, especially through direct communication of disapproval for experiencing consequences. PMID:27805274

Domestic policy consequences of new implementation models. Consequences for industrial niches; Industripolitiske konsekvenser av nye gjennomfoeringsmodeller. Konsekvenser for nisjebedriftene

Energy Technology Data Exchange (ETDEWEB)

Johannessen, T.

1995-12-31

The paper relates to the consequences of domestic policy with the focus on new implementation models used for cost reduction of offshore development projects in Norway. The paper puts the attention to the consequences from implementation models on industrial niches (subcontractors)

Subjective and Objective Work-Based Identity Consequences

NARCIS (Netherlands)

Botha, F.C.; Roodt, G.; van de Bunt-Kokhuis, S.G.M.; Jansen, P.G.W.; Roodt, G.

2015-01-01

The aim of this chapter is to provide a systematic literature review on the selected consequences of work-based identity (WI). The first section of the chapter includes the following subjective consequences: self-report measures on personal alienation, helping behaviour (H-OCB), burnout (consisting

Derived ERLs for inhalation of alpha-emitting aerorols

International Nuclear Information System (INIS)

Macdonald, H.F.

1977-01-01

Derived alpha action levels are expressed as dpm/m 3 and give the airborne concentration of an assumed mixture of α-emitters which if inhaled for a period of 4 hours would result in a dose commitment to members of the critical group in the exposed population equal to the emergency reference levels (ERLs) of dose recommended by the Medical Research Council (1975). The period of 4 hours is chosen as a realistic time during which an assessment of the severity of a release may be made and appropriate countermeasures instituted. The derived α ERLs are set with reference to the potential range of isotopic releases for a specific reactor system and in the case of gas-cooled magnox reactors, a value of 10 3 dpm/m 3 (170 Bqm -3 ) has been used. This level was based upon the lung and GI tract models originally recommended by ICRP 2 (1959:1964) and revised ERLs for the inhalation of α-emitters consequent upon the improved metabolic models subsequently proposed by the ICRP (1966:1972) are evaluated. It is shown that the derived α ERLs for irradiated magnox and AGR fuels are largely independent of the physico-chemical forms of the released material, while variations with cooling time of fuel are also discussed. In addition, the special limits imposed by the chemical toxicity of uranium when inhaled in a soluble, low enriched form are briefly outlined

Assessing economic consequences of radiation accidents

International Nuclear Information System (INIS)

Rowe, M.D.; Lee, J.C.; Grimshaw, C.A.; Kalb, P.D.

1987-01-01

This project reviewed the literature on the economic consequences of accidents to determine the availability of assessment methods and data and their applicability to the high-level radioactive waste (HLW) disposal system before closure; determined needs for expansion, revision, or adaptation of methods and data for modeling economic consequences of accidents of the scale projected for the disposal system; and gathered data that might be useful for the needed revisions. 8 refs., 1 tab

College Alcohol Beliefs and Drinking Consequences: A Multiple Mediation Analysis of Norms, Expectancies, and Willingness to Experience Drinking Consequences

Science.gov (United States)

Osberg, Timothy M.; Boyer, Amber

2018-01-01

Objective: We explored the potential mediating role of willingness to experience drinking consequences and other traditional alcohol outcome predictors (descriptive norms, injunctive norms, positive alcohol expectancies) in explaining the association between college alcohol beliefs1 (CABs) and the actual experience of drinking consequences among…

Global Derivatives

DEFF Research Database (Denmark)

Andersen, Torben Juul

approaches to dealing in the global business environment." - Sharon Brown-Hruska, Commissioner, Commodity Futures Trading Commission, USA. "This comprehensive survey of modern risk management using derivative securities is a fine demonstration of the practical relevance of modern derivatives theory to risk......" provides comprehensive coverage of different types of derivatives, including exchange traded contracts and over-the-counter instruments as well as real options. There is an equal emphasis on the practical application of derivatives and their actual uses in business transactions and corporate risk...... management situations. Its key features include: derivatives are introduced in a global market perspective; describes major derivative pricing models for practical use, extending these principles to valuation of real options; practical applications of derivative instruments are richly illustrated...

29 CFR 2570.114 - Consequences of default.

Science.gov (United States)

2010-07-01

... 29 Labor 9 2010-07-01 2010-07-01 false Consequences of default. 2570.114 Section 2570.114 Labor Regulations Relating to Labor (Continued) EMPLOYEE BENEFITS SECURITY ADMINISTRATION, DEPARTMENT OF LABOR... ERISA Section 502(c)(6) § 2570.114 Consequences of default. For 502(c)(6) civil penalty proceedings...

29 CFR 2570.134 - Consequences of default.

Science.gov (United States)

2010-07-01

... 29 Labor 9 2010-07-01 2010-07-01 false Consequences of default. 2570.134 Section 2570.134 Labor Regulations Relating to Labor (Continued) EMPLOYEE BENEFITS SECURITY ADMINISTRATION, DEPARTMENT OF LABOR... ERISA Section 502(c)(7) § 2570.134 Consequences of default. For 502(c)(7) civil penalty proceedings...

29 CFR 2570.164 - Consequences of default.

Science.gov (United States)

2010-07-01

... 29 Labor 9 2010-07-01 2010-07-01 false Consequences of default. 2570.164 Section 2570.164 Labor Regulations Relating to Labor (Continued) EMPLOYEE BENEFITS SECURITY ADMINISTRATION, DEPARTMENT OF LABOR... ERISA Section 502(c)(8) § 2570.164 Consequences of default. For 502(c)(8) civil penalty proceedings...

Greenhouse effect: analysis, incertitudes, consequences

International Nuclear Information System (INIS)

Perrier, A.

1991-01-01

A general presentation of climatic changes due to greenhouse effect with their consequences is analysed. After a schematic description of this effect a simplified atmospheric model (box model) is proposed. This model integrates the main feedback effects and quantifies them. The effects of astronomic and atmospheric factors on climatic changes are analyzed and compared with classical paleoclimatic results. This study shows the need of good global modelization to evaluate long term quantification of climatic greenhouse effects according to the main time lag of the several biospheric boxes. An overview of biologic and agronomic consequences is given to promote new research subjects and to orientate protecting and conservative biospheric actions [fr

Synthesis and antimalarial evaluation of some 4-quinazolinone derivatives based on febrifugine

Directory of Open Access Journals (Sweden)

Debanjan Sen

2010-01-01

Full Text Available A series of 2-substituted and 2,3-substituted quinazolin -4(3H-one derivatives were designed and synthesized based on the structure of febrifugine. The structures of the new compounds were confirmed by spectral analysis. The in vivo biological activity test results indicated that those compounds exhibited antimalarial activities against Plasmodium berghei in mice, at a dose of 5 mg/kg. Compared to Chloroquine and Artemisinin, these compounds have the advantages of shorter synthetic routes and consequently are highly cost effective in nature.

Hepatic steatosis : metabolic consequences

NARCIS (Netherlands)

Boer, Adriana Maria den

2006-01-01

In this thesis we focused on the causes and consequences of hepatic steatosis. Epidemiological studies in humans, as well as experimental studies in animal models, have shown an association between visceral obesity and dyslipidemia, insulin resistance and type 2 diabetes mellitus. The mechanism

Comparison of the iPCoD and DEPONS models for modelling population consequences of noise on harbour porpoises

DEFF Research Database (Denmark)

Nabe-Nielsen, Jacob; Harwood, John

Two different frameworks have been developed to assess the potential effects of noise associated with offshore renewable energy developments on harbour porpoise populations: The Interim Population Consequences of Disturbance (iPCoD) and Disturbance Effects of Noise on the Harbour Porpoise...... Population in the North Sea (DEPONS). Although both models simulate population dynamics based on the birth and survival rates of individual animals, they model survival in a different way. iPCoD uses average survival rates derived from data from North Sea animals. In the DEPONS model, survival emerges from...

Intended and unintended consequences of mandatory IFRS adoption

OpenAIRE

Brüggemann, Ulf; Hitz, Jörg-Markus; Sellhorn, Thorsten

2012-01-01

This paper discusses empirical evidence on the economic consequences of mandatory adoption of International Financial Reporting Standards (IFRS) in the European Union (EU) and provides suggestions on how future research can add to our understanding of these effects. Based on the explicitly stated objectives of the EU‟s so-called „IAS Regulation‟, we distinguish between intended and unintended consequences of mandatory IFRS adoption. Empirical research on the intended consequences generally fa...

Employment protection and the consequences for displaced workers

DEFF Research Database (Denmark)

Albæk, Karsten; van Audenrode, Marc; Browning, Martin

We compare the wage and employment consequences of a job displacement in Belgium and Denmark. These two countries both have generous unemployment insurance schemes but job protection laws vary dramatically between the two. Using comparable data we find that the incidence of displacement and the c...... and the consequences for wages are similar in the two countries. The consequences for employment are very different with Danish workers experiencing much less unemployment after a displacement...

29 CFR 2570.94 - Consequences of default.

Science.gov (United States)

2010-07-01

... 29 Labor 9 2010-07-01 2010-07-01 false Consequences of default. 2570.94 Section 2570.94 Labor Regulations Relating to Labor (Continued) EMPLOYEE BENEFITS SECURITY ADMINISTRATION, DEPARTMENT OF LABOR... ERISA Section 502(c)(5) § 2570.94 Consequences of default. For 502(c)(5) civil penalty proceedings, this...

29 CFR 2570.64 - Consequences of default.

Science.gov (United States)

2010-07-01

... 29 Labor 9 2010-07-01 2010-07-01 false Consequences of default. 2570.64 Section 2570.64 Labor Regulations Relating to Labor (Continued) EMPLOYEE BENEFITS SECURITY ADMINISTRATION, DEPARTMENT OF LABOR... ERISA Section 502(c)(2) § 2570.64 Consequences of default. For 502(c)(2) civil penalty proceedings, this...

Probabilistic Criticality Consequence Evaluation

International Nuclear Information System (INIS)

P. Gottlieb; J.W. Davis; J.R. Massari

1996-01-01

This analysis is prepared by the Mined Geologic Disposal System (MGDS) Waste Package Development (WPD) department with the objective of providing a comprehensive, conservative estimate of the consequences of the criticality which could possibly occur as the result of commercial spent nuclear fuel emplaced in the underground repository at Yucca Mountain. The consequences of criticality are measured principally in terms of the resulting changes in radionuclide inventory as a function of the power level and duration of the criticality. The purpose of this analysis is to extend the prior estimates of increased radionuclide inventory (Refs. 5.52 and 5.54), for both internal and external criticality. This analysis, and similar estimates and refinements to be completed before the end of fiscal year 1997, will be provided as input to Total System Performance Assessment-Viability Assessment (TSPA-VA) to demonstrate compliance with the repository performance objectives

[Health economic consequences of the choice of follicle stimulating hormone alternatives in IVF treatment].

Science.gov (United States)

Poulsen, Peter Bo; Højgaard, Astrid; Quartarolo, Jens Piero

2007-04-02

There is a choice between two types of hormones for stimulation of the follicles in IVF treatment - recombinant FSH and the urine-derived menotrophin. A literature review by NICE (2004) in the United Kingdom documented that the two types of hormones were equally effective and safe, which is why it was recommended to use the cheaper urine-derived hormone. Based on the EISG study (European and Israeli Study Group), the aim was to analyse the health economic consequences of the choice between the two types of hormone in IVF treatment in Denmark. In a prospective cost-effectiveness analysis (health care sector perspective), menotrophin and recombinant FSH (Gonal-F) were compared. Differences in costs were compared with differences in effects of the two alternatives. The total costs for the average patient are lower when using menotrophin compared with recombinant FSH. Furthermore, the cost per clinical pregnancy was lower with menotrophin compared with recombinant FSH hormone. Menotrophin is therefore less expensive both for the patient as well as for the health care sector. The use of menotrophin instead of recombinant FSH can result in savings of up to DKK 16 million on the drug budget--savings that could finance 1,400 additional IVF cycles. The analysis shows that urine-derived menotrophin is a cost-effective alternative to recombinant FSH with a potential for considerable savings for patients as well as the public drug budget.

International climate policy : consequences for shipping

OpenAIRE

Mæstad, Ottar; Evensen, Annika Jaersen; Mathiesen, Lars; Olsen, Kristian

2000-01-01

This report summarises the main results from the project Norwegian and international climate policy consequences for shipping. The aim of the project has been to shed light on how climate policies might affect shipping, both from the cost side and from the demand side. The project has been divided into three sub-projects, investigating the consequences of climate policies for 1. Optimal shipping operations and management 2. The competitiveness of shipping relative to land transport 3. The tra...

Resource consequences of reenrichment versus blending

International Nuclear Information System (INIS)

Owen, P.S.

1981-01-01

Many recent studies, including INFCE and NASAP, have concluded that recycling thermal reactor fuel reduces natural uranium requirements. These studies are based on a common set of assumptions concerning the method of recycling uranium, and consequently have produced quite similar results. It was assumed, however, that the residual uranium would be reenriched rather than blended with higher enriched uranium. This paper will examine several possible alternatives to reenriching residual uranium and discuss the consequences of each

Socioeconomic consequences of nuclear reactor accidents

International Nuclear Information System (INIS)

Tawil, J.J.; Callaway, J.W.; Coles, B.L.; Cronin, F.J.; Currie, J.W.; Imhoff, K.L.; Lewis, P.M.; Nesse, R.J.; Strenge, D.L.

1984-06-01

This report identifies and characterizes the off-site socioeconomic consequences that would likely result from a severe radiological accident at a nuclear power plant. The types of impacts that are addressed include economic impacts, health impacts, social/psychological impacts and institutional impacts. These impacts are identified for each of several phases of a reactor accident - from the warning phase through the post-resettlement phase. The relative importance of the impact during each accident phase and the degree to which the impact can be predicted are indicated. The report also examines the methods that are currently used for assessing nuclear reactor accidents, including development of accident scenarios and the estimating of socioeconomic accident consequences with various models. Finally, a critical evaluation is made regarding the use of impact analyses in estimating the contribution of socioeconomic consequences to nuclear accident reactor accident risk. 116 references, 7 figures, 15 tables

A methodology for overall consequence modeling in chemical industry

International Nuclear Information System (INIS)

Arunraj, N.S.; Maiti, J.

2009-01-01

Risk assessment in chemical process industry is a very important issue for safeguarding human and the ecosystem from damages caused to them. Consequence assessment is an integral part of risk assessment. However, the commonly used consequence estimation methods involve time-consuming complex mathematical models and simple assimilation of losses without considering all the consequence factors. This lead to the deterioration of quality of estimated risk value. So, the consequence modeling has to be performed in detail considering all major losses with optimal time to improve the decisive value of risk. The losses can be broadly categorized into production loss, assets loss, human health and safety loss, and environment loss. In this paper, a conceptual framework is developed to assess the overall consequence considering all the important components of major losses. Secondly, a methodology is developed for the calculation of all the major losses, which are normalized to yield the overall consequence. Finally, as an illustration, the proposed methodology is applied to a case study plant involving benzene extraction. The case study result using the proposed consequence assessment scheme is compared with that from the existing methodologies.

Assessing the Frequency and Material Consequences of Collisions with Vessels Lying at an Anchorage in Line with IALA iWrap MkII

Directory of Open Access Journals (Sweden)

Hans-Christoph Burmeister

2014-03-01

Full Text Available This paper proposes a collision model for ships underway and temporary objects as an extension to state-of-the-art maritime risk assessment like IALA iWrap MkII. It gives a brief review of frequency modeling's and consequence calculation theory as well as its applications, before it analogously derives a model to assess the risk of anchorage areas. Subsequently, its benefit is demonstrated by an example scenario.

Normative perceptions of alcohol-related consequences among college students.

Science.gov (United States)

Brett, Emma I; Leavens, Eleanor L; Miller, Mary Beth; Lombardi, Nathaniel; Leffingwell, Thad R

2016-07-01

College students in the U.S. continue to drink in hazardous ways and experience a range of alcohol-related consequences. Personalized feedback interventions (PFIs), which often include normative components comparing personal drinking to that of similar peers, have been effective in reducing alcohol outcomes among college students. Though normative perceptions of the quantity and frequency of alcohol use have been examined in many studies, norms for alcohol-related consequences have received less attention. The current study examined self-other discrepancies (SODs) for alcohol-related consequences among college students. Participants overestimated how often alcohol-related consequences are experienced by other same-sex students on campus and rated consequences as more acceptable for others to experience than themselves. No differences in SODs were found between those who did and did not report alcohol use. Future studies should examine the efficacy of PFIs that incorporate normative feedback on alcohol-related consequences. Copyright © 2016 Elsevier Ltd. All rights reserved.

29 CFR 2570.5 - Consequences of default.

Science.gov (United States)

2010-07-01

... 29 Labor 9 2010-07-01 2010-07-01 false Consequences of default. 2570.5 Section 2570.5 Labor... ERISA Section 502(i) § 2570.5 Consequences of default. For prohibited transaction penalty proceedings... administrative law judge may set aside a default entered under this provision where there is proof of defective...

Landscape changes as a factor affecting the course and consequences of extreme floods in the Otava river basin, Czech Republic.

Science.gov (United States)

Langhammer, Jakub; Vilímek, Vít

2008-09-01

The paper presents the analysis of anthropogenical modifications of the landscape in relation to the course and consequences of floods. The research was conducted in the Otava river basin which represents the core zone of the extreme flood in August 2002 in Central Europe. The analysis was focused on the key indicators of landscape modification potentially affecting the runoff process - the long-term changes of land-use, changes of land cover structure, land drainage, historical shortening of the river network and the modifications of streams and floodplains. The information on intensity and spatial distribution of modifications was derived from different data sources--historical maps, available GIS data, remote sensing and field mapping. The results revealed a high level of spatial diversity of anthropogenical modifications in different parts of the river basin. The intensive modifications in most of indicators were concentrated in the lowland region of the river basin due to its agricultural use; however important changes were also recorded in the headwater region of the basin. The high spatial diversity of the modifications may result in their varying effect on the course and consequences of floods in different parts of the river basin. This effect is demonstrated by the cluster analysis based on the matrix of indicators of stream and floodplain modification, physiogeographical characteristics and geomorphological evidences of the flood in August 2002, derived from the individual thematic layers using GIS.

Class differences in the social consequences of illness?

DEFF Research Database (Denmark)

Lindholm, C; Burström, B; Diderichsen, F

2002-01-01

with eight years interval 1979-89 and 1986-97. Sociodemographic characteristics, self reported longstanding illness, employment situation and financial conditions were measured at baseline. Social consequences (economic inactivity, unemployment, financial difficulties) of limiting longstanding illness were......STUDY OBJECTIVE: To investigate adverse social consequences of limiting longstanding illness and the modifying effect of socioeconomic position on these consequences. DESIGN: Cohort study on the panel within the annual Swedish Survey of Living Conditions where participants were interviewed twice...

Temporal Consequences, Message Framing, and Consideration of Future Consequences: Persuasion Effects on Adult Fruit Intake Intention and Resolve.

Science.gov (United States)

de Bruijn, Gert-Jan; Budding, Jeen

2016-08-01

Message framing is a persuasive strategy that has seen mixed evidence for promoting fruit intake intentions, potentially because framed messages for fruit intake have not (a) explicitly compared short-term consequences versus long-term consequences, (b) considered individual-level differences in time perspective, and (c) used alternative measures of fruit intake intentions. In the present online study, the effects of persuasive messages created from temporal context (short term vs. long term) and message frame (gain framed vs. loss framed) were investigated on fruit intake intentions and resolve among a sample of Dutch adults who were categorized as either present oriented or future oriented. For intention and resolve, results showed a significant Type of Frame × Type of Temporal Context interaction, such that gain-framed messages were more persuasive when combined with long-term consequences and loss-framed messages were more persuasive when combined with short-term consequences. The effect sizes for these differences were similar for resolve and intention, but only differences for intentions were significant. No other effects were found. These results demonstrate that message framing theory may usefully consider the inclusion of temporal context of outcomes and alternative motivation measures to maximize their persuasive effects.

Student Part-Time Employment: Characteristics and Consequences

Science.gov (United States)

Robotham, David

2012-01-01

Purpose: The aim of the paper is to examine the consequences of students engaging in part-time employment during their studies. It reports the results of a survey of part-time employment among university students. The research examined the possible consequences of combining part-time employment with full-time study, with particular reference to…

Workplace bullying: a tale of adverse consequences.

Science.gov (United States)

Sansone, Randy A; Sansone, Lori A

2015-01-01

Workplace bullying is defined as the repetitive and systematic engagement of interpersonally abusive behaviors that negatively affect both the targeted individual and the work organization. According to the findings of 12 studies, being bullied in the workplace affects approximately 11 percent of workers. Victims are frequently blue-collar and unskilled workers. However, there also appear to be gender and milieu/management factors. Emotional/psychological consequences of workplace bullying may include increased mental distress, sleep disturbances, fatigue in women and lack of vigor in men, depression and anxiety, adjustment disorders, and even work-related suicide. Medical consequences of workplace bullying may include an increase in health complaints such as neck pain, musculoskeletal complaints, acute pain, fibromyalgia, and cardiovascular symptoms. Finally, socioeconomic consequences of workplace bullying may include absenteeism due to sick days and unemployment. Clinicians in both mental health and primary care settings need to be alert to the associations between bullying in the workplace and these potential negative consequences, as patients may not disclose workplace maltreatment due to embarrassment or fears of retribution.

Workplace Bullying: A Tale of Adverse Consequences

Science.gov (United States)

Sansone, Lori A.

2015-01-01

Workplace bullying is defined as the repetitive and systematic engagement of interpersonally abusive behaviors that negatively affect both the targeted individual and the work organization. According to the findings of 12 studies, being bullied in the workplace affects approximately 11 percent of workers. Victims are frequently blue-collar and unskilled workers. However, there also appear to be gender and milieu/management factors. Emotional/psychological consequences of workplace bullying may include increased mental distress, sleep disturbances, fatigue in women and lack of vigor in men, depression and anxiety, adjustment disorders, and even work-related suicide. Medical consequences of workplace bullying may include an increase in health complaints such as neck pain, musculoskeletal complaints, acute pain, fibromyalgia, and cardiovascular symptoms. Finally, socioeconomic consequences of workplace bullying may include absenteeism due to sick days and unemployment. Clinicians in both mental health and primary care settings need to be alert to the associations between bullying in the workplace and these potential negative consequences, as patients may not disclose workplace maltreatment due to embarrassment or fears of retribution. PMID:25852978

Diagnosis delay in tuberculosis and its consequences

International Nuclear Information System (INIS)

Habibullah, S.; Sheikh, M.A.; Sadiq, A.; Anwar, T.

2004-01-01

Objective: To find out the average duration from onset of symptoms to the diagnosis and treatment of tuberculosis, reasons for diagnostic delay, its consequences, association of variables and formulation of recommendations. Results: In this study it was found that average time from onset of initial symptoms to diagnosis and treatment of tuberculosis was 120 days. In 64% of the patients medical practitioners were responsible for delaying the diagnosis of tuberculosis. Loss of weight in 40% and haemoptysis is 21% were the consequences of diagnostic delay of tuberculosis. Delay in the diagnosis of tuberculosis was statistically significant in those patients who consulted private practitioners, and consequences of tuberculosis were severe in those patients who consulted late. (author)

Approximate *-derivations and approximate quadratic *-derivations on C*-algebras

Directory of Open Access Journals (Sweden)

Park Choonkil

2011-01-01

Full Text Available Abstract In this paper, we prove the stability of *-derivations and of quadratic *-derivations on Banach *-algebras. We moreover prove the superstability of *-derivations and of quadratic *-derivations on C*-algebras. 2000 Mathematics Subject Classification: 39B52; 47B47; 46L05; 39B72.

New quantum codes derived from a family of antiprimitive BCH codes

Science.gov (United States)

Liu, Yang; Li, Ruihu; Lü, Liangdong; Guo, Luobin

The Bose-Chaudhuri-Hocquenghem (BCH) codes have been studied for more than 57 years and have found wide application in classical communication system and quantum information theory. In this paper, we study the construction of quantum codes from a family of q2-ary BCH codes with length n=q2m+1 (also called antiprimitive BCH codes in the literature), where q≥4 is a power of 2 and m≥2. By a detailed analysis of some useful properties about q2-ary cyclotomic cosets modulo n, Hermitian dual-containing conditions for a family of non-narrow-sense antiprimitive BCH codes are presented, which are similar to those of q2-ary primitive BCH codes. Consequently, via Hermitian Construction, a family of new quantum codes can be derived from these dual-containing BCH codes. Some of these new antiprimitive quantum BCH codes are comparable with those derived from primitive BCH codes.

The Chernobyl accident consequences; Consequences de l'accident de Tchernobyl

Energy Technology Data Exchange (ETDEWEB)

NONE

2001-04-01

Five teen years later, Tchernobyl remains the symbol of the greater industrial nuclear accident. To take stock on this accident, this paper proposes a chronology of the events and presents the opinion of many international and national organizations. It provides also web sites references concerning the environmental and sanitary consequences of the Tchernobyl accident, the economic actions and propositions for the nuclear safety improvement in the East Europe. (A.L.B.)

Apply Functional Modelling to Consequence Analysis in Supervision Systems

DEFF Research Database (Denmark)

Zhang, Xinxin; Lind, Morten; Gola, Giulio

2013-01-01

This paper will first present the purpose and goals of applying functional modelling approach to consequence analysis by adopting Multilevel Flow Modelling (MFM). MFM Models describe a complex system in multiple abstraction levels in both means-end dimension and whole-part dimension. It contains...... consequence analysis to practical or online applications in supervision systems. It will also suggest a multiagent solution as the integration architecture for developing tools to facilitate the utilization results of functional consequence analysis. Finally a prototype of the multiagent reasoning system...... causal relations between functions and goals. A rule base system can be developed to trace the causal relations and perform consequence propagations. This paper will illustrate how to use MFM for consequence reasoning by using rule base technology and describe the challenges for integrating functional...

The reality of life safety consequence classification

International Nuclear Information System (INIS)

Hartford, D.N.D.; Assaf, H.; Kerr, I.R.

1999-01-01

Because empirical methods of consequence estimation were not designed for application in risk analysis for dam safety, BC Hydro developed its own method for determining loss of life due to dam failures as part of the development of the risk analysis process. Because loss of life estimation for consequence classification entails the generation of essentially the same information, the method can also be used to determine the consequence category of the dam for life safety considerations, and the model can be extended to third party property damage. The methodology adopted for dealing with life safety differs considerably from the empirical approach by modelling the response of the downstream population to a dam failure flood. The algorithm simulates the response of various groups of populations to the warnings of dam failure and the physical process of fleeing from the areas of potential innundation. Assessing the life safety consequences of dam failure is a first step in estimating dam safety in terms of CDA Guidelines, and empirical methods in use are not suitable for determining loss of life due to dam failures. The process described herein is the only physically based method available for estimating loss of life due to dam failures required by the Dam Safety Guidelines. The model is transparent, logically sound, and has been peer reviewed. The method provides a rational basis for the first step in performing safety assessments of dams in terms of the Guidelines, particularly high consequence dams. 8 refs., 3 figs

The Chernobyl accidents: Causes and Consequences

International Nuclear Information System (INIS)

Chihab-Eddine, A.

1988-01-01

The objective of this communication is to discuss the causes and the consequences of the Chernobyl accident. To facilitate the understanding of the events that led to the accident, the author gave a simplified introduction to the important physics that goes on in a nuclear reactor and he presented a brief description and features of chernobyl reactor. The accident scenario and consequences have been presented. The common contribution factors that led to both Three Mile Island and Chernobyl accidents have been pointed out.(author)

Observational Consequences of an Interacting Multiverse

Science.gov (United States)

Robles-Pérez, Salvador

2017-05-01

The observability of the multiverse is at the very root of its physical significance as a scientific proposal. In this conference we present, within the third quantization formalism, an interacting scheme between the wave functions of different universes and analyze the effects of some particular values of the coupling function. One of the main consequences of the interaction between universes can be the appearance of a pre-inflationary stage in the evolution of the universes that might leave observable consequences in the properties of the CMB.

Acromegaly : irreversible clinical consequences

NARCIS (Netherlands)

Wassenaar, Monica Johanna Elisabeth

2010-01-01

This thesis describes the long-term consequences of growth hormone and insulin-like growth factor I excess in patients cured from acromegaly for a mean duration of 17 years. Regarding the considerable prevalence of diverse morbidity in these patients, during the active phase of the disease but even

Health effects estimation code development for accident consequence analysis

International Nuclear Information System (INIS)

Togawa, O.; Homma, T.

1992-01-01

As part of a computer code system for nuclear reactor accident consequence analysis, two computer codes have been developed for estimating health effects expected to occur following an accident. Health effects models used in the codes are based on the models of NUREG/CR-4214 and are revised for the Japanese population on the basis of the data from the reassessment of the radiation dosimetry and information derived from epidemiological studies on atomic bomb survivors of Hiroshima and Nagasaki. The health effects models include early and continuing effects, late somatic effects and genetic effects. The values of some model parameters are revised for early mortality. The models are modified for predicting late somatic effects such as leukemia and various kinds of cancers. The models for genetic effects are the same as those of NUREG. In order to test the performance of one of these codes, it is applied to the U.S. and Japanese populations. This paper provides descriptions of health effects models used in the two codes and gives comparisons of the mortality risks from each type of cancer for the two populations. (author)

Collagen gel contraction serves to rapidly distinguish epithelial- and mesenchymal-derived cells irrespective of alpha-smooth muscle actin expression

DEFF Research Database (Denmark)

Nielsen, Helga Lind; Gudjonsson, Thorarinn; Villadsen, René

2004-01-01

Mesenchymal-like cells in the stroma of breast cancer may arise as a consequence of plasticity within the epithelial compartment, also referred to as epithelial-mesenchymal transition, or by recruitment of genuine mesenchymal cells from the peritumoral stroma. Cells of both the epithelial...... compartment and the stromal compartment express alpha smooth muscle actin (alpha-sm actin) as part of a myoepithelial or a myofibroblastic differentiation program, respectively. Moreover, because both epithelial- and mesenchymal-derived cells are nontumorigenic, other means of discrimination are warranted....... Here, we describe the contraction of hydrated collagen gels as a rapid functional assay for the distinction between epithelial- and mesenchymal-derived stromal-like cells irrespective of the status of alpha-sm actin expression. Three epithelial-derived cell lines and three genuine mesenchymal...

Towards Investigating Global Warming Impact on Human Health Using Derivatives of Photoplethysmogram Signals

Science.gov (United States)

Elgendi, Mohamed; Norton, Ian; Brearley, Matt; Fletcher, Richard R.; Abbott, Derek; Lovell, Nigel H.; Schuurmans, Dale

2015-01-01

Recent clinical studies show that the contour of the photoplethysmogram (PPG) wave contains valuable information for characterizing cardiovascular activity. However, analyzing the PPG wave contour is difficult; therefore, researchers have applied first or higher order derivatives to emphasize and conveniently quantify subtle changes in the filtered PPG contour. Our hypothesis is that analyzing the whole PPG recording rather than each PPG wave contour or on a beat-by-beat basis can detect heat-stressed subjects and that, consequently, we will be able to investigate the impact of global warming on human health. Here, we explore the most suitable derivative order for heat stress assessment based on the energy and entropy of the whole PPG recording. The results of our study indicate that the use of the entropy of the seventh derivative of the filtered PPG signal shows promising results in detecting heat stress using 20-second recordings, with an overall accuracy of 71.6%. Moreover, the combination of the entropy of the seventh derivative of the filtered PPG signal with the root mean square of successive differences, or RMSSD (a traditional heart rate variability index of heat stress), improved the detection of heat stress to 88.9% accuracy. PMID:26473907

Towards Investigating Global Warming Impact on Human Health Using Derivatives of Photoplethysmogram Signals

Directory of Open Access Journals (Sweden)

Mohamed Elgendi

2015-10-01

Full Text Available Recent clinical studies show that the contour of the photoplethysmogram (PPG wave contains valuable information for characterizing cardiovascular activity. However, analyzing the PPG wave contour is difficult; therefore, researchers have applied first or higher order derivatives to emphasize and conveniently quantify subtle changes in the filtered PPG contour. Our hypothesis is that analyzing the whole PPG recording rather than each PPG wave contour or on a beat-by-beat basis can detect heat-stressed subjects and that, consequently, we will be able to investigate the impact of global warming on human health. Here, we explore the most suitable derivative order for heat stress assessment based on the energy and entropy of the whole PPG recording. The results of our study indicate that the use of the entropy of the seventh derivative of the filtered PPG signal shows promising results in detecting heat stress using 20-second recordings, with an overall accuracy of 71.6%. Moreover, the combination of the entropy of the seventh derivative of the filtered PPG signal with the root mean square of successive differences, or RMSSD (a traditional heart rate variability index of heat stress, improved the detection of heat stress to 88.9% accuracy.

Towards Investigating Global Warming Impact on Human Health Using Derivatives of Photoplethysmogram Signals.

Science.gov (United States)

Elgendi, Mohamed; Norton, Ian; Brearley, Matt; Fletcher, Richard R; Abbott, Derek; Lovell, Nigel H; Schuurmans, Dale

2015-10-14

Recent clinical studies show that the contour of the photoplethysmogram (PPG) wave contains valuable information for characterizing cardiovascular activity. However, analyzing the PPG wave contour is difficult; therefore, researchers have applied first or higher order derivatives to emphasize and conveniently quantify subtle changes in the filtered PPG contour. Our hypothesis is that analyzing the whole PPG recording rather than each PPG wave contour or on a beat-by-beat basis can detect heat-stressed subjects and that, consequently, we will be able to investigate the impact of global warming on human health. Here, we explore the most suitable derivative order for heat stress assessment based on the energy and entropy of the whole PPG recording. The results of our study indicate that the use Int. J. Environ. Res. Public Health 2015, 7 12777 of the entropy of the seventh derivative of the filtered PPG signal shows promising results in detecting heat stress using 20-second recordings, with an overall accuracy of 71.6%. Moreover, the combination of the entropy of the seventh derivative of the filtered PPG signal with the root mean square of successive differences, or RMSSD (a traditional heart rate variability index of heat stress), improved the detection of heat stress to 88.9% accuracy.

Is multiset consequence trivial?

Czech Academy of Sciences Publication Activity Database

Cintula, Petr; Paoli, F.

First Online: 08 September 2016 (2018) ISSN 0039-7857 R&D Projects: GA ČR GA13-14654S EU Projects: European Commission(XE) 689176 - SYSMICS Institutional support: RVO:67985807 Keywords : contraction-free logics * multiset consequence * substructural logics * multiple conclusions Subject RIV: BA - General Mathematics Impact factor: 0.855, year: 2016

Assessing the consequences of unrealistic optimism: Challenges and recommendations.

Science.gov (United States)

Shepperd, James A; Pogge, Gabrielle; Howell, Jennifer L

2017-04-01

Of the hundreds of studies published on unrealistic optimism (i.e., expecting a better personal future than is reasonably likely), most have focused on demonstrating the phenomenon, examining boundary conditions, or documenting causes. Few studies have examined the consequences of unrealistic optimism. In this article, we provide an overview of the measurement of unrealistic optimism, review possible consequences, and identify numerous challenges confronting investigators attempting to understand the consequences. Assessing the consequences of unrealistic optimism is tricky, and ultimately probably impossible when researchers assess unrealistic optimism at the group level (which reveals if a group of people is displaying unrealistic optimism on average) rather than the individual level (which reveals whether a specific individual displays unrealistic optimism). We offer recommendations to researchers who wish to examine the consequences of unrealistic optimism. Copyright © 2016 Elsevier Inc. All rights reserved.

Observational Consequences of an Interacting Multiverse

Directory of Open Access Journals (Sweden)

Salvador J. Robles-Pérez

2017-05-01

Full Text Available The observability of the multiverse is at the very root of its physical significance as a scientific proposal. In this conference we present, within the third quantization formalism, an interacting scheme between the wave functions of different universes and analyze the effects of some particular values of the coupling function. One of the main consequences of the interaction between universes can be the appearance of a pre-inflationary stage in the evolution of the universes that might leave observable consequences in the properties of the CMB.

Community beliefs about childhood obesity: its causes, consequences and potential solutions.

Science.gov (United States)

Covic, Tanya; Roufeil, Louise; Dziurawiec, Suzanne

2007-06-01

The objective of this study was to explore community beliefs about the causes, consequences and potential solutions of childhood obesity. A convenience sample of 434 adults (41.2 +/- 13.3 years; 61% parents) in New South Wales, Australia, was surveyed using a newly developed childhood obesity scale. Five causal (emotional eating; eating habits and food knowledge; environmental dysfunction; abundance of contemporary lifestyle; cost of contemporary lifestyle), four consequences (known consequences of obesity; behavioural consequences; social consequences; less-known physical consequences) and three potential solutions factors (parental actions; professional assistance; limiting behaviours) were identified. Parents did not differ from non-parents across the 12 factors nor were there any differences based on the level of education. There were, however, gender differences across two causal factors (emotional eating and abundance of contemporary lifestyle) and two consequences factors (behavioural consequences and social consequences), with females endorsing all four factors more strongly than males. The results of this study suggest that this sample was aware of the complex nature of childhood obesity in terms of its causes, consequences and a range of potential solutions, but they endorsed more family rather than community-based interventions.

Parasite-Derived Proteins for the Treatment of Allergies and Autoimmune Diseases

Directory of Open Access Journals (Sweden)

Zhenyu Wu

2017-11-01

Full Text Available The morbidity associated with atopic diseases and immune dysregulation disorders such as asthma, food allergies, multiple sclerosis, atopic dermatitis, type 1 diabetes mellitus, and inflammatory bowel disease has been increasing all around the world over the past few decades. Although the roles of non-biological environmental factors and genetic factors in the etiopathology have been particularly emphasized, they do not fully explain the increase; for example, genetic factors in a population change very gradually. Epidemiological investigation has revealed that the increase also parallels a decrease in infectious diseases, especially parasitic infections. Thus, the reduced prevalence of parasitic infections may be another important reason for immune dysregulation. Parasites have co-evolved with the human immune system for a long time. Some parasite-derived immune-evasion molecules have been verified to reduce the incidence and harmfulness of atopic diseases in humans by modulating the immune response. More importantly, some parasite-derived products have been shown to inhibit the progression of inflammatory diseases and consequently alleviate their symptoms. Thus, parasites, and especially their products, may have potential applications in the treatment of autoimmune diseases. In this review, the potential of parasite-derived products and their analogs for use in the treatment of atopic diseases and immune dysregulation is summarized.

Hemin-Graphene Derivatives with Increased Peroxidase Activities Restrain Protein Tyrosine Nitration.

Science.gov (United States)

Xu, Huan; Yang, Zhen; Li, Hailing; Gao, Zhonghong

2017-12-14

Protein tyrosine nitration is implicated in the occurrence and progression of pathological conditions involving free radical reactions. It is well recognized that hemin can catalyze protein tyrosine nitration in the presence of nitrite and hydrogen peroxide. Generally, the catalytic efficiency is positively correlated to its peroxidase activity. In this study, however, it is found that the efficiency of hemin in catalyzing protein tyrosine nitration is largely suppressed after functionalization with graphene derivatives, even though its peroxidase-like activity is more than quadrupled. Further studies show that the oxidation of tyrosine is still observed for these composites; dityrosine formation, however, is greatly inhibited. Furthermore, these composites also exhibit strong effects on the oxidation of nitrite into nitrate. Therefore, we propose a mechanism in which hemin-graphene derivatives facilitate the oxidation of tyrosine and nitrite to produce tyrosyl radicals and nitrogen dioxide radicals in the presence of hydrogen peroxide, but graphene interlayers serve as barriers that hinder radical-radical coupling reactions; consequently, protein tyrosine nitration is restrained. This property of hemin-graphene derivatives, by which they catalyze substrate oxidation but suppress radical-radical coupling reactions, shows their great potential in selective oxidation procedures for byproduct removal. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Consequence-driven cyber-informed engineering (CCE)

Energy Technology Data Exchange (ETDEWEB)

Freeman, Sarah G. [Idaho National Lab. (INL), Idaho Falls, ID (United States); St Michel, Curtis [Idaho National Lab. (INL), Idaho Falls, ID (United States); Smith, Robert [Idaho National Lab. (INL), Idaho Falls, ID (United States); Assante, Michael [Idaho National Lab. (INL), Idaho Falls, ID (United States)

2016-10-18

The Idaho National Lab (INL) is leading a high-impact, national security-level initiative to reprioritize the way the nation looks at high-consequence risk within the industrial control systems (ICS) environment of the country’s most critical infrastructure and other national assets. The Consequence-driven Cyber-informed Engineering (CCE) effort provides both private and public organizations with the steps required to examine their own environments for high-impact events/risks; identify implementation of key devices and components that facilitate that risk; illuminate specific, plausible cyber attack paths to manipulate these devices; and develop concrete mitigations, protections, and tripwires to address the high-consequence risk. The ultimate goal of the CCE effort is to help organizations take the steps necessary to thwart cyber attacks from even top-tier, highly resourced adversaries that would result in a catastrophic physical effect. CCE participants are encouraged to work collaboratively with each other and with key U.S. Government (USG) contributors to establish a coalition, maximizing the positive effect of lessons-learned and further contributing to the protection of critical infrastructure and other national assets.

Somite-Derived Retinoic Acid Regulates Zebrafish Hematopoietic Stem Cell Formation.

Directory of Open Access Journals (Sweden)

Laura M Pillay

Full Text Available Hematopoietic stem cells (HSCs are multipotent progenitors that generate all vertebrate adult blood lineages. Recent analyses have highlighted the importance of somite-derived signaling factors in regulating HSC specification and emergence from dorsal aorta hemogenic endothelium. However, these factors remain largely uncharacterized. We provide evidence that the vitamin A derivative retinoic acid (RA functions as an essential regulator of zebrafish HSC formation. Temporal analyses indicate that RA is required for HSC gene expression prior to dorsal aorta formation, at a time when the predominant RA synthesis enzyme, aldh1a2, is strongly expressed within the paraxial mesoderm and somites. Previous research implicated the Cxcl12 chemokine and Notch signaling pathways in HSC formation. Consequently, to understand how RA regulates HSC gene expression, we surveyed the expression of components of these pathways in RA-depleted zebrafish embryos. During somitogenesis, RA-depleted embryos exhibit altered expression of jam1a and jam2a, which potentiate Notch signaling within nascent endothelial cells. RA-depleted embryos also exhibit a severe reduction in the expression of cxcr4a, the predominant Cxcl12b receptor. Furthermore, pharmacological inhibitors of RA synthesis and Cxcr4 signaling act in concert to reduce HSC formation. Our analyses demonstrate that somite-derived RA functions to regulate components of the Notch and Cxcl12 chemokine signaling pathways during HSC formation.

Consequences of dark matter-dark energy interaction on cosmological parameters derived from type Ia supernova data

International Nuclear Information System (INIS)

Amendola, Luca; Campos, Gabriela Camargo; Rosenfeld, Rogerio

2007-01-01

Models where the dark matter component of the Universe interacts with the dark energy field have been proposed as a solution to the cosmic coincidence problem, since in the attractor regime both dark energy and dark matter scale in the same way. In these models the mass of the cold dark matter particles is a function of the dark energy field responsible for the present acceleration of the Universe, and different scenarios can be parametrized by how the mass of the cold dark matter particles evolves with time. In this article we study the impact of a constant coupling δ between dark energy and dark matter on the determination of a redshift dependent dark energy equation of state w DE (z) and on the dark matter density today from SNIa data. We derive an analytical expression for the luminosity distance in this case. In particular, we show that the presence of such a coupling increases the tension between the cosmic microwave background data from the analysis of the shift parameter in models with constant w DE and SNIa data for realistic values of the present dark matter density fraction. Thus, an independent measurement of the present dark matter density can place constraints on models with interacting dark energy

Timing is crucial for consequences of migratory connectivity

NARCIS (Netherlands)

Bauer, Silke; Lisovski, Simeon; Hahn, Steffen

Migratory connectivity can have important consequences for individuals, populations and communities. We argue that most consequences not only depend on which sites are used but importantly also on when these are used and suggest that the timing of migration is characterised by synchrony, phenology,

Child sexual abuse: consequences and implications.

Science.gov (United States)

Hornor, Gail

2010-01-01

Sexual abuse is a problem of epidemic proportions in the United States. Given the sheer numbers of sexually abused children, it is vital for pediatric nurse practitioners to understand both short-term and long-term consequences of sexual abuse. Understanding consequences of sexual abuse can assist the pediatric nurse practitioner in anticipating the physical and mental health needs of patients and also may assist in the identification of sexual abuse victims. Sexual abuse typically does not occur in isolation. Implications for practice will be discussed. Copyright © 2010 National Association of Pediatric Nurse Practitioners. Published by Mosby, Inc. All rights reserved.

Panel on atmospheric and climatic consequences

International Nuclear Information System (INIS)

Anon.

1984-01-01

This article reviews some of the important details and undergirding of the presentations on the atmospheric, climatic and biological consequences of nuclear war. The discussion focuses on two questions that have been raised: whether the scenerios that have been presented are a credible basis for analysis of the consequences of possible nuclear wars, given the sizes of the existing arsenals and the available knowledge about how these arsenals might be used; and, whether the various numbers that were given for radiation doses from fallout are in fact internally consistent and compatible with those calculated by other analysts

Exploring Undergraduate Engagement With The Consequences of Climate Change

Science.gov (United States)

Young, N.; Danielson, R.; Lombardi, D.

2013-12-01

Engendering conceptual change from naive to scientifically sophisticated beliefs is a difficult task. One factor that fosters conceptual change is greater engagement with a topic. Yet if one asks about a topic in the wrong way, one may fail to find engagement where it exists or assume it exists where it does not. Climate change is an immense topic with consequences across many domains and people may be more concerned with specific consequences than with the topic generally. Therefore, it may be helpful to disambiguate the various risks to see which consequences people find especially engaging and which they do not. We asked 188 undergraduate students at a large university in California to rate twenty-five potential consequences of climate change on several questions. The questions were drawn from constructs that lead to greater engagement with a topic according to the Cognitive Reconstruction of Knowledge Model (Dole & Sinatra, 1998). Scores were then combined to create engagement scores. We found that two potential consequences of climate change were rated as more engaging than climate change generally: air pollution and increases in the price of food. Many consequences were rated as less engaging, including floods, stronger hurricanes, and melting permafrost. This implies that some consequences that scientists consider potentially worthy of concern are nonetheless not considered engaging by many. We also asked participants several open-ended questions about their perceptions of climate change and what consequences they especially cared about. Results were broadly similar but demonstrated many misconceptions about the mechanics and consequences of climate change. Several participants expressed concerns about increases in earthquakes, changes to the ozone layer, and dangerous changes to the density of the atmosphere. We asked participants about the relationship between the terms climate change and global warming. There was considerable disagreement on how these two

Consequence and Resilience Modeling for Chemical Supply Chains

Science.gov (United States)

Stamber, Kevin L.; Vugrin, Eric D.; Ehlen, Mark A.; Sun, Amy C.; Warren, Drake E.; Welk, Margaret E.

2011-01-01

The U.S. chemical sector produces more than 70,000 chemicals that are essential material inputs to critical infrastructure systems, such as the energy, public health, and food and agriculture sectors. Disruptions to the chemical sector can potentially cascade to other dependent sectors, resulting in serious national consequences. To address this concern, the U.S. Department of Homeland Security (DHS) tasked Sandia National Laboratories to develop a predictive consequence modeling and simulation capability for global chemical supply chains. This paper describes that capability , which includes a dynamic supply chain simulation platform called N_ABLE(tm). The paper also presents results from a case study that simulates the consequences of a Gulf Coast hurricane on selected segments of the U.S. chemical sector. The case study identified consequences that include impacted chemical facilities, cascading impacts to other parts of the chemical sector. and estimates of the lengths of chemical shortages and recovery . Overall. these simulation results can DHS prepare for and respond to actual disruptions.

49 CFR 195.452 - Pipeline integrity management in high consequence areas.

Science.gov (United States)

2010-10-01

... 49 Transportation 3 2010-10-01 2010-10-01 false Pipeline integrity management in high consequence... Management § 195.452 Pipeline integrity management in high consequence areas. (a) Which pipelines are covered... that could affect a high consequence area, including any pipeline located in a high consequence area...

The consequences of tourism for sustainable water use on a tropical island: Zanzibar, Tanzania.

Science.gov (United States)

Gössling, S

2001-02-01

Many developing countries in the tropics have focused on tourism to generate additional income sources and to diversity the economy. Coastlines in particular have been on the forefront of tourist infrastructure development. Here, the presence of a large number of tourists has often had negative consequences for the sustainable use of the available resources, which in turn has had an effect on the integrity of the ecosystems. In this paper, the situation is described for the use of freshwater resources on the east coast of Zanzibar, Tanzania. This region is water poor, relying on freshwater derived from seasonal rains and stored in less efficient aquifers, which consist of freshwater lenses floating on the underlying seawater. Tourism in the area has grown rapidly in recent years and is expected to further increase in the future. This development is expected to put additional pressure on the freshwater resources of the east coast, which show already signs of over-use. The consequences of overexploitation can include the lowering of the groundwater table, land subsidence, deteriorating groundwater quality, and saltwater intrusion. These, in turn, determine the living conditions in coastal areas and the effects will be felt both by the local populations and the tourist industry. An investigation is made into the causes and consequences of water abstraction by the tourist industry. The results show that present levels of withdrawal are not sustainable, and parts of the local populations are already experiencing water deficits on a daily basis. In the future, if the expected increase in tourist numbers occurs, the pressure on the aquifers will correspondingly increase. The results could be that the tourism in the area becomes unsustainable, which could have an adverse effect on the national economy and also on the local population and environment. Therefore, a precautionary water-management approach is suggested.

The genetic consequences of exposure

International Nuclear Information System (INIS)

Izhewskij, P.W.

1996-01-01

The results of the study of genetic consequences of external gamma-irradiation of man and animals to 1 Sv are given. The investigation was performed in 3 groups under different conditions of exposure of the population: (i) among the people of Russia and Belorussia exposed due to the Chernobyl accident, (ii) among the people living on the Tetscha river basing in the South Urals; (iii) among the occupational contingent of 'Mayak' and the members of their families; The experimental estimation of genetic consequences was made on the offsprings of the white male rats. The male rats were irradiated daily for 10-15 days with external gamma- radiation of different dose power. The range of the doses received by the animals was approximated to the conditions of the exposure of man to the interval from 4 to 79 cSv for a year. (author)

Choice & Consequence

DEFF Research Database (Denmark)

Khan, Azam

to support hypothesis generation, hypothesis testing, and decision making. In addition to sensors in buildings, infrastructure, or the environment, we also propose the instrumentation of user interfaces to help measure performance in decision making applications. We show the benefits of applying principles...... between cause and effect in complex systems complicates decision making. To address this issue, we examine the central role that data-driven decision making could play in critical domains such as sustainability or medical treatment. We developed systems for exploratory data analysis and data visualization...... of data analysis and instructional interface design, to both simulation systems and decision support interfaces. We hope that projects such as these will help people to understand the link between their choices and the consequences of their decisions....

Evaluation of consequences and risks in Slovenia

International Nuclear Information System (INIS)

Susnik, J.

1996-01-01

The paper describes the evaluation of nuclear power plant accident consequences and risks using probabilistic safety codes during the last 12 years at the J. Stefan Institute. They cover classic individual and population risk studies due to assumed potential severe accident scenarios, prediction and estimation of Chernobyl accident consequences, the optimization of emergency countermeasures at the Krsko site, where the 632 MWe Westinghouse PWR NPP went into commercial operation on January 1983, and the ranking of population risk within the public debate in connection with the civil initiative to close the NPP Krsko. We report on the initial use of the CRAC2 code in 1984 and later, when it was first applied for the study of population risk in the area of the second planned Slovenian-Croatian NPP for the Prevlaka site. The study was completed a few weeks before the Chernobyl accident in April 1986. Risk evaluation was also included in the analysis of nuclear safety at the NPP Krsko during the war for Slovenia's independence in 1991. We report on the (CRAC2) analyses of the Chernobyl accident: on initial estimation of the maximal potentially expected consequences in Slovenia, on the effect of the radioactive cloud rise on the consequences relatively close to the NPP; on the further research after the detailed information on the radioactivity release and on the air masses movement were published; then the cloud activity which moved towards Slovenia was assessed and the expected consequences along its path were calculated. As the calculated integral individual exposure to the I 131 inhalation and the ground Cs 137 contamination matched with the measurements in Ljubljana and with the UNSCEAR 1988 data, our reliance on the CRAC2 code and on its ancestors is high. We report on the analyses, performed by the CRAC2 code and since 1993 also by the PC COSYMA code, related to the countermeasure effects. The consequences studied were extended to late health effects. We analyzed

Consequence of potential accidents in heavy water plants

International Nuclear Information System (INIS)

Croitoru, C.; Lazar, R.E.; Preda, I.A.; Dumitrescu, M.

1998-01-01

Heavy water plants realize the primary isotopic concentrations of water using H 2 O-H 2 S chemical exchange and they are chemical plants. As these plants are handling and spreading large quantities of hydrogen sulphide (high toxic, corrosive, flammable and explosive as) maintained in the process at relative high temperatures and pressures, it is required an assessing of risks associated with the potential accidents. The H 2 S released in atmosphere as a result of an accident will have negative consequences to property, population and environment. This paper presents a model of consequences quantitative assessment and its outcome for the most dangerous accident in heavy water plants. Several states of the art risk based methods were modified and linked together to form a proper model for this analyse. Five basic steps to identify the risks involved in operating the plants are followed: hazard identification, accident sequence development, H 2 S emissions calculus, dispersion analyses and consequences determination. A brief description of each step and some information of analysis results are provided. The accident proportions, the atmospheric conditions and the population density in the respective area were accounted for consequences calculus. The specific results of the consequences analysis allow to develop the plant's operating safety requirements so that the risk remain at an acceptable level. (authors)

Assuring quality in high-consequence engineering

Energy Technology Data Exchange (ETDEWEB)

Hoover, Marcey L.; Kolb, Rachel R.

2014-03-01

In high-consequence engineering organizations, such as Sandia, quality assurance may be heavily dependent on staff competency. Competency-dependent quality assurance models are at risk when the environment changes, as it has with increasing attrition rates, budget and schedule cuts, and competing program priorities. Risks in Sandia's competency-dependent culture can be mitigated through changes to hiring, training, and customer engagement approaches to manage people, partners, and products. Sandia's technical quality engineering organization has been able to mitigate corporate-level risks by driving changes that benefit all departments, and in doing so has assured Sandia's commitment to excellence in high-consequence engineering and national service.

Complete abandonment of nuclear power and aggregate consequences

International Nuclear Information System (INIS)

Heilemann, U.; Weiss, T.

1986-01-01

The aggregate social and economic consequences of a complete abandonment of nuclear power very often are pushed to the background in discussions about the MCA. But backing out of nuclear energy will not be achieved or left without costs. The authors present an analysis of the short-term aggregate consequences. (orig./UA) [de

Chernobylsk accident (Causes and Consequences)- Part 2

International Nuclear Information System (INIS)

Esteves, D.

1986-09-01

The causes and consequences of the nuclear accident at Chernobylsk-4 reactor are shortly described. The informations were provided by Russian during the specialist meeting, carried out at seat of IAEA. The Russian nuclear panorama; the site, nuclear power plant characteristics and sequence of events; the immediate measurements after accident; monitoring/radioactive releases; environmental contamination and ecological consequences; measurements of emergency; recommendations to increase the nuclear safety; and recommendations of work groups, are presented. (M.C.K.) [pt

Low-Incidence, High-Consequence Pathogens

Centers for Disease Control (CDC) Podcasts

2014-02-21

Dr. Stephan Monroe, a deputy director at CDC, discusses the impact of low-incidence, high-consequence pathogens globally.  Created: 2/21/2014 by National Center for Emerging and Zoonotic Infectious Diseases (NCEZID).   Date Released: 2/26/2014.

Synthesis and solar-cell applications of novel furanyl-substituted anthracene derivatives

Science.gov (United States)

Kivrak, Arif; Er, Ömer Faruk; Kivrak, Hilal; Topal, Yasemin; Kuş, Mahmut; Çamlısoy, Yesim

2017-11-01

At present, novel furanyl-substituted anthracene derivatives; namely 9,10-di(furan-2-yl)anthracene (DFA), 5,5‧-(anthracene-9,10-diyl)bis(furan-2-carbaldehyde) (DAFA) and 2,2‧-((5,5‧-(anthracene-9,10-diyl)bis(furan-5,2-diyl))bis(methanylylidene))dimalononitrile (DCNFA) were designed and synthesized successfully by employing Stille Cross-Coupling, Vilsmeier-Haack and Knoevenagel condensation reactions, respectively. This methodology provides a practical new route for the synthesis of furanyl-substituted anthracene derivatives bearing strong electron-withdrawing groups. The electrochemical and electro-optical properties of these novel furanyl-substituted anthracene derivatives were also examined with strong acceptor-π-donor-π-acceptor interactions. Furthermore, Highest occupied molecular orbital (HOMO), Lowest Unoccupied molecular orbital (LUMO), and band gap (Eg) values were investigated by using spectroscopic methods. Electrochemical and electro-optical properties were calculated and compared to DFA, DAFA and DCNFA. Eg was found as 2.85, 2.71, and 2.33 eV, respectively. Consequently, Organic Solar Cells (OSC) were fabricated to investigate their solar cell performances. The strong electron withdrawing groups did not increase the solar cell performance of furanyl-anthracenes. Surprisingly, DFA was found to exhibit the best OSCs performance (Efficiency = 3.36). As a result, one could note that these novel furanyl-substituted anthracene derivatives are good candidate for the applications of the OSCs. Our results might help in the development of new materials with important electrochemical functions by giving the advantage of designing and further derivatization of new generation small organic molecules for photovoltaic device applications.

Nonmonotonic Skeptical Consequence Relation in Constrained Default Logic

Directory of Open Access Journals (Sweden)

Mihaiela Lupea

2010-12-01

Full Text Available This paper presents a study of the nonmonotonic consequence relation which models the skeptical reasoning formalised by constrained default logic. The nonmonotonic skeptical consequence relation is defined using the sequent calculus axiomatic system. We study the formal properties desirable for a good nonmonotonic relation: supraclassicality, cut, cautious monotony, cumulativity, absorption, distribution. 

Covariance matrices for nuclear cross sections derived from nuclear model calculations

International Nuclear Information System (INIS)

Smith, D. L.

2005-01-01

The growing need for covariance information to accompany the evaluated cross section data libraries utilized in contemporary nuclear applications is spurring the development of new methods to provide this information. Many of the current general purpose libraries of evaluated nuclear data used in applications are derived either almost entirely from nuclear model calculations or from nuclear model calculations benchmarked by available experimental data. Consequently, a consistent method for generating covariance information under these circumstances is required. This report discusses a new approach to producing covariance matrices for cross sections calculated using nuclear models. The present method involves establishing uncertainty information for the underlying parameters of nuclear models used in the calculations and then propagating these uncertainties through to the derived cross sections and related nuclear quantities by means of a Monte Carlo technique rather than the more conventional matrix error propagation approach used in some alternative methods. The formalism to be used in such analyses is discussed in this report along with various issues and caveats that need to be considered in order to proceed with a practical implementation of the methodology

Priority pollutant analysis of MHD-derived combustion products

Science.gov (United States)

Parks, Katherine D.

An important factor in developing Magnetohydrodynamics (MHD) for commercial applications is environmental impact. Consequently, an effort was initiated to identify and quantify any possible undesirable minute chemical constituents in MHD waste streams, with special emphasis on the priority pollutant species. This paper discusses how priority pollutant analyses were used to accomplish the following goals at the University of Tennessee Space Institute (UTSI): comparison of the composition of solid combustion products collected from various locations along a prototypical MHD flow train during the firing of Illinois No. 6 and Montana Rosebud coals; comparison of solid waste products generated from MHD and conventional power plant technologies; and identification of a suitable disposal option for various MHD derived combustion products. Results from our ongoing research plans for gas phase sampling and analysis of priority pollutant volatiles, semi-volatiles, and metals are discussed.

Toward a Systemic Notion of Information: Practical Consequences

Directory of Open Access Journals (Sweden)

Nagib Callaos

2002-01-01

Full Text Available Our main purpose in this paper is to start a process of a systemic definition of the notion of information and to provide some initial practical consequences of it. We will try to do that providing: 1 a conceptual definition, following Ackoff's (1962 description and method of such a kind of definition, and 2 following Peirce's (1931-5,1958 conception of "meaning", where the practical consequences should be included. To our knowledge, no attempt has been done up to the present neither to find a Peircean meaning to the notion of information, nor to start a process of describing a systemic notion of information. Consequently, we will try to integrate the different definitions made on information. But to integrate we should first differentiate what is to be integrated. Thus, we will typify information conceptions in subjective and objective, providing brief description and analysis of each type, integrating them in the context of a systemic notion of information, and drawing the respective pragmatic consequences, as required by Peirce, for any meaning description, and by a pragmatic-teleological systemic epistemology (Churchmann, 1971

The associations among prior drinking consequences, subjective evaluations, and subsequent alcohol outcomes.

Science.gov (United States)

Zaso, Michelle J; Park, Aesoon; Kim, Jueun; Gellis, Les A; Kwon, Hoin; Maisto, Stephen A

2016-05-01

Although the many positive and negative psychosocial consequences of alcohol use are well documented, evidence of the association between prior drinking consequences and subsequent alcohol-related outcomes is mixed. Social learning theory highlights that cognitive appraisals of prior drinking consequences play a crucial intermediate role in the relation of prior drinking consequences with subsequent alcohol-related outcomes. This prospective study was designed to test the mediating effects of subjective evaluations (i.e., perceived valence and controllability) in the association of prior drinking consequences with change in binge drinking and drinking consequences over time. Participants were 171 college students (69% female, 74% White, M age = 18.95 years, SD = 1.35) who completed 2 online surveys, with an average interval of 68 days (SD = 10.22) between assessments. Path analyses of the data did not support mediational effects of perceived valence or controllability of prior drinking consequences on subsequent alcohol-related outcomes. Specifically, greater frequency of negative consequences was associated with lower perceived valence and controllability, and greater frequency of positive consequences was associated with lower perceived controllability of the experienced consequences. However, perceptions of valence and controllability were not in turn associated with subsequent binge drinking and drinking consequences. Instead, greater frequency of positive consequences was directly associated with greater subsequent frequency of binge drinking. Findings highlight the importance of prior positive consequences in the escalation of binge drinking over a short period of time, although this relation may not be accounted for by perceptions of valence and controllability of the prior drinking consequences. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

Diagnostic Invasiveness and Psychosocial Consequences of False-Positive Mammography

DEFF Research Database (Denmark)

Heleno, Bruno M.; Siersma, Volkert Dirk; Brodersen, John

2015-01-01

PURPOSE: We undertook a study to assess whether women with false-positivemammography have worse psychosocial consequences if managed with aworkup that involves a biopsy (invasive group) than if managed with only additional imaging (noninvasive group). METHODS: We performed subgroup analysis...... of a cohort study of 454 womenwith abnormal screening mammography and 908 matched control women withnormal results. Using a condition-specific questionnaire (Consequences of Screening in Breast Cancer), we assessed 12 psychosocial consequences at 5 time points (0, 1, 6, 18, and 36 months after final diagnosis......) and compared the 2 groups of women with false-positives (invasive and noninvasive management groups). RESULTS: Among the 252 women with false-positive mammography eligible forthis study, psychosocial consequences were similar for those managed invasivelyand those managed noninvasively during the 36 months...

A Classical Based Derivation of Time Dilation Providing First Order Accuracy to Schwarzschild's Solution of Einstein's Field Equations

Science.gov (United States)

Austin, Rickey W.

In Einstein's theory of Special Relativity (SR), one method to derive relativistic kinetic energy is via applying the classical work-energy theorem to relativistic momentum. This approach starts with a classical based work-energy theorem and applies SR's momentum to the derivation. One outcome of this derivation is relativistic kinetic energy. From this derivation, it is rather straight forward to form a kinetic energy based time dilation function. In the derivation of General Relativity a common approach is to bypass classical laws as a starting point. Instead a rigorous development of differential geometry and Riemannian space is constructed, from which classical based laws are derived. This is in contrast to SR's approach of starting with classical laws and applying the consequences of the universal speed of light by all observers. A possible method to derive time dilation due to Newtonian gravitational potential energy (NGPE) is to apply SR's approach to deriving relativistic kinetic energy. It will be shown this method gives a first order accuracy compared to Schwarzschild's metric. The SR's kinetic energy and the newly derived NGPE derivation are combined to form a Riemannian metric based on these two energies. A geodesic is derived and calculations compared to Schwarzschild's geodesic for an orbiting test mass about a central, non-rotating, non-charged massive body. The new metric results in high accuracy calculations when compared to Einsteins General Relativity's prediction. The new method provides a candidate approach for starting with classical laws and deriving General Relativity effects. This approach mimics SR's method of starting with classical mechanics when deriving relativistic equations. As a compliment to introducing General Relativity, it provides a plausible scaffolding method from classical physics when teaching introductory General Relativity. A straight forward path from classical laws to General Relativity will be derived. This derivation

[Caregiving consequences in mental disorders--definitions and instruments of assessment].

Science.gov (United States)

Ciałkowska-Kuźmińska, Magdalena; Kiejna, Andrzej

2010-01-01

Severe mental illnesses have far-reaching consequences for both patients and their relatives. This paper reviews literature on the measures of caregiving consequences. Authors provide a condensed knowledge and research results in the area of caregiving consequences, especially both subjective and objective caregivers' burden. The consequences of care apply to carers' social and leisure activities, financial status, health condition. The burden of care has three fundamental causes: the reorganisation of mental health services, a social isolation of patients and their families and the lack of systemic support for caregivers. The problem of caregiving consequences has been investigated in several studies. In order to identify factors, which have impact on caregiver distress, a variety instruments have been developed. This paper focuses on questionnaires useful for the systematic assessment of both objective and subjective burden: Involvement Evaluation Questionnaire (IEQ), Perceived Family Burden Scale (PFBS), Zarit Caregiver Burden Scale (ZCBS), Experience of Caregiving Inventory (ECI), Family Problems Questionnaire (FPQ). The mentioned instruments proved to be a reliable instrument for measuring caregiver consequences in mental healthcare.

Economic consequences of biological variation

DEFF Research Database (Denmark)

Otto, Lars

2005-01-01

We present an economic decision support model, based on a Bayesian network, for Mycoplasma infection in slaughter swine production. The model describes the various risk factors for Mycoplasma infection and their interactions. This leads to a stochastic determination of the consequences of product...

The macroeconomic consequences of downsizing

NARCIS (Netherlands)

de Groot, H.L.F.; van Schaik, A.B.T.M.

2002-01-01

The recession in the 1980s followed by the worldwide decrease in transportation and communication costs has triggered a process of downsizing. The macroeconomic consequences of this process are only weakly understood. The model developed in this paper associates downsizing with trade between

Clinical Impact of the Immunome in Lymphoid Malignancies: The Role of Myeloid-Derived Suppressor Cells

Science.gov (United States)

Vetro, Calogero; Romano, Alessandra; Ancora, Flavia; Coppolino, Francesco; Brundo, Maria V.; Raccuia, Salvatore A.; Puglisi, Fabrizio; Tibullo, Daniele; La Cava, Piera; Giallongo, Cesarina; Parrinello, Nunziatina L.

2015-01-01

The better definition of the mutual sustainment between neoplastic cells and immune system has been translated from the bench to the bedside acquiring value as prognostic factor. Additionally, it represents a promising tool for improving therapeutic strategies. In this context, myeloid-derived suppressor cells (MDSCs) have gained a central role in tumor developing with consequent therapeutic implications. In this review, we will focus on the biological and clinical impact of the study of MDSCs in the settings of lymphoid malignancies. PMID:26052505

Gender matters: the relationship between social anxiety and alcohol-related consequences.

Science.gov (United States)

Schry, Amie R; Norberg, Melissa M; Maddox, Brenna B; White, Susan W

2014-01-01

Identification of risk factors for alcohol-related consequences is an important public health concern. Both gender and social anxiety have been associated with alcohol-related consequences broadly, but it is unknown whether these variables are differentially related to specific types of alcohol-related consequences for American college students. In the present study, 573 undergraduate students (M(age) = 19.86 years, SD = 1.40; range 18 to 25; 68.9% female) completed an on-line assessment of social anxiety, alcohol use, and four types of alcohol-related consequences (personal, social, physical, and role). Poisson regressions were run to examine social anxiety, gender, and the interaction between social anxiety and gender as predictors of each type of alcohol-related consequences. After controlling for alcohol use, social anxiety was positively associated with all four types of consequences, and females endorsed higher rates of physical, personal, and role consequences. The interaction between social anxiety and gender was statistically significant only for physical consequences, with social anxiety having a stronger effect for males. These findings, which diverge somewhat from those of a prior study with Australian college students, are discussed in the context of a biopsychosocial model of social anxiety and substance use problems. This study highlights the importance of further investigating cultural differences in the relationships among social anxiety, gender, and alcohol-related consequences.

Consequences assessment for fuel channel failure with consequential moderator drain

International Nuclear Information System (INIS)

Wahba, N.N.; Bayoumi, M.H.

2002-01-01

This paper documents the consequences of spontaneous pressure tube/consequential calandria tube rupture followed by the ejection of end fittings (as a result of guillotine failure of pressure tube) leading to the drain of the moderator. The event is postulated to occur in conjunction with an independent failure of Emergency Coolant Injection System (ECIS). The results of the detailed consequence assessments are used to propose a course of action to mitigate the consequences of such an event. A methodology based on a lumped-parameter model was developed to assess the consequences of the postulated event. (author)

CONTROVERSIES IN USING DERIVATIVES IN THE CONTEXT OF THE FINANCIAL CRISIS

Directory of Open Access Journals (Sweden)

ALEXANDRU OLTEANU

2011-04-01

manage risks that derive from its activity and, for this purpose, to take into consideration the use of derivatives. Recent financial collapses have illustrated the consequences generated by the improper application of the basic risk management principles and of the efficient implementation strategies for derivatives.

Immunomodulatory effects of the aromatic geranyl derivative filifolinone tested by the induction of cytokine expression.

Science.gov (United States)

Valenzuela, Beatriz; Imarai, Mónica; Torres, René; Modak, Brenda

2013-12-01

Fish farming crops are constantly exposed to infectious diseases due to intensive production conditions under which microorganisms develop and spread easily, resulting in severe economic losses. The massive use of antibiotics to control these diseases has lead to the accumulation of residues and the development of drug resistance. Consequently, it is urgent to develop new pharmacological tools to stimulate protective immune responses in salmonids to combat infectious diseases. We evaluated the immunostimulant activity of terpenoid derivatives isolated from species of the Heliotropium genus, which had previously shown antiviral activity in salmon. The immunomodulatory effects of the 3 H-spiro [1-benzofuran-2,1'-ciclohexane] derivative called filifolinone, were studied in vitro using the SHK-1 cell line derived from leucocytes of salmon head kidney and in vivo in Atlantic salmon. For the evaluation, we studied the effect of this compound in the expression of various cytokines. The results showed that Filifolinone increases the levels of expression of pro-inflammatory and anti-inflammatory cytokines. This suggests that Filifolinone is a potential alternative immunomodulator for veterinary purposes. Copyright © 2013 Elsevier Ltd. All rights reserved.

Literacy in Somali: Linguistic Consequences.

Science.gov (United States)

Biber, Douglas; Hared, Mohamed

1991-01-01

Linguistic consequences of literacy in Somalia are examined in a review of the literature and through a study of five dimensions of variation among Somali registers and the expansion of linguistic variation in Somali resulting from the introduction of written registers. (36 references) (LB)

Anticipating the Social Consequences of AIDS: A Position Paper.

Science.gov (United States)

Berk, Richard A.; And Others

1981-01-01

Focuses on the social consequences of the AIDS epidemic, arguing that sociologists have an important contribution to make in planning for the long-range social consequences of AIDS. Concludes with three different commentaries on Berk's article. (Author/BSR)

Particle size - An important factor in environmental consequence modeling

International Nuclear Information System (INIS)

Yuan, Y.C.; MacFarlane, D.

1991-01-01

Most available environmental transport and dosimetry codes for radiological consequence analysis are designed primarily for estimating dose and health consequences to specific off-site individuals as well as the population as a whole from nuclear facilities operating under either normal or accident conditions. Models developed for these types of analyses are generally based on assumptions that the receptors are at great distances (several kilometers), and the releases are prolonged and filtered. This allows the use of simplified approaches such as averaged meteorological conditions and the use of a single (small) particle size for atmospheric transport and dosimetry analysis. Source depletion from particle settling, settle-out, and deposition is often ignored. This paper estimates the effects of large particles on the resulting dose consequences from an atmospheric release. The computer program AI-RISK has been developed to perform multiparticle-sized atmospheric transport, dose, and pathway analyses for estimating potential human health consequences from the accidental release of radioactive materials. The program was originally developed to facilitate comprehensive analyses of health consequences, ground contamination, and cleanup associated with possible energetic chemical reactions in high-level radioactive waste (HLW) tanks at a US Department of Energy site

Initiatives and Challenges in Consequence Management after a WMD Attack

Science.gov (United States)

2004-08-01

Challenges in Consequence Management people to seek shelter or other protection when possible, to avoid exposure to weapons of mass destruction effects . The...Potential Effects .........................................9 V. Methods for Managing the Consequences of WMD Use.................14 VI. Toward a...mass destruction (WMD). Consequence management1 is a process to mitigate the effects of the use of weapons of mass destruction, including

Towards accurate structural characterization of metal centres in protein crystals: the structures of Ni and Cu T6 bovine insulin derivatives

DEFF Research Database (Denmark)

Frankær, Christian Grundahl; Mossin, Susanne; Ståhl, Kenny

2014-01-01

Using synchrotron radiation (SR), the crystal structures of T6 bovine insulin complexed with Ni2+ and Cu2+ were solved to 1.50 and 1.45 Å resolution, respectively. The level of detail around the metal centres in these structures was highly limited, and the coordination of water in Cu site II...... of the copper insulin derivative was deteriorated as a consequence of radiation damage. To provide more detail, X-ray absorption spectroscopy (XAS) was used to improve the information level about metal coordination in each derivative. The nickel derivative contains hexacoordinated Ni2+ with trigonal symmetry...... by electron paramagnetic resonance (EPR). The coordination distances were refined from EXAFS with standard deviations within 0.01 Å. The insulin derivative containing Cu2+ is sensitive towards photoreduction when exposed to SR. During the reduction of Cu2+ to Cu+, the coordination geometry of copper changes...

Financial Derivatives

DEFF Research Database (Denmark)

Wigan, Duncan

2013-01-01

Contemporary derivatives mark the development of capital and constitute a novel form of ownership. By reconfiguring the temporal, spatial and legal character of ownership derivatives present a substantive challenge to the tax collecting state. While fiscal systems are nationally bounded...... and inherently static, capital itself is unprecedentedly mobile, fluid and fungible. As such derivatives raise the specter of ‘financial weapons of mass destruction’....

Interest rate derivatives

DEFF Research Database (Denmark)

Svenstrup, Mikkel

This Ph.D. thesis consists of four self-contained essays on valuation of interest rate derivatives. In particular derivatives related to management of interest rate risk care are considered.......This Ph.D. thesis consists of four self-contained essays on valuation of interest rate derivatives. In particular derivatives related to management of interest rate risk care are considered....

Deriving Langevin equations in curved spacetime

International Nuclear Information System (INIS)

Ramos, Rudnei O.; Tavares, Romulo F.

2013-01-01

Full text: Warm inflation is an inflationary scenario where the interactions between the inflaton and other degrees of freedom are considered. The effective equation of motion for the inflaton is in general of the form of a Langevin equation, that includes both quantum and thermal effects and where these effects manifest in the form of dissipation and stochastic noise terms, which are related by a generalized fluctuation-dissipation relation. The dissipation term is related to the interactions of the inflaton with other degrees of freedom of the thermal bath that can be obtained from the appropriate Feynman propagators. As the inflaton evolves into an expanding metric, these effects have to be taken into account when calculating the Green functions and consequently the Feynman propagators. In this work we present the considerations that must be made to calculate the Green functions in curved space (expanding metric) and in the presence of radiation in order to proper derive the effective evolution of the inflaton in the warm-inflation scenario. (author)

Gender matters: the relationship between social anxiety and alcohol-related consequences.

Directory of Open Access Journals (Sweden)

Amie R Schry

Full Text Available BACKGROUND AND OBJECTIVES: Identification of risk factors for alcohol-related consequences is an important public health concern. Both gender and social anxiety have been associated with alcohol-related consequences broadly, but it is unknown whether these variables are differentially related to specific types of alcohol-related consequences for American college students. METHODS: In the present study, 573 undergraduate students (M(age = 19.86 years, SD = 1.40; range 18 to 25; 68.9% female completed an on-line assessment of social anxiety, alcohol use, and four types of alcohol-related consequences (personal, social, physical, and role. Poisson regressions were run to examine social anxiety, gender, and the interaction between social anxiety and gender as predictors of each type of alcohol-related consequences. RESULTS: After controlling for alcohol use, social anxiety was positively associated with all four types of consequences, and females endorsed higher rates of physical, personal, and role consequences. The interaction between social anxiety and gender was statistically significant only for physical consequences, with social anxiety having a stronger effect for males. DISCUSSION AND CONCLUSIONS: These findings, which diverge somewhat from those of a prior study with Australian college students, are discussed in the context of a biopsychosocial model of social anxiety and substance use problems. SCIENTIFIC SIGNIFICANCE: This study highlights the importance of further investigating cultural differences in the relationships among social anxiety, gender, and alcohol-related consequences.

Gender Matters: The Relationship between Social Anxiety and Alcohol-Related Consequences

Science.gov (United States)

Schry, Amie R.; Norberg, Melissa M.; Maddox, Brenna B.; White, Susan W.

2014-01-01

Background and Objectives Identification of risk factors for alcohol-related consequences is an important public health concern. Both gender and social anxiety have been associated with alcohol-related consequences broadly, but it is unknown whether these variables are differentially related to specific types of alcohol-related consequences for American college students. Methods In the present study, 573 undergraduate students (M age = 19.86 years, SD = 1.40; range 18 to 25; 68.9% female) completed an on-line assessment of social anxiety, alcohol use, and four types of alcohol-related consequences (personal, social, physical, and role). Poisson regressions were run to examine social anxiety, gender, and the interaction between social anxiety and gender as predictors of each type of alcohol-related consequences. Results After controlling for alcohol use, social anxiety was positively associated with all four types of consequences, and females endorsed higher rates of physical, personal, and role consequences. The interaction between social anxiety and gender was statistically significant only for physical consequences, with social anxiety having a stronger effect for males. Discussion and Conclusions These findings, which diverge somewhat from those of a prior study with Australian college students, are discussed in the context of a biopsychosocial model of social anxiety and substance use problems. Scientific Significance This study highlights the importance of further investigating cultural differences in the relationships among social anxiety, gender, and alcohol-related consequences. PMID:25541722

The Chernobyl accident consequences

International Nuclear Information System (INIS)

2001-04-01

Five teen years later, Tchernobyl remains the symbol of the greater industrial nuclear accident. To take stock on this accident, this paper proposes a chronology of the events and presents the opinion of many international and national organizations. It provides also web sites references concerning the environmental and sanitary consequences of the Tchernobyl accident, the economic actions and propositions for the nuclear safety improvement in the East Europe. (A.L.B.)

Tryptophan derivatives regulate the transcription of Oct4 in stem-like cancer cells.

Science.gov (United States)

Cheng, Jie; Li, Wenxin; Kang, Bo; Zhou, Yanwen; Song, Jiasheng; Dan, Songsong; Yang, Ying; Zhang, Xiaoqian; Li, Jingchao; Yin, Shengyong; Cao, Hongcui; Yao, Hangping; Zhu, Chenggang; Yi, Wen; Zhao, Qingwei; Xu, Xiaowei; Zheng, Min; Zheng, Shusen; Li, Lanjuan; Shen, Binghui; Wang, Ying-Jie

2015-06-10

The aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor that responds to environmental toxicants, is increasingly recognized as a key player in embryogenesis and tumorigenesis. Here we show that a variety of tryptophan derivatives that act as endogenous AhR ligands can affect the transcription level of the master pluripotency factor Oct4. Among them, ITE enhances the binding of the AhR to the promoter of Oct4 and suppresses its transcription. Reduction of endogenous ITE levels in cancer cells by tryptophan deprivation or hypoxia leads to Oct4 elevation, which can be reverted by administration with synthetic ITE. Consequently, synthetic ITE induces the differentiation of stem-like cancer cells and reduces their tumorigenic potential in both subcutaneous and orthotopic xenograft tumour models. Thus, our results reveal a role of tryptophan derivatives and the AhR signalling pathway in regulating cancer cell stemness and open a new therapeutic avenue to target stem-like cancer cells.

Environmental Degradation: Causes and Consequences

Directory of Open Access Journals (Sweden)

Swati Tyagi

2014-08-01

Full Text Available The subject of environmental economics is at the forefront of the green debate: the environment can no longer be viewed as an entity separate from the economy. Environmental degradation is of many types and have many consequences. To address this challenge a number of studies have been conducted in both developing and developed countries applying different methods to capture health benefits from improved environmental quality. Minimizing exposure to environmental risk factors by enhancing air quality and access to improved sources of drinking and bathing water, sanitation and clean energy is found to be associated with significant health benefits and can contribute significantly to the achievement of the Millennium Development Goals of environmental sustainability, health and development. In this paper, I describe the national and global causes and consequences of environmental degradation and social injustice. This paper provides a review of the literature on studies associated with reduced environmental risk and in particular focusing on reduced air pollution, enhanced water quality and climate change mitigation.

The economic consequences of elevated body-lead burdens in urban children

International Nuclear Information System (INIS)

Agree, M.D.

1991-01-01

The following analysis develops the theory and implementation of the observed behavior technique in an altruistic setting, to assess the health benefits of reducing environmental lead exposure in urban children. Three models are presented which allow for endogenous body lead burden, risk of irreversible neurological damages, and Bayesian information. Conditions are derived under which the observed behavior technique can be modified to value the health consequences of exposure to a general class of persistent micropollutants (PMP's): the heavy metals. Benefit expressions reflect the tradeoff between parental wealth and child health when children are exposed to low level doses of lead. The purpose is to derive exact measures of marginal welfare change associated with variations in child body lead burden, and to determine the conditions under which these measures will be functions of observable parameters. The analysis presents an entirely ex ante approach to the recovery of benefit estimates when PMP exposure involves risk of irreversible health damages. In doing so, an empirical estimate is also obtained for the parental value of child health information that is used in the revision of prior risk beliefs. Risk of chronic irreversible health effects in younger generations from environmental lead exposure may be experienced by a large share of metropolitan population in the US. Given the large numbers of possible victims, the aggregate social value of avoiding this risk is an important policy issues. Moreover, the value of health risk information is potentially important to the use of an information program as a policy instrument in reducing health risk because it would enable the comparison of societal benefits from an information program to the cost of it's implementation

Short, medium and long term consequences of inadequate defect fuel management

Energy Technology Data Exchange (ETDEWEB)

Roberts, J.G. [CANTECH Associates Limited, Burlington, Ontario (Canada); Nashiem, R.; McQueen, M.; Ma, G. [Bruce Power, Tiverton, Ontario (Canada)

2011-07-01

Defect fuel pencils result in short, medium and long term consequences to the environment within and external to the nuclear power station. The paper will describe these consequences and specify the Defect Fuel Management Practices required to avoid these consequences. (author)

Short, medium and long term consequences of inadequate defect fuel management

International Nuclear Information System (INIS)

Roberts, J.G.; Nashiem, R.; McQueen, M.; Ma, G.

2011-01-01

Defect fuel pencils result in short, medium and long term consequences to the environment within and external to the nuclear power station. The paper will describe these consequences and specify the Defect Fuel Management Practices required to avoid these consequences. (author)

Short, medium and long term consequences of inadequate defect fuel management

International Nuclear Information System (INIS)

Roberts, J.G.; McQueen, M.; Nashiem, R.; Ma, G.

2011-01-01

Defect fuel pencils result in short, medium and long term consequences to the environment within and external to the nuclear power station. The paper will describe these consequences and specify the Defect Fuel Management Practices required to avoid these consequences.

Short, medium and long term consequences of inadequate defect fuel management

Energy Technology Data Exchange (ETDEWEB)

Roberts, J.G. [CANTECH Associates Ltd., Burlington, ON (Canada); McQueen, M.; Nashiem, R.; Ma, G. [Bruce Power, Tiverton, ON (Canada)

2011-07-01

Defect fuel pencils result in short, medium and long term consequences to the environment within and external to the nuclear power station. The paper will describe these consequences and specify the Defect Fuel Management Practices required to avoid these consequences.

Short, medium and long term consequences of inadequate defect fuel management

Energy Technology Data Exchange (ETDEWEB)

Roberts, J.G., E-mail: alchemy@tnt21.com [CANTECH Associates Ltd., Burlington, Ontario (Canada); Nashiem, R.; McQueen, M.; Ma, G., E-mail: Rod.nashiem@brucepower.com, E-mail: Maureen.mcqueen@brucepower.com, E-mail: guoping.ma@brucepower.com [Bruce Power, Tiverton (Canada)

2010-07-01

Defect fuel pencils result in short, medium and long term consequences to the environment within and external to the nuclear power station. The paper will describe these consequences and specify the Defect Fuel Management Practices required to avoid these consequences. (author)

Short, medium and long term consequences of inadequate defect fuel management

International Nuclear Information System (INIS)

Roberts, J.G.; Nashiem, R.; McQueen, M.; Ma, G.

2010-01-01

Defect fuel pencils result in short, medium and long term consequences to the environment within and external to the nuclear power station. The paper will describe these consequences and specify the Defect Fuel Management Practices required to avoid these consequences. (author)

Consequences of dispersal of a radioactive source

International Nuclear Information System (INIS)

Chester, R.O.; Chester, C.V.

1978-01-01

The purpose of this study is to examine the question of whether the risk and consequences of theft or sabotage of facilities or vehicles containing small quantities of SNM, source, and by-product materials are such that licensees should be required to adopt further measures to safeguard them. In the course of the study an assessment will be made of the potential consequences of malevolent use of the referenced materials. To provide, these will be compared with the corresponding characteristics of non-nuclear materials such as chemical or biological agents

The Chernobyl nuclear accident and its consequences

International Nuclear Information System (INIS)

1986-01-01

An AAEC Task Group was set up shortly after the accident at the Chernobyl Nuclear Power Plant to monitor and evaluate initial reports and to assess the implications for Australia. The Task Group issued a preliminary report on 9 May 1986. On 25-29 August 1986, the USSR released details of the accident and its consequences and further information has become available from the Nuclear Energy Agency of OECD and the World Health Organisation. The Task Group now presents a revised report summarising this information and commenting on the consequences from the Australian viewpoint

77 FR 5281 - State-of-the-Art Reactor Consequence Analyses Reports

Science.gov (United States)

2012-02-02

... NUCLEAR REGULATORY COMMISSION [Docket ID: NRC-2012-0022] State-of-the-Art Reactor Consequence... release of Draft NUREG-1935, ``State-of-the-Art Reactor Consequence Analyses (SOARCA) Report,'' for public... offsite radiological health consequences for potential severe reactor accidents for the Peach Bottom...

The medical consequences of nuclear weapons

International Nuclear Information System (INIS)

Humphrey, J.; Hartog, M.; Middleton, H.

1982-01-01

A pamphlet has been produced by the Medical Campaign Against Nuclear Weapons (MCANW) and by the Medical Association for the Prevention of War (MAPW) to bring the catastrophic effects that the use of nuclear weapons would entail to the attention of the general public, politicians and members of the medical profession. It describes the medical consequences of the effects of blast, heat and ionizing radiation from nuclear weapons, including details from the Hiroshima and Nagasaki atomic bombings. The medical consequences of a nuclear attack including consideration of the casualties, care of the injured, psychological effects and the outcome are also discussed. It is concluded that if for none other than purely medical reasons, nuclear warfare must never be allowed to happen. (UK)

[Climate change - physical and mental consequences].

Science.gov (United States)

Bunz, Maxie; Mücke, Hans-Guido

2017-06-01

Climate change has already had a large influence on the human environmental system and directly or indirectly affects physical and mental health. Triggered by extreme meteorological conditions, for example, storms, floods, earth slides and heat periods, the direct consequences range from illnesses to serious accidents with injuries, or in extreme cases fatalities. Indirectly, a changed environment due to climate change affects, amongst other things, the cardiovascular system and respiratory tract, and can also cause allergies and infectious diseases. In addition, increasing confrontation with environmental impacts may cause negative psychological effects such as posttraumatic stress disorders and anxiety, but also aggression, distress and depressive symptoms. The extent and severity of the health consequences depend on individual pre-disposition, resilience, behaviour and adaptation.

Prospect Theory: Contributions to Understanding Actors, Causes and Consequences of Conflict in Africa

Directory of Open Access Journals (Sweden)

Wendy Trott

2013-08-01

Full Text Available Despite many recognized shortcomings, Rational Choice Theory remains the dominant perspective on decision-making in the literature on African conflict, whether overtly acknowledged or not. Prospect Theory, originally derived from the field of behavioural economics, can complement and advance this perspective not only by explaining the behaviour of actors, but also by allowing for predictions and the devising of strategies to avoid or end on-going conflicts based on a set of systematic biases that influence how actors make decisions. After a brief definition of Prospect Theory, this work will begin with an overview of the existing literature on decision-making as it relates to conflict, examine how Rational Choice is inadequate in explaining much human behaviour and thus how Prospect Theory can fill this gap. It will then move on to give a fuller definition of the various hypotheses derived from Prospect Theory that pertain to the study of conflict. An example of the application of Prospect Theory to a related field in which thorough research has been conducted, Deterrence Theory, will be used to demonstrate the model’s potential for study in other areas. This will be followed by a more in-depth analysis of the ways in which Prospect Theory can contribute to understanding the behaviour of actors in war, the causes of conflict, and the consequences in the African context. It will conclude with a summary and proposition for further research that can advance this analysis.

Consequences of potential accidents in heavy water plants

International Nuclear Information System (INIS)

Croitoru, C.; Lazar, R.E.; Preda, I.A.; Dumitrescu, M.

2002-01-01

Heavy water plants achieve the primary isotopic concentration by H 2 O-H 2 S chemical exchange. In these plants are stored large quantities of hydrogen sulphide (high toxic, corrosive, flammable and explosive) maintained in process at relative high temperatures and pressures. It is required an assessment of risks associated with the potential accidents. The paper presents adopted model for quantitative consequences assessment in heavy water plants. Following five basic steps are used to identify the risks involved in plants operation: hazard identification, accident sequences development, H 2 S emissions calculus, dispersion analyses and consequences determination. A brief description of each step and some information from risk assessment for our heavy water pilot plant are provided. Accident magnitude, atmospheric conditions and population density in studied area were accounted for consequences calculus. (author)

Evaluation of atmospheric dispersion/consequence models supporting safety analysis

International Nuclear Information System (INIS)

O'Kula, K.R.; Lazaro, M.A.; Woodard, K.

1996-01-01

Two DOE Working Groups have completed evaluation of accident phenomenology and consequence methodologies used to support DOE facility safety documentation. The independent evaluations each concluded that no one computer model adequately addresses all accident and atmospheric release conditions. MACCS2, MATHEW/ADPIC, TRAC RA/HA, and COSYMA are adequate for most radiological dispersion and consequence needs. ALOHA, DEGADIS, HGSYSTEM, TSCREEN, and SLAB are recommended for chemical dispersion and consequence applications. Additional work is suggested, principally in evaluation of new models, targeting certain models for continued development, training, and establishing a Web page for guidance to safety analysts

The Consequences of Consequential Validity.

Science.gov (United States)

Mehrens, William A.

1997-01-01

There is no agreement at present about the importance or meaning of the term "consequential validity." It is important that the authors of revisions to the "Standards for Educational and Psychological Testing" recognize the debate and relegate discussion of consequences to a context separate from the discussion of validity.…

The consequences of a reduction in the administratively applied maximum annual dose equivalent level for an individual in a group of occupationally exposed workers

International Nuclear Information System (INIS)

Harrison, N.T.

1980-02-01

An analysis is described for predicting the consequences of a reduction in the administratively applied maximum dose equivalent level to individuals in a group of workers occupationally exposed to ionising radiations, for the situation in which no changes are made to the working environment. This limitation of the maximum individual dose equivalent is accommodated by allowing the number of individuals in the working group to increase. The derivation of the analysis is given, together with worked examples, which highlight the important assumptions that have been made and the conclusions that can be drawn. The results are obtained in the form of the capacity of the particular working environment to accommodate the limitation of the maximum individual dose equivalent, the increase in the number of workers required to carry out the productive work and any consequent increase in the occupational collective dose equivalent. (author)

[Neuroticism, work demands, work-family conflict and job stress consequences].

Science.gov (United States)

Lachowska, Bogusława Halina

2014-01-01

The objective of the study was to the determine of neuroticism, requirements of the labor market and work-family conflict while exploring consequences of various aspects of job stress in occupationally active parents. The investigations covered 159 females and 154 males from families where both parents are occupationally active and bring up at least one child aged up to 12 years. The following consequences of occupational stress were analyzed: the state of psychological health self-reported by the employees (symptoms of somatic disorders, anxiety and insomnia, functioning disorders, symptoms of depression, global distress), as well as distress experienced at work, employee intention to turnover, and job satisfaction. The importance of neuroticism, work demands, and work-family conflict varies when explaining individual consequences of job stress. Of all the predictors analyzed, neuroticism is significantly correlated with the majority of consequences. Having considered the importance of work-family conflict, the role of work demands in understanding various consequences of job stress is much lower or even statistically insignificant. The construction of complex theoretical models, taking account of a wide range of factors related with the sphere of occupational activity, the role of work-family conflict and individual factors, allow for a better understanding of the determinants of job stress and its consequences.

Cosyma a new programme package for accident consequence assessment

International Nuclear Information System (INIS)

Kelly, G.N.

1991-01-01

This report gives details of a new programme package for accident consequence assessment, prepared under the CEC's Maria programme (Methods for assessing the radiological impact of accidents) initiated in 1982 to review and build on the nuclear accident consequence assessment methods in use within the European Community

The potential for reducing the radiological consequences of reactor decommissioning through selection of construction materials for activated components

International Nuclear Information System (INIS)

Woollam, P.B.

1984-08-01

This report considers whether it may be possible to reduce the radiological consequences of reactor decommissioning by careful attention to the specification of the elemental concentration of materials used in the reactor's construction. In particular, consideration is given to the potential for reduction of the concentration of elements known to activate to long lived daughter isotopes. Two particular areas are addressed, both applied to Sizewell 'B' PWR. The first is the choice of raw materials for the construction of the concrete bioshield to minimise future waste arisings. The second is the specification of some trace element concentrations in the steel pressure vessel and reactor internal structures to minimise personnel exposure at decommissioning time. The report presents extensive analyses of many of the candidate raw materials for Sizewell 'B' concrete, including PFA, and derives the radiological consequences for the eventual disposal of these materials to a hypothetical municipal land fill waste site. Data are also presented on the concentrations of important elements activating to gamma emitting daughters in type 304 stainless steels, leading to an assessment of likely dose equivalent rates at decommissioning time from the pressure vessel and from the internal components. (author)

Financial Derivatives

OpenAIRE

Janečková, Alena

2011-01-01

1 Abstract/ Financial derivatives The purpose of this thesis is to provide an introduction to financial derivatives which has been, from the legal perspective, described in a not satisfactory manner as quite little literature that can be found about this topic. The main objectives of this thesis are to define the term "financial derivatives" and its particular types and to analyse legal nature of these financial instruments. The last objective is to try to draft future law regulation of finan...

Consequences attributed to kidney transplantation: critical incident technique

OpenAIRE

Santos,Bianca Pozza dos; Schwartz,Eda; Beuter,Margrid; Muniz,Rosani Manfrin; Echevarría-Guanilo,Maria Elena; Viegas,Aline da Costa

2015-01-01

This study aimed to describe the consequences experienced in the life of a person with kidney transplantation. This is a descriptive and qualitative approach, using the Critical Incident Technique, in which the interview content was analyzed, in an attempt to isolate the consequences of the kidney transplantation, showing positive and/or negative references. When confronted with what kidney transplantation provided to people's life, the independence from the hemodialysis machine, the existenc...

Short-sighted confession decisions: the role of uncertain and delayed consequences.

Science.gov (United States)

Yang, Yueran; Madon, Stephanie; Guyll, Max

2015-02-01

Suspects have a propensity to focus on short-term contingencies, giving disproportionate weight to the proximal consequences that are delivered by police during an interrogation, and too little consideration to the distal (and often more severe) consequences that may be levied by the judicial system if they are convicted. In this research, the authors examined whether the perceived uncertainty and temporal distance of distal consequences contribute to this propensity. Using the repetitive question paradigm (Madon et al., 2012), participants (N = 209) were interviewed about 20 prior criminal and unethical behaviors and were required to admit or deny each one. Participants' denials and admissions were paired with both a proximal consequence and a distal consequence, respectively. Results indicated that the distal consequence had less impact on participants' admission decisions when it was uncertain and temporally remote. These results provide evidence that the perceived uncertainty and temporal distance of future punishment are key factors that lead suspects to confess to crimes in exchange for short-term gains.

Probabilistic Accident Consequence Uncertainty - A Joint CEC/USNRC Study

International Nuclear Information System (INIS)

Gregory, Julie J.; Harper, Frederick T.

1999-01-01

The joint USNRC/CEC consequence uncertainty study was chartered after the development of two new probabilistic accident consequence codes, MACCS in the U.S. and COSYMA in Europe. Both the USNRC and CEC had a vested interest in expanding the knowledge base of the uncertainty associated with consequence modeling, and teamed up to co-sponsor a consequence uncertainty study. The information acquired from the study was expected to provide understanding of the strengths and weaknesses of current models as well as a basis for direction of future research. This paper looks at the elicitation process implemented in the joint study and discusses some of the uncertainty distributions provided by eight panels of experts from the U.S. and Europe that were convened to provide responses to the elicitation. The phenomenological areas addressed by the expert panels include atmospheric dispersion and deposition, deposited material and external doses, food chain, early health effects, late health effects and internal dosimetry

Probabilistic Accident Consequence Uncertainty - A Joint CEC/USNRC Study

Energy Technology Data Exchange (ETDEWEB)

Gregory, Julie J.; Harper, Frederick T.

1999-07-28

The joint USNRC/CEC consequence uncertainty study was chartered after the development of two new probabilistic accident consequence codes, MACCS in the U.S. and COSYMA in Europe. Both the USNRC and CEC had a vested interest in expanding the knowledge base of the uncertainty associated with consequence modeling, and teamed up to co-sponsor a consequence uncertainty study. The information acquired from the study was expected to provide understanding of the strengths and weaknesses of current models as well as a basis for direction of future research. This paper looks at the elicitation process implemented in the joint study and discusses some of the uncertainty distributions provided by eight panels of experts from the U.S. and Europe that were convened to provide responses to the elicitation. The phenomenological areas addressed by the expert panels include atmospheric dispersion and deposition, deposited material and external doses, food chain, early health effects, late health effects and internal dosimetry.

Planning of elimination of emergency consequences

Directory of Open Access Journals (Sweden)

S. Kovalenko

2015-05-01

Full Text Available Introduction. The volume of useful information in the planning of elimination of emergency consequences process is reasonable to assess with calculatory problems and mathematical models. Materials and methods. The expert survey method is used to calculate quantitative values of probability and to determine the optimal solution before the information in condition is received. Results. It is determined that the quality of the solution of elimination emergency consequences depends primarily on the number of factors that are taken into account in particular circumstances of the situation; on the level of information readiness of control bodies to take decision to eliminate emergency consequences as soon as possible and to consider several options for achieving reasonableness and concreteness of a particular decision. The ratio between volume of useful information collected and processed during operation planning which is required for identifying optimal solution is calculated. This ratio allows to construct a graph of probability of identifying a solution in existing environment and probability value of identifying optimal solution before information in P*condition is obtained. This graph also shows the ratio volume of useful information collected and processed during operation planning and necessary volume of information for identifying optimal solution. Conclusion. The results of this research can be used for improving control bodies decisions to ensure safe working conditions for employees of food industry.

Functional Studies of Missense TREM2 Mutations in Human Stem Cell-Derived Microglia

Directory of Open Access Journals (Sweden)

Philip W. Brownjohn

2018-04-01

Full Text Available Summary: The derivation of microglia from human stem cells provides systems for understanding microglial biology and enables functional studies of disease-causing mutations. We describe a robust method for the derivation of human microglia from stem cells, which are phenotypically and functionally comparable with primary microglia. We used stem cell-derived microglia to study the consequences of missense mutations in the microglial-expressed protein triggering receptor expressed on myeloid cells 2 (TREM2, which are causal for frontotemporal dementia-like syndrome and Nasu-Hakola disease. We find that mutant TREM2 accumulates in its immature form, does not undergo typical proteolysis, and is not trafficked to the plasma membrane. However, in the absence of plasma membrane TREM2, microglia differentiate normally, respond to stimulation with lipopolysaccharide, and are phagocytically competent. These data indicate that dementia-associated TREM2 mutations have subtle effects on microglia biology, consistent with the adult onset of disease in individuals with these mutations. : Brownjohn and colleagues report methods to generate microglia from induced pluripotent human stem cells, which they demonstrate are highly similar to cultured primary human microglia. Microglia differentiated from patient-derived stem cells carrying neurological disease-causing mutations in the TREM2 receptor differentiate normally and respond appropriately to pathogenic stimuli, despite the absence of functional TREM2 receptor on the plasma membrane. Keywords: dementia, microglia, TREM2, Nasu-Hakola disease, frontotemporal dementia, iPSC-microglia, neuroinflammation

The psychosocial consequences of spent fuel disposal

International Nuclear Information System (INIS)

Paavola, J.; Eraenen, L.

1999-03-01

In this report the potential psychosocial consequences of spent fuel disposal to inhabitants of a community are assessed on the basis of earlier research. In studying the situation, different interpretations and meanings given to nuclear power are considered. First, spent fuel disposal is studied as fear-arousing and consequently stressful situation. Psychosomatic effects of stress and coping strategies used by an individual are presented. Stress as a collective phenomenon and coping mechanisms available for a community are also assessed. Stress reactions caused by natural disasters and technological disasters are compared. Consequences of nuclear power plant accidents are reviewed, e.g. research done on the accident at Three Mile Island power plant. Reasons for the disorganising effect on a community caused by a technological disaster are compared to the altruistic community often seen after natural disasters. The potential reactions that a spent fuel disposal plant can arouse in inhabitants are evaluated. Both short-term and long-term reactions are evaluated as well as reactions under normal functioning, after an incident and as a consequence of an accident. Finally an evaluation of how the decision-making system and citizens' opportunity to influence the decision-making affect the experience of threat is expressed. As a conclusion we see that spent fuel disposal can arouse fear and stress in people. However, the level of the stress is probably low. The stress is at strongest at the time of the starting of the spent fuel disposal plant. With time people get used to the presence of the plant and the threat experienced gets smaller. (orig.)

34 CFR 600.10 - Date, extent, duration, and consequence of eligibility.

Science.gov (United States)

2010-07-01

... 34 Education 3 2010-07-01 2010-07-01 false Date, extent, duration, and consequence of eligibility... EDUCATION ACT OF 1965, AS AMENDED General § 600.10 Date, extent, duration, and consequence of eligibility... statutory and regulatory requirements governing its eligibility. (e) Consequence of eligibility. (1) If, as...

Safety consequences of the release of radiation induced stored energy

International Nuclear Information System (INIS)

Prij, J.

1994-08-01

Due to the disposal of HLW in a salt formation gamma energy will be deposited in the rock salt. Most of this energy will be converted into heat, whilst a small part will create defects in the salt crystals. Energy is stored in the damaged crystals. Due to uncertainties in the models and differences in the disposal concepts the estimated values for the stored energy range from 10 to 1000 J/g in the most heavily damaged crystals close to the waste containers. The amount of radiation damage decays exponentially with increasing distance from the containers and at distances larger than 0.2 m the stored energy can be neglected. Given the uncertainties in the model predictions and in the possible release mechanism an instantaneous release of stored energy cannot be excluded completely. Therefore the thermo-mechanical consequences of a postulated instantaneous release of an extremely high amount of radiation induced stored energy have been estimated. These estimations are based on the quasi-static solutions for line and point sources. To account for the dynamic effects and the occurrence of fractures an amplification factor has been derived from mining experience with explosives. A validation of this amplification factor has been given using post experimental observations of two nuclear explosions in a salt formation. For some typical disposal concepts in rock salt the extent of the fractured zone has been estimated. It appeared that the radial extent of the fractured zone is limited to 5 m. Given the much larger distance between the individual boreholes and the distance between the boreholes and the boundary of the salt formation (more than 100 m), the probability of a release of radiation induced stored energy creating a pathway for the nuclides from the containers to the groundwater, is extremely low. The radiological consequences of a groundwater intrusion scenario induced by this very unprobable pathway are bounded by the 'standard' groundwater intrusion

Unintended Consequences of Wearable Sensor Use in Healthcare

Science.gov (United States)

McCaldin, D.; Wang, K.; Schreier, G.; Lovell, N. H.; Marschollek, M.; Redmond, S. J.

2016-01-01

Summary Objectives As wearable sensors take the consumer market by storm, and medical device manufacturers move to make their devices wireless and appropriate for ambulatory use, this revolution brings with it some unintended consequences, which we aim to discuss in this paper. Methods We discuss some important unintended consequences, both beneficial and unwanted, which relate to: modifications of behavior; creation and use of big data sets; new security vulnerabilities; and unforeseen challenges faced by regulatory authorities, struggling to keep pace with recent innovations. Where possible, we proposed potential solutions to unwanted consequences. Results Intelligent and inclusive design processes may mitigate unintended modifications in behavior. For big data, legislating access to and use of these data will be a legal and political challenge in the years ahead, as we trade the health benefits of wearable sensors against the risk to our privacy. The wireless and personal nature of wearable sensors also exposes them to a number of unique security vulnerabilities. Regulation plays an important role in managing these security risks, but also has the dual responsibility of ensuring that wearable devices are fit for purpose. However, the burden of validating the function and security of medical devices is becoming infeasible for regulators, given the many software apps and wearable sensors entering the market each year, which are only a subset of an even larger ‘internet of things’. Conclusion Wearable sensors may serve to improve wellbeing, but we must be vigilant against the occurrence of unintended consequences. With collaboration between device manufacturers, regulators, and end-users, we balance the risk of unintended consequences occurring against the incredible benefit that wearable sensors promise to bring to the world. PMID:27830234

Social consequences of closing the Ignalina NPP

International Nuclear Information System (INIS)

Baubinas, R.; Burneika, D.

2001-01-01

The possible social consequences of closing the Ignalina Nuclear Power Plant are studied. The social and economical situation in Visaginas and in the Utena region as a precondition for possible social consequences is shown. Also, two main groups of factors that can possibly influence the situation in the labour market are analysed. The problems of the enterprises that create working places and of the inhabitants of Visaginas whose possible behaviour can affect the situation in the labour market are discussed. Also, some proposals to neutralize the social costs of closing the Ignalina NPP are made. (author)

Violence and its injury consequences in American movies

Science.gov (United States)

McArthur, David L; Peek-Asa, Corinne; Webb, Theresa; Fisher, Kevin; Cook, Bernard; Browne, Nick; Kraus, Jess

2000-01-01

Objectives To evaluate the seriousness and frequency of violence and the degree of associated injury depicted in the 100 top-grossing American films of 1994. Methods Each scene in each film was examined for the presentation of violent actions on persons and coded by a systematic context-sensitive analytic scheme. Specific degrees of violence and indices of injury severity were abstracted. Only actually depicted, not implied, actions were coded, although both explicit and implied consequences were examined. Results The median number of violent actions per film was 16 (range, 0-110). Intentional violence outnumbered unintentional violence by a factor of 10. Almost 90% of violent actions showed no consequences to the recipient's body, although more than 80% of the violent actions were executed with lethal or moderate force. Fewer than 1% of violent actions were accompanied by injuries that were then medically attended. Conclusions Violent force in American films of 1994 was overwhelmingly intentional and in 4 of 5 cases was executed at levels likely to cause significant bodily injury. Not only action films but movies of all genres contained scenes in which the intensity of the action was not matched by correspondingly severe injury consequences. Many American films, regardless of genre, tend to minimize the consequences of violence to human beings. PMID:10986175

Malabsorption: causes, consequences, diagnosis and treatment

African Journals Online (AJOL)

2011-06-06

Jun 6, 2011 ... Review Article: Malabsorption: causes, consequences, diagnosis and treatment. 2011;24(3) ... and osteopenia (malabsorption of calcium, vitamin D, phosphate and magnesium .... A lipase dosage in excess of 75 000 IU per.

Long-term Consequences of Early Parenthood

DEFF Research Database (Denmark)

Johansen, Eva Rye; Nielsen, Helena Skyt; Verner, Mette

(and to lesser extent employment), as fathers appear to support the family, especially when early parenthood is combined with cohabitation with the mother and the child. Heterogeneous effects reveal that individuals with a more favorable socioeconomic background are affected more severely than......Having children at an early age is known to be associated with unfavorable economic outcomes, such as lower education, employment and earnings. In this paper, we study the long-term consequences of early parenthood for mothers and fathers. Our study is based on rich register-based data that......, importantly, merges all childbirths to the children’s mothers and fathers, allowing us to study the consequences of early parenthood for both parents. We perform a sibling fixed effects analysis in order to account for unobserved family attributes that are possibly correlated with early parenthood...

21 CFR 184.1685 - Rennet (animal-derived) and chymosin preparation (fermentation-derived).

Science.gov (United States)

2010-04-01

... (fermentation-derived). 184.1685 Section 184.1685 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF... (animal-derived) and chymosin preparation (fermentation-derived). (a)(1) Rennet and bovine rennet are... clear solution containing the active enzyme chymosin (E.C. 3.4.23.4). It is derived, via fermentation...

Derivation of recommended limits for radionuclide contamination of foods by the FAO

International Nuclear Information System (INIS)

Wirth, E.; Mueller, M.K.

1986-01-01

As a consequence of the reactor accident at Chernobyl, USSR, various countries defined limits for radioactive contamination of foods at different levels. These limits ranged from a few Bq iodine 131 or cesium 134 + 137/kg (Malaysia and Canada) to more than 1000 Bq/kg (Great Britain and France). These variations in limits hindered the movement of foods in international trade. For this reason the FAO convened an Expert Consultation to derive 'action levels' below which neither intervention nor constraint would be justified in terms of international movement and trade in food and drink. These limits are to find application in cases of widespread environmental contamination after an accidental release of radionuclides. They are not to be applied in cases of local release, e.g. in the vicinity of nuclear facilities. The derivation of 'action levels' by the FAO was based on the recommendations issued by the International Commission of Radiological Protection (ICRP) in May 1985. According to this recommendation the committed dose equivalent for the whole body should not exceed 5 mSv in the first and 1 mSv in the consecutive years. For radionuclides that preferentially irradiate individual organs, e.g. I131 in the thyroid, the dose equivalent to a specified organ may be used to derive limiting values. For individual organs limiting doses of 50 mSv/a and 10 mSv/a respectively were chosen

Derivation of recommended limits for radionuclide contamination of foods by the FAO

Energy Technology Data Exchange (ETDEWEB)

Wirth, E; Mueller, M K [Institute for Radiation Hygiene, Federal Health Office, Neuherberg (Germany)

1986-07-01

As a consequence of the reactor accident at Chernobyl, USSR, various countries defined limits for radioactive contamination of foods at different levels. These limits ranged from a few Bq iodine 131 or cesium 134 + 137/kg (Malaysia and Canada) to more than 1000 Bq/kg (Great Britain and France). These variations in limits hindered the movement of foods in international trade. For this reason the FAO convened an Expert Consultation to derive 'action levels' below which neither intervention nor constraint would be justified in terms of international movement and trade in food and drink. These limits are to find application in cases of widespread environmental contamination after an accidental release of radionuclides. They are not to be applied in cases of local release, e.g. in the vicinity of nuclear facilities. The derivation of 'action levels' by the FAO was based on the recommendations issued by the International Commission of Radiological Protection (ICRP) in May 1985. According to this recommendation the committed dose equivalent for the whole body should not exceed 5 mSv in the first and 1 mSv in the consecutive years. For radionuclides that preferentially irradiate individual organs, e.g. I131 in the thyroid, the dose equivalent to a specified organ may be used to derive limiting values. For individual organs limiting doses of 50 mSv/a and 10 mSv/a respectively were chosen.

Adverse consequences of student drinking: the role of sex, social anxiety, drinking motives.

Science.gov (United States)

Norberg, Melissa M; Olivier, Jake; Alperstein, Dion M; Zvolensky, Michael J; Norton, Alice R

2011-08-01

This study examined whether biological sex, social anxiety, and drinking motives relate differently to distinct types of alcohol-related consequences using Poisson regression. One hundred eighteen college students completed self-report measures assessing drinking motives and social anxiety and an interview assessing alcohol consumption and consequences. Highly socially anxious women were particularly apt to experience adverse role functioning consequences, while men were particularly apt to experience physical consequences. Although highly socially anxious women reported more personal consequences than did women with low to moderate social anxiety, men with low to moderate social anxiety reported experiencing more social and personal consequences than did women with low to moderate social anxiety. When taking into consideration the above associations, coping motives were statistically associated with social consequences and marginally related to personal consequences, while enhancement motives were significantly associated with physical consequences. Targeting these factors may lead to effective interventions for individuals with co-occurring social anxiety and drinking problems. Copyright © 2011 Elsevier Ltd. All rights reserved.

Biologically stable [18F]-labeled benzylfluoride derivatives

International Nuclear Information System (INIS)

Magata, Yasuhiro; Lang, Lixin; Kiesewetter, Dale O.; Jagoda, Elaine M.; Channing, Michael A.; Eckelman, William C.

2000-01-01

Use of the [ 18 F]-fluoromethyl phenyl group is an attractive alternative to direct fluorination of phenyl groups because the fluorination of the methyl group takes place under milder reaction conditions. However, we have found that 4-FMeBWAY showed femur uptake equal to that of fluoride up to 30 min in rat whereas 4-FMeQNB had a significantly lower percent injected dose per gram in femur up to 120 min. For these and other benzylfluoride derivatives, there was no clear in vivo structure-defluorination relationship. Because benzylchlorides (BzCls) are known alkylating agents, benzylfluorides may be alkylating agents as well, which may be the mechanism of defluorination. On this basis, the effects of substitution on chemical stability were evaluated by the 4-(4-nitro-benzyl)-pyridine (NBP) test, which is used to estimate alkylating activity with NBP. The effect of substitution on the alkylating activity was evaluated for nine BzCl derivatives: BzCl; 3- or 4-methoxy (electron donation) substituted BzCl; 2-, 3-, or 4-nitro (electron withdrawing) substituted BzCl; and 2-, 3-, or 4-chloro (electron withdrawing) substituted BzCl. Taken together, the alkylating reactivity of 3-chloro-BzCl was the weakest. This result was then applied to [ 18 F]-benzylfluoride derivatives and in vivo and in vitro stability were evaluated. Consequently, 3-chloro-[ 18 F]-benzylfluoride showed a 70-80% decrease of defluorination in both experiments in comparison with [ 18 F]-benzylfluoride, as expected. Moreover, a good linear relationship between in vivo femur uptake and in vitro hepatocyte metabolism was observed with seven 18 F-labeled radiopharmaceuticals, which were benzylfluorides, alkylfluorides, and arylfluorides. Apparently, the [ 18 F]-fluoride ion is released by metabolism in the liver in vivo. In conclusion, 3-chloro substituted BzCls are the most stable, which suggests that 3-chloro benzylfluorides will be the most chemically stable compound. This result should be important in

Stochastic Consequence Analysis for Waste Leaks

International Nuclear Information System (INIS)

HEY, B.E.

2000-01-01

This analysis evaluates the radiological consequences of potential Hanford Tank Farm waste transfer leaks. These include ex-tank leaks into structures, underneath the soil, and exposed to the atmosphere. It also includes potential misroutes, tank overflow

Neuroticism, work demands, work-family conflict and job stress consequences

Directory of Open Access Journals (Sweden)

Bogusława Halina Lachowska

2014-06-01

Full Text Available Background: The objective of the study was to the determine of neuroticism, requirements of the labor market and work-family conflict while exploring consequences of various aspects of job stress in occupationally active parents. Material and Methods: The investigations covered 159 females and 154 males from families where both parents are occupationally active and bring up at least one child aged up to 12 years. The following consequences of occupational stress were analyzed: the state of psychological health self-reported by the employees (symptoms of somatic disorders, anxiety and insomnia, functioning disorders, symptoms of depression, global distress, as well as distress experienced at work, employee intention to turnover, and job satisfaction. Results: The importance of neuroticism, work demands, and work-family conflict varies when explaining individual consequences of job stress. Of all the predictors analyzed, neuroticism is significantly correlated with the majority of consequences. Having considered the importance of work-family conflict, the role of work demands in understanding various consequences of job stress is much lower or even statistically insignificant. Conclusions: The construction of complex theoretical models, taking account of a wide range of factors related with the sphere of occupational activity, the role of work-family conflict and individual factors, allow for a better understanding of the determinants of job stress and its consequences. Med Pr 2014;65(3:387–398

42 CFR 60.36 - Consequence of using an agent.

Science.gov (United States)

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Consequence of using an agent. 60.36 Section 60.36 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS HEALTH EDUCATION ASSISTANCE LOAN PROGRAM The Lender and Holder § 60.36 Consequence of using an agent. The delegation of...

Challenges and Consequences of Reduced Skilled Nursing Facility Lengths of Stay.

Science.gov (United States)

Tyler, Denise A; McHugh, John P; Shield, Renée R; Winblad, Ulrika; Gadbois, Emily A; Mor, Vincent

2018-06-05

To identify the challenges that reductions in length of stay (LOS) pose for skilled nursing facilities (SNFs) and their postacute care (PAC) patients. Seventy interviews with staff in 25 SNFs in eight U.S. cities, LOS data for patients in those SNFs. Data were qualitatively analyzed, and key themes were identified. Interview data from SNFs with and without reductions in median risk-adjusted LOS were compared and contrasted. We conducted 70 semistructured interviews. LOS data were derived from minimum dataset (MDS) admission records available for all patients in all U.S. SNFs from 2012 to 2014. Challenges reported regardless of reductions in LOS included frequent and more complicated re-authorization processes, patients becoming responsible for costs, and discharging patients whom staff felt were unsafe at home. Challenges related to reduced LOS included SNFs being pressured to discharge patients within certain time limits. Some SNFs reported instituting programs and processes for following up with patients after discharge. These programs helped alleviate concerns about patients, but they resulted in nonreimbursable costs for facilities. The push for shorter LOS has resulted in unexpected challenges and costs for SNFs and possible unintended consequences for PAC patients. © Health Research and Educational Trust.

Dark matter and gas density profiles - a consequence of entropy bifurcation

International Nuclear Information System (INIS)

Leubner, M. P.

2006-01-01

The radial profiles of dark matter and hot plasma density distributions of relaxed galaxies and clusters were hitherto commonly fitted by empirical functions. On the other hand, the fundamental concept of non-extensive statistics accounts for long-range interactions and correlations present in gravitationally coupled ensembles and plasmas. We provide a theoretical link of non-extensive statistics to large scale astrophysical structures and show that the underlying tandem character of the entropy results in a bifurcation of the density distribution. A kinetic dark matter and thermodynamic gas branch turn out as natural consequence within the theory and is controlled by one single parameter, measuring physically the degree of correlations in the system. The theoretically derived density profiles are shown to represent accurately the characteristics of both, DM and hot plasma distributions, as observed or generated in N-body and hydro-simulations. The significant advantage over empirical fitting functions is provided by the physical content of the non-extensive approach wherefore it is proposed to model observed density profiles of astrophysical structures within the fundamental context of entropy generalization, accounting for nonlocality and long-range interactions in gravitationally coupled systems

Macroeconomic consequences of gender discrimination: a preliminary approach

OpenAIRE

Fernandez, Melchor; Pena-Boquete, Yolanda

2010-01-01

Although the degree of gender wage discrimination has been estimated many times, its effects on the economy have not been too much studied, neither theoretically nor empirically. Consequently, in this paper we attempt to cover the existent void in this topic. First, we establish a theoretically framework of the macroeconomic consequences of gender discrimination and second, we attempt to check these results empirically. The existence of a degree of discrimination means that there is a wage di...

Virtual reality - aesthetic consequences

OpenAIRE

Benda, Lubor

2014-01-01

In the present work we study aesthetic consequences of virtual reality. Exploring the fringe between fictional and virtual is one of the key goals, that will be achieved through etymologic and technologic definition of both fiction and virtual reality, fictional and virtual worlds. Both fiction and virtual reality will be then studied from aesthetic distance and aesthetic pleasure point of view. At the end, we will see the main difference as well as an common grounds between fiction and virtu...

Processed dairy beverages pH evaluation: consequences of temperature variation.

Science.gov (United States)

Ferreira, Fabiana Vargas; Pozzobon, Roselaine Terezinha

2009-01-01

This study assessed the pH from processed dairy beverages as well as eventual consequences deriving from different ingestion temperatures. 50 adults who accompanied children attended to at the Dentistry School were randomly selected and they answered a questionnaire on beverages. The beverages were divided into 4 groups: yogurt (GI) fermented milk (GII), chocolate-based products (GIII) and fermented dairy beverages (GIV). They were asked which type, flavor and temperature. The most popular beverages were selected, and these made up the sample. A pH meter Quimis 400A device was used to verify pH. The average pH from each beverage was calculated and submitted to statistical analysis (Variance and Tukey test with a 5% significance level). for groups I, II and III beverages, type x temperature interaction was significant, showing the pH averages were influenced by temperature variation. At iced temperatures, they presented lower pH values, which were considered statistically significant when compared to the values found for the same beverages at room temperature. All dairy beverages, with the exception of the chocolate-based type presented pH below critical level for enamel and present corrosive potential; as to ingestion temperature, iced temperature influenced pH reducing its values, in vitro.

Ex-plant consequence assessment for NUREG-1150: models, typical results, uncertainties

International Nuclear Information System (INIS)

Sprung, J.L.

1988-01-01

The assessment of ex-plant consequences for NUREG-1150 source terms was performed using the MELCOR Accident Consequence Code System (MACCS). This paper briefly discusses the following elements of MACCS consequence calculations: input data, phenomena modeled, computational framework, typical results, controlling phenomena, and uncertainties. Wherever possible, NUREG-1150 results will be used to illustrate the discussion. 28 references

The implication of using ''consequences'' as a criterion for reactor design

International Nuclear Information System (INIS)

Cave, L.; Holmes, P.

1978-01-01

The influences which may necessitate closer consideration of reactor accident consequences, rather than reactor risk, as a criterion for design are examined briefly. Possible methods for reducing consequences are described and the advantages of inherent features for this purpose are discussed. The cost effectiveness of two possible methods of reducing consequences and risks is estimated. (author)

Tank Bump Accident Potential and Consequences During Waste Retrieval

International Nuclear Information System (INIS)

BRATZEL, D.R.

2000-01-01

This report provides an evaluation of Hanford tank bump accident potential and consequences during waste retrieval operations. The purpose of this report is to consider the best available new information to support recommendations for safety controls. A new tank bump accident analysis for safe storage (Epstein et al. 2000) is extended for this purpose. A tank bump is a postulated event in which gases, consisting mostly of water vapor, are suddenly emitted from the waste and cause tank headspace pressurization. Tank bump scenarios, physical models, and frequency and consequence methods are fully described in Epstein et al. (2000). The analysis scope is waste retrieval from double-shell tanks (DSTs) including operation of equipment such as mixer pumps and air lift circulators. The analysis considers physical mechanisms for tank bump to formulate criteria for bump potential during retrieval, application of the criteria to the DSTs, evaluation of bump frequency, and consequence analysis of a bump. The result of the consequence analysis is the mass of waste released from tanks; radiological dose is calculated using standard methods (Cowley et al. 2000)

Anticipated affective consequences of physical activity adoption and maintenance.

Science.gov (United States)

Dunton, Genevieve Fridlund; Vaughan, Elaine

2008-11-01

The expected emotional consequences of future actions are thought to play an important role in health behavior change. This research examined whether anticipated affective consequences of success and failure vary across stages of physical activity change and differentially predict physical activity adoption as compared to maintenance. Using a prospective design over a 3-month period, a community sample of 329 healthy, middle-aged adults were assessed at 2 time points. Anticipated positive and negative emotions, stage of behavior change (precontemplation [PC], contemplation [C], preparation [P], action [A], maintenance [M]), and level of physical activity. At baseline, anticipated positive emotions were greater in C versus PC, whereas anticipated negative emotions were greater in M versus A and in M versus P. Higher anticipated positive but not negative emotions predicted physical activity adoption and maintenance after 3 months. Although the expected affective consequences of future success and failure differentiated among individuals in the early and later stages of physical activity change, respectively; only the anticipated affective consequences of success predicted future behavior.

Three consequences of the 2012 general elections

Directory of Open Access Journals (Sweden)

Daniel Buti

2013-04-01

Full Text Available The article represents an analysis of the 2012 general elections and their consequences on the Romanian political system. The variables analysed in the study are: the effective number of parties (N, the level of electoral disproportionality (G and the nature of bicameralism. Although measured indicators appear to call for an institutional approach and a formal analysis, the article tries to capture and simultaneously takes into account the functional dimension of the political system too. Thus, the consequences of the 2012 parliamentary elections reveal not necessarily the imbalance in the party system or the improvisation of a delegitimized electoral formula, but rather the current makeshift relationships between actors.

Galectins in angiogenesis: consequences for gestation.

Science.gov (United States)

Blois, Sandra M; Conrad, Melanie L; Freitag, Nancy; Barrientos, Gabriela

2015-04-01

Members of the galectin family have been shown to exert several roles in the context of reproduction. They contribute to placentation, maternal immune regulation and facilitate angiogenesis encompassing decidualisation and placenta formation during pregnancy. In the context of neo-vascularisation, galectins have been shown to augment signalling pathways that lead to endothelial cell activation, cell proliferation, migration and tube formation in vitro in addition to angiogenesis in vivo. Angiogenesis during gestation ensures not only proper foetal growth and development, but also maternal health. Consequently, restriction of placental blood flow has major consequences for both foetus and mother, leading to pregnancy diseases. In this review we summarise both the established and the emerging roles of galectin in angiogenesis and discuss the possible implications during healthy and pathological gestation. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

[Climate changes, floods, and health consequences].

Science.gov (United States)

Michelozzi, Paola; de' Donato, Francesca

2014-02-01

In the European Region, floods are the most common natural disaster, causing extensive damage and disruption. In Italy, it has been estimated that over 68% of municipalities are at high hydrogeological risk and with the recent intense rainfall events local populations have been facing severe disruptions. The health consequences of floods are wide ranging and are dependent upon the vulnerability of the environment and the local population. Health effects can be a direct or indirect consequence of flooding. The immediate health impacts of floods include drowning, heart attacks, injuries and hypothermia. The indirect effects include, injuries and infections, water-borne infectious disease, mental health problems, respiratory disease and allergies in both the medium and long term after a flood. Future efforts should be addressed to integrate health preparedness and prevention measures into emergency flood plans and hydrological warning systems.

The radiological assessment system for consequence analysis - RASCAL

International Nuclear Information System (INIS)

Sjoreen, A.L.; Ramsdell, J.V.; Athey, G.F.

1996-01-01

The Radiological Assessment System for Consequence Analysis, Version 2.1 (RASCAL 2.1) has been developed for use during a response to radiological emergencies. The model estimates doses for comparison with U.S. Environmental Protection Agency (EPA) Protective Action Guides (PAGs) and thresholds for acute health effects. RASCAL was designed to be used by U.S. Nuclear Regulatory Commission (NRC) personnel who report to the site of a nuclear accident to conduct an independent evaluation of dose and consequence projections and personnel who conduct training and drills on emergency responses. It allows consideration of the dominant aspects of the source term, transport, dose, and consequences. RASCAL consists of three computational tools: ST-DOSE, FM-DOSE, and DECAY. ST-DOSE computes source term, atmospheric transport, and dose to man from accidental airborne releases of radionuclides. The source-term calculations are appropriate for accidents at U.S. power reactors. FM-DOSE computes doses from environmental concentrations of radionuclides in the air and on the ground. DECAY computes radiological decay and daughter in-growth. RASCAL 2.1 is a DOS application that can be run under Windows 3.1 and 95. RASCAL has been the starting point for other accident consequence models, notably INTERRAS, an international version of RASCAL, and HASCAL, an expansion of RASCAL that will model radiological, biological, and chemical accidents

Estimating the effects of 17α-ethinylestradiol on stochastic population growth rate of fathead minnows: a population synthesis of empirically derived vital rates

Science.gov (United States)

Schwindt, Adam R.; Winkelman, Dana L.

2016-01-01

Urban freshwater streams in arid climates are wastewater effluent dominated ecosystems particularly impacted by bioactive chemicals including steroid estrogens that disrupt vertebrate reproduction. However, more understanding of the population and ecological consequences of exposure to wastewater effluent is needed. We used empirically derived vital rate estimates from a mesocosm study to develop a stochastic stage-structured population model and evaluated the effect of 17α-ethinylestradiol (EE2), the estrogen in human contraceptive pills, on fathead minnow Pimephales promelas stochastic population growth rate. Tested EE2 concentrations ranged from 3.2 to 10.9 ng L−1 and produced stochastic population growth rates (λ S ) below 1 at the lowest concentration, indicating potential for population decline. Declines in λ S compared to controls were evident in treatments that were lethal to adult males despite statistically insignificant effects on egg production and juvenile recruitment. In fact, results indicated that λ S was most sensitive to the survival of juveniles and female egg production. More broadly, our results document that population model results may differ even when empirically derived estimates of vital rates are similar among experimental treatments, and demonstrate how population models integrate and project the effects of stressors throughout the life cycle. Thus, stochastic population models can more effectively evaluate the ecological consequences of experimentally derived vital rates.

The Second Schleswig War 1864. Prelude, Events and Consequences

DEFF Research Database (Denmark)

Christensen, Jens Ole; Adriansen, Inge

The Second Schleswig War 1864 offers a reader-friendly overview of the prelude to the war, the events of the war itself, and its wide-ranging, long-lasting consequences.......The Second Schleswig War 1864 offers a reader-friendly overview of the prelude to the war, the events of the war itself, and its wide-ranging, long-lasting consequences....

Derivative chameleons

International Nuclear Information System (INIS)

Noller, Johannes

2012-01-01

We consider generalized chameleon models where the conformal coupling between matter and gravitational geometries is not only a function of the chameleon field φ, but also of its derivatives via higher order co-ordinate invariants (such as ∂ μ φ∂ μ φ,□φ,...). Specifically we consider the first such non-trivial conformal factor A(φ,∂ μ φ∂ μ φ). The associated phenomenology is investigated and we show that such theories have a new generic mass-altering mechanism, potentially assisting the generation of a sufficiently large chameleon mass in dense environments. The most general effective potential is derived for such derivative chameleon setups and explicit examples are given. Interestingly this points us to the existence of a purely derivative chameleon protected by a shift symmetry for φ → φ+c. We also discuss potential ghost-like instabilities associated with mass-lifting mechanisms and find another, mass-lowering and instability-free, branch of solutions. This suggests that, barring fine-tuning, stable derivative models are in fact typically anti-chameleons that suppress the field's mass in dense environments. Furthermore we investigate modifications to the thin-shell regime and prove a no-go theorem for chameleon effects in non-conformal geometries of the disformal type

Derivative chameleons

Energy Technology Data Exchange (ETDEWEB)

Noller, Johannes, E-mail: johannes.noller08@imperial.ac.uk [Theoretical Physics, Blackett Laboratory, Imperial College London, Prince Consort Road, London, SW7 2BZ (United Kingdom)

2012-07-01

We consider generalized chameleon models where the conformal coupling between matter and gravitational geometries is not only a function of the chameleon field φ, but also of its derivatives via higher order co-ordinate invariants (such as ∂{sub μ}φ∂{sup μ}φ,□φ,...). Specifically we consider the first such non-trivial conformal factor A(φ,∂{sub μ}φ∂{sup μ}φ). The associated phenomenology is investigated and we show that such theories have a new generic mass-altering mechanism, potentially assisting the generation of a sufficiently large chameleon mass in dense environments. The most general effective potential is derived for such derivative chameleon setups and explicit examples are given. Interestingly this points us to the existence of a purely derivative chameleon protected by a shift symmetry for φ → φ+c. We also discuss potential ghost-like instabilities associated with mass-lifting mechanisms and find another, mass-lowering and instability-free, branch of solutions. This suggests that, barring fine-tuning, stable derivative models are in fact typically anti-chameleons that suppress the field's mass in dense environments. Furthermore we investigate modifications to the thin-shell regime and prove a no-go theorem for chameleon effects in non-conformal geometries of the disformal type.

The derivation of a bistable criterion for double V-beam mechanisms

International Nuclear Information System (INIS)

Wu, Cho-Chun; Chen, Rongshun; Lin, Meng-Ju

2013-01-01

This study presents the theoretical derivation of the discriminant D as a structural and material criterion for determining whether bistability can occur in micromechanically bistable mechanisms. When D < 0, the mechanism displays bistable behavior if an appropriate force is applied to push the bistable mechanism, whereas when D > 0, bistable behavior cannot occur. The proposed V-beam bistable mechanism was successfully fabricated with various beam lengths and tilted angles. The experiments conducted in this study validated the theoretical study of bistability. A comparison of the theoretical solutions and experimental results shows good agreement. Results further show that to design a bistable V-beam mechanism, the tilted angle should be larger for the same beam length, whereas the beam length should be longer for the same tilted angle. The developed discriminant D can be used to predict if a bistable mechanism can achieve bistable behavior based on structural sizes and material properties. Consequently, researchers can reduce trial-and-error experiments when designing a bistable mechanism. A V-beam with a larger tilted angle of up to 5° was successfully fabricated to act as a bistable mechanism, compared to a 3.5° tilted angle in existing studies. Consequently, the proposed method has the advantages of shorter beam lengths and smaller device areas. (paper)

Consequence ranking of radionuclides in Hanford tank waste

International Nuclear Information System (INIS)

Schmittroth, F.A.; De Lorenzo, T.H.

1995-09-01

Radionuclides in the Hanford tank waste are ranked relative to their consequences for the Low-Level Tank Waste program. The ranking identifies key radionuclides where further study is merited. In addition to potential consequences for intrude and drinking-water scenarios supporting low-level waste activities, a ranking based on shielding criteria is provided. The radionuclide production inventories are based on a new and independent ORIGEN2 calculation representing the operation of all Hanford single-pass reactors and the N Reactor

Economic Consequence Analysis of Disasters: The ECAT Software Tool

Energy Technology Data Exchange (ETDEWEB)

Rose, Adam; Prager, Fynn; Chen, Zhenhua; Chatterjee, Samrat; Wei, Dan; Heatwole, Nathaniel; Warren, Eric

2017-04-15

This study develops a methodology for rapidly obtaining approximate estimates of the economic consequences from numerous natural, man-made and technological threats. This software tool is intended for use by various decision makers and analysts to obtain estimates rapidly. It is programmed in Excel and Visual Basic for Applications (VBA) to facilitate its use. This tool is called E-CAT (Economic Consequence Analysis Tool) and accounts for the cumulative direct and indirect impacts (including resilience and behavioral factors that significantly affect base estimates) on the U.S. economy. E-CAT is intended to be a major step toward advancing the current state of economic consequence analysis (ECA) and also contributing to and developing interest in further research into complex but rapid turnaround approaches. The essence of the methodology involves running numerous simulations in a computable general equilibrium (CGE) model for each threat, yielding synthetic data for the estimation of a single regression equation based on the identification of key explanatory variables (threat characteristics and background conditions). This transforms the results of a complex model, which is beyond the reach of most users, into a "reduced form" model that is readily comprehensible. Functionality has been built into E-CAT so that its users can switch various consequence categories on and off in order to create customized profiles of economic consequences of numerous risk events. E-CAT incorporates uncertainty on both the input and output side in the course of the analysis.

Antecedents and Consequences of Affective Commitment

NARCIS (Netherlands)

Bloemer, J.M.M.; Odekerken-Schröder, G.J.

2003-01-01

The primary objective of this study is to assess the impact of three psychological antecedents (position involvement, volitional choice and informational complexity) on affective commitment in a financial service setting. Furthermore, this study addresses the consequences of affective commitment on

Evaluation of methods to compare consequences from hazardous materials transportation accidents

International Nuclear Information System (INIS)

Rhoads, R.E.; Franklin, A.L.; Lavender, J.C.

1986-10-01

This report presents the results of a project to develop a framework for making meaningful comparisons of the consequences from transportation accidents involving hazardous materials. The project was conducted in two phases. In Phase I, methods that could potentially be used to develop the consequence comparisons for hazardous material transportation accidents were identified and reviewed. Potential improvements were identified and an evaluation of the improved methods was performed. Based on this evaluation, several methods were selected for detailed evaluation in Phase II of the project. The methods selected were location-dependent scenarios, figure of merit and risk assessment. This evaluation included application of the methods to a sample problem which compares the consequences of four representative hazardous materials - chlorine, propane, spent nuclear fuel and class A explosives. These materials were selected because they represented a broad class of hazardous material properties and consequence mechanisms. The sample case aplication relied extensively on consequence calculations performed in previous transportation risk assessment studies. A consultant was employed to assist in developing consequence models for explosives. The results of the detailed evaluation of the three consequence comparison methods indicates that methods are available to perform technically defensible comparisons of the consequences from a wide variety of hazardous materials. Location-dependent scenario and risk assessment methods are available now and the figure of merit method could be developed with additional effort. All of the methods require substantial effort to implement. Methods that would require substantially less effort were identified in the preliminary evaluation, but questions of technical accuracy preclude their application on a scale. These methods may have application to specific cases, however

Consequences of Illicit Trafficking of Nuclear or Other Radioactive Materials

International Nuclear Information System (INIS)

Moore, G.M.

2010-01-01

Explosion of a nuclear yield device is probably the worst consequence of Illicit Trafficking of nuclear or other radioactive materials.The nuclear yield device might be a stolen nuclear weapon, or an improvised nuclear device. An improvised nuclear device requires nuclear material design, and construction ability. Use of a radioactive dispersal device probably would not result in large numbers of casualties.However economic losses can be enormous. Non-Technical effects of nuclear trafficking (e.g. public panic, work disruption, etc.) and political and psychological consequences can far exceed technical consequences

Medical Student Attitudes Toward Older Patients: Predictors and Consequences

Science.gov (United States)

1989-12-18

DEC 1989 2. REPORT TYPE N/A 3. DATES COVERED - 4. TITLE AND SUBTITLE Medical Student Attitudes Toward Older Patients : Predictors and... MEDICAL CENTER . Title of Thesis: " Medical Student Attitudes Toward Older Patients : Predictors and Cons.equences" Name of Candidate: Victoria...dissertation manuscript entitled: 11 Medical Student Attitudes Toward Older Patients : Predictors and Consequences 11 beyond brief excerpts is with

VOLCANIC RISK ASSESSMENT - PROBABILITY AND CONSEQUENCES

International Nuclear Information System (INIS)

G.A. Valentine; F.V. Perry; S. Dartevelle

2005-01-01

Risk is the product of the probability and consequences of an event. Both of these must be based upon sound science that integrates field data, experiments, and modeling, but must also be useful to decision makers who likely do not understand all aspects of the underlying science. We review a decision framework used in many fields such as performance assessment for hazardous and/or radioactive waste disposal sites that can serve to guide the volcanological community towards integrated risk assessment. In this framework the underlying scientific understanding of processes that affect probability and consequences drive the decision-level results, but in turn these results can drive focused research in areas that cause the greatest level of uncertainty at the decision level. We review two examples of the determination of volcanic event probability: (1) probability of a new volcano forming at the proposed Yucca Mountain radioactive waste repository, and (2) probability that a subsurface repository in Japan would be affected by the nearby formation of a new stratovolcano. We also provide examples of work on consequences of explosive eruptions, within the framework mentioned above. These include field-based studies aimed at providing data for ''closure'' of wall rock erosion terms in a conduit flow model, predictions of dynamic pressure and other variables related to damage by pyroclastic flow into underground structures, and vulnerability criteria for structures subjected to conditions of explosive eruption. Process models (e.g., multiphase flow) are important for testing the validity or relative importance of possible scenarios in a volcanic risk assessment. We show how time-dependent multiphase modeling of explosive ''eruption'' of basaltic magma into an open tunnel (drift) at the Yucca Mountain repository provides insight into proposed scenarios that include the development of secondary pathways to the Earth's surface. Addressing volcanic risk within a decision

The Systematic Use of Positive and Negative Consequences in Managing Classroom Encopresis

Science.gov (United States)

George, Thomas W.; And Others

1977-01-01

This study reports a successful classroom intervention program which was designed to curb encopresis. It used positive consequences in combination with negative consequences, rather than negative consequences alone. Also it utilized a reversal strategy to evalulate the efficacy of the treatment variables. (Author)

Neurodevelopmental consequences of being born SGA

NARCIS (Netherlands)

van Wassenaer, Aleid

2005-01-01

Fetal growth retardation is associated with postnatal growth retardation and cardio-vascular and metabolic problems later on in life. Less well described are the consequences of neurodevelopmental outcome. The term SGA is associated with mild to moderate school problems, still present in late

Causes and consequences of adult sex ratio imbalance in a historical U.S. population.

Science.gov (United States)

Schacht, Ryan; Smith, Ken R

2017-09-19

The responsiveness of individuals to partner availability has been well-documented across the literature. However, there is disagreement regarding the direction of the consequences of sex ratio imbalance. Specifically, does an excess of males or females promote male-male mating competition? In an attempt to clarify the role of the adult sex ratio (ASR) on behaviour, here we evaluate both competing and complimentary expectations derived from theory across the social and biological sciences. We use data drawn from a historical, nineteenth century population in North America and target several life-history traits thought to be affected by partner availability: age at first birth, relationship status, completed fertility and longevity. Furthermore, we assess the role of various contributors to a population's ASR. We find that both the contributors to and consequences of sex ratio imbalance vary over time. Our results largely support predictions of greater male pairbond commitment and lesser male mating effort, as well as elevated bargaining power of women in response to female scarcity. After reviewing our findings, and others from across the literature, we highlight the need to adjust predictions in response to ASR imbalance by the: (i) culturally mediated mating arena, (ii) variable role of demographic inputs across time and place, (iii) constraints to behavioural outcomes across populations, and (iv) ability and accuracy of individuals to assess partner availability.This article is part of the themed issue 'Adult sex ratios and reproductive strategies: a critical re-examination of sex differences in human and animal societies'. © 2017 The Author(s).

Environmental consequences of alternatives to L Reactor restart

International Nuclear Information System (INIS)

1983-01-01

Alternatives to renewed L-Reactor operation for increased production of nuclear materials are: restart of R Reactor, construction and operation of a New Production Reactor (NPR), increased throughput of SRP reactors C, K, and P and N Reactor at Hanford, restart of K Reactors at Hanford, and no action - standby ready state for L Reactor. This report compares the environmental consequences from the proposed L-Reactor restart and these alternatives. The environmental consequences considered are radiological releases, radiocesium remobilization, nonradiological releases, ecological impacts and transportation

Consequences of a hypothetical incident for different sectors

CERN Document Server

Bertinelli, F; Garion, C; Jimenez, J M; Parma, V; Perin, A; Schmidt, R; Tavian, L; Tock, J P; van Weelderen, R

2011-01-01

During the 2009 long shutdown, the LHC machine has been partially consolidated by adding safety relief devices in order to better protect the cryostats against large helium release and consequently to mitigate the risks of collateral damages. After recalling the present relief valve implementation and other mitigations related to the collateral damages, this paper describes the damage process of a hypothetical incident, presents its consequences for the different sectors and for beam energies up to 5 TeV with emphasis on the induced downtime.

Chernobylsk accident (Causes and Consequences)-Part 1

International Nuclear Information System (INIS)

Esteves, D.

1986-07-01

Facts, project data, hypothesis, calculations, evaluations, monitoring, standard requirements and several considerations, related to causes, effects and consequences of Chernobylsk-4 accident. (M.C.K.) [pt

Influence of residual composition on the structure and properties of extracellular matrix derived hydrogels.

Science.gov (United States)

Claudio-Rizo, Jesús A; Rangel-Argote, Magdalena; Castellano, Laura E; Delgado, Jorge; Mata-Mata, José L; Mendoza-Novelo, Birzabith

2017-10-01

In this work, hydrolysates of extracellular matrix (hECM) were obtained from rat tail tendon (TR), bovine Achilles tendon (TAB), porcine small intestinal submucosa (SIS) and bovine pericardium (PB), and they were polymerized to generate ECM hydrogels. The composition of hECM was evaluated by quantifying the content of sulphated glycosaminoglycans (sGAG), fibronectin and laminin. The polymerization process, structure, physicochemical properties, in vitro degradation and biocompatibility were studied and related to their composition. The results indicated that the hECM derived from SIS and PB were significantly richer in sGAG, fibronectin and laminin, than those derived from TAB and TR. These differences in hECM composition influenced the polymerization and the structural characteristics of the fibrillar gel network. Consequently, the swelling, mechanics and degradation of the hydrogels showed a direct relationship with the remaining composition. Moreover, the cytocompatibility and the secretion of transforming growth factor beta-1 (TGF-β1) by macrophages were enhanced in hydrogels with the highest residual content of ECM biomolecules. The results of this work evidenced the role of the ECM molecules remaining after both decellularization and hydrolysis steps to produce tissue derived hydrogels with structure and properties tailored to enhance their performance in tissue engineering and regenerative medicine applications. Copyright © 2017 Elsevier B.V. All rights reserved.

CONSEQUENCES OF THE DEMOGRAPHIC CRISIS

Directory of Open Access Journals (Sweden)

LIVIU RADU

2014-11-01

Full Text Available Major dysfunctionalities can arise from the demographic decline, both on a social level and from the perspective of the economic-financial evolution of the world’s states. The obvious aging of the industrialized states’ population overlapping the import of cheap workforce in the developing countries can start mutations whose consequences are somewhat predictable but discouraging. An accelerated urbanization of the states is foreseen, as well as the decrease of birthrates, negative external migration, increase of mortality and its stagnation in a larger value than that of the birthrate, and not least the population’s aging will hinder a part of the developing countries to sustain a high rhythm of long-term economical increase. The socialeconomic consequences will be reflected in the labor market, the householders’ amount of income as well as in the education’s level. All of these aspects call for a rethinking of the public politics, especially of the social insurance’s system and of the education, a reorientation of the economy based on the increase of specializing in production and productivity, as well as a financial stability unburdened by the politics’ interference in the business environment.

Exploring Reasons and Consequences of Academic Procrastination: An Interview Study

Science.gov (United States)

Grunschel, Carola; Patrzek, Justine; Fries, Stefan

2013-01-01

In the present study, we broadly investigated reasons and consequences of academic procrastination. Additionally, we explored whether students seeking help from student counselling services to overcome academic procrastination (counselling group) report more serious reasons and consequences of academic procrastination than students who…

Prevention of the causes and consequences of a criticality accident - measures adopted in France; Prevention des causes et des consequences d'un accident de criticite - solutions adoptees en France

Energy Technology Data Exchange (ETDEWEB)

Fruchard, Y; Lavie, J M

1966-07-01

The question of safety in regard to criticality accident risks has two aspects: prevention of the cause and limitation of the consequences. These two aspects are closely connected. The effort devoted to prevention of the causes depends on the seriousness of the possible human psychologic and economic consequences of the accident. The criticality accidents which have occurred in the nuclear industry, though few in number, do reveal the imperfect nature of the techniques adopted to prevent the causes, and also constitute the only available realistic basis for evaluating the consequences and developing measures to limit them. The authors give a analysis of the known causes and consequences of past criticality accidents and on this basis make a number of comments concerning: the validity of traditional safety criteria, the probability of accidents for different types of operations, characteristic accidents which can serve as models, and the extent of possible radiological consequences. The measures adopted in France to limit the consequences of a possible criticality accident under the headings: location, design and lay-out of the installations, accident detection, and dosimetry for the exposed personnel, are briefly described after a short account of the criteria used in deciding on them. (author) [French] La surete relative aux risques d'accidents de criticite presente deux aspects: la prevention des causes et les parades aux consequences. Ces deux aspects sont tres lies. L'effort consenti a la prevention des causes decoule de l'importance des consequences humaines economiques et psychologiques possibles d'un eventuel accident. Les accidents de criticite survenus dans l'industrie nucleaire, malgre leur rarete, d'une part devoilent les imperfections des techniques de prevention des causes, d'autre part constituent la seule base realiste disponible d'evaluation des consequences et de mise au point des parades a ces consequences. Les auteurs presentent une analyse des

NNSA/NV Consequence Management Capabilities for Radiological Emergency Response

International Nuclear Information System (INIS)

Bowman, D. R.

2002-01-01

The U.S. Department of Energy's National Nuclear Security Administration Nevada Operations Office (NNSA/NV) provides an integrated Consequence Management (CM) response capability for the (NNSA) in the event of a radiological emergency. This encompasses planning, technical operations, and home team support. As the lead organization for CM planning and operations, NNSA/NV coordinates the response of the following assets during the planning and operational phases of a radiological accident or incident: (1) Predictive dispersion modeling through the Atmospheric Release Advisory Capability (ARAC) at Lawrence Livermore National Laboratory (LLNL) and the High Consequence Assessment Group at Sandia National Laboratories (SNL); (2) Regional radiological emergency assistance through the eight Radiological Assistance Program (RAP) regional response centers; (3) Medical advice and assistance through the Radiation Emergency Assistance Center/Training Site (REAC/TS) in Oak Ridge, Tennessee; (4) Aerial radiological mapping using the fixed-wing and rotor-wing aircraft of the Aerial Measuring System (AMS); (5) Consequence Management Planning Teams (CMPT) and Consequence Management Response Teams (CMRT) to provide CM field operations and command and control. Descriptions of the technical capabilities employed during planning and operations are given below for each of the elements comprising the integrated CM capability

Missed pills: frequency, reasons, consequences and solutions.

Science.gov (United States)

Chabbert-Buffet, Nathalie; Jamin, Christian; Lete, Iñaki; Lobo, Paloma; Nappi, Rossella E; Pintiaux, Axelle; Häusler, Günther; Fiala, Christian

2017-06-01

Oral hormonal contraception is an effective contraceptive method as long as regular daily intake is maintained. However, a daily routine is a constraint for many women and can lead to missed pills, pill discontinuation and/or unintended pregnancy. This article describes the frequency of inconsistent use, the consequences, the risk factors and the possible solutions. The article comprises a narrative review of the literature. Forgetting one to three pills per cycle is a frequent problem among 15-51% of users, generally adolescents. The reasons for this are age, inability to establish a routine, pill unavailability, side effects, loss of motivation and lack of involvement in the initial decision to use oral contraceptives. The consequences are 'escape ovulations' and, possibly, unintended pregnancy. Solutions are either to use a long-acting method or, for women who prefer to take oral contraceptives, use a continuous or long-cycle regimen to reduce the risks of follicular development and thus the likelihood of ovulation and unintended pregnancy. A progestogen with a long half-life can increase ovarian suppression. For women deciding to use oral contraceptives, a shortened or eliminated hormone-free interval and a progestogen with a long half-life may be an option to reduce the negative consequences of missed oral contraceptive pills.

Evaluation of nuclear accidents consequences. Risk assessment methodologies, current status and applications

International Nuclear Information System (INIS)

Rodriguez, J.M.

1996-01-01

General description of the structure and process of the probabilistic methods of assessment the external consequences in the event of nuclear accidents is presented. attention is paid in the interface with Probabilistic Safety Analysis level 3 results (source term evaluation) Also are described key issues in accident consequence evaluation as: effects evaluated (early and late health effects and economic effects due to countermeasures), presentation of accident consequences results, computer codes. Briefly are presented some relevant areas for the applications of Accident Consequence Evaluation

[Violence and health. Symptoms, consequences and treatment of victimized patients].

Science.gov (United States)

Habel, Ute; Wagels, Lisa; Ellendt, Sinika; Scheller, Maryse; Evler, Aynur; Bergs, René; Clemens, Benjamin; Pütz, Annette; Kohn, Nils; Schneider, Frank

2016-01-01

Violence has many faces and often results in a variety of consequences. Some studies indicated different types of violence and health consequences in men and women. However, it is still unclear whether this is reflected in clinical context, for example in a patient sample of a German university hospital. The primary goal of the present study was to analyze associations of violence with health, gender and social, economic, job-related, psychological and physical consequences. In addition, the effects of psychological treatment were examined. One line of research refers to the survey of more than 5000 patients of the university hospital Aachen, evaluating violence experience and several health complaints anonymously. Another line of research deals with detailed interviews with victims of violence and their experienced consequences. A final data source stems from the evaluation of psychological counseling of patients with prior experience of violence. Changes in subjectively perceived depressive symptoms and acceptance of the treatment are evaluated. Experience of violence increases the risk for several health problems, especially the experience of multiple types of violence. The interviews showed that more than 60% of the victims had a clinical diagnosis--independent of sex. The risk for a clinical diagnosis increased with multiple violence experiences during childhood. Patients with a clinical diagnosis indicated more subjective consequences of violence, and consequences of violence were more pronounced in patients that experienced multiple types of violence. The good acceptance as well as the effects on symptomatology and other relevant therapeutic variables provides a first indication for a successful treatment of victims of violence in a clinical context.

Application of the cause-consequence diagram method to static systems

International Nuclear Information System (INIS)

Andrews, J.D.; Ridley, L.M.

2002-01-01

In the last 30 years, various mathematical models have been used to identify the effect of component failures on the performance of a system. The most frequently used technique for system reliability assessment is Fault Tree Analysis (FTA) and a large proportion of its popularity can be attributed to the fact that it provides a very good documentation of the way that the system failure logic was developed. Exact quantification of the fault tree, however, can be problematic for very large systems and in such situations, approximations can be used. Alternatively, an exact result can be obtained via the conversion of the fault tree into a binary decision diagram (BDD). The BDD, however, loses all failure logic documentation during the conversion process. This paper outlines the use of the cause-consequence diagram method as a tool for system risk and reliability analysis. As with the FTA method, the cause-consequence diagram documents the failure logic of the system. In addition to this the cause-consequence diagram produces the exact failure probability in a very efficient calculation procedure. The cause-consequence diagram technique has been applied to a static system and shown to yield the same result as those produced by the solution of the equivalent fault tree and BDD. On the basis of this general rules have been devised for the correct construction of the cause-consequence diagram given a static system. The use of the cause-consequence method in this manner has significant implications in terms of efficiency of the reliability analysis and can be shown to have benefits for static systems

Application of capillary electrophoresis to the simultaneous determination and stability study of four extensively used penicillin derivatives

Directory of Open Access Journals (Sweden)

Brigitta Simon

2014-09-01

Full Text Available The applicability of capillary electrophoresis for the analysis of four extensively used penicillin derivatives (benzylpenicillin, ampicillin, amoxicillin, oxacilllin has been studied. Because of structural similarities, the electrophoretic behavior of these derivatives is very similar; consequently an efficient separation using the conventional capillary zone electrophoresis is hard to be achieved. Their simultaneous separation was solved by using micellar electrokinetic capillary chromatography, the separation being based on the differential partition of the analytes between the micellar and aqueous phase. Using a buffer solution containing 25 mM sodium tetraborate and 100 mM sodium dodecyl sulfate as surfactant, at a pH of 9.3, applying a voltage of + 25 kV at a temperature of 25 °C, we achieved the simultaneous separation of the studied penicillin derivatives in less then 5 minutes. The separation conditions were optimized and the analytical performance of the method was evaluated in terms of precision, linearity, limit of detection, and quantification. Also, a simple capillary zone electrophoresis method was applied to study the stability of the studied penicillin derivatives in water at different temperatures, using ciprofloxacin hydrochloride as internal standard. It was observed that the extent of the hydrolysis of penicillins in water is highly dependent on the time and also temperature.

Gravitational consequences of modern field theories

Science.gov (United States)

Horowitz, Gary T.

1989-01-01

Some gravitational consequences of certain extensions of Einstein's general theory of relativity are discussed. These theories are not alternative theories of gravity in the usual sense. It is assumed that general relativity is the appropriate description of all gravitational phenomena which were observed to date.

Tracking reason proof, consequence, and truth

CERN Document Server

Azzouni, Jody

2006-01-01

When ordinary people - mathematicians among them - take something to follow (deductively) from something else, they are exposing the backbone of our self-ascribed ability to reason. This book investigates the connection between that ordinary notion of consequence and the formal analogues invented by logicians.

The financial assurance of obliteration of mining activity consequences

OpenAIRE

Jaroslav Dvořáček

2004-01-01

The contribution deals with the financing of the obliteration of the mining activity consequences process which is considered as the general problem of mining industry connected with the mining activity completion. It deals with the existing law solution of this sphere in the Czech Republic and the changes expected. The procedures of the resources ensuring for the mining activity consequences obliteration used in abroad are mentioned here.

Real and mythical consequences of Chernobyl accident

International Nuclear Information System (INIS)

Osmachkin, V.S.

1999-01-01

This presentation describes the public Unacceptance of Nuclear Power as a consequence of Chernobyl Accident, an accident which was a severest event in the history of the nuclear industry. It was a shock for everybody, who has been involved in nuclear power programs. But nobody could expect that it was also the end romantic page in the nuclear story. The scale of the detriment was a great, and it could be compared with other big technological man-made catastrophes. But immediately after an accident mass media and news agencies started to transmit an information with a great exaggerations of the consequences of the event. In a report on the Seminar T he lessons of the Chernobyl - 1' in 1996 examples of such incorrect information, were cited. Particularly, in the mass media it was declared that consequences of the accident could be compared with a results of the second world war, the number of victims were more than hundred thousand people, more than million of children have the serious health detriments. Such and other cases of the misconstruction have been called as myths. The real consequences of Chernobyl disaster have been summed on the International Conference 'One decade after Chernobyl' - 2, in April 1996. A very important result of the Chernobyl accident was a dissemination of stable unacceptance of the everything connected with 'the atom'. A mystic horror from invisible mortal radiation has been inspired in the masses. And from such public attitude the Nuclear Power Programs in many countries have changed dramatically. A new more pragmatic and more careful atomic era started with a slogan: 'Kernkraftwerk ? Nein, danke'. No doubt, a Chernobyl accident was a serious technical catastrophe in atomic industry. The scale of detriment is connected with a number of involved peoples, not with a number of real victims. In comparison with Bhopal case, earthquakes, crashes of the airplanes, floods, traffic accidents and other risky events of our life - the Chernobyl is

Probabilistic consequence assessment of hydrogen sulphide releases from a heavy water plant

International Nuclear Information System (INIS)

Baynes, C.J.

1986-05-01

This report provides a summary of work carried out on behalf of the Atomic Energy Control Board, concerned with the consequences of accidental releases to the atmosphere of hydrogen sulphide (H 2 S) at a heavy water plant. In this study, assessments of consequences are made in terms of the probabilities of a range of possible outcomes, i.e., numbers of fatalities, given a certain release scenario. The report describes the major features of a computer model which was developed to calculate the consequences and their associated probabilities, and the major input data used in applying the model to a consequence assessment of the Bruce heavy water plant (HWP) in Ontario. The results of the sensitivity analyses of the model are summarized. Finally, the results of the consequence assessments of 43 accidental release scenarios at the Bruce HWP are summarized, together with a number of conclusions which were drawn from these results regarding the predicted consequences and the factors which influence them

Experts' understanding of partial derivatives using the Partial Derivative Machine

OpenAIRE

Roundy, David; Dorko, Allison; Dray, Tevian; Manogue, Corinne A.; Weber, Eric

2014-01-01

Partial derivatives are used in a variety of different ways within physics. Most notably, thermodynamics uses partial derivatives in ways that students often find confusing. As part of a collaboration with mathematics faculty, we are at the beginning of a study of the teaching of partial derivatives, a goal of better aligning the teaching of multivariable calculus with the needs of students in STEM disciplines. As a part of this project, we have performed a pilot study of expert understanding...

People, planet and profit: Unintended consequences of legacy building materials.

Science.gov (United States)

Zimmer, Anthony T; Ha, HakSoo

2017-12-15

Although an explosion of new building materials are being introduced into today's market, adequate up-front research into their chemical and physical properties as well as their potential health and environmental consequences is lacking. History has provided us with several examples where building materials were broadly deployed into society only to find that health and environmental problems resulted in unintended sustainability consequences. In the following paper, we use lead and asbestos as legacy building materials to show their similar historical trends and sustainability consequences. Our research findings show unintended consequences such as: increased remediation and litigation costs; adverse health effects; offshoring of related industries; and impediments to urban revitalization. As numerous new building materials enter today's market, another building material may have already been deployed, representing the next "asbestos." This paper also proposes an alternative methodology that can be applied in a cost-effective way into existing and upcoming building materials, to minimize and prevent potential unintended consequences and create a pathway for sustainable communities. For instance, our findings show that this proposed methodology could have prevented the unintended incurred sustainability costs of approximately $272-$359 billion by investing roughly $24 million in constant 2014 U.S. dollars on up-front research into lead and asbestos. Published by Elsevier Ltd.

Clinical consequences and economic costs of untreated obstructive sleep apnea syndrome

Directory of Open Access Journals (Sweden)

Melissa Knauert

2015-09-01

Full Text Available Objective: To provide an overview of the healthcare and societal consequences and costs of untreated obstructive sleep apnea syndrome. Data sources: PubMed database for English-language studies with no start date restrictions and with an end date of September 2014. Methods: A comprehensive literature review was performed to identify all studies that discussed the physiologic, clinical and societal consequences of obstructive sleep apnea syndrome as well as the costs associated with these consequences. There were 106 studies that formed the basis of this analysis. Conclusions: Undiagnosed and untreated obstructive sleep apnea syndrome can lead to abnormal physiology that can have serious implications including increased cardiovascular disease, stroke, metabolic disease, excessive daytime sleepiness, work-place errors, traffic accidents and death. These consequences result in significant economic burden. Both, the health and societal consequences and their costs can be decreased with identification and treatment of sleep apnea. Implications for practice: Treatment of obstructive sleep apnea syndrome, despite its consequences, is limited by lack of diagnosis, poor patient acceptance, lack of access to effective therapies, and lack of a variety of effective therapies. Newer modes of therapy that are effective, cost efficient and more accepted by patients need to be developed. Keywords: Obstructive sleep apnea syndrome, Cost, Continuous positive airway pressure, Mandibular advancement device

Atmospheric transport of urban-derived NHx: Evidence from nitrogen concentration and δ15N in epilithic mosses at Guiyang, SW China

International Nuclear Information System (INIS)

Liu Xueyan; Xiao Huayun; Liu Congqiang; Li Youyi; Xiao Hongwei

2008-01-01

Nitrogen concentration and δ 15 N in 175 epilithic moss samples were investigated along four directions from urban to rural sites in Guiyang, SW China. The spatial variations of moss N concentration and δ 15 N revealed that atmospheric N deposition is dominated by NH x -N from two major sources (urban sewage NH 3 and agricultural NH 3 ), the deposition of urban-derived NH x followed a point source pattern characterized by an exponential decline with distance from the urban center, while the agricultural-derived NH x was shown to be a non-point source. The relationship between moss N concentration and distance (y = 1.5e -0.13x + 1.26) indicated that the maximum transporting distance of urban-derived NH x averaged 41 km from the urban center, and it could be determined from the relationship between moss δ 15 N and distance [y = 2.54 ln(x) - 12.227] that urban-derived NH x was proportionally lower than agricultural-derived NH x in N deposition at sites beyond 17.2 km from the urban center. Consequently, the variation of urban-derived NH x with distance from the urban center could be modeled as y = 56.272e -0.116x - 0.481 in the Guiyang area. - Tissue N concentration and δ 15 N in epilithic mosses may be indicators for atmospheric transport of urban-derived NH x

The macroeconomic consequences of controlling greenhouse gases: a survey

International Nuclear Information System (INIS)

Boero, Gianna; Clarke, Rosemary; Winters, L.A.

1991-01-01

This is the summary of a major report which provides a survey of existing estimates of the macroeconomic consequences of controlling greenhouse gas emissions, particularly carbon dioxide (CO 2 ). There are broadly speaking two main questions. What are the consequences of global warming for economic activity and welfare? What, if any, are the economic consequences of reducing the levels of greenhouse gas (GHG) emissions? This survey covers only those studies which quantify the overall (macroeconomic) costs of abating greenhouse gas emissions. It is not concerned with whether any particular degree of abatement is sufficient to reduce global warming, nor whether it is worth undertaking in the light of its benefits. These are topics for other researchers and other papers. Here we are concerned only to map the relationship between economic welfare and GHG abatement. (author)

Logic TK: Algebraic Notions from Tarski’s Consequence Operator

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Hércules A. Feitosa

2010-01-01

Full Text Available Tarski apresentou sua definição de operador de consequência com a intenção de expor as concepções fundamentais da consequência lógica. Um espaço de Tarski é um par ordenado determinado por um conjunto não vazio e um operador de consequência sobre este conjunto. Esta estrutura matemática caracteriza um espaço quase topológico. Este artigo mostra uma visão algébrica dos espaços de Tarski e introduz uma lógica proposicional modal que interpreta o seu operador modal nos conjuntos fechados de algum espaço de Tarski.• DOI:10.5007/1808-1711.2010v14n1p47

Procrastination, consideration of future consequences, and episodic future thinking.

Science.gov (United States)

Rebetez, Marie My Lien; Barsics, Catherine; Rochat, Lucien; D'Argembeau, Arnaud; Van der Linden, Martial

2016-05-01

Despite the intrinsic temporal nature of procrastination, little research has examined the link between this form of self-regulatory failure and the consideration of future consequences, and no study has addressed the link between procrastination and episodic future thinking. The aim of the present study was to explore these relationships. Participants were asked to project themselves into possible future events and to rate the amount of sensory-perceptual details and autonoetic consciousness associated with their representations. They were also asked to complete questionnaires that assessed procrastination, the consideration of future consequences, and negative affect. Results showed that both the consideration of future consequences and episodic future thinking were associated with procrastination, and in particular with procrastination-related decision making abilities and procrastination-related motivational dispositions, respectively. Copyright © 2016 Elsevier Inc. All rights reserved.

Gender Matters: The Relationship between Social Anxiety and Alcohol-Related Consequences

OpenAIRE

Schry, Amie R.; Norberg, Melissa M.; Maddox, Brenna B.; White, Susan W.

2014-01-01

BACKGROUND AND OBJECTIVES: Identification of risk factors for alcohol-related consequences is an important public health concern. Both gender and social anxiety have been associated with alcohol-related consequences broadly, but it is unknown whether these variables are differentially related to specific types of alcohol-related consequences for American college students. METHODS: In the present study, 573 undergraduate students (M(age) = 19.86 years, SD = 1.40; range 18 to 25; 68.9% female) ...

Dysphagia in the patient after stroke: consequences and nurse intervention

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Ana Frias

2015-12-01

Full Text Available Objectives: to check the consequences of poststroke dysphagia and to reflect on the nurse’s intervention in dysphagia rehabilitation. Methodology: it was performed a systematic literature review of the topic in question; research based on international databases EBSCOhost, LILACS, SciELO.We were able to identify some studies publications between 2006 and 2014. We intend to answer the guiding question: What are the consequences of dysphagia in the patient after stroke? » Results vs. Discussion: after a thorough analysis, we have selected 11 articles and found that the most frequent consequences of dysphagia are the pulmonary complications by saliva and/or food suction. The nurse specialist still has a barely visible role, but his/her interventions are critical in these patients rehabilitation. Conclusions: rehabilitation is essential to avoid the consequences of poststroke dysphagia. The rehabilitation process must go through a multidisciplinary team of which nurses are an integral and essential part.

Research on Browsing Behavior in the Libraries: An Empirical Analysis of Consequences, Success and Influences

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Shan-Ju L. Chang

2000-12-01

Full Text Available Browsing as an important part of human information behavior has been observed and investigated in the context of information seeking in the library in general and has assumed greater importance in human-machine interaction in particular. However, the nature and consequences of browsing are not well understood, and little is known of the success rate of such behavior.In this research, exploratory empirical case studies from three types of libraries were conducted, using questionnaires, observation logs, interviews, and computer search logs, to derive the empirical evidence to understand, from the user point of view, what are the consequences of browsing, what constitutes successful browsing, and what factors influence the extent of browsing. Content analysis and statistical analysis were conducted to analyze and synthesize the data. The research results show: (1 There are nine categories of the consequence of browsing, including accidental findings, modification of information need, found the desirable information, learning, feeling relaxation/recreational, information gathering, keeping updated, satisfying curiosity, and not finding what is needed. (2 Four factors that produce successful browsing: intention, the amount or quality of information, the utility of what is found, and help for solving problem or making judgment. (3 Three types of reasons for unsuccessful experience in browsing: not finding what one wanted, inadequate volume or quality of information, and not finding some things useful or interesting. (4 Three types of reasons for partial success: found the intended object but not happy with the quality or amount of information in it, not finding what one wanted but discovering new or potential useful information, not accomplish one purpose but achieve another one given multiple purposes. (5 The influential factors that affect the extent one engages in browsing include browser’s time, scheme of information organization, proximity to

Feasibility of pig and human-derived aortic valve interstitial cells seeding on fixative-free decellularized animal pericardium.

Science.gov (United States)

Santoro, Rosaria; Consolo, Filippo; Spiccia, Marco; Piola, Marco; Kassem, Samer; Prandi, Francesca; Vinci, Maria Cristina; Forti, Elisa; Polvani, Gianluca; Fiore, Gianfranco Beniamino; Soncini, Monica; Pesce, Maurizio

2016-02-01

Glutaraldehyde-fixed pericardium of animal origin is the elective material for the fabrication of bio-prosthetic valves for surgical replacement of insufficient/stenotic cardiac valves. However, the pericardial tissue employed to this aim undergoes severe calcification due to chronic inflammation resulting from a non-complete immunological compatibility of the animal-derived pericardial tissue resulting from failure to remove animal-derived xeno-antigens. In the mid/long-term, this leads to structural deterioration, mechanical failure, and prosthesis leaflets rupture, with consequent need for re-intervention. In the search for novel procedures to maximize biological compatibility of the pericardial tissue into immunocompetent background, we have recently devised a procedure to decellularize the human pericardium as an alternative to fixation with aldehydes. In the present contribution, we used this procedure to derive sheets of decellularized pig pericardium. The decellularized tissue was first tested for the presence of 1,3 α-galactose (αGal), one of the main xenoantigens involved in prosthetic valve rejection, as well as for mechanical tensile behavior and distensibility, and finally seeded with pig- and human-derived aortic valve interstitial cells. We demonstrate that the decellularization procedure removed the αGAL antigen, maintained the mechanical characteristics of the native pig pericardium, and ensured an efficient surface colonization of the tissue by animal- and human-derived aortic valve interstitial cells. This establishes, for the first time, the feasibility of fixative-free pericardial tissue seeding with valve competent cells for derivation of tissue engineered heart valve leaflets. © 2015 Wiley Periodicals, Inc.

Global Derivatives Market

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Stankovska Aleksandra

2017-06-01

Full Text Available Globalization of financial markets led to the enormous growth of volume and diversification of financial transactions. Financial derivatives were the basic elements of this growth. Derivatives play a useful and important role in hedging and risk management, but they also pose several dangers to the stability of financial markets and thereby the overall economy. Derivatives are used to hedge and speculate the risk associated with commerce and finance.

High-precision atmospheric parameter and abundance determination of massive stars, and consequences for stellar and Galactic evolution

International Nuclear Information System (INIS)

Nieva, Maria-Fernanda; Przybilla, Norbert; Irrgang, Andreas

2011-01-01

The derivation of high precision/accuracy parameters and chemical abundances of massive stars is of utmost importance to the fields of stellar evolution and Galactic chemical evolution. We concentrate on the study of OB-type stars near the main sequence and their evolved progeny, the BA-type supergiants, covering masses of ∼6 to 25 solar masses and a range in effective temperature from ∼8000 to 35 000 K. The minimization of the main sources of systematic errors in the atmospheric model computation, the observed spectra and the quantitative spectral analysis play a critical role in the final results. Our self-consistent spectrum analysis technique employing a robust non-LTE line formation allows precise atmospheric parameters of massive stars to be derived, achieving 1σ-uncertainties as low as 1% in effective temperature and ∼0.05–0.10 dex in surface gravity. Consequences on the behaviour of the chemical elements carbon, nitrogen and oxygen are discussed here in the context of massive star evolution and Galactic chemical evolution, showing tight relations covered in previous work by too large statistical and systematic uncertainties. The spectral analysis of larger star samples, like from the upcoming Gaia-ESO survey, may benefit from these findings.

The consequences of the Chernobyl reactor accident

International Nuclear Information System (INIS)

Knoechel, A.

1988-01-01

After the decay of the iodine isotopes the measuring campaigns, in addition to the measuring of soil pollution and pollution of products, concentrated on the way of the cesium isotopes through the food chain, especially in crops, milk, meat and mother's milk. A special programme was developed for the analysis of foreign basic substances for teas, essences and tinctures. In connection with the incorporation measurements in the university hospital Eppendorf the measurement campaigns provided the data material in order to calculate with the aid of the computer program ECOSYS of the GSF the effective dose equivalent which the inhabitants of Hamburg additionally take up due to the accident of Chernobyl. Consequences with regard to measuring methods and social consequences are mentioned. (DG) [de

The Unequal Consequences of Mass Incarceration for Children.

Science.gov (United States)

Turney, Kristin

2017-02-01

A growing literature has documented the mostly deleterious intergenerational consequences of paternal incarceration, but less research has considered heterogeneity in these relationships. In this article, I use data from the Fragile Families and Child Wellbeing Study (N = 3,065) to estimate the heterogeneous relationship between paternal incarceration and children's problem behaviors (internalizing behaviors, externalizing behaviors, and early juvenile delinquency) and cognitive skills (reading comprehension, math comprehension, and verbal ability) in middle childhood. Taking into account children's risk of experiencing paternal incarceration, measured by the social contexts in which children are embedded (e.g., father's residential status, poverty, neighborhood disadvantage) reveals that the consequences-across all outcomes except early juvenile delinquency-are more deleterious for children with relatively low risks of exposure to paternal incarceration than for children with relatively high risks of exposure to paternal incarceration. These findings suggest that the intergenerational consequences of paternal incarceration are more complicated than documented in previous research and, more generally, suggest that research on family inequality consider both differential selection into treatments and differential responses to treatments.

US oil revolution: what strategic consequences?

International Nuclear Information System (INIS)

Tertrais, Bruno

2013-04-01

The US energy revolution will have profound and longstanding repercussions on its national economy and on the world market. What are the strategic consequences of this evolution? Some have suggested that US policy in the Middle East could undergo a deep transformation. Don't hold your breath. (author)

Mental illness stigma: concepts, consequences, and initiatives to reduce stigma.

Science.gov (United States)

Rüsch, Nicolas; Angermeyer, Matthias C; Corrigan, Patrick W

2005-12-01

Persons with mental illness frequently encounter public stigma and may suffer from self-stigma. This review aims to clarify the concept of mental illness stigma and discuss consequences for individuals with mental illness. After a conceptual overview of stigma we discuss two leading concepts of mental illness stigma and consequences of stigma, focussing on self-stigma/empowerment and fear of stigma as a barrier to using health services. Finally, we discuss three main strategies to reduce stigma -- protest, education, and contact -- and give examples of current anti-stigma campaigns. Well-designed anti-stigma initiatives will help to diminish negative consequences of mental illness stigma.

Design basis event consequence analyses for the Yucca Mountain project

International Nuclear Information System (INIS)

Orvis, D.D.; Haas, M.N.; Martin, J.H.

1997-01-01

Design basis event (DBE) definition and analysis is an ongoing and integrated activity among the design and analysis groups of the Yucca Mountain Project (YMP). DBE's are those that potentially lead to breach of the waste package and waste form (e.g., spent fuel rods) with consequent release of radionuclides to the environment. A Preliminary Hazards Analysis (PHA) provided a systematic screening of external and internal events that were candidate DBE's that will be subjected to analyses for radiological consequences. As preparation, pilot consequence analyses for the repository subsurface and surface facilities have been performed to define the methodology, data requirements, and applicable regulatory limits

Qualitative and quantitative assessment of the short- and long-term consequences of opting out of nuclear energy

International Nuclear Information System (INIS)

Briem, G.; Halstrick, M.; Heilemann, U.; Hillebrand, B.; Kiy, M.; Neuhaus, R.; Knieper, O.; Schmidt, H.W.; Weiss, T.

1986-08-01

A reference scenario establishes the prospective development of the energy and overall economy under status-quo conditions, i.e. assuming especially the continued use of nuclear energy, while two scenarios (alternative I: 'immediate opting out' and alternative II: 'opting out in the long term') try to assess the consequences of a shutdown of nuclear energy for the economic development of the Federal Republic of Germany. Especially, the study deals with the effects on the power industry, the ecological consequences, and the overall economic effects both in the short and long run. In all three scenarios, the development of the home consumption of electric power is first of all determined by a structure model of the entire economy. The capacity required to meet that demand and its use are calculated with the aid of a power plant model; short- and long-term cost-minimization programmes making allowance especially for fuel and capital costs from the elements from which these quantities are derived. Fuel and capital costs operate as variables in the structure model to determine the sectoral and overall economic development. The report in addition investigates separately, in partial models, the effects on the chemical industry and the branches of industry processing iron, steel, and non-ferrous metals, all of which are greatly in demand of electric power. (orig./UA) [de

Prevention of the causes and consequences of a criticality accident - measures adopted in France; Prevention des causes et des consequences d'un accident de criticite - solutions adoptees en France

Energy Technology Data Exchange (ETDEWEB)

Fruchard, Y.; Lavie, J.M

1966-07-01

The question of safety in regard to criticality accident risks has two aspects: prevention of the cause and limitation of the consequences. These two aspects are closely connected. The effort devoted to prevention of the causes depends on the seriousness of the possible human psychologic and economic consequences of the accident. The criticality accidents which have occurred in the nuclear industry, though few in number, do reveal the imperfect nature of the techniques adopted to prevent the causes, and also constitute the only available realistic basis for evaluating the consequences and developing measures to limit them. The authors give a analysis of the known causes and consequences of past criticality accidents and on this basis make a number of comments concerning: the validity of traditional safety criteria, the probability of accidents for different types of operations, characteristic accidents which can serve as models, and the extent of possible radiological consequences. The measures adopted in France to limit the consequences of a possible criticality accident under the headings: location, design and lay-out of the installations, accident detection, and dosimetry for the exposed personnel, are briefly described after a short account of the criteria used in deciding on them. (author) [French] La surete relative aux risques d'accidents de criticite presente deux aspects: la prevention des causes et les parades aux consequences. Ces deux aspects sont tres lies. L'effort consenti a la prevention des causes decoule de l'importance des consequences humaines economiques et psychologiques possibles d'un eventuel accident. Les accidents de criticite survenus dans l'industrie nucleaire, malgre leur rarete, d'une part devoilent les imperfections des techniques de prevention des causes, d'autre part constituent la seule base realiste disponible d'evaluation des consequences et de mise au point des parades a ces consequences

[The stigma of mental illness: concepts, forms, and consequences].

Science.gov (United States)

Rüsch, Nicolas; Angermeyer, Matthias C; Corrigan, Patrick W

2005-07-01

Persons with mental illness frequently encounter public stigma and may suffer from self-stigma. We aim to clarify the concept of mental illness stigma and discuss important consequences for people with mental illness. A search of scientific literature on mental illness stigma was conducted with a focus on conceptually relevant empirical studies. After giving a conceptual overview of stigma, we elaborate on the consequences of stigma, focussing on self-stigma/empowerment, coping behaviour, fear of stigma as a barrier to using health services, and on structural discrimination. Main strategies to reduce stigma -- protest, education, and contact -- are discussed. Stigma is of central importance to persons with mental illness, both to how they experience their illness and its consequences and whether they use available health services. Well-designed anti-stigma initiatives will help to diminish the impact of mental illness stigma.

Radiological terrorism: problems of prevention and minimization of consequences

International Nuclear Information System (INIS)

Bolshov, Leonid; Arutyunyan, Rafael; Pavlovski, Oleg

2008-01-01

This paper gives a review of the key factors defining the extent of potential hazard caused by ionizing radiation sources for the purpose of radiological terrorism and the key areas of activities in the field of counteractions and minimization of possible consequences of such acts. The importance of carrying out system analysis of the practical experience of response to radiation accidents and elimination of their consequences is emphasized. The need to develop scientific approaches, methods and software to realistically analyze possible scenarios and predict the scale of consequences of the acts of terrorism involving radioactive materials is pointed out. The importance of improvement of radioactive materials accounting, control and monitoring systems, especially in non-nuclear areas, as well as improvement of the legal and regulatory framework governing all aspects of radiation source application in the national economy is of particular importance. (author)

Activation of Cyclin-Dependent Kinase 5 Is a Consequence of Cell Death

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Yixia Ye

2009-01-01

Full Text Available Cyclin-dependent kinase 5 (Cdk5 is similar to other Cdks but is activated during cell differentiation and cell death rather than cell division. Since activation of Cdk5 has been reported in many situations leading to cell death, we attempted to determine if it was required for any form of cell death. We found that Cdk5 is activated during apoptotic deaths and that the activation can be detected even when the cells continue to secondary necrosis. This activation can occur in the absence of Bim, calpain, or neutral cathepsins. The kinase is typically activated by p25, derived from p35 by calpain-mediated cleavage, but inhibition of calpain does not affect cell death or the activation of Cdk5. Likewise, RNAi-forced suppression of the synthesis of Cdk5 does not affect the incidence or kinetics of cell death. We conclude that Cdk5 is activated as a consequence of metabolic changes that are common to many forms of cell death. Thus its activation suggests processes during cell death that will be interesting or important to understand, but activation of Cdk5 is not necessary for cells to die.

ANTECEDENTS AND CONSEQUENCES OF HOUSEHOLD FINANCIAL MANAGEMENT IN BRAZILIAN LOWER-MIDDLE-CLASS

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Ana Paula Miotto

2015-01-01

Full Text Available Through two complementary and exploratory studies – one qualitative and one quantitative – this research aims to understand the ways in which lower-middle-class families in Brazil manage their household finances. The study proposes an integrated framework that brings together various previously disconnected theoretical fragments. Based on a survey with a sample of 165 lower-middle-class female consumers of a retail company in São Paulo, we explored and tested, via a quantitative study, how antecedents such as personal characteristics affect the financial management process, as well as its consequences, either negatively as defaults or positively as savings. The model calibration and analysis were derived from a series of regression analyses. The results revealed the mediator role that financial management plays in the relationship between personal characteristics and defaults and savings. Compared to previous studies with consumers of more affluent countries, we identified peculiar findings among Brazilian lower-middle-class consumers: inadequate attention to control, weak or no focus on short- or long-range planning, widespread absence of budget surplus, and influence of critical events on episodes of default.

The modelling of economic consequences in COSYMA

International Nuclear Information System (INIS)

Faude, D.

1991-01-01

A new model for assessing the economic consequences of accidents, called COCO-1 (Cost of Consequences Off-site) has been developed jointly by NRPB and KfK under the CEC MARIA programme. This paper describes the way in which this model, together with other options, has been implemented in the ECONOMICS module of COSYMA. For consistency with the other parts of COSYMA, the coding of the ECONOMICS module is flexible: in several areas, alternative calculational methods are available and the user may select the method by which a particular cost is calculated. To some extent, economic models other than the COCO-1 model may be applied. There are two types of input data in the ECONOMICS module. These are (1) data from preceding COSYMA modules which quantify the magnitude and distribution of health effects and the impact of countermeasures, and (2) economic data, in terms of costs per unit quantity, to convert the preceding data into monetary values. The structure of the module has been determined by the form and availability of the input data, and the general structure of COSYMA. Details of the method of calculation, and the necessary input data, are discussed, for calculation of the economic consequences of the countermeasures considered in COSYMA (evacuation, relocation, sheltering, decontamination and food bans) and for early and late health effects

A bioengineered nisin derivative, M21A, in combination with food grade additives eradicates biofilms of Listeria monocytogenes.

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Lorraine Anne Draper

2016-11-01

Full Text Available The burden of foodborne disease has large economic and social consequences worldwide. Despite strict regulations, a number of pathogens persist within the food environment, which is greatly contributed to by a build-up of resistance mechanisms and also through the formation of biofilms. Biofilms have been shown to be highly resistant to a number of antimicrobials and can be extremely difficult to remove once they are established. In parallel, the growing concern of consumers regarding the use of chemically derived antimicrobials within food has led to a drive towards more natural products. As a consequence, the use of naturally derived antimicrobials has become of particular interest. In this study we investigated the efficacy of nisin A and its bioengineered derivative M21A in combination with food grade additives to treat biofilms of a representative strain of Listeria monocytogenes. Investigations revealed the enhanced antimicrobial effects, in liquid culture, of M21A in combination with citric acid or cinnamaldehyde over its wild type nisin A counterpart. Subsequently, an investigation was conducted into the effects of these combinations on an established biofilm of the same strain. Nisin M21A (0.1 µg/ml alone or in combination with cinnamaldehyde (35 µg/ml or citric acid (175 µg/ml performed significantly better than combinations involving nisin A. All combinations of M21A with either citric acid or cinnamaldehyde eradicated the L. monocytogenes biofilm (in relation to a non-biofilm control. We conclude that M21A in combination with available food additives could further enhance the antimicrobial treatment of biofilms within the food industry, simply by substituting nisin A with M21A in current commercial products such as Nisaplin (Danisco, DuPont.

Individual Consequences of Internal Marketing

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Naghi Remus Ionut

2015-07-01

Full Text Available Since the emergence of the concept of internal marketing in the literature there have been almost 40 years. This period was marked by a constant increase of the concerns in the internal marketing area, these efforts being evidenced by the publication of a consistent number of articles (conceptual and empirical which analyze this subject. Considering the previous empirical studies, most of them have focused on studying the relationship between internal marketing and employee satisfaction and / or organizational commitment. However, the relationship between internal marketing and its consequences has been less analyzed in the context of emergent economies. In this paper we aimed to analyze the individual consequences of the internal marketing in the Romanian economy context, focusing our attention on three constructs: employee satisfaction, organizational commitment and organizational citizenship behavior. The research was conducted on a sample of 83 medium and large companies in various sectors of the Romanian economy. In order to proceed with the statistical data analyses we followed these steps: verifying the scales reliability, determining factor loadings and research hypotheses testing. Our research results are consistent with results of previous studies showing that the adoption of internal marketing practice has a positive effect on employee satisfaction, organizational commitment and organizational citizenship behavior

Reports of unintended consequences of financial incentives to improve management of hypertension.

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Sylvia J Hysong

Full Text Available Given the increase in financial-incentive programs nationwide, many physicians and physician groups are concerned about potential unintended consequences of providing financial incentives to improve quality of care. However, few studies examine whether actual unintended consequences result from providing financial incentives to physicians. We sought to document the extent to which the unintended consequences discussed in the literature were observable in a randomized clinical trial (RCT of financial incentives.We conducted a qualitative observational study nested within a larger RCT of financial incentives to improve hypertension care. We conducted 30-minute telephone interviews with primary care personnel at facilities participating in the RCT housed at12 geographically dispersed Veterans Affairs Medical Centers nationwide. Participants answered questions about unintended effects, clinic team dynamics, organizational impact on care delivery, study participation. We employed a blend of inductive and deductive qualitative techniques for analysis.Sixty-five participants were recruited from RCT enrollees and personnel not enrolled in the larger RCT, plus one primary care leader per site.Emergent themes included possible patient harm, emphasis on documentation over improving care, reduced professional morale, and positive spillover. All discussions of unintended consequences involving patient harm were only concerns, not actual events. Several unintended consequences concerned ancillary initiatives for quality improvement (e.g., practice guidelines and performance measurement systems rather than financial incentives.Many unintended consequences of financial incentives noted were either only concerns or attributable to ancillary quality-improvement initiatives. Actual unintended consequences included improved documentation of care without necessarily improving actual care, and positive unintended consequences.Clinicaltrials.gov Identifier: NCT

Psychosocial consequences of allocation to lung cancer screening: a randomised controlled trial.

Science.gov (United States)

Aggestrup, Louise Mosborg; Hestbech, Mie Sara; Siersma, Volkert; Pedersen, Jesper Holst; Brodersen, John

2012-01-01

To examine the psychosocial consequences of being allocated to the control group as compared with the screen group in a randomised lung cancer screening trial. The Danish Lung Cancer Screening Trial, a randomised controlled trial, ran from 2004 to 2010 with the purpose of investigating the benefits and harms of lung cancer screening. The participants in Danish Lung Cancer Screening Trial were randomised to either the control group or the screen group and were asked to complete the questionnaires Consequences Of Screening and Consequences Of Screening in Lung Cancer (COS-LC). The Consequences Of Screening and the COS-LC were used to examine the psychosocial consequences of participating in the study, by comparing the control and the screen groups' responses at the prevalence and at the incidence round. There was no statistically significant difference in socio-demographic characteristics or smoking habits between the two groups. Responses to the COS-LC collected before the incidence round were statistically significantly different on the scales 'anxiety', 'behaviour', 'dejection', 'self-blame', 'focus on airway symptoms' and 'introvert', with the control group reporting higher negative psychosocial consequences. Furthermore, the participants in both the control and the screen groups exhibited a mean increase in negative psychosocial consequences when their responses from the prevalence round were compared with their responses from the first incidence round. Participation in a randomised controlled trial on lung cancer screening has negative psychosocial consequences for the apparently healthy participants-both the participants in the screen group and the control group. This negative impact was greatest for the control group.

CONSEQUENCES OF EMPLOYEE’S CUSTOMER ORIENTATION IN PUBLIC SERVICES

OpenAIRE

Andrada IACOB

2015-01-01

The goal of this paper is to explore the consequences of employee’s customer orientation in public services organizations. We will start with a literature review of the theory of customer orientation measurement and the consequences of this orientation at organizational and individual level. Then, the research methodology and results are presented. Conclusions, research limitations and future directions are included at the end of the paper. We identified positive direct effects of the employe...

An alternative derivation of the Dirac operator generating intrinsic Lagrangian local gauge invariance

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Brian Jonathan Wolk

2017-01-01

Full Text Available This paper introduces an alternative formalism for deriving the Dirac operator and equation. The use of this formalism concomitantly generates a separate operator coupled to the Dirac operator. When operating on a Clifford field, this coupled operator produces field components which are formally equivalent to the field components of Maxwell's electromagnetic field tensor. Consequently, the Lagrangian of the associated coupled field exhibits internal local gauge symmetry. The coupled field Lagrangian is seen to be equivalent to the Lagrangian of Quantum Electrodynamics. Received: 8 November 2016, Accepted: 4 January 2017; Edited by: D. Gomez Dumm; DOI: http://dx.doi.org/10.4279/PIP.090002 Cite as: B J Wolk, Papers in Physics 9, 090002 (2017

Paternal Alcoholism: Consequences for Female Children

Science.gov (United States)

Dehn, Julia

2010-01-01

The consequences of substance abuse and addiction are profound and depredating. The desolation is incalculable in estimating the psychological damage and trauma inflicted on the children of addicted parents. According to studies and statistics gathered by the National Association for Children of Alcoholics, "there are more than 20 million children…

Consequences of hadron-nucleus multiplicity parametrization

International Nuclear Information System (INIS)

Singh, C.P.; Shyam, M.

1986-01-01

Some interesting consequences are analyzed of a new parametrization for the hadron-nucleus multiplicity distributions and they are compared with the experimental data. Further, it is illustrated how the scaling property for the average multiplicity will be modified and it is found that the experimental data support this behaviour. (orig.)

The Influence of Environmental Consequences and Internalizing Symptoms on Children's Tic Severity.

Science.gov (United States)

Eaton, Cyd K; Jones, Anna M; Gutierrez-Colina, Ana M; Ivey, Emily K; Carlson, Olivia; Melville, Lauren; Kardon, Patricia; Blount, Ronald L

2017-04-01

Although there is evidence that environmental consequences for displaying tics and internalizing symptoms are related to tic severity in children with TS, less is known about the inter-relationships of these variables or how these factors jointly contribute to tic severity. This study included 45 children with Tourette syndrome. Caregivers reported on children's environmental consequences for displaying tics, internalizing symptoms, and tic severity. Results indicated that children with higher levels of internalizing symptoms experienced significantly more environmental consequences for displaying tics. Children with higher levels of separation anxiety symptoms demonstrated significantly greater tic severity. Environmental consequences for displaying tics accounted for significantly more variance in predicting tic severity than anxiety symptoms. This preliminary evidence suggests that environmental consequences for displaying tics, such as receiving accommodations or attention from others, have a greater influence on children's tic severity than emotional factors.

Exosomes derived from human umbilical cord blood mesenchymal stem cells stimulates rejuvenation of human skin.

Science.gov (United States)

Kim, Yoon-Jin; Yoo, Sae Mi; Park, Hwan Hee; Lim, Hye Jin; Kim, Yu-Lee; Lee, Seunghee; Seo, Kwang-Won; Kang, Kyung-Sun

2017-11-18

Human umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs) play an important role in cutaneous wound healing, and recent studies suggested that MSC-derived exosomes activate several signaling pathways, which are conducive in wound healing and cell growth. In this study, we investigated the roles of exosomes that are derived from USC-CM (USC-CM Exos) in cutaneous collagen synthesis and permeation. We found that USC-CM has various growth factors associated with skin rejuvenation. Our in vitro results showed that USC-CM Exos integrate in Human Dermal Fibroblasts (HDFs) and consequently promote cell migration and collagen synthesis of HDFs. Moreover, we evaluated skin permeation of USC-CM Exos by using human skin tissues. Results showed that Exo-Green labeled USC-CM Exos approached the outermost layer of the epidermis after 3 h and gradually approached the epidermis after 18 h. Moreover, increased expressions of Collagen I and Elastin were found after 3 days of treatment on human skin. The results showed that USC-CM Exos is absorbed into human skin, it promotes Collagen I and Elastin synthesis in the skin, which are essential to skin rejuvenation and shows the potential of USC-CM integration with the cosmetics or therapeutics. Copyright © 2017 Elsevier Inc. All rights reserved.

Derivatives in emerging markets

OpenAIRE

Dubravko Mihaljek; Frank Packer

2010-01-01

Turnover of derivatives has grown more rapidly in emerging markets than in developed countries. Foreign exchange derivatives are the most commonly traded of all risk categories, with increasingly frequent turnover in emerging market currencies and a growing share of cross-border transactions. As the global reach of the financial centres in emerging Asia has expanded, the offshore trading of many emerging market currency derivatives has risen as well. Growth in derivatives turnover is positive...

Evolutionary impact assessment: accounting for evolutionary consequences of fishing in an ecosystem approach to fisheries management.

Science.gov (United States)

Laugen, Ane T; Engelhard, Georg H; Whitlock, Rebecca; Arlinghaus, Robert; Dankel, Dorothy J; Dunlop, Erin S; Eikeset, Anne M; Enberg, Katja; Jørgensen, Christian; Matsumura, Shuichi; Nusslé, Sébastien; Urbach, Davnah; Baulier, Loїc; Boukal, David S; Ernande, Bruno; Johnston, Fiona D; Mollet, Fabian; Pardoe, Heidi; Therkildsen, Nina O; Uusi-Heikkilä, Silva; Vainikka, Anssi; Heino, Mikko; Rijnsdorp, Adriaan D; Dieckmann, Ulf

2014-03-01

Managing fisheries resources to maintain healthy ecosystems is one of the main goals of the ecosystem approach to fisheries (EAF). While a number of international treaties call for the implementation of EAF, there are still gaps in the underlying methodology. One aspect that has received substantial scientific attention recently is fisheries-induced evolution (FIE). Increasing evidence indicates that intensive fishing has the potential to exert strong directional selection on life-history traits, behaviour, physiology, and morphology of exploited fish. Of particular concern is that reversing evolutionary responses to fishing can be much more difficult than reversing demographic or phenotypically plastic responses. Furthermore, like climate change, multiple agents cause FIE, with effects accumulating over time. Consequently, FIE may alter the utility derived from fish stocks, which in turn can modify the monetary value living aquatic resources provide to society. Quantifying and predicting the evolutionary effects of fishing is therefore important for both ecological and economic reasons. An important reason this is not happening is the lack of an appropriate assessment framework. We therefore describe the evolutionary impact assessment (EvoIA) as a structured approach for assessing the evolutionary consequences of fishing and evaluating the predicted evolutionary outcomes of alternative management options. EvoIA can contribute to EAF by clarifying how evolution may alter stock properties and ecological relations, support the precautionary approach to fisheries management by addressing a previously overlooked source of uncertainty and risk, and thus contribute to sustainable fisheries.

Towards the Fecal Metabolome Derived from Moderate Red Wine Intake

Directory of Open Access Journals (Sweden)

Ana Jiménez-Girón

2014-12-01

Full Text Available Dietary polyphenols, including red wine phenolic compounds, are extensively metabolized during their passage through the gastrointestinal tract; and their biological effects at the gut level (i.e., anti-inflammatory activity, microbiota modulation, interaction with cells, among others seem to be due more to their microbial-derived metabolites rather than to the original forms found in food. In an effort to improve our understanding of the biological effects that phenolic compounds exert at the gut level, this paper summarizes the changes observed in the human fecal metabolome after an intervention study consisting of a daily consumption of 250 mL of wine during four weeks by healthy volunteers (n = 33. It assembles data from two analytical approaches: (1 UPLC-ESI-MS/MS analysis of phenolic metabolites in fecal solutions (targeted analysis; and (2 UHPLC-TOF MS analysis of the fecal solutions (non-targeted analysis. Both approaches revealed statistically-significant changes in the concentration of several metabolites as a consequence of the wine intake. Similarity and complementarity between targeted and non-targeted approaches in the analysis of the fecal metabolome are discussed. Both strategies allowed the definition of a complex metabolic profile derived from wine intake. Likewise, the identification of endogenous markers could lead to new hypotheses to unravel the relationship between moderate wine consumption and the metabolic functionality of gut microbiota.

fq-Derivations of G-Algebra

Directory of Open Access Journals (Sweden)

Deena Al-Kadi

2016-01-01

Full Text Available We introduce the notion of fq-derivation as a new derivation of G-algebra. For an endomorphism map f of any G-algebra X, we show that at least one fq-derivation of X exists. Moreover, for such a map, we show that a self-map dqf of X is fq-derivation of X if X is an associative medial G-algebra. For a medial G-algebra X, dqf is fq-derivation of X if dqf is an outside fq-derivation of X. Finally, we show that if f is the identity endomorphism of X then the composition of two fq-derivations of X is a fq-derivation. Moreover, we give a condition to get a commutative composition.

Electricity derivatives

CERN Document Server

Aïd, René

2015-01-01

Offering a concise but complete survey of the common features of the microstructure of electricity markets, this book describes the state of the art in the different proposed electricity price models for pricing derivatives and in the numerical methods used to price and hedge the most prominent derivatives in electricity markets, namely power plants and swings. The mathematical content of the book has intentionally been made light in order to concentrate on the main subject matter, avoiding fastidious computations. Wherever possible, the models are illustrated by diagrams. The book should allow prospective researchers in the field of electricity derivatives to focus on the actual difficulties associated with the subject. It should also offer a brief but exhaustive overview of the latest techniques used by financial engineers in energy utilities and energy trading desks.

Youth Unemployment. The Causes and Consequences.

Science.gov (United States)

Organisation for Economic Cooperation and Development, Paris (France).

This report examines the causes and consequences of youth unemployment in Organisation for Economic Cooperation and Development (OECD) member countries. Summarized first is the youth unemployment situation since the 1974/1975 recession. In a section on recent developments in youth labor markets a series of tables and graphs provide data on youth…

Pharmacovigilance: the devastating consequences of not thinking ...

African Journals Online (AJOL)

Pharmacovigilance: the devastating consequences of not thinking about adverse drug reactions: The burden of adverse drug reactions (ADRs) on patient care has been found to be high globally and is particularly high in South Africa.

Long-term Consequences of Childhood ADHD on Criminal Activities*

OpenAIRE

Fletcher, Jason; Wolfe, Barbara

2009-01-01

The question of whether childhood mental illness has long term consequences in terms of criminal behavior has been little studied, yet it could have major consequences for both the individual and society more generally. In this paper, we focus on Attention-Deficit/Hyperactivity Disorder (ADHD), one of the most prevalent mental conditions in school-age children, to examine the long-term effects of childhood mental illness on criminal activities, controlling for a rich set of individual, family...

The Czech Equity Market - Its Effectiveness and Macroeconomic Consequences

OpenAIRE

Helena Horská

2005-01-01

This paper examines features of the Czech stock market’s development from 1997 to 2003 and attempts to unveil the macroeconomic consequences of stock-price development. The analysis of the stock market’s behavior supports a cautionary stance on the hypothesis of the efficient-market theory, even in its weak form. Another finding, as regards the macroeconomic consequences of stock-price development, undermined the assumption of the positive wealth effect of rising stocks. In relation to GDP gr...

Source term and radiological consequences of the Chernobyl accident

International Nuclear Information System (INIS)

Mourad, R.

1987-09-01

This report presents the results of a study of the source term and radiological consequences of the Chernobyl accident. The results two parts. The first part was performed during the first 2 months following the accident and dealt with the evaluation of the source term and an estimate of individual doses in the European countries outside the Soviet Union. The second part was performed after August 25-29, 1986 when the Soviets presented in a IAEA Conference in Vienna detailed information about the accident, including source term and radiological consequences in the Soviet Union. The second part of the study reconfirms the source term evaluated in the first part and in addition deals with the radiological consequences in the Soviet Union. Source term and individual doses are calculated from measured post-accident data, reported by the Soviet Union and European countries, microcomputer program PEAR (Public Exposure from Accident Releases). 22 refs

Crises communication practices and their consequences for risk communication

DEFF Research Database (Denmark)

Andersen, Nina Blom

Title of paper: Crisis communication practices and their consequences for risk communication   There is a close coverage of disasters in modern western societies in the media. And there is a growing expectation that authorities handle the tasks of crisis communication in certain ways.   The first...... aim of this paper is to show, that the communication practices about the consequences of a disaster tend to focus on the individual citizen’s situation, and include the psychological consequences and suffering to a large degree. At least for a while. Then the debates and discussions about the event...... change from concern and care about the people affected towards discussions about e.g. cause, responsibility or even guilt.   The second aim of the paper is to discuss other ways for a society to come to terms with risks that leads to disastrous situations than through the topics mentioned above...

Crises communication practices and their consequences for risk communication

DEFF Research Database (Denmark)

Andersen, Nina Blom

2016-01-01

Title of paper: Crisis communication practices and their consequences for risk communication There is a close coverage of disasters in modern western societies in the media. And there is a growing expectation that authorities handle the tasks of crisis communication in certain ways. The first aim...... of this paper is to show, that the communication practices about the consequences of a disaster tend to focus on the individual citizen?s situation, and include the psychological consequences and suffering to a large degree. At least for a while. Then the debates and discussions about the event change from...... concern and care about the people affected towards discussions about e.g. cause, responsibility or even guilt. The second aim of the paper is to discuss other ways for a society to come to terms with risks that leads to disastrous situations than through the topics mentioned above, and as well how...

Short- and long-term health consequences of sleep disruption.

Science.gov (United States)

Medic, Goran; Wille, Micheline; Hemels, Michiel Eh

2017-01-01

Sleep plays a vital role in brain function and systemic physiology across many body systems. Problems with sleep are widely prevalent and include deficits in quantity and quality of sleep; sleep problems that impact the continuity of sleep are collectively referred to as sleep disruptions. Numerous factors contribute to sleep disruption, ranging from lifestyle and environmental factors to sleep disorders and other medical conditions. Sleep disruptions have substantial adverse short- and long-term health consequences. A literature search was conducted to provide a nonsystematic review of these health consequences (this review was designed to be nonsystematic to better focus on the topics of interest due to the myriad parameters affected by sleep). Sleep disruption is associated with increased activity of the sympathetic nervous system and hypothalamic-pituitary-adrenal axis, metabolic effects, changes in circadian rhythms, and proinflammatory responses. In otherwise healthy adults, short-term consequences of sleep disruption include increased stress responsivity, somatic pain, reduced quality of life, emotional distress and mood disorders, and cognitive, memory, and performance deficits. For adolescents, psychosocial health, school performance, and risk-taking behaviors are impacted by sleep disruption. Behavioral problems and cognitive functioning are associated with sleep disruption in children. Long-term consequences of sleep disruption in otherwise healthy individuals include hypertension, dyslipidemia, cardiovascular disease, weight-related issues, metabolic syndrome, type 2 diabetes mellitus, and colorectal cancer. All-cause mortality is also increased in men with sleep disturbances. For those with underlying medical conditions, sleep disruption may diminish the health-related quality of life of children and adolescents and may worsen the severity of common gastrointestinal disorders. As a result of the potential consequences of sleep disruption, health care

SYNTHESIS OF FLAVANONE-6-CARBOXYLIC ACID DERIVATIVES FROM SALICYLIC ACID DERIVATIVE

Directory of Open Access Journals (Sweden)

Muhammad Idham Darussalam Mardjan

2012-02-01

Full Text Available Synthesis of flavanone-6-carboxylic acid derivatives had been conducted via the route of chalcone. The synthesis was carried out from salicylic acid derivative, i.e. 4-hydroxybenzoic acid, via esterification, Fries rearrangement, Claisen-Schmidt condensation and 1,4-nucleophilic addition reactions. Structure elucidation of products was performed using FT-IR, 1H-NMR, GC-MS and UV-Vis spectrometers. Reaction of 4-hydroxybenzoic acid with methanol catalyzed with sulfuric acid produced methyl 4-hydroxybenzoate in 87% yield. The acid-catalyzed-acetylation of the product using acetic anhydride gave methyl 4-acetoxybenzoate in 75% yield. Furthermore, solvent-free Fries rearrangement of methyl 4-acetoxybenzoate in the presence of AlCl3 produced 3-acetyl-4-hydroxybenzoic acid as the acetophenone derivatives in 67% yield. Then, Claisen-Schmidt condensation of the acetophenone and benzaldehyde derivatives of p-anisaldehyde and veratraldehyde in basic condition gave 2'-hydroxychalcone-5'-carboxylic acid derivatives  in 81 and 71 % yield, respectively. Finally, the ring closure reaction of the chalcone yielded the corresponding flavanone-6-carboxylic acids in 67 and 59% yield, respectively.

Toxic release consequence analysis tool (TORCAT) for inherently safer design plant

International Nuclear Information System (INIS)

Shariff, Azmi Mohd; Zaini, Dzulkarnain

2010-01-01

Many major accidents due to toxic release in the past have caused many fatalities such as the tragedy of MIC release in Bhopal, India (1984). One of the approaches is to use inherently safer design technique that utilizes inherent safety principle to eliminate or minimize accidents rather than to control the hazard. This technique is best implemented in preliminary design stage where the consequence of toxic release can be evaluated and necessary design improvements can be implemented to eliminate or minimize the accidents to as low as reasonably practicable (ALARP) without resorting to costly protective system. However, currently there is no commercial tool available that has such capability. This paper reports on the preliminary findings on the development of a prototype tool for consequence analysis and design improvement via inherent safety principle by utilizing an integrated process design simulator with toxic release consequence analysis model. The consequence analysis based on the worst-case scenarios during process flowsheeting stage were conducted as case studies. The preliminary finding shows that toxic release consequences analysis tool (TORCAT) has capability to eliminate or minimize the potential toxic release accidents by adopting the inherent safety principle early in preliminary design stage.

Effect of the structure of gallic acid and its derivatives on their interaction with plant ferritin.

Science.gov (United States)

Wang, Qunqun; Zhou, Kai; Ning, Yong; Zhao, Guanghua

2016-12-15

Gallic acid and its derivatives co-exist with protein components in foodstuffs, but there is few report on their interaction with proteins. On the other hand, plant ferritin represents not only a novel class of iron supplement, but also a new nanocarrier for encapsulation of bioactive nutrients. However, plant ferritin is easy to be degraded by pepsin in the stomach, thereby limiting its application. Herein, we investigated the interaction of gallic acid and its derivatives with recombinant soybean seed H-2 ferritin (rH-2). We found that these phenolic acids interacted with rH-2 in a structure-dependent manner; namely, gallic acid (GA), methyl gallate (MEGA) and propyl gallate (PG) having three HO groups can bind to rH-2, while their analogues with two HO groups cannot. Consequently, such binding largely inhibited ferritin degradation by pepsin. These findings advance our understanding of the relationship between the structure and function of phenolic acids. Copyright © 2016 Elsevier Ltd. All rights reserved.

Problem drinking among Flemish students: beverage type, early drinking onset and negative personal & social consequences.

Science.gov (United States)

De Bruyn, Sara; Wouters, Edwin; Ponnet, Koen; Van Damme, Joris; Maes, Lea; Van Hal, Guido

2018-02-12

Although alcohol is socially accepted in most Western societies, studies are clear about its associated negative consequences, especially among university and college students. Studies on the relationship between alcohol-related consequences and both beverage type and drinking onset, however, are scarce, especially in a European context. The aim of this research was, therefore, twofold: (1) What is the relationship between beverage type and the negative consequences experienced by students? and (2) Are these consequences determined by early drinking onset? We will examine these questions within the context of a wide range of alcohol-related consequences. The analyses are based on data collected by the inter-university project 'Head in the clouds?', measuring alcohol use among students in Flanders (Belgium). In total, a large dataset consisting of information from 19,253 anonymously participating students was available. Negative consequences were measured using a shortened version of the Core Alcohol and Drug Survey (CADS_D). Data were analysed using negative binomial regression. Results vary depending on the type of alcohol-related consequences: Personal negative consequences occur frequently among daily beer drinkers. However, a high rate of social negative consequences was recorded for both daily beer drinkers and daily spirits drinkers. Finally, early drinking onset was significantly associated with both personal and social negative consequences, and this association was especially strong between beer and spirits drinking onset and social negative consequences. Numerous negative consequences, both personal and social, are related to frequent beer and spirits drinking. Our findings indicate a close association between drinking beer and personal negative consequences as well as between drinking beer and/or spirits and social negative consequences. Similarly, early drinking onset has a major influence on the rates of both personal and social negative consequences

Liver Hypertension: Causes, Consequences and Prevention

Indian Academy of Sciences (India)

Table of contents. Liver Hypertension: Causes, Consequences and Prevention · Heart Pressure : Blood Pressure · Slide 3 · If you continue to have high BP · Doctor Measures Blood Pressure (BP): Medicines to Decrease BP · LIVER ~ ~ LIFE Rightists vs. Leftists · Slide 7 · Slide 8 · Slide 9 · Liver Spleen - Splanchnic ...

Uncertainty and sensitivity analysis in nuclear accident consequence assessment

International Nuclear Information System (INIS)

Karlberg, Olof.

1989-01-01

This report contains the results of a four year project in research contracts with the Nordic Cooperation in Nuclear Safety and the National Institute for Radiation Protection. An uncertainty/sensitivity analysis methodology consisting of Latin Hypercube sampling and regression analysis was applied to an accident consequence model. A number of input parameters were selected and the uncertainties related to these parameter were estimated within a Nordic group of experts. Individual doses, collective dose, health effects and their related uncertainties were then calculated for three release scenarios and for a representative sample of meteorological situations. From two of the scenarios the acute phase after an accident were simulated and from one the long time consequences. The most significant parameters were identified. The outer limits of the calculated uncertainty distributions are large and will grow to several order of magnitudes for the low probability consequences. The uncertainty in the expectation values are typical a factor 2-5 (1 Sigma). The variation in the model responses due to the variation of the weather parameters is fairly equal to the parameter uncertainty induced variation. The most important parameters showed out to be different for each pathway of exposure, which could be expected. However, the overall most important parameters are the wet deposition coefficient and the shielding factors. A general discussion of the usefulness of uncertainty analysis in consequence analysis is also given. (au)

Neurological Consequences of Obesity

Science.gov (United States)

O’Brien, Phillipe D.; Hinder, Lucy M.; Callaghan, Brian C.; Feldman, Eva L.

2017-01-01

Obesity, primarily a consequence of poor dietary choices and an increased sedentary lifestyle, has become a global pandemic that brings with it enormous medical, social, and economic challenges. Not only does obesity increase the risk of cardiovascular disease and certain cancers, but it is also recognized as a key driver of other metabolic syndrome (MetS) components. These components include insulin resistance, hyperglycemia with prediabetes or type 2 diabetes, dyslipidemia, and hypertension, and are underlying contributors to systemic metabolic dysfunction. More recently, obesity and diet-induced metabolic dysfunction have been identified as risk factors for the development of a wide variety of neurological disorders in both the central and peripheral nervous systems. An abundance of literature has shown that obesity is associated with mild cognitive impairment and altered hippocampal structure and function, and there is a robust correlation between obesity and Alzheimer’s type dementia. Similarly, many reports show that both the autonomic and somatic components of the peripheral nervous system are impacted by obesity. The autonomic nervous system, under control of the hypothalamus, displays altered catabolic and anabolic processes in obese individuals attributed to sympathetic-parasympathetic imbalances. A close association also exists between obesity and polyneuropathy, a complication most commonly found in prediabetic and diabetic patients, and is likely secondary to a combination of obesity-induced dyslipidemia with hyperglycemia. This review will outline the pathophysiological development of obesity and dyslipidemia, discuss the adverse impact of these conditions on the nervous system, and provide evidence for lipotoxicity and metabolic inflammation as the drivers underlying the neurological consequences of obesity. In addition, this review will examine the benefits of lifestyle and surgical interventions in obesity-induced neurological disorders. PMID

Technical progress and its strategic consequences

International Nuclear Information System (INIS)

Bouchard, G.

1999-01-01

The history of energy during recent decades has shown that technical progress can have consequences for the organisation of markets, company strategies and the economy in general, confounding all forecasts and going beyond simple technical change. As a consequence for example, improvements in the techniques concerning the exploration and production of hydrocarbons have led to the petrol 'counter-crisis', the reduction in the power of OPEC and undreamed of gains in wealth for certain countries. The progress in gas turbines has led to the reversal of the age-old tendency towards increases in the size of electricity production units and encouraged the liberation of this sector. When looking at the future it is therefore judicious to try and understand the forces at work, and the major trends which result. This is the aim of the articles in this edition of the Revue de l'Energie, published on the occasion of the European colloquium on 'Technical progress faced with the challenges of the energy sector in the future' organised by the Association of Energy Economists. (authors)

Evaluating the consequences of rheumatoid arthritis.

Science.gov (United States)

Sossong, Björn; Felder, Stefan; Wolff, Malte; Krüger, Klaus

2017-07-01

Patients and non-patients tend to attach different utility values to the state of suffering from specific illnesses. This observation naturally leads to the question whose utility values should be used as the basis in cost-effectiveness analysis (CEA). Intuitively, one would presume that patients are better informed about the consequences of their illness, and public authorities should, therefore, use the patients' utility values in CEA. Contrary to this presumption, it has been argued that society at large should determine which values are to be used and not the patients because, in the end, it is societal resources that are to be allocated. Against this background, we use data from a discrete choice experiment (DCE) that was completed by patients of rheumatoid arthritis (RA) and non-patients to explore the discrepancies between the two groups' utility estimates for typical consequences of RA. Our results indicate that both groups attach remarkably similar part-worth utilities to the symptoms pain, fatigue, and functional limitations. However, non-patients significantly undervalue the ability to work when compared to patients.

Genealogical analyses in open populations: the case of three Arab-derived Spanish horse breeds.

Science.gov (United States)

Cervantes, I; Gutiérrez, J P; Molina, A; Goyache, F; Valera, M

2009-10-01

This research assesses the genetic composition of three Arab-derived Spanish horse breeds as an example to highlight the major shortcomings related to genealogical analyses in open populations and to propose approaches useful to deal with this task. The studbooks of three Spanish Arab (SA)-derived horse breeds, Spanish Anglo-Arab (dAA), Hispano-Arab (dHA) and Spanish Sport Horse (dSSH) and those of their parental breeds SA, Spanish Purebred (SPB) and Thoroughbred (TB), totalling 211 754 individuals, were available. The genealogies of the dAA, dHA and dSSH were analysed not only using the corresponding studbook (breed exclusive dataset) but also including the genealogies of the founders from parental breeds (completed dataset). Coancestry analyses revealed that the present SA-derived populations share more genes with the Arab than with the other parental breeds. Effective population size was computed by accounting for migration rates to obtain an equivalent closed-population effective size ((eq)N(e)) of 39.2 for the dAA, 56.3 for dHA and 114.1 for dSSH. The essayed methodologies were useful for characterising populations involving migration. The consequences of the management of the analysed breeds are discussed. The results emphasize the need to include the complete genealogies of the individuals to attain reliable genealogical parameters.

Abortion — facts and consequences

OpenAIRE

Perinčić, Robert

1990-01-01

The author sets forth some of the most recent demographic data, important directions of legal documents as regards abortion, tackling medical and ethical problems of abortion. Some essentials particulars are also given as to the embryonic and foetal development. The whole paper concerns the problems of legal abortion during the first three months of pregnancy. The second part of the paper relates to the consequences of abortion affecting the physical and mental health of a woman as show...

Radiological consequence analysis with HEU and LEU fuels

Energy Technology Data Exchange (ETDEWEB)

Woodruff, W.L.; Warinner, D.K.; Matos, J.E.

1984-01-01

A model for estimating the radiological consequences from a hypothetical accident in HEU and LEU fueled research and test reactors is presented. Simple hand calculations based on fission product yield table inventories and non-site specific dispersion data may be adequate in many cases. However, more detailed inventories and site specific data on meteorological conditions and release rates and heights can result in substantial reductions in the dose estimates. LEU fuel gives essentially the same doses as HEU fuel. The plutonium buildup in the LEU fuel does not significantly increase the radiological consequences. The dose to the thyroid is the limiting dose. 10 references, 3 figures, 7 tables.

Radiological consequence analysis with HEU and LEU fuels

International Nuclear Information System (INIS)

Woodruff, W.L.; Warinner, D.K.; Matos, J.E.

1984-01-01

A model for estimating the radiological consequences from a hypothetical accident in HEU and LEU fueled research and test reactors is presented. Simple hand calculations based on fission product yield table inventories and non-site specific dispersion data may be adequate in many cases. However, more detailed inventories and site specific data on meteorological conditions and release rates and heights can result in substantial reductions in the dose estimates. LEU fuel gives essentially the same doses as HEU fuel. The plutonium buildup in the LEU fuel does not significantly increase the radiological consequences. The dose to the thyroid is the limiting dose. 10 references, 3 figures, 7 tables

Energy exploration in the Australian arid zone: constraints and environmental consequences

Energy Technology Data Exchange (ETDEWEB)

Buckley, R C

1982-03-01

The main constraints on energy exploration in the Australian arid zone are logistic, with limited additional constraints from Aboriginal reserves. The main consequence is increased access, with possible introduction of weeds and expansion of tourism and cattle grazing in consequence.

The Impact of Marijuana Legalization on Adolescent Use, Consequences, and Perceived Risk.

Science.gov (United States)

Estoup, Ashley C; Moise-Campbell, Claudine; Varma, Malini; Stewart, David G

2016-12-05

Currently, only four states have legalized recreational marijuana use for adults over 21 years of age. Therefore, little is known about the influence that legalization will have on adolescent marijuana use. This study examines how marijuana legalization has impacted the frequency and consequences of adolescent use in a sample of participants in a school-based, substance use intervention. We hypothesized that adolescents enrolled in the intervention in years after marijuana legalization would present with more problematic use compared to those enrolled prior, and that changes in the perceived risk of marijuana would be a mechanism of problematic use. Participants were 262 students enrolled in a school-based substance use intervention in 2010 to 2015. The Customary Drinking and Drug Use Record, Alcohol and Drug Use Consequences Questionnaire, and a decisional balance matrix were used to assess marijuana frequency, negative consequences, and perceived risk of use. A mediation model was used to test the degree to which marijuana legalization may lead to increased frequency and consequences of use through perceived risk. Findings indicated a significantly positive correlation between marijuana-related consequences and perceived risk post legalization. Despite relatively equal use between both groups, adolescents in the legalization group experienced higher levels of perceived risk and increased negative consequences. Due to the rising legalization status of marijuana in the United States, it is imperative that psychoeducation is provided to adults and adolescents about the consequences of underage marijuana use.

Biological and medical consequences of nuclear accidents

International Nuclear Information System (INIS)

Latarjet, R.

1988-01-01

The study of the medical and biological consequences of the nuclear accidents is a vast program. The Chernobyl accident has caused some thirty deceases: Some of them were rapid and the others occurred after a certain time. The particularity of these deaths was that the irradiation has been associated to burns and traumatisms. The lesson learnt from the Chernobyl accident is to treat the burn and the traumatism before treating the irradiation. Contrary to what the research workers believe, the first wave of deaths has passed between 15 and 35 days and it has not been followed by any others. But the therapeutic lesson drawn from the accident confirm the research workers results; for example: the radioactive doses band that determines where the therapy could be efficacious or not. the medical cares dispensed to the irradiated people in the hospital of Moscow has confirmed that the biochemical equilibrium of proteinic elements of blood has to be maintained, and the transfusion of the purified elements are very important to restore a patient to health, and the sterilization of the medium (room, food, bedding,etc...) of the patient is indispensable. Therefore, it is necessary to establish an international cooperation for providing enough sterilized rooms and specialists in the irradiation treatment. The genetic consequences and cancers from the Chernobyl accident have been discussed. It is impossible to detect these consequences because of their negligible percentages. (author)

Regeneration of articular cartilage by adipose tissue derived mesenchymal stem cells: perspectives from stem cell biology and molecular medicine.

Science.gov (United States)

Wu, Ling; Cai, Xiaoxiao; Zhang, Shu; Karperien, Marcel; Lin, Yunfeng

2013-05-01

Adipose-derived stem cells (ASCs) have been discovered for more than a decade. Due to the large numbers of cells that can be harvested with relatively little donor morbidity, they are considered to be an attractive alternative to bone marrow derived mesenchymal stem cells. Consequently, isolation and differentiation of ASCs draw great attention in the research of tissue engineering and regenerative medicine. Cartilage defects cause big therapeutic problems because of their low self-repair capacity. Application of ASCs in cartilage regeneration gives hope to treat cartilage defects with autologous stem cells. In recent years, a lot of studies have been performed to test the possibility of using ASCs to re-construct damaged cartilage tissue. In this article, we have reviewed the most up-to-date articles utilizing ASCs for cartilage regeneration in basic and translational research. Our topic covers differentiation of adipose tissue derived mesenchymal stem cells into chondrocytes, increased cartilage formation by co-culture of ASCs with chondrocytes and enhancing chondrogenic differentiation of ASCs by gene manipulation. Copyright © 2012 Wiley Periodicals, Inc.

Metabolic Consequences of Changing Dietary Patterns

African Journals Online (AJOL)

should be eaten well, lunch must be in one's fill, and food for dinner should be little', there has lately been a neglect of breakfast, whereas the use of fast foods and large dinners has become the trend. In the Australian Aboriginal population and in South Africa, the consequences of shifts from the hunter-gatherer dietary.

A joint analysis of determinants and performance consequences of ambidexterity

OpenAIRE

Eva M. Pertusa-Ortega; José F. Molina-Azorín

2018-01-01

Summary: This paper simultaneously analyzes antecedents and consequences of organizational ambidexterity. Regarding antecedents, the paper examines the influence of internal antecedents (organizational structure) and external antecedents (environmental dynamism). With regard to consequences, the paper analyzes the impact of ambidexterity on firm performance. Moreover, we use two different approaches to ambidexterity (structural and contextual perspectives). The findings show that a hybrid org...

Development of a Methodology for VHTR Accident Consequence Assessment

Energy Technology Data Exchange (ETDEWEB)

Lee, Joeun; Kim, Jintae; Jae, Moosung [Hanyang University, Seoul (Korea, Republic of)

2016-05-15

The substitution of the VHTR for burning fossil fuels conserves these hydrocarbon resources for other uses and eliminates the emissions of greenhouse. In Korea, for these reasons, constructing the VHTR plan for hydrogen production is in progress. In this study, the consequence analysis for the off-site releases of radioactive materials during severe accidents has been performed using the level 3 PRA technology. The offsite consequence analysis for a VHTR using the MACCS code has been performed. Since the passive system such as the RCCS(Reactor Cavity Cooling System) are equipped, the frequency of occurrence of accidents has been evaluated to be very low. For further study, the assessment for characteristic of VHTR safety system and precise quantification of its accident scenarios is expected to conduct more certain consequence analysis. This methodology shown in this study might contribute to enhancing the safety of VHTR design by utilizing the results having far lower effect on the environment than the LWRs.

Estimates of the financial consequences of nuclear-power-reactor accidents

International Nuclear Information System (INIS)

Strip, D.R.

1982-09-01

This report develops preliminary techniques for estimating the financial consequences of potential nuclear power reactor accidents. Offsite cost estimates are based on CRAC2 calculations. Costs are assigned to health effects as well as property damage. Onsite costs are estimated for worker health effects, replacement power, and cleanup costs. Several classes of costs are not included, such as indirect costs, socio-economic costs, and health care costs. Present value discounting is explained and then used to calculate the life cycle cost of the risks of potential reactor accidents. Results of the financial consequence estimates for 156 reactor-site combinations are summarized, and detailed estimates are provided in an appendix. The results indicate that, in general, onsite costs dominate the consequences of potential accidents

Prevention of the Causes and Consequences of Criticality Accidents: Measures Adopted in France; Prevention des Causes et des Consequences d'un Accident de Criticite: Solutions Adoptees en France

Energy Technology Data Exchange (ETDEWEB)

Fruchard, Y.; Lavie, J. -M. [Commissariat a l' Energie Atomique, Paris (France)

1966-05-15

It is important to guard against the risk of criticality accidents by seeking to prevent their occurrence through the elimination of their causes and also by taking steps to provide against their consequences. These two aspects are closely linked since the efforts made to elaborate preventive procedures are dictated by the importance of the repercussions which such accidents are liable to have in the human, economic and psychological spheres. The criticality accidents which have occurred in the nuclear industry, though small in number, do reveal the imperfect nature of the techniques adopted to prevent them, and they constitute the only available realistic basis for evaluating their consequences and developing suitable precautionary techniques. The authors give a detailed analysis of the known causes and consequences of past criticality accidents and on this basis make a number of comments in connection with the validity of traditional safety criteria, the probability of accidents for different types of operation, the characteristic accidents capable of serving as models, and the extent of possible radiological consequences. The measures adopted in France to limit the consequences of a possible criticality accident (location, design and lay-out of installations, accident detection dosimetry for exposed personnel) are briefly described after a short account of the criteria used in deciding on them. Finally, the authors discuss the economic implications of adopting particular precautionary measures and of applying them uniformly, taking due account of the question of reliability. (author) [French] II est important de se proteger contre les risques d'accidents de criticite en tentant, d'une part, de prevenir les accidents eux-memes par l'elimination de leurs causes, d'autre part, de parer a leurs consequences. Ces deux aspects sont tres lies: l'effort portant sur la prevention des accidents decoule de l'importance de leurs consequences sur les plans humain, economique

Superstability for Generalized Module Left Derivations and Generalized Module Derivations on a Banach Module (I

Directory of Open Access Journals (Sweden)

Rassias JM

2009-01-01

Full Text Available We discuss the superstability of generalized module left derivations and generalized module derivations on a Banach module. Let be a Banach algebra and a Banach -module, and . The mappings , and are defined and it is proved that if (resp., is dominated by then is a generalized (resp., linear module- left derivation and is a (resp., linear module- left derivation. It is also shown that if (resp., is dominated by then is a generalized (resp., linear module- derivation and is a (resp., linear module- derivation.

Consequences and detection of invalid exogeneity conditions

NARCIS (Netherlands)

Niemczyk, J.

2009-01-01

Estimators for econometric relationships require observations on at least as many exogenous variables as the model has unknown coefficients. This thesis examines techniques to classify variables as being either exogenous or endogenous, and investigates the consequences of invalid classifications.

A simple assessment scheme for severe accident consequences using release parameters

Energy Technology Data Exchange (ETDEWEB)

Silva, Kampanart, E-mail: kampanarts@tint.or.th [Thailand Institute of Nuclear Technology, 16 Vibhavadi-Rangsit Rd., Latyao, Chatuchak, 10900 (Thailand); Okamoto, Koji [The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8654 (Japan)

2016-08-15

Highlights: • Nuclear accident consequence index can assess overall consequences of an accident. • Correlations between the index and release parameters are developed. • Relation between the index and release amount follows power function. • The exponent of the power function is the key to the relation. - Abstract: Nuclear accident consequence index (NACI) which can assess the overall consequences of a severe accident on people and the environment is developed based on findings from previous studies. It consists of three indices: radiation effect index, relocation index and decontamination index. Though the NACI can cover large range of consequences, its assessment requires extensive resources. The authors then attempt to simplify the assessment, by investigating the relations between the release parameters and the NACI, in order to use the release parameters for severe accident consequence assessment instead of the NACI. NACI and its components increase significantly when the release amount is increased, while the influences of the release period and the release starting time on the NACI are nearly negligible. Relations between the release amount and the NACI and its components follow simple power functions (y = ax{sup b}). The exponent of the power functions seems to be the key to the relations. The exponent of the relation between the release amount and the NACI was around 0.8–1.0 when the release amount is smaller than 100 TBq, and it increased to around 1.3–1.4 when the release amount is equal to or larger than 100 TBq.

Unexpected source of Fukushima-derived radiocesium to the coastal ocean of Japan

Science.gov (United States)

Sanial, Virginie; Buesseler, Ken O.; Charette, Matthew A.; Nagao, Seiya

2017-12-01

Synthesizing published data, we provide a quantitative summary of the global biogeochemical cycle of vanadium (V), including both human-derived and natural fluxes. Through mining of V ores (130 × 109 g V/y) and extraction and combustion of fossil fuels (600 × 109 g V/y), humans are the predominant force in the geochemical cycle of V at Earth’s surface. Human emissions of V to the atmosphere are now likely to exceed background emissions by as much as a factor of 1.7, and, presumably, we have altered the deposition of V from the atmosphere by a similar amount. Excessive V in air and water has potential, but poorly documented, consequences for human health. Much of the atmospheric flux probably derives from emissions from the combustion of fossil fuels, but the magnitude of this flux depends on the type of fuel, with relatively low emissions from coal and higher contributions from heavy crude oils, tar sands bitumen, and petroleum coke. Increasing interest in petroleum derived from unconventional deposits is likely to lead to greater emissions of V to the atmosphere in the near future. Our analysis further suggests that the flux of V in rivers has been incremented by about 15% from human activities. Overall, the budget of dissolved V in the oceans is remarkably well balanced—with about 40 × 109 g V/y to 50 × 109 g V/y inputs and outputs, and a mean residence time for dissolved V in seawater of about 130,000 y with respect to inputs from rivers.

Characterisation of insulin-producing cells differentiated from tonsil derived mesenchymal stem cells.

Science.gov (United States)

Kim, So-Yeon; Kim, Ye-Ryung; Park, Woo-Jae; Kim, Han Su; Jung, Sung-Chul; Woo, So-Youn; Jo, Inho; Ryu, Kyung-Ha; Park, Joo-Won

2015-01-01

Tonsil-derived (T-) mesenchymal stem cells (MSCs) display mutilineage differentiation potential and self-renewal capacity and have potential as a banking source. Diabetes mellitus is a prevalent disease in modern society, and the transplantation of pancreatic progenitor cells or various stem cell-derived insulin-secreting cells has been suggested as a novel therapy for diabetes. The potential of T-MSCs to trans-differentiate into pancreatic progenitor cells or insulin-secreting cells has not yet been investigated. We examined the potential of human T-MSCs to trans-differentiate into pancreatic islet cells using two different methods based on β-mercaptoethanol and insulin-transferin-selenium, respectively. First, we compared the efficacy of the two methods for inducing differentiation into insulin-producing cells. We demonstrated that the insulin-transferin-selenium method is more efficient for inducing differentiation into insulin-secreting cells regardless of the source of the MSCs. Second, we compared the differentiation potential of two different MSC types: T-MSCs and adipose-derived MSCs (A-MSCs). T-MSCs had a differentiation capacity similar to that of A-MSCs and were capable of secreting insulin in response to glucose concentration. Islet-like clusters differentiated from T-MSCs had lower synaptotagmin-3, -5, -7, and -8 levels, and consequently lower secreted insulin levels than cells differentiated from A-MSCs. These results imply that T-MSCs can differentiate into functional pancreatic islet-like cells and could provide a novel, alternative cell therapy for diabetes mellitus. Copyright © 2015 International Society of Differentiation. Published by Elsevier B.V. All rights reserved.

The Professional Consequences of Whistleblowing by Nurses.

Science.gov (United States)

McDonald, Sally; Ahern, Kathy

2000-01-01

A study of 70 nurses self-described as whistleblowers and 25 who did not repot misconduct showed that whistleblowers experienced severe reprisals (demotion, reprimand, threats, rejection, pressure to resign). There were few professional consequences for those who remained silent. (SK)

Physiological consequences : Cardiopulmonary, vestibular, and sensory aspects

NARCIS (Netherlands)

Welsch, H.; Albery, W.; Banks, R.D.; Bles, W.

2000-01-01

Discussing the physiological consequences of enhanced fighter manoeuvrability (EFM), aspects of cardiopulmonary reactions will be seen during high G manoeuvres, especially the combination of negative G-load followed by high G-onset manoeuvres ("push-pull"). The aircraft's capability to reach high

Description and predictors of positive and negative alcohol-related consequences in the first year of college.

Science.gov (United States)

Barnett, Nancy P; Clerkin, Elise M; Wood, Mark; Monti, Peter M; O'Leary Tevyaw, Tracy; Corriveau, Donald; Fingeret, Allan; Kahler, Christopher W

2014-01-01

The purpose of this study was to establish the frequency of positive and negative alcohol-related consequences during the first year of college and to evaluate gender, race/ethnicity, time of year, alcohol use, and intoxication as predictors of consequences using frequent assessments. Participants (N = 1,053; 57.5% female) completed biweekly assessments of alcohol use and positive and negative alcohol-related consequences throughout the year. The majority of drinkers reported both positive and negative consequences. Having a good time and feeling less stressed were the most commonly reported positive consequences. Blackouts and getting physically sick were the most commonly endorsed negative consequences. At the weekly level, number of drinking days, drinks per drinking day, and estimated blood alcohol concentration (eBAC, reflecting intoxication) were significantly related to all consequences after controlling for demographics and time of year. Negative consequences had stronger associations with number of drinks and eBAC than positive consequences did. With each additional drink consumed on a drinking day, the incidence of negative consequences more than doubled (incidence rate ratio [IRR] = 2.34, 95% CI [2.19, 2.50]), whereas the incidence of positive consequences increased by about half (IRR = 1.51, 95% CI [1.47, 1.56]). The consequence with the largest gender difference was regretted sex, with women reporting it more often. Few racial/ethnic differences were found in report of negative consequences. Greater positive and negative consequences were endorsed at the beginning of both academic semesters. As number of drinks and eBAC increase, the relative odds of a negative consequence are higher than that of a positive consequence. Alcohol interventions could promote greater awareness of the likelihood of specific consequences and could highlight that positive consequences are associated with lower levels of drinking.

Adaptive synchronization of the complex dynamical network with non-derivative and derivative coupling

Energy Technology Data Exchange (ETDEWEB)

Xu Yuhua, E-mail: yuhuaxu2004@163.co [College of Information Science and Technology, Donghua University, Shanghai 201620 (China) and Department of Maths, Yunyang Teachers' College, Hubei 442000 (China); Zhou Wuneng, E-mail: wnzhou@163.co [College of Information Science and Technology, Donghua University, Shanghai 201620 (China); Fang Jian' an [College of Information Science and Technology, Donghua University, Shanghai 201620 (China); Sun Wen [School of Mathematics and Information, Yangtze University, Hubei Jingzhou 434023 (China)

2010-04-05

This Letter investigates the synchronization of a general complex dynamical network with non-derivative and derivative coupling. Based on LaSalle's invariance principle, adaptive synchronization criteria are obtained. Analytical result shows that under the designed adaptive controllers, a general complex dynamical network with non-derivative and derivative coupling can asymptotically synchronize to a given trajectory, and several useful criteria for synchronization are given. What is more, the coupling matrix is not assumed to be symmetric or irreducible. Finally, simulations results show the method is effective.

Influence of plume rise on the consequences of radioactive material releases

International Nuclear Information System (INIS)

Russo, A.J.; Wayland, J.R.; Ritchie, L.T.

1977-01-01

Estimates of health consequences resulting from a postulated nuclear reactor accident can be strongly dependent on the buoyant rise of the plume of released radioactive material. The sensitivity of the consequences of a postulated accident to two different plume rise models has been investigated. The results of these investigations are the subject of this report. One of the models includes the effects of emission angle, momentum, and radioactive heating of the released material. The difference in the consequence estimates from the two models can exceed an order of magnitude under some conditions, but in general the results are similar

Credit derivatives in emerging markets

OpenAIRE

Romain Rancière

2002-01-01

Credit Derivatives are securities that offer protection against credit or default risk of bonds or loans. The credit derivatives emerging market has grown rapidly and credit derivatives are widely used. This paper describes the emerging credit derivatives market structure. The current market activity is analyzed through elementary pricing dynamics and the study of the term structure of default risk. Focusing on the performance of credit derivatives in stress situation, including legal and mar...

Antibiotic resistance--consequences for animal health, welfare, and food production.

Science.gov (United States)

Bengtsson, Björn; Greko, Christina

2014-05-01

Most of the literature on the consequences of emergence and spread of bacteria resistant to antibiotics among animals relate to the potential impact on public health. But antibiotics are used to treat sick animals, and resistance in animal pathogens may lead to therapy failure. This has received little scientific attention, and therefore, in this article, we discuss examples that illustrate the possible impact of resistance on animal health and consequences thereof. For all animals, there may be a negative effect on health and welfare when diseases cannot be treated. Other consequences will vary depending on why and how different animal species are kept. Animals kept as companions or for sports often receive advanced care, and antibiotic resistance can lead to negative social and economic consequences for the owners. Further, spread of hospital-acquired infections can have an economic impact on the affected premises. As to animals kept for food production, antibiotics are not needed to promote growth, but, if infectious diseases cannot be treated when they occur, this can have a negative effect on the productivity and economy of affected businesses. Antibiotic resistance in animal bacteria can also have positive consequences by creating incentives for adoption of alternative regimes for treatment and prevention. It is probable that new antibiotic classes placed on the market in the future will not reach veterinary medicine, which further emphasizes the need to preserve the efficacy of currently available antibiotics through antibiotic stewardship. A cornerstone in this work is prevention, as healthy animals do not need antibiotics.

Ecological consequences of interactions between ants and honeydew-producing insects

OpenAIRE

Styrsky, John D; Eubanks, Micky D

2006-01-01

Interactions between ants and honeydew-producing hemipteran insects are abundant and widespread in arthropod food webs, yet their ecological consequences are very poorly known. Ant–hemipteran interactions have potentially broad ecological effects, because the presence of honeydew-producing hemipterans dramatically alters the abundance and predatory behaviour of ants on plants. We review several studies that investigate the consequences of ant–hemipteran interactions as ‘keystone interactions’...

Vitamin D derivatives

International Nuclear Information System (INIS)

Deluca, H.F.; Schnoes, H.K.; Napoli, J.L.; Fivizzani, M.A.

1982-01-01

The chemical preparation of 26,27-isotopically labelled vitamin D 3 derivatives of high specific activity is described. These labelled vitamin D derivatives are useful in the determination of vitamin D metabolite levels in the blood and tissues of man and animals. (U.K.)

An Icing Of Aircraft – Reasons, Consequences, Counteraction

Directory of Open Access Journals (Sweden)

Gębura Andrzej

2014-12-01

Full Text Available The article presents reasons of an helicopter’s ising as well as an aircraft’s ising. The maion attention is addressed a conteraction of an ising. Autors divide the problem an two groups: an ising of an airframe – mostly lifting surfaces, an ising of engines. According to authors reasons, an extension (first of all consequences of airframe’s ising considerably differ from seemingly similar events in an engine. The considerable attention is concentrated on a connteraction of consequences of an ising during the flight. The most complicated ising referes to helicopters, considering their particular aerodynamics characteristics. The autors dedicated is greather attention. Results reached during investigations of heating rotor blades in ITWL are presented.

Ingestion Pathway Consequences of an H-Separations Coil and Tube Failure

International Nuclear Information System (INIS)

Blanchard, A.

1999-01-01

The food ingestion consequences of an accidental release, scenario 1-RD-2.35, are evaluated for H-Separations. The sizes of land areas requiring the protective action of food interdiction are calculated. The consequences of the release are evaluated with the HOTSPOT model and an EXCEL spreadsheet

Credit derivatives and risk management

OpenAIRE

Michael S. Gibson

2007-01-01

The striking growth of credit derivatives suggests that market participants find them to be useful tools for risk management. I illustrate the value of credit derivatives with three examples. A commercial bank can use credit derivatives to manage the risk of its loan portfolio. An investment bank can use credit derivatives to manage the risks it incurs when underwriting securities. An investor, such as an insurance company, asset manager, or hedge fund, can use credit derivatives to align its...

Chernobyl: the actual facts and consequences

International Nuclear Information System (INIS)

Schmitt, Pierre

2011-01-01

In a first part, a Power Point presentation explains the technical reasons of the Chernobyl accident and recalls the environmental and health consequences on a short, middle and long term. In a second part, the author analyses the treatment by the media in France and shows how the population has been manipulated by nuclear opponents with the active complicity of some media

Predictors and consequences of job insecurity: Comparison of Slovakia and Estonia

Directory of Open Access Journals (Sweden)

Lucia Ištoňová

2016-03-01

Full Text Available Job insecurity is a significant current social issue in many European countries. Slovakia and Estonia significantly differ in the prevalence of job insecurity. The main aim of the present study was to compare Slovakia and Estonia in regard to job insecurity by looking at socio-demographic, job and organisational predictors and individual and social consequences based on ESS round five data. The secondary aim was to examine relationships between job insecurity and its predictors as well as job insecurity and its consequences. The analysis covered employed people with unlimited or limited contracts, working 40-50 hours per week, within the age range of 20-60. The results suggested significant differences in the predictors of job insecurity for Slovakia and Estonia. However, the individual, social and economic consequences of job insecurity were similar for both countries. This study contributes to an enhanced understanding of job insecurity predictors and consequences in the European region.

Sex differences in consequences of musculoskeletal pain

NARCIS (Netherlands)

Wijnhoven, H. A H; de Vet, Henrica C W; Picavet, H. Susan J

STUDY DESIGN. Cross-sectional population-based study. OBJECTIVE. To study sex differences in consequences of musculoskeletal pain (MP): limited functioning, work leave or disability, and healthcare use. SUMMARY OF BACKGROUND DATA. MP is a major public health problem in developed countries due to

Animal personalities : consequences for ecology and evolution

NARCIS (Netherlands)

Wolf, Max; Weissing, Franz J.

Personality differences are a widespread phenomenon throughout the animal kingdom. Past research has focused on the characterization of such differences and a quest for their proximate and ultimate causation. However, the consequences of these differences for ecology and evolution received much less

Children's cross-ethnic friendships: Antecedents and consequences

NARCIS (Netherlands)

Jugert, P.; Feddes, A.R.; Rutland, A.; Nesdale, D.; Brown, C.S.

2017-01-01

This chapter reviews recent research on the antecedents of cross-ethnic friendships, on friendship stability and quality, as well as on their consequences. It discusses structural, intergroup, and family factors and its relationship to cross-ethnic friendships. Research shows that cross-ethnic

Dynamical tendencies of health consequences caused by competitive risk factors

International Nuclear Information System (INIS)

Bykov, A.A.; Pronina, I.A.; Kudriavtsev, G.I.

2000-01-01

The paper deals with the generalized probabilistic approach for analyzing health consequences caused by various exposure factors. Formally basing on the competitive risk theory, it is introduced a general risk model for analysis the influence of environmental risk factors to human health. The usefulness of the model approach is in the opportunity of taking into account: time delay of impact and consequence manifestation; easy comparisons of exposure factors with different nature and various consequences (morbidity and mortality, carcinogenic and genetic); social and environmental components in overall mortality. Preliminary examples of comparative risk analysis are demonstrated on the Russian demography and environmental data with the attempt of characterizing the dynamical tendencies and evolution of introduced risk index. The prospects of the probabilistic approach and the results obtaining on this basis are discussed. (author)

Robots and people with dementia: Unintended consequences and moral hazard.

Science.gov (United States)

O'Brolcháin, Fiachra

2017-01-01

The use of social robots in elder care is entering the mainstream as robots become more sophisticated and populations age. While there are many potential benefits to the use of social robots in care for the older people, there are ethical challenges as well. This article focuses on the societal consequences of the adoption of social robots in care for people with dementia. Making extensive use of Alasdair MacIntyre's Dependent Rational Animals to discuss issues of unintended consequences and moral hazard, we contend that in choosing to avoid the vulnerability and dependency of human existence, a society blinds itself from the animal reality of humankind. The consequence of this is that a flourishing society, in which each individual is helped to develop the virtues essential to her flourishing, becomes harder to achieve.

The Iran nuclear ambitions and the international consequences; Les ambitions nucleaires de l'Iran et leurs consequences internationales

Energy Technology Data Exchange (ETDEWEB)

NONE

2005-01-15

This analysis of the Iran situation concerning the nuclear policy, is presented and discussed in three parts: the data and hypothesis of the iranian nuclear program, the regional strategy of Iran and evolution scenario and their consequences. (A.L.B.)

Long-term psychosocial consequences of surgical congenital malformations.

Science.gov (United States)

Diseth, Trond H; Emblem, Ragnhild

2017-10-01

Surgical congenital malformations often represent years of treatment, large number of hospital stays, treatment procedures, and long-term functional sequels affecting patients' psychosocial functioning. Both functional defects and psychosocial difficulties that occur commonly in childhood may pass through adolescence on to adulthood. This overview presents reports published over the past 3 decades to elucidate the long-term psychosocial consequences of surgical congenital malformations. Literature searches conducted on PubMed database revealed that less than 1% of all the records of surgical congenital malformations described long-term psychosocial consequences, but with diverse findings. This inconsistency may be due to methodological differences or deficiencies; especially in study design, patient sampling, and methods. Most of the studies revealed that the functional deficits may have great impact on patients' mental health, psychosocial functioning, and QoL; both short- and long-term negative consequences. Factors other than functional problems, e.g., repeated anesthesia, multiple hospitalization, traumatic treatment procedures, and parental dysfunctioning, may also predict long-term mental health and psychosocial functioning. Through multidisciplinary approach, pediatric surgeons should also be aware of deficits in emotional and psychosocial functioning. To achieve overall optimal psychosocial functioning, the challenge is to find a compromise between physically optimal treatment procedures and procedures that are not psychologically detrimental. Copyright © 2017. Published by Elsevier Inc.

Some consequences of a non-commutative space-time structure

International Nuclear Information System (INIS)

Vilela Mendes, R.

2005-01-01

The existence of a fundamental length (or fundamental time) has been conjectured in many contexts. Here we discuss some consequences of a fundamental constant of this type, which emerges as a consequence of deformation-stability considerations leading to a non-commutative space-time structure. This mathematically well defined structure is sufficiently constrained to allow for unambiguous experimental predictions. In particular we discuss the phase-space volume modifications and their relevance for the calculation of the Greisen-Zatsepin-Kuz'min sphere. The (small) corrections to the spectrum of the Coulomb problem are also computed. (orig.)

[Health consequences of smoking electronic cigarettes are poorly described].

Science.gov (United States)

Tøttenborg, Sandra Søgaard; Holm, Astrid Ledgaard; Wibholm, Niels Christoffer; Lange, Peter

2014-09-01

Despite increasing popularity, health consequences of vaping (smoking electronic cigarettes, e-cigarettes) are poorly described. Few studies suggest that vaping has less deleterious effects on lung function than smoking conventional cigarettes. One large study found that e-cigarettes were as efficient as nicotine patches in smoking cessation. The long-term consequences of vaping are however unknown and while some experts are open towards e-cigarettes as a safer way of satisfying nicotine addiction, others worry that vaping in addition to presenting a health hazard may lead to an increased number of smokers of conventional cigarettes.

CONSEQUENCES OF EMPLOYEE’S CUSTOMER ORIENTATION IN PUBLIC SERVICES

Directory of Open Access Journals (Sweden)

Andrada IACOB

2015-06-01

Full Text Available The goal of this paper is to explore the consequences of employee’s customer orientation in public services organizations. We will start with a literature review of the theory of customer orientation measurement and the consequences of this orientation at organizational and individual level. Then, the research methodology and results are presented. Conclusions, research limitations and future directions are included at the end of the paper. We identified positive direct effects of the employee customer orientation on organizational commitment and organizational identification, but no significant direct relationship with job satisfaction.

Radiological consequences of the Chernobyl reactor accident

International Nuclear Information System (INIS)

Hill, P.; Hille, R.

2003-01-01

The reactor accident at unit 4 of the Chernobyl nuclear power plant in Ukraine has deeply affected the living conditions of millions of people. Especially the health consequences have been of public concern up to the present and also been the subject of sometimes absurd claims. The current knowledge on the radiological consequences of the accident is reviewed. Though an increased hazard for some risk groups with high radiation exposure, e.g., liquidators, still cannot be totally excluded for the future, the majority of the population shows no statistically significant indication of radiation-induced illnesses. The contribution of the Research Center Juelich to the assessment of the post-accidental situation and psychological relief of the population is reported. The population groups still requiring special attention include, in particular, children growing up in highly contaminated regions and the liquidators of the years 1986 and 1987 deployed immediately after the accident. (author)

[Medical and biological consequences of nuclear disasters].

Science.gov (United States)

Stalpers, Lukas J A; van Dullemen, Simon; Franken, N A P Klaas

2012-01-01

Medical risks of radiation exaggerated; psychological risks underestimated. The discussion about atomic energy has become topical again following the nuclear accident in Fukushima. There is some argument about the gravity of medical and biological consequences of prolonged exposure to radiation. The risk of cancer following a low dose of radiation is usually estimated by linear extrapolation of the incidence of cancer among survivors of the atomic bombs dropped on Hiroshima and Nagasaki in 1945. The radiobiological linear-quadratic model (LQ-model) gives a more accurate description of observed data, is radiobiologically more plausible and is better supported by experimental and clinical data. On the basis of this model there is less risk of cancer being induced following radiation exposure. The gravest consequence of Chernobyl and Fukushima is not the medical and biological damage, but the psychological and economical impact on rescue workers and former inhabitants.

Radioecological and dosimetric consequences of the Chernobyl accident in France; Consequences radioecologiques et dosimetriques de l'accident de Tchernobyl en France

Energy Technology Data Exchange (ETDEWEB)

Renaud, Ph; Beaugelin, K; Maubert, H; Ledenvic, Ph [Inst. de Protection et de Surete Nucleaire, CEA Centre d' Etudes de Fontenay-aux-Roses, 92 (France)

1997-11-01

This study has as objective a survey of the radioecological and dosimetric consequences of the Chernobyl accident in France, as well as a prognosis for the years to come. It was requested by the Direction of Nuclear Installation Safety (DSIN) in relation to different organisms which effected measurements after this accident. It is based on the use of combined results of measurements and modelling by means of the code ASTRAL developed at IPSN. Various measurements obtained from five authorities and institutions, were made available, such as: activity of air and water, soil, processed food, agricultural and natural products. However, to achieve the survey still a modelling is needed. ASTRAL is a code for evaluating the ecological consequences of an accident. It allows establishing the correspondence between the soil Remnant Surface Activities (RSA, in Bq.m{sup -2}), the activity concentration of the agricultural production and the individual and collective doses resulting from external and internal exposures (due to inhalation and ingestion of contaminated nurture). The results of principal synthesis documents on the Chernobyl accident and its consequences were also used. The report is structured in nine sections, as follows: 1.Introduction; 2.Objective and methodology; 3.Characterization of radioactive depositions; 4;Remnant surface activities; 5.Contamination of agricultural products and foods; 6.Contamination of natural, semi-natural products and of drinking water; 7.Dosimetric evaluations; 8.Proposals for the environmental surveillance; 9.Conclusion. Finally, after ten years, one concludes that at presentthe dosimetric consequences of the Chernobyl accident in France were rather limited. For the period 1986-2046 the average individual effective dose estimated for the most struck zone is lower than 1500 {mu}Sv, which represents almost 1% of the average natural exposure for the same period. At present, the cesium 137 levels are at often inferior to those recorded

Consequences from use of reminiscence

DEFF Research Database (Denmark)

Gudex, Claire; Horsted, Charlotte; Jensen, Anders Møller

2010-01-01

Background: Reminiscence is the systematic use of memories and recollections to strengthen self-identity and self-worth. The study aim was to investigate the consequences for nursing home residents and staff of integrating reminiscence into daily nursing care. Methods: In this randomised study, ten...... than those in the Control Group for Personal accomplishment, Emotional exhaustion, Depersonalisation, ‘Attitude towards individual contact with residents’ and SF-12 self-rated mental health. At 12 months after start of reminiscence, staff in the Intervention Group had significantly better scores than...

Biological consequences of nuclear war

International Nuclear Information System (INIS)

Dubinin, N.P.

1986-01-01

Irradiation probability due to radionuclide fallout is shown to exceed 1 Gy even for the territories which have not been affected by nuclear weapons direct explosions. If some people survive in the nuclear war, their heredity would be affected. Genetic consequences of nuclear war complete the process of Homo sapiens disappearance from the Earth. Space weapons development will deteriorate the prospects of civilization ruin as a result of biological aftereffects of nuclear war and possible application of new arms, as well as chemical and biologic weapons

The consequences of non-normality

International Nuclear Information System (INIS)

Hip, I.; Lippert, Th.; Neff, H.; Schilling, K.; Schroers, W.

2002-01-01

The non-normality of Wilson-type lattice Dirac operators has important consequences - the application of the usual concepts from the textbook (hermitian) quantum mechanics should be reconsidered. This includes an appropriate definition of observables and the refinement of computational tools. We show that the truncated singular value expansion is the optimal approximation to the inverse operator D -1 and we prove that due to the γ 5 -hermiticity it is equivalent to γ 5 times the truncated eigenmode expansion of the hermitian Wilson-Dirac operator

Advanced glycation end-products: a biological consequence of lifestyle contributing to cancer disparity.

Science.gov (United States)

Turner, David P

2015-05-15

Low income, poor diet, obesity, and a lack of exercise are interrelated lifestyle factors that can profoundly alter our biologic make up to increase cancer risk, growth, and development. We recently reported a potential mechanistic link between carbohydrate-derived metabolites and cancer, which may provide a biologic consequence of lifestyle that can directly affect tumor biology. Advanced glycation end-products (AGE) are reactive metabolites produced as a by-product of sugar metabolism. Failure to remove these highly reactive metabolites can lead to protein damage, aberrant cell signaling, increased stress responses, and decreased genetic fidelity. Critically, AGE accumulation is also directly affected by our lifestyle choices and shows a race-specific, tumor-dependent pattern of accumulation in cancer patients. This review will discuss the contribution of AGEs to the cancer phenotype, with a particular emphasis on their biologic links with the socioeconomic and environmental risk factors that drive cancer disparity. Given the potential benefits of lifestyle changes and the potential biologic role of AGEs in promoting cancer, opportunities exist for collaborations affecting basic, translational, epidemiologic, and cancer prevention initiatives. ©2015 American Association for Cancer Research.

Enhanced degradation of spiro-insecticides and their leacher enol derivatives in soil by solarization and biosolarization techniques.

Science.gov (United States)

Fenoll, José; Garrido, Isabel; Vela, Nuria; Ros, Caridad; Navarro, Simón

2017-04-01

The leaching potential of three insecticides (spirodiclofen, spiromesifen, and spirotetramat) was assessed using disturbed soil columns. Small quantities of spirodiclofen and spiromesifen were detected in leachate fraction, while spirotetramat residues were not found in the leachates. In addition, the transformation products (enol derivatives) are relatively more mobile than the parent compounds and may leach into groundwater. Moreover, the use of disinfection soil techniques (solarization and biosolarization) to enhance their degradation rates in soil was investigated. The results show that both practices achieved a reduction in the number of juvenile nematodes, enhancing in a parallel way degradation rates of the insecticides and their enol derivatives as compared with the non-disinfected soil. This behavior can be mainly attributed to the increase in soil temperature and changes in microbial activity. All insecticides showed similar behavior under solarization and biosolarization conditions. As a consequence, both agronomic techniques could be considered as suitable strategies for detoxification of soils polluted with the studied pesticides.

The Consequences of Tongue Piercing on Oral and Periodontal Tissues

Science.gov (United States)

Sakellari, Dimitra

2014-01-01

This paper is discussing the potential consequences that may arise by the implementation of piercing in the oral cavity and is also categorizing the consequences according to their extent and severity. Furthermore, this paper is reviewing some possible oral hygiene methods that can prove to be auxiliary in decreasing the potential complications arising from oral piercing. This literature review is based on articles published from 1985 to 2012. PMID:24616814

Climate Change Consequences for Iowa'S Economy, Infrastructure, and Emergency Services

OpenAIRE

Swenson, David A.

2011-01-01

This is Chapter 6 in the state-mandated Regent's institution collaborative report, "Climate Change Impacts on Iowa, 2010: Report to the Governor and the Iowa General Assembly."Iowa's climate is changing, and that means Iowa's economy is changing. A changing Iowa economy will have consequences for agriculture, food production, Iowa's vaunted insurance agency, general energy use, Iowa's households, Iowa governments, and disaster services. This chapter profiles near and longer term consequences ...

Serious mental illness and negative substance use consequences among adults on probation.

Science.gov (United States)

Rossheim, Matthew E; Livingston, Melvin D; Lerch, Jennifer A; Taxman, Faye S; Walters, Scott T

2018-03-22

Adults on probation are at greater risk of both using substances and having a mental disorder compared to the general population. Several theories explain the relationship between substance use and poor mental health. However, the interaction between substance use, mental health, and substance-related consequences is not well understood. A better understanding of this relationship may help treatment programs become more responsive to people with serious mental illness (SMI). The current study used interview data from 313 adults on probation who reported recent substance use. We examined associations between SMI risk, substance use, and substance use consequences. A substantial proportion of the sample (37.5%) screened at risk of having a SMI. Adjusting for type and amount of substance use, those who screened at risk of having a SMI reported more negative substance use consequences. Significant interaction effects were observed between use of alcohol or opiates and SMI risk. Alcohol use was associated with more negative substance use consequences among those at risk of SMI, while opiate use was associated with more consequences among those not at risk. Programs are sorely needed to identify and treat adults with comorbid substance use and mental health symptoms, particularly for adults in the justice system. Clinicians should carefully consider how mental health may interact with substance use to exacerbate consequences.

Environmental consequences of new energy technology

International Nuclear Information System (INIS)

Svensson, Torbjoern

1991-09-01

This report summarises and assesses the environmental consequences associated with new energy technologies, with particular emphasis on their use for space heating supplies in the built environment. In the case of solar heating, it is primarily the processes associated with the production of the necessary materials and ground use requirements that can adversely affect the environment. There is also a certain risk associated with the leakage of heat transfer fluid. For heat stores, problem areas are primarily those associated with heating of the ground, discharge of foreign substances in connection with water treatment and conflicts of other users of ground water. The main adverse effects of heat pumps are their emissions of CFCs, which damage the ozone layer, utilisation of certain types of heat sources and the need to provide primary energy for mechanical drive of the pumps. All three of these new energy technologies are regarded as having less environmental consequences than conventional alternatives, although this assumes a change to less hazardous working media in heat pumps. A mutual comparison of the three technologies indicates that solar heating and heat stores have somewhat better environmental characteristics than heat pumps

Climate change consequences for the indoor environment

NARCIS (Netherlands)

Ariës, M.B.C.; Bluyssen, P.M.

2009-01-01

Scientists warn us about climate change and its effects on the outdoor environment. These effects can have significant consequences for the indoor environment, also in the Netherlands. Climate changes will affect different aspects of the indoor environment as well as the stakeholders of that indoor

The Activity of [60]Fullerene Derivatives Bearing Amine and Carboxylic Solubilizing Groups against Escherichia coli: A Comparative Study

Directory of Open Access Journals (Sweden)

Dmitry G. Deryabin

2014-01-01

Full Text Available We report a comparative investigation of the antibacterial activity of two water-soluble fullerene derivatives bearing protonated amine (AF and deprotonated carboxylic (CF groups appended to the fullerene cage via organic linkers. The negatively charged fullerene derivative CF showed no tendency to bind to the bacterial cells and, consequently, no significant antibacterial activity. In contrast, the compound AF loaded with cationic groups showed strong and partially irreversible binding to the negatively charged Escherichia coli K12 TG1 cells and to human erythrocytes, also possessing negative zeta potential. Adsorption of AF on the bacterial surface was visualized by atomic force microscopy revealing the formation of specific clusters (AF aggregates surrounding the bacterial cell. Incubation of E. coli K12 TG1 with AF led to a dose-dependent bactericidal effect with LD50 = 79.1 µM. The presence of human erythrocytes in the test medium decreased the AF antibacterial activity. Thus we reveal that the water-soluble cationic fullerene derivative AF possesses promising antibacterial activity, which might be utilized in the development of novel types of chemical disinfectants.

28 CFR 810.3 - Consequences of violating the conditions of supervision.

Science.gov (United States)

2010-07-01

... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Consequences of violating the conditions of supervision. 810.3 Section 810.3 Judicial Administration COURT SERVICES AND OFFENDER SUPERVISION AGENCY FOR THE DISTRICT OF COLUMBIA COMMUNITY SUPERVISION: ADMINISTRATIVE SANCTIONS § 810.3 Consequences of violating the conditions of supervision. ...

Deriving a Mutation Index of Carcinogenicity Using Protein Structure and Protein Interfaces

Science.gov (United States)

Hakas, Jarle; Pearl, Frances; Zvelebil, Marketa

2014-01-01

With the advent of Next Generation Sequencing the identification of mutations in the genomes of healthy and diseased tissues has become commonplace. While much progress has been made to elucidate the aetiology of disease processes in cancer, the contributions to disease that many individual mutations make remain to be characterised and their downstream consequences on cancer phenotypes remain to be understood. Missense mutations commonly occur in cancers and their consequences remain challenging to predict. However, this knowledge is becoming more vital, for both assessing disease progression and for stratifying drug treatment regimes. Coupled with structural data, comprehensive genomic databases of mutations such as the 1000 Genomes project and COSMIC give an opportunity to investigate general principles of how cancer mutations disrupt proteins and their interactions at the molecular and network level. We describe a comprehensive comparison of cancer and neutral missense mutations; by combining features derived from structural and interface properties we have developed a carcinogenicity predictor, InCa (Index of Carcinogenicity). Upon comparison with other methods, we observe that InCa can predict mutations that might not be detected by other methods. We also discuss general limitations shared by all predictors that attempt to predict driver mutations and discuss how this could impact high-throughput predictions. A web interface to a server implementation is publicly available at http://inca.icr.ac.uk/. PMID:24454733

Five potential consequences of climate change for invasive species.

Science.gov (United States)

Hellmann, Jessica J; Byers, James E; Bierwagen, Britta G; Dukes, Jeffrey S

2008-06-01

Scientific and societal unknowns make it difficult to predict how global environmental changes such as climate change and biological invasions will affect ecological systems. In the long term, these changes may have interacting effects and compound the uncertainty associated with each individual driver. Nonetheless, invasive species are likely to respond in ways that should be qualitatively predictable, and some of these responses will be distinct from those of native counterparts. We used the stages of invasion known as the "invasion pathway" to identify 5 nonexclusive consequences of climate change for invasive species: (1) altered transport and introduction mechanisms, (2) establishment of new invasive species, (3) altered impact of existing invasive species, (4) altered distribution of existing invasive species, and (5) altered effectiveness of control strategies. We then used these consequences to identify testable hypotheses about the responses of invasive species to climate change and provide suggestions for invasive-species management plans. The 5 consequences also emphasize the need for enhanced environmental monitoring and expanded coordination among entities involved in invasive-species management.

The accident consequence model of the German safety study

International Nuclear Information System (INIS)

Huebschmann, W.

1977-01-01

The accident consequence model essentially describes a) the diffusion in the atmosphere and deposition on the soil of radioactive material released from the reactor into the atmosphere; b) the irradiation exposure and health consequences of persons affected. It is used to calculate c) the number of persons suffering from acute or late damage, taking into account possible counteractions such as relocation or evacuation, and d) the total risk to the population from the various types of accident. The model, the underlying parameters and assumptions are described. The bone marrow dose distribution is shown for the case of late overpressure containment failure, which is discussed in the paper of Heuser/Kotthoff, combined with four typical weather conditions. The probability distribution functions for acute mortality, late incidence of cancer and genetic damage are evaluated, assuming a characteristic population distribution. The aim of these calculations is first the presentation of some results of the consequence model as an example, in second the identification of problems, which need possibly in a second phase of study to be evaluated in more detail. (orig.) [de

A consequence index approach to identifying radiological sabotage targets

International Nuclear Information System (INIS)

Altman, W.D.; Hockert, J.W.

1988-01-01

One of the threats to concern to facilities using significant quantities of radioactive material is radiological sabotage. Both the Department of Energy (DOE) and the U.S. Nuclear Regulatory Commission have issued guidance to facilities for radiological sabotage protection. At those facilities where the inventories of radioactive materials change frequently, there is an operational need for a technically defensible method of determining whether or not the inventory of radioactive material at a given facility poses a potential radiological sabotage risk. In order to determine quickly whether a building is a potential radiological sabotage target, Lawrence Livermore National Loaboratory (LLNL) has developed a radiological sabotage consequence index that provides a conservative estimate of the maximum potential off-site consequences of a radiological sabotage attempt involving the facility. This radiological sabotage consequence index can be used by safeguards and security staff to rapidly determine whether a change in building operations poses a potential radiological sabotage risk. In those cases where such a potential risk is identified, a more detailed radiological sabotage vulnerability analysis can be performed

40 CFR 1400.8 - Access to off-site consequence analysis information by Federal government officials.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Access to off-site consequence... MANAGEMENT PROGRAMS UNDER THE CLEAN AIR ACT SECTION 112(r)(7); DISTRIBUTION OF OFF-SITE CONSEQUENCE ANALYSIS INFORMATION DISTRIBUTION OF OFF-SITE CONSEQUENCE ANALYSIS INFORMATION Access to Off-Site Consequence Analysis...

Evaluating the consequences of salmon nutrients for riparian organisms: Linking condition metrics to stable isotopes.

Science.gov (United States)

Vizza, Carmella; Sanderson, Beth L; Coe, Holly J; Chaloner, Dominic T

2017-03-01

Stable isotope ratios (δ 13 C and δ 15 N) have been used extensively to trace nutrients from Pacific salmon, but salmon transfer more than carbon and nitrogen to stream ecosystems, such as phosphorus, minerals, proteins, and lipids. To examine the importance of these nutrients, metrics other than isotopes need to be considered, particularly when so few studies have made direct links between these nutrients and how they affect riparian organisms. Our study specifically examined δ 13 C and δ 15 N of riparian organisms from salmon and non-salmon streams in Idaho, USA, at different distances from the streams, and examined whether the quality of riparian plants and the body condition of invertebrates varied with access to these nutrients. Overall, quality and condition metrics did not mirror stable isotope patterns. Most notably, all riparian organisms exhibited elevated δ 15 N in salmon streams, but also with proximity to both stream types suggesting that both salmon and landscape factors may affect δ 15 N. The amount of nitrogen incorporated from Pacific salmon was low for all organisms (1950s. In addition, our results support those of other studies that have cautioned that inferences from natural abundance isotope data, particularly in conjunction with mixing models for salmon-derived nutrient percentage estimates, may be confounded by biogeochemical transformations of nitrogen, physiological processes, and even historical legacies of nitrogen sources. Critically, studies should move beyond simply describing isotopic patterns to focusing on the consequences of salmon-derived nutrients by quantifying the condition and fitness of organisms putatively using those resources.

The greenhouse effect: reality, consequences and solutions; L'effet de serre: realite, consequences et solutions

Energy Technology Data Exchange (ETDEWEB)

Ducroux, R.; Philippe, J.B.

2004-09-01

Devoted to the public, this synthesis on the greenhouse effect takes stock on the main questions of the context: what is the accuracy degree of simulations? From where are coming the greenhouse gases? What are their consequences in France and in the world, in particular in developing countries? What about some solutions? What are the main today research axis in national and international plans, that are likely to control this phenomena? (A.L.B.)

Waiting time and the psychosocial consequences of false-positive mammography

DEFF Research Database (Denmark)

Heleno, Bruno M.; Siersma, Volkert; Brodersen, John

2015-01-01

Background: There is wide variation in the psychosocial response to false-positive mammography. We aimed to assess whether women having to wait longer to exclude cancer had increased psychosocial consequences that persisted after cancer was ruled out. Findings: We selected women with false......-positive mammography (n = 272), screened for breast cancer in Copenhagen and Funen (Denmark) over a 1-year period. We measured psychosocial consequences immediately before women attended their recall visit and 1, 6, 18 and 36 months after women received their final diagnosis. After women were told that cancer had been...... ruled out, adverse psychosocial consequences decreased with time. We found no statistically significant differences between women who had cancer ruled out immediately at the recall visit (waiting time of 0) and women who had to wait longer before cancer was ruled out (waiting times 1-30, 30...

Consequence model of the German reactor safety study

International Nuclear Information System (INIS)

Bayer, A.; Aldrich, D.; Burkart, K.; Horsch, F.; Hubschmann, W.; Schueckler, M.; Vogt, S.

1979-01-01

The consequency model developed for phase A of the German Reactor Safety Study (RSS) is similar in many respects to its counterpart in WASH-1400. As in that previous study, the model describes the atmosphere dispersion and transport of radioactive material released from the containment during a postulated reactor accident, and predicts its interaction with and influence on man. Differences do exist between the two models however, for the following reasons: (1) to more adequately reflect central European conditions, (2) to include improved submodels, and (3) to apply additional data and knowledge that have become available since publication of WASH-1400. The consequence model as used in phase A of the German RSS is described, highlighting differences between it and the U.S. model

Post-ICU symptoms, consequences, and follow-up

DEFF Research Database (Denmark)

Svenningsen, Helle; Langhorn, Leanne; Ågård, Anne Sophie

2015-01-01

and rehabilitation in general hospital wards, rehabilitation facilities and at home. A prolonged stay in an ICU is associated with stressful memories that have long-term physical, mental and social consequences for health-related quality of life. We therefore conducted a data search to identify the programmes...

Separation: consequences for wealth in later life

NARCIS (Netherlands)

Dewilde, C.; van den Bosch, K.; van den Heede, A.; Börsch-Supan, A.; Brandt, M.; Hank, K.; Schröder, M.

2011-01-01

Over the course of their lives, a substantial minority of elderly European men and women have experienced the dissolution of one or more partner relationships through divorce or the ending of cohabitation. So far, most research into the economic consequences of (marital) separation has been based on

Consequences in Guatemala of the Chernobyl accident

International Nuclear Information System (INIS)

Perez Sabino, J.F.; Ayala Jimenez, R.E.

1997-01-01

Because of the long distance between Guatemala and Chernobyl, the country did not undergo direct consequences of radioactive contamination in the short term. However, the accident repercussions were evident in the medium and long-term, mainly in two sectors, the economic-political and the environmental sectors

Relationships between Arctic shrub dynamics and topographically derived hydrologic characteristics

International Nuclear Information System (INIS)

Naito, Adam T; Cairns, David M

2011-01-01

Shrub expansion is a global phenomenon that is gaining increased attention in the Arctic. Recent work employing the use of oblique aerial photographs suggested a consistent pattern of positive change in shrub cover across the North Slope of Alaska. The greatest amounts of change occurred in valley slopes and floodplains. We studied the association between shrub cover change and topographically derived hydrologic characteristics in five areas in northern Alaska between the 1970s and 2000s. Change in total shrub cover ranged from − 0.65% to 46.56%. Change in floodplain shrub cover ranged from 3.38% to 76.22%. Shrubs are preferentially expanding into areas of higher topographic wetness index (TWI) values where the potential for moisture accumulation or drainage is greater. In addition, we found that floodplain shrub development was strongly associated with high TWI values and a decreasing average distance between shrubs and the river bank. This suggests an interacting influence of substrate removal and stabilization as a consequence of increased vegetation cover.

Virtual reality publication of spiral ct-derived three-dimensional models: or, creation of spiral, CT-derived, three-dimensional VRML objects.

Science.gov (United States)

Tyszka, J M

1997-01-01

Three-dimensional models can be generated from slice images, such as those obtained from computed tomography (CT) and magnetic resonance imaging (MRI) using a variety of techniques. A popular method for rendering 3D anatomical models is the creation of polygonal mesh surfaces representing the boundary between tissues. Mesh surfaces can be rendered extremely quickly using conventional personal computers, without recourse to more expensive graphic workstations. The dissemination of three-dimensional (3D) models across the Internet has been made significantly easier by the definition of the Virtual Reality Markup Language (VRML) format. The VRML definition allows the parameters and relationships of 3D objects to be described in a text format. The text file can be transfered from a host computer to a remote client computer through the World Wide Web and viewed using readily available software (See Appendix). VRML is based on the definition of primitive 3D objects such as polygons and spheres. Consequently, the transition from a mesh surface derived from a clinical image data set to a VRML object is relatively simple, allowing for convenient and cost-effective dissemination of 3D clinical models across the internet.

A radiological consequence analysis with HEU and LEU fuels

International Nuclear Information System (INIS)

Woodruff, W.L.; Warinner, D.K.; Matos, J.E.

1985-01-01

A model for estimating the radiological consequences from a hypothetical accident in HEU and LEU fueled research and test reactors is presented. Simple hand calculations based on fission product yield table inventories and nonsite specific dispersion data may be adequate in many cases. However, more detailed inventories and site specific data on meteorological conditions and release rates and heights can result in substantial reductions in the dose estimates. LEU fuel gives essentially the same doses as HEU fuel. The plutonium buildup in the LEU fuel does not significantly increase the radiological consequences. The dose to the thyroid is the limiting dose. (author)

Effects of wind shear on the consequence model of the reactor safety study

International Nuclear Information System (INIS)

Sprung, J.L.; Church, H.W.

1977-01-01

The effects of explicit incorporation of wind shear into the consequence model of the Reactor Safety study have been investigated. The integral of exposure (X/Q) over area is unchanged by directional shear and decreased by speed shear. Consequence model predictions of early fatalities are always decreased by wind shear. Where early fatalities are decreased, survivors are subject to latent effects and, therefore, latent effects increase. However, aggregate early fatalities and latent effects always are decreased. Because the magnitude of these changes is within the present uncertainties of the consequence model, explicit incorporation of wind shear in the consequence model is not now warranted

4-Aminoquinoline derivatives

DEFF Research Database (Denmark)

Singh, Shailja; Agarwal, Drishti; Sharma, Kumkum

2016-01-01

and found them to be effective against Plasmodium falciparum under in vitro conditions. Further, we selected four most active derivatives 1m, 1o, 2c and 2j and evaluated their antimalarial potential against Plasmodium berghei in vivo. These 4-aminoquinolines cured BALB/c mice infected with P. berghei......Synthetic quinoline derivatives continue to be considered as candidates for new drug discovery if they act against CQ-resistant strains of malaria even after the widespread emergence of resistance to CQ. In this study, we explored the activities of two series of new 4-aminoquinoline derivatives...... for structure activity relationship to find lead molecules for treating multidrug-resistant Plasmodium falciparum and Plasmodium vivax....

A Computational Model of Selection by Consequences

Science.gov (United States)

McDowell, J. J.

2004-01-01

Darwinian selection by consequences was instantiated in a computational model that consisted of a repertoire of behaviors undergoing selection, reproduction, and mutation over many generations. The model in effect created a digital organism that emitted behavior continuously. The behavior of this digital organism was studied in three series of…

Consequences in Sweden of the Chernobyl accident

International Nuclear Information System (INIS)

Snihs, J.O.

1986-01-01

It summarizes the consequences in Sweden of the Chernobyl accident, describes the emergency response, the basis for decisions and countermeasures, the measurement strategies, the activity levels and doses and countermeasures and action levels used. Past and remaining problems are discussed and the major investigations and improvements are given. (author)

Stress in College Athletics: Causes, Consequences, Coping.

Science.gov (United States)

Humphrey, James H.; Yow, Deborah A.; Bowden, William W.

This book addresses the causes and consequences of stress in college sports and offers effective coping mechanisms to help individuals understand and control stressors and emotions in their environment. The chapters are: (1) "Understanding Stress"; (2) "Perceptions of Stress in College Athletics"; (3) "Stress among College Athletes"; (4) "Stress…

Incorporating Health and Behavioral Consequences of Child Abuse in Prevention Programs Targeting Female Adolescents.

Science.gov (United States)

Buzi, Ruth S.; Weinman, Maxine L.; Smith, Peggy B.

1998-01-01

Examined the health and behavioral consequences of child abuse, comparing parenting and never-pregnant teens. Both groups identified major consequences of suicide, prostitution, school drop-out, crime, and substance abuse. Parenting teens expressed interest in prevention programs that would address these consequences. Recommendations for child…

One decade after Chernobyl: Summing up the consequences

International Nuclear Information System (INIS)

Kaul, A.; Landfermann, H.; Thieme, M.

1996-01-01

During the week 8-12 April 1996, an international conference summing up the consequences of the Chernobyl disaster after one decade took place in Vienna. Organizers were the European Commission (EC), the International Atomic Energy Agency (IAEA) and the World Health Organization (WHO) (EC/IAEA/WHO 1996). One of the authors, A. Kaul, presented the outcome of the conference as given below to the IPRA 9 congress which was held in Vienna the following week. Two caveats have to be mentioned here: firstly, only facts actually reported and reviewed at the conference can be accounted for, and, secondly, according to the groundrules of the conference, the deadline for the background papers of the conference was the 9 February 1996, meaning that facts materializing after that time are not covered in this paper. The same applied to information given at the conference that was not properly reviewed and published. Reports, for example, given at the conference on an observed increase of thyroid cancers and leukemia among liquidators and of diabetes mellitus among children are not yet substantiated and are, therefore, not yet recognized as consequences. If corroborated, and it is obvious that all higher exposed groups should be closely monitored in the future, an update on the consequences will have to take this into account. 2 refs., 1 fig., 4 tabs

The Consequences of Mobility

DEFF Research Database (Denmark)

such as the following, related to this general interdisciplinary objective: • Language use in social networks, with special reference to language contact in interpersonal relations and interactions, including codeswitching and other manifestations of the construction of sociocultural identities in face......-to-face interaction • Language contact in society and in the world, and social hierarchies between languages: consequences of (mobility driven) language spread, and the ensuing processes of redefining linguistic differences and identities: language competition, language promotion and language discrimination...... • The complex relationship between language and culture: how can we envisage mobility and language spread across cultural areas without conceptualizing language as culturally neutral? (cp. the frequent conceptualization of English as culturally neutral) • Language contact in the individual: multiple language...

Emotional consequences of nuclear power plant disasters.

Science.gov (United States)

Bromet, Evelyn J

2014-02-01

The emotional consequences of nuclear power plant disasters include depression, anxiety, post-traumatic stress disorder, and medically unexplained somatic symptoms. These effects are often long term and associated with fears about developing cancer. Research on disasters involving radiation, particularly evidence from Chernobyl, indicates that mothers of young children and cleanup workers are the highest risk groups. The emotional consequences occur independently of the actual exposure received. In contrast, studies of children raised in the shadows of the Three Mile Island (TMI) and Chernobyl accidents suggest that although their self-rated health is less satisfactory than that of their peers, their emotional, academic, and psychosocial development is comparable. The importance of the psychological impact is underscored by its chronicity and by several studies showing that poor mental health is associated with physical health conditions, early mortality, disability, and overuse of medical services. Given the established increase in mental health problems following TMI and Chernobyl, it is likely that the same pattern will occur in residents and evacuees affected by the Fukushima meltdowns. Preliminary data from Fukushima indeed suggest that workers and mothers of young children are at risk of depression, anxiety, psychosomatic, and post-traumatic symptoms both as a direct result of their fears about radiation exposure and an indirect result of societal stigma. Thus, it is important that non-mental health providers learn to recognize and manage psychological symptoms and that medical programs be designed to reduce stigma and alleviate psychological suffering by integrating psychiatric and medical treatment within the walls of their clinics.Introduction of Emotional Consequences of Nuclear Power Plant Disasters (Video 2:15, http://links.lww.com/HP/A34).

The biological consequences of climate changes: An ecological and economic assessment

International Nuclear Information System (INIS)

Batie, S.S.; Shugart, H.H.

1991-01-01

The following subject areas are covered: (1) the level of climate change; (2) impacts of climate change on ecological systems (short-term (decadal), medium term (centenary), and long-term (millennial) effects); and (3) ecological consequences of climate change - evaluating the social costs (the problem of valuing consequences, intergenerational problem, and safe minimum standard strategies and policies)

The Consequence Deafness has on the Psychological and ...

African Journals Online (AJOL)

The Consequence Deafness has on the Psychological and Academic Development of deaf students. The case of Alpha special school for the deaf in Addis Ababa, Hermata and Mendera Junior School at Jimma Town.

Macroeconomic consequences of gender discrimination: a preliminary approach (refereed paper)

OpenAIRE

Melchor Fernandez; Yolanda Pena-Boquete

2011-01-01

Although the degree of gender wage discrimination has been estimated many times, its effects on the economy have not been too much studied, neither theoretically nor empirically. Consequently, in this paper we attempt to cover the existent void in this topic. First, we establish a theoretically framework of the macroeconomic consequences of gender discrimination and second, we attempt to check these results empirically. The existence of a degree of discrimination means that there is a wage di...

Latin American contributions to the GEM’s Earthquake Consequences Database

OpenAIRE

Cardona Arboleda, Omar Dario; Ordaz Schroeder, Mario Gustavo; Salgado Gálvez, Mario Andrés; Carreño Tibaduiza, Martha Liliana; Barbat Barbat, Horia Alejandro

2016-01-01

One of the projects of the Global Earthquake Model (GEM) was to develop a global earthquake consequences database (GEMECD) which served both to be an open and public repository of damages and losses on different types of elements at global level and also as a benchmark for the development of vulnerability models that could capture specific characteristics of the affected countries. The online earthquakes consequences database has information on 71 events where 14 correspond to events that occ...

Molecular interaction of acetylcholinesterase with carnosic acid derivatives: a neuroinformatics study.

Science.gov (United States)

Merad, M; Soufi, W; Ghalem, S; Boukli, F; Baig, M H; Ahmad, K; Kamal, Mohammad A

2014-04-01

Alzheimer's disease is a progressive degenerative disease of the brain marked by gradual and irreversible declines in cognitive functions. Acetylcholinesterase (AChE) plays a biological role in the termination of nerve impulse transmissions at cholinergic synapses by rapid hydrolysis of its substrate, "acetylcholine". The deficit level of acetylcholine leads to deprived nerve impulse transmission. Thus the cholinesterase inhibitors would reverse the deficit in acetylcholine level and consequently may reverse the memory impairments, which is characteristic of the Alzheimer's disease. The molecular interactions between AChE and Carnosic acid, a well known antioxidant substance found in the leaves of the rosemary plant has always been an area of interest. Here in this study we have performed in silico approach to identify carnosic acid derivatives having the potential of being a possible drug candidate against AChE. The best candidates were selected on the basis of the results of different scoring functions.

The Consequences of Human Behavior

Directory of Open Access Journals (Sweden)

Derek Hodgson

2012-12-01

Full Text Available Human behavior is founded on a complex interaction of influences that derive from sources both extraneous and intrinsic to the brain. It is the ways these various influences worked together in the past to fashion modern human cognition that can help elucidate the probable course of future human endeavor. A particular concern of this chapter is the way cognition has been shaped and continues to depend on prevailing environmental and ecological conditions. Whether the human predicament can be regarded simply as another response to such conditions similar to that of other organisms or something special will also be addressed. More specifically, it will be shown that, although the highly artificial niche in which most humans now live has had profound effects on ways of thinking, constraints deriving from a shared evolutionary heritage continue to have substantial effects on behavior. The way these exigencies interact will be explored in order to understand the implications for the future wellbeing of humanity.

Dynamics Under Location Uncertainty: Model Derivation, Modified Transport and Uncertainty Quantification

Science.gov (United States)

Resseguier, V.; Memin, E.; Chapron, B.; Fox-Kemper, B.

2017-12-01

In order to better observe and predict geophysical flows, ensemble-based data assimilation methods are of high importance. In such methods, an ensemble of random realizations represents the variety of the simulated flow's likely behaviors. For this purpose, randomness needs to be introduced in a suitable way and physically-based stochastic subgrid parametrizations are promising paths. This talk will propose a new kind of such a parametrization referred to as modeling under location uncertainty. The fluid velocity is decomposed into a resolved large-scale component and an aliased small-scale one. The first component is possibly random but time-correlated whereas the second is white-in-time but spatially-correlated and possibly inhomogeneous and anisotropic. With such a velocity, the material derivative of any - possibly active - tracer is modified. Three new terms appear: a correction of the large-scale advection, a multiplicative noise and a possibly heterogeneous and anisotropic diffusion. This parameterization naturally ensures attractive properties such as energy conservation for each realization. Additionally, this stochastic material derivative and the associated Reynolds' transport theorem offer a systematic method to derive stochastic models. In particular, we will discuss the consequences of the Quasi-Geostrophic assumptions in our framework. Depending on the turbulence amount, different models with different physical behaviors are obtained. Under strong turbulence assumptions, a simplified diagnosis of frontolysis and frontogenesis at the surface of the ocean is possible in this framework. A Surface Quasi-Geostrophic (SQG) model with a weaker noise influence has also been simulated. A single realization better represents small scales than a deterministic SQG model at the same resolution. Moreover, an ensemble accurately predicts extreme events, bifurcations as well as the amplitudes and the positions of the simulation errors. Figure 1 highlights this last

40 CFR 1400.5 - Internet access to certain off-site consequence analysis data elements.

Science.gov (United States)

2010-07-01

... consequence analysis data elements. 1400.5 Section 1400.5 Protection of Environment ENVIRONMENTAL PROTECTION... UNDER THE CLEAN AIR ACT SECTION 112(r)(7); DISTRIBUTION OF OFF-SITE CONSEQUENCE ANALYSIS INFORMATION DISTRIBUTION OF OFF-SITE CONSEQUENCE ANALYSIS INFORMATION Public Access § 1400.5 Internet access to certain off...

Caring for people with depression or with schizophrenia: Are the consequences different?

NARCIS (Netherlands)

van Wijngaarden, Bob; Koeter, Maarten; Knapp, Martin; Tansella, Michele; Thornicroft, Graham; Vázquez-Barquero, José-Luis; Schene, Aart

2009-01-01

Attention to caregiver consequences has been mainly restricted to caregivers of patients with schizophrenia. The few studies done in depression were conducted on small samples and/or with non-validated instruments. Caregiver consequences in depression and schizophrenia were measured with the

Social Causes and Consequences of Rejection Sensitivity

Science.gov (United States)

London, Bonita; Downey, Geraldine; Bonica, Cheryl; Paltin, Iris

2007-01-01

Predictions from the Rejection Sensitivity (RS) model concerning the social causes and consequences of RS were examined in a longitudinal study of 150 middle school students. Peer nominations of rejection, self-report measures of anxious and angry rejection expectations, and social anxiety, social withdrawal, and loneliness were assessed at two…

Globalisation; Its Implications and Consequences for Developing ...

African Journals Online (AJOL)

This paper attempts to look at the concept of globalisations and analyse its implications and consequences for developing nations in Africa. It is premised on the general perception that globalisations is a positive and powerful force for the improved material well-being of humankind, that would aid the developing countries ...

Radioecological and dosimetric consequences of the Chernobyl accident in France; Consequences radioecologiques et dosimetriques de l'accident de Tchernobyl en France

Energy Technology Data Exchange (ETDEWEB)

Renaud, Ph.; Beaugelin, K.; Maubert, H.; Ledenvic, Ph. [Inst. de Protection et de Surete Nucleaire, CEA Centre d' Etudes de Fontenay-aux-Roses, 92 (France)

1997-11-01

This study has as objective a survey of the radioecological and dosimetric consequences of the Chernobyl accident in France, as well as a prognosis for the years to come. It was requested by the Direction of Nuclear Installation Safety (DSIN) in relation to different organisms which effected measurements after this accident. It is based on the use of combined results of measurements and modelling by means of the code ASTRAL developed at IPSN. Various measurements obtained from five authorities and institutions, were made available, such as: activity of air and water, soil, processed food, agricultural and natural products. However, to achieve the survey still a modelling is needed. ASTRAL is a code for evaluating the ecological consequences of an accident. It allows establishing the correspondence between the soil Remnant Surface Activities (RSA, in Bq.m{sup -2}), the activity concentration of the agricultural production and the individual and collective doses resulting from external and internal exposures (due to inhalation and ingestion of contaminated nurture). The results of principal synthesis documents on the Chernobyl accident and its consequences were also used. The report is structured in nine sections, as follows: 1.Introduction; 2.Objective and methodology; 3.Characterization of radioactive depositions; 4;Remnant surface activities; 5.Contamination of agricultural products and foods; 6.Contamination of natural, semi-natural products and of drinking water; 7.Dosimetric evaluations; 8.Proposals for the environmental surveillance; 9.Conclusion. Finally, after ten years, one concludes that at presentthe dosimetric consequences of the Chernobyl accident in France were rather limited. For the period 1986-2046 the average individual effective dose estimated for the most struck zone is lower than 1500 {mu}Sv, which represents almost 1% of the average natural exposure for the same period. At present, the cesium 137 levels are at often inferior to those recorded

Overview of the reactor safety study consequence model

International Nuclear Information System (INIS)

Wall, I.B.; Yaniv, S.S.; Blond, R.M.; McGrath, P.E.; Church, H.W.; Wayland, J.R.

1977-01-01

The Reactor Safety Study (WASH-1400) is a comprehensive assessment of the potential risk to the public from accidents in light water power reactors. The engineering analysis of the plants is described in detail in the Reactor Safety Study: it provides an estimate of the probability versus magnitude of the release of radioactive material. The consequence model, which is the subject of this paper, describes the progression of the postulated accident after the release of the radioactive material from the containment. A brief discussion of the manner in which the consequence calculations are performed is presented. The emphasis in the description is on the models and data that differ significantly from those previously used for these types of assessments. The results of the risk calculations for 100 light water power reactors are summarized

Factor Structure of Individual Consequences for Teleworking Professionals

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John Campbell

2016-06-01

Full Text Available Despite the increasing popularity of telework, little is known about individual outcomes that arise particularly for teleworking professionals. We build on earlier research by examining the conceptual constructs of individual consequences from telework. We initially categorized consequences identified in the extant literature into five areas. However, this model was not supported by confirmatory factor analysis of survey data collected from 250 teleworking accounting professionals. Subsequent exploratory factor analysis revealed a more complex six-factor structure relating to (1 Effectiveness; (2 Self-assurance; (3 Working with Others; (4 Work Pressure; (5 Professional Image; and (6 Physicality. The results extend our understanding of latent constructs underlying telework by professional knowledge workers, and provide a basis for further refinement of our model based on empirical research and theoretical development.

Nuclear energy in Europe and its radiological consequences

International Nuclear Information System (INIS)

Kellerer, A.M.

1993-01-01

In a popular way, the author deals with the impacts of the Chernobyl reactor accident, and with the scientific relevance of reactions to and discussions about the consequences of peaceful nuclear energy use in Germany. He arrives at the conclusion that the use of nuclear energy in Europe does not have any radiological consequences for its population. Radioactive fission product release during normal operation is completely irrelevant in his view; a controversial problem being the potential release in the case of major accidents. According to the author, however, it would be irrational to put an end to the use of nuclear energy in an area where it shows a high degree of safety, and leave it on its own where it is threatening already now. (orig./HP) [de

Development of environmental consequence index (ECI) using fuzzy composite programming

International Nuclear Information System (INIS)

Arunraj, N.S.; Maiti, J.

2009-01-01

Estimation of environmental consequences of hazardous substances in chemical industries is a very difficult task owing to (i) diversity in the types of hazards and their effects, (ii) location, and (ii) uncertainty in input information. Several indices have been developed over the years to estimate the environmental consequences. In this paper, a critical literature review was done on the existing environmental indices to identify their applications and limitations. The existing indices lack in consideration of all environmental consequence factors such as material hazard factors, dispersion factors, environmental effects, and their uncertainty. A new methodology is proposed for the development of environmental consequence index (ECI), which can overcome the stated limitations. Moreover, the recently developed fuzzy composite programming (FCP) is used to take care of the uncertainty in estimation. ECI is applied to benzene extraction unit (BEU) of a petrochemical industry situated in eastern part of India. The ECI for all the eight sections of BEU are estimated and ranked. The results are compared with well-established indices such as Dow fire and explosion index, safety weight hazard index (SWeHI), and environmental accident index (EAI). The proposed ECI may outperform other indices based on its detailed consideration of the factors and performed equally to Dow F and E index, and EAI in most of the cases for the present application

Short- and long-term health consequences of sleep disruption

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Medic G

2017-05-01

Full Text Available Goran Medic,1,2 Micheline Wille,1 Michiel EH Hemels1 1Market Access, Horizon Pharma B.V., Utrecht, 2Unit of Pharmacoepidemiology & Pharmacoeconomics, Department of Pharmacy, University of Groningen, Groningen, The Netherlands Abstract: Sleep plays a vital role in brain function and systemic physiology across many body systems. Problems with sleep are widely prevalent and include deficits in quantity and quality of sleep; sleep problems that impact the continuity of sleep are collectively referred to as sleep disruptions. Numerous factors contribute to sleep disruption, ranging from lifestyle and environmental factors to sleep disorders and other medical conditions. Sleep disruptions have substantial adverse short- and long-term health consequences. A literature search was conducted to provide a nonsystematic review of these health consequences (this review was designed to be nonsystematic to better focus on the topics of interest due to the myriad parameters affected by sleep. Sleep disruption is associated with increased activity of the sympathetic nervous system and hypothalamic–pituitary–adrenal axis, metabolic effects, changes in circadian rhythms, and proinflammatory responses. In otherwise healthy adults, short-term consequences of sleep disruption include increased stress responsivity, somatic pain, reduced quality of life, emotional distress and mood disorders, and cognitive, memory, and performance deficits. For adolescents, psychosocial health, school performance, and risk-taking behaviors are impacted by sleep disruption. Behavioral problems and cognitive functioning are associated with sleep disruption in children. Long-term consequences of sleep disruption in otherwise healthy individuals include hypertension, dyslipidemia, cardiovascular disease, weight-related issues, metabolic syndrome, type 2 diabetes mellitus, and colorectal cancer. All-cause mortality is also increased in men with sleep disturbances. For those with

Children in Hot Cars Result in Fatal Consequences

Science.gov (United States)

... Health Tips » Holiday and Seasonal Children in Hot Cars Result in Fatal Consequences Emergency physicians are warning ... it bluntly, leaving your child in a hot car is like leaving your child in a lit ...

Consequence analysis for nuclear reactors, Yongbyon

International Nuclear Information System (INIS)

Kang, Taewook; Jae, Moosung

2017-01-01

Since the Fukushima nuclear power plant accidents in 2011, there have been an increased public anxiety about the safety of nuclear power plants in Korea. The lack of safeguards and facility aging issues at the Yongbyon nuclear facilities have increased doubts. In this study, the consequence analysis for the 5-MWe graphite-moderated reactor in North Korea was performed. Various accident scenarios including accidents at the interim spent fuel pool in the 5-MWe reactor have been developed and evaluated quantitatively. Since data on the design and safety system of nuclear facilities are currently insufficient, the release fractions were set by applying the alternative source terms made for utilization in the analysis of a severe accident by integrating the results of studies of severe accidents occurred before. The calculation results show the early fatality zero deaths and latent cancer fatality about only 13 deaths in Seoul. Thus, actual impacts of a radiological release will be psychological in terms of downwind perceptions and anxiety on the part of potentially exposed populations. Even considering the simultaneous accident occurrence in both 5-MWe graphite-moderated reactor and 100-MWt light water reactor, the consequence analysis using the MACCS2 code shows no significant damage to people in South Korea. (author)

Histone deacetylase inhibition enhances self renewal and cardioprotection by human cord blood-derived CD34 cells.

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Ilaria Burba

Full Text Available BACKGROUND: Use of peripheral blood- or bone marrow-derived progenitors for ischemic heart repair is a feasible option to induce neo-vascularization in ischemic tissues. These cells, named Endothelial Progenitors Cells (EPCs, have been extensively characterized phenotypically and functionally. The clinical efficacy of cardiac repair by EPCs cells remains, however, limited, due to cell autonomous defects as a consequence of risk factors. The devise of "enhancement" strategies has been therefore sought to improve repair ability of these cells and increase the clinical benefit. PRINCIPAL FINDINGS: Pharmacologic inhibition of histone deacetylases (HDACs is known to enhance hematopoietic stem cells engraftment by improvement of self renewal and inhibition of differentiation in the presence of mitogenic stimuli in vitro. In the present study cord blood-derived CD34(+ were pre-conditioned with the HDAC inhibitor Valproic Acid. This treatment affected stem cell growth and gene expression, and improved ischemic myocardium protection in an immunodeficient mouse model of myocardial infarction. CONCLUSIONS: Our results show that HDAC blockade leads to phenotype changes in CD34(+ cells with enhanced self renewal and cardioprotection.

Consequences count: against absolutism at the end of life.

Science.gov (United States)

Snelling, Paul C

2004-05-01

There has been a considerable amount of debate in the nursing literature about euthanasia, and especially the distinctions between acts and omissions, and killing and letting die. These distinctions are required by opponents of euthanasia to justify allowing some cases of passive euthanasia while forbidding all cases of active euthanasia. This paper adds to the debate by arguing that the position that absolutely forbids euthanasia is theoretically inconsistent. The paper first considers the place of moral theory in analysing moral problems, within the framework of the principles of biomedical ethics. It is argued that despite a moral pluralism that operates in many areas, the legal status of euthanasia is based upon an absolute deontological position against deliberate killing, which cannot be overridden by appeals to favourable consequences. In order that certain forms of passive euthanasia can be allowed, this position allows distinctions within three pairs of concepts--acts and omissions, killing and letting die, and ordinary and extraordinary means. A further method of justifying certain actions near the end of life is the doctrine of double effect. These paired concepts and the doctrine of double effect are analysed with special reference to their consequences. The application of the doctrine of double effect and the three distinctions relies on consideration of their consequences, allowing in practice what in theory is denied. This is important because it weakens the absolute case against euthanasia, which disallows any direct consequentialist appeal. If consequences count in the application of the doctrine and the distinctions, then they should also count directly prior to their application. This strengthens the argument for active euthanasia in certain cases.

Preventive Rad/Nuc Detection Equipment Categorization for Consequence Management

Energy Technology Data Exchange (ETDEWEB)

Buddemeier, B. R. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Musolino, S. V. [Brookhaven National Lab. (BNL), Upton, NY (United States); Klemic, G. [US Dept. of Homeland Security National Security Technology Lab., New York, NY (United States)

2017-06-01

The overall objective of this project is to research, evaluate, and test first responder preventive radiological/nuclear detection equipment (PRND) to provide state and local agencies with guidance on how to best use this equipment for response after a radiological/nuclear release or detonation. While the equipment being tested in this effort has been specifically designed for detection and interdiction operations, the fleet of PRND equipment can help fill critical needs for radiological instrumentation should a consequence management response take place. This effort will provide scientific guidance on the best way to deploy and operate this class of equipment for consequence management missions. With the support of the US Department of Homeland Security’s (DHS) Domestic Nuclear Detection Office (DNDO), PRND equipment has been placed into service at federal, state, and local agencies throughout the nation. If the equipment capability and limitations are taken into account, this large inventory can be repurposed to support the emergency response in the aftermath of a radiological of nuclear event. This report evaluates PRND equipment to define key categories of equipment and the types of missions they can be used for. This is important because there are over 100 different types of PRND equipment, often with significantly different capabilities with respect to the consequence management mission. The current DNDO draft NIMS PRND equipment types were used as a foundation and expanded, when necessary, to address key characteristics important for the consequence mission. Table 1 provides a summary of the PRND instrument categories developed for this effort. Also included on the table are some common response mission detection equipment categories that will be used for capability comparisons.

Enhanced Formation of Methylglyoxal-Derived Advanced Glycation End Products in Arabidopsis Under Ammonium Nutrition

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Klaudia Borysiuk

2018-05-01

Full Text Available Nitrate (NO3– and ammonium (NH4+ are prevalent nitrogen (N sources for plants. Although NH4+ should be the preferred form of N from the energetic point of view, ammonium nutrition often exhibits adverse effects on plant physiological functions and induces an important growth-limiting stress referred as ammonium syndrome. The effective incorporation of NH4+ into amino acid structures requires high activity of the mitochondrial tricarboxylic acid cycle and the glycolytic pathway. An unavoidable consequence of glycolytic metabolism is the production of methylglyoxal (MG, which is very toxic and inhibits cell growth in all types of organisms. Here, we aimed to investigate MG metabolism in Arabidopsis thaliana plants grown on NH4+ as a sole N source. We found that changes in activities of glycolytic enzymes enhanced MG production and that markedly elevated MG levels superseded the detoxification capability of the glyoxalase pathway. Consequently, the excessive accumulation of MG was directly involved in the induction of dicarbonyl stress by introducing MG-derived advanced glycation end products (MAGEs to proteins. The severe damage to proteins was not within the repair capacity of proteolytic enzymes. Collectively, our results suggest the impact of MG (mediated by MAGEs formation in proteins in the contribution to NH4+ toxicity symptoms in Arabidopsis.

Enhanced Formation of Methylglyoxal-Derived Advanced Glycation End Products in Arabidopsis Under Ammonium Nutrition

Science.gov (United States)

Borysiuk, Klaudia; Ostaszewska-Bugajska, Monika; Vaultier, Marie-Noëlle; Hasenfratz-Sauder, Marie-Paule; Szal, Bożena

2018-01-01

Nitrate (NO3–) and ammonium (NH4+) are prevalent nitrogen (N) sources for plants. Although NH4+ should be the preferred form of N from the energetic point of view, ammonium nutrition often exhibits adverse effects on plant physiological functions and induces an important growth-limiting stress referred as ammonium syndrome. The effective incorporation of NH4+ into amino acid structures requires high activity of the mitochondrial tricarboxylic acid cycle and the glycolytic pathway. An unavoidable consequence of glycolytic metabolism is the production of methylglyoxal (MG), which is very toxic and inhibits cell growth in all types of organisms. Here, we aimed to investigate MG metabolism in Arabidopsis thaliana plants grown on NH4+ as a sole N source. We found that changes in activities of glycolytic enzymes enhanced MG production and that markedly elevated MG levels superseded the detoxification capability of the glyoxalase pathway. Consequently, the excessive accumulation of MG was directly involved in the induction of dicarbonyl stress by introducing MG-derived advanced glycation end products (MAGEs) to proteins. The severe damage to proteins was not within the repair capacity of proteolytic enzymes. Collectively, our results suggest the impact of MG (mediated by MAGEs formation in proteins) in the contribution to NH4+ toxicity symptoms in Arabidopsis. PMID:29881392

The consequences of mobbing and possibilities of their measurement

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Vuksanović Mirjana

2013-01-01

Full Text Available This paper considers the consequences of mobbing in order to indicate possibilities for their measurement. Mobbing can be measured through its effects as the mental, physical and social consequences of mobbing are visible and can be quantified. The effect of mobbing can be expressed by the difference in the health of the victim of mobbing before and after exposure to the stressful mobbing activities. This can be compared through laboratory and specialist analysis of auto anamnestic data, accessible through the employee’s cumulative health record that is kept with the occupational health institution or with the employee’s chosen physician. It is expected the consequences of mobbing will correlate with the length and intensity of exposure, as well as with the personal “equation” of the victim and the circumstances of the surroundings. Using medical records, an expert could provide a statement on the degree of intangible damage made to the employee who has suffered harassment at work. The intensity of exposure to mobbing and the degree of pain caused can be measured by assessment scales. A major drawback of these instruments lies in their strong dependence on culture.

Mental health consequences of violence against women and girls.

Science.gov (United States)

Satyanarayana, Veena A; Chandra, Prabha S; Vaddiparti, Krishna

2015-09-01

Recent studies on mental health consequences of violence against women and girls were reviewed in a range of situations. Although several studies continued to show cross-sectional associations between child sexual abuse (CSA) and mental health outcomes, a few prospective studies showed a robust association between CSA and depression. Studies on the impact of dating violence are still at a nascent stage and focus on antecedents of violence rather than its consequences. Women at higher risk, such as adolescents, migrants, the homeless, and women in the perinatal period have been studied and specific vulnerabilities identified. Women reporting bidirectional violence had higher rates of depression and post-traumatic stress disorder (PTSD). Cumulative violence, severity of violence, and recent violence are associated with higher morbidity. Studies among women in conflict zones have emphasized the role of different forms of sexual and physical violence on mental health. Newer emerging areas that need more research include mental health consequences of women in conflict zones and among same sex relationships. There are also few studies on the violence experience of both older women and adolescents. The need to better delineate the psychopathology of complex manifestations of PTSD is underscored.

DETERMINANT FACTORS OF FINANCIAL REPORTING QUALITY AND ECONOMIC CONSEQUENCES

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Zaenal Fanani

2017-03-01

Full Text Available The aim of this research was to prove empirically the determining factors that influence the quality of financialreporting and the economic consequences, and there were influence differences of quality attributes of financialreporting to the economic consequences. The research samples were taken by purposive sampling so it obtained141 listed manufacturing businesses from 2001 to 2006. The research used four data analysis technique:auxiliary regression R2, confirmatory factor analysis, simple regression, and multiple regressions. The resultsshowed seven attributes, there were five attributes that gave contribution for financial reporting quality namelyaccrual quality, predictability, smoothness, relevance value, and conservatism while the persistence and timelinessgave small contribution. The five attributes were also different each other. From the thirteen determiningfactors, it showed nine factors that produced significant influences namely operation cycle, sales volatility,firm size, firm age, loss proportion, leverage, environmental risk, institutional ownership, market concentration,and auditor quality, while the other three, they were liquidity, managerial ownership, and investmentgrowth that were not significant. Testing results of economic consequences of quality of financial reportingshowed that the quality of factorial financial reporting influenced negatively and significantly toward informationasymmetry.

Legal consequences of divorce of marriage with respect to property

OpenAIRE

Paseková, Martina

2009-01-01

Seznam literatury - 60 - LEGAL CONSEQUENCES OF A DIVORCE IN PROPERTY AREA Summary Subject of my thesis is "Legal consequences of a divorce in property area". In the first chapters of this thesis I dealt in particular with the common property of spouses. I briefly described what belongs and what does not belong to the common property. Then I dealt with a divorce and its basic forms which are the so called divorce including identification of cause for breakdown of marriage, complicated divorce ...

Studies on Synthesis of Some Novel Heterocyclic Azlactone Derivatives and Imidazolinone Derivatives and their Antimicrobial Activity

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Rakesh N. Mistry

2005-01-01

Full Text Available p - Methyl benzoic acid on reaction with phosphorus pentachloride gives p - methyl benzoyl chloride derivative which on condensation with glycine gives p - methyl benzoyl glycine derivative. Now, this p - methyl benzoyl glycine derivative on condensation with various substituted aldehydes gives corresponding substituted 4 - [aryl methylidine] - 2 - [p - methyl phenyl] - oxazole - 5 - one derivatives [1(a-j]. Further, these derivatives [1(a-j] on condensation with 4 , 4’ - diamino diphenyl sulphone gives corresponding substituted imidazolinone - dibenzsulphone derivatives [2(a-j], on condensation with 4 , 4’ - diamino diphenyl methane gives corresponding substituted imidazolinone - dibenzmethane derivatives [3(a-j], on condensation with 4,4’- diamino benzanilide gives corresponding substituted imidazolinone - benzanilide derivatives [4(a-j] and on condensation with 2 - amino pyridine gives corresponding substituted imidazolinone - pyridine derivatives [5(a-j] respectively. Structure elucidation of synthesised compounds has been made on the basis of elemental analysis, I.R. spectral studies and 1H N.M.R. spectral studies. The antimicrobial activity of the synthesised compounds has been studied against the cultures “Staphylococcus aureus”, “Escherichia coli” and “Candela albicans”.

Predicting the consequences of species loss using size-structured biodiversity approaches

DEFF Research Database (Denmark)

Brose, Ulrich; Blanchard, Julia L.; Eklöf, Anna

2017-01-01

Understanding the consequences of species loss in complex ecological communities is one of the great challenges in current biodiversity research. For a long time, this topic has been addressed by traditional biodiversity experiments. Most of these approaches treat species as trait-free, taxonomic...... stability, and (iii) ecosystem functioning. Contrasting current expectations, size-structured approaches suggest that the loss of large species, that typically exploit most resource species, may lead to future food webs that are less interwoven and more structured by chains of interactions and compartments...... trait when analysing the consequences of biodiversity loss for natural ecosystems. Applying size-structured approaches provides an integrative ecological concept that enables a better understanding of each species' unique role across communities and the causes and consequences of biodiversity loss....

Employment consequences of depressive symptoms and work demands individually and combined

DEFF Research Database (Denmark)

Thielen, Karsten; Nygaard, Else; Andersen, Ingelise

2013-01-01

BACKGROUND: Denmark, like other Western countries, is recently burdened by increasingly high social spending on employment consequences caused by ill mental health. This might be the result of high work demands affecting persons with ill mental health. Therefore, this study assesses to what extent...... depressive symptoms and high work demands, individually and combined, have an effect on employment consequences. METHODS: We conducted a population-based 7-year longitudinal follow-up study with baseline information from the year 2000 on socio-demographics, lifestyle, depressive symptoms and work demands...... employment consequences irrespective of the kind and amount of work demands. This might be an effect on the level of work ability in general as well as partly the result of health selection and co-morbidity....

A study on the estimation of economic consequence of severe accident

International Nuclear Information System (INIS)

Hong, Dae Seok; Lee, Kun Jai; Jeong, Jong Tae

1996-01-01

A model to estimate economic consequence of severe accident provides some measure of the impact on the accident and enables to know the different effects of the accident described as same terms of cost and combined as necessary. Techniques to assess the consequences of accidents in terms of cost have many applications, for instance in examining countermeasure options, as part of either emergency planning or decision making after an accident. In this study, a model to estimate the accident economic consequence is developed appropriate to our country focused on PWR accident costs from a societal viewpoint. Societal costs are estimated by accounting for losses that directly affect the plant licensee, the public, the nuclear industry, or the electric utility industry after PWR accident

Effect of chondrocyte-derived early extracellular matrix on chondrogenesis of placenta-derived mesenchymal stem cells.

Science.gov (United States)

Park, Yong-Beom; Seo, Sinji; Kim, Jin-A; Heo, Jin-Chul; Lim, Young-Cheol; Ha, Chul-Won

2015-06-24

The extracellular matrix (ECM) surrounding cells contains a variety of proteins that provide structural support and regulate cellular functions. Previous studies have shown that decellularized ECM isolated from tissues or cultured cells can be used to improve cell differentiation in tissue engineering applications. In this study we evaluated the effect of decellularized chondrocyte-derived ECM (CDECM) on the chondrogenesis of human placenta-derived mesenchymal stem cells (hPDMSCs) in a pellet culture system. After incubation with or without chondrocyte-derived ECM in chondrogenic medium for 1 or 3 weeks, the sizes and wet masses of the cell pellets were compared with untreated controls (hPDMSCs incubated in chondrogenic medium without chondrocyte-derived ECM). In addition, histologic analysis of the cell pellets (Safranin O and collagen type II staining) and quantitative reverse transcription-PCR analysis of chondrogenic markers (aggrecan, collagen type II, and SOX9) were carried out. Our results showed that the sizes and masses of hPDMSC pellets incubated with chondrocyte-derived ECM were significantly higher than those of untreated controls. Differentiation of hPDMSCs (both with and without chondrocyte-derived ECM) was confirmed by Safranin O and collagen type II staining. Chondrogenic marker expression and glycosaminoglycan (GAG) levels were significantly higher in hPDMSC pellets incubated with chondrocyte-derived ECM compared with untreated controls, especially in cells precultured with chondrocyte-derived ECM for 7 d. Taken together, these results demonstrate that chondrocyte-derived ECM enhances the chondrogenesis of hPDMSCs, and this effect is further increased by preculture with chondrocyte-derived ECM. This preculture method for hPDMSC chondrogenesis represents a promising approach for cartilage tissue engineering.

The Fukushima Daiichi Accident. Technical Volume 4/5. Radiological Consequences

International Nuclear Information System (INIS)

2015-08-01

This technical volume describes the consequences associated with radioactivity and radiation from the accident at the Fukushima Daiichi nuclear power plant (NPP) for people and the environment. A number of international organizations have already issued reports on the potential health and environmental consequences of the accident, notably the World Health Organization (WHO) and the United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR). The intention of the assessments presented in this volume is to build on their work, using more recent data where available. Quantitative information arising from both personal and environmental monitoring has been provided by the Government of Japan. Section 4.1 provides the best estimates of the magnitude and form of radioactive releases during the accident to the atmosphere and directly into the surrounding sea. It also explains the movement of the discharged radionuclides through air and water and the eventual deposition of the atmospheric activity on land in Japan and other countries worldwide, as well as on the open oceans. The goal is to provide a consolidated repository of information on releases to, and levels of radionuclides in, the environment. Some of this information is used in the analyses in subsequent sections of this volume. Section 4.2 gives an overview of exposures to the main groups of emergency workers at the Fukushima Daiichi NPP, to groups of off-site workers and to members of the public. Where sufficient data are available, average effective dose and thyroid equivalent doses derived from personal measurements are compared with the results of previous assessments for specific locations, population groups and time periods. Section 4.3 summarizes relevant aspects of the system of radiation protection in place at the time of the accident. It includes an overview of the legislation and guidance used to implement the radiation protection framework in Japan. This section also provides a

The positive and negative consequences of multiple-choice testing.

Science.gov (United States)

Roediger, Henry L; Marsh, Elizabeth J

2005-09-01

Multiple-choice tests are commonly used in educational settings but with unknown effects on students' knowledge. The authors examined the consequences of taking a multiple-choice test on a later general knowledge test in which students were warned not to guess. A large positive testing effect was obtained: Prior testing of facts aided final cued-recall performance. However, prior testing also had negative consequences. Prior reading of a greater number of multiple-choice lures decreased the positive testing effect and increased production of multiple-choice lures as incorrect answers on the final test. Multiple-choice testing may inadvertently lead to the creation of false knowledge.

A radiological accident consequence assessment system for Hong Kong

International Nuclear Information System (INIS)

Wong, M.C.; Lam, H.K.

1993-01-01

An account is given of the Hong Kong Radiological Accident Consequence Assessment System which would be used to assess the potential consequences of an emergency situation involving atmospheric release of radioactive material. The system has the capability to acquire real-time meteorological information from the Observatory's network of automatic stations, synoptic stations in the nearby region as well as forecast data from numerical prediction models. The system makes use of these data to simulate the transport and dispersion of the released radioactive material. The effectiveness of protective action on the local population is also modeled. The system serves as a powerful aid in the protective action recommendation processes

CERN-derived analysis of lunar radiation backgrounds

Science.gov (United States)

Wilson, Thomas L.; Svoboda, Robert

1993-01-01

The Moon produces radiation which background-limits scientific experiments there. Early analyses of these backgrounds have either failed to take into consideration the effect of charm in particle physics (because they pre-dated its discovery), or have used branching ratios which are no longer strictly valid (due to new accelerator data). We are presently investigating an analytical program for deriving muon and neutrino spectra generated by the Moon, converting an existing CERN computer program known as GEANT which does the same for the Earth. In so doing, this will (1) determine an accurate prompt neutrino spectrum produced by the lunar surface; (2) determine the lunar subsurface particle flux; (3) determine the consequence of charm production physics upon the lunar background radiation environment; and (4) provide an analytical tool for the NASA astrophysics community with which to begin an assessment of the Moon as a scientific laboratory versus its particle radiation environment. This will be done on a recurring basis with the latest experimental results of the particle data groups at Earth-based high-energy accelerators, in particular with the latest branching ratios for charmed meson decay. This will be accomplished for the first time as a full 3-dimensional simulation.

Analysis the Human and Environmental Consequences of Power Pplants Using Combined Delphi and AHP Method

International Nuclear Information System (INIS)

Jozi, S. A.; Saffarian, Sh.; Shafiee, M.; Akbari, A.

2016-01-01

Power plants, due to the nature of their processes and activities and also by producing the effluents, emitting the air pollutants and hazardous wastes, have the potential to cause negative human and environmental consequences. Given the importance of the issue, for determining the most important consequences of Abadan Gas Power Plant and also their impact on the human and natural environment, as a case study, a questionnaire was developed with Delphi method. This questionnaire was distributed within the environmentalists and experts of power plant. The human and environmental consequences of Power Plant were analyzed by Multiple Criteria Decision-Making methods including AHP and eigenvector technique. For this purpose, with applying of AHP method, the hierarchical structure of the human and environmental consequences of Abadan Gas Power Plant was constructed and then the decision making matrix was formed. The pair wise matrices were formed separately for criteria pair wise comparisons with respect to severity and occurrence probability of indoor and outdoor environment of power plant .With entering the data in EXPERT CHOICE software, criteria weights were computed with applying the eigenvector method. Then the final weights of consequences in terms of severity and occurrence probability of risk were computed. The results from the compution of Abadan Gas Power Plant consequences indicate that in human consequences, shallow wounds with a .105 weight and in environmental consequences, air pollution by weighing 0.66 are the most important consequences of power plant. Finally, the most important executable strategies and actions for mitigation of negative human and environmental consequences were presented.

Magninos: Experimental consequences and constraints

International Nuclear Information System (INIS)

Raby, S.; West, G.B.

1987-01-01

A stable weakly interacting massive particle can simultaneously solve both the solar neutrino and missing mass problems. We have identified this particle with a neutral lepton with mass of order 5 to 15 GeV and an anomalous magnetic moment of order 10 -2 (in the natural units). We call this new particle a [magnino]. In one scenario, the magnino is the neutral component of an electroweak doublet. It has a charged partner with mass a few GeV heavier. In this talk the experimental consequences of the magnino, its charged partner and associated Higgs are discussed. 25 refs., 9 figs

The Relationship Between Antecedent and Consequence Factors with Safety Behaviour in PT.X

OpenAIRE

Fitriani, Apris; Nawawiwetu, Erwin Dyah

2017-01-01

Background : Safety behaviour is an act worker to minimize the possibility of accidents in workplace. Based on the Antecedents-Behaviour-Consequence (ABC) theory, safety behaviour of worker related with the antecedent and consequence factors. Purpose : The purpose of this research was to study the association between antecedent and consequence factors with safety behaviour of workers in Ring Frame Unit Spinning II PT. X. Methods : This was an observational descriptive research with cross sect...

A Principle and Winding Design of Consequent-Pole Bearingless Motors

Science.gov (United States)

Takenaga, Tomohiro; Kubota, Yutaka; Chiba, Akira; Fukao, Tadashi

Recently, bearingless motors have been developed to enhance motor drive systems with magnetic suspension. Several types of motors have been proposed as bearingless motors, such as induction, surface mounted permanent magnet, inset permanent magnet, interior permanent magnet, buried permanent magnet, homopolar, hybrid, and switched reluctance bearingless motors. Permanent magnet bearingless motors have been attracting more interests in these years because of the high efficiency. In this paper, a consequent-pole bearingless motor is proposed. A rotor has buried permanent magnets, of which polarities are like. The radial force of a consequent-pole bearingless motor is generated by dc current. Thus, rotational angular position is not needed in a magnetic suspension controller. Radial force variations caused by a rotor rotation are minimized by improving arrangement of stator suspension conductors. A prototype bearingless motor and its controller are built. In experiment, principles of magnetic suspension in the proposed consequent-pole bearingless drive are confirmed.

Incidence Probability of Delayed Health Consequences of the Chernobyl Accident

International Nuclear Information System (INIS)

Abdel-Ghani, A.H.; El-Naggar, A.M.; El-Kadi, A.A.

2000-01-01

During the first international Conference on the long -term consequences of the Chernobyl disaster in 1995 at Kiev, and also during the 1996 International Conference at Vienna, Summing up the consequences of the Chernobyl accident, the data regarding the delayed health consequences were mainly related to thyroid cancer, hereditary disorders, general morbidity, mortality and psychological disturbances. Contrary to expectations, the incidences of Leukemia and Soft Tissue tumors were similar to the spontaneous incident. The expected delayed effects, however, among the accident survivors, the liquidators and populations resident in contaminated areas would show higher incidence probability to Leukemia. These population groups have been continuously exposed to low level radiation both externally and internally. Application of the new ICRP concept of radiation-induced Detriment, and the Nominal Probability Coefficient for Cancer and hereditary effects for both workers and populations are used as the rationale to calculate the incidence probability of occurrence of delayed health effects of the Chernobyl accidents

Neuropsychological consequences of chronic drug use: relevance to treatment approaches

Directory of Open Access Journals (Sweden)

Jean Lud eCadet

2016-01-01

Full Text Available Heavy use of drugs impacts of the daily activities of individuals in these activities. Several groups of investigators have indeed documented changes in cognitive performance by individuals who have a long history of chronic drug use. In the case of marijuana, a wealth of information suggests that heavy long-term use of the drug may have neurobehavioral consequences in some individuals. In humans, heavy cocaine use is accompanied by neuropathological changes that might serve as substrates for cognitive dysfunctions. Similarly, methamphetamine users suffer from cognitive abnormalities that may be consequent to alterations in structures and functions. Here, we detail the evidence for these neuropsychological consequences. The review suggests that improving the care of our patients will necessarily depend on the better characterization of drug-induced cognitive phenotypes because they might inform the development of better pharmacological and behavioral interventions, with the goal of improving cognitive functions in these subsets of drug users.

Equivocating on the polluter-pays principle: The consequences for Pakistan.

Science.gov (United States)

Luken, Ralph A

2009-08-01

The polluter-pays principle has been widely implemented in OECD countries and credited for bring about a significant reduction in pollutant discharge. However, it has had only limited implementation in developing countries. The consequences of not implementing it in developing countries, to the extent they are documented, are limited to estimating the economic damages of environmental degradation. Yet there are several other but seldom documented negative consequences of the failure to implement the polluter-pays principle. These consequences are documented in the case of Pakistan. They include limited construction of effluent treatment plants, heavy dependence on the government and international donors for funding the only two operational common effluent treatment plants, significant operational issues at the two common effluent treatment plants, missed opportunities to build cost-effective common effluent treatment plants and minimal environmental improvements from isolated investments in individual effluent treatment plants in addition to the already documented significant level of environmental degradation due to uncontrolled pollutant discharge.

The effects of social and health consequence framing on heavy drinking intentions among college students.

Science.gov (United States)

Kingsbury, John H; Gibbons, Frederick X; Gerrard, Meg

2015-02-01

Many interventions targeting college student drinking have focused on negative health effects of drinking heavily; however, some research suggests that social factors may have a stronger influence on the drinking behaviour of young people. Moreover, few studies have examined message framing effects in the context of alcohol consumption. This study investigated the effects of social and health consequence framing on college students' intentions to engage in heavy drinking. This study used a 2 × 2 experimental design with an appended control condition. One hundred and twenty-four college students (74 women; M(age) = 18.9) participated in this study for course credit. Participants read vignettes that were ostensibly written by a recent graduate from the university, who described an episode of drinking in which he or she experienced either social or health consequences. These consequences were framed as either a gain (i.e., positive consequences of not drinking heavily) or a loss (i.e., negative consequences of drinking heavily). After reading the vignette, participants completed a measure of heavy drinking intentions. Regression analyses revealed that social consequences were associated with lower heavy drinking intentions when framed as a loss and that health consequences were associated with lower heavy drinking intentions when framed as a gain. These effects were stronger among those who reported higher (vs. lower) levels of previous drinking. Results suggest that interventions that focus on the negative health effects of heavy drinking may be improved by instead emphasizing the negative social consequences of drinking heavily and the positive health consequences of avoiding this behaviour. Statement of contribution What is already known on this subject? Previous studies have shown that gain frames are more effective than loss frames when highlighting the health consequences of health risk behaviours, such as heavy drinking. The heavy drinking behaviour of young

Evaluation of some non-toxic thiadiazole derivatives as bronze corrosion inhibitors in aqueous solution

International Nuclear Information System (INIS)

Varvara, Simona; Muresan, Liana Maria; Rahmouni, Kamal; Takenouti, Hisasi

2008-01-01

The inhibiting effect of four innoxious thiadiazole derivatives (2-mercapto-5-amino-1,3,4-thiadiazole (MAT), 2-mercapto-5-acetylamino-1,3,4-thiadiazole (MAcAT), 2-mercapto-5-methyl-1,3,4-thiadiazole (MMeT) and 2-mercapto-5-phenylamino-1,3,4-thiadiazole (MPhAT)) on bronze corrosion in an aerated solution of 0.2 g L -1 Na 2 SO 4 + 0.2 g L -1 NaHCO 3 at pH 5 was studied by potentiodynamic voltammetry and electrochemical impedance spectroscopy. The corrosion parameters determined from the polarisation curves indicate that the addition of the investigated thiadiazole derivatives decreases both cathodic and anodic current densities, due to an inhibition of the corrosion process, through the adsorption of thiadiazoles on the bronze surface. The inhibiting effect of the investigated organic compounds appears to be more pronounced on the anodic process than on the cathodic one and, except for the case MPhAT, it is enhanced by the increases of the inhibitors' concentration. The adsorption of the thiadiazole derivatives on bronze was confirmed by the presence of the nitrogen atoms in the EDX spectra of the bronze exposed to inhibitor-containing solutions. The magnitude of polarisation resistance values and, consequently, the inhibition efficiencies are influenced by the molecular structure of thiadiazole derivatives. The strongest inhibition was noticed in the presence of compounds with phenyl amino- or amino-functionalities in their molecules. The maximum protection efficiencies were obtained by addition of: 5 mM MAT (95.9%), 1 mM MAcAT (95.7%), 5 mM MMeT (92.6%) and 0.1 mM MPhAT (97%). EIS measurements also revealed that the inhibitor effectiveness of the optimal concentrations of thiadiazole is time-dependent

Evaluation of some non-toxic thiadiazole derivatives as bronze corrosion inhibitors in aqueous solution

Energy Technology Data Exchange (ETDEWEB)

Varvara, Simona [Department of Topography, ' 1 Decembrie 1918' University, 11-13 Nicolae Iorga Street, 510009 Alba Iulia (Romania); Muresan, Liana Maria [Department of Physical Chemistry, ' Babes-Bolyai' University, 11 Arany-Janos Street, 400028 Cluj-Napoca (Romania)], E-mail: limur@chem.ubbcluj.ro; Rahmouni, Kamal; Takenouti, Hisasi [UPMC LISE - UPR 15 of the CNRS, ' Pierre and Marie Curie' University, Paris (France)

2008-09-15

The inhibiting effect of four innoxious thiadiazole derivatives (2-mercapto-5-amino-1,3,4-thiadiazole (MAT), 2-mercapto-5-acetylamino-1,3,4-thiadiazole (MAcAT), 2-mercapto-5-methyl-1,3,4-thiadiazole (MMeT) and 2-mercapto-5-phenylamino-1,3,4-thiadiazole (MPhAT)) on bronze corrosion in an aerated solution of 0.2 g L{sup -1} Na{sub 2}SO{sub 4} + 0.2 g L{sup -1} NaHCO{sub 3} at pH 5 was studied by potentiodynamic voltammetry and electrochemical impedance spectroscopy. The corrosion parameters determined from the polarisation curves indicate that the addition of the investigated thiadiazole derivatives decreases both cathodic and anodic current densities, due to an inhibition of the corrosion process, through the adsorption of thiadiazoles on the bronze surface. The inhibiting effect of the investigated organic compounds appears to be more pronounced on the anodic process than on the cathodic one and, except for the case MPhAT, it is enhanced by the increases of the inhibitors' concentration. The adsorption of the thiadiazole derivatives on bronze was confirmed by the presence of the nitrogen atoms in the EDX spectra of the bronze exposed to inhibitor-containing solutions. The magnitude of polarisation resistance values and, consequently, the inhibition efficiencies are influenced by the molecular structure of thiadiazole derivatives. The strongest inhibition was noticed in the presence of compounds with phenyl amino- or amino-functionalities in their molecules. The maximum protection efficiencies were obtained by addition of: 5 mM MAT (95.9%), 1 mM MAcAT (95.7%), 5 mM MMeT (92.6%) and 0.1 mM MPhAT (97%). EIS measurements also revealed that the inhibitor effectiveness of the optimal concentrations of thiadiazole is time-dependent.

Induced pluripotent stem cell-derived cardiac progenitors differentiate to cardiomyocytes and form biosynthetic tissues.

Directory of Open Access Journals (Sweden)

Nicolas Christoforou

Full Text Available The mammalian heart has little capacity to regenerate, and following injury the myocardium is replaced by non-contractile scar tissue. Consequently, increased wall stress and workload on the remaining myocardium leads to chamber dilation, dysfunction, and heart failure. Cell-based therapy with an autologous, epigenetically reprogrammed, and cardiac-committed progenitor cell source could potentially reverse this process by replacing the damaged myocardium with functional tissue. However, it is unclear whether cardiac progenitor cell-derived cardiomyocytes are capable of attaining levels of structural and functional maturity comparable to that of terminally-fated cardiomyocytes. Here, we first describe the derivation of mouse induced pluripotent stem (iPS cells, which once differentiated allow for the enrichment of Nkx2-5(+ cardiac progenitors, and the cardiomyocyte-specific expression of the red fluorescent protein. We show that the cardiac progenitors are multipotent and capable of differentiating into endothelial cells, smooth muscle cells and cardiomyocytes. Moreover, cardiac progenitor selection corresponds to cKit(+ cell enrichment, while cardiomyocyte cell-lineage commitment is concomitant with dual expression of either cKit/Flk1 or cKit/Sca-1. We proceed to show that the cardiac progenitor-derived cardiomyocytes are capable of forming electrically and mechanically coupled large-scale 2D cell cultures with mature electrophysiological properties. Finally, we examine the cell progenitors' ability to form electromechanically coherent macroscopic tissues, using a physiologically relevant 3D culture model and demonstrate that following long-term culture the cardiomyocytes align, and form robust electromechanical connections throughout the volume of the biosynthetic tissue construct. We conclude that the iPS cell-derived cardiac progenitors are a robust cell source for tissue engineering applications and a 3D culture platform for pharmacological

Cost-consequence analysis of different active flowable hemostatic matrices in cardiac surgical procedures.

Science.gov (United States)

Makhija, D; Rock, M; Xiong, Y; Epstein, J D; Arnold, M R; Lattouf, O M; Calcaterra, D

2017-06-01

A recent retrospective comparative effectiveness study found that use of the FLOSEAL Hemostatic Matrix in cardiac surgery was associated with significantly lower risks of complications, blood transfusions, surgical revisions, and shorter length of surgery than use of SURGIFLO Hemostatic Matrix. These outcome improvements in cardiac surgery procedures may translate to economic savings for hospitals and payers. The objective of this study was to estimate the cost-consequence of two flowable hemostatic matrices (FLOSEAL or SURGIFLO) in cardiac surgeries for US hospitals. A cost-consequence model was constructed using clinical outcomes from a previously published retrospective comparative effectiveness study of FLOSEAL vs SURGIFLO in adult cardiac surgeries. The model accounted for the reported differences between these products in length of surgery, rates of major and minor complications, surgical revisions, and blood product transfusions. Costs were derived from Healthcare Cost and Utilization Project's National Inpatient Sample (NIS) 2012 database and converted to 2015 US dollars. Savings were modeled for a hospital performing 245 cardiac surgeries annually, as identified as the average for hospitals in the NIS dataset. One-way sensitivity analysis and probabilistic sensitivity analysis were performed to test model robustness. The results suggest that if FLOSEAL is utilized in a hospital that performs 245 mixed cardiac surgery procedures annually, 11 major complications, 31 minor complications, nine surgical revisions, 79 blood product transfusions, and 260.3 h of cumulative operating time could be avoided. These improved outcomes correspond to a net annualized saving of $1,532,896. Cost savings remained consistent between $1.3m and $1.8m and between $911k and $2.4m, even after accounting for the uncertainty around clinical and cost inputs, in a one-way and probabilistic sensitivity analysis, respectively. Outcome differences associated with FLOSEAL vs SURGIFLO

A study on the weather sampling method for probabilistic consequence analysis

International Nuclear Information System (INIS)

Oh, Hae Cheol

1996-02-01

The main task of probabilistic accident consequence analysis model is to predict the radiological situation and to provide a reliable quantitative data base for making decisions on countermeasures. The magnitude of accident consequence is depended on the characteristic of the accident and the weather coincident. In probabilistic accident consequence analysis, it is necessary to repeat the atmospheric dispersion calculation with several hundreds of weather sequences to predict the full distribution of consequences which may occur following a postulated accident release. It is desirable to select a representative sample of weather sequences from a meteorological record which is typical of the area over which the released radionuclides will disperse and which spans a sufficiently long period. The selection process is done by means of sampling techniques from a full year of hourly weather data characteristic of the plant site. In this study, the proposed Weighted importance sampling method selects proportional to the each bin size to closely approximate the true frequency distribution of weather condition at the site. The Weighted importance sampling method results in substantially less sampling uncertainty than the previous technique. The proposed technique can result in improve confidence in risk estimates

Energy derivatives, experiences in derivative trading from the natural gas industry : back to basics

International Nuclear Information System (INIS)

Dittmer, G.; Coyle, T.

1998-01-01

Some basic facts regarding derivatives in the electric power industry were discussed based on experiences in the natural gas industry. Derivatives were described as financial instruments that have no value of their own but derive their value from other assets, such as commodities. Futures and Options are the two forms of derivatives. Electricity as a commodity was characterized, and a historical parallel was drawn between deregulation in the natural gas and electric power industry. Short term and long term factors impacting the market and market dynamics impacting derivatives were identified. The latter include: (1) volatility, (2) liquidity, (3) correlations, and (4) price discovery. In contrast to the natural gas market, the electricity market is considered as lacking liquidity and in need of moving farther along the maturity timeline. The question of natural gas/ electricity convergence was also addressed refs., tabs., figs

Consequences of Predicted or Actual Asteroid Impacts

Science.gov (United States)

Chapman, C. R.

2003-12-01

Earth impact by an asteroid could have enormous physical and environmental consequences. Impactors larger than 2 km diameter could be so destructive as to threaten civilization. Since such events greatly exceed any other natural or man-made catastrophe, much extrapolation is necessary just to understand environmental implications (e.g. sudden global cooling, tsunami magnitude, toxic effects). Responses of vital elements of the ecosystem (e.g. agriculture) and of human society to such an impact are conjectural. For instance, response to the Blackout of 2003 was restrained, but response to 9/11 terrorism was arguably exaggerated and dysfunctional; would society be fragile or robust in the face of global catastrophe? Even small impacts, or predictions of impacts (accurate or faulty), could generate disproportionate responses, especially if news media reports are hyped or inaccurate or if responsible entities (e.g. military organizations in regions of conflict) are inadequately aware of the phenomenology of small impacts. Asteroid impact is the one geophysical hazard of high potential consequence with which we, fortunately, have essentially no historical experience. It is thus important that decision makers familiarize themselves with the hazard and that society (perhaps using a formal procedure, like a National Academy of Sciences study) evaluate the priority of addressing the hazard by (a) further telescopic searches for dangerous but still-undiscovered asteroids and (b) development of mitigation strategies (including deflection of an oncoming asteroid and on- Earth civil defense). I exemplify these issues by discussing several representative cases that span the range of parameters. Many of the specific physical consequences of impact involve effects like those of other geophysical disasters (flood, fire, earthquake, etc.), but the psychological and sociological aspects of predicted and actual impacts are distinctive. Standard economic cost/benefit analyses may not

Perceptual consequences of disrupted auditory nerve activity.

Science.gov (United States)

Zeng, Fan-Gang; Kong, Ying-Yee; Michalewski, Henry J; Starr, Arnold

2005-06-01

Perceptual consequences of disrupted auditory nerve activity were systematically studied in 21 subjects who had been clinically diagnosed with auditory neuropathy (AN), a recently defined disorder characterized by normal outer hair cell function but disrupted auditory nerve function. Neurological and electrophysical evidence suggests that disrupted auditory nerve activity is due to desynchronized or reduced neural activity or both. Psychophysical measures showed that the disrupted neural activity has minimal effects on intensity-related perception, such as loudness discrimination, pitch discrimination at high frequencies, and sound localization using interaural level differences. In contrast, the disrupted neural activity significantly impairs timing related perception, such as pitch discrimination at low frequencies, temporal integration, gap detection, temporal modulation detection, backward and forward masking, signal detection in noise, binaural beats, and sound localization using interaural time differences. These perceptual consequences are the opposite of what is typically observed in cochlear-impaired subjects who have impaired intensity perception but relatively normal temporal processing after taking their impaired intensity perception into account. These differences in perceptual consequences between auditory neuropathy and cochlear damage suggest the use of different neural codes in auditory perception: a suboptimal spike count code for intensity processing, a synchronized spike code for temporal processing, and a duplex code for frequency processing. We also proposed two underlying physiological models based on desynchronized and reduced discharge in the auditory nerve to successfully account for the observed neurological and behavioral data. These methods and measures cannot differentiate between these two AN models, but future studies using electric stimulation of the auditory nerve via a cochlear implant might. These results not only show the unique

40 CFR 1400.9 - Access to off-site consequence analysis information by State and local government officials.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Access to off-site consequence... CONSEQUENCE ANALYSIS INFORMATION DISTRIBUTION OF OFF-SITE CONSEQUENCE ANALYSIS INFORMATION Access to Off-Site Consequence Analysis Information by Government Officials. § 1400.9 Access to off-site consequence analysis...

Antecedents and consequences of work engagement among nurses.

Science.gov (United States)

Sohrabizadeh, Sanaz; Sayfouri, Nasrin

2014-11-01

Engaged nurses have high levels of energy and are enthusiastic about their work which impacts quality of health care services. However, in the context of Iran, due to observed burnout, work engagement among nurses necessitates immediate exploration. This investigation aimed to identify a suitable work engagement model in nursing profession in hospitals according to the hypothesized model and to determine antecedents and consequences related to work engagement among nurses. In this cross-sectional study, a questionnaire was given to 279 randomly-selected nurses working in two general teaching hospitals of Shiraz University of Medical Sciences (Shiraz, Iran) to measure antecedents and consequences of work engagement using the Saks's (2005) model. Structural Equation Modeling was used to examine the model fitness. Two paths were added using LISREL software. The resulting model showed good fitness indices (χ(2) = 23.62, AGFI = 0.93, CFI = 0.97, RMSEA = 0.07) and all the coefficients of the paths were significant (t ≥ 2, t ≤ -2). A significant correlation was found between work engagement and model variables. Paying adequate attention to the antecedents of work engagement can enhance the quality of performance among nurses. Additionally, rewards, organizational and supervisory supports, and job characteristics should be taken into consideration to establish work engagement among nurses. Further researches are required to identify other probable antecedents and consequences of nursing work engagement, which might be related to specific cultural settings.

Alcohol-Related Consequences among Intercollegiate Student Athletes: The Role of Drinking Motives

Science.gov (United States)

Doumas, Diana M.

2013-01-01

This study examined drinking motives as predictors of alcohol-related consequences among student athletes and nonathletes. Results indicated that the highest level of alcohol-related consequences was reported by student athletes with high levels of both coping and conformity motives. (Contains 2 tables and 2 figures.)

Children in Hot Cars Result in Fatal Consequences

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Full Text Available ... Health Tips » Holiday and Seasonal Children in Hot Cars Result in Fatal Consequences Emergency physicians are warning ... with leaving anyone, especially children in hot, unventilated vehicles during the summer. Children throughout the country die ...

Children in Hot Cars Result in Fatal Consequences

Medline Plus

Full Text Available ... Health Tips » Holiday and Seasonal Children in Hot Cars Result in Fatal Consequences Emergency physicians are warning ... it bluntly, leaving your child in a hot car is like leaving your child in a lit ...