WorldWideScience

Sample records for denied basic human

  1. Human Memory: The Basics

    Science.gov (United States)

    Martinez, Michael E.

    2010-01-01

    The human mind has two types of memory: short-term and long-term. In all types of learning, it is best to use that structure rather than to fight against it. One way to do that is to ensure that learners can fit new information into patterns that can be stored in and more easily retrieved from long-term memory.

  2. Human Memory: The Basics

    Science.gov (United States)

    Martinez, Michael E.

    2010-01-01

    The human mind has two types of memory: short-term and long-term. In all types of learning, it is best to use that structure rather than to fight against it. One way to do that is to ensure that learners can fit new information into patterns that can be stored in and more easily retrieved from long-term memory.

  3. Denied pregnancy.

    Science.gov (United States)

    Habek, Dubravko

    2010-06-01

    Two cases of non-psychotic denied pregnancy are presented and discussed. Following obstetric expertise, the forensic-criminal evaluation should investigate the reported crimes of denied pregnancy associated infanticide or criminal abortion as well as the potential involvement of other persons in these crimes. All this would require close collaboration between obstetricians, psychiatrists and crime investigation experts in the forensic expertise of these criminal offences.

  4. [Basic disorders in human communication].

    Science.gov (United States)

    Peñaloza-López, Y; Gutiérrez-Silva, J; Andrade-Illañez, E N; Fierro-Evans, M A; Hernández-López, X

    1989-01-01

    This paper specifies the areas and disorders that concern human communication medicine. The frequency of the diverse disorders is analyzed in relation to age and sex, and the distribution in group ages of several disabling diseases is also discussed.

  5. Denis Guedj at CERN

    CERN Multimedia

    2009-01-01

    Denis Guedj (right), pictured with Etiennette Auffray Hillemanns of the CMS collaboration and Hartmut Hillemanns of the DG-KTT group.French author Denis Guedj, who is also a mathematician and Professor of History of Science at Paris VIII University, visited CERN on 7 and 8 October. During a presentation in the CERN Library he discussed his 15 published books and likened the process of novel writing to working on a scientific experiment: it begins with a limited amount of data, and then questions arise, problems are solved and further research reveals truths. Denis Guedj works hard to ensure that his novels contain ‘true fiction’. His most recent visit to CERN will help him to write a new book set at the LHC in which he will combine his scientific interest in what happens when a proton and proton collide with a human story about what happens to a male and female physicist who meet in the LHC tunnel. "Visiting the CMS cavern was...

  6. Basics of teaching Latin at Humanities University

    Directory of Open Access Journals (Sweden)

    Bragova Arina Mikhailovna

    2017-04-01

    Full Text Available The article reviews the goals, tasks, methods, and results of teaching Latin at Humanities University. The article points out that the basis of teaching is analytical reading with elements of discursive analysis. In Humanities University teaching is being provided through the interdisciplinary approach. The educational process includes interactive exercises, the use various forms of control, for example, lingual-didactic testing in a virtual learning environment. The results of current and final control are formed with the help of the point-rating system of assessing knowledge.

  7. ABOUT THE BASICS OF HUMAN THINKING APPARATUS

    Directory of Open Access Journals (Sweden)

    Yuriy Mikhailovich AMIRBEGOV

    2015-01-01

    Full Text Available The main subject of our research is the integrity of the thinking apparatus of humans with its extremes, one of which is known to us as cause-effect materiality, denoted by the term ―brain‖, and the other extreme is unknown but is supposed as an immaterial cause of the motion needed to ―revitalize‖ the material extreme in response to revitalizing effects, reacting with changes the order and direction of which are realized by light streams (oscillation spectrum in the range of light waves and sounds of different tones (oscillation spectrum in the range of sound waves. But for realization of light streams and sound streams into images and words is needed not only information streams regulator (dominant factor, changing their vectors in the integrity of the human thinking apparatus, but also verifier of oscillations is needed which requires philosophical comprehension.While modeling the thinking apparatus of humans by dialectical method of reasoning, we had to abandon the conventional opinions about reality, matter, motion, and take on trust the opinions which have not been confirmed but are logically essential – a divine spark of Aristotle and permanent impacts taking the material world out of a cold death…, what led to the solution of the problem: as a result was found the second, immaterial extreme of the integrity of human thinking apparatus and the dominant factor focusing the flow of information in the CNS and having the significance of the status of the monarch. Actually, the proposed model of human thinking apparatus, which has no analogue, presents the novelty of the worldview which answers the question: what is thinking, why and how, and what is realized by us, our mortal body and immortal soul identifying our ―I‖.

  8. Denis Gudet (1955-2010)

    CERN Multimedia

    Human Resources Department

    2010-01-01

    We deeply regret to announce the death of Mr Denis GUDET on 04.11.2010. Mr Denis GUDET, born on 14.03.1955, worked in the EN Department and had been employed at CERN since 01.05.1981. The Director-General has sent his family a message of condolence on behalf of the CERN staff. Social Affairs

  9. Adult Education, Basic Human Needs, and Integrated Development Planning

    Science.gov (United States)

    Green, Reginald Herbold

    1976-01-01

    This paper argues for an integrated approach to adult education which would require an examination of basic human needs and national development planning each in its own terms. The paper's argument is centered on liberation and participation as ends, not means: Education, development, and planning must be seen and acted on as an integrated whole.…

  10. Basic Science Research and the Protection of Human Research Participants

    Science.gov (United States)

    Eiseman, Elisa

    2001-03-01

    Technological advances in basic biological research have been instrumental in recent biomedical discoveries, such as in the understanding and treatment of cancer, HIV/AIDS, and heart disease. However, many of these advances also raise several new ethical challenges. For example, genetic research may pose no physical risk beyond that of obtaining the initial blood sample, yet it can pose significant psychological and economic risks to research participants, such as stigmatization, discrimination in insurance and employment, invasion of privacy, or breach of confidentiality. These harms may occur even when investigators do not directly interact with the person whose DNA they are studying. Moreover, this type of basic research also raises broader questions, such as what is the definition of a human subject, and what kinds of expertise do Institutional Review Boards (IRBs) need to review the increasingly diverse types of research made possible by these advances in technology. The National Bioethics Advisory Commission (NBAC), a presidentially appointed federal advisory committee, has addressed these and other ethical, scientific and policy issues that arise in basic science research involving human participants. Two of its six reports, in particular, have proposed recommendations in this regard. "Research Involving Human Biological Materials: Ethical and Policy Guidance" addresses the basic research use of human tissues, cells and DNA and the protection of human participants in this type of research. In "Ethical and Policy Issues in the Oversight of Human Research" NBAC proposes a definition of research involving human participants that would apply to all scientific disciplines, including physical, biological, and social sciences, as well as the humanities and related professions, such as business and law. Both of these reports make it clear that the protection of research participants is key to conducting ethically sound research. By ensuring that all participants in

  11. Health as a basic human need: would this be enough?

    Science.gov (United States)

    de Campos, Thana Cristina

    2012-01-01

    Although the value of health is universally agreed upon, its definition is not. Both the WHO and the UN define health in terms of well-being. They advocate a globally shared responsibility that all of us - states, international organizations, pharmaceutical corporations, civil society, and individuals - bear for the health (that is, the well-being) of the world's population. In this paper I argue that this current well-being conception of health is troublesome. Its problem resides precisely in the fact that the well-being conception of health, as an all-encompassing label, does not properly distinguish between the different realities of health and the different demands of justice, which arise in each case. In addressing responsibilities related to the right to health, we need to work with a more differentiated vocabulary, which can account for these different realities. A crucial distinction to bear in mind, for the purposes of moral deliberation and the crafting of political and legal institutions, is the difference between basic and non-basic health needs. This distinction is crucial because we have presumably more stringent obligations and rights in relation to human needs that are basic, as they justify stronger moral claims, than those grounded on non-basic human needs. It is important to keep this moral distinction in mind because many of the world's problems regarding the right to health relate to basic health needs. By conflating these needs with less essential ones, we risk confusing different types of moral claims and weakening the overall case for establishing duties regarding the right to health. There is, therefore, a practical need to reevaluate the current normative conception of health so that it distinguishes, within the broad scope of well-being, between what is basic and what is not. My aim here is to shed light onto this distinction and to show the need for this differentiation. I do so, first, by providing, on the basis of David Miller

  12. Nursing and justice as a basic human need.

    Science.gov (United States)

    Johnstone, Megan-Jane

    2011-01-01

    This paper explores the idea that justice is a basic human need akin to those famously depicted in Maslow's hierarchy of human needs and, as such, warrants recognition as a core element in representative ideas about nursing. Early nurse theorists positioned the principles and practice of nursing as having their origins in 'universal human needs'. The principle of deriving nursing care from human needs was thought to provide a guide not only for promoting health, but for preventing disease and illness. The nursing profession has had a longstanding commitment to social justice as a core professional value and ideal, obligating nurses to address the social conditions that undermine people's health. The idea of justice as a universal human need per se and its possible relationship to people's health outcomes has, however, not been considered. One reason for this is that justice in nursing discourse has more commonly been associated with law and ethics, and the legal and ethical responsibilities of nurses in relation to individualized patient care and, more recently, changing systems of care to improve health and health outcomes. Although this association is not incorrect, it is incomplete. A key aim of this paper is to redress this oversight and to encourage a broader conceptualization of justice as necessary for human survival, health and development, not merely as a professional value, or legal or ethical principle for guiding human conduct. © 2010 Blackwell Publishing Ltd.

  13. Meta-basic estimates the size of druggable human genome.

    Science.gov (United States)

    Plewczynski, Dariusz; Rychlewski, Leszek

    2009-06-01

    We present here the estimation of the upper limit of the number of molecular targets in the human genome that represent an opportunity for further therapeutic treatment. We select around approximately 6300 human proteins that are similar to sequences of known protein targets collected from DrugBank database. Our bioinformatics study estimates the size of 'druggable' human genome to be around 20% of human proteome, i.e. the number of the possible protein targets for small-molecule drug design in medicinal chemistry. We do not take into account any toxicity prediction, the three-dimensional characteristics of the active site in the predicted 'druggable' protein families, or detailed chemical analysis of known inhibitors/drugs. Instead we rely on remote homology detection method Meta-BASIC, which is based on sequence and structural similarity. The prepared dataset of all predicted protein targets from human genome presents the unique opportunity for developing and benchmarking various in silico chemo/bio-informatics methods in the context of the virtual high throughput screening.

  14. S-Denying a Theory

    Directory of Open Access Journals (Sweden)

    Smaradache F.

    2011-01-01

    Full Text Available In this paper we introduce the operators of validation and invalidation of a proposition, and we extend the operator of S-denying a proposition, or an axiomatic system, from the geometric space to respectively any theory in any domain of knowledge, and show six examples in geometry, in mathematical analysis, and in topology.

  15. Highway Companies Deny Windfall Profits

    Institute of Scientific and Technical Information of China (English)

    Securities Daily

    2011-01-01

    @@ There is no denying that the real estate industry sees huge profits, but it is hard to imag-ine that the gross profits of highway companies have reached a very high level, becoming another typical industry of huge profits.The sky-high road toll is attracting more and more public concerns about the seemingly low-profile and stable industry.

  16. [Work as a basic human need and health promoting factor].

    Science.gov (United States)

    Bertazzi, P A

    2010-01-01

    The Italian Constitution (1948) defines 'work' as the founding value of the Italian Republic. This choice was not motivated by mere economic reasons, but rather stemmed from the recognition that work is the most appropriate tool for the expression of the human personality in society, that it is an asset and a right that will increase the dignity of every person, and which corresponds to a fundamental human desire to fulfil oneself in relationship with other persons and the entire world This view of work, including its technical and manual aspects, was unknown to the ancient mentality and became familiar to us through the monastic orders of the early middle ages, which began to conceive and practise human work as a means of participating in the work of creation and transmitted this value over the centuries. As we experience today, if occupation is lacking, a basic condition for the development of the person and for his/her contribution to the growth of society is lost. Given the meaning of work in human experience, it is not surprising that unemployment represents not only a worrisome economic indicator, but also the cause of ill health. At the end of 2009 unemployment in the European Union reached 10%, similar to the rate in the US; in Italy it was estimated at 8.5% in December 2009 and is expected to reach 10% in 2010. In Lombardy, although employment had been constantly increasing between 1995 and 2008, and the current unemployment rate is as low as 4.9%, 100,000 jobs were lost in 2009. Several scientific papers have demonstrated the association between lack of occupation and lack of physical and mental health. In the present period of crisis, increases of 30% in cases of anxiety syndrome and of 15% in cases of depression have been reported. An increase in suicides among unemployed persons has been documented in several countries even if there are still problems of interpretation of the causal chain of events. Mortality among the unemployed increased, not only

  17. 5 CFR 1205.15 - Denying access.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Denying access. 1205.15 Section 1205.15... Procedures for Obtaining Records § 1205.15 Denying access. (a) Basis. In accordance with 5 U.S.C. 552a(k)(2), the Board may deny access to records that are of an investigatory nature and that are compiled for...

  18. 31 CFR 500.573 - Certain donations of funds and goods to meet basic human needs authorized.

    Science.gov (United States)

    2010-07-01

    ... to meet basic human needs authorized. 500.573 Section 500.573 Money and Finance: Treasury Regulations... Certain donations of funds and goods to meet basic human needs authorized. (a) The donation of funds for... meet basic human needs are authorized. For purposes of this section, goods to meet basic human needs...

  19. Galaxies and Cosmology with DENIS

    CERN Document Server

    Mamon, G A; Bonin, W; Banchet, V

    1997-01-01

    The DENIS survey is currently imaging 21334 deg^2 of the mainly southern sky in the IJK and the observations are expected to go on until mid 2000. The expectations for extragalactic and cosmological research are outlined, including a quantitative assessment of the effects of recent star formation on the measured fluxes of galaxies. The galaxy extraction is much improved with the modeling of the PSF across the 12'x12' frames and the reliability of star/galaxy separation (currently based upon a combination of classical and neural-network based methods) is measured from visual inspection to be >90% at I = 16. The I band counts follow the high bright-end normalization and the J differential counts follow N(J) \\simeq 11 \\times dex [0.6 (J-14)] deg^{-2} mag^{-1} and are expected to be complete, reliable and photometrically accurate

  20. Impact of Rural Basic Human Capital Investment on Regional Development Ability

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    From the perspective of human resources development and regional economic cooperation,this paper expounds the basic conditions for socio-economic transformation and development in underdeveloped rural areas,and the ways to acquire basic human capital.On the basis of this,this paper further analyses the regional competitiveness difference arising from human capital difference,and proposes that we should solve this problem through sufficient supply of rural compulsory education.

  1. 77 FR 34340 - Order Denying Export Privileges

    Science.gov (United States)

    2012-06-11

    ... Enforcement, including its Director, and the facts available to BIS, I have decided to deny Chitron-US's... use of Chitron-US, as a front company, and Chitron-HK, as a transit point, to funnel goods to...

  2. Purification and Refolding of Overexpressed Human Basic Fibroblast Growth Factor in Escherichia coli

    OpenAIRE

    2011-01-01

    International audience; This work describes the integration of expanded bed adsorption (EBA) and adsorptive protein refolding operations used to recover purified and biologically active human basic fibroblast growth factor from inclusion bodies expressed in E. coli. Insoluble overexpressed human basic fibroblast growth factor has been purified on CM Hyper Z matrix by expanded bed adsorption after isolation and solubilization in 8 M urea. The adsorption was made in expanded bed without clarifi...

  3. Pathobiology of human cerebrovascular malformations: basic mechanisms and clinical relevance.

    Science.gov (United States)

    Gault, Judith; Sarin, Hemant; Awadallah, Nabil A; Shenkar, Robert; Awad, Issam A

    2004-07-01

    Cerebrovascular malformations affect more than 3% of the population, exposing them to a lifetime risk of hemorrhagic stroke, seizures, and focal neurological deficits. Cerebral cavernous malformations (CCMs) exhibit an immature vessel wall, a brittle hemorrhagic tendency, and epileptogenesis, whereas arteriovenous malformations (AVMs) lack capillary beds and manifest apoplectic bleeding under high-flow conditions. There are also more benign venous anomalies, capillary malformations, and lesions with mixed and transitional features. Advances have been made toward understanding the natural history, radiological and pathological correlates, and clinical management. Yet, mechanisms of lesion genesis and clinical manifestations remain largely unknown, and the clinical behavior in individual patients is highly unpredictable. Lesion pathogenesis likely involves abnormal assembly or maintenance of blood vessels, resulting in dysmorphic vessel phenotypes. Familial CCM disease is in part caused by mutations in a cytoskeletal-related protein that is likely integral to interendothelial cell connectivity and maturation of the vascular wall. Rare familial forms of AVM disease have been correlated with two different transforming growth factor-beta receptor components, possibly causing disturbance in signaling during vascular assembly. Relevance of these mechanisms to the more common and otherwise identical sporadic CCM and AVM lesions is being explored. In this report, basic mechanisms of vasculogenesis and angiogenesis and how they possibly relate to the common cerebrovascular malformation lesions are reviewed. Novel concepts are discussed related to the cellular, molecular, and genetic substrates in CCM and AVM as well as to how this knowledge can be applied to predict, explain, and possibly modify clinical disease manifestations.

  4. Recombinant human thrombopoietin: basic biology and evaluation of clinical studies.

    Science.gov (United States)

    Kuter, David J; Begley, C Glenn

    2002-11-15

    Thrombocytopenia is a common medical problem for which the main treatment is platelet transfusion. Given the increasing use of platelets and the declining donor population, identification of a safe and effective platelet growth factor could improve the management of thrombocytopenia. Thrombopoietin (TPO), the c-Mpl ligand, is the primary physiologic regulator of megakaryocyte and platelet development. Since the purification of TPO in 1994, 2 recombinant forms of the c-Mpl ligand--recombinant human thrombopoietin (rhTPO) and pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF)--have undergone extensive clinical investigation. Both have been shown to be potent stimulators of megakaryocyte growth and platelet production and are biologically active in reducing the thrombocytopenia of nonmyeloablative chemotherapy. However, neither TPO has demonstrated benefit in stem cell transplantation or leukemia chemotherapy. Other clinical studies have investigated the use of TPO in treating chronic nonchemotherapy-induced thrombocytopenia associated with myelodysplastic syndromes, idiopathic thrombocytopenic purpura, thrombocytopenia due to human immunodeficiency virus, and liver disease. Based solely on animal studies, TPO may be effective in reducing surgical thrombocytopenia and bleeding, ex vivo expansion of pluripotent stem cells, and as a radioprotectant. Ongoing and future studies will help define the clinical role of recombinant TPO and TPO mimetics in the treatment of chemotherapy- and nonchemotherapy-induced thrombocytopenia.

  5. An empirical assessment of generational differences in basic human values.

    Science.gov (United States)

    Lyons, Sean T; Duxbury, Linda; Higgins, Christopher

    2007-10-01

    This study assessed generational differences in human values as measured by the Schwartz Value Survey. It was proposed that the two most recent generations, Millennials and Generation Xers, would value Self-enhancement and Openness to Change more than the two older generations, Baby Boomers and Matures, while the two older generations would value Self-transcendence and Conservation more. The hypotheses were tested with a combined sample of Canadian knowledge workers and undergraduate business students (N = 1,194). Two hypotheses were largely supported, although an unexpectedly large difference was observed between Millennials and Generation Xers with respect to Openness to Change and Self-enhancement. The findings suggest that generation is a useful variable in examining differences in social values.

  6. How Does Air Pollution Threaten Basic Human Rights? The Case Study of Bulgaria

    Science.gov (United States)

    Ahmedova, Aylin Hasanova

    2016-01-01

    The main purpose of this article is to analyze the relationship between air pollution and human rights. It investigates whether air pollution threatens basic human rights such as the right to health, life, and the environment. Air pollution represents a major threat both to health and to the environment. Despite the adoption of numerous…

  7. Purification and Refolding of Overexpressed Human Basic Fibroblast Growth Factor in Escherichia coli

    Directory of Open Access Journals (Sweden)

    Mona Alibolandi

    2011-01-01

    Full Text Available This work describes the integration of expanded bed adsorption (EBA and adsorptive protein refolding operations used to recover purified and biologically active human basic fibroblast growth factor from inclusion bodies expressed in E. coli. Insoluble overexpressed human basic fibroblast growth factor has been purified on CM Hyper Z matrix by expanded bed adsorption after isolation and solubilization in 8 M urea. The adsorption was made in expanded bed without clarification steps such as centrifugation. Column refolding was done by elimination of urea and elution with NaCl. The human basic fibroblast growth factor was obtained as a highly purified soluble monomer form with similar behavior in circular dichroism and fluorescence spectroscopy as native protein. A total of 92.52% of the available human basic fibroblast growth factor was recovered as biologically active and purified protein using the mentioned purification and refolding process. This resulted in the first procedure describing high-throughput purification and refolding of human basic fibroblast growth factor in one step and is likely to have the greatest benefit for proteins that tend to aggregate when refolded by dilution.

  8. THE BASIC OBJECTIVES OF DEMECRACY  AND FUNDAMENTAL INTERNATIONAL AGREEMENTS  FOR THE PROTECTION OF HUMAN RIGHTS

    OpenAIRE

    ILGAZ , Dr.Nesrin DEMİR  Assist.Prof.Dr.Deniz

    2007-01-01

    The basic objectives of democracy, as they take place openly in the definition of the concept and are lead primarily by freedom and equality, are listed as political representation, political participation and rights. The first important document created in the international arena concerning human rights is the Universal Declaration on Human Rights, an instrument of the United Nations. A regional agreement which has great significance is the European Convention on Human Rights and Fundamental...

  9. Noggin versus basic fibroblast growth factor on the differentiation of human embryonic stem cells*

    Institute of Scientific and Technical Information of China (English)

    Yan Zhang; Junmei Zhou; Zhenfu Fang; Manxi Jiang; Xuejin Chen

    2013-01-01

    The difference between Noggin and basic fibroblast growth factor for the neural precursor differen-tiation from human embryonic stem cel s has not been studied. In this study, 100 µg/L Noggin or 20 µg/L basic fibroblast growth factor in serum-free neural induction medium was used to differen-tiate human embryonic stem cel s H14 into neural precursors using monolayer differentiation. Two weeks after induction, significantly higher numbers of neural rosettes formed in the Noggin-induced group than the basic fibroblast growth factor-induced group, as detected by phase contrast micro-scope. Immunofluorescence staining revealed expression levels of Nestin,β-III Tubulin and Sox-1 were higher in the induced cel s and reverse-transcription PCR showed induced cel s expressed Nestin, Sox-1 and Neurofilament mRNA. Protein and mRNA expression in the Noggin-induced group was increased compared with the basic fibroblast growth factor-induced group. Noggin has a greater effect than basic fibroblast growth factor on the induction of human embryonic stem cel differentiation into neural precursors by monolayer differentiation, as Noggin accelerates and in-creases the differentiation of neural precursors.

  10. The DENIS & 2MASS Near Infrared Surveys

    CERN Document Server

    Mamon, G A

    1996-01-01

    The DENIS and 2MASS near infrared surveys are presented. Their applications in extragalactic astronomy and cosmology are listed. The prospects for a rapid spectroscopic followup survey of a near infrared selected sample of nearly $10^5$ galaxies are illustrated with Monte-Carlo simulations.

  11. 77 FR 72322 - Order Denying Export Privileges

    Science.gov (United States)

    2012-12-05

    ... Bureau of Industry and Security Order Denying Export Privileges In the Matter of: Kue Sang Chun... convicted of violating Section 38 of the Arms Export Control Act (22 U.S.C. 2778 (2000)) (``AECA''). Specifically, Chun was convicted of knowingly exporting and causing the export from the United States to...

  12. 78 FR 61953 - Order Denying Export Privileges

    Science.gov (United States)

    2013-10-08

    ... Bureau of Industry and Security Order Denying Export Privileges In the Matter of: Timothy Gormley, Inmate... engaging in transactions relating to exporting amplifiers to China and India without obtaining the required... assessment and a $1,000 criminal fine. Section 766.25 of the Export Administration Regulations (``EAR''...

  13. 78 FR 37520 - Order Denying Export Privileges

    Science.gov (United States)

    2013-06-21

    ... Bureau of Industry and Security Order Denying Export Privileges In the Matter of: Placido Molina, Jr... convicted of violating Section 38 of the Arms Export Control Act (22 U.S.C. 2778 (2006 & Supp. IV 2010)) (``AECA''). Specifically, Molina was convicted of knowingly and willfully attempting to export and...

  14. 78 FR 60248 - Order Denying Export Privileges

    Science.gov (United States)

    2013-10-01

    ... Bureau of Industry and Security Order Denying Export Privileges In the Matter of: Volha Dubouskaya... States, that is, to willfully export from the United States to Belarus export-controlled items, including... of $100.00. Section 766.25 of the Export Administration Regulations (``EAR'' or ``Regulations'')...

  15. 78 FR 60250 - Order Denying Export Privileges

    Science.gov (United States)

    2013-10-01

    ... Bureau of Industry and Security Order Denying Export Privileges In the Matter of: Vikramaditya Singh, a.k... attempting to cause the export of digital microwave radios to Iran without the required authorization from... probation, six months of home confinement and a $100,000 fine. Section 766.25 of the Export...

  16. 78 FR 37518 - Order Denying Export Privileges

    Science.gov (United States)

    2013-06-21

    ... Bureau of Industry and Security Order Denying Export Privileges In the Matter of: Lee Roy Perez, Inmate... convicted of violating Section 38 of the Arms Export Control Act (22 U.S.C. 2778 (2006 & Supp. IV 2010)) (``AECA''). ] Specifically, Perez was convicted of knowingly and willfully exporting and causing to...

  17. 78 FR 58995 - Order Denying Export Privileges

    Science.gov (United States)

    2013-09-25

    ... Bureau of Industry and Security Order Denying Export Privileges In the Matter of: Iman Kazerani, 153... was convicted of knowingly and willfully exporting and causing the exportation of laptop computers..., a $10,000 criminal fine and an assessment of $100. Section 766.25 of the Export...

  18. 78 FR 37785 - Order Denying Export Privileges

    Science.gov (United States)

    2013-06-24

    ... Bureau of Industry and Security Order Denying Export Privileges In the Matter of: Gerardo Domingo... Domingo Rodriguez-Rivera (``Rodriguez-Rivera'') was convicted of violating Section 38 of the ] Arms Export... convicted of knowingly and willfully exporting and causing to be exported and attempting to export...

  19. 78 FR 60249 - Order Denying Export Privileges

    Science.gov (United States)

    2013-10-01

    ... Bureau of Industry and Security Order Denying Export Privileges In the Matter of: Andrew Silcox, Inmate... of violating Section 38 of the Arms Export Control Act (22 U.S.C. 2778 (2006 & Supp. IV 2010)) (``AECA''). Specifically, Silcox was convicted of knowingly and willfully exporting from the United...

  20. 77 FR 60379 - Order Denying Export Privileges

    Science.gov (United States)

    2012-10-03

    ... Bureau of Industry and Security Order Denying Export Privileges In the Matter of: Phillip Andro Jamison..., 2011, in the U.S. District Court, Southern District of California, Phillip Andro Jamison (``Jamison.... Until November 4, 2021, Phillip Andro Jamison, with last known addresses at: currently incarcerated...

  1. Autocrine growth regulation of human glomerular mesangial cells is primarily mediated by basic fibroblast growth factor.

    OpenAIRE

    Francki, A.; Uciechowski, P.; Floege, J; von der Ohe, J.; Resch, K.; Radeke, H. H.

    1995-01-01

    For various forms of human glomerulonephritis a close relationship between inflammatory injury and a local mesangial proliferative response has been described. Herein, we used primary cultures of human glomerular mesangial cells (HMCs) from five different donors to determine the autocrine growth-inducing capacity of their supernatants after stimulation with different cytokines and lipopolysaccharide (LPS) to determine whether this effect is due to basic fibroblast growth factor (bFGF). The ba...

  2. Deep near-infrared survey of the Southern Sky (DENIS)

    Science.gov (United States)

    Deul, E.

    1992-01-01

    DENIS (Deep Near-Infrared Survey of the Southern Sky) will be the first complete census of astronomical sources in the near-infrared spectral range. The challenges of this novel survey are both scientific and technical. Phenomena radiating in the near-infrared range from brown dwarfs to galaxies in the early stages of cosmological evolution, the scientific exploitation of data relevant over such a wide range requires pooling expertise from several of the leading European astronomical centers. The technical challenges of a project which will provide an order of magnitude more sources than given by the IRAS space mission, and which will involve advanced data-handling and image-processing techniques, likewise require pooling of hardware and software resources, as well as of human expertise. The DENIS project team is composed of some 40 scientists, computer specialists, and engineers located in 5 European Community countries (France, Germany, Italy, The Netherlands, and Spain), with important contributions from specialists in Australia, Brazil, Chile, and Hungary. DENIS will survey the entire southern sky in 3 colors, namely in the I band at a wavelength of 0.8 micron, in the 1.25 micron J band, and in the 2.15 micron K' band. The sensitivity limits will be 18th magnitude in the I band, 16th in the J band, and 14.5th in the K' band. The angular resolution achieved will be 1 arcsecond in the I band, and 3.0 arcseconds in the J and K' bands. The European Southern Observatory 1 m telescope on La Silla will be dedicated to survey use during operations expected to last four years, commencing in late 1993. DENIS aims to provide the astronomical community with complete digitized infrared images of the full southern sky and a catalogue of extracted objects, both of the best quality and in readily accessible form. This will be achieved through dedicated software packages and specialized catalogues, and with assistance from the Leiden and Paris Data Analysis Centers. The data

  3. Finitude and Death - certainties denied

    Directory of Open Access Journals (Sweden)

    Maria Helena Villas Bôas Concone

    2014-11-01

    Full Text Available The themes of this issue of the Journal Kairós Gerontology seemed determined to submit the publication to opposing pressures: on one side there were the several articles and article propositions sent by many authors and distinct approaches, demanding more than ever the effort of our collaborators in the evaluation process; on the other side there were our own difficulties (technical and personnel to take forward and quickly the task and the inevitable delays. If the influx of articles clearly showed the interest and the opportunity of the journal’s proposal, the unwillingly delays seemed to confirm the denial/avoidance face of the themes of finitude and death. Indeed, it seemed to us necessary the election of these themes for reflection for obvious reasons, especially when involved in a Masters in Gerontology: the more avoided the more the reflection is needed; in case of working or having a relationship (professional or personal with many elderly, people close to death, or people facing definitive diagnosis, the avoidance perhaps brings more suffering than benefit to the parts involved. The old saying “In home of hanged don’t talk about ropes” might have its justification, but common sense and touch is needed; it is not a “folk remedy”. It always seemed to me (I do not place myself out of it that most humans think they are immortal or at least non-mortal (an indeterminate human deviation, to the extent that death and dying are pushed deep to the unconsciousness only surfacing back to consciousness in extreme situations. Death can be thought intellectually, turned into subject of literary, religious or philosophical speculation; it also can be turned into subject of anthropological, sociological or other types of investigation; it can be thought in numbers supporting epidemiological questions and population analysis; focused in cuts of gender, class, age, ethnicity; specified in causes and causes connected to each of the cuts above

  4. DENIS Galaxies in the Zone of Avoidance

    CERN Document Server

    Schröder, A; Mamon, G A; Ruphy, S; Paris-Meudon, Obs.

    1997-01-01

    We investigated the potential of using DENIS for studies of galaxies behind the obscuration layer of our Milky Way, and mapping the Galactic extinction. As a pilot study, we examined DENIS I-, J-, and K-band images of heavily obscured galaxies from a deep optical (B_J-band) galaxy survey in the Zone of Avoidance. We tried to uncover additional galaxies at latitudes where the Milky Way remains fully opaque, i.e. we conducted a `blind' search at |b| 4-5 mag. Furthermore, we determined the I, J and K magnitudes of galaxies in the low-latitude, nearby, rich cluster Abell 3627 and compared the resulting colour-colour diagram with that of an unobscured cluster.

  5. Cloning, Expression and Functional Characterization of In-House Prepared Human Basic Fibroblast Growth Factor

    Directory of Open Access Journals (Sweden)

    Hassan Rassouli

    2013-01-01

    Full Text Available Objective: Human basic fibroblast growth factor (bFGF plays an important role in cellular proliferation, embryonic development, and angiogenesis as well as in several signaling pathways of various cell types. bFGF is an essential growth factor for the maintenance of undifferentiated human embryonic stem cells (hESCs and human induced pluripotent stem cells (hiPSCs.Materials and Methods: In this experimental study, we present a straightforward method to produce biologically active recombinant human bFGF protein in E. coli that has long-term storage ability.Results: This procedure provides a rapid, cost effective purification of a soluble human bFGF protein that is biologically active and functional as measured in hESCs and hiPSCs in vitro and in vivo.Conclusion: The results show no significant difference in function between our in-house produced and commercialized bFGF.

  6. Stability and biological activity evaluations of PEGylated human basic fibroblast growth factor

    OpenAIRE

    Hadadian, Shahin; Shamassebi, Dariush Norouzian; Mirzahoseini, Hasan; Shokrgozar, Mohamad Ali; Bouzari, Saeid; Sepahi, Mina

    2015-01-01

    Background: Human basic fibroblast growth factor (hBFGF) is a heparin-binding growth factor and stimulates the proliferation of a wide variety of cells and tissues causing survival properties and its stability and biological activity improvements have received much attention. Materials and Methods: In the present work, hBFGF produced by engineered Escherichia coli and purified by cation exchange and heparin affinity chromatography, was PEGylated under appropriate condition employing 10 kD pol...

  7. A Symbiosis of Islamic Principles and Basic Human Values on Work and Life

    Directory of Open Access Journals (Sweden)

    Rokis Rohaiza

    2014-07-01

    Full Text Available The article discusses some basic issues on work and life based on Islamic and non-religious principles. Work and life are inseparable facets of and for human existence. Work derives from the demands of life, and thus it becomes a responsibility for every individual person. The article attempts to relate some highlighted Qur’anic verses and Hadith with basic occupational values such as honesty, modesty and innovativeness, among others, at workplaces. In the end, it makes an effort to understand the working of the subconscious mind on work to make life worthwhile. The plan for this article is to lay emphasis that the presence of human beings, which includes their mind, energy and whatever they can offer in the forms of work, benefits all. In such a case, not only those humans may be seen as successful in fulfilling the work-needs, but also victorious in completing the life-demands as human beings. “Virtuous workplace” is the most ideal platform for such purpose.

  8. Denis Goulet and the project of development ethics : Choices in methodology, focus and organization

    NARCIS (Netherlands)

    D.R. Gasper (Des)

    2008-01-01

    textabstractDenis Goulet (1931-2006) was a pioneer of human development theory and the main founder of work on “development ethics” as a self-conscious field that, by his definition, treats the ethical and value questions posed by development theory, planning, and practice. The paper looks at

  9. Denis Goulet and the project of development ethics : Choices in methodology, focus and organization

    NARCIS (Netherlands)

    D.R. Gasper (Des)

    2008-01-01

    textabstractDenis Goulet (1931-2006) was a pioneer of human development theory and the main founder of work on “development ethics” as a self-conscious field that, by his definition, treats the ethical and value questions posed by development theory, planning, and practice. The paper looks at aspect

  10. [Basic human needs of nursing professional: situations of (dis)satisfaction at work].

    Science.gov (United States)

    Regis, Lorena Fagundes Ladeia Vitoria; Porto, Isaura Setenta

    2011-04-01

    Care is associated with the nursing actions considering, above all, a group of needs of the nursing team. The objectives of this study were: to characterize situations of (dis) satisfaction of the nursing team at work and analyze their possible implications. Maslow's theory of basic human needs was used to understand the motivational factors, and a qualitative methodology was used applying quantitative techniques. The method consisted of participant observation with registers on a filed diary associated to the application of a questionnaire on 18 participants from the nursing team of a Public Hospital in Rio de Janeiro. The study indicates that the basic needs of the nursing team are compromised, especially safety and physiological needs, which are the most primary. The compromising of the subjects' primary needs implies health hazards and reduced work performance in hospital settings.

  11. 14 CFR 250.5 - Amount of denied boarding compensation for passengers denied boarding involuntarily.

    Science.gov (United States)

    2010-01-01

    ... or reduced rate air transportation in lieu of the cash due under paragraph (a) of this section, if (1) the value of the transportation benefit offered is equal to or greater than the cash payment otherwise... passengers denied boarding involuntarily from an oversold flight at the rate of 200 percent of the...

  12. Human Induced Pluripotent Stem Cells from Basic Research to Potential Clinical Applications in Cancer

    Directory of Open Access Journals (Sweden)

    Teresa de Souza Fernandez

    2013-01-01

    Full Text Available The human induced pluripotent stem cells (hiPSCs are derived from a direct reprogramming of human somatic cells to a pluripotent stage through ectopic expression of specific transcription factors. These cells have two important properties, which are the self-renewal capacity and the ability to differentiate into any cell type of the human body. So, the discovery of hiPSCs opens new opportunities in biomedical sciences, since these cells may be useful for understanding the mechanisms of diseases in the production of new diseases models, in drug development/drug toxicity tests, gene therapies, and cell replacement therapies. However, the hiPSCs technology has limitations including the potential for the development of genetic and epigenetic abnormalities leading to tumorigenicity. Nowadays, basic research in the hiPSCs field has made progress in the application of new strategies with the aim to enable an efficient production of high-quality of hiPSCs for safety and efficacy, necessary to the future application for clinical practice. In this review, we show the recent advances in hiPSCs’ basic research and some potential clinical applications focusing on cancer. We also present the importance of the use of statistical methods to evaluate the possible validation for the hiPSCs for future therapeutic use toward personalized cell therapies.

  13. Denis Burkitt: A legacy of global health.

    Science.gov (United States)

    Esau, Daniel

    2016-09-28

    When first described in 1958, Burkitt lymphoma was considered by many to be an African curiosity. However, over the next few decades, over 10,000 publications on Burkitt lymphoma would influence many facets of oncology research including immunology, molecular genetics, chemotherapy, and viral oncology. At the time of discovery, its distribution in equatorial Africa was unique; it was where a child was born and lived, and not what race they were, that conveyed the greatest incidence risk. Its association with Epstein-Barr virus brought attention to the possibility that oncogenesis may be influenced by viruses. The influence that Burkitt lymphoma had on furthering oncology is far-reaching, and it is fitting that the physician credited with bringing attention to this disease was himself broad in his influence. Denis Burkitt was a humanitarian surgeon whose work was not limited to Burkitt lymphoma: he instigated a plan to rid an entire Ugandan district of yaws, he designed and created affordable orthopaedic equipment that could be locally produced in Kampala, and he was an early advocate of a high fiber diet. The following article will examine the biography of Denis Burkitt, with a focus on how he was able to further oncology and global health. © The Author(s) 2016.

  14. Movement as a basic concept in physiotherapy--a human science approach.

    Science.gov (United States)

    Wikström-Grotell, Camilla; Eriksson, Katie

    2012-08-01

    The development of scientific knowledge of physiotherapy (PT) has advanced significantly. Research is mostly conducted within a biomedical paradigm and theory-building is underpinned by a positivist paradigm. The basic philosophical questions and concepts are not much reflected on, and PT lacks an established theoretical frame. The first step in theory development is to define the basic concepts. The aim of this professional theoretical paper was to reflect on and describe the concept of movement in PT based on earlier research as a standpoint for a broader and deeper understanding of the complex nature of PT reality inspired by a model for concept analysis developed in caring science [Eriksson K 2010 Concept determination as part of the development of knowledge in caring science. Scandinavian Journal of Caring Sciences 24: 2-11]. The concept of movement in PT is conceptualized as complex and multidimensional. The understanding of human movement in PT is based on five categories described in the paper. The conceptualization of movement includes acting in relation to the socio-cultural environment, inter-dynamic aspects, as well as personal, intradynamic aspects. This paper argues for the need to further develop the concept of movement in PT within a human science approach. A deeper understanding is needed as a basis for understanding complex clinical practice as well as in shaping the PT discipline.

  15. DANGEROUS GAMES IN CARLOS DENIS MOLINA'S PLAYS

    OpenAIRE

    Braillon-Chantraine, Cécile

    2014-01-01

    International audience; De par son hyper réflexivité, l'oeuvre dramatique de l'écrivain uruguayen Carlos Denis Molina (1916-1983) constitue un témoignage des pratiques théâtrales de son époque et des mutations socio-économiques que traverse son pays, l'Uruguay, au cours du vingtième siècle. Le procédé méta théâtral du jeu, mettant en scène des personnages en train de se divertir et de jouer un rôle, est présent dans plusieurs de ses pièces, à chaque étape de sa production dramatique, et débou...

  16. Expression and Purification of Recombinant Human Basic Fibroblast Growth Factor Fusion Proteins and Their Uses in Human Stem Cell Culture.

    Science.gov (United States)

    Imsoonthornruksa, Sumeth; Pruksananonda, Kamthorn; Parnpai, Rangsun; Rungsiwiwut, Ruttachuk; Ketudat-Cairns, Mariena

    2015-01-01

    To reduce the cost of cytokines and growth factors in stem cell research, a simple method for the production of soluble and biological active human basic fibroblast growth factor (hbFGF) fusion protein in Escherichia coli was established. Under optimal conditions, approximately 60-80 mg of >95% pure hbFGF fusion proteins (Trx-6xHis-hbFGF and 6xHis-hbFGF) were obtained from 1 liter of culture broth. The purified hbFGF proteins, both with and without the fusion tags, were biologically active, which was confirmed by their ability to stimulate proliferation of NIH3T3 cells. The fusion proteins also have the ability to support several culture passages of undifferentiated human embryonic stem cells and induce pluripotent stem cells. This paper describes a low-cost and uncomplicated method for the production and purification of biologically active hbFGF fusion proteins.

  17. Defamation of Religions: A Vague and Overbroad Theory that Threatens Basic Human Rights

    Directory of Open Access Journals (Sweden)

    Allison G. Belnap

    2011-04-01

    Full Text Available Il contributo è pubblicato con il permesso della Brigham Young University Law Review - dove è apparso nel vol. n. 2 del 2010 (Tribute to Professor Michael Goldsmith, alle pp. 101-148 - e dell‖Autrice, che ringraziamo sentitamente.SUMMARY: 1. Introduction - 2. History of and Motivations for the OIC Defamation of Religions Resolutions - 2.a - The OIC Exerts a Concerted Effort to Protect Islam - 2.b - Terrorist Attacks and Danish Cartoons Raise the Stakes - 3. Defamation of Religions: A Permissible Restraint on Freedom of Speech and Expression? - 3.a - History, Basic Elements, and Contemporary Usage of Defamation - 3.b - Interaction Between Defamation of Religions and the Basic Human Rights Enumerated in Major International Instruments - 4. The Evolution of a Resolution - 4.a. 1999-2000: Beginnings - 4.b. 2001: A Pre-9/11 World - 4.c. 2002: Reactions to the Violent Backlash Against Muslims - 4.d. 2003-2004: Fluctuations in Support - 4.e. 2005: Intensification of a Campaign - 4.f. 2006-2007: The Move to the General Assembly - 4.g. 2008: Decreasing Margins of Support - 4.h. 2009: Current Resolution and Recommendations for Application - 5. Consequences of Accepting the Resolutions and Subsequent Enactment of Statutes Designed to Prevent Defamation of Religions - 5.a. Human Rights Committee - 5.b. The European Court of Human Rights - 5.c. Blasphemy, Incitement, and Hate Speech Laws and Their Enforcement - 5.d. Possible Future Statutes and Enforcement Under Defamation of Religions Theory - 6. Alternatives to Defamation of Religions in the U.N. Resolutions - 7. Conclusion.

  18. 42 CFR 403.316 - Reconsideration of certain denied applications.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false Reconsideration of certain denied applications. 403.316 Section 403.316 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND... Control Systems § 403.316 Reconsideration of certain denied applications. (a) Request for...

  19. Scientific Basics of Forming Human Quality and Perfection to Ensure Holistic Sustained Development

    Directory of Open Access Journals (Sweden)

    Nickolay Suvorov

    2015-02-01

    Full Text Available The general substance underlying the existence and development of the Universe and Man is energy. Energy is the unique and universal nature of all being. Everything is reduced to the amount and quality of energy. We were the first in the world to scientifically substantiate harmony as the universal criterion of the quality of energy of inner and outer interaction, optimality, perfection of energy-information images and systems of diverse nature. The harmony help solve the problem of forming high quality and perfection of human personality. Harmony is the key technology of creation, which God introduced when creating the Universe. The principles of harmony and holism are the basic components of Cosmo theory, the theory of development of the Universe and Man. In concentrated form, the theoretical studies dedicated to harmony and forming a new and perfect human being are presented in the book by NIKOLAI SUVOROV: "  − Perfect Man", International Publishers ERA, 2014, 300 pp. Embracing harmony creates conditions for sustained development-evolution of any human being, nation and civilisation as a whole. We believe that in the EU countries it would be practical to set up R&D and perfection training centres for studying and practically applying harmony. Key words: Harmony, quality, perfection.

  20. Basic Fibroblast Growth Factor and Fibroblast Growth Factor Receptor-1in Human Meningiomas

    Institute of Scientific and Technical Information of China (English)

    YI Wei; CHEN Jian; Filimon H. Golwa; XUE Delin

    2005-01-01

    The expression of basic fibroblast growth factor (bFGF) and fibroblast growth factor receptor-1 (FGFR-1) in human meningiomas and the relationships between their expression and the tumors' histological features and angiogenesis were investigated by means of immunohistochemical technique. The expression of bFGF and FGFR-1 was detected by antibody of bFGF or FGFR-1.The tumors' angiogenesis was evaluated by microvascular density (MVD) and, which was observed by use of CD34-antibody immunohistochemically. The results showed that there were varied degrees of the expression of bFGF and FGFR-1 proteins in meningiomas. The expression was correlated with the tumors' histological characters and angiogenesis. It was concluded that bFGF and FGFR-1 might play important roles in meningiomas' angiogenesis and proliferation. The expression positive rate of bFGF and FGFR-1 may provide an indication of evaluating the histological and malignant degree of the tumor.

  1. Improved haplotype analysis of human myelin basic protein short tandem repeat loci.

    Science.gov (United States)

    Watanabe, G; Umetsu, K; Yuasa, I; Suzuki, T

    2000-06-01

    We report an improved haplotype analysis of the human myelin basic protein gene (MBP) short tandem repeat (STR) polymorphism. The polymorphic G-->A transition and 2 conventional STR polymorphisms, MBPA and MBPB, were simultaneously determined by an amplified product length polymorphism technique. After the MBPC fragments containing MBPA and MBPB were amplified, the linkage of these 2 STR loci was determined by a second amplification, using polymerase chain reaction (PCR) technique, of the isolated MBPC fragments. The present haplotype analysis dispensed with family studies for the haplotyping of MBPA and MBPB. Polymorphisms of the MBP loci studied in German and Japanese populations showed a high genomic variation. Haplotype analysis of the MBP loci showed distinct differences between the German and the Japanese populations. Consequently, haplotype analysis of the MBP loci promises to be useful in forensic identification and paternity testing.

  2. Effect of recombinant human basic fibroblast growth factor on angiogenesis during mandible fracture healing in rabbits

    Institute of Scientific and Technical Information of China (English)

    龚振宇; 周树夏; 顾晓明; 李涤尘; 孙明林

    2003-01-01

    Objective: To investigate the effect of recombinant human basic fibroblast growth factor (rhbFGF) on angiogenesis during mandible fracture healing in rabbit. Methods: Fifty adult white rabbits were used for animal model and randomly divided into a control group (25 rabbits) and an experimental group (25 rabbits). The membranous complex of rhbFGF and bovine type I collagen was prepared and implanted into the rabbit mandible fracture site under periosteum. The animals were sacrificed on 7, 14, 28, 56 and 84 days respectively after operation and the whole mandibles were harvested. The expression of factor VIII related antigen (F8-RA) in callus was examined with immunohistochemical staining. Results: The amounts of microvascular formation in calluses in the rhbFGF-treating group on days 7, 14, 28 and 56 were more than those of the control group (P<0.01).Conclusions: The results indicated that rhbFGF could stimulate microvascular formation during mandible fracture healing in rabbits.

  3. [Instrument to collect data for critical patients based on the theory of basic human needs].

    Science.gov (United States)

    Bordinhão, Rosaura Costa; Almeida, Miriam de Abreu

    2012-06-01

    This is an exploratory study based on qualitative approach that aimed to collectively construct an instrument to collect data for patients in the Intensive Care Unit (ICU), based on the Theory of Basic Human Needs (NHB). Data collection was through a focus group with four nurses from the ICU and four residents from the Nursing-Health Integrated Residency (RIS) program in seven meetings in 2009. The discussions produced in each session were analyzed as recommended by Horta. The instrument was divided into seven groups and 17 subgroups of needs. After testing and suggestions from participants, we elaborated the final version of the instrument and a guidance manualfor completing it, according to the need expressed by the group. Validation of the instrument and the manual and inclusion of teaching of the nursing process in the RIS activity program are suggested.

  4. SPIRITUALITY AND SINCERITY AS BASIC "EXISTENTIALS" OF HUMAN EXISTENCE: THE PEDAGOGICAL CONTEXT

    Directory of Open Access Journals (Sweden)

    Yu. N. SINITSYN

    2015-01-01

    Full Text Available The article presents the philosophical-pedagogical and psychological analysis of the categories of "spirit," "soul" and "body", different views on the concepts of "spirituality", "sincerity" and "physicality." The "spirit" and "spirituality" is considered from the perspective of the unity of the three fundamental values of human existence (Truth, Goodness, Beauty, highlighting three areas of spiritual activity - knowledge, art, morality. "Soul" and "sincerity" are associated with the internal, mental world of people, their consciousness, basic principles determining the life of the body and the feelings, consciousness, sensations and will. "Body" and "physicality" are associated with the human body and its manifestations in the external, physical forms. Spirituality determines the content of a person's life. It goes far beyond just satisfaction of needs of the body and soul. The idea of the priority of spirituality in human development is presented in the ancient, classical German and Russian religious philosophy. The article highlights the formation process of the spiritual component of health and education of a person, presents the forms of spirituality and direction of spiritual knowledge. The concept of spirituality is considered in the context of spiritual - moral activity and spiritual -moral personality as the goal of education. Historically and epistemologically the notion of spirituality has two basic meanings: the religious and the secular. Both interpretations exist in modern society; both bear the traces of history and tradition reflecting the biblical wisdom, and the high sense of human existence and everyday life. Spirituality is a fundamental virtue of the person that combines spiritual needs and abilities of the person to realize himself in creative work as well as in striving for goodness, freedom and justice. Spirituality along with morals and ethics are fundamental concepts in the process of

  5. Four basic levels of the interactions between humanity and the imbalanced Nature

    Science.gov (United States)

    Kontar, V. A.

    2013-12-01

    There are the clearly distinguishable four basic levels of interaction the humanity with the imbalanced Nature: 1 Level - Naivety: Self-healing Nature in defiance of the humanity activities. 2 Level - Collaboration: Restoration of Nature in cooperation with humanity. 3 Level - Conflict: The resistance of Nature against the humanity's interference. 4 Level - Disappearance: Nature destroys humanity as the trouble maker. On the first level the people were afraid and respected Nature and are taking from Nature only what Nature gave willingly. Therefore Nature could easy regenerate itself. So it was thousands of years and people become under the false impression that it will be forever. The first signs the end of this period was visible in the era of industrialization. It turned out that resources are not infinite, and the waste of humanity grows much faster than Nature can utilize or dispose it. But in the world still had plenty of the untouched places and industrialization continued to develop rapidly. Thus problems with Nature were dislocated into the colonies rather far off from the prosperous metropolitan countries. The false impression about the man's victory over Nature has increased. Very soon the main untouched place was used, and the global circulations bring the pollutions from colonies to the metropolis. The second level was started as processes to creating the national parks, natural reservations, etc. It was some beginning of the cooperation humanity with Nature. The invasion into the Nature of the colonies was intensified. In addition start increasing the pollution in the metropolis from the waste of resources which have been imported from the colonies. The third level was started and Nature began to resist and revenge to the self-confident man. But man didn't stop and continued create more and more aggressive processes which provoked some avalanches-looks reactions of Nature. Now people can start these avalanches, but cannot stop it. One of these man

  6. Denis Browne: maverick or master surgeon?

    Science.gov (United States)

    Smith, D E

    2000-11-01

    The current generation of surgeons may remember Denis Browne only as an inventor of surgical instruments which few people use, an innovator of procedures condemned as inadequate, and a personality bristling with controversy: a maverick indeed. And yet this assessment belies his influence as the founder of modern paediatric surgery in the development of British surgery. Further, his innovative operations in a range of paediatric lesions were revolutionary in the context of the time. Browne was born in 1892 and educated in Australia, although his whole surgical career was in England. He had a remarkable family background; unique Australian experiences in childhood, when he commenced to display independence and individuality of spirit, through University, where he gained 'Blues' in tennis and shooting, to war, where he served in Gallipoli and France; and to controversies that surrounded him in his battle to establish paediatric surgery as a legitimate surgical discipline. He certainly had a prickly personality and a particular venom reserved for orthopaedic surgeons and anatomists, but his achievements may have been possible only by one possessed of such a strong and towering character.

  7. 15 CFR Supplement No. 2 to Part 740 - Items That May Be Donated To Meet Basic Human Needs Under the Humanitarian License Exception

    Science.gov (United States)

    2010-01-01

    ... Basic Human Needs Under the Humanitarian License Exception No. Supplement No. 2 to Part 740 Commerce and... Supplement No. 2 to Part 740—Items That May Be Donated To Meet Basic Human Needs Under the Humanitarian... Equipment for the Handicapped (f) Basic Support Equipment and Supplies Necessary To Operate and Administer...

  8. 77 FR 25133 - Order Temporarily Denying Export Privileges

    Science.gov (United States)

    2012-04-27

    ... back and forth between Tehran, Iran, and Bangkok, Thailand. Ramadan denied that any of the Tehran-Bangkok flights had occurred, but indicated that this aircraft currently is located in Iran with Aban...

  9. Bone marrow mesenchymal stem cells overexpressing human basic fibroblast growth factor increase vasculogenesis in ischemic rats

    Directory of Open Access Journals (Sweden)

    J.C. Zhang

    2014-10-01

    Full Text Available Administration or expression of growth factors, as well as implantation of autologous bone marrow cells, promote in vivo angiogenesis. This study investigated the angiogenic potential of combining both approaches through the allogenic transplantation of bone marrow-derived mesenchymal stem cells (MSCs expressing human basic fibroblast growth factor (hbFGF. After establishing a hind limb ischemia model in Sprague Dawley rats, the animals were randomly divided into four treatment groups: MSCs expressing green fluorescent protein (GFP-MSC, MSCs expressing hbFGF (hbFGF-MSC, MSC controls, and phosphate-buffered saline (PBS controls. After 2 weeks, MSC survival and differentiation, hbFGF and vascular endothelial growth factor (VEGF expression, and microvessel density of ischemic muscles were determined. Stable hbFGF expression was observed in the hbFGF-MSC group after 2 weeks. More hbFGF-MSCs than GFP-MSCs survived and differentiated into vascular endothelial cells (P<0.001; however, their differentiation rates were similar. Moreover, allogenic transplantation of hbFGF-MSCs increased VEGF expression (P=0.008 and microvessel density (P<0.001. Transplantation of hbFGF-expressing MSCs promoted angiogenesis in an in vivo hind limb ischemia model by increasing the survival of transplanted cells that subsequently differentiated into vascular endothelial cells. This study showed the therapeutic potential of combining cell-based therapy with gene therapy to treat ischemic disease.

  10. Bone marrow mesenchymal stem cells overexpressing human basic fibroblast growth factor increase vasculogenesis in ischemic rats

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, J.C. [Department of Vascular Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou (China); Zheng, G.F. [Department of Vascular Surgery, The People' s Hospital of Ganzhou, Ganzhou (China); Wu, L.; Ou Yang, L.Y.; Li, W.X. [Department of Vascular Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou (China)

    2014-08-08

    Administration or expression of growth factors, as well as implantation of autologous bone marrow cells, promote in vivo angiogenesis. This study investigated the angiogenic potential of combining both approaches through the allogenic transplantation of bone marrow-derived mesenchymal stem cells (MSCs) expressing human basic fibroblast growth factor (hbFGF). After establishing a hind limb ischemia model in Sprague Dawley rats, the animals were randomly divided into four treatment groups: MSCs expressing green fluorescent protein (GFP-MSC), MSCs expressing hbFGF (hbFGF-MSC), MSC controls, and phosphate-buffered saline (PBS) controls. After 2 weeks, MSC survival and differentiation, hbFGF and vascular endothelial growth factor (VEGF) expression, and microvessel density of ischemic muscles were determined. Stable hbFGF expression was observed in the hbFGF-MSC group after 2 weeks. More hbFGF-MSCs than GFP-MSCs survived and differentiated into vascular endothelial cells (P<0.001); however, their differentiation rates were similar. Moreover, allogenic transplantation of hbFGF-MSCs increased VEGF expression (P=0.008) and microvessel density (P<0.001). Transplantation of hbFGF-expressing MSCs promoted angiogenesis in an in vivo hind limb ischemia model by increasing the survival of transplanted cells that subsequently differentiated into vascular endothelial cells. This study showed the therapeutic potential of combining cell-based therapy with gene therapy to treat ischemic disease.

  11. Protest of doctors: a basic human right or an ethical dilemma.

    Science.gov (United States)

    Abbasi, Imran Naeem

    2014-03-10

    Peaceful protests and strikes are a basic human right as stated in the United Nations' universal declaration on human rights. But for doctors, their proximity to life and death and the social contract between a doctor and a patient are stated as the reasons why doctors are valued more than the ordinary beings. In Pakistan, strikes by doctors were carried out to protest against lack of service structure, security and low pay. This paper discusses the moral and ethical concerns pertaining to the strikes by medical doctors in the context of Pakistan. The author has carefully tried to balance the discussion about moral repercussions of strikes on patients versus the circumstances of doctors working in public sector hospitals of a developing country that may lead to strikes. Doctors are envisaged as highly respectable due to their direct link with human lives. Under Hippocrates oath, care of the patient is a contractual obligation for the doctors and is superior to all other responsibilities. From utilitarian perspective, doctors' strikes are justifiable only if there is evidence of long term benefits to the doctors, patients and an improvement in service delivery. Despite that, it is hard to justify such benefits against the risks to the patients. Harms that may incur to the patients include: prolongation of sufferings, irreversible damage to health, delay in treatment, death, loss of work and waste of financial resources.In a system of socialized medicine, government owing to greater control over resources and important managerial decisions should assume greater responsibility and do justice to all stakeholders including doctors as well as patients. If a doctor is underpaid, has limited options for career growth and is forced to work excessively, then not only quality of medical care and ability to act in the best interests of patients is adversely affected, it may also lead to brain drain. There is no single best answer against or in favor of doctors' industrial

  12. Missing in Mexico: Denied victims, neglected stories

    Directory of Open Access Journals (Sweden)

    Karl, Sylvia

    2014-12-01

    Full Text Available In this article, I will describe the mostly invisibilized “fight for rehumanization” of the families of the dehumanized disappeared of the Mexican Dirty War of the 1960s and 1970s. The conflictive memory politics in Mexico and the ambivalent transitional justice process led to processes of re-dehumanization for the families of the disappeared. Within these processes of clarification of past crimes, new spaces of violence emerged. The current “war on drugs” has caused an unprecedented number of new cases of disappearances. I will argue that there are continuities between the Dirty War in the past and the Dirty War practices within the present conflict. In this complex context of violence, the disappearances take place in a battlefield with blurred boundaries: disappearances for political reasons are intermingled with cases of disappearances due to organized crime and new fights for the rehumanization of the disappeared have evolved. In this climate of terror and fear, the families of the disappeared—those of the past and those of the present—are crucial counter-memory groups that object to official discourses that deny the crimes committed by the state.En este artículo, describiré la “lucha por la rehumanización” –en su mayoría invisibilizada– de las familias de los desaparecidos deshumanizados de la Guerra Sucia mexicana de los años 60 y 70. Las políticas de memoria conflictivas en México y el proceso de justicia transicional ambivalente llevaron a procesos de re-deshumanización de las familias de los desaparecidos. Dentro de estos procesos de clarificación sobre los crímenes pasados, nuevos espacios de violencia han emergido. La actual “guerra contra el narcotráfico” ha causado un número sin precedentes de nuevas desapariciones. Argumentaré que hay continuidades entre la Guerra Sucia en el pasado, y las prácticas de Guerra Sucia en el conflicto presente. En este complejo contexto de violencia, las

  13. Classic and Golli Myelin Basic Protein have distinct developmental trajectories in human visual cortex.

    Science.gov (United States)

    Siu, Caitlin R; Balsor, Justin L; Jones, David G; Murphy, Kathryn M

    2015-01-01

    Traditionally, myelin is viewed as insulation around axons, however, more recent studies have shown it also plays an important role in plasticity, axonal metabolism, and neuroimmune signaling. Myelin is a complex multi-protein structure composed of hundreds of proteins, with Myelin Basic Protein (MBP) being the most studied. MBP has two families: Classic-MBP that is necessary for activity driven compaction of myelin around axons, and Golli-MBP that is found in neurons, oligodendrocytes, and T-cells. Furthermore, Golli-MBP has been called a "molecular link" between the nervous and immune systems. In visual cortex specifically, myelin proteins interact with immune processes to affect experience-dependent plasticity. We studied myelin in human visual cortex using Western blotting to quantify Classic- and Golli-MBP expression in post-mortem tissue samples ranging in age from 20 days to 80 years. We found that Classic- and Golli-MBP have different patterns of change across the lifespan. Classic-MBP gradually increases to 42 years and then declines into aging. Golli-MBP has early developmental changes that are coincident with milestones in visual system sensitive period, and gradually increases into aging. There are three stages in the balance between Classic- and Golli-MBP expression, with Golli-MBP dominating early, then shifting to Classic-MBP, and back to Golli-MBP in aging. Also Golli-MBP has a wave of high inter-individual variability during childhood. These results about cortical MBP expression are timely because they compliment recent advances in MRI techniques that produce high resolution maps of cortical myelin in normal and diseased brain. In addition, the unique pattern of Golli-MBP expression across the lifespan suggests that it supports high levels of neuroimmune interaction in cortical development and in aging.

  14. Classic and Golli Myelin Basic Protein have distinct developmental trajectories in human visual cortex

    Directory of Open Access Journals (Sweden)

    Caitlin R Siu

    2015-04-01

    Full Text Available Traditionally myelin is viewed as insulation around axons however more recent studies have shown it plays an important role in plasticity, axonal metabolism and neuroimmune signalling. Myelin is a complex multi-protein structure composed of hundreds of proteins, with Myelin Basic Protein (MBP being the most studied. MBP has two families: Classic-MBP that is necessary for activity driven compaction of myelin around axons, and Golli-MBP that is found in neurons, oligodendrocytes, and T cells, and has been called a 'molecular link' between the nervous and immune systems. In visual cortex myelin proteins interact with immune processes to affect experience-dependent plasticity. We studied myelin in human visual cortex using Western blotting to quantify Classic- and Golli-MBP expression in post-mortem tissue samples ranging in age from 20 days to 80 years. We found that Classic- and Golli-MBP have different patterns of change across the lifespan: Classic-MBP gradually increases to 42 years and then declines into aging; Golli-MBP has changes that are coincident with milestones in visual system sensitive period, before gradually increasing into aging. There are 3 stages in the balance between Classic- and Golli-MBP expression, with Golli-MBP dominating early, then shifting to Classic-MBP, and back to Golli-MBP in aging. Also Golli-MBP has a wave of high inter-individual variability during childhood. These results about cortical MBP expression are timely because they compliment recent advances in MRI techniques that produce high resolution maps of cortical myelin in normal and diseased brain. In addition the unique pattern of Golli-MBP expression across the lifespan suggests that it supports high levels of neuroimmune interaction in cortical development and in aging.

  15. Ontogeny of expression of basic fibroblast growth factor and its receptors in human fetal skin

    Institute of Scientific and Technical Information of China (English)

    CHEN Wei; FU Xiao-bing; GE Shi-li; SUN Tong-zhu; SHENG Zhi-yong

    2005-01-01

    Objective : To investigate the expression characteristics of basic fibroblast growth factor (bFGF)and its receptors, flg ( FGFR1 ) and bek ( FGFR2), in fetal skin at different gestational ages underlying the relevance of these 3 proteins to skin development and the mechanisms underlying the phenotypic transition from scarless to scarforming healing.Methods: Eighteen specimens of fetal skin biopsies of human embryo were obtained from spontaneous abortions at different gestational ages of 13-32 weeks. Gene expression of bFGF, bek and flg was examined with reverse transcription-polymerase chain reaction (RT-PCR). The dynamic expression and distribution of these 3 proteins were detected with streptavidin peroxidase ( SP )immunohistochemical staining method.Results: In the early gestational fetal skin, genes of bFGF and flg were strongly expressed and more protein contents of these 2 proteins were found as compared with the genes at late gestation fetal skin (2.446 ± 0.116 and 2.066 ± 0. 152 versus 2.157 ± 0. 101 and 1.818 ± 0.086,respectively, P < 0.05). On the contrary, the levels of gene expression and protein content of bek were not differently expressed in the early gestational fetal skin versus the late ones. Protein particles of bFGF were mainly distributed in the epidermal cells and some fibroblasts. Bek was mainly located in the cell membrane and cytoplasm of epidermal cells while flg protein was principally located in the epidermal cells, endothelial cells and some fibroblasts.Conclusions: The endogenous bFGF and their receptors might be involved in the cutaneous development at fetal stage. The differently expressing levels of bFGF and flg during gestation may be related to scarless or scarforming repair during gestation.

  16. Maurice Denis dans la Grande Guerre Maurice Denis in the Great War

    Directory of Open Access Journals (Sweden)

    Fabienne Stahl

    2012-03-01

    Full Text Available Maurice Denis (1870-1943 did not participate actively in the First World War, but this period inevitably brought a break in his life and in his work. Although he was found medically unfit to serve on the front line, the patriotic élan he felt led him to become involved in the war effort: he was mobilised as a railway guard in Conches (Eure and was subsequently attached to the military administration in Evreux in 1914-1915; drawings and paintings bear witness to this confused and unsettled period for the artist. Despite having home leave for the birth of his sixth child, he remained committed to the war effort. In October 1917, he undertook a mission as an army painter; noting the devastation caused by war in several (unpublished sketchbooks, showing a detailed and poignant vision of ruined bridges, castles, churches, etc.. When Victory was finally achieved, he devoted himself to the task of commemoration.

  17. Osteoarthritis-associated basic calcium phosphate crystals activate membrane proximal kinases in human innate immune cells.

    Science.gov (United States)

    Corr, Emma M; Cunningham, Clare C; Helbert, Laura; McCarthy, Geraldine M; Dunne, Aisling

    2017-02-07

    Osteoarthritis (OA) is a chronic debilitating joint disorder of particularly high prevalence in the elderly population. Intra-articular basic calcium phosphate (BCP) crystals are present in the majority of OA joints and are associated with severe degeneration. They are known to activate macrophages, synovial fibroblasts, and articular chondrocytes, resulting in increased cell proliferation and the production of pro-inflammatory cytokines and matrix metalloproteases (MMPs). This suggests a pathogenic role in OA by causing extracellular matrix degradation and subchondral bone remodelling. There are currently no disease-modifying drugs available for crystal-associated OA; hence, the aim of this study was to explore the inflammatory pathways activated by BCP crystals in order to identify potential therapeutic targets to limit crystal-induced inflammation. Primary human macrophages and dendritic cells were stimulated with BCP crystals, and activation of spleen tyrosine kinase (Syk), phosphoinositide-3 kinase (PI3K), and mitogen-activated protein kinases (MAPKs) was detected by immunoblotting. Lipopolysaccharide (LPS)-primed macrophages were pre-treated with inhibitors of Syk, PI3K, and MAPKs prior to BCP stimulation, and cytokine production was quantified by enzyme-linked immunosorbent assay (ELISA). Aa an alternative, cells were treated with synovial fluid derived from osteoarthritic knees in the presence or absence of BCP crystals, and gene induction was assessed by real-time polymerase chain reaction (PCR). We demonstrate that exposure of primary human macrophages and dendritic cells to BCP crystals leads to activation of the membrane-proximal tyrosine kinases Syk and PI3K. Furthermore, we show that production of the pro-inflammatory cytokines interleukin (IL)-1α and IL-1β and phosphorylation of downstream MEK and ERK MAPKs is suppressed following treatment with inhibitors of Syk or PI3K. Finally, we demonstrate that treatment of macrophages with BCP crystals

  18. Abortion denied--outcome of mothers and babies.

    Science.gov (United States)

    Del Campo, C

    1984-02-15

    A consistent argument favoring therapeutic abortions has been that mothers who are denied abortions will seek "illegal" help elsewhere, often in less than optimal conditions. Yet, a review of published reports on women who had been denied abortion and were followed up shows that 70.67% of the 6298 women completed their pregnancies and only 13.2% had an abortion elsewhere. Several studies have shown that the incidence of Complications of pregnancy is no greater in mothers denied abortion than in paired controls. The results of a prospective study by Laukaran and Van Den Berg showed a higher incidence of maternal accidental injury, a borderline increase of maternal accidental injury, a borderline increase in the prevalence of congenital anomalies, and a higher incidence of infection and hemorrhage during the puerperium in women who had been denied abortion. They concluded that maternal attitude and psychosocial stress had little effect on the progress of the pregnancy and labor. Published reports on the psychological effects on the children of women who had been denied abortion are few, mainly because longterm follow-up is required. In 1966 Forssman and Thuwe described the results of their study of 120 children whose mothers had been denied abortion. The children had been followed up until their 21st birthdays. The controls had been carefully paired. The proportion of children who had been placed in foster and children's homes was significantly higher among the "unwanted" children than among the controls (50% versus 18%). There was no statistically significant difference in the rates of drunken misconduct, crime, or "educational mental subnormality" between the 2 groups, but the incidence rates of delinquency and psychiatric consultation were 10% and 13% higher respectively among the unwanted children than among the controls. There have been virtually no objective studies on the psychologic and social well-being of women who have been denied abortion. The literature

  19. Body Basics

    Science.gov (United States)

    ... more about how the body works, what basic human anatomy is, and what happens when parts of the body don't function properly. Blood Bones, Muscles, and Joints Brain and Nervous System Digestive System Endocrine System Eyes Female Reproductive System Heart and Circulatory System Immune ...

  20. Localization system for use in GPS denied environments

    Energy Technology Data Exchange (ETDEWEB)

    Trueblood, J. J. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2017-02-01

    The military uses to autonomous platforms to complete missions to provide standoff for the warfighters. However autonomous platforms rely on GPS to provide their global position. In many missions spaces the autonomous platforms may encounter GPS denied environments which limits where the platform operates and requires the warfighters to takes its place. GPS denied environments can occur due to tall building, trees, canyon wall blocking the GPS satellite signals or a lack of coverage. An Inertial Navigation System (INS) uses sensors to detect the vehicle movement and direction its traveling to calculate the vehicle. One of biggest challenges with an INS system is the accuracy and accumulation of errors over time of the sensors. If these challenges can be overcome the INS would provide accurate positioning information to the autonomous vehicle in GPS denied environments and allow them to provide the desired standoff for the warfighters.

  1. Basic level category structure emerges gradually across human ventral visual cortex.

    Science.gov (United States)

    Iordan, Marius Cătălin; Greene, Michelle R; Beck, Diane M; Fei-Fei, Li

    2015-07-01

    Objects can be simultaneously categorized at multiple levels of specificity ranging from very broad ("natural object") to very distinct ("Mr. Woof"), with a mid-level of generality (basic level: "dog") often providing the most cognitively useful distinction between categories. It is unknown, however, how this hierarchical representation is achieved in the brain. Using multivoxel pattern analyses, we examined how well each taxonomic level (superordinate, basic, and subordinate) of real-world object categories is represented across occipitotemporal cortex. We found that, although in early visual cortex objects are best represented at the subordinate level (an effect mostly driven by low-level feature overlap between objects in the same category), this advantage diminishes compared to the basic level as we move up the visual hierarchy, disappearing in object-selective regions of occipitotemporal cortex. This pattern stems from a combined increase in within-category similarity (category cohesion) and between-category dissimilarity (category distinctiveness) of neural activity patterns at the basic level, relative to both subordinate and superordinate levels, suggesting that successive visual areas may be optimizing basic level representations.

  2. Time Really Passes, Science Can't Deny That

    CERN Document Server

    Gisin, Nicolas

    2016-01-01

    Today's science provides quite a lean picture of time as a mere geometric evolution parameter. I argue that time is much richer. In particular, I argue that besides the geometric time, there is creative time, when objective chance events happen. The existence of the latter follows straight from the existence of free-will. Following the french philosopher Lequyer, I argue that free-will is a prerequisite for the possibility to have rational argumentations, hence can't be denied. Consequently, science can't deny the existence of creative time and thus that time really passes.

  3. Scope of a nursing diagnostic list for fulfilling basic human needs in home-visit nursing.

    Science.gov (United States)

    Esaki, Fusako; Muranaka, Yoko; Tamaki, Miyoko; Akiba, Kimiko; Aoki, Ryouko

    2006-01-01

    Inscriptions on 291 nursing diagnosis items regarding 100 home convalescents were subjected to analysis. The 291-item nursing diagnosis was found to be consistent with a previously reported nursing diagnosis developed by the authors from Henderson's 14 items covering basic nursing practice. Additionally, the analysis indicated a need for nursing diagnosis items for family members, as caregivers for the patients recuperating at home.

  4. Secreted proteoglycans directly mediate human embryonic stem cell-basic fibroblast growth factor 2 interactions critical for proliferation.

    Science.gov (United States)

    Levenstein, Mark E; Berggren, W Travis; Lee, Ji Eun; Conard, Kevin R; Llanas, Rachel A; Wagner, Ryan J; Smith, Lloyd M; Thomson, James A

    2008-12-01

    Human embryonic stem (ES) cells can be maintained in an undifferentiated state if the culture medium is first conditioned on a layer of mouse embryonic fibroblast (MEF) feeder cells. Here we show that human ES cell proliferation is coordinated by MEF-secreted heparan sulfate proteoglycans (HSPG) in conditioned medium (CM). These HSPG and other heparinoids can stabilize basic fibroblast growth factor (FGF2) in unconditioned medium at levels comparable to those observed in CM. They also directly mediate binding of FGF2 to the human ES cell surface, and their removal from CM impairs proliferation. Finally, we have developed a purification scheme for MEF-secreted HSPG in CM. Using column chromatography, immunoblotting, and mass spectrometry-based proteomic analysis, we have identified multiple HSPG species in CM. The results demonstrate that HSPG are key signaling cofactors in CM-based human ES cell culture.

  5. The Human-Computer Interface and Information Literacy: Some Basics and Beyond.

    Science.gov (United States)

    Church, Gary M.

    1999-01-01

    Discusses human/computer interaction research, human/computer interface, and their relationships to information literacy. Highlights include communication models; cognitive perspectives; task analysis; theory of action; problem solving; instructional design considerations; and a suggestion that human/information interface may be a more appropriate…

  6. Child Soldiers: Rights Denied, Hope Restored

    Science.gov (United States)

    Carano, Kenneth T.; Bailey, Robert W.

    2012-01-01

    The forceful induction of children as child soldiers is an abhorrent violation of human rights. It is very disturbing that while many children are forcibly recruited into armed conflicts, others actually volunteer, due to their nightmarish alternatives. Although the practice has recently gained worldwide attention, awareness alone will not end the…

  7. 50 CFR 635.41 - Products denied entry.

    Science.gov (United States)

    2010-10-01

    ... vessel listed on the ICCAT record as engaged in illegal, unreported, and unregulated fishing will be... included on the ICCAT list as engaged in illegal, unreported, and unregulated fishing will be denied entry... ICCAT convention area by a fishing vessel that is required to be listed, but not listed on the...

  8. Working in Development Ethics - a tribute to Denis Goulet

    NARCIS (Netherlands)

    D.R. Gasper (Des)

    2006-01-01

    markdownabstractABSTRACT Denis Goulet (1931-2006) was probably the main founder of work on ‘development ethics’ as a self-conscious field that treats the ethical and value questions posed by development theory, planning and practice. This overview of a selection of papers presented at a conference

  9. Denis Diderot (1713-1784): Enlightener, Encyclopedist, Educator.

    Science.gov (United States)

    Brickman, William W.

    1984-01-01

    The eminent eighteenth-century encyclopedia editor and French philosopher, Denis Diderot, exercised a powerful influence on thought and culture in Western and Eastern Europe. He was interested and involved in educational activities and ideas and contributed to pedagogical literature. His life, work, and educational thought are examined. (RM)

  10. An upcoming program for medical humanities education in Fudan University's School of Basic Medical Sciences.

    Science.gov (United States)

    Liu, Ye; Cheng, Xunjia

    2017-05-23

    Ideal medical care requires professional skills as well as appropriate communication skills. However, traditional medical education in medical schools mostly emphasizes the former. To remedy this situation, medical humanities education will be incorporated into education for medical students at Fudan University. Comprehensive medical education that includes both medical skills and humanities may greatly improve medical care.

  11. Basic multisensory functions can be acquired after congenital visual pattern deprivation in humans.

    Science.gov (United States)

    Putzar, Lisa; Gondan, Matthias; Röder, Brigitte

    2012-01-01

    People treated for bilateral congenital cataracts offer a model to study the influence of visual deprivation in early infancy on visual and multisensory development. We investigated cross-modal integration capabilities in cataract patients using a simple detection task that provided redundant information to two different senses. In both patients and controls, redundancy gains were consistent with coactivation models, indicating an integrated processing of modality-specific information. This finding is in contrast with recent studies showing impaired higher-level multisensory interactions in cataract patients. The present results suggest that basic cross-modal integrative processes for simple short stimuli do not depend on visual and/or crossmodal input since birth.

  12. Why human evolution should be a basic science for medicine and psychology students.

    Science.gov (United States)

    Palanza, Paola; Parmigiani, Stefano

    2016-06-20

    Based on our teaching experience in medicine and psychology degree programs, we examine different aspects of human evolution that can help students to understand how the human body and mind work and why they are vulnerable to certain diseases. Three main issues are discussed: 1) the necessity to consider not only the mechanisms, i.e. the "proximate causations", implicated in biological processes but also why these mechanisms have evolved, i.e. the "ultimate causations" or "adaptive significance", to understand the functioning and malfunctioning of human body and mind; 2) examples of how human vulnerabilities to disease are caused by phylogenetic constraints, evolutionary tradeoffs reflecting the combined actions of natural and sexual selection, and/or mismatch between past and present environment (i.e., evolution of the eye, teeth and diets, erect posture and their consequences); 3) human pair-bonding and parent-offspring relationships as the result of socio-sexual selection and evolutionary compromises between cooperation and conflict. These psychobiological mechanisms are interwoven with our brain developmental plasticity and the effects of culture in shaping our behavior and mind, and allow a better understanding of functional (normal) and dysfunctional (pathological) behaviors. Thus, because the study of human evolution offers a powerful framework for clinical practice and research, the curriculum studiorum of medical and psychology students should include evolutionary biology and human phylogeny.

  13. Performance-driven facial animation: basic research on human judgments of emotional state in facial avatars.

    Science.gov (United States)

    Rizzo, A A; Neumann, U; Enciso, R; Fidaleo, D; Noh, J Y

    2001-08-01

    Virtual reality is rapidly evolving into a pragmatically usable technology for mental health (MH) applications. As the underlying enabling technologies continue to evolve and allow us to design more useful and usable structural virtual environments (VEs), the next important challenge will involve populating these environments with virtual representations of humans (avatars). This will be vital to create mental health VEs that leverage the use of avatars for applications that require human-human interaction and communication. As Alessi et al.1 pointed out at the 8th Annual Medicine Meets Virtual Reality Conference (MMVR8), virtual humans have mainly appeared in MH applications to "serve the role of props, rather than humans." More believable avatars inhabiting VEs would open up possibilities for MH applications that address social interaction, communication, instruction, assessment, and rehabilitation issues. They could also serve to enhance realism that might in turn promote the experience of presence in VR. Additionally, it will soon be possible to use computer-generated avatars that serve to provide believable dynamic facial and bodily representations of individuals communicating from a distance in real time. This could support the delivery, in shared virtual environments, of more natural human interaction styles, similar to what is used in real life between people. These techniques could enhance communication and interaction by leveraging our natural sensing and perceiving capabilities and offer the potential to model human-computer-human interaction after human-human interaction. To enhance the authenticity of virtual human representations, advances in the rendering of facial and gestural behaviors that support implicit communication will be needed. In this regard, the current paper presents data from a study that compared human raters' judgments of emotional expression between actual video clips of facial expressions and identical expressions rendered on a

  14. Human eosinophil major basic protein is an endogenous allosteric antagonist at the inhibitory muscarinic M2 receptor.

    OpenAIRE

    Jacoby, D B; Gleich, G J; Fryer, A. D.

    1993-01-01

    The effect of human eosinophil major basic protein (MBP) as well as other eosinophil proteins, on binding of [3H]N-methyl-scopolamine ([3H]NMS: 1 x 10(-10) M) to muscarinic M2 receptors in heart membranes and M3 receptors in submandibular gland membranes was studied. MBP inhibited specific binding of [3H]NMS to M2 receptors but not to M3 receptors. MBP also inhibited atropine-induced dissociation of [3H]NMS-receptor complexes in a dose-dependent fashion, demonstrating that the interaction of ...

  15. Human engineered heart tissue as a versatile tool in basic research and preclinical toxicology.

    Directory of Open Access Journals (Sweden)

    Sebastian Schaaf

    Full Text Available Human embryonic stem cell (hESC progenies hold great promise as surrogates for human primary cells, particularly if the latter are not available as in the case of cardiomyocytes. However, high content experimental platforms are lacking that allow the function of hESC-derived cardiomyocytes to be studied under relatively physiological and standardized conditions. Here we describe a simple and robust protocol for the generation of fibrin-based human engineered heart tissue (hEHT in a 24-well format using an unselected population of differentiated human embryonic stem cells containing 30-40% α-actinin-positive cardiac myocytes. Human EHTs started to show coherent contractions 5-10 days after casting, reached regular (mean 0.5 Hz and strong (mean 100 µN contractions for up to 8 weeks. They displayed a dense network of longitudinally oriented, interconnected and cross-striated cardiomyocytes. Spontaneous hEHT contractions were analyzed by automated video-optical recording and showed chronotropic responses to calcium and the β-adrenergic agonist isoprenaline. The proarrhythmic compounds E-4031, quinidine, procainamide, cisapride, and sertindole exerted robust, concentration-dependent and reversible decreases in relaxation velocity and irregular beating at concentrations that recapitulate findings in hERG channel assays. In conclusion this study establishes hEHT as a simple in vitro model for heart research.

  16. The Basic Principles of China's Development of Human Rights and NGOs

    Institute of Scientific and Technical Information of China (English)

    LiuJingqin; WangWei

    2004-01-01

    From July 6 to 7,2004,co-sponsored by Chinese Association for International Understanding (CAFIU),China Foundation for Human Rights Development (CFHRD) and the Friedrich Ebert Foundation of Germany (Ebert Foundation),the 6th Sino-German Seminar on Human Rights was held in Berlin of Germany.Mr.Liu Jingqin,head of the Chinese delegation,senior advisor of CFHRD and Vice President of Chinese People's Association for Peace and Disarmament,made a keynote speech at the seminar.The following is the full text of his speech.

  17. Literature in Focus - Meet the author Denis Guedj

    CERN Multimedia

    2009-01-01

    Author of some fifteen works, mostly novels, Denis Guedj comforts us in our belief that science and literature, far from being poles apart, can combine to make the most wonderful TRUE stories. Fiction is not in opposition to truth but offers it an emotional dimension, while discipline and imagination unite to enrich the novels. Denis Guedj will, among other things, present his recent works: Villa des hommes (R. Laffont) and One zéro show ( Seuil). The latter is a play which the author will stage at CERN on 16 November. After the presentation, the author will be available to sign copies of his books. Wednesday 7 October 2009 at 4.00 p.m., Library (Bldg 52/1-052). Tea and coffee will be served.

  18. How Human Information Behaviour Researchers Use Each Other's Work: A Basic Citation Analysis Study

    Science.gov (United States)

    McKechnie, Lynne E. F.; Goodall, George R.; Lajoie-Paquette, Darian; Julien, Heidi

    2005-01-01

    Introduction: The purpose of this study was to determine if and how human information behaviour (HIB) research is used by others. Method: Using ISI Web of Knowledge, a citation analysis was conducted on 155 English-language HIB articles published from 1993 to 2000 in six prominent LIS journals. The bibliometric core of 12 papers was identified.…

  19. Receiving versus being denied an abortion and subsequent tobacco use.

    Science.gov (United States)

    Roberts, Sarah C M; Foster, Diana Greene

    2015-03-01

    The negative health consequences of tobacco use are well documented. Some research finds women receiving abortions are at increased risk of subsequent tobacco use. This literature has methodological problems, most importantly, inappropriate comparison groups. This study uses data from the Turnaway Study, a longitudinal study of women who all sought, but did not all receive, abortions at 30 facilities across the United States. Participants included women presenting just before an abortion facility's gestational age limit who received abortions (Near Limit Abortion Group, n = 452), just after the gestational limit who were denied abortions (Turnaways, n = 231), and who received first trimester abortions (First Trimester Abortion Group, n = 273). This study examined the association between receiving versus being denied an abortion and subsequent tobacco use over 2-years. Trajectories of tobacco use over 2 years were compared using multivariate mixed effects regression. Women receiving abortion maintained their level of tobacco use over 2 years. Women denied abortion initially had lower levels of tobacco use than women receiving abortion, but increased their tobacco use from 1 week through 12-18 months post-abortion seeking and then decreased their use by 2 years post-abortion seeking. Baseline parity modified these associations. Receiving an abortion was not associated with an increase in tobacco use over time. Overall, women who carry unwanted pregnancies to term appear to demonstrate similar cessation and resumption patterns to other pregnant women.

  20. Expression of a Functional Recombinant Human Basic Fibroblast Growth Factor from Transgenic Rice Seeds

    Directory of Open Access Journals (Sweden)

    Daichang Yang

    2013-02-01

    Full Text Available Basic fibroblast growth factor (FGF-2 is an important member of the FGF gene family. It is widely used in clinical applications for scald and wound healing in order to stimulate cell proliferation. Further it is applied for inhibiting stem cell differentiation in cultures. Due to a shortage of plasma and low expression levels of recombinant rbFGF in conventional gene expression systems, we explored the production of recombinant rbFGF in rice grains (Oryza sativa bFGF, OsrbFGF. An expression level of up to 185.66 mg/kg in brown rice was obtained. A simple purification protocol was established with final recovery of 4.49% and resulting in a yield of OsrbFGF reaching up to 8.33 mg/kg OsrbFGF. The functional assay of OsrbFGF indicated that the stimulating cell proliferation activity on NIH/3T3 was the same as with commercialized rbFGF. Wound healing in vivo of OsrbFGF is equivalent to commercialized rbFGF. Our results indicate that rice endosperm is capable of expressing small molecular mass proteins, such as bFGF. This again demonstrates that rice endosperm is a promising system to express various biopharmaceutical proteins.

  1. Serodiagnosis of Mycobacterium avium complex disease in humans: translational research from basic mycobacteriology to clinical medicine.

    Science.gov (United States)

    Kobayashi, Kazuo

    2014-01-01

    Rapid and accurate diagnosis of infectious diseases, including mycobacterial disease such as tuberculosis (TB) and diseases due to nontuberculous mycobacteria (NTM), is a very important element of global health. The gold standard in diagnosis of mycobacterial diseases remains clinical examination, combined with direct microscopic examination of sputum and culture of bacteria. Culture of slowly growing mycobacteria, including Mycobacterium tuberculosis and NTM (such as M. avium complex: MAC), can take up to 4 to 6 weeks, and in 10-20% of cases the bacillus is not successfully cultivated. Diagnosis of MAC pulmonary disease (MAC-PD) is complicated and time-consuming (usually at least 1 month). I have characterized the nature of MAC antigens and immune responses from the aspect of basic mycobacteriology, and then translated to clinical science. My multicenter study in Japan has demonstrated the usefulness of a serodiagnostic test to determine serum IgA antibodies against mycobacterial glycopeptidolipid (GPL) core antigen for diagnosing MAC-PD within a few hours. To validate in a larger number of patients, at diverse geographic locations, and among other races, the test was also assessed the usefulness internationally in the United States and Taiwan. In this review, I discuss development of serodiagnosis of MAC-PD by translational research and international collaboration study.

  2. Uptake and presentation of myelin basic protein by normal human B cells

    DEFF Research Database (Denmark)

    Brimnes, Marie Klinge; Hansen, Bjarke Endel; Nielsen, Leif Kofoed

    2014-01-01

    B cells may play both pathogenic and protective roles in T-cell mediated autoimmune diseases such as multiple sclerosis (MS). These functions relate to the ability of B cells to bind and present antigens. Under serum-free conditions we observed that 3-4% of circulating B cells from healthy donors...... were capable of binding the MS-associated self-antigen myelin basic protein (MBP) and of presenting the immunodominant peptide MBP85-99, as determined by staining with the mAb MK16 recognising the peptide presented by HLA-DR15-positive cells. In the presence of serum, however, the majority of B cells...... bound MBP in a complement-dependent manner, and almost half of the B cells became engaged in presentation of MBP85-99. Even though complement receptor 1 (CR1, CD35) and CR2 (CD21) both contributed to binding of MBP to B cells, only CR2 was important for the subsequent presentation of MBP85-99. A high...

  3. Resurrection of the Island Rule: Human-Driven Extinctions Have Obscured a Basic Evolutionary Pattern.

    Science.gov (United States)

    Faurby, Søren; Svenning, Jens-Christian

    2016-06-01

    Islands are or have been occupied by unusual species, such as dwarf proboscideans and giant rodents. The discussion of the classical but controversial island rule-which states that mammalian body sizes converge on intermediate sizes on islands-has been stimulated by these unusual species. In this study, we use an unprecedented global data set of the distributions and body sizes of late Quaternary mammal species and a novel analytical method to analyze body size evolution on islands. The analyses produced strong support for the island rule. Islands have suffered massive human-driven losses of species, and we found that the support for the island rule was substantially stronger when the many late Quaternary extinct species were also considered (particularly the tendency for dwarfing in large taxa). The decisive support for the island rule in this study confirms that evolution plays out in a markedly different way on islands and that human impact may obscure even fundamental evolutionary patterns.

  4. Comparative analysis of the nuclear basic proteins in rat, human, guinea pig, mouse and rabbit spermatozoa.

    Science.gov (United States)

    Calvin, H I

    1976-06-15

    Cysteine-rich protamines (Arg = 47-61%, Cys = 8-16%) were isolated from the sperm of an individual guinea pig, human and rabbit and from pooled samples of mouse and rat sperm. Appreciable concentrations of histones were not found in the sperm nuclei of these species. In addition to the protamines, a substance of relatively low molecular weight, which reacted with the Lowry reagent, appeared in crude acid-soluble extracts of sperm nucleoprotein. This unidentified contaminent was resolved from the protamines by chromatography on Bio-Rex 70. Heterogeneity of human and mouse protamines was revealed by electrophoresis at pH 2.7, in the presence of 2.5 M urea, and confirmed by amino acid analysis, which also suggested the presence of 2 or more species of protamine in the rabbit. By contrast, the guinea pig and rat preparations displayed nearly stoichiometric ratios of amino acid residues, approaching homogeneity by this criterion. The functional consequences of crosslinks between cysteine residues of these proteins and the possible species-specific significance of their differing percentages of histidine are discussed. Potentially analogous functions are suggested for phosphorylated serine and threonine, and for ionized cysteine and tyrosine, within the protamines of developing spermatids. Their amino acid compositions indicate that the protamines of eutherian mammals are coded by a C.G-rich genome which has been unusually susceptible to genetic drift. An especially high rate of G leads to A transitions seems to have occurred in the human protamine genes.

  5. Basic human values in a young group: advances in exploratory study

    Directory of Open Access Journals (Sweden)

    Lilian R. Daset Carreto

    2015-09-01

    Full Text Available This work is part of a wide area of Study, developed since 1998 and focused on Childhood and Adolescence. At first, the aim was to research the psychopathological profile of adolescents, with sociodemographic variables. Further on Competence, Coping and Values were added for an approach from the Positive Psychology (Dahlsgaard, Peterson & Seligman, 2005. This article presents the preliminar results of a youth sample of secondary level students (n=152, aged 12 to 18, male and female, belonging to a medium socioeconomical status. The instrument used for the study is the Basic Values Questionnaire, developed by Valdiney V. Gouveia (1998, based on the studies of S. Schwartz and W. Bilsky (1987, 1990, 2004. Once the performance of this instrument was tested with our Spanish speaking population, some linguistic adaptations were implemented. To obtain the profile of the interviewed adolescents, descriptive statistic is used. The results show to statistically significant difference between girls and boys in Experimenting and Realization Values (Personnel Values Group; as well in Existence (Central Category Value and in Normative (Social Value, with bigger M quantity in Suprapersonnel Value (Central Value and Interaction (Social Category Value. In response to open questions about the most and the least important values, subjects have chosen Interaction (Social Value and Existence Values (Central Value as the most important ones, and Realization Values (Personal Value and the Normative Values (Central Value Category, as the least important ones. The study shows the importance of some groups of Values, what would require an analysis in relation to the behaviours with those that are expressed and their cultural relevance. The conclusions open the debate, from the own expression of the value and their relationship with the psychopathology and on the other hand with the well-being. 

  6. Uptake and presentation of myelin basic protein by normal human B cells.

    Directory of Open Access Journals (Sweden)

    Marie Klinge Brimnes

    Full Text Available B cells may play both pathogenic and protective roles in T-cell mediated autoimmune diseases such as multiple sclerosis (MS. These functions relate to the ability of B cells to bind and present antigens. Under serum-free conditions we observed that 3-4% of circulating B cells from healthy donors were capable of binding the MS-associated self-antigen myelin basic protein (MBP and of presenting the immunodominant peptide MBP85-99, as determined by staining with the mAb MK16 recognising the peptide presented by HLA-DR15-positive cells. In the presence of serum, however, the majority of B cells bound MBP in a complement-dependent manner, and almost half of the B cells became engaged in presentation of MBP85-99. Even though complement receptor 1 (CR1, CD35 and CR2 (CD21 both contributed to binding of MBP to B cells, only CR2 was important for the subsequent presentation of MBP85-99. A high proportion of MBP85-99 presenting B cells expressed CD27, and showed increased expression of CD86 compared to non-presenting B cells. MBP-pulsed B cells induced a low frequency of IL-10-producing CD4+ T cells in 3 out of 6 donors, indicating an immunoregulatory role of B cells presenting MBP-derived peptides. The mechanisms described here refute the general assumption that B-cell presentation of self-antigens requires uptake via specific B-cell receptors, and may be important for maintenance of tolerance as well as for driving T-cell responses in autoimmune diseases.

  7. Body Basics Library

    Science.gov (United States)

    ... Sport for You Shyness About the Body Basics Library KidsHealth > For Teens > About the Body Basics Library Print A A A Did you ever wonder ... system, part, and process works. Use this medical library to find out about basic human anatomy, how ...

  8. Body Basics Library

    Science.gov (United States)

    ... of Healthy Breakfasts Shyness About the Body Basics Library KidsHealth > For Teens > About the Body Basics Library A A A Did you ever wonder what ... system, part, and process works. Use this medical library to find out about basic human anatomy, how ...

  9. Basic fibroblast growth factor and its receptors in human embryonic stem cells.

    Directory of Open Access Journals (Sweden)

    Ales Hampl

    2005-12-01

    Full Text Available Human embryonic stem cells (hESCs are pluripotent stem cells with long-lasting capacity to self-renew and differentiate into various cell types of endodermal, ectodermal or mesodermal origin. Unlike mouse ESCs (mESCs, which can be maintained in an undifferentiated state simply by adding leukemia inhibitory factor (LIF into the culture medium, hESCs are notorious for the sustained willingness to differentiate and not yet clearly defined signaling pathways that are crucial for their "stemness". Presently, our knowledge involves only limited number of growth factor signaling pathways that appear to be biologically relevant for stem cell functions in vitro. These include BMP, TGFbeta, Wnt, and FGF signaling pathway. The purpose of this review is to summarize recent data on the expression of FGFs and their receptors in hESCs, and critically evaluate the potential effects of FGF signals for their undifferentiated growth and/or differentiation in context with our current understanding of FGF/FGFR biology.

  10. Towards an integrative post-2015 sustainable development goal framework: Focusing on global justice – peace, security and basic human rights

    Directory of Open Access Journals (Sweden)

    George R. Lueddeke

    2015-12-01

    To strengthen the likelihood of realizing the post-2015 Sustainable Development Goals (SDGs, particularly with regard to “planet and population” health and well-being , UN and other decision-makers are urged to consider the adoption of an integrated SDG framework that is based on (i a vision of global justice - underpinned by peace, security and basic human rights; (ii the development of interdependent and interconnected strategies for each of the eleven thematic indicators identified in the UN document The World We Want; and (iii the application of guiding principles to measure the impact of SDG strategies in terms of holism, equity, sustainability, ownership, and global obligation. While current discussions on the SDGs are making progress in a number of areas, the need for integration of these around a common global vision and purpose seems especially crucial to avoid MDG shortcomings.

  11. N- and O-linked glycosylation site profiling of the human basic salivary proline-rich protein 3M.

    Science.gov (United States)

    Manconi, Barbara; Cabras, Tiziana; Sanna, Monica; Piras, Valentina; Liori, Barbara; Pisano, Elisabetta; Iavarone, Federica; Vincenzoni, Federica; Cordaro, Massimo; Faa, Gavino; Castagnola, Massimo; Messana, Irene

    2016-05-01

    In the present study, we show that the heterogeneous mixture of glycoforms of the basic salivary proline-rich protein 3M, encoded by PRB3-M locus, is a major component of the acidic soluble fraction of human whole saliva in the first years of life. Reversed-phase high-performance liquid chromatography with high-resolution electrospray ionization mass spectrometry analysis of the intact proteoforms before and after N-deglycosylation with Peptide-N-Glycosidase F and tandem mass spectrometry sequencing of peptides obtained after Endoproteinase GluC digestion allowed the structural characterization of the peptide backbone and identification of N- and O-glycosylation sites. The heterogeneous mixture of the proteoforms derives from the combination of 8 different neutral and sialylated glycans O-linked to Threonine 50, and 33 different glycans N-linked to Asparagine residues at positions 66, 87, 108, 129, 150, 171, 192, and 213.

  12. Brain Basics

    Medline Plus

    Full Text Available ... Brain Research Glossary Brain Basics (PDF, 10 pages) Introduction Watch the Brain Basics video Welcome. Brain Basics ... brain may play a role in disorders like schizophrenia or attention deficit hyperactivity disorder (ADHD) . Glutamate —the ...

  13. Basics of tumor development and importance of human papilloma virus (HPV for head and neck cancer [

    Directory of Open Access Journals (Sweden)

    Klussmann, Jens Peter

    2012-12-01

    Full Text Available [english] Head and Neck Squamous Cell Carcinomas (HNSCC are the 6 most common cancers worldwide. While incidence rates for cancer of the hypopharynx and larynx are decreasing, a significant increase in cancer of the oropharynx (OSCC is observed. Classical risk factors for HNSCC are smoking and alcohol. It has been shown for 25 to 60% of OSCC to be associated with an infection by oncogenic human papilloma viruses (HPV. The development of “common” cancer of the head and neck is substantially enhanced by an accumulation of genetic changes, which lead to an inactivation of tumor suppressor genes or activation of proto-oncogenes. A more or less uniform sequence of different DNA-damages leads to genetic instability. In this context, an early and frequent event is deletion on the short arm of chromosome 9, which results in inactivation of the p16-gene. In contrast, for HPV-induced carcinogenesis, expression of the viral proteins E6 and E7 is most important, since they lead to inactivation of the cellular tumor-suppressor-proteins p53 and Rb. The natural route of transoral infection is a matter of debate; peroral HPV-infections might be frequent and disappear uneventfully in most cases. Smoking seems to increase the probability for developing an HPV-associated OSCC. The association of HNSCC with HPV can be proven with established methods in clinical diagnostics. In addition to classical prognostic factors, diagnosis of HPV-association may become important for selection of future therapies. Prognostic relevance of HPV probably surmounts many known risk-factors, for example regional metastasis. Until now, no other molecular markers are established in clinical routine. Future therapy concepts may vary for the two subgroups of patients, particularly patients with HPV-associated OSCC may take advantage of less aggressive treatments. Finally, an outlook will be given on possible targeted therapies.

  14. Expanding General Relativity's Space by S-Denying

    Science.gov (United States)

    Rabounski, Dmitri; Smarandache, Florentins; Borissova, Larissa

    2016-05-01

    Applying the S-denying procedure to signature conditions in a four-dimensional pseudo-Riemannian space - i.e. changing one (or even all) of the conditions to be partially true and partially false. Obtaining five kinds of expanded space-time for General Relativity. Kind I permits the space-time to be in collapse. Kind II permits the space-time to change its own signature. Kind III has peculiarities, linked to the third signature condition. Kind IV permits regions where the metric fully degenerates: there may be non-quantum teleportation, and a home for virtual photons. Kind V is common for kinds I, II, III, and IV.

  15. Human Amniotic Membrane-Derived Products in Sports Medicine: Basic Science, Early Results, and Potential Clinical Applications.

    Science.gov (United States)

    Riboh, Jonathan C; Saltzman, Bryan M; Yanke, Adam B; Cole, Brian J

    2016-09-01

    Amniotic membrane (AM)-derived products have been successfully used in ophthalmology, plastic surgery, and wound care, but little is known about their potential applications in orthopaedic sports medicine. To provide an updated review of the basic science and preclinical and clinical data supporting the use of AM-derived products and to review their current applications in sports medicine. Systematic review. A systematic search of the literature was conducted using the Medline, EMBASE, and Cochrane databases. The search term amniotic membrane was used alone and in conjunction with stem cell, orthopaedic, tissue engineering, scaffold, and sports medicine. The search identified 6870 articles, 80 of which, after screening of the titles and abstracts, were considered relevant to this study. Fifty-five articles described the anatomy, basic science, and nonorthopaedic applications of AM-derived products. Twenty-five articles described preclinical and clinical trials of AM-derived products for orthopaedic sports medicine. Because the level of evidence obtained from this search was not adequate for systematic review or meta-analysis, a current concepts review on the anatomy, physiology, and clinical uses of AM-derived products is presented. Amniotic membranes have many promising applications in sports medicine. They are a source of pluripotent cells, highly organized collagen, antifibrotic and anti-inflammatory cytokines, immunomodulators, and matrix proteins. These properties may make it beneficial when applied as tissue engineering scaffolds, improving tissue organization in healing, and treatment of the arthritic joint. The current body of evidence in sports medicine is heavily biased toward in vitro and animal studies, with little to no human clinical data. Nonetheless, 14 companies or distributors offer commercial AM products. The preparation and formulation of these products alter their biological and mechanical properties, and a thorough understanding of these

  16. Therapy for Cerebral Palsy by Human Umbilical Cord Blood Mesenchymal Stem Cells Transplantation Combined With Basic Rehabilitation Treatment

    Directory of Open Access Journals (Sweden)

    Che Zhang MD

    2015-03-01

    Full Text Available Background. Cerebral palsy (CP is the most common cause leading to childhood disability. Human umbilical cord blood mesenchymal stem cells (hUCB-MSCs transplantation is a promising alternative considering the safety and efficacy in current reports. This report represents a case of hUCB-MSCs transplantation combined with basic rehabilitation treatment beginning as early as age 6 months with follow-up as long as 5 years. Methods. A 6-year-old female patient was diagnosed with CP at age 6 months. The patient accepted 4 infusions of intravenous hUCB-MSCs in each course and received 4 courses of transplantation totally. A series of assessments were performed before the first transplantation, including laboratory tests, CDCC Infant Mental Development Scale, and Gross Motor Function Measure-88 (GMFM-88. Then annual assessments using the GMFM-88, Ashworth spasm assessment, and comprehensive function assessment scale were made in addition to the annual laboratory tests. In addition, electroencephalography and brain magnetic resonance imaging were conducted before transplantation and in the follow-up phase. Rehabilitation and safety follow-up have been ongoing for 5 years up to date. Results. There was no complaint about adverse effects during hospitalization or postoperative follow-up. Motor function recovered to normal level according to the evaluation of scales. Language function improved significantly. Linguistic rehabilitation therapy was enhanced for further improvement. Conclusions. The clinical application of hUC-MSCs combined with basic rehabilitation treatment was effective and safe for improving motor and comprehensive function in a patient with CP.

  17. The perceived temperature - a versatile index for the assessment of the human thermal environment. Part A: scientific basics

    Science.gov (United States)

    Staiger, Henning; Laschewski, Gudrun; Grätz, Angelika

    2012-01-01

    The Perceived Temperature (PT) is an equivalent temperature based on a complete heat budget model of the human body. It has proved its suitability for numerous applications across a wide variety of scales from micro to global and is successfully used both in daily forecasts and climatological studies. PT is designed for staying outdoors and is defined as the air temperature of a reference environment in which the thermal perception would be the same as in the actual environment. The calculation is performed for a reference subject with an internal heat production of 135 W m-2 (who is walking at 4 km h-1 on flat ground). In the reference environment, the mean radiant temperature equals the air temperature and wind velocity is reduced to a slight draught. The water vapour pressure remains unchanged. Under warm/humid conditions, however, it is implicitly related to a relative humidity of 50%. Clothing is adapted in order to achieve thermal comfort. If this is impossible, cold or heat stress will occur, respectively. The assessment of thermal perception by means of PT is based on Fanger's Predicted Mean Vote (PMV) together with additional model extensions taking account of stronger deviations from thermal neutrality. This is performed using a parameterisation based on a two-node model. In the cold, it allows the mean skin temperature to drop below the comfort value. In the heat, it assesses additionally the enthalpy of sweat-moistened skin and of wet clothes. PT has the advantages of being self-explanatory due to its deviation from air temperature and being—via PMV—directly linked to a thermo-physiologically-based scale of thermal perception that is widely used and has stood the test of time. This paper explains in detail the basic equations of the human heat budget and the coefficients of the parameterisations.

  18. Thinking about thinking and emotion: the metacognitive approach to the medical humanities that integrates the humanities with the basic and clinical sciences.

    Science.gov (United States)

    Eichbaum, Quentin G

    2014-01-01

    Medical knowledge in recent decades has grown prodigiously and has outstripped the capacity of the human brain to absorb and understand it all. This burgeoning of knowledge has created a dilemma for medical educators. We can no longer expect students to continue memorizing this large body of increasingly complex knowledge. Instead, our efforts should be redirected at developing in students a competency as flexible thinkers and agile learners so they can adeptly deal with new knowledge, complexity, and uncertainty in a rapidly changing world. Such a competency would entail not only cognitive but also emotional skills essential for the holistic development of their professional identity. This article will argue that metacognition--“thinking about thinking (and emotion)”--offers the most viable path toward developing this competency. The overwhelming volume of medical knowledge has driven some medical schools to reduce the time allocated in their curricula to the “soft-option” humanities as they tend to consider them an expendable “luxury.” Vanderbilt University School of Medicine, Nashville, TN, has moved away from the traditional conception of the medical humanities as “the arts,” composed of art, music, and literature, toward an approach that integrates the humanities with the basic and clinical sciences, based on metacognition. This metacognitive approach to the humanities, described in this article, has three goals: 1) to develop students as flexible thinkers and agile learners and to provide them with essential cognitive and emotional skills for navigating medical complexity and uncertainty; 2) to elicit in students empathy and tolerance by making them aware of the immense diversity in human cognition (and emotion); and 3) to integrate the humanities with the basic and clinical sciences. Through this metacognitive approach, students come to understand their patterns of cognition and emotions, and in the group setting, they learn to mindfully

  19. The 5 Alpha-Reductase Isozyme Family: A Review of Basic Biology and Their Role in Human Diseases

    Directory of Open Access Journals (Sweden)

    Faris Azzouni

    2012-01-01

    Full Text Available Despite the discovery of 5 alpha-reduction as an enzymatic step in steroid metabolism in 1951, and the discovery that dihydrotestosterone is more potent than testosterone in 1968, the significance of 5 alpha-reduced steroids in human diseases was not appreciated until the discovery of 5 alpha-reductase type 2 deficiency in 1974. Affected males are born with ambiguous external genitalia, despite normal internal genitalia. The prostate is hypoplastic, nonpalpable on rectal examination and approximately 1/10th the size of age-matched normal glands. Benign prostate hyperplasia or prostate cancer does not develop in these patients. At puberty, the external genitalia virilize partially, however, secondary sexual hair remains sparse and male pattern baldness and acne develop rarely. Several compounds have been developed to inhibit the 5 alpha-reductase isozymes and they play an important role in the prevention and treatment of many common diseases. This review describes the basic biochemical properties, functions, tissue distribution, chromosomal location, and clinical significance of the 5 alpha-reductase isozyme family.

  20. Asthma Basics

    Science.gov (United States)

    ... Old Feeding Your 1- to 2-Year-Old Asthma Basics KidsHealth > For Parents > Asthma Basics A A ... Asthma Categories en español Asma: aspectos fundamentales About Asthma Asthma is a common lung condition in kids ...

  1. Brain Basics

    Medline Plus

    Full Text Available ... as depression. The Growing Brain Inside the Brain: Neurons & Neural Circuits Neurons are the basic working unit of the brain ... specialized for the function of conducting messages. A neuron has three basic parts: Cell body which includes ...

  2. Fragments Shored against Ruins: Denis Byrne’s Surface Collection

    Directory of Open Access Journals (Sweden)

    Paul Gillen

    2010-09-01

    Full Text Available Denis Byrne’s Surface Collection is a finely written philosophical travelogue, taking the reader on an archaeological tour of South Asia that is also a personal quest and a critique of heritage conservation. Its closely organised structure, reminiscent of baroque music, begins with an investigation of the modes of erasure or preservation of the recent past in South East Asia, shifts to an ironic narrative of futile quests for historical traces, and concludes with reflections on the clash of popular Buddhist relic worship with the values of heritage conservation. Byrne stages the latter conflict as between magical and rationalistic worldviews. Mildly dissenting, this essay suggests that although heritage conservation deploys scientific meanss, it is based on the sacralisation of the past. This motivation brings it closer to magic than to core tenets of Enlightenment, either of the Rational or the Buddhist kind.

  3. Fragments shored against ruins : Denis Byrne’s surface collection

    Directory of Open Access Journals (Sweden)

    Gillen, Paul

    2010-01-01

    Full Text Available Denis Byrne’s Surface Collection is a finely written philosophical travelogue, taking the reader on an archaeological tour of South Asia that is also a personal quest and a critique of heritage conservation. Its closely organised structure, reminiscent of baroque music, begins with an investigation of the modes of erasure or preservation of the recent past in South East Asia, shifts to an ironic narrative of futile quests for historical traces, and concludes with reflections on the clash of popular Buddhist relic worship with the values of heritage conservation. Byrne stages the latter conflict as between magical and rationalistic worldviews. Mildly dissenting, this essay suggests that although heritage conservation deploys scientific meanss, it is based on the sacralisation of the past. This motivation brings it closer to magic than to core tenets of Enlightenment, either of the Rational or the Buddhist kind.

  4. DENIS Observations of Multibeam Galaxies in the Zone of Avoidance

    CERN Document Server

    Schröder, A; Mamon, G A

    1999-01-01

    Roughly 25% of the optical extragalactic sky is obscured by the dust and stars of our Milky Way. Dynamically important structures might still lie hidden in this zone. Various surveys are presently being employed to uncover the galaxy distribution in the Zone of Avoidance (ZOA) but all suffer from (different) limitations and selection effects. We illustrate the promise of using a multi-wavelength approach for extragalactic large-scale studies behind the ZOA, i.e. a combination of three surveys -- optical, systematic blind HI and near-infrared (NIR), which will allow the mapping of the peculiar velocity field in the ZOA through the NIR Tully-Fisher relation. In particular, we present here the results of cross-identifying HI-detected galaxies with the DENIS NIR survey, and the use of NIR colours to determine foreground extinctions.

  5. JEUX DANGEREUX DANS LE THEATRE DE CARLOS DENIS MOLINA?

    OpenAIRE

    Braillon-Chantraine, Cécile

    2014-01-01

    International audience; De par son hyper réflexivité, l'oeuvre dramatique de l'écrivain uruguayen Carlos Denis Molina (1916-1983) constitue un témoignage des pratiques théâtrales de son époque et des mutations socio-économiques que traverse son pays, l'Uruguay, au cours du vingtième siècle. Le procédé méta théâtral du jeu, mettant en scène des personnages en train de se divertir et de jouer un rôle, est présent dans plusieurs de ses pièces, à chaque étape de sa production dramatique, et débou...

  6. The Mode Evolution of Basic Human Rights Principle at Chinese Constitution%基本人权原则在中国宪法中的模式嬗变

    Institute of Scientific and Technical Information of China (English)

    施秀艳

    2011-01-01

    Basic human rights principle is one of the constitution principles. Though each nation's constitution manifestation pattern is different, the basic human rights principle is confirmed in the constitution, so as China's constitution. China's four constitution confirmed the basic human rights principle with the silent and obvious ways. The silent way esperienced the post-roll mode and the pre-roll mode which showed the evolution process of basic human fights at Chinese constitution and revealed the historical process of people's more and more attention in China.%基本人权原则是宪法基本原则之一,虽然各国宪法表现形式不同,但都在宪法中确认了基本人权原则,我国宪法也同样如此.中国四部宪法确认基本人权原则,分别采取了默示型和明示型确认模式,其中默示型确认模式又经历了后置式和前置式两个发展阶段,体现了基本人权原则在中国宪法中的演变过程,也揭示了人权在我国日益受到关注和重视的历史脉络.

  7. 19 CFR 122.66 - Clearance or permission to depart denied.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Clearance or permission to depart denied. 122.66 Section 122.66 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY... Clearance or permission to depart denied. If advance electronic air cargo information is not received...

  8. 76 FR 11756 - Action Affecting Export Privileges; Ali Amirnazmi; Order Denying Export Privileges

    Science.gov (United States)

    2011-03-03

    ... Bureau of Industry and Security Action Affecting Export Privileges; Ali Amirnazmi; Order Denying Export... 766.25 of the Export Administration Regulations (``EAR'' or ``Regulations'') \\1\\ provides, in... the Office of Export Enforcement, may deny the export privileges of any person who has been convicted...

  9. Beyond Maslow's culture-bound linear theory: a preliminary statement of the double-Y model of basic human needs.

    Science.gov (United States)

    Yang, Kuo-Shu

    2003-01-01

    Maslow's theory of basic human needs is criticized with respect to two of its major aspects, unidimensional linearity and cross-cultural validity. To replace Maslow's linear theory, a revised Y model is proposed on the base of Y. Yu's original Y model. Arranged on the stem of the Y are Maslow's physiological needs (excluding sexual needs) and safety needs. Satisfaction of these needs is indispensable to genetic survival. On the left arm of the Y are interpersonal and belongingness needs, esteem needs, and the self-actualization need. The thoughts and behaviors required for the fulfillment of these needs lead to genetic expression. Lastly, on the right arm of the Y are sexual needs, childbearing needs, and parenting needs. The thoughts and behaviors entailed in the satisfaction of these needs result in genetic transmission. I contend that needs for genetic survival and transmission are universal and that needs for genetic expression are culture-bound. Two major varieties of culture-specific expression needs are distinguished for each of the three levels of needs on the left arm of the Y model. Collectivistic needs for interpersonal affiliation and belongingness, esteem, and self-actualization prevail in collectivist cultures like those found in East Asian countries. Individualistic needs are dominant in individualist cultures like those in North America and certain European nations. I construct two separate Y models, one for people in collectivist cultures and the other for those in individualist ones. In the first (the Yc model), the three levels of expression needs on the left arm are collectivistic in nature, whereas in the second (the Yi model), the three levels of needs on the left arm are individualistic in nature. Various forms of the double-Y model are formulated by conceptually combining the Yc and Yi models at the cross-cultural, crossgroup, and intra-individual levels. Research directions for testing the various aspects of the double-Y model are

  10. Pharmacokinetics of recombinant human basic fibroblast growth factor in rabbits and mice serum and rabbits aqueous humor

    Institute of Scientific and Technical Information of China (English)

    Qi ZHANG; Guang-ji WANG; Jian-guo SUN

    2004-01-01

    AIM: To study the pharmacokinetics of recombinant human basic fibroblast growth factor (rhbFGF) in rabbits and mice after iv and postocular administration, and the changes of rhbFGF in rabbits aqueous humor after postocular administration. METHODS: After iv or postocular administration three doses of rhbFGF in rabbits and mice,rhbFGF concentration in serum and rabbit aqueous humor was determined by enzyme-linked immunosorbent .assay. RESULTS: Serum concentration-time data of rabbits after iv administration of rhbFGF 1, 2, and 4 μg/kg were fitted to bi-exponential equations with half-lives of 0.9, 0.9, and 0.6 min for T1/2α and 7, 8, and 4.7 min for T1/2β.Plasma concentration-time data of mice after iv administration of rhbFGF 2.5, 5 and 10 μg/kg were fitted to biexponential equations with half-lives of 0.4, 0.6, and 0.9 min for T1/2α and 6, 5, and 7 min for T1/2β. The AUCs were linearly correlated to doses in both cases (rrabbit=0.997, rmouse=0.999). The serum concentrations of rhbFGF were very low, near to the background after postocular administration of 2 or 5 μg/kg, in both rabbits and mice. The rhbFGF levels in rabbits aqueous humor were higher than control 8 h postdose (P<0.01). CONCLUSION: rhbFGF within the examined doses had a linear pharmacokinetics in rabbits and mice. High concentration of rhbFGF was found in rabbits aqueous humor after postocular administration.

  11. Arecoline increases basic fibroblast growth factor but reduces expression of IL-1, IL-6, G-CSF and GM-CSF in human umbilical vein endothelium.

    Science.gov (United States)

    Ullah, Mafaz; Cox, Stephen; Kelly, Elizabeth; Moore, Malcolm A S; Zoellner, Hans

    2015-09-01

    Areca nut chewing is associated with oral submucous fibrosis (OSF). Raised vascular basic fibroblast growth factor may induce fibrosis. Arecoline is a muscarinic alkaloid in areca nut, which we earlier reported causes injury and necrosis of human endothelium. Human umbilical vein endothelial cells were exposed to arecoline with or without tumor necrosis factor-α, and separately to acetylcholine, muscarine, or nicotine. Protein levels of basic fibroblast growth factor, as well as the inflammatory cytokines: granulocyte colony stimulating factor (G-CSF), granulocyte-macrophage colony stimulating factor, and Interleukins-6, 1-α and 1-β, were determined by enzyme-linked immunosorbent assay. mRNA levels were established by real-time reverse transcription polymerase chain reaction. Basic fibroblast growth factor was released into the culture medium at arecoline levels causing necrosis (P arecoline on levels of the inflammatory cytokines (P arecoline reduced this stimulated expression (P Arecoline had no effect on mRNA for basic fibroblast growth factor, although there was reduced mRNA for the separate inflammatory cytokines studied. The effect of acetylcholine, muscarine, and nicotine was minimal and dissimilar to that of arecoline. Data raise the possibility that arecoline-induced, vascular basic fibroblast growth factor contributes to OSF, by combining increased growth factor expression with endothelial necrosis, and thus driving fibroblast proliferation. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  12. Interaction between the C-terminal region of human myelin basic protein and calmodulin: analysis of complex formation and solution structure.

    Science.gov (United States)

    Majava, Viivi; Petoukhov, Maxim V; Hayashi, Nobuhiro; Pirilä, Päivi; Svergun, Dmitri I; Kursula, Petri

    2008-02-19

    The myelin sheath is a multilamellar membrane structure wrapped around the axon, enabling the saltatory conduction of nerve impulses in vertebrates. Myelin basic protein, one of the most abundant myelin-specific proteins, is an intrinsically disordered protein that has been shown to bind calmodulin. In this study, we focus on a 19-mer synthetic peptide from the predicted calmodulin-binding segment near the C-terminus of human myelin basic protein. The interaction of native human myelin basic protein with calmodulin was confirmed by affinity chromatography. The binding of the myelin basic protein peptide to calmodulin was tested with isothermal titration calorimetry (ITC) in different temperatures, and Kd was observed to be in the low muM range, as previously observed for full-length myelin basic protein. Surface plasmon resonance showed that the peptide bound to calmodulin, and binding was accompanied by a conformational change; furthermore, gel filtration chromatography indicated a decrease in the hydrodynamic radius of calmodulin in the presence of the peptide. NMR spectroscopy was used to map the binding area to reside mainly within the hydrophobic pocket of the C-terminal lobe of calmodulin. The solution structure obtained by small-angle X-ray scattering indicates binding of the myelin basic protein peptide into the interlobal groove of calmodulin, while calmodulin remains in an extended conformation. Taken together, our results give a detailed structural insight into the interaction of calmodulin with a C-terminal segment of a major myelin protein, the myelin basic protein. The used 19-mer peptide interacts mainly with the C-terminal lobe of calmodulin, and a conformational change accompanies binding, suggesting a novel mode of calmodulin-target protein interaction. Calmodulin does not collapse and wrap around the peptide tightly; instead, it remains in an extended conformation in the solution structure. The observed affinity can be physiologically relevant

  13. Interaction between the C-terminal region of human myelin basic protein and calmodulin: analysis of complex formation and solution structure

    Directory of Open Access Journals (Sweden)

    Hayashi Nobuhiro

    2008-02-01

    Full Text Available Abstract Background The myelin sheath is a multilamellar membrane structure wrapped around the axon, enabling the saltatory conduction of nerve impulses in vertebrates. Myelin basic protein, one of the most abundant myelin-specific proteins, is an intrinsically disordered protein that has been shown to bind calmodulin. In this study, we focus on a 19-mer synthetic peptide from the predicted calmodulin-binding segment near the C-terminus of human myelin basic protein. Results The interaction of native human myelin basic protein with calmodulin was confirmed by affinity chromatography. The binding of the myelin basic protein peptide to calmodulin was tested with isothermal titration calorimetry (ITC in different temperatures, and Kd was observed to be in the low μM range, as previously observed for full-length myelin basic protein. Surface plasmon resonance showed that the peptide bound to calmodulin, and binding was accompanied by a conformational change; furthermore, gel filtration chromatography indicated a decrease in the hydrodynamic radius of calmodulin in the presence of the peptide. NMR spectroscopy was used to map the binding area to reside mainly within the hydrophobic pocket of the C-terminal lobe of calmodulin. The solution structure obtained by small-angle X-ray scattering indicates binding of the myelin basic protein peptide into the interlobal groove of calmodulin, while calmodulin remains in an extended conformation. Conclusion Taken together, our results give a detailed structural insight into the interaction of calmodulin with a C-terminal segment of a major myelin protein, the myelin basic protein. The used 19-mer peptide interacts mainly with the C-terminal lobe of calmodulin, and a conformational change accompanies binding, suggesting a novel mode of calmodulin-target protein interaction. Calmodulin does not collapse and wrap around the peptide tightly; instead, it remains in an extended conformation in the solution structure

  14. Basic electrotechnology

    CERN Document Server

    Ashen, R A

    2013-01-01

    BASIC Electrotechnology discusses the applications of Beginner's All-purpose Symbolic Instruction Code (BASIC) in engineering, particularly in solving electrotechnology-related problems. The book is comprised of six chapters that cover several topics relevant to BASIC and electrotechnology. Chapter 1 provides an introduction to BASIC, and Chapter 2 talks about the use of complex numbers in a.c. circuit analysis. Chapter 3 covers linear circuit analysis with d.c. and sinusoidal a.c. supplies. The book also discusses the elementary magnetic circuit theory. The theory and performance of two windi

  15. Brain Basics

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    Full Text Available ... Basics will introduce you to some of this science, such as: How the brain develops How genes and the environment affect the brain The basic structure of the brain How different parts of the brain communicate and work with each other How changes in the brain ...

  16. Brain Basics

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    Full Text Available ... pituitary-adrenal (HPA) axis. Brain Basics in Real Life Brain Basics in Real Life—How Depression affects the Brain Meet Sarah Sarah ... having trouble coping with the stresses in her life. She began to think of suicide because she ...

  17. Activity of human kallikrein-related peptidase 6 (KLK6) on substrates containing sequences of basic amino acids. Is it a processing protease?

    Science.gov (United States)

    Silva, Roberta N; Oliveira, Lilian C G; Parise, Carolina B; Oliveira, Juliana R; Severino, Beatrice; Corvino, Angela; di Vaio, Paola; Temussi, Piero A; Caliendo, Giuseppe; Santagada, Vincenzo; Juliano, Luiz; Juliano, Maria A

    2017-05-01

    Human kallikrein 6 (KLK6) is highly expressed in the central nervous system and with elevated level in demyelinating disease. KLK6 has a very restricted specificity for arginine (R) and hydrolyses myelin basic protein, protein activator receptors and human ionotropic glutamate receptor subunits. Here we report a previously unreported activity of KLK6 on peptides containing clusters of basic amino acids, as in synthetic fluorogenic peptidyl-Arg-7-amino-4-carbamoylmethylcoumarin (peptidyl-ACC) peptides and FRET peptides in the format of Abz-peptidyl-Q-EDDnp (where Abz=ortho-aminobenzoic acid and Q-EDDnp=glutaminyl-N-(2,4-dinitrophenyl) ethylenediamine), in which pairs or sequences of basic amino acids (R or K) were introduced. Surprisingly, KLK6 hydrolyzed the fluorogenic peptides Bz-A-R(↓)R-ACC and Z-R(↓)R-MCA between the two R groups, resulting in non-fluorescent products. FRET peptides containing furin processing sequences of human MMP-14, nerve growth factor (NGF), Neurotrophin-3 (NT-3) and Neurotrophin-4 (NT-4) were cleaved by KLK6 at the same position expected by furin. Finally, KLK6 cleaved FRET peptides derived from human proenkephalin after the KR, the more frequent basic residues flanking enkephalins in human proenkephalin sequence. This result suggests the ability of KLK6 to release enkephalin from proenkephalin precursors and resembles furin a canonical processing proteolytic enzyme. Molecular models of peptides were built into the KLK6 structure and the marked preference of the cut between the two R of the examined peptides was related to the extended conformation of the substrates. Copyright © 2017 Elsevier B.V. All rights reserved.

  18. The DENIS Point Source Catalogue towards the Magellanic Clouds

    CERN Document Server

    Cioni, M R L; Habing, H J; Fouqué, P; Bertin, E; Deul, E; Egret, D; Alard, C; De Batz, B; Borsenberger, J; Dennefeld, M; Epchtein, N; Forveille, T; Garzón, F; Hron, J; Kimeswenger, S; Lacombe, F; Le Bertre, T; Mamon, G A; Omont, A; Paturel, G; Persi, P; Robin, A; Rouan, D; Simon, G; Tiphene, D; Vauglin, I; Wagner, S

    2000-01-01

    We have compiled the near infrared Point Source Catalogue (PSC) towards the Magellanic Clouds (MCs) extracted from the data obtained with the Deep Near Infrared Survey of the Southern Sky - DENIS (Epchtein et al. 1997). The catalogue covers an area of of 19.87* 16 square degrees centered on (RA, DEC)=(5h27m20s, -69o00'00'') for the Large Magellanic Cloud (LMC) and 14.7* 10 square degrees centered on (RA, DEC)=(h02m40s, -73o00'00'' for the Small Magellanic Cloud (SMC) at the epoch J2000. It contains about 1300000 sources towards the LMC and 300000 sources towards the SMC each detected in at least 2 of the 3 photometric bands involved in the survey (I, J, Ks). 700f the detected sources are true members of the Magellanic Clouds, respectively and consist mainly of red giants, asymptotic giant branch stars and super-giants. The observations have all been made with the same instrument and the data have been calibrated and reduced uniformly. The catalogue provides a homogeneous set of photometric data.

  19. Passive optical sensing of atmospheric polarization for GPS denied operations

    Science.gov (United States)

    Aycock, Todd; Lompado, Art; Wolz, Troy; Chenault, David

    2016-05-01

    There is a rapidly growing need for position, navigation, and timing (PNT) capability that remains effective when GPS is degraded or denied. Naturally occurring sky polarization was used as long ago as the Vikings for navigation purposes. With current polarimetric sensors, the additional polarization information measured by these sensors can be used to increase the accuracy and the availability of this technique. The Sky Polarization Azimuth Sensing System (SkyPASS) sensor measures this naturally occurring sky polarization to give absolute heading information to less than 0.1° and offers significant performance enhancement over digital compasses and sun sensors. SkyPASS has been under development for some time for terrestrial applications, but use above the atmosphere may be possible and the performance specifications and SWAP are attractive for use as an additional pose sensor on a satellite. In this paper, we will describe the phenomenology, the sensor performance, and the latest test results of terrestrial SkyPASS; we will also discuss the potential for use above the atmosphere and the expected benefits and limitations.

  20. Denis Diderot on War and Peace: Nature and Morality

    Directory of Open Access Journals (Sweden)

    Whitney Mannies

    2014-01-01

    Full Text Available Las ideas de Denis Diderot sobre la guerra y la paz revelan muchos de las contradiciones que el identificó en el mundo. Por un lado, la guerra es un producto natural de contradiciones entre la ley de la natura y las instituciones humanas. Por otro lado, siempre debe ser sometido a juicio moral basado en conocimiento amplia de la historia y contexto. La guerra puede ser buena si derota a la tiranía, y mala si limita a la libertad e igualdad. La paz puede ser buena si aumenta a la libertad, la igualdad, y la prosperidad, y mala si mantiene la desigualdad. Diderot nunca se permite juicios universales por todos los tiempos y todos los sitios, pero insista en comparaciones y contrastes sin fin entre el mundo moral y el mundo natural. El materialismo filosófico es el fundamento de su manera de entender el mundo, pero los aspectos morales son sus instrumentos de juicio.

  1. Gps-Denied Geo-Localisation Using Visual Odometry

    Science.gov (United States)

    Gupta, Ashish; Chang, Huan; Yilmaz, Alper

    2016-06-01

    The primary method for geo-localization is based on GPS which has issues of localization accuracy, power consumption, and unavailability. This paper proposes a novel approach to geo-localization in a GPS-denied environment for a mobile platform. Our approach has two principal components: public domain transport network data available in GIS databases or OpenStreetMap; and a trajectory of a mobile platform. This trajectory is estimated using visual odometry and 3D view geometry. The transport map information is abstracted as a graph data structure, where various types of roads are modelled as graph edges and typically intersections are modelled as graph nodes. A search for the trajectory in real time in the graph yields the geo-location of the mobile platform. Our approach uses a simple visual sensor and it has a low memory and computational footprint. In this paper, we demonstrate our method for trajectory estimation and provide examples of geolocalization using public-domain map data. With the rapid proliferation of visual sensors as part of automated driving technology and continuous growth in public domain map data, our approach has the potential to completely augment, or even supplant, GPS based navigation since it functions in all environments.

  2. RADIKALISIERUNGSPROZESSE WESTLICHER DSCHIHADISTEN. EINE UNTERSUCHUNG AM BEISPIEL DENIS CUSPERT

    Directory of Open Access Journals (Sweden)

    Niklas Palm

    2017-03-01

    Full Text Available Diese Arbeit setzt sich mit der Frage auseinander, wie sich westliche Dschihadisten radikalisieren und welche konkreten Faktoren dazu beitragen können. Anhand theoretisch ausgearbeiteter Modelle, soll der Frage am konkreten Beispiel Denis Cuspert nachgegangen werden. Aufgrund der Brisanz des Themas, allein in der Bundesrepublik sind in den letzten Jahren über 850 Personen nach Syrien oder in den Irak ausgereist, liegt die Notwendigkeit einer Auseinandersetzung mit dessen Hintergründen nahe. Gerade hinsichtlich Cuspert, dem die Sicherheitsbehörden ein erhebliches Mobilisierungs- und Gefahrenpotential zusprechen, wurden bisher vor allem nicht-akademische Beiträge gewidmet, weshalb diese Arbeit den Anspruch erhebt, diese zu sammeln und den Radikalisierungsprozess Cusperts in einer theoriegeleiteten, empirischen Untersuchung darzulegen. Die Ergebnisse spiegeln, wie in der Forschung zur Radikalisierung vielfach ersichtlich wird, die Vielschichtigkeit des Prozesses wieder. So sind es, wie so oft, persönliche Krisen und Diskriminierungserfahrungen, Identitätsprobleme, Einflüsse extremistischer Bewegungen sowie Narrative dass der Westen einen Krieg gegen den Islam führt, die letztlich dazu führen, dass er in den Dschihad zieht. Was der Fall Cuspert aber auch lehrt ist, dass sich vor allem aufgrund von individueller Charakteristika erklären lässt, warum in fundamentalistischen Kreisen manch einer zur Waffe greift und ein anderer nicht.

  3. Basic hydraulics

    CERN Document Server

    Smith, P D

    1982-01-01

    BASIC Hydraulics aims to help students both to become proficient in the BASIC programming language by actually using the language in an important field of engineering and to use computing as a means of mastering the subject of hydraulics. The book begins with a summary of the technique of computing in BASIC together with comments and listing of the main commands and statements. Subsequent chapters introduce the fundamental concepts and appropriate governing equations. Topics covered include principles of fluid mechanics; flow in pipes, pipe networks and open channels; hydraulic machinery;

  4. Autocalibrating vision guided navigation of unmanned air vehicles via tactical monocular cameras in GPS denied environments

    Science.gov (United States)

    Celik, Koray

    This thesis presents a novel robotic navigation strategy by using a conventional tactical monocular camera, proving the feasibility of using a monocular camera as the sole proximity sensing, object avoidance, mapping, and path-planning mechanism to fly and navigate small to medium scale unmanned rotary-wing aircraft in an autonomous manner. The range measurement strategy is scalable, self-calibrating, indoor-outdoor capable, and has been biologically inspired by the key adaptive mechanisms for depth perception and pattern recognition found in humans and intelligent animals (particularly bats), designed to assume operations in previously unknown, GPS-denied environments. It proposes novel electronics, aircraft, aircraft systems, systems, and procedures and algorithms that come together to form airborne systems which measure absolute ranges from a monocular camera via passive photometry, mimicking that of a human-pilot like judgement. The research is intended to bridge the gap between practical GPS coverage and precision localization and mapping problem in a small aircraft. In the context of this study, several robotic platforms, airborne and ground alike, have been developed, some of which have been integrated in real-life field trials, for experimental validation. Albeit the emphasis on miniature robotic aircraft this research has been tested and found compatible with tactical vests and helmets, and it can be used to augment the reliability of many other types of proximity sensors.

  5. The simultaneous identification of metoprolol and its major acidic and basic metabolites in human urine by gas chromatography-mass spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Li, Feng; Cooper, S.F. [Universite du Quebec, Pointe-Claire (Canada)

    1996-12-31

    A novel gas chromatography-mass spectrometric (GC-MS) method was developed to confirm and identify metoprolol and its metabolites by double derivatization with S-(-)menthyl chloroformate [(-)-MCF] and N-methyl(trimethylsilyl-trifluoroacetamide) (MSTFA). This is the first report, which describes the simultaneous identification of metoprolol, its one major acidc and other basic metabolites in human urine based on solid-phase extraction with C{sub 18} reversed-phase cartridges. 12 refs., 4 figs.

  6. Brain Basics

    Medline Plus

    Full Text Available ... in the anatomy, physiology, and chemistry of the nervous system. When the brain cannot effectively coordinate the billions ... the basic working unit of the brain and nervous system. These cells are highly specialized for the function ...

  7. Brain Basics

    Medline Plus

    Full Text Available ... effectively coordinate the billions of cells in the body, the results can affect many aspects of life. ... messages. A neuron has three basic parts: Cell body which includes the nucleus, cytoplasm, and cell organelles. ...

  8. Brain Basics

    Medline Plus

    Full Text Available ... science, such as: How the brain develops How genes and the environment affect the brain The basic ... that with brain development in people mental disorders. Genes and environmental cues both help to direct this ...

  9. Brain Basics

    Medline Plus

    Full Text Available ... Life Brain Basics in Real Life—How Depression affects the Brain Meet Sarah Sarah is a middle- ... harder for Sarah to recover normally from her low mood. It's important to remember that everyone gets " ...

  10. Brain Basics

    Medline Plus

    Full Text Available ... in the anatomy, physiology, and chemistry of the nervous system. When the brain cannot effectively coordinate the billions ... the basic working unit of the brain and nervous system. These cells are highly specialized for the function ...

  11. Brain Basics

    Medline Plus

    Full Text Available ... science, such as: How the brain develops How genes and the environment affect the brain The basic ... that with brain development in people mental disorders. Genes and environmental cues both help to direct this ...

  12. Basic Finance

    Science.gov (United States)

    Vittek, J. F.

    1972-01-01

    A discussion of the basic measures of corporate financial strength, and the sources of the information is reported. Considered are: balance sheet, income statement, funds and cash flow, and financial ratios.

  13. Brain Basics

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    Full Text Available ... Real Life Brain Basics in Real Life—How Depression affects the Brain Meet Sarah Sarah is a ... blues" from time to time. In contrast, major depression is a serious disorder that lasts for weeks. ...

  14. Brain Basics

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    Full Text Available ... normal brain development and function can go awry, leading to mental illnesses. Brain Basics will introduce you ... of DNA. Sometimes this copying process is imperfect, leading to a gene mutation that causes the gene ...

  15. Brain Basics

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    Full Text Available ... News About Us Home > Health & Education > Educational Resources Brain Basics Introduction The Growing Brain The Working Brain ... to mental disorders, such as depression. The Growing Brain Inside the Brain: Neurons & Neural Circuits Neurons are ...

  16. Brain Basics

    Science.gov (United States)

    ... News About Us Home > Health & Education > Educational Resources Brain Basics Introduction The Growing Brain The Working Brain ... to mental disorders, such as depression. The Growing Brain Inside the Brain: Neurons & Neural Circuits Neurons are ...

  17. Brain Basics

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    Full Text Available ... related to changes in the anatomy, physiology, and chemistry of the nervous system. When the brain cannot ... How the brain develops How genes and the environment affect the brain The basic structure of the ...

  18. Brain Basics

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    Full Text Available ... Real Life Brain Basics in Real Life—How Depression affects the Brain Meet Sarah Sarah is a ... blues" from time to time. In contrast, major depression is a serious disorder that lasts for weeks. ...

  19. SARS Basics

    Science.gov (United States)

    ... and Resources Related Links Clinician Registry Travelers' Health SARS Basics Fact Sheet Language: English Español (Spanish) Format: ... 3 pages] SARS [3 pages] SARS [3 pages] SARS? Severe acute respiratory syndrome (SARS) is a viral ...

  20. Brain Basics

    Medline Plus

    Full Text Available ... depression. The Growing Brain Inside the Brain: Neurons & Neural Circuits Neurons are the basic working unit of ... but sometimes give rise to disabilities or diseases. neural circuit —A network of neurons and their interconnections. ...

  1. Brain Basics

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    Full Text Available ... healthy people, and how normal brain development and function can go awry, leading to mental illnesses. Brain ... system. These cells are highly specialized for the function of conducting messages. A neuron has three basic ...

  2. Brain Basics

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    Full Text Available ... Events About Us Home > Health & Education > Educational Resources Brain Basics Introduction The Growing Brain The Working Brain ... to mental disorders, such as depression. The Growing Brain Inside the Brain: Neurons & Neural Circuits Neurons are ...

  3. Brain Basics

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    Full Text Available ... the anatomy, physiology, and chemistry of the nervous system. When the brain cannot effectively coordinate the billions ... basic working unit of the brain and nervous system. These cells are highly specialized for the function ...

  4. Brain Basics

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    Full Text Available ... How the brain develops How genes and the environment affect the brain The basic structure of the ... inside contents of the cell from its surrounding environment and controls what enters and leaves the cell, ...

  5. Using CHAINS, a QuickBASIC 4.5 Program, to Teach Single-Subject Experimentation with Humans

    Science.gov (United States)

    Dermer, Marshall Lev

    2004-01-01

    Students enrolled in a single-subject design course studied the repeated acquisition of response sequences by using CHAINS, a QuickBASIC 4.5 program, which runs in DOS or Windows. For about 2 months, students examined the learning of such sequences as a function of various treatments. Each week students graphed their data, discussed their…

  6. Basic Tilted Helix Bundle – A new protein fold in human FKBP25/FKBP3 and HectD1

    Energy Technology Data Exchange (ETDEWEB)

    Helander, Sara; Montecchio, Meri [Department of Physics, Chemistry and Biology, Division of Chemistry, Linköping University, SE-58183 Linköping (Sweden); Lemak, Alexander [Princess Margaret Cancer Centre and Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 1L7 (Canada); Northeast Structural Genomics Consortium, Toronto, Ontario (Canada); Farès, Christophe [Princess Margaret Cancer Centre and Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 1L7 (Canada); Almlöf, Jonas [Department of Physics, Chemistry and Biology, Division of Chemistry, Linköping University, SE-58183 Linköping (Sweden); Li, Yanjun [Structural Genomics Consortium, University of Toronto, 101 College St, Toronto, Ontario M5G 1L7 (Canada); Yee, Adelinda [Princess Margaret Cancer Centre and Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 1L7 (Canada); Northeast Structural Genomics Consortium, Toronto, Ontario (Canada); Arrowsmith, Cheryl H. [Princess Margaret Cancer Centre and Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 1L7 (Canada); Northeast Structural Genomics Consortium, Toronto, Ontario (Canada); Structural Genomics Consortium, University of Toronto, 101 College St, Toronto, Ontario M5G 1L7 (Canada); Dhe-Paganon, Sirano [Structural Genomics Consortium, University of Toronto, 101 College St, Toronto, Ontario M5G 1L7 (Canada); Sunnerhagen, Maria, E-mail: maria.sunnerhagen@liu.se [Department of Physics, Chemistry and Biology, Division of Chemistry, Linköping University, SE-58183 Linköping (Sweden)

    2014-04-25

    Highlights: • We describe the structure of a novel fold in FKBP25 and HectD. • The new fold is named the Basic Tilted Helix Bundle (BTHB) domain. • A conserved basic surface patch is presented, suggesting a functional role. - Abstract: In this paper, we describe the structure of a N-terminal domain motif in nuclear-localized FKBP25{sub 1–73}, a member of the FKBP family, together with the structure of a sequence-related subdomain of the E3 ubiquitin ligase HectD1 that we show belongs to the same fold. This motif adopts a compact 5-helix bundle which we name the Basic Tilted Helix Bundle (BTHB) domain. A positively charged surface patch, structurally centered around the tilted helix H4, is present in both FKBP25 and HectD1 and is conserved in both proteins, suggesting a conserved functional role. We provide detailed comparative analysis of the structures of the two proteins and their sequence similarities, and analysis of the interaction of the proposed FKBP25 binding protein YY1. We suggest that the basic motif in BTHB is involved in the observed DNA binding of FKBP25, and that the function of this domain can be affected by regulatory YY1 binding and/or interactions with adjacent domains.

  7. Bayesian statistics and information fusion for GPS-denied navigation

    Science.gov (United States)

    Copp, Brian Lee

    It is well known that satellite navigation systems are vulnerable to disruption due to jamming, spoofing, or obstruction of the signal. The desire for robust navigation of aircraft in GPS-denied environments has motivated the development of feature-aided navigation systems, in which measurements of environmental features are used to complement the dead reckoning solution produced by an inertial navigation system. Examples of environmental features which can be exploited for navigation include star positions, terrain elevation, terrestrial wireless signals, and features extracted from photographic data. Feature-aided navigation represents a particularly challenging estimation problem because the measurements are often strongly nonlinear, and the quality of the navigation solution is limited by the knowledge of nuisance parameters which may be difficult to model accurately. As a result, integration approaches based on the Kalman filter and its variants may fail to give adequate performance. This project develops a framework for the integration of feature-aided navigation techniques using Bayesian statistics. In this approach, the probability density function for aircraft horizontal position (latitude and longitude) is approximated by a two-dimensional point mass function defined on a rectangular grid. Nuisance parameters are estimated using a hypothesis based approach (Multiple Model Adaptive Estimation) which continuously maintains an accurate probability density even in the presence of strong nonlinearities. The effectiveness of the proposed approach is illustrated by the simulated use of terrain referenced navigation and wireless time-of-arrival positioning to estimate a reference aircraft trajectory. Monte Carlo simulations have shown that accurate position estimates can be obtained in terrain referenced navigation even with a strongly nonlinear altitude bias. The integration of terrain referenced and wireless time-of-arrival measurements is described along with

  8. 8 CFR 245a.6 - Treatment of denied application under part 245a, Subpart B.

    Science.gov (United States)

    2010-01-01

    ... Act of 1986 (IRCA) Legalization Provisions § 245a.6 Treatment of denied application under part 245a... to temporary resident status, the LIFE Legalization application shall be deemed converted to...

  9. Carbon now real factor in denying permits to coal-based generation

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2009-01-15

    Concerns about global climate change and uncertainties about the potential cost of carbon regulation have increased the odds that applications to build coal-fired plants will be denied. In Kansas the coal industry was stunned by the denial of an air-quality permit for a project because of concerns about global warming. It was the first time any official anywhere had invoked greenhouse gases as the reason for denying an operating permit for a proposed fossil-fueled plant.

  10. The Basic Forms That Education Returns to Humanity%试论教育回归人性的基本方式

    Institute of Scientific and Technical Information of China (English)

    涂艳国; 周贵礼

    2012-01-01

    To revive the humanity of education is basically a concept that starts with making use of the genuineness in humanity to bring out the goodness in humanity, helps human beings experience their lives to the fullest extent, and achieves the integration of genuineness, goodness and virtue. The basic approach for educational theory to return to humanity is a full scale command of the basis on which how humanity and education mean to each other and how they play their roles in real life. The revival of humanity in education involves the aspects of educational theories and educational practices. It is believed that education should be given fundamental, basic and overall theoretical and valuable guidance, so that education would have more respect for humanity, make better use of humanity and bring itself closer to humanity, and to the end, it would breed humanity to develop into a certain kind of desired status in the best possible way. The basic approach for educational activity to return to humanity is to embark on a journey that pursues the trueness, virtue and wisdom. It means that we should respect humanity, press close to the true existence of humanity the real life, improve and upgrade humanity in a perfect and benign way, so that we can completely possess the intellectual quality by the full force of education, to the extent that rational wisdom, value wisdom and practical wisdom could be blended into one, and complete our quest for experiencing lives to fullest.%教育回归人性,指教育要基于与利用人性之真,达成人性之善,促成人完满的生命体验,实现真、善、美的统一。教育理论回归人性的基本方式,是在全面把握人性与教育的相互意义及其现实表现的基础上,给予教育根本性、基础性、总体性的理论指导与价值引领,让教育更加尊重人性、更好地利用人性、更合乎人性,让人性在教育的作用下尽可能地向某种理想状态发展。教育活动

  11. Outcome of mechanically ventilated patients initially denied admission to an intensive care unit and subsequently admitted.

    Science.gov (United States)

    Naser, Wasim; Schwartz, Naama; Finkelstein, Richard; Bisharat, Naiel

    2016-11-01

    The outcome of mechanically ventilated patients initially denied admission to an intensive care unit (ICU) and subsequently admitted is unclear. We compared outcomes of patients denied ICU admission and subsequently admitted, to those of patients admitted to the ICU and to patients refused ICU admission. The medical records of all the patients who were subjected to mechanical ventilation for at least 24h over a 4year period (2010-2014) were reviewed. Of 707 patients (757 admissions), 124 (18%) were initially denied ICU admission and subsequently admitted. Multivariate stepwise logistic regression analysis showed significant association with death of: age, length of stay, nursing home residency, duration of mechanical ventilation, previous admission with mechanical ventilation, cause for mechanical ventilation, rate of failed extubations, associated morbidity (previous cerebrovascular accident, dementia, chronic renal failure), and occurrence of nosocomial bacteremia. The odds for death among patients denied ICU admission and subsequently transferred to the ICU compared to patients admitted directly to the ICU was 3.6 (95% CI: 1.9-6.7) (Padmission compared to those who were initially denied and subsequently admitted were not statistically significant (OR=1.7, 95% CI: 0.8-3.8). In conclusion, patients denied ICU admission and subsequently admitted face a considerable risk of morbidity and mortality. Their odds of death are nearly three times those admitted directly to the ICU. Late admission to the ICU does not appear to provide benefit compared to patients who remain in general medicine wards.

  12. Basic electronics

    CERN Document Server

    Holbrook, Harold D

    1971-01-01

    Basic Electronics is an elementary text designed for basic instruction in electricity and electronics. It gives emphasis on electronic emission and the vacuum tube and shows transistor circuits in parallel with electron tube circuits. This book also demonstrates how the transistor merely replaces the tube, with proper change of circuit constants as required. Many problems are presented at the end of each chapter. This book is comprised of 17 chapters and opens with an overview of electron theory, followed by a discussion on resistance, inductance, and capacitance, along with their effects on t

  13. BASIC ACTIVITIES OF THE HUMAN RESOURCE MANAGEMENT IN ENSURING STAFF FOR S.C. ROMLUX S.A.

    Directory of Open Access Journals (Sweden)

    SECARĂ CARMEN-GABRIELA

    2014-08-01

    Full Text Available Within the analysis conducted, the main activities in the field of human resource management has been assessed, such as: human resource planning; recruitment and selection of staff; assessment of individual professional performances; initial and continuing training; evaluation of human resources management costs; motivation. However, there have also been reviewed with a lower degree of detailing, other issues of interest, such as: human resources assessment; promotion of staff. Following the integration of conclusions of analysis conducted for the business areas listed, it resulted the picture of the most important elements with generalizing value.

  14. Brain Basics

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    Full Text Available ... PFC are involved in using short-term or "working" memory and in retrieving long-term memories. This area ... neuron —A nerve cell that is the basic, working unit of the brain and nervous ... serotonin —A neurotransmitter that regulates many functions, including ...

  15. Brain Basics

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    Full Text Available ... such as depression. The Growing Brain Inside the Brain: Neurons & Neural Circuits Neurons are the basic working unit ... final destination. Chemical signals from other cells guide neurons in forming various brain structures. Neighboring neurons make connections with each other ...

  16. Brain Basics

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    Full Text Available ... Join A Study News & Events News & Events Home Science News Events Multimedia Social Media Press Resources Newsletters NIMH News Feeds About Us About Us Home About the Director Advisory Boards and Groups Strategic ... Basics will introduce you to some of this science, such as: How the brain develops How genes ...

  17. Ethanol Basics

    Energy Technology Data Exchange (ETDEWEB)

    None

    2015-01-30

    Ethanol is a widely-used, domestically-produced renewable fuel made from corn and other plant materials. More than 96% of gasoline sold in the United States contains ethanol. Learn more about this alternative fuel in the Ethanol Basics Fact Sheet, produced by the U.S. Department of Energy's Clean Cities program.

  18. Brain Basics

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    Full Text Available ... are sent from one neuron to another. Share Science News How DNA Shapes Human Gene Expression NIMH ... human volunteers PubMed Central: An archive of life sciences journals NIH Research Fact Sheets NIH Office of ...

  19. Wavelet basics

    CERN Document Server

    Chan, Y T

    1995-01-01

    Since the study of wavelets is a relatively new area, much of the research coming from mathematicians, most of the literature uses terminology, concepts and proofs that may, at times, be difficult and intimidating for the engineer. Wavelet Basics has therefore been written as an introductory book for scientists and engineers. The mathematical presentation has been kept simple, the concepts being presented in elaborate detail in a terminology that engineers will find familiar. Difficult ideas are illustrated with examples which will also aid in the development of an intuitive insight. Chapter 1 reviews the basics of signal transformation and discusses the concepts of duals and frames. Chapter 2 introduces the wavelet transform, contrasts it with the short-time Fourier transform and clarifies the names of the different types of wavelet transforms. Chapter 3 links multiresolution analysis, orthonormal wavelets and the design of digital filters. Chapter 4 gives a tour d'horizon of topics of current interest: wave...

  20. Is inclusive education a human right?

    Science.gov (United States)

    Gordon, John-Stewart

    2013-01-01

    In this article, I question the general idea that inclusive education--i.e., to teach all students in one class--is a moral human right. The following discussion shows that the widespread view in disability studies that there is a moral human right to inclusive education can be reasonably called into question by virtue of the proposed counter arguments, but without denying that inclusive education is of utmost importance. Practically speaking, the legal human right to inclusive education is of great practical value for impaired students, and for their basic right to be free from discrimination in education, since their concern thereby gains great legal and moral force. But, theoretically speaking, this particular human right lacks an attainable consensus concerning proper moral justification. © 2013 American Society of Law, Medicine & Ethics, Inc.

  1. Denys Lasdun and the project for the University of East Anglia

    Directory of Open Access Journals (Sweden)

    Patricia de Diego Ruiz

    2015-05-01

    Full Text Available AbstractThe work of Denys Lasdun has been traditionally valued by its great spatial quality, its elegance and its capacity to develop a new formal tectonic language. Nevertheless, Alvin Boyarsky defi ned Lasdun’s architecture as an architecture of etcetera, implying that his projects were conceptually complex, full of nuances and meanings, and with an important affi liation to the natural world. Following the appreciation, we will study the project of East Anglia University in Norwich as an epitome of one important hidden objective that guided the genealogy and social aims of some remarkable works of the English architect.Far beyond the biological analogy, we will analyze that Lasdun’s interest in natural processes transcends the usual positivist and scientifi c frame. His understanding of the links and resonances of architecture with Nature, comprehend also the human and social sphere. It is the broader concept of life the one that shapes an intuitive, free and holistic view of the Lasdun’s postwar architecture. Being also aware of the raise of the organic discourse that arises in England with the important impulse of Bruno Zevi, Lasdun fuses both sources as a counterpoint to the most academic and conformist practice with the pragmatic necessities and social realities.This way, he manages to develop a personal discourse and lexicon that imprints his projects of the fifties and sixties, and culminates with the University of East Anglia as a proto-organism. Through this project and some earlier works deeply related to it, Lasdun investigates formal and structural possibilities to think the work of architecture as a non-closed system, capable of growth and change; as an inconclusive and adaptable statement ready to be responsive to circumstances, goals, and human needs and aims.

  2. The Health and Social Isolation of American Veterans Denied Veterans Affairs Disability Compensation.

    Science.gov (United States)

    Fried, Dennis Adrian; Passannante, Marian; Helmer, Drew; Holland, Bart K; Halperin, William E

    2017-02-01

    Authors comparatively analyzed health and social isolation between U.S. military veterans denied Veterans Affairs (VA) disability compensation and veterans awarded VA disability compensation. The 2001 National Survey of Veterans was used to create a sample of 4,522 veterans denied or awarded VA disability compensation. Using the Andersen health services utilization model as a conceptual framework, multivariate logistic regression was applied to assess relationships between VA disability compensation award status, three separate domains of health, and correlates of social isolation. Results indicate that denied applicants were more likely than those awarded to have poor overall health (odds ratio [OR] = 1.45, 95% confidence interval [CI]: 1.23, 1.70), and limitations in activities of daily living (OR = 1.12, 95% CI: 1.03, 1.21). Denied applicants' physical functioning (40.3) and mental functioning (41.2) composite summary scores were not clinically different from those of awarded applicants (39.0 and 40.1, respectively), indicating that both were comparably impaired. Veterans denied VA disability compensation had poor health and functional impairments. They also experienced poverty and isolation, suggesting that they may be in need of additional supportive services. Connecting veterans to community resources could be a vital service to provide to all veterans applying for disability compensation. © 2016 National Association of Social Workers.

  3. Brain Basics

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    Full Text Available ... highly developed area at the front of the brain that, in humans, plays a role in executive functions such as ... component of the U.S. Department of Health and Human Services. Contact Us Staff Directories Privacy Notice Policies FOIA Accessibility Topic Finder Publicaciones en Español Top

  4. Brain Basics

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    Full Text Available ... at the front of the brain that, in humans, plays a role in executive functions such as ... ClinicalTrials.gov : Federally and privately supported research using human volunteers PubMed Central: An archive of life sciences ...

  5. The North/South Debate: Technology, Basic Human Needs and the New International Economic Order. Working Paper Number Twelve. 1980.

    Science.gov (United States)

    Galtung, Johan

    This document contains two articles by Johan Galtung presented as papers at an international conference on the relationship of technology to the environment and human needs. The monograph is part of a series intended to stimulate research, education, dialogue, and political action toward a just world order. The first paper, "Towards a New…

  6. The North/South Debate: Technology, Basic Human Needs and the New International Economic Order. Working Paper Number Twelve. 1980.

    Science.gov (United States)

    Galtung, Johan

    This document contains two articles by Johan Galtung presented as papers at an international conference on the relationship of technology to the environment and human needs. The monograph is part of a series intended to stimulate research, education, dialogue, and political action toward a just world order. The first paper, "Towards a New…

  7. Structural location determines functional roles of the basic amino acids of KR-12, the smallest antimicrobial peptide from human cathelicidin LL-37.

    Science.gov (United States)

    Mishra, Biswajit; Epand, Raquel F; Epand, Richard M; Wang, Guangshun

    2013-11-14

    Cationic antimicrobial peptides are recognized templates for developing a new generation of antimicrobials to combat superbugs. Human cathelicidin LL-37 is an essential host defense molecule in human innate immunity. Previously, we identified KR-12 as the smallest antibacterial peptide of LL-37. KR-12 has a narrow activity spectrum since it is active against Gram-negative Escherichia coli but not Gram-positive Staphylococcus aureus. The functional roles of the basic amino acids of KR-12, however, have not yet been elucidated. An alanine scan of cationic amino acids of KR-12 provided evidence for their distinct roles in the activities of the peptides. Bacterial killing and membrane permeation experiments indicate that the R23A and K25A mutants, as well as the lysine-to-arginine mutant, were more potent than KR-12. Another three cationic residues (K18, R19, and R29) of KR-12, which are located in the hydrophilic face of the amphiphathic helix, appeared to be more important in clustering anionic lipids or hemolysis than R23 and K25 in the interfacial region. While the loss of interfacial R23 or K25 reduced peptide helicity, underscoring its important role in membrane binding, the overall increase in peptide activity of KR-12 could be ascribed to the increased peptide hydrophobicity that outweighed the role of basic charge in this case. In contrast, the mutations of interfacial R23 or K25 reduced peptide bactericidal activity of GF-17, an overlapping, more hydrophobic and potent peptide also derived from LL-37. Thus, the hydrophobic context of the peptide determines whether an alanine substitution of an interfacial basic residue increases or decreases membrane permeation and peptide activity.

  8. Regression Basics

    CERN Document Server

    Kahane, Leo H

    2007-01-01

    Using a friendly, nontechnical approach, the Second Edition of Regression Basics introduces readers to the fundamentals of regression. Accessible to anyone with an introductory statistics background, this book builds from a simple two-variable model to a model of greater complexity. Author Leo H. Kahane weaves four engaging examples throughout the text to illustrate not only the techniques of regression but also how this empirical tool can be applied in creative ways to consider a broad array of topics. New to the Second Edition Offers greater coverage of simple panel-data estimation:

  9. Basic electronics

    CERN Document Server

    Tayal, DC

    2010-01-01

    The second edition of this book incorporates the comments and suggestions of my friends and students who have critically studied the first edition. In this edition the changes and additions have been made and subject matter has been rearranged at some places. The purpose of this text is to provide a comprehensive and up-to-date study of the principles of operation of solid state devices, their basic circuits and application of these circuits to various electronic systems, so that it can serve as a standard text not only for universities and colleges but also for technical institutes. This book

  10. Pine processionary caterpillar, Thaumetopoea pityocampa Denis and Schiffermüller, 1775 contact as a health risk for dogs.

    Science.gov (United States)

    Kaszak, Ilona; Planellas, Marta; Dworecka-Kaszak, Bożena

    2015-01-01

    Pine processionary, Thaumetopoea pityocampa Denis and Schiffermüller, 1775 is a moth that belongs to the order of insects Lepidoptera, and family Notodontidae. The larvae of pine processionary moth are the main pest of pines all over the world, but mainly in Mediterranean region. The contact with pine processionary caterpillar (lepidopterism) can produce a strong inflammatory reaction on skin and mucous membranes. Other findings include hyperthermia, tachypnoea, respiratory distress, cyanosis and tongue oedema, labial angioedema, ptyalism, bilateral submandibular lymphadenomegaly, conjunctivitis and severe tongue necrosis. Tough, few veterinary cases have been published. Also in Poland pine processionary moth (Thaumetopoea pinivora) is present, especially near the Baltic coast and can be a possible health risk for both humans and animals (especially dogs). The aim of this article is to increase knowledge about the clinical manifestations of pine processionary caterpillar contact, which may be useful for diagnosis of this dangerous disease.

  11. Integrated navigation of aerial robot for GPS and GPS-denied environment

    Science.gov (United States)

    Suzuki, Satoshi; Min, Hongkyu; Wada, Tetsuya; Nonami, Kenzo

    2016-09-01

    In this study, novel robust navigation system for aerial robot in GPS and GPS- denied environments is proposed. Generally, the aerial robot uses position and velocity information from Global Positioning System (GPS) for guidance and control. However, GPS could not be used in several environments, for example, GPS has huge error near buildings and trees, indoor, and so on. In such GPS-denied environment, Laser Detection and Ranging (LIDER) sensor based navigation system have generally been used. However, LIDER sensor also has an weakness, and it could not be used in the open outdoor environment where GPS could be used. Therefore, it is desired to develop the integrated navigation system which is seamlessly applied to GPS and GPS-denied environments. In this paper, the integrated navigation system for aerial robot using GPS and LIDER is developed. The navigation system is designed based on Extended Kalman Filter, and the effectiveness of the developed system is verified by numerical simulation and experiment.

  12. Study of human factors and its basic aspects, focusing the operators of IEA-R1 research reactor

    Energy Technology Data Exchange (ETDEWEB)

    Martins, Maria da Penha Sanches; Andrade, Delvonei Alves de [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)]. E-mails: penhamartins@yahoo.com.br; delvonei@ipen.br

    2007-07-01

    The objective of this work is the study of human factors and situational variables, which, when modified, can interfere in the work actions of the operators of nuclear installations. This work is focused on the operators of the IEA-R1 research reactor, which is located in the Instituto de Pesquisas Energeticas e Nucleares - IPEN - CNEN/SP. The accidents in Nuclear Plants have shown that the most serious have occurred due to human failure. This work also considers the item 5.5.3 of CNEN-NN-3.01 standard - 'Actions must be taken to reduce, as much as possible, the human failures that may lead to accidents or even other events which may originate inadvertent or unintentional expositions in any individual'. The model named - Behavioral Analysis - is adopted. Relevant factors and aspects of the operators' routine are also considered. It is worth to remind that the performance depends on a series of variables, not only on the individual, but also the situational ones, which include physical, work, environment, organizational and social variables. Subjective factors are also considered, such as: attitude, ability, motivation etc., aiming at a global perspective of the situation, which counts on a set of principles for the behavior analysis and comprehension. After defining the applicability scenario, mechanisms and corrective actions to contribute with the reduction of failures will be proposed. (author)

  13. Study of human factors and its basic aspects, focusing the operators of IEA-R1 research reactor

    Energy Technology Data Exchange (ETDEWEB)

    Martins, Maria da Penha Sanches; Andrade, Delvonei Alves de [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)]. E-mails: penhamartins@yahoo.com.br; delvonei@ipen.br

    2008-03-15

    Human factors and situational variables, which ca, when modified, interfere in the actions of operators of nuclear installations is studied. This work is focused in the operators of the IEA-R1 research reactor, which is located in the Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Brazil. The accidents in Nuclear Plants have shown that the most serious have occurred due to human failure. This work also considers the item 5.5.3 of CNEN-NN-3.01 standard - 'Actions must be taken to reduce, as much as possible, the human failures that can lead to accidents or even other events which can originate inadvertent or unintentional expositions in any individual'. The model named 'Behavioral Analysis' is adopted. Relevant factors and aspects of the operators' routine are also considered. It is worth to remind that the performance depends on a series of variables, not only on the individual, but also situational, including in these categories; physical variables, work environment, organizational and the social ones. The subjective factors are also considered, such as: attitude, ability, motivation etc., aiming at a global perspective of the situation, which counts on a set of principles for the behaviour analysis and comprehension. After defining the applicability scenario, mechanisms and corrective actions to contribute with the reduction of failures will be proposed. (author)

  14. [Retinotopic mapping of the human visual cortex with functional magnetic resonance imaging - basic principles, current developments and ophthalmological perspectives].

    Science.gov (United States)

    Hoffmann, M B; Kaule, F; Grzeschik, R; Behrens-Baumann, W; Wolynski, B

    2011-07-01

    Since its initial introduction in the mid-1990 s, retinotopic mapping of the human visual cortex, based on functional magnetic resonance imaging (fMRI), has contributed greatly to our understanding of the human visual system. Multiple cortical visual field representations have been demonstrated and thus numerous visual areas identified. The organisation of specific areas has been detailed and the impact of pathophysiologies of the visual system on the cortical organisation uncovered. These results are based on investigations at a magnetic field strength of 3 Tesla or less. In a field-strength comparison between 3 and 7 Tesla, it was demonstrated that retinotopic mapping benefits from a magnetic field strength of 7 Tesla. Specifically, the visual areas can be mapped with high spatial resolution for a detailed analysis of the visual field maps. Applications of fMRI-based retinotopic mapping in ophthalmological research hold promise to further our understanding of plasticity in the human visual cortex. This is highlighted by pioneering studies in patients with macular dysfunction or misrouted optic nerves.

  15. Brain Basics

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    Full Text Available ... are sent from one neuron to another. Share Science News Post-ER Suicide Prevention Strategies are Cost ... human volunteers PubMed Central: An archive of life sciences journals NIH Research Fact Sheets NIH Office of ...

  16. Brain Basics

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    Full Text Available ... National Library of Medicine Contact Us Staff Directories Privacy Notice Policies FOIA Accessibility Topic Finder Publicaciones en ... Health and Human Services. Contact Us Staff Directories Privacy Notice Policies FOIA Accessibility Topic Finder Publicaciones en ...

  17. Brain Basics

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    Full Text Available ... are sent from one neuron to another. Share Science News Higher Death Rate Among Youth with Psychosis ... human volunteers PubMed Central: An archive of life sciences journals NIH Research Fact Sheets NIH Office of ...

  18. Brain Basics

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    Full Text Available ... human volunteers PubMed Central: An archive of life sciences journals NIH Research Fact Sheets NIH Office of Science Education : Resources for science educators Pillbox: How to ...

  19. Brain Basics

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    Full Text Available ... highly developed area at the front of the brain that, in humans, plays a role in executive functions such as ... Higher Death Rate Among Youth with Psychosis Delayed Walking Link ...

  20. Egalitarianism, basic structure and rawlsian contextualism

    Directory of Open Access Journals (Sweden)

    Cristián Fatauros

    2015-09-01

    Full Text Available This paper analyses whether it is appropriate to judge individual actions with the same principles of justice applicable to institutions. In order to achieve its aim the paper reviews Rawls` theory of justice and some objections against it. Critics of Rawlsian theory of justice deny that its principles only evaluate basic institutions. Furthermore, they claim that justice does not only require just institutions but just individual actions as well. The background hypothesis of this paper is that some principles suitable for some social contexts are not useful to judge other kind of social interactions. The argument relies on a normative interpretation of the notion of basic structure, which is considered a key element to defend the institutional character of the rawlsian account of justice.

  1. Effects of Nerve Growth Factor and Basic Fibroblast Growth Factor Promote Human Dental Pulp Stem Cells to Neural Differentiation.

    Science.gov (United States)

    Zhang, Jinlong; Lian, Min; Cao, Peipei; Bao, Guofeng; Xu, Guanhua; Sun, Yuyu; Wang, Lingling; Chen, Jiajia; Wang, Yi; Feng, Guijuan; Cui, Zhiming

    2017-04-01

    Dental pulp stem cells (DPSCs) were the most widely used seed cells in the field of neural regeneration and bone tissue engineering, due to their easily isolation, lack of ethical controversy, low immunogenicity and low rates of transplantation rejection. The purpose of this study was to investigate the role of basic fibroblast growth factor (bFGF) and nerve growth factor (NGF) on neural differentiation of DPSCs in vitro. DPSCs were cultured in neural differentiation medium containing NGF and bFGF alone or combination for 7 days. Then neural genes and protein markers were analyzed using western blot and RT-PCR. Our study revealed that bFGF and NGF increased neural differentiation of DPSCs synergistically, compared with bFGF and NGF alone. The levels of Nestin, MAP-2, βIII-tubulin and GFAP were the most highest in the DPSCs + bFGF + NGF group. Our results suggested that bFGF and NGF signifiantly up-regulated the levels of Sirt1. After treatment with Sirt1 inhibitor, western blot, RT-PCR and immunofluorescence staining showed that neural genes and protein markers had markedly decreased. Additionally, the ERK and AKT signaling pathway played a key role in the neural differentiation of DPSCs stimulated with bFGF + NGF. These results suggested that manipulation of the ERK and AKT signaling pathway may be associated with the differentiation of bFGF and NGF treated DPSCs. Our date provided theoretical basis for DPSCs to treat neurological diseases and repair neuronal damage.

  2. The pedunculopontine tegmental nucleus: from basic neuroscience to neurosurgical applications: arousal from slices to humans: implications for DBS.

    Science.gov (United States)

    Garcia-Rill, Edgar; Simon, Christen; Smith, Kristen; Kezunovic, Nebosja; Hyde, James

    2011-10-01

    One element of the reticular activating system (RAS) is the pedunculopontine nucleus (PPN), which projects to the thalamus to trigger thalamocortical rhythms and the brainstem to modulate muscle tone and locomotion. The PPN is a posterior midbrain site known to induce locomotion in decerebrate animals when activated at 40-60 Hz, and has become a target for DBS in disorders involving gait deficits. We developed a research program using brainstem slices containing the PPN to study the cellular and molecular organization of this region. We showed that PPN neurons preferentially fire at gamma band frequency (30-60 Hz) when maximally activated, accounting for the effects of electrical stimulation. In addition, we developed the P13 midlatency auditory evoked potential, which is generated by PPN outputs, in freely moving rats. This allows the study of PPN cellular and molecular mechanisms in the whole animal. We also study the P50 midlatency auditory evoked potential, which is the human equivalent of the rodent P13 potential, allowing us to study PPN-related processes detected in vitro, confirmed in the whole animal, and tested in humans. Previous findings on the P50 potential in PD suggest that PPN output in this disorder is overactive. This translational research program led to the discovery of a novel mechanism of sleep-wake control based on electrical coupling, pointing the way to a number of new clinical applications in the development of novel stimulants (e.g., modafinil) and anesthetics. In addition, it provides methods for monitoring therapeutic efficacy of DBS in humans and animal models.

  3. Drug Distribution to Human Tissues: Prediction and Examination of the Basic Assumption in In Vivo Pharmacokinetics-Pharmacodynamics (PK/PD) Research.

    Science.gov (United States)

    Poulin, Patrick

    2015-06-01

    The tissue:plasma partition coefficients (Kp ) are good indicators of the extent of tissue distribution. Therefore, advanced tissue composition-based models were used to predict the Kp values of drugs under in vivo conditions on the basis of in vitro and physiological input data. These models, however, focus on animal tissues and do not challenge the predictions with human tissues for drugs. The first objective of this study was to predict the experimentally determined Kp values of seven human tissues for 26 drugs. In all, 95% of the predicted Kp values are within 2.5-fold error of the observed values in humans. Accordingly, these results suggest that the tissue composition-based model used in this study is able to provide accurate estimates of drug partitioning in the studied human tissues. Furthermore, as the Kp equals to the ratio of total concentration between tissue and plasma, or the ratio of unbound fraction between plasma (fup ) and tissue (fut ), this parameter Kp would deviate from the unity. Therefore, the second objective was to examine the corresponding relationships between fup and fut values experimentally determined in humans for several drugs. The results also indicate that fup may significantly deviate to fut ; the discrepancies are governed by the dissimilarities in the binding and ionization on both sides of the membrane, which were captured by the tissue composition-based model. Hence, this violated the basic assumption in in vivo pharmacokinetics-pharmacodynamics (PK/PD) research, since the free drug concentration in tissue and plasma was not equal particularly for the ionizable drugs due to the pH gradient effect on the fraction of unionized drug in plasma (fuip ) and tissue (fuit ) (i.e., fup × fuip × total plasma concentration = fut × fuit × total tissue concentration, and, hence, the free drug concentration in plasma and tissue differed by fuip/fuit). Therefore, this assumption should be adjusted for the ionized drugs, and, hence, a

  4. Basic investigation on acoustic velocity change imaging method for quantitative assessment of fat content in human liver

    Science.gov (United States)

    Mano, Kazune; Tanigawa, Shohei; Hori, Makoto; Yokota, Daiki; Wada, Kenji; Matsunaka, Toshiyuki; Morikawa, Hiroyasu; Horinaka, Hiromichi

    2016-07-01

    Fatty liver is a disease caused by the excess accumulation of fat in the human liver. The early diagnosis of fatty liver is very important, because fatty liver is the major marker linked to metabolic syndrome. We already proposed the ultrasonic velocity change imaging method to diagnose fatty liver by using the fact that the temperature dependence of ultrasonic velocity is different in water and in fat. For the diagonosis of a fatty liver stage, we attempted a feasibility study of the quantitative assessment of the fat content in the human liver using our ultrasonic velocity change imaging method. Experimental results showed that the fat content in the tissue mimic phantom containing lard was determined by its ultrasonic velocity change in the flat temperature region formed by a circular warming ultrasonic transducer with an acoustic lens having an appropriate focal length. By considering the results of our simulation using a thermal diffusion equation, we determined whether this method could be applied to fatty liver assessment under the condition that the tissue had the thermal relaxation effect caused by blood flow.

  5. Crystal structure of human protein kinase CK2: insights into basic properties of the CK2 holoenzyme

    DEFF Research Database (Denmark)

    Niefind, K; Guerra, B; Ermakowa, I;

    2001-01-01

    subunits, which make no direct contact with one another. Each catalytic subunit interacts with both regulatory chains, predominantly via an extended C-terminal tail of the regulatory subunit. The CK2 structure is consistent with its constitutive activity and with a flexible role of the regulatory subunit......The crystal structure of a fully active form of human protein kinase CK2 (casein kinase 2) consisting of two C-terminally truncated catalytic and two regulatory subunits has been determined at 3.1 A resolution. In the CK2 complex the regulatory subunits form a stable dimer linking the two catalytic...... as a docking partner for various protein kinases. Furthermore it shows an inter-domain mobility in the catalytic subunit known to be functionally important in protein kinases and detected here for the first time directly within one crystal structure....

  6. Effects of recombinant human basic fibroblast growth factor on cell proliferation during mandibular fracture healing in rabbits

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Objective: To investigate the effects of recombinant human basicfibroblast growth factor (rhbFGF) on the cell proliferation during mandibular fracture healing in rabbits.Methods: The complex of rhbFGF and bovine type I collagen was implanted into the mandibular fracture site under periosteum of the animal. The whole mandible was harvested at 7, 14, 28, 56 and 84 days respectively after operation. The expression of proliferating cell nuclear antigen (PCNA) in callus was examined with immunohistochemical staining.Results: PCNA-positive cells in callus in the rhbFGF-treated group on days 7 and 14 were more than that in the control group (P<0.01).Conclusions: It indicates that rhbFGF can stimulate cell proliferation during mandibular fracture healing in rabbits.

  7. Etnografia e manejo de recursos naturais pelos índios Deni, Amazonas, Brasil Ethnography and natural resources management by the Deni Indians, Amazonas, Brazil

    Directory of Open Access Journals (Sweden)

    Juarez Pezzuti

    2009-03-01

    Full Text Available São raros os estudos envolvendo o uso múltiplo de recursos naturais por populações amazônicas. Este trabalho apresenta um panorama de como os índios Deni, habitantes da região de interflúvio entre dois dos maiores afluentes de água branca da bacia amazônica, os rios Juruá e Purus, utilizam dos recursos disponíveis em seu território. Os Deni são, atualmente, índios que vivem da exploração de recursos da terra firme e de regiões alagadas. São um misto de horticultores e caçadores/coletores, que utilizam toda a sua área para a obtenção de recursos para subsistência. Como regra, deslocam periodicamente seus assentamentos, evitando o esgotamento local de recursos, e provocando a modificação local do ambiente. Esta alteração aumenta temporariamente a disponibilidade de alimento. Áreas com aldeias, pomares e roçados abandonados, por sua vez, tornam-se locais onde se concentram inúmeros recursos da flora e da fauna, posteriormente explorados. O impacto provocado por este sistema é aparentemente mínimo. Os Deni estão contextualizados na periferia de um sistema capitalista, onde a única fonte de renda para adquirir bens que são hoje considerados pelos índios como indispensáveis para sua sobrevivência são os recursos naturais. Estes são e continuarão sendo explorados de maneira a produzir um excedente a ser comercializado para a obtenção de uma série de produtos industrializados, independentemente das opiniões externas. É sobre este patamar que devemos avaliar a sustentabilidade do atual manejo da área.Studies concerning the use of multiple natural resources by Amazonian indians are scarce. This work presents a portrait of how the Deni Indians, inhabitants of an area between two of the most important white-water rivers of the Amazon basin (Juruá and Purus Rivers, exploit natural resources in their territory. The Deni exploit both the upland and floodplain forests. They are a mix of horticulturalists and

  8. Brain Basics

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  9. Brain Basics

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  10. Brain Basics

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  11. Brain Basics

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    Full Text Available ... Priorities Research Priorities Home Research Areas Policies and Procedures Research Resources Research Domain Criteria (RDoC) Funding Funding Home ... Month May 2017 PTSD Awareness Month June 2017 General ... and privately supported research using human volunteers PubMed Central: An archive of ...

  12. Brain Basics

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    Full Text Available ... PTSD) . Prefrontal cortex (PFC) —Seat of the brain's executive functions, such as judgment, decision making, and problem solving. ... brain that, in humans, plays a role in executive functions such as judgment, decision making and problem solving, ...

  13. Brain Basics

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    Full Text Available ... rise to disabilities or diseases. neural circuit —A network of neurons and their interconnections. neuron —A nerve ... of the U.S. Department of Health and Human Services. Contact Us Staff Directories Privacy Notice Policies FOIA ...

  14. Brain Basics

    Medline Plus

    Full Text Available ... are sent from one neuron to another. Share Science News Male/Female Depression Differs Molecularly RDoC Webinar - ... human volunteers PubMed Central: An archive of life sciences journals NIH Research Fact Sheets NIH Office of ...

  15. Brain Basics

    Medline Plus

    Full Text Available ... ClinicalTrials.gov : Federally and privately supported research using human volunteers PubMed Central: An archive of life sciences journals NIH Research Fact Sheets NIH Office of Science Education : Resources for science educators Pillbox: How to identify unknown ...

  16. Brain Basics

    Medline Plus

    Full Text Available ... cell that contains DNA and information the cell needs for growing, staying alive, and making new neurons. prefrontal cortex —A highly developed area at the front of the brain that, in humans, plays a role in executive functions such as ...

  17. Inflation Basics

    Energy Technology Data Exchange (ETDEWEB)

    Green, Dan [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States)

    2014-03-01

    inflation since metrical fluctuations, both scalar and tensor, are also produced in inflationary models. Thus, the time appears to be appropriate for a very basic and simple exposition of the inflationary model written from a particle physics perspective. Only the simplest scalar model will be explored because it is easy to understand and contains all the basic elements of the inflationary model.

  18. Inflation Basics

    Energy Technology Data Exchange (ETDEWEB)

    Green, Dan [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States)

    2014-03-01

    inflation since metrical fluctuations, both scalar and tensor, are also produced in inflationary models. Thus, the time appears to be appropriate for a very basic and simple exposition of the inflationary model written from a particle physics perspective. Only the simplest scalar model will be explored because it is easy to understand and contains all the basic elements of the inflationary model.

  19. Survival Right and Development Right is Basic Human Rights%简论生存权和发展权是首要的基本人权

    Institute of Scientific and Technical Information of China (English)

    陆德生

    2013-01-01

      Our party and our country have repeatedly stressed survival rights and development rights are basic human rights. In advancing the cause of human rights of Chinese characteristic socialism,our survival rights and development rights are well protected and implemented. The report of 18th CPC National Congress emphasizes that we should better realize scientific development,strengthen democracy and law,concern more about people's livelihood,uphold fairness and justice and make human rights respected and protected in the reality. In the future,our survival rights and development rights will be far better developed.%  党和国家一再强调生存权和发展权是首要的基本人权。在全面推进中国特色社会主义人权事业中,我国人民的生存权和发展权得到了很好的保障和落实。党的十八大报告强调要更好地实现科学发展,加强民主法治,高度关注民生,坚持公平正义,人权得到切实尊重和保障。展望未来,我国人民的生存权和发展权必将得到更大更好地发展。

  20. Establishment of LIF-dependent human iPS cells closely related to basic FGF-dependent authentic iPS cells.

    Directory of Open Access Journals (Sweden)

    Hiroyuki Hirai

    Full Text Available Human induced pluripotent stem cells (iPSCs can be divided into a leukemia inhibitory factor (LIF-dependent naïve type and a basic fibroblast growth factor (bFGF-dependent primed type. Although the former are more undifferentiated than the latter, they require signal transduction inhibitors and sustained expression of the transgenes used for iPSC production. We used a transcriptionally enhanced version of OCT4 to establish LIF-dependent human iPSCs without the use of inhibitors and sustained transgene expression. These cells belong to the primed type of pluripotent stem cell, similar to bFGF-dependent iPSCs. Thus, the particular cytokine required for iPSC production does not necessarily define stem cell phenotypes as previously thought. It is likely that the bFGF and LIF signaling pathways converge on unidentified OCT4 target genes. These findings suggest that our LIF-dependent human iPSCs could provide a novel model to investigate the role of cytokine signaling in cellular reprogramming.

  1. ``What if we were in a test tube?'' Students' gendered meaning making during a biology lesson about the basic facts of the human genitals

    Science.gov (United States)

    Orlander, Auli Arvola

    2014-06-01

    This paper explores what happens in the encounters between presentations of "basic facts" about the human genitals and 15-year-old students during a biology lesson in a Swedish secondary school. In this paper, meaning making was approached as relational, context-dependent and continually transacted. For this reason the analysis was conducted through a series of close readings of situations where students interacted with each other and the teacher in opening up gaps about alternative ways of discussing gender. Drawing on Foucault's theories about the inclusion and exclusion of knowledge and the subsequent work of Butler and other feminist researchers, the paper illuminates what gendered relations remain tacit in the conversation. It then illustrates possible ways in which these tacit gendered meanings could be made overt and discussed with the students when making meaning about the human genitals. The paper also shows how the ways in which human genitals are transacted in the science classroom have importance for what kind of learning is made available to the students.

  2. 40 CFR 270.130 - What is the process for approving or denying my application for a RAP?

    Science.gov (United States)

    2010-07-01

    ... denying my application for a RAP? 270.130 Section 270.130 Protection of Environment ENVIRONMENTAL... PERMIT PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.130 What is the process for approving or denying my application for a RAP? (a) If the Director tentatively finds that your RAP...

  3. ERT basics

    Energy Technology Data Exchange (ETDEWEB)

    Butters, M. [MBC Energy and Environment, Ottawa, ON (Canada)]|[National Round Table on the Environment and the Economy, Ottawa, ON (Canada)

    2002-07-01

    ERT is an economic instrument which helps power companies achieve emission reduction compliance cost-effectively. This paper presents the basics of ERT with reference to trading concepts, types of systems and types of emissions. The paper also describes the state of the Canadian energy market regarding greenhouse gases (GHG), nitrogen oxides, sulphur dioxide and volatile organic compounds. The association between ERT and district energy is also explained. By 2010, the global market for GHG trading is expected to be worth $10 billion to $3 trillion U.S. Canada has committed to reducing its GHG to 6 per cent below 1990 levels by 2012, but currently emits 705 Mt per year. This is expected to increase to 770 Mt by 2010. Therefore, in order to meet its commitment, GHGs will have to be reduced 200 Mt per year. Canada is currently considering ratifying the Kyoto agreement and a trading system is being developed. There are several abatement technologies currently under consideration for district energy systems, including adding scrubbers, improving efficiency, and fuel switching. The marginal cost of abatement was also discussed. tabs., figs.

  4. Redirecting Therapeutic T Cells against Myelin-Specific T Lymphocytes Using a Humanized Myelin Basic Protein-HLA-DR2-{zeta} Chimeric Receptor

    DEFF Research Database (Denmark)

    Moisini, Ioana; Nguyen, Phuong; Fugger, Lars

    2008-01-01

    Therapies that Ag-specifically target pathologic T lymphocytes responsible for multiple sclerosis (MS) and other autoimmune diseases would be expected to have improved therapeutic indices compared with Ag-nonspecific therapies. We have developed a cellular immunotherapy that uses chimeric receptors...... to selectively redirect therapeutic T cells against myelin basic protein (MBP)-specific T lymphocytes implicated in MS. We generated two heterodimeric receptors that genetically link the human MBP(84-102) epitope to HLA-DR2 and either incorporate or lack a TCRzeta signaling domain. The Ag-MHC domain serves...... as a bait, binding the TCR of MBP-specific target cells. The zeta signaling region stimulates the therapeutic cell after cognate T cell engagement. Both receptors were well expressed on primary T cells or T hybridomas using a tricistronic (alpha, beta, green fluorescent protein) retroviral expression system...

  5. Indoor radar SLAM A radar application for vision and GPS denied environments

    NARCIS (Netherlands)

    Marck, J.W.; Mohamoud, A.A.; Houwen, E.H. van de; Heijster, R.M.E.M. van

    2013-01-01

    Indoor navigation especially in unknown areas is a real challenge. Simultaneous Localization and Mapping (SLAM) technology provides a solution. However SLAM as currently based on optical sensors, is unsuitable in vision denied areas, which are for example encountered by first responders. Radar can

  6. 75 FR 56504 - Action Affecting Export Privileges; Rigel Optics, Inc. and Donald Wayne Hatch; Order Denying...

    Science.gov (United States)

    2010-09-16

    ... August 12, 2010 (75 FR 50681, August 16, 2010), has continued the Regulations in effect under the... Bureau of Industry and Security Action Affecting Export Privileges; Rigel Optics, Inc. and Donald Wayne Hatch; Order Denying Export Privileges In the Matter of: Rigel Optics, Inc., 477 South 28th...

  7. Aspects of the Asian American Experience – Rights Denied and Attained

    Directory of Open Access Journals (Sweden)

    Roger Daniels

    2008-06-01

    Full Text Available This essay describes and analyzes the various statutory and constitutional provisions which denied specific rights to Asian immigrants and their descendants and relates the various processes by which these rights were granted or restored from the earliest days of the American republic to the penultimate decade of the 20th century.

  8. 47 CFR 73.3588 - Dismissal of petitions to deny or withdrawal of informal objections.

    Science.gov (United States)

    2010-10-01

    ... withdraw the petition to deny or the informal objection, either unilaterally or in exchange for financial consideration, that party must file with the Commission a request for approval of the dismissal or withdrawal, a... money or other consideration in excess of legitimate and prudent expenses in exchange for the dismissal...

  9. 75 FR 41921 - Agency Information Collection; Activity Under OMB Review; Report of Passengers Denied Confirmed...

    Science.gov (United States)

    2010-07-19

    ... information is available in the Air Travel Consumer Report at: http://airconsumer.ost.dot.gov/reports/index.htm . The Air Travel Consumer Report is also sent to newspapers, magazines, and trade journals...; Report of Passengers Denied Confirmed Space AGENCY: Research & Innovative Technology Administration...

  10. 77 FR 18305 - Agency Information Collection; Activity Under OMB Review; Report of Passengers Denied Confirmed...

    Science.gov (United States)

    2012-03-27

    ... information is available in the Air Travel Consumer Report at: http://airconsumer.ost.dot.gov/reports/index.htm . The Air Travel Consumer Report is also sent to newspapers, magazines, and trade journals. The...; Report of Passengers Denied Confirmed Space--BTS Form 251 AGENCY: Research & Innovative...

  11. Indoor radar SLAM A radar application for vision and GPS denied environments

    NARCIS (Netherlands)

    Marck, J.W.; Mohamoud, A.A.; Houwen, E.H. van de; Heijster, R.M.E.M. van

    2013-01-01

    Indoor navigation especially in unknown areas is a real challenge. Simultaneous Localization and Mapping (SLAM) technology provides a solution. However SLAM as currently based on optical sensors, is unsuitable in vision denied areas, which are for example encountered by first responders. Radar can b

  12. 48 CFR 19.602-2 - Issuing or denying a Certificate of Competency (COC).

    Science.gov (United States)

    2010-10-01

    ... Certificate of Competency (COC). 19.602-2 Section 19.602-2 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Certificates of Competency and Determinations of Responsibility 19.602-2 Issuing or denying a Certificate of Competency (COC). Within...

  13. 78 FR 11142 - Connor Hayden Kraegel, 19917 Spurrier Avenue, Poolesville, MD 20837; Order Denying Export Privileges

    Science.gov (United States)

    2013-02-15

    ...; Order Denying Export Privileges On August 24, 2011, in the U.S. District Court, District of Maryland, Connor Hayden Kraegel (``Kraegel'') was convicted of violating Section 38 of the Arms Export Control Act... and willfully exporting from the United States a set of AN/AVS-6 night vision goggles, which...

  14. Differences of Personality, Defensiveness, and Compliance between Admitting and Denying Male Sex Offenders.

    Science.gov (United States)

    Birgisson, Gunnar Hrafn

    1996-01-01

    Assessed predicted psychological differences between denying (n=30) and admitting (n=72) male sex offenders within the framework of Eysenck's theory on the personality of criminals. The Eysenck Personality Questionnaire (EPQ) and Gudjonsson's Compliance Questionnaire (CQ) were administered to consenting participants who were probationers in…

  15. Functional diversity of human basic helix-loop-helix transcription factor TCF4 isoforms generated by alternative 5' exon usage and splicing.

    Directory of Open Access Journals (Sweden)

    Mari Sepp

    Full Text Available BACKGROUND: Transcription factor 4 (TCF4 alias ITF2, E2-2, ME2 or SEF2 is a ubiquitous class A basic helix-loop-helix protein that binds to E-box DNA sequences (CANNTG. While involved in the development and functioning of many different cell types, recent studies point to important roles for TCF4 in the nervous system. Specifically, human TCF4 gene is implicated in susceptibility to schizophrenia and TCF4 haploinsufficiency is the cause of the Pitt-Hopkins mental retardation syndrome. However, the structure, expression and coding potential of the human TCF4 gene have not been described in detail. PRINCIPAL FINDINGS: In the present study we used human tissue samples to characterize human TCF4 gene structure and TCF4 expression at mRNA and protein level. We report that although widely expressed, human TCF4 mRNA expression is particularly high in the brain. We demonstrate that usage of numerous 5' exons of the human TCF4 gene potentially yields in TCF4 protein isoforms with 18 different N-termini. In addition, the diversity of isoforms is increased by alternative splicing of several internal exons. For functional characterization of TCF4 isoforms, we overexpressed individual isoforms in cultured human cells. Our analysis revealed that subcellular distribution of TCF4 isoforms is differentially regulated: Some isoforms contain a bipartite nuclear localization signal and are exclusively nuclear, whereas distribution of other isoforms relies on heterodimerization partners. Furthermore, the ability of different TCF4 isoforms to regulate E-box controlled reporter gene transcription is varied depending on whether one or both of the two TCF4 transcription activation domains are present in the protein. Both TCF4 activation domains are able to activate transcription independently, but act synergistically in combination. CONCLUSIONS: Altogether, in this study we have described the inter-tissue variability of TCF4 expression in human and provided evidence

  16. Who is the “God” Nietzsche denied?

    Directory of Open Access Journals (Sweden)

    André J. Groenwald

    2005-10-01

    Full Text Available This article examines the reasons that brought Nietzsche to the point of declaring that God is dead, thus doubting the existence of God. Nietzsche’s was a reaction to modernity’s belief in progress as perceived through the philosophy of Hegel, while also being a reaction to the knowing subject of Descartes and Kant and the theology of Strauss. Nietzsche’s quest was for a concept of God that would be free from human domination.

  17. Basic Fibroblast Growth Factor-Mediated Overexpression of Vascular Endothelial Growth Factor in 1F6 Human Melanoma Cells is Regulated by Activation of PI-3K and p38 MAPK

    Directory of Open Access Journals (Sweden)

    Dennis Fontijn

    2009-01-01

    Full Text Available Background: 1F6 human melanoma xenografts overexpressing either the 18 kD (18kD form or all (ALL forms of human basic fibroblast growth factor (bFGF demonstrate an abundant number of microvessels and accelerated growth. We now examined whether bFGF mediates vascular endothelial growth factor (VEGF expression.

  18. Novel sequential ChIP and simplified basic ChIP protocols for promoter co-occupancy and target gene identification in human embryonic stem cells

    Directory of Open Access Journals (Sweden)

    Elayaperumal Anuratha

    2009-06-01

    Full Text Available Abstract Background The investigation of molecular mechanisms underlying transcriptional regulation, particularly in embryonic stem cells, has received increasing attention and involves the systematic identification of target genes and the analysis of promoter co-occupancy. High-throughput approaches based on chromatin immunoprecipitation (ChIP have been widely used for this purpose. However, these approaches remain time-consuming, expensive, labor-intensive, involve multiple steps, and require complex statistical analysis. Advances in this field will greatly benefit from the development and use of simple, fast, sensitive and straightforward ChIP assay and analysis methodologies. Results We initially developed a simplified, basic ChIP protocol that combines simplicity, speed and sensitivity. ChIP analysis by real-time PCR was compared to analysis by densitometry with the ImageJ software. This protocol allowed the rapid identification of known target genes for SOX2, NANOG, OCT3/4, SOX17, KLF4, RUNX2, OLIG2, SMAD2/3, BMI-1, and c-MYC in a human embryonic stem cell line. We then developed a novel Sequential ChIP protocol to investigate in vivo promoter co-occupancy, which is basically characterized by the absence of antibody-antigen disruption during the assay. It combines centrifugation of agarose beads and magnetic separation. Using this Sequential ChIP protocol we found that c-MYC associates with the SOX2/NANOG/OCT3/4 complex and identified a novel RUNX2/BMI-1/SMAD2/3 complex in BG01V cells. These two TF complexes associate with two distinct sets of target genes. The RUNX2/BMI-1/SMAD2/3 complex is associated predominantly with genes not expressed in undifferentiated BG01V cells, consistent with the reported role of those TFs as transcriptional repressors. Conclusion These simplified basic ChIP and novel Sequential ChIP protocols were successfully tested with a variety of antibodies with human embryonic stem cells, generated a number of novel

  19. Recognizing victims of human trafficking in the pediatric emergency department.

    Science.gov (United States)

    Becker, Heather J; Bechtel, Kirsten

    2015-02-01

    Human trafficking is a form of modern-day slavery that is rapidly expanding in the United States and throughout the world. It is a crime under both the United States and international law. The child and adult victims of human trafficking are denied their basic human rights and subjected to unspeakable physical and emotional harm. Traffickers exert complete control over their victims and are proficient at hiding their condition from authorities. Healthcare practitioners may be the only professionals who come into contact with victims if they present for medical care. This article will describe human trafficking and its potential victims, as well as guide medical management and access to services that will ensure their safety and restore their freedom.

  20. The impact of a single administration of intranasal oxytocin on the recognition of basic emotions in humans: a meta-analysis.

    Science.gov (United States)

    Shahrestani, Sara; Kemp, Andrew H; Guastella, Adam J

    2013-09-01

    Many studies have highlighted the potential of oxytocin (OT) to enhance facial affect recognition in healthy humans. However, inconsistencies have emerged with regard to the influence of OT on the recognition of specific emotional expressions (happy, angry, fear, surprise, disgust, and sadness). In this study, we conducted a meta-analysis of seven studies comprising 381 research participants (71 females) examining responses to the basic emotion types to assess whether OT enhances the recognition of emotion from human faces and whether this was influenced by the emotion expression and exposure time of the face. Results showed that intranasal OT administration enhances emotion recognition of faces overall, with a Hedges g effect size of 0.29. When analysis was restricted to facial expression types, significant effects of OT on recognition accuracy were specifically found for the recognition of happy and fear faces. We also found that effect sizes increased to moderate when exposure time of the photograph was restricted to early phase recognition (recognition for fear faces (> 300 ms). The results of the meta-analysis further suggest that OT has potential as a treatment to improve the recognition of emotion in faces, allowing individuals to improve their insight into the intentions, desires, and mental states of others.

  1. Elevated endogenous expression of the dominant negative basic helix-loop-helix protein ID1 correlates with significant centrosome abnormalities in human tumor cells

    Directory of Open Access Journals (Sweden)

    Gutmann Anja

    2010-01-01

    Full Text Available Abstract Background ID proteins are dominant negative inhibitors of basic helix-loop-helix transcription factors that have multiple functions during development and cellular differentiation. Ectopic (over-expression of ID1 extends the lifespan of primary human epithelial cells. High expression levels of ID1 have been detected in multiple human malignancies, and in some have been correlated with unfavorable clinical prognosis. ID1 protein is localized at the centrosomes and forced (over-expression of ID1 results in errors during centrosome duplication. Results Here we analyzed the steady state expression levels of the four ID-proteins in 18 tumor cell lines and assessed the number of centrosome abnormalities. While expression of ID1, ID2, and ID3 was detected, we failed to detect protein expression of ID4. Expression of ID1 correlated with increased supernumerary centrosomes in most cell lines analyzed. Conclusions This is the first report that shows that not only ectopic expression in tissue culture but endogenous levels of ID1 modulate centrosome numbers. Thus, our findings support the hypothesis that ID1 interferes with centrosome homeostasis, most likely contributing to genomic instability and associated tumor aggressiveness.

  2. Effects of caffeine and triazolam on human basic +GZ tolerance%咖啡因和三唑仑对人体基础+GZ耐力的影响

    Institute of Scientific and Technical Information of China (English)

    耿喜臣; 詹皓; 颜桂定; 初旭; 张五星; 辛益妹

    2001-01-01

    Objective To observe the effects of caffeine and triazolam on human basic +GZ tolerance. Methods Six young volunteers with experience on centrifuge training served as subjects. The experiment was divided into two parts: ①double blind cross over protocol was used to administer 200 mg caffeine or placebo at 8:00~9:00 a.m. with 1 week interval, and their basic +GZ tolerance was measured 1 h later; ②the same protocol was used to administer triazolam or placebo with 1 week interval at 0:00~0:30, and their basic +GZ tolerance was assessed 8 h later. During +GZ tolerance test, these subjects didn't wear anti-G suits, +GZ exposure began from 2.5 G and peripheral light loss was used as end point. Immediately prior and after the G-tolerance assessment, blood pressure and pulse rate were obtained. Results The average G tolerance of the 6 subjects after taking caffeine or placebo(1 h) was (3.67±0.30) G and (3.63±0.41) G respectively; and their G tolerance after administering triazolam or placebo(8 h) was (3.92±0.34) G and (3.67±0.26) G separately. There was no significant difference. No significant changes of other parameters were observed. Conclusions There were no significant effects on human basic +GZ tolerance after taking caffeine(1 h later) and triazolam (8 h later).%目的观察咖啡因和三唑仑对人体基础+GZ耐力的影响,为战时飞行应用提供试验依据。方法试验分两批:①6名受试者于8:00~9:00随机交叉服用咖啡因200 mg和安慰剂(相隔1周)后1 h进行基础+GZ耐力测定;②6名受试者于0:00~0:30随机交叉服用三唑仑0.25 mg和安慰剂(相隔1周)后睡眠,次日上午(用药后8 h)进行基础+GZ耐力测定。受试者不着抗G服,从2.5 G开始,以周边视觉消失为耐受终点,并在+GZ暴露前后测定受试者的血压和脉搏。结果服用咖啡因与安慰剂后1 h,6名受试者的基础+GZ耐力分别为(3.67±0.30) G和(3.63±0.41) G;

  3. Human Rights and Human Nature

    Directory of Open Access Journals (Sweden)

    Vittorio Possenti

    2013-11-01

    Full Text Available There seems to be two different versions of human rights in Western tradition: say Rationalistic and Christian; the former adopted in revolutionary France, the latter highly developed in Renaissance Spain. Current relativistic criticisms attempt to deny the universality of human rights alleging that this theory has been created in Western countries or it has no strong justification, and therefore cannot have universal approach; but this objection can be dismissed with an alternative justification of human rights.

  4. Therapy for Cerebral Palsy by Human Umbilical Cord Blood Mesenchymal Stem Cells Transplantation Combined With Basic Rehabilitation Treatment: A Case Report.

    Science.gov (United States)

    Zhang, Che; Huang, Li; Gu, Jiaowei; Zhou, Xihui

    2015-01-01

    Background. Cerebral palsy (CP) is the most common cause leading to childhood disability. Human umbilical cord blood mesenchymal stem cells (hUCB-MSCs) transplantation is a promising alternative considering the safety and efficacy in current reports. This report represents a case of hUCB-MSCs transplantation combined with basic rehabilitation treatment beginning as early as age 6 months with follow-up as long as 5 years. Methods. A 6-year-old female patient was diagnosed with CP at age 6 months. The patient accepted 4 infusions of intravenous hUCB-MSCs in each course and received 4 courses of transplantation totally. A series of assessments were performed before the first transplantation, including laboratory tests, CDCC Infant Mental Development Scale, and Gross Motor Function Measure-88 (GMFM-88). Then annual assessments using the GMFM-88, Ashworth spasm assessment, and comprehensive function assessment scale were made in addition to the annual laboratory tests. In addition, electroencephalography and brain magnetic resonance imaging were conducted before transplantation and in the follow-up phase. Rehabilitation and safety follow-up have been ongoing for 5 years up to date. Results. There was no complaint about adverse effects during hospitalization or postoperative follow-up. Motor function recovered to normal level according to the evaluation of scales. Language function improved significantly. Linguistic rehabilitation therapy was enhanced for further improvement. Conclusions. The clinical application of hUC-MSCs combined with basic rehabilitation treatment was effective and safe for improving motor and comprehensive function in a patient with CP.

  5. Implementation of the Zuluaga-Raysmith (Z-R) model for assessment of perceived basic human needs in home health clients and caregivers.

    Science.gov (United States)

    Zuluaga, B H

    2000-01-01

    The Zuluaga-Raysmith (Z-R) model is a conceptual framework that incorporates accepted concepts of universal basic human needs developed by Maslow, yet removes the hierarchical nature of these. The Z-R model recognizes the existence of a health-illness continuum and accepts that an entity (individual, family, aggregate, or community) may move freely in the direction of greater health and self-actualization or towards illness and premature death. The Z-R model identifies 10 basic needs and recognizes that a perceived deficit in any one of these needs can adversely affect the level of wellness of the entity being considered. This exploratory and descriptive study used 11 nurses as interviewers. Subjects consisted of a convenience sample of homebound clients of a home health agency in a metropolitan city, and selected caregivers (n = 27). A modified functional wellness inventory (developed in 1993 by Louvenia Carter) was used with several open-ended questions, which together related to the 10 needs of the Z-R model. Reliability coefficient of the instrument was 0.84. Descriptive statistics were used to analyze the data, using means, percentages, and frequencies. Open-ended questions were grouped according to content and ranked in order of frequency. The five most pressing needs of this small sample were income; physical health; opportunity to make a contribution; mobility; and mental, emotional, social, and spiritual health (MESSH). Nurses unanimously reported that use of the instrument and the Z-R model helped them to focus on the total person, identify strengths in their clients, identify perceived needs deficits, and therefore, with the client, facilitate the preparation of a timely and cost-effective interdisciplinary plan of care to help the entity to move to a higher level of wellness despite the presence of chronic disease, disability, or impending death. These findings suggested that further research is warranted to explore the use of the Z-R model. A

  6. Co-localization and regulation of basic fibroblast growth factor and arginine vasopressin in neuroendocrine cells of the rat and human brain

    Directory of Open Access Journals (Sweden)

    Gonzalez Ana M

    2010-08-01

    Full Text Available Abstract Background Adult rat hypothalamo-pituitary axis and choroid plexus are rich in basic fibroblast growth factor (FGF2 which likely has a role in fluid homeostasis. Towards this end, we characterized the distribution and modulation of FGF2 in the human and rat central nervous system. To ascertain a functional link between arginine vasopressin (AVP and FGF2, a rat model of chronic dehydration was used to test the hypothesis that FGF2 expression, like that of AVP, is altered by perturbed fluid balance. Methods Immunohistochemistry and confocal microscopy were used to examine the distribution of FGF2 and AVP neuropeptides in the normal human brain. In order to assess effects of chronic dehydration, Sprague-Dawley rats were water deprived for 3 days. AVP neuropeptide expression and changes in FGF2 distribution in the brain, neural lobe of the pituitary and kidney were assessed by immunohistochemistry, and western blotting (FGF2 isoforms. Results In human hypothalamus, FGF2 and AVP were co-localized in the cytoplasm of supraoptic and paraventricular magnocellular neurons and axonal processes. Immunoreactive FGF2 was associated with small granular structures distributed throughout neuronal cytoplasm. Neurohypophysial FGF2 immunostaining was found in axonal processes, pituicytes and Herring bodies. Following chronic dehydration in rats, there was substantially-enhanced FGF2 staining in basement membranes underlying blood vessels, pituicytes and other glia. This accompanied remodeling of extracellular matrix. Western blot data revealed that dehydration increased expression of the hypothalamic FGF2 isoforms of ca. 18, 23 and 24 kDa. In lateral ventricle choroid plexus of dehydrated rats, FGF2 expression was augmented in the epithelium (Ab773 as immunomarker but reduced interstitially (Ab106 immunostaining. Conclusions Dehydration altered FGF2 expression patterns in AVP-containing magnocellular neurons and neurohypophysis, as well as in choroid

  7. Use of basic mobile phase to improve chromatography and boost sensitivity for quantifying tetrahydrocurcumin in human plasma by LC-MS/MS.

    Science.gov (United States)

    Tan, Aimin; Wu, Yanxin; Wong, Molly; Licollari, Albert; Bolger, Gordon; Fanaras, John C; Shopp, George; Helson, Lawrence

    2016-08-15

    Tetrahydrocurcumin (THC), a major metabolite of curcumin, is often quantified by LC-MS or LC-MS/MS using acidic mobile phases due to the concern of its instability in a basic medium. However, acidic mobile phases often lead to poor chromatography (e.g. split or double peaks) and reduced detection sensitivity in the commonly used negative ionization mode. To overcome these shortcomings, a basic mobile phase was used for the first time in the LC-MS/MS quantification of THC. In comparison with the acidic mobile phases, a single symmetrical chromatographic peak was obtained and the sensitivity increased by 7-fold or more under the equivalent conditions. The new LC-MS/MS method using the basic mobile phase has been successfully validated for the quantification of THC in human EDTA plasma over the concentration range of 5-2500ng/ml. The within-batch accuracy (% nominal concentration) was between 88.7 and 104.9 and the between-batch accuracy ranged from 96.7 to 108.6. The CVs for within- and between-batch precisions were equal to or less than 5.5% and 9.1%, respectively. No significant matrix interference or matrix effect was observed from normal or lipemic and hemolytic plasma matrices. In addition, the common stabilities with adequate durations were established, including up to 5days of post-preparative stability. Furthermore, when the validated method was applied to a clinical study, the passing rate of ISR samples was 83%, indicating the good reproducibility of the method. The success of the unconventional approach presented in this article demonstrates that a mobile phase could be selected based mainly on its merits to facilitate LC separation and/or MS detection. There is no need for excessive concern about the stability of the compound(s) of interest in the selected mobile phase because the run time of modern LC-MS or LC-MS/MS methods is typically only a few minutes.

  8. Basic Research in Human Factors

    Science.gov (United States)

    1990-07-01

    increasingly used in a variety of civilian and military systems including aircraft, ships, and omand , control and commnication centers. These displays have...IL Julian Hochberg (NAS), Columbia University David Lwargrebe, Purdue University David Neri, U.S. Navy Submarine Base, Groton, CT J.J. Rennilscn...Timothy A. Salthouse, Georgia Institute of Technology Harold L. Sheppard, University of South Florida David B.D. Smith, University of Southern California

  9. Dos pinturas de Denis Calvaert identificadas en los fondos del Museo del Prado

    Directory of Open Access Journals (Sweden)

    Diéguez Rodríguez, Ana

    2010-06-01

    Full Text Available Based on stylistic considerations, this study attributes two unpublished paintings in the Prado Museum to Denis Calvaert. This Flemish artist is not well known in Spain due to the scarcity of his works and because of a strong Italian stylistic influence, which has contributed to the incorrect attribution of his paintings.

    Atendiendo a razones de estilo este estudio da a conocer dos pinturas inéditas de Denis Calvaert entre los fondos del museo del Prado. Pintor flamenco poco conocido en España por la escueta obra que aquí se conserva, y por su fuerte influencia italiana que ha hecho que muchas de sus obras hayan estado atribuidas a esta última escuela.

  10. El iusnaturalismo formal de inspiración calvinista en la filosofía social y política de Denis de Rougemont

    Directory of Open Access Journals (Sweden)

    Joan Alfred Martínez i Segui

    2011-06-01

    Full Text Available RESUMENEl pensador Denis de Rougemont, a partir de su antropología filosófica personalista de inspiración calvinista y de una razón práctica de carácter profundamente dialógico, aporta una lectura iusfilosófica calificable de iusnaturalismo formal o deontológico. Un derecho natural humano de contenido histórico y variable, que, a modo de ética pública consensuada por la sociedad civil en el seno de los Estados democráticos de derecho, sirve de base a un prolífico civismo ciudadano, además de dar legitimación universal a los derechos humanos y representar el elemento axiológico ineludible tanto del contrato político como del conjunto del ordenamiento jurídico. ABSTRACT The philosopher Denis de Rougemont, from his personal philosophical anthropology of Calvinist inspiration and a practical reason with a deep dialogic meaning, provide a reading of philosophy of law that we can qualify as formal or deontologic natural law. A natural human law with a variable historical content, which, by way of public ethics and civil society consensus within democratic states of law, underpins a prolific citizen spiritedness, in addition to contribute to a universal legitimacy of human rights and to represent the inevitable axiological element of the political contract and the legal system.

  11. Näitleja paradoks / Denis Diderot ; tõlkinud Mirjam Lepikult

    Index Scriptorium Estoniae

    Diderot, Denis

    2006-01-01

    Järg: nr. 12, lk. 2649-2684, sisaldab katkendit Moliere' i näidendist "Armutusk" (lk. 2654-2657) ; 2007, nr. 1, lk. 121-145. Orig.: Diderot, Denis. Paradoxe sur le comédien suivi de Lettres sur le théatre a Madame Riccoboni et a Mademoiselle Jodin. ⁹dition présentée, établie et annotée par Robert Abirached. Paris : Gallimard, 1994. [Esitrükk 1830

  12. New species of Brachystomellidae and characterization of Micronella porcus (Denis, 1933) from Brazil

    Science.gov (United States)

    Queiroz, Gabriel C.; de Mendonça, Maria Cleide

    2013-01-01

    Abstract Three new species of Brachystomellidae from high altitude fields of southeast Brazil are described and illustrated and additions made to the description of Micronella porcus (Denis, 1933). The new species are Neorganella rotundatae sp. n., the second for the genus, Micronella itacaman sp. n. and Micronella longisensilla sp. n. Diagnosis of the genera have been extended. An identification key to the genus Micronella Arlé, 1959 is provided. PMID:23878516

  13. Establishing Semantic Interoperability, Under Denied, Disconnected, Intermittant, and Limited Telecommunications Conditions

    Science.gov (United States)

    2014-06-01

    always been there for me and gave me a beautiful model of hard work and perseverance. xv THIS PAGE INTENTIONALLY LEFT...efforts on Data Distribution Services (DDS) for its applicability to military IT/C2 systems operating in a denied environment. DDS is advertised ...interoperability is simply the ability to send signals or bytes through 5 a reliable physical connection. Technical integration is more feasible and less complex

  14. Literature as an exploration of the phenomenology of schizophrenia: disorder and recovery in Denis Johnson's Jesus' Son.

    Science.gov (United States)

    Hamm, Jay A; Leonhardt, Bethany L; Fogley, Rebecca L; Lysaker, Paul H

    2014-12-01

    When read as a fictional psychosis narrative, Jesus' Son, a collection of short stories by Denis Johnson, reveals important elements of the phenomenology of schizophrenia and recovery. It is possible that Jesus' Son, as a work of fiction, may be able to uniquely add depth and nuance to an understanding of the phenomenology of schizophrenia involving a state of psychological fragmentation, an ever-changing interpersonal field and a loss of personal agency. In addition, by following the protagonist in Jesus' Son as he begins to resolve some of his difficulties, the book also offers an individualised account of recovery. The authors detail how the book reveals these insights about schizophrenia and recovery and suggest that these elements are intertwined in such a manner that leads to a profound disruption of self-experience, characterised by a collapse of metacognitive processes. Jesus' Son may add depth to our understanding of the subjective experience of schizophrenia and recovery, and also may serve as one example in which the study of humanities offers an opportunity to explore the human elements in the most profound forms of suffering.

  15. Teaching Psychology in the Medical School Curriculum: Students' Perceptions of a Basic Science Course in Medical Psychology.

    Science.gov (United States)

    Krantz, David S.; And Others

    1983-01-01

    Basic science courses that emphasize relationships between behavior and health have been developed at several medical schools. Surveys of students who took these courses indicated that they were interested in the psychosocial aspects of medicine. These data deny the stereotype of the medical student who is biased against behavioral science. (CS)

  16. Mental Health Diagnoses 3 Years After Receiving or Being Denied an Abortion in the United States.

    Science.gov (United States)

    Biggs, M Antonia; Neuhaus, John M; Foster, Diana G

    2015-12-01

    We set out to assess the occurrence of new depression and anxiety diagnoses in women 3 years after they sought an abortion. We conducted semiannual telephone interviews of 956 women who sought abortions from 30 US facilities. Adjusted multivariable discrete-time logistic survival models examined whether the study group (women who obtained abortions just under a facility's gestational age limit, who were denied abortions and carried to term, who were denied abortions and did not carry to term, and who received first-trimester abortions) predicted depression or anxiety onset during seven 6-month time intervals. The 3-year cumulative probability of professionally diagnosed depression was 9% to 14%; for anxiety it was 10% to 15%, with no study group differences. Women in the first-trimester group and women denied abortions who did not give birth had greater odds of new self-diagnosed anxiety than did women who obtained abortions just under facility gestational limits. Among women seeking abortions near facility gestational limits, those who obtained abortions were at no greater mental health risk than were women who carried an unwanted pregnancy to term.

  17. Exposure to transforming growth factor-β1 after basic fibroblast growth factor promotes the fibroblastic differentiation of human periodontal ligament stem/progenitor cell lines.

    Science.gov (United States)

    Kono, Kiyomi; Maeda, Hidefumi; Fujii, Shinsuke; Tomokiyo, Atsushi; Yamamoto, Naohide; Wada, Naohisa; Monnouchi, Satoshi; Teramatsu, Yoko; Hamano, Sayuri; Koori, Katsuaki; Akamine, Akifumi

    2013-05-01

    Basic fibroblast growth factor (bFGF) is a cytokine that promotes the regeneration of the periodontium, the specialized tissues supporting the teeth. bFGF, does not, however, induce the synthesis of smooth muscle actin alpha 2 (ACTA2), type I collagen (COL1), or COL3, which are principal molecules in periodontal ligament (PDL) tissue, a component of the periodontium. We have suggested the feasibility of using transforming growth factor-β1 (TGFβ1) to induce fibroblastic differentiation of PDL stem/progenitor cells (PDLSCs). Here, we investigated the effect of the subsequent application of TGFβ1 after bFGF (bFGF/TGFβ1) on the differentiation of PDLSCs into fibroblastic cells. We first confirmed the expression of bFGF and TGFβ1 in rat PDL tissue and primary human PDL cells. Receptors for both bFGF and TGFβ1 were expressed in the human PDLSC lines 1-11 and 1-17. Exposure to bFGF for 2 days promoted vascular endothelial growth factor gene and protein expression in both cell lines and down-regulated the expression of ACTA2, COL1, and COL3 mRNA in both cell lines and the gene fibrillin 1 (FBN1) in cell line 1-11 alone. Furthermore, bFGF stimulated cell proliferation of these cell lines and significantly increased the number of cells in phase G2/M in the cell lines. Exposure to TGFβ1 for 2 days induced gene expression of ACTA2 and COL1 in both cell lines and FBN1 in cell line 1-11 alone. BFGF/TGFβ1 treatment significantly up-regulated ACTA2, COL1, and FBN1 expression as compared with the group treated with bFGF alone or the untreated control. This method might thus be useful for accelerating the generation and regeneration of functional periodontium.

  18. Comparative study of the effects of recombinant human epidermal growth factor and basic fibroblast growth factor on corneal epithelial wound healing and neovascularization in vivo and in vitro.

    Science.gov (United States)

    Yan, Limeng; Wu, Wei; Wang, Zhichong; Li, Chaoyang; Lu, Xiaohe; Duan, Hucheng; Zhou, Jin; Wang, Xiaoran; Wan, Pengxia; Song, Yiyue; Tang, Jing; Han, Yu

    2013-01-01

    This study was undertaken to investigate the effects of recombinant human epidermal growth factor (rhEGF) and basic fibroblast growth factor (bFGF) on corneal wound healing and neovascularization (CNV). The positive effects of 10 ng/ml rhEGF and bFGF on the proliferation of corneal epithelial cells (SD-HCEC1s), rabbit keratocyte cells (RKCs) and human umbilical vein endothelial cells (HUVECs) as well as the effects on the migration capacity on HUVECs were observed. An animal central corneal wound and CNV model was established in rabbits. One eye of each group was chosen randomly for topical administration of rhEGF, bFGF or normal saline, and variability in the area of corneal epithelial wound healing and CNV was observed. The optimal concentration of rhEGF and bFGF for the proliferation of corneal epithelial cells was 10 ng/ml. The promotive effect of 10 ng/ml rhEGF on the proliferation of RKCs and HUVECs was less than that of 10 ng/ml bFGF. In the animal experiment, the healing rate of the corneal epithelium in the rhEGF group was better than in the other groups on day 1. On day 3, the healing rates of the 3 groups were nearly equal. The CNV area in the rhEGF group was less than that of the bFGF group. rhEGF and bFGF both had promotive effects on corneal epithelial wound healing, but rhEGF had a weaker promotive effect on CNV than bFGF. With long-term application of growth factor drugs, rhEGF is suggested for lessening the growth of CNV. Copyright © 2012 S. Karger AG, Basel.

  19. Ameliorative effects of human adipose tissue-derived mesenchymal stem cells on myelin basic protein-induced experimental autoimmune encephalomyelitis in Lewis rats

    Institute of Scientific and Technical Information of China (English)

    Myung-Soon Ko; Hyeong-geun Park; Young-Min Yun; Jeong Chan Ra; Taekyun Shin; Kyoung-Kap Lee

    2011-01-01

    Mesenchymal stem cells have been previously shown to exert an immunomodulatory function. The present study sought to investigate the effects of multipotential human adipose tissue-derived mesenchymal stem cells (hAdMSCs) on disease progression and cytokine expression in Lewis rats with experimental autoimmune encephalomyelitis (EAE) induced by myelin basic protein. The duration of EAE paralysis in the group treated on day 7 postimmunization with 5 × 106 hAdMSCs was significantly reduced compared with the vehicle-treated controls and the 1 × 106 hAdMSC- treated group. The duration of EAE paralysis in the groups treated with 5 × 106 hAdMSCs on both day 1 and day 7 postimmunization was significantly reduced compared with the vehicle-treated controls and the groups treated with 5 × 106 hAdMSCs on both day 7 and day 10 postimmunization. The mRNA expression of interleukin-10 and indoleamine 2, 3-dioxygenase was significantly decreased in the hAdMSC-treated group compared with the vehicle-treated group. These findings suggest that the ameliorative effects of hAdMSCs on EAE symptoms operate in a dose- and time-dependent manner and can be mediated in part by the ample production of anti-inflammatory cytokines.

  20. Development and Pre-Clinical Evaluation of Recombinant Human Myelin Basic Protein Nano Therapeutic Vaccine in Experimental Autoimmune Encephalomyelitis Mice Animal Model

    Science.gov (United States)

    Al-Ghobashy, Medhat A.; Elmeshad, Aliaa N.; Abdelsalam, Rania M.; Nooh, Mohammed M.; Al-Shorbagy, Muhammad; Laible, Götz

    2017-04-01

    Recombinant human myelin basic protein (rhMBP) was previously produced in the milk of transgenic cows. Differences in molecular recognition of either hMBP or rhMBP by surface-immobilized anti-hMBP antibodies were demonstrated. This indicated differences in immunological response between rhMBP and hMBP. Here, the activity of free and controlled release rhMBP poly(ε-caprolactone) nanoparticles (NPs), as a therapeutic vaccine against multiple sclerosis (MS) was demonstrated in experimental autoimmune encephalomyelitis (EAE) animal model. Following optimization of nanoformulation, discrete spherical, rough-surfaced rhMBP NPs with high entrapment efficiency and controlled release pattern were obtained. Results indicated that rhMBP was loaded into and electrostatically adsorbed onto the surface of NPs. Subcutaneous administration of free or rhMBP NPs before EAE-induction reduced the average behavioral score in EAE mice and showed only mild histological alterations and preservation of myelin sheath, with rhMBP NPs showing increased protection. Moreover, analysis of inflammatory cytokines (IFN-γ and IL-10) in mice brains revealed that pretreatment with free or rhMBP NPs significantly protected against induced inflammation. In conclusion: i) rhMBP ameliorated EAE symptoms in EAE animal model, ii) nanoformulation significantly enhanced efficacy of rhMBP as a therapeutic vaccine and iii) clinical investigations are required to demonstrate the activity of rhMBP NPs as a therapeutic vaccine for MS.

  1. [Do women from Seine-Saint-Denis have different prenatal care compared to other women in the region?].

    Science.gov (United States)

    Carayol, M; Bucourt, M; Cuesta, J; Blondel, B; Zeitlin, J

    2015-03-01

    We compared the care of pregnant women residing in Seine-Saint-Denis (SSD) to those resident elsewhere in Île-de-France because of the high rate of perinatal and infant mortality in this district. Data come from the French national perinatal surveys of 2003 and 2010 (n=969 in Seine-Saint-Denis, n=5636 other Île-de-France). We analyzed two indicators: inadequate prenatal care (late initiation, inadequate care and 29 % and 16 % did not know if they had been screened for Down's Syndrome. These rates were higher among migrant women but did not differ by place of residence (25 and 40 % respectively). For French citizens, residence in Seine-Saint-Denis was a risk factor for both indicators. A reflection on how to improve care during pregnancy should be initiated in Seine-Saint-Denis. Copyright © 2014 Elsevier Masson SAS. All rights reserved.

  2. Menstrual Cycle: Basic Biology

    Science.gov (United States)

    Hawkins, Shannon M.; Matzuk, Martin M.

    2010-01-01

    The basic biology of the menstrual cycle is a complex, coordinated sequence of events involving the hypothalamus, anterior pituitary, ovary, and endometrium. The menstrual cycle with all its complexities can be easily perturbed by environmental factors such as stress, extreme exercise, eating disorders, and obesity. Furthermore, genetic influences such as fragile X premutations (Chapter X), X chromosome abnormalities (Chapter X), and galactose-1-phosphate uridyltransferase (GALT) point mutations (galactosemia) also contribute to perturbations of the menstrual cycle. Although not perfect, mouse model have helped to identify and confirm additional components and pathways in menstrual cycle function and dysfunction in humans. PMID:18574203

  3. Neuronal-like differentiation of single versus multiple treatments with human amnion-derived mesenchymal stem cells induced by basic fibroblast growth factor

    Institute of Scientific and Technical Information of China (English)

    Hongliang Jiao; Fangxia Guan; Xiang Hu; Jianbin Li; Hong Shan; Wei Li; Jun Li; Ying Du; Bo Yang; Yunfan Zhou

    2009-01-01

    BACKGROUND: Cultures from multiple portions of umbilical cord blood mesenchymal stem cells have been shown to undergo more rapid proliferation and attachment than single portions. OBJECTIVE: To observe growth of basic fibroblast growth factor (bFGF)-induced cultures of human amnion-derived mesenchymal stem cells (AMSCs) and differentiation into neuronal-like cells. DESIGN, TIME AND SETTING: Comparative observation. The study was performed at the Laboratory of Microbiology and Immunology, Basic Medical School of Zhengzhou University from January to May 2008.METHODS: Amnia from full-term, uterine-incision delivery were donated by 12 healthy women. AMSCs were obtained by cell separation and culture techniques, and were passaged and induced by bFGF. From the third passage, a total of 1 mL AMSCs, at a density of 1.0 ×10 4/mL, was separately harvested from six samples, which served as group A. A total of 1 mL AMSCs, at a density of 1.0×10 4 /mL, was harvested separately from the remaining six samples, which served as group B. A total of 0.5 mL from the six samples of group A and 0.5 mL from the six samples of group B were combined to form group C. MAIN OUTCOME MEASURES: Differences in cell quantity among the three groups were compared by cell quantification and 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT)analysis. Expression of a glial cell marker, neuron-specific enolase, and nestin was detected in the three groups by immunocytochemistry. RESULTS: Cell quantification and MTT analysis of live cells, as well as AMSC absorbance, were significantly greater in group C compared with groups A and B at 18 days of culture (P<0.05), and no significant difference was observed between groups A and B. Glial fibrillary acidic protein, neuron-specific enolase, and nestin were expressed in all groups following bFGF induction. CONCLUSION: Mixed AMSC cultures promoted proliferation, and bFGF-induced AMSCs differentiated into neuronal-like cells.

  4. A mutein of human basic fibroblast growth factor TGP-580 accelerates colonic ulcer healing by stimulating angiogenesis in the ulcer bed in rats.

    Science.gov (United States)

    Satoh, H; Szabo, S

    2015-10-01

    Previously, we reported that TGP-580, a mutein of human basic fibroblast growth factor (bFGF), accelerated the healing of gastric and duodenal ulcers in rats. In the present study, we examined the effect of TGP-580 on the healing of colonic ulcers. In male Sprague Dawley rats, ulcers were induced in the colon 6 cm from the anus by enema of 50 μl of 3% N-ethylmaleimide, a sulfhydryl alkylator. The lesions were examined under a dissecting microscope (x10). The concentration of bFGF in the ulcerated colon was measured by enzyme immunoassay, and both the distribution of bFGF and the density of microvessels in the ulcer bed were examined by immunohistochemical staining. The content of bFGF in the ulcerated colon was markedly increased associated with ulcer healing, and ulcer healing was significantly delayed by intravenous administration of a monoclonal antibody for bFGF (MAb 3H3) once daily for 10 days. In the ulcer bed, many cells such as fibroblasts, vascular endothelial cells and macrophages were positively stained with bFGF antiserum. TGP-580, human bFGF or dexamethasone was given intracolonally twice daily for 10 days, starting the day after ulcer induction. TGP-580 (0.2 - 20 μg/ml, 200 μl/rat) dose-dependently accelerated ulcer healing, and its effect was more than 10 times stronger than that of human bFGF. Density (μm/0.01 mm(2)) of microvessels in the ulcer bed was significantly increased by treatment with TGP-580, and there was a good correlation between the density of microvessels and the decrease of ulcerated area (R(2) = 0.633). On the other hand dexamethasone (20 μg/ml) inhibited angiogenesis in the ulcer bed and delayed ulcer healing. These results suggest that angiogenesis in the ulcer bed plays an important role in ulcer healing, and that bFGF mutein TGP-580 accelerated colonic ulcer healing, at least in part, by stimulating angiogenesis, whereas glucocorticoids may delay the healing by inhibiting angiogenesis.

  5. Access Denied

    Science.gov (United States)

    Villano, Matt

    2008-01-01

    Building access control (BAC)--a catchall phrase to describe the systems that control access to facilities across campus--has traditionally been handled with remarkably low-tech solutions: (1) manual locks; (2) electronic locks; and (3) ID cards with magnetic strips. Recent improvements have included smart cards and keyless solutions that make use…

  6. Measuring student teachers' basic psychological needs

    NARCIS (Netherlands)

    Vermeulen, Marjan; Castelijns, Jos; Kools, Quinta; Koster, Bob

    2012-01-01

    In the Self-Determination Theory (SDT) basic psychological needs for relatedness, autonomy and competence are distinguished. Basic psychological need fulfilment is considered to be critical for human development and intrinsic motivation. In the Netherlands, the concept of basic psychological need fu

  7. Measuring Student Teachers' Basic Psychological Needs

    Science.gov (United States)

    Vermeulen, Marjan; Castelijns, Jos; Kools, Quinta; Koster, Bob

    2012-01-01

    In Self-Determination Theory, basic psychological needs for relatedness, autonomy and competence are distinguished. Basic psychological need-fulfilment is considered to be critical for human development and intrinsic motivation. In the Netherlands, the concept of basic psychological need-fulfilment is introduced in the curricula of many teacher…

  8. Measuring Student Teachers' Basic Psychological Needs

    Science.gov (United States)

    Vermeulen, Marjan; Castelijns, Jos; Kools, Quinta; Koster, Bob

    2012-01-01

    In Self-Determination Theory, basic psychological needs for relatedness, autonomy and competence are distinguished. Basic psychological need-fulfilment is considered to be critical for human development and intrinsic motivation. In the Netherlands, the concept of basic psychological need-fulfilment is introduced in the curricula of many teacher…

  9. Measuring student teachers' basic psychological needs

    NARCIS (Netherlands)

    Dr. Jos Castelijns; dr Bob Koster; dr.ir. Quinta Kools; Dr. Marjan Vermeulen

    2012-01-01

    In the Self-Determination Theory (SDT) basic psychological needs for relatedness, autonomy and competence are distinguished. Basic psychological need fulfilment is considered to be critical for human development and intrinsic motivation. In the Netherlands, the concept of basic psychological need

  10. Specific Content of the Basic Human Rights Principle Recognized by China's Constitution%我国宪法确认基本人权原则具体内容之分析

    Institute of Scientific and Technical Information of China (English)

    施秀艳

    2013-01-01

      Basic human rights principle is a fundamental principle established by the constitutions of various countries in the world. Chi-na's Constitution confirms the basic human rights principle by stipulating the fundamental rights. Fundamental rights is regulated by the Constitution, which has the core status in the rights system and constitutes the basis of the common legal rights. With respective character-istics and specific content defects, all previous constitutions of China have different influences on fundamental rights. Studying the consti-tution confirmation process on the basic human rights has significant reference values in further improving the basic human rights legisla-tion and in implementing a protection system of the basic human rights.%  基本人权原则是世界各国宪法所确立的一项基本原则,我国宪法通过规定基本权利来确认基本人权原则。基本权利是由宪法规定的、在权利体系中居于核心地位,是构成普通法律权利的基础。我国历部宪法对基本权利的规定各有其特点以及具体内容方面的缺陷,从而产生了不同的影响。研究我国宪法对基本人权原则具体内容的确认过程,对今后进一步完善基本人权立法、落实基本人权保障制度具有重大的借鉴价值。

  11. Systemic lupus erythematosus: molecular cloning and analysis of 22 individual recombinant monoclonal kappa light chains specifically hydrolyzing human myelin basic protein.

    Science.gov (United States)

    Timofeeva, Anna M; Buneva, Valentina N; Nevinsky, Georgy A

    2015-10-01

    Antibodies hydrolyzing myelin basic protein (MBP) can play an important role in the pathogenesis of multiple sclerosis (MS) and systemic lupus erythematosus (SLE). An immunoglobulin light chain phagemid library derived from peripheral blood lymphocytes of patients with SLE was used. Small pools of phage particles displaying light chains with different affinities for MBP were isolated by affinity chromatography on MBP-Sepharose, and the fraction eluted with 0.5 M NaCl was used for preparation of individual monoclonal light chains (MLChs, 26-27 kDa). Seventy-two of 440 individual colonies were randomly chosen, expressed in Escherichia coli in a soluble form, and MLChs were purified by metal chelating chromatography. Twenty-two of 72 MLChs have high affinity and efficiently hydrolyze only MBP (not other control proteins) demonstrating various pH optima in a 5.7-9.0 range and different substrate specificity in the hydrolysis of four different MBP oligopeptides. Four MLChs demonstrated serine protease-like and three thiol protease-like activities, while 11 MLChs were metalloproteases. The activity of three MLChs was inhibited by both phenylmethylsulfonyl fluoride (PMSF) and Ethylenediaminetetraacetic acid (EDTA), two other by EDTA and iodoacetamide, and one by PMSF, EDTA, and iodoacetamide. The ratio of relative activity in the presence of Ca(2+), Mg(2+), Mn(2+), Ni(2+), Zn(2+), Cu(2+), and Co(2+) was individual for each of 22 MLCh preparations. It is the first examples of human MLChs, which probably can possess two or even three different proteolytic activities. These observations suggest an extreme diversity of anti-MBP abzymes in SLE patients. The immune systems of individual SLE patients can generate a variety of anti-MBP abzymes, which can attack MBP of myelin-proteolipid sheath of axons and play an important role in MS and SLE pathogenesis.

  12. Intermolecular recognition revealed by the complex structure of human CLOCK-BMAL1 basic helix-loop-helix domains with E-box DNA

    Institute of Scientific and Technical Information of China (English)

    Zixi Wang; Yaling Wu; Lanfen Li; Xiao-Dong Su

    2013-01-01

    CLOCK (circadian locomotor output cycles kaput) and BMAL1 (brain and muscle ARNT-like 1) are both transcription factors of the circadian core loop in mammals.Recently published mouse CLOCK-BMAL1 bHLH (basic helix-loop-helix)-PAS (period-ARNT-single-minded) complex structure sheds light on the mechanism for heterodimer formation,but the structural details of the protein-DNA recognition mechanisms remain elusive.Here we have elucidated the crystal structure of human CLOCK-BMAL1 bHLH domains bound to a canonical E-box DNA.We demonstrate that CLOCK and BMAL1 bHLH domains can be mutually selected,and that hydrogen-bonding networks mediate their E-box recognition.We identified a hydrophobic contact between BMAL1 Ile80 and a fianking thymine nucleotide,suggesting that CLOCK-BMAL1 actually reads 7-bp DNA and not the previously believed 6-bp DNA.To find potential non-canonical E-boxes that could be recognized by CLOCK-BMAL1,we constructed systematic single-nucleotide mutations on the E-box and measured their relevant affinities.We defined two non-canonical E-box patterns with high affinities,AACGTGA and CATGTGA,in which the flanking A7-T7' base pair is indispensable for recognition.These results will help us to identify functional CLOCK-BMAL1-binding sites in vivo and to search for clock-controlled genes.Furthermore,we assessed the inhibitory role of potential phosphorylation sites in bHLH regions.We found that the phospho-mimicking mutation on BMAL1 Ser78 could efficiently block DNA binding as well as abolish normal circadian oscillation in cells.We propose that BMAL1 Ser78 should be a key residue mediating input signal-regulated transcriptional inhibition for external cues to entrain the circadian clock by kinase cascade.

  13. Science Translational Medicine – improving human health care worldwide by providing an interdisciplinary forum for idea exchange between basic scientists and clinical research practitioners

    Directory of Open Access Journals (Sweden)

    Forsythe, Katherine

    2010-09-01

    Full Text Available Science Translational Medicine’s mission is to improve human health care worldwide by providing a forum for communication and interdisciplinary idea exchange between basic scientists and clinical research practitioners from all relevant established and emerging disciplines. The weekly journal debuted in October 2009 and is published by the American Association for the Advancement of Science (AAAS, the publisher of Science and Science Signaling. The journal features peer-reviewed research articles, perspectives and commentary, and is guided by an international Advisory Board, led by Chief Scientific Adviser, Elias A. Zerhouni, M.D., former Director of the National Institutes of Health, and Senior Scientific Adviser, Elazer R. Edelman, M.D., Ph.D., Thomas D. and Virginia W. Cabot Professor of Health Sciences and Technology, Massachusetts Institute of Technology. The Science Translational Medicine editorial team is led by Katrina L. Kelner, Ph.D., AAAS. A profound transition is required for the science of translational medicine. Despite 50 years of advances in our fundamental understanding of human biology and the emergence of powerful new technologies, the rapid transformation of this knowledge into effective health measures is not keeping pace with the challenges of global health care. Creative experimental approaches, novel technologies, and new ways of conducting scientific explorations at the interface of established and emerging disciplines are now required to an unprecedented degree if real progress is to be made. To aid in this reinvention, Science and AAAS have created a new interdisciplinary journal, Science Translational Medicine. The following interview exemplefies the pioneering content found in Science Translational Medicine. It is an excerpt from a Podcast interview with Dr. Samuel Broder, former director of the National Cancer Institute and current Chief Medical Officer at Celera. The Podcast was produced in tangent with Dr

  14. Basics of SCI Rehabilitation

    Science.gov (United States)

    ... Donate Experts \\ The Basics of Spinal Cord Injury Rehabilitation Topics Adult Injuries Spinal Cord Injury 101 Spinal ... Injury 101 The Basics of Spinal Cord Injury Rehabilitation The Basics of Spinal Cord Injury Rehabilitation Preventing ...

  15. Basic Red 51, a permitted semi-permanent hair dye, is cytotoxic to human skin cells: Studies in monolayer and 3D skin model using human keratinocytes (HaCaT).

    Science.gov (United States)

    Zanoni, Thalita B; Tiago, Manoela; Faião-Flores, Fernanda; de Moraes Barros, Silvia B; Bast, Aalt; Hageman, Geja; de Oliveira, Danielle Palma; Maria-Engler, Silvya S

    2014-06-01

    The use of hair dyes is closely associated with the increase of cancer, inflammation and other skin disorders. The recognition that human skin is not an impermeable barrier indicates that there is the possibility of human systemic exposure. The carcinogenic potential of hair dye ingredients has attracted the attention of toxicologists for many decades, mainly due to the fact that some ingredients belong to the large chemical family of aromatic amines. Herein, we investigated the cytotoxicity of Basic Red 51 (BR51) in immortalized human keratinocytes (HaCaT). BR51 is a temporary hair dye that belongs to the azo group (NN); the cleavage of this bond may result in the release of toxic aromatic amines. The half maximal effective concentration (EC50) in HaCaT cells is 13μg/mL. BR51 induced a significant decrease on expression of p21 in a dose dependent manner. p53 was not affected, whereas BR51 decreased procaspase 8 and cleaved procaspase 9. These results proved that caspase 3 is fully involved in BR51-induced apoptosis. The dye was also able to stop this cell cycle on G2 in sub-toxic doses. Moreover, we reconstructed a 3D artificial epidermis using HaCaT cells; using this model, we observed that BR51 induced cell injury and cells were undergoing apoptosis, considering the fragmented nuclei. Subsequently, BR51 induced reactive oxygen species (ROS) leading to an increase on the levels of 8-oxo-dG. In conclusion, we provide strong evidence that consumer and/or professional exposure to BR51 poses risk to human health.

  16. Denis Feissel, Chroniques d’épigraphie byzantine 1987-2004

    OpenAIRE

    Whitby, Michael

    2014-01-01

    This volume collects, in a revised, corrected and expanded form, about 1,200 annual notices of publications of Christian inscriptions from the territories of the Byzantine empire that were originally published in the Bulletin épigraphique of the Revues des Études grecques between 1987 and 2004, a period when greater and better-informed attention was paid to this material than previously. Denis Feissel was responsible for the majority of the notices, as, continuing in the footsteps of Louis Ro...

  17. Review of Saint-Denis: A Town in the Middle Ages [Website

    Directory of Open Access Journals (Sweden)

    Stephen Murray

    2011-02-01

    Full Text Available How many of us, in teaching the history of medieval urbanism, or of Gothic architecture, have lamented the all-encompassing spread of suburbs and spaghetti highways that have obliterated the shape of the medieval city with its clearly defined walls and monastic bourgs? In the 1970s, Saint-Denis was a dreary smoke-blackened industrial suburb to the north of Paris, difficult to get to from downtown, and even dangerous for the unwary visitor. The glorious history of the site was represented only by the presence of the great abbey church (now a cathedral.

  18. Posthumanism: beyond humanism?

    Science.gov (United States)

    Valera, Luca

    2014-01-01

    The focal point of posthumanism consists not as such in an a-critical acceptance of the technological promises - like there is for transhumanism - but in a total contamination and hybridization of human beings with other living beings and machines (these are the two main forms of contamination). The change of perspective untaken by posthumanism would be, thus, a paradigmatic shift in anthropology. As with ecologism, posthumanism, in order to obtain total contamination and man's openness to otherness, proposes the elimination and the fluidification of boundaries, thus even denying man's identity, and, with it, the very possibility of openness. However, by denying the identity, one denies the condition of possibility of thought, just as it has been manifested in history until now: hence we understand how, primarily, posthumanism is not configured as an adequate philosophical reflection, but as a narrative that takes origin from certain requirements, which are eminently human, and that discloses its deeply anthropogenic roots.

  19. Human resources for health: task shifting to promote basic health service delivery among internally displaced people in ethnic health program service areas in eastern Burma/Myanmar

    Directory of Open Access Journals (Sweden)

    Sharon Low

    2014-09-01

    Full Text Available Background: Burma/Myanmar was controlled by a military regime for over 50 years. Many basic social and protection services have been neglected, specifically in the ethnic areas. Development in these areas was led by the ethnic non-state actors to ensure care and the availability of health services for the communities living in the border ethnic-controlled areas. Political changes in Burma/Myanmar have been ongoing since the end of 2010. Given the ethnic diversity of Burma/Myanmar, many challenges in ensuring health service coverage among all ethnic groups lie ahead. Methods: A case study method was used to document how existing human resources for health (HRH reach the vulnerable population in the ethnic health organizations’ (EHOs and community-based organizations’ (CBHOs service areas, and their related information on training and services delivered. Mixed methods were used. Survey data on HRH, service provision, and training were collected from clinic-in-charges in 110 clinics in 14 Karen/Kayin townships through a rapid-mapping exercise. We also reviewed 7 organizational and policy documents and conducted 10 interviews and discussions with clinic-in-charges. Findings: Despite the lack of skilled medical professionals, the EHOs and CBHOs have been serving the population along the border through task shifting to less specialized health workers. Clinics and mobile teams work in partnership, focusing on primary care with some aspects of secondary care. The rapid-mapping exercise showed that the aggregate HRH density in Karen/Kayin state is 2.8 per 1,000 population. Every mobile team has 1.8 health workers per 1,000 population, whereas each clinic has between 2.5 and 3.9 health workers per 1,000 population. By reorganizing and training the workforce with a rigorous and up-to-date curriculum, EHOs and CBHOs present a viable solution for improving health service coverage to the underserved population. Conclusion: Despite the chronic conflict in

  20. Human resources for health: task shifting to promote basic health service delivery among internally displaced people in ethnic health program service areas in eastern Burma/Myanmar

    Science.gov (United States)

    Low, Sharon; Tun, Kyaw Thura; Mhote, Naw Pue Pue; Htoo, Saw Nay; Maung, Cynthia; Kyaw, Saw Win; Shwe Oo, Saw Eh Kalu; Pocock, Nicola Suyin

    2014-01-01

    Background Burma/Myanmar was controlled by a military regime for over 50 years. Many basic social and protection services have been neglected, specifically in the ethnic areas. Development in these areas was led by the ethnic non-state actors to ensure care and the availability of health services for the communities living in the border ethnic-controlled areas. Political changes in Burma/Myanmar have been ongoing since the end of 2010. Given the ethnic diversity of Burma/Myanmar, many challenges in ensuring health service coverage among all ethnic groups lie ahead. Methods A case study method was used to document how existing human resources for health (HRH) reach the vulnerable population in the ethnic health organizations’ (EHOs) and community-based organizations’ (CBHOs) service areas, and their related information on training and services delivered. Mixed methods were used. Survey data on HRH, service provision, and training were collected from clinic-in-charges in 110 clinics in 14 Karen/Kayin townships through a rapid-mapping exercise. We also reviewed 7 organizational and policy documents and conducted 10 interviews and discussions with clinic-in-charges. Findings Despite the lack of skilled medical professionals, the EHOs and CBHOs have been serving the population along the border through task shifting to less specialized health workers. Clinics and mobile teams work in partnership, focusing on primary care with some aspects of secondary care. The rapid-mapping exercise showed that the aggregate HRH density in Karen/Kayin state is 2.8 per 1,000 population. Every mobile team has 1.8 health workers per 1,000 population, whereas each clinic has between 2.5 and 3.9 health workers per 1,000 population. By reorganizing and training the workforce with a rigorous and up-to-date curriculum, EHOs and CBHOs present a viable solution for improving health service coverage to the underserved population. Conclusion Despite the chronic conflict in Burma/Myanmar, this

  1. Comparison of human dermal fibroblasts (HDFs) growth rate in culture media supplemented with or without basic fibroblast growth factor (bFGF).

    Science.gov (United States)

    Abdian, Narges; Ghasemi-Dehkordi, Payam; Hashemzadeh-Chaleshtori, Morteza; Ganji-Arjenaki, Mahbobe; Doosti, Abbas; Amiri, Beheshteh

    2015-12-01

    Basic fibroblast growth factor (bFGF or FGF-2) is a member of the FGF family secreted by different kinds of cells like HDFs and it is an important nutritional factor for cell growth and differentiation. The HDFs release bFGF in culture media at very low. The present study aims to investigate the HDFs growth rate in culture media supplemented either with or without bFGF. In brief, HDFs were isolated from human foreskin sample and were cultured in vitro in media containing bFGF and lack of this factor. The cells growth rate was calculated by trypan blue. The karyotyping was performed using G-banding to investigate the chromosomal abnormality of HDFs in both groups. Total RNA of each groups were extracted and cDNA samples were synthesized then, real-time Q-PCR was used to measure the expression level of p27kip1 and cyclin D1 genes normalized to internal control gene (GAPDH). The karyotype analysis showed that HDFs cultured in media or without bFGF had normal karyotype (46 chromosomes, XY) and chromosomal abnormalities were not observed. The cell growth rates in both groups were normal with proliferated exponentially but the slope of growth curve in HDFs cultured in media containing bFGF was increased. Karyotyp test showed that bFGF does not affect on cytogenetic stability of cells. The survey of p27kip1 and cyclin D1 genes by real-time Q-PCR showed that the expression level of these genes were up-regulated when adding bFGF in culture media (p media with growth factor like bFGF could enhance the proliferation and differentiation capacity of cells and improve cells growth rate. Similarly, fibroblast growth factors did not induce any chromosomal abnormality in cells. Furthermore, in HDFs cultured in bFGF supplemented media, the p27kip1 and cyclin D1 genes were up-regulated and suggesting an important role for bFGF in cell-cycle regulation and progression and fibroblast division stimulation. It also suggests that the effects of bFGF on different cell types with

  2. Human resources for health: task shifting to promote basic health service delivery among internally displaced people in ethnic health program service areas in eastern Burma/Myanmar.

    Science.gov (United States)

    Low, Sharon; Tun, Kyaw Thura; Mhote, Naw Pue Pue; Htoo, Saw Nay; Maung, Cynthia; Kyaw, Saw Win; Shwe Oo, Saw Eh Kalu; Pocock, Nicola Suyin

    2014-01-01

    Burma/Myanmar was controlled by a military regime for over 50 years. Many basic social and protection services have been neglected, specifically in the ethnic areas. Development in these areas was led by the ethnic non-state actors to ensure care and the availability of health services for the communities living in the border ethnic-controlled areas. Political changes in Burma/Myanmar have been ongoing since the end of 2010. Given the ethnic diversity of Burma/Myanmar, many challenges in ensuring health service coverage among all ethnic groups lie ahead. A case study method was used to document how existing human resources for health (HRH) reach the vulnerable population in the ethnic health organizations' (EHOs) and community-based organizations' (CBHOs) service areas, and their related information on training and services delivered. Mixed methods were used. Survey data on HRH, service provision, and training were collected from clinic-in-charges in 110 clinics in 14 Karen/Kayin townships through a rapid-mapping exercise. We also reviewed 7 organizational and policy documents and conducted 10 interviews and discussions with clinic-in-charges. Despite the lack of skilled medical professionals, the EHOs and CBHOs have been serving the population along the border through task shifting to less specialized health workers. Clinics and mobile teams work in partnership, focusing on primary care with some aspects of secondary care. The rapid-mapping exercise showed that the aggregate HRH density in Karen/Kayin state is 2.8 per 1,000 population. Every mobile team has 1.8 health workers per 1,000 population, whereas each clinic has between 2.5 and 3.9 health workers per 1,000 population. By reorganizing and training the workforce with a rigorous and up-to-date curriculum, EHOs and CBHOs present a viable solution for improving health service coverage to the underserved population. Despite the chronic conflict in Burma/Myanmar, this report provides evidence of the substantive

  3. Basic fibroblast growth factor induces matrix metalloproteinase-13 via ERK MAP kinase-altered phosphorylation and sumoylation of Elk-1 in human adult articular chondrocytes

    Directory of Open Access Journals (Sweden)

    Hee-Jeong Im

    2009-10-01

    Full Text Available Hee-Jeong Im,1–4 Andrew D Sharrocks,5 Xia Lin,6 Dongyao Yan,1 Jaesung Kim,1 Andre J van Wijnen,7 Robert A Hipskind81Departments of Biochemistry, 2Internal Medicine, 3Section of Rheumatology, Orthopedic Surgery, 4Rush University Medical Center, and Department of Bioengineering; University of Illinois at Chicago, IL USA; 5Faculty of Life Sciences, University of Manchester, Oxford Rd, Manchester, UK; 6Michael D DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA; 7Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA, USA; 8Institute De Genetique Moleculaire de Montpellier, FranceAbstract: Degradation of the extracellular matrix (ECM by matrix metalloproteinases (MMPs and release of basic fibroblast growth factor (bFGF are principal aspects of the pathology of osteoarthritis (OA. ECM disruption leads to bFGF release, which activates the extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK pathway and its downstream target the Ets-like transcription factor Elk-1. Previously we demonstrated that the bFGF-ERK-Elk-1 signaling axis is responsible for the potent induction of MMP-13 in human primary articular chondrocytes. Here we report that, in addition to phosphorylation of Elk-1, dynamic posttranslational modification of Elk-1 by small ubiquitin-related modifier (SUMO serves as an important mechanism through which MMP-13 gene expression is regulated. We show that bFGF activates Elk-1 mainly through the ERK pathway and that increased phosphorylation of Elk-1 is accompanied by decreased conjugation of SUMO to Elk-1. Reporter gene assays reveal that phosphorylation renders Elk-1 competent for induction of MMP-13 gene transcription, while sumoylation has the opposite effect. Furthermore, we demonstrate that the SUMO-conjugase Ubc9 acts as a key mediator for Elk-1 sumoylation. Taken together, our results suggest that sumoylation antagonizes the phosphorylation

  4. Basic and clinical immunology

    Science.gov (United States)

    Chinen, Javier; Shearer, William T.

    2003-01-01

    Progress in immunology continues to grow exponentially every year. New applications of this knowledge are being developed for a broad range of clinical conditions. Conversely, the study of primary and secondary immunodeficiencies is helping to elucidate the intricate mechanisms of the immune system. We have selected a few of the most significant contributions to the fields of basic and clinical immunology published between October 2001 and October 2002. Our choice of topics in basic immunology included the description of T-bet as a determinant factor for T(H)1 differentiation, the role of the activation-induced cytosine deaminase gene in B-cell development, the characterization of CD4(+)CD25(+) regulatory T cells, and the use of dynamic imaging to study MHC class II transport and T-cell and dendritic cell membrane interactions. Articles related to clinical immunology that were selected for review include the description of immunodeficiency caused by caspase 8 deficiency; a case series report on X-linked agammaglobulinemia; the mechanism of action, efficacy, and complications of intravenous immunoglobulin; mechanisms of autoimmunity diseases; and advances in HIV pathogenesis and vaccine development. We also reviewed two articles that explore the possible alterations of the immune system caused by spaceflights, a new field with increasing importance as human space expeditions become a reality in the 21st century.

  5. A comparison of depression and anxiety symptom trajectories between women who had an abortion and women denied one.

    Science.gov (United States)

    Foster, D G; Steinberg, J R; Roberts, S C M; Neuhaus, J; Biggs, M A

    2015-07-01

    This study prospectively assesses the mental health outcomes among women seeking abortions, by comparing women having later abortions with women denied abortions, up to 2 years post-abortion seeking. We present the first 2 years of a 5-year telephone interview study that is following 956 women who sought an abortion from 30 facilities throughout the USA. We use adjusted linear mixed-effects regression analyses to assess whether symptoms of depression and anxiety, as measured by the Brief Symptom Inventory-short form and the Primary Care Evaluation of Mental Disorders Patient Health Questionnaire, differ over time among women denied an abortion due to advanced gestational age, compared with women who received abortions. Baseline predicted mean depressive symptom scores for women denied abortion (3.07) were similar to women receiving an abortion just below the gestational limit (2.86). Depressive symptoms declined over time, with no difference between groups. Initial predicted mean anxiety symptoms were higher among women denied care (2.59) than among women who had an abortion just below the gestational limit (1.91). Anxiety levels in the two groups declined and converged after 1 year. Women who received an abortion had similar or lower levels of depression and anxiety than women denied an abortion. Our findings do not support the notion that abortion is a cause of mental health problems.

  6. 'This Is Real Misery': Experiences of Women Denied Legal Abortion in Tunisia.

    Science.gov (United States)

    Hajri, Selma; Raifman, Sarah; Gerdts, Caitlin; Baum, Sarah; Foster, Diana Greene

    2015-01-01

    Barriers to accessing legal abortion services in Tunisia are increasing, despite a liberal abortion law, and women are often denied wanted legal abortion services. In this paper, we seek to explore the reasons for abortion denial and whether these reasons had a legal or medical basis. We also identify barriers women faced in accessing abortion and make recommendations for improved access to quality abortion care. We recruited women immediately after they had been turned away from legal abortion services at two facilities in Tunis, Tunisia. Thirteen women consented to participate in qualitative interviews two months after they were turned away from the facility. Women were denied abortion care on the day they were recruited due to three main reasons: gestational age, health conditions, and logistical barriers. Nine women ultimately terminated their pregnancies at another facility, and four women carried to term. None of the women attempted illegal abortion services or self-induction. Further research is needed in order to assess abortion denial from the perspective of providers and medical staff.

  7. Galaxies with DENIS Preliminary star\\/galaxy separation and first results

    CERN Document Server

    Mamon, G A; Tricottet, M; Banchet, V

    1997-01-01

    The numerous extragalactic and cosmological motivations of the DENIS and 2MASS near infrared surveys are outlined. The performance of the DENIS survey is estimated from 50 deg^2 of high galactic latitude data (20 deg < |b| < 60 deg). Simple star/galaxy separation methods are presented and comparison with 300 visually classified objects as well as COSMOS and APM classifications. We find that the peak intensity over isophotal area is an excellent star/galaxy separation algorithm, fairly robust to variations of the PSF within the frames, achieving 98.5% completeness and 92.5% reliability for I < 16.5, in comparison with visual classification. A new estimate of the photometric accuracy for galaxies is presented. The limiting factors for homogeneous galaxy extraction at high galactic latitudes are completeness and photometric accuracy in K, photometric accuracy in J and star/galaxy separation in I (also used for classification in J and K). Galaxy counts are presented on 50 deg^2. The I counts are in excel...

  8. DENIS J081730.0-615520: An overlooked mid-T dwarf in the solar neighborhood

    CERN Document Server

    Artigau, Étienne; Folkes, Stuart; Jayawardhana, Ray; Kurtev, Radostin; Lafrenière, David; Doyon, René; Borissova, Jura

    2010-01-01

    Recent wide-field near-infrared surveys have uncovered a large number of cool brown dwarfs, extending the temperature sequence down to less than 500 K and constraining the faint end of the luminosity function. One interesting implication of the derived luminosity function is that the brown dwarf census in the immediate (<10 pc) solar neighborhood is still largely incomplete, and some bright (J<16) brown dwarfs remain to be identified in existing surveys. These objects are especially interesting as they are the ones that can be studied in most detail, especially with techniques that require large fluxes (e.g. time-variability, polarimetry, high-resolution spectroscopy) that cannot realistically be applied to objects uncovered by deep surveys. By cross-matching the DENIS and the 2MASS point-source catalogs, we have identified an overlooked brown dwarf -DENIS J081730.0-615520- that is the brightest field mid-T dwarf in the sky (J = 13.6). We present astrometry and spectroscopy follow-up observations of thi...

  9. FLAIR-II spectroscopy of two DENIS J-band galaxy samples

    CERN Document Server

    Mamon, G A; Proust, D; Mamon, Gary A.; Parker, Quentin A.; Proust, Dominique

    2001-01-01

    As a pilot survey for the forthcoming 6dF Galaxy Redshift Survey, spectroscopy of galaxies selected in J (1.2 mu) with the DENIS survey was performed at the UKST using the FLAIR II multi-object spectroscope. 69 galaxy redshifts (z's) were obtained in a high |b| field and an additional 12 z's in a low latitude (b=-17 deg), obscured field. This study illustrates the feasibility of obtaining z's with optical spectra on galaxies selected at much longer wavelengths. It validated a very preliminary algorithm for star/galaxy separation for high |b| DENIS objects, with 99% reliability for J < 13.9. However, the FLAIR II z determinations required substantially longer integration times to achieve 90% completeness than expected from previous optical surveys at comparable depth. This is mainly due to a degradation in overall fibre throughput due to known problems with ageing of the prism-cement-fibre interface with exposure to UV light. Our low |b| (high extinction) field required 2.5 times more exposure time for less...

  10. The Hox complex - an interview with Denis Duboule. Interviewed by Richardson, Michael K.

    Science.gov (United States)

    Duboule, Denis

    2009-01-01

    Denis Duboule is one of the most influential and highly-cited scientists in developmental biology. Born in Geneva in 1955, he holds dual Swiss and French nationality. His undergraduate studies in biology at the University of Geneva included research on mouse embryology. He later learned molecular techniques in the laboratory of Pierre Chambon, becoming a major player in characterising the newly-discovered vertebrate Hox genes. He helped discover their genomic clustering, realising that they had arisen by trans duplication. With Gaunt and Sharpe, he proposed that vertebrate Hox clusters might show spatial colinearity, and subsequently extended this concept to the timing of gene activation (temporal colinearity). Along with the Krumlauf laboratory, he reported the structural and functional conservation of the homeotic systems in flies and vertebrates. His lab was the first to describe nested patterns of Hox gene expression in the developing mouse limb, and later showed that digit-associated Hoxd gene expression was lacking in zebrafish paired fin development. His concept of phylotypic progression helps explain major evolutionary developmental phenomena in terms of Hox gene regulatory networks. His research helped reveal that the genital tubercle may, like the limb, be patterned by Hox genes. His lab developed targeted meiotic recombination (TAMERE), using it to make profound advances in our understanding of Hox gene regulation. Remote enhancers linked to digit patterning have been uncovered, together with a likely mechanism for colinearity. Denis lives in Geneva with his wife Brigitte Galliot, also a scientist, with their four children.

  11. 'This Is Real Misery': Experiences of Women Denied Legal Abortion in Tunisia.

    Directory of Open Access Journals (Sweden)

    Selma Hajri

    Full Text Available Barriers to accessing legal abortion services in Tunisia are increasing, despite a liberal abortion law, and women are often denied wanted legal abortion services. In this paper, we seek to explore the reasons for abortion denial and whether these reasons had a legal or medical basis. We also identify barriers women faced in accessing abortion and make recommendations for improved access to quality abortion care. We recruited women immediately after they had been turned away from legal abortion services at two facilities in Tunis, Tunisia. Thirteen women consented to participate in qualitative interviews two months after they were turned away from the facility. Women were denied abortion care on the day they were recruited due to three main reasons: gestational age, health conditions, and logistical barriers. Nine women ultimately terminated their pregnancies at another facility, and four women carried to term. None of the women attempted illegal abortion services or self-induction. Further research is needed in order to assess abortion denial from the perspective of providers and medical staff.

  12. Transportation Emissions: some basics

    DEFF Research Database (Denmark)

    Kontovas, Christos A.; Psaraftis, Harilaos N.

    2016-01-01

    Transportation is the backbone of international trade and a key engine driving globalization. However, there is growing concern that the Earth’s atmospheric composition is being altered by human activities, including transportation, which can lead to climate change. Air pollution from...... transportation and especially carbon dioxide emissions are at the center stage of discussion by the world community through various international treaties, such as the Kyoto Protocol. The transportation sector also emits non-CO2 pollutants that have important effects on air quality, climate, and public health...... and its contribution to climate change. In addition, this chapter presents the basics of environmental policy measures. In that context, we describe a way to measure the cost-effectiveness of various measures through the so-called Marginal Abatement Cost (MAC). Finally, the chapter deals with the topic...

  13. [Toward a methodology to popularize human rights for women].

    Science.gov (United States)

    Suarez, M; Arroyo, R

    1993-01-01

    The popularization of the rights of women refers to the process by which women join the historical struggle for their basic human rights on the individual and social, public and private, national and international levels. In Central America, a methodology was recently developed for reconceptualizing human rights of women and constructing these rights based on systematizing experiences from daily life. The methodology has been used in several workshops and courses in countries of the region. The methodology has four specific objectives: to identify the principal rights that have been denied to women, to identify rights achieved by women in their daily lives through their own efforts, to contribute to a new form of human rights education for women in which human rights instruments are conceived as instruments to satisfy human needs, and to develop strategies for achieving full exercise of rights. Steps in applying the methodology include encouraging participants to recall their first awareness that a human right was denied because of sex, and to recall the first time they ever successfully asserted a right. These remembered incidences then become the objects of a search through international and national human rights instruments to see whether the relevant rights are mentioned. Since most of the recollected experiences will have occurred in the domestic sphere, they will not be recognized in the instruments. The next step is to identify actions and strategies to overcome the limitations resulting from the separation of public and private spheres and to achieve recognition of the actual life experiences of women. The final step requires sharing fears and concerns regarding the implementation of the suggested strategies and actions.

  14. Basic science of osteoarthritis.

    Science.gov (United States)

    Cucchiarini, Magali; de Girolamo, Laura; Filardo, Giuseppe; Oliveira, J Miguel; Orth, Patrick; Pape, Dietrich; Reboul, Pascal

    2016-12-01

    Osteoarthritis (OA) is a prevalent, disabling disorder of the joints that affects a large population worldwide and for which there is no definitive cure. This review provides critical insights into the basic knowledge on OA that may lead to innovative end efficient new therapeutic regimens. While degradation of the articular cartilage is the hallmark of OA, with altered interactions between chondrocytes and compounds of the extracellular matrix, the subchondral bone has been also described as a key component of the disease, involving specific pathomechanisms controlling its initiation and progression. The identification of such events (and thus of possible targets for therapy) has been made possible by the availability of a number of animal models that aim at reproducing the human pathology, in particular large models of high tibial osteotomy (HTO). From a therapeutic point of view, mesenchymal stem cells (MSCs) represent a promising option for the treatment of OA and may be used concomitantly with functional substitutes integrating scaffolds and drugs/growth factors in tissue engineering setups. Altogether, these advances in the fundamental and experimental knowledge on OA may allow for the generation of improved, adapted therapeutic regimens to treat human OA.

  15. Landmark-based robust navigation for tactical UGV control in GPS-denied communication-degraded environments

    Science.gov (United States)

    Endo, Yoichiro; Balloch, Jonathan C.; Grushin, Alexander; Lee, Mun Wai; Handelman, David

    2016-05-01

    Control of current tactical unmanned ground vehicles (UGVs) is typically accomplished through two alternative modes of operation, namely, low-level manual control using joysticks and high-level planning-based autonomous control. Each mode has its own merits as well as inherent mission-critical disadvantages. Low-level joystick control is vulnerable to communication delay and degradation, and high-level navigation often depends on uninterrupted GPS signals and/or energy-emissive (non-stealth) range sensors such as LIDAR for localization and mapping. To address these problems, we have developed a mid-level control technique where the operator semi-autonomously drives the robot relative to visible landmarks that are commonly recognizable by both humans and machines such as closed contours and structured lines. Our novel solution relies solely on optical and non-optical passive sensors and can be operated under GPS-denied, communication-degraded environments. To control the robot using these landmarks, we developed an interactive graphical user interface (GUI) that allows the operator to select landmarks in the robot's view and direct the robot relative to one or more of the landmarks. The integrated UGV control system was evaluated based on its ability to robustly navigate through indoor environments. The system was successfully field tested with QinetiQ North America's TALON UGV and Tactical Robot Controller (TRC), a ruggedized operator control unit (OCU). We found that the proposed system is indeed robust against communication delay and degradation, and provides the operator with steady and reliable control of the UGV in realistic tactical scenarios.

  16. Health Insurance Basics

    Science.gov (United States)

    ... Can I Help Someone Who's Being Bullied? Volunteering Health Insurance Basics KidsHealth > For Teens > Health Insurance Basics Print ... thought advanced calculus was confusing. What Exactly Is Health Insurance? Health insurance is a plan that people buy ...

  17. Basic Research Firing Facility

    Data.gov (United States)

    Federal Laboratory Consortium — The Basic Research Firing Facility is an indoor ballistic test facility that has recently transitioned from a customer-based facility to a dedicated basic research...

  18. Systems and Methods for Locating a Target in a GPS-Denied Environment

    Science.gov (United States)

    Murdock, Ronald G. (Inventor); Mackay, John D. (Inventor); Cummins, Douglas A. (Inventor)

    2017-01-01

    A system for locating an object in a GPS-denied environment includes first and second stationary nodes of a network and an object out of synchronization with a common time base of the network. The system includes one or more processors that are configured to estimate distances between the first stationary node and the object and a distance between the second stationary node and the object by comparing time-stamps of messages relayed between the object and the nodes. A position of the object can then be trilaterated using a location of each of the first and second stationary nodes and the measured distances between the object and each of the first and second stationary nodes.

  19. Violência e intolerância em Albert Camus e Denis Diderot

    Directory of Open Access Journals (Sweden)

    Nilson Adauto Guimarães da Silva

    2013-05-01

    Full Text Available No presente artigo abordamos alguns temas dos ensaios filosóficos, O Mito de Sísifo e O Homem revoltado, e dos romances, O Estrangeiro e A Peste, de Albert Camus (1913-1960; bem como tratamos, de maneira bastante geral, o romance Jacques, o fatalista e seu amo, de Denis Diderot (1713-1784. Buscamos explicitar o engajamento dos autores o aspecto crítico de suas obras. Identificamos uma relação entre as noções camusianas de absurdo e revolta e a defesa da dignidade humana, em oposição ao dogmatismo e ao totalitarismo. Destacamos em Diderot a liberdade de pensamento e o senso crítico, como antídotos ao fanatismo, à intolerância e à violência.

  20. S-Denying of the Signature Conditions Expands General Relativity's Space

    Directory of Open Access Journals (Sweden)

    Rabounski D.

    2006-07-01

    Full Text Available We apply the S-denying procedure to signature conditions in a four-dimensional pseudo-Riemannian space — i. e. we change one (or even all of the conditions to be partially true and partially false. We obtain five kinds of expanded space-time for General Relativity. Kind I permits the space-time to be in collapse. Kind II permits the space-time to change its own signature. Kind III has peculiarities, linked to the third signature condition. Kind IV permits regions where the metric fully degenerates: there may be non-quantum teleportation, and a home for virtual photons. Kind V is common for kinds I, II, III, and IV.

  1. Basic Cake Decorating Workbook.

    Science.gov (United States)

    Bogdany, Mel

    Included in this student workbook for basic cake decorating are the following: (1) Drawings of steps in a basic way to ice a layer cake, how to make a paper cone, various sizes of flower nails, various sizes and types of tin pastry tubes, and special rose tubes; (2) recipes for basic decorating icings (buttercream, rose paste, and royal icing);…

  2. Quantitative analysis using ELISA of vascular endothelial growth factor and basic fibroblast growth factor in human colorectal cancer, liver metastasis of colorectal cancer and hepatocellular carcinoma

    Institute of Scientific and Technical Information of China (English)

    Muriel Mathonnet; Bernard Descottes; Denis Valleix; Fran(c)ois Labrousse; Véronique Truffinet; Yves Denizot

    2006-01-01

    @@ TO THE EDITOR Angiogenesis consists of the sprouting of capillaries from pre-existing vessels[1]. It is well-known that tumor growth is angiogenesis-dependent. Vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF)stimulated vascular endothelial cell proliferation and are involved in the neoplastic angiogenesis of several types of tumors including those of the intestinal tract[1-5].

  3. Basic Needs and the Division of Labour

    OpenAIRE

    GUY STANDING

    1980-01-01

    In the basic needs literature remarkably little critical attention has been devoted to the role of labour. In this paper the prevailing dominant approach to the notion of basic needs and t)1e basic needs 'strategy' of development is criticised, primarily for neglecting human labour as a central, integrating life activity. It is argued that two alternative 'visions' of development exist which imply different perspectives on 'employment'. The paper then considers what should be the crucial elem...

  4. The advantages of micro-credit lending programs and the human capabilities approach for women’s poverty reduction and increased human rights in Bangladesh

    Directory of Open Access Journals (Sweden)

    Rouf, Kazi Abdur

    2012-02-01

    Full Text Available Fifty percent of people all over the world are suffering from a lack basic needs. Even poor women are denied their equality of human rights. Equality of rights for these women would mean access to food, clothing, shelter, and credit as well as liberation from exploitative forms of income generation such as domestic work, child labor and trafficking. Women in Bangladesh suffer from inequality of rights on quite an unimaginable level and their socio-economic development has been largely impeded. Thus, these poor women depend on others to survive. Human capability services like education and skills development services are not generated nor tailored to them particularly at the village level which affects the basic human rights of these women. Without educational, health, economic and social services at the village grass-roots level, poor people suffer most in Bangladesh. Although the Constitution of Bangladesh appears to strongly approve gender equality and positive action that guarantees women’s full participation in social, economic and political life, it is clear that full support is absent. Ironically, the disadvantaged poor people specifically are struggling to fulfill their basic human needs and are aware of their basic human rights. Although some steps have been made to reduce gender inequality, some laws still lag behind and many discriminatory practices are found in the customary laws, which still remain in force. A solution that has offered to assist poor women in Bangladesh through micro-credit organizations (MFIs like Grameen Bank credit, that create opportunities for these women to help educate themselves and overcome poverty in Bangladesh. However, human rights education at the grass roots level is very nominal. Hence focus on human rights education extension programs are urgently required to establish basic human rights.

  5. Transformative combinations: women's health and human rights.

    Science.gov (United States)

    Yamin, A E

    1997-01-01

    From the human rights perspective proposed in this article, a woman's good or ill health reflects more than biology or individual behaviors; it reflects her enjoyment (or lack thereof) of fundamental human rights that enable her to exercise basic power over the course and quality of her life. The "structural" view of health that such a human rights perspective suggests is concerned first with identifying the effects of social, economic, and political relations on women's health and then with promoting "interventions" aimed at transforming the laws, institutions, and structures that deny women's rights and well-being. Yet, traditional human rights law and practice have been limited to narrowly defined abuses by public officials against individuals that fail to capture the most pervasive denials of women's rights, which, though rooted in systematic discrimination, are frequently played out in so-called "private" institutions, primarily within the family. The experiences of women's health advocates in addressing complex women's health issues makes it clear that women's lack of access to economic and political power in the public sphere creates the conditions under which they are discriminated against and physically and sexually abused in the private sphere. Combining the pragmatic understanding of women's health professionals with an expansive conception of human rights norms has the potential to transform the fields of women's health and human rights.

  6. Beginning Visual Basic 2010

    CERN Document Server

    Willis, Thearon

    2010-01-01

    A focused, step-by-step approach to Visual Basic for new programmers. What better way to get started with Visual Basic than with this essential Wrox beginner's guide? Beginning Microsoft Visual Basic 2010 not only shows you how to write Windows applications, Web applications with ASP.NET, and Windows mobile and embedded CE apps with Visual Basic 2010, but you'll also get a thorough grounding in the basic nuts-and-bolts of writing good code. You'll be exposed to the very latest VB tools and techniques with coverage of both the Visual Studio 2010 and .NET 4 releases. Plus, the book walks you ste

  7. 41 CFR 301-53.6 - Is a denied boarding benefit considered a promotional item for which I may retain compensation...

    Science.gov (United States)

    2010-07-01

    ... benefit considered a promotional item for which I may retain compensation received from an airline whether....6 Is a denied boarding benefit considered a promotional item for which I may retain compensation received from an airline whether voluntary or involuntary? A denied boarding benefit (e.g., cash, free...

  8. 40 CFR 270.185 - For what reasons may the Director choose to terminate my final RAP, or deny my renewal application?

    Science.gov (United States)

    2010-07-01

    ... choose to terminate my final RAP, or deny my renewal application? 270.185 Section 270.185 Protection of... PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) How May My Rap Be Modified... final RAP, or deny my renewal application? The Director may terminate your final RAP on his own...

  9. 40 CFR 270.145 - What are the procedures for public comment on the draft RAP or notice of intent to deny?

    Science.gov (United States)

    2010-07-01

    ... comment on the draft RAP or notice of intent to deny? 270.145 Section 270.145 Protection of Environment... HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.145 What are the procedures for public comment on the draft RAP or notice of intent to deny? (a) The Director must: (1) Send...

  10. 40 CFR 270.140 - What else must the Director prepare in addition to the draft RAP or notice of intent to deny?

    Science.gov (United States)

    2010-07-01

    ... addition to the draft RAP or notice of intent to deny? 270.140 Section 270.140 Protection of Environment... HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.140 What else must the Director prepare in addition to the draft RAP or notice of intent to deny? Once the Director has...

  11. 32 CFR 1636.8 - Considerations relevant to granting or denying a claim for classification as a conscientious...

    Science.gov (United States)

    2010-07-01

    ... claim for classification as a conscientious objector. 1636.8 Section 1636.8 National Defense Other Regulations Relating to National Defense SELECTIVE SERVICE SYSTEM CLASSIFICATION OF CONSCIENTIOUS OBJECTORS § 1636.8 Considerations relevant to granting or denying a claim for classification as a...

  12. 75 FR 67086 - Sabine Pass Liquefaction, LLC; Opinion and Order Denying Request for Review Under Section 3(c) of...

    Science.gov (United States)

    2010-11-01

    ... Sabine Pass Liquefaction, LLC; Opinion and Order Denying Request for Review Under Section 3(c) of the... opinion and order pursuant to section 3 of the Natural Gas Act (NGA), that Sabine Pass Liquefaction, LLC's (Sabine Pass) pending application of September 7, 2010, in DOE/FE Docket No. 10-111 LNG for...

  13. 78 FR 19194 - P&P Computers, 2531 West Maryland Avenue, Tampa, FL 33629; Order Denying Export Privileges

    Science.gov (United States)

    2013-03-29

    ... Bureau of Industry and Security P&P Computers, 2531 West Maryland Avenue, Tampa, FL 33629; Order Denying... Division, P&P Computers (``P&P'') was convicted of violating the International Emergency Economic Powers... IEEPA and the Iranian Transactions Regulations by exporting computer and related equipment from...

  14. Discovery of Lobesia botrana (Denis & Schiffermuller) in California: an invasive species new to North America (Lepidoptera: Tortricidae)

    Science.gov (United States)

    The European grape berry moth, Lobesia botrana (Denis and Schiffermüller), is one of the most destructive pests of grapes in the Palearctic Region. Larvae feed on the fruit, causing direct damage and promoting secondary infection by Botrytis cinerea Persoon (botrytis bunch rot or gray mold). On 15 S...

  15. Embodying Art and Art History: An Experiment with a Class Video Happening for the Series "Access Denied"

    Science.gov (United States)

    Cempellin, Leda

    2013-01-01

    A book written in a foreign language and migrated to the US along with its author, an art historian, finds a new communicative dimension by becoming a ready-made for art making purposes. Starting with an introduction explaining the genesis of the collaborative project "Access Denied," this article focuses on one of the series'…

  16. 77 FR 74694 - Utility Scale Wind Towers From China and Vietnam; Commission Determination To Deny a Request To...

    Science.gov (United States)

    2012-12-17

    ... From the Federal Register Online via the Government Publishing Office INTERNATIONAL TRADE COMMISSION Utility Scale Wind Towers From China and Vietnam; Commission Determination To Deny a Request To...., Shanghai Taisheng Wind Power Equipment Co., Ltd., the China Chamber of Commerce for Import & Export...

  17. 26 CFR 1.547-5 - Deduction denied in case of fraud or wilful failure to file timely return.

    Science.gov (United States)

    2010-04-01

    ... failure to file timely return. 1.547-5 Section 1.547-5 Internal Revenue INTERNAL REVENUE SERVICE... Companies § 1.547-5 Deduction denied in case of fraud or wilful failure to file timely return. No deduction for deficiency dividends shall be allowed under section 547(a) if the determination contains a finding...

  18. Basic Stand Alone Medicare Hospice Beneficiary PUF

    Data.gov (United States)

    U.S. Department of Health & Human Services — This release contains the Basic Stand Alone (BSA) Hospice Beneficiary Public Use Files (PUF) with information from Medicare hospice claims. The CMS BSA Hospice...

  19. Basic Stand Alone Carrier Line Items PUF

    Data.gov (United States)

    U.S. Department of Health & Human Services — This release contains the Basic Stand Alone (BSA) Carrier Line Items Public Use Files (PUF) with information from Medicare Carrier claims. The CMS BSA Carrier Line...

  20. Basic Stand Alone Medicare Inpatient Claims PUF

    Data.gov (United States)

    U.S. Department of Health & Human Services — This release contains the Basic Stand Alone (BSA) Inpatient Public Use Files (PUF) named CMS 2008 BSA Inpatient Claims PUF with information from 2008 Medicare...

  1. Basic Stand Alone Medicare Outpatient Procedures PUF

    Data.gov (United States)

    U.S. Department of Health & Human Services — This release contains the Basic Stand Alone (BSA) Outpatient Procedures Public Use Files (PUF) with information from Medicare outpatient claims. The CMS BSA...

  2. 试论公共人力资源市场的基本功能%A Thesis on the Basic Function of the Market of Public Human Resources

    Institute of Scientific and Technical Information of China (English)

    李增华

    2012-01-01

    The market of public human resources, which has the essential feature of public service, plays a Key role in the public human resources of socialist market economy. Under the new circumstance, the function of public human resources market can be defined as diversified, comprehensive, multi-channel and multi-level, mainly including storage and feedback function of information, exchange and allocating function of human resource, storage and assembling function of human resource, training and evaluating function of human resource, service and link function of talent recruitment, exploration and promotion function of human resource, socialized service and management function of human resource and guide and ushering function of human resource, etc.%公共人力资源市场是社会主义市场经济中人力资源市场体系的重要组成部分,具有公共服务的本质特征。新形势下,公共人力资源市场的功能是多样的、综合的、多渠道的、多层次的,主要包括信息储存与反馈功能、人力资源交流与调配功能、人力资源储备与聚集功能、人力资源培训与评价功能、人才招聘服务与纽带功能、人力资源开发与促进功能、人力资源社会化服务与管理功能、人力资源业态导向与引领功能等。

  3. Basics of Bayesian Learning - Basically Bayes

    DEFF Research Database (Denmark)

    Larsen, Jan

    Tutorial presented at the IEEE Machine Learning for Signal Processing Workshop 2006, Maynooth, Ireland, September 8, 2006. The tutorial focuses on the basic elements of Bayesian learning and its relation to classical learning paradigms. This includes a critical discussion of the pros and cons....... The theory is illustrated by specific models and examples....

  4. Clinical and pathological features of Denys-Drash syndrome: report of 3 cases%Denys-Drash综合征三例临床病理特点

    Institute of Scientific and Technical Information of China (English)

    王海燕; 孙良忠; 岳智慧; 杨娟; 蒋小云; 莫樱

    2012-01-01

    Objective To study the clinical and pathological features of Denys-Drash syndrome (DDS).Method Three DDS cases who were treated in our department from December 2009 to June 2011 were subjected to this study by reviewing of literature.Result Both case 1 and case 2 were female,with karyotype 46,XX.Case 3 was male with bilateral cryptorchidism.The ages of nephropathy onset of the three cases were 1 year and 9 months,2 years and 8 moths,and 3 months respectively.Proteinuria in case 2 and case 3 were evidenced to be resistant to steroid.Case 1 was partially responsive to tacrolimus,plasma albumin and cholesterol were improved,although proteinuria was persistent after Tacrolimus was administered.Remission was achieved in case 2 after administration of cyclosporine A and later tacrolimus,and her renal function remains normal till present (4 years and 9 months).Residue renal histology revealed diffused mesangial sclerosis (DMS) in all three patients.All of the three patients had developed right unilateral Wilms tumor.A novel WT1 missense mutation exon 9 c.1213C > G was detected in case 1.WT1 exon 9 c.1168C > T nonsense mutation and exon 8 c.1130A > T missense mutation were detected in case 2 and case 3,respectively.Conclusion The clinical manifestation of nephropathy in DDS is variable.The majority present with early onset nephropathy and reach renal failure before the age of 4 years.But in a few patients,nephropathy can also be present much later and progress slowly.Proteinuria in DDS is resistant to steroid but is responsive to calcineurin inhibitors,including Cyclosporine A.The effectiveness of tacrolimus was also observed in this study.DDS is evidently caused by WT1 mutation.DMS is the characteristic renal pathological change in DDS.%目的 探讨Denys-Drash综合征(DDS)的临床病理特征,以加深对DDS的认识.方法 总结2009至2011年诊治3例DDS患儿的临床病理特点和WT1检测结果,并结合文献复习.结果 3例DDS,例1、例2为核型46

  5. Basic digital signal processing

    CERN Document Server

    Lockhart, Gordon B

    1985-01-01

    Basic Digital Signal Processing describes the principles of digital signal processing and experiments with BASIC programs involving the fast Fourier theorem (FFT). The book reviews the fundamentals of the BASIC program, continuous and discrete time signals including analog signals, Fourier analysis, discrete Fourier transform, signal energy, power. The text also explains digital signal processing involving digital filters, linear time-variant systems, discrete time unit impulse, discrete-time convolution, and the alternative structure for second order infinite impulse response (IIR) sections.

  6. Basic molecular spectroscopy

    CERN Document Server

    Gorry, PA

    1985-01-01

    BASIC Molecular Spectroscopy discusses the utilization of the Beginner's All-purpose Symbolic Instruction Code (BASIC) programming language in molecular spectroscopy. The book is comprised of five chapters that provide an introduction to molecular spectroscopy through programs written in BASIC. The coverage of the text includes rotational spectra, vibrational spectra, and Raman and electronic spectra. The book will be of great use to students who are currently taking a course in molecular spectroscopy.

  7. Basic algebraic topology

    CERN Document Server

    Shastri, Anant R

    2013-01-01

    Introduction The Basic Problem Fundamental Group Function Spaces and Quotient Spaces Relative Homotopy Some Typical Constructions Cofibrations Fibrations Categories and Functors Cell Complexes and Simplicial Complexes Basics of Convex Polytopes Cell Complexes Product of Cell Complexes Homotopical Aspects Cellular Maps Abstract Simplicial Complexes Geometric Realization of Simplicial Complexes Barycentric Subdivision Simplicial Approximation Links and Stars Covering Spaces and Fundamental Group Basic Definitions Lifting Properties Relation with the Fundamental Group Classification of Covering P

  8. Basic Research Objectives Reaffirmed

    Institute of Scientific and Technical Information of China (English)

    Guo Haiyan; Zhao Baohua

    2002-01-01

    @@ As a national institution for scientific research and a component of the national innovation system, CAS should and must make key contributions to the great national rejuvenation of the country. Keeping this in mind, CAS has developed four developmental targets for its basic research. This was revealed at a CAS conference on basic research held June 11-12 in Beijing.

  9. Cycles in basic innovations

    NARCIS (Netherlands)

    Groot, de E.A. (Bert); Franses, P.H.P.H.

    2005-01-01

    Basic innovations are often believed to be the drivers of economic growth. It has been widely documented that economic growth follows cyclical patterns of varying length. In this paper we examine if such patterns are also present in basic innovations. For an annual time series of count data covering

  10. Basic principle of superconductivity

    OpenAIRE

    De Cao, Tian

    2007-01-01

    The basic principle of superconductivity is suggested in this paper. There have been two vital wrong suggestions on the basic principle, one is the relation between superconductivity and the Bose-Einstein condensation (BEC), and another is the relation between superconductivity and pseudogap.

  11. Low-Cost MEMS-Based Pedestrian Navigation Technique for GPS-Denied Areas

    Directory of Open Access Journals (Sweden)

    Abdelrahman Ali

    2013-01-01

    Full Text Available The progress in the micro electro mechanical system (MEMS sensors technology in size, cost, weight, and power consumption allows for new research opportunities in the navigation field. Today, most of smartphones, tablets, and other handheld devices are fully packed with the required sensors for any navigation system such as GPS, gyroscope, accelerometer, magnetometer, and pressure sensors. For seamless navigation, the sensors’ signal quality and the sensors availability are major challenges. Heading estimation is a fundamental challenge in the GPS-denied environments; therefore, targeting accurate attitude estimation is considered significant contribution to the overall navigation error. For that end, this research targets an improved pedestrian navigation by developing sensors fusion technique to exploit the gyroscope, magnetometer, and accelerometer data for device attitude estimation in the different environments based on quaternion mechanization. Results indicate that the improvement in the traveled distance and the heading estimations is capable of reducing the overall position error to be less than 15 m in the harsh environments.

  12. Lesbian, gay, and bisexual individuals' psychological reactions to amendments denying access to civil marriage.

    Science.gov (United States)

    Rostosky, Sharon Scales; Riggle, Ellen D B; Horne, Sharon G; Denton, F Nicholas; Huellemeier, Julia Darnell

    2010-07-01

    Political campaigns to deny same-sex couples the right to civil marriage have been demonstrated to increase minority stress and psychological distress in lesbian, gay, and bisexual (LGB) individuals (S. S. Rostosky, E. D. B. Riggle, S. G. Horne, & A. D. Miller, 2009). To further explicate the psychological reactions of LGB individuals to marriage amendment campaigns, a content analysis was conducted of open-ended responses from 300 participants in a national online survey that was conducted immediately following the November 2006 election. LGB individuals indicated that they felt indignant about discrimination; distressed by the negative rhetoric surrounding the campaigns; fearful and anxious about protecting their relationships and families; blaming of institutionalized religion, ignorance, conservative politicians, and the ineffective political strategies used by LGBT organizers; hopeless and resigned; and, finally, hopeful, optimistic, and determined to keep fighting for justice and equal rights. These 7 themes are illustrated and discussed in light of their implications for conceptualizing and intervening to address discrimination and its negative psychological effects.

  13. An unusual presentation of Denys-Drash syndrome due to bigenic disease.

    Science.gov (United States)

    Eneman, Benedicte; Mekahli, Djalila; Audrezet, Marie-Pierre; Lerut, Evelyne; Van Damme-Lombaerts, Rita; Van den Heuvel, Lambertus; Levtchenko, Elena

    2014-01-01

    We report a case of Denys-Drash syndrome (DDS) in a 3-month-old girl presenting with bilateral renal cortical cysts mimicking polycystic kidney disease. Genetic analysis revealed a de novo heterozygous missense mutation c.1186G>A (p.Asp396Asn) in the WT1 gene, confirming the diagnosis of DDS. Because multiple renal cysts have never been reported in DDS, we explored several genes responsible for these renal manifestations, such as HNF-1β, PAX2, PKD1, and PKD2. Remarkably, we identified a heterozygous missense variant c.12439A>G (p.Lys4147Glu) in the PKD1 gene. The same variant was found in the patient's mother, who had no renal cysts, and in the grandfather, who had several renal cysts. Mutation prediction programs classified the c.12439A>G variant as being "likely pathogenic." We hypothesize that the severe cystic phenotype in the index patient could be due to the WT1 mutation, enhancing pathogenicity of the "hypomorph" PKD1 allele. A possible role for Wilms tumor suppressor 1 (WT1) in renal cyst development should be considered. From a conceptual point of view, this case shows that an unusual presentation of a known genetic syndrome might point to bigenic inheritance, with unexpected interference of mutated genes causing an uncommon clinical phenotype.

  14. LiDAR Scan Matching Aided Inertial Navigation System in GNSS-Denied Environments

    Science.gov (United States)

    Tang, Jian; Chen, Yuwei; Niu, Xiaoji; Wang, Li; Chen, Liang; Liu, Jingbin; Shi, Chuang; Hyyppä, Juha

    2015-01-01

    A new scan that matches an aided Inertial Navigation System (INS) with a low-cost LiDAR is proposed as an alternative to GNSS-based navigation systems in GNSS-degraded or -denied environments such as indoor areas, dense forests, or urban canyons. In these areas, INS-based Dead Reckoning (DR) and Simultaneous Localization and Mapping (SLAM) technologies are normally used to estimate positions as separate tools. However, there are critical implementation problems with each standalone system. The drift errors of velocity, position, and heading angles in an INS will accumulate over time, and on-line calibration is a must for sustaining positioning accuracy. SLAM performance is poor in featureless environments where the matching errors can significantly increase. Each standalone positioning method cannot offer a sustainable navigation solution with acceptable accuracy. This paper integrates two complementary technologies—INS and LiDAR SLAM—into one navigation frame with a loosely coupled Extended Kalman Filter (EKF) to use the advantages and overcome the drawbacks of each system to establish a stable long-term navigation process. Static and dynamic field tests were carried out with a self-developed Unmanned Ground Vehicle (UGV) platform—NAVIS. The results prove that the proposed approach can provide positioning accuracy at the centimetre level for long-term operations, even in a featureless indoor environment. PMID:26184206

  15. On pendulums and air resistance. The mathematics and physics of Denis Diderot

    Science.gov (United States)

    Dahmen, Sílvio R.

    2015-09-01

    In this article Denis Diderot's Fifth Memoir of 1748 on the problem of a pendulum damped by air resistance is discussed in its historical as well as mathematical aspects. Diderot wrote the Memoir in order to clarify an assumption Newton made without further justification in the first pages of the Principia in connection with an experiment to verify the Third Law of Motion using colliding pendulums. To explain the differences between experimental and theoretical values, Newton assumed the bob was traversed. By giving Newton's arguments a mathematical scaffolding and recasting his geometrical reasoning in the language of differential calculus, Diderot provided a step-by-step solution guide to the problem. He also showed that Newton's assumption was equivalent to having assumed F R proportional the bob's velocity v, when in fact he believed it should be replaced by F R ˜ v 2. His solution is presented in full detail and his results are compared to those obtained from a Lindstedt-Poincaré approximation for an oscillator with quadratic damping. It is shown that, up to a prefactor, both results coincide. Some results that follow from his approach are presented and discussed for the first time. Experimental evidence to support Diderot's or Newton's claims is discussed together with the limitations of their solutions. Some misprints in the original memoir are pointed out.

  16. Universidad de saint-denis parís 8: polo de desarrollo territorial

    Directory of Open Access Journals (Sweden)

    Iván Segura Lara

    2013-04-01

    Full Text Available El proyecto Universidad, arte y territorio tiene su origen en los archivos fotográficos en torno a laevolución arquitectónica de la universidad de Saint-Denis París-8 que durante 15 años, asociadoa un equipo de investigadores, alimentó el autor, para desarrollar un enfoque transdisciplinarioque analizara el papel de las entidades culturales como motor de las transformaciones territorialeslocales. Se formularon criterios para la creación de laboratorios internacionales de observación delterritorio y análisis de las fuerzas de la globalización que condicionan estas transformaciones. Apartir de esto se infirieron nuevas nociones para definir los criterios de ciudad contemporánea bajolos nuevos paradigmas de la globalización. Simultáneamente, los procesos de documentación yrepresentación construyen a través de su doble especificidad científica y estética un conocimientoy una poesía sensible a los procesos de construcción de la historia de la universidad.

  17. LiDAR Scan Matching Aided Inertial Navigation System in GNSS-Denied Environments.

    Science.gov (United States)

    Tang, Jian; Chen, Yuwei; Niu, Xiaoji; Wang, Li; Chen, Liang; Liu, Jingbin; Shi, Chuang; Hyyppä, Juha

    2015-07-10

    A new scan that matches an aided Inertial Navigation System (INS) with a low-cost LiDAR is proposed as an alternative to GNSS-based navigation systems in GNSS-degraded or -denied environments such as indoor areas, dense forests, or urban canyons. In these areas, INS-based Dead Reckoning (DR) and Simultaneous Localization and Mapping (SLAM) technologies are normally used to estimate positions as separate tools. However, there are critical implementation problems with each standalone system. The drift errors of velocity, position, and heading angles in an INS will accumulate over time, and on-line calibration is a must for sustaining positioning accuracy. SLAM performance is poor in featureless environments where the matching errors can significantly increase. Each standalone positioning method cannot offer a sustainable navigation solution with acceptable accuracy. This paper integrates two complementary technologies-INS and LiDAR SLAM-into one navigation frame with a loosely coupled Extended Kalman Filter (EKF) to use the advantages and overcome the drawbacks of each system to establish a stable long-term navigation process. Static and dynamic field tests were carried out with a self-developed Unmanned Ground Vehicle (UGV) platform-NAVIS. The results prove that the proposed approach can provide positioning accuracy at the centimetre level for long-term operations, even in a featureless indoor environment.

  18. Hurdles in Basic Science Translation

    Directory of Open Access Journals (Sweden)

    Christina J. Perry

    2017-07-01

    Full Text Available In the past century there have been incredible advances in the field of medical research, but what hinders translation of this knowledge into effective treatment for human disease? There is an increasing focus on the failure of many research breakthroughs to be translated through the clinical trial process and into medical practice. In this mini review, we will consider some of the reasons that findings in basic medical research fail to become translated through clinical trials and into basic medical practices. We focus in particular on the way that human disease is modeled, the understanding we have of how our targets behave in vivo, and also some of the issues surrounding reproducibility of basic research findings. We will also look at some of the ways that have been proposed for overcoming these issues. It appears that there needs to be a cultural shift in the way we fund, publish and recognize quality control in scientific research. Although this is a daunting proposition, we hope that with increasing awareness and focus on research translation and the hurdles that impede it, the field of medical research will continue to inform and improve medical practice across the world.

  19. Criminal policy: Basic concepts

    Directory of Open Access Journals (Sweden)

    Jovašević Dragan

    2014-01-01

    Full Text Available In the contemporary literature on law, politicology and security, there have been various attempts in both scientific and applied disciplines to define the notion and content of the crime suppression policy. The differences underlying these diverse views are based on the different starting points, i.e. whether the criminal policy is perceived as: 1] a scientific (academic] discipline; b] a practical daily activity of competent state authorities and other relevant bodies; 3] an activity of combating crime as a set of most dangerous human behaviors which imperil the most important personal assets and social values; and 4] an activity aimed at suppressing all types of illegal behavior (felonies, misdemeanors, delinquency, economic crimes, etc]. Some authors view the policy of crime suppression as a scientific discipline which provides for the appropriate use of existing tools in combating crime. Concurrently, on the basis of defined body of knowledge and analysis, the science (including some sciences outside the field of law] suggests relevant measures for efficient suppression of crime. Another conception is based on the idea that criminal policy has a dual meaning, i.e. that it may be understood as: 1] a practical social activity aimed at accomplishing the envisaged goals (also known as a practical dimension of crime policy], and 2] a scientific discipline which explores, analyses and proposes measures of social reaction towards criminal behavior. In practice, criminal policy encompasses a system of purposeful, consciously planned and coordinated social activities aimed at preventing crime and protecting the society at large. When perceived in this way, criminal policy is the basic element of the general public policy in a specific society. Just like the criminal law of an individual state, criminal policy is based on specific principles (governing rules].

  20. Interplay between Structure and Charge as a Key to Allosteric Modulation of Human 20S Proteasome by the Basic Fragment of HIV-1 Tat Protein.

    Directory of Open Access Journals (Sweden)

    Przemysław Karpowicz

    Full Text Available The proteasome is a giant protease responsible for degradation of the majority of cytosolic proteins. Competitive inhibitors of the proteasome are used against aggressive blood cancers. However, broadening the use of proteasome-targeting drugs requires new mechanistic approaches to the enzyme's inhibition. In our previous studies we described Tat1 peptide, an allosteric inhibitor of the proteasome derived from a fragment of the basic domain of HIV-Tat1 protein. Here, we attempted to dissect the structural determinants of the proteasome inhibition by Tat1. Single- and multiple- alanine walking scans were performed. Tat1 analogs with stabilized beta-turn conformation at positions 4-5 and 8-9, pointed out by the molecular dynamics modeling and the alanine scan, were synthesized. Structure of Tat1 analogs were analyzed by circular dichroism, Fourier transform infrared and nuclear magnetic resonance spectroscopy studies, supplemented by molecular dynamics simulations. Biological activity tests and structural studies revealed that high flexibility and exposed positive charge are hallmarks of Tat1 peptide. Interestingly, stabilization of a beta-turn at the 8-9 position was necessary to significantly improve the inhibitory potency.

  1. Regulating with imagery and the complexity of basic emotions. Comment on "The quartet theory of human emotions: An integrative and neurofunctional model" by S. Koelsch et al.

    Science.gov (United States)

    Meyer, Marcel; Kuchinke, Lars

    2015-06-01

    Literature, music and the arts have long attested to the complexity of human emotions. Hitherto, psychological and biological theories of emotions have largely neglected this rich heritage. In their review Koelsch and colleagues [1] have embarked upon the pioneering endeavour of integrating the diverse perspectives in emotion research. Noting that the focus of prior neurobiological theories relies mainly on animal studies, the authors sought to complement this body of research with a model of complex ("moral") emotions in humans (henceforth: complex emotions). According to this novel framework, there are four main interacting affective centres in the brain. Each centre is associated with a dominant affective function, such as ascending activation (brainstem), pain/pleasure (diencephalon), attachment-related affects (hippocampus) or moral emotions and unconscious cognitive appraisal (orbitofrontal cortex). Furthermore, language is ascribed a key role in (a) the communication of subjective feeling (reconfiguration) and (b) in the conscious regulation of emotions (by means of logic and rational thought).

  2. The Wide-Field DENIS Near-IR Imaging Survey and 6dF Redshift and Peculiar Velocity Surveys

    CERN Document Server

    Mamon, G A

    1998-01-01

    The DENIS survey is currently imaging the entire southern sky in the I, J, and K wavebands. The current star/galaxy separation algorithm is presented and the galaxy counts are nearly perfectly Euclidean. 95% complete and reliable galaxy samples with better than 0.2 magnitude photometry should include 50,000 (K < 12.0), 500,000 (J < 14.8), and 900,000 (I < 16.5) galaxies, respectively, over the full hemisphere. Two spectroscopic followups of DENIS and 2MASS galaxies are planned on the 6dF robotic multi-object spectroscopic unit, currently under construction at the AAO, and which will be mounted on the UKST Schmidt telescope: a redshift survey of roughly 120,000 NIR selected galaxies and a peculiar velocity survey of roughly 15,000 galaxies (both early-types and inclined spirals) at cz < 10,000 km/s.

  3. Quantum electronics basic theory

    CERN Document Server

    Fain, V M; Sanders, J H

    1969-01-01

    Quantum Electronics, Volume 1: Basic Theory is a condensed and generalized description of the many research and rapid progress done on the subject. It is translated from the Russian language. The volume describes the basic theory of quantum electronics, and shows how the concepts and equations followed in quantum electronics arise from the basic principles of theoretical physics. The book then briefly discusses the interaction of an electromagnetic field with matter. The text also covers the quantum theory of relaxation process when a quantum system approaches an equilibrium state, and explai

  4. Basic stress analysis

    CERN Document Server

    Iremonger, M J

    1982-01-01

    BASIC Stress Analysis aims to help students to become proficient at BASIC programming by actually using it in an important engineering subject. It also enables the student to use computing as a means of learning stress analysis because writing a program is analogous to teaching-it is necessary to understand the subject matter. The book begins by introducing the BASIC approach and the concept of stress analysis at first- and second-year undergraduate level. Subsequent chapters contain a summary of relevant theory, worked examples containing computer programs, and a set of problems. Topics c

  5. FCJ-171 Expectations denied: Fan and industry conflict around the localisation of the Japanese video game Yakuza 3

    Directory of Open Access Journals (Sweden)

    Craig Norris

    2014-12-01

    Full Text Available Online fan cultures provides researchers with a space to observe and analyse the development and establishment of fan participation with media properties. The visibility of, and zealous postings by, fans on online forums offers a valuable opportunity to explore what happens when fans feel their expectations are being denied or limited by creator or industry actions. This article examines the fallout around the localisation of the Japanese video game Yakuza 3 into the West in 2010.

  6. A Peer-to-Peer Non-Line-of-Sight Localization System Scheme in GPS-denied Scenarios

    Science.gov (United States)

    2014-09-24

    Under this project, a novel non-line-of-sight (NLOS) localization technique based on the concept of virtual reference device has been developed and...localization in GPS denied scenarios. This is feasible through the use of virtual reference devices. The position of virtual reference device for each...NLOS path can be determined if the initial MD position can be estimated or when the MD transits from LOS to NLOS region. With the position of virtual

  7. Responsiveness to 6-n-propylthiouracil (PROP) is associated with salivary levels of two specific basic proline-rich proteins in humans.

    Science.gov (United States)

    Cabras, Tiziana; Melis, Melania; Castagnola, Massimo; Padiglia, Alessandra; Tepper, Beverly J; Messana, Irene; Tomassini Barbarossa, Iole

    2012-01-01

    Thiourea tasting can be predictive of individual differences in bitter taste responses, general food preferences and eating behavior, and could be correlated with saliva chemical composition. We investigated the possible relationship between PROP bitter taste responsiveness and the salivary proteome in subjects genotyped for TAS2R38 and gustin gene polymorphisms. Taste perception intensity evoked by PROP and NaCl solutions was measured in sixty-three volunteers (21 males, 42 females, age 25±3 y) to establish their PROP taster status, and 24 PROP super-tasters and 21 nontasters were selected to participate in the study. TAS2R38 and gustin gene molecular analysis were performed using PCR techniques. Qualitative and quantitative determination of salivary proteins was performed by HPLC-ESI-MS before and after PROP taste stimulation. PROP super-tastings was strongly associated with the 'taster' variant (PAV haplotype) of TAS2R38 and the A allele of rs2274333 polymorphism in the gustin gene and nontasting was associated with the minor alleles at both loci. ANOVA revealed that basal levels of II-2 and Ps-1 proteins, belonging to the basic proline-rich protein (bPRPs) family, were significantly higher in PROP super-taster than in nontaster un-stimulated saliva, and that PROP stimulation elicited a rapid increase in the levels of these same proteins only in PROP super-taster saliva. These data show for the first time that responsiveness to PROP is associated with salivary levels of II-2 peptide and Ps-1 protein, which are products of the PRB1 gene. These findings suggest that PRB1, in addition to TAS2R38 and gustin, could contribute to individual differences in thiourea sensitivity, and the expression of the PROP phenotype as a complex genetic trait.

  8. Responsiveness to 6-n-propylthiouracil (PROP is associated with salivary levels of two specific basic proline-rich proteins in humans.

    Directory of Open Access Journals (Sweden)

    Tiziana Cabras

    Full Text Available Thiourea tasting can be predictive of individual differences in bitter taste responses, general food preferences and eating behavior, and could be correlated with saliva chemical composition. We investigated the possible relationship between PROP bitter taste responsiveness and the salivary proteome in subjects genotyped for TAS2R38 and gustin gene polymorphisms. Taste perception intensity evoked by PROP and NaCl solutions was measured in sixty-three volunteers (21 males, 42 females, age 25±3 y to establish their PROP taster status, and 24 PROP super-tasters and 21 nontasters were selected to participate in the study. TAS2R38 and gustin gene molecular analysis were performed using PCR techniques. Qualitative and quantitative determination of salivary proteins was performed by HPLC-ESI-MS before and after PROP taste stimulation. PROP super-tastings was strongly associated with the 'taster' variant (PAV haplotype of TAS2R38 and the A allele of rs2274333 polymorphism in the gustin gene and nontasting was associated with the minor alleles at both loci. ANOVA revealed that basal levels of II-2 and Ps-1 proteins, belonging to the basic proline-rich protein (bPRPs family, were significantly higher in PROP super-taster than in nontaster un-stimulated saliva, and that PROP stimulation elicited a rapid increase in the levels of these same proteins only in PROP super-taster saliva. These data show for the first time that responsiveness to PROP is associated with salivary levels of II-2 peptide and Ps-1 protein, which are products of the PRB1 gene. These findings suggest that PRB1, in addition to TAS2R38 and gustin, could contribute to individual differences in thiourea sensitivity, and the expression of the PROP phenotype as a complex genetic trait.

  9. Basic Financial Accounting

    DEFF Research Database (Denmark)

    Wiborg, Karsten

    This textbook on Basic Financial Accounting is targeted students in the economics studies at universities and business colleges having an introductory subject in the external dimension of the company's economic reporting, including bookkeeping, etc. The book includes the following subjects...

  10. HIV Treatment: The Basics

    Science.gov (United States)

    HIV Treatment HIV Treatment: The Basics (Last updated 2/24/2017; last reviewed 2/24/2017) Key Points Antiretroviral therapy (ART) ... reduces the risk of HIV transmission . How do HIV medicines work? HIV attacks and destroys the infection- ...

  11. Opioid Basics: Fentanyl

    Science.gov (United States)

    ... Search Form Controls Cancel Submit Search The CDC Opioid Overdose Note: Javascript is disabled or is not ... message, please visit this page: About CDC.gov . Opioid Overdose Opioid Basics Understanding the Epidemic Commonly Used ...

  12. Physical Activity Basics

    Science.gov (United States)

    ... Weight Breastfeeding Micronutrient Malnutrition State and Local Programs Physical Activity Basics Recommend on Facebook Tweet Share Compartir How much physical activity do you need? Regular physical activity helps improve ...

  13. Kidney Disease Basics

    Science.gov (United States)

    ... Links Take the first step Alternate Language URL Kidney Disease Basics Page Content Your kidneys filter extra ... blood pressure are the most common causes of kidney disease. ​These conditions can slowly damage the kidneys ...

  14. Basic Financial Accounting

    DEFF Research Database (Denmark)

    Wiborg, Karsten

    This textbook on Basic Financial Accounting is targeted students in the economics studies at universities and business colleges having an introductory subject in the external dimension of the company's economic reporting, including bookkeeping, etc. The book includes the following subjects...

  15. Video Screen Capture Basics

    Science.gov (United States)

    Dunbar, Laura

    2014-01-01

    This article is an introduction to video screen capture. Basic information of two software programs, QuickTime for Mac and BlueBerry Flashback Express for PC, are also discussed. Practical applications for video screen capture are given.

  16. Powassan (POW) Virus Basics

    Science.gov (United States)

    ... Professionals Related Topics For International Travelers Powassan (POW) Virus Basics Download this fact sheet formatted for print: ... POW) Virus Fact Sheet (PDF) What is Powassan virus? Powassan (POW) virus is a flavivirus that is ...

  17. The Basic Paradigm of Chinese Traditional Theory of Human Nature and Its Evolution%中国传统人性论的基本范式及其演变

    Institute of Scientific and Technical Information of China (English)

    程欢

    2014-01-01

    Person's stipulation ,human nature ,human nature ,the essence of man ,human nature ,and so on words in different thinkers and scholars have different understanding , there on the definition of the concept should be there and give the different meaning ,they constitute the understanding the essence of human nature , performance ,and contact the words family members ,and the“humanity”words have both sex and simplicity .So you can put to study especially the human basic stipulation and the contact way of learning is called “human nature”.The theory of human nature , since this knowledge to produce , is “flowers, schools of thought con-tend”.So this article in China in different periods ,different thinkers'understanding of human nature and grasp as a benchmark,also discusses the paradigm theory of human nature in different periods ,and the evolution of the theory of human nature have a deeper understanding and the understanding .%人的规定性、人性、人的属性、人的本质、人的本质属性等词语在不同思想家和学者那里有不同的理解,在概念的界定上应该是有差别的并赋予其不同的内涵,他们构成了理解人的本质、表现、本质和联系方式的语词家族的基本成员,而“人性”语词具有统摄性和简单性。因此可以把以人为研究对象尤其是研究人的基本规定性与基本联系方式的学问称为“人性论”。而关于人性的理论,自这一学问产生以来,呈现的是“百花齐放,百家争鸣”的状态。文章以中国不同时期、不同思想家对人性的理解和把握为基准,探讨不同时期人性论的不同范式,从而对人性论的演变有一个更深层次的认识和理解。

  18. Basic Concurrency Theory

    DEFF Research Database (Denmark)

    Løvengreen, Hans Henrik

    2002-01-01

    In this set of notes, we present some of the basic theory underlying the discipline of programming with concurrent processes/threads. The notes are intended to supplement a standard textbook on concurrent programming.......In this set of notes, we present some of the basic theory underlying the discipline of programming with concurrent processes/threads. The notes are intended to supplement a standard textbook on concurrent programming....

  19. Are there basic emotions?

    Science.gov (United States)

    Ekman, P

    1992-07-01

    Ortony and Turner's (1990) arguments against those who adopt the view that there are basic emotions are challenged. The evidence on universals in expression and in physiology strongly suggests that there is a biological basis to the emotions that have been studied. Ortony and Turner's reviews of this literature are faulted, and their alternative theoretical explanations do not fit the evidence. The utility of the basic emotions approach is also shown in terms of the research it has generated.

  20. Correlated-Data Fusion and Cooperative Aiding in GNSS-Stressed or Denied Environments

    Science.gov (United States)

    Mokhtarzadeh, Hamid

    A growing number of applications require continuous and reliable estimates of position, velocity, and orientation. Price requirements alone disqualify most traditional navigation or tactical-grade sensors and thus navigation systems based on automotive or consumer-grade sensors aided by Global Navigation Satellite Systems (GNSS), like the Global Positioning System (GPS), have gained popularity. The heavy reliance on GPS in these navigation systems is a point of concern and has created interest in alternative or back-up navigation systems to enable robust navigation through GPS-denied or stressed environments. This work takes advantage of current trends for increased sensing capabilities coupled with multilayer connectivity to propose a cooperative navigation-based aiding system as a means to limit dead reckoning error growth in the absence of absolute measurements like GPS. Each vehicle carries a dead reckoning navigation system which is aided by relative measurements, like range, to neighboring vehicles together with information sharing. Detailed architectures and concepts of operation are described for three specific applications: commercial aviation, Unmanned Aerial Vehicles (UAVs), and automotive applications. Both centralized and decentralized implementations of cooperative navigation-based aiding systems are described. The centralized system is based on a single Extended Kalman Filter (EKF). A decentralized implementation suited for applications with very limited communication bandwidth is discussed in detail. The presence of unknown correlation between the a priori state and measurement errors makes the standard Kalman filter unsuitable. Two existing estimators for handling this unknown correlation are Covariance Intersection (CI) and Bounded Covariance Inflation (BCInf) filters. A CI-based decentralized estimator suitable for decentralized cooperative navigation implementation is proposed. A unified derivation is presented for the Kalman filter, CI filter

  1. Enabling UAV Navigation with Sensor and Environmental Uncertainty in Cluttered and GPS-Denied Environments.

    Science.gov (United States)

    Vanegas, Fernando; Gonzalez, Felipe

    2016-05-10

    Unmanned Aerial Vehicles (UAV) can navigate with low risk in obstacle-free environments using ground control stations that plan a series of GPS waypoints as a path to follow. This GPS waypoint navigation does however become dangerous in environments where the GPS signal is faulty or is only present in some places and when the airspace is filled with obstacles. UAV navigation then becomes challenging because the UAV uses other sensors, which in turn generate uncertainty about its localisation and motion systems, especially if the UAV is a low cost platform. Additional uncertainty affects the mission when the UAV goal location is only partially known and can only be discovered by exploring and detecting a target. This navigation problem is established in this research as a Partially-Observable Markov Decision Process (POMDP), so as to produce a policy that maps a set of motion commands to belief states and observations. The policy is calculated and updated on-line while flying with a newly-developed system for UAV Uncertainty-Based Navigation (UBNAV), to navigate in cluttered and GPS-denied environments using observations and executing motion commands instead of waypoints. Experimental results in both simulation and real flight tests show that the UAV finds a path on-line to a region where it can explore and detect a target without colliding with obstacles. UBNAV provides a new method and an enabling technology for scientists to implement and test UAV navigation missions with uncertainty where targets must be detected using on-line POMDP in real flight scenarios.

  2. Enabling UAV Navigation with Sensor and Environmental Uncertainty in Cluttered and GPS-Denied Environments

    Directory of Open Access Journals (Sweden)

    Fernando Vanegas

    2016-05-01

    Full Text Available Unmanned Aerial Vehicles (UAV can navigate with low risk in obstacle-free environments using ground control stations that plan a series of GPS waypoints as a path to follow. This GPS waypoint navigation does however become dangerous in environments where the GPS signal is faulty or is only present in some places and when the airspace is filled with obstacles. UAV navigation then becomes challenging because the UAV uses other sensors, which in turn generate uncertainty about its localisation and motion systems, especially if the UAV is a low cost platform. Additional uncertainty affects the mission when the UAV goal location is only partially known and can only be discovered by exploring and detecting a target. This navigation problem is established in this research as a Partially-Observable Markov Decision Process (POMDP, so as to produce a policy that maps a set of motion commands to belief states and observations. The policy is calculated and updated on-line while flying with a newly-developed system for UAV Uncertainty-Based Navigation (UBNAV, to navigate in cluttered and GPS-denied environments using observations and executing motion commands instead of waypoints. Experimental results in both simulation and real flight tests show that the UAV finds a path on-line to a region where it can explore and detect a target without colliding with obstacles. UBNAV provides a new method and an enabling technology for scientists to implement and test UAV navigation missions with uncertainty where targets must be detected using on-line POMDP in real flight scenarios.

  3. 41 CFR 301-10.116 - What must I do with compensation an airline gives me if it denies me a seat on a plane?

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 4 2010-07-01 2010-07-01 false What must I do with compensation an airline gives me if it denies me a seat on a plane? 301-10.116 Section 301-10.116 Public... Fares § 301-10.116 What must I do with compensation an airline gives me if it denies me a seat on a...

  4. Operationalising basic needs: A few fundamental reflections

    OpenAIRE

    Lütkenhorst, Wilfried

    1982-01-01

    Development research (not so much practical development policy-making) has been recently marked by an increased orientation towards the satisfaction of basic needs. This raises the question as to whether indicators exist which could adequately provide for a sufficiently exact operationalisation of at least the basic physical human needs (nutrition, health, shelter, clothing and education). This would enable improved measurement of the degree to which target levels have in fact been reached an...

  5. Human variants in the neuronal basic helix-loop-helix/Per-Arnt-Sim (bHLH/PAS transcription factor complex NPAS4/ARNT2 disrupt function.

    Directory of Open Access Journals (Sweden)

    David C Bersten

    Full Text Available Neuronal Per-Arnt-Sim homology (PAS Factor 4 (NPAS4 is a neuronal activity-dependent transcription factor which heterodimerises with ARNT2 to regulate genes involved in inhibitory synapse formation. NPAS4 functions to maintain excitatory/inhibitory balance in neurons, while mouse models have shown it to play roles in memory formation, social interaction and neurodegeneration. NPAS4 has therefore been implicated in a number of neuropsychiatric or neurodegenerative diseases which are underpinned by defects in excitatory/inhibitory balance. Here we have explored a broad set of non-synonymous human variants in NPAS4 and ARNT2 for disruption of NPAS4 function. We found two variants in NPAS4 (F147S and E257K and two variants in ARNT2 (R46W and R107H which significantly reduced transcriptional activity of the heterodimer on a luciferase reporter gene. Furthermore, we found that NPAS4.F147S was unable to activate expression of the NPAS4 target gene BDNF due to reduced dimerisation with ARNT2. Homology modelling predicts F147 in NPAS4 to lie at the dimer interface, where it appears to directly contribute to protein/protein interaction. We also found that reduced transcriptional activation by ARNT2 R46W was due to disruption of nuclear localisation. These results provide insight into the mechanisms of NPAS4/ARNT dimerisation and transcriptional activation and have potential implications for cognitive phenotypic variation and diseases such as autism, schizophrenia and dementia.

  6. 马斯洛需要层次论在骨科截肢术护理中的应用%The application of maslow's hierarchy of basic human needs theory in the nursing care of the amputated patients

    Institute of Scientific and Technical Information of China (English)

    盘雪梅

    2009-01-01

    Objective To study the effect of Maslow's hierarchy of basic human needs theory applying in the nursing treatment of amputated patients.MethodsNinety eight cases of amputated patients were selected and randomly divided into the study group and control group each contained 49 cases.General nursing cares were performed according to the Maslow's hierarchy of basic human needs theory in the study group,control group carried out routine ones.The patient's psychological situation,the knowledge grasp,degree of satisfaction were valued of the two groups according to the self-rating depressive scale (SDS) ; self-rating anxiety scale (SAS),table of related knowledge master and table of patients satisfactory degree of nursing care.ResultsThe results of general nursing care performed according to the Maslow's hierarchy of basic human needs theory were satisfied.The occurrence rate of the patients'anxiety and despondent were greatly reduced.The degree of satisfactory and knowledge acquirement were distinctly enhanced.ConclusionGeneral nursing care performed according to the Maslow's hierarchy of basic human needs theory on the amputated patients were helpful to patient's psychological adjustment,satisfied patient's right to be known,and improved the service quality.%目的 探讨马斯洛需要层次论在骨科截肢患者护理中的应用效果.方法 选取98例截肢患者随机分为研究组与对照组,每组各49例.研究组参照马斯洛需要层次论施行整体护理;对照组采用常规护理.采用抑郁自评量表(SDS)及焦虑自评量表(SAS)、相关知识掌握情况表、患者对护理工作的满意度表,评价两组患者抑郁、焦虑发生率情况和基本知识掌握情况及患者的满意度.结果 研究组患者的焦虑、抑郁发生率明显低于对照组(P<0.05),研究组患者对护理工作的满意度和知识掌握程度明显高于对照组(P<0.05).结论 应用马斯洛需要层次论对截肢患者施行整体护理,收到

  7. Ligand and electrically induced acitivation patterns in myenteric neuronal networks. Confocal calcium imaging as a bridge between basic and human physiology.

    Science.gov (United States)

    Bisschops, R

    2008-01-01

    Confocal imaging in combination with fluorescent calcium indicators provides the possibility to study neuronal activation in entire neuronal networks. The experiments presented in this essay aimed at applying confocal calcium imaging to study activation patterns in neuronal networks of myenteric ganglia in situ. First we studied the response to electrical train stimulation (ETS). ETS induced Ca2+ transients in 52.2% and 65.4% of the neurons when applied orally and aborally respectively. We observed more responses during aboral ETS which is not in line with the hypothesis of neuronal polarity, suggesting complex neuronal activation patterns and neuronal interaction in ETS-induced activation in myenteric ganglia. We demonstrated that ghrelin has a direct excitatory effect on myenteric neurons in situ via ghrelin receptor activation. Ghrelin induced Ca2+ transients in one third of the myenteric neurons, involving release of Ca2+ from intracellular stores and direct GHS-receptor activation. We found that CRF activates one fifth of the myenteric neurons, via CRF1 receptor activation. These CRF induced Ca2+ signals involved somatic influx through (mainly R-type) voltage operated Ca2+ channels. Finally we set up human studies in healthy volunteers and dyspeptic patients to test the effect of ghrelin on gastrointestinal motility. Intravenous administration of ghrelin induced a premature phase 3 activity front that originated in the stomach and an increase in gastric tone. Ghrelin decreased gastric emptying time for fluids and reduced symptom scores for fullness and pain. These studies provide further evidence for a role of ghrelin in the regulation of gastrointestinal motility, and possibly provide new therapeutic approaches. Our studies show that confocal calcium imaging allows to assess neuronal activation of myenteric neurons. The influence of new hormones or new pharmaceutical compounds on the myenteric plexus can hereby be easily assessed.

  8. Basic Electromagnetism and Materials

    CERN Document Server

    Moliton, André

    2007-01-01

    Basic Electromagnetism and Materials is the product of many years of teaching basic and applied electromagnetism. This textbook can be used to teach electromagnetism to a wide range of undergraduate science majors in physics, electrical engineering or materials science. However, by making lesser demands on mathematical knowledge than competing texts, and by emphasizing electromagnetic properties of materials and their applications, this textbook is uniquely suited to students of materials science. Many competing texts focus on the study of propagation waves either in the microwave or optical domain, whereas Basic Electromagnetism and Materials covers the entire electromagnetic domain and the physical response of materials to these waves. Professor André Moliton is Director of the Unité de Microélectronique, Optoélectronique et Polymères (Université de Limoges, France), which brings together three groups studying the optoelectronics of molecular and polymer layers, micro-optoelectronic systems for teleco...

  9. Nuclear multifragmentation: Basic concepts

    Indian Academy of Sciences (India)

    G Chaudhuri; S Mallik; S Das Gupta

    2014-05-01

    We present a brief overview of nuclear multifragmentation reaction. Basic formalism of canonical thermodynamical model based on equilibrium statistical mechanics is described. This model is used to calculate basic observables of nuclear multifragmentation like mass distribution, fragment multiplicity, isotopic distribution and isoscaling. Extension of canonical thermodynamical model to a projectile fragmentation model is outlined. Application of the projectile fragmentation model for calculating average number of intermediate mass fragments and the average size of the largest cluster at different bound, differential charge distribution and cross-section of neutron-rich nuclei of different projectile fragmentation reactions at different energies are described. Application of nuclear multifragmentation reaction in basic research as well as in other domains is outlined.

  10. Basic properties of semiconductors

    CERN Document Server

    Landsberg, PT

    2013-01-01

    Since Volume 1 was published in 1982, the centres of interest in the basic physics of semiconductors have shifted. Volume 1 was called Band Theory and Transport Properties in the first edition, but the subject has broadened to such an extent that Basic Properties is now a more suitable title. Seven chapters have been rewritten by the original authors. However, twelve chapters are essentially new, with the bulk of this work being devoted to important current topics which give this volume an almost encyclopaedic form. The first three chapters discuss various aspects of modern band theory and the

  11. Basic research championed

    Science.gov (United States)

    Friebele, Elaine

    In April, the Office of National Science and Technology Policy released its biennial report to Congress. Science and Technology: Shaping the Twenty-First Century addresses the President's policy for maintaining U.S. leadership in science and technology, significant developments, and important national issues in science, and opportunities to use science and technology in federal programs and national goals. The administration strongly supports basic research as a sound investment and an inspiration to society. As corporate laboratories increasingly favor applied R&D projects, the federal government is becoming the dominant sponsor of long-term, basic research.

  12. Comprehensive basic mathematics

    CERN Document Server

    Veena, GR

    2005-01-01

    Salient Features As per II PUC Basic Mathematics syllabus of Karnataka. Provides an introduction to various basic mathematical techniques and the situations where these could be usefully employed. The language is simple and the material is self-explanatory with a large number of illustrations. Assists the reader in gaining proficiency to solve diverse variety of problems. A special capsule containing a gist and list of formulae titled ''REMEMBER! Additional chapterwise arranged question bank and 3 model papers in a separate section---''EXAMINATION CORNER''.

  13. Decontamination: back to basics.

    Science.gov (United States)

    Meredith, Susan J; Sjorgen, Geoff

    2008-07-01

    My invitation from this Journal's Editor, Felicia Cox, to provide a paper for this themed issue, included the sentence 'I was wondering if you or a colleague would like to contribute a back to basics article on the relevant standards and guidelines for decontamination, including what is compliance?'. The reason it is so interesting to me is that the term 'back to basics' implies reverting to a simpler time in life - when by just sticking to the rules, life became easier. However, with decontamination this is not actually true.

  14. Basic set theory

    CERN Document Server

    Levy, Azriel

    2002-01-01

    An advanced-level treatment of the basics of set theory, this text offers students a firm foundation, stopping just short of the areas employing model-theoretic methods. Geared toward upper-level undergraduate and graduate students, it consists of two parts: the first covers pure set theory, including the basic motions, order and well-foundedness, cardinal numbers, the ordinals, and the axiom of choice and some of it consequences; the second deals with applications and advanced topics such as point set topology, real spaces, Boolean algebras, and infinite combinatorics and large cardinals. An

  15. Basic Financial Accounting

    DEFF Research Database (Denmark)

    Wiborg, Karsten

    This textbook on Basic Financial Accounting is targeted students in the economics studies at universities and business colleges having an introductory subject in the external dimension of the company's economic reporting, including bookkeeping, etc. The book includes the following subjects: busin......: business entities, the transformation process, types of businesses, stakeholders, legislation, the annual report, the VAT system, double-entry bookkeeping, inventories, and year-end cast flow analysis.......This textbook on Basic Financial Accounting is targeted students in the economics studies at universities and business colleges having an introductory subject in the external dimension of the company's economic reporting, including bookkeeping, etc. The book includes the following subjects...

  16. Basic Library List.

    Science.gov (United States)

    Duren, William L., Jr.

    Reported is an initial attempt to define a minimal college mathematics library. Included is a list of some 300 books, from which approximately 170 are to be chosen to form a basic library in undergraduate mathematics. The areas provided for in this list include Algebra, Analysis, Applied Mathematics, Geometry, Topology, Logic, Foundations and Set…

  17. Lippincott Basic Reading Program.

    Science.gov (United States)

    Monterey Peninsula Unified School District, Monterey, CA.

    This program, included in "Effective Reading Programs...," serves 459 students in grades 1-3 at 15 elementary schools. The program employs a diagnostic-prescriptive approach to instruction in a nongraded setting through the use of the Lippincott Basic Reading program. When a child enters the program, he is introduced to a decoding…

  18. Canadian Adult Basic Education.

    Science.gov (United States)

    Brooke, W. Michael, Comp.

    "Trends," a publication of the Canadian Association for Adult Education, is a collection of abstracts on selected subjects affecting adult education; this issue is on adult basic education (ABE). It covers teachers and teacher training, psychological factors relating to the ABE teacher and students, manuals for teachers, instructional…

  19. Basic Drafting: Book Two.

    Science.gov (United States)

    Davis, Ronald; And Others

    The second of a two-book course in drafting, this manual consists of 12 topics in the following units: sketching techniques, geometric constructions, orthographic views, dimensioning procedures, basic tolerancing, auxiliary views, sectional views, inking tools and techniques, axonometrics, oblique, perspective, and computer-aided drafting.…

  20. Basic Microfluidics Theory

    DEFF Research Database (Denmark)

    Svendsen, Winnie Edith

    2015-01-01

    ,000 m−1, which is a huge difference and has a large impact on flow behavior. In this chapter the basic microfluidic theory will be presented, enabling the reader to gain a comprehensive understanding of how liquids behave at the microscale, enough to be able to engage in design of micro systems...

  1. Assessing Basic Fact Fluency

    Science.gov (United States)

    Kling, Gina; Bay-Williams, Jennifer M.

    2014-01-01

    In this article, the authors share a variety of ways to formatively assess basic fact fluency. The define fluency, raise some issues related to timed testing, and then share a collection of classroom-tested ideas for authentic fact fluency assessment. This article encourages teachers to try a variety of alternative assessments from this sampling,…

  2. Basic Nuclear Physics.

    Science.gov (United States)

    Bureau of Naval Personnel, Washington, DC.

    Basic concepts of nuclear structures, radiation, nuclear reactions, and health physics are presented in this text, prepared for naval officers. Applications to the area of nuclear power are described in connection with pressurized water reactors, experimental boiling water reactors, homogeneous reactor experiments, and experimental breeder…

  3. Basic SPSS tutorial

    NARCIS (Netherlands)

    Grotenhuis, H.F. te; Matthijssen, A.C.B.

    2015-01-01

    This supplementary book for the social, behavioral, and health sciences helps readers with no prior knowledge of IBM® SPSS® Statistics, statistics, or mathematics learn the basics of SPSS. Designed to reduce fear and build confidence, the book guides readers through point-and-click sequences using

  4. Korean Basic Course.

    Science.gov (United States)

    Defense Language Inst., Washington, DC.

    These 11 volumes of the Korean Basic Course comprise 112 lesson units designed to train native English language speakers to Level 3 proficiency in comprehension and speaking and Level 2 proficiency in reading and writing Korean. (Level 5 on this scale is native-speaker level.) Intended for classroom use in the Defense Language Institute intensive…

  5. Ethanol Basics (Fact Sheet)

    Energy Technology Data Exchange (ETDEWEB)

    2015-01-01

    Ethanol is a widely-used, domestically-produced renewable fuel made from corn and other plant materials. More than 96% of gasoline sold in the United States contains ethanol. Learn more about this alternative fuel in the Ethanol Basics Fact Sheet, produced by the U.S. Department of Energy's Clean Cities program.

  6. Basic bioreactor design.

    NARCIS (Netherlands)

    Riet, van 't K.; Tramper, J.

    1991-01-01

    Based on a graduate course in biochemical engineering, provides the basic knowledge needed for the efficient design of bioreactors and the relevant principles and data for practical process engineering, with an emphasis on enzyme reactors and aerated reactors for microorganisms. Includes exercises.

  7. Basic physics for all

    CERN Document Server

    Kumar, B N

    2012-01-01

    This is a simple, concise book for both student and non-physics students, presenting basic facts in straightforward form and conveying fundamental principles and theories of physics. This book will be helpful as a supplement to class teaching and to aid those who have difficulty in mastering concepts and principles.

  8. Turkish Basic Course.

    Science.gov (United States)

    Defense Language Inst., Washington, DC.

    These 14 volumes of the Defense Language Institute's basic course in Turkish consist of 112 lesson units designed to train native English language speakers to Level 3 proficiency in comprehending, speaking, reading, and writing Turkish. (Native-speaker fluency is Level 5.) An introduction to the sound system, vowel harmony, and syllable division…

  9. Basic bioreactor design.

    NARCIS (Netherlands)

    Riet, van 't K.; Tramper, J.

    1991-01-01

    Based on a graduate course in biochemical engineering, provides the basic knowledge needed for the efficient design of bioreactors and the relevant principles and data for practical process engineering, with an emphasis on enzyme reactors and aerated reactors for microorganisms. Includes exercises.

  10. FULA BASIC COURSE.

    Science.gov (United States)

    SWIFT, LLOYD B.; AND OTHERS

    THIS BEGINNING COURSE IS AN INTRODUCTION TO FULA (KNOWN VARIOUSLY AS FULANI, FUL, PEUL, OR PHEUL), A NIGER-CONGO LANGUAGE SPOKEN THROUGHOUT THE GRASSLAND AREAS OF WEST AFRICA FROM THE ATLANTIC TO CAMEROUN. THE TEXT IS ONE OF A SERIES OF SHORT BASIC COURSES IN SELECTED AFRICAN LANGUAGES BEING PREPARED BY THE FOREIGN SERVICE INSTITUTE. IT IS…

  11. Basic Tuberculosis Facts

    Centers for Disease Control (CDC) Podcasts

    2012-03-12

    In this podcast, Dr. Kenneth Castro, Director of the Division of Tuberculosis Elimination, discusses basic TB prevention, testing, and treatment information.  Created: 3/12/2012 by National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention (NCHHSTP).   Date Released: 3/12/2012.

  12. HPLC-ESI-MS and MS/MS structural characterization of multifucosylated N-glycoforms of the basic proline-rich protein IB-8a CON1+ in human saliva.

    Science.gov (United States)

    Cabras, Tiziana; Boi, Roberto; Pisano, Elisabetta; Iavarone, Federica; Fanali, Chiara; Nemolato, Sonia; Faa, Gavino; Castagnola, Massimo; Messana, Irene

    2012-05-01

    This study describes the characterization of the glycan moieties and the peptide backbone of six glycoforms of IB-8a CON1(+), a basic proline-rich protein present in human saliva. MS analyses on the intact glycoproteins before and after N-deglycosylation with PNGase F and high-resolution MS/MS sequencing by LTQ Orbitrap XL of peptides and glycopeptides from tryptic digests allowed the structural characterization of the glycan moieties and the polypeptide backbone, as well as to establish the glycosylation site at the asparagine residue at 98th position. Five of the glycoforms carry a biantennary N-linked glycan fucosylated in the innermost N-acetylglucosamine of the core and showing from zero to four additional fucoses in the antennal region. The sixth glycoform carries a monoantennary monofucosylated oligosaccharide. The glycoform cluster was detected on 28 of 71 adult saliva specimens. Level of fucosylation showed interindividual variability with the major relative abundance for the trifucosylated glycoform. Nonglycosylated IB-8a CON1(+) and the variant IB-8a CON1(-), lacking of the glycosylation site, have been also detected in human saliva.

  13. FERC denies rehearing on rule allowing automatic qualifying status to new diesel and dual-fuel cogeneration facilities

    Energy Technology Data Exchange (ETDEWEB)

    1984-09-01

    The Federal Energy Regulatory Commission (FERC) denied Consolidated Edison's request for a rehearing on the 1981 rule which automatically qualifies new diesel and dual-fueled cogeneration facilities under sections 201 and 210 of the Public Utility Regulatory Policies Act. The petition was to return these two types of facilities on an interim exlusion status because of deficiencies in final environmental impact statements, faulty projections of the growth of cogeneration, socio-economic impacts, and tax effects. The article presents the arguments on both sides and FERC's conclusions.

  14. bFGF在人胚胎干细胞中自我更新的研究进展%Roles of basic fibroblast growth factor in the seft-renewal of human embryonic stem cells

    Institute of Scientific and Technical Information of China (English)

    王延伟; 李建远

    2009-01-01

    The self-renewal and multi-lineage developmental potential are the unique properties of human embryonic stem(ES) cells. The growth factors that maintain human or mouse embryonic stem cells are different. Leuckemia inhibitory factor(LIF) does not maintain self-renewal of human ES cells(hESCs). Recently, a few growth factors have been found to be biologically relevant for hESCs functions in vitro, among them the basic fibroblast growth factor(bFGF) is one of the most significant regulators of hESCs self-renewal. The purpose of this review is to introduce the recent progress in the research on the expressions of bFGF and its receptors and their functions in hESCs.%人胚胎干细胞具有自我更新和多向分化的独特生物学特性.维持人和小鼠胚胎干细胞增殖的生长因子不同,白血病抑制因子(UF)不能维持人胚胎干细胞的生长.目前已经确定了数种维持人胚胎干细胞(hESCs)自我更新的生长因子.其中碱性成纤维细胞生长因子(bFGF)信号系统是人胚胎干细胞自我更新中最重要的调节因素之一.将从bFGF及其受体在人胚胎干细胞中的表达和作用的最新进展进行综述.

  15. Basics of statistical physics

    CERN Document Server

    Müller-Kirsten, Harald J W

    2013-01-01

    Statistics links microscopic and macroscopic phenomena, and requires for this reason a large number of microscopic elements like atoms. The results are values of maximum probability or of averaging. This introduction to statistical physics concentrates on the basic principles, and attempts to explain these in simple terms supplemented by numerous examples. These basic principles include the difference between classical and quantum statistics, a priori probabilities as related to degeneracies, the vital aspect of indistinguishability as compared with distinguishability in classical physics, the differences between conserved and non-conserved elements, the different ways of counting arrangements in the three statistics (Maxwell-Boltzmann, Fermi-Dirac, Bose-Einstein), the difference between maximization of the number of arrangements of elements, and averaging in the Darwin-Fowler method. Significant applications to solids, radiation and electrons in metals are treated in separate chapters, as well as Bose-Eins...

  16. Basic plasma physics

    CERN Document Server

    Ghosh, Basudev

    2014-01-01

    Basic Plasma Physics is designed to serve as an introductory compact textbook for advanced undergraduate, postgraduate and research students taking plasma physics as one of their subject of study for the first time. It covers the current syllabus of plasma physics offered by the most universities and technical institutions. The book requires no background in plasma physics but only elementary knowledge of basic physics and mathematics. Emphasis has been given on the analytical approach. Topics are developed from first principle so that the students can learn through self-study. One chapter has been devoted to describe some practical aspects of plasma physics. Each chapter contains a good number of solved and unsolved problems and a variety of review questions, mostly taken from recent examination papers. Some classroom experiments described in the book will surely help students as well as instructors.

  17. Basics of RF electronics

    CERN Document Server

    Gallo, A

    2011-01-01

    RF electronics deals with the generation, acquisition and manipulation of high-frequency signals. In particle accelerators signals of this kind are abundant, especially in the RF and beam diagnostics systems. In modern machines the complexity of the electronics assemblies dedicated to RF manipulation, beam diagnostics, and feedbacks is continuously increasing, following the demands for improvement of accelerator performance. However, these systems, and in particular their front-ends and back-ends, still rely on well-established basic hardware components and techniques, while down-converted and acquired signals are digitally processed exploiting the rapidly growing computational capability offered by the available technology. This lecture reviews the operational principles of the basic building blocks used for the treatment of high-frequency signals. Devices such as mixers, phase and amplitude detectors, modulators, filters, switches, directional couplers, oscillators, amplifiers, attenuators, and others are d...

  18. Emulsion Science Basic Principles

    CERN Document Server

    Leal-Calderon, Fernando; Schmitt, Véronique

    2007-01-01

    Emulsions are generally made out of two immiscible fluids like oil and water, one being dispersed in the second in the presence of surface-active compounds.They are used as intermediate or end products in a huge range of areas including the food, chemical, cosmetic, pharmaceutical, paint, and coating industries. Besides the broad domain of technological interest, emulsions are raising a variety of fundamental questions at the frontier between physics and chemistry. This book aims to give an overview of the most recent advances in emulsion science. The basic principles, covering aspects of emulsions from their preparation to their destruction, are presented in close relation to both the fundamental physics and the applications of these materials. The book is intended to help scientists and engineers in formulating new materials by giving them the basics of emulsion science.

  19. Basic linear algebra

    CERN Document Server

    Blyth, T S

    2002-01-01

    Basic Linear Algebra is a text for first year students leading from concrete examples to abstract theorems, via tutorial-type exercises. More exercises (of the kind a student may expect in examination papers) are grouped at the end of each section. The book covers the most important basics of any first course on linear algebra, explaining the algebra of matrices with applications to analytic geometry, systems of linear equations, difference equations and complex numbers. Linear equations are treated via Hermite normal forms which provides a successful and concrete explanation of the notion of linear independence. Another important highlight is the connection between linear mappings and matrices leading to the change of basis theorem which opens the door to the notion of similarity. This new and revised edition features additional exercises and coverage of Cramer's rule (omitted from the first edition). However, it is the new, extra chapter on computer assistance that will be of particular interest to readers:...

  20. Basic electronic circuits

    CERN Document Server

    Buckley, P M

    1980-01-01

    In the past, the teaching of electricity and electronics has more often than not been carried out from a theoretical and often highly academic standpoint. Fundamentals and basic concepts have often been presented with no indication of their practical appli­ cations, and all too frequently they have been illustrated by artificially contrived laboratory experiments bearing little relationship to the outside world. The course comes in the form of fourteen fairly open-ended constructional experiments or projects. Each experiment has associated with it a construction exercise and an explanation. The basic idea behind this dual presentation is that the student can embark on each circuit following only the briefest possible instructions and that an open-ended approach is thereby not prejudiced by an initial lengthy encounter with the theory behind the project; this being a sure way to dampen enthusiasm at the outset. As the investigation progresses, questions inevitably arise. Descriptions of the phenomena encounte...

  1. Basic Semiconductor Physics

    CERN Document Server

    Hamaguchi, Chihiro

    2010-01-01

    This book presents a detailed description of the basic semiconductor physics. The reader is assumed to have a basic command of mathematics and some elementary knowledge of solid state physics. The text covers a wide range of important phenomena in semiconductors, from the simple to the advanced. The reader can understand three different methods of energy band calculations, empirical pseudo-potential, k.p perturbation and tight-binding methods. The effective mass approximation and electron motion in a periodic potential, Boltzmann transport equation and deformation potentials used for full band Monte Carlo simulation are discussed. Experiments and theoretical analysis of cyclotron resonance are discussed in detail because the results are essential to the understanding of semiconductor physics. Optical and transport properties, magneto-transport, two dimensional electron gas transport (HEMT and MOSFET), and quantum transport are reviewed, explaining optical transition, electron phonon interactions, electron mob...

  2. Basic ergodic theory

    CERN Document Server

    Nadkarni, M G

    2013-01-01

    This is an introductory book on Ergodic Theory. The presentation has a slow pace and the book can be read by any person with a background in basic measure theory and metric topology. A new feature of the book is that the basic topics of Ergodic Theory such as the Poincare recurrence lemma, induced automorphisms and Kakutani towers, compressibility and E. Hopf's theorem, the theorem of Ambrose on representation of flows are treated at the descriptive set-theoretic level before their measure-theoretic or topological versions are presented. In addition, topics around the Glimm-Effros theorem are discussed. In the third edition a chapter entitled 'Additional Topics' has been added. It gives Liouville's Theorem on the existence of invariant measure, entropy theory leading up to Kolmogorov-Sinai Theorem, and the topological dynamics proof of van der Waerden's theorem on arithmetical progressions.

  3. Visual Basic educational programme

    OpenAIRE

    Pranaitis, Arūnas

    2005-01-01

    Visual basic educational programme Informational Technologies has become such a popular subject that they are applied in all works of life. However, Informational Technologies are still rarely used in the lessons at school. There are such reasons of the mentioned issue: · Insufficient base of computers, · The old software and its disadvantages, · The lack of computerized educational programmes. The aim of the work was to prove that it is actual to create computerized educat...

  4. Basics of Computer Networking

    CERN Document Server

    Robertazzi, Thomas

    2012-01-01

    Springer Brief Basics of Computer Networking provides a non-mathematical introduction to the world of networks. This book covers both technology for wired and wireless networks. Coverage includes transmission media, local area networks, wide area networks, and network security. Written in a very accessible style for the interested layman by the author of a widely used textbook with many years of experience explaining concepts to the beginner.

  5. Menstrual Cycle: Basic Biology

    OpenAIRE

    2008-01-01

    The basic biology of the menstrual cycle is a complex, coordinated sequence of events involving the hypothalamus, anterior pituitary, ovary, and endometrium. The menstrual cycle with all its complexities can be easily perturbed by environmental factors such as stress, extreme exercise, eating disorders, and obesity. Furthermore, genetic influences such as fragile X premutations (Chapter X), X chromosome abnormalities (Chapter X), and galactose-1-phosphate uridyltransferase (GALT) point mutati...

  6. Risk communication basics

    Energy Technology Data Exchange (ETDEWEB)

    Corrado, P.G. [Lawrence Livermore National Laboratory, CA (United States)

    1995-12-31

    In low-trust, high-concern situations, 50% of your credibility comes from perceived empathy and caring, demonstrated in the first 30 s you come in contact with someone. There is no second chance for a first impression. These and other principles contained in this paper provide you with a basic level of understanding of risk communication. The principles identified are time-tested caveats and will assist you in effectively communicating technical information.

  7. Basic Financial Accounting

    DEFF Research Database (Denmark)

    Wiborg, Karsten

    This textbook on Basic Financial Accounting is targeted students in the economics studies at universities and business colleges having an introductory subject in the external dimension of the company's economic reporting, including bookkeeping, etc. The book includes the following subjects......: business entities, the transformation process, types of businesses, stakeholders, legislation, the annual report, the VAT system, double-entry bookkeeping, inventories, and year-end cast flow analysis....

  8. Thermodynamics - basic conception

    Energy Technology Data Exchange (ETDEWEB)

    Wee, Eul Bok

    1979-08-15

    This book tells of basic conception of thermodynamics, condition and property of matter, work and power, thermal efficiency, the principle of the conservation of energy, relationship between work and heat, enthalpy, Jouel's law, complete gasification, the second low of thermodynamics such as thermal efficiency and quality factor, carnot cycle, and entropy, condensation of gas like press of internal combustion engine, vapor, steam power plant and structure, internal combustion cycle, freeze cycle, flow of fluid, combustion and heat transfer.

  9. Decision support basics

    CERN Document Server

    Power, Daniel J

    2009-01-01

    This book is targeted to busy managers and MBA students who need to grasp the basics of computerized decision support. Some of the topics covered include: What is a DSS? What do managers need to know about computerized decision support? And how can managers identify opportunities to create innovative DSS? Overall the book addresses 35 fundamental questions that are relevant to understanding computerized decision support.

  10. The basic anaesthesia machine.

    Science.gov (United States)

    Gurudatt, Cl

    2013-09-01

    After WTG Morton's first public demonstration in 1846 of use of ether as an anaesthetic agent, for many years anaesthesiologists did not require a machine to deliver anaesthesia to the patients. After the introduction of oxygen and nitrous oxide in the form of compressed gases in cylinders, there was a necessity for mounting these cylinders on a metal frame. This stimulated many people to attempt to construct the anaesthesia machine. HEG Boyle in the year 1917 modified the Gwathmey's machine and this became popular as Boyle anaesthesia machine. Though a lot of changes have been made for the original Boyle machine still the basic structure remains the same. All the subsequent changes which have been brought are mainly to improve the safety of the patients. Knowing the details of the basic machine will make the trainee to understand the additional improvements. It is also important for every practicing anaesthesiologist to have a thorough knowledge of the basic anaesthesia machine for safe conduct of anaesthesia.

  11. The basic anaesthesia machine

    Directory of Open Access Journals (Sweden)

    C L Gurudatt

    2013-01-01

    Full Text Available After WTG Morton′s first public demonstration in 1846 of use of ether as an anaesthetic agent, for many years anaesthesiologists did not require a machine to deliver anaesthesia to the patients. After the introduction of oxygen and nitrous oxide in the form of compressed gases in cylinders, there was a necessity for mounting these cylinders on a metal frame. This stimulated many people to attempt to construct the anaesthesia machine. HEG Boyle in the year 1917 modified the Gwathmey′s machine and this became popular as Boyle anaesthesia machine. Though a lot of changes have been made for the original Boyle machine still the basic structure remains the same. All the subsequent changes which have been brought are mainly to improve the safety of the patients. Knowing the details of the basic machine will make the trainee to understand the additional improvements. It is also important for every practicing anaesthesiologist to have a thorough knowledge of the basic anaesthesia machine for safe conduct of anaesthesia.

  12. Value Formation of Basic Anthropological Connectivities

    DEFF Research Database (Denmark)

    Bertelsen, Preben

    2009-01-01

    and their political value formations. In this regard, the interdisciplinary contribution of Psychology is to explore how humans as active participants can and will participate in handling such value tasks. The article presents a general, theoretical, political-psychological model, which unites precisely these two...... aspects: The political value formations of the basic anthropological conditions in human life, and the capability and will to participate in solving the subsequent value tasks....

  13. Denys-Drash syndrome associated WT1 glutamine 369 mutants have altered sequence-preferences and altered responses to epigenetic modifications

    Energy Technology Data Exchange (ETDEWEB)

    Hashimoto, Hideharu; Zhang, Xing; Zheng, Yu; Wilson, Geoffrey G.; Cheng, Xiaodong

    2016-09-04

    Mutations in human zinc-finger transcription factor WT1 result in abnormal development of the kidneys and genitalia and an array of pediatric problems including nephropathy, blastoma, gonadal dysgenesis and genital discordance. Several overlapping phenotypes are associated with WT1 mutations, including Wilms tumors, Denys-Drash syndrome (DDS), Frasier syndrome (FS) and WAGR syndrome (Wilms tumor, aniridia, genitourinary malformations, and mental retardation). These conditions vary in severity from individual to individual; they can be fatal in early childhood, or relatively benign into adulthood. DDS mutations cluster predominantly in zinc fingers (ZF) 2 and 3 at the C-terminus of WT1, which together with ZF4 determine the sequence-specificity of DNA binding. We examined three DDS associated mutations in ZF2 of human WT1 where the normal glutamine at position 369 is replaced by arginine (Q369R), lysine (Q369K) or histidine (Q369H). These mutations alter the sequence-specificity of ZF2, we find, changing its affinity for certain bases and certain epigenetic forms of cytosine. X-ray crystallography of the DNA binding domains of normal WT1, Q369R and Q369H in complex with preferred sequences revealed the molecular interactions responsible for these affinity changes. DDS is inherited in an autosomal dominant fashion, implying a gain of function by mutant WT1 proteins. This gain, we speculate, might derive from the ability of the mutant proteins to sequester WT1 into unproductive oligomers, or to erroneously bind to variant target sequences.

  14. [Obstetric and neonatal outcomes of adolescent pregnancies: a cohort study in a hospital in Seine-Saint-Denis France].

    Science.gov (United States)

    Debras, E; Revaux, A; Bricou, A; Laas, E; Tigaizin, A; Benbara, A; Carbillon, L

    2014-09-01

    The aim of this study was to describe the characteristics, monitoring, obstetrical complications, childbirth and neonatal outcomes of pregnancies among minors in a cohort of adolescents from Seine-Saint-Denis (France). This is a retrospective, cohort, comparative study, conducted from January 1, 1996 to July 31, 2011, made from the database of Jean-Verdier hospital in Seine-Saint-Denis. Three groups were established: patients aged less than 16 years old, patients aged over 16 years old and under 18 years old compared to a group consisting of older primiparas from 18 to 25 years old. The criteria considered were the characteristics of pregnancy, terms of delivery, neonatal outcome and conduct of post-partum. Minor patients were statistically more likely to be single, student, smoking and anemia compared to young adults. The obstetrical care was lower for minor compared to the control group with a number of consultations and ultrasounds lower (P Adolescentes under 16 years old had a higher preterm delivery risk in multivariate analysis (RR = 0.33 CI 95% [0.12; 0.90] P = 0.03). Adolescents had fewer cesarean and instrumental deliveries (P < 0.05). Teenage pregnancy remains an important managing issue for maternities, particularly from a social standpoint. On the medical side, one preterm delivery appears to be more common among these adolescents. Copyright © 2014 Elsevier Masson SAS. All rights reserved.

  15. Barbecue Basics: Tips to Prevent Foodborne Illness

    Medline Plus

    Full Text Available ... common links HHS U.S. Department of Health and Human Services U.S. Food and Drug Administration A to ... in FDA’s Center for Food Safety and Applied Nutrition. Wash hands. It seems basic, but not everyone ...

  16. Basic Education and Policy Support (BEPS) Activity.

    Science.gov (United States)

    Creative Associates International, Inc., Washington, DC.

    The Basic Education and Policy Support (BEPS) Activity is a multi-year, worldwide, indefinite quantity contract by which the U.S. Agency for International Development (USAID) Global Bureau Center for Human Capacity (G/HCD) can work to achieve four objectives: (1) improve the quality, efficiency, access, and equity of education, particularly basic…

  17. Digital storytelling teaching robotics basics

    Directory of Open Access Journals (Sweden)

    Michele Scandola

    2013-01-01

    Full Text Available Digital Storytelling (DST is a powerful tool for teaching complex concepts. DSTs are typically used in the humanities but several papers have shown that they are also a wonderful tool for the sciences because they are more involving, contextualized and can easily lead to deeper understanding. In the classical use of DST the story is thecontent, while the digital medium is the way of telling it. Our approach is slightly different: the story is not the content but a glue for the main contents, while the digital medium remains the way to tell the story. We propose the use of DST as a means to teach surgeons the basics of robotic surgery, by using a story that should be involving forthem, i.e. a surgical operation, within which we will illustrate specific concepts onrobotics in surgery.

  18. [Basic concepts about paternity testing].

    Science.gov (United States)

    Lagos, Marcela; Poggi, Helena; Mellado, Cecilia

    2011-04-01

    Nowadays, the analysis of genetic markers is a very important and validated tool for the identification of individuals, and for paternity testing. To do so, highly variable regions of the human genome are analyzed, making it possible to obtain the genetic profile of an individual, and to distinguish between different individuals. The methodology used is basically the same all over the world, consisting in the analysis of 13 to 15 markers. To assign biological paternity the child must have inherited the characteristics from the alleged father in each of the genetic markers analyzed. This analysis achieves a certainty higher than with any other test, which is expressed as the probability of paternity. This probability has to be at least 99.9%, but greater probabilities are usually obtained, especially if the mother is included in the analysis. If the characteristics of two or more genetic markers from the alleged father are absent in the child, biological paternity is excluded.

  19. Catalyst in Basic Oleochemicals

    Directory of Open Access Journals (Sweden)

    Eva Suyenty

    2007-10-01

    Full Text Available Currently Indonesia is the world largest palm oil producer with production volume reaching 16 million tones per annum. The high crude oil and ethylene prices in the last 3 – 4 years contribute to the healthy demand growth for basic oleochemicals: fatty acids and fatty alcohols. Oleochemicals are starting to replace crude oil derived products in various applications. As widely practiced in petrochemical industry, catalyst plays a very important role in the production of basic oleochemicals. Catalytic reactions are abound in the production of oleochemicals: Nickel based catalysts are used in the hydrogenation of unsaturated fatty acids; sodium methylate catalyst in the transesterification of triglycerides; sulfonic based polystyrene resin catalyst in esterification of fatty acids; and copper chromite/copper zinc catalyst in the high pressure hydrogenation of methyl esters or fatty acids to produce fatty alcohols. To maintain long catalyst life, it is crucial to ensure the absence of catalyst poisons and inhibitors in the feed. The preparation methods of nickel and copper chromite catalysts are as follows: precipitation, filtration, drying, and calcinations. Sodium methylate is derived from direct reaction of sodium metal and methanol under inert gas. The sulfonic based polystyrene resin is derived from sulfonation of polystyrene crosslinked with di-vinyl-benzene. © 2007 BCREC UNDIP. All rights reserved.[Presented at Symposium and Congress of MKICS 2007, 18-19 April 2007, Semarang, Indonesia][How to Cite: E. Suyenty, H. Sentosa, M. Agustine, S. Anwar, A. Lie, E. Sutanto. (2007. Catalyst in Basic Oleochemicals. Bulletin of Chemical Reaction Engineering and Catalysis, 2 (2-3: 22-31.  doi:10.9767/bcrec.2.2-3.6.22-31][How to Link/DOI: http://dx.doi.org/10.9767/bcrec.2.2-3.6.22-31 || or local: http://ejournal.undip.ac.id/index.php/bcrec/article/view/6

  20. C# Database Basics

    CERN Document Server

    Schmalz, Michael

    2012-01-01

    Working with data and databases in C# certainly can be daunting if you're coming from VB6, VBA, or Access. With this hands-on guide, you'll shorten the learning curve considerably as you master accessing, adding, updating, and deleting data with C#-basic skills you need if you intend to program with this language. No previous knowledge of C# is necessary. By following the examples in this book, you'll learn how to tackle several database tasks in C#, such as working with SQL Server, building data entry forms, and using data in a web service. The book's code samples will help you get started

  1. Back to basics audio

    CERN Document Server

    Nathan, Julian

    1998-01-01

    Back to Basics Audio is a thorough, yet approachable handbook on audio electronics theory and equipment. The first part of the book discusses electrical and audio principles. Those principles form a basis for understanding the operation of equipment and systems, covered in the second section. Finally, the author addresses planning and installation of a home audio system.Julian Nathan joined the audio service and manufacturing industry in 1954 and moved into motion picture engineering and production in 1960. He installed and operated recording theaters in Sydney, Austra

  2. Basic heat transfer

    CERN Document Server

    Bacon, D H

    2013-01-01

    Basic Heat Transfer aims to help readers use a computer to solve heat transfer problems and to promote greater understanding by changing data values and observing the effects, which are necessary in design and optimization calculations.The book is concerned with applications including insulation and heating in buildings and pipes, temperature distributions in solids for steady state and transient conditions, the determination of surface heat transfer coefficients for convection in various situations, radiation heat transfer in grey body problems, the use of finned surfaces, and simple heat exc

  3. Machine shop basics

    CERN Document Server

    Miller, Rex

    2004-01-01

    Use the right tool the right wayHere, fully updated to include new machines and electronic/digital controls, is the ultimate guide to basic machine shop equipment and how to use it. Whether you're a professional machinist, an apprentice, a trade student, or a handy homeowner, this fully illustrated volume helps you define tools and use them properly and safely. It's packed with review questions for students, and loaded with answers you need on the job.Mark Richard Miller is a Professor and Chairman of the Industrial Technology Department at Texas A&M University in Kingsville, T

  4. Electrical installation calculations basic

    CERN Document Server

    Kitcher, Christopher

    2013-01-01

    All the essential calculations required for basic electrical installation workThe Electrical Installation Calculations series has proved an invaluable reference for over forty years, for both apprentices and professional electrical installation engineers alike. The book provides a step-by-step guide to the successful application of electrical installation calculations required in day-to-day electrical engineering practice. A step-by-step guide to everyday calculations used on the job An essential aid to the City & Guilds certificates at Levels 2 and 3Fo

  5. Basic genetics for dermatologists

    Directory of Open Access Journals (Sweden)

    Muthu Sendhil Kumaran

    2013-01-01

    Full Text Available During the past few decades, advances in the field of molecular genetics have enriched us in understanding the pathogenesis of diseases, their identification, and appropriate therapeutic interventions. In the last 20 years, genetic basis of more than 350 monogenic skin diseases have been elucidated and is counting. The widespread use of molecular genetics as a tool in diagnosis is not practiced routinely due to genetic heterogenicity, limited access and low sensitivity. In this review, we have presented the very basics of genetics so as to enable dermatologists to have working understanding of medical genetics.

  6. Basic structural dynamics

    CERN Document Server

    Anderson, James C

    2012-01-01

    A concise introduction to structural dynamics and earthquake engineering Basic Structural Dynamics serves as a fundamental introduction to the topic of structural dynamics. Covering single and multiple-degree-of-freedom systems while providing an introduction to earthquake engineering, the book keeps the coverage succinct and on topic at a level that is appropriate for undergraduate and graduate students. Through dozens of worked examples based on actual structures, it also introduces readers to MATLAB, a powerful software for solving both simple and complex structural d

  7. Effect of CPU-XT-008, a combretastatin A-4 analogue, on the proliferation, apoptosis and expression of vascular endothelial growth factor and basic fibroblast growth factor in human umbilical vein endothelial cells.

    Science.gov (United States)

    Xiong, Rui; Sun, Jing; Liu, Kun; Xu, Yungen; He, Shuying

    2016-01-01

    The present study investigated the effect of the combretastatin A-4 analogue CPU-XT-008 on the proliferation, apoptosis and expression of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (FGF-2) in human umbilical vein endothelial cells (HUVECs). The proliferation capacity of HUVECs was analyzed with a cell viability assay, while their apoptosis and migration abilities were evaluated via flow cytometry and monolayer denudation assay, respectively. The mRNA and protein expression levels of VEGF and FGF-2 in these cells were determined by reverse transcription-polymerase chain reaction, and cell-based ELISA, western blotting and immunocytochemistry, respectively. The results demonstrated that CPU-XT-008 inhibited proliferation and migration, and induced apoptosis in HUVECs in a dose-dependent manner. In addition, CPU-XT-008 downregulated the mRNA and protein expression levels of VEGF and FGF-2 in these cells. These findings suggest that CPU-XT-008 exerts anti-angiogenic effects in HUVECs, which may explain the inhibition of cell proliferation and migration, induction of apoptosis, and reduction in the mRNA and protein expression levels of VEGF and FGF-2 observed in the present study.

  8. Denis Parsons Burkitt CMG, MD, DSc, FRS, FRCS, FTCD (1911-93) Irish by birth, Trinity by the grace of God.

    Science.gov (United States)

    Smith, Owen

    2012-03-01

    Denis Parsons Burkitt, surgeon and research scientist, is a household name in the medical profession. Denis received his BA in 1933 and graduated as a physician in 1935 from Trinity College, Dublin. After serving as a surgeon in the Royal Army Medicine Corps during World War II, he worked as a surgeon and lecturer in Africa. It was in Africa that he developed exceptional observational and analytical skills, which led him to identify and formally develop a successful treatment for a childhood cancer that is now called Burkitt Lymphoma. The influence of Christianity in his life was huge. Throughout his life he remained extremely modest, attributing much of what he had achieved to the work of others. Denis's contributions to haemato-oncology remain salient today, and his discoveries continue to generate new research. Throughout his career he received some of the highest scientific honours from many different countries across the globe.

  9. Basic research projects

    Energy Technology Data Exchange (ETDEWEB)

    1979-04-01

    The research programs under the cognizance of the Office of Energy Research (OER) are directed toward discovery of natural laws and new knowledge, and to improved understanding of the physical and biological sciences as related to the development, use, and control of energy. The ultimate goal is to develop a scientific underlay for the overall DOE effort and the fundamental principles of natural phenomena so that these phenomena may be understood, and new principles, formulated. The DOE-OER outlay activities include three major programs: High Energy Physics, Nuclear Physics, and Basic Energy Sciences. Taken together, these programs represent some 30 percent of the Nation's Federal support of basic research in the energy sciences. The research activities of OER involve more than 6,000 scientists and engineers working in some 17 major Federal Research Centers and at more than 135 different universities and industrial firms throughout the United States. Contract holders in the areas of high-energy physics, nuclear physics, materials sciences, nuclear science, chemical sciences, engineering, mathematics geosciences, advanced energy projects, and biological energy research are listed. Funding trends for recent years are outlined. (RWR)

  10. Basic Ozone Layer Science

    Science.gov (United States)

    Learn about the ozone layer and how human activities deplete it. This page provides information on the chemical processes that lead to ozone layer depletion, and scientists' efforts to understand them.

  11. Stem Cell Basics

    Science.gov (United States)

    ... why are they important? Stem cells have the remarkable potential to develop into many different cell types ... of Health, U.S. Department of Health and Human Services, 2016 [cited October 9, 2017 ] Available at < //stemcells. ...

  12. Unaccompanied & Denied: Regional Legal Framework for Unaccompanied Minors Asylum Seekers (UMAS

    Directory of Open Access Journals (Sweden)

    Rohaida Nordin

    2015-12-01

    Full Text Available Unaccompanied minor asylum seekers are vulnerable and thus, provided special international law protections. However, in reality, they are being mistreated as illegal immigrants and on thereceiving end of ethnic violence, discrimination, restrictions in enjoyment of their rights duly recognised by international human rights law. This article identifies legislative, policy and supportmechanisms which encompass the minimum UMAS guardianship standards at international law and which are evidence-based from best practice models for the provision of guardians for UMASinternationally. It presents situation of UMAS in relation to human rights violations with emphasis on the legal framework and practices in Australia and five ASEAN State Members. This article also highlights the various stands taken by various countries providing better legal framework and practices regarding the terms for protection and enforcement of human rights for UMAS. Finally, this article provides recommendations for Australia and ASEAN Member States to adopt in order to realise the international human rights of UMAS with respect to guardianship.

  13. p-[{sup 123}I]iodo-l-phenylalanine for detection of pancreatic cancer: basic investigations of the uptake characteristics in primary human pancreatic tumour cells and evaluation in in vivo models of human pancreatic adenocarcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Samnick, Samuel; Hellwig, Dirk; Kirsch, Carl-Martin [Department of Nuclear Medicine, Saarland University Medical Center, 66421, Homburg/Saar (Germany); Romeike, Bernd F.M.; Feiden, Wolfgang [Department of Neuropathology, Saarland University Medical Center, Homburg/Saar (Germany); Kubuschok, Boris [Department of Internal Medicine I, Saarland University Medical Center, Homburg/Saar (Germany); Amon, Michaela; Menger, Michael D. [Department of Clinical Experimental Surgery, Saarland University Medical Center, Homburg/Saar (Germany)

    2004-04-01

    Pancreatic cancer is associated with the worst 5-year survival rate of any human cancer. This high mortality is due, in part, to difficulties in establishing early and accurate diagnosis. Because most tumours share the ability to accumulate amino acids more effectively than normal tissues and any other pathology, assessment of amino acid transport in tumour cells using radiolabelled amino acids has become one of the most promising tools for tumour imaging. This study investigated the potential of p-[{sup 123}I]iodo-l-phenylalanine (IPA) for detection of pancreatic cancer by single-photon emission tomography. IPA affinity for pancreatic tumour was investigated in human pancreatic adenocarcinoma PaCa44 and PanC1 cells, followed by analysis of the underlying mechanisms of tracer accumulation in neoplastic cells. Thereafter, IPA was evaluated for targeting of pancreatic tumours using SCID mice engrafted with primary human pancreatic adenocarcinoma cells, as well as in acute inflammation models in immunocompetent mice and rats. IPA accumulated intensively in human pancreatic tumour cells. Radioactivity accumulation in tumour cells following a 30-min incubation at 37 C/pH 7.4 varied from 41% to 58% of the total loaded activity per 10{sup 6} cells. The cellular uptake was temperature and pH dependent and predominantly mediated by specific carriers for neutral amino acids, namely the sodium-independent and l-leucine-preferring (L-system) transporter and the alanine-, serine- and cysteine-preferring (ASC-system) transporter. Protein incorporation was less than 8%. Biodistribution studies showed rapid localization of the tracer to tumours, reaching 10%{+-}2.5% to 15%{+-}3% of the injected dose per gram (I.D./g) in heterotopic tumours compared with 17%{+-}3.5% to 22%{+-}4.3% I.D./g in the orthotopic tumours, at 60 and 240 min post injection of IPA, respectively. In contrast, IPA uptake in the gastrointestinal tract and areas of inflammation remained moderate and decreased

  14. The Performance of a Tight Ins/gnss/photogrammetric Integration Scheme for Land Based MMS Applications in Gnss Denied Environments

    Science.gov (United States)

    Chu, Chien-Hsun; Chiang, Kai-Wei

    2016-06-01

    The early development of mobile mapping system (MMS) was restricted to applications that permitted the determination of the elements of exterior orientation from existing ground control. Mobile mapping refers to a means of collecting geospatial data using mapping sensors that are mounted on a mobile platform. Research works concerning mobile mapping dates back to the late 1980s. This process is mainly driven by the need for highway infrastructure mapping and transportation corridor inventories. In the early nineties, advances in satellite and inertial technology made it possible to think about mobile mapping in a different way. Instead of using ground control points as references for orienting the images in space, the trajectory and attitude of the imager platform could now be determined directly. Cameras, along with navigation and positioning sensors are integrated and mounted on a land vehicle for mapping purposes. Objects of interest can be directly measured and mapped from images that have been georeferenced using navigation and positioning sensors. Direct georeferencing (DG) is the determination of time-variable position and orientation parameters for a mobile digital imager. The most common technologies used for this purpose today are satellite positioning using the Global Navigation Satellite System (GNSS) and inertial navigation using an Inertial Measuring Unit (IMU). Although either technology used along could in principle determine both position and orientation, they are usually integrated in such a way that the IMU is the main orientation sensor, while the GNSS receiver is the main position sensor. However, GNSS signals are obstructed due to limited number of visible satellites in GNSS denied environments such as urban canyon, foliage, tunnel and indoor that cause the GNSS gap or interfered by reflected signals that cause abnormal measurement residuals thus deteriorates the positioning accuracy in GNSS denied environments. This study aims at developing a

  15. THE PERFORMANCE OF A TIGHT INS/GNSS/PHOTOGRAMMETRIC INTEGRATION SCHEME FOR LAND BASED MMS APPLICATIONS IN GNSS DENIED ENVIRONMENTS

    Directory of Open Access Journals (Sweden)

    C.-H. Chu

    2016-06-01

    Full Text Available The early development of mobile mapping system (MMS was restricted to applications that permitted the determination of the elements of exterior orientation from existing ground control. Mobile mapping refers to a means of collecting geospatial data using mapping sensors that are mounted on a mobile platform. Research works concerning mobile mapping dates back to the late 1980s. This process is mainly driven by the need for highway infrastructure mapping and transportation corridor inventories. In the early nineties, advances in satellite and inertial technology made it possible to think about mobile mapping in a different way. Instead of using ground control points as references for orienting the images in space, the trajectory and attitude of the imager platform could now be determined directly. Cameras, along with navigation and positioning sensors are integrated and mounted on a land vehicle for mapping purposes. Objects of interest can be directly measured and mapped from images that have been georeferenced using navigation and positioning sensors. Direct georeferencing (DG is the determination of time-variable position and orientation parameters for a mobile digital imager. The most common technologies used for this purpose today are satellite positioning using the Global Navigation Satellite System (GNSS and inertial navigation using an Inertial Measuring Unit (IMU. Although either technology used along could in principle determine both position and orientation, they are usually integrated in such a way that the IMU is the main orientation sensor, while the GNSS receiver is the main position sensor. However, GNSS signals are obstructed due to limited number of visible satellites in GNSS denied environments such as urban canyon, foliage, tunnel and indoor that cause the GNSS gap or interfered by reflected signals that cause abnormal measurement residuals thus deteriorates the positioning accuracy in GNSS denied environments. This study aims

  16. Atomic Basic Blocks

    Science.gov (United States)

    Scheler, Fabian; Mitzlaff, Martin; Schröder-Preikschat, Wolfgang

    Die Entscheidung, einen zeit- bzw. ereignisgesteuerten Ansatz für ein Echtzeitsystem zu verwenden, ist schwierig und sehr weitreichend. Weitreichend vor allem deshalb, weil diese beiden Ansätze mit äußerst unterschiedlichen Kontrollflussabstraktionen verknüpft sind, die eine spätere Migration zum anderen Paradigma sehr schwer oder gar unmöglich machen. Wir schlagen daher die Verwendung einer Zwischendarstellung vor, die unabhängig von der jeweils verwendeten Kontrollflussabstraktion ist. Für diesen Zweck verwenden wir auf Basisblöcken basierende Atomic Basic Blocks (ABB) und bauen darauf ein Werkzeug, den Real-Time Systems Compiler (RTSC) auf, der die Migration zwischen zeit- und ereignisgesteuerten Systemen unterstützt.

  17. Basics of plasma astrophysics

    CERN Document Server

    Chiuderi, Claudio

    2015-01-01

    This book is an introduction to contemporary plasma physics that discusses the most relevant recent advances in the field and covers a careful choice of applications to various branches of astrophysics and space science. The purpose of the book is to allow the student to master the basic concepts of plasma physics and to bring him or her up to date in a number of relevant areas of current research. Topics covered include orbit theory, kinetic theory, fluid models, magnetohydrodynamics, MHD turbulence, instabilities, discontinuities, and magnetic reconnection. Some prior knowledge of classical physics is required, in particular fluid mechanics, statistical physics, and electrodynamics. The mathematical developments are self-contained and explicitly detailed in the text. A number of exercises are provided at the end of each chapter, together with suggestions and solutions.

  18. Anisotropic hydrodynamics -- basic concepts

    CERN Document Server

    Florkowski, Wojciech; Ryblewski, Radoslaw; Strickland, Michael

    2013-01-01

    Due to the rapid longitudinal expansion of the quark-gluon plasma created in relativistic heavy ion collisions, potentially large local rest frame momentum-space anisotropies are generated. The magnitude of these momentum-space anisotropies can be so large as to violate the central assumption of canonical viscous hydrodynamical treatments which linearize around an isotropic background. In order to better describe the early-time dynamics of the quark gluon plasma, one can consider instead expanding around a locally anisotropic background which results in a dynamical framework called anisotropic hydrodynamics. In this proceedings contribution we review the basic concepts of the anisotropic hydrodynamics framework presenting viewpoints from both the phenomenological and microscopic points of view.

  19. Cloud computing basics

    CERN Document Server

    Srinivasan, S

    2014-01-01

    Cloud Computing Basics covers the main aspects of this fast moving technology so that both practitioners and students will be able to understand cloud computing. The author highlights the key aspects of this technology that a potential user might want to investigate before deciding to adopt this service. This book explains how cloud services can be used to augment existing services such as storage, backup and recovery. Addressing the details on how cloud security works and what the users must be prepared for when they move their data to the cloud. Also this book discusses how businesses could prepare for compliance with the laws as well as industry standards such as the Payment Card Industry.

  20. Basic real analysis

    CERN Document Server

    Sohrab, Houshang H

    2014-01-01

    This expanded second edition presents the fundamentals and touchstone results of real analysis in full rigor, but in a style that requires little prior familiarity with proofs or mathematical language. The text is a comprehensive and largely self-contained introduction to the theory of real-valued functions of a real variable. The chapters on Lebesgue measure and integral have been rewritten entirely and greatly improved. They now contain Lebesgue’s differentiation theorem as well as his versions of the Fundamental Theorem(s) of Calculus. With expanded chapters, additional problems, and an expansive solutions manual, Basic Real Analysis, Second Edition, is ideal for senior undergraduates and first-year graduate students, both as a classroom text and a self-study guide. Reviews of first edition: The book is a clear and well-structured introduction to real analysis aimed at senior undergraduate and beginning graduate students. The prerequisites are few, but a certain mathematical sophistication is required. ....

  1. Basic engineering mathematics

    CERN Document Server

    Bird, John

    2014-01-01

    Introductory mathematics written specifically for students new to engineering Now in its sixth edition, Basic Engineering Mathematics is an established textbook that has helped thousands of students to succeed in their exams. John Bird's approach is based on worked examples and interactive problems. This makes it ideal for students from a wide range of academic backgrounds as the student can work through the material at their own pace. Mathematical theories are explained in a straightforward manner, being supported by practical engineering examples and applications in order to ensure that readers can relate theory to practice. The extensive and thorough topic coverage makes this an ideal text for introductory level engineering courses. This title is supported by a companion website with resources for both students and lecturers, including lists of essential formulae, multiple choice tests, full solutions for all 1,600 further questions contained within the practice exercises, and biographical information on t...

  2. Magnetism basics and applications

    CERN Document Server

    Stefanita, Carmen-Gabriela

    2012-01-01

    This textbook is aimed at engineering students who are likely to come across magnetics applications in their professional practice. Whether designing lithography equipment containing ferromagnetic brushes, or detecting defects in aeronautics, some basic knowledge of 21st century magnetism is needed. From the magnetic tape on the pocket credit card to the read head in a personal computer, people run into magnetism in many products. Furthermore, in a variety of disciplines tools of the trade exploit magnetic principles, and many interdisciplinary laboratory research areas cross paths with magnetic phenomena that may seem mysterious to the untrained mind. Therefore, this course offers a broad coverage of magnetism topics encountered more often in this millenium, revealing key concepts on which many practical applications rest. Some traditional subjects in magnetism are discussed in the first half of the book, followed by areas likely to spark the curiosity of those more interested in today’s technological achi...

  3. Denis Billote, Le vocabulaire de la traduction par Jean de Meun de la Consolatio philosophiae de Boèce

    OpenAIRE

    Bertrand, Olivier

    2008-01-01

    L’ouvrage de Denis Billotte suscite l’intérêt pour deux raisons principales. La première concerne exclusivement les procédés de «translation» au Moyen Âge à partir d’un ouvrage-source écrit en latin au VIe siècle, la Consolatio Philosophiae de Boèce, et de sa traduction en langue vernaculaire au XIIIe siècle par Jean de Meun. Les deux lexiques exhaustifs français-latin et latin-français permettent de comprendre très facilement les enjeux des équivalences lexicales et montrent bien la manière ...

  4. A Ground-Based Near Infrared Camera Array System for UAV Auto-Landing in GPS-Denied Environment

    Directory of Open Access Journals (Sweden)

    Tao Yang

    2016-08-01

    Full Text Available This paper proposes a novel infrared camera array guidance system with capability to track and provide real time position and speed of a fixed-wing Unmanned air vehicle (UAV during a landing process. The system mainly include three novel parts: (1 Infrared camera array and near infrared laser lamp based cooperative long range optical imaging module; (2 Large scale outdoor camera array calibration module; and (3 Laser marker detection and 3D tracking module. Extensive automatic landing experiments with fixed-wing flight demonstrate that our infrared camera array system has the unique ability to guide the UAV landing safely and accurately in real time. Moreover, the measurement and control distance of our system is more than 1000 m. The experimental results also demonstrate that our system can be used for UAV automatic accurate landing in Global Position System (GPS-denied environments.

  5. European grapevine moth (Lobesia botrana Denis and Schiff. (Lepidoptera: Totricidae – occurence and management in Istrian vineyards

    Directory of Open Access Journals (Sweden)

    Renata Bažok

    2016-02-01

    Full Text Available The aim of this paper was to identify European grapevine moths (Lobesia botrana Denis and Schiff. flight dynamics, larvae occurrence and degree-day accumulations (DDA for each moth generation in two Istrian vineyards with different pest management practices. The moth has developed three generations. During the third generation there was a significant flight peak in the vineyard without pest management. Predictions about larvae number and possible damage must be based on both, visual monitoring of grapevine and weekly adults catch. Developmental time with lower thermal threshold of 7 °C was calculated. The flight of the first generation was between 217.9 and 406.6 °C, second generation between 786.3 and 1329.8 °C, third generation between 1452.8 and 2108.2 °C.

  6. A Ground-Based Near Infrared Camera Array System for UAV Auto-Landing in GPS-Denied Environment.

    Science.gov (United States)

    Yang, Tao; Li, Guangpo; Li, Jing; Zhang, Yanning; Zhang, Xiaoqiang; Zhang, Zhuoyue; Li, Zhi

    2016-08-30

    This paper proposes a novel infrared camera array guidance system with capability to track and provide real time position and speed of a fixed-wing Unmanned air vehicle (UAV) during a landing process. The system mainly include three novel parts: (1) Infrared camera array and near infrared laser lamp based cooperative long range optical imaging module; (2) Large scale outdoor camera array calibration module; and (3) Laser marker detection and 3D tracking module. Extensive automatic landing experiments with fixed-wing flight demonstrate that our infrared camera array system has the unique ability to guide the UAV landing safely and accurately in real time. Moreover, the measurement and control distance of our system is more than 1000 m. The experimental results also demonstrate that our system can be used for UAV automatic accurate landing in Global Position System (GPS)-denied environments.

  7. A Ground-Based Near Infrared Camera Array System for UAV Auto-Landing in GPS-Denied Environment

    Science.gov (United States)

    Yang, Tao; Li, Guangpo; Li, Jing; Zhang, Yanning; Zhang, Xiaoqiang; Zhang, Zhuoyue; Li, Zhi

    2016-01-01

    This paper proposes a novel infrared camera array guidance system with capability to track and provide real time position and speed of a fixed-wing Unmanned air vehicle (UAV) during a landing process. The system mainly include three novel parts: (1) Infrared camera array and near infrared laser lamp based cooperative long range optical imaging module; (2) Large scale outdoor camera array calibration module; and (3) Laser marker detection and 3D tracking module. Extensive automatic landing experiments with fixed-wing flight demonstrate that our infrared camera array system has the unique ability to guide the UAV landing safely and accurately in real time. Moreover, the measurement and control distance of our system is more than 1000 m. The experimental results also demonstrate that our system can be used for UAV automatic accurate landing in Global Position System (GPS)-denied environments. PMID:27589755

  8. Clinical Trial Basics

    Science.gov (United States)

    ... How Am I Protected? Mark Bowden / iStock Ethical guidelines The goal of clinical research is to develop knowledge that improves human ... data and decide whether the results have medical importance. Results from clinical trials are often published in peer-reviewed scientific ...

  9. 77 FR 54402 - Dichlorvos (DDVP); Order Denying NRDC's Objections on Remand

    Science.gov (United States)

    2012-09-05

    ... and distribution networks that constrain concentration and flux of metabolic reactants.'' (Ref. 19 at... protection of infants and children. Further, because Benchmark Dose Methods analysis is discussed for the... internal dose for humans. This is due to species differences in general metabolic...

  10. S1 subsite specificity of a recombinant cysteine proteinase, CPB, of Leishmania mexicana compared with cruzain, human cathepsin L and papain using substrates containing non-natural basic amino acids.

    Science.gov (United States)

    Alves, L C; Melo, R L; Sanderson, S J; Mottram, J C; Coombs, G H; Caliendo, G; Santagada, V; Juliano, L; Juliano, M A

    2001-03-01

    We have explored the substrate specificity of a recombinant cysteine proteinase of Leishmania mexicana (CPB2.8 Delta CTE) in order to obtain data that will enable us to design specific inhibitors of the enzyme. Previously we have shown that the enzyme has high activity towards substrates with a basic group at the P1 position [Hilaire, P.M.S., Alves, L.C., Sanderson, S.J., Mottram, J.C., Juliano, M.A., Juliano, L., Coombs, G.H. & Meldal M. (2000) Chem. Biochem. 1, 115--122], but we have also observed high affinity for peptides with hydrophobic residues at this position. In order to have substrates containing both features, we synthesized one series of internally quenched fluorogenic peptides derived from the sequence ortho-amino-benzoyl-FRSRQ-N-[2,4-dinitrophenyl]-ethylenediamine, and substituted the Arg at the P1 position with the following non-natural basic amino acids: 4-aminomethyl-phenylalanine (Amf), 4-guanidine-phenylalanine (Gnf), 4-aminomethyl-N-isopropyl-phenylalanine (Iaf), 3-pyridyl-alanine (Pya), 4-piperidinyl-alanine (Ppa), 4-aminomethyl-cyclohexyl-alanine (Ama), and 4-aminocyclohexyl-alanine (Aca). For comparison, the series derived from ortho-amino-benzoyl-FRSRQ-N-[2,4-dinitrophenyl]-ethylenediamine was also assayed with cruzain (the major cysteine proteinase of Trypanosoma cruzi), human cathepsin L and papain. The peptides ortho-amino-benzoyl-FAmfSRQ-N-[2,4-dinitrophenyl]-ethylenediamine (k(cat)/K(m) = 12,000 mM(-1) x s(-1)) and ortho-amino-benzoyl-FIafSRQ-N-[2,4-dinitrophenyl]-ethylenediamine (k(cat)/K(m) = 27,000 mM(-1) x s(-1)) were the best substrates for CPB2.8 Delta CTE. In contrast, ortho-amino-benzoyl-FAmaSRQ-N-[2,4-dinitrophenyl]-ethylenediamine and ortho-amino-benzoyl-FAcaSRQ-N-[2,4-dinitrophenyl]-ethylenediamine were very resistant and inhibited this enzyme with K(i) values of 23 nM and 30 nM, respectively. Cruzain hydrolyzed quite well the substrates in this series with Amf, Ppa and Aca, whereas the peptide with Ama was resistant and

  11. 作为基本权的劳动权之本位价值:人的自我实现%Fundamental Values of Labor Rights as the Basic Rights : Human Self - realization

    Institute of Scientific and Technical Information of China (English)

    袁立

    2011-01-01

    Labor rights are no longer limited to survival value in the physics significance, self- realization value rising to fundamental value. Self - realization is file results caused by system power of individual and the national behavior in the pluralistie society, including two factors: "self realization" and "self-development". Labor Rights is the integration of self- realization and the constitution order; is a kind of basic right of social country, whose essence attributes to self - realization. Protection of labor rights and human self - realization must be aided by construction of function of formulization of labor rights, promotes self - determination by the objective value order of labor rights, and protects the self - development by the subjective right attribute of labor rights.%劳动权不再局限于物理意义的生存价值,自我实现价值上升为本位价值。自我实现是多元社会中个人和国家行为联动力的结果,包括“自我决定”和“自我开展”两个要素。劳动权是自我实现和宪法秩序的整合规范,是一种社会国基本权利,其本质归结干人的自我实现。从宪法规范演进看,自我实现始终作为劳动权的显性价值而存在。劳动权保障和人的自我实现,需借助于劳动权功能构建,以劳动权的客观价值秩序促进自我决定,以劳动权的主观权利属性保障自我开展。

  12. The porcine ear skin as a model system for the human integument: influence of storage conditions on basic features of epidermis structure and function--a histological and histochemical study.

    Science.gov (United States)

    Meyer, W; Zschemisch, N H; Godynicki, S

    2003-01-01

    Based on careful tissue processing, detailed structural analysis, and histochemical as well as cytophotometrical evaluation of the epidermis, the study presents data with respect to changes of tissue integrity during two storing modes (room temperature and 4 degrees C) and various storage times of the porcine auricle. Structural degeneration was first noted in the barrier region of the epidermis from where such changes spread, independent of storage conditions, from small horizontal necrotic islands and continuously with increasing storage time. The histochemical results corroborated these observations, emphasizing, however, that the lower epidermal layers seemed intact for a longer time period than the upper layers. Cytophotometrical evaluation of histochemical stainings showed, with regard to the enzyme succinate dehydrogenase, that oxidative metabolism was negatively affected in the early stages of storage, whereas epidermal lipids (neutral fats, glycolipids) remained relatively stable, even during storage at room temperature. In conclusion, it was obvious that the barrier region is the most sensitive element of the porcine ear epidermis. Taking into consideration that this part of the epidermis is most important for permeation studies, it seems reasonable to avoid any storage of porcine auricles at room temperature, and to use only auricles that have been stored at 4 degrees C for not more than 4 to 6 hours, immediately after delivery from the slaughter-house. In this way better tissue preservation can be achieved, whereby the use of shinkage-free water-soluble plastic embedding would generally improve the histological control of structural integrity, and the application of an easy to handle enzyme histochemical procedure (e.g. succinate dehydrogenase demonstration) to unfixed fresh-frozen sections would help to control basic aspects of tissue functions. The results are discussed in relation to the use of porcine integument as a model in human dermatological

  13. Basics of cytology

    Science.gov (United States)

    Al-Abbadi, Mousa A.

    2011-01-01

    This overview is intended to give a general outline about the basics of Cytopathology. This is a field that is gaining tremendous momentum all over the world due to its speed, accuracy and cost effectiveness. This review will include a brief description about the history of cytology from its inception followed by recent developments. Discussion about the different types of specimens, whether exfoliative or aspiration will be presented with explanation of its rule as a screening and diagnostic test. A brief description of the indications, utilization, sensitivity, specificity, cost effectiveness, speed and accuracy will be carried out. The role that cytopathology plays in early detection of cancer will be emphasized. The ability to provide all types of ancillary studies necessary to make specific diagnosis that will dictate treatment protocols will be demonstrated. A brief description of the general rules of cytomorphology differentiating benign from malignant will be presented. Emphasis on communication between clinicians and pathologist will be underscored. The limitations and potential problems in the form of false positive and false negative will be briefly discussed. Few representative examples will be shown. A brief description of the different techniques in performing fine needle aspirations will be presented. General recommendation for the safest methods and hints to enhance the sensitivity of different sample procurement will be given. It is hoped that this review will benefit all practicing clinicians that may face certain diagnostic challenges requiring the use of cytological material. PMID:23210005

  14. Basic operator theory

    CERN Document Server

    Gohberg, Israel

    2001-01-01

    rii application of linear operators on a Hilbert space. We begin with a chapter on the geometry of Hilbert space and then proceed to the spectral theory of compact self adjoint operators; operational calculus is next presented as a nat­ ural outgrowth of the spectral theory. The second part of the text concentrates on Banach spaces and linear operators acting on these spaces. It includes, for example, the three 'basic principles of linear analysis and the Riesz­ Fredholm theory of compact operators. Both parts contain plenty of applications. All chapters deal exclusively with linear problems, except for the last chapter which is an introduction to the theory of nonlinear operators. In addition to the standard topics in functional anal­ ysis, we have presented relatively recent results which appear, for example, in Chapter VII. In general, in writ­ ing this book, the authors were strongly influenced by re­ cent developments in operator theory which affected the choice of topics, proofs and exercises. One ...

  15. Basics of aerothermodynamics

    CERN Document Server

    Hirschel, Ernst Heinrich

    2015-01-01

    This successful book gives an introduction to the basics of aerothermodynamics, as applied in particular to winged re-entry vehicles and airbreathing hypersonic cruise and acceleration vehicles. The book gives a review of the issues of transport of momentum, energy and mass, real-gas effects as well as inviscid and viscous flow phenomena. In this second, revised edition the chapters with the classical topics of aerothermodynamics more or less were left untouched. The access to some single topics of practical interest was improved. Auxiliary chapters were put into an appendix. The recent successful flights of the X-43A and the X-51A indicate that the dawn of sustained airbreathing hypersonic flight now has arrived. This proves that the original approach of the book to put emphasis on viscous effects and the aerothermodynamics of radiation-cooled vehicle surfaces was timely. This second, revised edition even more accentuates these topics. A new, additional chapter treats examples of viscous thermal surface eff...

  16. Nanodesign: some basic questions

    CERN Document Server

    Schommers, Wolfram

    2013-01-01

    There is no doubt that nanoscience will be the dominant direction for technology in this century, and that this science will influence our lives to a large extent as well as open completely new perspectives on all scientific and technological disciplines. To be able to produce optimal nanosystems with tailor-made properties, it is necessary to analyze and construct such systems in advance by adequate theoretical and computational methods. Since we work in nanoscience and nanotechnology at the ultimate level, we have to apply the basic laws of physics. What methods and tools are relevant here? The book gives an answer to this question. The background of the theoretical methods and tools is critically discussed, and also the world view on which these physical laws are based. Such a debate is not only of academic interest but is of highly general concern, and this is because we constantly move in nanoscience and nanotechnology between two extreme poles, between infinite life and total destruction . On the one ...

  17. [Basic research in pulmonology].

    Science.gov (United States)

    Gea, Joaquim

    2008-11-01

    This is a review of the articles dealing with basic science published in recent issues of Archivos de Bronconeumología. Of particular interest with regard to chronic obstructive pulmonary disease were an article on extrapulmonary inflammation and oxidative stress and another on bronchial remodeling. The articles relating to asthma included a review on the use of drugs that block free immunoglobulin-E and an article about the contribution of experimental models to our knowledge of this disease. Two of the most interesting articles on the topic of lung cancer dealt with gene therapy and resistance to chemotherapy. Also notable were 2 studies that investigated ischemia-reperfusion injury. One evaluated tissue resistance to injury while the other analyzed the role played by interleukin-8 in this process. On the topic of pulmonary fibrosis, an article focused on potential biomarkers of progression and prognosis; others dealt with the contribution of experimental models to our understanding of this disorder and the fibrogenic role of transforming growth factor b. In the context of both sleep apnea syndrome and pulmonary infection, studies investigating the role of oxidative stress were published. Finally, 2 studies analyzed the diagnosis and treatment of tuberculosis and other pulmonary infections.

  18. Basic Social Processes

    Directory of Open Access Journals (Sweden)

    Barney G. Glaser, PhD, Hon. PhD

    2005-06-01

    Full Text Available The goal of grounded theory is to generate a theory that accounts for a pattern of behavior that is relevant and problematic for those involved. The goal is not voluminous description, nor clever verification. As with all grounded theory, the generation of a basic social process (BSP theory occurs around a core category. While a core category is always present in a grounded research study, a BSP may not be.BSPs are ideally suited to generation by grounded theory from qualitative research because qualitative research can pick up process through fieldwork that continues over a period of time. BSPs are a delight to discover and formulate since they give so much movement and scope to the analyst’s perception of the data. BSPs such as cultivating, defaulting, centering, highlighting or becoming, give the feeling of process, change and movement over time. They also have clear, amazing general implications; so much so, that it is hard to contain them within the confines of a single substantive study. The tendency is to refer to them as a formal theory without the necessary comparative development of formal theory. They are labeled by a “gerund”(“ing” which both stimulates their generation and the tendency to over-generalize them.

  19. Gastric cancer: basic aspects.

    Science.gov (United States)

    Resende, Carlos; Thiel, Alexandra; Machado, José C; Ristimäki, Ari

    2011-09-01

    Gastric cancer (GC) is a world health burden, ranging as the second cause of cancer death worldwide. Etiologically, GC arises not only from the combined effects of environmental factors and susceptible genetic variants but also from the accumulation of genetic and epigenetic alterations. In the last years, molecular oncobiology studies brought to light a number of genes that are implicated in gastric carcinogenesis. This review is intended to focus on the recently described basic aspects that play key roles in the process of gastric carcinogenesis. Genetic variants of the genes IL-10, IL-17, MUC1, MUC6, DNMT3B, SMAD4, and SERPINE1 have been reported to modify the risk of developing GC. Several genes have been newly associated with gastric carcinogenesis, both through oncogenic activation (GSK3β, CD133, DSC2, P-Cadherin, CDH17, CD168, CD44, metalloproteinases MMP7 and MMP11, and a subset of miRNAs) and through tumor suppressor gene inactivation mechanisms (TFF1, PDX1, BCL2L10, XRCC, psiTPTE-HERV, HAI-2, GRIK2, and RUNX3). It also addressed the role of the inflammatory mediator cyclooxygenase-2 (COX-2) in the process of gastric carcinogenesis and its importance as a potential molecular target for therapy.

  20. Basic Data on Biogas

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2012-07-01

    Renewable gases such as biogas and biomethane are considered as key energy carrier when the society is replacing fossil fuels with renewable alternatives. In Sweden, almost 80 % of the fossil fuels are used in the transport sector. Therefore, the focus in Sweden has been to use the produced biogas in this sector as vehicle gas. Basic Data on Biogas contains an overview of production, utilisation, climate effects etc. of biogas from a Swedish perspective. The purpose is to give an easy overview of the current situation in Sweden for politicians, decision makers and interested public. 1.4 TWh of biogas is produced annually in Sweden at approximately 230 facilities. The 135 wastewater treatment plants that produce biogas contribute with around half of the production. In order to reduce the sludge volume, biogas has been produced at wastewater treatment plants for decades. New biogas plants are mainly co-digestion plants and farm plants. The land filling of organic waste has been banned since 2005, thus the biogas produced in landfills is decreasing.

  1. Biosimilar Insulins: Basic Considerations.

    Science.gov (United States)

    Heinemann, Lutz; Hompesch, Marcus

    2014-01-01

    Until now most of the insulin used in developed countries has been manufactured and distributed by a small number of multinational companies. Beyond the established insulin manufacturers, a number of new players have developed insulin manufacturing capacities based on modern biotechnological methods. Because the patents for many of the approved insulin formulations have expired or are going to expire soon, these not yet established companies are increasingly interested in seeking market approval for their insulin products as biosimilar insulins (BI) in highly regulated markets like the EU and the United States. Differences in the manufacturing process (none of the insulin manufacturing procedures are 100% identical) can lead to insulins that to some extent may differ from the originator insulin. The key questions are if subtle differences in the structure of the insulins, purity, and so on are clinically relevant and may result in different biological effects. The aim of this article is to introduce and discuss basic aspects that may be of relevance with regard to BI. © 2014 Diabetes Technology Society.

  2. 28 CFR 51.52 - Basic standard.

    Science.gov (United States)

    2010-07-01

    ... has the purpose or will have the effect of denying or abridging the right to vote on account of race... change if the Attorney General is unable to determine that the change is free of discriminatory purpose... change is conflicting and the Attorney General is unable to determine that the change is free...

  3. Why Did Socrates Deny That He Was a Teacher? Locating Socrates among the New Educators and the Traditional Education in Plato's "Apology of Socrates"

    Science.gov (United States)

    Mintz, Avi I.

    2014-01-01

    Plato's "Apology of Socrates" contains a spirited account of Socrates' relationship with the city of Athens and its citizens. As Socrates stands on trial for corrupting the youth, surprisingly, he does not defend the substance and the methods of his teaching. Instead, he simply denies that he is a teacher. Many scholars have…

  4. Basic Stand Alone Skilled Nursing Facility Beneficiary PUF

    Data.gov (United States)

    U.S. Department of Health & Human Services — This release contains the Basic Stand Alone (BSA) Skilled Nursing Facility (SNF) Beneficiary Public Use Files (PUF) with information from Medicare SNF claims. The...

  5. Basic Stand Alone Medicare Home Health Beneficiary PUF

    Data.gov (United States)

    U.S. Department of Health & Human Services — This release contains the Basic Stand Alone (BSA) Home Health Agency (HHA) Beneficiary Public Use Files (PUF) with information from Medicare HHA claims. The CMS BSA...

  6. Basic Stand Alone Medicare DME Line Items PUF

    Data.gov (United States)

    U.S. Department of Health & Human Services — This release contains the Basic Stand Alone (BSA) Durable Medical Equipment (DME) Line Items Public Use Files (PUF) with information from Medicare DME claims. The...

  7. The Obligation to Provide Free Basic Education in South Africa: An International Law Perspective

    Directory of Open Access Journals (Sweden)

    L Arendse

    2011-10-01

    Full Text Available In South Africa many learners are denied the right to basic education because of the levying of school fees and other educational charges, in spite of the international obligation imposed on government to provide free primary education. This article examines the exact nature and extent of this obligation by exploring the concept of "free" basic education. The applicable international instruments and their interpretation as well as the significance of the right to education as a central, facilitative right are examined in order to establish the content of the right to basic education and the legal obligations that ensue. Against this background, the implications of the South African Constitutional Court's approach to the realisation of socio-economic rights and the possibility of the establishment of a core minimum obligation are analysed. It is argued that learners in South Africa may come from different socio-economic backgrounds but as learners in the same public school domain and as equal bearers of their constitutional right to basic education all of them are entitled to the same type and quality of free basic education.

  8. Visual Basic 2012 programmer's reference

    CERN Document Server

    Stephens, Rod

    2012-01-01

    The comprehensive guide to Visual Basic 2012 Microsoft Visual Basic (VB) is the most popular programming language in the world, with millions of lines of code used in businesses and applications of all types and sizes. In this edition of the bestselling Wrox guide, Visual Basic expert Rod Stephens offers novice and experienced developers a comprehensive tutorial and reference to Visual Basic 2012. This latest edition introduces major changes to the Visual Studio development platform, including support for developing mobile applications that can take advantage of the Windows 8 operating system

  9. [Evolutionary medicine: an emergent basic science].

    Science.gov (United States)

    Spotorno, Angel E

    2005-02-01

    Evolutionary Medicine is an emergent basic science that offers new and varied perspectives to the comprehension of human health. The application of classic evolutionary theories (descent with modification, and natural selection) to the human organism, to its pathogens, and their mutual co-evolution, provides new explanations about why we get sick, how we can prevent this, and how we can heal. Medicine has focused mainly on the proximate or immediate causes of diseases and the treatment of symptoms, and very little on its evolutionary or mediate causes. For instance, the present human genome and phenotypes are essentially paleolithic ones: they are not adapted to modern life style, thus favoring the so-called diseases of civilization (ie: ateroesclerosis, senescence, myopia, phobias, panic attacks, stress, reproductive cancers). With the evolutionary approach, post-modern medicine is detecting better the vulnerabilities, restrictions, biases, adaptations and maladaptations of human body, its actual diseases, and its preventions.

  10. Combined effects of brain-derived neurotrophic factor immobilized poly-lactic-co-glycolic acid membrane with human adipose-derived stem cells and basic fibroblast growth factor hydrogel on recovery of erectile dysfunction.

    Science.gov (United States)

    Lee, Seung Hwan; Kim, In Gul; Jung, Ae Ryang; Shrestha, Kshitiz Raj; Lee, Jin Ho; Park, Ki Dong; Chung, Byung Ha; Kim, Sae Woong; Kim, Ki Hean; Lee, Ji Youl

    2014-09-01

    Erectile dysfunction (ED) is the most frequent long-term problem after radical prostatectomy. We aimed to evaluate whether the use of combination therapy with basic fibroblast growth factor (bFGF)-hydrogel on corpus cavernosum and with adipose-derived stem cells (ADSCs) and brain-derived neurotrophic factor (BDNF)-immobilized poly-lactic-co-glycolic acid (PLGA) membrane on the cavernous nerve (CN) could improve erectile function in a rat model of bilateral cavernous nerve crush injury (BCNI). Rats were randomly divided into five groups (n=15 per group): a normal group (N group), a group receiving saline application after bilateral cavernous nerve crush injury (BCNI), a group undergoing bFGF-hydrogel injection in the corpus cavernosum after BCNI (bFGF), a group receiving ADSC application covered with BDNF-membrane after BCNI (ADSC/BDNF), and a group undergoing coadministration of bFGF-hydrogel injection and BDNF-membrane with ADSCs after BDNF (bFGF+ADSC/BDNF). Four weeks postoperatively, the erectile function was assessed by detecting the ratio of intracavernous pressure (ICP) to mean arterial pressure (MAP). Smooth muscle and collagen contents were measured using Masson's trichrome staining. Neuronal nitric oxide synthase (nNOS) expression in the dorsal penile nerve was detected by immunostaining. The protein expression of the α-smooth muscle actin (α-SMA) and the cyclic guanosine monophosphate (cGMP) level of the corpus cavernosum were quantified by western blot and cGMP assay, respectively. In the bFGF+ADSC/BDNF group, the erectile function was significantly elevated compared with the BCNI and other treated groups and showed a significantly increased smooth muscle/collagen ratio, nNOS content, α-SMA expression, and cGMP level. In particular, there were no statistical differences in the ICP/MAP ratio, smooth muscle/collagen ratio, and α-SMA and cGMP levels between the bFGF+ADSC/BDNF group and normal group. Application of the BDNF-immobilized PLGA membrane with

  11. 重庆市基本公共卫生服务均等化人力资源的思考%A thinking of human resources in the basic public health service equalization of Chongqing

    Institute of Scientific and Technical Information of China (English)

    罗艳秋; 蒲川; 吴海峰; 何坪; 张维斌; 潘伦; 陈吕

    2013-01-01

    Objective To investigate the status quo of local public health officials in four districts and counties of Chongqing,analyze the problems in human resource allocation and use in the equalization of public health services,and put forward relevant coun-termeasures and suggestions. Methods Questionnaires and interviews were done in Municipal Health Bureaus,bureaus of finance, health and special public health organizations and 20 primary health organizations of 4 districts (counties) and their leaders by randomized sampling from 4 districts (counties) of Chongqing. Results Lack of public health technical personnel, service capacity needs to be improved,and management consciousness should be strengthened. Conclusion We should strengthen the recognition of basic public health services equalization work,enrich the public health talent team,improve the quality of public health and make the management personnel participate in the equalization actively.%目的 了解重庆市4个区(县)公共卫生人员现状,分析重庆市基本公共卫生服务均等化人力资源配置和使用方面存在的问题,提出相关的对策和建议.方法 采用随机抽样方法,选取4个区(县),问卷调查和访谈4区(县)卫生局、财政局、专业公共卫生机构和20个基层卫生机构及其相关负责人.结果 全市公共卫生技术人员缺乏,服务能力有待提高,管理人员意识有待加强.结论 加强重视基本公共卫生服务均等化工作,管理人员积极参与,充实公共卫生人才队伍,提高公共卫生队伍素质.

  12. Architectures de la petite industrie urbaine : l’exemple des Lilas (Seine-Saint-Denis

    Directory of Open Access Journals (Sweden)

    Nicolas Pierrot

    2007-03-01

    Full Text Available Les usines et les ateliers artisanaux repérés sur le territoire de la commune des Lilas ont été construits au cours du XXe siècle. A la différence de La Plaine-Saint-Denis, de ses industries lourdes, notamment chimiques et métallurgiques, à fortes emprises et génératrices d'emplois exigeant peu de qualification, Les Lilas accueillent à partir de la seconde moitié du XIXe siècle, à l'image des autres communes bordant Paris à l’est, des activités diversifiées recourant souvent à une main-d'œuvre qualifiée. Les entreprises, installées en grand nombre, sont ici disséminées en ateliers discrets : l'activité de production s'affirme peu, aux Lilas, par le décor. L’étude morphologique et architecturale permet de suivre l’évolution des ateliers et des usines, au fond des cours, le long des sentes, parfois sur la rue, et de comprendre les modalités de leur inscription dans le tissu urbain.The factories and artisans’ workshops surveyed in the suburban town of Les Lilas were built essentially during the XXth century. Unlike the town of La Plaine-Saint-Denis, whose heavy industry - namely chemical and metallurgical - generated a large unskilled workforce, Les Lilas attracted, from the second half of the XIXth century onward, numerous and varied industries that hired skilled workers. These companies were disseminated throughout the town in discreet workshops : ornate factories are not a "Lilasian" tradition. A morphological and architectural study allows us to follow the evolution of the workshops and factories found in back courtyards, along alleys or sometimes more visibly located, and to understand the different ways they wove themselves into the urban fabric of Les Lilas.

  13. Basic Learning Processes in Childhood.

    Science.gov (United States)

    Reese, Hayne W.

    This book is an introduction to the psychological study of basic learning processes in children. Written for students who are not majors in psychology and who do not have much familiarity with the technical vocabulary of psychology, it has two themes: even the most basic kinds of learning are included by cognitive processes or mental activities;…

  14. Japanese Basic Course: Exercise Book.

    Science.gov (United States)

    Defense Language Inst., Washington, DC.

    This exercise book, prepared for use after Lesson 121 of the Defense Language Institute Basic Course in Japanese, provides for instruction in the use of Kanji dictionaries, familiarizes students with useful phrases and expressions that are not included in the Basic Course, and allows for greater variety in the classroom. The ten lessons, in the…

  15. Basic sciences: an alternative career?

    Science.gov (United States)

    Khatri, R

    2013-01-01

    Career selection is a crucial and a complex process which is also true for the medical profession. In the context of our country, due to the limited opportunity and proper guidance, migration of medical graduates to foreign countries is increasing. Though, clinical subjects have a huge attraction, basic science field has failed to impress our medical graduates. In current scenario, basic science field seems to be a dumping site for the incompetent as the candidates who have failed trying their luck elsewhere stumble upon basic science careers though it is not true for all. Moreover, a very few medical graduates are interested in developing their career as a basic scientist. Therefore, to motivate today's young medical graduates, there is a need of a good mentor along with a proper career guidance which can help them to understand the basic science field as an alternative career.

  16. Religious World-Denying and Trajectories of Activism in the Field of Strongly-Religious Corporative Actors

    Directory of Open Access Journals (Sweden)

    Olga Michel

    2014-03-01

    Full Text Available This comparative case study links together the scholarly discourses on religiously-motivated world-rejecting and religious activism. It provides empirical evidence for differentiation between four ideal-typed patterns of religious activism as they relate to different trajectories and spheres of religious world-denying in strongly religious movements: Pattern I (world conquerors targets inner-worldly sphere of activism in the particular state, using the full scope of political tools to promote its religiously-fueled political agenda. Pattern II (world transformers creatively combines inner-worldly and other-worldly spheres of activism, applying political strategies in the most advantageous political situations and primarily focusing on strategic missionary activism in “the world.” Pattern III (world creators utilizes different forms of civic engagement to re-create “the righteous world” on the congregational level, but also participates in missionary activities. Finally, pattern IV (world renouncers renounces any inner-worldly forms of political or civic engagement as “sinful activity.”

  17. A model for the overwintering process of European grapevine moth Lobesia botrana (Denis & Schiffermüller (Lepidoptera, Tortricidae populations

    Directory of Open Access Journals (Sweden)

    Johann Baumgärtner

    2012-05-01

    Full Text Available The paper deals with the development, parametrization and validation of a phenology model of the overwintering process of European grapevine moth Lobesia botrana (Denis & Schiffermüller populations in northern latitudes. The model is built on diapause and poikilothermic population development theories and represents the phenological events of entries into and emergence from pre-diapause, diapause and post-diapause phases. The rate sum models for pre-diapause and post-diapause development are based on published non-linear temperature dependent rate functions. The rate sum model for diapause, however, is negatively affected by the photoperiod during diapause and positively influenced by the photoperiod at the time of diapause entry. The diapause model is parametrized with 3-year data from 25 locations in Europe and Cyprus, and validated with 1-3 year observations from 18 locations in Europe and California. Despite restrictive assumptions and limitations imposed by weather data recorded at variable distances from the observation sites, and the variable qualities of observation data, the model’s predictive and explanatory capabilities are useful for adaptive pest management and assessments of the invasive potential. The need for controlled experiments is recognized and suggestions are made for improving the model.

  18. Dengue disease, basic reproduction number and control

    CERN Document Server

    Rodrigues, Helena Sofia; Torres, Delfim F M; Zinober, Alan; 10.1080/00207160.2011.554540

    2011-01-01

    Dengue is one of the major international public health concerns. Although progress is underway, developing a vaccine against the disease is challenging. Thus, the main approach to fight the disease is vector control. A model for the transmission of Dengue disease is presented. It consists of eight mutually exclusive compartments representing the human and vector dynamics. It also includes a control parameter (insecticide) in order to fight the mosquito. The model presents three possible equilibria: two disease-free equilibria (DFE) and another endemic equilibrium. It has been proved that a DFE is locally asymptotically stable, whenever a certain epidemiological threshold, known as the basic reproduction number, is less than one. We show that if we apply a minimum level of insecticide, it is possible to maintain the basic reproduction number below unity. A case study, using data of the outbreak that occurred in 2009 in Cape Verde, is presented.

  19. Radioimmunoassay in basic and clinical pharmacology

    Energy Technology Data Exchange (ETDEWEB)

    Patrono, C.; Peskar, B.A.

    1987-01-01

    The subject of the book is the development, validation and application of radioimmunoassay (RIA) techniques for the measurement of a variety of substances in animal and human body fluids. The book discusses methodological and conceptual issues related to the main classes of mediators of drug action and to drugs themselves, as assayed by this particular analytical technique. A number of introductory chapters provide basic information concerning production and characterization of antibodies, labeling techniques, statistical aspects and validation criteria, insight into problems related to the development and validation of RIA for the newly discovered mediator(s). In the following chapters, the emphasis is placed on the technical details relevant to each class of compounds and on specific aspects of their applications to basic and/or clinical pharmacological studies. New developments in this area, such as monoclonal antibodies and non-radioactive labeling techniques, are also covered.

  20. Molecular neurodegeneration: basic biology and disease pathways.

    Science.gov (United States)

    Vassar, Robert; Zheng, Hui

    2014-09-23

    The field of neurodegeneration research has been advancing rapidly over the past few years, and has provided intriguing new insights into the normal physiological functions and pathogenic roles of a wide range of molecules associated with several devastating neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, frontotemporal dementia, Huntington's disease, and Down syndrome. Recent developments have also facilitated initial efforts to translate preclinical discoveries toward novel therapeutic approaches and clinical trials in humans. These recent developments are reviewed in the current Review Series on "Molecular Neurodegeneration: Basic Biology and Disease Pathways" in a number of state-of-the-art manuscripts that cover themes presented at the Third International Conference on Molecular Neurodegeneration: "Basic biology and disease pathways" held in Cannes, France, September, 2013.

  1. Discrete Neural Signatures of Basic Emotions.

    Science.gov (United States)

    Saarimäki, Heini; Gotsopoulos, Athanasios; Jääskeläinen, Iiro P; Lampinen, Jouko; Vuilleumier, Patrik; Hari, Riitta; Sams, Mikko; Nummenmaa, Lauri

    2016-06-01

    Categorical models of emotions posit neurally and physiologically distinct human basic emotions. We tested this assumption by using multivariate pattern analysis (MVPA) to classify brain activity patterns of 6 basic emotions (disgust, fear, happiness, sadness, anger, and surprise) in 3 experiments. Emotions were induced with short movies or mental imagery during functional magnetic resonance imaging. MVPA accurately classified emotions induced by both methods, and the classification generalized from one induction condition to another and across individuals. Brain regions contributing most to the classification accuracy included medial and inferior lateral prefrontal cortices, frontal pole, precentral and postcentral gyri, precuneus, and posterior cingulate cortex. Thus, specific neural signatures across these regions hold representations of different emotional states in multimodal fashion, independently of how the emotions are induced. Similarity of subjective experiences between emotions was associated with similarity of neural patterns for the same emotions, suggesting a direct link between activity in these brain regions and the subjective emotional experience.

  2. sUAS Position Estimation and Fusion in GPS-Degraded and GPS-Denied Environments using an ADS-B Transponder and Local Area Multilateration

    Science.gov (United States)

    Larson, Robert Sherman

    An Unmanned Aerial Vehicle (UAV) and a manned aircraft are tracked using ADS-B transponders and the Local Area Multilateration System (LAMS) in simulated GPS-degraded and GPS-denied environments. Several position estimation and fusion algorithms are developed for use with the Autonomous Flight Systems Laboratory (AFSL) TRansponder based Position Information System (TRAPIS) software. At the lowest level, these estimation and fusion algorithms use raw information from ADS-B and LAMS data streams to provide aircraft position estimates to the ground station user. At the highest level, aircraft position is estimated using a discrete time Kalman filter with real-time covariance updates and fusion involving weighted averaging of ADS-B and LAMS positions. Simulation and flight test results are provided, demonstrating the feasibility of incorporating an ADS-B transponder on a commercially-available UAS and maintaining situational awareness of aircraft positions in GPS-degraded and GPS-denied environments.

  3. Quarantine and Identification of Lobesia botrana (Denis & Schiffermüller)%检疫性有害生物--葡萄花翅小卷蛾

    Institute of Scientific and Technical Information of China (English)

    牛春敬; 刘勇; 廖芳

    2013-01-01

    在国内首次提出了葡萄花翅小卷蛾Lobesia botrana(Denis&Schiffermüller)的鉴定依据,并提供该种害虫详细的形态特征、生物学特性以及危害特点等信息,以期使读者较全面地了解葡萄花翅小卷蛾的经济重要性,为进一步研究、检疫和防治该种害虫提供参考。%Identification of Lobesia botrana (Denis&Schiffermüller) with morphological characteristics, biological and damage features is provided first in China in the present paper to fully understand the economic importance and to give a reference for further research, inspection and quarantine and control of this pest.

  4. Proposing a Technical Solution for Restoring Longitudinal Connectivity in the Brădeni/Retiş Accumulation Area on Hârtibaciu River

    Directory of Open Access Journals (Sweden)

    Voicu Răzvan

    2016-04-01

    Full Text Available The fish fauna of the Hârtibaciu River has experienced a disrupted connectivity due to the hydrotechnical works and the Brădeni/Retiş Dam located across the Hârtibaciu watercourse being one of this significant obstacles. The newly proposed constructed wetlands can improve the habitat quality for the fish species of conservative interest sampled in the Brădeni/Retiş Dam proximity Rhodeus amarus, and can increase the individuals’ number of this population. Also can benefit the local populations of Phoxinus phoxinus and Gobio obtusirostris. Using gravitational force and also the underground layout, a proposed technical solution gives maximum safety regarding the water supply for the newly proposed to be created wetlands.

  5. Fed up with the right to food? : The Netherlands' policies and practices regarding the human right to adequate food

    NARCIS (Netherlands)

    Hospes, O.; Meulen, van der B.M.J.

    2009-01-01

    There is no one in this world who would deny the importance of access to adequate food for every human being. In fact, access to food has been declared a human right in 1948 with the Universal Declaration of Human Rights. In spite of the right to food to be more than half a century old, many are not

  6. Fed up with the right to food? : The Netherlands' policies and practices regarding the human right to adequate food

    NARCIS (Netherlands)

    Hospes, O.; Meulen, van der B.M.J.

    2009-01-01

    There is no one in this world who would deny the importance of access to adequate food for every human being. In fact, access to food has been declared a human right in 1948 with the Universal Declaration of Human Rights. In spite of the right to food to be more than half a century old, many are not

  7. Environmental Change and Human Migration

    Directory of Open Access Journals (Sweden)

    Milan Mesić

    2014-12-01

    Full Text Available The 30th anniversary of the journal Migration and Ethnic Themes (MET is an occasion to announce a new key issue in the modern world’s future, which, in the authors’ opinion, is becoming the central theme within multidisciplinary and interdisciplinary field of migration studies. This concerns the displacement of people in the local and national context as well as migration across national borders, at the regional and global level, which are directly or indirectly caused by environmental change. The recent genetic studies on the origins and development of the human race further confirm that the human ecological migrations are the first and the oldest type of migrations at all. In addition, as archaeological and other findings suggest, just this type of migration sometimes played a key role in the emergence, decay and changing of ancient civilizations. It seems that the early researchers of migration studies had a lot in mind considering changes in natural environment as an important determinant of human spatial movements. The interest for this topic in the social sciences had trailed off until the re-emergence in the second half of the 1980s. The authors accept the classification on the causal categories of “environmental migration” as: a “natural” disasters; b “urban-industrial” disasters, and c exploitation and degradation of resources. Further, they deal with the definition of basic concepts, first of all with disputes about the definition of “environmental refugees” as opposed to “environmental migrants”. Finally, the authors systematize two major competing approaches to migration and migrants caused by environmental change. The first one is “the alarmist” and the second one “the sceptic” approach. Luckily, the Sceptics are able (for now to prove that deterrent worse-case scenarios on increasingly powerful and unstoppable “waves” of environmental migrants (refugees have not been achieved. This serves them as

  8. Writing for publication: the basics.

    Science.gov (United States)

    Fahy, Kathleen

    2008-06-01

    Most midwives and nurses do not write for publication. Previous authors on this topic have focussed on the processes of writing and getting published. Although definitive English usage style guides exist, they are infrequently consulted by new midwifery authors. To enable new writers to confidently apply the basic skills of scientific writing when preparing a paper for publication. The basic skills needed for scientific writing are the focus of this paper. The importance of careful word choices is discussed first. Next, the skills of writing sentences are presented. Finally, the skills of writing paragraphs are discussed. Examples of poor and better writing are given in relation to each of these basic elements.

  9. The basic aerodynamics of floatation

    Energy Technology Data Exchange (ETDEWEB)

    Davies, M.J.; Wood, D.H.

    1983-09-01

    The original derivation of the basic theory governing the aerodynamics of both hovercraft and modern floatation ovens, requires the validity of some extremely crude assumptions. However, the basic theory is surprisingly accurate. It is shown that this accuracy occurs because the final expression of the basic theory can be derived by approximating the full Navier-Stokes equations in a manner that clearly shows the limitations of the theory. These limitations are used in discussing the relatively small discrepancies between the theory and experiment, which may not be significant for practical purposes.

  10. Do ambient urban odors evoke basic emotions?

    Science.gov (United States)

    Glass, Sandra T; Lingg, Elisabeth; Heuberger, Eva

    2014-01-01

    Fragrances, such as plant odors, have been shown to evoke autonomic response patterns associated with Ekman's (Ekman et al., 1983) basic emotions happiness, surprise, anger, fear, sadness, and disgust. Inducing positive emotions by odors in highly frequented public spaces could serve to improve the quality of life in urban environments. Thus, the present study evaluated the potency of ambient odors connoted with an urban environment to evoke basic emotions on an autonomic and cognitive response level. Synthetic mixtures representing the odors of disinfectant, candles/bees wax, summer air, burnt smell, vomit and musty smell as well as odorless water as a control were presented five times in random order to 30 healthy, non-smoking human subjects with intact sense of smell. Skin temperature, skin conductance, breathing rate, forearm muscle activity, blink rate, and heart rate were recorded simultaneously. Subjects rated the odors in terms of pleasantness, intensity and familiarity and gave verbal labels to each odor as well as cognitive associations with the basic emotions. The results showed that the amplitude of the skin conductance response (SCR) varied as a function of odor presentation. Burnt smell and vomit elicited significantly higher electrodermal responses than summer air. Also, a negative correlation was revealed between the amplitude of the SCR and hedonic odor valence indicating that the magnitude of the electrodermal response increased with odor unpleasantness. The analysis of the cognitive associations between odors and basic emotions showed that candles/bees wax and summer air were specifically associated with happiness whereas burnt smell and vomit were uniquely associated with disgust. Our findings suggest that city odors may evoke specific cognitive associations of basic emotions and that autonomic activity elicited by such odors is related to odor hedonics.

  11. Do ambient urban odors evoke basic emotions?

    Directory of Open Access Journals (Sweden)

    Sandra Theresia Weber-Glass

    2014-04-01

    Full Text Available Fragrances, such as plant odors, have been shown to evoke autonomic response patterns associated with Ekman’s (Ekman et al., 1983 basic emotions happiness, surprise, anger, fear, sadness and disgust. Inducing positive emotions by odors in highly frequented public spaces could serve to improve the quality of life in urban environments. Thus, the present study evaluated the potency of ambient odors connoted with an urban environment to evoke basic emotions on an autonomic and cognitive response level. Synthetic mixtures representing the odors of disinfectant, candles / bees wax, summer air, burnt smell, vomit and musty smell as well as odorless water as a control were presented five times in random order to 30 healthy, non-smoking human subjects with intact sense of smell. Skin temperature, skin conductance, breathing rate, forearm muscle activity, blink rate and heart rate were recorded simultaneously. Subjects rated the odors in terms of pleasantness, intensity and familiarity and gave verbal labels to each odor as well as cognitive associations with the basic emotions. The results showed that the amplitude of the skin conductance response varied as a function of odor presentation. Burnt smell and vomit elicited significantly higher electrodermal responses than summer air. Also, a negative correlation was revealed between the amplitude of the skin conductance response and hedonic odor valence indicating that the magnitude of the electrodermal response increased with odor unpleasantness. The analysis of the cognitive associations between odors and basic emotions showed that candles / bees wax and summer air were specifically associated with happiness whereas burnt smell and vomit were uniquely associated with disgust. Our findings suggest that city odors may evoke specific cognitive associations of basic emotions and that autonomic activity elicited by such odors is related to odor hedonics.

  12. Tomoceridae (Collembola, Entomobryomorpha from the southern Annamitic cordillera: redescription of Tomocerus ocreatus Denis, 1948 and description of a new species of Tomocerina Yosii, 1955

    Directory of Open Access Journals (Sweden)

    Daoyuan Yu

    2016-02-01

    Full Text Available Two species of Tomoceridae were found near Dalat, southern Vietnam. Tomocerus ocreatus Denis, 1948 is redescribed based on a neotype specimen. Previous records of Tomocerus ocreatus in non-type localities are reevaluated. A new species Tomocerina annamitica sp. nov. is described. The new species is mainly characterized by its small body size, pointed tenent hair, compound dental spines and the absence of intermediate teeth on mucro.

  13. The ultracool dwarf DENIS-P J104814.7-395606. Chromospheres and coronae at the low-mass end of the main-sequence

    CERN Document Server

    Stelzer, B; Biazzo, K; Ercolano, B; Crespo-Chacon, I; Lopez-Santiago, J; Martinez-Arnaiz, R; Schmitt, J H M M; Rigliaco, E; Leone, F; Cupani, G

    2011-01-01

    We have obtained an XMM-Newton observation and a broad-band spectrum from the ultraviolet to the near infrared with X-Shooter for one of the nearest M9 dwarfs, DENIS-P J1048-3956 (4pc). We integrate these data by a compilation of activity parameters for ultracool dwarfs from the literature with the aim to advance our understanding of these objects by comparing them to early-M type dwarf stars and the Sun. Our deep XMM-Newton observation has led to the first X-ray detection of DENIS-P J1048-3956 (log Lx = 25.1) as well as the first measurement of its V band brightness (V = 17.35mag). Flux-flux relations between X-ray and chromospheric activity indicators are here for the first time extended into the regime of the ultracool dwarfs. The approximate agreement of DENIS-P J1048-3956 and other ultracool dwarfs with flux-flux relations for early-M dwarfs suggests that the same heating mechanisms work in the atmospheres of ultracool dwarfs, albeit weaker as judged from their lower fluxes. The observed Balmer decrement...

  14. Dental Health: The Basic Facts

    Science.gov (United States)

    Dental Health THE BASIC FACTS MULTIPLE SCLEROSIS Kim, diagnosed in 1986 People with a chronic disease may neglect their general health and wellness, research shows. Dental care is no exception. A tendency to focus ...

  15. Basic properties of Fedosov supermanifolds

    CERN Document Server

    Geyer, B

    2004-01-01

    Basic properties of even (odd) supermanifolds endowed with a connection respecting a given symplectic structure are studied. Such supermanifolds can be considered as generalization of Fedosov manifolds to the supersymmetric case.

  16. Basic principles of concrete structures

    CERN Document Server

    Gu, Xianglin; Zhou, Yong

    2016-01-01

    Based on the latest version of designing codes both for buildings and bridges (GB50010-2010 and JTG D62-2004), this book starts from steel and concrete materials, whose properties are very important to the mechanical behavior of concrete structural members. Step by step, analysis of reinforced and prestressed concrete members under basic loading types (tension, compression, flexure, shearing and torsion) and environmental actions are introduced. The characteristic of the book that distinguishes it from other textbooks on concrete structures is that more emphasis has been laid on the basic theories of reinforced concrete and the application of the basic theories in design of new structures and analysis of existing structures. Examples and problems in each chapter are carefully designed to cover every important knowledge point. As a basic course for undergraduates majoring in civil engineering, this course is different from either the previously learnt mechanics courses or the design courses to be learnt. Compa...

  17. Complementary Basic Education in Tanzania

    OpenAIRE

    大津, 和子

    2001-01-01

    This paper discusses current development in the Complementary Basic Education program (COBET), which aims to contribute to the provision of alternative learning opportunities for out-of-school children, particularly girls in a non-formal setting. The Ministry of Education and Culture started the program as part of the Basic Education Master Plan (BEMP) in 1999. Unlike traditional primary schools, the COBET centers have no school fees, no uniforms, no corporal punishment and no child labou...

  18. Mind the Gap: Appropriate Evolutionary Perspectives toward the Integration of the Sciences and Humanities

    Science.gov (United States)

    Heywood, Leslie L.; Garcia, Justin R.; Wilson, David Sloan

    2010-01-01

    Although Darwinism has gained a foothold in the social sciences, in the humanities, with a few exceptions, it is still largely rejected--not, as some would claim, because humanists are all radical poststructuralists who deny that material reality exists, but rather because, with notable exceptions, Darwinists who work within the humanities have…

  19. Denys Lasdun y el proyecto para la Universidad East Anglia Síntesis de una filiación orgánica

    Directory of Open Access Journals (Sweden)

    Patricia de Diego Ruiz

    2015-05-01

    Full Text Available ResumenEl trabajo de Denys Lasdun ha sido tradicionalmente valorado por su gran calidad espacial, su elegancia y su capacidad para desarrollar un nuevo lenguaje tectónico. Sin embargo, Alvin Boyarsky define la arquitectura de Lasdun como una arquitectura de etcétera, lo que implica que sus  proyectos fueran conceptualmente complejos, llenos de matices y signifi cados, y con una afi liación importante hacia el mundo natural. Siguiendo esta apreciación, estudiaremos el proyecto de la Universidad de East Anglia en Norwich como epítome de un importante objetivo oculto que guió la genealogía y objetivos sociales de algunas de las obras más notables del arquitecto Inglés.Mucho más allá de la analogía biológica, analizaremos el interés de  Lasdun en los procesos naturales más allá del marco positivista y científico habitual. Su comprensión de los vínculos y resonancias entre arquitectura y naturaleza, engloba también la esfera humana y social. Es un concepto más amplio de la vida el que da forma a una visión intuitiva, libre y global de la arquitectura de posguerra de Lasdun. También consciente de la introducción en Inglaterra del discurso orgánico de Bruno Zevi, Lasdun fusiona ambas fuentes como contrapunto a la práctica más académica y conformista amparada en las necesidades pragmáticas y sus realidades sociales.De esta manera, desarrolla un discurso personal y un léxico que pone en práctica en sus proyectos de los años cincuenta y sesenta, que culmina con la Universidad de East Anglia como un protoorganismo. A través de este proyecto, y algunas obras anteriores profundamente relacionadas, Lasdun investiga posibilidades formales y estructurales para pensar la obra de arquitectura como un sistema no cerrado, sino capaz de crecer y cambiar; como un proyecto inconcluso y adaptable listo para responder a las circunstancias, objetivos y necesidades y humanas. AbstractThe work of Denys Lasdun has been traditionally

  20. BIOECOLOGY OF DIORYCTRIA ABIETELLA DENIS AND SCHIFF. A PEST OF CONIFERS IN THE NORTH-WESTERN HIMALAYA

    Directory of Open Access Journals (Sweden)

    T.D. VERMA

    1994-01-01

    Full Text Available Cones and seeds of conifers, such as Pinus roxburghii, P. wallichiana, P. gerardiana, Cedrus deodara, Abies pindrow and Picea smithiana are seriously damaged by Dioryctria abietella Denis and Schiff. (Lepidoptera : Pyralidae in the North-Western Himalayan region of India. Bioecological studies carried out during 1991 - '92 revealed that the females laid whitish, elliptical eggs singly on the depressed surface of the young cones. The average egg size was 1.00 ± 0.11 x 0.60 ±0.08 mm and this stage lasted for 3 - 5 days. The larval stage passed through five instars. All the instars differed in appearance, size and duration and larvae became full-fed in an average of 24.8 ± 1.9 days. The full-fed larva spun a cocoon around itself, sealed it with white papery membrane and pupated inside the cone or any other outside protected place. The prepupal and pupal periods lasted for 7-8 and 10-14 days, respectively. The pupa was dark brown, 13.8 ± 0.07 mm in length. Total period from egg to adult varied from 46 to 59 days (52.7 ±4.8 days. Adults were dirty brown in appearance and were 13.59±0.115 mm long with an average wing expanse of 29.0 ± 1.00 mm. They lived for 4 to 5 days. Under laboratory conditions, the pest completed two generations per year and full-fed larvae of 3rd generation overwintered during September - October. Two larval parasites belonging to order Hymenoptera and Diptera, and a fungal pathogen (Fusarium sp. were found associated with this pest. The detailed biology, nature and extent of damage, along with its distribution have been discussed and methods of control suggested.