Benford's Law and Continuous Dependent Random Variables
Becker, Thealexa; Miller, Steven J; Ronan, Ryan; Strauch, Frederick W
2011-01-01
Many systems exhibit a digit bias. For example, the first digit base 10 of the Fibonacci numbers, or of $2^n$, equals 1 not 10% or 11% of the time, as one would expect if all digits were equally likely, but about 30% of the time. This phenomenon, known as Benford's Law, has many applications, ranging from detecting tax fraud for the IRS to analyzing round-off errors in computer science. The central question is determining which data sets follow Benford's law. Inspired by natural processes such as particle decay, our work examines models for the decomposition of conserved quantities. We prove that in many instances the distribution of lengths of the resulting pieces converges to Benford behavior as the number of divisions grow. The main difficulty is that the resulting random variables are dependent, which we handle by a careful analysis of the dependencies and tools from Fourier analysis to obtain quantified convergence rates.
Simple dependent pairs of exponential and uniform random variables
A. J. Lawrance; Lewis, Peter Adrian Walter
1982-01-01
A random-coefficient linear function of two independent exponential variables yielding a third exponential variable is used in the construction of simple, dependent pairs of exponential variables. By employing antithetic exponential variables, the constructions are developed to encompass negative dependency. By employing negative exponentiation, the constructions yield simple multiplicative-based models for dependent uniform pairs. The ranges of dependency allowable in the models are assessed...
LARGE DEVIATIONS AND MODERATE DEVIATIONS FOR SUMS OF NEGATIVELY DEPENDENT RANDOM VARIABLES
Institute of Scientific and Technical Information of China (English)
Liu Li; Wan Chenggao; Feng Yanqin
2011-01-01
In this article, we obtain the large deviations and moderate deviations for negatively dependent (ND) and non-identically distributed random variables defined on (-∞, +∞). The results show that for some non-identical random variables, precise large deviations and moderate deviations remain insensitive to negative dependence structure.
Directory of Open Access Journals (Sweden)
Yongfeng Wu
2014-01-01
Full Text Available The authors first present a Rosenthal inequality for sequence of extended negatively dependent (END random variables. By means of the Rosenthal inequality, the authors obtain some complete moment convergence and mean convergence results for arrays of rowwise END random variables. The results in this paper extend and improve the corresponding theorems by Hu and Taylor (1997.
Institute of Scientific and Technical Information of China (English)
无
2010-01-01
This paper studies the moderate deviations of real-valued extended negatively dependent(END) random variables with consistently varying tails.The moderate deviations of partial sums are first given.The results are then used to establish the necessary and sufficient conditions for the moderate deviations of random sums under certain circumstances.
Non-uniform approximations for sums of discrete m-dependent random variables
Vellaisamy, P.; Cekanavicius, V.
2013-01-01
Non-uniform estimates are obtained for Poisson, compound Poisson, translated Poisson, negative binomial and binomial approximations to sums of of m-dependent integer-valued random variables. Estimates for Wasserstein metric also follow easily from our results. The results are then exemplified by the approximation of Poisson binomial distribution, 2-runs and $m$-dependent $(k_1,k_2)$-events.
Tail dependence of random variables from ARCH and heavy tailed bilinear models
Institute of Scientific and Technical Information of China (English)
PAN; Jiazhu(潘家柱)
2002-01-01
Discussed in this paper is the dependent structure in the tails of distributions of random variables from some heavy-tailed stationary nonlinear time series. One class of models discussed is the first-order autoregressive conditional heteroscedastic (ARCH) process introduced by Engle (1982). The other class is the simple first-order bilinear models driven by heavy-tailed innovations. We give some explicit formulas for the asymptotic values of conditional probabilities used for measuring the tail dependence between two random variables from these models. Our results have significant meanings in finance.
Central limit theorem for the Banach-valued weakly dependent random variables
International Nuclear Information System (INIS)
The central limit theorem (CLT) for the Banach-valued weakly dependent random variables is proved. In proving CLT convergence of finite-measured (i.e. cylindrical) distributions is established. A weak compactness of the family of measures generated by a certain sequence is confirmed. The continuity of the limiting field is checked
An edgeworth expansion for a sum of M-Dependent random variables
Directory of Open Access Journals (Sweden)
Wan Soo Rhee
1985-01-01
Full Text Available Given a sequence X1,X2,…,Xn of m-dependent random variables with moments of order 3+α (0<α≦1, we give an Edgeworth expansion of the distribution of Sσ−1(S=X1+X2+…+Xn, σ2=ES2 under the assumption that E[exp(it Sσ1] is small away from the origin. The result is of the best possible order.
The Randomized Dependence Coefficient
Lopez-Paz, David; Hennig, Philipp; Schölkopf, Bernhard
2013-01-01
We introduce the Randomized Dependence Coefficient (RDC), a measure of non-linear dependence between random variables of arbitrary dimension based on the Hirschfeld-Gebelein-R\\'enyi Maximum Correlation Coefficient. RDC is defined in terms of correlation of random non-linear copula projections; it is invariant with respect to marginal distribution transformations, has low computational cost and is easy to implement: just five lines of R code, included at the end of the paper.
Matricially free random variables
Lenczewski, Romuald
2008-01-01
We show that the operatorial framework developed by Voiculescu for free random variables can be extended to arrays of random variables whose multiplication imitates matricial multiplication. The associated notion of independence, called matricial freeness, can be viewed as a generalization of both freeness and monotone independence. At the same time, the sums of matricially free random variables, called random pseudomatrices, are closely related to Gaussian random matrices. The main results presented in this paper concern the standard and tracial central limit theorems for random pseudomatrices and the corresponding limit distributions which can be viewed as matricial generalizations of semicirle laws.
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Penzlin AI
2015-10-01
Full Text Available Ana Isabel Penzlin,1 Timo Siepmann,2 Ben Min-Woo Illigens,3 Kerstin Weidner,4 Martin Siepmann4 1Institute of Clinical Pharmacology, 2Department of Neurology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Saxony, Germany; 3Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; 4Department of Psychotherapy and Psychosomatic Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Saxony, Germany Background and objective: In patients with alcohol dependence, ethyl-toxic damage of vasomotor and cardiac autonomic nerve fibers leads to autonomic imbalance with neurovascular and cardiac dysfunction, the latter resulting in reduced heart rate variability (HRV. Autonomic imbalance is linked to increased craving and cardiovascular mortality. In this study, we sought to assess the effects of HRV biofeedback training on HRV, vasomotor function, craving, and anxiety. Methods: We conducted a randomized controlled study in 48 patients (14 females, ages 25–59 years undergoing inpatient rehabilitation treatment. In the treatment group, patients (n=24 attended six sessions of HRV biofeedback over 2 weeks in addition to standard rehabilitative care, whereas, in the control group, subjects received standard care only. Psychometric testing for craving (Obsessive Compulsive Drinking Scale, anxiety (Symptom Checklist-90-Revised, HRV assessment using coefficient of variation of R-R intervals (CVNN analysis, and vasomotor function assessment using laser Doppler flowmetry were performed at baseline, immediately after completion of treatment or control period, and 3 and 6 weeks afterward (follow-ups 1 and 2. Results: Psychometric testing showed decreased craving in the biofeedback group immediately postintervention (OCDS scores: 8.6±7.9 post-biofeedback versus 13.7±11.0 baseline [mean ± standard deviation], P<0.05, whereas craving was unchanged at
Directory of Open Access Journals (Sweden)
Ming He
2015-11-01
Full Text Available We propose a random effects panel data model with both spatially correlated error components and spatially lagged dependent variables. We focus on diagnostic testing procedures and derive Lagrange multiplier (LM test statistics for a variety of hypotheses within this model. We first construct the joint LM test for both the individual random effects and the two spatial effects (spatial error correlation and spatial lag dependence. We then provide LM tests for the individual random effects and for the two spatial effects separately. In addition, in order to guard against local model misspecification, we derive locally adjusted (robust LM tests based on the Bera and Yoon principle (Bera and Yoon, 1993. We conduct a small Monte Carlo simulation to show the good finite sample performances of these LM test statistics and revisit the cigarette demand example in Baltagi and Levin (1992 to illustrate our testing procedures.
Directory of Open Access Journals (Sweden)
Guillaume Marrelec
Full Text Available The use of mutual information as a similarity measure in agglomerative hierarchical clustering (AHC raises an important issue: some correction needs to be applied for the dimensionality of variables. In this work, we formulate the decision of merging dependent multivariate normal variables in an AHC procedure as a Bayesian model comparison. We found that the Bayesian formulation naturally shrinks the empirical covariance matrix towards a matrix set a priori (e.g., the identity, provides an automated stopping rule, and corrects for dimensionality using a term that scales up the measure as a function of the dimensionality of the variables. Also, the resulting log Bayes factor is asymptotically proportional to the plug-in estimate of mutual information, with an additive correction for dimensionality in agreement with the Bayesian information criterion. We investigated the behavior of these Bayesian alternatives (in exact and asymptotic forms to mutual information on simulated and real data. An encouraging result was first derived on simulations: the hierarchical clustering based on the log Bayes factor outperformed off-the-shelf clustering techniques as well as raw and normalized mutual information in terms of classification accuracy. On a toy example, we found that the Bayesian approaches led to results that were similar to those of mutual information clustering techniques, with the advantage of an automated thresholding. On real functional magnetic resonance imaging (fMRI datasets measuring brain activity, it identified clusters consistent with the established outcome of standard procedures. On this application, normalized mutual information had a highly atypical behavior, in the sense that it systematically favored very large clusters. These initial experiments suggest that the proposed Bayesian alternatives to mutual information are a useful new tool for hierarchical clustering.
Barcella, William; Iorio, Maria De; Baio, Gianluca; Malone-Lee, James
2016-04-15
Lower urinary tract symptoms can indicate the presence of urinary tract infection (UTI), a condition that if it becomes chronic requires expensive and time consuming care as well as leading to reduced quality of life. Detecting the presence and gravity of an infection from the earliest symptoms is then highly valuable. Typically, white blood cell (WBC) count measured in a sample of urine is used to assess UTI. We consider clinical data from 1341 patients in their first visit in which UTI (i.e. WBC ≥ 1) is diagnosed. In addition, for each patient, a clinical profile of 34 symptoms was recorded. In this paper, we propose a Bayesian nonparametric regression model based on the Dirichlet process prior aimed at providing the clinicians with a meaningful clustering of the patients based on both the WBC (response variable) and possible patterns within the symptoms profiles (covariates). This is achieved by assuming a probability model for the symptoms as well as for the response variable. To identify the symptoms most associated to UTI, we specify a spike and slab base measure for the regression coefficients: this induces dependence of symptoms selection on cluster assignment. Posterior inference is performed through Markov Chain Monte Carlo methods. PMID:26536840
Strong Decomposition of Random Variables
DEFF Research Database (Denmark)
Hoffmann-Jørgensen, Jørgen; Kagan, Abram M.; Pitt, Loren D.;
2007-01-01
A random variable X is stongly decomposable if X=Y+Z where Y=Φ(X) and Z=X-Φ(X) are independent non-degenerated random variables (called the components). It is shown that at least one of the components is singular, and we derive a necessary and sufficient condition for strong decomposability of a...... discrete random variable....
WEAK UNCORRELATEDNESS OF RANDOM VARIABLES
Institute of Scientific and Technical Information of China (English)
Sofiya Ostrovska
2006-01-01
New measures of independence for n random variables, based on their moments, are studied. A scale of degrees of independence for random variables which starts with uncorrelatedness (for n = 2) and finishes at independence is constructed. The scale provides a countable linearly ordered set of measures of independence.
Students' Misconceptions about Random Variables
Kachapova, Farida; Kachapov, Ilias
2012-01-01
This article describes some misconceptions about random variables and related counter-examples, and makes suggestions about teaching initial topics on random variables in general form instead of doing it separately for discrete and continuous cases. The focus is on post-calculus probability courses. (Contains 2 figures.)
Symmetrization of binary random variables
Kagan, Abram; Mallows, Colin L.; Shepp, Larry A.; Vanderbei, Robert J.; Vardi, Yehuda
1999-01-01
A random variable [math] is called an independent symmetrizer of a given random variable [math] if (a) it is independent of [math] and (b) the distribution of [math] is symmetric about [math] . In cases where the distribution of [math] is symmetric about its mean, it is easy to see that the constant random variable [math] is a minimum-variance independent symmetrizer. Taking [math] to have the same distribution as [math] clearly produces a symmetric sum, but it may not be of minimum variance....
Complete Convergence for Weighted Sums of WOD Random Variables
Institute of Scientific and Technical Information of China (English)
ZHANG Ying; ZHANG Yu; SHEN Ai-ting
2016-01-01
In this article, we study the complete convergence for weighted sums of widely orthant dependent random variables. By using the exponential probability inequality, we establish a complete convergence result for weighted sums of widely orthant dependent ran-dom variables under mild conditions of weights and moments. The result obtained in the paper generalizes the corresponding ones for independent random variables and negatively dependent random variables.
On Sums of Conditionally Independent Subexponential Random Variables
Foss, Serguei; Richards, Andrew
2008-01-01
The asymptotic tail behaviour of sums of independent subexponential random variables is well understood, one of the main characteristics being the principle of the single big jump. We study the case of dependent subexponential random variables, for both deterministic and random sums, using a fresh approach, by considering conditional independence structures on the random variables. We seek sufficient conditions for the results of the theory with independent random variables still to hold. For...
Contextuality is about identity of random variables
International Nuclear Information System (INIS)
Contextual situations are those in which seemingly ‘the same’ random variable changes its identity depending on the conditions under which it is recorded. Such a change of identity is observed whenever the assumption that the variable is one and the same under different conditions leads to contradictions when one considers its joint distribution with other random variables (this is the essence of all Bell-type theorems). In our Contextuality-by-Default approach, instead of asking why or how the conditions force ‘one and the same’ random variable to change ‘its’ identity, any two random variables recorded under different conditions are considered different ‘automatically.’ They are never the same, nor are they jointly distributed, but one can always impose on them a joint distribution (probabilistic coupling). The special situations when there is a coupling in which these random variables are equal with probability 1 are considered noncontextual. Contextuality means that such couplings do not exist. We argue that the determination of the identity of random variables by conditions under which they are recorded is not a causal relationship and cannot violate laws of physics. (paper)
Contextuality is about identity of random variables
Dzhafarov, Ehtibar N.; Kujala, Janne V.
2014-12-01
Contextual situations are those in which seemingly ‘the same’ random variable changes its identity depending on the conditions under which it is recorded. Such a change of identity is observed whenever the assumption that the variable is one and the same under different conditions leads to contradictions when one considers its joint distribution with other random variables (this is the essence of all Bell-type theorems). In our Contextuality-by-Default approach, instead of asking why or how the conditions force ‘one and the same’ random variable to change ‘its’ identity, any two random variables recorded under different conditions are considered different ‘automatically.’ They are never the same, nor are they jointly distributed, but one can always impose on them a joint distribution (probabilistic coupling). The special situations when there is a coupling in which these random variables are equal with probability 1 are considered noncontextual. Contextuality means that such couplings do not exist. We argue that the determination of the identity of random variables by conditions under which they are recorded is not a causal relationship and cannot violate laws of physics.
RANDOM VARIABLE WITH FUZZY PROBABILITY
Institute of Scientific and Technical Information of China (English)
吕恩琳; 钟佑明
2003-01-01
Mathematic description about the second kind fuzzy random variable namely the random variable with crisp event-fuzzy probability was studied. Based on the interval probability and using the fuzzy resolution theorem, the feasible condition about a probability fuzzy number set was given, go a step further the definition arid characters of random variable with fuzzy probability ( RVFP ) and the fuzzy distribution function and fuzzy probability distribution sequence of the RVFP were put forward. The fuzzy probability resolution theorem with the closing operation of fuzzy probability was given and proved. The definition and characters of mathematical expectation and variance of the RVFP were studied also. All mathematic description about the RVFP has the closing operation for fuzzy probability, as a result, the foundation of perfecting fuzzy probability operation method is laid.
A Measure of Monotonicity of two Random Variables
Ilias Kachapov; Farida Kachapova
2012-01-01
Problem statement: When analyzing random variables it was useful to measure the degree of their monotone dependence or compare pairs of random variables with respect to their monotonicity. Existing coefficients measure general or linear dependence of random variables. Developing a measure of monotonicity was useful for practical applications as well as for general theory, since monotonicity was an important type of dependence. Approach: Existing measures of dependence are briefly reviewed. Th...
Institute of Scientific and Technical Information of China (English)
De Mei YUAN; Jun AN
2012-01-01
Both residual Cesàro alpha-integrability (RCI(α)) and strongly residual Cesàro alphaintegrability (SRCI(α)) are two special kinds of extensions to uniform integrability,and both asymptotically almost negative association (AANA) and asymptotically quadrant sub-independence (AQSI)are two special kinds of dependence structures.By relating the RCI(α) property as well as the SRCI(α)property with dependence condition AANA or AQSI,we formulate some tail-integrability conditions under which for appropriate α the RCI(α) property yields L1-convergence results and the SRCI(α)property yields strong laws of large numbers,which is the continuation of the corresponding literature.
Randomness and Earth climate variability
Levinshtein, Michael E; Dmitriev, Alexander P; Shmakov, Pavel M
2015-01-01
Paleo-Sciences including palaeoclimatology and palaeoecology have accumulated numerous records related to climatic changes. The researchers have usually tried to identify periodic and quasi-periodic processes in these paleoscientific records. In this paper, we show that this analysis is incomplete. As follows from our results, random processes, namely processes with a single-time-constant (noise with a Lorentzian noise spectrum), play a very important and, perhaps, a decisive role in numerous natural phenomena. For several of very important natural phenomena the characteristic time constants are very similar and equal to (5-8)x10^3 years. However, this value is not universal. For example, the spectral density fluctuations of the atmospheric radiocarbon 14C are characterized by a Lorentzian with time constant 300 years. The frequency dependence of spectral density fluctuations for benthic 18O records contains two Lorentzians with time constans 8000 years and > 105 years.
The geometry of proper quaternion random variables
Bihan, Nicolas le
2015-01-01
Properness of a quaternion random variable is related to the symmetries of its probability density function in $4D$ space. Thus, properness should be defined with respect to the most general isometries in $4D$, i.e. rotations from $SO(4)$. Based on this, we propose a new definition of properness, namely the $(\\alpha,\\beta)$-properness, for quaternion random variables using invariance property under the action of the rotation group $SO(4)$. This new definition generalizes previously introduced...
Asymptotics for Associated Random Variables
Oliveira, Paulo Eduardo
2012-01-01
The book concerns the notion of association in probability and statistics. Association and some other positive dependence notions were introduced in 1966 and 1967 but received little attention from the probabilistic and statistics community. The interest in these dependence notions increased in the last 15 to 20 years, and many asymptotic results were proved and improved. Despite this increased interest, characterizations and results remained essentially scattered in the literature published in different journals. The goal of this book is to bring together the bulk of these results, presenting
Delocalization for Random Landau Hamiltonians with Unbounded Random Variables
Germinet, François; Mandy, Benoît
2009-01-01
In this note we prove the existence of a localization/delocalization transition for Landau Hamiltonians randomly perturbed by an electric potential with unbounded amplitude. In particular, with probability one, no Landau gaps survive as the random potential is turned on, the gaps close, filling up partly with localized states. A minimal rate of transport is exhibited in the region of delocalization. To do so, we exploit the a priori quantization of the Hall conductance and extend recent Wegner estimates to the case of unbounded random variables.
Probability Inequalities for Extended Negatively Dep endent Random Variables and Their Applications
Institute of Scientific and Technical Information of China (English)
TANG Xiao-feng
2014-01-01
Some probability inequalities are established for extended negatively dependent (END) random variables. The inequalities extend some corresponding ones for negatively associated random variables and negatively orthant dependent random variables. By using these probability inequalities, we further study the complete convergence for END random variables. We also obtain the convergence rate O(n−1/2 ln1/2 n) for the strong law of large numbers, which generalizes and improves the corresponding ones for some known results.
Polynomial chaos expansion with random and fuzzy variables
Jacquelin, E.; Friswell, M. I.; Adhikari, S.; Dessombz, O.; Sinou, J.-J.
2016-06-01
A dynamical uncertain system is studied in this paper. Two kinds of uncertainties are addressed, where the uncertain parameters are described through random variables and/or fuzzy variables. A general framework is proposed to deal with both kinds of uncertainty using a polynomial chaos expansion (PCE). It is shown that fuzzy variables may be expanded in terms of polynomial chaos when Legendre polynomials are used. The components of the PCE are a solution of an equation that does not depend on the nature of uncertainty. Once this equation is solved, the post-processing of the data gives the moments of the random response when the uncertainties are random or gives the response interval when the variables are fuzzy. With the PCE approach, it is also possible to deal with mixed uncertainty, when some parameters are random and others are fuzzy. The results provide a fuzzy description of the response statistical moments.
Product of n independent uniform random variables
Dettmann, Carl P.; Georgiou, Orestis
2009-01-01
Abstract We give an alternative proof of a useful formula for calculating the probability density function of the product of n uniform, independently and identically distributed random variables. Ishihara (2002, in Japanese) proves the result by induction; here we use Fourier analysis and contour integral methods which provide a more intuitive explanation of how the convolution theorem acts in this case. correspondance: Corresponding author. ...
The random-variable canonical distribution
International Nuclear Information System (INIS)
An alternative interpretation to Gibbs' concept of the canonical distribution for an ensemble of systems in statistical equilibrium is proposed. Whereas Gibbs' theory is based upon a consideration of systems subject to dynamical law, the present analysis relies neither on the classical equations of motion nor makes use of any a priori probability of a complexion; rather, it makes avail of the basic algebra of random variables and, specifically, invokes the law of large numbers. Thereby, a canonical distribution is derived which describes a macrosystem in probabilistic, rather than deterministic, terms, and facilitates the understanding of energy fluctuations which occur in macrosystems at an overall constant ensemble temperature. A discussion is given of a modified form of the Gibbs canonical distribution which takes full account of the effects of random energy fluctuations. It is demonstrated that the results from this modified analysis are entirely consonant with those derived from the random-variable approach. (author)
LARGE DEVIATIONS AND MODERATE DEVIATIONS FOR m-NEGATIVELY ASSOCIATED RANDOM VARIABLES
Institute of Scientific and Technical Information of China (English)
Hu Yijun; Ming Ruixing; Yang Wenquan
2007-01-01
M-negatively associated random variables, which generalizes the classical one of negatively associated random variables and includes m-dependent sequences as its particular case, are introduced and studied. Large deviation principles and moderate deviation upper bounds for stationary m-negatively associated random variables are proved.Kolmogorov-type and Marcinkiewicz-type strong laws of large numbers as well as the three series theorem for m-negatively associated random variables are also given.
Inequalities for Walsh like random variables
D. Hajela
1990-01-01
Let (Xn)nÃ¢Â‰Â¥1 be a sequence of mean zero independent random variables. Let Wk={Ã¢ÂˆÂj=1kXij|1Ã¢Â‰Â¤i10 and let C(p,m)=16(52p2pÃ¢ÂˆÂ’1)mÃ¢ÂˆÂ’1plogp(KÃŽÂ´)m for 1
Lr Convergence for Arrays of Rowwise Negatively Sup eradditive Dep endent Random Variables
Institute of Scientific and Technical Information of China (English)
ZHU Hua-yan; SHEN Ai-ting; ZHANG Ying
2016-01-01
Let {Xnk, k≥1, n≥1} be an array of rowwise negatively superadditive depen-dent random variables and {an, n ≥ 1} be a sequence of positive real numbers such that an ↑ ∞. Under some suitable conditions, Lr convergence of a1n 1max≤j≤n ied. The results obtained in this paper generalize and improve some corresponding ones for negatively associated random variables and independent random variables. fl fl fl fl jP k=1 Xnk fl fl flfl is stud-ied. The results obtained in this paper generalize and improve some corresponding ones for negatively associated random variables and independent random variables.
Strong Laws of Large Numbers for Arrays of Rowwise NA and LNQD Random Variables
Directory of Open Access Journals (Sweden)
Jiangfeng Wang
2011-01-01
Full Text Available Some strong laws of large numbers and strong convergence properties for arrays of rowwise negatively associated and linearly negative quadrant dependent random variables are obtained. The results obtained not only generalize the result of Hu and Taylor to negatively associated and linearly negative quadrant dependent random variables, but also improve it.
Probabilistic norms and statistical convergence of random variables
Directory of Open Access Journals (Sweden)
Mohamad Rafi Segi Rahmat
2009-03-01
Full Text Available The paper extends certain stochastic convergence of sequences of Rk -valued random variables (namely, the convergence in probability, in Lp and almost surely to the context of E-valued random variables.
Summability of Double Independent Random Variables
Ekrem Savaş; Richard F. Patterson
2008-01-01
We will examine double sequence to double sequence transformation of independent identically distribution random variables with respect to four-dimensional summability matrix methods. The main goal of this paper is the presentation of the following theorem. If maxÃ¢ÂÂ¡k,l|am,n,k,l|=maxÃ¢ÂÂ¡k,l|am,kan,l|=O(mÃ¢ÂˆÂ’ÃŽÂ³1)O(nÃ¢ÂˆÂ’ÃŽÂ³2), ÃŽÂ³1,ÃŽÂ³2>0, then E|XÃ¢ÂŒÂ£|1+1/ÃŽÂ³1
Almost Sure Convergence Theorem and Strong Stability for Weighted Sums of NSD Random Variables
Institute of Scientific and Technical Information of China (English)
Yan SHEN; Xue Jun WANG; Wen Zhi YANG; Shu He HU
2013-01-01
In this paper,Kolmogorov-type inequality for negatively superadditive dependent (NSD)random variables is established.By using this inequality,we obtain the almost sure convergence for NSD sequences,which extends the corresponding results for independent sequences and negatively associated (NA) sequences.In addition,the strong stability for weighted sums of NSD random variables is studied.
Summability of Double Independent Random Variables
Directory of Open Access Journals (Sweden)
Ekrem Savaş
2008-09-01
Full Text Available We will examine double sequence to double sequence transformation of independent identically distribution random variables with respect to four-dimensional summability matrix methods. The main goal of this paper is the presentation of the following theorem. If maxÃ¢ÂÂ¡k,l|am,n,k,l|=maxÃ¢ÂÂ¡k,l|am,kan,l|=O(mÃ¢ÂˆÂ’ÃŽÂ³1O(nÃ¢ÂˆÂ’ÃŽÂ³2, ÃŽÂ³1,ÃŽÂ³2>0, then E|XÃ¢ÂŒÂ£|1+1/ÃŽÂ³1<Ã¢ÂˆÂž and E|XÃ¢ÂŒÂ£Ã¢ÂŒÂ£|1+1/ÃŽÂ³2<Ã¢ÂˆÂž imply that Ym,nÃ¢Â†Â’ÃŽÂ¼ almost sure P-convergence.
Probability, random variables, and random processes theory and signal processing applications
Shynk, John J
2012-01-01
Probability, Random Variables, and Random Processes is a comprehensive textbook on probability theory for engineers that provides a more rigorous mathematical framework than is usually encountered in undergraduate courses. It is intended for first-year graduate students who have some familiarity with probability and random variables, though not necessarily of random processes and systems that operate on random signals. It is also appropriate for advanced undergraduate students who have a strong mathematical background. The book has the following features: Several app
PROBABILITY INEQUALITIES FOR SUMS OF INDEPENDENT UNBOUNDED RANDOM VARIABLES
Institute of Scientific and Technical Information of China (English)
张涤新; 王志诚
2001-01-01
The tail probability inequalities for the sum of independent unbounded random variables on a probability space ( Ω , T, P) were studied and a new method was proposed to treat the sum of independent unbounded random variables by truncating the original probability space (Ω, T, P ). The probability exponential inequalities for sums of independent unbounded random variables were given. As applications of the results, some interesting examples were given. The examples show that the method proposed in the paper and the results of the paper are quite useful in the study of the large sample properties of the sums of independent unbounded random variables.
Environment-dependent continuous time random walk
Institute of Scientific and Technical Information of China (English)
Lin Fang; Bao Jing-Dong
2011-01-01
A generalized continuous time random walk model which is dependent on environmental damping is proposed in which the two key parameters of the usual random walk theory:the jumping distance and the waiting time, are replaced by two new ones:the pulse velocity and the flight time. The anomalous diffusion of a free particle which is characterized by the asymptotical mean square displacement ～tα is realized numerically and analysed theoretically, where the value of the power index a is in a region of 0<α<2. Particularly, the damping leads to a sub-diffusion when the impact velocities are drawn from a Gaussian density function and the super-diffusive effect is related to statistical extremes, which are called rare-though-dominant events.
Cardinality-dependent Variability in Orthogonal Variability Models
DEFF Research Database (Denmark)
Mærsk-Møller, Hans Martin; Jørgensen, Bo Nørregaard
2012-01-01
During our work on developing and running a software product line for eco-sustainable greenhouse-production software tools, which currently have three products members we have identified a need for extending the notation of the Orthogonal Variability Model (OVM) to support what we refer to as...... cardinality range dependencies. The cardinality-range-dependency type enables expressing that the binding of a certain number of variants to a variation point can influence variability in other places in the model. In other words, we acknowledge that variability can be influenced, not necessarily by the...
Moment inequalities for the partial sums of random variables
Institute of Scientific and Technical Information of China (English)
杨善朝
2001-01-01
This paper discusses the conditions under which Rosenthal type inequality is obtained from M-Z-B type inequality. And M-Z-B type inequality is proved for a wide class of random variables. Hence Rosenthal type inequalities for some classes of random variables are obtained.
An Inequality for the Sum of Independent Bounded Random Variables
Dance, Christopher R.
2012-01-01
We give a simple inequality for the sum of independent bounded random variables. This inequality improves on the celebrated result of Hoeffding in a special case. It is optimal in the limit where the sum tends to a Poisson random variable.
Quantifying Redundant Information in Predicting a Target Random Variable
Directory of Open Access Journals (Sweden)
Virgil Griffith
2015-07-01
Full Text Available We consider the problem of defining a measure of redundant information that quantifies how much common information two or more random variables specify about a target random variable. We discussed desired properties of such a measure, and propose new measures with some desirable properties.
On the product and ratio of Bessel random variables
Directory of Open Access Journals (Sweden)
Saralees Nadarajah
2005-01-01
Full Text Available The distributions of products and ratios of random variables are of interest in many areas of the sciences. In this paper, the exact distributions of the product |XY| and the ratio |X/Y| are derived when X and Y are independent Bessel function random variables. An application of the results is provided by tabulating the associated percentage points.
Communication Requirements for Generating Correlated Random Variables
Cuff, Paul
2008-01-01
Two familiar notions of correlation are rediscovered as extreme operating points for simulating a discrete memoryless channel, in which a channel output is generated based only on a description of the channel input. Wyner's "common information" coincides with the minimum description rate needed. However, when common randomness independent of the input is available, the necessary description rate reduces to Shannon's mutual information. This work characterizes the optimal tradeoff between the amount of common randomness used and the required rate of description.
On the minimum of independent geometrically distributed random variables
Ciardo, Gianfranco; Leemis, Lawrence M.; Nicol, David
1994-01-01
The expectations E(X(sub 1)), E(Z(sub 1)), and E(Y(sub 1)) of the minimum of n independent geometric, modifies geometric, or exponential random variables with matching expectations differ. We show how this is accounted for by stochastic variability and how E(X(sub 1))/E(Y(sub 1)) equals the expected number of ties at the minimum for the geometric random variables. We then introduce the 'shifted geometric distribution' and show that there is a unique value of the shift for which the individual shifted geometric and exponential random variables match expectations both individually and in the minimums.
Central limit theorem for a class of globally correlated random variables
Budini, Adrián A.
2016-06-01
The standard central limit theorem with a Gaussian attractor for the sum of independent random variables may lose its validity in the presence of strong correlations between the added random contributions. Here, we study this problem for similar interchangeable globally correlated random variables. Under these conditions, a hierarchical set of equations is derived for the conditional transition probabilities. This result allows us to define different classes of memory mechanisms that depend on a symmetric way on all involved variables. Depending on the correlation mechanisms and statistics of the single variables, the corresponding sums are characterized by distinct probability densities. For a class of urn models it is also possible to characterize their domain of attraction, which, as in the standard case, is parametrized by the probability density of each random variable. Symmetric and asymmetric q -Gaussian attractors (q <1 ) arise in a particular two-state case of these urn models.
Randomly weighted sums of subexponential random variables with application to ruin theory
Q. Tang; G. Tsitsiashvili
2003-01-01
Let {X k , 1 k n} be n independent and real-valued random variables with common subexponential distribution function, and let {k, 1 k n} be other n random variables independent of {X k , 1 k n} and satisfying a k b for some 0 < a b < for all 1 k n. This paper proves that the asymptotic relations P (
Institute of Scientific and Technical Information of China (English)
刘艳; 胡亦钧
2003-01-01
We prove large deviation results on the partial and random sums Sn = ∑ni=1 Xi, n≥1; S(t) =∑N(t)i=1 Xi, t≥0, where {N(t);t≥0} are non-negative integer-valued random variables and {Xn;n≥1} areindependent non-negative random variables with distribution, Fn, of Xn, independent of {N(t); t≥0}. Specialattention is paid to the distribution of dominated variation.
Limiting Behavior of Weighted Sums of NOD Random Variables
Institute of Scientific and Technical Information of China (English)
De Hua QIU; Ping Yan CHEN
2011-01-01
The strong laws of large numbers and laws of the single logarithm for weighted sums of NOD random variables are established.The results presented generalize the corresponding results of Chen and Gan [5]in independent sequence case.
Designing neural networks that process mean values of random variables
International Nuclear Information System (INIS)
We develop a class of neural networks derived from probabilistic models posed in the form of Bayesian networks. Making biologically and technically plausible assumptions about the nature of the probabilistic models to be represented in the networks, we derive neural networks exhibiting standard dynamics that require no training to determine the synaptic weights, that perform accurate calculation of the mean values of the relevant random variables, that can pool multiple sources of evidence, and that deal appropriately with ambivalent, inconsistent, or contradictory evidence. - Highlights: • High-level neural computations are specified by Bayesian belief networks of random variables. • Probability densities of random variables are encoded in activities of populations of neurons. • Top-down algorithm generates specific neural network implementation of given computation. • Resulting “neural belief networks” process mean values of random variables. • Such networks pool multiple sources of evidence and deal properly with inconsistent evidence
Random Forests for Ordinal Response Data: Prediction and Variable Selection
Janitza, Silke; Tutz, Gerhard; Boulesteix, Anne-Laure
2014-01-01
The random forest method is a commonly used tool for classification with high-dimensional data that is able to rank candidate predictors through its inbuilt variable importance measures (VIMs). It can be applied to various kinds of regression problems including nominal, metric and survival response variables. While classification and regression problems using random forest methodology have been extensively investigated in the past, there seems to be a lack of literature on handling ordinal re...
Exponential Inequalities for Positively Associated Random Variables and Applications
Directory of Open Access Journals (Sweden)
Yang Shanchao
2008-01-01
Full Text Available Abstract We establish some exponential inequalities for positively associated random variables without the boundedness assumption. These inequalities improve the corresponding results obtained by Oliveira (2005. By one of the inequalities, we obtain the convergence rate for the case of geometrically decreasing covariances, which closes to the optimal achievable convergence rate for independent random variables under the Hartman-Wintner law of the iterated logarithm and improves the convergence rate derived by Oliveira (2005 for the above case.
Some Limit Theorems for Negatively Associated Random Variables
Indian Academy of Sciences (India)
Yu Miao; Wenfei Xu; Shanshan Chen; Andre Adler
2014-08-01
Let $\\{X_n,n≥ 1\\}$ be a sequence of negatively associated random variables. The aim of this paper is to establish some limit theorems of negatively associated sequence, which include the $L^p$-convergence theorem and Marcinkiewicz–Zygmund strong law of large numbers. Furthermore, we consider the strong law of sums of order statistics, which are sampled from negatively associated random variables.
Problems Identifying Independent and Dependent Variables
Leatham, Keith R.
2012-01-01
This paper discusses one step from the scientific method--that of identifying independent and dependent variables--from both scientific and mathematical perspectives. It begins by analyzing an episode from a middle school mathematics classroom that illustrates the need for students and teachers alike to develop a robust understanding of…
PaCAL: A Python Package for Arithmetic Computations with Random Variables
Directory of Open Access Journals (Sweden)
Marcin Korze?
2014-05-01
Full Text Available In this paper we present PaCAL, a Python package for arithmetical computations on random variables. The package is capable of performing the four arithmetic operations: addition, subtraction, multiplication and division, as well as computing many standard functions of random variables. Summary statistics, random number generation, plots, and histograms of the resulting distributions can easily be obtained and distribution parameter ?tting is also available. The operations are performed numerically and their results interpolated allowing for arbitrary arithmetic operations on random variables following practically any probability distribution encountered in practice. The package is easy to use, as operations on random variables are performed just as they are on standard Python variables. Independence of random variables is, by default, assumed on each step but some computations on dependent random variables are also possible. We demonstrate on several examples that the results are very accurate, often close to machine precision. Practical applications include statistics, physical measurements or estimation of error distributions in scienti?c computations.
New Results On the Sum of Two Generalized Gaussian Random Variables
Soury, Hamza
2015-01-01
We propose in this paper a new method to compute the characteristic function (CF) of generalized Gaussian (GG) random variable in terms of the Fox H function. The CF of the sum of two independent GG random variables is then deduced. Based on this results, the probability density function (PDF) and the cumulative distribution function (CDF) of the sum distribution are obtained. These functions are expressed in terms of the bivariate Fox H function. Next, the statistics of the distribution of the sum, such as the moments, the cumulant, and the kurtosis, are analyzed and computed. Due to the complexity of bivariate Fox H function, a solution to reduce such complexity is to approximate the sum of two independent GG random variables by one GG random variable with suitable shape factor. The approximation method depends on the utility of the system so three methods of estimate the shape factor are studied and presented.
Applying Free Random Variables to Random Matrix Analysis of Financial Data
Burda, Z; Jurkiewicz, J; Nowak, M A; Papp, G; Zahed, I
2006-01-01
We apply the concept of free random variables to correlated Wishart random matrix models. We give a comprehensive rederivation of various spectral densities for a number of financial covariance matrices involving stocks returns without and with exponentially weighted moving averages. We show through simple models how to identify the pertinent underlying correlations. We extend our results to Levy-Wishart random matrix models whereby the risk factors are heavy tailed.
A Random Variable Related to the Inversion Vector of a Partial Random Permutation
Laghate, Kavita; Deshpande, M. N.
2005-01-01
In this article, we define the inversion vector of a permutation of the integers 1, 2,..., n. We set up a particular kind of permutation, called a partial random permutation. The sum of the elements of the inversion vector of such a permutation is a random variable of interest.
Random Time Dependent Resistance Analysis on Reinforced Concrete Structures
Institute of Scientific and Technical Information of China (English)
GUAN Chang-sheng; WU Ling
2002-01-01
The analysis method on random time dependence of reinforced concrete material is introduced,the effect mechanism on reinforced concrete are discussed, and the random time dependence resistance of reinforced concrete is studied. Furthermore, the corrosion of steel bar in reinforced concrete structures is analyzed. A practical statistical method of evaluating the random time dependent resistance, which includes material, structural size and calculation influence, is also established. In addition, an example of predicting random time dependent resistance of reinforced concrete structural element is given.
Age-dependent branching processes in random environments
Institute of Scientific and Technical Information of China (English)
2008-01-01
We consider an age-dependent branching process in random environments. The environments are represented by a stationary and ergodic sequence ξ = (ξ0,ξ1,...) of random variables. Given an environment ξ, the process is a non-homogenous Galton-Watson process, whose particles in n-th generation have a life length distribution G(ξn) on R+, and reproduce independently new particles according to a probability law p(ξn) on N. Let Z(t) be the number of particles alive at time t. We first find a characterization of the conditional probability generating function of Z(t) (given the environment ξ) via a functional equation, and obtain a criterion for almost certain extinction of the process by comparing it with an embedded Galton-Watson process. We then get expressions of the conditional mean EξZ(t) and the global mean EZ(t), and show their exponential growth rates by studying a renewal equation in random environments.
Discrete Random Contention System with Variable Packet Length
Directory of Open Access Journals (Sweden)
Yingying Guo
2013-07-01
Full Text Available The paper researches the random contention system in-depth using the average cycle method, then gets the formulas of the systemic throughput, free rate and collision rate with variable packet length. The simulation results verify the correctness of the theory, meanwhile, gets some conclusions that the different arrival rate G is how to affect the main source of the throughput with variable packet length. It has some researching significance.
Repeated Sprints: An Independent Not Dependent Variable.
Taylor, Jonathan M; Macpherson, Tom W; Spears, Iain R; Weston, Matthew
2016-07-01
The ability to repeatedly perform sprints has traditionally been viewed as a key performance measure in team sports, and the relationship between repeated-sprint ability (RSA) and performance has been explored extensively. However, when reviewing the repeated-sprint profile of team-sports match play it appears that the occurrence of repeated-sprint bouts is sparse, indicating that RSA is not as important to performance as commonly believed. Repeated sprints are, however, a potent and time-efficient training strategy, effective in developing acceleration, speed, explosive leg power, aerobic power, and high-intensity-running performance--all of which are crucial to team-sport performance. As such, we propose that repeated-sprint exercise in team sports should be viewed as an independent variable (eg, a means of developing fitness) as opposed to a dependent variable (eg, a means of assessing fitness/performance). PMID:27197118
ADORAVA - A computer code to sum random variables
International Nuclear Information System (INIS)
The ADORAVA computer code was carried out aiming to determine the moments of random variable sum distribution when moments are known. The ADORAVA computer code was developed to be applied in probabilistic safety analysis, more specifically for uncertainty propagation in fault trees. The description of ADORAVA algorithm, input, examples and the output of compiled code are presented. (M.C.K.)
Reduction of the Random Variables of the Turbulent Wind Field
DEFF Research Database (Denmark)
Sichani, Mahdi Teimouri; Nielsen, Søren R.K.
Applicability of the Probability Density Evolution Method (PDEM) for realizing evolution of the probability density for the wind turbines has rather strict bounds on the basic number of the random variables involved in the model. The efficiency of most of the Advanced Monte Carlo (AMC) methods, i...
Some Limit Theorems for Weighted Sums of Random Variable Fields
Institute of Scientific and Technical Information of China (English)
无
2006-01-01
Let{X-n,-n∈Nd} be a field of Banach space valued random variables, 0 ＜r＜p≤2 and{a-n,-k,(-n,-k)∈Nd×Nd,-k≤-n} a triangular array of real numbers, where Nd is the d-dimensional lattice(d≥1). Under the minimal condition that {‖X-n‖r,-n∈Nd} is {|a-n,-k|r,(-n,-k)} ∈Nd×Nd,-k≤-n}-uniformly integrable, we show that ∑(-k≤-n)(a-n,-kX-k)Lr(or a.s.)→0 as |-n|→∞. In the above, if 0＜r＜1, the random variables are not needed to be independent. If 1≤r＜p≤2, and Banach space valued random variables are independent with mean zero we assume the Banach space is of type p. If 1≤r＜p≤2 and Banach space valued random variables are not independent we assume the Banach space is p-smoothable.
Gamma distributed random variables and their semi-quantum operators
International Nuclear Information System (INIS)
We first introduce the joint semi-quantum operators of a finite family of random variables having finite moments of all orders. We then use the semi-quantum operators to characterize the one-dimensional Gamma and Gaussian distributions in terms of their commutators
Generation of correlated finite alphabet waveforms using gaussian random variables
Ahmed, Sajid
2016-01-13
Various examples of methods and systems are provided for generation of correlated finite alphabet waveforms using Gaussian random variables in, e.g., radar and communication applications. In one example, a method includes mapping an input signal comprising Gaussian random variables (RVs) onto finite-alphabet non-constant-envelope (FANCE) symbols using a predetermined mapping function, and transmitting FANCE waveforms through a uniform linear array of antenna elements to obtain a corresponding beampattern. The FANCE waveforms can be based upon the mapping of the Gaussian RVs onto the FANCE symbols. In another example, a system includes a memory unit that can store a plurality of digital bit streams corresponding to FANCE symbols and a front end unit that can transmit FANCE waveforms through a uniform linear array of antenna elements to obtain a corresponding beampattern. The system can include a processing unit that can encode the input signal and/or determine the mapping function.
Random variability explains apparent global clustering of large earthquakes
Michael, A.J.
2011-01-01
The occurrence of 5 Mw ≥ 8.5 earthquakes since 2004 has created a debate over whether or not we are in a global cluster of large earthquakes, temporarily raising risks above long-term levels. I use three classes of statistical tests to determine if the record of M ≥ 7 earthquakes since 1900 can reject a null hypothesis of independent random events with a constant rate plus localized aftershock sequences. The data cannot reject this null hypothesis. Thus, the temporal distribution of large global earthquakes is well-described by a random process, plus localized aftershocks, and apparent clustering is due to random variability. Therefore the risk of future events has not increased, except within ongoing aftershock sequences, and should be estimated from the longest possible record of events.
Problems of variance reduction in the simulation of random variables
International Nuclear Information System (INIS)
The definition of the uniform linear generator is given and some of the mostly used tests to evaluate the uniformity and the independence of the obtained determinations are listed. The problem of calculating, through simulation, some moment W of a random variable function is taken into account. The Monte Carlo method enables the moment W to be estimated and the estimator variance to be obtained. Some techniques for the construction of other estimators of W with a reduced variance are introduced
Entropy power inequality for a family of discrete random variables
Sharma, Naresh; Muthukrishnan, Siddharth
2010-01-01
It is known that the Entropy Power Inequality (EPI) always holds if the random variables have density. Not much work has been done to identify discrete distributions for which the inequality holds with the differential entropy replaced by the discrete entropy. Harremo\\"{e}s and Vignat showed that it holds for the pair (B(m,p), B(n,p)), m,n \\in \\mathbb{N}, (where B(n,p) is a Binomial distribution with n trials each with success probability p) for p = 0.5. In this paper, we considerably expand the set of Binomial distributions for which the inequality holds and, in particular, identify n_0(p) such that for all m,n \\geq n_0(p), the EPI holds for (B(m,p), B(n,p)). We further show that the EPI holds for the discrete random variables that can be expressed as the sum of n independent identical distributed (IID) discrete random variables for large n.
A Stepwise Approach of Finding Dependent Variables via Coefficient of Intrinsic Dependence.
Hsiao, Ya-Chun; Liu, Li-Yu Daisy
2016-01-01
The coefficient of intrinsic dependence (CID) is capable of determining associations among variables without making distributional or functional assumptions regarding random variables. In this study, we developed the partial coefficient of intrinsic dependence (pCID) to facilitate the step-by-step selection of variables that are relevant to a target variable. The strategy of selecting relevant variables using the CID along with the pCID can eliminate interference from other relevant variables. From simulation results, we observed that the proposed method is more sensitive to curvilinearity and more specific to linearity than the combination of Pearsons correlation coefficient and the partial correlation coefficient (PCC/pPCC). This property may provide the opportunity to index different levels of curvilinearity according to CID/pCID outcomes. In practice trials conducted using publicly available microarray data, the CID/pCID procedure successfully identified cold-responsive genes related to three C-repeat binding factors, and was especially effective at identifying some sample-specific gene-gene interactions. Therefore, the proposed strategy may be beneficial in meta-analysis to distinguish general forms of relationships from the noise. PMID:26645623
On the behavior of the product of independent random variables
Institute of Scientific and Technical Information of China (English)
无
2006-01-01
For two independent non-negative random variables X and Y, we treat X as the initial variable of major importance and Y as a modifier (such as the interest rate of a portfolio).Stability in the tail behaviors of the product compared with that of the original variable X is of practical interests. In this paper, we study the tail behaviors of the product XY when the distribution of X belongs to the classes L and S, respectively. Under appropriate conditions, we show that the distribution of the product XY is in the same class as X when X belongs to class L or S, in other words, classes L and S are stable under some mild conditions on the distribution of Y. We also show that if the distribution of X is in class L(γ) (γ＞ 0) and continuous, then the product XY is in L if and only if Y is unbounded.
Partial summations of stationary sequences of non-Gaussian random variables
DEFF Research Database (Denmark)
Mohr, Gunnar; Ditlevsen, Ove Dalager
1996-01-01
The distribution of the sum of a finite number of identically distributed random variables is in many cases easily determined given that the variables are independent. The moments of any order of the sum can always be expressed by the moments of the single term without computational problems...... lognormal variables or polynomials of standard Gaussian variables. The dependency structure is induced by specifying the autocorrelation structure of the sequence of standard Gaussian variables. Particularly useful polynomials are the Winterstein approximations that distributionally fit with non......-Gaussian variables up to the moments of the fourth order [Winterstein, S. R. Nonlinear vibration models for extremes and fatigue. J. Engng Mech. ASCE 114 (1988) 1772-1790](1). A method to obtain the Winterstein approximation to a partial sum of a sequence of Winterstein approximations is explained and results are...
Moderate Deviations for Random Sums of Heavy-Tailed Random Variables
Institute of Scientific and Technical Information of China (English)
Fu Qing GAO
2007-01-01
Let{Xn ;n ≥ 1}be a sequence of independent non-negative random variables with commondistribution function F having extended regularly varying tail and finite mean μ = E(X1) and let{N(t);t≥0}be a random process taking non-negative integer values with finite mean λ(t) = E(N(t))x) uniformly for x ∈[γb(t),∞) are obtained,where γ 0 and b(t) can be taken to be a positive functionwith lim t→∞ b(t)/λ(t) = 0.
Casabán, M.-C.; Cortés, J.-C.; Romero, J.-V.; Roselló, M.-D.
2015-07-01
This paper presents a full probabilistic description of the solution of random SI-type epidemiological models which are based on nonlinear differential equations. This description consists of determining: the first probability density function of the solution in terms of the density functions of the diffusion coefficient and the initial condition, which are assumed to be independent random variables; the expectation and variance functions of the solution as well as confidence intervals and, finally, the distribution of time until a given proportion of susceptibles remains in the population. The obtained formulas are general since they are valid regardless the probability distributions assigned to the random inputs. We also present a pair of illustrative examples including in one of them the application of the theoretical results to model the diffusion of a technology using real data.
Moment Estimation Inequalities Based on gλ Random Variable on Sugeno Measure Space
Jingfeng Tian; Zhiming Zhang; Dazeng Tian
2010-01-01
The definitions and properties of moment of gλ random variable are provided on Sugeno measure space. Then some important moment estimation inequalities based on gλ random variable are presented and proven.
Generation of correlated finite alphabet waveforms using gaussian random variables
Jardak, Seifallah
2014-09-01
Correlated waveforms have a number of applications in different fields, such as radar and communication. It is very easy to generate correlated waveforms using infinite alphabets, but for some of the applications, it is very challenging to use them in practice. Moreover, to generate infinite alphabet constant envelope correlated waveforms, the available research uses iterative algorithms, which are computationally very expensive. In this work, we propose simple novel methods to generate correlated waveforms using finite alphabet constant and non-constant-envelope symbols. To generate finite alphabet waveforms, the proposed method map the Gaussian random variables onto the phase-shift-keying, pulse-amplitude, and quadrature-amplitude modulation schemes. For such mapping, the probability-density-function of Gaussian random variables is divided into M regions, where M is the number of alphabets in the corresponding modulation scheme. By exploiting the mapping function, the relationship between the cross-correlation of Gaussian and finite alphabet symbols is derived. To generate equiprobable symbols, the area of each region is kept same. If the requirement is to have each symbol with its own unique probability, the proposed scheme allows us that as well. Although, the proposed scheme is general, the main focus of this paper is to generate finite alphabet waveforms for multiple-input multiple-output radar, where correlated waveforms are used to achieve desired beampatterns. © 2014 IEEE.
Analysis of Secret Key Randomness Exploiting the Radio Channel Variability
Directory of Open Access Journals (Sweden)
Taghrid Mazloum
2015-01-01
Full Text Available A few years ago, physical layer based techniques have started to be considered as a way to improve security in wireless communications. A well known problem is the management of ciphering keys, both regarding the generation and distribution of these keys. A way to alleviate such difficulties is to use a common source of randomness for the legitimate terminals, not accessible to an eavesdropper. This is the case of the fading propagation channel, when exact or approximate reciprocity applies. Although this principle has been known for long, not so many works have evaluated the effect of radio channel properties in practical environments on the degree of randomness of the generated keys. To this end, we here investigate indoor radio channel measurements in different environments and settings at either 2.4625 GHz or 5.4 GHz band, of particular interest for WIFI related standards. Key bits are extracted by quantizing the complex channel coefficients and their randomness is evaluated using the NIST test suite. We then look at the impact of the carrier frequency, the channel variability in the space, time, and frequency degrees of freedom used to construct a long secret key, in relation to the nature of the radio environment such as the LOS/NLOS character.
Strong Law of Large Numb ers for Array of Rowwise AANA Random Variables
Institute of Scientific and Technical Information of China (English)
CHEN Zhi-yong; LIU Ting-ting; WANG Xue-jun; LI Xiao-qin
2014-01-01
In this article, the strong laws of large numbers for array of rowwise asymptot-ically almost negatively associated(AANA) random variables are studied. Some suﬃcient conditions for strong laws of large numbers for array of rowwise AANA random variables are presented without assumption of identical distribution. Our results extend the corresponding ones for independent random variables to case of AANA random variables.
Frequency dependent polarization variability of AGN
Czech Academy of Sciences Publication Activity Database
Bao, G.; Wiita, P. J.; Hadrava, Petr
San Francisco : Astronomical Society of the Pacific, 1996 - (Miller, H.; Webb, J.; Noble, J.), s. 150-155 - (ASP Conference series.. 110). [Blazar Continuum Variability . Miami (US), 04.02.1996-07.02.1996
Separation of Variable Treatment for Solving Time—Dependent Potentials
Institute of Scientific and Technical Information of China (English)
QIANShang－Wu; GUZhi－Yu; 等
2001-01-01
We use the separation of variable treatment to treat some time-dependent systems,and point out that the condition of separability is the same as the condition of existence of invariant,and the separation of variable treatment is interrelated with the quantum-invariant method and the propagator method.We directly use the separation of variable treatment to obtain the wavefunctions of the time-dependent Coulomb potential and the time-dependent Hulthen potential.
Generating Correlated QPSK Waveforms By Exploiting Real Gaussian Random Variables
Jardak, Seifallah
2012-11-01
The design of waveforms with specified auto- and cross-correlation properties has a number of applications in multiple-input multiple-output (MIMO) radar, one of them is the desired transmit beampattern design. In this work, an algorithm is proposed to generate quadrature phase shift- keying (QPSK) waveforms with required cross-correlation properties using real Gaussian random-variables (RV’s). This work can be considered as the extension of what was presented in [1] to generate BPSK waveforms. This work will be extended for the generation of correlated higher-order phase shift-keying (PSK) and quadrature amplitude modulation (QAM) schemes that can better approximate the desired beampattern.
Automatic Probabilistic Program Verification through Random Variable Abstraction
Barsotti, Damián; 10.4204/EPTCS.28.3
2010-01-01
The weakest pre-expectation calculus has been proved to be a mature theory to analyze quantitative properties of probabilistic and nondeterministic programs. We present an automatic method for proving quantitative linear properties on any denumerable state space using iterative backwards fixed point calculation in the general framework of abstract interpretation. In order to accomplish this task we present the technique of random variable abstraction (RVA) and we also postulate a sufficient condition to achieve exact fixed point computation in the abstract domain. The feasibility of our approach is shown with two examples, one obtaining the expected running time of a probabilistic program, and the other the expected gain of a gambling strategy. Our method works on general guarded probabilistic and nondeterministic transition systems instead of plain pGCL programs, allowing us to easily model a wide range of systems including distributed ones and unstructured programs. We present the operational and weakest pr...
Nimon, Kim; Henson, Robin K.
2015-01-01
The authors empirically examined whether the validity of a residualized dependent variable after covariance adjustment is comparable to that of the original variable of interest. When variance of a dependent variable is removed as a result of one or more covariates, the residual variance may not reflect the same meaning. Using the pretest-posttest…
Institute of Scientific and Technical Information of China (English)
刘华汉; 蒋玮; 杨光辉; 吕海霆
2015-01-01
The single mode reliability of the mechanical component is studied with dependent random variables which do not obey the normal distribution.The non-normal distribution random variables are transformed into the normal distribution random variables by using the Rosenblatt transformation (RT),R-F transformation and Edgeworth method.The correlation standard normal random variables are changed into the independent variables on the basis of the linear algebra theory.Then,the single mode reliability index and reliability of mechanical components are obtained by using the first-order second-moment (FOSM)method and advanced first-order second-moment (AFOSM)method.On the basis of the non-normal distribution random variables and the correlation of the variables,computer realization of the reliability calculation algorithm of the mechanical component with single failure mode is proposed.A pair of spur gear in 1 .6 MW wind turbine gearbox is taken as an example with considering one failure mode — tooth surface contact fatigue failure,the effect of the variables' correlation coefficient on the component reliability is analyzed.The high efficiency and applicability of the algorithm are also verified by the example.%研究含有非正态随机变量且随机变量具有相关性的机械零件单模可靠度统一模型，运用 Rosenblatt变换(RT变换)、R-F变换、Edgeworth级数法将非正态分布随机变量变换为正态随机变量，利用线性代数理论将相关标准正态随机变量转换为线性无关的正态随机变量，然后利用一次二阶矩(FOSM)法、改进的一次二阶矩(AFOSM)法求得机械零件单模可靠度指数及可靠度.基于所建机械零件单模可靠度统一模型，提出了含有非正态随机变量且随机变量间具有相关性的零件单模可靠度计算机求解的实现算法.以某1.6 MW风电齿轮箱中一对标准直齿轮啮合传动为例，通过探讨齿面接触疲劳这一单模失效下的可靠度
Warech, E. J.
1967-01-01
Computer program finds values of independent variables which minimize the dependent variable. This optimization program has been used on the F-1 and J-2 engine programs to establish minimum film coolant requirements.
A preliminary, randomized trial of aerobic exercise for alcohol dependence
Brown, Richard A.; Abrantes, Ana M.; Minami, Haruka; Read, Jennifer P.; Marcus, Bess H.; Jakicic, John M.; Strong, David R.; Dubreuil, Mary Ella; Gordon, Alan A.; Ramsey, Susan E.; Kahler, Christopher W.; Stuart, Gregory L.
2014-01-01
Interventions targeting physical activity may be valuable as an adjunct to alcohol treatment, but have been relative untested. In the current study, alcohol dependent, physically sedentary patients were randomized to: a 12-week moderate-intensity, group aerobic exercise intervention (AE; n = 25) or a brief advice to exercise intervention (BA-E; n=23). Results showed that individuals in AE reported significantly fewer drinking and heavy drinking days, relative to BA-E during treatment. Further...
Generalized linear models for categorical and continuous limited dependent variables
Smithson, Michael
2013-01-01
Introduction and OverviewThe Nature of Limited Dependent VariablesOverview of GLMsEstimation Methods and Model EvaluationOrganization of This BookDiscrete VariablesBinary VariablesLogistic RegressionThe Binomial GLMEstimation Methods and IssuesAnalyses in R and StataExercisesNominal Polytomous VariablesMultinomial Logit ModelConditional Logit and Choice ModelsMultinomial Processing Tree ModelsEstimation Methods and Model EvaluationAnalyses in R and StataExercisesOrdinal Categorical VariablesModeling Ordinal Variables: Common Practice versus Best PracticeOrdinal Model AlternativesCumulative Mod
Instrumental variables and Mendelian randomization with invalid instruments
Kang, Hyunseung
Instrumental variables (IV) methods have been widely used to determine the causal effect of a treatment, exposure, policy, or an intervention on an outcome of interest. The IV method relies on having a valid instrument, a variable that is (A1) associated with the exposure, (A2) has no direct effect on the outcome, and (A3) is unrelated to the unmeasured confounders associated with the exposure and the outcome. However, in practice, finding a valid instrument, especially those that satisfy (A2) and (A3), can be challenging. For example, in Mendelian randomization studies where genetic markers are used as instruments, complete knowledge about instruments' validity is equivalent to complete knowledge about the involved genes' functions. The dissertation explores the theory, methods, and application of IV methods when invalid instruments are present. First, when we have multiple candidate instruments, we establish a theoretical bound whereby causal effects are only identified as long as less than 50% of instruments are invalid, without knowing which of the instruments are invalid. We also propose a fast penalized method, called sisVIVE, to estimate the causal effect. We find that sisVIVE outperforms traditional IV methods when invalid instruments are present both in simulation studies as well as in real data analysis. Second, we propose a robust confidence interval under the multiple invalid IV setting. This work is an extension of our work on sisVIVE. However, unlike sisVIVE which is robust to violations of (A2) and (A3), our confidence interval procedure provides honest coverage even if all three assumptions, (A1)-(A3), are violated. Third, we study the single IV setting where the one IV we have may actually be invalid. We propose a nonparametric IV estimation method based on full matching, a technique popular in causal inference for observational data, that leverages observed covariates to make the instrument more valid. We propose an estimator along with
Random recurrence equations and ruin in a Markov-dependent stochastic economic environment
DEFF Research Database (Denmark)
Collamore, Jeffrey F.
2009-01-01
We develop sharp large deviation asymptotics for the probability of ruin in a Markov-dependent stochastic economic environment and study the extremes for some related Markovian processes which arise in financial and insurance mathematics, related to perpetuities and the ARCH(1) and GARCH(1,1) time...... series models. Our results build upon work of Goldie, who has developed tail asymptotics applicable for independent sequences of random variables subject to a random recurrence equation. In contrast, we adopt a general approach based on the theory of Harris recurrent Markov chains and the associated...
Automatic Probabilistic Program Verification through Random Variable Abstraction
Directory of Open Access Journals (Sweden)
Damián Barsotti
2010-06-01
Full Text Available The weakest pre-expectation calculus has been proved to be a mature theory to analyze quantitative properties of probabilistic and nondeterministic programs. We present an automatic method for proving quantitative linear properties on any denumerable state space using iterative backwards fixed point calculation in the general framework of abstract interpretation. In order to accomplish this task we present the technique of random variable abstraction (RVA and we also postulate a sufficient condition to achieve exact fixed point computation in the abstract domain. The feasibility of our approach is shown with two examples, one obtaining the expected running time of a probabilistic program, and the other the expected gain of a gambling strategy. Our method works on general guarded probabilistic and nondeterministic transition systems instead of plain pGCL programs, allowing us to easily model a wide range of systems including distributed ones and unstructured programs. We present the operational and weakest precondition semantics for this programs and prove its equivalence.
Almost Sure Convergence of the General Jamison Weighted Sum of B-Valued Random Variables
Institute of Scientific and Technical Information of China (English)
Chun SU; Tie Jun TONG
2004-01-01
In this paper, two new functions are introduced to depict the Jamison weighted sum of random variables instead using the common methods, their properties and relationships are systematically discussed. We also analysed the implication of the conditions in previous papers. Then we apply these consequences to B-valued random variables, and greatly improve the original results of the strong convergence of the general Jamison weighted sum. Furthermore, our discussions are useful to the corresponding questions of real-valued random variables.
Separation of Variable Treatment for Solving Time-Dependent Potentials
Institute of Scientific and Technical Information of China (English)
QIAN Shang-Wu; GU Zhi-Yu; XIE Guo-Qiang
2001-01-01
We use the separation of variable treatment to treat some time-dependent systems, and point out that the condition of separability is the same as the condition of existence of invariant, and the separation of variable treatment is interrelated with the quantum-invariant method and the propagator method. We directly use the separation of potential.
Gologit2: Generalized Logistic Regression Models for Ordinal Dependent Variables
Richard Williams
2005-01-01
-gologit2- is a user-written program that estimates generalized logistic regression models for ordinal dependent variables. The actual values taken on by the dependent variable are irrelevant except that larger values are assumed to correspond to "higher" outcomes. A major strength of -gologit2- is that it can also estimate two special cases of the generalized model: the proportional odds model and the partial proportional odds model. Hence, -gologit2- can estimate models that are less restri...
Yevdomakha, H. V.; Yu. M. Ivchenko; Skalozub, V. V.; Zhelieznov, K. H.; Litvinov, V. A.; O. P. Ivanov
2004-01-01
The authors propose models and calculation methods for optimal modes of running emu trains, taking into account the random character of catenary voltages and the conditions of dependence of electric power price upon the time of day. The paper suggests criteria for efficient use of variable tariffs and provides examples of calculating the optimal modes of running suburban emu trains.
The dependence of quasar variability on black hole mass
Wold, M; Shang, Z
2006-01-01
In order to investigate the dependence of quasar variability on fundamental physical parameters like black hole mass, we have matched quasars from the QUEST1 Variability Survey with broad-lined objects from the Sloan Digital Sky Survey. The matched sample contains approximately 100 quasars, and the Sloan spectra are used to estimate black hole masses and bolometric luminosities. Variability amplitudes are measured from the QUEST1 light curves. We find that black hole mass correlates with several measures of the variability amplitude at the 99% significance level or better. The correlation does not appear to be caused by obvious selection effects inherent to flux-limited quasar samples, host galaxy contamination or other well-known correlations between quasar variability and luminosity/redshift. We evaluate variability as a function of rest-frame time lag using structure functions, and find further support for the variability--black hole mass correlation. The correlation is strongest for time lags of the order...
Bias in random forest variable importance measures: Illustrations, sources and a solution
Hothorn Torsten; Zeileis Achim; Boulesteix Anne-Laure; Strobl Carolin
2007-01-01
Abstract Background Variable importance measures for random forests have been receiving increased attention as a means of variable selection in many classification tasks in bioinformatics and related scientific fields, for instance to select a subset of genetic markers relevant for the prediction of a certain disease. We show that random forest variable importance measures are a sensible means for variable selection in many applications, but are not reliable in situations where potential pred...
History dependent quantum random walks as quantum lattice gas automata
International Nuclear Information System (INIS)
Quantum Random Walks (QRW) were first defined as one-particle sectors of Quantum Lattice Gas Automata (QLGA). Recently, they have been generalized to include history dependence, either on previous coin (internal, i.e., spin or velocity) states or on previous position states. These models have the goal of studying the transition to classicality, or more generally, changes in the performance of quantum walks in algorithmic applications. We show that several history dependent QRW can be identified as one-particle sectors of QLGA. This provides a unifying conceptual framework for these models in which the extra degrees of freedom required to store the history information arise naturally as geometrical degrees of freedom on the lattice
Explaining the Dark Energy, Baryon and Dark Matter Coincidence via Domain-Dependent Random Densities
McDonald, John
2013-01-01
The dark energy, dark matter and baryon densities in the Universe are observed to be similar, with a factor of no more than 20 between the largest and smallest densities. We show that this coincidence can be understood via superhorizon domains of randomly varying densities when the baryon density at initial collapse of galaxy-forming perturbations is determined by anthropic selection. The baryon and dark matter densities are assumed to be dependent on random variables \\theta_{d} and \\theta_{b} according to \\rho_{dm} ~ \\theta_{d}^{\\alpha} and \\rho_{b} ~ \\theta_{b}^{\\beta}, while the effectively constant dark energy density is dependent upon a random variable \\phi_{Q} according to \\rho_{Q} ~ \\phi_{Q}^{n}. The ratio of the baryon density to the dark energy density at initial collapse, r_{Q}, and the baryon-to-dark matter ratio, r, are then determined purely statistically, with no dependence on the anthropically-preferred baryon density. We compute the probability distribution for r_{Q} and r and show that the ob...
Stable limits for sums of dependent infinite variance random variables
DEFF Research Database (Denmark)
Bartkiewicz, Katarzyna; Jakubowski, Adam; Mikosch, Thomas;
2011-01-01
The aim of this paper is to provide conditions which ensure that the affinely transformed partial sums of a strictly stationary process converge in distribution to an infinite variance stable distribution. Conditions for this convergence to hold are known in the literature. However, most of these...
How fast increasing powers of a continuous random variable converge to Benford's law
Wójcik, Michał Ryszard
2013-01-01
It is known that increasing powers of a continuous random variable converge in distribution to Benford's law as the exponent approaches infinity. The rate of convergence has been estimated using Fourier analysis, but we present an elementary method, which is easier to apply and provides a better estimation in the widely studied case of a uniformly distributed random variable.
Directory of Open Access Journals (Sweden)
Bogdan Gheorghe Munteanu
2013-01-01
Full Text Available Using the stochastic approximations, in this paper it was studiedthe convergence in distribution of the fractional parts of the sum of random variables to the truncated exponential distribution with parameter lambda. This fact is feasible by means of the Fourier-Stieltjes sequence (FSS of the random variable.
An almost Sure Central Limit Theorem for the Weight Function Sequences of NA Random Variables
Indian Academy of Sciences (India)
Qunying Wu
2011-08-01
Consider the weight function sequences of NA random variables. This paper proves that the almost sure central limit theorem holds for the weight function sequences of NA random variables. Our results generalize and improve those on the almost sure central limit theorem previously obtained from the i.i.d. case to NA sequences.
Strong Approximation Theorems for Sums of Random Variables When Extreme Terms are Excluded
Institute of Scientific and Technical Information of China (English)
ZHANG Li Xin
2002-01-01
Let {Xn; n ≥1} be a sequence of i.i.d. random variables and let Xn(r) = Xj if |Xj| is the and necessary conditions for (r)Sn approximating to sums of independent normal random variables are obtained. Via approximation results, the convergence rates of the strong law of large numbers for (r)Sn are studied.
LARGE DEVIATION FOR THE EMPIRICAL CORRELATION COEFFICIENT OF TWO GAUSSIAN RANDOM VARIABLES
Institute of Scientific and Technical Information of China (English)
Shen Si
2007-01-01
In this article, the author obtains the large deviation principles for the empirical correlation coefficient of two Gaussian random variables X and Y. Especially, when considering two independent Gaussian random variables X, Y with the means EX, EY(both known), wherein the author gives two kinds of different proofs and gets the same results.
Institute of Scientific and Technical Information of China (English)
Ji-hua Xu; Jing-hui Zhao
2000-01-01
After giving the representation of moment gqnerating function for the S-λ type random variable by solving a differential equation, we prove that this type random variable is of regular n-r order moment. Furthermore we establish the higher order asymptotic formula for generalized Feller operators by making use of the generalized Taylor formula.
Institute of Scientific and Technical Information of China (English)
Guo Ming-le; Xu Chun-yu; Zhu Dong-jin
2014-01-01
In this paper, we discuss the complete convergence of weighted sums for arrays of rowwise m-negatively associated random variables. By applying moment inequality and truncation methods, the sufficient conditions of complete convergence of weighted sums for arrays of rowwise m-negatively associated random variables are established. These results generalize and complement some known conclusions.
Complete Convergence for Arrays of Rowwise ϕ-mixing Random Variables
Institute of Scientific and Technical Information of China (English)
LI Jing
2013-01-01
In the paper, the complete convergence for arrays of rowwise ϕ-mixing random variables is studied. Some sufficient conditions for complete convergence for an array of row-wiseϕ-mixing random variables without assumptions of identical distribution and stochastic domination are presented.
Fuzzy random variables — II. Algorithms and examples for the discrete case
Kwakernaak, Huibert
1979-01-01
The results obtained in part I of the paper are specialized to the case of discrete fuzzy random variables. A more intuitive interpretation is given of the notion of fuzzy random variables. Algorithms are derived for determining expectations, fuzzy probabilities, fuzzy conditional expectations and f
Stochastic Optimal Estimation with Fuzzy Random Variables and Fuzzy Kalman Filtering
Institute of Scientific and Technical Information of China (English)
FENG Yu-hu
2005-01-01
By constructing a mean-square performance index in the case of fuzzy random variable, the optimal estimation theorem for unknown fuzzy state using the fuzzy observation data are given. The state and output of linear discrete-time dynamic fuzzy system with Gaussian noise are Gaussian fuzzy random variable sequences. An approach to fuzzy Kalman filtering is discussed. Fuzzy Kalman filtering contains two parts: a real-valued non-random recurrence equation and the standard Kalman filtering.
Bias in random forest variable importance measures: Illustrations, sources and a solution
Directory of Open Access Journals (Sweden)
Hothorn Torsten
2007-01-01
Full Text Available Abstract Background Variable importance measures for random forests have been receiving increased attention as a means of variable selection in many classification tasks in bioinformatics and related scientific fields, for instance to select a subset of genetic markers relevant for the prediction of a certain disease. We show that random forest variable importance measures are a sensible means for variable selection in many applications, but are not reliable in situations where potential predictor variables vary in their scale of measurement or their number of categories. This is particularly important in genomics and computational biology, where predictors often include variables of different types, for example when predictors include both sequence data and continuous variables such as folding energy, or when amino acid sequence data show different numbers of categories. Results Simulation studies are presented illustrating that, when random forest variable importance measures are used with data of varying types, the results are misleading because suboptimal predictor variables may be artificially preferred in variable selection. The two mechanisms underlying this deficiency are biased variable selection in the individual classification trees used to build the random forest on one hand, and effects induced by bootstrap sampling with replacement on the other hand. Conclusion We propose to employ an alternative implementation of random forests, that provides unbiased variable selection in the individual classification trees. When this method is applied using subsampling without replacement, the resulting variable importance measures can be used reliably for variable selection even in situations where the potential predictor variables vary in their scale of measurement or their number of categories. The usage of both random forest algorithms and their variable importance measures in the R system for statistical computing is illustrated and
'Sequence' dependent elasticity and local stiffness of a random heteropolymer
International Nuclear Information System (INIS)
We study the 'sequence' distribution of thermally averaged global and local elastic properties of a random heteropolymer of fixed length N, within the framework of a disordered Kratky–Porod (KP) model. We arrive at a number of qualitative results on the form of the distribution function of the thermally averaged end-to-end distance (R2), and its moments. For long N→∞ chains, this distribution is a Gaussian; for shorter chains, there is a crossover to an exponential distribution, with the most probable end-to-end distance deviating significantly from the mean. Further, the distributions of local quantities related to the thermally averaged tangent–tangent correlator are typically broad, even in the thermodynamic limit, i.e., they do not self-average. This is consistent with the general consensus that DNA–protein binding/unbinding strengths and rates are sensitive to local elastic distortion which is 'sequence' dependent
Generating Variable and Random Schedules of Reinforcement Using Microsoft Excel Macros
Bancroft, Stacie L; Bourret, Jason C
2008-01-01
Variable reinforcement schedules are used to arrange the availability of reinforcement following varying response ratios or intervals of time. Random reinforcement schedules are subtypes of variable reinforcement schedules that can be used to arrange the availability of reinforcement at a constant probability across number of responses or time. Generating schedule values for variable and random reinforcement schedules can be difficult. The present article describes the steps necessary to writ...
Concentrated Hitting Times of Randomized Search Heuristics with Variable Drift
DEFF Research Database (Denmark)
Lehre, Per Kristian; Witt, Carsten
2014-01-01
Drift analysis is one of the state-of-the-art techniques for the runtime analysis of randomized search heuristics (RSHs) such as evolutionary algorithms (EAs), simulated annealing etc. The vast majority of existing drift theorems yield bounds on the expected value of the hitting time for a target...... precise sharp-concentration results on the running time of a simple EA on standard benchmark problems, including the class of general linear functions. The usefulness of the theorem outside the theory of RSHs is demonstrated by deriving tail bounds on the number of cycles in random permutations. All...
Local search methods based on variable focusing for random K-satisfiability.
Lemoy, Rémi; Alava, Mikko; Aurell, Erik
2015-01-01
We introduce variable focused local search algorithms for satisfiabiliity problems. Usual approaches focus uniformly on unsatisfied clauses. The methods described here work by focusing on random variables in unsatisfied clauses. Variants are considered where variables are selected uniformly and randomly or by introducing a bias towards picking variables participating in several unsatistified clauses. These are studied in the case of the random 3-SAT problem, together with an alternative energy definition, the number of variables in unsatisfied constraints. The variable-based focused Metropolis search (V-FMS) is found to be quite close in performance to the standard clause-based FMS at optimal noise. At infinite noise, instead, the threshold for the linearity of solution times with instance size is improved by picking preferably variables in several UNSAT clauses. Consequences for algorithmic design are discussed. PMID:25679737
THE STRUCTURE AND PRECISE MODERATE DEVIATIONS OF RANDOM VARIABLES WITH DOMINATEDLY VARYING TAILS
Institute of Scientific and Technical Information of China (English)
WANG Yuebao; YANG Yang
2005-01-01
This paper shows the structure of the random variables with dominatedly varying tails and that of the associated random variables,and obtains some results on these r.v.s' precise moderate deviations with random centralizing constants,which extend the boundary γλ(t) of large deviations to γ(λ(t))1/s,where γ＞0,1＜s＜2,λ(t) is the expectation of the random index N(t),t＞O.
Institute of Scientific and Technical Information of China (English)
2009-01-01
In this paper, we establish some Rosenthal type inequalities for maximum partial sums of asymptotically almost negatively associated random variables, which extend the corresponding results for negatively associated random variables. As applications of these inequalities, by employing the notions of residual Cesàro α-integrability and strong residual Cesàro α-integrability, we derive some results on Lp convergence where 1 < p < 2 and complete convergence. In addition, we estimate the rate of convergence in Marcinkiewicz-Zygmund strong law for partial sums of identically distributed random variables.
Institute of Scientific and Technical Information of China (English)
YUAN DeMei; AN Jun
2009-01-01
In this paper, we establish some Rosenthal type inequalities for maximum partial sums of asymptotically almost negatively associated random variables, which extend the corresponding results for negatively associated random variables. As applications of these inequalities, by employing the notions of residual Cesaro α-integrability and strong residual Cesaro α-integrability, we derive some results on Lp convergence where 1
random variables.
On the Strong Law of Large Numbers for Non-Independent B-Valued Random Variables
Institute of Scientific and Technical Information of China (English)
Gan Shi-xin
2004-01-01
This paper investigates some conditions which imply the strong laws of large numbers for Banach space valued random variable sequences. Some generalizations of the Marcinkiewicz-Zygmund theorem and the Hoffmann-Jφrgensen and Pisier theorem are obtained.
Zero Distribution of System with Unknown Random Variables Case Study: Avoiding Collision Path
Directory of Open Access Journals (Sweden)
Parman Setyamartana
2014-07-01
Full Text Available This paper presents the stochastic analysis of finding the feasible trajectories of robotics arm motion at obstacle surrounding. Unknown variables are coefficients of polynomials joint angle so that the collision-free motion is achieved. ãk is matrix consisting of these unknown feasible polynomial coefficients. The pattern of feasible polynomial in the obstacle environment shows as random. This paper proposes to model the pattern of this randomness values using random polynomial with unknown variables as coefficients. The behavior of the system will be obtained from zero distribution as the characteristic of such random polynomial. Results show that the pattern of random polynomial of avoiding collision can be constructed from zero distribution. Zero distribution is like building block of the system with obstacles as uncertainty factor. By scale factor k, which has range, the random coefficient pattern can be predicted.
Random variables as pathwise integrals with respect to fractional Brownian motion
Mishura, Yuliya; Valkeila, Esko
2011-01-01
We show that a pathwise stochastic integral with respect to fractional Brownian motion with an adapted integrand $g$ can have any prescribed distribution, moreover, we give both necessary and sufficient conditions when random variables can be represented in this form. We also prove that any random variable is a value of such integral in some improper sense. We discuss some applications of these results, in particular, to fractional Black--Scholes model of financial market.
Bujok, K.; Hambly, B. M.; Reisinger, C.
2012-01-01
We consider $N$ Bernoulli random variables, which are independent conditional on a common random factor determining their probability distribution. We show that certain expected functionals of the proportion $L_N$ of variables in a given state converge at rate 1/N as $N\\rightarrow \\infty$. Based on these results, we propose a multi-level simulation algorithm using a family of sequences with increasing length, to obtain estimators for these expected functionals with a mean-square error of $\\ep...
A Robbins-Monro procedure for the estimation of parametric deformations on random variables
Fraysse, Philippe; Lescornel, Hélène; Loubès, Jean-Michel
2013-01-01
The paper is devoted to the study of a parametric deformation model of independent and identically random variables. Firstly, we construct an efficient and very easy to compute recursive estimate of the parameter. Our stochastic estimator is similar to the Robbins-Monro procedure where the contrast function is the Wasserstein distance. Secondly, we propose a recursive estimator similar to that of Parzen-Rosenblatt kernel density estimator in order to estimate the density of the random variabl...
Sample estimation of distribution parameters if upper and lower bounds of random variable are known
International Nuclear Information System (INIS)
The point and interval distribution parameter estimators are obtained by direct numerical approximation of the definition integral with the use of upper and lower bounds of distributed random variable. Like in Bayesian estimation, the distribution parameters are treated as random variables, and their uncertainty is described as a distribution. The Monte Carlo procedure is involved to get the posteriori parameter distributions and the correspondent confidence interval limits.
The discovery of timescale-dependent color variability of quasars
International Nuclear Information System (INIS)
Quasars are variable on timescales from days to years in UV/optical and generally appear bluer while they brighten. The physics behind the variations in fluxes and colors remains unclear. Using Sloan Digital Sky Survey g- and r-band photometric monitoring data for quasars in Stripe 82, we find that although the flux variation amplitude increases with timescale, the color variability exhibits the opposite behavior. The color variability of quasars is prominent at timescales as short as ∼10 days, but gradually reduces toward timescales up to years. In other words, the variable emission at shorter timescales is bluer than that at longer timescales. This timescale dependence is clearly and consistently detected at all redshifts from z = 0 to 3.5; thus, it cannot be due to contamination to broadband photometry from emission lines that do not respond to fast continuum variations. The discovery directly rules out the possibility that simply attributes the color variability to contamination from a non-variable redder component such as the host galaxy. It cannot be interpreted as changes in global accretion rate either. The thermal accretion disk fluctuation model is favored in the sense that fluctuations in the inner, hotter region of the disk are responsible for short-term variations, while longer-term and stronger variations are expected from the larger and cooler disk region. An interesting implication is that one can use quasar variations at different timescales to probe disk emission at different radii.
Small, Dylan S.
2011-01-01
In randomized trials, researchers are often interested in mediation analysis to understand how a treatment works, in particular how much of a treatment's effect is mediated by an intermediated variable and how much the treatment directly affects the outcome not through the mediator. The standard regression approach to mediation analysis assumes sequential ignorability of the mediator, that is that the mediator is effectively randomly assigned given baseline covariates and the randomized treat...
On the Strong Laws for Weighted Sums of m-negatively Asso ciated Random Variables
Institute of Scientific and Technical Information of China (English)
WU Yong-feng
2014-01-01
In this article, the author establishes the strong laws for linear statistics that are weighted sums of a m-negatively associated(m-NA) random sample. The obtained results extend and improve the result of Qiu and Yang in [1] to m-NA random variables.
Stability of Random Variables and Iterated Logarithm Laws for Martingales and Quadratic Forms
Fernholz, Luisa Turrin; Teicher, Henry
1980-01-01
Strong laws of large numbers, obtained for positive, independent random variables, are utilized to prove iterated logarithm laws (with a nonrandom normalizing sequence) for a class of martingales. A law of the iterated logarithm is also established for certain random quadratic forms.
Institute of Scientific and Technical Information of China (English)
高海峰; 白广忱; 高阳; 鲍天未
2015-01-01
The fatigue life of aeroengine turbine disc presents great dispersion due to the randomness of the basic variables, such as applied load, working temperature, geometrical dimensions and material properties. In order to ameliorate reliability analysis efficiency without loss of reliability, the distributed collaborative response surface method (DCRSM) was proposed, and its basic theories were established in this work. Considering the failure dependency among the failure modes, the distributed response surface was constructed to establish the relationship between the failure mode and the relevant random variables. Then, the failure modes were considered as the random variables of system response to obtain the distributed collaborative response surface model based on structure failure criterion. Finally, the given turbine disc structure was employed to illustrate the feasibility and validity of the presented method. Through the comparison of DCRSM, Monte Carlo method (MCM) and the traditional response surface method (RSM), the results show that the computational precision for DCRSM is more consistent with MCM than RSM, while DCRSM needs far less computing time than MCM and RSM under the same simulation conditions. Thus, DCRSM is demonstrated to be a feasible and valid approach for improving the computational efficiency of reliability analysis for aeroengine turbine disc fatigue life with multiple random variables, and has great potential value for the complicated mechanical structure with multi-component and multi-failure mode.
Couso, Inés; Sánchez, Luciano
2014-01-01
This short book provides a unified view of the history and theory of random sets and fuzzy random variables, with special emphasis on its use for representing higher-order non-statistical uncertainty about statistical experiments. The authors lay bare the existence of two streams of works using the same mathematical ground, but differing form their use of sets, according to whether they represent objects of interest naturally taking the form of sets, or imprecise knowledge about such objects. Random (fuzzy) sets can be used in many fields ranging from mathematical morphology, economics, artificial intelligence, information processing and statistics per se, especially in areas where the outcomes of random experiments cannot be observed with full precision. This book also emphasizes the link between random sets and fuzzy sets with some techniques related to the theory of imprecise probabilities. This small book is intended for graduate and doctoral students in mathematics or engineering, but also provides an i...
Shoulder pain and time dependent structure in wheelchair propulsion variability.
Jayaraman, Chandrasekaran; Moon, Yaejin; Sosnoff, Jacob J
2016-07-01
Manual wheelchair propulsion places considerable repetitive mechanical strain on the upper limbs leading to shoulder injury and pain. While recent research indicates that the amount of variability in wheelchair propulsion and shoulder pain may be related. There has been minimal inquiry into the fluctuation over time (i.e. time-dependent structure) in wheelchair propulsion variability. Consequently the purpose of this investigation was to examine if the time-dependent structure in the wheelchair propulsion parameters are related to shoulder pain. 27 experienced wheelchair users manually propelled their own wheelchair fitted with a SMARTWheel on a roller at 1.1m/s for 3min. Time-dependent structure of cycle-to-cycle fluctuations in contact angle and inter push time interval was quantified using sample entropy (SampEn) and compared between the groups with/without shoulder pain using non-parametric statistics. Overall findings were, (1) variability observed in contact angle fluctuations during manual wheelchair propulsion is structured (Z=3.15;pshoulder pain exhibited higher SampEn magnitude for contact angle during wheelchair propulsion than those without pain (χ(2)(1)=6.12;pshoulder pain (rs (WUSPI) =0.41;rs (VAS)=0.56;pshoulder pain. PMID:27134151
LARGE DEVIATIONS FOR SUMS OF INDEPENDENT RANDOM VARIABLES WITH DOMINATEDLY VARYING TAILS
Institute of Scientific and Technical Information of China (English)
Kong Fanchao; Zhang Ying
2007-01-01
In this paper the large deviation results for partial and random sums Sn-ESn=n∑i=1Xi-n∑i=1EXi,n≥1;S(t)-ES(t)=N(t)∑i=1Xi-E(N(t)∑i=1Xi),t≥0are proved, where {N(t); t≥ 0} is a counting process of non-negative integer-valued random variables, and {Xn; n ≥ 1} are a sequence of independent non-negative random variables independent of {N(t); t ≥ 0}. These results extend and improve some known conclusions.
Dasgupta, Sakyasingha; Nishikawa, Isao; Aihara, Kazuyuki; Toyoizumi, Taro
Source of cortical variability and its influence on signal processing remain an open question. We address the latter, by studying two types of balanced randomly connected networks of quadratic I-F neurons, with irregular spontaneous activity: (a) a deterministic network with strong connections generating noise by chaotic dynamics (b) a stochastic network with weak connections receiving noisy input. They are analytically tractable in the limit of large network-size and channel time-constant. Despite different sources of noise, spontaneous activity of these networks are identical unless majority of neurons are simultaneously recorded. However, the two networks show remarkably different sensitivity to external stimuli. In the former, input reverberates internally and can be read out over long time, but in the latter, inputs rapidly decay. This is further enhanced with activity-dependent plasticity at input synapses producing marked difference in decoding inputs from neural activity. We show, this leads to distinct performance of the two networks to integrate temporally separate signals from multiple sources, with the deterministic chaotic network activity serving as reservoir for Monte Carlo sampling to perform near optimal Bayesian integration, unlike its stochastic counterpart.
Generating Variable and Random Schedules of Reinforcement Using Microsoft Excel Macros
Bancroft, Stacie L.; Bourret, Jason C.
2008-01-01
Variable reinforcement schedules are used to arrange the availability of reinforcement following varying response ratios or intervals of time. Random reinforcement schedules are subtypes of variable reinforcement schedules that can be used to arrange the availability of reinforcement at a constant probability across number of responses or time.…
The Central Limit Theorem for Exchangeable Random Variables Without Moments
Klass, Michael; Teicher, Henry
1987-01-01
If $\\{X_n, n \\geq 1\\}$ is an exchangeable sequence with $(1/b_n(\\sum^n_1X_i - a_n)) \\rightarrow N(0, 1)$ for some constants $a_n$ and $0 < b_n \\rightarrow \\infty$ then $b_n/n^\\alpha$ is slowly varying with $\\alpha = 1$ or $\\frac{1}{2}$ and necessary conditions (depending on $\\alpha$) which are also sufficient, are obtained. Three such examples are given, one with infinite mean, one with no positive moments, and the third with almost all conditional distributions belonging to no domain of attr...
DEFF Research Database (Denmark)
Krøigård, Thomas; Gaist, David; Otto, Marit;
2014-01-01
SUMMARY: The reproducibility of variables commonly included in studies of peripheral nerve conduction in healthy individuals has not previously been analyzed using a random effects regression model. We examined the temporal changes and variability of standard nerve conduction measures in the leg...... conduction studies have a high reproducibility, and variables are mainly unaltered during 6 months. This study provides a solid basis for the planning of future clinical trials assessing changes in nerve conduction....
Correction to: "On the Chambers-Mallows-Stuck Method for Simulating Skewed Stable Random Variables"
Weron, Rafal
1996-01-01
In the paper Weron (1996, Statist. Probab. Lett. 28, 165-171), I gave a proof to the equality in law of a skewed stable variable and a nonlinear transformation of two independent uniform and exponential variables. The Chambers et al. (1976, J. Amer. Statist. Assoc. 71, 340–344) method of computer generation of a skewed stable random variable is based on this equality. Unfortunately an error crept into my calculations for alpha=1. This note corrects the error.
Variable Selection for Varying-Coefficient Models with Missing Response at Random
Institute of Scientific and Technical Information of China (English)
Pei Xin ZHAO; Liu Gen XUE
2011-01-01
In this paper, we present a variable selection procedure by combining basis function approximations with penalized estimating equations for varying-coefficient models with missing response at random. With appropriate selection of the tuning parameters, we establish the consistency of the variable selection procedure and the optimal convergence rate of the regularized estimators. A simulation study is undertaken to assess the finite sample performance of the proposed variable selection procedure.
Vardeman, Stephen B.; Wendelberger, Joanne R.
2004-01-01
There is a little-known but very simple generalization of the standard result that for uncorrelated variables with a common mean and variance, the expected sample variance is the marginal variance. The generalization justifies the use of the usual standard error of the sample mean in possibly heteroscedastic situations and motivates some simple estimators for unbalanced linear random effects models. The latter is illustrated for the simple one-way context.
Scalable statistics of correlated random variables and extremes applied to deep borehole porosities
Guadagnini, A.; Neuman, S. P.; Nan, T.; Riva, M.; Winter, C. L.
2015-02-01
We analyze scale-dependent statistics of correlated random hydrogeological variables and their extremes using neutron porosity data from six deep boreholes, in three diverse depositional environments, as example. We show that key statistics of porosity increments behave and scale in manners typical of many earth and environmental (as well as other) variables. These scaling behaviors include a tendency of increments to have symmetric, non-Gaussian frequency distributions characterized by heavy tails that decay with separation distance or lag; power-law scaling of sample structure functions (statistical moments of absolute increments) in midranges of lags; linear relationships between log structure functions of successive orders at all lags, known as extended self-similarity or ESS; and nonlinear scaling of structure function power-law exponents with function order, a phenomenon commonly attributed in the literature to multifractals. Elsewhere we proposed, explored and demonstrated a new method of geostatistical inference that captures all of these phenomena within a unified theoretical framework. The framework views data as samples from random fields constituting scale mixtures of truncated (monofractal) fractional Brownian motion (tfBm) or fractional Gaussian noise (tfGn). Important questions not addressed in previous studies concern the distribution and statistical scaling of extreme incremental values. Of special interest in hydrology (and many other areas) are statistics of absolute increments exceeding given thresholds, known as peaks over threshold or POTs. In this paper we explore the statistical scaling of data and, for the first time, corresponding POTs associated with samples from scale mixtures of tfBm or tfGn. We demonstrate that porosity data we analyze possess properties of such samples and thus follow the theory we proposed. The porosity data are of additional value in revealing a remarkable cross-over from one scaling regime to another at certain
Modelling the statistical dependence of rainfall event variables by a trivariate copula function
Directory of Open Access Journals (Sweden)
M. Balistrocchi
2011-01-01
Full Text Available In many hydrological models, such as those derived by analytical probabilistic methods, the precipitation stochastic process is represented by means of individual storm random variables which are supposed to be independent of each other. However, several proposals were advanced to develop joint probability distributions able to account for the observed statistical dependence. The traditional technique of the multivariate statistics is nevertheless affected by several drawbacks, whose most evident issue is the unavoidable subordination of the dependence structure assessment to the marginal distribution fitting. Conversely, the copula approach can overcome this limitation, by splitting the problem in two distinct items. Furthermore, goodness-of-fit tests were recently made available and a significant improvement in the function selection reliability has been achieved. Herein a trivariate probability distribution of the rainfall event volume, the wet weather duration and the interevent time is proposed and verified by test statistics with regard to three long time series recorded in different Italian climates. The function was developed by applying a mixing technique to bivariate copulas, which were formerly obtained by analyzing the random variables in pairs. A unique probabilistic model seems to be suitable for representing the dependence structure, despite the sensitivity shown by the dependence parameters towards the threshold utilized in the procedure for extracting the independent events. The joint probability function was finally developed by adopting a Weibull model for the marginal distributions.
On the use of fractional calculus for the probabilistic characterization of random variables
Cottone, Giulio; 10.1016/j.probengmech.2008.08.002
2013-01-01
In this paper, the classical problem of the probabilistic characterization of a random variable is re-examined. A random variable is usually described by the probability density function (PDF) or by its Fourier transform, namely the characteristic function (CF). The CF can be further expressed by a Taylor series involving the moments of the random variable. However, in some circumstances, the moments do not exist and the Taylor expansion of the CF is useless. This happens for example in the case of $\\alpha$--stable random variables. Here, the problem of representing the CF or the PDF of random variables (r.vs) is examined by introducing fractional calculus. Two very remarkable results are obtained. Firstly, it is shown that the fractional derivatives of the CF in zero coincide with fractional moments. This is true also in case of CF not derivable in zero (like the CF of $\\alpha$--stable r.vs). Moreover, it is shown that the CF may be represented by a generalized Taylor expansion involving fractional moments. ...
CONVERGENCE RATES IN THE STRONG LAWS FOR A CLASS OF DEPENDENT RANDOM FIFLDS
Institute of Scientific and Technical Information of China (English)
CaiGuanghui
2003-01-01
By using a Rosenthal type inequality established in this paper,the complete convergence rates in the strong laws for a class of dependent random fields are discussed.And the result obtained extends those for ρ--mixing random fields,ρ*-mixing random fields and negatively associated fields.
Epoch-dependent absorption line profile variability in lambda Cep
Uuh-Sonda, J M; Eenens, P; Mahy, L; Palate, M; Gosset, E; Flores, C A
2014-01-01
We present the analysis of a multi-epoch spectroscopic monitoring campaign of the O6Ief star lambda Cep. Previous observations reported the existence of two modes of non-radial pulsations in this star. Our data reveal a much more complex situation. The frequency content of the power spectrum considerably changes from one epoch to the other. We find no stable frequency that can unambiguously be attributed to pulsations. The epoch-dependence of the frequencies and variability patterns are similar to what is seen in the wind emission lines of this and other Oef stars, suggesting that both phenomena likely have the same, currently still unknown, origin.
A Particle Swarm Optimization Algorithm with Variable Random Functions and Mutation
Institute of Scientific and Technical Information of China (English)
ZHOU Xiao-Jun; YANG Chun-Hua; GUI Wei-Hua; DONG Tian-Xue
2014-01-01
The convergence analysis of the standard particle swarm optimization (PSO) has shown that the changing of random functions, personal best and group best has the potential to improve the performance of the PSO. In this paper, a novel strategy with variable random functions and polynomial mutation is introduced into the PSO, which is called particle swarm optimization algorithm with variable random functions and mutation (PSO-RM). Random functions are adjusted with the density of the population so as to manipulate the weight of cognition part and social part. Mutation is executed on both personal best particle and group best particle to explore new areas. Experiment results have demonstrated the effectiveness of the strategy.
Autoclassification of the Variable 3XMM Sources Using the Random Forest Machine Learning Algorithm
Farrell, Sean A; Lo, Kitty K
2015-01-01
In the current era of large surveys and massive data sets, autoclassification of astrophysical sources using intelligent algorithms is becoming increasingly important. In this paper we present the catalog of variable sources in the Third XMM-Newton Serendipitous Source catalog (3XMM) autoclassified using the Random Forest machine learning algorithm. We used a sample of manually classified variable sources from the second data release of the XMM-Newton catalogs (2XMMi-DR2) to train the classifier, obtaining an accuracy of ~92%. We also evaluated the effectiveness of identifying spurious detections using a sample of spurious sources, achieving an accuracy of ~95%. Manual investigation of a random sample of classified sources confirmed these accuracy levels and showed that the Random Forest machine learning algorithm is highly effective at automatically classifying 3XMM sources. Here we present the catalog of classified 3XMM variable sources. We also present three previously unidentified unusual sources that wer...
Institute of Scientific and Technical Information of China (English)
Pei Xin ZHAO; Liu Gen XUE
2011-01-01
In this paper,we present a variable selection procedure by combining basis function approximations with penalized estimating equations for semiparametric varying-coefficient partially linear models with missing response at random.The proposed procedure simultaneously selects significant variables in parametric components and nonparametric components.With appropriate selection of the tuning parameters,we establish the consistency of the variable selection procedure and the convergence rate of the regularized estimators.A simulation study is undertaken to assess the finite sample performance of the proposed variable selection procedure.
Effect of spatial variability on the slope stability using Random Field Numerical Limit Analyses
Kasama, Kiyonobu; Whittle, Andrew
2015-01-01
This paper presents a probabilistic approach to evaluating the geotechnical stability problem by incorporating the stochastic spatial variability of soil property within the numerical limit analyses (NLAs). The undrained shear strength and unit weight of soil are treated as a random field which is characterized by a log-normal distribution and a spatial correlation length. The current calculations use a Cholesky Decomposition technique to incorporate these random properties in NLAs. The Rando...
Zwan, van der, G.; Vente, de, W.; Huizink, A.C.; Bögels, S.M.; Bruin, de, B.
2015-01-01
In contemporary western societies stress is highly prevalent, therefore the need for stress-reducing methods is great. This randomized controlled trial compared the efficacy of self-help physical activity (PA), mindfulness meditation (MM), and heart rate variability biofeedback (HRV-BF) in reducing stress and its related symptoms. We randomly allocated 126 participants to PA, MM, or HRV-BF upon enrollment, of whom 76 agreed to participate. The interventions consisted of psycho-education and a...
The generation of dependent input variables to a performance assessment simulation code
International Nuclear Information System (INIS)
Mathematical models are being developed in many countries to aid in the assessment of risks associated with the deep geologic disposal of high-level nuclear wastes. The models are designed to simulate one or more steps in the following scenario: waste containment is lost, and the radionuclides are released from the repository, are transported to the biosphere, and become accessible to man. The models typically involve a large number of variables that may be highly dependent. When the models are implemented in computer simulation codes, it becomes necessary to generate input values for these variables. Widely used methods for generating input values, such as simple random sampling (SRS) and Latin hypercube sampling (LHS), do not necessarily produce samples that are consistent with the known dependence structure of the input variables. Moreover, it is procedurally impracticable to generate realizations of correlated input variables from many multivariate probability distributions of interest. Two important cases in which it is feasible to generate multivariate realizations are those in which all input variables are either normally distributed or mutually independent. Neither case is adequate for large-scale performance assessment codes with many input variables. Iman and Conover (1982) have developed a practical method for generating nonzero pairwise rank correlations among the components of an input vector that overcomes some of these difficulties. The method requires samples of specified size from the marginal (univariate) distributions of the input variables. The method further requires a target matrix of desired pairwise correlations among the input variables. The Cholesky decomposition of the target matrix is used to transform the rank matrix of the input sample
Scheduling of Dependent Tasks Application using Random Search Technique
vegda, Deepak. c.; Prajapati, Harshad B.
2013-01-01
Since beginning of Grid computing, scheduling of dependent tasks application has attracted attention of researchers due to NP-Complete nature of the problem. In Grid environment, scheduling is deciding about assignment of tasks to available resources. Scheduling in Grid is challenging when the tasks have dependencies and resources are heterogeneous. The main objective in scheduling of dependent tasks is minimizing make-span. Due to NP-complete nature of scheduling problem, exact solutions can...
Convergence in distribution norms in the CLT for non identical distributed random variables
Bally, Vlad; Caramellino, Lucia; Poly, Guillaume
2016-01-01
We study the convergence in distribution norms in the Central Limit Theorem for non identical distributed random variables that is $$ \\varepsilon _{n}(f):=\\mathbb{E}\\Big(f\\Big(\\sum_{i=1}^{n}Z_{i}\\Big)\\Big)-\\mathbb{E}\\big(f(G)\\big)\\rightarrow 0 $$ where $S_{n}=\\sum_{i=1}^{n}Z_{i}$ with $Z_{i}$ centred independent random variables (with a suitable re-normalization for $S_{n}$) and $G$ is standard normal. We also consider local developments (Edgeworth expansion). This kind of results is well und...
Exponential inequalities for associated random variables and strong laws of large numbers
Institute of Scientific and Technical Information of China (English)
Shan-chao YANG; Min CHEN
2007-01-01
Some exponential inequalities for partial sums of associated random variables are established. These inequalities improve the corresponding results obtained by Ioannides and Roussas (1999), and Oliveira (2005). As application, some strong laws of large numbers are given. For the case of geometrically decreasing covariances, we obtain the rate of convergence n-1/2(log log n)1/2(log n) which is close to the optimal achievable convergence rate for independent random variables under an iterated logarithm, while Ioannides and Roussas (1999), and Oliveira (2005) only got n-1/3 (log n)2/3 and n-1/3 (log n)5/3, separately.
Exponential inequalities for associated random variables and strong laws of large numbers
Institute of Scientific and Technical Information of China (English)
2007-01-01
Some exponential inequalities for partial sums of associated random variables are established. These inequalities improve the corresponding results obtained by Ioannides and Roussas (1999), and Oliveira (2005). As application, some strong laws of large numbers are given. For the case of geometrically decreasing covariances, we obtain the rate of convergence n-1/2(log log n)1/2(logn) which is close to the optimal achievable convergence rate for independent random variables under an iterated logarithm, while Ioannides and Roussas (1999), and Oliveira (2005) only got n-1/3(logn)2/3 and n-1/3(logn)5/3, separately.
A note on strong law of large numbers of random variables
Institute of Scientific and Technical Information of China (English)
LIN Zheng-yan; SHEN Xin-mei
2006-01-01
In this paper, the Chung's strong law of large numbers is generalized to the random variables which do not need the condition of independence, while the sequence of Borel functions verifies some conditions weaker than that in Chung's theorem.Some convergence theorems for martingale difference sequence such as Lp martingale difference sequence are the particular cases of results achieved in this paper. Finally, the convergence theorem for A-summability of sequence of random variables is proved,where A is a suitable real infinite matrix.
ON THE LIMITING BEHAVIOR OF THE MAXIMUM PARTIAL SUMS FOR ARRAYS OF ROWWISE NA RANDOM VARIABLES
Institute of Scientific and Technical Information of China (English)
无
2007-01-01
Let {Xni, 1 ≤ n,i ＜∞} be an array of rowwise NA random variables and {an, n ≥ 1} a sequence of constants with 0 ＜ an ↑∞. The limiting behavior of maximum partial sums 1/an max 1≤k≤n| kΣi=1 Xni| is investigated and some new results are obtained. The results extend and improve the corresponding theorems of rowwise independent random variable arrays by Hu and Taylor [1] and Hu and Chang [2].
The Law of the Iterated Logarithm for Independent Random Variables with Multidimensional Indices
Li, Deli; Rao, M. Bhaskara; Wang, Xiangchen
1992-01-01
Let $X_{\\bar n}, \\bar{n} \\in \\mathbb{N}^d$, be a field of independent real random variables, where $\\mathbb{N}^d$ is the $d$-dimensional lattice. In this paper, the law of the iterated logarithm is established for such a field of random variables. Theorem 1 brings into focus a connection between a certain strong law of large numbers and the law of the iterated logarithm. A general technique is developed by which one can derive the strong law of large numbers and the law of the iterated logari...
Randomly Weighted Sums for Negatively Associated Random Variables with Heavy Tails%重尾情形下NA随机变量的随机加权和
Institute of Scientific and Technical Information of China (English)
宗高峰; 孔繁超
2009-01-01
In 2003, Tang Qihe et al. obtained a simple asymptotic formula for independent identically distributed (i.i.d.) random variables with heavy tails. In this paper, under certain moment conditions, we establish a formula as the same as Tang's, when random variables are negatively associated (NA).
A Simple Linear Ranking Algorithm Using Query Dependent Intercept Variables
Ailon, Nir
2008-01-01
The LETOR website contains three information retrieval datasets used as a benchmark for testing machine learning ideas for ranking. Algorithms participating in the challenge are required to assign score values to search results for a collection of queries, and are measured using standard IR ranking measures (NDCG, precision, MAP) that depend only the relative score-induced order of the results. Similarly to many of the ideas proposed in the participating algorithms, we train a linear classifier. In contrast with other participating algorithms, we define an additional free variable (intercept, or benchmark) for each query. This allows expressing the fact that results for different queries are incomparable for the purpose of determining relevance. The cost of this idea is the addition of relatively few nuisance parameters. Our approach is simple, and we used a standard logistic regression library to test it. The results beat the reported participating algorithms. Hence, it seems promising to combine our approac...
Discovery of Fourier-dependent time lags in cataclysmic variables
Scaringi, S; Groot, P J; Uttley, P; Marsh, T; Knigge, C; Maccarone, T; Dhillon, V S
2013-01-01
We report the first study of Fourier-frequency-dependent coherence and phase/time lags at optical wavelengths of cataclysmic variables (MV Lyr and LU Cam) displaying typical flickering variability in white light. Observations were performed on the William Herschel Telescope using ULTRACAM. Lightcurves for both systems have been obtained with the SDSS filters $u'$, $g'$ and $r'$ simultaneously with cadences between $\\approx0.5-2$ seconds, and allow us to probe temporal frequencies between ~10^{-3} Hz and ~1 Hz. We find high levels of coherence between the u', g' and r' lightcurves up to at least ~10^{-2} Hz. Furthermore we detect red/negative lags where the redder bands lag the bluer ones at the lowest observed frequencies. For MV Lyr time lags up to ~3 seconds are observed, whilst LU Cam displays larger time lags of ~10 seconds. Mechanisms which seek to explain red/negative lags observed in X-ray binaries and Active Galactic Nuclei involve reflection of photons generated close to the compact object onto the s...
On Complete Convergence for Arrays of Rowwise Strong Mixing Random Variables
Institute of Scientific and Technical Information of China (English)
ZHOU XING-CAI; LIN JIN-GUAN; WANG XUE-JUN; HU SHU-HE
2011-01-01
In this paper,we present a general method to prove the complete convergence for arrays of rowwise strong mixing random variables,and give some results on complete convergence under some suitable conditions.Some Marcinkiewicz-Zygmund type strong laws of large numbers are also obtained.
Laws of Large Numbers of Negatively Correlated Random Variables for Capacities
Institute of Scientific and Technical Information of China (English)
Wen-juan LI; Zeng-jing CHEN
2011-01-01
Our aim is to present some limit theorems for capacities.We consider a sequence of pairwise negatively correlated random variables.We obtain laws of large numbers for upper probabilities and 2-aiternating capacities,using some results in the classical probability theory and a non-additive version of Chebyshev's inequality and Borai-Contelli lemma for capacities.
Institute of Scientific and Technical Information of China (English)
2008-01-01
In this paper,we prove a general law of the iterated logarithm (LIL) for independent non-identically distributed B-valued random variables.As an interesting application,we obtain the law of the iterated logarithm for the empirical covariance of Hilbertian autoregressive processes.
Institute of Scientific and Technical Information of China (English)
LIU WeiDong; FU KeAng; ZHANG LiXin
2008-01-01
In this paper, we prove a general law of the iterated logarithm (LIL) for independent non-identically distributed B-valued random variables. As an interesting application, we obtain the law of the iterated logarithm for the empirical covariance of Hilbertian autoregressive processes.
Moments of the maximum of normed partial sums of ρ--mixing random variables
Institute of Scientific and Technical Information of China (English)
LIU Xiang-dong; LIU Jin-xia
2009-01-01
Let {Xn, n ≥ 1} be a sequence of identically distributed ρ--mixing random variables and set Sn= ∑ni=1>Xi,n ≥ 1, the sufficient and necessary conditions for the existence of moments of sup n≥1> |Sn/n1/r|p(00) are given, which are the same as that in the independent case.
Random forest (RF) is popular in ecological and environmental modeling, in part, because of its insensitivity to correlated predictors and resistance to overfitting. Although variable selection has been proposed to improve both performance and interpretation of RF models, it is u...
Zwan, van der J.E.; Vente, de W.; Huizink, A.C.; Bögels, S.M.; Bruin, de E.I.
2015-01-01
In contemporary western societies stress is highly prevalent, therefore the need for stress-reducing methods is great. This randomized controlled trial compared the efficacy of self-help physical activity (PA), mindfulness meditation (MM), and heart rate variability biofeedback (HRV-BF) in reducing
A NONCLASSICAL LAW OF ITERATED LOGARITHM FOR NEGATIVELY ASSOCIATED RANDOM VARIABLES
Institute of Scientific and Technical Information of China (English)
JiangYe
2003-01-01
A nonclassical law of iterated logarithm that holds for a stationary negatively associated sequence of random variables with finite variance is proved in this paper.The proof is based on a Rosenthal type maximal inequality and the subsequence method.This result extends the work of Klesov,Rosalsky(2001)and Shao.Su(1999).
Multilevel Cell Storage and Resistance Variability in Resistive Random Access Memory
Pantelis, D. I.; Karakizis, P. N.; Dragatogiannis, D. A.; Charitidis, C. A.
2016-06-01
Multilevel per cell (MLC) storage in resistive random access memory (ReRAM) is attractive in achieving high-density and low-cost memory and will be required in future. In this chapter, MLC storage and resistance variability and reliability of multilevel in ReRAM are discussed. Different MLC operation schemes with their physical mechanisms and a comprehensive analysis of resistance variability have been provided. Various factors that can induce variability and their effect on the resistance margin between the multiple resistance levels are assessed. The reliability characteristics and the impact on MLC storage have also been assessed.
Oracle Efficient Variable Selection in Random and Fixed Effects Panel Data Models
DEFF Research Database (Denmark)
Kock, Anders Bredahl
This paper generalizes the results for the Bridge estimator of Huang et al. (2008) to linear random and fixed effects panel data models which are allowed to grow in both dimensions. In particular we show that the Bridge estimator is oracle efficient. It can correctly distinguish between relevant...... and irrelevant variables and the asymptotic distribution of the estimators of the coefficients of the relevant variables is the same as if only these had been included in the model, i.e. as if an oracle had revealed the true model prior to estimation. In the case of more explanatory variables than...
Cluster-size dependent randomization traffic flow model
Gao, Kun; Wang, Bing-Hong; Fu, Chuan-Ji; Lu, Yu-Feng
2007-11-01
In order to exhibit the meta-stable states, several slow-to-start rules have been investigated as modification to Nagel-Schreckenberg (NS) model. These models can reproduce some realistic phenomena which are absent in the original NS model. But in these models, the size of cluster is still not considered as a useful parameter. In real traffic, the slow-to-start motion of a standing vehicle often depends on the degree of congestion which can be measured by the clusters' size. According to this idea, we propose a cluster-size dependent slow-to-start model based on the speed-dependent slow-to-start rule (VDR) model. It gives expected results through simulations. Comparing with the VDR model, our new model has a better traffic efficiency and shows richer complex characters.
Random Forests for Metric Learning with Implicit Pairwise Position Dependence
Xiong, Caiming; Xu, Ran; Corso, Jason J
2012-01-01
Metric learning makes it plausible to learn distances for complex distributions of data from labeled data. However, to date, most metric learning methods are based on a single Mahalanobis metric, which cannot handle heterogeneous data well. Those that learn multiple metrics throughout the space have demonstrated superior accuracy, but at the cost of computational efficiency. Here, we take a new angle to the metric learning problem and learn a single metric that is able to implicitly adapt its distance function throughout the feature space. This metric adaptation is accomplished by using a random forest-based classifier to underpin the distance function and incorporate both absolute pairwise position and standard relative position into the representation. We have implemented and tested our method against state of the art global and multi-metric methods on a variety of data sets. Overall, the proposed method outperforms both types of methods in terms of accuracy (consistently ranked first) and is an order of ma...
Structural Fatigue Reliability Based on Extension of Random Loads into Interval Variables
Directory of Open Access Journals (Sweden)
Qiangfeng Wang
2013-01-01
Full Text Available According to the problem that for a structure under random loads, the structural fatigue life cant be directly calculated out by S-N curves and linear Miner cumulative damage rule. Owing to the uncertainty of loads, and the problem of the inaccuracy of calculated structural reliability index for the existence of deviation between measured data in projects and real data, the research method for structural fatigue reliability based on extension of random loads into interval variables is proposed. The innovation is that we can accurately calculate out the interval of the structural fatigue life and reliability index of a structure according to the probability density function of stress level of random loads and the coefficient of variation of measured loads. By practical calculation example, it is proved that this method is more suitable to practical engineering comparing to traditional methods. It will provide a perfect research approach for reliability analysis of the structure under random loads.
Cluster-size dependent randomization traffic flow model
Institute of Scientific and Technical Information of China (English)
Gao Kun; Wang Bing-Hong; Fu Chuan-Ji; Lu Yu-Feng
2007-01-01
In order to exhibit the meta-stable states, several slow-to-start rules have been investigated as modification to Nagel-Schreckenberg (NS) model. These models can reproduce some realistic phenomena which are absent in the original NS model. But in these models, the size of cluster is still not considered as a useful parameter. In real traffic,the slow-to-start motion of a standing vehicle often depends on the degree of congestion which can be measured by the clusters'size. According to this idea, we propose a cluster-size dependent slow-to-start model based on the speeddependent slow-to-start rule (VDR) model. It gives expected results through simulations. Comparing with the VDR model, our new model has a better traffic efficiency and shows richer complex characters.
El-Wakil, S. A.; Sallah, M.; El-Hanbaly, A. M.
2015-10-01
The stochastic radiative transfer problem is studied in a participating planar finite continuously fluctuating medium. The problem is considered for specular- and diffusly-reflecting boundaries with linear anisotropic scattering. Random variable transformation (RVT) technique is used to get the complete average for the solution functions, that are represented by the probability-density function (PDF) of the solution process. In the RVT algorithm, a simple integral transformation to the input stochastic process (the extinction function of the medium) is applied. This linear transformation enables us to rewrite the stochastic transport equations in terms of the optical random variable (x) and the optical random thickness (L). Then the transport equation is solved deterministically to get a closed form for the solution as a function of x and L. So, the solution is used to obtain the PDF of the solution functions applying the RVT technique among the input random variable (L) and the output process (the solution functions). The obtained averages of the solution functions are used to get the complete analytical averages for some interesting physical quantities, namely, reflectivity and transmissivity at the medium boundaries. In terms of the average reflectivity and transmissivity, the average of the partial heat fluxes for the generalized problem with internal source of radiation are obtained and represented graphically.
Hashimoto, H.; Nemani, R. R.
2015-12-01
Regional scale ecosystem modeling requires high-resolution data of surface climate variables. Spatial variability in temperature and precipitation has been well studied over the past two decades resulting in several sophisticated algorithms. However, compared to temperature and precipitation, other surface climate variables, such as humidity, solar radiation and wind speed, are not available to use, even though those data are equally important for ecosystem modeling. The main reason for this is the lack of governing physical equations for interpolating observations and the lack of comparable satellite observations. Therefore, scientists have been using reanalysis data or simply interpolated data for ecosystem modeling, though they are too coarse for regional scale ecosystem analysis. In this study, we developed a method to spatially map daily climate variables, including humidity, solar radiation, wind, precipitation, and temperature. We applied the method to the conterminous USA from 1980 to 2015. Previously, we successfully developed a precipitation interpolation method using random forest algorithm, and now we extended it to the other variables. Because this method does not require any assumptions about physical equations, this method can potentially be applicable to any climate variable if measured data are available. The method requires point data along with a host of spatial data sets . Satellite data, reanalysis data, and radar data were used and the importance of each dataset was analyzed using random forest algorithm. The only parameter we need to adjust is the radius from the target point, in which statistically meaningful relationships between observed and spatial co-variate data is calculated. The radius was optimized using mean absolute error and bias. We also analyzed temporal consistency and spatial patterns of the results. Because it is relatively easy to customize the setup depending on user's request, the resulting datasets may be useful for
Zhu, Xiang-Wei; Xin, Yan-Jun; Ge, Hui-Lin
2015-04-27
Variable selection is of crucial significance in QSAR modeling since it increases the model predictive ability and reduces noise. The selection of the right variables is far more complicated than the development of predictive models. In this study, eight continuous and categorical data sets were employed to explore the applicability of two distinct variable selection methods random forests (RF) and least absolute shrinkage and selection operator (LASSO). Variable selection was performed: (1) by using recursive random forests to rule out a quarter of the least important descriptors at each iteration and (2) by using LASSO modeling with 10-fold inner cross-validation to tune its penalty λ for each data set. Along with regular statistical parameters of model performance, we proposed the highest pairwise correlation rate, average pairwise Pearson's correlation coefficient, and Tanimoto coefficient to evaluate the optimal by RF and LASSO in an extensive way. Results showed that variable selection could allow a tremendous reduction of noisy descriptors (at most 96% with RF method in this study) and apparently enhance model's predictive performance as well. Furthermore, random forests showed property of gathering important predictors without restricting their pairwise correlation, which is contrary to LASSO. The mutual exclusion of highly correlated variables in LASSO modeling tends to skip important variables that are highly related to response endpoints and thus undermine the model's predictive performance. The optimal variables selected by RF share low similarity with those by LASSO (e.g., the Tanimoto coefficients were smaller than 0.20 in seven out of eight data sets). We found that the differences between RF and LASSO predictive performances mainly resulted from the variables selected by different strategies rather than the learning algorithms. Our study showed that the right selection of variables is more important than the learning algorithm for modeling. We hope
Are the Variability Properties of the Kepler AGN Light Curves Consistent with a Damped Random Walk?
Kasliwal, Vishal P.; Vogeley, Michael S.; Richards, Gordon T.
2015-01-01
We test the consistency of active galactic nuclei (AGN) optical flux variability with the $\\textit{damped random walk}$ (DRW) model. Our sample consists of 20 multi-quarter $\\textit{Kepler}$ AGN light curves including both Type 1 and 2 Seyferts, radio-loud and -quiet AGN, quasars, and blazars. $\\textit{Kepler}$ observations of AGN light curves offer a unique insight into the variability properties of AGN light curves because of the very rapid ($11.6-28.6$ min) and highly uniform rest-frame sa...
Seok Yoon Hwang; Dug Hun Hong
1999-01-01
LetÃ‚Â {Xij} be a double sequence of pairwise independent random variables.Ã‚Â IfÃ‚Â P{|Xmn|Ã¢Â‰Â¥t}Ã¢Â‰Â¤P{|X|Ã¢Â‰Â¥t} for all nonnegative real numbersÃ‚Â t and E|X|p(log+|X|)3
General Limit Distributions for Sums of Random Variables with a Matrix Product Representation
Angeletti, Florian; Bertin, Eric; Abry, Patrice
2014-12-01
The general limit distributions of the sum of random variables described by a finite matrix product ansatz are characterized. Using a mapping to a Hidden Markov Chain formalism, non-standard limit distributions are obtained, and related to a form of ergodicity breaking in the underlying non-homogeneous Hidden Markov Chain. The link between ergodicity and limit distributions is detailed and used to provide a full algorithmic characterization of the general limit distributions.
The probability distribution function for the sum of squares of independent random variables
Fateev, Yury; Dmitriev, Dmitry; Tyapkin, Valery; Kremez, Nikolai; Shaidurov, Vladimir
2016-08-01
In the present paper, the probability distribution function is derived for the sum of squares of random variables for nonzero expectations. This distribution function enables one to develop an efficient one-step algorithm for phase ambiguity resolution when determining the spatial orientation from signals of satellite radio-navigation systems. Threshold values for rejecting false solutions and statistical properties of the algorithm are obtained.
1999-01-01
Suppose X1,X2 are independent random variables satisfying a second-order regular variation condition on the tail-sum and a balance condition on the tails. In this paper we give a description of the asymptotic behaviour as t → ∞ for P(X1 + X2 > t). The result is applied to the problem of risk diversification in portfolio analysis and to the estimation of the parameter in a MA(1) model.
On Stein's method for products of normal random variables and zero bias couplings
Gaunt, Robert E.
2013-01-01
In this paper we extend Stein's method to the distribution of the product of $n$ independent mean zero normal random variables. A Stein equation is obtained for this class of distributions, which reduces to the classical normal Stein equation in the case $n=1$. This Stein equation motivates a generalisation of the zero bias transformation. We establish properties of this new transformation, and illustrate how they may be used together with the Stein equation to assess distributional distances...
Central limit theorems for directional and linear random variables with applications
García-Portugués, Eduardo; Crujeiras, Rosa M.; González-Manteiga, Wenceslao
2014-01-01
A central limit theorem for the integrated squared error of the directional-linear kernel density estimator is established. The result enables the construction and analysis of two testing procedures based on squared loss: a nonparametric independence test for directional and linear random variables and a goodness-of-fit test for parametric families of directional-linear densities. Limit distributions for both test statistics, and a consistent bootstrap strategy for the goodness-of-fit test, a...
Autoclassification of the Variable 3XMM Sources Using the Random Forest Machine Learning Algorithm
Farrell, Sean A.; Murphy, Tara; Lo, Kitty K.
2015-11-01
In the current era of large surveys and massive data sets, autoclassification of astrophysical sources using intelligent algorithms is becoming increasingly important. In this paper we present the catalog of variable sources in the Third XMM-Newton Serendipitous Source catalog (3XMM) autoclassified using the Random Forest machine learning algorithm. We used a sample of manually classified variable sources from the second data release of the XMM-Newton catalogs (2XMMi-DR2) to train the classifier, obtaining an accuracy of ∼92%. We also evaluated the effectiveness of identifying spurious detections using a sample of spurious sources, achieving an accuracy of ∼95%. Manual investigation of a random sample of classified sources confirmed these accuracy levels and showed that the Random Forest machine learning algorithm is highly effective at automatically classifying 3XMM sources. Here we present the catalog of classified 3XMM variable sources. We also present three previously unidentified unusual sources that were flagged as outlier sources by the algorithm: a new candidate supergiant fast X-ray transient, a 400 s X-ray pulsar, and an eclipsing 5 hr binary system coincident with a known Cepheid.
Extended q -Gaussian and q -exponential distributions from gamma random variables
Budini, Adrián A.
2015-05-01
The family of q -Gaussian and q -exponential probability densities fit the statistical behavior of diverse complex self-similar nonequilibrium systems. These distributions, independently of the underlying dynamics, can rigorously be obtained by maximizing Tsallis "nonextensive" entropy under appropriate constraints, as well as from superstatistical models. In this paper we provide an alternative and complementary scheme for deriving these objects. We show that q -Gaussian and q -exponential random variables can always be expressed as a function of two statistically independent gamma random variables with the same scale parameter. Their shape index determines the complexity q parameter. This result also allows us to define an extended family of asymmetric q -Gaussian and modified q -exponential densities, which reduce to the standard ones when the shape parameters are the same. Furthermore, we demonstrate that a simple change of variables always allows relating any of these distributions with a beta stochastic variable. The extended distributions are applied in the statistical description of different complex dynamics such as log-return signals in financial markets and motion of point defects in a fluid flow.
Measures of between-cluster variability in cluster randomized trials with binary outcomes.
Thomson, Andrew; Hayes, Richard; Cousens, Simon
2009-05-30
Cluster randomized trials (CRTs) are increasingly used to evaluate the effectiveness of health-care interventions. A key feature of CRTs is that the observations on individuals within clusters are correlated as a result of between-cluster variability. Sample size formulae exist which account for such correlations, but they make different assumptions regarding the between-cluster variability in the intervention arm of a trial, resulting in different sample size estimates. We explore the relationship for binary outcome data between two common measures of between-cluster variability: k, the coefficient of variation and rho, the intracluster correlation coefficient. We then assess how the assumptions of constant k or rho across treatment arms correspond to different assumptions about intervention effects. We assess implications for sample size estimation and present a simple solution to the problems outlined. PMID:19378266
St. Martin, Clara M.; Lundquist, Julie K.; Handschy, Mark A.
2015-04-01
The variability in wind-generated electricity complicates the integration of this electricity into the electrical grid. This challenge steepens as the percentage of renewably-generated electricity on the grid grows, but variability can be reduced by exploiting geographic diversity: correlations between wind farms decrease as the separation between wind farms increases. But how far is far enough to reduce variability? Grid management requires balancing production on various timescales, and so consideration of correlations reflective of those timescales can guide the appropriate spatial scales of geographic diversity grid integration. To answer ‘how far is far enough,’ we investigate the universal behavior of geographic diversity by exploring wind-speed correlations using three extensive datasets spanning continents, durations and time resolution. First, one year of five-minute wind power generation data from 29 wind farms span 1270 km across Southeastern Australia (Australian Energy Market Operator). Second, 45 years of hourly 10 m wind-speeds from 117 stations span 5000 km across Canada (National Climate Data Archive of Environment Canada). Finally, four years of five-minute wind-speeds from 14 meteorological towers span 350 km of the Northwestern US (Bonneville Power Administration). After removing diurnal cycles and seasonal trends from all datasets, we investigate dependence of correlation length on time scale by digitally high-pass filtering the data on 0.25-2000 h timescales and calculating correlations between sites for each high-pass filter cut-off. Correlations fall to zero with increasing station separation distance, but the characteristic correlation length varies with the high-pass filter applied: the higher the cut-off frequency, the smaller the station separation required to achieve de-correlation. Remarkable similarities between these three datasets reveal behavior that, if universal, could be particularly useful for grid management. For high
Directory of Open Access Journals (Sweden)
Correchel Vladia
2005-01-01
Full Text Available The precision of the 137Cs fallout redistribution technique for the evaluation of soil erosion rates is strongly dependent on the quality of an average inventory taken at a representative reference site. The knowledge of the sources and of the degree of variation of the 137Cs fallout spatial distribution plays an important role on its use. Four reference sites were selected in the South-Central region of Brazil which were characterized in terms of soil chemical, physical and mineralogical aspects as well as the spatial variability of 137Cs inventories. Some important differences in the patterns of 137Cs depth distribution in the soil profiles of the different sites were found. They are probably associated to chemical, physical, mineralogical and biological differences of the soils but many questions still remain open for future investigation, mainly those regarding the adsorption and dynamics of the 137Cs ions in soil profiles under tropical conditions. The random spatial variability (inside each reference site was higher than the systematic spatial variability (between reference sites but their causes were not clearly identified as possible consequences of chemical, physical, mineralogical variability, and/or precipitation.
Institute of Scientific and Technical Information of China (English)
无
2010-01-01
To analyze the effect of basic variable on failure probability in reliability analysis,a moment-independent importance measure of the basic random variable is proposed,and its properties are analyzed and verified.Based on this work,the importance measure of the basic variable on the failure probability is compared with that on the distribution density of the response.By use of the probability density evolution method,a solution is established to solve two importance measures,which can efficiently avoid the difficulty in solving the importance measures.Some numerical examples and engineering examples are used to demonstrate the proposed importance measure on the failure probability and that on the distribution density of the response.The results show that the proposed importance measure can effectively describe the effect of the basic variable on the failure probability from the distribution density of the basic variable.Additionally,the results show that the established solution on the probability density evolution is efficient for the importance measures.
Blind estimation of statistical properties of non-stationary random variables
Mansour, Ali; Mesleh, Raed; Aggoune, el-Hadi M.
2014-12-01
To identify or equalize wireless transmission channels, or alternatively to evaluate the performance of many wireless communication algorithms, coefficients or statistical properties of the used transmission channels are often assumed to be known or can be estimated at the receiver end. For most of the proposed algorithms, the knowledge of transmission channel statistical properties is essential to detect signals and retrieve data. To the best of our knowledge, most proposed approaches assume that transmission channels are static and can be modeled by stationary random variables (uniform, Gaussian, exponential, Weilbul, Rayleigh, etc.). In the majority of sensor networks or cellular systems applications, transmitters and/or receivers are in motion. Therefore, the validity of static transmission channels and the underlying assumptions may not be valid. In this case, coefficients and statistical properties change and therefore the stationary model falls short of making an accurate representation. In order to estimate the statistical properties (represented by the high-order statistics and probability density function, PDF) of dynamic channels, we firstly assume that the dynamic channels can be modeled by short-term stationary but long-term non-stationary random variable (RV), i.e., the RVs are stationary within unknown successive periods but they may suddenly change their statistical properties between two successive periods. Therefore, this manuscript proposes an algorithm to detect the transition phases of non-stationary random variables and introduces an indicator based on high-order statistics for non-stationary transmission which can be used to alter channel properties and initiate the estimation process. Additionally, PDF estimators based on kernel functions are also developed. The first part of the manuscript provides a brief introduction for unbiased estimators of the second and fourth-order cumulants. Then, the non-stationary indicators are formulated
Records and sequences of records from random variables with a linear trend
Franke, Jasper; Wergen, Gregor; Krug, Joachim
2010-01-01
We consider records and sequences of records drawn from discrete time series of the form $X_{n}=Y_{n}+cn$, where the $Y_{n}$ are independent and identically distributed random variables and $c$ is a constant drift. For very small and very large drift velocities, we investigate the asymptotic behavior of the probability $p_n(c)$ of a record occurring in the $n$th step and the probability $P_N(c)$ that all $N$ entries are records, i.e. that $X_1 < X_2 < ... < X_N$. Our work is motivated by the ...
Genuer, Robin; Toussile, Wilson
2011-01-01
Malaria control strategies aiming at reducing disease transmission intensity may impact both oocyst intensity and infection prevalence in the mosquito vector. Thus far, mathematical models failed to identify a clear relationship between Plasmodium falciparum gametocytes and their infectiousness to mosquitoes. Natural isolates of gametocytes are genetically diverse and biologically complex. Infectiousness to mosquitoes relies on multiple parameters such as density, sex-ratio, maturity, parasite genotypes and host immune factors. In this article, we investigated how density and genetic diversity of gametocytes impact on the success of transmission in the mosquito vector. We analyzed data for which the number of covariates plus attendant interactions is at least of order of the sample size, precluding usage of classical models such as general linear models. We then considered the variable importance from random forests to address the problem of selecting the most influent variables. The selected covariates were ...
Latitudinal dependence of the variability of the micrometeor altitude distribution
Sparks, J. J.; Janches, D.
2009-06-01
We present a study of the diurnal behavior of the observed meteor altitude distribution at different seasons and latitudes. The meteor altitude distribution provides an indication of where the meteoric mass deposition occurs in the mesosphere and lower thermosphere (MLT). This can be utilized to model the input of metallic constituents into the MLT and accurately understand the chemistry of this region. We show that the observed altitude distributions have distinct variability at each location: at high latitudes there is a weak diurnal and strong seasonal variability while at tropical latitudes the opposite behavior is observed. We explain these results by correlating them with the astronomical and physical properties of the meteoric flux. Finally, we discussed the potential influences that these results have on the metal chemistry and aeronomy of this atmospheric region.
The Energy Dependence of GRB Minimum Variability Timescales
Golkhou, V. Zach; Butler, Nathaniel R.; Littlejohns, Owen M.
2015-10-01
We constrain the minimum variability timescales for 938 gamma-ray bursts (GRBs) observed by the Fermi/Gamma-ray Burst Monitor instrument prior to 2012 July 11. The tightest constraints on progenitor radii derived from these timescales are obtained from light curves in the hardest energy channel. In the softer bands—or from measurements of the same GRBs in the hard X-rays from Swift—we show that variability timescales tend to be a factor of two to three longer. Applying a survival analysis to account for detections and upper limits, we find median minimum timescale in the rest frame for long-duration and short-duration GRBs of 45 and 10 ms, respectively. Less than 10% of GRBs show evidence for variability on timescales below 2 ms. These shortest timescales require Lorentz factors ≳ 400 and imply typical emission radii R≈ 1× {10}14 cm for long-duration GRBs and R≈ 3× {10}13 cm for short-duration GRBs. We discuss implications for the GRB fireball model and investigate whether or not GRB minimum timescales evolve with cosmic time.
The Energy-Dependence of GRB Minimum Variability Timescales
Golkhou, V Zach; Littlejohns, Owen M
2015-01-01
We constrain the minimum variability timescales for 938 GRBs observed by the Fermi/GBM instrument prior to July 11, 2012. The tightest constraints on progenitor radii derived from these timescales are obtained from light curves in the hardest energy channel. In the softer bands -- or from measurements of the same GRBs in the hard X-rays from Swift -- we show that variability timescales tend to be a factor 2--3 longer. Applying a survival analysis to account for detections and upper limits, we find median minimum timescale in the rest frame for long-duration and short-duration GRBs of 45 ms and 10 ms, respectively. Fewer than 10% of GRBs show evidence for variability on timescales below 2 ms. These shortest timescales require Lorentz factors $\\gtrsim 400$ and imply typical emission radii $R \\approx 1 {\\times} 10^{14}$ cm for long-duration GRBs and $R \\approx 3 {\\times} 10^{13}$ cm for short-duration GRBs. We discuss implications for the GRB fireball model and investigate whether GRB minimum timescales evolve w...
Nutrition education intervention for dependent patients: protocol of a randomized controlled trial
Arija Victoria; Martín Núria; Canela Teresa; Anguera Carme; Castelao Ana I; García-Barco Montserrat; García-Campo Antoni; González-Bravo Ana I; Lucena Carme; Martínez Teresa; Fernández-Barrés Silvia; Pedret Roser; Badia Waleska; Basora Josep
2012-01-01
Abstract Background Malnutrition in dependent patients has a high prevalence and can influence the prognosis associated with diverse pathologic processes, decrease quality of life, and increase morbidity-mortality and hospital admissions. The aim of the study is to assess the effect of an educational intervention for caregivers on the nutritional status of dependent patients at risk of malnutrition. Methods/Design Intervention study with control group, randomly allocated, of 200 patients of t...
van der Zwan, Judith Esi; de Vente, Wieke; Huizink, Anja C; Bögels, Susan M; de Bruin, Esther I
2015-12-01
In contemporary western societies stress is highly prevalent, therefore the need for stress-reducing methods is great. This randomized controlled trial compared the efficacy of self-help physical activity (PA), mindfulness meditation (MM), and heart rate variability biofeedback (HRV-BF) in reducing stress and its related symptoms. We randomly allocated 126 participants to PA, MM, or HRV-BF upon enrollment, of whom 76 agreed to participate. The interventions consisted of psycho-education and an introduction to the specific intervention techniques and 5 weeks of daily exercises at home. The PA exercises consisted of a vigorous-intensity activity of free choice. The MM exercises consisted of guided mindfulness meditation. The HRV-BF exercises consisted of slow breathing with a heart rate variability biofeedback device. Participants received daily reminders for their exercises and were contacted weekly to monitor their progress. They completed questionnaires prior to, directly after, and 6 weeks after the intervention. Results indicated an overall beneficial effect consisting of reduced stress, anxiety and depressive symptoms, and improved psychological well-being and sleep quality. No significant between-intervention effect was found, suggesting that PA, MM, and HRV-BF are equally effective in reducing stress and its related symptoms. These self-help interventions provide easily accessible help for people with stress complaints. PMID:26111942
Brief Treatments for Cannabis Dependence: Findings From a Randomized Multisite Trial
Babor, Thomas F.
2004-01-01
This study evaluated the efficacy of 2 brief interventions for cannabis-dependent adults. A multisite randomized controlled trial compared cannabis use outcomes across 3 study conditions: (a) 2 sessions of motivational enhancement therapy (MET); (b) 9 sessions of multicomponent therapy that included MET, cognitive-behavioral therapy, and case…
Measures of dependence between random vectors and tests of independence. Literature review
Josse, Julie; Holmes, Susan
2013-01-01
Simple correlation coefficients between two variables have been generalized to measure association between two matrices in many ways. Coefficients such as the RV coefficient, the distance covariance (dCov) coefficient and kernel based coefficients have been adopted by different research communities. Scientists use these coefficients to test whether two random vectors are linked. If they are, it is important to uncover what patterns exist in these associations. We discuss the topic of measures...
Lloret Cabot, M.; Hicks, M. A.; van den Eijnden, A. P.
2012-01-01
Spatial variability of soil properties is inherent in soil deposits, whether as a result of natural geological processes or engineering construction. It is therefore important to account for soil variability in geotechnical design in order to represent more realistically a soil’s in situ state. This variability may be modelled as a random field, with a given probability density function and scale of fluctuation. A more convenient way to deal with the uncertainty of a soil property due to spat...
Energy decay of a variable-coefficient wave equation with nonlinear time-dependent localized damping
Directory of Open Access Journals (Sweden)
Jieqiong Wu
2015-09-01
Full Text Available We study the energy decay for the Cauchy problem of the wave equation with nonlinear time-dependent and space-dependent damping. The damping is localized in a bounded domain and near infinity, and the principal part of the wave equation has a variable-coefficient. We apply the multiplier method for variable-coefficient equations, and obtain an energy decay that depends on the property of the coefficient of the damping term.
Age-dependence and intersubject variability of tracheobronchial particle clearance
Directory of Open Access Journals (Sweden)
Robert Sturm
2011-01-01
Full Text Available SUMMARY.Background: The detailed study of tracheobronchial clearanceof inhaled particles represents one of the basic research questionsin lung medicine. The clearance efficiency varies in different agegroups and between males and females.The differences can bepartly clarified by the application of a well validated theoreticalapproach. This study applied a relevant model to children (1 year,5 years, 10 years, juveniles (15 years, and adults of different ages(18, 21, 25, 34, 50, and 60 years and to both sexes. Methods: Themathematical model used for clearance simulation is based on theconcept of a stochastic lung structure and considers both early fastmucociliary clearance and a later, slow clearance fraction, fs, effectedby particular uptake by tracheobronchial cells, e.g., macrophagesand epithelial cells. According to this model, the calculated mucusvelocities for each airway generation of the tracheobronchial compartmentare normalized to a respective tracheal mucus velocitythat is estimated for each of the age groups studied from an allometricfunction. Results: In general, tracheobronchial clearanceefficiency undergoes a significant increase from childhood to youngadulthood, reaching a maximum at 25-30 years and decreasingagain from about 30 years to 60 years. Conversely to the improvementof clearance, the continuous change of airway morphometrywith increasing age causes a decrease of the filtering effect in thetrachea and main bronchi, which is of marked importance in infants.The modelling results demonstrate differences in tracheobronchialclearance between males and females, generally in the range from0 to 5%, which are exclusively determined by the individual lunggeometry. Conclusions: Based on theoretical computations itcan be concluded that tracheobronchial clearance is a phenomenonthat depends on both age and sex. Biological studies are necessaryto determine the cellular and molecular mechanisms underlyingthe age-dependent development of
A Random Variable Substitution Lemma With Applications to Multiple Description Coding
Wang, Jia; Zhao, Lei; Cuff, Paul; Permuter, Haim
2009-01-01
We establish a random variable substitution lemma and use it to investigate the role of refinement layer in multiple description coding, which clarifies the relationship among several existing achievable multiple description rate-distortion regions. Specifically, it is shown that the El Gamal-Cover (EGC) region is equivalent to the EGC* region (an antecedent version of the EGC region) while the Venkataramani-Kramer-Goyal (VKG) region (when specialized to the 2-description case) is equivalent to the Zhang-Berger (ZB) region. Moreover, we prove that for multiple description coding with individual and hierarchical distortion constraints, the number of layers in the VKG scheme can be significantly reduced when only certain weighted sum rates are concerned. The role of refinement layer in scalable coding (a special case of multiple description coding) is also studied.
Directory of Open Access Journals (Sweden)
Tyson H Holmes
2011-07-01
Full Text Available The HIV risk-taking behavior scale (HRBS is an 11-item instrument designed to assess the risks of HIV infection due self-reported injection drug use and sexual behavior. A retrospective analysis was performed on HRBS data collected from approximately 1,000 participants pooled across seven clinical trials of pharmacotherapies for either the treatment of cocaine-dependence or methamphetamine-dependence. Analysis faced three important challenges. The sample contained a high proportion of missing assessments after randomization. Also, the HRBS scale consists of two distinct behavioral components which may or may not coincide in response patterns. In addition, distributions of responses on the subscales were highly concentrated at just a few values (e.g., 0, 6. To address these challenges, a single probit regression model was fit to three outcomes variables simultaneously—the two subscale totals plus an indicator variable for assessments not obtained (non-response. This joint-outcome regression model was able to identify that those who left assessment early had higher self-reported risk of injection-drug use and lower self-reported risky sexual behavior because the model was able to draw on information on associations among the three outcomes collectively. These findings were not identified in analyses performed on each outcome separately. No evidence for an effect of pharmacotherapies was observed, except to reduce missing assessments. Univariate-outcome modeling is not recommended for the HRBS.
Institute of Scientific and Technical Information of China (English)
无
2002-01-01
Objective To design and develop a novel, sensitive and versatile method for in vivo foot printing and studies of DNA damage, such as DNA adducts and strand breaks. Methods Starting with mammalian genomic DNA, single-stranded products were made by repeated primer extension, these products were ligated to a double-stranded linker having a randomized 3′ overhang, and used for PCR.DNA breaks in p53 gene produced by restriction endonuclease AfaI were detected by using this new method followed by Southern hybridization with DIG-labeled probe. Results This randomized terminal linker-dependent PCR (RDPCR) method could generate band signals many-fold stronger than conventional ligation-mediated PCR (LMPCR), and it was more rapid, convenient and accurate than the terminal transferase-dependent PCR (TDPCR). Conclusion DNA strand breakage can be detected sensitively in the gene level by RDPCR. Any lesion that blocks primer extension should be detectable.
Are the Variability Properties of the Kepler AGN Light Curves Consistent with a Damped Random Walk?
Kasliwal, Vishal P; Richards, Gordon T
2015-01-01
We test the consistency of active galactic nuclei (AGN) optical flux variability with the \\textit{damped random walk} (DRW) model. Our sample consists of 20 multi-quarter \\textit{Kepler} AGN light curves including both Type 1 and 2 Seyferts, radio-loud and -quiet AGN, quasars, and blazars. \\textit{Kepler} observations of AGN light curves offer a unique insight into the variability properties of AGN light curves because of the very rapid ($11.6-28.6$ min) and highly uniform rest-frame sampling combined with a photometric precision of $1$ part in $10^{5}$ over a period of 3.5 yr. We categorize the light curves of all 20 objects based on visual similarities and find that the light curves fall into 5 broad categories. We measure the first order structure function of these light curves and model the observed light curve with a general broken power-law PSD characterized by a short-timescale power-law index $\\gamma$ and turnover timescale $\\tau$. We find that less than half the objects are consistent with a DRW and ...
Institute of Scientific and Technical Information of China (English)
LIU Hai; LIU JinSong; L(U) JianTao; WANG KeJia
2009-01-01
Polarization-dependent difference of the power spectra from a set of two-dimensional (2D) passive random media is investigated by simultaneously solving Maxwell's equations for both transverse magnetic (TM) and transverse electric (TE) fields. The random media have the same random constitution but different shapes. Results show that both two polarized states are morphology dependent,and the variety of the shapes has more influence on the selection of TM polarized modes than that of TE polarized modes. Such polarization-dependent difference of morphology property presents a new modeselecting technique for random lasers.
Neto, Elias Chaibub; Bot, Brian M.; Kellen, Mike; Friend, Stephen H; Trister, Andrew D.
2016-01-01
Mobile health studies can leverage longitudinal sensor data from smartphones to guide the application of personalized medical interventions. These studies are particularly appealing due to their ability to attract a large number of participants. In this paper, we argue that the adoption of an instrumental variable approach for randomized trials with imperfect compliance provides a natural framework for personalized causal inference of medication response in mobile health studies. Randomized t...
Kaspar, H.; Newsbaum, J. B.
1967-01-01
Relationships between independent and dependent variables are determined by multiple correlation computer program. This is applied to research and experimental design and development of complex hardware and components that require test programs.
Dhingra, R. R.; Jacono, F. J.; Fishman, M; Loparo, K. A.; Rybak, I. A.; Dick, T E
2011-01-01
Physiological rhythms, including respiration, exhibit endogenous variability associated with health, and deviations from this are associated with disease. Specific changes in the linear and nonlinear sources of breathing variability have not been investigated. In this study, we used information theory-based techniques, combined with surrogate data testing, to quantify and characterize the vagal-dependent nonlinear pattern variability in urethane-anesthetized, spontaneously breathing adult rat...
Diffusion in time-dependent random environments: mass fluctuations and scaling properties
International Nuclear Information System (INIS)
A mass-ejection model in a time-dependent random environment with both temporal and spatial correlations is introduced. When the environment has a finite correlation length, individual particle trajectories are found to diffuse at large times with a displacement distribution that approaches a Gaussian. The collective dynamics of diffusing particles reaches a statistically stationary state, which is characterized in terms of a fluctuating mass density field. The probability distribution of density is studied numerically for both smooth and non-smooth scale-invariant random environments. Competition between trapping in the regions where the ejection rate of the environment vanishes and mixing due to its temporal dependence leads to large fluctuations of mass. These mechanisms are found to result in the presence of intermediate power-law tails in the probability distribution of the mass density. For spatially differentiable environments, the exponent of the right tail is shown to be universal and equal to -3/2. However, at small values, it is found to depend on the environment. Finally, spatial scaling properties of the mass distribution are investigated. The distribution of the coarse-grained density is shown to possess some rescaling properties that depend on the scale, the amplitude of the ejection rate and the Hölder exponent of the environment. (paper)
Vardeman, Stephen B.; Wendelberger, Joanne R.
2003-01-01
There is a little-known but very simple generalization of the standard result that for uncorrelated variables with a common mean and variance, the expected sample variance is the marginal variance. The generalization justifies the use of the usual standard error of the sample mean in possibly heteroscedastic situations and motivates some simple estimators for unbalanced linear random effects models. The latter is illustrated for the simple one-way context.
Directory of Open Access Journals (Sweden)
Anita Sharma
2011-01-01
Full Text Available Blinking statistics of quantum dot has attracted much attraction in recent years. Various experiments were conducted and various theories have been given to explain this phenomenon. However, the problem is not yet resolved. The weak temperature dependence of the power law parameters have complicated the phenomena. We have simulated the blinking statistics of quantum dot based on the random walk model. We have shown that three-dimensional biased Levy random walk of electrons, the bias being the Columbic interaction between electrons and ionized atoms can explain the observed experimental results. We have simulated the blinking properties of quantum dots in a broad temperature range (10-300 K. The distributions exhibit power law behavior for a wide range of temperature, but the power law parameter increases marginally with temperature. The trend of change is independent of the size of the quantum dots as confirmed from the simulation.
Bell-Boole Inequality: Nonlocality or Probabilistic Incompatibility of Random Variables?
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Andrei Khrennikov
2008-03-01
Full Text Available The main aim of this report is to inform the quantum information community about investigations on the problem of probabilistic compatibility of a family of random variables: a possibility to realize such a family on the basis of a single probability measure (to construct a single Kolmogorov probability space. These investigations were started hundred of years ago by J. Boole (who invented Boolean algebras. The complete solution of the problem was obtained by Soviet mathematician Vorobjev in 60th. Surprisingly probabilists and statisticians obtained inequalities for probabilities and correlations among which one can find the famous BellÃ¢Â€Â™s inequality and its generalizations. Such inequalities appeared simply as constraints for probabilistic compatibility. In this framework one can not see a priori any link to such problems as nonlocality and Ã¢Â€Âœdeath of realityÃ¢Â€Â which are typically linked to BellÃ¢Â€Â™s type inequalities in physical literature. We analyze the difference between positions of mathematicians and quantum physicists. In particular, we found that one of the most reasonable explanations of probabilistic incompatibility is mixing in BellÃ¢Â€Â™s type inequalities statistical data from a number of experiments performed under different experimental contexts.
Directory of Open Access Journals (Sweden)
K.Manikandan
2011-02-01
Full Text Available The Wide-expansion of mobile telecommunication technology mobile banking emerged as a new type of financial services and can provide efficient and effective financial services for clients. Mobile banking is a way for the customer to perform banking actions on his or her cell phone or other mobile device. It is a quite popular method of banking that fits in well with a busy, technologically oriented lifestyle. Framework conditions for mobile banking services differ from country to country but one thing is certain: the future of mobile banking depends on getting the security right. In this paper, we present a new way of securing mobile banking. We introduce a system which makes use of Elliptic curve cryptography and RGB Intensity Based Randomized pixels with variable Bits image Steganography [5]. Elliptic Curve Cryptography suites well for resources constraint devices like mobile phones and PDA, because of its less computation time, short key’s length, fast digital signature, flexibility and less resource consumption
International Nuclear Information System (INIS)
A new reliability measure is proposed and equations are derived which determine the probability of existence of a specified set of minimum gaps between random variables following a homogeneous Poisson process in a finite interval. Using the derived equations, a method is proposed for specifying the upper bound of the random variables' number density which guarantees that the probability of clustering of two or more random variables in a finite interval remains below a maximum acceptable level. It is demonstrated that even for moderate number densities the probability of clustering is substantial and should not be neglected in reliability calculations. In the important special case where the random variables are failure times, models have been proposed for determining the upper bound of the hazard rate which guarantees a set of minimum failure-free operating intervals before the random failures, with a specified probability. A model has also been proposed for determining the upper bound of the hazard rate which guarantees a minimum availability target. Using the models proposed, a new strategy, models and reliability tools have been developed for setting quantitative reliability requirements which consist of determining the intersection of the hazard rate envelopes (hazard rate upper bounds) which deliver a minimum failure-free operating period before random failures, a risk of premature failure below a maximum acceptable level and a minimum required availability. It is demonstrated that setting reliability requirements solely based on an availability target does not necessarily mean a low risk of premature failure. Even at a high availability level, the probability of premature failure can be substantial. For industries characterised by a high cost of failure, the reliability requirements should involve a hazard rate envelope limiting the risk of failure below a maximum acceptable level
Cryptography based on chaotic random maps with position dependent weighting probabilities
International Nuclear Information System (INIS)
Chaotic cryptology has been widely investigated recently. A common feature in the most recent developments of chaotic cryptosystems is the use of a single dynamical rule in the encoding-decoding process. The main objective of this paper is to provide a set of chaotic systems instead of a single one for cryptography. In this paper, we introduce a chaotic cryptosystem based on the symbolic dynamics of random maps with position dependent weighting probabilities. The random maps model is a deterministic dynamical system in a finite phase space with n points. The maps that establish the dynamics of the system are chosen randomly for every point. The essential idea of this paper is that, given two dynamical systems that behave in a certain way, it is possible to combine them (by composing) into a new dynamical system. This dynamically composed system behaves in a completely different way compared to the constituent systems. The proposed scheme exploits the symbolic dynamics of a set of chaotic maps in order to encode the binary information. The performance of the new cryptosystem based on chaotic dynamical systems properties is examined. Both theoretical and experimental results demonstrate that the proposed algorithm using symbolic dynamics achieves the optimal security criteria.
Quantum treatment of the time-dependent coupled oscillators under the action of a random force
International Nuclear Information System (INIS)
In this communication we introduce the problem of time-dependent frequency converter under the action of external random force. We have assumed that the coupling parameter and the phase pump are explicitly time dependent. Using the equations of motion in the Heisenberg picture the dynamical operators are obtained, however, under a certain integrability condition. When the system is initially prepared in the even coherent states the squeezing phenomenon is discussed. The correlation function is also considered and it has been shown that the nonclassical properties are apparent and sensitive to any variation in the integrability parameter. Furthermore, the wave function in Schroedinger picture is calculated and used it to derive the wave function in the coherent states. The accurate definition of the creation and annihilation operators are also introduced and employed to diagonalize the Hamiltonian system
Large Deviations for Sums of Heavy-tailed Random Variables%重尾随机变量和的大偏差
Institute of Scientific and Technical Information of China (English)
郭晓燕; 孔繁超
2007-01-01
This paper is a further investigation of large deviations for sums of random variables Sn =n∑i=1 Xi and S(t)=N(t)∑i=1 Xi,(t≥0), where {Xn,n≥1} are independent identically distribution and non-negative random variables, and {N(t),t≥0} is a counting process of non-negative integer-valued random variables, independent of {Xn,n≥1}. In this paper, under the suppose F ∈G, which is a bigger heavy-tailed class than C, proved large deviation results for sums of random variables.
Directory of Open Access Journals (Sweden)
Seok Yoon Hwang
1999-03-01
Full Text Available LetÃ‚Â {Xij} be a double sequence of pairwise independent random variables.Ã‚Â IfÃ‚Â P{|Xmn|Ã¢Â‰Â¥t}Ã¢Â‰Â¤P{|X|Ã¢Â‰Â¥t} for all nonnegative real numbersÃ‚Â t and E|X|p(log+|X|3<Ã¢ÂˆÂž, for 1
random variables under the conditions E|X|p(log+|X|r+1<Ã¢ÂˆÂž,E|X|p(log+|X|rÃ¢ÂˆÂ’1<Ã¢ÂˆÂž, respectively, thus, extending Choi and Sung's result [1] of the one-dimensional case.
Homogenization for rigid suspensions with random velocity-dependent interfacial forces
Gorb, Yuliya
2014-12-01
We study suspensions of solid particles in a viscous incompressible fluid in the presence of random velocity-dependent interfacial forces. The flow at a small Reynolds number is modeled by the Stokes equations, coupled with the motion of rigid particles arranged in a periodic array. The objective is to perform homogenization for the given suspension and obtain an equivalent description of a homogeneous (effective) medium, the macroscopic effect of the interfacial forces and the effective viscosity are determined using the analysis on a periodicity cell. In particular, the solutions uωε to a family of problems corresponding to the size of microstructure ε and describing suspensions of rigid particles with random surface forces imposed on the interface, converge H1-weakly as ε→0 a.s. to a solution of a Stokes homogenized problem, with velocity dependent body forces. A corrector to a homogenized solution that yields a strong H1-convergence is also determined. The main technical construction is built upon the Γ-convergence theory. © 2014 Elsevier Inc.
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DIYAH MARTANTI
2008-10-01
Full Text Available Amorphophallus muelleri Blume (Araceae is valued for its glucomanan content for use in food industry (healthy diet food, paper industry, pharmacy and cosmetics. The species is triploid (2n=3x=39 and the seed is developed apomictically. The present research is aimed to identify genetic variability of six population of A. muelleri from Java (consisted of 50 accessions using random amplified polymorphic DNA (RAPD. The six populations of the species are: East Java: (1 Silo-Jember, (2 Saradan-Madiun, (3 IPB (cultivated, from Saradan-Madiun, (4 Panti-Jember, (5 Probolinggo; and Central Java: (6 Cilacap. The results showed that five RAPD primers generated 42 scorable bands of which 29 (69.05% were polymorphic. Size of the bands varied from 300bp to 1.5kbp. The 50 accessions of A. muelleri were divided into two main clusters, some of them were grouped based on their populations, and some others were not. The range of individual genetic dissimilarity was from 0.02 to 0.36. The results showed that among six populations investigated, Saradan population showed the highest levels of genetic variation with mean values of na = 1.500+ 0.5061, ne = 1.3174 + 0.3841, PLP = 50% and He = 0, 0.1832+0.2054, whereas Silo-Jember population showed the lowest levels of genetic variation with mean values na = 1.2619+ 0.4450, ne = 1.1890 + 0.3507, PLP = 26.19% and He = 0.1048+0.1887. Efforts to conserve, domesticate, cultivate and improve genetically should be based on the genetic properties of each population and individual within population, especially Saradan population which has the highest levels of genetic variation, need more attention for its conservation.
A WntD-Dependent Integral Feedback Loop Attenuates Variability in Drosophila Toll Signaling.
Rahimi, Neta; Averbukh, Inna; Haskel-Ittah, Michal; Degani, Neta; Schejter, Eyal D; Barkai, Naama; Shilo, Ben-Zion
2016-02-22
Patterning by morphogen gradients relies on the capacity to generate reproducible distribution profiles. Morphogen spread depends on kinetic parameters, including diffusion and degradation rates, which vary between embryos, raising the question of how variability is controlled. We examined this in the context of Toll-dependent dorsoventral (DV) patterning of the Drosophila embryo. We find that low embryo-to-embryo variability in DV patterning relies on wntD, a Toll-target gene expressed initially at the posterior pole. WntD protein is secreted and disperses in the extracellular milieu, associates with its receptor Frizzled4, and inhibits the Toll pathway by blocking the Toll extracellular domain. Mathematical modeling predicts that WntD accumulates until the Toll gradient narrows to its desired spread, and we support this feedback experimentally. This circuit exemplifies a broadly applicable induction-contraction mechanism, which reduces patterning variability through a restricted morphogen-dependent expression of a secreted diffusible inhibitor. PMID:26906736
Nutrition education intervention for dependent patients: protocol of a randomized controlled trial
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Arija Victoria
2012-05-01
Full Text Available Abstract Background Malnutrition in dependent patients has a high prevalence and can influence the prognosis associated with diverse pathologic processes, decrease quality of life, and increase morbidity-mortality and hospital admissions. The aim of the study is to assess the effect of an educational intervention for caregivers on the nutritional status of dependent patients at risk of malnutrition. Methods/Design Intervention study with control group, randomly allocated, of 200 patients of the Home Care Program carried out in 8 Primary Care Centers (Spain. These patients are dependent and at risk of malnutrition, older than 65, and have caregivers. The socioeconomic and educational characteristics of the patient and the caregiver are recorded. On a schedule of 0–6–12 months, patients are evaluated as follows: Mini Nutritional Assessment (MNA, food intake, dentures, degree of dependency (Barthel test, cognitive state (Pfeiffer test, mood status (Yesavage test, and anthropometric and serum parameters of nutritional status: albumin, prealbumin, transferrin, haemoglobin, lymphocyte count, iron, and ferritin. Prior to the intervention, the educational procedure and the design of educational material are standardized among nurses. The nurses conduct an initial session for caregivers and then monitor the education impact at home every month (4 visits up to 6 months. The North American Nursing Diagnosis Association (NANDA methodology will be used. The investigators will study the effect of the intervention with caregivers on the patient’s nutritional status using the MNA test, diet, anthropometry, and biochemical parameters. Bivariate normal test statistics and multivariate models will be created to adjust the effect of the intervention. The SPSS/PC program will be used for statistical analysis. Discussion The nutritional status of dependent patients has been little studied. This study allows us to know nutritional risk from different points of
On the dependence of QCD splitting functions on the choice of the evolution variable
Jadach, S; Placzek, W; Skrzypek, M
2016-01-01
We show that already at the NLO level the DGLAP evolution kernel Pqq starts to depend on the choice of the evolution variable. We give an explicit example of such a variable, namely the maximum of transverse momenta of emitted partons and we identify a class of evolution variables that leave the NLO Pqq kernel unchanged with respect to the known standard MS-bar results. The kernels are calculated using a modified Curci-Furmanski-Petronzio method which is based on a direct Feynman-graphs calculation.
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Janssen Patricia A
2012-12-01
Full Text Available Abstract Background The prevalence of maternal drug use during pregnancy in North America has been estimated to be as high as 6-10%. The consequences for the newborn include increased risk for perinatal mortality and ongoing physical, neurobehavioral, and psychosocial problems. Methadone is frequently used to wean women off street drugs but is implicated as a cause of adverse fetal/neonatal outcomes itself. The purpose of our study was to test the ability of maternal acupuncture treatment among mothers who use illicit drugs to reduce the frequency and severity of withdrawal symptoms among their newborns. Methods We randomly assigned chemically dependent pregnant women at BC Women’s Hospital in Vancouver, British Columbia to daily acupuncture treatments versus usual care. By necessity, neither our participants nor acupuncturists were blinded as to treatment allocation. Our primary outcome was days of neonatal morphine treatment for symptoms of neonatal withdrawal. Secondary neonatal outcomes included admission to a neonatal ICU and transfer to foster care. Results We randomized 50 women to acupuncture and 39 to standard care. When analyzed by randomized groups, we did not find benefit of acupuncture; the average length of treatment with morphine for newborns in the acupuncture group was 2.7 (6.3 compared to 2.8 (7.0 in the control group. Among newborns of women who were compliant with the acupuncture regime, we observed a reduction of 2.1 and 1.5 days in length of treatment for neonatal abstinence syndrome compared to the non-compliant and control groups, respectively. These differences were not statistically significant. Conclusions Acupuncture may be a safe and feasible treatment to assist mothers to reduce their dosage of methadone. Our results should encourage ongoing studies to test the ability of acupuncture to mitigate the severity of neonatal abstinence syndrome among their newborns. Clinical Trial Registration http
Time-dependent Relativistic Mean-field Theory and Random Phase Approximation
Institute of Scientific and Technical Information of China (English)
P.Ring; D.Vretenar; A.Wandelt; NguyenVanGiai; MAZhong-yu; CAOLi-gang
2001-01-01
The relativistic random phase approximation (RRPA) is derived from the time-dependent relativistic mean field (TD RMF) theory in the limit of small amplitude oscillations. In the no-sea approximation of the RMF theory, the RRPA configuration space includes not only the usual particle-hole ph-states, but also ah configurations, i.e. pairs formed from occupied states in the Fermi sea and empty negative-energy states in the Dirac sea. The contribution of the negative energy states to the RRPA matrices is examined in a schematic model, and the large effect of Dirac sea states on isoscalar strength distributions is illustrated for the giant monopole resonance in 116Sn. It is shown that
A modified NaSch model with density-dependent randomization for traffic flow
Zhu, H. B.; Ge, H. X.; Dong, L. Y.; Dai, S. Q.
2007-05-01
Based on the Nagel-Schreckenberg (NaSch) model of traffic flow, a modified cellular automaton (CA) traffic model with the density-dependent randomization (abbreviated as the DDR model) is proposed to simulate traffic flow. The fundamental diagram obtained by simulation shows the ability of this modified NaSch model to capture the essential features of traffic flow, e.g., synchronized flow, metastable state, hysteresis and phase separation at higher densities. Comparisons are made between this DDR model and the NaSch model, also between this DDR model and the VDR model. And the underlying mechanism is analyzed. All these results indicate that the presented model is reasonable and more realistic.
Hernández, Damián G.; Zanette, Damián H.; Samengo, Inés
2015-08-01
We develop the information-theoretical concepts required to study the statistical dependencies among three variables. Some of such dependencies are pure triple interactions, in the sense that they cannot be explained in terms of a combination of pairwise correlations. We derive bounds for triple dependencies, and characterize the shape of the joint probability distribution of three binary variables with high triple interaction. The analysis also allows us to quantify the amount of redundancy in the mutual information between pairs of variables, and to assess whether the information between two variables is or is not mediated by a third variable. These concepts are applied to the analysis of written texts. We find that the probability that a given word is found in a particular location within the text is not only modulated by the presence or absence of other nearby words, but also, on the presence or absence of nearby pairs of words. We identify the words enclosing the key semantic concepts of the text, the triplets of words with high pairwise and triple interactions, and the words that mediate the pairwise interactions between other words.
Hernández, Damián G; Samengo, Inés
2015-01-01
We develop the information-theoretical concepts required to study the statistical dependencies among three variables. Some of such dependencies are pure triple interactions, in the sense that they cannot be explained in terms of a combination of pairwise correlations. We derive bounds for triple dependencies, and characterize the shape of the joint probability distribution of three binary variables with high triple interaction. The analysis also allows us to quantify the amount of redundancy in the mutual information between pairs of variables, and to assess whether the information between two variables is or is not mediated by a third variable. These concepts are applied to the analysis of written texts. We find that the probability that a given word is found in a particular location within the text is not only modulated by the presence or absence of other nearby words, but also, on the presence or absence of nearby pairs of words. We identify the words enclosing the key semantic concepts of the text, the tr...
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Senol Emir
2016-04-01
Full Text Available The purpose of this study is to explore the importance and ranking of technical analysis variables in Turkish banking sector. Random Forest method is used for determining importance scores of inputs for eight banks in Borsa Istanbul. Then two predictive models utilizing Random Forest (RF and Artificial Neural Networks (ANN are built for predicting BIST-100 index and bank closing prices. Results of the models are compared by three metrics namely Mean Absolute Error (MAE, Mean Square Error (MSE, Median Absolute Error (MedAE. Findings show that moving average (MAV-100 is the most important variable for both BIST -100 index and bank closing prices. Therefore, investors should follow this technical indicator with respect to Turkish banks. In addition ANN shows better performance for all metrics.
Theodorou, C. G.; Ioannidis, E. G.; Haendler, S.; Josse, E.; Dimitriadis, C. A.; Ghibaudo, G.
2016-03-01
In this paper, a parametric statistical analysis of the low-frequency noise (LFN) in very small area (W·L ≈ 10-3 μm2) 14 nm fully depleted silicon-on-insulator (FD-SOI) n-MOS devices is presented. It has been demonstrated that the LFN origin is due to carrier trapping/detrapping into gate dielectric traps near the interface and the mean noise level in such small area MOSFETs is well approached by the carrier number fluctuations model in all measurement conditions. The impact of gate voltage bias and temperature on the LFN variability, as well as the standard deviation dependence on frequency have been studied for the first time, focusing on their relation to the Random Telegraph Noise (RTN) effect and its characteristics.
Major, Péter
1999-01-01
Let $\\xi_1,\\xi_2\\ldots$ be a sequence of i.i.d.random variables, and consider the elementary symmetric polynomial $S ^(k)(n)$ of order $k =k(n)$ of the first $n$ elements $\\xi_1\\ldots,\\xi_n$ of this sequence. We are interested in the limit behavior of $S^(k) (n)$ with an appropriate transformation if $k(n)/n\\rightarrow\\alpha, 0
Kim, Junhan; Chan, Chi-kwan; Medeiros, Lia; Ozel, Feryal; Psaltis, Dimitrios
2016-01-01
The Event Horizon Telescope (EHT) is a millimeter-wavelength, very-long baseline interferometer (VLBI) that is capable of observing black holes with horizon-scale resolution. Early observations have revealed variable horizon-scale emission in the Galactic Center black hole, Sagittarius A* (Sgr A*). Comparing such observations to time-dependent general relativistic magnetohydrodynamic (GRMHD) simulations requires statistical tools that explicitly consider the variability in both the data and the models. We develop here a Bayesian method to compare time-resolved simulation images to variable VLBI data, in order to infer model parameters and perform model comparisons. We use mock EHT data based on GRMHD simulations to explore the robustness of this Bayesian method and contrast it to approaches that do not consider the effects of variability. We find that time-independent models lead to offset values of the inferred parameters with artificially reduced uncertainties. We also apply our method to the early EHT data...
International Nuclear Information System (INIS)
Based on simple random sampling (SRS), we propose a Monte Carlo method for the faster computation of the smoothed part of the density of nuclear states. To test the applicability of the SRS approach we study in this framework the excitation energy (E), angular momentum (J) and parity dependence of nuclear level densities for an independent particle system. As an illustrative example, we consider a pf-shell nucleus, 48Cr. It is found that the values of a few lower order moments for the state density I(E) calculated using SRS and combinatorial (or direct counting) methods are almost the same and a locally smoothed part of the state density can be constructed using these moments in a univariate Edgeworth expansion. We calculate the energy dependent spin-cutoff factor and parity asymmetry and find that for both cases the SRS approach works quite well. We use the SRS moments to construct different forms of the bivariate distribution for I(E,M) (M is the z-component of J) namely (a) a bivariate Edgeworth expansion, (b) a product of the univariate Edgeworth expansion (I(E)) and a Gaussian form for conditional M distribution I(M vertical stroke E) and (c) a product of the univariate Edgeworth expansions for both I(E) and I(M vertical stroke E) and compare the resulting fixed-J level density Il(E,J) with the corresponding combinatorial results. (orig.)
Nagar, Lokesh; Dutta, Pankaj; Jain, Karuna
2014-05-01
In the present day business scenario, instant changes in market demand, different source of materials and manufacturing technologies force many companies to change their supply chain planning in order to tackle the real-world uncertainty. The purpose of this paper is to develop a multi-objective two-stage stochastic programming supply chain model that incorporates imprecise production rate and supplier capacity under scenario dependent fuzzy random demand associated with new product supply chains. The objectives are to maximise the supply chain profit, achieve desired service level and minimise financial risk. The proposed model allows simultaneous determination of optimum supply chain design, procurement and production quantities across the different plants, and trade-offs between inventory and transportation modes for both inbound and outbound logistics. Analogous to chance constraints, we have used the possibility measure to quantify the demand uncertainties and the model is solved using fuzzy linear programming approach. An illustration is presented to demonstrate the effectiveness of the proposed model. Sensitivity analysis is performed for maximisation of the supply chain profit with respect to different confidence level of service, risk and possibility measure. It is found that when one considers the service level and risk as robustness measure the variability in profit reduces.
Ahmadi-Abhari Seyed Ali; Radgoodarzi Reza; Assadi Seyed Mohammad
2003-01-01
Abstract Background Results of preclinical studies suggest that the GABAB receptor agonist baclofen may be useful in treatment of opioid dependence. This study was aimed at assessing the possible efficacy of baclofen for maintenance treatment of opioid dependence. Methods A total of 40 opioid-dependent patients were detoxified and randomly assigned to receive baclofen (60 mg/day) or placebo in a 12-week, double blind, parallel-group trial. Primary outcome measure was retention in treatment. S...
On clustering financial time series: a need for distances between dependent random variables
Marti, Gautier; Nielsen, Frank; Donnat, Philippe; Andler, Sébastien
2016-01-01
The following working document summarizes our work on the clustering of financial time series. It was written for a workshop on information geometry and its application for image and signal processing. This workshop brought several experts in pure and applied mathematics together with applied researchers from medical imaging, radar signal processing and finance. The authors belong to the latter group. This document was written as a long introduction to further development of geometric tools i...
FUNCTIONAL DIFFERENTIAL EQUATIONS WITH STATE-DEPENDENT DELAY AND RANDOM EFFECTS
Directory of Open Access Journals (Sweden)
AMEL BENAISSA
2015-07-01
Full Text Available In this work we study the existence of mild solutions of a functional differential equation with delay and random effects. We use a random fixed point theorem with stochastic domain to show the existence of mild random solutions.
Scales of variability of black carbon plumes and their dependence on resolution of ECHAM6-HAM
Weigum, Natalie; Stier, Philip; Schutgens, Nick; Kipling, Zak
2015-04-01
Prediction of the aerosol effect on climate depends on the ability of three-dimensional numerical models to accurately estimate aerosol properties. However, a limitation of traditional grid-based models is their inability to resolve variability on scales smaller than a grid box. Past research has shown that significant aerosol variability exists on scales smaller than these grid-boxes, which can lead to discrepancies between observations and aerosol models. The aim of this study is to understand how a global climate model's (GCM) inability to resolve sub-grid scale variability affects simulations of important aerosol features. This problem is addressed by comparing observed black carbon (BC) plume scales from the HIPPO aircraft campaign to those simulated by ECHAM-HAM GCM, and testing how model resolution affects these scales. This study additionally investigates how model resolution affects BC variability in remote and near-source regions. These issues are examined using three different approaches: comparison of observed and simulated along-flight-track plume scales, two-dimensional autocorrelation analysis, and 3-dimensional plume analysis. We find that the degree to which GCMs resolve variability can have a significant impact on the scales of BC plumes, and it is important for models to capture the scales of aerosol plume structures, which account for a large degree of aerosol variability. In this presentation, we will provide further results from the three analysis techniques along with a summary of the implication of these results on future aerosol model development.
Institute of Scientific and Technical Information of China (English)
无
2007-01-01
In this article, the dependent steps of a negative drift random walk are modelled as a two-sided linear process Xn =-μ+∞∑j=-∞ψn-jεj, where {ε, εn; -∞＜ n ＜ +∞}is a sequence of independent, identically distributed random variables with zero mean, μ＞0 is a constant and the coefficients {ψi;-∞＜ i ＜∞} satisfy 0 ＜∞∑j=-∞|jψj| ＜∞. Under the conditions that the distribution function of |ε| has dominated variation and ε satisfies certain tail balance conditions, the asymptotic behavior of P{supn≥0(-nμ+∞∑j=-∞εjβnj) ＞ x}is discussed. Then the result is applied to ultimate ruin probability.
Improved Estimators of Population Mean Using Two Auxiliary Variables in Stratified random Sampling
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Rajesh Singh
2012-01-01
Full Text Available An exponential family of estimators, which use the information of two auxiliary variables in the stratified sampling, is proposed to estimate the population mean of the variable under study. The mean-squared error of the suggested family of estimators are derived under large sample approximation. The family of estimators in its optimum case is carried out to show the properties of the proposed estimators.
LENUS (Irish Health Repository)
Cronin, C C
2012-02-03
Abnormalities of the renin-angiotensin system have been reported in patients with diabetes mellitus and with diabetic complications. In this study, plasma concentrations of prorenin, renin, and aldosterone were measured in a stratified random sample of 110 insulin-dependent (Type 1) diabetic patients attending our outpatient clinic. Fifty-four age- and sex-matched control subjects were also examined. Plasma prorenin concentration was higher in patients without complications than in control subjects when upright (geometric mean (95% confidence intervals (CI): 75.9 (55.0-105.6) vs 45.1 (31.6-64.3) mU I-1, p < 0.05). There was no difference in plasma prorenin concentration between patients without and with microalbuminuria and between patients without and with background retinopathy. Plasma renin concentration, both when supine and upright, was similar in control subjects, in patients without complications, and in patients with varying degrees of diabetic microangiopathy. Plasma aldosterone was suppressed in patients without complications in comparison to control subjects (74 (58-95) vs 167 (140-199) ng I-1, p < 0.001) and was also suppressed in patients with microvascular disease. Plasma potassium was significantly higher in patients than in control subjects (mean +\\/- standard deviation: 4.10 +\\/- 0.36 vs 3.89 +\\/- 0.26 mmol I-1; p < 0.001) and plasma sodium was significantly lower (138 +\\/- 4 vs 140 +\\/- 2 mmol I-1; p < 0.001). We conclude that plasma prorenin is not a useful early marker for diabetic microvascular disease. Despite apparently normal plasma renin concentrations, plasma aldosterone is suppressed in insulin-dependent diabetic patients.
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Savka I.Ya.
2010-12-01
Full Text Available In the Cartesian product of a time segment and a spatial multidimensional torus, we investigate nonlocal two-point problem with dependent coefficients on a smooth curve in conditions for typeless partial differential equation of the second order in time variable. Conditions for the one-valued solvability of the problem are established. Metric theorem on lower bound of small denominators on smooth curve are proved.
Continuous infusion of propofol at variable rates in a time dependent in cats
Felipe Comassetto; Martielo Ivan Gehrcke; Marcos Paulo Antunes de Lima; Ronise Tocheto; Nilson Oleskovicz
2015-01-01
Felines biotransforms propofol slowly developing cumulative effect. The aim this study was to develop a scheme of continuous infusion of propofol at time dependent variable rate in cats. Sixteen healthy female cats undergoing elective ovariohysterectomy and received as premedication dexmedetomidine (2.5 ?g/kg), methadone (0.5 mg/kg) and ketamine (0.5 mg/kg) administrated at intramuscular rote. After 15 minutes , the animals were allocated into two groups : Fixed Rate (GFR), which received pro...
Darling, Warren G.; Wolf, Steven L.; Butler, Andrew J.
2006-01-01
The purpose of this research was to determine whether motor cortex excitability assessed using transcranial magnetic stimulation (TMS) is less variable when subjects maintain a visually controlled low-level contraction of the muscle of interest. We also examined the dependence of single motor evoked potential (MEP) amplitude on stimulation intensity and pre-stimulus muscle activation level using linear and non-linear multiple regression analysis. Eight healthy adult subjects received single p...
Galea, J. M.; Ruge, D.; Buijink, A.; Bestmann, S.; Rothwell, J. C.
2013-01-01
Action selection describes the high-level process which selects between competing movements. In animals, behavioural variability is critical for the motor exploration required to select the action which optimizes reward and minimizes cost/punishment, and is guided by dopamine (DA). The aim of this study was to test in humans whether low-level movement parameters are affected by punishment and reward in ways similar to high-level action selection. Moreover, we addressed the proposed dependence...
The time-dependent relativistic mean-field theory and the random phase approximation
International Nuclear Information System (INIS)
The Relativistic Random Phase Approximation (RRPA) is derived from the Time-Dependent Relativistic Mean-Field (TD RMF) theory in the limit of small amplitude oscillations. In the no-sea approximation of the RMF theory, the RRPA configuration space includes not only the usual particle-hole ph-states, but also αh-configurations, i.e. pairs formed from occupied states in the Fermi sea and empty negative-energy states in the Dirac sea. The contribution of the negative-energy states to the RRPA matrices is examined in a schematic model, and the large effect of Dirac-sea states on isoscalar strength distributions is illustrated for the giant monopole resonance in 116Sn. It is shown that, because the matrix elements of the time-like component of the vector-meson fields which couple the αh-configurations with the ph-configurations are strongly reduced with respect to the corresponding matrix elements of the isoscalar scalar meson field, the inclusion of states with unperturbed energies more than 1.2 GeV below the Fermi energy has a pronounced effect on giant resonances with excitation energies in the MeV region. The influence of nuclear magnetism, i.e. the effect of the spatial components of the vector fields is examined, and the difference between the nonrelativistic and relativistic RPA predictions for the nuclear matter compression modulus is explained
Wave diffusion and mesoscopic dynamics, towards a universal time-dependent random scattering matrix
Weaver, Richard L.
2007-01-01
We concern ourselves with the prediction of mesoscopic wave phenomena from statistical knowledge of classical trajectories. A diffusing particle picture for the flow of mean probability in chaotic systems is used to estimate dynamical features of mean square time-domain S matrices for waves coupled in and out through one perfectly open channel. A random process with that mean square, and with the additional constraint of unitarity, is then shown to lead to plausible S matrices with familiar mesoscopic wave dynamics. Features that are generated by this procedure include enhanced backscatter, quantum echo, power law tails, level repulsion and spectral rigidity. It is remarkable that such rich behaviours arise from such simple constraints. We conjecture that a generalization to n × n S matrices would exhibit behaviour identical to that of a Hamiltonian taken from the Gaussian Orthogonal or Unitary Ensembles (GOE or GUE) depending on its symmetries. Further constraining the S matrices to reproduce non universal aspects of classical dynamics, (known short time behaviours, periodic orbits, stable islands...) may generate mesoscopic wave features of such systems.
International Nuclear Information System (INIS)
Several problems related to the application of the theory of random by means of state variables are studied. The well-known equations that define the propagation of the mean and the variance for linear and non-linear systems are first presented. The Monte Carlo method is next resorted to in order to determine the applicability of the hypothesis of a normally distributed output in case of linear systems subjected to non-Gaussian excitations. Finally, attention is focused on the properties of linear filters and modulation functions proposed to simulate seismic excitations as non stationary random processes. Acceleration spectra obtained by multiplying rms spectra by a constant factor are compared with design spectra suggested by several authors for various soil conditions. In every case, filter properties are given. (Author)
Zied, Hajej; Dellagi, Sofiene; Rezg, Nidhal
2011-01-01
Abstract This paper deals with combined production and maintenance plans for a manufacturing system satisfying a random demand. We first establish an optimal production plan which minimizes the average total inventory and production cost. Secondly, using this optimal production plan, and taking into account the deterioration of the machine according to its production rate, we derive an optimal maintenance schedule which minimizes the maintenance cost. A numerical example illustrate...
Plass-Johnson, Jeremiah G; Taylor, Marc H; Husain, Aidah A A; Teichberg, Mirta C; Ferse, Sebastian C A
2016-01-01
Changes in the coral reef complex can affect predator-prey relationships, resource availability and niche utilisation in the associated fish community, which may be reflected in decreased stability of the functional traits present in a community. This is because particular traits may be favoured by a changing environment, or by habitat degradation. Furthermore, other traits can be selected against because degradation can relax the association between fishes and benthic habitat. We characterised six important ecological traits for fish species occurring at seven sites across a disturbed coral reef archipelago in Indonesia, where reefs have been exposed to eutrophication and destructive fishing practices for decades. Functional diversity was assessed using two complementary indices (FRic and RaoQ) and correlated to important environmental factors (live coral cover and rugosity, representing local reef health, and distance from shore, representing a cross-shelf environmental gradient). Indices were examined for both a change in their mean, as well as temporal (short-term; hours) and spatial (cross-shelf) variability, to assess whether fish-habitat association became relaxed along with habitat degradation. Furthermore, variability in individual traits was examined to identify the traits that are most affected by habitat change. Increases in the general reef health indicators, live coral cover and rugosity (correlated with distance from the mainland), were associated with decreases in the variability of functional diversity and with community-level changes in the abundance of several traits (notably home range size, maximum length, microalgae, detritus and small invertebrate feeding and reproductive turnover). A decrease in coral cover increased variability of RaoQ while rugosity and distance both inversely affected variability of FRic; however, averages for these indices did not reveal patterns associated with the environment. These results suggest that increased
Plass-Johnson, Jeremiah G.; Taylor, Marc H.; Husain, Aidah A. A.; Teichberg, Mirta C.; Ferse, Sebastian C. A.
2016-01-01
Changes in the coral reef complex can affect predator-prey relationships, resource availability and niche utilisation in the associated fish community, which may be reflected in decreased stability of the functional traits present in a community. This is because particular traits may be favoured by a changing environment, or by habitat degradation. Furthermore, other traits can be selected against because degradation can relax the association between fishes and benthic habitat. We characterised six important ecological traits for fish species occurring at seven sites across a disturbed coral reef archipelago in Indonesia, where reefs have been exposed to eutrophication and destructive fishing practices for decades. Functional diversity was assessed using two complementary indices (FRic and RaoQ) and correlated to important environmental factors (live coral cover and rugosity, representing local reef health, and distance from shore, representing a cross-shelf environmental gradient). Indices were examined for both a change in their mean, as well as temporal (short-term; hours) and spatial (cross-shelf) variability, to assess whether fish-habitat association became relaxed along with habitat degradation. Furthermore, variability in individual traits was examined to identify the traits that are most affected by habitat change. Increases in the general reef health indicators, live coral cover and rugosity (correlated with distance from the mainland), were associated with decreases in the variability of functional diversity and with community-level changes in the abundance of several traits (notably home range size, maximum length, microalgae, detritus and small invertebrate feeding and reproductive turnover). A decrease in coral cover increased variability of RaoQ while rugosity and distance both inversely affected variability of FRic; however, averages for these indices did not reveal patterns associated with the environment. These results suggest that increased
Wang, Kezhi
2014-09-01
The sum of ratios of products of independent 2642 2642α-μ random variables (RVs) is approximated by using the Generalized Gamma ratio approximation (GGRA) with Gamma ratio approximation (GRA) as a special case. The proposed approximation is used to calculate the outage probability of the equal gain combining (EGC) or maximum ratio combining (MRC) receivers for wireless multihop relaying or multiple scattering systems considering interferences. Numerical results show that the newly derived approximation works very well verified by the simulation, while GRA has a slightly worse performance than GGRA when outage probability is below 0.1 but with a more simplified form.
Heart rate variability and skin conductance biofeedback: A triple-blind randomized controlled study
Raaijmakers, S.F.; Steel,F.W.; Goede, M. de; Wouwe, N.C. van; Erp, J.B.F. van; Brouwer, A.M.
2013-01-01
High heart rate variability (HRV) and low skin conductance level (SCL) have been associated with low levels of stress. Biofeedback - providing an individual with online information about his or her own physiological state – may help to change these signals in the desired direction and therewith impr
Demographic variability and density-dependent dynamics of a free-ranging rhesus macaque population
Hernández-Pacheco, Raisa; Rawlins, Richard G.; Kessler, Matthew J.; Williams, Lawrence E.; Ruiz-Maldonado, Tagrid M.; González-Martínez, Janis; Ruiz-Lambides, Angelina V.; Sabat, Alberto M.
2014-01-01
Density-dependence is hypothesized as the major mechanism of population regulation. However, the lack of long-term demographic data has hampered the use of density-dependent models in nonhuman primates. In this study, we make use of the long-term demographic data from Cayo Santiago’s rhesus macaques to parameterize and analyze both a density-independent and a density-dependent population matrix model, and compare their projections with the observed population changes. We also employ a retrospective analysis to determine how variance in vital rates, and covariance among them, contributed to the observed variation in long-term fitness across different levels of population density. The population exhibited negative density-dependence in fertility and the model incorporating this relationship accounted for 98% of the observed population dynamics. Variation in survival and fertility of sexually active individuals contributed the most to the variation in long-term fitness, while vital rates displaying high temporal variability exhibited lower sensitivities. Our findings are novel in describing density-dependent dynamics in a provisioned primate population, and in suggesting that selection is acting to lower the variance in the population growth rate by minimizing the variation in adult survival at high density. Because density-dependent mechanisms may become stronger in wild primate populations due to increasing habitat loss and food scarcity, our study demonstrates it is important to incorporate variation in population size, as well as demographic variability into population viability analyses for a better understanding of the mechanisms regulating the growth of primate populations. PMID:23847126
O’Hearn, Katharine; McNally, Dayre; Choong, Karen; Acharya, Anand; Wong, Hector R.; Lawson, Margaret; Ramsay, Tim; McIntyre, Lauralyn; Gilfoyle, Elaine; Tucci, Marisa; Wensley, David; Gottesman, Ronald; Morrison, Gavin; Menon, Kusum; ,
2016-01-01
Background Physicians often administer corticosteroids for the treatment of fluid and vasoactive infusion dependent pediatric shock. This use of corticosteroids is controversial, however, and has never been studied in a pediatric randomized controlled trial (RCT). This pilot trial will determine the feasibility of a larger RCT on the role of corticosteroids in pediatric shock. Methods/design Steroids in Fluid and/or Vasoactive Infusion Dependent Pediatric Shock (STRIPES) is a pragmatic, seven...
Distance and Azimuthal Dependence of Ground‐Motion Variability for Unilateral Strike‐Slip Ruptures
Vyas, Jagdish Chandra
2016-06-21
We investigate near‐field ground‐motion variability by computing the seismic wavefield for five kinematic unilateral‐rupture models of the 1992 Mw 7.3 Landers earthquake, eight simplified unilateral‐rupture models based on the Landers event, and a large Mw 7.8 ShakeOut scenario. We include the geometrical fault complexity and consider different 1D velocity–density profiles for the Landers simulations and a 3D heterogeneous Earth structure for the ShakeOut scenario. For the Landers earthquake, the computed waveforms are validated using strong‐motion recordings. We analyze the simulated ground‐motion data set in terms of distance and azimuth dependence of peak ground velocity (PGV). Our simulations reveal that intraevent ground‐motion variability Graphic is higher in close distances to the fault (<20 km) and decreases with increasing distance following a power law. This finding is in stark contrast to constant sigma‐values used in empirical ground‐motion prediction equations. The physical explanation of a large near‐field Graphic is the presence of strong directivity and rupture complexity. High values of Graphic occur in the rupture‐propagation direction, but small values occur in the direction perpendicular to it. We observe that the power‐law decay of Graphic is primarily controlled by slip heterogeneity. In addition, Graphic, as function of azimuth, is sensitive to variations in both rupture speed and slip heterogeneity. The azimuth dependence of the ground‐motion mean μln(PGV) is well described by a Cauchy–Lorentz function that provides a novel empirical quantification to model the spatial dependency of ground motion. Online Material: Figures of slip distributions, residuals to ground‐motion prediction equations (GMPEs), distance and azimuthal dependence, and directivity predictor of ground‐motion variability for different source models.
McKay, James R.; Van Horn, Deborah H. A.; Oslin, David W.; Lynch, Kevin G.; Ivey, Megan; Ward, Kathleen; Drapkin, Michelle L.; Becher, Julie R.; Coviello, Donna M.
2010-01-01
Objective: The study tested whether adding up to 18 months of telephone continuing care, either as monitoring and feedback (TM) or longer contacts that included counseling (TMC), to intensive outpatient programs (IOPs) improved outcomes for alcohol-dependent patients. Method: Participants (N = 252) who completed 3 weeks of IOP were randomized to…
Williamson, Brenda D.; Campbell-Whatley, Gloria D.; Lo, Ya-yu
2009-01-01
Group contingencies have the advantages of encouraging individual students to collectively feel responsible for appropriate and inappropriate classroom behaviors and have shown effectiveness in improving students' behavior. The purpose of this study was to investigate the effects of a random dependent group contingency on the on-task behaviors of…
Variability of visual responses of superior colliculus neurons depends on stimulus velocity.
Mochol, Gabriela; Wójcik, Daniel K; Wypych, Marek; Wróbel, Andrzej; Waleszczyk, Wioletta J
2010-03-01
Visually responding neurons in the superficial, retinorecipient layers of the cat superior colliculus receive input from two primarily parallel information processing channels, Y and W, which is reflected in their velocity response profiles. We quantified the time-dependent variability of responses of these neurons to stimuli moving with different velocities by Fano factor (FF) calculated in discrete time windows. The FF for cells responding to low-velocity stimuli, thus receiving W inputs, increased with the increase in the firing rate. In contrast, the dynamics of activity of the cells responding to fast moving stimuli, processed by Y pathway, correlated negatively with FF whether the response was excitatory or suppressive. These observations were tested against several types of surrogate data. Whereas Poisson description failed to reproduce the variability of all collicular responses, the inclusion of secondary structure to the generating point process recovered most of the observed features of responses to fast moving stimuli. Neither model could reproduce the variability of low-velocity responses, which suggests that, in this case, more complex time dependencies need to be taken into account. Our results indicate that Y and W channels may differ in reliability of responses to visual stimulation. Apart from previously reported morphological and physiological differences of the cells belonging to Y and W channels, this is a new feature distinguishing these two pathways. PMID:20203179
对随机变量独立性的几点认识%Some Recognition on Independence of Random Variables
Institute of Scientific and Technical Information of China (English)
闻斌
2012-01-01
独立性是概率统计的一个重要概念，给出了随机变量独立性的一些特殊性质．%Independence is an important concept in probability and statistics. In this paper, we present a number of propositions on independence of random variables; furthermore some properties of the independence of random variables are given.
Ohlberger, Jan; Rogers, Lauren A; Stenseth, Nils Chr
2014-01-01
A persistent debate in population ecology concerns the relative importance of environmental stochasticity and density dependence in determining variability in adult year-class strength, which contributes to future reproduction as well as potential yield in exploited populations. Apart from the strength of the processes, the timing of density regulation may affect how stochastic variation, for instance through climate, translates into changes in adult abundance. In this study, we develop a life-cycle model for the population dynamics of a large marine fish population, Northeast Arctic cod, to disentangle the effects of density-independent and density-dependent processes on early life-stages, and to quantify the strength of compensatory density dependence in the population. The model incorporates information from scientific surveys and commercial harvest, and dynamically links multiple effects of intrinsic and extrinsic factors on all life-stages, from eggs to spawners. Using a state-space approach we account for observation error and stochasticity in the population dynamics. Our findings highlight the importance of density-dependent survival in juveniles, indicating that this period of the life cycle largely determines the compensatory capacity of the population. Density regulation at the juvenile life-stage dampens the impact of stochastic processes operating earlier in life such as environmental impacts on the production of eggs and climate-dependent survival of larvae. The timing of stochastic versus regulatory processes thus plays a crucial role in determining variability in adult abundance. Quantifying the contribution of environmental stochasticity and compensatory mechanisms in determining population abundance is essential for assessing population responses to climate change and exploitation by humans. PMID:24893001
Directory of Open Access Journals (Sweden)
Patrícia M Pinto
2004-03-01
Full Text Available The patterns of genetic variation of samples of Candida spp. isolated from patients infected with human immunodeficiency virus in Vitória, state of Espírito Santo, Brazil, were examined. Thirty-seven strains were isolated from different anatomical sites obtained from different infection episodes of 11 patients infected with the human immunodeficiency virus (HIV. These samples were subjected to randomly amplified polymorphic DNA (RAPD analysis using 9 different primers. Reproducible and complex DNA banding patterns were obtained. The experiments indicated evidence of dynamic process of yeast colonization in HIV-infected patients, and also that certain primers are efficient in the identification of species of the Candida genus. Thus, we conclude that RAPD analysis may be useful in providing genotypic characters for Candida species typing in epidemiological investigations, and also for the rapid identification of pathogenic fungi.
Random variables in forest policy: A systematic sensitivity analysis using CGE models
International Nuclear Information System (INIS)
Computable general equilibrium (CGE) models are extensively used to simulate economic impacts of forest policies. Parameter values used in these models often play a central role in their outcome. Since econometric studies and best guesses are the main sources of these parameters, some randomness exists about the 'true' values of these parameters. Failure to incorporate this randomness into these models may limit the degree of confidence in the validity of the results. In this study, we conduct a systematic sensitivity analysis (SSA) to assess the economic impacts of: 1) a 1 % increase in tax on Canadian lumber and wood products exports to the United States (US), and 2) a 1% decrease in technical change in the lumber and wood products and pulp and paper sectors of the US and Canada. We achieve this task by using an aggregated version of global trade model developed by Hertel (1997) and the automated SSA procedure developed by Arndt and Pearson (1996). The estimated means and standard deviations suggest that certain impacts are more likely than others. For example, an increase in export tax is likely to cause a decrease in Canadian income, while an increase in US income is unlikely. On the other hand, a decrease in US welfare is likely, while an increase in Canadian welfare is unlikely, in response to an increase in tax. It is likely that income and welfare both fall in Canada and the US in response to a decrease in the technical change in lumber and wood products and pulp and paper sectors 21 refs, 1 fig, 5 tabs
Chen, Bo; Krajewski, Witold F.
2015-04-01
Recession analysis across scales can provide insight into the spatial aggregation of hydrologic processes. Accordingly, we analyzed individual late-time recession curves from 25 nested USGS stream gauges over a period of ∼150 days with negligible precipitation during the 2012-2013 North American drought. These gauges are located in the Iowa and Cedar River basins and drain areas ranging from ∼70 to 17,000 km2. Our data analyses show that these late-time recession processes can be represented by a linear reservoir model with a constant recession time scale of about 34 days, indicating linear and homogeneous recession behaviors at the large scales investigated. However, others have shown that the early-time recession process becomes more nonlinear as spatial scale and, thus, spatial variability increases. We developed a distributed drainage model as a diagnostic tool to understand these seemingly contradictory recession characteristics at multiple spatial scales and different stages. With a hierarchical description of the recession variability at the hillslope scale, our model can simultaneously produce the increasing nonlinear early-time and the linear and homogenous late-time recession behaviors at larger scales. The hierarchical representation classifies hillslopes according to the Strahler orders of the stream links into which they drain. We postulate that a larger difference in recession behaviors will occur between hillslopes from different orders than between those from the same order. Overall, this study shows how the spatial randomness and nonrandomness of small-scale process variability control the hydrologic responses at larger scales and suggests a combined (nonrandom-random) representation of watersheds for aggregating hydrologic processes.
Memory effects, two color percolation, and the temperature dependence of Mott variable-range hopping
Agam, Oded; Aleiner, Igor L.
2014-06-01
There are three basic processes that determine hopping transport: (a) hopping between normally empty sites (i.e., having exponentially small occupation numbers at equilibrium), (b) hopping between normally occupied sites, and (c) transitions between normally occupied and unoccupied sites. In conventional theories all these processes are considered Markovian and the correlations of occupation numbers of different sites are believed to be small (i.e., not exponential in temperature). We show that, contrary to this belief, memory effects suppress the processes of type (c) and manifest themselves in a subleading exponential temperature dependence of the variable-range hopping conductivity. This temperature dependence originates from the property that sites of type (a) and (b) form two independent resistor networks that are weakly coupled to each other by processes of type (c). This leads to a two-color percolation problem which we solve in the critical region.
Lloyd, Mark C; Cunningham, Jessica J; Bui, Marilyn M; Gillies, Robert J; Brown, Joel S; Gatenby, Robert A
2016-06-01
Spatial heterogeneity in tumors is generally thought to result from branching clonal evolution driven by random mutations that accumulate during tumor development. However, this concept rests on the implicit assumption that cancer cells never evolve to a fitness maximum because they can always acquire mutations that increase proliferative capacity. In this study, we investigated the validity of this assumption. Using evolutionary game theory, we demonstrate that local cancer cell populations will rapidly converge to the fittest phenotype given a stable environment. In such settings, cellular spatial heterogeneity in a tumor will be largely governed by regional variations in environmental conditions, for example, alterations in blood flow. Model simulations specifically predict a common spatial pattern in which cancer cells at the tumor-host interface exhibit invasion-promoting, rapidly proliferating phenotypic properties, whereas cells in the tumor core maximize their population density by promoting supportive tissue infrastructures, for example, to promote angiogenesis. We tested model predictions through detailed quantitative image analysis of phenotypic spatial distribution in histologic sections of 10 patients with stage 2 invasive breast cancers. CAIX, GLUT1, and Ki67 were upregulated in the tumor edge, consistent with an acid-producing invasive, proliferative phenotype. Cells in the tumor core were 20% denser than the edge, exhibiting upregulation of CAXII, HIF-1Î±, and cleaved caspase-3, consistent with a more static and less proliferative phenotype. Similarly, vascularity was consistently lower in the tumor center compared with the tumor edges. Lymphocytic immune responses to tumor antigens also trended to higher level in the tumor edge, although this effect did not reach statistical significance. Like invasive species in nature, cancer cells at the leading edge of the tumor possess a different phenotype from cells in the tumor core. Our results suggest
Vu, Van Hoan; Isableu, Brice; Berret, Bastien
2016-07-22
The purpose of this study was to investigate the nature of the variables and rules underlying the planning of unrestrained 3D arm reaching. To identify whether the brain uses kinematic, dynamic and energetic values in an isolated manner or combines them in a flexible way, we examined the effects of speed variations upon the chosen arm trajectories during free arm movements. Within the optimal control framework, we uncovered which (possibly composite) optimality criterion underlays at best the empirical data. Fifteen participants were asked to perform free-endpoint reaching movements from a specific arm configuration at slow, normal and fast speeds. Experimental results revealed that prominent features of observed motor behaviors were significantly speed-dependent, such as the chosen reach endpoint and the final arm posture. Nevertheless, participants exhibited different arm trajectories and various degrees of speed dependence of their reaching behavior. These inter-individual differences were addressed using a numerical inverse optimal control methodology. Simulation results revealed that a weighted combination of kinematic, energetic and dynamic cost functions was required to account for all the critical features of the participants' behavior. Furthermore, no evidence for the existence of a speed-dependent tuning of these weights was found, thereby suggesting subject-specific but speed-invariant weightings of kinematic, energetic and dynamic variables during the motor planning process of free arm movements. This suggested that the inter-individual difference of arm trajectories and speed dependence was not only due to anthropometric singularities but also to critical differences in the composition of the subjective cost function. PMID:27132233
Czech Academy of Sciences Publication Activity Database
Axelsson, Owe; Xin, H.; Neytcheva, M.
2015-01-01
Roč. 20, č. 2 (2015), s. 232-260. ISSN 1392-6292 Institutional support: RVO:68145535 Keywords : variable density * phase-field model * Navier-Stokes equations * preconditioning * variable viscosity Subject RIV: BA - General Mathematics Impact factor: 0.830, year: 2014 http://www.tandfonline.com/doi/abs/10.3846/13926292.2015.1021395
Burmeister Getz, E; Carroll, K J; Jones, B; Benet, L Z
2016-09-01
Current pharmacokinetic (PK) bioequivalence guidelines do not account for batch-to-batch variability in study design or analysis. Here we evaluate the magnitude of batch-to-batch PK variability for Advair Diskus 100/50. Single doses of fluticasone propionate and salmeterol combinations were administered by oral inhalation to healthy subjects in a randomized clinical crossover study comparing three different batches purchased from the market, with one batch replicated across two treatment periods. All pairwise comparisons between different batches failed the PK bioequivalence statistical test, demonstrating substantial PK differences between batches that were large enough to demonstrate bio-inequivalence in some cases. In contrast, between-replicate PK bioequivalence was demonstrated for the replicated batch. Between-batch variance was ∼40-70% of the estimated residual error. This large additional source of variability necessitates re-evaluation of bioequivalence assessment criteria to yield a result that is both generalizable and consistent with the principles of type I and type II error rate control. PMID:27037630
Park, Hame; Lueckmann, Jan-Matthis; von Kriegstein, Katharina; Bitzer, Sebastian; Kiebel, Stefan J
2016-01-01
Decisions in everyday life are prone to error. Standard models typically assume that errors during perceptual decisions are due to noise. However, it is unclear how noise in the sensory input affects the decision. Here we show that there are experimental tasks for which one can analyse the exact spatio-temporal details of a dynamic sensory noise and better understand variability in human perceptual decisions. Using a new experimental visual tracking task and a novel Bayesian decision making model, we found that the spatio-temporal noise fluctuations in the input of single trials explain a significant part of the observed responses. Our results show that modelling the precise internal representations of human participants helps predict when perceptual decisions go wrong. Furthermore, by modelling precisely the stimuli at the single-trial level, we were able to identify the underlying mechanism of perceptual decision making in more detail than standard models. PMID:26752272
The dependence of damage on internal variables and its incorporation into constitutive equations
International Nuclear Information System (INIS)
A model is presented for the prediction of the lifetime of metals in the high-temperature range under arbitrary variable uniaxial load. The influence of deformation on damage is discussed. The definition of damage in continuum damage mechanics, which allows indirect measurement of damage via the deformation behaviour, is adopted. To collect some knowledge about the damage evolution, damage is in two ways measured during the strain controlled LCF tests: change of the modulus of elasticity and decrease of the peak stress. Surprisingly, both methods lead to results which are in good agreement. The damage law is then developed by reference to known models and lifetime rules. The damage model is a modification of the creep damage law by Rabotnov. It is extended by a dependence on the inelastic strain rate used instead of the dependence on internal variables describing the internal state. The parameters of the damage model are determined with a view to apply them to AISI 316 L(N) austenitic steel. Some of the parameters are derived from standard creep experiments. To determine further parameters, the damage model is applied to the LCF tests. Both, failure behaviour and damage evolution are described well. (author)
Jauregui, Max; Tsallis, Constantino
2015-02-01
We consider correlated random variables X1, …, Xn taking values in {0, 1} such that, for any permutation π of {1, …, n}, the random vectors (X1, …, Xn) and (Xπ(1), …, Xπ(n)) have the same distribution. This distribution, which was introduced by Rodríguez et al. [J. Stat. Mech. 2008, P09006] and then generalized by Hanel et al. [Eur. Phys. J. B 72, 263 (2009)], is scale-invariant and depends on a real parameter ν > 0 (ν → ∞ implies independence). Putting Sn = X1 + ⋯ + Xn, the distribution of Sn - n/2 approaches a Q-Gaussian distribution with compact support (Q = 1 - 1/(ν - 1) 0, we show that ℙ(Sn = 0) decays to zero like a power law of the form 1/nν with a subdominant term of the form 1/nν+1. If 0 0 is an integer, we show that we can analytically find upper and lower bounds for the difference between ℙ(Sn/n ≤ x) and its (n → ∞) limit. We also show that these bounds vanish like a power law of the form 1/n with a subdominant term of the form 1/n2.
Recovery of microstructure properties: random variability of soil solid thermal conductivity
Directory of Open Access Journals (Sweden)
Stefaniuk Damian
2016-03-01
Full Text Available In this work, the complex microstructure of the soil solid, at the microscale, is modeled by prescribing the spatial variability of thermal conductivity coefficient to distinct soil separates. We postulate that the variation of thermal conductivity coefficient of each soil separate can be characterized by some probability density functions: fCl(λ, fSi(λ, fSa(λ, for clay, silt and sand separates, respectively. The main goal of the work is to recover/identify these functions with the use of back analysis based on both computational micromechanics and simulated annealing approaches. In other words, the following inverse problem is solved: given the measured overall thermal conductivities of composite soil find the probability density function f(λ for each soil separate. For that purpose, measured thermal conductivities of 32 soils (of various fabric compositions at saturation are used. Recovered functions f(λ are then applied to the computational micromechanics approach; predicted conductivities are in a good agreement with laboratory results.
Nam, Sungsik
2010-11-01
Order statistics find applications in various areas of communications and signal processing. In this paper, we introduce an unified analytical framework to determine the joint statistics of partial sums of ordered random variables (RVs). With the proposed approach, we can systematically derive the joint statistics of any partial sums of ordered statistics, in terms of the moment generating function (MGF) and the probability density function (PDF). Our MGF-based approach applies not only when all the K ordered RVs are involved but also when only the Ks(Ks < K) best RVs are considered. In addition, we present the closed-form expressions for the exponential RV special case. These results apply to the performance analysis of various wireless communication systems over fading channels. © 2006 IEEE.
Difference prophet inequalities for [0,1] -valued i.i.d. random variables with cost for observations
Kosters, Holger
2004-01-01
Let X1,X2,… be a sequence of [0,1]-valued i.i.d. random variables, let c≥0 be a sampling cost for each observation and let Yi=Xi−ic, i=1,2,…. For n=1,2,…, let M(Y1,…,Yn)=E(max 1≤i≤nYi) and V(Y1,…,Yn)=sup τ∈CnE(Yτ), where Cn denotes the set of all stopping rules for Y1,…,Yn. Sharp upper bounds for the difference M(Y1,…,Yn)−V(Y1,…,Yn) are given under various restrictions on c and n.
Institute of Scientific and Technical Information of China (English)
ZHENGZUKANG
1996-01-01
Suppose that Z1,Z2…,Zn are independent normal random variables with common mean μ and variance σ2. Then S2=∑n n=1 (zi-z)2/σ2 and T =（n-1的平方根）-Z/（S2/n的平方根） have x2n-1 distribution and tn-1 distribution respectively. If the normal assumption fails, there will be the remainders of the distribution functions and density functions. This paper gives the direct expansions of distribution functions and density functions of S2 and T up to o(n-1). They are more intuitive and convenient than usual Edgeworth expansions.
Chaotic Size Dependence in the Ising Model with Random Boundary Conditions
Enter, A.C.D. van; Medved’, I.; Netočný, K.
2002-01-01
We study the nearest-neighbour Ising model with a class of random boundary conditions, chosen from a symmetric i.i.d. distribution. We show for dimensions 4 and higher that almost surely the only limit points for a sequence of increasing cubes are the plus and the minus state. For d=2 and d=3 we pro
Angeletti, Florian; Abry, Patrice
2011-01-01
This contribution aims at studying the behaviour of the classical sample moment estimator, $S(n,q)= \\sum_{k=1}^n X_k^{q}/n $, as a function of the number of available samples $n$, in the case where the random variables $X$ are positive, have finite moments at all orders and are naturally of the form $X= \\exp Y$ with the tail of $Y$ behaving like $e^{-y^\\rho}$. This class of laws encompasses and generalizes the classical example of the log-normal law. This form is motivated by a number of applications stemming from modern statistical physics or multifractal analysis. Borrowing heuristic and analytical results from the analysis of the Random Energy Model in statistical physics, a critical moment $q_c(n)$ is defined as the largest statistical order $q$ up to which the sample mean estimator $S(n,q)$ correctly accounts for the ensemble average $\\E X^q$, for a given $n$. A practical estimator for the critical moment $q_c(n)$ is then proposed. Its statistical performance are studied analytically and illustrated nume...
Liu, Hongxue; Lu, Jiwei; Wolf, Stuart; Hodgson, Jim; Rutgers, Maarten
2013-01-01
We demonstrate a versatile variable field module (VFM) with capability of both field and angular dependent measurements up to 1800 Oe for scanning probe system. The magnetic field strength is changed by adjusting the distance between a rare earth magnet and the probe tip and is monitored in-situ by a built-in Hall sensor. Rotating the magnet allows the field vector to change from the horizontal to vertical direction and makes it possible to do angular dependent measurements. The capability of the VFM system is demonstrated by degaussing a floppy disk media with increasing magnetic field. Angular dependent measurements clearly show the evolution of magnetic domain structures, with a completely reversible magnetic force microscopy phase contrast observed when the magnetic field is rotated by 180{\\deg}. A further demonstration of out-of-plane and in-plane magnetic switching of CoFe2O4 pillars in CoFe2O4-BiFeO3 nanocomposites was presented and discussed.
Institute of Scientific and Technical Information of China (English)
Elena Ricart; Maria Esteve; Montserrat Andreu; Francesc Casellas; David Monfort; Miquel Sans; Natalia Oudovenko; Raúl Lafuente; Julián Panés
2007-01-01
AIM: To evaluate the efficacy of 5 compared to 10 granulocyteaphaeresis sessions in patients with active steroid-dependent ulcerative colitis.METHODS: In this pilot, prospective, multicenter randomized trial, 20 patients with moderately active steroid-dependent ulcerative colitis were randomized to 5 or 10 granulocyteaphaeresis sessions. The primary objective was clinical remission at wk 17. Secondary measures included endoscopic remission and steroid consumption.RESULTS: Nine patients were randomized to 5 granulocyteaphaeresis sessions (group 1) and L1 patients to 10 granulocyteaphaeresis sessions (group 2). At wk 17, 37.5% of patients in group 1 and 45.45% of patients in group 2 were in clinical remission. Clinical remission was accompanied by endoscopic remission in all cases.Eighty-six percent of patients achieving remission were steroid-free at wk 17. Daily steroid requirements were significantly lower in group 2. Eighty-nine per cent of patients remained in remission during a one year follow-up. One serious adverse event, not related to the study therapy, was reported.CONCLUSION: Granulocyteaphaeresis is safe and effective for the treatment of steroid-dependent ulcerative colitis. In this population, increasing the number of aphaeresis sessions is not associated with higher remission rates, but affords a significant steroid-sparing effect.
Directory of Open Access Journals (Sweden)
R. Wagner
2011-09-01
Full Text Available We present computational results on the shape dependency of the extinction and absorption cross sections of dustlike aerosol particles that were modeled as randomly oriented spheroids. Shape dependent variations in the extinction cross sections are largest in the size regime that is governed by the interference structure. Elongated spheroids best fitted measured extinction spectra of re-dispersed Saharan dust samples. For dust particles smaller than 1.5 μm in diameter and low absorption potential, shape effects on the absorption cross sections are very small.
International Nuclear Information System (INIS)
Based on algebraic dynamics and the concept of the concurrence of the entanglement, we investigate the evolutive properties of the two-qubit entanglement that formed by Heisenberg XXX models under a time-depending external held. For this system, the property of the concurrence that is only dependent on the coupling constant J and total values of the external field is proved. Furthermore, we found that the thermal concurrence of the system under a static random external field is a function of the coupling constant J, temperature T, and the magnitude of external held. (general)
Sharma, A K; Mendki, M J; Tikar, S N; Chandel, K; Sukumaran, D; Parashar, B D; Veer, Vijay; Agarwal, O P; Prakash, Shri
2009-10-01
Genetic variability and environmental factors may influence the refractiveness, propagation of pathogen and transmission of disease. Random amplified polymorphic DNA (RAPD) is one of the widely used molecular markers for population genetic diversity studies. In present study, RAPD is used to ascertain the genetic variability in Culex quinquefasciatus populations collected from various Indian geographical locations. Out of 50 RAPD primers screened, 14 primers exhibited clear, concrete and distinct banding pattern showing up to 100% polymorphism. Primer OPBD3 was tested with DNA of 14 geographical populations from India (including one laboratory population) showed 21 loci representing 14 populations with 100% polymorphism. The genetic diversity among the populations indicated the Shannon index (I) and gene diversity index (H(ST)), 0.48 and 0.31, respectively among the population, displaying rich genetic variation among the Cx. quinquefasciatus populations. Consensus tree showed two clusters indicating the genetic variation among the various geographical populations. The findings of this study may be useful to understand the population variation under different ecological conditions and development of effective vector management strategies. PMID:19577531
International Nuclear Information System (INIS)
Recent theoretical work predicts intrinsic toroidal rotation in the tokamak edge to depend strongly on the normalized major radial position of the X-point. With this motivation, we conducted a series of Ohmic L-mode shots on the Tokamak à Configuration Variable, moving the X-point from the inboard to the outboard edge of the last closed flux surface in both lower and upper single null configurations. The edge toroidal rotation evolved from strongly co-current for an inboard X-point to either vanishing or counter-current for an outboard X-point, in agreement with the theoretical expectations. The whole rotation profile shifted roughly rigidly with the edge rotation, resulting in variation of the peak core rotation by more than a factor of two. Core rotation reversals had little effect on the edge rotation. Edge rotation was slightly more counter-current for unfavorable than favorable ∇B drift discharges
Energy Technology Data Exchange (ETDEWEB)
Stoltzfus-Dueck, T., E-mail: tstoltzf@princeton.edu [Princeton University, Princeton, New Jersey 08544 (United States); Karpushov, A. N.; Sauter, O.; Duval, B. P.; Labit, B.; Reimerdes, H.; Vijvers, W. A. J. [École Polytechnique Fédérale de Lausanne (EPFL), Centre de Recherches en Physique des Plasmas (CRPP), CH-1015 Lausanne (Switzerland); Camenen, Y. [Aix-Marseille Université, CNRS, PIIM UMR 7345, 13397 Marseille (France)
2015-05-15
Recent theoretical work predicts intrinsic toroidal rotation in the tokamak edge to depend strongly on the normalized major radial position of the X-point. With this motivation, we conducted a series of Ohmic L-mode shots on the Tokamak à Configuration Variable, moving the X-point from the inboard to the outboard edge of the last closed flux surface in both lower and upper single null configurations. The edge toroidal rotation evolved from strongly co-current for an inboard X-point to either vanishing or counter-current for an outboard X-point, in agreement with the theoretical expectations. The whole rotation profile shifted roughly rigidly with the edge rotation, resulting in variation of the peak core rotation by more than a factor of two. Core rotation reversals had little effect on the edge rotation. Edge rotation was slightly more counter-current for unfavorable than favorable ∇B drift discharges.
Lv, Geli; Huang, Dazu; Guo, Ying
2016-05-01
The intensities of signal and local oscillator (LO) can be elegantly manipulated for the noise-based quantum system while manipulating the wavelength-dependent modulation in source to increase the performance of the continuous-variable key distribution in terms of the secret key rate and maximal transmission distance. The source-based additional noises can be tuned and stabilized to the suitable values to eliminate the effect of the LO fluctuations and defeat the potential attacks in imperfect quantum channels. It is firmly proved that the secret key rate can be manipulated in source over imperfect channels by the intensities of signal and LO with different wavelengths, which have an effect on the optimal signal-to-noise ratio of the heterodyne detectors resulting from the detection efficiency and the additional electronic noise as well. Simulation results show that there is a nice balance between the secret key rate and the maximum transmission distance.
Complexity of two-variable Dependence Logic and IF-Logic
Kontinen, Juha; Lohmann, Peter; Virtema, Jonni
2011-01-01
We study the two-variable fragments D^2 and IF^2 of dependence logic and independence-friendly logic. We consider the satisfiability and finite satisfiability problems of these logics and show that for D^2, both problems are NEXPTIME-complete, whereas for IF^2, the problems are undecidable. We also show that D^2 is strictly less expressive than IF^2 and that already in D^2, equicardinality of two unary predicates and infinity can be expressed (the latter in the presence of a constant symbol). This is an extended version of a publication in the proceedings of the 26th Annual IEEE Symposium on Logic in Computer Science (LICS 2011).
Directory of Open Access Journals (Sweden)
Jorge, N.
1996-04-01
Full Text Available Experiments were carried out in the absence of food to define the influence of significant variables of the frying process, i.e. oil unsaturation, temperature, surface-to-oil volume ratio, type of heating and dimethylpolysiloxane (DMPS addition. Special emphasis was placed on clarifying the action of the addition of low concentrations of DMPS to frying oils. From statistical evaluation based on the content of polar compounds, the strong influence of the variables surface-to-oil volume ratio, DMPS addition and oil unsaturation was deduced. However, changes due to 10ºC difference in temperature were not significant. Analysis of two-way interactions demonstrated that interactions between type of heating/DMPS addition, type of heating/oil unsaturation, surface-to-oil volume ratio/DMPS addition and surface-to-oiI volume ratio/oil unsaturation were significant, thus indicating the complexity of the frying process. Finally, it was found that increase in specific groups of compounds formed through oxidative polymerization as well as loss of natural antioxidants depended mainly on the total content of polar compounds and, at a second level, on the oil unsaturation.
A Randomized Trial of Contingency Management for Adolescent Marijuana Abuse and Dependence
Stanger, Catherine; Budney, Alan J.; Kamon, Jody L.; Thostensen, Jeff
2009-01-01
An initial efficacy test of an innovative behavioral outpatient treatment model for adolescents with problematic use of marijuana enrolled 69 adolescents, aged 14–18, and randomly assigned them to one of two treatment conditions. Both conditions received individualized Motivational Enhancement and Cognitive Behavioral Therapy (MET/CBT) and a twice-weekly drug-testing program. The experimental contingency management condition involved a clinic delivered, abstinence-based incentive program, and...
On The Dependence Structure of Wavelet Coefficients for Spherical Random Fields
Lan, Xiaohong; Marinucci, Domenico
2008-01-01
We consider the correlation structure of the random coefficients for a wide class of wavelet systems on the sphere (Mexican needlets) which were recently introduced in the literature by Geller and Mayeli (2007). We provide necessary and sufficient conditions for these coefficients to be asymptotic uncorrelated in the real and in the frequency domain. Here, the asymptotic theory is developed in the high resolution sense. Statistical applications are also discussed, in particular with reference...
Central limit theorems for the excursion sets volumes of weakly dependent random fields
Bulinski, Alexander; Timmermann, Florian
2010-01-01
The multivariate central limit theorems (CLT) for the volumes of excursion sets of stationary quasi-associated random fields on $\\mathbb{R}^d$ are proved. Special attention is paid to Gaussian and shot noise fields. Formulae for the covariance matrix of the limiting distribution are provided. Statistical versions of the CLT are considered as well. They employ three different estimators of the asymptotic covariance matrix. Some numerical results are also discussed.
Degree-degree dependencies in random graphs with heavy-tailed degrees
Hofstad, van der Remco; Litvak, Nelly
2014-01-01
Mixing patterns in large self-organizing networks, such as the Internet, the World Wide Web, social, and biological networks are often characterized by degree-degree dependencies between neighboring nodes. In assortative networks, the degree-degree dependencies are positive (nodes with similar degre
Precise Asymptotics for Random Matrices and Random Growth Models
Institute of Scientific and Technical Information of China (English)
Zhong Gen SU
2008-01-01
The author considers the largest eigenvalues of random matrices from Gaussian unitary ensemble and Laguerre unitary ensemble, and the rightmost charge in certain random growth models.We obtain some precise asymptotics results, which are in a sense similar to the precise asymptotics for sums of independent random variables in the context of the law of large numbers and complete convergence. Our proofs depend heavily upon the upper and lower tail estimates for random matrices and random growth models. The Tracy-Widom distribution plays a central role as well.
Radial dependence of line profile variability in seven O9--B0.5 stars
Martins, F.; Marcolino, W.; D. J. Hillier; Donati, J.-F.; Bouret, J. -C.
2014-01-01
Massive stars show a variety of spectral variability: presence of discrete absorption components in UV P-Cygni profiles, optical line profile variability, X-ray variability, radial velocity modulations. Our goal is to study the spectral variability of single OB stars to better understand the relation between photospheric and wind variability. For that, we rely on high spectral resolution, high signal-to-noise ratio optical spectra collected with the spectrograph NARVAL on the Telescope Bernar...
Guigues, Vincent
2014-01-01
We consider a random variable expressed as the Euclidean distance between an arbitrary point and a random variable uniformly distributed in a closed and bounded set of a three-dimensional Euclidean space. Four cases are considered for this set: a union of disjoint disks, a union of disjoint balls, a union of disjoint line segments, and the boundary of a polyhedron. In the first three cases, we provide closed-form expressions of the cumulative distribution function and the density. In the last...
Dependent online kernel learning with constant number of random Fourier features.
Hu, Zhen; Lin, Ming; Zhang, Changshui
2015-10-01
Traditional online kernel learning analysis assumes independently identically distributed (i.i.d.) about the training sequence. Recent studies reveal that when the loss function is smooth and strongly convex, given T i.i.d. training instances, a constant sampling complexity of random Fourier features is sufficient to ensure O(logT/T) convergence rate of excess risk, which is optimal in online kernel learning up to a logT factor. However, the i.i.d. hypothesis is too strong in practice, which greatly impairs their value. In this paper, we study the sampling complexity of random Fourier features in online kernel learning under non-i.i.d. assumptions. We prove that the sampling complexity under non-i.i.d. settings is also constant, but the convergence rate of excess risk is O(logT/T+ ϕ) , where ϕ is the mixing coefficient measuring the extent of non-i.i.d. of training sequence. We conduct experiments both on artificial and real large-scale data sets to verify our theories. PMID:25616082
Landrum, Carla Jill
There is a shared desire among public and private sectors to produce more reliable predictions, accurate mapping, and appropriate scaling of soil moisture and associated parameters across landscapes. A discrepancy often exists between the scale at which soil hydrologic properties are measured and the scale at which they are modeled for management purposes. Moreover, little is known about the relative importance of hydrologic modeling parameters as soil moisture fluctuates with time. More research is needed to establish which observation scales in space and time are optimal for managing soil moisture variation over large spatial extents and how these scales are affected by fluctuations in soil moisture content with time. This research fuses high resolution geoelectric and light detection and ranging (LiDAR) as auxiliary measures to support sparse direct soil sampling over a 40 hectare inner BluegrassKentucky (USA) landscape. A Veris 3100 was used to measure shallow and deep apparent electrical conductivity (aEC) in tandem with soil moisture sampling on three separate dates with ascending soil moisture contents ranging from plant wilting point to near field capacity. Terrain attributes were produced from 2010 LiDAR ground returns collected at ≤1 m nominal pulse spacing. Exploratory statistics revealed several variables best associate with soil moisture, including terrain features (slope, profile curvature, and elevation), soil physical and chemical properties (calcium, cation exchange capacity, organic matter, clay and sand) and aEC for each date. Multivariate geostatistics, time stability analyses, and spatial regression were performed to characterize scale-dependent soil moisture patterns in space with time to determine which soil-terrain parameters influence soil moisture distribution. Results showed that soil moisture variation was time stable across the landscape and primarily associated with long-range (˜250 m) soil physicochemical properties. When the soils
Burgess, Stephen; Dudbridge, Frank; Thompson, Simon G
2016-05-20
Mendelian randomization is the use of genetic instrumental variables to obtain causal inferences from observational data. Two recent developments for combining information on multiple uncorrelated instrumental variables (IVs) into a single causal estimate are as follows: (i) allele scores, in which individual-level data on the IVs are aggregated into a univariate score, which is used as a single IV, and (ii) a summary statistic method, in which causal estimates calculated from each IV using summarized data are combined in an inverse-variance weighted meta-analysis. To avoid bias from weak instruments, unweighted and externally weighted allele scores have been recommended. Here, we propose equivalent approaches using summarized data and also provide extensions of the methods for use with correlated IVs. We investigate the impact of different choices of weights on the bias and precision of estimates in simulation studies. We show that allele score estimates can be reproduced using summarized data on genetic associations with the risk factor and the outcome. Estimates from the summary statistic method using external weights are biased towards the null when the weights are imprecisely estimated; in contrast, allele score estimates are unbiased. With equal or external weights, both methods provide appropriate tests of the null hypothesis of no causal effect even with large numbers of potentially weak instruments. We illustrate these methods using summarized data on the causal effect of low-density lipoprotein cholesterol on coronary heart disease risk. It is shown that a more precise causal estimate can be obtained using multiple genetic variants from a single gene region, even if the variants are correlated. © 2015 The Authors. Statistics in Medicine published by John Wiley & Sons Ltd. PMID:26661904
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Khan Riaz
2011-08-01
Full Text Available Abstract Background Despite the importance of heavy drinking and alcohol dependence among patients with opiate and cocaine dependence, few studies have evaluated specific interventions within this group. The aim of the present study was to evaluate the impact of screening with the Alcohol Use Disorders Identification Test (AUDIT and of brief intervention (BI on alcohol use in a sample of patients treated for opioid or cocaine dependence in a specialized outpatient clinic. Methods Adult outpatients treated for opioid or cocaine dependence in Switzerland were screened for excessive alcohol drinking and dependence with the AUDIT. Patients with AUDIT scores that indicated excessive drinking or dependence were randomized into two groups--treatment as usual or treatment as usual together with BI--and assessed at 3 months and 9 months. Results Findings revealed a high rate (44% of problematic alcohol use (excessive drinking and dependence among patients with opiate and cocaine dependence. The number of drinks per week decreased significantly between T0 (inclusion and T3 (month 3. A decrease in average AUDIT scores was observed between T0 and T3 and between T0 and T9 (month 9. No statistically significant difference between treatment groups was observed. Conclusions In a substance abuse specialized setting, screening for alcohol use with the AUDIT, followed by feedback on the score, and use of alcohol BI are both possibly useful strategies to induce changes in problematic alcohol use. Definitive conclusions cannot, however, be drawn from the study because of limitations such as lack of a naturalistic group. An important result of the study is the excellent internal consistency of AUDIT in a population treated for opiate or cocaine dependence.
Rezaei, Farzin; Ghaderi, Ebrahim; Mardani, Roya; Hamidi, Seiran; Hassanzadeh, Kambiz
2016-06-01
To date, no medication has been approved as an effective treatment for methamphetamine dependence. Topiramate has attracted considerable attention as a treatment for the dependence on alcohol and stimulants. Therefore, this study aimed to evaluate the effect of topiramate for methamphetamine dependence. This study was a double-blind, randomized, placebo-controlled trial. In the present investigation, 62 methamphetamine-dependent adults were enrolled and randomized into two groups, and received topiramate or a placebo for 10 weeks in escalating doses from 50 mg/day to the target maintenance dose of 200 mg/day. Addiction severity index (ASI) and craving scores were registered every week. The Beck questionnaire was also given to each participant at baseline and every 2 weeks during the treatment. Urine samples were collected at baseline and every 2 weeks during the treatment. Fifty-seven patients completed 10 weeks of the trial. There was no significant difference between both groups in the mean percentage of prescribed capsules taken by the participants. At week six, the topiramate group showed a significantly lower proportion of methamphetamine-positive urine tests in comparison with the placebo group (P = 0.01). In addition, there were significantly lower scores in the topiramate group in comparison with the placebo group in two domains of ASI: drug use severity (P < 0.001) and drug need (P < 0.001). Furthermore, the craving score (duration) significantly declined in the topiramate patients compared to those receiving the placebo. In conclusion, the results of this trial suggest that topiramate may be beneficial for the treatment of methamphetamine dependence. PMID:26751259
A Strong Limit Theorem on Generalized Random Selection for m-valued Random Sequences
Institute of Scientific and Technical Information of China (English)
WANGZhong-zhi; XUFu-xia
2003-01-01
In this paper, a strong limit theorem on gambling strategy for binary Bernoulli sequence, i.e.irregularity theorem, is extended to random selection for dependent m-valued random variables, via using a new method-differentiability on net. Furthermore, by allowing the selection function to take value in finite interval [-M, M], the conception of random selection is generalized.
Wang, Kezhi
2015-06-01
Exact results for the probability density function (PDF) and cumulative distribution function (CDF) of the sum of ratios of products (SRP) and the sum of products (SP) of independent α-μ random variables (RVs) are derived. They are in the form of 1-D integral based on the existing works on the products and ratios of α-μ RVs. In the derivation, generalized Gamma (GG) ratio approximation (GGRA) is proposed to approximate SRP. Gamma ratio approximation (GRA) is proposed to approximate SRP and the ratio of sums of products (RSP). GG approximation (GGA) and Gamma approximation (GA) are used to approximate SP. The proposed results of the SRP can be used to calculate the outage probability (OP) for wireless multihop relaying systems or multiple scattering channels with interference. The proposed results of the SP can be used to calculate the OP for these systems without interference. In addition, the proposed approximate result of the RSP can be used to calculate the OP of the signal-To-interference ratio (SIR) in a multiple scattering system with interference. © 1967-2012 IEEE.
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Joshi Meesha
2010-03-01
Full Text Available Abstract Background An earlier study showed that a week of yoga practice was useful in stress management after a natural calamity. Due to heavy rain and a rift on the banks of the Kosi river, in the state of Bihar in north India, there were floods with loss of life and property. A week of yoga practice was given to the survivors a month after the event and the effect was assessed. Methods Twenty-two volunteers (group average age ± S.D, 31.5 ± 7.5 years; all of them were males were randomly assigned to two groups, yoga and a non-yoga wait-list control group. The yoga group practiced yoga for an hour daily while the control group continued with their routine activities. Both groups' heart rate variability, breath rate, and four symptoms of emotional distress using visual analog scales, were assessed on the first and eighth day of the program. Results There was a significant decrease in sadness in the yoga group (p Conclusions A week of yoga can reduce feelings of sadness and possibly prevent an increase in anxiety in flood survivors a month after the calamity. Trial Registration Clinical Trials Registry of India: CTRI/2009/091/000285
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Ahmet Kuzu
2014-01-01
Full Text Available This paper proposes two novel master-slave configurations that provide improvements in both control and communication aspects of teleoperation systems to achieve an overall improved performance in position control. The proposed novel master-slave configurations integrate modular control and communication approaches, consisting of a delay regulator to address problems related to variable network delay common to such systems, and a model tracking control that runs on the slave side for the compensation of uncertainties and model mismatch on the slave side. One of the configurations uses a sliding mode observer and the other one uses a modified Smith predictor scheme on the master side to ensure position transparency between the master and slave, while reference tracking of the slave is ensured by a proportional-differentiator type controller in both configurations. Experiments conducted for the networked position control of a single-link arm under system uncertainties and randomly varying network delays demonstrate significant performance improvements with both configurations over the past literature.
Radial dependence of line profile variability in seven O9-B0.5 stars
Martins, F.; Marcolino, W.; Hillier, D. J.; Donati, J.-F.; Bouret, J.-C.
2015-02-01
Context. Massive stars show a variety of spectral variabilities: discrete absorption components in UV P-Cygni profiles, optical line profile variability, X-ray variability, and radial velocity modulations. Aims: Our goal is to study the spectral variability of single OB stars to better understand the relation between photospheric and wind variability. For that, we rely on high spectral resolution and on high signal-to-noise ratio optical spectra collected with the spectrograph NARVAL on the Télescope Bernard Lyot at Pic du Midi. Methods: We investigated the variability of twelve spectral lines by means of the temporal variance spectrum. The selected lines probe the radial structure of the atmosphere from the photosphere to the outer wind. We also performed a spectroscopic analysis with atmosphere models to derive the stellar and wind properties and to constrain the formation region of the selected lines. Results: We show that variability is observed in the wind lines of all bright giants and supergiants on a daily timescale. Lines formed in the photosphere are sometimes variable, sometimes not. The dwarf stars do not show any sign of variability. If variability is observed on a daily timescale, it can also (but not always) be observed on hourly timescales, albeit with lower amplitude. There is a very clear correlation between amplitude of the variability and fraction of the line formed in the wind. Strong anti-correlations between the different parts of the temporal variance spectrum are observed. Conclusions: Our results indicate that variability is stronger in lines formed in the wind. A link between photospheric and wind variability is not obvious from our study, since wind variability is observed regardless of the level of photospheric variability. Different photospheric lines also show different degrees of variability. Appendices are available in electronic form at http://www.aanda.org
Spectral Variability of Quasars in the Sloan Digital Sky Survey. I: Wavelength Dependence
Wilhite, B C; Kron, R G; Schneider, D P; Pereyra, N; Brunner, R J; Richards, G T; Brinkmann, J; Wilhite, Brian C.; Berk, Daniel E. Vanden; Kron, Richard G.; Schneider, Donald P.; Pereyra, Nicholas; Brunner, Robert J.; Richards, Gordon T.; Brinkmann, Jonathan V.
2005-01-01
Sloan Digital Sky Survey (SDSS) repeat spectroscopic observations have resulted in multiple-epoch spectroscopy for roughly 2500 quasars observed more than 50 days apart. From this sample, we identify 315 quasars that have varied significantly between observations. We create an ensemble difference spectrum (bright phase minus faint phase) covering rest-frame wavelengths from 1000 to 6000 Angstroms. This average difference spectrum is bluer than the average single-epoch quasar spectrum; a power-law fit to the difference spectrum yields a spectral index alpha_lambda = -2.00, compared to an index of alpha_lambda = -1.35 for the single-epoch spectrum. The strongest emission lines vary only 30% as much as the continuum. Due to the lack of variability of the lines, measured photometric color is not always bluer in brighter phases, but depends on redshift and the filters used. Lastly, the difference spectrum is bluer than the ensemble quasar spectrum only for lambda_rest < 2500 Angstroms, indicating that the varia...
Energy-dependent variability and the origin of the soft X-ray excess in AGN
Gierlinski, M; Done, Chris; Gierlinski, Marek
2006-01-01
The origin of the soft excess seen in many AGN below ~1 keV is still an unsolved problem. It is unlikely to represent a true continuum component as its characteristic 'temperature' shows a remarkable constancy over a wide range of AGN luminosity and black hole mass. This instead favours an association with atomic processes, in particular with the increase in opacity between 0.7-2 keV associated with partially ionized O and Fe. The opacity jump can give rise to a soft excess either through reflection or transmission, and both scenarios can fit the spectra equally well as long as there is strong velocity shear to smear out the characteristic narrow atomic features. Here we use orthogonal constraints from the energy-dependent variability. The rms spectra seen in XMM-Newton AGN data often show a broad peak between 0.7-2 keV. We show that the absorption model can explain the data well if the ionization state of the smeared absorption responds to luminosity changes in the continuum.
负相伴随机变量的非经典重对数律%A NONCLASSICAL LAW OF ITERATED LOGARITHM FOR NEGATIVELY ASSOCIATED RANDOM VARIABLES
Institute of Scientific and Technical Information of China (English)
蒋烨
2003-01-01
A nonclassical law of iterated logarithm that holds for a stationary negativelyassociated sequence of random variables with finite variance is proved in this paperThe proof isbased on a Rosenthal type maximal inequality and the subsequence metlodThis result extendsthe work of Klesov,Rosalsky (2001) and Shao,Su (1999).
Radial dependence of line profile variability in seven O9--B0.5 stars
Martins, F; Hillier, D J; Donati, J -F; Bouret, J -C
2014-01-01
Massive stars show a variety of spectral variability: presence of discrete absorption components in UV P-Cygni profiles, optical line profile variability, X-ray variability, radial velocity modulations. Our goal is to study the spectral variability of single OB stars to better understand the relation between photospheric and wind variability. For that, we rely on high spectral resolution, high signal-to-noise ratio optical spectra collected with the spectrograph NARVAL on the Telescope Bernard Lyot at Pic du Midi. We investigate the variability of twelve spectral lines by means of the Temporal Variance Spectrum (TVS). The selected lines probe the radial structure of the atmosphere, from the photosphere to the outer wind. We also perform a spectroscopic analysis with atmosphere models to derive the stellar and wind properties, and to constrain the formation region of the selected lines. We show that variability is observed in the wind lines of all bright giants and supergiants, on a daily timescale. Lines form...
Alaskan soil carbon stocks: spatial variability and dependence on environmental factors
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U. Mishra
2012-05-01
Full Text Available The direction and magnitude of soil organic carbon (SOC changes in response to climate change depend on the spatial and vertical distributions of SOC. We estimated spatially-resolved SOC stocks from surface to C horizon, distinguishing active-layer and permafrost-layer stocks, based on geospatial analysis of 472 soil profiles and spatially referenced environmental variables for Alaska. Total Alaska state-wide SOC stock was estimated to be 77 Pg, with 61% in the active-layer, 27% in permafrost, and 12% in non-permafrost soils. Prediction accuracy was highest for the active-layer as demonstrated by highest ratio of performance to deviation (1.5. Large spatial variability was predicted, with whole-profile, active-layer, and permafrost-layer stocks ranging from 1–296 kg C m^{−2}, 2–166 kg m^{−2}, and 0–232 kg m^{−2}, respectively. Temperature and soil wetness were found to be primary controllers of whole-profile, active-layer, and permafrost-layer SOC stocks. Secondary controllers, in order of importance, were: land cover type, topographic attributes, and bedrock geology. The observed importance of soil wetness rather than precipitation on SOC stocks implies that the poor representation of high-latitude soil wetness in Earth System Models may lead to large uncertainty in predicted SOC stocks under future climate change scenarios. Under strict caveats described in the text and assuming temperature changes from the A1B Intergovernmental Panel on Climate Change emissions scenario, our geospatial model indicates that the equilibrium average 2100 Alaska active-layer depth could deepen by 11 cm, resulting in a thawing of 13 Pg C currently in permafrost. The equilibrium SOC loss associated with this warming would be highest under continuous permafrost (31%, followed by discontinuous (28%, isolated (24.3%, and sporadic (23.6% permafrost areas. Our high resolution mapping of soil carbon stock reveals the potential
Alaskan soil carbon stocks: spatial variability and dependence on environmental factors
Directory of Open Access Journals (Sweden)
U. Mishra
2012-09-01
Full Text Available The direction and magnitude of soil organic carbon (SOC changes in response to climate change depend on the spatial and vertical distributions of SOC. We estimated spatially resolved SOC stocks from surface to C horizon, distinguishing active-layer and permafrost-layer stocks, based on geospatial analysis of 472 soil profiles and spatially referenced environmental variables for Alaska. Total Alaska state-wide SOC stock was estimated to be 77 Pg, with 61% in the active-layer, 27% in permafrost, and 12% in non-permafrost soils. Prediction accuracy was highest for the active-layer as demonstrated by highest ratio of performance to deviation (1.5. Large spatial variability was predicted, with whole-profile, active-layer, and permafrost-layer stocks ranging from 1–296 kg C m^{−2}, 2–166 kg m^{−2}, and 0–232 kg m^{−2}, respectively. Temperature and soil wetness were found to be primary controllers of whole-profile, active-layer, and permafrost-layer SOC stocks. Secondary controllers, in order of importance, were found to be land cover type, topographic attributes, and bedrock geology. The observed importance of soil wetness rather than precipitation on SOC stocks implies that the poor representation of high-latitude soil wetness in Earth system models may lead to large uncertainty in predicted SOC stocks under future climate change scenarios. Under strict caveats described in the text and assuming temperature changes from the A1B Intergovernmental Panel on Climate Change emissions scenario, our geospatial model indicates that the equilibrium average 2100 Alaska active-layer depth could deepen by 11 cm, resulting in a thawing of 13 Pg C currently in permafrost. The equilibrium SOC loss associated with this warming would be highest under continuous permafrost (31%, followed by discontinuous (28%, isolated (24.3%, and sporadic (23.6% permafrost areas. Our high-resolution mapping of soil carbon stock reveals the
Continuous infusion of propofol at variable rates in a time dependent in cats
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Felipe Comassetto
2015-04-01
Full Text Available Felines biotransforms propofol slowly developing cumulative effect. The aim this study was to develop a scheme of continuous infusion of propofol at time dependent variable rate in cats. Sixteen healthy female cats undergoing elective ovariohysterectomy and received as premedication dexmedetomidine (2.5 ?g/kg, methadone (0.5 mg/kg and ketamine (0.5 mg/kg administrated at intramuscular rote. After 15 minutes , the animals were allocated into two groups : Fixed Rate (GFR, which received propofol 4mg/kg, followed by continuous infusion (CI at the rate of 0.3 mg/kg/min for 60 minutes; and Variable Rate (GVR receiving the same induction protocol exchange with the IC starting at 0.3 mg/ kg/min for 10 minutes, 0.25 mg/kg/min up to 25 minutes, 0.2 mg/ kg/min up to 45 minutes and 0.15 mg/kg /min to 60 min of infusion based on simulation STAMPUMP®. We evaluated the cardiac frequency (HR, respiratory rate (RR, systolic blood pressure (SBP and maintenance of anesthesia during 60 minutes of infusion , as well as time to extubation, sternal recumbency and to full recovery. We observed similar anesthesia in both groups, but the GVR was used propofol least 30% for maintenance anesthesia. There was a reduction of HR and f in both groups after induction, with one animal the GFR developed apnea during all periods evaluated . Decreased SBP in GFR at all times in relation to the baseline, as the GVR, SBP decreased in just a moment. There was no significant difference between groups with respect to time to extubation (GFR 43.2 ± 19.5 min and 30.7 ± 13.2 min GVR , deambulation ( GFR 60.7 ± 29.6 min and 41.6 ± GVR 17.2 min and total recovery (GFR 136 ± 34.3 min and 101.5 ± 29.6 min GVR . We conclude that the two techniques keeps similar anesthetic plans, being safe for use in cats, and that the rate has varied propofol consumption 30 % lower.
Schneider, Brooke C; Moritz, Steffen; Hottenrott, Birgit; Reimer, Jens; Andreou, Christina; Jelinek, Lena
2016-04-30
Association Splitting, a novel cognitive intervention, was tested in patients with alcohol dependence as an add-on intervention in an initial randomized controlled trial. Preliminary support for Association Splitting has been found in patients with obsessive-compulsive disorder, as well as in an online pilot study of patients with alcohol use disorders. The present variant sought to reduce craving by strengthening neutral associations with alcohol-related stimuli, thus, altering cognitive networks. Eighty-four inpatients with verified diagnoses of alcohol dependence, who were currently undergoing inpatient treatment, were randomly assigned to Association Splitting or Exercise Therapy. Craving was measured at baseline, 4-week follow-up, and six months later with the Obsessive-Compulsive Drinking Scale (primary outcome) and the Alcohol Craving Questionnaire. There was no advantage for Association Splitting after three treatment sessions relative to Exercise Therapy. Among Association Splitting participants, 51.9% endorsed a subjective decline in craving and 88.9% indicated that they would use Association Splitting in the future. Despite high acceptance, an additional benefit of Association Splitting beyond standard inpatient treatment was not found. Given that participants were concurrently undergoing inpatient treatment and Association Splitting has previously shown moderate effects, modification of the study design may improve the potential to detect significant effects in future trials. PMID:27086250
Directory of Open Access Journals (Sweden)
Ahmadi-Abhari Seyed Ali
2003-11-01
Full Text Available Abstract Background Results of preclinical studies suggest that the GABAB receptor agonist baclofen may be useful in treatment of opioid dependence. This study was aimed at assessing the possible efficacy of baclofen for maintenance treatment of opioid dependence. Methods A total of 40 opioid-dependent patients were detoxified and randomly assigned to receive baclofen (60 mg/day or placebo in a 12-week, double blind, parallel-group trial. Primary outcome measure was retention in treatment. Secondary outcome measures included opioids and alcohol use according to urinalysis and self-report ratings, intensity of opioid craving assessed with a visual analogue scale, opioid withdrawal symptoms as measured by the Short Opiate Withdrawal Scale and depression scores on the Hamilton inventory. Results Treatment retention was significantly higher in the baclofen group. Baclofen also showed a significant superiority over placebo in terms of opiate withdrawal syndrome and depressive symptoms. Non-significant, but generally favorable responses were seen in the baclofen group with other outcome measures including intensity of opioid craving and self-reported opioid and alcohol use. However, no significant difference was seen in the rates of opioid-positive urine tests. Additionally, the drug side effects of the two groups were not significantly different. Conclusion The results support further study of baclofen in the maintenance treatment of opioid dependence.
Schellenberg, Ruediger; Saller, Reinhard; Hess, Lorenzo; Melzer, Jörg; Zimmermann, Christian; Drewe, Juergen; Zahner, Catherine
2012-01-01
Extracts from Cimicifuga racemosa (CR, synonym Actaea racemosa) have shown efficacy in trials in women with menopausal symptoms. Yet, dose dependency remains unclear. Therefore, 180 female outpatients with climacteric complaints were treated for 12 weeks in a randomized, double-blind, placebo-controlled, 3-armed trial (CR extract Ze 450 in 6.5 mg or 13.0 mg, or placebo). Primary outcome was the difference in menopausal symptoms (vasomotor, psychological, and somatic), assessed by the Kupperman Menopausal Index between baseline and week 12. Secondary efficacy variables were patients' self-assessments of general quality of life (QoL), responder rates, and safety. Compared to placebo, patients receiving Ze 450 showed a significant reduction in the severity of menopausal symptoms in a dose-dependent manner from baseline to endpoint (mean absolute differences 17.0 (95% CI 14.65-19.35) score points, P < 0.0001 for 13.0 mg; mean absolute differences 8.47 (95% CI 5.55-11.39) score points, P = 0.0003 for 6.5 mg). QoL and responder rates corresponded with the main endpoint. Changes in menopausal symptoms and QoL were inversely correlated. Reported adverse events and clinical laboratory testing did not raise safety concerns. The CR extract Ze 450 is an effective and well-tolerated nonhormonal alternative to hormone treatment for symptom relief in menopausal women. PMID:23346194
Directory of Open Access Journals (Sweden)
Ruediger Schellenberg
2012-01-01
Full Text Available Extracts from Cimicifuga racemosa (CR, synonym Actaea racemosa have shown efficacy in trials in women with menopausal symptoms. Yet, dose dependency remains unclear. Therefore, 180 female outpatients with climacteric complaints were treated for 12 weeks in a randomized, double-blind, placebo-controlled, 3-armed trial (CR extract Ze 450 in 6.5 mg or 13.0 mg, or placebo. Primary outcome was the difference in menopausal symptoms (vasomotor, psychological, and somatic, assessed by the Kupperman Menopausal Index between baseline and week 12. Secondary efficacy variables were patients’ self-assessments of general quality of life (QoL, responder rates, and safety. Compared to placebo, patients receiving Ze 450 showed a significant reduction in the severity of menopausal symptoms in a dose-dependent manner from baseline to endpoint (mean absolute differences 17.0 (95% CI 14.65–19.35 score points, P<0.0001 for 13.0 mg; mean absolute differences 8.47 (95% CI 5.55–11.39 score points, P=0.0003 for 6.5 mg. QoL and responder rates corresponded with the main endpoint. Changes in menopausal symptoms and QoL were inversely correlated. Reported adverse events and clinical laboratory testing did not raise safety concerns. The CR extract Ze 450 is an effective and well-tolerated nonhormonal alternative to hormone treatment for symptom relief in menopausal women.
The derivative-dependent functional variable separation for the evolution equations
Institute of Scientific and Technical Information of China (English)
Zhang Shun-Li; Lou Sen-Yue; Qu Chang-Zheng
2006-01-01
This paper studies variable separation of the evolution equations via the generalized conditional symmetry. To illustrate, we classify the extended nonlinear wave equation utt = A(u,ux)uxx+B(u,ux,ut) which admits the derivativedependent functional separable solutions (DDFSSs). We also extend the concept of the DDFSS to cover other variable separation approaches.
Delgado Saa, Jaime F.; de Pesters, Adriana; Cetin, Mujdat
2016-06-01
Objective. In this work we propose the use of conditional random fields with long-range dependencies for the classification of finger movements from electrocorticographic recordings. Approach. The proposed method uses long-range dependencies taking into consideration time-lags between the brain activity and the execution of the motor task. In addition, the proposed method models the dynamics of the task executed by the subject and uses information about these dynamics as prior information during the classification stage. Main results. The results show that incorporating temporal information about the executed task as well as incorporating long-range dependencies between the brain signals and the labels effectively increases the system’s classification performance compared to methods in the state of art. Significance. The method proposed in this work makes use of probabilistic graphical models to incorporate temporal information in the classification of finger movements from electrocorticographic recordings. The proposed method highlights the importance of including prior information about the task that the subjects execute. As the results show, the combination of these two features effectively produce a significant improvement of the system’s classification performance.
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Azarekhsh Mokri
2009-08-01
Full Text Available Introduction: In this research, researchers want to study the effectiveness of Olanzapine on reduction of substance abuse relapse among people who are dependent to opioid material, merely. Method: A randomized clinical trial was designed. The population was opioid dependence subjects (only men that were diagnosed based on DSM-IV TR criteria, and referred to national center of addiction studies clinic. Detoxification was done by using of Clonidine, Clonazepam, Disiklomin, and NSAIDS within7 through 10 days. In second stage, the Patients who were referred to the clinic those men who had satisfied criterions selected. Demographic forms, testimonial certificate, Addiction Severity Index, Beck Depression Questionnaire, Zung Self report anxiety test administered among selected sample. Sample divided to two groups (placebo and Olanzapine the research last for 8 weeks. Results: the results showed that addiction severity reduced in both groups, but there was not significant difference in reduction of addiction severity between two groups. There was significant difference in depression and anxiety among mean scores of base line and follow up in both groups but there was not significant difference between two groups in follow up measures. Conclusion: Altogether, the results did not confirm the effectiveness of Olanzapine on maintenance treatment of opioid dependence.
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Keita eMitani
2016-06-01
Full Text Available The processing of time intervals is fundamental for sensorimotor and cognitive functions. Perceptual and motor timing are often performed concurrently (e.g., playing a musical instrument. Although previous studies have shown the influence of body movements on time perception, how we perceive self-produced time intervals has remained unclear. Furthermore, it has been suggested that the timing mechanisms are distinct for the sub- and suprasecond ranges. Here, we compared perceptual performances for self-produced and passively presented time intervals in random contexts (i.e., multiple target intervals presented in a session across the sub- and suprasecond ranges (Experiment 1 and within the sub- (Experiment 2 and suprasecond (Experiment 3 ranges, and in a constant context (i.e., a single target interval presented in a session in the sub- and suprasecond ranges (Experiment 4. We show that self-produced time intervals were perceived as shorter and more variable across the sub- and suprasecond ranges and within the suprasecond range but not within the subsecond range in a random context. In a constant context, the self-produced time intervals were perceived as more variable in the suprasecond range but not in the subsecond range. The impairing effects indicate that motor timing interferes with perceptual timing. The dependence of impairment on temporal contexts suggests multiple timing mechanisms for the subsecond and suprasecond ranges. In addition, violation of the scalar property (i.e., a constant variability to target interval ratio was observed between the sub- and suprasecond ranges. The violation was clearer for motor timing than for perceptual timing. This suggests that the multiple timing mechanisms for the sub- and suprasecond ranges overlap more for perception than for motor. Moreover, the central tendency effect (i.e., where shorter base intervals are overestimated and longer base intervals are underestimated disappeared with subsecond
Mitani, Keita; Kashino, Makio
2016-01-01
The processing of time intervals is fundamental for sensorimotor and cognitive functions. Perceptual and motor timing are often performed concurrently (e.g., playing a musical instrument). Although previous studies have shown the influence of body movements on time perception, how we perceive self-produced time intervals has remained unclear. Furthermore, it has been suggested that the timing mechanisms are distinct for the sub- and suprasecond ranges. Here, we compared perceptual performances for self-produced and passively presented time intervals in random contexts (i.e., multiple target intervals presented in a session) across the sub- and suprasecond ranges (Experiment 1) and within the sub- (Experiment 2) and suprasecond (Experiment 3) ranges, and in a constant context (i.e., a single target interval presented in a session) in the sub- and suprasecond ranges (Experiment 4). We show that self-produced time intervals were perceived as shorter and more variable across the sub- and suprasecond ranges and within the suprasecond range but not within the subsecond range in a random context. In a constant context, the self-produced time intervals were perceived as more variable in the suprasecond range but not in the subsecond range. The impairing effects indicate that motor timing interferes with perceptual timing. The dependence of impairment on temporal contexts suggests multiple timing mechanisms for the subsecond and suprasecond ranges. In addition, violation of the scalar property (i.e., a constant variability to target interval ratio) was observed between the sub- and suprasecond ranges. The violation was clearer for motor timing than for perceptual timing. This suggests that the multiple timing mechanisms for the sub- and suprasecond ranges overlap more for perception than for motor. Moreover, the central tendency effect (i.e., where shorter base intervals are overestimated and longer base intervals are underestimated) disappeared with motor timing within the
International Nuclear Information System (INIS)
The dependence of the long-term optical/UV variability on the spectral and fundamental physical parameters for radio-quiet active galactic nuclei (AGNs) is investigated. The multi-epoch-repeated photometric scanning data in the Stripe-82 region of the Sloan Digital Sky Survey (SDSS) are exploited for two comparative AGN samples (mostly quasars) selected therein: a broad-line Seyfert 1 (BLS1) type sample and a narrow-line Seyfert 1 (NLS1) type AGN sample within redshifts 0.3-0.8. Their spectral parameters are derived from the SDSS spectroscopic data. It is found that on rest-frame timescales of several years the NLS1-type AGNs show systematically smaller variability compared to the BLS1-type AGNs. In fact, the variability amplitude is found to correlate, though only moderately, with the eigenvector 1 parameters, i.e., the smaller the Hβ linewidth, the weaker the [O III] and the stronger the Fe II emission, the smaller the variability amplitude. Moreover, an interesting inverse correlation is found between the variability and the Eddington ratio, which is perhaps more fundamental. The previously known dependence of the variability on luminosity is not significant, and the dependence on black hole mass-as claimed in recent papers and also present in our data-fades out when controlling for the Eddington ratio in the correlation analysis, though these may be partly due to the limited ranges of luminosity and black hole mass of our samples. Our result strongly supports that an accretion disk is likely to play a major role in producing the optical/UV variability.
Nonparametric regression for dependent data in the errors-in-variables problem
Toshio Honda
2009-01-01
We consider the nonparametric estimation of the regression functions for dependent data. Suppose that the covariates are observed with additive errors in the data and we employ nonparametric deconvolution kernel techniques to estimate the regression functions in this paper. We investigate how the strength of time dependence affects the asymptotic properties of the local constant and linear estimators. We treat both short-range dependent and long-range dependent linear processes in a unified w...
Peter M Spieth; Güldner, Andreas; Uhlig, Christopher; Bluth, Thomas; Kiss, Thomas; Schultz, Marcus J.; Pelosi, Paolo; Koch, Thea; Gama de Abreu, Marcelo
2014-01-01
Background General anesthesia usually requires mechanical ventilation, which is traditionally accomplished with constant tidal volumes in volume- or pressure-controlled modes. Experimental studies suggest that the use of variable tidal volumes (variable ventilation) recruits lung tissue, improves pulmonary function and reduces systemic inflammatory response. However, it is currently not known whether patients undergoing open abdominal surgery might benefit from intraoperative variable ventila...
Directory of Open Access Journals (Sweden)
Chang Dennis
2011-07-01
Full Text Available Abstract Background Chronic work-related stress is a significant and independent risk factor for cardiovascular and metabolic diseases and associated mortality, particularly when compounded by a sedentary work environment. Heart rate variability (HRV provides an estimate of parasympathetic and sympathetic autonomic control, and can serve as a marker of physiological stress. Hatha yoga is a physically demanding practice that can help to reduce stress; however, time constraints incurred by work and family life may limit participation. The purpose of the present study is to determine if a 10-week, worksite-based yoga program delivered during lunch hour can improve resting HRV and related physical and psychological parameters in sedentary office workers. Methods and design This is a parallel-arm RCT that will compare the outcomes of participants assigned to the experimental treatment group (yoga to those assigned to a no-treatment control group. Participants randomized to the experimental condition will engage in a 10-week yoga program delivered at their place of work. The yoga sessions will be group-based, prescribed three times per week during lunch hour, and will be led by an experienced yoga instructor. The program will involve teaching beginner students safely and progressively over 10 weeks a yoga sequence that incorporates asanas (poses and postures, vinyasa (exercises, pranayama (breathing control and meditation. The primary outcome of this study is the high frequency (HF spectral power component of HRV (measured in absolute units; i.e. ms2, a measure of parasympathetic autonomic control. Secondary outcomes include additional frequency and time domains of HRV, and measures of physical functioning and psychological health status. Measures will be collected prior to and following the intervention period, and at 6 months follow-up to determine the effect of intervention withdrawal. Discussion This study will determine the effect of worksite
International Nuclear Information System (INIS)
The primary aim of this paper is to evaluate the probabilistic fatigue crack propagation models using the residual of a random variable and to present the probabilistic model fit for the probabilistic fatigue crack growth behavior in Mg-Al-Zn alloys under maximum load conditions. The models used in this study were prepared by applying a random variable to empirical fatigue crack propagation models such as the Paris-Erdogan model, Walker model, Forman model, and modified Forman model. It was verified that the good models for describing the stochastic variation of the fatigue crack propagation behavior in Mg-Al-Zn alloys under maximum load conditions were the ‘probabilistic Paris-Erdogan model’ and ‘probabilistic Walker model’. The influence of the maximum load conditions on the stochastic variation of fatigue crack growth is also considered
Energy Technology Data Exchange (ETDEWEB)
Choi, Seon Soon [Sahmyook University, Seoul (Korea, Republic of)
2015-01-15
The primary aim of this paper is to evaluate the probabilistic fatigue crack propagation models using the residual of a random variable and to present the probabilistic model fit for the probabilistic fatigue crack growth behavior in Mg-Al-Zn alloys under maximum load conditions. The models used in this study were prepared by applying a random variable to empirical fatigue crack propagation models such as the Paris-Erdogan model, Walker model, Forman model, and modified Forman model. It was verified that the good models for describing the stochastic variation of the fatigue crack propagation behavior in Mg-Al-Zn alloys under maximum load conditions were the ‘probabilistic Paris-Erdogan model’ and ‘probabilistic Walker model’. The influence of the maximum load conditions on the stochastic variation of fatigue crack growth is also considered.
Institute of Scientific and Technical Information of China (English)
张永进; 汪忠志
2016-01-01
应用正交变换将对称矩阵对角化，基于随机向量正交变换后独立性的不变性及矩阵迹相关性质，给出一个关于对称矩阵经随机变换后方差的证明，并将该结论推广到更一般情形。%Based on the Theorem in a reference book, a symmetric matrix is diagonalized by orthogonal transformation first. Because of the invariance property of independence when a random variable is transformed through orthogonal mean, a proof for variance of random variable after stochastic transformation of symmetric matrix is presented by applying the property of trace of matrix. Secondly, a general conclusion for the theorem is studied.
Nakahara, Kenji
2012-01-01
We show uniform estimates for distributions of the sum of i.i.d. random variables in the threshold case. Rozovskii showed several uniform estimates but the speed of convergence was not known. Our main uniform estimate implies a speed of convergence. We also compare our estimates with Nagaev's estimate which is valid in the non-threshold case and, moreover, give a necessary and sufficient condition for Nagaev's estimate to hold in the threshold case.
Nam, Sungsik
2014-08-01
The joint statistics of partial sums of ordered random variables (RVs) are often needed for the accurate performance characterization of a wide variety of wireless communication systems. A unified analytical framework to determine the joint statistics of partial sums of ordered independent and identically distributed (i.i.d.) random variables was recently presented. However, the identical distribution assumption may not be valid in several real-world applications. With this motivation in mind, we consider in this paper the more general case in which the random variables are independent but not necessarily identically distributed (i.n.d.). More specifically, we extend the previous analysis and introduce a new more general unified analytical framework to determine the joint statistics of partial sums of ordered i.n.d. RVs. Our mathematical formalism is illustrated with an application on the exact performance analysis of the capture probability of generalized selection combining (GSC)-based RAKE receivers operating over frequency-selective fading channels with a non-uniform power delay profile. © 1991-2012 IEEE.
Bornstein, Robert F.
2007-01-01
Presents a reply by Robert Bornstein to comments from Chronister and regarding his article, "The complex relationship between dependency and domestic violence: Converging psychological factors and social forces." In addition to raising some important issues regarding the link between dependency and domestic violence, the comments by Chronister and…
Time-dependent excitation and ionization modelling of absorption-line variability due to GRB080310
DEFF Research Database (Denmark)
Vreeswijk, P.M.; De Cia, A.; Jakobsson, P.;
2013-01-01
We model the time-variable absorption of Feii, Feiii, Siii, Cii and Crii detected in Ultraviolet and Visual Echelle Spectrograph (UVES) spectra of gamma-ray burst (GRB) 080310, with the afterglow radiation exciting and ionizing the interstellar medium in the host galaxy at a redshift of z = 2.427...
Individual variability of 90Sr deposition depending on sample genotype homogeneity
International Nuclear Information System (INIS)
The study on the range of individual changes in the individual variability of the 90Sr skeleton metabolism in the CBA mice (including sex and age peculiarities) as well as its comparison (by published data) with the range of variability in the outbred animals and small mammals from the natural population living in the epicenter of the Earth-Ural radioactive trail is carried out. The CBA mature mice were subjected intraperitoneally to the 1.0 ml 90Sr solution. The radiometry results showed that soft tissues contained less than 0.4 % from the radionuclide injected quantity, which constitutes 1 % 90Sr contained in the skeleton. Absence of sex differences in the 90Sr deposition and availability of age differences was registered. The variations in the radionuclide accumulation induced do not exceed two times. The analysis of the 90Sr individual deposition variability range in the genetically homogeneous animals in comparison with the outbread nonlinear ones and voles from the natural population indicated the variability of the 90Sr accumulation indices with increase in the samples genotype heterogeneity
Directory of Open Access Journals (Sweden)
Jonna C Sandberg
Full Text Available Whole grain has shown potential to prevent obesity, cardiovascular disease and type 2 diabetes. Possible mechanism could be related to colonic fermentation of specific indigestible carbohydrates, i.e. dietary fiber (DF. The aim of this study was to investigate effects on cardiometabolic risk factors and appetite regulation the next day when ingesting rye kernel bread rich in DF as an evening meal.Whole grain rye kernel test bread (RKB or a white wheat flour based bread (reference product, WWB was provided as late evening meals to healthy young adults in a randomized cross-over design. The test products RKB and WWB were provided in two priming settings: as a single evening meal or as three consecutive evening meals prior to the experimental days. Test variables were measured in the morning, 10.5-13.5 hours after ingestion of RKB or WWB. The postprandial phase was analyzed for measures of glucose metabolism, inflammatory markers, appetite regulating hormones and short chain fatty acids (SCFA in blood, hydrogen excretion in breath and subjective appetite ratings.With the exception of serum CRP, no significant differences in test variables were observed depending on length of priming (P>0.05. The RKB evening meal increased plasma concentrations of PYY (0-120 min, P<0.001, GLP-1 (0-90 min, P<0.05 and fasting SCFA (acetate and butyrate, P<0.05, propionate, P = 0.05, compared to WWB. Moreover, RKB decreased blood glucose (0-120 min, P = 0.001, serum insulin response (0-120 min, P<0.05 and fasting FFA concentrations (P<0.05. Additionally, RKB improved subjective appetite ratings during the whole experimental period (P<0.05, and increased breath hydrogen excretion (P<0.001, indicating increased colonic fermentation activity.The results indicate that RKB evening meal has an anti-diabetic potential and that the increased release of satiety hormones and improvements of appetite sensation could be beneficial in preventing obesity. These effects could
International Nuclear Information System (INIS)
Field and temperature dependent electron transport properties of random network single walled carbon nanotubes (SWCNTs) and multi walled carbon nanotubes (MWCNTs) were investigated and compared. The electrical characterizations of drop casted CNT samples were done by two probe measurements by varying temperatures from 80 K to 300 K in the field region 1–400 V cm−1. The charge transport mechanisms at low (<3.5 V) and high (>3.5 V) fields were analyzed from measured I–V characteristic curves at various temperatures (<300 K) with respect to applied field. At low field, the ohmic behavior was observed and at high field the charge transport appears to be Poole–Frenkel type in both types of CNTs network. Electron–electron and electron–phonon scatterings in the localized defect states dominate in SWCNTs, whereas in MWCNTs the delocalization of charge carriers as well as the scattering centers is responsible due to the presence of inner shells. Because of the different nature of chirality in random network, the SWCNTs displayed lower conduction when compared to MWCNTs. The variation in Poole–Frenkel co-efficient (β) (SWCNTs-0.193 × 10−22; MWCNTs-0.089 07 × 10−22 J V1/2 cm−1/2), activation energy (SWCNTs-90 meV; MWCNTs-60 meV for field of 7 V1/2 cm−1/2) and trap energy levels (SWCNTs-109 meV; MWCNTs-37 meV) are discussed for both SWCNTs and MWCNTs. (paper)
De Ruiter, Naomi M. P.; Den Hartigh, Ruud J. R.; Cox, Ralf F. A.; Van Geert, Paul L. C.; Kunnen, E. Saskia
2015-01-01
Research regarding the variability of state self-esteem (SSE) commonly focuses on the magnitude of variability. In this article we provide the first empirical test of the temporalstructure of SSE as a real-time process during parent-adolescent interactions. We adopt a qualitative phenomenological ap
International Nuclear Information System (INIS)
To develop constitutive models to represent the thermomechanically chemically coupled behaviour of curing resins, vulcanizing elastomers or melting and crystallizing polymers the technique of DSC is extremely helpful. In the present study, the method of TMDSC is interpreted and evaluated in the context of thermodynamics with internal state variables. The balance equation of energy and the dissipation principle in the form of the Clausius-Duhem inequality form the theoretical basis of our study. Since the pressure and the temperature are the external variables in DSC, the specific Gibbs free energy is used as thermodynamic potential. It depends on temperature, stress and a set of internal state variables to represent the microstructure of the material on a phenomenological basis. The temperature- and internal variable-induced changes in the Gibbs free energy are approximated by a Taylor series up to second order terms. As a substantial result of this work, closed-form expressions for the dynamic calorimetric response due to harmonic temperature perturbations and the frequency-dependent complex heat capacity are derived. The theory allows a physical interpretation of the complex heat capacity and its underlying phenomena and is in accordance with experimental observations from literature.
International Nuclear Information System (INIS)
A modified generalized, rational harmonic balance method is used to construct approximate frequency-amplitude relations for a conservative nonlinear singular oscillator in which the restoring force is inversely proportional to the dependent variable. The procedure is used to solve the nonlinear differential equation approximately. The approximate frequency obtained using this procedure is more accurate than those obtained using other approximate methods and the discrepancy between the approximate frequency and the exact one is lower than 0.40%
Hoang, Hanh H.; Nickerson, Nicholas N.; Lee, Vincent T.; Kazimirova, Anastasia; Chami, Mohamed; Pugsley, Anthony P.; Lory, Stephen
2011-01-01
ABSTRACT In Gram-negative bacteria, the Lol and Bam machineries direct the targeting of lipidated and nonlipidated proteins, respectively, to the outer membrane (OM). Using Pseudomonas aeruginosa strains with depleted levels of specific Bam and Lol proteins, we demonstrated a variable dependence of different OM proteins on these targeting pathways. Reduction in the level of BamA significantly affected the ability of the β-barrel membrane protein OprF to localize to the OM, while the targeting...
Liu, Shijing; Lane, Scott D.; Schmitz, Joy M.; Green, Charles E.; Cunningham, Kathryn A.; Moeller, F. Gerard
2011-01-01
Neuroimaging data suggest that impaired performance on response inhibition and information processing tests in cocaine-dependent subjects is related to prefrontal and frontal cortical dysfunction and that dysfunction in these brain areas may underlie some aspects of cocaine addiction. In subjects with attention-deficit hyperactivity disorder and other psychiatric disorders, the Intra-Individual Reaction Time Variability (IIRTV) has been associated with frontal cortical dysfunction. In the pre...
International Nuclear Information System (INIS)
We review the recent progress in our understanding of the effect of B-site randomness on Pb(In1/2Nb1/2)O3 (PIN) from the experimental and theoretical viewpoints. PIN is one of the ideal systems for investigating the effect of perovskite B-site randomness on relaxor formation, because it can be in the antiferroelectric (AFE), ferroelectric (FE), or relaxor state depending on B-site randomness. Lattice dynamics measured in ordered and disordered PINs indicates the existence of FE instability regardless of the B-site randomness of PIN. AFE is stabilized when the B-site is spatially ordered, overwhelming FE instability. The hidden FE state starts to appear as B-site randomness becomes stronger and suppresses AFE instability. Ultimately, the randomness competes with the development of FE regions and blocks long-range FE ordering, which yields polar nanoregions (PNRs) resulting in relaxor behavior. In order to investigate the interesting behavior of PIN, we constructed a minimal model that includes dipolar interaction and easy-axis anisotropy which depends on B-site randomness. The results from Monte Carlo simulations show that the model well reproduces the phase diagram and dielectric constant of PIN qualitatively. (author)
Wang, Sheng-Dong; Zhou, Yong-Wu; Wang, Jun-Ping
2010-10-01
This article discusses production and order as well as advertising coordination issues in a single-manufacturer single-buyer supply chain, where the manufacturer sells a newsvendor-type product through the buyer who faces a random demand depending on advertising expenditure and selling price. The buyer has two ordering opportunities: the one happens before the beginning of the season, and the other takes place at the end of the season. The ordered items are produced by the manufacturer in two production modes for different requirements. The first production mode is relatively cheap but requires a long lead-time, whereas the second is expensive but offers quick response. Under such a setting, the centralised and decentralised decision models are developed, respectively, and the closed form solution to each model is provided as well. Moreover, we point out that the traditional revenue-sharing contract fails to coordinate the supply chain. We thus propose an improved revenue-sharing contract that requests the manufacturer not only shares the buyer's revenue but also bears a portion of the buyer's operating costs. Such a contract can achieve perfect coordination of the supply chain and arbitrarily allocate its profit between two parties.
Sarkar, Sanat K.
1998-01-01
Some new probability inequalities involving the ordered components of an $MTP_2$ random vector are derived, which provide an analytical proof of an important conjecture in the field of multiple hypothesis testing. This conjecture has been mostly validated so far using simulation.
Field Dependence-Independence as a Variable in Second Language Cloze Test Performance.
Hansen, Jacqueline; Stansfield, Charles
This paper explores the influence of field independent-dependent cognitive style on second language test performance, especially as it relates to performance on the integrative type of measure known as the cloze test. Approximately 250 college students enrolled in a first semester Spanish course formed the sample group for this correlational…
Sozcu, Omer Faruk
2014-01-01
This study examines the relationships between cognitive styles of field dependent learners with their attitudes towards e-learning (distance education) and instructional behavior in e-learning instruction. The Group Embedded Figures Test (GEFT) and the attitude survey (for students' preferences) towards e-learning instruction as distance…
Brown, J M; Stratmann, G; Cowley, D M; Mottram, B M; Chalmers, A H
1987-07-01
Twenty-two recurrent calcium stone formers had 24-h urinary oxalate excretions on their home diets which were significantly greater than those of 30 normal subjects (0.48 +/- 0.23 mmol/d; mean +/- SD compared with 0.31 +/- 0.11; P less than 0.01). The stone formers also demonstrated marked day to day variability in oxalate excretion indicating that a single normal urinary oxalate measurement did not exclude significant hyperoxaluria at other times. On a hospital diet containing 1000 mg calcium per day, urinary oxalate excretion fell significantly from 0.48 +/- 0.23 mmol/d to 0.32 +/- 0.12; P less than 0.01. As the urinary calcium excretion in and out of hospital was similar, it seems unlikely that low calcium intake at home was responsible for the hyperoxaluria. All patients had recurrent symptomatic stone disease and had been advised to avoid foods rich in oxalate. Whilst poor compliance is a possible explanation for the variability in oxalate excretion, we believe it is more likely that there is an inadvertent intake of oxalogenic precursors in their diet. As normal subjects do not demonstrate hyperoxaluria on similar home diets, stone formers may have a metabolic defect in the handling of these precursors. PMID:3662388
Rangwala, Imtiaz; Sinsky, Eric; Miller, James R.
2016-04-01
The future rate of climate change in mountains has many potential human impacts, including those related to water resources, ecosystem services, and recreation. Analysis of the ensemble mean response of CMIP5 global climate models (GCMs) shows amplified warming in high elevation regions during the cold season in boreal midlatitudes. We examine how the twenty-first century elevation-dependent response in the daily minimum surface air temperature [d(ΔTmin)/dz] varies among 27 different GCMs during winter for the RCP 8.5 emissions scenario. The focus is on regions within the northern hemisphere mid-latitude band between 27.5°N and 40°N, which includes both the Rocky Mountains and the Tibetan Plateau/Himalayas. We find significant variability in d(ΔTmin)/dz among the individual models ranging from 0.16 °C/km (10th percentile) to 0.97 °C/km (90th percentile), although nearly all of the GCMs (24 out of 27) show a significant positive value for d(ΔTmin)/dz. To identify some of the important drivers associated with the variability in d(ΔTmin)/dz during winter, we evaluate the co-variance between d(ΔTmin)/dz and the differential response of elevation-based anomalies in different climate variables as well as the GCMs' spatial resolution, their global climate sensitivity, and their elevation-dependent free air temperature response. We find that d(ΔTmin)/dz has the strongest correlation with elevation-dependent increases in surface water vapor, followed by elevation-dependent decreases in surface albedo, and a weak positive correlation with the GCMs' free air temperature response.
Boezen, H M; Postma, D S; Schouten, J P; Kerstjens, H A; Rijcken, B
1996-07-01
We investigated the coherence of bronchial hyperresponsiveness (BHR) and peak expiratory flow (PEF) variability in their relation to allergy markers and respiratory symptoms in 399 subjects (20-70 yr). Bronchial hyperresponsiveness to methacholine was defined by both the provocative dose causing a fall in FEV1 of 20%, and the dose-response slope. PEF variability was determined as diurnal PEF variation (amplitude percent mean) and between-day PEF variation. Skin tests positivity, serum total IgE, and specific IgE (RAST) for house-dust mite (HDM), cat, timothy grass, and birch ("pollen") were determined, as well as the number of peripheral blood eosinophils. Wheeze and nocturnal dyspnea were defined as asthma-like symptoms; dyspnea > or = grade 3, cough and phlegm as chronic obstructive pulmonary disease (COPD)-like symptoms. The reciprocal of the dose-response slope and PEF variability were significantly correlated (r = -0.39). Subjects with a positive skin test for HDM (odds ratio [OR] = 3.9), cat (OR = 8.3), or pollen (OR = 3.6), or specific IgE for HDM (OR = 2.3), cat (OR = 3.4), or pollen (OR = 1.9) had increased risk of BHR compared with the reference group (all p values blood eosinophils. There are different associations of BHR and PEF variability with allergy markers. Although BHR and PEF variability are significantly correlated, they cannot be used interchangeably in epidemiologic settings. PMID:8680695
Medyńska-Gulij, Beata; Cybulski, Paweł
2016-06-01
This paper analyses the use of table visual variables of statistical data of hospital beds as an important tool for revealing spatio-temporal dependencies. It is argued that some of conclusions from the data about public health and public expenditure on health have a spatio-temporal reference. Different from previous studies, this article adopts combination of cartographic pragmatics and spatial visualization with previous conclusions made in public health literature. While the significant conclusions about health care and economic factors has been highlighted in research papers, this article is the first to apply visual analysis to statistical table together with maps which is called previsualisation.
Directory of Open Access Journals (Sweden)
Medyńska-Gulij Beata
2016-06-01
Full Text Available This paper analyses the use of table visual variables of statistical data of hospital beds as an important tool for revealing spatio-temporal dependencies. It is argued that some of conclusions from the data about public health and public expenditure on health have a spatio-temporal reference. Different from previous studies, this article adopts combination of cartographic pragmatics and spatial visualization with previous conclusions made in public health literature. While the significant conclusions about health care and economic factors has been highlighted in research papers, this article is the first to apply visual analysis to statistical table together with maps which is called previsualisation.
Bucket-by-bucket on-axis/off-axis injection by fast kicker with variable position dependence of kick
International Nuclear Information System (INIS)
The bucket-by-bucket on-axis/off-axis injection system is proposed with new stripline fast kicker with variable position dependence of kick, from dipole to quadrupole, controlled by the drive voltage and its polarity. Applying the injection system to on-axis injection necessary for ultimate storage rings with narrow dynamic aperture, every bucket can be stored to achieve high average current with top-up operation. Also the minimum perturbation for stored beam can be achieved with the system by limiting the perturbations to injected bucket. Also the impurity electrons are prevented from injection with this system. (author)
Dependency of the Cusp Density Anomaly on the Variability of Forcing Inside and Outside the Cusp
Brinkman, D. G.; Walterscheid, R. L.; Clemmons, J. H.
2014-12-01
The Earth's magnetospheric cusp provides direct access of energetic particles to the thermosphere. These particles produce ionization and kinetic (particle) heating of the atmosphere. The increased ionization coupled with enhanced electric fields in the cusp produces increased Joule heating and ion drag forcing. These energy inputs largely determine the neutral density structure in the cusp region. Measurements by the CHAMP satellite (460-390- km altitude) have shown a region of strong enhanced density attributed to the combination of cusp particle and Joule heating. The Streak mission (325-123 km), on the other hand, observed a relative depletion in density in the cusp. While particle precipitation in the cusp is comparatively well constrained, the characteristics of the steady and fluctuating components of the electric field in the cusp are poorly constrained. Also, the significance of harder particle precipitation in areas adjacent to the cusp in particular at lower altitudes has not been addressed as it relates to the cusp density anomaly. We address the response of the cusp region to a range electrodynamical forcing with our high resolution two-dimensional time-dependent nonhydrostatic nonlinear dynamical model. We take advantage of our model's high resolution and focus on a more typical cusp width of 2 degrees in latitude. Earlier simulations have also shown a significant contribution from soft particle precipitation. We simulate the atmospheric response to a range of realizable magnitudes of the fluctuating and steady components of the electric field to examine the dependence of the magnitude of the cusp density anomaly on a large range of observed characteristics of the electrodynamical forcing and examine, in particular, the importance of particle heating relative to Joule heating. In addition we investigate the role of harder particle precipitation in areas adjacent to the cusp in determining the lower altitude cusp density and wind structure. We compare
ENERGY-DEPENDENT POWER SPECTRAL STATES AND ORIGIN OF APERIODIC VARIABILITY IN BLACK HOLE BINARIES
International Nuclear Information System (INIS)
We found that the black hole candidate MAXI J1659–152 showed distinct power spectra, i.e., power-law noise (PLN) versus band-limited noise (BLN) plus quasi-periodic oscillations (QPOs) below and above about 2 keV, respectively, in observations with Swift and the Rossi X-ray Timing Explorer during the 2010 outburst, indicating a high energy cutoff of the PLN and a low energy cutoff of the BLN and QPOs around 2 keV. The emergence of the PLN and the fading of the BLN and QPOs initially took place below 2 keV when the source entered the hard intermediate state and settled in the soft state three weeks later. The evolution was accompanied by the emergence of the disk spectral component and decreases in the amplitudes of variability in the soft and hard X-ray bands. Our results indicate that the PLN is associated with an optically thick disk in both hard and intermediate states, and the power spectral state is independent of the X-ray energy spectral state in a broadband view. We suggest that in the hard or intermediate state, the BLN and QPOs emerge from the innermost hot flow subjected to Comptonization, while the PLN originates from the optically thick disk farther out. The energy cutoffs of the PLN and the BLN or QPOs then follow the temperature of the seed photons from the inner edge of the optically thick disk, while the high frequency cutoff of the PLN follows the orbital frequency of the inner edge of the optically thick disk as well.
Seismic hazard from induced seismicity: effect of time-dependent hazard variables
Convertito, V.; Sharma, N.; Maercklin, N.; Emolo, A.; Zollo, A.
2012-12-01
Geothermal systems are drawing large attention worldwide as an alternative source of energy. Although geothermal energy is beneficial, field operations can produce induced seismicity whose effects can range from light and unfelt to severe damaging. In a recent paper by Convertito et al. (2012), we have investigated the effect of time-dependent seismicity parameters on seismic hazard from induced seismicity. The analysis considered the time-variation of the b-value of the Gutenberg-Richter relationship and the seismicity rate, and assumed a non-homogeneous Poisson model to solve the hazard integral. The procedure was tested in The Geysers geothermal area in Northern California where commercial exploitation has started in the 1960s. The analyzed dataset consists of earthquakes recorded during the period 2007 trough 2010 by the LBNL Geysers/Calpine network. To test the reliability of the analysis, we applied a simple forecasting procedure which compares the estimated hazard values in terms of ground-motion values having fixed probability of exceedance and the observed ground-motion values. The procedure is feasible for monitoring purposes and for calibrating the production/extraction rate to avoid adverse consequences. However, one of the main assumptions we made concern the fact that both median predictions and standard deviation of the ground-motion prediction equation (GMPE) are stationary. Particularly for geothermal areas where the number of recorded earthquakes can rapidly change with time, we want to investigate how a variation of the coefficients of the used GMPE and of the standard deviation influences the hazard estimates. Basically, we hypothesize that the physical-mechanical properties of a highly fractured medium which is continuously perturbed by field operations can produce variations of both source and medium properties that cannot be captured by a stationary GMPE. We assume a standard GMPE which accounts for the main effects which modify the scaling
Markowitz, A.; Turner, T. J.; Papadakis, I.; Arevalo, P.; Reeves, J. N.; Miller, L.
2007-01-01
We present the energy-dependent power spectral density (PSD) and cross-spectral properties of Mkn 766 obtained from a six-revolution XMM-Newton observation in 2005. The resulting PSDs, which have highest temporal frequency resolution for an AGN PSD to date, show breaks which increase in temporal frequency as photon energy increases; break frequencies differ by an average of approx.0.4 in the log between the softest and hardest bands. The consistency of the 2001 and 2005 observations variability properties, namely PSD shapes and the linear rms-flux relation, suggests the 2005 observation is simply a low-flux extension of the 2001 observation. The coherence function is measured to be approx.0.6-0.9 at temporal frequencies below the PSD break, and is lower for relatively larger energy band separation; coherence also drops significantly towards zero above the PSD break frequency. Temporal frequency-dependent soft-to-hard time lags are detected in this object for the first time: lags increase towards longer time scales and as energy separation increases. Cross-spectral properties are the thus consistent with previous measurements for Mkn 766 (Vaughan & Fabian 2003) and other accreting black hole systems. The results are discussed in the context of several variability models, including those based on inwardly-propagating viscosity variations in the accretion disk.
Directory of Open Access Journals (Sweden)
Peter M Wayne
2015-06-01
Full Text Available BACKGROUND: Tai Chi (TC exercise improves balance and reduces falls in older, health-impaired adults. TC’s impact on dual task (DT gait parameters predictive of falls, especially in healthy active older adults, however, is unknown.PURPOSE: To compare differences in usual and DT gait between long-term TC-expert practitioners and age-/gender-matched TC-naïve adults, and to determine the effects of short-term TC training on gait in healthy, non-sedentary older adults. METHODS: A cross-sectional study compared gait in healthy TC-naïve and TC-expert (24.5±12 yrs experience older adults. TC-naïve adults then completed a 6-month, two-arm, wait-list randomized clinical trial of TC training. Gait speed and stride time variability (% was assessed during 90 sec trials of undisturbed and cognitive DT (serial-subtractions conditions. RESULTS: During DT, gait speed decreased (p<0.003 and stride time variability increased (p<0.004 in all groups. Cross-sectional comparisons indicated that stride time variability was lower in the TC-expert vs. TC-naïve group, significantly so during DT (2.11% vs. 2.55%; p=0.027; in contrast, gait speed during both undisturbed and DT conditions did not differ between groups. Longitudinal analyses of TC-naïve adults randomized to 6 months of TC training or usual care identified improvement in DT gait speed in both groups. A small improvement in DT stride time variability (effect size = 0.2 was estimated with TC training, but no significant differences between groups were observed. Potentially important improvements after TC training could not be excluded in this small study. CONCLUSIONS: In healthy active older adults, positive effects of short- and long-term TC were observed only under cognitively challenging DT conditions and only for stride time variability. DT stride variability offers a potentially sensitive metric for monitoring TC’s impact on fall risk with healthy older adults.
International Nuclear Information System (INIS)
This paper deals with the role of platinum or titanium–titanium nitride electrodes on variability of resistive switching characteristics and electrical performances of HfO2-based memory elements. Capacitor-like Pt/HfO2 (10 nm)/Pt and Ti/HfO2 (10 nm)/TiN structures were fabricated on top of a tungsten pillar bottom electrode and integrated in-between two interconnect metal lines. First, quasi-static measurements were performed to apprehend the role of electrodes on electroforming, set and reset operations and their corresponding switching parameters. Memory elements with Pt as top and bottom electrodes exhibited a non-polar behavior with sharp decrease of current during reset operation while Ti/HfO2/TiN capacitors showed a bipolar switching behavior, with a gradual reset. In a second step, statistical distributions of switching parameters (voltage and resistance) were extracted from data obtained on few hundreds of capacitors. Even if the resistance in low resistive state and reset voltage was found to be comparable for both types of electrodes, the progressive reset operation observed on samples with Ti/TiN electrodes led to a lower variability of resistance in high resistive state and concomitantly of set voltage. In addition Ti–TiN electrodes enabled gaining: (i) lower forming and set voltages with significantly narrower capacitor-to-capacitor distributions; (ii) a better data retention capability (10 years at 65 °C instead of 10 years at 50 °C for Pt electrodes); (iii) satisfactory dynamic performances with lower set and reset voltages for ramp speed ranging from 10−2 to 107 V/s. The significant improvement of switching behavior with Ti–TiN electrodes is mainly attributed to the formation of a native interface layer between HfO2 oxide and Ti top electrode. - Highlights: ► HfO2 based capacitor-like structures were fabricated with Pt and Ti based electrodes. ► Influence of electrode materials on switching parameter variability is assessed.
Directory of Open Access Journals (Sweden)
Elibet Chávez González
2013-09-01
Full Text Available Introduction:The relationship between diastolic dysfunction and P-wave dispersion (PWD in the electrocardiogram has been studied for some time. In this regard, echocardiography is emerging as a diagnostic tool to improve risk stratification for mild hypertension.Objective:To determine the dependence of PWD on the electrocardiogram and on echocardiographic variables in a pediatric population.Methods: Five hundred and fifteen children from three elementary schools were studiedfrom a total of 565 children. Those whose parents did not want them to take part in the study, as well as those with known congenital diseases, were excluded. Tests including 12-lead surface ECGs and 4 blood pressure (BP measurements were performed. Maximum and minimum P-values were measured, and the PWD on the electrocardiogram was calculated. Echocardiography for structural measurements and the pulsed Doppler of mitral flow were also performed.Results: A significant correlation in statistical variables was found between PWD and mean BP for pre-hypertensive and hypertensive children, i.e., r= 0.32, p <0.01 and r= 0.33, p <0.01, respectively. There was a significant correlation found between PWD and the left atrial area (r= 0.45 and p <0.01.Conclusions: We highlight the dependency between PWD, the electrocardiogram and mean blood pressure. We also draw attention to the dependence of PWD on the left atrial area. This result provides an explanation for earlier changes in atrial electrophysiological and hemodynamic characteristics in pediatric patients.
International Nuclear Information System (INIS)
CHP (Combined heat and power) generation or cogeneration has been considered worldwide as the major alternative to traditional systems in terms of significant energy saving and environmental conservation. Furthermore, the wind power generators and photovoltaic units have vastly speared over the power systems due to their free inputs. However, there are many challenges for power system operators because of uncertain characteristics of renewable units and load demands. Therefore, a new multi-objective stochastic framework based on chance constrained programming is developed to handle combined heat and power economic load dispatch considering the stochastic characteristics of wind and photovoltaic power outputs, customer's electrical and heat load demands. The proposed technique makes use of a jointly distributed random variables method to calculate chance of meeting the electrical and heat load requirement using the target decision variables while maintaining the electrical energy cost below a scheduled value. The framework benefits from a new method named hybrid modified cuckoo search algorithm and differential evolution to extract the Pareto optimal surface for minimum cost and maximum probability of meeting the target cost and applies them as the objective functions. Applying to 6 and 40 unit test systems, the ability of the suggested framework is confirmed. - Highlights: • Formulate SMCHPED in a stochastic multi-objective framework based on CCP. • Use CCP with the concept of jointly distributed random variables method. • Coordinate the CHPs, TUs, WPGs and PVUs considering the existence uncertainties. • Propose a new powerful optimization algorithm based on combination of CSA and DE. • Find the Pareto optimal solutions for risk versus cost minimization
Institute of Scientific and Technical Information of China (English)
杨欢; 邹斌
2012-01-01
采用三阶多项式正态变换方法,将非正态相关的多维随机变量变换到正态不相关的变量空间,在正态不相关的变量空间中取采样点,最后将这些采样点通过逆变换重新变换到非正态相关的变量空间中进行潮流计算。这种变换—逆变换的过程使得点估计方法能够处理含非正态相关随机变量的概率潮流问题。利用该技术,提出了一种求解包含风力发电和负荷随机性的概率潮流问题的三点估计法。基于IEEE 118节点系统的算例分析表明,该方法具有较高的精度,且计算效率高,为讨论基于相关性的概率潮流问题提供了一种有效的工具。%The third-order polynomial normal transformation （TPNT） technique was employed to transform a multivariate non-normal dependent random variables group into a multivariate standard normal independent one. Sampling points were obtained in the standard normal independent variable space and transformed into multivariate non-normal dependent ones. Incorporating three-point estimate method with TPNT technique, a TPNT-based three-point estimate method is proposed to solve probabilistic power flow problems with non-normal dependent variables. A case study on a slightly modified IEEE 118-bus system shows that, the proposed method has high accuracy and computational efficiency. It is a qualified tool to discuss the probabilistic power flow problems with non-normal dependent variables.
International Nuclear Information System (INIS)
It is reported experimentally that low-threshold random lasing in a weakly scattering disordered structure formed by speckles using holography is achieved. It shows that the emission property of the structure is related directly to the pulse duration of the pump laser. If pumped by picosecond pulses, several spikes are observed in the emission. If pumped by a nanosecond laser, only a single dominant peak appears. The wavelength tunability of the random laser with a change in temperature has been demonstrated. The corresponding physical analyses have also been provided briefly.
El-Bary, Ahmed Abd; Aboelwafa, Ahmed A.; Al Sharabi, Ibrahim M.
2011-01-01
The aim of this work was to understand the influence of different formulation variables on the optimization of pH-dependent, colon-targeted, sustained-release mesalamine microspheres prepared by O/O emulsion solvent evaporation method, employing pH-dependent Eudragit S and hydrophobic pH-independent ethylcellulose polymers. Formulation variables studied included concentration of Eudragit S in the internal phase and the ratios between; internal to external phase, drug to Eudragit S and Eudragi...
Röken, Christian; Schöneberg, Sebastian; Schuppan, Florian
2016-01-01
A leptonic one-zone model accounting for the radiation emission of blazars is presented. This model describes multiple successive injections of mono-energetic, ultra-relativistic, interacting electron populations, which are subjected to synchrotron and synchrotron-self Compton radiative losses. The electron number density is computed analytically by solving a time-dependent, relativistic transport equation. Moreover, the synchrotron and synchrotron-self Compton intensities as well as the corresponding total fluences are explicitly calculated. The lightcurves and fluences are plotted for realistic parameter values, showing that the model can simultaneously explain both the specific short-time variability in the flaring of blazars and the characteristic broad-band fluence behavior.
Institute of Scientific and Technical Information of China (English)
Jeen-Hwa Wang
2009-01-01
The two one-state-variable, rate- and state-dependent friction laws, i.e., the slip and slowness laws, are compared on the basis of dynamical behavior of a one-degree-of-freedom spring-slider model through numerical simulations. Results show that two (normalized) model parameters, i.e., △(the normalized characteristic slip distance) and β-α (the difference in two normalized parameters of friction laws), control the solutions. From given values of △, β, and α, for the slowness laws, the solution exists and the unique non-zero fixed point is stable when △>(β-α), yet not when △<β-α). For the slip law, the solution exists for large ranges of model parameters and the number and stability of the non-zero fixed points change from one case to another. Results suggest that the slip law is more appropriate for controlling earthquake dynamics than the slowness law.
DEFF Research Database (Denmark)
Mikosch, Thomas Valentin; Moser, Martin
2013-01-01
We investigate the maximum increment of a random walk with heavy-tailed jump size distribution. Here heavy-tailedness is understood as regular variation of the finite-dimensional distributions. The jump sizes constitute a strictly stationary sequence. Using a continuous mapping argument acting on...
Using XMM-Newton to study the energy-dependent variability of H 1743-322 during its 2014 outburst
Stiele, H.; Yu, W.
2016-08-01
Black hole transients evolve during bright outbursts, showing distinct changes in their spectral and variability properties. These changes are interpreted as evidence for changes in the accretion flow and in the X-ray-emitting regions. We obtained an anticipated XMM-Newton Target of Opportunity observation of H 1743-322 during its outburst in 2014 September. Based on data from eight outbursts observed in the last 10 yr, we expected to catch the start of the hard-to-soft state transition. The fact that neither the general shape of the observed power density spectrum nor the characteristic frequency shows an energy dependence implies that the source remained in the low-hard state at the time of our observation near outburst peak. The spectral properties agree with the source being in the low-hard state, and a Swift/XRT monitoring of the outburst revealed that H 1743-322 stayed in the low-hard state during the entire outburst (known as a `failed outburst'). Here we derive the averaged QPO waveform and obtain phase-resolved spectra. A comparison of the phase-resolved spectra with the phase-averaged energy spectrum reveals spectral pivoting. We compare variability on long and short time-scales using covariance spectra and find that the covariance ratio does not show an increase towards lower energies. In other binaries an increase has been found. There are two possible explanations: either the absence of additional disc variability on longer time-scales is related to the high inclination of H 1743-322 compared with other black hole X-ray binaries, or it is the reason why we observe H 1743-322 during a failed outburst. More data on failed outbursts and on high-inclination sources will be needed in order to investigate these two possibilities further.
Directory of Open Access Journals (Sweden)
Ling Miao
2015-10-01
Full Text Available In this paper we study the effects of variable viscosity and thermal conductivity on the heat transfer in the pressure-driven fully developed flow of a slurry (suspension between two horizontal flat plates. The fluid is assumed to be described by a constitutive relation for a generalized second grade fluid where the shear viscosity is a function of the shear rate, temperature and concentration. The heat flux vector for the slurry is assumed to follow a generalized form of the Fourier’s equation where the thermal conductivity k depends on the temperature as well as the shear rate. We numerically solve the governing equations of motion in the non-dimensional form and perform a parametric study to see the effects of various dimensionless numbers on the velocity, volume fraction and temperature profiles. The different cases of shear thinning and thickening, and the effect of the exponent in the Reynolds viscosity model, for the temperature variation in viscosity, are also considered. The results indicate that the variable thermal conductivity can play an important role in controlling the temperature variation in the flow.
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Nicholas Baker Angstman
2015-02-01
Full Text Available In blast-related mild traumatic brain injury (br-mTBI little is known about the connections between initial trauma and expression of individual clinical symptoms. Partly due to limitations of current in vitro and in vivo models of br-mTBI, reliable prediction of individual short- and long-term symptoms based on known blast input has not yet been possible. Here we demonstrate a dose-dependent effect of shock wave exposure on C. elegans using shock waves that share physical characteristics with those hypothesized to induce br-mTBI in humans. Increased exposure to shock waves resulted in decreased mean speed of movement while increasing the proportion of worms rendered paralyzed. Recovery of these two behavioral symptoms was observed during increasing post-traumatic waiting periods. Although effects were observed on a population-wide basis, large interindividual variability was present between organisms exposed to the same highly controlled conditions. Reduction of cavitation by exposing worms to shock waves in polyvinyl alcohol resulted in reduced effect, implicating primary blast effects as damaging components in shock wave induced trauma. Growing worms on NGM agar plates led to the same general results in initial shock wave effect in a standard medium, namely dose-dependence and high interindividual variability, as raising worms in liquid cultures. Taken together, these data indicate that reliable prediction of individual clinical symptoms based on known blast input as well as drawing conclusions on blast input from individual clinical symptoms is not feasible in br-mTBI.
Konstenius, Maija; Jayaram-Lindström, Nitya; Guterstam, Joar; Beck, Olof; Philips, Björn; Franck, Johan
2014-01-01
AIM: To test the efficacy and safety of osmotic release oral system (OROS) methylphenidate (MPH) in doses up to 180 mg/day to treat attention deficit hyperactivity disorder (ADHD) and prevent any drug relapse in individuals with a co-diagnosis of ADHD and amphetamine dependence. DESIGN: Randomized placebo-controlled 24-week double-blind trial with parallel groups design. SETTING: Participants were recruited from medium security prisons in Sweden. The medication started within 2 weeks before r...
Randomized random walk on a random walk
International Nuclear Information System (INIS)
This paper discusses generalizations of the model introduced by Kehr and Kunter of the random walk of a particle on a one-dimensional chain which in turn has been constructed by a random walk procedure. The superimposed random walk is randomised in time according to the occurrences of a stochastic point process. The probability of finding the particle in a particular position at a certain instant is obtained explicitly in the transform domain. It is found that the asymptotic behaviour for large time of the mean-square displacement of the particle depends critically on the assumed structure of the basic random walk, giving a diffusion-like term for an asymmetric walk or a square root law if the walk is symmetric. Many results are obtained in closed form for the Poisson process case, and these agree with those given previously by Kehr and Kunter. (author)
DEFF Research Database (Denmark)
Asmussen, J.C.; Ibrahim, S.R.; Brincker, Rune
Abstraet Thispaper demansirates how to use the Random Decrement (RD) technique for identification o flinear structures subjected to ambient excitation. The theory behind the technique will be presented and guidelines how to choose the different variables will be given. This is done by introducing a...
DEFF Research Database (Denmark)
Asmussen, J. C.; Ibrahim, S. R.; Brincker, Rune
This paper demonstrates how to use the Random Decrement (RD) technique for identification of linear structures subjected to ambient excitation. The theory behind the technique will be presented and guidelines how to choose the different variables will be given. This is done by introducing a new...
DEFF Research Database (Denmark)
Asmussen, J. C.; Ibrahim, R.; Brincker, Rune
1998-01-01
This paper demonstrates how to use the Random Decrement (RD) technique for identification of linear structures subjected to ambient excitation. The theory behind the technique will be presented and guidelines how to choose the different variables will be given. This is done by introducing a new...
Directory of Open Access Journals (Sweden)
Nuria eRuffini
2015-08-01
Full Text Available Context: Heart Rate Variability (HRV indicates how heart rate changes in response to inner and external stimuli. HRV is linked to health status and it is an indirect marker of the autonomic nervous system (ANS function. Objective: To investigate the influence of osteopathic manipulative treatment (OMT on ANS activity through changes of High Frequency, a heart rate variability index indicating the parasympathetic activity, in healthy subjects, compared with sham therapy and control group.Methods: Sixty-six healthy subjects, both male and female, were included in the present 3-armed randomized placebo controlled within subject cross-over single blinded study. Participants were asymptomatic adults, both smokers and non-smokers and not on medications. At enrollment subjects were randomized in 3 groups: A, B, C. Standardized structural evaluation followed by a patient need-based osteopathic treatment was performed in the first session of group A and in the second session of group B. Standardized evaluation followed by a protocoled sham treatment was provided in the second session of group A and in the first session of group B. No intervention was performed in the two sessions of group C, acting as a time-control. The trial was registered on clinicaltrials.gov identifier: NCT01908920.Main Outcomes Measures: HRV was calculated from electrocardiography before, during and after the intervention, for a total amount time of 25 minutes.Results: OMT engendered a statistically significant increase of parasympathetic activity, as shown by High Frequency rate (p<0.001, and decrease of sympathetic activity, as revealed by Low Frequency rate (p<0.01; results also showed a reduction of Low Frequency/High Frequency ratio (p<0.001 and Detrended fluctuation scaling exponent (p<0.05. Conclusions: Findings suggested that OMT can influence ANS activity increasing parasympathetic function and decreasing sympathetic activity, compared to sham therapy and control group.
Variability Measures of Positive Random Variables
Czech Academy of Sciences Publication Activity Database
Košťál, Lubomír; Lánský, Petr; Pokora, Ondřej
2011-01-01
Roč. 6, č. 7 (2011), e21998. E-ISSN 1932-6203 R&D Projects: GA MŠk(CZ) LC554; GA ČR(CZ) GAP103/11/0282 Institutional research plan: CEZ:AV0Z50110509 Keywords : interspike interval * coefficient of variation * entropy * Fisher information Subject RIV: FH - Neurology Impact factor: 4.092, year: 2011
Institute of Scientific and Technical Information of China (English)
杨金英
2011-01-01
将实随机变量的条件独立性与条件回归独立性的研究推广到复随机变量,讨论了复随机变量的条件独立性、条件回归独立性及强条件独立的关系,得到了三者等价的几个充分必要条件.%This will be implemented conditional independence of random variables and conditions regressive independence extended to complex random variables, conditional independence of complex random variables, conditional regressive independence between strong conditional independence of relations is discussed,and several necessary and sufficient conditions are presented.
Using XMM-Newton to study the energy dependent variability of H 1743-322 during its 2014 outburst
Stiele, H
2016-01-01
Black hole transients during bright outbursts show distinct changes of their spectral and variability properties as they evolve during an outburst, that are interpreted as evidence for changes in the accretion flow and X-ray emitting regions. We obtained an anticipated XMM-Newton ToO observation of H 1743-322 during its outburst in September 2014. Based on data of eight outbursts observed in the last 10 years we expected to catch the start of the hard-to-soft state transition. The fact that neither the general shape of the observed power density spectrum nor the characteristic frequency show an energy dependence implies that the source still stays in the low-hard state at the time of our observation near outburst peak. The spectral properties agree with the source being in the low-hard state and a Swift/XRT monitoring of the outburst reveals that H 1743-322 stays in the low-hard state during the entire outburst (a. k. a. 'failed outburst'). We derive the averaged QPO waveform and obtain phase-resolved spectra...
Boufadel, Michel C.; Suidan, Makram T.; Venosa, Albert D.
1999-04-01
We present a formulation for water flow and solute transport in two-dimensional variably saturated media that accounts for the effects of the solute on water density and viscosity. The governing equations are cast in a dimensionless form that depends on six dimensionless groups of parameters. These equations are discretized in space using the Galerkin finite element formulation and integrated in time using the backward Euler scheme with mass lumping. The modified Picard method is used to linearize the water flow equation. The resulting numerical model, the MARUN model, is verified by comparison to published numerical results. It is then used to investigate beach hydraulics at seawater concentration (about 30 g l -1) in the context of nutrients delivery for bioremediation of oil spills on beaches. Numerical simulations that we conducted in a rectangular section of a hypothetical beach revealed that buoyancy in the unsaturated zone is significant in soils that are fine textured, with low anisotropy ratio, and/or exhibiting low physical dispersion. In such situations, application of dissolved nutrients to a contaminated beach in a freshwater solution is superior to their application in a seawater solution. Concentration-engendered viscosity effects were negligible with respect to concentration-engendered density effects for the cases that we considered.
International Nuclear Information System (INIS)
In ref. , a profound ansatz for modelling the various phenomena associated with the glass-transition was presented. It extends classical theories, such as the concept of fictive temperature or order parameters, for example, in two ways. Firstly, temperature excitations as well as mechanical loadings are accounted for in a single consistent approach. Secondly, it is not formulated in the θ-p-V space, but rather in the θ-T-E space, taking the tensor character of stress T and strain E into account. Hence, it is a three-dimensional theory where the basic thermodynamic potential, the Gibbs free energy, depends on the stress tensor, the temperature and a set of internal variables. In the current article, expressions for the enthalpy, the entropy, the thermal expansion and the specific heat are derived. The specific heat and the thermal expansion behaviour are looked at for various temperature excitations. It is shown, that the results are in accord with experimental observations in literature.
Institute of Scientific and Technical Information of China (English)
Fang-xiao Guan; Jing Wang; Ji-lin Pan; Qing Wang; Lei Zhua
2011-01-01
We studied cycle time (0.01-10 s with triangular input waves) and poling history (continuous versus fresh poling) dependent electric energy storage and discharge behaviors in poly(vinylidene fluoride-co-hexafluoropropylene) [P(VDFHFP)] films using the electric displacement — the electric field (D-E) hysteresis loop measurements. Since the permanent dipoles in PVDF are orientational in nature, it is generally considered that both charging and discharging processes should be time and poling history dependent. Intriguingly, our experimental results showed that the charging process depended heavily on the cycle time and the prior poling history, and thus the D-E hysteresis loops had different shapes accordingly. However, the discharged energy density did not change no matter how the D-E loop shape varied due to different measurements. This experimental result could be explained in terms of reversible and irreversible polarizations. The reversible polarization could be charged and discharged fairly quickly (＜ 5 ms for each process), while the irreversible polarization depended heavily on the poling time and the prior poling history. This study suggests that it is only meaningful to compare the discharged energy density for PVDF and its copolymer films when different cycle times and poling histories are used.
Muskens, O.L.; Beek, van der T.; Lagendijk, A.
2011-01-01
The frequency correlations of light in complex photonic media are of interest as a tool for characterizing the dynamical aspects of light diffusion. We demonstrate here that the frequency correlation shows a pronounced angle dependence both in transmission and in reflection geometries. Using a broad
Energy Technology Data Exchange (ETDEWEB)
Ivanov, D.A. [Ecole Polytechnique Federale de Lausanne (EPFL), Institute for Theoretical Physics, CH-1015 Lausanne (Switzerland); Skvortsov, M.A. [L.D. Landau Institute for Theoretical Physics, Moscow 119334 (Russian Federation)]. E-mail: skvor@itp.ac.ru
2006-03-13
We analyze the perturbative series of the Keldysh-type sigma-model proposed recently for describing the quantum mechanics with time-dependent Hamiltonians from the unitary Wigner-Dyson random-matrix ensemble. We observe that vertices of orders higher than four cancel, which allows us to reduce the calculation of the energy-diffusion constant to that in a special kind of the matrix {phi}{sup 4} model. We further verify that the perturbative four-loop correction to the energy-diffusion constant in the high-velocity limit cancels, in agreement with the conjecture of one of the authors.
Operant Variability: Some Random Thoughts
Marr, M. Jackson
2012-01-01
Barba's (2012) paper is a serious and thoughtful analysis of a vexing problem in behavior analysis: Just what should count as an operant class and how do people know? The slippery issue of a "generalized operant" or functional response class illustrates one aspect of this problem, and "variation" or "novelty" as an operant appears to fall into…
Uniform estimate for maximum of randomly weighted sums with applications to insurance risk theory
Institute of Scientific and Technical Information of China (English)
WANG; Dingcheng; SU; Chun
2005-01-01
This paper obtains the uniform estimate for maximum of sums of independent and heavy-tailed random variables with nonnegative random weights, which can be arbitrarily dependent of each other. Then the applications to ruin probabilities in a discrete time risk model with dependent stochastic returns are considered.
Indian Academy of Sciences (India)
Gopal K Basak; Arunangshu Biswas
2013-02-01
In this paper we show that the continuous version of the self-normalized process $Y_{n,p}(t)=S_n(t)/V_{n,p}+(nt-[nt])X_{[nt]+1}/V_{n,p},0 < t ≤ 1;p>0$ where $S_n(t)=\\sum^{[nt]}_{i=1}X_i$ and $V_{(n,p)}=\\left(\\sum^n_{i=1}|X_i|^p\\right)^{1/p}$ and $X_i i.i.d.$ random variables belong to $DA()$, has a non-trivial distribution $\\mathrm{iff}$ ==2. The case for 2>> and ≤ < 2 is systematically eliminated by showing that either of tightness or finite dimensional convergence to a non-degenerate limiting distribution does not hold. This work is an extension of the work by Csörgő et al. who showed Donsker’s theorem for $Y_{n,2}(\\cdot p)$, i.e., for $p=2$, holds $\\mathrm{iff}$ =2 and identified the limiting process as a standard Brownian motion in sup norm.
Azam, Muhammad Abid; Katz, Joel; Fashler, Samantha R; Changoor, Tina; Azargive, Saam; Ritvo, Paul
2015-10-01
Heart rate variability (HRV) is a vagal nerve-mediated biomarker of cardiac function used to investigate chronic illness, psychopathology, stress and, more recently, attention-regulation processes such as meditation. This study investigated HRV in relation to maladaptive perfectionism, a stress-related personality factor, and mindfulness meditation, a stress coping practice expected to elevate HRV, and thereby promote relaxation. Maladaptive perfectionists (n=21) and Controls (n=39) were exposed to a lab-based assessment in which HRV was measured during (1) a 5-minute baseline resting phase, (2) a 5-minute cognitive stress-induction phase, and (3) a post-stress phase. In the post-stress phase, participants were randomly assigned to a 10-minute audio-instructed mindfulness meditation condition or a 10-minute rest condition with audio-description of mindfulness meditation. Analyses revealed a significant elevation in HRV during meditation for Controls but not for Perfectionists. These results suggest that mindfulness meditation promotes relaxation following cognitive stress and that the perfectionist personality hinders relaxation possibly because of decreased cardiac vagal tone. The results are discussed in the context of developing psychophysiological models to advance therapeutic interventions for distressed populations. PMID:26116778
DEFF Research Database (Denmark)
Bogh, Morten K B; Schmedes, Anne V; Philipsen, Peter A;
2011-01-01
Ultraviolet-B (UV-B) radiation increases serum vitamin D level expressed as 25-hydroxyvitamin D(3) (25(OH)D), but the dose-response relationship and the importance of dose rate is unclear. Of 172 fair-skinned persons screened for 25(OH)D, 55 with insufficient baseline 25(OH)D=50 nm (mean 31.2 nm...... exposed. Skin pigmentation and 25(OH)D were measured before and after the irradiations. The increase in 25(OH)D after UV-B exposure (adjusted for baseline 25(OH)D) was positively correlated with the UV-B dose (P=0.001; R(2) =0.176) but not to dose rate (1-20 min). 25(OH)D increased in response to four UV......) were selected and randomized to one of 11 groups of five participants. Each group was exposed to one of four different UV-B doses: 0.375, 0.75, 1.5 or 3.0 standard erythema dose (SED) for 1, 5, 10 or 20 min. All participants had four UV-B sessions with 2- to 3-day interval with 24% of their skin...
Directory of Open Access Journals (Sweden)
Karn Wijarnpreecha
Full Text Available Iron-overload cardiomyopathy is a major cause of death in thalassemia patients due to the lack of an early detection strategy. Although cardiac magnetic resonance (CMR T2* is used for early detection of cardiac iron accumulation, its availability is limited. Heart rate variability (HRV has been used to evaluate cardiac autonomic function and found to be depressed in thalassemia. However, its direct correlation with cardiac iron accumulation has never been investigated. We investigated whether HRV can be used as an alternative indicator for early identification of cardiac iron deposition in thalassemia patients.Ninety-nine non-transfusion dependent thalassemia patients (23.00 (17.00, 32.75 years, 35 male were enrolled. The correlation between HRV recorded using 24-hour Holter monitoring and non-transferrin bound iron (NTBI, hemoglobin (Hb, serum ferritin, LV ejection fraction (LVEF, and CMR-T2* were determined.The median NTBI value was 3.15 (1.11, 6.59 μM. Both time and frequency domains of HRV showed a significant correlation with the NTBI level, supporting HRV as a marker of iron overload. Moreover, the LF/HF ratio showed a significant correlation with CMR-T2* with the receiver operating characteristic (ROC curve of 0.684±0.063, suggesting that it could represent the cardiac iron deposit in thalassemia patients. HRV was also significantly correlated with serum ferritin and Hb.This novel finding regarding the correlation between HRV and CMR-T2* indicates that HRV could be a potential marker in identifying early cardiac iron deposition prior to the development of LV dysfunction, and may be used as an alternative to CMR-T2* for screening cardiac iron status in thalassemia patients.
Meyer, Nele; Welp, Gerhard; Amelung, Wulf
2016-04-01
Climate change is suspected to alter temperature, soil moisture, and nutrient inputs to the soil. These factors are supposed to strongly influence soil respiration. The degree by which respiration will respond to these changes is crucial for assessing future CO2 feedbacks to the atmosphere. We assume that the temperature sensitivity of soil respiration (Q10) differs spatially depending on land use, soil unit, and texture owing to their diverse properties of soil organic matter quantity and quality. We further hypothesize that the Q10 value is additionally regulated by soil moisture and nutrient status. On the basis of soil and land use maps we divided the Rur catchment (Western Germany, 2350 km²) into so called environmental soil classes (ESC) that combine each a unique combination of the factors land use, soil unit, and texture. We took nine samples from each of the 12 most common ESC's and incubated them at five temperatures (5-25°C), at four soil moisture levels (30-75% water holding capacity), and with an unfertilized and a fertilized treatment. So far, our results indicate that both soil respiration and the Q10 value are spatially highly variable with Q10 values ranging from 1 to 4. The Q10 value is altered by the level of soil moisture and decreases when soils are as moist as 75% water holding capacity. Fertilization has no effect on the Q10 value. Currently, we are processing the whole data-set to derive the effect of ESC's on the Q10 value. Recent data suggest that forest soils are more sensitive to warming than cropland soils.
Directory of Open Access Journals (Sweden)
Milan Kubiatko
2014-11-01
Full Text Available Attitude is a dual-poled essence: possessing positive thoughts on a course or subject, liking a course or exhibiting positive affective nature in relation with it, or having negative thoughts on a course or subject, disliking it or exhibiting negative affective features in relation with it (Bloom, 1979. Attitudes are different from opinions, values and beliefs. Attitudes and opinions resemble each other, but they differ from attitudes in terms of degree of generalizability and the measuring technique. Opinions are personal reactions to specific occurrences and conditions. But attitudes should be taken in a more general sense, as they influence people's reactions against sets of events and groups of people, in a more broad sense. The teaching profession has been mentioned among the favorite occupations, and researchers wanted to know if attitudes have anything to do with this tendency. It has been a subject for many researches that attitudes towards teaching profession differ by gender (Cook & Medley, 1954; Capri & Celikkaleli, 2008; Cetin, 2003; Dogan & Coban, 2009. The aim of this research is to determine the impact of gender variable on the teaching profession via meta-analysis method. Effect models specified for meta-analysis have been compared. This research covers the results of meta-analysis combining 27 researches determined useful by master's theses and doctorate dissertations which take gender as the variable. Effect size of the gender in relation with the attitude towards the teaching profession is found to be 0.301 for the fixed effect model, and 0.304 for the random effect model. When a frequency table for directions of effect sizes is created, 20 researches (74% showed a positive effect size. Together with this result, 74% of the researches explain that females have more positive attitudes over males. Absence of any 0 effect size in this research explain that there has been no research indicating that attitudes towards the teaching
Wang, Sijian; Nan, Bin; Rosset, Saharon; Zhu, Ji
2011-03-01
We propose a computationally intensive method, the random lasso method, for variable selection in linear models. The method consists of two major steps. In step 1, the lasso method is applied to many bootstrap samples, each using a set of randomly selected covariates. A measure of importance is yielded from this step for each covariate. In step 2, a similar procedure to the first step is implemented with the exception that for each bootstrap sample, a subset of covariates is randomly selected with unequal selection probabilities determined by the covariates' importance. Adaptive lasso may be used in the second step with weights determined by the importance measures. The final set of covariates and their coefficients are determined by averaging bootstrap results obtained from step 2. The proposed method alleviates some of the limitations of lasso, elastic-net and related methods noted especially in the context of microarray data analysis: it tends to remove highly correlated variables altogether or select them all, and maintains maximal flexibility in estimating their coefficients, particularly with different signs; the number of selected variables is no longer limited by the sample size; and the resulting prediction accuracy is competitive or superior compared to the alternatives. We illustrate the proposed method by extensive simulation studies. The proposed method is also applied to a Glioblastoma microarray data analysis. PMID:22997542
van Goor, H; Stuiver, B
1998-01-01
Due to a lack of pertinent data, little is known about nonresponse in substantive, generally "dependent" variables and its consequences. However, in a study on policy performance of Dutch municipalities, we were fortunately able to gather performance data fur respondents and nonrespondents from inde
Kayri, Murat; Gunuc, Selim
2010-01-01
Internet dependency is going to expand into social life in wide area whereas it has been accepted as a pathological and psychological disease. Knowing the basic effects of internet dependency is an inevitable approach to use the internet technology healthy. In this study, internet dependency levels of 754 students were examined with the Internet…
Directory of Open Access Journals (Sweden)
Coll-de-Tuero Gabriel
2012-08-01
Full Text Available Abstract Background Kidney disease is associated with an increased total mortality and cardiovascular morbimortality in the general population and in patients with Type 2 diabetes. The aim of this study is to determine the prevalence of kidney disease and different types of renal disease in patients with type 2 diabetes (T2DM. Methods Cross-sectional study in a random sample of 2,642 T2DM patients cared for in primary care during 2007. Studied variables: demographic and clinical characteristics, pharmacological treatments and T2DM complications (diabetic foot, retinopathy, coronary heart disease and stroke. Variables of renal function were defined as follows: 1 Microalbuminuria: albumin excretion rate & 30 mg/g or 3.5 mg/mmol, 2 Macroalbuminuria: albumin excretion rate & 300 mg/g or 35 mg/mmol, 3 Kidney disease (KD: glomerular filtration rate according to Modification of Diet in Renal Disease 2 and/or the presence of albuminuria, 4 Renal impairment (RI: glomerular filtration rate 2, 5 Nonalbuminuric RI: glomerular filtration rate 2 without albuminuria and, 5 Diabetic nephropathy (DN: macroalbuminuria or microalbuminuria plus diabetic retinopathy. Results The prevalence of different types of renal disease in patients was: 34.1% KD, 22.9% RI, 19.5% albuminuria and 16.4% diabetic nephropathy (DN. The prevalence of albuminuria without RI (13.5% and nonalbuminuric RI (14.7% was similar. After adjusting per age, BMI, cholesterol, blood pressure and macrovascular disease, RI was significantly associated with the female gender (OR 2.20; CI 95% 1.86–2.59, microvascular disease (OR 2.14; CI 95% 1.8–2.54 and insulin treatment (OR 1.82; CI 95% 1.39–2.38, and inversely associated with HbA1c (OR 0.85 for every 1% increase; CI 95% 0.80–0.91. Albuminuria without RI was inversely associated with the female gender (OR 0.27; CI 95% 0.21–0.35, duration of diabetes (OR 0.94 per year; CI 95% 0.91–0.97 and directly associated with HbA1c (OR 1.19 for every
Steland, Ansgar
2012-01-01
To detect changes in the mean of a time series, one may use previsible detection procedures based on nonparametric kernel prediction smoothers which cover various classic detection statistics as special cases. Bandwidth selection, particularly in a data-adaptive way, is a serious issue and not well studied for detection problems. To ensure data adaptation, we select the bandwidth by cross-validation, but in a sequential way leading to a functional estimation approach. This article provides the asymptotic theory for the method under fairly weak assumptions on the dependence structure of the error terms, which cover, e.g., GARCH($p,q$) processes, by establishing (sequential) functional central limit theorems for the cross-validation objective function and the associated bandwidth selector. It turns out that the proof can be based in a neat way on \\cite{KurtzProtter1996}'s results on the weak convergence of \\ito integrals and a diagonal argument. Our gradual change-point model covers multiple change-points in th...
Random effects coefficient of determination for mixed and meta-analysis models
Demidenko, Eugene; Sargent, James; Onega, Tracy
2012-01-01
The key feature of a mixed model is the presence of random effects. We have developed a coefficient, called the random effects coefficient of determination, Rr2, that estimates the proportion of the conditional variance of the dependent variable explained by random effects. This coefficient takes values from 0 to 1 and indicates how strong the random effects are. The difference from the earlier suggested fixed effects coefficient of determination is emphasized. If Rr2 is close to 0, t...
Lin, D; Böttcher, M; Liang, E P
1999-01-01
Using the data from the Rossi X-ray Timing Explorer (RXTE), we report the different energy dependence of the variability of the four persistent hard X-ray sources in the low-hard state: Cygnus X-1, GX 339-4, GRS 1758-258 and 1E 1740.7-2942. Cygnus X-1 is found to have a flatter power density spectrum (PDS) shape at higher energies. The other three sources have energy independent PDS shapes. The energy dependence of the overall variability (the integrated rms amplitude) varies from source to source and from observation to observation. 1E~1740.7-2942, for example, has a variability generally increasing with energy while GX 339-4 has a decreasing variability. A general trend is found in the four sources that the integrated rms amplitude anti-correlates with the X-ray flux. We compare these distinct energy dependent behaviors with several emission models. None of the models can fully explain all the features that we have found.
Time dependence of the UV resonance lines in the cataclysmic variables SU UMa, RX And and 0623+71
International Nuclear Information System (INIS)
We present IUE observations of the dwarf novae SU UMa and RX And, and of the nova-like variable 0623 + 71. At the time of observation, SU UMa and RX And were in outburst. All three systems show variability in the wind-formed UV resonance lines of N v λ 1240, Si IV λ 1397 and C IV λ 1549 on timescale of hours. The amplitude of variation is smallest in RX And and largest in 0623 + 71. There is evidence that the variations observed in SU UMa's UV spectrum repeat on the orbital period. Our observations of SU UMa also reveal variability in the continuum flux during the decline from outburst maximum that is much more marked in the UV than at optical wavelengths. (author)
Directory of Open Access Journals (Sweden)
Brissette Suzanne
2011-07-01
Full Text Available Abstract Background Substitution with opioid-agonists (e.g., methadone has shown to be an effective treatment for chronic long-term opioid dependency. Patient satisfaction with treatment has been associated with improved addiction treatment outcomes. However, there is a paucity of studies evaluating patients' satisfaction with Opioid Substitution Treatment (OST. In the present study, participants' satisfaction with OST was evaluated at 3 and 12 months. We sought to test the relationship between satisfaction and patients' characteristics, the treatment modality received and treatment outcomes. Methods Data from a randomized controlled trial, the North American Opiate Medication Initiative (NAOMI, conducted in Vancouver and Montreal (Canada between 2005-2008, was analyzed. The NAOMI study compared the effectiveness of oral methadone vs. injectable diacetylmorphine over 12 months. A small sub-group of patients received injectable hydromorphone on a double blind basis with diacetylmorphine. The Client Satisfaction Questionnaire (CSQ-8 was used to measure satisfaction with treatment. CSQ-8 scores, as well as retention and response to treatment, did not differ between those receiving hydromorphone and diacetylmorphine at 3 or 12 months assessments; therefore, these two groups were analyzed together as the 'injectable' treatment group. Results A total of 232 (92% and 237 (94% participants completed the CSQ-8 at 3 and 12 months, respectively. Participants in both groups were highly satisfied with treatment. Independent of treatment group, participants satisfied with treatment at 3 months were more likely to be retained at 12 months. Multivariate analysis indicated that satisfaction was greater among those randomized to the injection group after controlling for treatment effectiveness. Participants who were retained, responded to treatment, and had fewer psychological symptoms were more satisfied with treatment. Finally, open-ended comments were made by
Institute of Scientific and Technical Information of China (English)
谭成良; 吴群英; 何燕梅
2011-01-01
In this paper, we establish a Rosenthal-type inequality of partial sums for ρ--mixing random variables. As its applications, we get the complete convergence rates in the strong laws for ρ--mixing random variables. The result obtained extends the corresponding result.
History-Dependent Random Discounting
Higashi, Youichiro; Hyogo, Kazuya; Takeoka, Norio
2009-09-01
In the literature of dynamic models under uncertainty, it is commonly assumed that uncertainty is resolved gradually over time and its resolution is independent of the actions taken by a decision maker up to that time period. However, contingencies in the decision maker's mind may change and even increase over time according to habits that have evolved by experiences, actions, or consumptions in the past. We provide an axiomatic model where the decision maker faces uncertainty about her own time preference or discount factors in future and these uncertainty may evolve according to histories or habits from the past consumption.
Institute of Scientific and Technical Information of China (English)
李思齐; 李昌兴; 柳晓燕
2011-01-01
二维连续型随机变量函数的密度函数的计算既是概率论教学中的一个重点,又是一个难点.本文介绍了一般二维连续型随机变量函数的分布密度的计算方法,并给出了一个新的方法——密度函数转化法.%Calculation of distribution density function of two-dimensional continuous random variable is one of the important and difficult points in probability theory teaching. The present paper first introduces some common methods for calculating the distribution density function of two-dimensional continuous random variable, and then a new approach--transform of density function is proposed.
Kissling, Grace E.; Dertinger, Stephen; Hayashi, Makoto; MacGregor, James T.
2007-01-01
Until recently, the in vivo erythrocyte micronucleus assay has been scored using microscopy. Because the frequency of micronucleated cells is typically low, cell counts are subject to substantial binomial counting error. Counting error, along with inter-animal variability, limit the sensitivity of this assay. Recently, flow cytometric methods have been developed for scoring micronucleated erythrocytes and these methods enable many more cells to be evaluated than is possible with microscopic s...
Two-Stage Modelling Of Random Phenomena
Barańska, Anna
2015-12-01
The main objective of this publication was to present a two-stage algorithm of modelling random phenomena, based on multidimensional function modelling, on the example of modelling the real estate market for the purpose of real estate valuation and estimation of model parameters of foundations vertical displacements. The first stage of the presented algorithm includes a selection of a suitable form of the function model. In the classical algorithms, based on function modelling, prediction of the dependent variable is its value obtained directly from the model. The better the model reflects a relationship between the independent variables and their effect on the dependent variable, the more reliable is the model value. In this paper, an algorithm has been proposed which comprises adjustment of the value obtained from the model with a random correction determined from the residuals of the model for these cases which, in a separate analysis, were considered to be the most similar to the object for which we want to model the dependent variable. The effect of applying the developed quantitative procedures for calculating the corrections and qualitative methods to assess the similarity on the final outcome of the prediction and its accuracy, was examined by statistical methods, mainly using appropriate parametric tests of significance. The idea of the presented algorithm has been designed so as to approximate the value of the dependent variable of the studied phenomenon to its value in reality and, at the same time, to have it "smoothed out" by a well fitted modelling function.
Institute of Scientific and Technical Information of China (English)
李金秋
2012-01-01
Considering the importance of uniform distribution and the higher-order moment of sum of random variables, the higher-order moment of sum of i. i. d U( 0,1) random variables is computed by multinomial theorem and Stirling number of the second kind in combinatorics. The computational formula is got Base on this formula and binomial theorem, the formula of the higher-moment of sum of i. i. d I/(a,b) random variables is got. At last, some examples are given.%考虑到均匀分布与随机变量和的高阶矩的重要性,利用组合数学中的多项式定理和第二类Stirling数对独立同U(0,1)随机变量和的高阶矩进行了计算,得到了相应的计算公式.并以此为基础利用二项式定理,得到了独立同U(a,b)随机变量和的高阶矩的计算公式.最后给出了计算实例.
Savić R.; Petrović M.; Radojković D.; Radović Č.; Parunović N.; Pušić M.; Radišić R.
2013-01-01
The main objective of this study was to evaluate the effect of age (A) and the intensity of the boars' utilization (s) on the phenotypic variability of ejaculate volume (VOL) and sperm motility (MO). The study included 274 ejaculates of Large White boars (LW). Boars were divided into six classes according the age when the ejaculate was taken (10-13, 14-17, 18-21, 22-25, 26-29 and ≥30 months). Semen samples were analyzed during four seasons (spring, summer, ...
Griffin, Leslie Little
The purpose of this study was to determine the relationship of selected cognitive abilities and physical science misconceptions held by preservice elementary teachers. The cognitive abilities under investigation were: formal reasoning ability as measured by the Lawson Classroom Test of Formal Reasoning (Lawson, 1978); working memory capacity as measured by the Figural Intersection Test (Burtis & Pascual-Leone, 1974); verbal intelligence as measured by the Acorn National Academic Aptitude Test: Verbal Intelligence (Kobal, Wrightstone, & Kunze, 1944); and field dependence/independence as measured by the Group Embedded Figures Test (Witkin, Oltman, & Raskin, 1971). The number of physical science misconceptions held by preservice elementary teachers was measured by the Misconceptions in Science Questionnaire (Franklin, 1992). The data utilized in this investigation were obtained from 36 preservice elementary teachers enrolled in two sections of a science methods course at a small regional university in the southeastern United States. Multiple regression techniques were used to analyze the collected data. The following conclusions were reached following an analysis of the data. The variables of formal reasoning ability and verbal intelligence were identified as having significant relationships, both individually and in combination, to the dependent variable of selected physical science misconceptions. Though the correlations were not high enough to yield strong predictors of physical science misconceptions or strong relationships, they were of sufficient magnitude to warrant further investigation. It is recommended that further investigation be conducted replicating this study with a larger sample size. In addition, experimental research should be implemented to explore the relationships suggested in this study between the cognitive variables of formal reasoning ability and verbal intelligence and the dependent variable of selected physical science misconceptions
Directory of Open Access Journals (Sweden)
Tamara Tosic
2016-01-01
Full Text Available For decades, research in neuroscience has supported the hypothesis that brain dynamics exhibits recurrent metastable states connected by transients, which together encode fundamental neural information processing. To understand the system’s dynamics it is important to detect such recurrence domains, but it is challenging to extract them from experimental neuroscience datasets due to the large trial-to-trial variability. The proposed methodology extracts recurrent metastable states in univariate time series by transforming datasets into their time-frequency representations and computing recurrence plots based on instantaneous spectral power values in various frequency bands. Additionally, a new statistical inference analysis compares different trial recurrence plots with corresponding surrogates to obtain statistically significant recurrent structures. This combination of methods is validated by applying it to two artificial datasets. In a final study of visually-evoked Local Field Potentials in partially anesthetized ferrets, the methodology is able to reveal recurrence structures of neural responses with trial-to-trial variability. Focusing on different frequency bands, the delta-band activity is much less recurrent than alpha-band activity. Moreover, alpha-activity is susceptible to pre-stimuli, while delta-activity is much less sensitive to pre-stimuli. This difference in recurrence structures in different frequency bands indicates diverse underlying information processing steps in the brain.
Michaelides, Michalis P.; Haertel, Edward H.
2014-01-01
The standard error of equating quantifies the variability in the estimation of an equating function. Because common items for deriving equated scores are treated as fixed, the only source of variability typically considered arises from the estimation of common-item parameters from responses of samples of examinees. Use of alternative, equally…
El Hachimi, A. G.; Dakir, O.; Sidi Ahmed, S.; Zaari, H.; El Yadari, M.; Benyoussef, A.; El Kenz, A.
2016-09-01
The effect of random crystal-field on the stationary states of the kinetic spin-3/2 Blume-Capel model is investigated within the framework of the mean-field approach. The Glauber-type stochastic dynamics is used to describe the time evolution of the system which is subject to a time-dependent oscillating external magnetic field. In addition to the well-known phase transitions and the appearance of the partly ferromagnetic phase characterized by the magnetization m = 1 in equilibrium case, a new dynamical regions between the ferromagnetic phases F1/2, F1 and F3/2 are found where F3/2 +F 1 / 2 ,F3/2 +F1, F1 +F1/2 phases coexist for a weak value of the reduced magnetic field (h). Whereas for higher value of h both solutions ordered F and disordered P phases coexist. Hence we present six types topologies of phase diagrams which exhibit dynamical first-order, second-order transition lines, dynamical tricritical and isolated critical end points. Furthermore, the dynamical thermal behavior magnetizations, susceptibilities and phase space trajectories are given and discussed.
Yang, Xian-Qing; Zhang, Wei; Qiu, Kang; Xu, Wen-tao; Tang, Gang; Ren, Lin
2007-10-01
In this paper we numerically study the probability Pac of the occurrence of traffic accidents in the Nagel-Schreckenberg (NS) model with velocity-dependent randomization (VDR). Numerical results show that there is a critical density over which car accidents occur, but below which no car accidents happen. Different from the accident probability in the NS model, the accident probability in the VDR model monotonously decreases with increase of car density above the critical density. The value of the accident probability is only determined by the stochastic noise and the number of cars on road. In the stochastic VDR model with the speed limit vmax=1, no critical density exists and car accidents happen in the whole density region. The braking probabilities of standing cars and moving cars have different influences on the accident probability. A mean-field theory reveals that the accident probability is proportional to the mean density of “go and stop” wave per time step. Theoretical analyses give excellent agreement with numerical results in the VDR model.
Phase Transition in Unrestricted Random SAT
Schuh, Bernd R
2012-01-01
For random CNF formulae with m clauses, n variables and an unrestricted number of literals per clause the transition from high to low satisfiability can be determined exactly for large n. The critical density m/n turns out to be strongly n-dependent, ccr = ln(2)/(1-p)^^n, where pn is the mean number of positive literals per clause.This is in contrast to restricted random SAT problems (random K-SAT), where the critical ratio m/n is a constant. All transition lines are calculated by the second moment method applied to the number of solutions N of a formula. In contrast to random K-SAT, the method does not fail for the unrestricted model, because long range interactions between solutions are not cut off by disorder.
Institute of Scientific and Technical Information of China (English)
王琳; 刘保东
2013-01-01
The random variable fuzzy recognition model was established for the coexistence of randomness and fuzziness in cleaner production assessment. A random term obeying normal distribution was introduced to the variable fuzzy recognition model, so the randomness and fuzziness could be studied simultaneously. Four random fuzzy recognition submodels were generated by controlling the distance parameter p and the optimization parameter a, and then according to the 3σ principle of normal distribution, after choosing a reasonable confidence, the grade was identified by the confidence interval of grade feature value. Compared with the scoring model of centesimal system, this model could cut down the effect of subjective preference on assessment results, and could improve the maneuverability and accuracy in evaluation process. The experimental results showed that the random variable fuzzy recognition model could evaluate the cleaner production level accurately, which could also provide a reference for cleaner production assessment.%针对清洁生产评价中模糊性与随机性并存的问题,建立随机可变模糊识别模型.向可变模糊识别模型中引入一个服从正态分布的随机项,同步研究模糊性和随机性.通过控制模型中距离参数p和优化准则参数α,得到4个随机模糊识别子模型,随后根据正态分布3σ原则,选择合理的置信度,得到级别特征值的置信区间,以此判断隶属级别.该模型与传统百分制评分模型相比削减了主观偏好对评价结果的影响,提高了评价的可操作性和准确性.实例结果证明随机可变模糊识别模型能准确评价清洁生产水平,为清洁生产评价工作提供参考.
Schein, ASO; Correa, APS; Casali, Karina Rabello; Schaan, Beatriz D.
2016-01-01
Background Physical exercise reduces glucose levels and glucose variability in patients with type 2 diabetes. Acute inspiratory muscle exercise has been shown to reduce these parameters in a small group of patients with type 2 diabetes, but these results have yet to be confirmed in a well-designed study. The aim of this study is to investigate the effect of acute inspiratory muscle exercise on glucose levels, glucose variability, and cardiovascular autonomic function in patients with type 2 d...
Valenza, Gaetano; Nardelli, Mimma; Lanatà, Antonio; Gentili, Claudio; Bertschy, Gilles; Paradiso, Rita; Scilingo, Enzo Pasquale
2014-09-01
Current clinical practice in diagnosing patients affected by psychiatric disorders such as bipolar disorder is based only on verbal interviews and scores from specific questionnaires, and no reliable and objective psycho-physiological markers are taken into account. In this paper, we propose to use a wearable system based on a comfortable t-shirt with integrated fabric electrodes and sensors able to acquire electrocardiogram, respirogram, and body posture information in order to detect a pattern of objective physiological parameters to support diagnosis. Moreover, we implemented a novel ad hoc methodology of advanced biosignal processing able to effectively recognize four possible clinical mood states in bipolar patients (i.e., depression, mixed state, hypomania, and euthymia) continuously monitored up to 18 h, using heart rate variability information exclusively. Mood assessment is intended as an intrasubject evaluation in which the patient's states are modeled as a Markov chain, i.e., in the time domain, each mood state refers to the previous one. As validation, eight bipolar patients were monitored collecting and analyzing more than 400 h of autonomic and cardiovascular activity. Experimental results demonstrate that our novel concept of personalized and pervasive monitoring constitutes a viable and robust clinical decision support system for bipolar disorders recognizing mood states with a total classification accuracy up to 95.81%. PMID:24240031
Edgington, Eugene
2007-01-01
Statistical Tests That Do Not Require Random Sampling Randomization Tests Numerical Examples Randomization Tests and Nonrandom Samples The Prevalence of Nonrandom Samples in Experiments The Irrelevance of Random Samples for the Typical Experiment Generalizing from Nonrandom Samples Intelligibility Respect for the Validity of Randomization Tests Versatility Practicality Precursors of Randomization Tests Other Applications of Permutation Tests Questions and Exercises Notes References Randomized Experiments Unique Benefits of Experiments Experimentation without Mani
A Kendall correlation coefficient for functional dependence
Valencia García, Dalia Jazmín; Romo, Juan; Lillo, Rosa E.
2013-01-01
Measuring dependence is a basic question when dealing with functional observations. The usual correlation for curves is not robust. Kendall's coefficient is a natural description of dependence between finite dimensional random variables. We extend this concept to functional observations. Given a bivariate sample of functions, a robust analysis of dependence can be carried out through the functional version of a Kendall correlation coefficient introduced in this paper. We also study its statis...
Park, Seong-Beom; Lee, Inah
2016-08-01
Place cells in the hippocampus fire at specific positions in space, and distal cues in the environment play critical roles in determining the spatial firing patterns of place cells. Many studies have shown that place fields are influenced by distal cues in foraging animals. However, it is largely unknown whether distal-cue-dependent changes in place fields appear in different ways in a memory task if distal cues bear direct significance to achieving goals. We investigated this possibility in this study. Rats were trained to choose different spatial positions in a radial arm in association with distal cue configurations formed by visual cue sets attached to movable curtains around the apparatus. The animals were initially trained to associate readily discernible distal cue configurations (0° vs. 80° angular separation between distal cue sets) with different food-well positions and then later experienced ambiguous cue configurations (14° and 66°) intermixed with the original cue configurations. Rats showed no difficulty in transferring the associated memory formed for the original cue configurations when similar cue configurations were presented. Place field positions remained at the same locations across different cue configurations, whereas stability and coherence of spatial firing patterns were significantly disrupted when ambiguous cue configurations were introduced. Furthermore, the spatial representation was extended backward and skewed more negatively at the population level when processing ambiguous cue configurations, compared with when processing the original cue configurations only. This effect was more salient for large cue-separation conditions than for small cue-separation conditions. No significant rate remapping was observed across distal cue configurations. These findings suggest that place cells in the hippocampus dynamically change their detailed firing characteristics in response to a modified cue environment and that some of the firing
Directory of Open Access Journals (Sweden)
Girón Sandra
2011-02-01
Full Text Available Abstract Background Many studies have suggested a relationship between metabolic abnormalities and impaired fetal growth with the development of non-transmissible chronic diseases in the adulthood. Moreover, it has been proposed that maternal factors such as endothelial function and oxidative stress are key mechanisms of both fetal metabolic alterations and subsequent development of non-transmissible chronic diseases. The objective of this project is to evaluate the effect of micronutrient supplementation and regular aerobic exercise on endothelium-dependent vasodilation maternal and stress oxidative of the newborn. Methods and design 320 pregnant women attending to usual prenatal care in Cali, Colombia will be included in a factorial randomized controlled trial. Women will be assigned to the following intervention groups: 1. Control group: usual prenatal care (PC and placebo (maltodextrine. 2. Exercise group: PC, placebo and aerobic physical exercise. 3. Micronutrients group: PC and a micronutrients capsule consisting of zinc (30 mg, selenium (70 μg, vitamin A (400 μg, alphatocopherol (30 mg, vitamin C (200 mg, and niacin (100 mg. 4. Combined interventions Group: PC, supplementation of micronutrients, and aerobic physical exercise. Anthropometric measures will be taken at the start and at the end of the interventions. Discussion Since in previous studies has been showed that the maternal endothelial function and oxidative stress are related to oxidative stress of the newborn, this study proposes that complementation with micronutrients during pregnancy and/or regular physical exercise can be an early and innovative alternative to strengthen the prevention of chronic diseases in the population. Trial registration NCT00872365.
Sigmund, Eric E.; Novikov, Dmitry S.; Sui, Dabang; Ukpebor, Obehi; Baete, Steven; Babb, James S.; Liu, Kecheng; Feiweier, Thorsten; Kwon, Jane; Mcgorty, KellyAnne; Bencardino, Jenny; Fieremans, Els
2014-01-01
Purpose To collect diffusion tensor imaging (DTI) at multiple diffusion times Td in skeletal muscle in normal subjects and chronic exertional compartment syndrome (CECS) patients and analyze the data with the random permeable barrier model (RPBM) for biophysical specificity. Materials and Methods Using an IRB-approved HIPAA-compliant protocol, seven patients with clinical suspicion of CECS and eight healthy volunteers underwent DTI of the calf muscle in a Siemens MAGNETOM Verio 3-T scanner at rest and after treadmill exertion at 4 different diffusion times. Radial diffusion values λrad were computed for each of 7 different muscle compartments and analyzed with RPBM to produce estimates of free diffusivity D0, fiber diameter a, and permeability κ. Fiber diameter estimates were compared with measurements from literature autopsy reference for several compartments. Response factors (post/pre-exercise ratios) were computed and compared between normal controls and CECS patients using a mixed-model two-way analysis of variance. Results All subjects and muscle compartments showed nearly time-independent diffusion along and strongly time-dependent diffusion transverse to the muscle fibers. RPBM estimates of fiber diameter correlated well with corresponding autopsy reference. D0 showed significant (pmeasurements combined with appropriate tissue modeling can provide enhanced microstructural specificity for in vivo tissue characterization. In CECS patients, our results suggest that high-pressure interfiber edema elevates free diffusion and restricts exercise-induced fiber dilation. Such specificity may be useful in differentiating CECS from other disorders or in predicting its response to either physical therapy or fasciotomy. PMID:24610770
Energy Technology Data Exchange (ETDEWEB)
Hoffman, A. J.; Lee, J. C. [Department of Nuclear Engineering and Radiological Sciences, University of Michigan, 2355 Bonisteel Boulevard, Ann Arbor, MI, 48109-2104 (United States)
2013-07-01
A new time-dependent neutron transport method based on the method of characteristics (MOC) has been developed. Whereas most spatial kinetics methods treat time dependence through temporal discretization, this new method treats time dependence by defining the characteristics to span space and time. In this implementation regions are defined in space-time where the thickness of the region in time fulfills an analogous role to the time step in discretized methods. The time dependence of the local source is approximated using a truncated Taylor series expansion with high order derivatives approximated using backward differences, permitting the solution of the resulting space-time characteristic equation. To avoid a drastic increase in computational expense and memory requirements due to solving many discrete characteristics in the space-time planes, the temporal variation of the boundary source is similarly approximated. This allows the characteristics in the space-time plane to be represented analytically rather than discretely, resulting in an algorithm comparable in implementation and expense to one that arises from conventional time integration techniques. Furthermore, by defining the boundary flux time derivative in terms of the preceding local source time derivative and boundary flux time derivative, the need to store angularly-dependent data is avoided without approximating the angular dependence of the angular flux time derivative. The accuracy of this method is assessed through implementation in the neutron transport code DeCART. The method is employed with variable-order local source representation to model a TWIGL transient. The results demonstrate that this method is accurate and more efficient than the discretized method. (authors)
International Nuclear Information System (INIS)
A new time-dependent neutron transport method based on the method of characteristics (MOC) has been developed. Whereas most spatial kinetics methods treat time dependence through temporal discretization, this new method treats time dependence by defining the characteristics to span space and time. In this implementation regions are defined in space-time where the thickness of the region in time fulfills an analogous role to the time step in discretized methods. The time dependence of the local source is approximated using a truncated Taylor series expansion with high order derivatives approximated using backward differences, permitting the solution of the resulting space-time characteristic equation. To avoid a drastic increase in computational expense and memory requirements due to solving many discrete characteristics in the space-time planes, the temporal variation of the boundary source is similarly approximated. This allows the characteristics in the space-time plane to be represented analytically rather than discretely, resulting in an algorithm comparable in implementation and expense to one that arises from conventional time integration techniques. Furthermore, by defining the boundary flux time derivative in terms of the preceding local source time derivative and boundary flux time derivative, the need to store angularly-dependent data is avoided without approximating the angular dependence of the angular flux time derivative. The accuracy of this method is assessed through implementation in the neutron transport code DeCART. The method is employed with variable-order local source representation to model a TWIGL transient. The results demonstrate that this method is accurate and more efficient than the discretized method. (authors)
Multivariate Tests for Correlated Data in Completely Randomized Designs.
Mielke, Paul W., Jr.; Berry, Kenneth J.
1999-01-01
Provides power comparisons for three permutation tests and the Bartlett-Nanda-Pillai trace test (BNP) (M. Bartlett, 1939; D. Nanda, 1950; K. Pillai, 1955) in completely randomized experimental designs with correlated multivariate-dependent variables. The power of the BNP was generally found to be less than that of at least one of the permutation…
Palacios, C.; Abecia, J. A.
2015-05-01
A total number of 48,088 artificial inseminations (AIs) have been controlled during seven consecutive years in 79 dairy sheep Spanish farms (41° N). Mean, maximum and minimum ambient temperatures ( Ts), temperature amplitude (TA), mean relative humidity (RH), mean solar radiation (SR) and total rainfall of each insemination day and 15 days later were recorded. Temperature-humidity index (THI) and effective temperature (ET) have been calculated. A binary logistic regression model to estimate the risk of not getting pregnant compared to getting pregnant, through the odds ratio (OR), was performed. Successful winter inseminations were carried out under higher SR ( P inseminations under lower SR values ( P inseminations during the summer were performed under significantly lower maximum T ( P inseminations resulted in pregnancy when they were carried out under higher maximum ( P 1 (maximum T, ET and rainfall on AI day, and ET and rainfall on day 15), and two variables presented OR <1 (SR on AI day and maximum T on day 15). However, the effect of meteorological factors affected fertility in opposite ways, so T becomes a protective or risk factor on fertility depending on season. In conclusion, the percentage of pregnancy after AI in sheep is significantly affected by meteorological variables in a seasonal-dependent manner, so the parameters such as temperature reverse their effects in the hot or cold seasons. A forecast of the meteorological conditions could be a useful tool when AI dates are being scheduled.
Fischer, Andreas; Liniger, Mark; Appenzeller, Christof
2014-05-01
The new climate change scenarios "CH2011" provide a consistent assessment of how precipitation and temperature may change in Switzerland during the 21st century. Digital data were made available at different spatial and temporal aggregation levels. Here we revisit one product of CH2011, the climate scenarios of seasonal means, with the aim to enhance its practicalities for impcat studies. These scenarios are based on the joint analysis of several regional climate models (RCMs) from the ENSEMBLES project that were all run according to the A1B emission scenario. Combined multi-model projections using a sophisticated Bayesian algorithm are provided for three different Swiss regions, four seasons and three projection periods in the 21st century. Uncertainty, arising from model-to-model projection and from internal decadal variability, is expressed with three estimates following an expert judgement: a lower, medium and upper estimate. In CH2011, the three uncertainty estimates are derived and provided in an univariate way separately for each lead-time, region and season without providing information on combined changes and uncertainties. Yet, for impact applications often several climatological variables must be considered together and across all four seasons. Here, we elucidate further on the inter-seasonal and inter-variable dependencies by inspecting correlations in the underlying climate model data of CH2011. The analysis shows that a firm conclusion on the correlation structure is highly challenged by the uncertainty of the different model projections, by the limited set of independent models and, possibly, the complex climate regime Switzerland is located in. Regarding the inter-variable relationship toward the end of the 21st century, confidence is still too low to make firm conclusions, although in summer a tendency for a negative relation can be inferred from the limited model set. Similar to the inter-variable relation, no recommendation can be given on how to
Nishimura, Rimei; Tanaka, Yuko; Koiwai, Kazuki; Inoue, Kohei; Hach, Thomas; Salsali, Afshin; Lund, Søren S; Broedl, Uli C.
2015-01-01
Background This study evaluated the effect of empagliflozin on postprandial glucose (PPG) and 24-hour glucose variability in Japanese patients with type 2 diabetes mellitus (T2DM). Methods Patients (N = 60; baseline mean [SD] HbA1c 7.91 [0.80]%; body mass index 24.3 [3.2] kg/m2) were randomized to receive empagliflozin 10 mg (n = 20), empagliflozin 25 mg (n = 19) or placebo (n = 21) once daily as monotherapy for 28 days. A meal tolerance test and continuous glucose monitoring (CGM) for 24 hou...
Operational Risk Aggregation Based on Business Line Dependence: A Mutual Information Approach
Wenzhou Wang; Limeng Shi; Xiaoqian Zhu
2016-01-01
The dependencies between different business lines of banks have serious effects on the accuracy of operational risk estimation. Furthermore, the dependencies are far more complicated than simple linear correlation. While Pearson correlation coefficient is constructed based on the hypothesis of a linear association, the mutual information that measures all the information of a random variable contained in another random variable is a powerful alternative. Based on mutual information, the gener...
DEFF Research Database (Denmark)
Moeller, Niels C; Korsholm, Lars; Kristensen, Peter L;
2008-01-01
, the primary aim of this study was to calculate and apply unit-specific calibration factors in multiple accelerometers in order to examine the impact on random output variation caused by inter-instrument variability. METHODS: Instrument-specific calibration factors were estimated in 25 MTI- and 53 CSA...... during free living conditions. RESULTS: Calibration reduced inter-instrument variability considerably in the mechanical setup, both in the MTI instruments (raw SDbetween units = 195 counts*min-1 vs. calibrated SDbetween units = 65 counts*min-1) and in the CSA instruments (raw SDbetween units = 343 counts.......3% vs. CVcalibrated = 35.7%). High correlations (r = 0.99 & r = 0.98, respectively) were observed between raw and calibrated field data, and the proportion of the total variation caused by the MTI- and CSA monitor was estimated to be only 1.1% and 4.2%, respectively. Compared to the CSA instruments, a...
Identification and shape restrictions in nonparametric instrumental variables estimation
Freyberger, Joachim; Horowitz, Joel
2012-01-01
This paper is concerned with inference about an unidentified linear function, L(g), where the function g satisfies the relation Y=g(X)+U; E(U |W)=0. In this relation, Y is the dependent variable, X is a possibly endogenous explanatory variable, W is an instrument for X and U is an unobserved random variable. The data are an independent random sample of (Y, X, W). In much applied research, X and W are discrete, and W has fewer points of support than X. Consequently, neither g nor L(g) is nonpa...
Soichiro Kaneko; Masashi Watanabe; Shin Takayama; Takehiro Numata; Takashi Seki; Junichi Tanaka; Seiki Kanemura; Yutaka Kagaya; Tadashi Ishii; Yoshitaka Kimura; Nobuo Yaegashi
2013-01-01
Objective. We investigated the relationship between superior mesenteric artery blood flow volume (SMA BFV) and autonomic nerve activity in acupuncture stimulation of lower limb points through heart rate variability (HRV) evaluations. Methods. Twenty-six healthy volunteers underwent crossover applications of bilateral manual acupuncture stimulation at ST36 or LR3 or no stimulation. Heart rate, blood pressure, cardiac index, systemic vascular resistance index, SMA BFV, and HRV at rest and 30 mi...
Directory of Open Access Journals (Sweden)
Rosemann Thomas
2011-04-01
Full Text Available Abstract Background The purpose of this study was to investigate the effect of short-term supplementation of amino acids before and during a 100 km ultra-marathon on variables of skeletal muscle damage and muscle soreness. We hypothesized that the supplementation of amino acids before and during an ultra-marathon would lead to a reduction in the variables of skeletal muscle damage, a decrease in muscle soreness and an improved performance. Methods Twenty-eight experienced male ultra-runners were divided into two groups, one with amino acid supplementation and the other as a control group. The amino acid group was supplemented a total of 52.5 g of an amino acid concentrate before and during the 100 km ultra-marathon. Pre- and post-race, creatine kinase, urea and myoglobin were determined. At the same time, the athletes were asked for subjective feelings of muscle soreness. Results Race time was not different between the groups when controlled for personal best time in a 100 km ultra-marathon. The increases in creatine kinase, urea and myoglobin were not different in both groups. Subjective feelings of skeletal muscle soreness were not different between the groups. Conclusions We concluded that short-term supplementation of amino acids before and during a 100 km ultra-marathon had no effect on variables of skeletal muscle damage and muscle soreness.
The partial copula: Properties and associated dependence measures
Spanhel, Fabian; Kurz, Malte S.
2015-01-01
The partial correlation coefficient is a commonly used measure to assess the conditional dependence between two random variables. We provide a thorough explanation of the partial copula, which is a natural generalization of the partial correlation coefficient, and investigate several of its properties. In addition, properties of some associated partial dependence measures are examined.
Institute of Scientific and Technical Information of China (English)
Jianping Chu; Xueli Shen; Jun Fan; Changhai Chen; Shuyang Lin
2008-01-01
BACKGROUND: Heart rate variability refers to the beat-to-beat alteration in heart rate. It is usually a slight periodic variation of R-R intervals. Much information of autonomic nerve system balance can be obtained by measuring the heart rate variability of patients. It remains to be shown whether heart rate variability can be used as an index for determining the severity of insomnia and cerebral infarction. OBJECTIVE: This study aimed to analyze the correlation for each frequency spectrum parameter of heart rate variability with an insomnia index, as well as the degree of neurological defects in patients with simple cerebral infarction and cerebral infarction complicated by insomnia. The goal was to verify the feasibility of frequency spectrum parameters for heart rate variability as a marker for insomnia and cerebral infarction. DESIGN: A case-control observation. SETTING: Department of Neurology, First Hospital Affiliated to China Medical University. PARTICIPANTS: Sixty inpatients, and/or outpatients, with cerebral infarction were admitted to the 202 Hospital of Chinese PLA between December 2005 and October 2006, confirmed by CT, and recruited to the study. According to the insomnia condition (insomnia is defined by a Pittsburgh Sleep Quality Index score > 7), the patients were assigned to a simple cerebral infarction group and a cerebral infarction complicated by insomnia group, with 30 subjects in each group. Thirty additional subjects, who concurrently received ex-aminations and were confirmed to not suffer from cerebral infarction and insomnia, were recruited into the control group. Written informed consent was obtained from each subject for laboratory specimens. The pro-tocol was approved by the Hospital's Ethics Committee. METHODS: Following admission, each subject's neurological impairment was assessed with the National Institutes of Health Stroke Scale and Pittsburgh Sleep Quality Index. Heart rate variability of each subject was measured with an
Limit theorems for Markov random fields
International Nuclear Information System (INIS)
Markov Random Fields (MRF's) have been extensively applied in Statistical Mechanics as well as in Bayesian Image Analysis. MRF's are a special class of dependent random variables located at the vertices of a graph whose joint distribution includes a parameter called the temperature. When the number of vertices of the graph tends to infinity, the normalized distribution of statistics based on these random variables converge in distribution. It can happen that for certain values of the temperature, that the rate of growth of these normalizing constants change drastically. This feature is generally used to explain the phenomenon of phase transition as understood by physicist. In this dissertation the author will show that this drastic change in normalizing constants occurs even in the relatively smooth case when all the random variables are Gaussian. Hence any image analytic MRF ought to be checked for such discontinuous behavior before any analysis is performed. Mixed limit theorems in Bayesian Image Analysis seek to replace intensive simulations of MRF's with limit theorems that approximate the distribution of the MRF's as the number of sites increases. The problem of deriving mixed limit theorems for MRF's on a one dimensional lattice graph with an acceptor function that has a second moment has been studied by Chow. A mixed limit theorem for the integer lattice graph is derived when the acceptor function does not have a second moment as for instance when the acceptor function is a symmetric stable density of index 0 < α < 2
Directory of Open Access Journals (Sweden)
A. K. Bhunia
2011-04-01
Full Text Available In this paper, a single item deterministic inventory model with two separate warehouses called owned warehouse/show-room (OW and rented warehouse (RW is developed. The proposed model of this paper also considers a realistic assumption regarding the storage capacity of the rented warehouse. Demand is a function of selling price, advertisement of an item and displayed inventory level in OW. The stocks of RW are shipped to OW under bulk release pattern where shortages are not allowed. We discuss different scenarios of the proposed model to address relative size of stock dependency parameters and the capacity of owned warehouse. For each scenario, the corresponding problem is formulated as a constrained mixed integer nonlinear programming problem with three integer and two non-integer variables and a real coded genetic algorithm (RCGA is developed to solve the resulted problem. The proposed model of the paper is also examined using some numerical examples and sensitivity analysis is performed.
Energy Technology Data Exchange (ETDEWEB)
Cabout, T., E-mail: Thomas.Cabout@cea.fr [CEA LETI, MINATEC Campus, 17 Rue des Martyrs, 38054 Grenoble France (France); Buckley, J.; Cagli, C.; Jousseaume, V.; Nodin, J.-F.; Salvo, B. de [CEA LETI, MINATEC Campus, 17 Rue des Martyrs, 38054 Grenoble France (France); Bocquet, M.; Muller, Ch. [Im2np, UMR CNRS 7334, Aix-Marseille Université, 38 Rue Joliot Curie, 13451 Marseille Cedex 20 (France)
2013-04-30
This paper deals with the role of platinum or titanium–titanium nitride electrodes on variability of resistive switching characteristics and electrical performances of HfO{sub 2}-based memory elements. Capacitor-like Pt/HfO{sub 2} (10 nm)/Pt and Ti/HfO{sub 2} (10 nm)/TiN structures were fabricated on top of a tungsten pillar bottom electrode and integrated in-between two interconnect metal lines. First, quasi-static measurements were performed to apprehend the role of electrodes on electroforming, set and reset operations and their corresponding switching parameters. Memory elements with Pt as top and bottom electrodes exhibited a non-polar behavior with sharp decrease of current during reset operation while Ti/HfO{sub 2}/TiN capacitors showed a bipolar switching behavior, with a gradual reset. In a second step, statistical distributions of switching parameters (voltage and resistance) were extracted from data obtained on few hundreds of capacitors. Even if the resistance in low resistive state and reset voltage was found to be comparable for both types of electrodes, the progressive reset operation observed on samples with Ti/TiN electrodes led to a lower variability of resistance in high resistive state and concomitantly of set voltage. In addition Ti–TiN electrodes enabled gaining: (i) lower forming and set voltages with significantly narrower capacitor-to-capacitor distributions; (ii) a better data retention capability (10 years at 65 °C instead of 10 years at 50 °C for Pt electrodes); (iii) satisfactory dynamic performances with lower set and reset voltages for ramp speed ranging from 10{sup −2} to 10{sup 7} V/s. The significant improvement of switching behavior with Ti–TiN electrodes is mainly attributed to the formation of a native interface layer between HfO{sub 2} oxide and Ti top electrode. - Highlights: ► HfO2 based capacitor-like structures were fabricated with Pt and Ti based electrodes. ► Influence of electrode materials on switching
Directory of Open Access Journals (Sweden)
Glauco Avelino Sampaio Oliveira
2014-05-01
Full Text Available This article investigates how sectorial characteristics determine the probability of industries receiving an anti-dumping (AD duty, delving into the economic literature on the political economy of protection, market competition and trade reform in Brazil. By focusing on when the AD was granted, the article concentrates on the objective economic motivations for an industry to claim protection and which are instrumental to the decision of the trade defense authority. The empirical strategy involves a panel of 93 industrial sectors from 1996 to 2007 to create four groups of explanatory variables (collective action/competition, economic performance, factors of production, trade coefficients, reflecting their structural characteristics, market competition, economic performance and political mobilization. The econometric specifications apply binary dependent variable models (logit with cluster robust and population-averaged error correction. The results show that structure of trade (imports volume and tariffs, economic performance (productivity and investments, and factor content (labor and natural resources influence the probability of the AD. Political economy characteristics (captured by interactive terms are also influential in determining the measure.
Osborn, B.; Chapple, W.; Ewers, B. E.; Williams, D. G.
2014-12-01
The interaction between soil conditions and climate variability plays a central role in the ecohydrological functions of montane conifer forests. Although soil moisture availability to trees is largely dependent on climate, the depth and texture of soil exerts a key secondary influence. Multiple Pleistocene glacial events have shaped the landscape of the central Rocky Mountains creating a patchwork of soils differing in age and textural classification. This mosaic of soil conditions impacts hydrological properties, and montane conifer forests potentially respond to climate variability quite differently depending on the age of glacial till and soil development. We hypothesized that the age of glacial till and associated soil textural changes exert strong control on growth and photosynthetic gas exchange of lodgepole pine. We examined physiological and growth responses of lodgepole pine to interannual variation in maximum annual snow water equivalence (SWEmax) of montane snowpack and growing season air temperature (Tair) and vapor pressure deficit (VPD) across a chronosequence of Pleistocene glacial tills ranging in age from 700k to 12k years. Soil textural differences across the glacial tills illustrate the varying degrees of weathering with the most well developed soils with highest clay content on the oldest till surfaces. We show that sensitivity of growth and carbon isotope discrimination, an integrated measure of canopy gas exchange properties, to interannual variation SWEmax , Tair and VPD is greatest on young till surfaces, whereas trees on old glacial tills with well-developed soils are mostly insensitive to these interannual climate fluctuations. Tree-ring widths were most sensitive to changes in SWEmax on young glacial tills (p < 0.01), and less sensitive on the oldest till (p < 0.05). Tair correlates strongly with δ13C values on the oldest and youngest tills sites, but shows no significant relationship on the middle aged glacial till. It is clear that
Harvested populations are more variable only in more variable environments.
Cameron, Tom C; O'Sullivan, Daniel; Reynolds, Alan; Hicks, Joseph P; Piertney, Stuart B; Benton, Tim G
2016-06-01
The interaction between environmental variation and population dynamics is of major importance, particularly for managed and economically important species, and especially given contemporary changes in climate variability. Recent analyses of exploited animal populations contested whether exploitation or environmental variation has the greatest influence on the stability of population dynamics, with consequences for variation in yield and extinction risk. Theoretical studies however have shown that harvesting can increase or decrease population variability depending on environmental variation, and requested controlled empirical studies to test predictions. Here, we use an invertebrate model species in experimental microcosms to explore the interaction between selective harvesting and environmental variation in food availability in affecting the variability of stage-structured animal populations over 20 generations. In a constant food environment, harvesting adults had negligible impact on population variability or population size, but in the variable food environments, harvesting adults increased population variability and reduced its size. The impact of harvesting on population variability differed between proportional and threshold harvesting, between randomly and periodically varying environments, and at different points of the time series. Our study suggests that predicting the responses to selective harvesting is sensitive to the demographic structures and processes that emerge in environments with different patterns of environmental variation. PMID:27516873
Cooper, Colin; Frieze, Alan
The aim of this article is to discuss some of the notions and applications of random walks on finite graphs, especially as they apply to random graphs. In this section we give some basic definitions, in Section 2 we review applications of random walks in computer science, and in Section 3 we focus on walks in random graphs.
Moeller, Niels C; Korsholm, Lars; Kristensen, Peter L; Andersen, Lars B; Wedderkopp, Niels; Froberg, Karsten
2008-01-01
Background Potentially, unit-specific in-vitro calibration of accelerometers could increase field data quality and study power. However, reduced inter-unit variability would only be important if random instrument variability contributes considerably to the total variation in field data. Therefore, the primary aim of this study was to calculate and apply unit-specific calibration factors in multiple accelerometers in order to examine the impact on random output variation caused by inter-instrument variability. Methods Instrument-specific calibration factors were estimated in 25 MTI- and 53 CSA accelerometers in a mechanical setup using four different settings varying in frequencies and/or amplitudes. Calibration effect was analysed by comparing raw and calibrated data after applying unit-specific calibration factors to data obtained during quality checks in a mechanical setup and to data collected during free living conditions. Results Calibration reduced inter-instrument variability considerably in the mechanical setup, both in the MTI instruments (raw SDbetween units = 195 counts*min-1 vs. calibrated SDbetween units = 65 counts*min-1) and in the CSA instruments (raw SDbetween units = 343 counts*min-1 vs. calibrated SDbetween units = 67 counts*min-1). However, the effect of applying the derived calibration to children's and adolescents' free living physical activity data did not alter the coefficient of variation (CV) (children: CVraw = 30.2% vs. CVcalibrated = 30.4%, adolescents: CVraw = 36.3% vs. CVcalibrated = 35.7%). High correlations (r = 0.99 & r = 0.98, respectively) were observed between raw and calibrated field data, and the proportion of the total variation caused by the MTI- and CSA monitor was estimated to be only 1.1% and 4.2%, respectively. Compared to the CSA instruments, a significantly increased (9.95%) mean acceleration response was observed post hoc in the batch of MTI instruments, in which a significantly reduced inter-instrumental reliability
Directory of Open Access Journals (Sweden)
Andersen Lars B
2008-04-01
Full Text Available Abstract Background Potentially, unit-specific in-vitro calibration of accelerometers could increase field data quality and study power. However, reduced inter-unit variability would only be important if random instrument variability contributes considerably to the total variation in field data. Therefore, the primary aim of this study was to calculate and apply unit-specific calibration factors in multiple accelerometers in order to examine the impact on random output variation caused by inter-instrument variability. Methods Instrument-specific calibration factors were estimated in 25 MTI- and 53 CSA accelerometers in a mechanical setup using four different settings varying in frequencies and/or amplitudes. Calibration effect was analysed by comparing raw and calibrated data after applying unit-specific calibration factors to data obtained during quality checks in a mechanical setup and to data collected during free living conditions. Results Calibration reduced inter-instrument variability considerably in the mechanical setup, both in the MTI instruments (raw SDbetween units = 195 counts*min-1 vs. calibrated SDbetween units = 65 counts*min-1 and in the CSA instruments (raw SDbetween units = 343 counts*min-1 vs. calibrated SDbetween units = 67 counts*min-1. However, the effect of applying the derived calibration to children's and adolescents' free living physical activity data did not alter the coefficient of variation (CV (children: CVraw = 30.2% vs. CVcalibrated = 30.4%, adolescents: CVraw = 36.3% vs. CVcalibrated = 35.7%. High correlations (r = 0.99 & r = 0.98, respectively were observed between raw and calibrated field data, and the proportion of the total variation caused by the MTI- and CSA monitor was estimated to be only 1.1% and 4.2%, respectively. Compared to the CSA instruments, a significantly increased (9.95% mean acceleration response was observed post hoc in the batch of MTI instruments, in which a significantly reduced inter
Institute of Scientific and Technical Information of China (English)
GUO TieXin; CHEN XinXiang
2009-01-01
The purpose of this paper is to provide a random duality theory for the further development of the theory of random conjugate spaces for random normed modules.First,the complicated stratification structure of a module over the algebra L(μ,K) frequently makes our investigations into random duality theory considerably different from the corresponding ones into classical duality theory,thus in this paper we have to first begin in overcoming several substantial obstacles to the study of stratification structure on random locally convex modules.Then,we give the representation theorem of weakly continuous canonical module homomorphisms,the theorem of existence of random Mackey structure,and the random bipolar theorem with respect to a regular random duality pair together with some important random compatible invariants.
Institute of Scientific and Technical Information of China (English)
无
2009-01-01
The purpose of this paper is to provide a random duality theory for the further development of the theory of random conjugate spaces for random normed modules. First, the complicated stratification structure of a module over the algebra L(μ, K) frequently makes our investigations into random duality theory considerably difierent from the corresponding ones into classical duality theory, thus in this paper we have to first begin in overcoming several substantial obstacles to the study of stratification structure on random locally convex modules. Then, we give the representation theorem of weakly continuous canonical module homomorphisms, the theorem of existence of random Mackey structure, and the random bipolar theorem with respect to a regular random duality pair together with some important random compatible invariants.
Jellish, W S; Thalji, Z; Stevenson, K; Shea, J
1996-09-01
General or regional anesthesia may be used for lumbar laminectomy. To determine whether one method is superior, 122 patients were randomly assigned to receive either a standard general anesthetic (GA) or spinal anesthesia (SA) supplemented with intravenous (IV) propofol sedation. Data from the intraoperative period through hospital discharge were collected and compared. Demographically, both groups were similar. Total anesthesia (131.0 +/- 4.3 vs 106.6 +/- 3.2 min) and surgical times (81.5 +/- 3.6 vs 67.1 +/- 2.8 min) were longer in the GA group. Intraoperative hemodynamics were similar between groups except that the incidence of increased blood pressure was more frequent with GA (26.2% vs 3.3%). Blood loss was less during SA (133 +/- 18 mL vs 221 +/- 32 mL). Postanesthesia care unit (PACU) heart rates and mean arterial pressures were higher in the GA group. Peak pain scores in the PACU were higher after GA compared with SA (58 +/- 4 vs 22 +/- 3) as were the number of patients who required analgesics. Severe nausea was more common in the GA group both in the PACU and during the 24 h after surgery. Analgesic requirements after discharge from the PACU, urinary retention, and days in the hospital did not differ between groups. This study suggests that SA may be superior to GA both intraoperatively and postoperatively for lumbar spine procedures lasting less than 2 h. PMID:8780281
Wrigge, Hermann; Zinserling, Jörg; Neumann, Peter; Muders, Thomas; Magnusson, Anders; Putensen, Christian; Hedenstierna, Göran
2005-01-01
Introduction Experimental and clinical studies have shown a reduction in intrapulmonary shunt with spontaneous breathing during airway pressure release ventilation (APRV) in acute lung injury. This reduction was related to reduced atelectasis and increased aeration. We hypothesized that spontaneous breathing will result in better ventilation and aeration of dependent lung areas and in less cyclic collapse during the tidal breath. Methods In this randomized controlled experimental trial, 22 pi...
International Nuclear Information System (INIS)
To analyse the frequency of re-planning and its variability dependent on the IGRT correction strategy and on the modification of the dosimetric criteria for re-planning for the spinal cord in head and neck IG-IMRT. Daily kV-control-CTs of six head and neck patients (=175 CTs) were analysed. All volumes of interest were re-contoured using deformable image registration. Three IGRT correction strategies were simulated and the resulting dose distributions were computed for all fractions. Different sets of criteria with varying dose thresholds for re-planning were investigated. All sets of criteria ensure equivalent target coverage of both CTVs, but vary in the tolerance threshold of the spinal cord. The variations of the D95 and D2 in respect to the planned values ranged from -7% to +3% for both CTVs, and -2% to +6% for the spinal cord. Despite different correction vectors of the three IGRT strategies, the dosimetric differences were small. The number of fractions not requiring re-planning varied between 0% and 11% dependent on the applied IGRT correction strategy. In contrast, this number ranged between 32% and 70% dependent on the dosimetric thresholds, even though these thresholds were only gently modified. The more precise the planned dose needs to be maintained over the treatment course, the more frequently re-planning is required. The influence of different IGRT correction strategies, even though geometrically notable, was found to be of only limited relevance for the re-planning frequency. In contrast, the definition and modification of thresholds for re-planning have a major impact on the re-planning frequency
International Nuclear Information System (INIS)
Random Amplified Polymorphic DNA (RAPDs) markers were utilized to detect polymorphism between pure lines and commercially available Basmati rice varieties to assess variation which may be helpful in quality control and varietal identification (Basmati-370 and derived radiation induced mutants), differentiation of mutants and parents, and identification of RAPD markers co-segregating with important agronomic traits including plant height, days to flower and grain quality. Basmati varieties were distinguished from non-Basmati varieties with the help of five diagnostic markers which will be useful for detecting mixing of non-Basmati and Basmati rices, currently a serious marketing problem. Different Basmati cultivars were identified with the help of diagnostic RAPD markers which can be used in quality control as well as for ''fingerprinting'' of cultivars. Different radiation induced mutants were also successfully distinguished from the parents on the basis of variety specific and mutant specific markers which will be useful for varietal identification. In addition to this, other markers were also identified which can differentiate mutants from each other and are being, used for the fingerprinting of different mutants, particularly the dwarf mutants having similar appearance but different parentage. For identification of RAPD markers co-segregating with plant height and days to flower, 50 F2 plants and four F3 families were studied from a reciprocal cross made between Kashmir Basmati (tall and early) and Basmati-198 (dwarf and late). Segregating bands were observed within these populations, and indicating the possible use of RAPD markers for tagging gene(s) of agronomic importance in rice. (author)
Cossa-Moiane, I L; Mendes, T; Ferreira, T M; Mauricio, I; Calado, M; Afonso, A; Belo, S
2015-11-01
Schistosomiasis is a parasitic disease caused by flatworms of the genus Schistosoma. Among the Schistosoma species known to infect humans, S. mansoni is the most frequent cause of intestinal schistosomiasis in sub-Saharan Africa and South America: the World Health Organization estimates that about 200,000 deaths per year result from schistosomiasis in sub-Saharan Africa alone. The Schistosoma life cycle requires two different hosts: a snail as intermediate host and a mammal as definitive host. People become infected when they come into contact with water contaminated with free-living larvae (e.g. when swimming, fishing, washing). Although S. mansoni has mechanisms for escaping the host immune system, only a minority of infecting larvae develop into adults, suggesting that strain selection occurs at the host level. To test this hypothesis, we compared the Belo Horizonte (BH) strain of S. mansoni recovered from definitive hosts with different immunological backgrounds using random amplification of polymorphic DNA-polymerase chain reaction (RAPD-PCR). Schistosoma mansoni DNA profiles of worms obtained from wild-type (CD1 and C57BL/6J) and mutant (Jα18- / - and TGFβRIIdn) mice were analysed. Four primers produced polymorphic profiles, which can therefore potentially be used as reference biomarkers. All male worms were genetically distinct from females isolated from the same host, with female worms showing more specific fragments than males. Of the four host-derived schistosome populations, female and male adults recovered from TGFβRIIdn mice showed RAPD-PCR profiles that were most similar to each other. Altogether, these data indicate that host immunological backgrounds can influence the genetic diversity of parasite populations. PMID:24991919
A Composite Likelihood Inference in Latent Variable Models for Ordinal Longitudinal Responses
Vasdekis, Vassilis G. S.; Cagnone, Silvia; Moustaki, Irini
2012-01-01
The paper proposes a composite likelihood estimation approach that uses bivariate instead of multivariate marginal probabilities for ordinal longitudinal responses using a latent variable model. The model considers time-dependent latent variables and item-specific random effects to be accountable for the interdependencies of the multivariate…
Dynamic Quantum Allocation and Swap-Time Variability in Time-Sharing Operating Systems.
Bhat, U. Narayan; Nance, Richard E.
The effects of dynamic quantum allocation and swap-time variability on central processing unit (CPU) behavior are investigated using a model that allows both quantum length and swap-time to be state-dependent random variables. Effective CPU utilization is defined to be the proportion of a CPU busy period that is devoted to program processing, i.e.…
Satoh, N.; Fukuda, H.; Miyairi, Y.; Yokoyama, Y.; Nagata, T.
2015-12-01
Radiocarbon in dissolved inorganic carbon (DIC) in seawater varies greatly, both geographically and with depth. This "reservoir effect" is thought to be reflected in the radiocarbon content (∆14C) of marine organisms, via DIC fixation by primary producers and subsequent trophic transfer. The ∆14C of marine organismal soft tissues might thus provide unique information about their habitats, diets, migration and other environmental histories. However, the effectiveness of this approach has yet to be extensively explored, with data on ∆14C variability in soft tissues of marine organisms being markedly limited. Here we examined whether ∆14C values of individual pinnate blades (leaf-like structures) of brown seaweed (Undaria pinnatifida) reflect the ∆14C of DIC in the water current prevailing at the time of blade formation. The study was conducted in Otsuchi Bay located in the Sanriku coastal region, northeastern Japan, where 14C-depleted cold Oyashio current and warm Tsugaru current (high ∆14C) converge, affecting the physiology and growth of marine organisms growing there. U. pinnatifida individuals cultured in the bay (length of saprophytes, 140-215 cm) were harvested in April 2014 and ∆14C of blades were determined by accelerator mass spectrometry. Younger blades formed after the Oyashio water intrusion had significantly lower ∆14C values compared to older blades formed before the event. The ∆14C values of younger and older blades were generally consistent with the ∆14C of DIC in Oyashio (-60.5 ‰) and Tsugaru (24.9 ‰) waters, respectively. Thus, despite possible turnover of organic carbon in seaweed soft tissues, blade-order-dependent ∆14C variability appeared to strongly reflect the Oyashio intrusion event (radiocarbon shift) in the bay.
Groeneveld, Marleen G.; Harriet J. Vermeer; van IJzendoorn, Marinus H.; Linting, Mariëlle
2016-01-01
Background The childcare environment offers a wide array of developmental opportunities for children. Providing children with a feeling of security to explore this environment is one of the most fundamental goals of childcare. Objective In the current study the effectiveness of Video-feedback Intervention to promote Positive Parenting-Child Care (VIPP-CC) was tested on children’s wellbeing in home-based childcare in a randomized controlled trial. Methods Forty-seven children and their caregiv...
Directory of Open Access Journals (Sweden)
Juliana Petrini
2012-12-01
Full Text Available The objective of this work was to assess the degree of multicollinearity and to identify the variables involved in linear dependence relations in additive-dominant models. Data of birth weight (n=141,567, yearling weight (n=58,124, and scrotal circumference (n=20,371 of Montana Tropical composite cattle were used. Diagnosis of multicollinearity was based on the variance inflation factor (VIF and on the evaluation of the condition indexes and eigenvalues from the correlation matrix among explanatory variables. The first model studied (RM included the fixed effect of dam age class at calving and the covariates associated to the direct and maternal additive and non-additive effects. The second model (R included all the effects of the RM model except the maternal additive effects. Multicollinearity was detected in both models for all traits considered, with VIF values of 1.03 - 70.20 for RM and 1.03 - 60.70 for R. Collinearity increased with the increase of variables in the model and the decrease in the number of observations, and it was classified as weak, with condition index values between 10.00 and 26.77. In general, the variables associated with additive and non-additive effects were involved in multicollinearity, partially due to the natural connection between these covariables as fractions of the biological types in breed composition.O objetivo deste trabalho foi avaliar o grau de multicolinearidade e identificar as variáveis envolvidas na dependência linear em modelos aditivo-dominantes. Foram utilizados dados de peso ao nascimento (n=141.567, peso ao ano (n=58.124 e perímetro escrotal (n=20.371 de bovinos de corte compostos Montana Tropical. O diagnóstico de multicolinearidade foi baseado no fator de inflação de variância (VIF e no exame dos índices de condição e dos autovalores da matriz de correlações entre as variáveis explanatórias. O primeiro modelo estudado (RM incluiu o efeito fixo de classe de idade da mãe ao parto e
Exponential-family Random Network Models
Fellows, I; Handcock, MS
2012-01-01
Random graphs, where the connections between nodes are considered random variables, have wide applicability in the social sciences. Exponential-family Random Graph Models (ERGM) have shown themselves to be a useful class of models for representing com- plex social phenomena. We generalize ERGM by also modeling nodal attributes as random variates, thus creating a random model of the full network, which we call Exponential-family Random Network Models (ERNM). We demonstrate how this framework a...
Directory of Open Access Journals (Sweden)
Soichiro Kaneko
2013-01-01
Full Text Available Objective. We investigated the relationship between superior mesenteric artery blood flow volume (SMA BFV and autonomic nerve activity in acupuncture stimulation of lower limb points through heart rate variability (HRV evaluations. Methods. Twenty-six healthy volunteers underwent crossover applications of bilateral manual acupuncture stimulation at ST36 or LR3 or no stimulation. Heart rate, blood pressure, cardiac index, systemic vascular resistance index, SMA BFV, and HRV at rest and 30 min after the intervention were analyzed. Results. SMA BFV showed a significant increase after ST36 stimulation (0% to 14.1% ± 23.4%, P=0.007; very low frequency (VLF, high frequency (HF, low frequency (LF, and LF/HF were significantly greater than those at rest (0% to 479.4% ± 1185.6%, P=0.045; 0% to 78.9% ± 197.6%, P=0.048; 0% to 123.9% ± 217.1%, P=0.006; 0% to 71.5% ± 171.1%, P=0.039. Changes in HF and LF also differed significantly from those resulting from LR3 stimulation (HF: 78.9% ± 197.6% versus −18.2% ± 35.8%, P=0.015; LF: 123.9% ± 217.1% versus 10.6% ± 70.6%, P=0.013. Conclusion. Increased vagus nerve activity after ST36 stimulation resulted in increased SMA BFV. This partly explains the mechanism of acupuncture-induced BFV changes.
Kaneko, Soichiro; Watanabe, Masashi; Takayama, Shin; Numata, Takehiro; Seki, Takashi; Tanaka, Junichi; Kanemura, Seiki; Kagaya, Yutaka; Ishii, Tadashi; Kimura, Yoshitaka; Yaegashi, Nobuo
2013-01-01
Objective. We investigated the relationship between superior mesenteric artery blood flow volume (SMA BFV) and autonomic nerve activity in acupuncture stimulation of lower limb points through heart rate variability (HRV) evaluations. Methods. Twenty-six healthy volunteers underwent crossover applications of bilateral manual acupuncture stimulation at ST36 or LR3 or no stimulation. Heart rate, blood pressure, cardiac index, systemic vascular resistance index, SMA BFV, and HRV at rest and 30 min after the intervention were analyzed. Results. SMA BFV showed a significant increase after ST36 stimulation (0% to 14.1% ± 23.4%, P = 0.007); very low frequency (VLF), high frequency (HF), low frequency (LF), and LF/HF were significantly greater than those at rest (0% to 479.4% ± 1185.6%, P = 0.045; 0% to 78.9% ± 197.6%, P = 0.048; 0% to 123.9% ± 217.1%, P = 0.006; 0% to 71.5% ± 171.1%, P = 0.039). Changes in HF and LF also differed significantly from those resulting from LR3 stimulation (HF: 78.9% ± 197.6% versus -18.2% ± 35.8%, P = 0.015; LF: 123.9% ± 217.1% versus 10.6% ± 70.6%, P = 0.013). Conclusion. Increased vagus nerve activity after ST36 stimulation resulted in increased SMA BFV. This partly explains the mechanism of acupuncture-induced BFV changes. PMID:24381632
Miller, Joseph S.; Rute, Jason
2015-01-01
Energy randomness is a notion of partial randomness introduced by Diamondstone and Kjos-Hanssen to characterize the sequences that can be elements of a Martin-L\\"of random closed set (in the sense of Barmpalias, Brodhead, Cenzer, Dashti, and Weber). It has also been applied by Allen, Bienvenu, and Slaman to the characterization of the possible zero times of a Martin-L\\"of random Brownian motion. In this paper, we show that $X \\in 2^\\omega$ is $s$-energy random if and only if $\\sum_{n\\in\\omega...
A Stochastic Collocation Method for Elliptic Partial Differential Equations with Random Input Data
Babuška, Ivo
2010-01-01
This work proposes and analyzes a stochastic collocation method for solving elliptic partial differential equations with random coefficients and forcing terms. These input data are assumed to depend on a finite number of random variables. The method consists of a Galerkin approximation in space and a collocation in the zeros of suitable tensor product orthogonal polynomials (Gauss points) in the probability space, and naturally leads to the solution of uncoupled deterministic problems as in the Monte Carlo approach. It treats easily a wide range of situations, such as input data that depend nonlinearly on the random variables, diffusivity coefficients with unbounded second moments, and random variables that are correlated or even unbounded. We provide a rigorous convergence analysis and demonstrate exponential convergence of the “probability error” with respect to the number of Gauss points in each direction of the probability space, under some regularity assumptions on the random input data. Numerical examples show the effectiveness of the method. Finally, we include a section with developments posterior to the original publication of this work. There we review sparse grid stochastic collocation methods, which are effective collocation strategies for problems that depend on a moderately large number of random variables.
LENUS (Irish Health Repository)
Hooi, Paul
2013-01-01
To determine how the variability in biaxial flexure strength of a soda-lime glass analogue for a PLV and DBC material was influenced by precementation operative variables and following resin-cement coating.
MC Estimator Variance Reduction with Antithetic and Common Random Fields
Guthke, P.; Bardossy, A.
2011-12-01
Monte Carlo methods are widely used to estimate the outcome of complex physical models. For physical models with spatial parameter uncertainty, it is common to apply spatial random functions to the uncertain variables, which can then be used to interpolate between known values or to simulate a number of equally likely realizations .The price, that has to be paid for such a stochastic approach, are many simulations of the physical model instead of just running one model with one 'best' input parameter set. The number of simulations is often limited because of computational constraints, so that a modeller has to make a compromise between the benefit in terms of an increased accuracy of the results and the effort in terms of a massively increased computational time. Our objective is, to reduce the estimator variance of dependent variables in Monte Carlo frameworks. Therefore, we adapt two variance reduction techniques (antithetic variates and common random numbers) to a sequential random field simulation scheme that uses copulas as spatial dependence functions. The proposed methodology leads to pairs of spatial random fields with special structural properties, that are advantageous in MC frameworks. Antithetic Random fields (ARF) exhibit a reversed structure on the large scale, while the dependence on the local scale is preserved. Common random fields (CRF) show the same large scale structures, but different spatial dependence on the local scale. The performances of the proposed methods are examined with two typical applications of stochastic hydrogeology. It is shown, that ARF have the property to massively reduce the number of simulation runs required for convergence in Monte Carlo frameworks while keeping the same accuracy in terms of estimator variance. Furthermore, in multi-model frameworks like in sensitivity analysis of the spatial structure, where more than one spatial dependence model is used, the influence of different dependence structures becomes obvious
Directory of Open Access Journals (Sweden)
Luís André Castro
2009-01-01
Full Text Available OBJETIVO: O objetivo deste estudo é avaliar a eficácia da naltrexona com intervenção breve em pacientes com dependência de álcool. MÉTODO: Este estudo é um ensaio clínico randomizado, duplo-cego, placebo-controlado de 12 semanas. A amostra de 71 pacientes foi dividida randomicamente em dois grupos (um recebendo naltrexona e outro placebo. Sujeitos dependentes de álcool foram tratados com 50 mg de naltrexona ou placebo diariamente por 12 semanas. Ambos os grupos de tratamento receberam intervenção breve. Os desfechos clínicos primários para este estudo foram taxa de recaída e mudança no padrão de consumo de álcool. RESULTADOS: Na intenção de tratar, menor porcentagem de sujeitos tratados com naltrexona recaíram (3% 21%; p = 0,054. Naltrexona com intervenção breve não foi superior ao placebo para diminuir os dias de consumo (6,2 + 10,6 3,05 + 7,3; p = 0,478, os dias de consumo moderado (0 2,2 + 6,9; p = 0,345 e os dias de consumo pesado (0,03 + 0,2 0,3 + 0,9; p = 0,887. Naltrexona foi bem tolerada. Os efeitos adversos mais frequentes na presente amostra foram: cefaleia (25,4%, sonolência (20,9%, náuseas (16,4%, hiperfagia (16,4%, anorexia (14,9%, ansiedade (10,4%, pirose (10,4% e irritabilidade (10,4%. CONCLUSÕES: Embora o grupo naltrexona tenha demonstrado tendência para reduzir taxa de recaída (> 5 doses/dia, não foi encontrada nenhuma diferença em outras variáveis de consumo de álcool entre os grupos naltrexona e placebo. Estudos futuros devem examinar a eficácia desse tipo de combinação de tratamento nos cuidados primários de saúde.OBJECTIVE: The objective of this study is to evaluate the efficacy of naltrexone with brief intervention among patients with alcohol dependence. METHOD: This study is a 12-week randomized, double blind, placebo-controlled clinical trial. The sample of 71 patients was randomly divided in two groups (one receiving naltrexone and the other placebo. Alcohol-dependent subjects were
Energy Technology Data Exchange (ETDEWEB)
Asvany, O.; Savic, I.; Schlemmer, S.; Gerlich, D
2004-03-08
Reactions of methane cations, CH{sub 4}{sup +}, with H{sub 2}, HD and D{sub 2} have been studied in a variable temperature 22-pole ion trap from room temperature down to 15 K. The formation of CH{sub 5}{sup +} in collisions with H{sub 2} is slow at 300 K, but it becomes faster by at least one order of magnitude when the temperature is lowered to 15 K. This behavior is tentatively explained with a longer complex lifetime at low temperatures. However, since tunneling is most probably not responsible for product formation, other dynamical or statistical restrictions must be responsible for the negative temperature dependence. In collisions of CH{sub 4}{sup +} with HD, the CH{sub 5}{sup +} product ion (68% at 15 K) prevails over CH{sub 4}D{sup +} (32%). Reaction of CH{sub 4}{sup +} with D{sub 2} is found to be much slower than with H{sub 2} or HD. The rate coefficient for converting CH{sub 4}{sup +} into CH{sub 3}D{sup +} by H-D exchange has been determined to be smaller than 10{sup -12} cm{sup 3}/s, indicating that scrambling in the CH{sub 6}{sup +} complex is very unlikely.
Random fixed point theorems on product spaces
Ismat Beg; Naseer Shahzad
1993-01-01
The existence of random fixed point of a locally contractive random operator in first variable on product spaces is proved. The concept continuous random height-selection is discussed. Some random fixed point theorems for nonexpansive self and nonself maps are also obtained in product spaces.
LENUS (Irish Health Repository)
Madigan, Kevin
2013-01-01
Patients who experience the onset of psychotic illness with a comorbid diagnosis of cannabis dependence experience poor clinical outcomes. Few studies have identified interventions that reduce cannabis use and improve clinical outcome in this population.
Random walkers versus random crowds: diffusion of large matrices
Gudowska-Nowak, Ewa; Janik, Romuald J.; Jurkiewicz, Jerzy; Nowak, Maciej A.; Wieczorek, Waldemar
2006-01-01
We briefly review the random matrix theory for large N by N matrices viewed as free random variables in a context of stochastic diffusion. We establish a surprising link between the spectral properties of matrix-valued multiplicative diffusion processes for hermitian and unitary ensembles.
Directory of Open Access Journals (Sweden)
Ho Chiang-Hong
2011-02-01
Full Text Available Abstract Background Hyperphosphatemia in patients with chronic kidney disease (CKD contributes to secondary hyperparathyroidism, soft tissue calcification, and increased mortality risk. This trial was conducted to examine the efficacy and safety of calcium acetate in controlling serum phosphorus in pre-dialysis patients with CKD. Methods In this randomized, double-blind, placebo-controlled trial, 110 nondialyzed patients from 34 sites with estimated GFR 2 and serum phosphorus > 4.5 mg/dL were randomized to calcium acetate or placebo for 12 weeks. The dose of study drugs was titrated to achieve target serum phosphorus of 2.7-4.5 mg/dL. Serum phosphorus, calcium, iPTH, bicarbonate and serum albumin were measured at baseline and every 2 weeks for the 12 week study period. The primary efficacy endpoint was serum phosphorus at 12 weeks. Secondary endpoints were to measure serum calcium and intact parathyroid hormone (iPTH levels. Results At 12 weeks, serum phosphorus concentration was significantly lower in the calcium acetate group compared to the placebo group (4.4 ± 1.2 mg/dL vs. 5.1 ± 1.4 mg/dL; p = 0.04. The albumin-adjusted serum calcium concentration was significantly higher (9.5 ± 0.8 vs. 8.8 ± 0.8; p p Conclusions In CKD patients not yet on dialysis, calcium acetate was effective in reducing serum phosphorus and iPTH over a 12 week period. Trial Registration www.clinicaltrials.gov NCT00211978.
Coupled continuous time random walks in finance
Meerschaert, M M; Meerschaert, Mark M.; Scalas, Enrico
2006-01-01
Continuous time random walks (CTRWs) are used in physics to model anomalous diffusion, by incorporating a random waiting time between particle jumps. In finance, the particle jumps are log-returns and the waiting times measure delay between transactions. These two random variables (log-return and waiting time) are typically not independent. For these coupled CTRW models, we can now compute the limiting stochastic process (just like Brownian motion is the limit of a simple random walk), even in the case of heavy tailed (power-law) price jumps and/or waiting times. The probability density functions for this limit process solve fractional partial differential equations. In some cases, these equations can be explicitly solved to yield descriptions of long-term price changes, based on a high-resolution model of individual trades that includes the statistical dependence between waiting times and the subsequent log-returns. In the heavy tailed case, this involves operator stable space-time random vectors that genera...
Institute of Scientific and Technical Information of China (English)
周任军; 刘志勇; 李献梅; 陈瑞先; 闵雄帮; 尹权
2014-01-01
The benefit of carbon capture unit closely relates with electricity price and price of carbon emission permit, in the optimization model of unit carbon capture rate, in which the cost of electricity selling, the cost of carbon emission permit transaction cost and the fuel cost are taken as variables in objective function, the randomness of the electricity price and the price of carbon emission permit are considered simultaneously, and a multiple random variable superquantile method is proposed and derived to turn the optimization model of unit carbon capture rate into the optimization model of unit carbon capture rate in the form of random function that is easy to solve by toolbox. Three kinds of calculation results, namely the price fluctuations of both electricity and carbon emission permit are not considered, only the price fluctuation of carbon emission permit is considered and the price fluctuations of both electricity and carbon emission permit are considered, are contrasted and analyzed. Case simulation results show that considering the price randomness of both electricity and carbon emission permit the flexibility of power grid to adjust the carbon capture rate is enhanced; the mechanism of electricity market and carbon trading market is actively responded, thus the overall operating cost of carbon capture system can be reduced.%碳捕集机组的效益与电价、碳排放权价格密切相关，在售电损失费用、碳排放权交易费用和燃料费用为目标函数的机组碳捕集率优化模型中，同时考虑电价与碳排放权价格的随机性，提出并推导了多随机变量超分位数方法，将机组碳捕集率优化模型变为机组碳捕集率随机函数型的优化模型，便于利用工具箱求解。对比分析了不考虑电价和碳排放权价格波动，仅考虑碳排放权价格波动以及考虑电价与碳排放权价格波动的机组碳捕集率优化模型的3种计算结果。算例仿真结果表明，同
International Nuclear Information System (INIS)
An actual clinical trial showed the effect of low dose radiotherapy in painful heel spur (plantar fasciitis) with single doses of 1.0 Gy and total doses of 6.0 Gy applied twice weekly. Furthermore, a lot of animal experimental and in vitro data reveals the effect of lower single doses of 0.5 Gy which may be superior in order to ease pain and reduce inflammation in patients with painful heel spur. Our goal is therefore to transfer this experimentally found effect into a randomized multicenter trial. This was a controlled, prospective, two-arm phase III-multicenter trial. The standard arm consisted of single fractions of 1.0 Gy applied two times a week, for a total dose of 6.0 Gy (total therapy time: 3 weeks). The experimental arm consisted of single fractions of 0.5 Gy applied 3 times a week, for a total dose of 6.0 Gy (total therapy time: 4 weeks). Following a statistical power calculation, there were 120 patients for each investigation arm. The main inclusion criteria were: age > = 40 years, clinical and radiologically diagnosed painful heel spur (plantar fasciitis), and current symptoms for at least 6 months. The main exclusion criteria were: former local trauma, surgery or radiotherapy of the heel; pregnant or breastfeeding women; and a pre-existing severe psychiatric or psychosomatic disorder. After approving a written informed consent the patients are randomized by a statistician into one of the trial arms. After radiotherapy, the patients are seen after six weeks, after twelve weeks and then every twelve weeks up to 48 weeks. Additionally, they receive a questionnaire every six weeks after the follow-up examinations up to 48 weeks. The effect is measured using the visual analogue scale of pain (VAS), the calcaneodynia score according to Rowe and the SF-12 score. The primary endpoint is the pain relief three months after therapy. Patients of both therapy arms with an insufficient result are offered a second radiotherapy series applying the standard dose
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Different means of applying numerical techniques are proposed, typically used for pattern recognition purposes and for artificial texture classification and segmentation, to study the evolution of magnetization at the nano- and micro-scale in ferromagnetic samples. This framework is applied both to the Magnetic Force Microscope (MFM) dataset and to synthetic binary patterns of 2-dimensional spins, based on a nucleation and growth model for the hysteresis. In general 2-dimensional gray-scale frames carry information characterized by a spatial correlation between each pixel. Multiple datasets as the one analyzed, either 256-bit-valued magnetic field dependent MFM matrices or 2-bit-valued synthetic field dependent scatter matrices, are arranged as multidimensional arrays and their 2-dimensional entropy is computed.
Directory of Open Access Journals (Sweden)
David Cameron-Smith
2009-12-01
Full Text Available The effect of resistance exercise with the ingestion of supplementary protein on the activation of the mTOR cascade, in human skeletal muscle has not been fully elucidated. In this study, the impact of a single bout of resistance exercise, immediately followed by a single dose of whey protein isolate (WPI or placebo supplement, on the activation of mTOR signalling was analyzed. Young untrained men completed a maximal single-legged knee extension exercise bout and were randomized to ingest either WPI supplement (n = 7 or the placebo (n = 7. Muscle biopsies were taken from the vastus lateralis before, and 2, 4 and 24 hr post-exercise. WPI or placebo ingestion consumed immediately post-exercise had no impact on the phosphorylation of Akt (Ser473. However, WPI significantly enhanced phosphorylation of mTOR (Ser2448, 4E-BP1 (Thr37/46 and p70S6K (Thr389 at 2 hr post-exercise. This study demonstrates that a single dose of WPI, when consumed in modest quantities, taken immediately after resistance exercise elicits an acute and transient activation of translation initiation within the exercised skeletal muscle.
Kim, Sungjun; Park, Byung-Gook
2016-12-01
A study on the bipolar-resistive switching of an Ni/SiN/Si-based resistive random-access memory (RRAM) device shows that the influences of the reset power and the resistance value of the low-resistance state (LRS) on the reset-switching transitions are strong. For a low LRS with a large conducting path, the sharp reset switching, which requires a high reset power (>7 mW), was observed, whereas for a high LRS with small multiple-conducting paths, the step-by-step reset switching with a low reset power (<7 mW) was observed. The attainment of higher nonlinear current-voltage (I-V) characteristics in terms of the step-by-step reset switching is due to the steep current-increased region of the trap-controlled space charge-limited current (SCLC) model. A multilevel cell (MLC) operation, for which the reset stop voltage (V STOP) is used in the DC sweep mode and an incremental amplitude is used in the pulse mode for the step-by-step reset switching, is demonstrated here. The results of the present study suggest that well-controlled conducting paths in a SiN-based RRAM device, which are not too strong and not too weak, offer considerable potential for the realization of low-power and high-density crossbar-array applications. PMID:27518231
Goodness-of-fit tests with dependent observations
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We revisit the Kolmogorov–Smirnov and Cramér–von Mises goodness-of-fit (GoF) tests and propose a generalization to identically distributed, but dependent univariate random variables. We show that the dependence leads to a reduction of the 'effective' number of independent observations. The generalized GoF tests are not distribution-free but rather depend on all the lagged bivariate copulas. These objects, that we call 'self-copulas', encode all the non-linear temporal dependences. We introduce a specific, log-normal model for these self-copulas, for which a number of analytical results are derived. An application to financial time series is provided. As is well known, the dependence is to be long-ranged in this case, a finding that we confirm using self-copulas. As a consequence, the acceptance rates for GoF tests are substantially higher than if the returns were iid random variables
Random effects coefficient of determination for mixed and meta-analysis models.
Demidenko, Eugene; Sargent, James; Onega, Tracy
2012-01-01
The key feature of a mixed model is the presence of random effects. We have developed a coefficient, called the random effects coefficient of determination, [Formula: see text], that estimates the proportion of the conditional variance of the dependent variable explained by random effects. This coefficient takes values from 0 to 1 and indicates how strong the random effects are. The difference from the earlier suggested fixed effects coefficient of determination is emphasized. If [Formula: see text] is close to 0, there is weak support for random effects in the model because the reduction of the variance of the dependent variable due to random effects is small; consequently, random effects may be ignored and the model simplifies to standard linear regression. The value of [Formula: see text] apart from 0 indicates the evidence of the variance reduction in support of the mixed model. If random effects coefficient of determination is close to 1 the variance of random effects is very large and random effects turn into free fixed effects-the model can be estimated using the dummy variable approach. We derive explicit formulas for [Formula: see text] in three special cases: the random intercept model, the growth curve model, and meta-analysis model. Theoretical results are illustrated with three mixed model examples: (1) travel time to the nearest cancer center for women with breast cancer in the U.S., (2) cumulative time watching alcohol related scenes in movies among young U.S. teens, as a risk factor for early drinking onset, and (3) the classic example of the meta-analysis model for combination of 13 studies on tuberculosis vaccine. PMID:23750070
Josephine, Faass; Michael, Lahr
2007-01-01
This paper is an investigation into the relative importance of a wide variety of factors in influencing whether members of the American public support or oppose the use of biotechnology in agriculture and food production. To accomplish this end, as well as to facilitate the examination of a large number of independent variables simultaneously, several statistical methods, including factor analyses, instrumental variables analysis, and probit and logistic regressions were performed. It was d...
Janssens, Lizanne; Stoks, Robby
2013-01-01
Interactions between pollutants and suboptimal environmental conditions can have severe consequences for the toxicity of pollutants, yet are still poorly understood. To identify patterns across environmental conditions and across fitness-related variables we exposed Enallagma cyathigerum damselfly larvae to the pesticide chlorpyrifos at two food levels or at two temperatures and quantified four fitness-related variables (larval survival, development time, mass at emergence and adult cold resi...
Variational Infinite Hidden Conditional Random Fields
Bousmalis, Konstantinos; Zafeiriou, Stefanos; Morency, Louis-Philippe; Pantic, Maja; Ghahramani, Zoubin
2015-01-01
Hidden conditional random fields (HCRFs) are discriminative latent variable models which have been shown to successfully learn the hidden structure of a given classification problem. An Infinite hidden conditional random field is a hidden conditional random field with a countably infinite number of
Behaviors Predicting Foot Lesions in Patients with Non-Insulin-Dependent Diabetes Mellitus
Suico, Jeffrey G.; Marriott, Deanna J; Vinicor, Frank; Litzelman, Debra K.
1998-01-01
Associations between specific foot-care behaviors and foot lesions in patients with non-insulin-dependent diabetes mellitus were prospectively investigated. Data from a randomized controlled trial for preventing diabetic foot lesions were analyzed as a prospective cohort using logistic regression. Independent variables included foot-care behaviors, patient self-foot examination, going barefoot, availability of foot-care assistance, and visits to health-care providers. The dependent variable w...
Nemoto, Masaru; Hashimoto, Takuya; Miura, Sumio; Urabe, Go; Nakazawa, Tatsu; Hosaka, Akihiro; Kato, Masaaki; Ohkubo, Nobukazu; Miyairi, Takeshi; Okamoto, Hiroyuki; Shigematsu, Kunihiro; Miyata, Tetsuro
2013-01-01
Outcomes of abdominal aortic aneurysm (AAA) repair have improved in the 2 decades since the emergence of endovascular aneurysm repair (EVAR). However, EVAR is considered a contraindication for shaggy aorta because of the high risk of shower embolization. Recently, statins have been implicated in preventing embolization in patients with shaggy aorta via its pleiotropic effects, including atheroma reduction and coronary artery stabilization. We selected pitavastatin, a statin with potent effects, discovered and developed by a Japanese company because it has shown excellent pleiotropic effects on atheromatous arteries in the Japanese population. A randomized comparison study of dose-dependent effects of pitavastatin in patients with AAA with massive atheromatous aortic thrombus (PROCEDURE study) has begun. PROCEDURE has an enrollment goal of up to 80 patients with AAA with massive aortic atheroma (excluding intrasac atheroma), randomly allocated into 2 groups receiving pitavastatin at a dose of 1 or 4 mg/day. The endpoints of the PROCEDURE study include change in atheroma volume, major adverse events related to shower embolization after aneurysm repair, and lipid-lowering effects. When complete, results of the PROCEDURE study should provide objective evidence to use statins preoperatively for AAA with massive aortic atheroma. PMID:23641286
Passive scalar intermittency in random flows
Lin, Zhi
2007-06-01
This thesis concentrates on reconstructing the complete probability density function (PDF) for a passive scalar governed by a random advection-diffusion equation using a variety of mathematical tools, primarily from partial differential equations, perturbation theory, numerical analysis and statistics. First we present a one-dimensional model which is essentially a random translation of pure heat equation. For some deterministic initial data, the ensuing scalar PDF and its statistical moments can be explicitly calculated. We use this model as a testbed for validating a numerical reconstruction procedure for the PDF via orthogonal polynomial expansion. In this model, the Peclet number is shown to be decisive in establishing the transition in the singularity structure of the PDF which affects the effectiveness of the series expansion, from only one algebraic singularity at unit scalar values (small Peclet), to two algebraic singularities at both unit and zero scalar values (large Peclet). Next, we study the more complicated, two-dimensional model in which the underlying flow is a random linear shear in one dimension. For planar, Gaussian random initial data, we identify the scalar PDF as an integral representing a conditional mixing of Gaussian probability measures averaged over all realizations of a single random variable, namely, the renormalized L2-norm of standard Wiener process. Rigorous asymptotic analyses and solid numerical simulation are performed to the integral formulation to study the evolution and the parametric dependence of the scalar PDF. During these analyses, we discover a transient, nonmonotonic "breathing" phenomena that is related to the multiple spatial scales in the initial random field. Lastly, some preliminary analytical and numerical results are presented to explore the potential of applying the reconstruction methodology to more general, physically relevant models, such as a rotating, viscous, wind-driven shallow water equation.
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The 'ingredients' which control a phase transition in well defined systems as well as in random ones (e.q. random magnetic systems) are listed and discussed within a somehow unifying perspective. Among these 'ingredients' the couplings and elements responsible for the cooperative phenomenon, the topological connectivity as well as possible topological incompatibilities, the influence of new degrees of freedom, the order parameter dimensionality, the ground state degeneracy and finally the 'quanticity' of the system are found. The general trends, though illustrated in magnetic systems, essentially hold for all phase transitions, and give a basis for connection of this area with Field theory, Theory of dynamical systems, etc. (Author)
Eynard, Bertrand; Ribault, Sylvain
2015-01-01
We provide a self-contained introduction to random matrices. While some applications are mentioned, our main emphasis is on three different approaches to random matrix models: the Coulomb gas method and its interpretation in terms of algebraic geometry, loop equations and their solution using topological recursion, orthogonal polynomials and their relation with integrable systems. Each approach provides its own definition of the spectral curve, a geometric object which encodes all the properties of a model. We also introduce the two peripheral subjects of counting polygonal surfaces, and computing angular integrals.
On discrete stochastic processes with long-lasting time dependence
Queiros, Silvio M Duarte
2008-01-01
In this manuscript, we study, both analytically and numerically, statistical properties of an heteroskedastic process based on the celebrated ARCH generator of random variables whose variance is defined by memory of $q_{m}$-exponencial, form ($e_{q_{m}=1}^{x}=e^{x}$). Specifically, we inspect the form of the self-correlation function of squared random variables and of the kurtosis. In addition, we infer, by numerical procedures, the stationary probability density functions of random variables and variance, multiscaling properties, first-passage times distribution, and the dependence degree. Last of all, we introduce an asymmetric variance version that enable us to reproduce the so-called leverage effect in financial markets.
Understanding copula transforms: a review of dependence properties
Michiels F.; De Schepper A.
2009-01-01
A copula is a flexible modeling tool which contributes substantially to the study of dependencies among random variables. A broad copula class with many nice properties is the Archimedean copula class. Usually, one works with the classical bivariate models, e.g. as summarized in Nelsen (2006), which are one-parametric models. However, in many cases when practitioners want to model dependencies by means of copulas, it would be more rational to work with multi-parametric models. Indeed, multi-p...
International Nuclear Information System (INIS)
The goal of random dynamics is the derivation of the laws of Nature as we know them (standard model) from inessential assumptions. The inessential assumptions made here are expressed as sets of general models at extremely high energies: gauge glass and spacetime foam. Both sets of models lead tentatively to the standard model. (orig.)
Barra, Orazio A
2013-01-01
Although HRV (Heart Rate Variability) analyses have been carried out for several decades, several limiting factors still make these analyses useless from a clinical point of view. The present paper aims at overcoming some of these limits by introducing the "Life Potential" (BMP), a new mathematical algorithm which seems to exhibit surprising cognitive and predictive capabilities. BMP is defined as a linear combination of five HRV Non-Linear Variables, in turn derived from the thermodynamic formalism of chaotic dynamic systems. The paper presents experimental measurements of BMP (Average Values and Standard Deviations) derived from 1048 Holter tests, matched in age and gender, including a control group of 356 healthy subjects. The main results are: (a) BMP always decreases when the age increases, and its dependence on age and gender is well established; (b) the shape of the age dependence within "healthy people" is different from that found in the general group: this behavior provides evidence of possible illn...
Messaro. Semma; Harrison, Phillip
2010-01-01
Ares I Zonal Random vibration environments due to acoustic impingement and combustion processes are develop for liftoff, ascent and reentry. Random Vibration test criteria for Ares I Upper Stage pyrotechnic components are developed by enveloping the applicable zonal environments where each component is located. Random vibration tests will be conducted to assure that these components will survive and function appropriately after exposure to the expected vibration environments. Methodology: Random Vibration test criteria for Ares I Upper Stage pyrotechnic components were desired that would envelope all the applicable environments where each component was located. Applicable Ares I Vehicle drawings and design information needed to be assessed to determine the location(s) for each component on the Ares I Upper Stage. Design and test criteria needed to be developed by plotting and enveloping the applicable environments using Microsoft Excel Spreadsheet Software and documenting them in a report Using Microsoft Word Processing Software. Conclusion: Random vibration liftoff, ascent, and green run design & test criteria for the Upper Stage Pyrotechnic Components were developed by using Microsoft Excel to envelope zonal environments applicable to each component. Results were transferred from Excel into a report using Microsoft Word. After the report is reviewed and edited by my mentor it will be submitted for publication as an attachment to a memorandum. Pyrotechnic component designers will extract criteria from my report for incorporation into the design and test specifications for components. Eventually the hardware will be tested to the environments I developed to assure that the components will survive and function appropriately after exposure to the expected vibration environments.
Marta Makara-Studzińska; Agnieszka J. Kowalska; Danuta Podstawka; Aneta Pyłypczuk; Zbigniew Śliwiński
2013-01-01
Introduction: The level of life quality of people with alcohol dependence is significantly influenced by socio-demographic factors such as: gender, marital status and having a family. Additionally promoting anti-health behaviors such as smoking or using psychoactive substances among those with alcohol dependence also reduces the quality of life in this population. Aim of the research: The purpose of this project was to determine the impact of selected psycho-social and medical factors ...
Relative Complexity of random walks in random sceneries
Aaronson, Jon
2010-01-01
Relative complexity measures the complexity of a probability preserving transformation relative to a factor being a sequence of random variables whose exponential growth rate is the relative entropy of the extension. We prove distributional limit theorems for the relative complexity of certain zero entropy extensions: RWRSs whose associated random walks satisfy the alpha-stable CLT (alpha>1). The results give invariants for relative isomorphism of these.