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  1. 5. Neuromarketing: uma nova disciplina acadêmica?

    Directory of Open Access Journals (Sweden)

    Eric David Cohen

    2017-12-01

    Full Text Available Através da aplicação de técnicas neurocientíficas, o Neuromarketing busca entender como ocorrem os processos de decisão de compra. Verifica-se que há um grande movimento em torno do Neuromarketing no ambiente empresarial, apontando que o desenvolvimento desta nova área de conhecimento, bem como a sua possível autonomia, estão em desenvolvimento. Por meio de um estudo exploratório, mapeou-se a construção deste campo de conhecimento no tempo, levando à formação de uma possível nova disciplina científica e acadêmica, assim como verificar a sua origem interdisciplinar. Ademais, apresenta-se a construção de um mapa a partir de dados secundários, de modo a demonstrar a percepção da história e das contribuições potenciais do Neuromarketing, a partir de uma análise da produção científica na área. A partir de um conjunto de dados levantados, conclui-se que existe uma dinâmica de construção do Neuromarketing em torno dos diferentes atores na academia e nos negócios, levando à formulação de hipóteses quanto à maturidade desta nova disciplina acadêmica.

  2. Dengue hemorrágico en el niño Dengue hemorrágica na criança

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    Carlos Dotres Martinez

    1987-06-01

    Full Text Available Foi realizada uma revisão completa da Dengue Hemorrágica, doença infecciosa viral aguda e potencialmente, grave, transmitida por mosquito, que, em 1981, causou a morte de 158 pessoas durante uma epidemia em Cuba, sendo 101 menores de 15 anos. A Dengue, em sua forma clássica (benigna, foi primeiramente referida em 1823, porém,no ano de 1953, em Manila, Filipinas, se registrou uma nova apresentação da doença, caracterizada por manifestações hemorrágicas, choque e alta mortalidade que se denominou Febre Hemorrágica Dengue e Síndrome de Choque por Dengue (FHD/SSD. Sua patogenia é apresentada, discutindo-se também a possibilidade de repetição do fenômeno nas Américas.A thorough revision on hemorragic dengue fever is presented. Dengue, an acute mosquito-borne infectious disease has occurred in epidemic form in Cuba 1981, causing death of 158 persons. The disease in its classical form was first reported in 1823 but in 1953 a new presentation characterized by hemorrhagic manifestations, shock and a high mortality was observed in Manila, Phillipines. This form was called Hemorrhagic Dengue Fever and Dengue Shock Syndrome (HDF/DSS. Its pathogenesis can be explained by two different theories: it could be a primary infection or a hipersensibility reaction depending on a previous infection.

  3. Por uma 'nova pragmática emancipatória'

    OpenAIRE

    Ferreira,Dina Maria Martins; Alencar,Claudiana Nogueira de

    2013-01-01

    Neste artigo propomos o modus operandi de uma pragmática contra-hegemônica no que tange às teorias do mainstream, ou seja, as internalistas (auto-suficiência da língua como sistema) e as externalistas (aspecto social aliado à língua e não constitutivo da língua). Para tal, constroem-se dois percursos argumentativos para dar conta de uma nova Pragmática emancipatória: (1) nova, que mostra a incompatibilidade conceitual entre a teoria austiniana e a interpretada por seu discípulo Searle; (2) em...

  4. 5. Neuromarketing: uma nova disciplina acadêmica?

    OpenAIRE

    Eric David Cohen; Gabriela Guimarães Lima; Peter Alexander Bleinroth Schulz

    2017-01-01

    Através da aplicação de técnicas neurocientíficas, o Neuromarketing busca entender como ocorrem os processos de decisão de compra. Verifica-se que há um grande movimento em torno do Neuromarketing no ambiente empresarial, apontando que o desenvolvimento desta nova área de conhecimento, bem como a sua possível autonomia, estão em desenvolvimento. Por meio de um estudo exploratório, mapeou-se a construção deste campo de conhecimento no tempo, levando à formação de uma possível nova disciplina c...

  5. Uma nova interpretação de um auto de Gil Vicente

    OpenAIRE

    Silva, Isa Alexandra Marques da

    2009-01-01

    Neste trabalho, intitulado Uma nova interpretação de Um Auto de Gil Vicente, cedo lugar a uma reflexão sumária em torno da história do Teatro, como ponto de partida para a tragicomédia vicentina, denominada As Cortes de Júpiter, sobre a qual Garrett introduz o seu Auto de ―meditação‖ cultural. A partir do exemplo garrettiano, aproveitamos a oportunidade para ressaltar, especialmente, o grande deficit do nosso País na época do autor, do qual podemos verificar ainda alguns reflexos na actualida...

  6. 'Haruna': uma nova mutação somática natural da videira 'Itália'

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    Adriane Marinho de Assis

    2013-03-01

    Full Text Available O objetivo deste estudo foi descrever as principais características físico-químicas e produtivas da uva fina de mesa 'Haruna', uma nova mutação natural originada da cv. Itália, em Uraí-PR, Brasil. O formato das bagas, elipsoide alongado bastante expressivo, é uma das características que mais difere essa nova mutação da uva 'Itália'. As bagas apresentam coloração verde-clara, tendendo ao amarelo na maturação plena, com pincel e polpa verde, crocante, firme, textura carnosa e de sabor moscatel, enquanto os cachos apresentam formato cilíndrico-cônico. O ciclo, bem como o desempenho produtivo e a suscetibilidade às doenças fúngicas assemelham- se aos da cv. Itália. Durante a maturação plena, apresenta teor médio de sólidos solúveis de 16,2ºBrix, superior à 'Itália, 0,5% de ácido tartárico e índice de maturação de 31,2. Trata-se de uma nova cultivar de uva fina de mesa com bom potencial de cultivo no Brasil.

  7. Monitoramento de informação em mídias sociais: o e-Monitor Dengue

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    Michele Nacif Antunes

    Full Text Available Este artigo apresenta os resultados preliminares da pesquisa "Monitoramento de informação sobre doenças negligenciadas: o e-Monitor Dengue". O e-Monitor Dengue é um sistema de monitoramento de informação na Internet feito por meio de um mecanismo robô, software ou agente inteligente que vasculha os sites sobre dengue disponíveis na Internet. Resultados de pesquisas anteriores indicaram novas perspectivas para o monitoramento, principalmente, por meio das mídias sociais. Dentre as mídias sociais, considera-se que o Twitter pode desempenhar um papel na gestão da informação ao permitir identificar usuários que podem atuar como filtro de informação, sendo possível acessar diretamente a informação mais relevante para uma determinada área de interesse. Assim, a partir do monitoramento do Twitter, a primeira pergunta a ser respondida no âmbito da pesquisa em andamento foi "Quem fala sobre dengue?". Inicialmente, foi possível identificar a relação dos atores/perfis localizados na cidade do Rio de Janeiro e Niterói com maior ocorrência do termo "dengue" em suas mensagens. Os perfis foram cadastrados no sistema de monitoramento e são monitorados constantemente. Outra pergunta a ser respondida foi "Quando se fala de dengue?". Observa-se que o número de twetts acompanha o crescimento do número de casos de dengue. São indícios de que há uma relação entre os rumores sobre dengue e o aumento de número de casos notificados. Evidencia-se, desta forma, que realizar o monitoramento nas mídias sociais durante o período de epidemia e fazer sua relação com a situação epidemiológica da dengue pode ser uma estratégia importante para as autoridades em vigilância epidemiológica.

  8. Lei das arqueações de 1684: por uma nova interpretação

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    Salles, Wesley Dartagnan

    2011-01-01

    Full Text Available Neste artigo propõe-se uma nova maneira de interpretar a “lei das arqueações de 1684”. Acredita-se que sua elaboração esteve imbricada numa série de acontecimentos conseguintes ao fim da União-Ibérica, ou seja, mostra-se o processo de sua elaboração. Dessa forma, ao se seguir esse viés, a pesquisa entra em conflito com as interpretações da lei de 1684, cujo foco principal foi ponderar o caráter humanitário do Estado Português, na medida em que a lei procurou proteger os escravos durante o seu transporte marítimo. Ao se propor uma nova forma de abordá-la não se nega que ela surgiu para proteger os escravos, o que se questiona são os porquês do interesse em proteger os negros no tráfico, sobretudo em 1684. Assim, a pesquisa transcende a análise de uma lei sobre o tráfico negreiro e cria ferramentas para se compreender a maneira que o Estado lusitano pensava a escravidão naquele contexto

  9. O superego: em busca de uma nova abordagem

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    Marta Rezende Cardoso

    Full Text Available Este artigo apresenta a proposição de uma nova concepção do superego, segundo a qual os imperativos superegóicos seriam comparáveis, em todos os indivíduos, a um “enclave psicótico”. Trata-se aqui de aprofundar aspectos fundamentais da questão do superego, numa tentativa de elaborar alguns pontos que ficaram problemáticos em Freud, Melanie Klein e outros autores pós-freudianos. A obra de Jean Laplanche foi útil como fonte principal na formulação das hipóteses apresentadas cuja incidência na clínica psicanalítica parece inegável.

  10. Dengue virus type 3 isolation from Aedes aegypti in the municipality of Nova Iguaçu, State of Rio de Janeiro

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    Ricardo Lourenço-de-Oliveira

    2002-09-01

    Full Text Available In a prospective field study conducted from July 2000 to June 2001, adult Aedes aegypti and Ae. albopictus mosquitoes were caught from the municipality of Nova Iguaçu, State of Rio de Janeiro, Brazil. Virus isolation in Ae. albopictus clone C6/36 cell line and a semi-nested reverse transcription-polymerase chain reaction detected only dengue virus type 3 in three pools of Ae. aegypti, despite the co-circulation of DEN-1, DEN-2 and DEN-3 serotypes in that area. No viruses were detected in Ae. albopictus mosquitoes. This virological surveillance consists in a sentinel system alerting for dengue outbreaks.

  11. EDUCAÇÃO DE JOVENS E ADULTOS E NOVAS TECNOLOGIAS DA INFORMAÇÃO: UMA ABORDAGEM EDUCACIONAL

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    Cristiana Barcelos da Silva

    2016-04-01

    Full Text Available A instituição escolar tem sido apontada como o lócus de estudos e análises de fenômenos educacionais. As implicações aqui discutidas fizeram parte de uma pesquisa cujo objetivo foi compreender como os professores da Educação de Jovens e Adultos (EJA se posicionavam frente ao desafio da utilização das novas tecnologias da informação e da comunicação na prática educacional, após a proposta de programa denominada “Nova EJA”, implementada pela Secretaria de Estado de Educação do Estado do Rio de Janeiro (SEEDUC. Os sete questionários foram analisados com base nos estudos do novo papel do professor de Lévy (1993, 2005 e das competências e habilidades necessárias à prática docente de Tardif (1991, 2000, 2014. Os resultados assinalaram que para além da infraestrutura necessária ao uso das tecnologias na escola, os docentes apontaram para a necessidade de construção de conhecimentos nos cursos de formação profissional inicial, sendo entendido como uma das formas de viabilizar uma atuação pedagógica que relacione positivamente educação e novas tecnologias.

  12. Uma Nova Abordagem Psicofísica na Pedagogia Teatral Contemporânea

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    Vezio Ruggieri

    2015-09-01

    Full Text Available Este artigo tem como objetivo apresentar a forma como as contribuições do modelo psicofisiológico bioexistencialista desenvolvido por Vezio Ruggieri e seus colaboradores podem trazer uma nova compreensão sobre os processos subjacentes do jogo do ator, como a presença cênica, o processo de identificação com um personagem e o mecanismo complexo da prosódia. Esse contexto teórico, que considera a conexão corpo-mente como uma relação circular, esclarece ao leitor as bases fisiológicas da percepção e da imaginação, bem como o papel fundamental que a estrutura muscular desempenha na construção desses fenômenos.

  13. Dengue e dengue hemorrágico: aspectos do manejo na unidade de terapia intensiva Dengue and dengue hemorrhagic fever: management issues in an intensive care unit

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    Sunit Singhi

    2007-05-01

    Full Text Available OBJETIVOS: Descrever a epidemiologia, as características clínicas e o tratamento do dengue e das síndromes do choque associadas ao dengue. FONTES DOS DADOS: Para esta revisão de literatura, foi feita uma pesquisa no Pubmed e nos websites da Organização Mundial da Saúde (OMS e OPAS usando os termos dengue e síndrome do choque associada ao dengue. A informação foi complementada com a experiência pessoal dos autores. SÍNTESE DOS DADOS: O dengue é a mais importante doença viral transmitida por artrópodos em seres humanos. A doença se manifesta de diversas formas, variando desde uma síndrome viral não-diferenciada até febre hemorrágica e choque grave. O dengue é uma enfermidade autolimitada, não específica, caracterizada por febre, cefaléia, mialgia, e sintomas constitucionais. As formas mais graves (febre hemorrágica e síndrome do choque podem levar a um comprometimento multissistêmico e ao óbito. O diagnóstico precoce e um acompanhamento contínuo do agravamento e da resposta ao tratamento são necessários em todos os casos. A OMS recomenda uma abordagem escalonada para o manejo, adequada para as formas mais leves e para o choque precoce. Nas formas mais graves, é preciso uma abordagem agressiva de reanimação com fluidos e de suporte à falência de órgãos em pacientes em estado crítico. As pesquisas sobre as diferenças fisiopatológicas entre o choque do dengue e o choque séptico, seleção de fluidos, agentes inotrópicos e técnicas de suporte a órgãos podem beneficiar os pacientes em estado crítico. CONCLUSÕES: Não há uma terapia específica para infecções causadas pelo dengue. Um bom tratamento de suporte pode salvar vidas mas, em última análise, as iniciativas de controle do vetor e de prevenção contra picadas do mosquito podem trazer os maiores benefícios.OBJECTIVES: To describe the epidemiology, clinical features and treatment of dengue fever and dengue shock syndrome. SOURCES: To prepare

  14. Anemia Falciforme: Um Problema Nosso. Uma abordagem bioética sobre a nova genética

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    Diniz Debora

    2003-01-01

    Full Text Available Este artigo analisa uma das ações educativas adotadas pelo Ministério da Saúde no campo das hemoglobinopatias: o folheto informativo Anemia Falciforme: Um Problema Nosso. O objetivo é discutir as premissas e os valores morais que se encontram associados a iniciativas no campo da educação genética, tendo as políticas públicas sobre anemia falciforme no Brasil como estudo de caso. A análise mostra que o conteúdo do folheto oscila entre políticas de prevenção para doenças e promoção de direitos fundamentais, uma característica da nova genética. Além disso, o excesso de informação biomédica especializada no folheto dificulta sua divulgação em massa. Os resultados encontrados foram discutidos à luz do debate bioético contemporâneo sobre a nova genética.

  15. Os Saberes tradicionais e o modo de vida camponês como elementos para a compreensão de uma nova forma de organização camponesa : o exemplo de Nova Padua/RS

    OpenAIRE

    Tiago Oliveira Nicoloso

    2006-01-01

    O presente trabalho busca analisar a importância dos saberes tradicionais e do modo de vida camponês como elementos para a compreensão de uma nova forma de organização camponesa a partir do exemplo de Nova Pádua/RS. Para tanto, é fundamental buscar no processo de colonização italiana no Rio Grande do Sul e, conseqüentemente, na história de formação de Nova Pádua, os fatores que permitem compreender os vínculos culturais com a Itália manifestos ainda hoje de forma tão intensa. Da mesma forma, ...

  16. Sistema agroflorestal em Nova Olinda, Ceará: Uma experiência de sucesso

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    Terezinha Teixeira da Silva

    2014-09-01

    Full Text Available Os Sistemas Agroflorestais foram inicialmente utilizados pelos indígenas. Atualmente são desenvolvidos principalmente nas regiões tropicais e subtropicais do planeta. No Nordeste brasileiro começaram com experiências isoladas no sertão. Apresentando resultados positivos, as experiências agroflorestais expandiram-se, ganharam importância, contribuindo para o desenvolvimento socioeconômico de algumas regiões nordestinas, a exemplo da Chapada do Araripe, no Ceará. A primeira experiência de sucesso desenvolvida nessa região foi realizada no município de Nova Olinda. Este trabalho teve como objetivo descrever a importância da implantação de um sistema agroflorestal, através de relato sobre a experiência no Sítio Taboleiro, no município de Nova Olinda, no Cariri cearense, mostrando como o SAF foi introduzido e como o Sr. Zé Arthur vê o desenvolvimento desse sistema na referida região. Utilizou-se entrevista semiestruturada com o proprietário e aplicação de questionário. A entrevista foi gravada com mp3, depois feita a transcrição e análise. Os resultados positivos apresentados pelo SAF do Sr. Zé Arthur revelam que essa prática agroecológica apresentou melhores resultados que a agricultura convencional desenvolvida em outras propriedades no município de Nova Olinda-CE. O agricultor enfatiza que os bons resultados do SAF são frutos de um investimento em mão de obra superior à agricultura convencional. Exemplo de produção sustentável, o SAF do Senhor Zé Arthur vem sendo uma das atrações do roteiro turístico do município de Nova Olinda.         Palavras-chave: Sistema Agroflorestal. Experiência de sucesso. Produção sustentável. Resultados positivos.

  17. Avaliação da coleta de sangue em papel de filtro para diagnóstico molecular da dengue

    OpenAIRE

    Célia Luiza de Lima Rodrigues

    2010-01-01

    O diagnóstico rotineiro da dengue é realizado com amostra de sangue dos casos suspeitos. A coleta tradicional de sangue (por punção venosa) é um procedimento que dificulta a realização de exames e pesquisas por ser um procedimento invasivo que nem sempre é prático para crianças e bebês, requer pessoal especializado e necessita de um local para armazenamento da amostra sob refrigeração ou congelamento. O propósito deste estudo foi coletar amostras por punção digital com uma nova tecnologia (FT...

  18. Uma nova forma de Coffea

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    C. A. Krug

    1950-01-01

    Full Text Available Nos extensos trabalhos de melhoramento do cafeeiro, há 18 anos em realização na Subdivisão de Genética do Instituto Agronômico, tem-se dedicado especial atenção à espécie C. arabica L., pelo fato de todos os nossos cafèzais pertencerem a esta espécie que, sem dúvida, fornece o produto de melhor qualidade. Nas regiões de terras extremamente cansadas, um dos principais fatôres levados em consideração no melhoramento é a rusticidade, caráter êsse, entretanto, encontrado de preferência em outras espécies, tais como o C. canephora e C. Dewevrei, cujos cafés são de má qualidade. A hibridação interespecífica, que poderia reunir em uma só planta caraterísticos de rusticidade e boa qualidade de bebida, tem o inconveniente de dar origem a plantas triplóides, que são estéreis. Daí se deduz que a obtenção artificial de formas que combinassem êsses caraterísticos constitui problema, cuja solução é extremamente demorada. No presente trabalho, apresentam-se os caracteres de uma nova forma de Coffea, encontrada em cafèzal da Fazenda Itaporã, em Terra Roxa, município de Viradouro, que, com algumas ressalvas, oferece a desejada combinação de caracteres. Trata-se, provàvelmente, de um híbrido espontâneo entre C. arabica e C. Dewevrei, com 2n = 44 cromosômios, extremamente rústico e produtivo, cujas sementes fornecem uma bebida que pode ser classificada como boa. Apenas apresenta, como principal defeito, uma auto-esterilidade quase completa. Os seus caraterísticos botânicos são descritos em detalhe. Devido ao seu porte elevado, ramos abundantes e folhas grandes e coriáceas, esse cafeeiro se assemelha ao C. Dewevrei. Os frutos são oval-elípticos, de um vermelho bem escuro quando maduros, e as sementes oblongas, constatan-do-se elevada percentagem do tipo "moca" e "chocha". Quanto à constituição citológica, as pesquisas conduziram à hipótese de este cafeeiro possuir 22 cromosômios de C. arabica e 22 (n

  19. Spectroscopy of poorly known northern dwarf novae. Part. I

    International Nuclear Information System (INIS)

    Bruch, A.

    1989-01-01

    Spectroscopic observations of 12 dwarf novae are presented most of which hitherto unknown spectroscopically. The classifications as dwarf novae could be confirmed in most cases. Two objects remain doubtful: CI UMa and MR Per. The latter has the spectrum of a very late type main sequence star with hydrogen emissions and might be a flare star showing extremely slow flares, while the CI UMa spectrum does not contain any emission line above the noise level. In two dwarf novae - DX And and NS Per - absorption lines of the secondary star are newly detected

  20. Durkheim e Weber: inspiração para uma nova sociabilidade, o neotribalismo

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    Sílvia Jurema Quaresma

    2005-01-01

    Full Text Available Este artigo tem como principal finalidade ampliar um pouco mais o conhecimento sobre o conceito de neotribalismo idealizado pelo sociólogo francês Michel Maffesoli. Este autor considera o neotribalismo como uma das características da pós-modernidade, porém estas características nos fazem retornar as idéias de Durkheim e Weber. Sendo assim, neste artigo pretendemos mostrar como Maffesoli introduz a nova concepção de sociabilidade das tribos, mas apoiada nos clássicos da Sociologia. Também expomos algumas idéias de autores como: Anthony Giddens, Boaventura de Souza Santos, Edgar Morin referentes ao paradigma da modernidade.

  1. Nova Era: uma manifestação de fé da contemporaneidade

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    Fabiano Fernandes Serrano Birchal

    2009-05-01

    Full Text Available O homem contemporâneo vive um mundo de incertezas, onde muitos dos antigos paradigmas que o senso comum considerava como absolutos se desmoronam com incrível velocidade. Esta volatilidade de sentidos é observada com ampla nitidez na busca do sagrado: as religiões tradicionais são deixadas de lado ou misturadas a práticas esotéricas, místicas e ocultas, tentativa humana de explorar o mundo através de um enfoque holístico, que reimprima na vida a magia outrora perdida. Neste contexto de construção de uma nova realidade, a percepção e manifestação do sagrado não desaparecem, mas, seguindo a mentalidade de seu tempo, transformam-se. A religiosidade assume um caráter individualista, imediatista e descompromissado, restaurando conceitos e práticas da antigüidade, em uma tentativa clara de reencantamento do mundo, agora sob a perspectiva da sociedade globalizada. Filosofias orientais invadem a dimensão religiosa do mundo ocidental, numa mistura explicitamente paradoxal. Deste epicentro nasce a cultura da Nova Era, movimento que busca restaurar a tradição sagrada do homem postulando um saber místico, pretendendo conectar o ser humano ao transcendente partindo não de instituições específicas, mas de conhecimentos e práticas do esoterismo, ocultismo e magia.Palavras-chave: Nova Era; Subjetivismo; Consumismo.ABSTRACTContemporary man lives in a world of uncertainties, where many of the old paradigms that common sense used to consider absolute are falling apart with incredible speed. Such volatility of senses is clearly noticed in the search for the sacred: traditional religions are left behind or mingled with esoteric, mystical and occult practices, in a human attempt to explore the world from a holistic viewpoint capable of rescuing life’s lost magic. In that context of construction of a new reality, the perception and manifestation of the sacred do not disappear; they rather change, following the mentality of the times

  2. Uma nova família de filtros digitais para classificação de dados com aplicações ao pré-diagnóstico de patologias na laringe

    OpenAIRE

    Luciene Cavalcanti Rodrigues

    2012-01-01

    O presente trabalho de doutorado tem por objetivo a criação de uma nova família de filtros digitais específica para o processo de classificação de dados, particularmente aplicada ao pré-diagnóstico de patologias na laringe. Antes de explicar a criação dessa nova família de filtros, foi apresentada uma breve revisão bibliográfica sobre o funcionamento do aparelho fonador humano, sobre o processo de diagnóstico de patologias e sobre a transformada discreta Wavelet, que serviu de base para a con...

  3. Aprendizagens e novas tecnologias

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    Pedro Demo

    2011-06-01

    Full Text Available Pretendo aqui, muito preliminarmente, reunir alguns argumentos favoráveis à multiplicidade de oportunidades de aprender que o aluno pode encontrar hoje em ambientes de aprendizagem mediados por novas tecnologias. Centro-me principalmente na desconstrução de algumas resistências pedagógicas (EVANS, 2001 ainda persistentes entre nós como “transmissão de conteúdos”; agarramento a uma única teoria; fixação na aula instrucionista; extirpação/endeusamento de processos avaliativos, etc. Procuro ver, em um vasto âmbito de ofertas teóricas, componentes atualmente ressaltados na discussão tecnológica em vigor, com o objetivo de indicar oportunidades de reconstrução muito aproveitável de autores e clássicos, uma vez que aprender bem não foi algo inventado pelas novas tecnologias; sempre existiu e os grandes pedagogos tiveram consciência disso, insinuando infinitas maneiras de aprender bem (DEMO, 2008. As novas tecnologias proporcionam oportunidades ainda mais ampliadas, em meio também a enormes riscos e desacertos. O que menos interessa aqui é incidir em panaceias tecnológicas, bem a gosto do consumismo neoliberal. Interessa, porém, explorar novas oportunidades de aprendizagem, bem mais centradas na atividade dos alunos, flexíveis, motivadoras e capazes de sustentar processos de autoria e autonomia.

  4. Elementos para uma nova cultura em segurança e saúde no trabalho

    OpenAIRE

    Mendes,Jussara Maria Rosa; Wünsch,Dolores Sanches

    2007-01-01

    Este artigo propõe-se a discutir o cenário contemporâneo das relações entre saúde e trabalho, apontando alguns elementos que possam contribuir para o debate sobre o tema, na perspectiva de alcançar uma nova cultura em segurança e saúde no trabalho. Evidencia-se que a predominância do viés prevencionista nesta área, que se consolidou ao longo dos anos, é resultado de um modelo hegemônico centrado no biológico e no indivíduo. A construção de práticas voltadas para a atenção à saúde do trabalhad...

  5. JOGO DA VERDADE QUÍMICO: UMA NOVA METODOLOGIA PARA O ENSINO DE TERMODINÂMICA

    Directory of Open Access Journals (Sweden)

    Nara Rúbya Sousa

    2011-02-01

    Full Text Available Com os novos avanços científicos e tecnológicos, o Ensino de Ciências, sobretudo de Química, tem sentido cada vez mais a necessidade de utilizar novas técnicas de ensino. A utilização das atividades lúdicas no ensino de ciências pode suprir estas necessidades contribuindo para uma mudança no ensino tradicional, tornando-o mais dinâmico, interativo, atrativo e interessante. Com base nisto, em nossa pesquisa, nos propomos desenvolver um jogo intitulado: Jogo Da Verdade Químico, a fim de facilitar o processo ensino-aprendizagem e avaliar o aprendizado em relação aos conceitos de Termodinâmica.

  6. Isolamento de clones com atividade lipolítica do metagenoma de solo contaminado com gordura animal e caracterização de uma nova e eficiente lipase

    OpenAIRE

    Glogauer, Arnaldo

    2012-01-01

    Resumo: Um gene de uma nova lipase foi identificado a partir de uma biblioteca metagenomica de 500.000 clones construida com a fracao majoritariamente procariotica do DNA de um solo contaminado com gordura animal, proveniente de uma estacao de tratamento de efluentes. Na triagem inicial feita em agar contendo 1% de tributirina, 2661 dos 500.000 clones da biblioteca metagenomica apresentaram atividade. Destes, 127 apresentaram atividade em agar contendo 1% de tricaprilina, enquanto que 32 se m...

  7. Etiologia de exantema em crianças em uma área endêmica de dengue Etiology of exanthema in children in a dengue endemic area

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    Delmina de S. Campagna

    2006-10-01

    Full Text Available OBJETIVO: Estudar a etiologia dos casos de exantema com ou sem febre em crianças atendidas no pronto-socorro de um hospital de uma zona endêmica para dengue. MÉTODOS: No período de 21/09/2001 a 20/09/2002, foram inscritas no estudo 95,9% (71/74 das crianças atendidas no pronto-socorro do Hospital Universitário de Campo Grande (MS que apresentassem exantema (percentual de recusa de 4,1%. Após preenchimento do protocolo com os dados das crianças, as mesmas foram submetidas a exame físico seguido da coleta de amostras de sangue para realizar hemograma com contagem de plaquetas e sorologias (IgM e IgG; inicialmente para dengue, rubéola e toxoplasmose e, posteriormente, naqueles casos com resultado negativo, realizou-se sorologia para parvovirose, herpes vírus tipo 6 e sarampo. RESULTADOS: O diagnóstico laboratorial foi confirmado através da pesquisa de anticorpo IgM em 88,7% dos casos investigados: dengue (77,5%, herpes vírus tipo 6 (8,4%, parvovirose (2,8% e diagnóstico inconclusivo em oito pacientes (11,3%. Não foi evidenciada sorologia positiva (IgM para sarampo, rubéola ou toxoplasmose naquela ocasião. As manifestações clínicas mais freqüentes nos pacientes com dengue foram: febre, prurido, prostração, mialgia e prova do laço positiva. Nos pacientes cujo diagnóstico foi dengue, a prova do laço foi positiva em 58,4% (32/55 dos casos, demonstrando diferença estatisticamente significativa quando comparada com o grupo cujo diagnóstico não foi dengue. CONCLUSÕES: Nas crianças com exantema, dengue pode ser a principal enfermidade causal, atentando-se para a epidemiologia do local. É necessário um controle constante da vigilância epidemiológica e sorológica das doenças exantemáticas.OBJECTIVE: To study the etiology of exanthema cases, with or without fever, in children seen in the emergency room of a hospital located in a region where dengue is endemic. METHODS: Enrollment took place between 21/09/2001 and 20

  8. ECONOMIA SOCIAL INCORPORATIVA (e as novas linguagens

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    Welinton dos Santos

    2017-05-01

    Full Text Available A inovação tecnológica aliada à interação de comunicação sem limites, chamada de “Economia Social Incorporativa”, sendo uma rede integrada e sociável as populações do mundo. Baseada em uma pesquisa bibliográfica de caráter qualitativo e documental mostrando que a comunicação, informações e tecnologias evoluem surgindo novos materiais em destaque o grafeno, composto por átomos de carbono com alta condutividade térmica e elétrica, flexível e resistente, material que pode substituir o silício e permitir a segunda revolução tecnológica e levando consigo a economia. Com esses feitos tecnológicos a humanidade tende a estar mais do que nunca com uma ligação inseparável das novas tecnologias que vem aparecendo de forma exponencial no mercado estimulando assim mais do que nunca a economia social. O futuro visa uma nova economia que está em transformação, provocando mudanças significativas na política econômica mundial, e por isso, todos os esforços nesta nova dinâmica de conscientização do comportamento social integrativo auxilia numa política estratégica global mais justa e igualitária.

  9. Trabalhadores dos Centros de Atenção Psicossocial de Alagoas, Brasil: interstícios de uma nova prática

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    Mara Cristina Ribeiro

    2015-03-01

    Full Text Available Os Centros de Atenção Psicossocial constituem uma das principais estratégias para a garantia de cuidados em saúde mental no enfoque da Reforma Psiquiátrica brasileira, e têm requerido considerável número de trabalhadores envolvidos em uma nova prática. Neste estudo buscou-se conhecer como se deu o processo de inserção desses trabalhadores nos serviços, e como eles se percebem e percebem suas práticas dentro do novo contexto. Trata-se de pesquisa qualitativa, na modalidade História Oral Temática, guiada por entrevistas para a produção dos dados e análise temática para a discussão dos seus resultados. Da análise, emergiram quatro categorias temáticas: inserção nos serviços; sofrimento do trabalhador; novas tecnologias de cuidado, e precariedade do trabalho. Os depoimentos apontam a necessidade do cuidado sobre o trabalhador considerando, também, suas demandas, para que esses serviços possam funcionar com toda a sua potencialidade.

  10. Dengue em três distritos sanitários de Belo Horizonte, Brasil: inquérito soroepidemiológico de base populacional, 2006 a 2007 Dengue fever in three sanitary districts in the city of Belo Horizonte, Brazil: a population-based seroepidemiological survey, 2006 to 2007

    Directory of Open Access Journals (Sweden)

    José Eduardo Marques Pessanha

    2010-04-01

    Full Text Available OBJETIVO: Determinar a soroprevalência para sorotipos virais da dengue em três distritos sanitários de Belo Horizonte e investigar a associação com variáveis de contexto e individuais. MÉTODOS: O inquérito foi conduzido nos distritos sanitários de Venda Nova, Leste e Centro-Oeste entre junho de 2006 e março de 2007. Foram incluídos todos os residentes com idade Ž 1 ano. Os participantes responderam a questionário; foi também coletada uma amostra de sangue (5 mL para determinar a presença de anticorpos contra vírus da dengue dos tipos 1, 2 e 3 por soroneutralização. O questionário abrangeu questões demográficas, posição socioeconômica, características físicas do local de moradia, mobilidade de moradia entre cidades, história pregressa de sinais e sintomas associados à dengue e conhecimento sobre medidas de prevenção da dengue, dentre outros. RESULTADOS: Entre os 709 indivíduos estudados, encontrou-se soroprevalência para dengue de 11,9% (IC95%: 9,7 a 14,6, não associada ao sexo, idade, renda familiar e mudança de município nos últimos 10 anos. Houve associação da soropositividade com tipo de moradia (apartamento ou casa/barracão, sendo apartamento fator de proteção e com índice elevado de vulnerabilidade da saúde do local de moradia. CONCLUSÃO: A soroprevalência neste estudo foi mais baixa do que a encontrada em outros inquéritos realizados em cidades brasileiras de porte grande e médio, sugerindo que Belo Horizonte tem utilizado estratégias eficazes de controle. Entretanto, foi observada uma heterogeneidade intraurbana na transmissão da dengue, em grande parte associada a indicadores contextuais de vulnerabilidade. Permanece ainda elevado o número de suscetíveis, e a dengue como questão de saúde pública de difícil controle.OBJECTIVE: To determine the seroprevalence of dengue fever serotypes in three sanitary districts in the city of Belo Horizonte and investigate the association of

  11. Uma nova espécie de Bacopa Aubl. (Scrophulariaceae da América do Sul A new species of Bacopa Aubl. [Scrophulariaceae] from South America

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    Vinicius Castro Souza

    2001-04-01

    Full Text Available Uma nova espécie de Bacopa (Scrophulariaceae do Brasil e Argentina é descrita. Ilustração e descrição desta espécie são apresentadas, além de uma comparação com espécies afins do gênero.A new species of Bacopa (Scrophulariaceae from Brazil and Argentina is described. Description and illustration are included and a comparison with related species is presented.

  12. Ensino de projeto arquitetônico com a inclusão de novas tecnologias: uma abordagem pedagógica contemporânea

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    Maycon Sedrez

    2014-09-01

    Full Text Available A adoção de novas tecnologias no processo de projeto tem desempenhado um papel fundamental na Arquitetura contemporânea. Isso tem instigado os professores a buscar conhecer os processos cognitivos envolvidos na aprendizagem de projeto. Este artigo é um estudo de caso da disciplina Responsive Architecture, lecionada pela arquiteta Anne Save de Beaurecueil na Unicamp. A disciplina inclui uma intensa utilização de meios computacionais de geração, representação e modelagem do projeto. O objetivo deste artigo é descrever o método utilizado nessa disciplina, a partir da observação das atividades, contextualizando-o no cenário das novas práticas arquitetônicas e de seu impacto no ensino, em escolas de excelência internacional. Por fim, verificam-se similaridades do método para inclusão de novas tecnologias com práticas pedagógicas atuais no ensino de Arquitetura.

  13. Explorando a Relação entre Autoeficácia e Atitude Positiva face à Introdução de uma Nova Tecnologia

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    Miguel Mauricio Isoni Filho

    2014-11-01

    Full Text Available O surgimento de novas tecnologias da informação e comunicação, como os sistemas integrados de gestão, tem influenciado não só o mundo empresarial, mas também as universidades.  Com base nisso, destaca-se que compreender os fatores que influenciam a decisão de um indivíduo em usar uma nova tecnologia vem se tornando um desafio na área de tecnologia da informação.  Em survey com 174 discentes de uma universidade federal brasileira, esta pesquisa desenvolve uma escala para associar autoeficácia e atitude positiva face à introdução do módulo de atividades acadêmicas de um sistema integrado de gestão. Entre os resultados, apresenta-se a estrutura fatorial dos construtos e discute-se a associação entre eles. As contribuições desta pesquisa são de natureza conceitual (aspectos cognitivos e atitudinais da interação pessoa-computador e metodológica (mensuração de escala. Como contribuição gerencial, a universidade poderá elaborar programas voltados a promover eficiência no uso do SIGAA com maior possibilidade de adoção por parte de seus discentes.

  14. Sobre uma nova teoria de precificação de opções e outros derivativos

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    Ailton Cassettari

    2001-09-01

    Full Text Available Este artigo desenvolve uma nova teoria de precificação de títulos derivativos, implementando-a para a situação particular de opções de compra européias de ações sem dividendos a partir da premissa básica de que o drift do ativo subjacente desempenha papel relevante no processo de precificação, no contexto dos fenômenos de transporte. É feita uma confrontação sistemática com os bem-conhecidos modelos Black-Scholes e Ornstein-Uhlenbeck bivariado que mostra a plausibilidade e efetividade desta abordagem.This paper develops a new theory of derivative securities pricing and implementes it for the specific case of European call options on a hypothetical non-dividend-paying stock. The basic premise is that the drift of the underlying asset plays a very important role in the pricing process, in the context of transport phenomena. A systematic confrontation to well-known Black-Scholes and bivariate trending Ornstein-Uhlenbeck models is also carried out, providing plausibility and effectiveness for this approach.

  15. Nova York: uma experiência de desenho dos espaços livres urbanos

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    Fany Calender

    1995-12-01

    Full Text Available O presente texto procura discutir conceitos e questões relativas ao espaço livre urbano, tendo como premissa observações de viagem recente à cidade de Nova York, onde se destaca a integração entre a intenção e a ação efetiva sobre estes espaços, em contraponto ao atual estágio da abordagem deste tema entre nós. A preocupação com o bem-estar do usuário que percorre a cidade, vi venci ando os espaços de uso coletivo em seus momentos de descanso e lazer, somada a uma política pública de incentivos, promoveu diferenciadas soluções espaciais, espalhadas por toda a região de Manhattan, culminando em um desenho da paisagem que expressa a evolução qualitativa do tratamento do espaço livre

  16. Discovery of a New Classical Nova Shell Around a Nova-like Cataclysmic Variable

    Science.gov (United States)

    Guerrero, Martín A.; Sabin, Laurence; Tovmassian, Gagik; Santamaría, Edgar; Michel, Raul; Ramos-Larios, Gerardo; Alarie, Alexandre; Morisset, Christophe; Bermúdez Bustamante, Luis C.; González, Chantal P.; Wright, Nick J.

    2018-04-01

    The morphology and optical spectrum of IPHASX J210204.7+471015, a nebula classified as a possible planetary nebula are, however, strikingly similar to those of AT Cnc, a classical nova shell around a dwarf nova. To investigate its true nature, we have obtained high-resolution narrowband [O III] and [N II] images and deep optical spectra. The nebula shows an arc of [N II]-bright knots notably enriched in nitrogen, while an [O III]-bright bow shock is progressing throughout the ISM. Diagnostic line ratios indicate that shocks are associated with the arc and bow shock. The central star of this nebula has been identified by its photometric variability. Time-resolved photometric and spectroscopic data of this source reveal a period of 4.26 hr, which is attributed to a binary system. The optical spectrum is notably similar to that of RW Sex, a cataclysmic variable star (CV) of the UX UMa nova-like (NL) type. Based on these results, we propose that IPHASX J210204.7 + 471015 is a classical nova shell observed around a CV-NL system in quiescence.

  17. Dengue in Southeast Asia: epidemiological characteristics and strategic challenges in disease prevention Dengue no Sudeste Asiático: características epidemiológicas e desafios estratégicos na prevenção da doença

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    Eng-Eong Ooi

    2009-01-01

    Full Text Available Dengue emerged as a public health burden in Southeast Asia during and following the Second World War and has become increasingly important, with progressively longer and more frequent cyclical epidemics of dengue fever/dengue hemorrhagic fever. Despite this trend, surveillance for this vector-borne viral disease remains largely passive in most Southeast Asian countries, without adequate laboratory support. We review here the factors that may have contributed to the changing epidemiology of dengue in Southeast Asia as well as challenges of disease prevention. We also discuss a regional approach to active dengue virus surveillance, focusing on urban areas where the viruses are maintained, which may be a solution to limited financial resources since most of the countries in the region have developing economies. A regional approach would also result in a greater likelihood of success in disease prevention since the large volume of human travel is a major factor contributing to the geographical spread of dengue viruses.A dengue emergiu como problema de saúde pública no Sudeste Asiático durante e após a Segunda Guerra Mundial, e vem se agravando cada vez mais, com epidemias cíclicas progressivamente mais longas e freqüentes de dengue e de febre hemorrágica da dengue. Apesar dessa tendência, a vigilância dessa virose transmitida por vetores permanece basicamente passiva na maioria dos países do Sudeste Asiático, sem apoio laboratorial adequado. O artigo apresenta uma revisão dos fatores que podem ter contribuído para a mudança no perfil epidemiológico da dengue na região, além de discutir os desafios para a prevenção da doença. Analisa-se também uma abordagem regional para a vigilância ativa dos vírus da dengue, focando as áreas urbanas onde eles se mantêm, o que pode representar uma solução à limitação de recursos financeiros, uma vez que a maioria dos pa��ses da região tem economias em desenvolvimento. Uma abordagem

  18. Guillain-Barré syndrome in the course of dengue: case report Síndrome de Guillain-Barré no curso de dengue: relato de caso

    Directory of Open Access Journals (Sweden)

    Nilse Querino Santos

    2004-03-01

    Full Text Available This case report describes the findings of a 45-year-old white woman from Brazil, who developed myalgia, fever and macular rash. She was diagnosed as having dengue, based on clinical manifestations and specific IgM titers. One week after the first symptoms of dengue, the patient developed muscle weakness, followed by tetraplegia with areflexia, and respiratory insufficiency. The electromyography had evidence of demyelinating neuropathy and the cerebrospinal fluid showed albuminocytologic dissociation. These neurologic findings were consistent with the diagnosis of Guillain-Barré syndrome. The patient was treated with immunoglobulin and metylprednisolone. Mechanical ventilation was started one week after hospital admission and maintained for four weeks. After six weeks of hospitalization the patient was discharged from the hospital on wheel chair, presenting mild muscle weakness and loss of patellar and ankle reflexes. When the patient was seen at the outpatient service three weeks after hospital discharge she was able to walk with help. This case report suggests a possible association between dengue and Guillain-Barré syndrome.Este relato de caso descreve os achados de uma mulher de 45 anos, branca, que desenvolveu mialgia, febre e eritema macular. Ela recebeu o diagnóstico de dengue, tomando por base os achados clínicos e títulos específicos de IgM. Uma semana depois do início dos primeiros sintomas de dengue, a paciente desenvolveu fraqueza muscular, tetraplegia e insuficiência respiratória. A eletromiografia mostrou evidência de uma neuropatia desmielinizante e o liquor apresentou quadro de dissociação albuminocitológica. Os achados neurológicos foram consistentes com o diagnóstico de síndrome de Guillain-Barré. A paciente foi tratada com imunoglobulina e metilprednisolona. Ventilação mecânica foi iniciada uma semana após a admissão hospitalar, sendo mantida por quatro semanas. Após seis semanas de internamento a

  19. Autopia do edifício alto" verde" e a criação de uma nova geração de ícones do desempenho ambiental

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    Erica Mitie Umakoshi

    2009-12-01

    Full Text Available A desordem urbana que tomou conta das cidades da Revolução Industrial, como Londres e Paris, no final do século 19, levou o arquiteto urbanista Le Corbusier a propor um total redesenho urbano, no qual o edifício alto seria o principal elemento de projeto. Nos anos 60, verifica-se o surgimento de projetos visionários baseados nos grandes avanços tecnológicos e voltados às questões habitacionais das grandes cidades, incluindo megaestruturas e edifícios altos. Nesse período, três grupos se destacaram no que tange às inovações do projeto de arquitetura e urbanismo: o Archigram inglês, os Metabolistas japoneses e o Grupo Francês, que criaram uma série de utopias para o tema do edifício alto. Paralelamente, a tipologia do edifício alto de escritórios crescia com o desenvolvimento econômico de importantes cidades do cenário internacional, como Nova York e Londres. À frente, diante da crise energética e ambiental dos anos 70, destacou-se uma nova preocupação na arquitetura mundial: os edifícios deveriam consumir menos energia e serem ambientalmente mais responsáveis. Com isso, surgem utopias que passam a questionar os modelos convencionais, incluindo propostas para o edifício alto" verde". Nos anos 90, o arquiteto malaio Ken Yeang se torna uma referência internacional no tema do" Edifício Alto Ecológico", cujas idéias se baseiam em uma nova estética de projeto: o intenso uso da vegetação, da iluminação e ventilação natural, dentre outras estratégias bioclimáticas, em busca do conforto ambiental. Mais recentemente, sua arquitetura foi reconhecida pelas idéias de" paisagismo vertical" e" urbanismo verde". Ao lado da utopia do edifício verde, exemplos construídos em cidades européias, desde os anos 90, clamam estar definindo as bases arquitetônicas e tecnológicas de uma nova real geração de edifícios mais ecológicos. Os projetos utópicos desenvolvidos ao longo da história vêm exercendo, no que toca

  20. Psicologia Positiva: uma nova abordagem para antigas questões

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    Simone dos Santos Paludo

    2007-04-01

    Full Text Available Historicamente, a Psicologia preocupou-se em investigar patologias, negligenciado os aspectos saudáveis dos seres humanos. Mas, a partir de 1998, assumindo a presidência da American Psychological Association, Seligman iniciou movimento denominado Psicologia Positiva, que visa oferecer nova abordagem às potencialidades e virtudes humanas, estudando as condições e processos que contribuem para a prosperidade dos indivíduos e comunidades. Este artigo apresenta e discute essa nova proposta científica, que promete melhorar a qualidade de vida dos indivíduos e prevenir patologias; também as lacunas existentes nas investigações em Ciências Humanas, as contribuições teóricas e empíricas e as possíveis aplicações desse conhecimento.

  1. GEOGRAFIA DA DENGUE: UMA ANÁLISE DAS POLÍTICAS DE CONTROLE E MONITORAMENTO DO AEDES AEGYPTI EM MANAUS/ Geography of Dengue: an analysis of the control and monitoring policies of Aedes aegypti in Manaus

    Directory of Open Access Journals (Sweden)

    Renato Ferreira de Souza

    2018-04-01

    Full Text Available Manaus apresentou uma expansão urbana impulsionada pelo advento da Zona Franca, resultando numa insuficiente infraestrutura urbana para atender o aumento populacional, atraído pelo crescimento industrial e comercial da capital amazonense, a partir da década de 1970. Dessa forma, ampliaram-se os problemas de saneamento básico, comprometendo a qualidade de vida de sua população. O controle do dengue torna-se um grande desafio, não só para os geógrafos, mas também para as políticas de controle de endemias. As zonas norte e leste de Manaus caracterizam-se por bairros mais pobres, onde degradação ambiental e desigualdades sociais ameaçam o acesso a um ambiente saudável. Infelizmente muitas pessoas não têm o cuidado de manter o ambiente limpo e livre de proliferação de mosquitos, principalmente o do vetor da dengue. Nesse sentido, é importante desenvolver um trabalho de sensibilização junto às escolas, pois as crianças e adolescentes são base para serem multiplicadores de divulgação dos cuidados necessários contra a dengue.

  2. Uma cidade pós‑criativa?

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    Malcom Miles

    2013-09-01

    Full Text Available Na década de 1990, a reabilitação urbana de base cultural tornou‑se regra na Europa, legitimada pelo conceito de cidade criativa. Em alguns casos, esse processo levou a uma marginalização de culturas locais; noutros, a esperada nova prosperidade não se concretizou com a estetização do espaço e o resultante do enobrecimento urbano (gentrification. A cidade criativa é uma cidade socialmente fragmentada na qual se valoriza a cultura entendida como as artes, em detrimento da cultura enquanto articulação de valores partilhados no quotidiano. Contudo, a crise financeira de 2008 intercetou esta trajetória, proporcionando uma oportunidade para reavaliar o conceito de cidade criativa e os seus valores implícitos. Têm aparecido alternativas, nomeadamente o movimento Ocupa e a arte ativista. Poderá existir uma cidade pós‑criativa? Poderá a imaginação criativa de uma diversidade de grupos urbanos levar a novas formações sociopolíticas e culturais? Isso constituiria possivelmente uma outra revolução urbana.

  3. Uma nova espécie de Calyptranthes (Myrtaceae da flora do Rio de Janeiro, Brasil A new species of Calyptranthes (Myrtaceae from Rio de Janeiro, Brazil

    Directory of Open Access Journals (Sweden)

    Graziela Maciel Barroso

    1996-07-01

    Full Text Available É descrita uma nova espécie para o gênero Calyptranthes (Myrtaceae, ocorrente na Reserva Biológica do Tinguá, município de Nova Iguaçu, Rio de Janeiro. Trata-se de árvore ou arvoreta do estrato intermediário ou inferior da floresta atlântica que se destaca pela pilosidade densa e rufa de seus raminhos, pecíolos e dorso foliar. Pela sua forma de crescimento com copa pequena e arredondada e beleza de seus ramos esfoliantes, a nova espécie tem aptidão ornamental como arvoreta para áreas sombreadas.Occuring on the Tinguá Biological Reserve in the municipality of Nova Iguaçu, Rio de Janeiro state, is described. It is a small tree from the intermediate or inferior layer of the Atlantic forest and is conspicuous because of the dense, reddish indumentum on its branches, petioles and lower blade surface. Due to its architectural form with small rounded canopy and the beauty of its exfoliating branches, the new species may prove useful for ornamental plantings in shady areas.

  4. (REARRANJOS DE UMA “UTOPIA DO SOM NACIONAL”: a bossa nova como realização do projeto musical modernista de Mário de Andrade(REARRANGEMENTS OF A “UTOPIA OF A NATIONAL SOUND”

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    Manoel Dourado Bastos

    2009-06-01

    Full Text Available O presente trabalho procura argumentar sobre a relação histórica entre o projeto de Mário de Andrade para a música brasileira (sua “utopia do som nacional”, segundo Arnaldo Contier e sua uma realização possível com a bossa nova. Apresenta-se em linhas gerais o referido projeto andradiano, seu caráter engajado, suas incursões na problemática do “popular” e do “erudito” e sua filiação à obsessão nacional pela formação. Expõe-se pontualmente a possível compreensão da bossa nova como um projeto modernista, sugerindo uma lógica de continuidade na experiência musical brasileira.

  5. Cronótopos de uma nação distópica: o nascimento da "dependência" no México porfiriano tardio

    OpenAIRE

    Lomnitz, Claudio

    2009-01-01

    Este artigo desenvolve uma nova abordagem sobre a antropologia e a história de fronteiras nacionais. Ele propõe uma tipologia e uma caracterização fenomenológica de duas formas de se atravessar a fronteira que surgiram paralelamente a uma nova relação de dependência econômica e política entre o México e os Estados Unidos da América no final do século XIX. Tais novas modalidades de se atravessar a fronteira envolvem o desenvolvimento de novos "cronótopos", ou seja, novas e concorrentes matrize...

  6. Dengue, geoprocessamento e indicadores socioeconômicos e ambientais: um estudo de revisão Dengue, geoprocessing, and socioeconomic and environmental indicators: a review

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    Regina Fernandes Flauzino

    2009-05-01

    Full Text Available OBJETIVO: Analisar os estudos que abordaram o tema dengue e geoprocessamento juntamente com indicadores socioeconômicos e ambientais na busca de uma melhor compreensão do comportamento da doença. MÉTODO: Conduziu-se uma busca nas bases MEDLINE, SciELO, Lilacs e banco de teses CAPES com os termos "dengue, sistema de informação geográfica, análise espacial, geoprocessamento, sensoriamento remotoe indicadores socioeconômicos e ambientais". Também foi conduzida uma busca manual de artigos selecionados das listas de referências. Foram incluídos todos os trabalhos publicados nos idiomas inglês, português ou espanhol até dezembro de 2007 que abordaram o tema dengue e geoprocessamento e indicadores socioeconômicos e ambientais. Os estudos foram agrupados conforme tipo (inquérito sorológico ou estudo com dados secundários e unidade espacial de análise (município, distritos sanitários, bairros, regiões administrativas, setores censitários e quarteirões. RESULTADOS: Foram avaliados 22 estudos, todos da América Latina (19 do Brasil. Seis eram inquéritos sorológicos e 16 utilizaram dados secundários. Sistemas de informação geográfica foram utilizados em um inquérito e em 11 estudos da outra categoria. A agregação espacial utilizada foi semelhante em ambos os tipos. A pobreza não foi fator preponderante para o risco da doença. A heterogeneidade espacial de condições de vida e incidência esteve presente em 15 dos 16 trabalhos com dados secundários. CONCLUSÕES: Como a complexidade da dengue está intimamente relacionada com as características ecológicas do ambiente, os estudos que utilizam agregados de unidades espaciais aliados à análise das características ambientais locais fornecem uma visão mais completa da doença e permitem a identificação de heterogeneidade espacial, que mostrou ser um aspecto importante para o entendimento do desenrolar da epidemia de dengue.OBJECTIVE: To further understand the disease

  7. Leptohyphidae (Insecta, Ephemeroptera do estado do Amazonas, Brasil: novos registros, nova combinação, nova espécie e chave de identificação para estágios ninfais

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    Enide Luciana Lima Belmont

    2012-09-01

    Full Text Available Leptohyphidae (Insecta, Ephemeroptera do Estado do Amazonas, Brasil: novos registros, nova combinação, nova espécie e chave de identificação para estágios ninfais. Os seguintes gêneros de Leptohyphidae ocorrem no estado do Amazonas: Amanahyphes Salles & Molineri, Leptohyphes Eaton, Tricorythodes Ulmer e Tricorythopsis Traver. A distribuição das espécies de Leptohyphidae no Estado do Amazonas é apresentada. Uma espécie nova, Tricorythodes yapekuna sp. nov., é descrita e pode ser diferenciada de outros Tricorythodes pelas (1 garras tarsais com um par de dentículos submarginais e sem dentículos marginais; (2 palpo maxilar biarticulado; (3 brânquia opercular uniformemente preta com exceção da margem apical; (4 fórmula branquial 2/3/3/3/2; e (5 margem lateral do abdome expandida nos segmentos III_VI. Uma combinação nova, Tricorythopsis rondoniensis (Dias, Cruz & Ferreira, 2009 comb. nov., é proposta e constitui o primeiro registro dessa espécie para o Estado do Amazonas. Uma chave dicotômica ilustrada para identificar ninfas de gêneros e espécies ocorrentes no Amazonas também é apresentada.

  8. Alterações hematológicas em pacientes com dengue Hematological abnormalities in patients with dengue

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    Éveny Cristine Luna de Oliveira

    2009-12-01

    Full Text Available Dengue é uma doença negligenciada de alta morbidade e mortalidade em crianças e adultos, ocorrendo principalmente em regiões tropicais e subtropicais. O objetivo desse trabalho foi avaliar as alterações hematológicas de pacientes com quadro clínico de dengue. Foram estudados 543 prontuários de atendimentos referentes à epidemia pelo vírus tipo 3, ocorrida no ano de 2007, em Campo Grande, Mato Grosso do Sul. Houve predomínio de casos de dengue clássico (90,2%, com quadro clínico leve sem complicações. As principais alterações hematológicas observadas foram a leucopenia (68,3%, plaquetopenia (66,5%, linfocitopenia (67,2% e presença de linfócitos atípicos (67%. A febre hemorrágica do dengue apresentou plaquetopenia mais prolongada e maior número de linfócitos atípicos, as demais alterações hematológicas apresentaram evolução diária semelhante às encontradas no dengue clássico. As alterações hematológicas observadas no dengue apresentaram-se de acordo com a evolução clínica e gravidade da doença.Dengue is a neglected disease with high morbidity and mortality among children and adults that occurs mainly in tropical and subtropical regions. The objective of this study was to evaluate hematological changes in patients with clinical manifestations of dengue. Medical records relating to 543 cases of dengue virus 3 that occurred during the 2007 epidemic in Campo Grande, Mato Grosso do Sul, were studied. Cases of classic dengue predominated (90.2%, with mild clinical manifestations lacking complications. The main hematological findings were leukopenia (68.3%, thrombocytopenia (66.5%, lymphocytopenia (67.2% and atypical lymphocytes (67%. In dengue hemorrhagic fever, thrombocytopenia was more prolonged and the number of atypical lymphocytes was higher, while the other hematological abnormalities presented daily evolution similar to those in classic dengue. The hematological changes observed in dengue present according

  9. DENGUE, CHIKUNGUNYA E EBOLA: VIROSES AMBIENTAIS

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    Thereza Cristina Ferreira Camello

    2014-12-01

    Full Text Available DOI: 10.12957/sustinere.2014.14122Várias viroses emergentes ou reemergentes podem ser veiculadas por mosquitos. Aedes aegypti e Aedes albopictus, os mesmos que transmitem o vírus da dengue e da febre amarela, podem disseminar o vírus Chikungunya que este ano no Brasil já fez cerca de 1000 casos confirmados. A doença tem parâmetros semelhantes aos da Dengue, e embora a taxa de letalidade seja muito baixa, sequelas podem permanecer no individuo por um ano. Em 2014 a partir de setembro o mundo observou perplexo a ressurgência de um vírus hemorrágico letal, em uma das piores epidemias já ocorridas no continente africano. O vírus Ebola atingiu mais de 6000 pessoas. Estudos no sentido de melhorar as estratégias de contenção da disseminação de vetores e dos vírus devem ser estabelecidas, enquanto aguardamos a produção de vacinas eficazes. O mundo não é imune a uma infecção endêmica, localizada no interior de um continente e não estamos preparados para atender uma demanda deste porte.

  10. Como antecipar os efeitos de uma tecnologia? Um Modelo Exploratório Inspirado na Nova Ciência de McLuhan e Aplicado ao Facebook

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    Vinícius Andrade Pereira

    2015-12-01

    Full Text Available O artigo tem como objetivo principal identificar os principais efeitos dos sites de redes sociais (SRS na cultura contemporânea, tendo como objeto específico o Facebook. Como referência teórica e metodológica adota-se uma proposição exploratória fortemente inspirada em umaNova Ciência”, tal como aventada por McLuhan. Isso implica a Lei dos Meios, sintetizada nas Tétrades. Como resultados o estudo propõe um conjunto de efeitos do Facebook na cultura contemporânea, que já podem ser identificados e mapeados e que se constituem como novos pontos e questões para futuras pesquisas. Ainda, apresenta um método de pesquisa que propõe o diálogo com disciplinas correlatas ao campo da comunicação, assim como uma metodologia flexível, capaz de lidar com descrições em profundidade de um objeto, ao mesmo tempo que acolher acasos e desvios de um procedimento científico ortodoxo, tal como preconizado por Feyerabend. Por fim, o estudo recupera uma parte importante da obra de McLuhan, ainda pouco explorada nos estudos comunacionais no Brasil.

  11. Proposta e simulação de uma arquitetura RISC

    OpenAIRE

    Fredy Joao Valente

    1991-01-01

    RISC - Uma nova tendência em arquitetura de computadores. Este trabalho apresenta um estudo de como surgiu esta nova arquitetura, e suas características básicas, que a diferencia das arquiteturas convencionais. Uma proposta de microprocessador RISC é apresentada, com sua rota de dados completamente detalhada. Um simulador para arquitetura RISC foi então construído, para se testar este microprocessador. Para validar o simulador, que é a idéia principal deste trabalho, e para se avaliar a arqui...

  12. 'Haruna': uma nova mutação somática natural da videira 'Itália' 'Haruna': a new natural somatic mutation of 'Italia' grapevine

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    Adriane Marinho de Assis

    2013-03-01

    Full Text Available O objetivo deste estudo foi descrever as principais características físico-químicas e produtivas da uva fina de mesa 'Haruna', uma nova mutação natural originada da cv. Itália, em Uraí-PR, Brasil. O formato das bagas, elipsoide alongado bastante expressivo, é uma das características que mais difere essa nova mutação da uva 'Itália'. As bagas apresentam coloração verde-clara, tendendo ao amarelo na maturação plena, com pincel e polpa verde, crocante, firme, textura carnosa e de sabor moscatel, enquanto os cachos apresentam formato cilíndrico-cônico. O ciclo, bem como o desempenho produtivo e a suscetibilidade às doenças fúngicas assemelham- se aos da cv. Itália. Durante a maturação plena, apresenta teor médio de sólidos solúveis de 16,2ºBrix, superior à 'Itália, 0,5% de ácido tartárico e índice de maturação de 31,2. Trata-se de uma nova cultivar de uva fina de mesa com bom potencial de cultivo no Brasil.The aim of this study was to describe the main physical -chemical and productive characteristics of 'Haruna' table grape, a new natural mutation originated from cv. Italia, in Uraí, PR, Brazil. The berries present a very expressive large oval shape, which is the main characteristic that differ this new mutation from 'Italia' grape. The berries color is light green, tending to yellow at full maturity, with brush and flesh green, crunchy, firm, with fleshy texture and moscatel flavor, while the clusters present cylindrical-conical shape. The cycle, as well as the production performance and the susceptibility to fungal diseases is similar to the cv. Italia. During the full maturation, it has an average content of soluble solids of 16.2ºBrix, higher than 'Italia', 0.5% of tartaric acid and maturation index of 31.2. This is a new cultivar of fine table grape with potential for cultivation in Brazil.

  13. Discussão de um sistema de custeio adaptado as exigências da nova competição global

    OpenAIRE

    Tania Henke Kraemer

    1995-01-01

    Atualmente, uma empresa deve ter sua atenção voltada não somente ao mercado brasileiro, mas também ao mercado internacional. Esta nova forma de postura, denominada “A Nova Competição Global”, vem forçando os empresários à aprimorarem, continuamente, seus processos produtivos. Nesse sentido, as novas formas de organização da produção estão revolucionando o gerenciamento das empresas. Informações geradas por relatórios econômico-financeiros são consideradas como uma das melhores formas de mediç...

  14. Uma nova espécie do gênero Temnomastax (Temnomastacinae, Eumastacidae, Orthoptera da Amazônia

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    Renan S. Olivier

    2014-12-01

    Full Text Available O gênero Temnomastax apresenta atualmente sete espécies, sendo amplamente distribuídas pelo domínio Cerrado, na América do Sul. Neste trabalho, uma oitava espécie, Temnomastax spielmanni sp. nov., é descrita para a região Amazônica brasileira. A diagnose da nova espécie baseia-se em caracteres do complexo fálico e em características morfológicas externas. Temnomastax spielmanni sp. nov. apresenta semelhança com Temnomastax beni Rehn & Rehn, 1942, que ocorre em território boliviano, mas pode ser diferenciada por alguns caracteres externos. O complexo fálico de T. spielmanni sp. nov. apresenta caracteres ainda não descritos em Temnomastacinae; tal fato reforça a necessidade da revisão taxonômica dessa subfamília, o que poderá esclarecer as relações filogenéticas existentes.

  15. PROBLEMS AS STRATEGY FOR HEALTH EDUCATION IN FINGHTING DENGUE: A REPORT OF EXPERIENCE

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    Geilsa Soraia Cavalcanti Valente

    2012-11-01

    Full Text Available Objetivo: descrever uma atividade educativa desenvolvida numa Policlínica do município de Niterói, estado do Rio de Janeiro – Brasil, junto à comunidade que freqüentava a Unidade no segundo semestre de 2011, tendo como tema: Dengue o que eu tenho com isso? Método: Trata-se de um relato de experiência descritivo, de natureza qualitativa. Resultado: O dengue constitui um grave problema de saúde pública, sendo importante ressaltar que, pela sua complexidade, a intervenção e resolução transcendem a atuação do setor saúde. Entretanto, percebe-se que as estratégias tradicionais realizadas em grande parte do país, consistem no Programa de Controle de Vetores, na eliminação dos focos de procriação do mosquito, tendo um enfoque na prevenção pela responsabilização individual dos cidadãos. Acredita-se que a atividade educativa proporcionou ir além das amarras do tradicionalismo cartesiano, permitindo uma abordagem da questão dengue que leve a uma reflexão crítica, mas que, acima de tudo, impulsione para uma mudança paradigmática de (re transformação de modelos educativos focados meramente na unicausalidade e no reducionismo.

  16. A new era for French far right politics?: Comparing the FN under two Le Pens Uma nova era para a extrema-direita francesa?: Uma comparação entre a Frente Nacional dos dois Le Pen

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    Michelle Hale Williams

    2011-10-01

    Full Text Available With 2012 elections looming on the horizon in France, much political attention has focused on the new leader of the National Front, Marine Le Pen. She is polling quite well outpacing many of her mainstream party candidate rivals for the 2012 French presidency and the public appears to have embraced her with open arms. Hailed as a promising new face of French politics, a wide swath of the French electorate indicates confidence in her ability to bring needed changes to France. Yet does she really represent a dramatic departure from former FN policies and positions? This article examines the model of the FN during the leadership of Jean-Marie Le Pen in comparison with that seen in the first eight months of Marine Le Pen’s leadership in order to address this question.Com a iminência das eleições francesas de 2012, muita da atenção política se tem centrado na nova líder da Frente Nacional, Marine Le Pen, que tem tido um desempenho notável nas sondagens, ultrapassando muitos dos seus rivais dos partidos tradicionais na corrida para a presidência francesa, e sendo aparentemente acolhida de braços abertos por grande parte do eleitorado. Considerada uma nova e promissora figura no panorama político francês, uma larga fatia do eleitorado demonstra confiança na sua capacidade para trazer ao país a mudança necessária. Mas será que ela representa, de facto, uma ruptura com as antigas posições políticas da FN? O presente artigo examina o modelo da FN sob a liderança de Jean-Marie Le Pen comparando-o com o dos primeiros oito meses da liderança de Marine Le Pen por forma a analisar esta questão.

  17. A UNIVERSIDADE DO SÉCULO XXI NECESSITA UMA MUDANÇA RADICAL. UMA PROPOSTA ESPECÍFICA: A CRIAÇÃO DOS LABORATÓRIOS DE NOVAS IDÉIAS [doi: 10.5329/RECADM.20030201005

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    José Antonio Bonilla Castillo

    2003-05-01

    Full Text Available RESUMO O artigo se divide em três partes. Na primeira, aborda-se a relação entre Universidade, empresa e sociedade, com ênfase na definição das funções e dos objetivos da Universidade, sendo que as primeiras estão constituídas pelo tripé Ensino, pesquisa e Extensão, e os segundos subdivididos em duas categorias: técnico-científicos e ético-sociais. Esses últimos são uma discussão mais pormenorizada. Na segunda parte se aborda o novo paradigma educativo, no qual a capacidade de síntese, de integração e de percepção dos padrões relativos a uma visão global dos problemas da sociedade humana é um critério fundamental. Isso é oposto à realidade atual onde prevalece uma omissão critica estimulada por um cartesianismo estreito que acaba murchando os ideais universitários. Na terceira e última parte apresenta-se uma proposta específica: a criação dos laboratórios de Novas Idéias, contendo seu objetivo básico, seus objetivos específicos, aspectos organizativos e o conteúdo programático composto por um conjunto de disciplinas (Mudança de Paradigma, Abordagem Holística, Organizações de Aprendizagem, Meio Ambiente e Desenvolvimento Sustentado; Desenvolvimento Espiritual e o Significado da Vida, etc, complementado por uma síntese final, na qual os participantes terão a responsabilidade de elaborar e desenvolver projetos específicos, em benefícios da sociedade.

  18. As novas tecnologias e o ensino da matemática

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    Rocha, Maria Lúcia

    2000-01-01

    Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Este trabalho apresenta uma análise das novas tecnologias como recurso pedagógico para o ensino de matemática. Para isso foi feito uma síntese da história da introdução dos computadores na escola, bem como os tipos de programas que os professores podem encontrar para utilizarem em suas aulas, e ainda uma síntese da informática no ensino da matemática. O trabalho também apresenta uma visão dos Parâmetros Cu...

  19. Modelo multidimensional para o controle da dengue: uma proposta com base na reprodução social e situações de riscos Multidimensional model for dengue control: a proposal based on social reproduction and risk situations

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    Solange Laurentino dos Santos

    2011-01-01

    Full Text Available O objetivo do artigo consiste em apresentar e discutir um modelo compreensivo/explicativo, de caráter ecossistêmico, sobre o processo de transmissão da dengue nos níveis de micro e macrocontexto, a partir da identificação das situações de riscos envolvidas. Considerou-se a dengue como doença infecciosa viral de transmissão vetorial que traz, na sua dinâmica de transmissão, elementos das dimensões biológicas, de conduta, ecológicas, políticas e econômicas, o que a caracteriza como um problema complexo e exige um enfoque sistêmico para seu controle. Assim, para a construção da modelagem, utilizaram-se o enfoque teórico da reprodução social de Juan Samaja e seus condicionantes de macro e microcontexto, e o enfoque operativo ecossistêmico, que buscou responder à pergunta condutora desta construção: quais são as situações de risco para transmissão da dengue, considerando as diversas dimensões da "reprodução social da saúde" no nível local? A visão ampliada das inter-relações entre as diversas situações de risco envolvidas na determinação multidimensional da dengue poderá servir como eixo direcionador para uma gestão integrada das ações do programa de controle da doença, articuladas entre os diversos setores envolvidos.This paper aims to present and discuss a comprehensive / explanatory model, of ecosystem approach, on the process of transmission of dengue in the levels of micro and macro context, from the identification of the risks involved. Dengue was considered a viral infectious disease of vectorial transmission that carries on its transmission dynamics, elements of the biological, behavioral, ecological, political and economic dimensions, that make it a complex problem and require a systemic approach to its control. Thus, for the construction of modeling, we used the theoretical framework of social reproduction of Juan Samaja and its conditions of macro and micro-context, and the operating

  20. A new species of Neosilba (Diptera, Lonchaeidae from Brazil Uma nova espécie de Neosilba (Diptera, Lonchaeidae do Brasil

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    Pedro C. Strikis

    2009-09-01

    Full Text Available A new species of Neosilba McAlpine, 1962, N. pradoi sp. nov., is described and illustrated. This new species was found in the south of Brazil (Rio Grande do Sul and Santa Catarina, in the southeast (State of São Paulo and center west (State of Mato Grosso do Sul. It has been reared from fruits of guava (Psidium guajava, Myrtaceae, "araçá" (Psidium cattleyanum, Myrtaceae, "guabiroba" (Campomanesia xanthocarpa, Myrtaceae, Surinam cherry (Malpighia emarginata, Malpighiaceae, cherry (Prunus avium, Rosaceae, orange (Citrus sinensis, Rutaceae, "ingá" (Inga laurina, Fabaceae, "esporão-de-galo" (Celtis iguanae, Ulmaceae and passion fruit (Passiflora edulis, Passifloraceae.Uma nova espécie de Neosilba McAlpine, 1962, N. pradoi sp. nov., é descrita e ilustrada. Esta nova espécie foi encontrada no sul do Brasil (Rio Grande do Sul e Santa Catarina, no sudeste (Estado de São Paulo e na região centro-oeste (Estado do Mato Grosso do Sul. Foi obtida de frutos de goiaba (Psidium guajava, Myrtaceae, araçá (Psidium cattleyanum, Myrtaceae, guabiroba (Campomanesia xanthocarpa, Myrtaceae, acerola (Malpighia emarginata, Malpighiaceae, cereja (Prunus avium, Rosaceae, laranja (Citrus sinensis, Rutaceae, ingá (Inga laurina, Fabaceae, esporão-de-galo (Celtis iguanae, Ulmaceae e maracujá (Passiflora edulis, Passifloraceae.

  1. Nova abordagem no tratamento da esquizofrenia

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    Walter Speltri

    1966-12-01

    Full Text Available Foram tratados 11 casos de esquizofrenia com a guanetidina, substância considerada, do ponto de vista farmacodinâmico, como simpaticoplégica. Na opinião do autor, os surpreendentes e significativos resultados obtidos autorizam uma nova abordagem nas pesquisas à procura da etiopatogenia da esquizofrenia e, a partir dos elementos colhidos, considera plausível uma "teoria psicossomática da esquizofrenia". Recusa-se, entretanto, a cair no atraente, mas inútil, terreno especulativo. Prefere aguardar que os farmacologistas e fisiologistas forneçam dados pais precisos sobre o mecanismo de ação da guanetidina e que novos estudos confirmem seus resultados para, depois, dar publicidade à sua teoria.

  2. Dengue Fever/Dengue Haemorrhagic Fever : Case Management

    OpenAIRE

    Nimmannitya, Suchitra

    1995-01-01

    Dengue infections caused by the four antigenically distinct dengue virus serotypes (dengue virus 1, dengue virus 2, dengue virus 3, dengue virus 4) of the family Flavivindae, are the most important arbovirus disease in man, both in terms of morbidity and mortality. The infection is transmitted from man to man by Aedes mosquitoes. Since 1956, dengue virus infection has resulted in more than 3 million hospital admissions and more than 50,000 deaths in Southeast Asia, Western Pacific countries, ...

  3. Manifestações otorrinolaringológicas em pacientes com dengue Otolaryngological manifestations of patients with dengue

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    Cristiane K. Denis

    2003-10-01

    Full Text Available O Dengue é uma doença febril aguda, causada por um arbovírus, transmitida pelo mosquito Aedes aegypti. Apresenta manifestações clássicas como febre, mialgia, epistaxe, odinofagia, vertigem e zumbido. Constitui um sério problema de saúde pública, chegando a taxas de incidência de 50 a 70% da população no Estado do Rio de Janeiro. OBJETIVO: O objetivo do nosso estudo foi avaliar pacientes com dengue, que apresentam sintomatologia otorrinolaringológica como manifestação inicial. FORMA DE ESTUDO: Coorte Longitudinal. MATERIAL E MÉTODO: Foi realizado um estudo prospectivo, incluindo 30 pacientes com dengue, com sorologia comprovada, que manifestaram queixas otorrinolaringológicas. RESULTADOS: Os sinais e sintomas foram odinofagia (60%, coriza (50%, obstrução nasal (46,6%, otalgia (36,6%, vertigem (20%, epistaxe (13,3% zumbido (6,6%, alteração de glândula salivar (6,6% e gengivorragia (3,3%. CONCLUSÃO: Na vigência de epidemias, a suspeita clínica do dengue é importante, principalmente pelas inúmeras manifestações na área de otorrinolaringologia.Dengue is an acute fever disease caused by an arbovirus, and transmitted by the mosquito Aedes aegypti. Clinical picture usually starts with classic manifestations such as fever, myalgia, epistaxis, sore throat, vertigo and tinnitus. This disease has became a serious health public problem, reaching incidence rates of 50 to 70% in Rio de Janeiro State. AIM: Our objective was to evaluate patients with dengue, presenting otolaryngological symptoms as the first clinical manifestation. STUDY DESIGN: Longitudinal Cohort. MATERIAL AND METHOD: Thirty patients with serologically confirmed Dengue were included in this prospective study. RESULTS: The most important otolaryngological signs and symptoms were sore throat (60%, hyaline rhinorrhea (50%, nasal obstruction (46.6%, earache (36.6%, vertigo (20%, epistaxis (13.3%, tinnitus (6.6%, salivary gland diseases (6.6% and bleeding gum (3

  4. The coexistence of the Escola Guaicuru – Vivendo Uma Nova Lição Program and the Secondary School Improvement and Expansion Program: (Promed/escola jovem in the State of Mato Grosso do Sul

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    Maria Dilnéia Espíndola Fernandes

    2010-12-01

    Full Text Available The present article analyzes the coexistence of the Escola Guaicuru – Vivendo Uma Nova Lição Program and the Secondary School Improvement and Expansion Program (Promed/Escola Jovem during the years 1999 to 2006. It emphasizes that, according to the Law nº. 9.424/1996 (Fundef, the state is responsible for transferring financial resources to its municipalities. As a result, the state government had to seek new sources of funding for the Secondary Education, such as the Promed, proposed and coordinated by the Ministry of Education and Culture - MEC. The research was based on the educational legislation, on federal and state government documents and on the relevant literature. It concluded that the coexistence of the Escola Guaicuru – Vivendo uma Nova Lição Program and the Promed distorted the assumptions of the state educational policy because the programs themselves had different orientations. As the state did not fully comply with the goals of the Promed, it could not receive the necessary resources to invest in the secondary school.

  5. Mitos fundadores, tradições inventadas e sentidos de cidade: uma incursão pela velha e nova Cataguases-MG

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    Wescley Silva Xavier

    2014-12-01

    uma nova cidade, distinta daquela herdada de uma economia cafeeira gerida por velhas oligarquias.

  6. PANDAS: uma nova doença? PANDAS: a new disease?

    Directory of Open Access Journals (Sweden)

    Sheila Knupp Feitosa de Oliveira

    2007-06-01

    Full Text Available OBJETIVO: Apresentar as bases diagnósticas e analisar as evidências que têm sido apontadas para a etiopatogenia, tratamento e profilaxia de PANDAS. FONTES DOS DADOS: Revisão de literatura científica através do MEDLINE no período de 1989 a 2006. SÍNTESE DOS DADOS: Os critérios diagnósticos para PANDAS foram estabelecidos há quase 10 anos, mas ainda há muita controvérsia sobre a real existência desta nova doença pediátrica. A escolha deste nome para uma nova doença, supostamente de origem pós-estreptocócica, baseia-se no acrônimo de P (pediátrico, porque ocorre em crianças, A (auto-imune, N (neuropsiquiátrico, D (doença, A (associada e S (Streptococcus. Os tiques e os sintomas obsessivo-compulsivos são as principais manifestações clínicas da doença e surgem após infecções estreptocócicas, provavelmente por mecanismos auto-imunes. Apesar de estes sintomas neuropsiquiátricos serem comuns na coréia reumática, também de etiologia pós-estreptocócica, em PANDAS faltam os movimentos clássicos da coréia e as outras manifestações de febre reumática. As possibilidades de terapia antimicrobiana e imunológica estão sendo pesquisadas e demonstram viabilidade de uso em alguns casos. CONCLUSÕES: Pesquisas ainda são necessárias para responder à pergunta-título. Enquanto isso não ocorre, a identificação de casos de tiques e transtorno obsessivo-compulsivo em crianças deve considerar a possibilidade de PANDAS, buscando a evidência de infecção estreptocócica precedendo os episódios.OBJECTIVE: To establish the diagnostic criteria for PANDAS and to analyze the existing evidence regarding its etiopathogenesis, treatment and prophylaxis. SOURCES: Review of the scientific literature through a MEDLINE search carried out between 1989 and 2006. SUMMARY OF THE FINDINGS: The diagnostic criteria for PANDAS were established nearly 10 years ago, but a lot of controversy still exists over the actual existence of this new

  7. Dengue encephalitis–A rare manifestation of dengue fever

    OpenAIRE

    Madi, Deepak; Achappa, Basavaprabhu; Ramapuram, John T; Chowta, Nityananda; Laxman, Mridula; Mahalingam, Soundarya

    2014-01-01

    The clinical spectrum of dengue fever ranges from asymptomatic infection to dengue shock syndrome. Dengue is classically considered a non-neurotropic virus. Neurological complications are not commonly seen in dengue. The neurological manifestations seen in dengue are encephalitis, meningitis, encephalopathy, stroke and Guillain-Barré syndrome. Dengue encephalitis is a rare disease. We report an interesting case of dengue encephalitis from Southern India. A 49-year-old gentleman presented with...

  8. Pesquisa de anticorpos contra arbovírus e o vírus vacinal da febre amarela em uma amostra da população de Rio Branco, antes e três meses após a vacina 17D

    Directory of Open Access Journals (Sweden)

    Tavares-Neto José

    2004-01-01

    Full Text Available Em amostra da população da cidade de Rio Branco (Acre, foi pesquisada a freqüência de portadores de anticorpos contra os arbovírus, mais prevalentes na região amazônica, e o vírus vacinal da febre amarela, antes e após a imunização com a vacina 17D. Das 390 pessoas incluídas na primeira fase do estudo (agosto de 1999, somente 190 compareceram em janeiro de 2000, três meses após a aplicação da vacina 17D (outubro de 1999. Nas amostras da primeira fase, as freqüências de soropositivos (IH para os vírus estudados foram: 17D (27,2%; Dengue-1 (0,3%; Dengue-2 (4,1%; Dengue-3 (0%; Dengue-4 (0%, entre outros 8 vírus. Nas amostras séricas de janeiro (2000, a soroconversão para o 17D foi de 89,7% (130/145 e 3,2% (6/190 passaram a ter anticorpos contra o sorotipo 3 (DEN-3. Em conclusão, por conta da elevada taxa de cobertura vacinal e de soroconversão há redução significativa do risco de urbanização do vírus da febre amarela na cidade de Rio Branco, apesar de não ser desprezível a possibilidade de uma nova epidemia de dengue, pelo DEN-3, a semelhança da registrada em 2000 e 2001 pelos sorotipos 1 e 2.

  9. UMA NOVA PRIMAVERA PARA A IGREJA

    Directory of Open Access Journals (Sweden)

    Marcelo Barros

    2003-01-01

    Full Text Available Nos últimos anos, as Igrejas cristãs vivem um tempo especial de abertura espiritual e humana. Tudo começou por um profundo diálogo com a humanidade. No caso das Igrejas evangélicas e ortodoxas, reunidas no Conselho Mundial de Igrejas, a sua assembléia geral teve como tema “Faço novas todas as coisas” (Ap 21,5. No caso da Igreja Católica, como mandou o Concílio Vaticano II, ela tem procurado renovar “até costumes veneráveis e ancestrais” para adequar-se à humanidade de hoje. Todos, tanto as pessoas favoráveis a este processo, como as que não concordam, percebem a vitalidade espiritual e o empenho com que toda a Igreja, fieís e pastores, confronta sua vida com o Evangelho de Jesus Cristo e se empenha na missão de testemunhar não a si mesma, mas o Reino de Deus. Nos meios de comunicação, entre as pessoas que são para a humanidade referência de autoridade ética e promotores de solidariedade e da paz estão muitos bispos e pastores dos países pobres do mundo.

  10. Clinodiplosis costai, uma nova espécie galhadora (Diptera, Cecidomyiidae associada com Paullinia weinmanniaefolia Mart (Sapindaceae Clinodiplosis costai, a new galler species (Diptera, Cecidomyiidae associated with Paullinia weinmanniaefolia Mart (Sapindaceae

    Directory of Open Access Journals (Sweden)

    Valéria C. Maia

    2005-09-01

    Full Text Available Clinodiplosis costai, uma nova espécie de Cecidomyiidae (Diptera que induz galhas em folhas jovens de Paullinia weinmanniaefolia é descrita (larva, macho e fêmea com base em material do Estado do Rio de Janeiro (Brasil.Clinodiplosis costai, a new species of Cecidomyiidae (Diptera that induces galls on young leaves of Paullinia weinmanniaefolia is described (larva, male and female based on material from Rio de Janeiro State (Brazil.

  11. Dengue Epidemiology

    Science.gov (United States)

    ... and dengue shock syndrome (DSS). Transmission of the Dengue Virus Dengue is transmitted between people by the ... the vectors is too infrequent to sustain transmission. Dengue is an Emerging Disease The four dengue viruses ...

  12. O rap radical e a "nova classe média"

    Directory of Open Access Journals (Sweden)

    Ricardo Indig Teperman

    2015-04-01

    Full Text Available Este artigo discute a recente alteração na posição relativa do rap e dos rappers no campo da produção cultural no Brasil. O grupo Racionais MCs, tão central no campo do rap nacional que acaba por determinar a tendência hegemônica do gênero, vem se afastando do posicionamento revolucionário que marcou seus primeiros anos. Proponho que o aumento do poder de consumo e a democratização do acesso à tecnologia e à educação são aspectos que marcam a experiência da nova geração do rap (a chamada "nova escola", personificada em Emicida, e que provocaram o reposicionamento do Racionais. Recupero uma formulação de Antonio Candido para propor que essa nova posição pode ser considerada "radical".

  13. The Shape of Long Outbursts in U Gem Type Dwarf Novae from AAVSO Data

    Science.gov (United States)

    Cannizzo, John K.

    2012-01-01

    We search the American Association of Variable Star Observers (AAVSO) archives of the two best studied dwarf novae in an attempt to find light curves for long out bursts that are extremely well-characterized. The systems are U Gem and S8 Cyg. Our goal is to search for embedded precursors such as those that have been found recently in the high fidelity Kepler data for superoutbursts of some members of the 8U UMa subclass of dwarf novae. For the vast majority of AAV80 data, the combination of low data cadence and large errors associated with individual measurements precludes one from making any strong statement about the shape of the long outbursts. However, for a small number of outbursts, extensive long term monitoring with digital photometry yields high fidelity light curves. We report the finding of embedded precursors in two of three candidate long outbursts. This reinforces van Paradijs' finding that long outbursts in dwarf novae above the period gap and superoutbursts in systems below the period gap constitute a unified class. The thermal-tidal instability to account for superoutbursts in the SU UMa stars predicts embedded precursors only for short orbital period dwarf novae, therefore the presence of embedded precursors in long orbital period systems - U Gem and SS Cyg - argues for a more general mechanism to explain long outbursts.

  14. As novas tecnologias da informação e o consumismo em saúde

    Directory of Open Access Journals (Sweden)

    Paulo Roberto Vasconcellos-Silva

    2010-08-01

    Full Text Available Uma ampliação dos conceitos de consumo tem se deslocado na direção de processos sociais até agora não contemplados por categorias tradicionais. A presente revisão analisa a aplicação dos conceitos clássicos sobre consumismo às práticas recentemente identificadas no campo da saúde, como o fenômeno da cibercondria. O desafio teórico se refere à dificuldade de extrapolação das perspectivas econômicas do consumismo às questões do auto-cuidado no contexto das tecnologias de informação e comunicação (TICs. Procura-se compreender o fenômeno da mercadorização do cuidar-de-si sob o imperativo da auto-responsabilização em saúde. São identificadas e descritas as novas identidades consumidoras em vista das inauditas questões acerca dos aprimoramentos técnicos a modificar a natureza do auto-cuidado. Conclui-se que a saúde é consumida como vitalidade decomposta em artefatos de comercializar no contexto de uma nova bioeconomia - não mais ligada à idéia de emulação e posse, e sim a novas formas de perceber-se e cuidar-se perante múltiplos riscos e novas definições do que é ser humano.

  15. Dengue em crianças: da notificação ao óbito Dengue en niños: de la notificación al óbito Dengue in children: from notification to death

    Directory of Open Access Journals (Sweden)

    Adriana Helena M. Abe

    2012-06-01

    Full Text Available OBJETIVO: Descrever aspectos históricos, epidemiológicos e clínicos da dengue em crianças, demonstrando a importância das notificações e conhecimento destas para prevenir a evolução de gravidade e os óbitos nessa população. FONTES DE DADOS: Revisão narrativa dos principais trabalhos publicados sobre dengue e dengue em crianças. Buscaram-se estudos nas seguintes bases de dados: Lilacs, SciELO, Medline e Scopus, além de documentos oficiais do Ministério da Saúde. A busca incluiu trabalhos publicados no período de janeiro de 1980 a março de 2011. Os descritores utilizados foram: dengue, dengue em criança, dengue em pediatria e notificação de doenças. SÍNTESE DOS DADOS: Todos os artigos encontrados foram avaliados e procurou-se estabelecer uma linha de tempo e principais informações alusivas ao tema, fatores referentes ao vírus e ao vetor também foram incluídos; informações sobre as características clínicas e importância das notificações foram apontadas, além da relevante investigação e elucidação de todos os óbitos notificados. Existe um grande número de estudos sobre o assunto, porém foi dada maior ênfase àqueles pertinentes às crianças. CONCLUSÕES: O conhecimento desta doença, que se configura como principal doença emergente e reemergente na atualidade, é fundamental para diagnóstico precoce, tratamento oportuno e prevenção de óbitos. Há uma lacuna na notificação adequada em Pediatria, assim como no detalhamento dos óbitos em crianças vítimas de dengue.OBJETIVO: Describir aspectos históricos, epidemiológicos y clínicos del dengue en niños, demostrando la importancia de las notificaciones y conocimiento de estas para la prevención de evolución de gravedad y óbitos en esta población. FUENTES DE DATOS: Revisión narrativa de los principales trabajos publicados sobre dengue y dengue en niños. Se buscaron estudios en las siguientes bases de datos: Lilacs, SciELO, Medline y Scopus

  16. A nova ordem repressiva

    Directory of Open Access Journals (Sweden)

    Paulo Roberto Ceccarelli

    Full Text Available Segundo o autor, a humanidade sempre foi marcada por alguma forma de controle de acordo com o discurso do momento sociohistórico que atravessa: esse texto discute alguns instrumentos de controle e repressão da contemporaneidade. Se, por séculos, foi a religião que ditou as normas sociais, na modernidade, as verdades religiosas foram substituídas por enunciados científicos que sugeriam uma linearidade histórica e propunham uma compreensão determinista do mundo, baseada na capacidade da ciência em dar respostas. As certezas da modernidade foram radicalmente questionadas na pósmodernidade, fazendo surgir outros mecanismos de controle. Para o autor, a necessidade do ser humano de criar representações e dispositivos para suportar e nomear a angústia inerente ao desamparo que lhe é próprio o leva a submeter-se aos mais variados discursos repressivos. O discurso científico atual vem sendo transformado em instrumento ideológico que, com as inúmeras expressões do politicamente correto, traduzem uma busca de normatização e de padronização de comportamentos, gerando uma nova ordem repressiva. No que diz respeito à saúde psíquica, os manuais de diagnóstico, financiados pela indústria farmacêutica, transformam comportamentos, individualidades e diversidades em patologias: as singularidades tornam-se anormalidades. Qual é o compromisso social dos psicólogos nesse debate?

  17. Por uma nova interpretação das mudanças de paradigma na administração pública

    Directory of Open Access Journals (Sweden)

    Carolina Andion

    Full Text Available O objetivo deste ensaio é identificar e aprofundar a análise dos paradigmas presentes no campo teórico da administração pública no Brasil. Além de salientar as transformações, trata-se de demonstrar a continuidade paradigmática presente nos estudos do campo em questão. A hipótese central deste texto é de que, embora tenhamos assistido a mudanças paradigmáticas nas duas últimas décadas, o campo da administração pública ainda é dominado - assim como nas ciências sociais e na teoria de organizações - por uma concepção funcionalista da ciência. Para demonstrar essa hipótese, utilizamos a seguinte metodologia para construção do argumento epistemológico e consequentemente para elaboração deste ensaio: (i Partimos de um diálogo com o trabalho de Keinert (1994, 2000, fazendo uma leitura que aponta os limites e busca complementar o mesmo; (ii examinamos criticamente a trajetória do campo da administração pública no Brasil e as diferentes correntes teóricas que o compõem, com base no modelo de paradigmas construído por Burrell e Morgan (2008; (iii analisamos então quatro correntes principais que compõem hoje o campo, as quais denominamos de Estadocêntrica; Pluralista; Nova Administração Pública e Novo Serviço Público, caracterizando cada uma delas e identificando os paradigmas nos quais elas estão ancoradas. Para concluir, apresentamos uma síntese, demonstrando o predomínio do paradigma funcionalista no campo da administração pública brasileira e chamando a atenção para a necessidade de se pensar novos caminhos metateóricos pouco explorados (CALDAS, 2007, tendo como inspiração referenciais críticos e interpretativos.

  18. A new cluster-brood building species of Plebeia (Hymenoptera, Apidae from eastern Brazil Uma nova espécie de Plebeia (Hymenoptera, Apidae do leste do Brasil, com células de cria em cacho

    Directory of Open Access Journals (Sweden)

    Gabriel A. R. Melo

    2009-01-01

    Full Text Available A new species of Plebeia, the second largest genus of stingless bees in the Neotropical region, is described from eastern Brazil. Plebeia grapiuna sp. nov., known only from the lowland forests of southern Bahia, is most similar to P. lucii Moure, a species recently described from Minas Gerais. The lack of yellow marks and the smoother integument of the frons and mesoscutum in P. grapiuna sp. nov. distinguish them. Main features of the nesting habits of the new species are described and illustrated.Uma nova espécie de Plebeia, o segundo maior gênero de meliponíneos na região Neotropical, é descrita do leste do Brasil. Plebeia grapiuna sp. nov., conhecida apenas das florestas de terras baixas do sul da Bahia, é semelhante a P. lucii Moure, uma espécie recentemente descrita de Minas Gerais. A ausência de manchas amarelas e o integumento menos rugoso da fronte e do mesoscuto em P. grapiuna sp. nov. distinguem as duas espécies. Características principais do hábito de nidificação da nova espécie são descritas e ilustradas.

  19. Uma nova proposta para o estágio de pratica de ensino em psicologia

    Directory of Open Access Journals (Sweden)

    Mary Neide Damico Figueiró

    1991-08-01

    Full Text Available The objective of this work was to propose a new alternative for the Teaching Practicum in Psychology which could provide better experiences for the licentiate student in the Educational field in terms of quality and in regards to the community needs. The methodology of this work consisted of planning, accomplishing and evaluating the extension courses and events of 20 or 30 hours taught by the licentiate students to Primary and Secondary school students, teachers of pre, school and primary school, nursery employees and the community in general. The results showed that in a significantly higher proportion the licentiate students considered, the experience in Teachining Practicum and the contribution of it to his/her professional career to be excellent. The clientele, as a whole, evaluated positively the quality of the courses and the range of the proposed objectives. It was concluded that the new alternative has brought new improvement to the Teaching Practicum, providing an integration of students of Higher Education with the primary and secondary teaching and the community in general" in favor of the knowledge democratization. O objetivo do presente trabalho foi propor uma nova alternativa para os estágios de Prática de Ensino em Psicologia que aprimorasse as experiências do licenciando no campo da Educação, dando mais qualidade a esses estágios, num vínculo com as necessidades da comunidade. A metodologia consistiu no planejamento, execução e avaliação de cursos-evento-extensão de 20 ou 30 horas pelos licenciados junto a alunos de 1° e 2° graus, professores de pré-escola e 1° grau, funcionários de creche e comunidade em geral. Quanto aos resultados, os licenciandos avaliaram, numa proporção significativamente maior, como sendo ótima a experiência em Prática de Ensino e a contribuição do estágio para a sua vida profissional. A clientela, em sua totalidade, avaliou de forma positiva a qualidade dos cursos e o alcance dos

  20. Teriparatida (PTH[1-34]rh: uma nova perspectiva no tratamento da osteoporose

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    Oliveira Juliana Helena Abreu de

    2003-01-01

    Full Text Available No momento, as medicações aprovadas para tratamento da osteoporose agem reduzindo a taxa de perda óssea e diminuindo a reabsorção óssea. A teriparatida é um fragmento recombinante sintético de 34 aminoácidos do hormônio paratireóide humano. A teriparatida se liga ao receptor de PTH da proteína G e estimula a formação e a ação dos osteoblastos, que são as células responsáveis pela formação dos ossos. Assim, a principal diferença entre o tratamento da osteoporose com teriparatida e o tratamento anti-reabsorção é que a teriparatida promove o crescimento de osso novo. Em estudos pré-clínicos, o uso intermitente de PTH foi associado com um aumento significativo da massa óssea gradeada em diversos locais. A exposição intermitente ao PTH durante 4 a 6 semanas em modelos de animais ovariectomizados leva a um aumento da espessura do osso gradeado. Há estudos clínicos que mostram que a teriparatida aumenta significativamente a densidade óssea e diminui a incidência de fraturas osteoporóticas vertebrais e não-vertebrais nas mulheres com osteoporose pós-menopáusica e têm risco alto de fratura, e aumenta a densidade óssea nos homens com osteoporose, tanto hipogonádica como idiopática. A teriparatida é dada por injeção subcutânea diária e foi associada com um mínimo de efeitos colaterais, além de não apresentar interações medicamentosas. Sendo assim, a teriparatida surge como uma abordagem completamente nova no tratamento da osteoporose, estimulando diretamente a formação do osso.

  1. Linguística de Corpus e as Novas Tecnologias de Informação e Comunicação (ICTs: uma interface necessária na formação do professor de Língua Inglesa sob uma perspectiva crítica, social e educacional

    Directory of Open Access Journals (Sweden)

    Cristina Arcuri Eluf Kindermann

    2011-02-01

    Full Text Available Este artigo visa investigar a inserção da Linguística de Corpus (LC dentro de práticas educacionais na formação de professores de Língua Inglesa em uma universidade particular de São Paulo. Objetivamos, por meio de reflexões críticas e socioculturais, estabelecer um design de interface entre a LC e as novas tecnologias de informação e comunicação (ICTs na atualidade.

  2. Time dependence of the UV resonance lines in the cataclysmic variables SU UMa, RX And and 0623+71

    International Nuclear Information System (INIS)

    Woods, J.A.; Drew, J.E.; Verbunt, Frank

    1990-01-01

    We present IUE observations of the dwarf novae SU UMa and RX And, and of the nova-like variable 0623 + 71. At the time of observation, SU UMa and RX And were in outburst. All three systems show variability in the wind-formed UV resonance lines of N v λ 1240, Si IV λ 1397 and C IV λ 1549 on timescale of hours. The amplitude of variation is smallest in RX And and largest in 0623 + 71. There is evidence that the variations observed in SU UMa's UV spectrum repeat on the orbital period. Our observations of SU UMa also reveal variability in the continuum flux during the decline from outburst maximum that is much more marked in the UV than at optical wavelengths. (author)

  3. REFLEXÕES SOBRE A AVALIAÇÃO DE DESEMPENHO: UMA BREVE ANÁLISE DO SISTEMA TRADICIONAL E DAS NOVAS PROPOSTAS

    Directory of Open Access Journals (Sweden)

    Alexandre Shigunov Neto

    2002-05-01

    Full Text Available RESUMO
    O presente trabalho teve como objetivo realizar uma análise crítica do sistema tradicional de avaliação de desempenho e das novas propostas de avaliação de desempenho. A avaliação de desempenho acompanhou a evolução das organizações e sempre esteve de alguma forma refletindo as transformações sociais. Assim, este trabalho segmentou em três fases históricas o desenvolvimento do processo de avaliação de desempenho: sistema tradicional, sistema contemporâneo e propostas para o futuro. As mudanças sociais, culturais, políticas, econômicas e tecnológicas que estão ocorrendo em grande velocidade acarretam grandes transformações organizacionais, no mercado e na crescente competitividade. Nesse sentido, as organizações necessitam descobrir e desenvolver procedimentos e maneiras que envolvam e comprometam os funcionários com seus objetivos e minimizem os equívocos e disfunções dos tradicionais métodos de avaliação. As novas propostas de avaliação de desempenho buscam incorporar conceitos modernos de gestão de recursos humanos, liderança, qualidade, valorização e crescimento do ser humano e sistemas adequados de recompensa, o que vem exigindo maior responsabilidade e preparo dos quadros avaliadores.
    Palavras-chave: funcionário, desempenho, transformações.

  4. Uma padre na aldeia global : nova evangelização e novas tecnologias de informação e comunicação

    OpenAIRE

    Aguiar, Américo Manuel Alves

    2012-01-01

    Nesta dissertação, revemos os últimos cem anos de pronunciamentos dos sucessores de Pedro, do Papa Leão XIII, ao Papa Bento XVI, atestando a atenção e interesse com que a igreja católica sempre olhou para as potencialidades oferecidas pelas novas tecnologias de informação e de comunicação. Olhamos de um ponto de vista comunicacional para a urgência da Nova Evangelização pronunciada pelo Papa João Paulo II, dando continuidade ao já expresso pelo Papa Paulo VI e pelo próprio II ...

  5. Controle do dengue em uma área urbana do Brasil: avaliação do impacto do Programa Saúde da Família com relação ao programa tradicional de controle

    Directory of Open Access Journals (Sweden)

    Francisco Chiaravalloti Neto

    2006-05-01

    Full Text Available Avaliaram-se os resultados da integração do Programa Saúde da Família (PSF e do Programa de Controle do Dengue em São José do Rio Preto, São Paulo, Brasil. O estudo foi realizado em uma área com PSF e outra sem PSF. Na primeira, os agentes comunitários de saúde, de modo integrado com as suas atribuições, orientavam os moradores sobre as medidas de controle de dengue, incentivando-os a realizá-las. Na segunda área, os agentes de controle de vetores orientavam os moradores e realizavam as atividades de controle de criadouros. Conduziram-se, de outubro de 2001 a janeiro de 2003, levantamentos para mensurar conhecimentos e práticas dos moradores sobre dengue. Na área com PSF comparativamente com a sem PSF as proporções de entrevistados que afirmaram ter como fonte de informação o serviço de saúde apresentaram aumento significante. Nas duas áreas ocorreram mudanças significantes em termos de ganhos de conhecimento e diminuição de recipientes. Os resultados mostraram que a integração entre os dois programas é viável, representa otimização de recursos ao evitar a duplicidade das visitas e possibilita um maior envolvimento da comunidade no controle do dengue.

  6. A NOVA NARRATIVA ITALIANA UM AUTOR, UM SÍMBOLO: PIER VITTORIO TONDELLI

    Directory of Open Access Journals (Sweden)

    Lucia Sgobaro Zanette

    2016-01-01

    Full Text Available Na literatura italiana dos anos oitenta, uma série de autores produziram textos classificados pela crítica de a nova narrativa italiana. Pier Vittorio Tondelli, que escreveu romances, contos, crônicas, textos críticos e peças de teatro durante toda a década, tornou-se - com as suas temáticas inerentes a uma realidade pós-moderna e, principalmente, ligadas a certas experiências da juventude do final dos anos setenta até o começo dos anos noventa - um autor-ícone desse período. Com a sua maneira de viver como homem em movimento, seu agudo senso de observa- ção, sua escritura, seu estilo, seu ritmo e seu forte sentire, ele se revelou um símbolo dessa nova geração de escritores, que promoveram uma importante renovação da literatura italiana, libertando-a dos impasses que a condicionavam: a dificuldade de leitura da narrativa neovanguardista e experimental, a falta de espessura da literatura de consumo e a obviedade da literatura realista, que, todavia, os novos escritores valorizavam bastante. Palavras-chave: literatura italiana, anos oitenta, renovação.

  7. Achados ultra-sonográficos abdominais em pacientes com dengue Abdominal ultrasound findings in patients with dengue fever

    Directory of Open Access Journals (Sweden)

    Karen Amaral do Vabo

    2004-06-01

    Full Text Available OBJETIVO: Apresentar os achados ultra-sonográficos abdominais em pacientes com dengue e compará-los aos descritos na literatura. MATERIAIS E MÉTODOS: Foram realizados exames ultra-sonográficos abdominais de 38 pacientes, 25 do sexo feminino e 13 do sexo masculino, com idade média de 35 anos, com diagnóstico de dengue sorologicamente confirmado. Os achados foram comparados com os descritos na literatura. RESULTADOS: Os achados ultra-sonográficos mais relevantes foram espessamento difuso da parede da vesícula biliar em 18 casos (47,4%, líquido livre na cavidade abdominal e/ou pélvica em 12 (31,6%, esplenomegalia em 11 (28,9%, hepatomegalia em 10 (26,3% e líquido pericolecístico em 10 (26,3%. Vinte e seis por cento dos pacientes apresentaram exames ultra-sonográficos normais. CONCLUSÃO: Os achados ultra-sonográficos abdominais são uma ferramenta adicional útil na confirmação de casos suspeitos de dengue hemorrágica e na detecção precoce da gravidade e da progressão da doença, sendo de extrema importância para o radiologista o conhecimento destes possíveis achados.OBJECTIVE: To review the abdominal ultrasound findings in patients with serologically proven dengue fever and to compare the results with data from the literature. MATERIALS AND METHODS: Thirty-eight patients with serologically proven dengue fever, 25 female and 13 male, mean age of 35 years, were submitted to abdominal ultrasound. The ultrasound findings were compared with data from the literature. RESULTS: The most relevant ultrasound findings were diffuse gallbladder wall thickening in 18 cases (47.4%, abdominal and/or pelvic free fluid in 12 (31.6%, splenomegaly in 11 (28.9%, hepatomegaly in 10 (26.3% and perivesicular fluid in 10 (26.3%. Twenty-six percent of the patients had normal abdominal ultrasound. CONCLUSION: Abdominal sonography is a useful additional diagnostic tool for the confirmation of suspected cases of dengue hemorrhagic fever and for the

  8. Dengue

    Science.gov (United States)

    Dengue is an infection caused by a virus. You can get it if an infected mosquito bites you. Dengue does not spread from person to person. It ... the world. Outbreaks occur in the rainy season. Dengue is rare in the United States. Symptoms include ...

  9. PRODUÇÃO DO ESPAÇO URBANO: NORTH SHOPPING NA DINÂMICA DE NOVAS CENTRALIDADES EM FORTALEZA- CE

    Directory of Open Access Journals (Sweden)

    Tiago Estevam Gonçalves

    2011-04-01

    Full Text Available Esta pesquisa tem como objetivo analisar a formação das novas centralidades em Fortaleza e sua relação com os shopping centers, tendo como shopping em destaque: North Shopping (inaugurado em 1991, localizado na avenida Bezerra de Menezes . No campo metodológico, realizaram-se levantamentos bibliográficos sobre a formação novas centralidades, o processo de produção do espaço urbano fortalezense incentivado pelo setor terciário e shopping center que contribuíram para o entendimento da transformação da cidade, além disso, realizamos visitamos e entrevistas no Norh Shopping. Uma das primeiras áreas centrais a se desenvolver além do Centro tradicional foi a da Aldeota incentivada pelo Center Um (instalado em 1974, na avenida Santos Dumont. Desde a formação das primeiras novas centralidades até o período atual sempre existiu uma relação intrínseca entre estas com os shoppings. Estes equipamentos modernos (shoppings aparecem com novos espaços de consumo ou novos consumos de espaço que cria e recria novas formas para atrair as pessoas ao consumo, considerando o consumir como signo de felicidade. Nesta perspectiva podemos afirmar que as atividades terciárias e os equipamentos modernos de consumo atuam no crescimento e na organização do espaço urbano, assim geram uma dinâmica comercial em Fortaleza.

  10. Ligações narrativas: o uso go link no cinema e nas novas mídias digitais

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    Egle Müller Spinelli

    2014-01-01

    Full Text Available Este artigo pretende realizar uma reflexão sobre algumas semelhanças entre a linguagem cinematográfica e as chamadas novas mídias digitais, no que diz respeito à existência de filmes que desenvolvem recursos narrativos e estéticos que funcionavam como conectores (links de outros contextos, um processo que amplia o significado da obra e é inerente às novas mídias.

  11. AT Cnc: A SECOND DWARF NOVA WITH A CLASSICAL NOVA SHELL

    International Nuclear Information System (INIS)

    Shara, Michael M.; Mizusawa, Trisha; Zurek, David; Wehinger, Peter; Martin, Christopher D.; Neill, James D.; Forster, Karl; Seibert, Mark

    2012-01-01

    We are systematically surveying all known and suspected Z Cam-type dwarf novae for classical nova shells. This survey is motivated by the discovery of the largest known classical nova shell, which surrounds the archetypal dwarf nova Z Camelopardalis. The Z Cam shell demonstrates that at least some dwarf novae must have undergone classical nova eruptions in the past, and that at least some classical novae become dwarf novae long after their nova thermonuclear outbursts, in accord with the hibernation scenario of cataclysmic binaries. Here we report the detection of a fragmented 'shell', 3 arcmin in diameter, surrounding the dwarf nova AT Cancri. This second discovery demonstrates that nova shells surrounding Z Cam-type dwarf novae cannot be very rare. The shell geometry is suggestive of bipolar, conical ejection seen nearly pole-on. A spectrum of the brightest AT Cnc shell knot is similar to that of the ejecta of the classical nova GK Per, and of Z Cam, dominated by [N II] emission. Galaxy Evolution Explorer FUV imagery reveals a similar-sized, FUV-emitting shell. We determine a distance of 460 pc to AT Cnc, and an upper limit to its ejecta mass of ∼5 × 10 –5 M ☉ , typical of classical novae.

  12. AT Cnc: A SECOND DWARF NOVA WITH A CLASSICAL NOVA SHELL

    Energy Technology Data Exchange (ETDEWEB)

    Shara, Michael M.; Mizusawa, Trisha; Zurek, David [Department of Astrophysics, American Museum of Natural History, Central Park West at 79th Street, New York, NY 10024-5192 (United States); Wehinger, Peter [Steward Observatory, the University of Arizona, 933 North Cherry Avenue, Tucson, AZ 85721 (United States); Martin, Christopher D.; Neill, James D.; Forster, Karl [Department of Physics, Math and Astronomy, California Institute of Technology, 1200 East California Boulevard, Mail Code 405-47, Pasadena, CA 91125 (United States); Seibert, Mark [Observatories of the Carnegie Institution of Washington, 813 Santa Barbara Street, Pasadena, CA 91101 (United States)

    2012-10-20

    We are systematically surveying all known and suspected Z Cam-type dwarf novae for classical nova shells. This survey is motivated by the discovery of the largest known classical nova shell, which surrounds the archetypal dwarf nova Z Camelopardalis. The Z Cam shell demonstrates that at least some dwarf novae must have undergone classical nova eruptions in the past, and that at least some classical novae become dwarf novae long after their nova thermonuclear outbursts, in accord with the hibernation scenario of cataclysmic binaries. Here we report the detection of a fragmented 'shell', 3 arcmin in diameter, surrounding the dwarf nova AT Cancri. This second discovery demonstrates that nova shells surrounding Z Cam-type dwarf novae cannot be very rare. The shell geometry is suggestive of bipolar, conical ejection seen nearly pole-on. A spectrum of the brightest AT Cnc shell knot is similar to that of the ejecta of the classical nova GK Per, and of Z Cam, dominated by [N II] emission. Galaxy Evolution Explorer FUV imagery reveals a similar-sized, FUV-emitting shell. We determine a distance of 460 pc to AT Cnc, and an upper limit to its ejecta mass of {approx}5 Multiplication-Sign 10{sup -5} M {sub Sun }, typical of classical novae.

  13. Dengue and Severe Dengue

    Science.gov (United States)

    ... all regions of WHO in recent years. Dengue virus is transmitted by female mosquitoes mainly of the species Aedes aegypti and, to a lesser extent, Ae. albopictus . This mosquito also transmits chikungunya, yellow fever and Zika infection. Dengue is widespread throughout the tropics, with ...

  14. O pensamento computacional e a formação continuada de professores: uma experiência com as TICs

    Directory of Open Access Journals (Sweden)

    Louise Alessandra Santos do Carmo Paz

    2018-03-01

    Full Text Available As novas tecnologias da informação e comunicação (TICs fazem parte do cotidiano dos alunos, mas nem sempre dos professores. Para que haja uma mudança de paradigma no papel do professor, de produtor para mediador do conhecimento é necessário o desenvolvimento de novas competências para ensinar, destacando-se o pensamento computacional. Este artigo relata a experiência de um curso de introdução às novas TICs, que foi ofertado como formação continuada para professores, utilizando uma metodologia baseada no modelo andragônico, colocando-os como colaboradores e criadores do seu saber, corresponsáveis pelos os rumos do seu processo de ensino aprendizagem.

  15. Aedes albopictus may not be vector of dengue virus in human epidemics in Brazil Aedes albopictus pode não ser vetor da dengue durante epidemias no Brasil

    Directory of Open Access Journals (Sweden)

    Nicolas Degallier

    2003-06-01

    Full Text Available Over 60,500 dengue cases were reported in the state of Espírito Santo (ES, Brazil, between 1995 and 1998. The study's purpose was to identify whether Aedes albopictus was transmitting the dengue virus during an epidemic in the locality of Vila Bethânia (Viana County,Vitória, ES. From April 3 to 9, 1998, blood and serum samples were collected daily for virus isolation and serological testing. Four autochthonous cases were confirmed through DEN 1 virus isolation and two autochthonous cases through MAC ELISA testing. Of 37 Ae. aegypti and 200 Ae. albopictus adult mosquitoes collected and inoculated, DEN1 virus was isolated only from a pool of two Ae. aegypti female mosquitoes. The study results suggest that Ae. albopictus still cannot be considered an inter-human vector in dengue epidemics in Brazil.Mais de 60.500 casos de dengue foram notificados no Espírito Santo, entre 1995 e 1998. Realizou-se estudo com o objetivo de averiguar se o mosquito Aedes albopictus estava transmitindo o vírus durante uma epidemia em Vila Bethânia (Viana, no sudeste de Vitória, capital capixaba. De 3 a 9 de abril de 1998, amostras de sangue e (ou soro de pacientes foram coletadas e os mosquitos foram capturados diariamente, tanto para isolamento viral como para testes sorológicos. Em onze casos autóctonos, quatro foram confirmados por isolamento do vírus DEN 1, e dois por reação MAC ELISA Dos 37 Ae. aegypti e 200 Ae. albopictus adultos capturados e inoculados, apenas uma amostra de vírus DEN 1 foi obtida de um lote de duas fêmeas de Ae. aegypti. Os resultados sugerem que a espécie Ae. albopictus ainda não pode ser considerada um vetor inter-humano durante epidemias de dengue no Brasil.

  16. Dengue NS1 Antigen - for Early Detection of Dengue Virus Infection

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    Amol Hartalkar

    2015-08-01

    Full Text Available Objectives: To evaluate the efficacy of NS1 antigen assay for early diagnosis of dengue virus infection in a tertiary care hospital. Methods: This cross sectional study was carried out in department of Medicine from August to December 2013. Total 100 patients with dengue fever were included. Complete blood count, alanine aminotransferase (ALT, aspartate aminotransferase (AST, Dengue NS1 antigen and IgM and IgG antibodies of dengue virus were done in all cases. Results: Of the 100 sera tested, 75% were positive for dengue virus infection based on dengue NS1 antigen, IgM antibody and IgG antibody. Dengue NS1 antigen and IgM, IgG antibody were able to detect dengue virus infection between day 1 to day 8 in 92% of samples, 86.7% of samples and 82.6% of samples respectively. Sixty nine percent (69% were found positive for dengue NS1 antigen, 65% were IgM positive and 62% were IgG positive. Based on the dengue NS1 antigen and IgM antibody combination, 74% were positive for dengue virus infections. Sensitivity of Dengue NS1 antigen was 92.3% and specificity of 74.28% in comparison to IgM antibody. Detection rate increased to 75%, based on the antigen and IgG antibody combination. Sensitivity of dengue NS1 antigen was 90.3% and specificity of 65.8% in comparison to IgG antibody. Conclusion: Dengue NS1 antigen is a useful, sensitive and specific test for early diagnosis of dengue virus infection and it improves diagnostic efficiency in combination with antibody test. Key words: Dengue fever, NS1 antigen. Introduction: Dengue fever (DF is the most common arboviral illness in humans. Each year, an estimated 50-100 million cases of dengue fever and 500,000 cases of dengue hemorrhagic fever occur worldwide, with 30000 deaths (mainly in children. Globally 2.5-3 billion people in approximately 112 tropical and subtropical countries are at risk of dengue.of samples respectively. Sixty nine percent (69% were found positive for dengue NS1 antigen, 65% were Ig

  17. Heterothalamus rupestris, espécie nova de Asteraceae do Rio Grande do Sul.

    Directory of Open Access Journals (Sweden)

    Leonardo Paz Deble

    2010-08-01

    Full Text Available Na revisão botânica do gênero Heterothalamus Less., foi descoberta uma nova espécie, endêmica da Serra do Sudeste do Rio Grande do Sul (Brasil que, a seguir, é descrita, ilustrada e comparada com sua espécie afim.

  18. China na Grande Guerra: A Conquista da Nova Identidade Internacional 10.5102/uri.v13i1.3243

    Directory of Open Access Journals (Sweden)

    Paulo Duarte

    2015-07-01

    Full Text Available A presente resenha constitui uma análise crítica à obra 'China na Grande Guerra: A Conquista da Nova Identidade Internacional', que destaca uma faceta menos conhecida de uma China que é notícia frequente devido ao sucesso do seu crescimento económico, embora passe despercebido o silêncio e humilhação por que passou, no seu percurso de construção de identidade e abertura ao mundo.

  19. Adeus à “Nova República”: esboço de mais uma via-crúcis da democracia brasileira sob o convite do Estado de exceção

    Directory of Open Access Journals (Sweden)

    Wellington Fontes Menezes

    2017-12-01

    Full Text Available Um novo momento da vida nacional brasileira se inicia com a consolidação de mais um golpe de estado após um intenso processo de articulação política de grupos de interesses para a deposição da presidenta Dilma Rousseff em agosto de 2016. Neste presente trabalho, busca-se um estudo preliminar das condições impostas por uma nova dinâmica onde a democracia foi subjugada e percebe-se a consolidação de domínio de um estado de exceção. O retorno das lições de Carl Schmitt e as considerações mais contemporâneas de Giorgio Agamben contribuem para o entendimento e formulação de um novo paradigma de atuação que não é inscrita na lei, mas está atuante dentro uma zona intermediária entre a democracia e o absolutismo.

  20. Vigilância e busca ativa de casos suspeitos de dengue hemorrágico em Ribeirão Preto, São Paulo

    Directory of Open Access Journals (Sweden)

    Pontes Ricardo José Soares

    1997-01-01

    Full Text Available Um estudo clínico-epidemiológico, do tipo relato de casos, avaliou o sistema de vigilância e busca ativa de casos suspeitos de dengue hemorrágico/síndrome de choque do dengue (DH/SCD durante uma epidemia de dengue no Município de Ribeirão Preto, Estado de São Paulo, Brasil, que ocorreu entre novembro de 1990 e março de 1991. Tratou-se da primeira epidemia de dengue registrada nessa região. Embora o dengue seja um problema de saúde pública crescente no Brasil e o DH/SCD pareça tratar-se de um problema em evolução nas Américas, os serviços de saúde pública demonstram uma atitude passiva diante da ocorrência da doença, em parte como fruto da falta de experiência. A divulgação da ocorrência desta enfermidade, tanto na forma de casos esporádicos como na forma epidêmica, é essencial para a redução da letalidade. Os dados utilizados na presente análise foram coletados pelo sistema oficial de vigilância epidemiológica do Município de Ribeirão Preto durante o período da epidemia. Entre 2 521 casos confirmados de dengue foram identificados 36 casos suspeitos de DH/SCD -- 34 casos de doença febril aguda com manifestações hemorrágicas e 2 óbitos associados ao dengue. Desse conjunto, 12 casos de dengue com manifestações hemorrágicas foram confirmados laboratorialmente. A análise dos dados clínicos, epidemiológicos, laboratoriais e de autópsia dos óbitos associados ao dengue sugeriu tratarem-se de casos de DH/SCD primário. O estudo aqui descrito evidenciou a dificuldade do sistema assistencial de saúde em estabelecer a suspeita clínica de DH/SCD. Isto acarretou demora e inadequação na conduta clínica. Além disso, ficou confirmada a necessidade de um sistema de vigilância epidemiológica ativa permanente, que possibilite a identificação precoce dos casos suspeitos de DH/SCD e viabilize uma ação de controle rápida e adequada.

  1. PERSONAL EDUCADOR – UMA NOVA ESTRATÉGIA DO CAPITAL DE “EDUCAÇÃO” PARA O TRABALHO

    Directory of Open Access Journals (Sweden)

    Lydia Maria Pinto Brito

    2017-03-01

    Full Text Available Com a reestruturação do capital e a emergência de novos modelos de gestão do trabalho, a educação corporativa passou a ser uma das pautas mais importantes das organizações. O presente ensaio teórico tem como objetivo apresentar alguns elementos para reflexão sobre os programas de educação corporativa individualizada, ou seja, os programas de: “coaching” e “mentoring”, que aliados aos times de aprendizagem e as universidades corporativas vem suprir a necessidade do capital de promover um aprendizado permanente direcionado pelas necessidades específicas de cada empresa. Tem como referencial de análise Mészáros (2005. Verifica-se que a literatura produzida pela Administração sobre o assunto em  questão contém um discurso alinhado com o argumento da necessidade de desenvolvimento de lideranças educadoras na atualidade. Indica a apropriação pela empresa, através da mão-de-obra mais nova e consequentemente mais barata, do saber do trabalhador mais antigo e experiente, detentor do saber tácito da organização, que fica vulnerável ao processo de exclusão.

  2. Educação tecnológica: uma nova perspectiva pedagógica

    Directory of Open Access Journals (Sweden)

    Rotta, Mariza

    2012-09-01

    Full Text Available RESUMO: Identificar no contexto escolar a percepção docente de como estão sendo utilizadas às novas tecnologias, discutindo a inclusão da informática na educação, com ênfase aos aspectos de mediação que professores e gestores fazem desses recursos disponíveis, ou seja, de como o conhecimento é tratado em um recurso didático-pedagógico via computador ou outro recurso. Para demonstrar essa relevância os dados levantados por meio da pesquisa aplicada aos professores, gestores e responsáveis da Secretaria Municipal de Educação e Núcleo Regional de Educação, do Município de Dois Vizinhos – Paraná, Brasil, serviu de apoio para a análise e reflexão sobre questões relativas à utilização destes recursos educativos, demonstrado a importância desses no meio educativo e na sociedade a partir de uma nova concepção pedagógica e metodológica, tendo em vista a ampliação desta discussão, nas novas relações de conhecimento, cultura, tecnologia e sociedade, como forma de instrumentalização para inovação na aprendizagem.Resumen: Este artículo procura identificar en el contexto escolar la percepción docente sobre cómo están siendo utilizadas las nuevas tecnologías, discutiendo la inclusión de la informática en la educación, con énfasis en los aspectos de mediación que docentes y gestores hacen de estos recursos disponibles, o sea, sobre cómo el conocimiento es tratado en un recurso didáctico-pedagógico vía computadora u otro recurso. Para demostrar esa relevancia, los datos recolectados, por medio de una investigación tipo exploratoria, aplicada a los maestros, gestores y responsables de la Secretaría Municipal de Educación y Núcleo Regional de Educación, del Municipio de Dos Vecinos-Paraná, Brasil, sirvió de apoyo para el análisis y la ponderación sobre cuestiones relativas a la utilización de estos recursos educativos, se demuestra la importancia de estos en el medio educativo y en la sociedad

  3. Dengue in children.

    Science.gov (United States)

    Verhagen, Lilly M; de Groot, Ronald

    2014-11-01

    Dengue is a mosquito-borne viral disease of expanding geographical range and increasing incidence. The vast majority of dengue cases are children less than 15 years of age. Dengue causes a spectrum of illness from mild fever to severe disease with plasma leakage and shock. Infants and children with secondary heterologous dengue infections are most at risk for severe dengue disease. Laboratory diagnosis of dengue can be established within five days of disease onset by direct detection of viral components in serum. After day five, serologic diagnosis provides indirect evidence of dengue. Currently, no effective antiviral agents are available to treat dengue infection. Therefore, treatment remains supportive, with emphasis on close hematological monitoring, recognition of warning signs of severe disease and fluid-replacement therapy and/or blood transfusions when required. Development of a dengue vaccine is considered a high public health priority. A safe and efficacious dengue vaccine would also be important for travelers. This review highlights the current understanding of dengue in children, including its clinical manifestations, pathogenesis, diagnostic tests, management and prevention. Copyright © 2014 The British Infection Association. Published by Elsevier Ltd. All rights reserved.

  4. Internet e livro: uma falsa dicotomia

    Directory of Open Access Journals (Sweden)

    Dulce Maria Baptista

    2012-02-01

    Full Text Available A partir da agilização das rotinas burocráticas de empresas e de instituições governamentais possibilitada pelo advento do computador e da internet, analisa-se a influência das novas tecnologias no mundo do livro, da leitura e das bibliotecas. Diferentes autores sugerem que, ao invés de uma simples substituição do livro pela internet, há uma tendência no sentido da coexistência e da convergência dessas mídias. A preservação da fonte primária ganha relevância no ambiente da informação eletrônica.

  5. O uso de Charges como instrumento para identificação de concepções individuais e representações sociais sobre a Dengue

    Directory of Open Access Journals (Sweden)

    Camila Brito Galvão

    2015-05-01

    Full Text Available A dengue é hoje uma das doenças com maior incidência no Brasil, com especial frequência no município de Fênix –Paraná. No presente estudo pretendeu-se analisar as concepções que as crianças têm sobre a dengue, identificando os componentes do modelo KVP, bem como conhecer as representações sociais deste grupo. Para o efeito optou-se pela utilização de charges com alunos do 5º ano do ensino fundamental de uma escola localizada no município de Fênix, cujos textos foram analisados para identificação de categorias e dos componentes do modelo KVP (conhecimentos, valores e práticas a elas associadas. Foram identificadas quatro categorias de respostas sobre a interpretação da charge relativa à dengue: (i prevenção da dengue, (ii perigoso que pode levar à morte, (iii problema de saúde pública e (iv combater a dengue. Verificou-se que a “prevenção da dengue” foi a categoria em que se identificaram os três domínios K, V e P implicados na construção das concepções, enquanto as duas categorias “perigoso que pode levar à morte” e “problema de saúde pública” apresentaram apenas os domínios K e V, e a categoria “combater a dengue” apenas evidenciou o domínio V. Os resultados do estudo mostraram que os alunos já veem a dengue como um problema com consequências sérias e que todos têm sua responsabilidade no controle da doença. Percebe-se, portanto, que todo o trabalho que vem sendo realizado pela secretaria de saúde, pelas escolas ou campanhas publicitárias esta surtindo efeito, uma vez que no ano de 2014 houve uma redução do número de casos no município foco da pesquisa.The use of Charges as an instrument to identify individual conceptions and social representations about DengueAbstract Nowadays dengue is one of the diseases with the highest incidence in Brazil, with particular frequency in the municipality of Phoenix-Paraná. The present study aims to analyze the concepts that children have

  6. Dengue viral infections

    OpenAIRE

    Malavige, G; Fernando, S; Fernando, D; Seneviratne, S

    2004-01-01

    Dengue viral infections are one of the most important mosquito borne diseases in the world. They may be asymptomatic or may give rise to undifferentiated fever, dengue fever, dengue haemorrhagic fever (DHF), or dengue shock syndrome. Annually, 100 million cases of dengue fever and half a million cases of DHF occur worldwide. Ninety percent of DHF subjects are children less than 15 years of age. At present, dengue is endemic in 112 countries in the world. No vaccine is available for preventing...

  7. Tetravalent Dengue Vaccine: A Review in the Prevention of Dengue Disease.

    Science.gov (United States)

    Scott, Lesley J

    2016-09-01

    Tetravalent, live-attenuated, dengue vaccine (Dengvaxia(®); CYD-TDV) is the first vaccine approved for the prevention of dengue disease caused by dengue virus (DENV) serotypes 1-4 in individuals aged 9-45 or 9-60 years living in high dengue endemic areas. This narrative review discusses the immunogenicity, protective efficacy, reactogenicity and safety of CYD-TDV in the prevention of dengue disease. In Latin American and Asian phase 3 trials in children and adolescents (n > 30,000), the recommended three-dose CYD-TDV regimen was efficacious in preventing virologically-confirmed dengue (VCD) during the period from 28 days after the last dose (month 13) to month 25, meeting the primary endpoint criteria. Protective efficacy against VCD in the respective individual trials was 60.8 and 56.5 % (primary analysis). During the 25-month active surveillance phase, CYD-TDV also provided protective efficacy against VCD, severe dengue, any grade of dengue haemorrhagic fever and VCD-related hospitalization in children aged 9 years and older. CYD-TDV was generally well tolerated, with no safety concerns identified after up to 4 years' follow-up (i.e. from post dose 1) in ongoing long-term studies. Based on evidence from the dengue clinical trial program, the WHO SAGE recommended that countries with high dengue endemicity consider introducing CYD-TDV as part of an integrated disease prevention strategy to lower disease burden. Pharmacoeconomic considerations will be pivotal to implementing dengue vaccination prevention strategies in these countries. The availability of a dengue vaccine is considered essential if the 2012 WHO global strategy targets for reducing the burden of dengue disease by 2020 are to be attained. Hence, CYD-TDV represents a major advance for the prevention of dengue disease in high dengue endemic regions.

  8. Insuficiência cardíaca com fração de ejeção preservada: combater equívocos para uma nova abordagem

    Directory of Open Access Journals (Sweden)

    Ricardo Fontes-Carvalho

    2011-06-01

    Full Text Available Durante as últimas décadas, a insuficiência cardíaca com fração de ejeção preservada (ICFEP foi alvo de menor atenção por parte das comunidades médica e científica, o que levou ao aparecimento de um conjunto de equívocos relativamente às suas características, diagnóstico e abordagem terapêutica. Nos últimos anos surgiram novos estudos que alteraram os conceitos classicamente associados à ICFEP, contribuindo para uma nova visão dessa doença. Com esta revisão pretendemos abordar as mais recentes evidências existentes na área da ICFEP e combater os principais equívocos a ela associados, de forma a melhorar a sua abordagem diagnóstica e terapêutica. Temos hoje vários dados que demonstram que a ICFEP é uma entidade que necessita de uma abordagem clínica distinta da utilizada na insuficiência cardíaca sistólica (ICS. A ICFEP deixou de ser vista como uma doença "benigna", porque está associada a um mau prognóstico e a uma elevada prevalência. A sua fisiopatologia é complexa, não está totalmente esclarecida e, para além da disfunção diastólica, foram recentemente descobertos outros fatores, cardíacos e extracardíacos, que estão também implicados no seu aparecimento. Dispomos hoje de critérios objetivos para o seu diagnóstico, sobretudo recorrendo aos novos parâmetros ecocardiográficos de avaliação da função diastólica, nomeadamente ao cálculo da relação E/e' obtida por meio do Doppler tecidual. Finalmente, o tratamento da ICFEP continua a ser uma incógnita, porque não dispomos atualmente de nenhuma estratégia terapêutica capaz de alterar o prognóstico da ICFEP. Desse modo, abordaremos também os potenciais novos alvos terapêuticos que poderão revolucionar o tratamento futuro da ICFEP.

  9. NOVAS TECNOLOGIAS NO ENVELHECIMENTO

    Directory of Open Access Journals (Sweden)

    Rosa Maria Farah

    2010-02-01

    Full Text Available O Programa de Estudos Pós-Graduados em Gerontologia/PUC-SP desenvolve pesquisas em diversificadas linhas algumas das quais têm em comum o acolhimento à questão das novas tecnologias no envelhecimento. São investigações de caráter interdisciplinar que envolvem docentes-pesquisadores, orientandos de mestrado e de iniciação científica. Na área da educação a distância, a PUC-SP inaugura um trabalho em que o idoso interessado em avançar em seus conhecimentos é recebido em um ambiente virtual de aprendizagem, em que pode participar de cursos avançados de aquisição de novas linguagens e de navegação na Internet, cujas consequências são o investimento em uma via mais digna para o envelhecer no sentido de esse idoso sentir-se um ser ligado aos novos tempos em que a interatividade digital traz-lhe possibilidades ilimitadas de contatos com o outro, com o mundo enfim. A pesquisa sobre a inclusão cibersocial do idoso mostra o que significa colocar o idoso em contato com a Internet, quando este recebe, por meio das redes sociais, ofertas de várias ordens, e equipamentos que contornam limitações de ordem física ou motora. Além disso, o registro digital da memória do idoso, de sua história e referências também podem constituir conteudos preciosos para pesquisas. A relação do idoso com a informática pode situá-lo como um ator, produtor e reprodutor no ciberespaço. Isso significa que as vantagens do uso do computador fazem o idoso ganhar novo sentido na vida, na medida em que pode assim preencher o vazio causado pelas perdas que lhe vão ocorrendo, possibilitando que ele redimensione seu olhar para o presente e futuro. Palavras-chave: o sujeito-idoso nas novas tecnologias; novas tecnologias e envelhecimento; o idoso na educação a distância; internet na velhice.

  10. DenguePredict: An Integrated Drug Repositioning Approach towards Drug Discovery for Dengue.

    Science.gov (United States)

    Wang, QuanQiu; Xu, Rong

    2015-01-01

    Dengue is a viral disease of expanding global incidence without cures. Here we present a drug repositioning system (DenguePredict) leveraging upon a unique drug treatment database and vast amounts of disease- and drug-related data. We first constructed a large-scale genetic disease network with enriched dengue genetics data curated from biomedical literature. We applied a network-based ranking algorithm to find dengue-related diseases from the disease network. We then developed a novel algorithm to prioritize FDA-approved drugs from dengue-related diseases to treat dengue. When tested in a de-novo validation setting, DenguePredict found the only two drugs tested in clinical trials for treating dengue and ranked them highly: chloroquine ranked at top 0.96% and ivermectin at top 22.75%. We showed that drugs targeting immune systems and arachidonic acid metabolism-related apoptotic pathways might represent innovative drugs to treat dengue. In summary, DenguePredict, by combining comprehensive disease- and drug-related data and novel algorithms, may greatly facilitate drug discovery for dengue.

  11. Dengue-associated kidney disease.

    Science.gov (United States)

    Lizarraga, Karlo J; Nayer, Ali

    2014-01-01

    A mosquito-borne viral illness highly prevalent in the tropics and subtropics, dengue is considered a major global health threat by the World Health Organization. Directory of Open Access Journals (DOAJ), Google Scholar, PubMed (NLM), LISTA (EBSCO) and Web of Science have been searched. An RNA virus from the genus Flavivirus, dengue virus is transmitted by Aedes aegypti,the yellow fever mosquito. Dengue is asymptomatic in as many as one half of infected individuals. Dengue fever is an acute febrile illness accompanied by constitutional symptoms. Dengue hemorrhagic fever and dengue shock syndrome are the severe forms of dengue infection.Dengue infection has been associated with a variety of renal disorders. Acute renal failure is a potential complication of severe dengue infection and is typically associated with hypotension, rhabdomyolysis, or hemolysis. Acute renal failure complicates severe dengue infection in 2-5% of the cases and carries a high mortality rate. Proteinuria has been detected in as high as 74% of patients with severe dengue infection. Hematuria has been reported in up to 12.5% of patients. Various types of glomerulonephritis have been reported during or shortly after dengue infection in humans and mouse models of dengue infection. Mesangial proliferation and immune complex deposition are the dominant histologic features of dengue-associated glomerulonephritis. On a rare occasion, dengue infection is associated with systemic autoimmune disorders involving the kidneys. In the vast majority of cases, dengue infection and associated renal disorders are self-limited.

  12. Nova diagnostics summary

    International Nuclear Information System (INIS)

    Slivinsky, V.W.; Drake, R.P.

    1985-01-01

    The authors intend that Nova be the best diagnosed ICF research facility in operation today. The authors experience in providing advanced diagnostics for previous laser systems will be extended at Nova, and will be challenged by the development of new instrumentation to diagnose the more advanced targets made possible by this powerful laser. Previous experience has shown that to understand target performance, the authors must have as complete a set of diagnostics as possible. The Nova diagnostics are divided into two sets: the basic set required for the initial Nova experiments and the more advanced set for later, generally more complex, experiments. The basic set will be operational for the first Nova shots; it was a Nova line item funded with Nova construction money. This basic set is presented in a table

  13. Docinhos e ensaios de não inferioridade: uma experiência pedagógica criativa

    Directory of Open Access Journals (Sweden)

    David William Moraes

    Full Text Available Os novos desafios na área da educação surgem com o próprio desenvolvimento do conhecimento. Novas técnicas de pesquisa possibilitaram grandes descobertas na ciência e, com isso, uma crescente complexificação dos temas estudados. Os alunos, inseridos no universo dinâmico da internet, também evoluíram e não se encaixam mais nas prescrições da pedagogia tradicional. Para essas novas realidades, a forma de educar no século XXI exige dos educadores um esforço de criatividade para transmitir um conhecimento cada vez mais complexo. Para ilustrar essa nova situação, relatamos uma experiência pedagógica que buscou, com a criatividade de uma intervenção fictícia, favorecer o ensino dos ensaios clínicos de não inferioridade. A experiência demonstra a utilidade de tais ensaios clínicos quando se necessita testar a eficácia de tratamentos. A utilização dos docinhos e a participação dos alunos como sujeitos do ensaio configuraram-se como uma metodologia ativa, de aproximação entre os educandos e seu objeto de estudo. O exercício realizado está de acordo com os modelos pedagógicos sugeridos pela teoria da aprendizagem significativa e pode servir de referência para iniciativas semelhantes.

  14. A new species of the fungus-farming ant genus Mycetagroicus Brandão & Mayhé-Nunes (Hymenoptera, Formicidae, Attini Uma nova espécie de formiga cultivadora de fungo, do gênero Mycetagroicus Brandão & Mayhé-Nunes (Hymenoptera, Formicidae, Attini

    Directory of Open Access Journals (Sweden)

    Carlos Roberto Ferreira Brandão

    2008-09-01

    Full Text Available The fungus-farming ant genus Mycetagroicus Brandão & Mayhé-Nunes was proposed based on three species from the Brazilian "Cerrado": M. cerradensis, M. triangularis and M. urbanus. Here we describe a new species of Attini ant of the genus Mycetagroicus, M. inflatus n. sp., based on two workers collected in eastern Pará State, Brazil. A new key for species identification, comments on differences among species and new geographical distribution data are furnished.O gênero de formigas cultivadoras de fungos, Mycetagroicus Brandão & Mayhé-Nunes, foi proposto com base em três espécies do Cerrado: M. cerradensis, M. triangularis e M. urbanus. Neste trabalho descrevemos uma nova espécie de Attini do gênero Mycetagroicus, M. inflatus n. sp., baseada em duas operárias coletadas no leste do Pará, Brasil. Apresentamos uma nova chave para a identificação das espécies, comentários sobre as diferenças entre as espécies e novos dados sobre a distribuição geográfica.

  15. Anemia Falciforme: Um Problema Nosso. Uma abordagem bioética sobre a nova genética Sickle Cell Anaemia: A Brazilian Problem.A bioethical approach to the new genetics

    Directory of Open Access Journals (Sweden)

    Debora Diniz

    2003-12-01

    Full Text Available Este artigo analisa uma das ações educativas adotadas pelo Ministério da Saúde no campo das hemoglobinopatias: o folheto informativo Anemia Falciforme: Um Problema Nosso. O objetivo é discutir as premissas e os valores morais que se encontram associados a iniciativas no campo da educação genética, tendo as políticas públicas sobre anemia falciforme no Brasil como estudo de caso. A análise mostra que o conteúdo do folheto oscila entre políticas de prevenção para doenças e promoção de direitos fundamentais, uma característica da nova genética. Além disso, o excesso de informação biomédica especializada no folheto dificulta sua divulgação em massa. Os resultados encontrados foram discutidos à luz do debate bioético contemporâneo sobre a nova genética.This article analyzes one of the educational initiatives of the Brazilian Ministry of Health on hemoglobinopathies: the leaflet entitled Sickle Cell Anaemia: A Brazilian Problem. The purpose is to discuss the moral values associated with initiatives in genetics education, and the case study focuses on public policies related to sickle cell anaemia in Brazil. The analysis shows that the topics in the leaflets fluctuate between disease prevention policies and human rights protection, a basic characteristic of the new genetics. In addition, the leaflet’s excessive biomedical information hinders understanding by lay readers. The results are analyzed in the light of the contemporary bioethical debate on the new genetics.

  16. Uma nova heurística para o problema de minimização de trocas de ferramentas A new heuristic for the minimization of tool switches problem

    Directory of Open Access Journals (Sweden)

    Antônio Augusto Chaves

    2012-01-01

    Full Text Available O problema de minimização de troca de ferramentas (MTSP busca uma sequência de processamento de um conjunto de tarefas, de modo a minimizar o número de trocas de ferramentas requeridas. Este trabalho apresenta uma nova heurística para o MTSP, capaz de produzir bons limitantes superiores para um algoritmo enumerativo. Esta heurística possui duas fases: uma fase construtiva que é baseada em um grafo em que os vértices correspondem a ferramentas e existe um arco k = (i, j que liga os vértices i e j se e somente se as ferramentas i e j são necessárias para a execução de alguma tarefa k; e uma fase de refinamento baseada na meta-heurística Busca Local Iterativa. Resultados computacionais mostram que a heurística proposta tem um bom desempenho para os problemas testados, contribuindo para uma redução significativa no número de nós gerados de um algoritmo enumerativo.The minimization of tool switches problem (MTSP seeks a sequence to process a set of jobs so that the number of tool switches required is minimized. This study presents a new heuristic for the MTSP. This heuristic has two phases: a constructive phase, based on a graph where the vertices correspond to tools and there is an arc k = (i, j linking vertices i and j if and only if the tools i and j are required to execute some job; and an improvement phase, based on an Iterated Local Search. Computational results show that the proposed heuristic has a good performance on the instances tested contributing to a significant reduction in the number of nodes generated by an enumerative algorithm.

  17. A Estratégia em Relacionamentos Coopetitivos: um estudo do arranjo produtivo de Nova SerranaStrategy and Coopetitive Relationships: the case of Nova Serrana clusterLa Estrategia en las Relaciones Coopetitivas: el caso del cluster de Nova Serrana

    Directory of Open Access Journals (Sweden)

    LEITE, Ramon Silva

    2009-03-01

    Full Text Available RESUMOTradicionalmente, a literatura gerencial aborda os efeitos de relacionamentos competitivos ou colaborativos na estratégia organizacional. Entretanto, recentemente, verifica-se o crescimento de uma terceira abordagem, na qual um mesmo relacionamento pode integrar rivalidade e parceria entre concorrentes. Este estudo tem por finalidade fornecer subsídios para essa discussão. Para isso, foi adotado um delineamento qualitativo de pesquisa, no qual foram entrevistados os empresários do arranjo produtivo calçadista de Nova Serrana. Com isso, foram identificados os aspectos que levam as empresas da cidade a adotarem uma postura colaborativa ou competitiva em seus relacionamentos.ABSTRACTTraditionally, the management literature discusses the effects of competitive or collaborative relationships in organizational strategy. However, recently a third approach has emerged, in which a single relationship is seem as a variable that can integrate collaboration and rivalry between competitors. This study aims to provide subsidies for this discussion. For this, a qualitative design was adopted; in which businessmen of the city of Nova Serrana were interviewed. The results indicate that the decision of collaborate or compete is dependent on a set of factors.RESUMENTradicionalmente, la literatura de gestión la analiza los efectos de la competencia o de relaciones de colaboración en las estrategias de la organización. Sin embargo, recientemente, un tercer enfoque ha surgido, en el que una sola relación se parece como una variable que puede integrar la colaboración y la rivalidad entre competidores. Este estudio tiene como objetivo proporcionar subsidios para este debate. Por ello, se adoptó un diseño cualitativo en el que los hombres de negocios de la ciudad de Nova Serrana fueron entrevistados. Los resultados indican que la decisión de colaborar o competir depende de una serie de factores.

  18. Introducing dengue vaccine: Implications for diagnosis in dengue vaccinated subjects.

    Science.gov (United States)

    Alagarasu, Kalichamy

    2016-05-27

    Diagnosis of dengue virus infections is complicated by preference for different diagnostic tests in different post onset days of illness and the presence of multiple serotypes leading to secondary and tertiary infections. The sensitivity of the most commonly employed diagnostic assays such as anti dengue IgM capture (MAC) ELISA and non structural protein (NS) 1 capture ELISA are lower in secondary and subsequent infections. Introduction of dengue vaccine in endemic regions will affect the way how dengue is diagnosed in vaccinated subjects. This viewpoint article discusses implications of introduction of dengue vaccine on the diagnosis of dengue infections in vaccinated subjects and the strategies that are needed to tackle the issue. Copyright © 2016 Elsevier Ltd. All rights reserved.

  19. The dengue vaccine pipeline: Implications for the future of dengue control

    OpenAIRE

    Schwartz, Lauren M.; Halloran, M. Elizabeth; Durbin, Anna P.; Longini Jr., Ira M.

    2015-01-01

    Dengue has become the most rapidly expanding mosquito-borne infectious disease on the planet, surpassing malaria and infecting at least 390 million people per year. There is no effective treatment for dengue illness other than supportive care, especially for severe cases. Symptoms can be mild or life-threatening as in dengue hemorrhagic fever and dengue shock syndrome. Vector control has been only partially successful in decreasing dengue transmission. The potential use of safe and effective ...

  20. Franchising: uma estrategia para a expansao da portela cafes

    OpenAIRE

    Pereira, Fátima Patrícia

    2013-01-01

    Mestrado em Gestão A empresa em análise equaciona abrir horizontes e desenvolver novas parcerias. Por esse motivo, esta dissertação pretende reproduzir um caderno de franchising com vista à sua aplicação por parte do objeto de estudo. Face à atual conjuntura e a outros elementos cruciais, como a concorrência, só uma minoria das empresas portuguesas consegue uma rede de grande dimensão. Neste contexto, os dados nacionais apontam para a relevância do sistema de franchising enq...

  1. Kaatsu training : novas perspectivas para o treinamento resistido

    OpenAIRE

    Deus, Lysleine Alves de

    2012-01-01

    Para que um treinamento resistido possa contribuir de forma eficaz para o aumento de força e hipertrofia, muitos são os fatores que interferem na sua elaboração. Estudos ao longo dos anos vinham relatando que o treinamento resistido executado com cargas altas era o método mais eficaz para o aumento de força e hipertrofia. Em contradição a essas teorias pesquisadores japoneses desenvolveram uma nova técnica em que o treinamento resistido (TR) é executado com baixa intensidade e pouco peso asso...

  2. Novas Tecnologias Educacionais: Uma Cultura Emergente na Formação Docente

    Directory of Open Access Journals (Sweden)

    Maria Augusta Bernardo Marques de Mendon

    2015-12-01

    Full Text Available O objetivo principal desta pesquisa foi analisar a incorporação da cultura emergente na formação docente, ou seja, compreender como as novas tecnologias, recentemente difundidas nos meios educacionais, vêm sendo tratadas pelos processos de formação continuada e incluídas nas práticas pedagógicas. Na delimitação do estudo, procuramos investigar as dificuldades dos professores com a utilização dos novos recursos tecnológicos, considerando-se os fatores internos e externos que possam estar inviabilizando o sucesso da inclusão digital no ambiente escolar da rede pública estadual. Assim, por meio da pesquisa qualitativa e avaliativa propiciada por um projeto de ação, buscamos entender as interferências que ocorrem na prática docente por meio de observações direcionadas ao desempenho dos professores na utilização dos recursos tecnológicos da sala de informática como instrumentos de desenvolvimento do ensino dos conteúdos escolares. Os resultados obtidos no projeto de ação originaram-se de declarações dos sujeitos e de observações estabelecidas nos módulos de capacitação e de aplicação dos planos de aulas. Esses resultados convergem para os fatores desestimulantes como: excesso de movimentações dos docentes entre as escolas; ausência de pessoas credenciadas na própria escola capazes de coordenar as novas tecnologias educacionais e proporcionar segurança aos docentes; falta de capacitações no próprio ambiente escolar; carência de multiplicadores locais; ausência da previsão de tempo da preparação de aulas com os novos recursos tecnológicos na própria carga horária do professor e a inexistência de regulamentação na gestão administrativa que valorize o certificado da formação continuada. Enfim, as informações analisadas nessa pesquisa pelos aspectos positivos e negativos oferecem espaço para novas investigações dessa natureza.

  3. Dengue-associated neuromuscular complications

    OpenAIRE

    Ravindra Kumar Garg; Hardeep Singh Malhotra; Amita Jain; Kiran Preet Malhotra

    2015-01-01

    Dengue is associated with many neurological dysfunctions. Up to 4% of dengue patients may develop neuromuscular complications. Muscle involvement can manifest with myalgias, myositis, rhabdomyolysis and hypokalemic paralysis. Diffuse myalgia is the most characteristic neurological symptom of dengue fever. Dengue-associated myositis can be of varying severity ranging from self-limiting muscle involvement to severe dengue myositis. Dengue-associated hypokalemic paralysis often has a rapidly evo...

  4. Typical examples of classical novae

    Science.gov (United States)

    Hack, Margherita; Selvelli, Pierluigi; Bianchini, Antonio; Duerbeck, Hilmar W.

    1993-09-01

    Because of the very complicated individualistic behavior of each nova, we think it necessary to review the observations of a few well-observed individuals. We have selected a few objects of different speed classes, which have been extensively observed. They are: V1500 Cygni 1975, a very fast nova; V603 Aql 1918, fast nova; CP Pup 1942, fast nova; GK Per 1901, fast nova; V 1668 Cyg 1979, moderately fast nova; FH Ser 1970, slow nova; DQ Her 1934, slow nova; T Aur 1891, slow nova; RR Pic 1925, slow nova; and HR Del 1967, very slow nova.

  5. O papel das instituições sociais ante o desafio de inovar os processos de gestão territorial: uma análise comparativa entre o Grande ABC Paulista e os municípios do Eixo Dutra.

    OpenAIRE

    Wiliam Retamiro

    2015-01-01

    O presente trabalho objetiva debater o papel das instituições sociais universais como ferramenta essencial para transformar uma sociedade por meio de uma nova visão econômica. Desenvolvido por uma metodologia bibliográfica e documental, este artigo tece uma análise de como as instituições sociais, sendo o Estado, a economia e universidade podem interferir na realidade socioeconômica de um território, outrora imutável quanto a sua realidade para uma nova perspectiva de mutação promissora. Dial...

  6. Nova outburst modeling and its application to the recurrent nova phenomenon

    International Nuclear Information System (INIS)

    Sparks, W.M.; Starrfield, S.; Truran, J.

    1985-12-01

    The thermonuclear runaway (TNR) theory for the cause of the common novae is reviewed. Numerical simulations of this theory were performed using an implicit hydrodynamic Lagrangian computer code. Relevant physical phenomena are explained with the simpler envelope-in-place calculations. Next the models that include accretion are discussed. The calculations agree very well with observations of common novae. The observational differences between common novae and recurrent novae are examined. We propose input parameters to the TNR model which can give the outburst characteristics of RS Ophiuchi and discuss the implications. This review is concluded with a brief discussion of two current topics in novae research: shear mixing on the white dwarf and Neon novae. 36 refs., 4 figs

  7. Novas tecnologias no estudo de ondas sonoras

    Directory of Open Access Journals (Sweden)

    Marisa Almeida Cavalcante

    2013-10-01

    Full Text Available http://dx.doi.org/10.5007/2175-7941.2013v30n3p579 O presente trabalho propõe a construção de um Tubo de Kundt adaptado às novas tecnologias disponíveis para o ensino de física. Tem como principal objetivo utilizar a placa Arduino em experimentos didáticos envolvendo o estudo de ondas sonoras. O Arduino é uma placa de controle I/O baseada no micro-controlador Atmega (Atmel e foi projetado inicialmente para fins didáticos. O fato da linguagem de programação utilizada e hardware serem do tipo open source (código aberto possibilitou sua ampla difusão em diversas áreas. Uma das intenções deste projeto é difundir o uso deste recurso para fins educacionais e particularmente no estudo de ondas sonoras estacionarias em tubos, contribuindo com a melhora na abordagem deste conteúdo no ensino e aprendizagem de Física.

  8. Dengue viral infections

    Directory of Open Access Journals (Sweden)

    Gurugama Padmalal

    2010-01-01

    Full Text Available Dengue viral infections are one of the most important mosquito-borne diseases in the world. Presently dengue is endemic in 112 countries in the world. It has been estimated that almost 100 million cases of dengue fever and half a million cases of dengue hemorrhagic fever (DHF occur worldwide. An increasing proportion of DHF is in children less than 15 years of age, especially in South East and South Asia. The unique structure of the dengue virus and the pathophysiologic responses of the host, different serotypes, and favorable conditions for vector breeding have led to the virulence and spread of the infections. The manifestations of dengue infections are protean from being asymptomatic to undifferentiated fever, severe dengue infections, and unusual complications. Early recognition and prompt initiation of appropriate supportive treatment are often delayed resulting in unnecessarily high morbidity and mortality. Attempts are underway for the development of a vaccine for preventing the burden of this neglected disease. This review outlines the epidemiology, clinical features, pathophysiologic mechanisms, management, and control of dengue infections.

  9. Dengue viral infections

    OpenAIRE

    Gurugama Padmalal; Garg Pankaj; Perera Jennifer; Wijewickrama Ananda; Seneviratne Suranjith

    2010-01-01

    Dengue viral infections are one of the most important mosquito-borne diseases in the world. Presently dengue is endemic in 112 countries in the world. It has been estimated that almost 100 million cases of dengue fever and half a million cases of dengue hemorrhagic fever (DHF) occur worldwide. An increasing proportion of DHF is in children less than 15 years of age, especially in South East and South Asia. The unique structure of the dengue virus and the pathophysiologic responses of the host...

  10. Hemoterapia e febre Dengue Blood banking e Dengue fever

    Directory of Open Access Journals (Sweden)

    Estácio F. Ramos

    2008-02-01

    Full Text Available Dengue is an endemic/epidemic arboviral disease with a variable symptomatic benign course, but potentially fatal. Once in an inhabited area, the disease will exist forever, with the best achievement being to keep vectors suppressed and the disease under control. Tiger mosquitoes (aedes aegypti, aedes albopictus are active breeders and urban hunters, becoming resistant to pesticides. Global warming and population growth are propelling the disease worldwide at tropical and subtropical regions, victimizing new populations. Dengue virus is very infective, and has been transmitted by needlestick, intrapartum, through blood transfusion and mucosal contact with blood. One patient got dengue while undergoing bone marrow transplantation. We address the growing dengue epidemics in Brazil, with more than half a million official cases in 2007, to estimate the risks of transfusion transmitted dengue. Calculations however were surpassed by reality: the major Blood Center in Brazil (FHSP-USP has found dengue virus in one out of each thousand blood units. In 2007, industry sold 2,6 million disposable blood bags in Brazil. Plotting data from FHSP-USP to the whole country, 2600 blood units would have been infective. Through blood components, around 5000 patients must have received dengue virus intravenously. Beatty et al. estimated to be 1:1300 the risk for dengue transmission through blood transfusion in Puerto Rico, close to what has been demonstrated in Sao Paulo. Throughout Brazil, the average risk may be lower, but the epidemics grows towards a worst scenario. Whatever the risk is, it imposes that all blood units in Brazil (and wherever dengue is endemic must be EIA tested for dengue NS1 antigen. This marker appears early after infection, and the EIA testing platform is available at all blood banks. Also, donors must report febrile states up to two weeks after donation. Morbidity from dengue virus injected in hospitalized patients is unknown, but it may lead

  11. A culinária tradicional diamantinense como atrativo turístico: uma nova possibilidade

    Directory of Open Access Journals (Sweden)

    Mariana Costa Zaidan

    2016-12-01

    Full Text Available Buscando ferramentas de utilização da atividade turística como oportunidade de inclusão, de aumento da renda e do bem-estar social foi elaborada a proposta do I Festival de Gastronomia de Diamantina e Distritos. Uma pesquisa desenvolvida pela Universidade Federal dos Vales do Jequitinhonha e Mucuri identificou e catalogou mais de trezentas receitas, incluindo pratos que datam da primeira metade do século XX. Os resultados dessa pesquisa foram considerados como base para a organização do Festival, que foi desenvolvido em comunidades rurais em situação de vulnerabilidade social. Baseado em reflexões sobre turismo gastronômico, participação comunitária e sobre as possibilidades de alcance do turismo para o desenvolvimento local, este trabalho visa investigar os resultados da realização do I Festival Gastronômico de Diamantina e Distritos. Para cumprir tal objetivo, foi realizada pesquisa teórica sobre os aspectos da gastronomia local, turismo rural e turismo gastronômico e pesquisa empírica durante a realização dos eventos, por meio de entrevistas semiestruturadas com moradores dos distritos e com os visitantes A culinária tradicional diamantinense como atrativo turístico: uma nova possibilidade 2 Marketing & Tourism Review • Belo Horizonte - MG - Brasil • v. 1, n. 2, 2016 NEECIM TUR • Núcleo de Estudos e Estratégias em Comunicação Integrada de Marketing e Turismo • UFMG do evento. Após a finalização do projeto foi também aplicado um método de avaliação participativa em grupo, onde os participantes do evento estabeleceram os critérios a serem avaliados. A pesquisa realizada durante o projeto teve a intenção verificar se o mesmo contribuiu para valorização da tradição culinária e da produção associada ao turismo, promovendo o desenvolvimento socioeconômico da região de Diamantina. As pesquisas revelaram que o projeto teve impactos socioeconômicos significativos nos distritos, diversos

  12. NOVAS PERSPECTIVAS DA RESPONSABILIDADE PROCESSUAL NO BRASIL: O PRINCÍPIO DA BOA-FÉ OBJETIVA E O DEVIDO PROCESSO LEGAL

    Directory of Open Access Journals (Sweden)

    Thiago Rodrigues de Pontes Bomfim

    2016-09-01

    Full Text Available O presente estudo busca, inicialmente, demonstrar o caráter normativo dos princípios constitucionais, bem como seu papel no que acaba por se transformar em uma nova ordem processual, para, por fim, uma vez reconhecido o caráter de princípio jurídico à boa-fé objetiva, situar seu fundamento constitucional em um novo conceito de devido processo legal.

  13. Nova espécie de Dasineura Rondani, 1840 (Diptera, Cecidomyiidae em capítulos de Hypochaeris chillensis (Kunth Britton (Asteraceae para o Brasil

    Directory of Open Access Journals (Sweden)

    Alessandre Pereira-Colavite

    2013-01-01

    Full Text Available Uma nova espécie de Dasineura Rondani, 1840 (Diptera, Cecidomyiidae para o Brasil, Dasineura occulta sp. nov., é descrita associada a Hypochaeris chillensis (Kunth Britton (Asteraceae, uma espécie invasora e característica de ambientes antropizadas. Esta nova espécie foi encontrada ocupando capítulos e não há formação de galhas ou alterações no tecido das inflorescências que possam ser reconhecidas externamente. São apresentados desenhos de caracteres morfológicos de adultos (macho e fêmea, larva e pupa. Pranchas da ocupação do hospedeiro também são incluídas.

  14. Dengue human infection models to advance dengue vaccine development.

    Science.gov (United States)

    Larsen, Christian P; Whitehead, Stephen S; Durbin, Anna P

    2015-12-10

    Dengue viruses (DENV) currently infect approximately 400 million people each year causing millions to seek care and overwhelming the health care infrastructure in endemic areas. Vaccines to prevent dengue and therapeutics to treat dengue are not currently available. The efficacy of the most advanced candidate vaccine against symptomatic dengue in general and DENV-2 in particular was much lower than expected, despite the ability of the vaccine to induce neutralizing antibody against all four DENV serotypes. Because seroconversion to the DENV serotypes following vaccination was thought to be indicative of induced protection, these results have made it more difficult to assess which candidate vaccines should or should not be evaluated in large studies in endemic areas. A dengue human infection model (DHIM) could be extremely valuable to down-select candidate vaccines or therapeutics prior to engaging in efficacy trials in endemic areas. Two DHIM have been developed to assess the efficacy of live attenuated tetravalent (LATV) dengue vaccines. The first model, developed by the Laboratory of Infectious Diseases at the U. S. National Institutes of Health, utilizes a modified DENV-2 strain DEN2Δ30. This virus was derived from the DENV-2 Tonga/74 that caused only very mild clinical infection during the outbreak from which it was recovered. DEN2Δ30 induced viremia in 100%, rash in 80%, and neutropenia in 27% of the 30 subjects to whom it was given. The Walter Reed Army Institute of Research (WRAIR) is developing a DHIM the goal of which is to identify DENV that cause symptomatic dengue fever. WRAIR has evaluated seven viruses and has identified two that meet dengue fever criteria. Both of these models may be very useful in the evaluation and down-selection of candidate dengue vaccines and therapeutics. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

  15. O que a saúde tem a ver com rádio comunitária?: uma análise de uma experiência em Nova Friburgo - RJ What does health have to do with community radio?: an analysis of an experience in Nova Friburgo - State of Rio de Janeiro

    Directory of Open Access Journals (Sweden)

    Alfredo de Oliveira Neto

    2013-02-01

    Full Text Available O campo da Comunicação e Saúde no Brasil vem se desenvolvendo e se fortalecendo a cada Conferência Nacional de Saúde (CNS. No relatório final da XII CNS, em 2003, torna-se claro o reconhecimento das rádios comunitárias como instrumento de divulgação e produção de temas relacionados ao SUS. O objetivo foi analisar as relações que se estabelecem entre profissionais de saúde, ouvintes/usuários e comunicadores envolvidos com uma rádio comunitária, de modo a entender como são constituídos os nexos entre um programa de rádio sobre saúde e os imaginários desses sujeitos. Para tal, uma abordagem metodológica qualitativa, fazendo-se uso da etnografia e do estudo de recepção. O campo se constituiu de um programa sobre saúde, o Bloco Mulher Saúde, transmitido pela rádio comunitária Rádio Comunidade FM 104,9 no município de Nova Friburgo, RJ. As discussões foram divididas em categorias analíticas. A comunicação comunitária pode contribuir como mediador político-cultural ampliando as possibilidades de expressão das demandas sobre saúde; existe a manutenção e reprodução do linguajar técnico hegemônico em saúde pelos médicos ao participarem de uma rádio comunitária; a comunicação comunitária pode auxiliar na construção de estratégias para ampliar o controle social no SUS.The field of Communication and Health in Brazil has been developing and getting stronger after each National Health Conference (NHC. In the final report of the XII NHC, in 2003, there was clear recognition that community radio is an instrument for the dissemination and treatment of issues related to the Brazilian Unified Health System (SUS. This study seeks to analyze the relationships that are established between health professionals, listeners/users and popular communicators as a means of understanding the nexus between a radio program on health and the imaginations of the listeners. A qualitative methodological approach was used of

  16. Virological study of a dengue type 1 epidemic at Rio de Janeiro

    Directory of Open Access Journals (Sweden)

    Rita Maria R. Nogueira

    1988-06-01

    Full Text Available A dengue outbreak started in March, 1986 in Rio de Janeiro and spread very rapidly to other parts of the country. The great majority of cases presented classical dengue fever but there was one fatal case, confirmed by virus isolation. Dengue type 1 strains were isolated from patients and vectors (Aedes aegypti in the area by cultivation in A. albopictus C6/36 cell line. The cytopathic effect (CPE was studied by electron microscopy. An IgM capture test (MAC-ELISA was applied with clear and reproducible results for diagnosis and evaluation of virus circulation; IgM antibodies appeared soon after start of clinical disease, and persisted for about 90 days in most patients. The test was type-specific in about 50% of the patients but high levels of heterologous response for type 3 were observed. An overall isolation rate of 46,8% (813 virus strains out of 1734 specimens was recorded. The IgM test increased the number of confirmed cases to 58,2% (1479 out of 2451 suspected cases. The importance of laboratory diagnosis in all regions where the vectors are present is emphasized.Uma epidemia de dengue iniciou-se em março de 1986, no Rio de Janeiro, alcançando rapidamente outras partes do país. Febre dengue clássica foi observada, porém o vírus do dengue foi isolado de um caso fatal. As amostras de dengue 1 isoladas de pacientes e de fêmeas adultas de Aedes aegypti capturadas na área apresentaram efeito citopático na linhagem de células A. albopictus clone C6/36. A lesão celular foi estudada também em microscopia eletrônica, sendo descritos os dados observados. Um teste de captura para IgM (MAC-ELISA foi utilizado durante a epidemia tanto para o diagnóstico como para avaliarr a circulação de vírus, com resultados claros e reprodutíveis; os anticorpos IgM apareceram precocemente após o início da doença clínica, permanecendo por cerca de 90 dias na maioria dos pacientes. A reação mostrou-se tipo específico em cerca de 50% dos

  17. Post-dengue parkinsonism

    OpenAIRE

    Azmin, Shahrul; Sahathevan, Ramesh; Suehazlyn, Zainudin; Law, Zhe Kang; Rabani, Remli; Nafisah, Wan Yahya; Tan, Hui Jan; Norlinah, Mohamed Ibrahim

    2013-01-01

    Background Dengue is a common illness in the tropics. Equally common are neurological complications that stem from dengue infection. However, to date, parkinsonism following dengue has not been reported in medical literature. Case presentation A previously well 18-year old man developed parkinsonism, in addition to other neurological symptoms following serologically confirmed dengue fever. Alternative etiologies were excluded by way of imaging and blood investigations. Conclusions The authors...

  18. Autoimmunity in dengue pathogenesis

    Directory of Open Access Journals (Sweden)

    Shu-Wen Wan

    2013-01-01

    Full Text Available Dengue is one of the most important vector-borne viral diseases. With climate change and the convenience of travel, dengue is spreading beyond its usual tropical and subtropical boundaries. Infection with dengue virus (DENV causes diseases ranging widely in severity, from self-limited dengue fever to life-threatening dengue hemorrhagic fever and dengue shock syndrome. Vascular leakage, thrombocytopenia, and hemorrhage are the major clinical manifestations associated with severe DENV infection, yet the mechanisms remain unclear. Besides the direct effects of the virus, immunopathogenesis is also involved in the development of dengue disease. Antibody-dependent enhancement increases the efficiency of virus infection and may suppress type I interferon-mediated antiviral responses. Aberrant activation of T cells and overproduction of soluble factors cause an increase in vascular permeability. DENV-induced autoantibodies against endothelial cells, platelets, and coagulatory molecules lead to their abnormal activation or dysfunction. Molecular mimicry between DENV proteins and host proteins may explain the cross-reactivity of DENV-induced autoantibodies. Although no licensed dengue vaccine is yet available, several vaccine candidates are under development. For the development of a safe and effective dengue vaccine, the immunopathogenic complications of dengue disease need to be considered.

  19. Novas centralidades na perspectiva da relação centro – periferia / New centralities under the relation town center – periphery perspective

    Directory of Open Access Journals (Sweden)

    Wilson Martins Lopes Junior

    2009-12-01

    Full Text Available Alterações na organização espacial das cidades expressam o surgimento de novas áreas com atividades comerciais, de serviços e também um fluxo que expressa á centralidade. Neste processo, ocorre a descontinuidade do território da cidade e a criação de novos espaços que representam a relação centro – periferia. A relação centro-periferia torna-se tema relevante no estudo de novas centralidades uma vez que a morfologia urbana é alterada diante da definição de novas centralidades e a formação de outras periferias. Deste modo a cidade através de seu tecido urbano apresenta uma dinâmica contraditória de concentração e descentralização dos espaços urbanos redefinindo a relação centro-periferia, que evidencia as novas centralidades. Portanto, a concentração e descentralização que ocorre no urbano refletem em nova dinâmica no espaço intra-urbano, apresentando novas centralidades atreladas às novas localizações de grupos – empresas de comércio e de serviços, favorecendo a fragmentação espacial. Finalmente tem-se a produção de espaços interiores na cidade com suas funções específicas como: produção, consumo, moradia, e outras que influem no valor destas áreas, de acordo com sua característica ou tipo de atividade. Assim, criam-se vários centros com funções distintas evidenciados primeiramente em metrópoles e grandes cidades e num segundo momento em cidades médias contrapondo-se a antiga cidade (pequena, com centro único.

  20. Mapeamentos conceituais entre os modelos relacional e NoSQL: Uma abordagem comparativa

    Directory of Open Access Journals (Sweden)

    Myller Claudino Freitas

    2015-12-01

    Full Text Available As atuais perspectivas computacionais, vindas sobretudo da Web, têm gerado novas demandas relacionadas ao gerenciamento de dados, principalmente em termos de volume, heterogeneidade e dinamismo. Uma tendência atual para facilitar o gerenciamento de dados na Web é a utilização dos denominados Sistemas NoSQL, que se diferenciam dos sistemas que seguem o Modelo Relacional por possibilitarem a implementação de estruturas mais flexíveis. Contudo, a maioria dos bancos de dados de aplicações existentes encontra-se em estruturas relacionais, e a migração de uma base que segue o Modelo Relacional para uma NoSQL requer grande esforço dos projetistas diante das diferenças existentes. Nesse panorama, este artigo descreve os modelos citados, em termos de conceitos e estruturas, e apresenta um estudo comparativo apontando possíveis mapeamentos conceituais entre eles. Aborda também, de forma comparativa, trabalhos de conversão de dados existentes, e indica desafios e possibilidades para novas pesquisas sobre o tema.

  1. Dengue virus receptor

    OpenAIRE

    Hidari, Kazuya I.P.J.; Suzuki, Takashi

    2011-01-01

    Dengue virus is an arthropod-borne virus transmitted by Aedes mosquitoes. Dengue virus causes fever and hemorrhagic disorders in humans and non-human primates. Direct interaction of the virus introduced by a mosquito bite with host receptor molecule(s) is crucial for virus propagation and the pathological progression of dengue diseases. Therefore, elucidation of the molecular mechanisms underlying the interaction between dengue virus and its receptor(s) in both humans and mosquitoes is essent...

  2. Contribuição para o estudo dos Rhinotragini (Coleoptera, Cerambycidae: VIII. Transferências e nova espécie em Clepitoides

    Directory of Open Access Journals (Sweden)

    Antonio Santos-Silva

    2013-01-01

    Full Text Available Quatro espécies são transferidas para Clepitoides Clarke, 2009: Odontocera crocata Bates, 1873; O. virgata Gounelle, 1911; Eclipta picturata (Gounelle, 1911; E. pallidicornis (Zajciw, 1966. As fêmeas de O. crocata e O. pallidicornis são redescritas e uma nova espécie é descrita do Brasil e da Argentina. As cinco espécies são figuradas. Adicionalmente é fornecida nova chave para as espécies de Clepitoides.

  3. Novos sinônimos e uma nova combinação em Pusillanthus (Loranthaceae New synonyms and a new combination in Pusillanthus (Loranthaceae

    Directory of Open Access Journals (Sweden)

    Claudenir Simões Caires

    2012-09-01

    Full Text Available Uma revisão de Pusillanthus Kuijt para o Brasil é apresentada. O gênero monotípico recém-descrito ocorre na Venezuela, Guiana e Brasil. No Brasil, distribui-se somente na Caatinga, nos estados de Alagoas, Bahia e Paraíba. A nova combinação Pusillanthus pubescens (Rizzini Caires é proposta e as espécies Phthirusa caatingae Rizzini, Pusillanthus trichodes (Rizzini Kuijt e Struthanthus pubescens var. bahiensis Rizzini são tratadas como seus sinônimos taxonômicos. Uma prancha ilustrativa e um mapa de distribuição para o gênero no Brasil são apresentados, bem como estudos da arquitetura foliar, de superfícies de caule, folha e grãos de pólen usando Microscopia Eletrônica de Varredura.A revision of Pusillanthus Kuijt for Brazil is presented. The recently described monotypic genus occurs in Venezuela, Guyana, and Brazil. In Brazil, it is distributed only within the Caatinga domain, in the states of Alagoas, Bahia and Paraíba. The new combination Pusillanthus pubescens (Rizzini Caires is proposed and the species Phthirusa caatingae Rizzini, Pusillanthus trichodes (Rizzini Kuijt, and Struthanthus pubescens var. bahiensis Rizzini are treated as its taxonomic synonyms. An illustrative plate and a distribution map for the genus in Brazil are presented, as well as information about leaf architecture, and stem, leaf, and pollen grain surfaces (based on scanning electron microscopy.

  4. Dengue retinochoroiditis.

    Science.gov (United States)

    Tabbara, Khalid

    2012-01-01

    Dengue is a mosquito-borne infection caused by a flavivirus. I describe the ocular findings observed in two patients infected with dengue virus who presented with acute onset of loss of vision preceded by febrile illness, malaise, generalized fatigue headache, and maculopapular rash. Ophthalmologic evaluation in each patient revealed a normal anterior segment. Vitreous cells were noted in one patient. Ophthalmoscopy revealed multiple foci of retinochoroiditis, vasculitis, cotton-wool spots, and retinal hemorrhages. The healing of the lesion showed discrete atrophic and pigmented retinochoroiditic scars. Fluorescein angiography displayed early hypofluorescence and late hyperfluorescence suggestive of leakage. The healed scars showed late staining. The serologic testing showed elevated IgG antibodies, and one had high IgM antibodies to dengue virus. Ocular findings of dengue fever consist of multifocal areas of retinochoroiditis and may lead to loss of vision. In Saudi Arabia, dengue fever should be considered in the differential diagnosis of multifocal chorioretinal lesions and retinal vasculitis.

  5. Novas formas organizacionais: a necessidade de superação das perspectivas sobressocializadas e subsocializadas

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    Mariana Baldi

    Full Text Available Este trabalho tem como pressuposto que a análise de novas formas organizacionais deve superar tanto perspectivas sobressocializadas quanto perspectivas subsocializadas. Isso quer dizer que é necessário superar, respectivamente, os estudos que reduzem a explicação de formas organizacionais a aspectos de origem puramente cultural, como também aqueles que reduzem sua explicação a aspectos puramente econômicos ou de mercado. As formas organizacionais sociais e econômicas apresentam, simultaneamente, uma dependência e uma autonomia em relação aos quadros cultural e institucional de cada país, estando imbricadas nesses quadros. Numa perspectiva contextualizada, múltiplas identidades se tornam possíveis, as quais não são necessariamente oriundas de uma cultura dominante. De acordo com Clegg (1998, o objeto de análise não deve ser necessariamente as organizações em si, mas os processos e mecanismos que permitem a organização e a desorganização. É proposta a perspectiva do embeddedness como um referencial de análise que supera os limites das abordagens comumente utilizadas para identificar e compreender as novas formas organizacionais. O conceito de embeddedness e seus mecanismos permitem trazer à tona várias narrativas (cultural, política, estrutural e cognitiva, e através delas se compreende como as organizações são formadas e mudadas, possibilitando enfocar questões por uma ótica ainda pouco trabalhada nos estudos organizacionais.

  6. KQ Mon and the nature of the UX Ursa Majoris nova-like variables

    International Nuclear Information System (INIS)

    Sion, E.M.; Guinan, E.F.

    1983-01-01

    New ultraviolet spectra of KQ Mon, a UX UMa type nova-like variable, are presented. The data derived from these spectra shed considerable light on its lack of major outbursts, a feature shared by other UX UMa stars, as well as on the absence of stellar winds in KQ Mon in contrast to the UX UMa stars. The author compares de-reddened continuum fluxes obtained from the data with values available from theoretical accretion disk models. A rather high steady accretion rate of 10 -8 solar masses per year turns out. This property seems to be responsible for their lack of major outbursts. 0ecause of a sub-critical value of the accretion flow, a wind outflow is absent in KQ Mon. The calculations are based on time-independent steady state disk structure. (G.J.P.)

  7. Could peak proteinuria determine whether patient with dengue fever develop dengue hemorrhagic/dengue shock syndrome? - A prospective cohort study

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    Suhail Sufi M

    2011-08-01

    Full Text Available Abstract Background Worldwide there is a need to develop simple effective predictors that can distinguish whether a patient will progress from dengue fever (DF to life threatening dengue hemorrhagic (DHF or dengue shock syndrome (DSS. We explored whether proteinuria could be used as such a marker. Methods We included patients admitted to hospital with suspected dengue fever. Starting at enrollment until discharge, each patient's daily spot urine protein creatinine ratio (UPCR was measured. We classified those with confirmed dengue infection as DF or DHF (including DSS based on WHO criteria. Peak and day of onset of proteinuria was compared between both groups. Results Compared to those with DF, patients with DHF had significantly higher median peak proteinuria levels (0.56 versus 0.08 g/day; p Conclusions Peak UPCR could potentially predict DHF in patients with dengue requiring close monitoring and treatment.

  8. Uma nova metodologia para dimensionamento de sistemas híbridos de energia (solar-eólica utilizando ferramentas de simulação e otimização - DOI: 10.4025/actascitechnol.v27i1.1506

    Directory of Open Access Journals (Sweden)

    Carlos Eduardo Camargo Nogueira

    2005-03-01

    Full Text Available Este trabalho apresenta uma nova metodologia para dimensionamento de sistemas híbridos de energia (solar-eólica com armazenamento em banco de baterias, utilizando ferramentas de simulação e otimização. O modelo desenvolvido é útil para a energização de áreas rurais isoladas e resulta num sistema com custo mínimo e alta confiabilidade, baseado no conceito de perda de fornecimento de energia à carga (LPSP aplicado para horas consecutivas. Alguns cenários são calculados e comparados, utilizando-se diferentes períodos de horas consecutivas e diferentes valores de LPSP. Os resultados apresentam um dimensionamento completo do sistema e uma avaliação de custos ao longo de vários anos

  9. Dengue in children

    NARCIS (Netherlands)

    Verhagen, L.M.; Groot, R. de

    2014-01-01

    Dengue is a mosquito-borne viral disease of expanding geographical range and increasing incidence. The vast majority of dengue cases are children less than 15 years of age. Dengue causes a spectrum of illness from mild fever to severe disease with plasma leakage and shock. Infants and children with

  10. Points for Consideration for dengue vaccine introduction - recommendations by the Dengue Vaccine Initiative.

    Science.gov (United States)

    Lim, Jacqueline Kyungah; Lee, Yong-Seok; Wilder-Smith, Annelies; Thiry, Georges; Mahoney, Richard; Yoon, In-Kyu

    2016-01-01

    Dengue is a public health problem in the tropics and subtropics. There are several vaccine candidates in clinical development. However, there may be gaps in the new vaccine introduction after vaccine licensure before it becomes available in developing countries. In anticipation of the first dengue vaccine candidate to be licensed, Dengue Vaccine Initiative (DVI) and, its predecessor, Pediatric Dengue Vaccine Initiative (PDVI) have been working on points for consideration to accelerate evidence-based dengue vaccine introduction, once a vaccine becomes available. In this paper, we review the history of PDVI and its successor, the DVI, and elaborate on the points of consideration for dengue vaccine introduction.

  11. The classical nova outburst

    International Nuclear Information System (INIS)

    Starrfield, S.G.

    1988-01-01

    The classical nova outburst occurs on the white dwarf component in a close binary system. Nova systems are members of the general class of cataclysmic variables and other members of the class are the Dwarf Novae, AM Her variables, Intermediate Polars, Recurrent Novae, and some of the Symbiotic variables. Although multiwavelength observations have already provided important information about all of these systems, in this review I will concentrate on the outbursts of the classical and recurrent novae and refer to other members of the class only when necessary. 140 refs., 1 tab

  12. DengueTools: innovative tools and strategies for the surveillance and control of dengue

    Directory of Open Access Journals (Sweden)

    Annelies Wilder-Smith

    2012-03-01

    Full Text Available Dengue fever is a mosquito-borne viral disease estimated to cause about 230 million infections worldwide every year, of which 25,000 are fatal. Global incidence has risen rapidly in recent decades with some 3.6 billion people, over half of the world's population, now at risk, mainly in urban centres of the tropics and subtropics. Demographic and societal changes, in particular urbanization, globalization, and increased international travel, are major contributors to the rise in incidence and geographic expansion of dengue infections. Major research gaps continue to hamper the control of dengue. The European Commission launched a call under the 7th Framework Programme with the title of ‘Comprehensive control of Dengue fever under changing climatic conditions’. Fourteen partners from several countries in Europe, Asia, and South America formed a consortium named ‘DengueTools’ to respond to the call to achieve better diagnosis, surveillance, prevention, and predictive models and improve our understanding of the spread of dengue to previously uninfected regions (including Europe in the context of globalization and climate change.The consortium comprises 12 work packages to address a set of research questions in three areas: Research area 1: Develop a comprehensive early warning and surveillance system that has predictive capability for epidemic dengue and benefits from novel tools for laboratory diagnosis and vector monitoring. Research area 2: Develop novel strategies to prevent dengue in children. Research area 3: Understand and predict the risk of global spread of dengue, in particular the risk of introduction and establishment in Europe, within the context of parameters of vectorial capacity, global mobility, and climate change.In this paper, we report on the rationale and specific study objectives of ‘DengueTools’. DengueTools is funded under the Health theme of the Seventh Framework Programme of the European Community, Grant

  13. DengueTools: innovative tools and strategies for the surveillance and control of dengue.

    Science.gov (United States)

    Wilder-Smith, Annelies; Renhorn, Karl-Erik; Tissera, Hasitha; Abu Bakar, Sazaly; Alphey, Luke; Kittayapong, Pattamaporn; Lindsay, Steve; Logan, James; Hatz, Christoph; Reiter, Paul; Rocklöv, Joacim; Byass, Peter; Louis, Valérie R; Tozan, Yesim; Massad, Eduardo; Tenorio, Antonio; Lagneau, Christophe; L'Ambert, Grégory; Brooks, David; Wegerdt, Johannah; Gubler, Duane

    2012-01-01

    Dengue fever is a mosquito-borne viral disease estimated to cause about 230 million infections worldwide every year, of which 25,000 are fatal. Global incidence has risen rapidly in recent decades with some 3.6 billion people, over half of the world's population, now at risk, mainly in urban centres of the tropics and subtropics. Demographic and societal changes, in particular urbanization, globalization, and increased international travel, are major contributors to the rise in incidence and geographic expansion of dengue infections. Major research gaps continue to hamper the control of dengue. The European Commission launched a call under the 7th Framework Programme with the title of 'Comprehensive control of Dengue fever under changing climatic conditions'. Fourteen partners from several countries in Europe, Asia, and South America formed a consortium named 'DengueTools' to respond to the call to achieve better diagnosis, surveillance, prevention, and predictive models and improve our understanding of the spread of dengue to previously uninfected regions (including Europe) in the context of globalization and climate change.The consortium comprises 12 work packages to address a set of research questions in three areas:Research area 1: Develop a comprehensive early warning and surveillance system that has predictive capability for epidemic dengue and benefits from novel tools for laboratory diagnosis and vector monitoring.Research area 2: Develop novel strategies to prevent dengue in children.Research area 3: Understand and predict the risk of global spread of dengue, in particular the risk of introduction and establishment in Europe, within the context of parameters of vectorial capacity, global mobility, and climate change.In this paper, we report on the rationale and specific study objectives of 'DengueTools'. DengueTools is funded under the Health theme of the Seventh Framework Programme of the European Community, Grant Agreement Number: 282589 Dengue Tools.

  14. Aspectos críticos do controle do dengue no Brasil

    Directory of Open Access Journals (Sweden)

    Tauil Pedro Luiz

    2002-01-01

    Full Text Available O dengue é hoje a principal doença re-emergente no mundo. Na ausência de uma vacina preventiva eficaz, de tratamento etiológico e quimioprofilaxia efetivos, o único elo vulnerável para reduzir a sua transmissão é o mosquito Aedes aegypti, seu principal vetor. As dificuldades de combater este mosquito, em grandes e médias cidades, são muitas. Há facilidades para sua proliferação e limitações para reduzir seus índices de infestação, geradas pela complexidade da vida urbana atual. Os objetivos do controle do dengue devem ser estabelecidos com base nos conhecimentos científicos e técnicos disponíveis. Assim, não sendo possível evitar casos de dengue em áreas infestadas pelo A. aegypti, é possível prevenir epidemias de grandes dimensões por meio do aprimoramento da vigilância epidemiológica, e é possível e factível reduzir a letalidade da doença, dos níveis atuais de 5 a 6% para cerca de 1% das formas graves. A elaboração e execução de planos estratégicos de organização da assistência aos casos suspeitos de dengue têm mostrado, tanto em outros países, como em algumas cidades brasileiras, ser um instrumento muito útil na redução da letalidade.

  15. Aspectos críticos do controle do dengue no Brasil

    Directory of Open Access Journals (Sweden)

    Pedro Luiz Tauil

    2002-06-01

    Full Text Available O dengue é hoje a principal doença re-emergente no mundo. Na ausência de uma vacina preventiva eficaz, de tratamento etiológico e quimioprofilaxia efetivos, o único elo vulnerável para reduzir a sua transmissão é o mosquito Aedes aegypti, seu principal vetor. As dificuldades de combater este mosquito, em grandes e médias cidades, são muitas. Há facilidades para sua proliferação e limitações para reduzir seus índices de infestação, geradas pela complexidade da vida urbana atual. Os objetivos do controle do dengue devem ser estabelecidos com base nos conhecimentos científicos e técnicos disponíveis. Assim, não sendo possível evitar casos de dengue em áreas infestadas pelo A. aegypti, é possível prevenir epidemias de grandes dimensões por meio do aprimoramento da vigilância epidemiológica, e é possível e factível reduzir a letalidade da doença, dos níveis atuais de 5 a 6% para cerca de 1% das formas graves. A elaboração e execução de planos estratégicos de organização da assistência aos casos suspeitos de dengue têm mostrado, tanto em outros países, como em algumas cidades brasileiras, ser um instrumento muito útil na redução da letalidade.

  16. Dengue fever and dengue haemorrhagic fever in adolescents and adults.

    Science.gov (United States)

    Tantawichien, Terapong

    2012-05-01

    Dengue fever (DF) is endemic in tropical and subtropical zones and the prevalence is increasing across South-east Asia, Africa, the Western Pacific and the Americas. In recent years, the spread of unplanned urbanisation, with associated substandard housing, overcrowding and deterioration in water, sewage and waste management systems, has created ideal conditions for increased transmission of the dengue virus in tropical urban centres. While dengue infection has traditionally been considered a paediatric disease, the age distribution of dengue has been rising and more cases have been observed in adolescents and adults. Furthermore, the development of tourism in the tropics has led to an increase in the number of tourists who become infected, most of whom are adults. Symptoms and risk factors for dengue haemorrhagic fever (DHF) and severe dengue differ between children and adults, with co-morbidities and incidence in more elderly patients associated with greater risk of mortality. Treatment options for DF and DHF in adults, as for children, centre round fluid replacement (either orally or intravenously, depending on severity) and antipyretics. Further data are needed on the optimal treatment of adult patients.

  17. Neon novae, recurrent novae, and type I supernovae

    International Nuclear Information System (INIS)

    Starrfield, S.; Sparks, W.M.; Truran, J.W.; Shaviv, G.; Illinois Univ., Urbana, IL; Technion-Israel Inst. of Tech., Haifa

    1989-01-01

    Over the past few years, we have been investigating the effects of accretion onto massive white dwarfs and its implications for their growth in mass toward the Chandrasekhar limit, in attempts to identify a possible relationship between SN I and novae. In our studies we have considered accretion at various mass accretion rates onto a variety of different white dwarf masses. We have found that there is a critical white dwarf mass above which a significant fraction of the accreted mass can remain on the white dwarf after the outburst. Below this value of the white dwarf mass, all of the accreted mass, plus core material dredged up into the envelope, is ejected as a result of the explosion. Our latest results include accretion and boundary layer heating produced by the infalling material. From these studies, we have identified some members of the class of recurrent novae, those involving a thermonuclear runaway, as the novae that are occurring on very massive white dwarfs and evolving toward an SN I explosion. One of the outgrowths of our uv studies of novae in outburst has been the identification of a class of novae which eject material that is very rich in the elements from oxygen to aluminum. We have shown that these outbursts occur on ONeMg white dwarfs, which are necessarily very massive white dwarfs. 11 refs

  18. Symbiotic Novae

    OpenAIRE

    Mikolajewska, Joanna

    2010-01-01

    The symbiotic novae are thermonuclear novae in symbiotic binary systems -- interacting binaries with evolved red giant donors, and the longest orbital periods. This paper aims at presenting physical characteristics of these objects and discussing their place among the whole family of symbiotic stars.

  19. Epidemiologi dan Diagnosis Dengue di Indonesia

    OpenAIRE

    Zilhadia, Zilhadia

    2007-01-01

    Dengue fever/DF and dengue hemorrhagic fever/DHF is a global public health problem that occured in tropical and subtropical region. Epidemic dengue occurs every years, and it continues to be a major health problem in Indonesia. Due to its asymptomatic nature, a reliable, rapid and accurate dengue diagnosis is needed. Dengue diagnosis method based on molecular dengue virus properties and it will be developed by researcher. Dengue rapid test isnewly method. This article explaine about dengue ep...

  20. Dengue en Colombia

    Directory of Open Access Journals (Sweden)

    Jorge Boshell

    1986-12-01

    Full Text Available El Gobierno Colombiano estableció una campaña que erradicó el Aedes aegypti de su territorio en atención a las recomendaciones que hizo la Oficina Sanitaria Panamericana en 1947. Esta campaña consiguió desaparecer el dengue endémico durante aproximadamente 20 años, apareciendo de nuevo en forma explosiva con la epidemia de dengue 2 en la Costa Atlántica (1971-1972, seguida de dos epidemias bien documentadas de dengue 3 (1975-1977 y dengue 1 en 1978. Se hace un resumen de las actividades que desarrolla el Laboratorio de Virología del Instituto Nacional de Salud para apoyar el diagnóstico de esta enfermedad en el país incluyendo el primer aislamiento de dengue 4 en 1982, la actividad de los virus dengue 1, 2 y 4 detectada hasta la fecha, los hallazgos clínicos y virológicos en un caso fatal de enfermedad hemorrágica asociada a infección por virus del dengue y un breve recuento de la epidemia de Tumaco en la Costa Pacífica en la cual se comprobó actividad simultánea de dengue 1 y 2. Finalmente se informa sobre el estado de infestación que tiene el país actualmente con el Aedes aegypti y sobre la actividad del virus de fiebre amarilla en focos selváticos vecinos a ciudades altamente infestadas, detectada en el mes de enero de 1987 en Colombia.

  1. DENGUE VACCINE, CHALLENGES, DEVELOPMENT AND STRATEGIES

    Directory of Open Access Journals (Sweden)

    Dewi Marbawati

    2014-08-01

    Full Text Available ABSTRAKPenyakit demam Dengue endemik di lebih dari 100 negara di dunia. Obat anti virus Dengue efektif belum ditemukan danpengendalian vektor dinilai kurang efektif, sehingga diperlukan upaya pencegahan dengan vaksinasi. Vaksin Dengue yangideal adalah murah, mencakup 4 serotipe, efektif dalam memberikan kekebalan, cukup diberikan sekali seumur hidup, aman,memberi kekebalan jangka panjang, stabil dalam penyimpanan dan stabil secara genetis (tidak bermutasi. Beberapakandidat vaksin yang telah dan sedang dikembangkan oleh para peneliti di seluruh dunia adalah tetravalent live attenuatedvaccine, vaksin Chimera (ChimeriVax, vaksin subunit dan vaksin DNA. Vaksin Dengue dipandang sebagai pendekatan yangefektif dan berkesinambungan dalam mengendalikan penyakit Dengue. Tahun 2003 telah terbentuk Pediatric DengueVaccine Initiative (PDVI, yaitu sebuah konsorsium internasional yang bergerak dalam advokasi untuk meyakinkanmasyarakat internasional akan penting dan mendesaknya vaksin Dengue. Konsorsium vaksin Dengue Indonesia saat iniberupaya mengembangkan vaksin Dengue dengan menggunakan strain virus lokal.Kata kunci: Dengue, virus, vaksinABSTRACTDengue fever is endemic in more than 100 countries in the world. The effective dengue antiviral drug has not been found yet,and vector control is considered less effective. Prevention program by vaccination is needed. An ideal dengue vaccine shouldbe inexpensive, covering four serotypes (tetravalent, effective in providing immunity, given once a lifetime, safe, stable instorage and genetically. Several vaccine candidates have been and are being developed included attenuated tetravalentvaccine, ChimeriVax, sub- unit vaccines and DNA vaccines. Dengue vaccine is seen as an effective and sustainable approachto controll Dengue infection. In 2003, Pediatric Dengue Vaccine Initiative (PDVI has been formed as an internationalconsortium involved in advocacy to convince the international community about the essence and urgency

  2. Estudos da linguagem e mente corporificada: uma nova proposta gramatical Studies of language and embodied mind: a new grammar approach

    Directory of Open Access Journals (Sweden)

    Ricardo Yamashita Santos

    2011-01-01

    Full Text Available Podemos dizer que Descartes fundamentou a filosofia moderna com uma proposta universal do entendimento mundano. Dissociando as experiências corpóreas de nossa matéria pensante - mente, conseguiríamos captar a verdadeira essência de tudo por meio de um pensamento racional e objetivo. A ideia de mente corporificada, traduzida aqui pelos moldes de Lakoff e Johnson (1980, quebra com a dicotomia do filósofo e com diversas outras tradições enraizadas em nossa cultura ocidental. Nosso objetivo neste artigo é o de amparar a nova proposta teórica de mente corporificada e pensar um novo modelo gramatical que evidencie a corporalidade da mente.We can say that Descartes founded the modern philosophy with an universal proposal of the mundane understanding. Dissociating the bodily experience from our thinking matter - mind, we could capture the true essence of everything through rational and objective thought. The idea of the embodied mind, translated here by Lakoff and Johnson's theories (1980, breaks Descartes' dichotomy and various other traditions rooted in our Western culture. Our goals in this paper is to bolster the new theoretical proposition of embodied mind and think about a new grammatical model that highlights the embodiment of mind.

  3. DenguePredict: An Integrated Drug Repositioning Approach towards Drug Discovery for Dengue

    OpenAIRE

    Wang, QuanQiu; Xu, Rong

    2015-01-01

    Dengue is a viral disease of expanding global incidence without cures. Here we present a drug repositioning system (DenguePredict) leveraging upon a unique drug treatment database and vast amounts of disease- and drug-related data. We first constructed a large-scale genetic disease network with enriched dengue genetics data curated from biomedical literature. We applied a network-based ranking algorithm to find dengue-related diseases from the disease network. We then developed a novel algori...

  4. Dengue fever and dengue haemorrhagic fever in adolescents and adults

    OpenAIRE

    Tantawichien, Terapong

    2012-01-01

    Dengue fever (DF) is endemic in tropical and subtropical zones and the prevalence is increasing across South-east Asia, Africa, the Western Pacific and the Americas. In recent years, the spread of unplanned urbanisation, with associated substandard housing, overcrowding and deterioration in water, sewage and waste management systems, has created ideal conditions for increased transmission of the dengue virus in tropical urban centres. While dengue infection has traditionally been considered a...

  5. O behaviorismo radical e a interdisciplinaridade: possibilidade de uma nova síntese? Radical behaviorism and interdisciplinary research: would a new synthesis be possible in psychology?

    Directory of Open Access Journals (Sweden)

    Evenice Santos Chaves

    2005-12-01

    Full Text Available A ciência psicológica é historicamente atravessada por conflitos inter teóricos, decorrentes de enfoques diferenciados com relação a conhecimentos produzidos pelos fundamentos epistemológicos, teóricos e metodológicos, pelas hegemonias e pelo próprio recorte sobre o objeto em estudo, realizado por pesquisadores. Contemporaneamente, a epistemologia da complexidade chama atenção para a incompletude de cada tipo de conhecimento científico produzido, o que tem gerado ressonâncias nos fazeres de pesquisadores e propiciado novos diálogos entre perspectivas diversificadas em cada enfoque, ou entre enfoques. O presente artigo propõe diálogos entre aspectos do behaviorismo radical e do construtivismo crítico formal, ressaltando relações de complementaridade, a partir da unidade de contrários, que podem implicar numa nova síntese: uma teoria geral do significado. Nessa direção enfocar-se-á a proposição de nova síntese, a qual configura uma compreensão teórica sobre o desenvolvimento do significado e reinterpreta o papel do reforçamento na construção e ampliação dos significados.Psychology as science is historically engaged in theoretical disputes resulting from divergent viewpoints concerning the nature of knowledge generated by different epistemological, theoretical and methodological approaches, and by the particular divisions in the subject matter made by the researchers themselves. At the present time, epistemology of the complexity calls attention to the incompleteness, characteristic of scientific knowledge, that in turn affects the conduct of researchers, creating conditions for new dialogues between differing perspectives within and between disciplines. This article proposes a renewal of the dialogue between radical behaviorism and formal critical constructivism that, by emphasizing complementary relationships and opposing polarized thinking which has permeated these disciplines, may result in a new synthesis or

  6. Artigos Tecnológicos: Avaliação Tecnológica: Uma Proposta Metodológica

    Directory of Open Access Journals (Sweden)

    Marcella Luiza Santos Mendes

    2017-07-01

    Full Text Available Esta pesquisa tem como objetivo propor uma metodologia de apoio à avaliação de tecnologia que, por meio da cientometria e da patentometria, seja capaz de auxiliar as organizações em suas tomadas de decisão, no que se refere à introdução de novas tecnologias. A inserção de uma nova tecnologia em um cenário de incertezas pode provocar impactos dentro das organizações, por isso se faz necessária a realização de uma análise prévia. A Avaliação de Tecnologia tem como principal objetivo fornecer informações que possam minimizar os riscos e maximizar os benefícios de determinada tecnologia. A metodologia desenvolvida, composta por nove passos facilmente replicáveis, pode ser usada para ajudar especialistas que se encarregam de realizar a avaliação tecnológica nas organizações, ou, também, para assessorar os profissionais que não costumam atuar neste processo.

  7. Dengue fever

    African Journals Online (AJOL)

    symptoms and research has been limited to studies ... severity and problems with vaccination (4). History of ... Americas in 1970s reduced the spread of dengue fever. After this .... Reiter P. Yellow fever and dengue: a threat to Europe? 9.

  8. A statistical analysis of IUE spectra of dwarf novae and nova-like stars

    Science.gov (United States)

    Ladous, Constanze

    1990-01-01

    First results of a statistical analysis of the IUE International Ultraviolet Explorer archive on dwarf novae and nova like stars are presented. The archive contains approximately 2000 low resolution spectra of somewhat over 100 dwarf novae and nova like stars. Many of these were looked at individually, but so far the collective information content of this set of data has not been explored. The first results of work are reported.

  9. Psychosis in dengue fever

    OpenAIRE

    Suprakash Chaudhury; Biswajit Jagtap; Deepak Kumar Ghosh

    2017-01-01

    An 18-year-old male student developed abnormal behavior while undergoing treatment for dengue fever. He was ill-kempt, irritable and had auditory and visual hallucinations and vague persecutory delusions in clear sensorium with impaired insight. The psychotic episode had a temporal correlation with dengue fever. Psychiatric comorbidities of dengue fever including mania, anxiety, depression, and catatonia are mentioned in literature but the literature on the psychosis following dengue is spars...

  10. Uma arquitetura para agentes inteligentes com personalidade e emoção

    OpenAIRE

    Ary Fagundes Bressane Neto

    2010-01-01

    Uma das principais motivações da Inteligência Artificial no contexto dos sistemas de entretenimento digital é criar personagens adaptáveis a novas situações, pouco previsíveis, com aprendizado rápido, memória de situações passadas e uma grande diversidade de comportamentos consistente e convincente ao longo do tempo. De acordo com recentes estudos desenvolvidos nos campos da Neurociência e da Psicologia, a capacidade de resolução de problemas não está unicamente atrelada à facilidade na manip...

  11. Nova target experiments

    International Nuclear Information System (INIS)

    Drake, R.P.

    1985-11-01

    The Nova laser, at the Lawrence Livermore National Laboratory, provides unique opportunities for target experiments. It has unprecedented energy on target and significant flexibility. The paper presented by John Hunt described the capabilities and the status of Nova. This paper discusses plans for future experiments using Nova, and the present status of target experiments. We plan to perform high-quality physics experiments that exploit the unique capabilities of Nova. Because this is our goal, we are fielding an extensive array of well-characterized target diagnostics to measure the emissions from the target. The first section of this paper discusses the basic target diagnostics. We are also taking care to quantify the performance of the laser

  12. Caracterização hidroambiental da bacia hidrográfica do rio Debossan, Nova Friburgo, RJ Enviromental characterization of Debossan river watershed, Nova Friburgo, RJ

    Directory of Open Access Journals (Sweden)

    Christiany Araujo Cardoso

    2006-04-01

    Full Text Available O objetivo deste trabalho foi caracterizar o comportamento hidrológico, o volume de entrada e saída de água da bacia hidrográfica do rio Debossan, onde se localiza uma importante estação de captação de água, administrada pela Concessionária de Águas e Esgotos de Nova Friburgo LTDA. (CAENF, inserida na Reserva Ecológica de Macaé de Cima, Município de Nova Friburgo, Rio de Janeiro. Para isso, foram obtidos dados de vazão e precipitação diários do período de janeiro de 2002 a dezembro de 2004. A partir desses dados, foram calculados alguns parâmetros hidrológicos, como vazão específica e deflúvio. A precipitação média observada nos três anos foi de 2.163 mm, sendo que os meses de dezembro/2002 e janeiro/2003 apresentaram os máximos valores. A vazão média anual no período foi de 0,86 m³/s, apresentando o mês de dezembro de 2002 com maior índice e setembro de 2004 com o menor. O balanço hídrico, em termos médios anuais nos três anos de medições, apresentou uma evapotranspiração de 1.923,04 mm, equivalendo a 88% da precipitação convencional. Pode-se dizer que o ecossistema florestal exerce efeito tamponante sobre a quantidade de água da bacia hidrográfica, mantendo uma grande vazão nos meses de menor pluviosidade. Ao analisar a relação entre a entrada de água na bacia, o uso atual do solo e a quantidade de água produzida, concluiu-se que uma bacia hidrográfica bem preservada tem fundamental importância na manutenção constante da vazão ao longo do ano, além da visível participação na qualidade da água.The objective of this work was to characterize the hydrological behavior and the volume of water entering and leaving the Debossan river watershed, where an important water captation plant is situated, managed by the Nova Friburgo Water and Sewage Treatment Company LTDA (CAENF, within the 'Macaé de Cima' Ecological Reserve, Nova Friburgo-RJ. Data of daily flow and precipitation were collected

  13. Dengue: a reappraisal

    OpenAIRE

    Serufo, José Carlos; Nobre, Vandack; Rayes, Abdunnabi; Marcial, Tânia Maria; Lambertucci, José Roberto

    2000-01-01

    Os conceitos de dengue clássico, com ou sem hemorragia, e de febre hemorrágica do dengue (FHD) que, pode cursar sem fenômenos hemorrágicos, com ou sem síndrome do choque do dengue (SCD), são revistos neste artigo. As definições clássicas propostas, úteis em outros tempos, geram confusão e dificultam a tomada de decisões no momento do tratamento dos pacientes com as formas graves da doença porque deixaram de incorporar novos conceitos e avanços terapêuticos. A classificação do dengue proposta ...

  14. MODELOS GEOPOLÍTICOS: UMA INTERPRETAÇÃO DE MUNDO/Geopolitic Models: a world interpretation

    Directory of Open Access Journals (Sweden)

    Wendell Teles de Lima

    2017-12-01

    Full Text Available As teorias de interpretação da realidade geográfica do mundo contemporâneo, diante de uma perspectiva geopolítica, em sua grande maioria, são restritas a um modelo baseado no regionalismo tradicional francês, em princípio, baseado no quadro teórico interpretativo da escola francesa, no século XIX, nesse sentido, é necessário que a busca intelectual seja feita para superar este paradigma, para a interpretação dos fenômenos geográficos e geopolíticos, em função da nova realidade mundial, na perspectiva dos novos centros de poder. Portanto, a construção ainda em curso de um mundo multipolar rebate na emergência dos novos centros. Na superação desse fato, tem-se as teorias neoeurasianas e meridionalistas, buscou-se compreender essas duas teorias e em seguida uma alternativa ainda inicial proposta pela teórica das escalas geopolíticas geográficas multifunções. Os caminhos trilhados para esse objetivo foram: a organização do pensamento através da metodologia interpretativa das duas teorias, logo depois, uma interpretação de uma nova possibilidade, interpretativa de proposição geopolítica.

  15. Relato de caso: transmissão vertical de dengue Case report: vertical dengue infection

    Directory of Open Access Journals (Sweden)

    Samara L. C. Maroun

    2008-12-01

    Full Text Available OBJETIVOS: Relatar um caso de transmissão vertical de dengue ocorrido durante epidemia de 2008 pelo vírus tipo II no Rio de Janeiro e revisar a literatura sobre transmissão vertical de dengue. DESCRIÇÃO: Relatamos um caso de transmissão vertical de dengue. Recém-nascido a termo do sexo feminino, peso de nascimento de 3.940 g, foi admitida na unidade de terapia intensiva neonatal com rash cutâneo, hipoatividade e febre no quinto dia de vida. O hemograma evidenciava plaquetopenia importante (38.000 plaquetas. A mãe apresentou quadro clínico compatível com dengue 3 dias antes do parto. Foram colhidos então IgM para dengue da mãe e do recém-nascido, realizados pelo método de ELISA, sendo positivos em ambos. Dengue tipo 2 foi detectado no recém-nascido através de reação em cadeia da polimerase. COMENTÁRIOS: Este relato enfatiza a importância do pediatra estar alerta para a possibilidade de transmissão vertical de dengue iniciando precocemente o tratamento.OBJECTIVES: To report a case of vertical dengue infection in a newborn from Rio de Janeiro, Brazil, and to review the literature concerning this problem. DESCRIPTION: We report a case of vertical dengue infection. Female neonate, birth weight 3,940 g, term, was admitted to a neonatal intensive care unit on the fifth day of life with fever and erythematous rash. Her mother had had dengue fever 3 days before delivery. Her platelet count was 38,000, dropping to 15,000. She did not have any hemorrhagic episodes, including cerebral hemorrhages. Anti-dengue antibodies (IgM were positive in the mother and infant. Dengue type 2 was detected in the infant using polymerase chain reaction. COMMENTS: This report emphasizes that pediatricians should be aware of the possibility of vertical dengue infection so that early management can be instituted.

  16. Dengue in Bali: Clinical characteristics and genetic diversity of circulating dengue viruses.

    Science.gov (United States)

    Megawati, Dewi; Masyeni, Sri; Yohan, Benediktus; Lestarini, Asri; Hayati, Rahma F; Meutiawati, Febrina; Suryana, Ketut; Widarsa, Tangking; Budiyasa, Dewa G; Budiyasa, Ngurah; Myint, Khin S A; Sasmono, R Tedjo

    2017-05-01

    A high number of dengue cases are reported annually in Bali. Despite the endemicity, limited data on dengue is available for Bali localities. Molecular surveillance study was conducted to explore the clinical and virological characteristics of dengue patients in urban Denpasar and rural Gianyar areas in Bali during the peak season in 2015. A total of 205 adult dengue-suspected patients were recruited in a prospective cross-sectional study. Demographic and clinical information were obtained, and dengue screening was performed using NS1 and IgM/IgG ELISAs. Viral RNA was subsequently extracted from patients' sera for serotyping using conventional RT-PCR and Simplexa Dengue real-time RT-PCR, followed by genotyping with sequencing method. We confirmed 161 patients as having dengue by NS1 and RT-PCR. Among 154 samples successfully serotyped, the DENV-3 was predominant, followed by DENV-1, DENV-2, and DENV-4. Serotype predominance was different between Denpasar and Gianyar. Genotyping results classify DENV-1 isolates into Genotype I and DENV-2 as Cosmopolitan Genotype. The classification grouped isolates into Genotype I and II for DENV-3 and DENV-4, respectively. Clinical parameters showed no relationship between infecting serotypes and severity. We observed the genetic diversity of circulating DENV isolates and their relatedness with historical data and importation to other countries. Our data highlights the role of this tourist destination as a potential source of dengue transmission in the region.

  17. Radiation of dwarf novae

    International Nuclear Information System (INIS)

    Bruch, A.

    1987-01-01

    The nature of dwarf novae with their components white dwarf star, cool star, accretion disk, boundary layer and hot spot is investigated. It is shown that very different physical states and processes occur in the components of dwarf novae. Spectroscopical and photometrical observations are carried out. For better understanding the radiation portions of the single dwarf novae components are separated from the total electromagnetic spectrum recieved from the dwarf novae. The model assumptions are compared with the observations and verified

  18. Clinical and laboratory profile of different dengue sub types in dengue virus infection

    OpenAIRE

    Niloy Gan Chaudhuri; S. Vithyavathi; K. Sankar

    2016-01-01

    Background: Dengue infection, an arthropod-borne viral hemorrhagic fever is caused by Arbovirus of Flavivirus genus and transmitted by Aedes aegypti, Aedes albopictus. Liver involvement in dengue fever is manifested by the elevation of transaminases representing reactive hepatitis, due to direct attack of virus itself or the use of hepatotoxic drugs. The objective of the study was to investigate clinical and laboratory profile of different dengue sub type's patients admitted for dengue fever....

  19. A epidemia de dengue/dengue hemorrágico no município do Rio de Janeiro, 2001/2002 The epidemic of dengue and hemorrhagic dengue fever in the city of Rio de Janeiro, 2001/2002

    Directory of Open Access Journals (Sweden)

    Clarisse Guimarães Casali

    2004-08-01

    Full Text Available O objetivo deste estudo foi avaliar a ocorrência dos principais sinais e sintomas dos casos de dengue clássico e dengue hemorrágico na epidemia de 2001-2002 do município do Rio de Janeiro. Foram analisados os 155.242 casos notificados ao Sistema de Informações de Agravos de Notificação, desde janeiro/2001, até junho/2002; deste total, excluindo-se os ignorados, 81.327 casos foram classificados como dengue clássico e 958 como dengue hemorrágico, com um total de 54 óbitos. Avaliaram-se as variáveis referentes à sintomatologia da doença. Manifestações gerais como febre, cefaléia, prostração, mialgia, náuseas e dor retro-orbitária tiveram alta incidência tanto no dengue clássico como no dengue hemorrágico. Por outro lado, manifestações hemorrágicas e algumas de maior gravidade como choque, hemorragia digestiva, petéquias, epistaxe, dor abdominal e derrame pleural, estiveram significativamente associadas ao dengue hemorrágico. Além disso, a evolução do quadro clínico para o óbito foi 34,8 vezes maior no dengue hemorrágico que no dengue clássico (OR=34,8; IC 19,7-61,3.The following study was intended to evaluate the occurrence of typical signs and symptoms in the cases of classic dengue and hemorrhagic dengue fever, during the 2001-2002 epidemic in the city of Rio de Janeiro. The authors reviewed 155,242 cases notified to the Information System of Notification Diseases, from January/2001 to June/2002: 81,327 cases were classified as classic dengue and 958 as hemorrhagic dengue fever, with a total of 60 deaths. Common symptoms, such as fever, headache, prostration, myalgia, nausea and retro-orbital pain, had a high incidence in both classic and hemorrhagic dengue fever. On the other hand, hemorrhagic signs and other signs of severe disease, such as shock, gastrointestinal bleeding, petechiae, epistaxis, abdominal pain and pleural effusion, were strongly associated to hemorrhagic dengue fever. Besides, the occurrence

  20. Liquens brasileiros: novas descobertas evidenciam a riqueza no Norte e Nordeste do país

    Directory of Open Access Journals (Sweden)

    Marcela Eugenia da Silva Cáceres

    2014-10-01

    Full Text Available A maioria das espécies não descritas de fungos é esperada em áreas pouco estudadas, como as florestas tropicais ou habitats pouco explorados como fungos que vivem em insetos, plantas, ou liquens. O Filo Ascomycota apresenta o maior número de espécies dentro do Reino Fungi, sendo que cerca da metade destas espécies são liquenizadas, ou seja, associam-se a algas e/ou cianobactérias e formam os liquens. Estes fungos liquenizados, de maneira geral, têm sido muito pouco estudados no Norte e Nordeste brasileiros, no que diz respeito à sua taxonomia e ecologia. Recentemente, estudos mais completos sobre a diversidade de liquens em remanescente de Mata Atlântica e em algumas áreas da Amazônia resultaram no registro de uma grande quantidade de espécies novas para a ciência, reforçando a importância de uma caracterização mais acurada da biodiversidade de uma área para favorecer à sua conservação. No âmbito do projeto Sisbiota, foi realizado um extenso inventário de espécies de liquens corticícolas crostosos e microfoliosos no estado de Rondônia, representando a Floresta Amazônia, e no estado de Sergipe, que apresenta apenas pequenos remanescentes de Mata Altântica. Os resultados obtidos evidenciam a riqueza destas duas áreas, nas suas devidas proporções, visto que em ambas foi encontrado um número significativo de novas espécies para ciência, com 75 espécies publicadas para Rondônia, e 10 espécies novas para Sergipe. Com isso, atualmente, o número de espécies conhecidas para Rondônia passou de 31 para 502, sendo apresentados aqui 104 novos registros para o estado, sendo 10 novos registros para o Brasil e sete para o hemisfério sul.

  1. Vendredi ou Les Limbes du Pacifique: uma nova perspectiva do individualismo moderno na sociedade contemporânea = Vendredi ou Les Limbes du Pacifique: a new perspective of modern individualism in contemporary society

    Directory of Open Access Journals (Sweden)

    Jussara da Silva Rodrigues

    2013-01-01

    Full Text Available Considerado pelo crítico de literatura Ian Watt como um dos ‘mitos do individualismo moderno’, As Aventuras de Robinson Crusoe, de Daniel Defoe (1719, é um livro que exerceu e exerce grande influência no imaginário ocidental. Seu sucesso rendeu-lhe inúmeras reescrituras, conhecidas como ‘robinsoníadas’. Vendredi ou Les Limbes du Pacifique1, escrito em 1967 pelo francês Michel Tournier, é um dos intertextos mais ricos surgidos desde então. A adoção de uma perspectiva completamente nova rompe com o paradigma do homem branco civilizado e dota o texto de originalidade. Na nova versão, o individualismo de Robinson assume um caráter mais condizente com o pensamento da sociedade contemporânea. Este artigo busca, por meio de uma análise comparativa e de um estudo dos símbolos, ressaltar o potencial de Vendredi como mito do individualismo moderno na sociedade contemporânea.Considered by the critic of literature Ian Watt as one of the ‘myths of modern individualism’, The Adventures of Robinson Crusoe by Daniel Defoe (1719 is a book that exerted and exerts great influence in the occidental imagination. Its great success rendered it numerous rewritings, known as robinsonades. Vendredi ou Les Limbes du Pacifique written in 1967 by the French Michel Tournier, is one of the richest intertexts ever emerged since then. The adoption of a completely new perspective breaks with the paradigm of the white civilized man providing the originality of the text. In the new version, the individualism of Robinson gets role more consistent to the contemporary society thought. This article aims to emphasize Vendredi potential as a myth of the modern individualism in contemporary society through its symbols and a comparative analysis.

  2. Post dengue neurological complication

    Directory of Open Access Journals (Sweden)

    Hizlinda Tohid

    2015-12-01

    Full Text Available Dengue infection is highly endemic in many tropical countries including Malaysia. However, neurological complications arising from dengue infection is not common; Gullain–Barre syndrome (GBS is one of these infrequent complications. In this paper, we have reported a case in which a 39-year-old woman presented with a neurological complication of dengue infection without typical symptoms and signs of dengue fever. She had a history of acute gastroenteritis (AGE followed by an upper respiratory tract infection (URTI weeks prior to her presentation rendering GBS secondary to the post viral URTI and AGE as the most likely diagnosis. Presence of thrombocytopenia was the only clue for dengue in this case.

  3. Projeto Relesa-Elanem: uma Nova Proposta Metodológica de Índices e Indicadores para Avaliação da Qualidade Ambiental

    Directory of Open Access Journals (Sweden)

    A. Cendrero

    2002-11-01

    Full Text Available O objetivo principal do projeto RELESA/ELANEM foi elaborar uma nova proposta metodológica para a obtenção de índices e indicadores quantitativos de avaliação da qualidade ambiental que seja aplicável a diferentes regiões e ofereça a possibilidade de obter resultados quantitativamente comparáveis. A proposta remete em testar um procedimento capaz de medir a qualidade ambiental e possíveis relações estabelecidas com as pressões derivadas de ações humanas, assim como o nível de resposta da sociedade para mudanças na condição do ambiente, objetivando a sustentabilidade dos recursos naturais. A espacialização das informações dá-se através da identificação, mapeamento e análise de Unidades Ambientais Integradas, delimitadas com atributos distintos, isto é, de acordo com as formas de uso e ocupação de cada ambiente. É neste contexto que a componente geomorfológica assume importância fundamental na delimitação destas unidades.

  4. La epidemiología del dengue y del dengue hemorrágico en Santiago de Cuba, 1997 The epidemiology of dengue and dengue hemorrhagic fever in Santiago de Cuba, 1997

    Directory of Open Access Journals (Sweden)

    Luis Valdés

    1999-07-01

    Full Text Available En 1977, Cuba informó de su primera epidemia de dengue, durante la cual se registraron más de 500 000 casos de fiebre del dengue causados por el serotipo 1 del virus. En 1981, se produjo una gran epidemia de dengue hemorrágico causada por el serotipo 2. Esa vez se notificaron 344 203 casos en total, 10 312 casos clínicos de dengue hemorrágico y 158 defunciones, de las cuales 101 correspondieron a niños. Por medio de una búsqueda activa con confirmación de laboratorio, en el municipio de Santiago de Cuba de la provincia del mismo nombre se detectó precozmente en enero de 1997 la reintroducción del dengue, específicamente del virus del tipo 2, genotipo Jamaica. En este trabajo se presentan los aspectos epidemiológicos de mayor interés referentes a esa epidemia. Se notificaron 3 012 casos confirmados por serología, 205 clasificados como fiebre hemorrágica del dengue/síndrome de choque del dengue, de los cuales 12 fallecieron (todos adultos. La infección secundaria por virus del dengue fue uno de los principales factores de riesgo en el desarrollo de dengue hemorrágico y 98% de los casos, así como 92% de los fallecidos, manifestaron una respuesta de tipo secundario. Por primera vez se observó la posibilidad de contraer dengue hemorrágico en personas con una infección secundaria de 16 a 20 años después de la primera infección. Pertenecer a la raza blanca fue otro factor de riesgo de importancia, tal como se había observado desde la epidemia de 1981. En la última epidemia se demostró que la llamada “alerta de fiebre” no es útil para la detección temprana de una epidemia. Las medidas tomadas por las autoridades sanitarias del país evitaron la extensión de la epidemia a otros municipios que estaban infestados por Aedes aegypti.A dengue epidemic that Cuba reported in 1997 registered more than 500 000 cases of dengue fever produced by viral serotype 1. In 1981, there was an epidemic of dengue hemorrhagic fever produced by

  5. Is drought helping or killing dengue? Investigation of spatiotemporal relationship between dengue fever and drought

    Science.gov (United States)

    Lee, Chieh-Han; Yu, Hwa-Lung

    2015-04-01

    Dengue Fever is a vector-borne disease that is transmitted between human and mosquitos in tropical and sub-tropical regions. Previous studies have found significant relationship between the epidemic of dengue cases and climate variables, especially temperature and precipitation. Besides, the natural phenomena (e.g., drought) are considered that significantly drop the number of dengue cases by killing vector's breeding environment. However, in Kaohsiung City, Taiwan, there are evidences that the temporal pattern of dengue is correlated to drought events. Kaohsiung City experienced two main dengue outbreaks in 2002 and 2014 that both years were confirmed with serious drought. Especially in 2014, Kaohsiung City was suffered from extremely dengue outbreak in 2014 that reported the highest number of dengue cases in the history. This study constructs the spatiotemporal model of dengue incidences and index of drought events (Standardized Precipitation Index, SPI) based on the distributed lag nonlinear model (DLNM). Other meteorological measures are also included in the analysis.

  6. Cronótopos de uma nação distópica: o nascimento da "dependência" no México porfiriano tardio

    Directory of Open Access Journals (Sweden)

    Claudio Lomnitz

    2009-04-01

    Full Text Available Este artigo desenvolve uma nova abordagem sobre a antropologia e a história de fronteiras nacionais. Ele propõe uma tipologia e uma caracterização fenomenológica de duas formas de se atravessar a fronteira que surgiram paralelamente a uma nova relação de dependência econômica e política entre o México e os Estados Unidos da América no final do século XIX. Tais novas modalidades de se atravessar a fronteira envolvem o desenvolvimento de novos "cronótopos", ou seja, novas e concorrentes matrizes espaços-temporais que foram utilizadas para enquadrar a relação entre o México e os EUA. Este artigo analisa a qualidade, a natureza e o preço destas formas alternativas de historicidade por intermédio de uma análise detalhada de dois textos jornalísticos cruciais: a entrevista do General Porfírio Diaz por James Creelman (1908 e a reportagem de Kenneth Turner sobre a escravidão mexicana (1910.This paper develops a novel approach to anthropology and history of international borders. It proposes a typology and a phenomenological characterization of two kinds of border crossings that emerged alongside the new relationship of economic and political dependency that developed between México and the United States in the last quarter of the 19th century. The new border crossings involved the development of new 'chronotopes', in other words new and competing spatial-temporal matrices, used to frame the relationship between México and the United States. This paper analyzes the quality, nature and stakes of these alternative forms of historicity by way of a close case study of two pivotal journalistic texts: James Creelman's (1908 interview of General Porfírio Diaz, and John Kenneth Turner's (1910 reportage and exposé of Mexican slavery.

  7. Humor na Internet: trabalhadores utilizam nova estratégia para protestar contra demissões e terceirizações

    Directory of Open Access Journals (Sweden)

    Raquel Alves Furtado

    2014-03-01

    Full Text Available O objetivo neste artigo é analisar de que forma trabalhadores de uma empresa utilizaram o humor para manifestar-se contra demissões e terceirizações ocorridas nos anos 2000. Enquanto ela pregava a implantação de uma nova maneira de ser da empresa, que seria mais moderna, transparente e participativa, os trabalhadores produziram dois vídeos, postados no YouTube, para contar outra história, ridicularizar o discurso oficial e protestar. Ao combinar a utilização do humor com a Internet, os trabalhadores demonstraram sua capacidade de atualizar-se e encontrar novas formas de manifestar-se diante das situações vividas por eles, o que parece ter ampliado seu poder na luta simbólica. Embora as demissões e terceirizações não tenham sido revertidas, a "nova" gestão foi substituída pelos acionistas após dois anos de mandato. Os vídeos foram analisados a partir da técnica de análise de discurso de base francesa, que considera textos orais e escritos como discursos, e com o suporte da semiótica para a análise das imagens que acompanham a letra. A análise indica que os trabalhadores denunciam o rompimento do contrato psicológico estabelecido pela empresa, que se baseava na estabilidade do emprego. Os autores dos vídeos associam a empresa a uma figura feminina, ora mãe, ora amante, e o trabalho nela como algo que estava predestinado em sua vida. Eles demonstram o sentimento de abandono e traição, condizente com esse tipo de situação.

  8. Dengue and Calcium

    OpenAIRE

    Shivanthan, Mitrakrishnan C; Rajapakse, Senaka

    2014-01-01

    Dengue is potentially fatal unless managed appropriately. No specific treatment is available and the mainstay of treatment is fluid management with careful monitoring, organ support, and correction of metabolic derangement. Evidence with regards to the role of calcium homeostasis in dengue is limited. Low blood calcium levels have been demonstrated in dengue infection and hypocalcemia maybe more pronounced in more severe forms. The cause of hypocalcemia is likely to be multifactorial. Calcium...

  9. Controlling dengue with vaccines in Thailand.

    Directory of Open Access Journals (Sweden)

    Dennis L Chao

    Full Text Available Dengue is a mosquito-borne infectious disease that constitutes a growing global threat with the habitat expansion of its vectors Aedes aegyti and A. albopictus and increasing urbanization. With no effective treatment and limited success of vector control, dengue vaccines constitute the best control measure for the foreseeable future. With four interacting dengue serotypes, the development of an effective vaccine has been a challenge. Several dengue vaccine candidates are currently being tested in clinical trials. Before the widespread introduction of a new dengue vaccine, one needs to consider how best to use limited supplies of vaccine given the complex dengue transmission dynamics and the immunological interaction among the four dengue serotypes.We developed an individual-level (including both humans and mosquitoes, stochastic simulation model for dengue transmission and control in a semi-rural area in Thailand. We calibrated the model to dengue serotype-specific infection, illness and hospitalization data from Thailand. Our simulations show that a realistic roll-out plan, starting with young children then covering progressively older individuals in following seasons, could reduce local transmission of dengue to low levels. Simulations indicate that this strategy could avert about 7,700 uncomplicated dengue fever cases and 220 dengue hospitalizations per 100,000 people at risk over a ten-year period.Vaccination will have an important role in controlling dengue. According to our modeling results, children should be prioritized to receive vaccine, but adults will also need to be vaccinated if one wants to reduce community-wide dengue transmission to low levels.

  10. Controlling Dengue with Vaccines in Thailand

    Science.gov (United States)

    Chao, Dennis L.; Halstead, Scott B.; Halloran, M. Elizabeth; Longini, Ira M.

    2012-01-01

    Background Dengue is a mosquito-borne infectious disease that constitutes a growing global threat with the habitat expansion of its vectors Aedes aegyti and A. albopictus and increasing urbanization. With no effective treatment and limited success of vector control, dengue vaccines constitute the best control measure for the foreseeable future. With four interacting dengue serotypes, the development of an effective vaccine has been a challenge. Several dengue vaccine candidates are currently being tested in clinical trials. Before the widespread introduction of a new dengue vaccine, one needs to consider how best to use limited supplies of vaccine given the complex dengue transmission dynamics and the immunological interaction among the four dengue serotypes. Methodology/Principal Findings We developed an individual-level (including both humans and mosquitoes), stochastic simulation model for dengue transmission and control in a semi-rural area in Thailand. We calibrated the model to dengue serotype-specific infection, illness and hospitalization data from Thailand. Our simulations show that a realistic roll-out plan, starting with young children then covering progressively older individuals in following seasons, could reduce local transmission of dengue to low levels. Simulations indicate that this strategy could avert about 7,700 uncomplicated dengue fever cases and 220 dengue hospitalizations per 100,000 people at risk over a ten-year period. Conclusions/Significance Vaccination will have an important role in controlling dengue. According to our modeling results, children should be prioritized to receive vaccine, but adults will also need to be vaccinated if one wants to reduce community-wide dengue transmission to low levels. PMID:23145197

  11. Tri-phasic fever in dengue fever.

    Science.gov (United States)

    D, Pradeepa H; Rao, Sathish B; B, Ganaraj; Bhat, Gopalakrishna; M, Chakrapani

    2018-04-01

    Dengue fever is an acute febrile illness with a duration of 2-12 days. Our observational study observed the 24-h continuous tympanic temperature pattern of 15 patients with dengue fever and compared this with 26 others with fever due to a non-dengue aetiology. A tri-phasic fever pattern was seen among two-thirds of dengue fever patients, but in only one with an inflammatory disease. One-third of dengue fever patients exhibited a single peak temperature. Continuous temperature monitoring and temperature pattern analysis in clinical settings can aid in the early differentiation of dengue fever from non-dengue aetiology.

  12. O cinema do futuro: Entre novas e tradicionais tecnologias, entre a morte e a reinvenção

    Directory of Open Access Journals (Sweden)

    Julio Bezerra

    2010-03-01

    Full Text Available O cinema não é mais a experiência audiovisual matriz em nossa “sociedade das imagens”. Essa enorme rede heterogênea que vai se constituindo no terreno da produção e circulação de imagens-sons tem nos mostrado que é preciso mudar a nossa percepção do lugar do cinema entre os demais dispositivos. O objetivo deste texto é pensar o cinema em suas relações com o que vem sendo chamado de novas mídias. Nossa posição se aproxima de certa maneira de Phillipe Dubois: afirmando o cinema como uma espécie de referência fundante para todo o audiovisual sem ressentimentos e/ou opiniões fechadas com relação às novas tecnologias. Neste caminho, passamos invariavelmente por algumas falsas questões, pela melancólica idéia da “morte do cinema”, pelo surgimento de uma novíssima cinefilia digital e rizomática, por um cinema contemporâneo pra lá de impuro.

  13. Vírus dengue em larvas de Aedes aegypti e sua dinâmica de infestação, Roraima, Brasil Virus dengue en larvas de Aedes aegypti y su dinámica de infestación, Roraima, Brasil Dengue virus in Aedes aegypti larvae and infestation dynamics in Roraima, Brazil

    Directory of Open Access Journals (Sweden)

    Julianna Dias Zeidler

    2008-12-01

    Full Text Available OBJETIVO: Identificar a presença do vírus dengue em formas larvais de Aedes aegypti e relacionar a presença do vetor com índice pluviométrico e número de casos de dengue. MÉTODOS: Dezoito domicílios foram selecionados aleatoriamente para coleta de ovos em um bairro da cidade de Boa Vista (RR. Foram instaladas duas ovitrampas por domicílio e removidas após uma semana, mensalmente, de novembro de 2006 a maio de 2007. Foram calculados o índice de positividade de ovitrampa e o índice de densidade dos ovos. Após eclosão de 1.422 ovos coletados, foram formados 44 pools de no máximo 30 larvas para teste de presença do vírus dengue por meio de RT-PCR e hemi-nested PCR. O índice de incidência de dengue no período foi correlacionado com a precipitação pluvial. A associação entre essas variáveis e número de ovos coletados foi analisada pelo coeficiente de Pearson. RESULTADOS: Nenhum dos pools apresentou positividade para o vírus dengue, apesar do bairro ter apresentado elevados índices de incidência de dengue no período estudado. A densidade da população de Ae. aegypti aumentou conforme a pluviosidade, mas não apresentou correlação com índices de incidência de casos de dengue. CONCLUSÕES: Os resultados sugerem que a transmissão transovariana do vírus em mosquitos ocorre a uma freqüência muito baixa e por isso sua persistência em meio urbano pode não depender desse fenômeno. A população do mosquito aumentou no período de chuvas devido à formação de criadouros; a não-correlação com o índice de incidência de dengue deve-se à possibilidade desse dado ser subestimado em períodos de epidemia.OBJETIVO: Identificar la presencia del virus dengue en forma larvales de Aedes aegypti y relacionar la presencia del vector con índice pluviométrico y número de casos de dengue en el período estudiado. MÉTODOS: Dieciocho domicilios fueron seleccionados al azar para colectar huevos en una urbanización de la

  14. Experienciando o letramento digital: sistematização de uma pesquisa-ação online

    Directory of Open Access Journals (Sweden)

    Maria Conceição Alves de LIMA

    2008-12-01

    Full Text Available O surgimento da Internet e da Web ocasionaram uma ruptura com o tipo de comunicação estabelecido pela escrita impressa e inauguraram a “revolução digital”. Estar fora dessa comunidade digital significa estar excluído da nova Sociedade do Conhecimento, razão pela qual uma das necessidades mais urgentes dos não-incluídos digitais é obter essa nova espécie de letramento. Buscando, pois, acompanhar essas transformações tecnológicas, desenvolvemos uma atividade-piloto de pesquisa-intervenção, a partir da execução online de um projeto voltado ao letramento digital, destinado aos alunos do Curso de Letras da Unidade Universitária de Nova Andradina – Universidade Estadual de Mato Grosso do Sul, UEMS, cujos objetivos específicos visavam à conscientização da necessidade da inclusão digital e à iniciação nesse tipo de letramento. O processo de intervenção aconteceu, basicamente, sob a forma de e-learning, através da sala de aula virtual TELEDUC. Quanto à observação/análise/inferência, além do acompanhamento das atividades através do TELEDUC, foram usadas estratégias de reuniões presenciais com tutores e participantes. A execução dessa pesquisa-intervenção permitiu-nos uma gama considerável de observações e reflexões sobre alguns aspectos tecnológicos, pedagógicos, socioculturais e estratégicos dessa atividade, possibilitando-nos avaliar não somente suas possibilidades educativas, mas também as necessidades operacionais vinculadas à sua implementação.

  15. Experienciando o letramento digital: sistematização de uma pesquisa-ação online

    Directory of Open Access Journals (Sweden)

    Maria Conceição Alves de LIMA

    2013-10-01

    Full Text Available O surgimento da Internet e da Web ocasionaram uma ruptura com o tipo de comunicação estabelecido pela escrita impressa e inauguraram a “revolução digital”. Estar fora dessa comunidade digital significa estar excluído da nova Sociedade do Conhecimento, razão pela qual uma das necessidades mais urgentes dos não-incluídos digitais é obter essa nova espécie de letramento. Buscando, pois, acompanhar essas transformações tecnológicas, desenvolvemos uma atividade-piloto de pesquisa-intervenção, a partir da execução online de um projeto voltado ao letramento digital, destinado aos alunos do Curso de Letras da Unidade Universitária de Nova Andradina – Universidade Estadual de Mato Grosso do Sul, UEMS, cujos objetivos específicos visavam à conscientização da necessidade da inclusão digital e à iniciação nesse tipo de letramento. O processo de intervenção aconteceu, basicamente, sob a forma de e-learning, através da sala de aula virtual TELEDUC. Quanto à observação/análise/inferência, além do acompanhamento das atividades através do TELEDUC, foram usadas estratégias de reuniões presenciais com tutores e participantes. A execução dessa pesquisa-intervenção permitiu-nos uma gama considerável de observações e reflexões sobre alguns aspectos tecnológicos, pedagógicos, socioculturais e estratégicos dessa atividade, possibilitando-nos avaliar não somente suas possibilidades educativas, mas também as necessidades operacionais vinculadas à sua implementação.

  16. O Transito e o Turismo na Cidade de caldas Novas - GO / TRAFFIC AND TOURISM IN THE CALDAS NOVAS CITY - BRAZIL

    Directory of Open Access Journals (Sweden)

    Norma Urban Gomes

    2010-05-01

    Full Text Available Resumo: Este trabalho tem como objetivo, mostrar a relação intrínseca entre o trânsito e o turismo na cidade de Caldas Novas – GO. Deste modo, para estudarmos o trânsito e seus elementos, bem como todos os fatores positivos e negativos do mesmo na cidade teremos necessariamente que falar a respeito do turismo, pois é partir dessa premissa que se molda a questão da Geografia dos Transportes em Caldas Novas,cidade esta que se destaca pelo apelo turístico de suas águas termais. A Geografia se preocupa com o inter-relacionamento ambiental e humano em um contexto espacial, e Geografia dos Transportes é o estudo dos sistemas de transportes e seus impactos espaciais. Os meios de transporte são essenciais em uma cidade turística, pois o fluxo de pessoas, bens e serviços dependem substancialmente da condição de circulação. Esse trabalho justifica-se pela necessidade de compreender e avaliar a situação do trânsito na cidade de Caldas Novas nos períodos de alta temporada, quando a cidade sofre intensa movimentação turística,causando um grande acumulo de veículos e pessoas nas vias de circulação. Isso dificulta além obviamente da circulação das pessoas como a circulação de bens e serviços essenciais para que a atividade turística se desenvolva satisfatoriamente. O estudo dos transportes é, sobretudo, multidisciplinar por natureza, e algumas vezes também interdisciplinar.

  17. Spectral evolution of Nova V400 Per (1974) and Nova V373 Sct (1975)

    International Nuclear Information System (INIS)

    Rosino, L.

    1978-01-01

    Photographic and spectroscopic observations of the two galactic novae, V400 Per and V373 Sct, which appeared in 1974 and 1975, have been carried out at Asiago. The light curves of the two novae were characterized by the presence of brightness oscillations during the early decline. The spectral evolution was quite normal: the spectra showed at first, over a relatively strong continuum, wide emission bands of moderate excitation, accompanied by blueshifted absorptions, with radial velocities of - 1760 kms -1 (Nova Per) and - 1260 kms -1 (Nova Sct). Later, after the novae entered the nebular stage, the continuum weakened, the absorption disappeared and the novae displayed the usual emission spectrum, with permitted and forbidden lines of high excitation ([O III], N III, He I, He II). Forbidden lines of Fe VI and Fe VII - and in Nova Sct, also Fe X and A X - were present for a time, but they soon disappeared, so that at the end the spectrum was dominated by the [O III] nebular lines, even stronger than Hα. (Auth.)

  18. Desvelamento do limiar discursivo de uma marca global em uma cultura local

    Directory of Open Access Journals (Sweden)

    Flávia Zimmerle da Nóbrega Costa

    Full Text Available Com o advento da globalização inicia-se uma nova forma de convivência entre as sociedades, cuja possibilidade contribui para gerar um emaranhado campo de cruzamentos culturais e permite o estabelecimento de valores universais em meios locais. Este contexto, aliado à cultura de massas, promoveu as marcas a símbolos culturais complexos e globais. Inspirados no projeto arqueológico de Michel Foucault, elegemos uma marca global para realizar um estudo de caso fotoetnográfico de práticas cotidianas mundanas. Este processo nos possibilitou realizar a análise por meio de um trabalho de ordenação, definição e descrição, elaborado no interior do campo discursivo, permitindo que os resultados revelassem descrições enunciativas pautadas nas ações de marketing da marca. Estas nos revelaram funções e suas relações nos permitiram decifrar as regras sob as quais essas se encontravam regidas. A análise nos revelou o limiar relacional entre as culturas global e local e nos possibilitou desvelar as relações existentes nesta teia discursiva, possibilitando a compreensão de como uma marca transnacional se estabelece numa cultura local reproduzindo a cultura global. Neste sentido, apontamos alguns caminhos para reflexão acerca das sociedades ocidentais no contemporâneo.

  19. 1960: Nova Iorque, Londres, Paris e São Paulo

    OpenAIRE

    Shitara, Mitsuko

    2010-01-01

    Esta dissertação procura analisar a evolução da moda e as influências que sofreu e exerceu sobre a sociedade de consumo nos anos 1960. Após fazer um resgate das condições que conduziram o desenvolvimento da moda até a década de 1960, ilustradas pela evolução do design e das formas de produção, bem como o surgimento de uma nova e importante categoria de consumidor os jovens -, é registrada a forma de consumo de roupas, substituindo o elitismo da alta costura pela democracia do prêt-à-porter....

  20. Violência contra idosos: uma questão nova?

    Directory of Open Access Journals (Sweden)

    Ana Paula R. Amadio Sanches

    Full Text Available O envelhecimento da população mundial é um fato concreto e de conhecimento público. O Brasil inicia seu processo de transição demográfica seguindo o padrão mundial: o aumento do número de idosos com possibilidade de atingir elevadas faixas etárias, o que traz a necessidade de pesquisas nesse campo, devido à demanda apresentada por essa nova parcela da população. A questão da violência doméstica contra idosos tem se ampliado e sugere necessidade de maior campo de investigação nessa área, dado o risco suposto ao qual essa população mais idosa está submetida. O objetivo deste artigo é verificar os estudos relacionados ao tema já realizados no Brasil e em diferentes países, com enfoque epidemiológico. O trabalho apresenta diversos pontos de abordagem da violência contra idosos, considerando questões relacionadas à cultura do envelhecimento, ações de políticas públicas, atuação de equipes de saúde, definição do termo abordado, aspectos legais e éticos da violência contra o idoso. Tal estudo permite ao pesquisador analisar os diferentes aspectos que envolvem a temática, demonstrando a necessidade de pesquisas específicas direcionadas ao tema.

  1. Dengue fever (image)

    Science.gov (United States)

    Dengue fever, or West Nile fever, is a mild viral illness transmitted by mosquitoes which causes fever, ... second exposure to the virus can result in Dengue hemorrhagic fever, a life-threatening illness.

  2. Cultura material, oralidade e simbologia. Existe uma filosofia em África?

    Directory of Open Access Journals (Sweden)

    Vicente Geraldo Amâncio Diniz Oliveira

    2003-10-01

    Full Text Available Considerando-se o modus vivendi africano, não há dúvida de que há uma visão de mundo que poderia se configurar como “Filosofia”. A valorização, tanto da cultura material como da riqueza espiritual e princípios éticos dos diversos grupos que compõem o mosaico cultural africano, evidencia o legado de gerações passadas às novas gerações. Mesmo não havendo uma sistematização do conhecimento, haveria, pois, uma filosofia de vida em que a herança cultural recebida é continuamente reelaborada e confrontada com a dinamicidade da realidade circundante, que se mostra em contínuo vir-a-ser.

  3. Manifestações mucocutâneas da dengue Mucocutaneous manifestations of dengue

    Directory of Open Access Journals (Sweden)

    Omar Lupi

    2007-08-01

    Full Text Available Dengue é doença viral sistêmica que ocorre de forma epidêmica em áreas tropicais e subtropicais da Ásia, Américas e África. O vírus da dengue pertence ao gênero Flavivirus e à família Flaviviridae (arbovírus do grupo B. Aedes aegypti é o principal vetor e verdadeiro reservatório. A febre na dengue clássica persiste por período de dois a cinco dias com cefaléia intensa, mialgia, artralgia e dor retro-orbital. Alterações cutâneas incluem diversos achados como erupção morbiliforme que pode ser pruriginosa e que gera descamação residual, algumas manifestações hemorrágicas discretas como epistaxe, petéquias e sangramento gengival. Extravasamento capilar de plasma é responsável pela hemoconcentração e trombocitopenia observadas e que caracterizam a dengue hemorrágica. Manifestações cutâneas da dengue hemorrágica incluem lesões hemorrágicas disseminadas como petéquias e equimoses, mas também instabilidade hemodinâmica com pulso filiforme, pressão arterial convergente, extremidades frias, confusão mental e choque.Dengue fever is a systemic viral disease that occurs epidemically in tropical and subtropical regions of Asia, Americas and Africa. The dengue virus belongs to the genus Flavivirus of the family Flaviviridae (group B arbovirus. Aedes aegypti is the major vector and the true reservoir for the virus. Classic dengue fever lasts for two-five days, with severe headache, intense myalgia, arthralgia and retro-orbital pain. Cutaneous alterations include several findings such as a diffuse morbilliform rash that may be pruritic and heals with desquamation, and minor bleeding phenomena such as epistaxis, petechiae, and gingival bleeding. Diffuse capillary leakage of plasma is responsible for the hemoconcentration and thrombocytopenia that characterize dengue hemorrhagic fever. Cutaneous manifestations of dengue hemorrhagic fever include many disseminated hemorrhagic lesions such as petechiae and ecchymoses, but

  4. Nova tecnica de estimacao de fasores na presenca de decaimento DC exponencial em sistemas de potencia

    NARCIS (Netherlands)

    Vianello, R.; Silva, L.R.M.; Duque, C.A.; Serqueira, A.S.; Ribeiro, M.V.; Silveira, P.M.; Ribeiro, P.F.

    2009-01-01

    O presente trabalho apresenta uma nova metodologia de estimação de fasores na presença de decaimento DC exponencial e de harmônicos ímpares no sinal. As estimações são realizadas em meio ciclo mais três amostras da componente fundamental do sistema. O método é baseado na estimação dos parâmetros do

  5. MedCase: uma ferramenta online para estudo de casos clínicos = Medcase: an online tool for medical learning

    Directory of Open Access Journals (Sweden)

    Losekann, Alexandre

    2007-01-01

    Conclusões: considerando as novas tendências na área da educação, o MedCase representa uma nova proposta para a comunidade médica acadêmica, ao viabilizar a união de conhecimento científico com ambientes tecnológicos. Acreditamos que este programa será muito útil no ensino médico em diferentes estágios de formação, desde alunos debutantes até professores de medicina

  6. Novae news

    CERN Document Server

    2012-01-01

    As announced in the previous Bulletin, Novae has opened a new snack bar on the Flagstaff car park, just a few metres from CERN's reception area (Building 33).   Just a few metres from the CERN Reception, the new Novae snack point welcomes visitors and CERNois. Opening hours Currently: Monday to Friday, 8 a.m. to 4 p.m. From September: Monday to Friday, 7:45 a.m. to 5 p.m.; Saturdays from 8 a.m. to 2 p.m. The snack bar selection includes breakfast, starting at 2.70 CHF, cold dishes from 5 CHF, and hot dishes from 6 CHF.   Novae has also installed a 24-hour-a-day food vending machine in the CERN hostel (Building 39) and in Building 13. You can buy pasta and cooked dishes for 6.50 CHF to 8 CHF. In addition, a groceries vending machine has been installed in the main building, just across from the news kiosk. Nearly 60 different items are available around the clock. Finally, Novae has introduced a new payment system in several buildings on the Meyrin site. It accepts credit ca...

  7. Ensemble method for dengue prediction.

    Science.gov (United States)

    Buczak, Anna L; Baugher, Benjamin; Moniz, Linda J; Bagley, Thomas; Babin, Steven M; Guven, Erhan

    2018-01-01

    In the 2015 NOAA Dengue Challenge, participants made three dengue target predictions for two locations (Iquitos, Peru, and San Juan, Puerto Rico) during four dengue seasons: 1) peak height (i.e., maximum weekly number of cases during a transmission season; 2) peak week (i.e., week in which the maximum weekly number of cases occurred); and 3) total number of cases reported during a transmission season. A dengue transmission season is the 12-month period commencing with the location-specific, historical week with the lowest number of cases. At the beginning of the Dengue Challenge, participants were provided with the same input data for developing the models, with the prediction testing data provided at a later date. Our approach used ensemble models created by combining three disparate types of component models: 1) two-dimensional Method of Analogues models incorporating both dengue and climate data; 2) additive seasonal Holt-Winters models with and without wavelet smoothing; and 3) simple historical models. Of the individual component models created, those with the best performance on the prior four years of data were incorporated into the ensemble models. There were separate ensembles for predicting each of the three targets at each of the two locations. Our ensemble models scored higher for peak height and total dengue case counts reported in a transmission season for Iquitos than all other models submitted to the Dengue Challenge. However, the ensemble models did not do nearly as well when predicting the peak week. The Dengue Challenge organizers scored the dengue predictions of the Challenge participant groups. Our ensemble approach was the best in predicting the total number of dengue cases reported for transmission season and peak height for Iquitos, Peru.

  8. Ensemble method for dengue prediction.

    Directory of Open Access Journals (Sweden)

    Anna L Buczak

    Full Text Available In the 2015 NOAA Dengue Challenge, participants made three dengue target predictions for two locations (Iquitos, Peru, and San Juan, Puerto Rico during four dengue seasons: 1 peak height (i.e., maximum weekly number of cases during a transmission season; 2 peak week (i.e., week in which the maximum weekly number of cases occurred; and 3 total number of cases reported during a transmission season. A dengue transmission season is the 12-month period commencing with the location-specific, historical week with the lowest number of cases. At the beginning of the Dengue Challenge, participants were provided with the same input data for developing the models, with the prediction testing data provided at a later date.Our approach used ensemble models created by combining three disparate types of component models: 1 two-dimensional Method of Analogues models incorporating both dengue and climate data; 2 additive seasonal Holt-Winters models with and without wavelet smoothing; and 3 simple historical models. Of the individual component models created, those with the best performance on the prior four years of data were incorporated into the ensemble models. There were separate ensembles for predicting each of the three targets at each of the two locations.Our ensemble models scored higher for peak height and total dengue case counts reported in a transmission season for Iquitos than all other models submitted to the Dengue Challenge. However, the ensemble models did not do nearly as well when predicting the peak week.The Dengue Challenge organizers scored the dengue predictions of the Challenge participant groups. Our ensemble approach was the best in predicting the total number of dengue cases reported for transmission season and peak height for Iquitos, Peru.

  9. THROMBOCYTOPENIA IN DENGUE HAEMORRHAGIC FEVER

    Directory of Open Access Journals (Sweden)

    I Wayan Putu Sutirta-Yasa

    2013-04-01

    Full Text Available The incidence and geographical distribution of dengue has gradually increased during the past decade. Today, dengue is considered one of the most important arthropod-borne viral diseasases in humans in term of morbidity and mortality. Dengue infection   a potential life-threatening dengue hemorrhagic fever (DHF / dengue shock syndrome(DSS, characterized by thrombocytopenia and increased vascular permiability. Thrombocytopenia causes bleeding, but in   DHF patients with thrombocytopenia do not always develop bleeding manifestation. The pathogenesis of thrombocytopenia are not cleared. Multiple factors  may be involved in the machanisms leading to thrombocytopenia in DHF/DSS patients.

  10. Dengue and dengue hemorrhagic fever in the Americas: lessons and challenges.

    Science.gov (United States)

    Guzman, María G; Kouri, Gustavo

    2003-05-01

    The incidence of dengue and dengue hemorrhagic fever (DF/DHF) has increased significantly over the last decades. Yearly, an estimated 50-100 million cases of DF and about 250000-500000 cases of DHF occur worldwide. The epidemiological situation in Latin America now resembles that in Southeast Asia. Here, the main clinical, epidemiological and virological observations in the American region are presented and compared with those previously reported from Southeast Asia. During 2002, more than 30 Latin American countries reported over 1000000 DF cases. DHF occurred in 20 countries with more than 17000 DHF cases, including 225 fatalities. The co-circulation of multiple serotypes has been reported from many countries. In the Americas, DHF is observed both in children and adults; secondary infection by a different dengue virus serotype has been confirmed as an important risk factor for this severe form of the disease. However, some new risk factors such as the interval of dengue virus infections and the ethnicity and underlying chronic conditions of the patient have also been identified. The sequence of dengue virus infections and association with certain genotypes are further factors of importance. We also discuss the control and prevention strategies. In conclusion, without urgent action for the prevention and control of dengue/DHF and its vector, the current situation will worsen and, more dramatical, there is a risk of the urbanization of yellow fever.

  11. Long-term cycles in old Novae

    International Nuclear Information System (INIS)

    Shara, M.M.; Potter, M.; Shara, D.J.

    1989-01-01

    Three of the oldest recovered novae were monitored with a CCD camera almost nightly for six weeks. The cyclic variability reported by Della Valle and Rosino (1987) for Nova Oph 1848 is confirmed. A similar variability is also suggested for Nova Cyg 1876, though this system exhibits more random flickering than Nova Oph. No secular variability is seen in Nova Sge 1783. 12 refs

  12. Dengue antibodies in blood donors Pesquisa de anticorpos antidengue em doadores de sangue

    Directory of Open Access Journals (Sweden)

    Rejane Cristina Ribas-Silva

    2012-01-01

    Full Text Available BACKGROUND: Dengue is an urban arbovirus whose etiologic agent is a virus of the genus Flavorius with four distinct antigen serotypes (DENV-1, DENV-2, DENV-3 and DENV-4 that is transmitted to humans through the bite of the mosquito Aedes aegypti. The Campo Mourão region in Brazil is endemic for dengue fever. OBTECTIVE: The aim of this study was to evaluate the presence of IgG and IgM antibodies specific to the four serotypes of dengue in donors of the blood donor service in the city of Campo Mourão. METHODS: Epidemiological records were evaluated and 4 mL of peripheral blood from 213 blood donors were collected in tubes without anticoagulant. Serum was then obtained and immunochromatographic tests were undertaken (Imuno-Rápido Dengue IgM/IgG TM. Individuals involved in the study answered a social and epidemiological questionnaire on data which included age, gender and diagnosis of dengue. RESULTS: Only three (1.4% of the 213 blood tests were positive for IgG anti-dengue antibodies. No donors with IgM antibody, which identifies acute infection, were identified. CONCLUSIONS: The results of the current analysis show that the introduction of quantitative or molecular serological methods to determine the presence of anti-dengue antibodies or the detection of the dengue virus in blood donors in endemic regions should be established so that the quality of blood transfusions is guaranteed.OBJETIVO: O objetivo desta pesquisa foi realizar uma triagem sorológica para detectar a presença de anticorpos IgG e IgM específicos para os quatro sorotipos da dengue em doadores de sangue atendidos pelo Hemonúcleo de Campo Mourão-PR. MÉTODOS: foram aplicadas fichas epidemiológicas e coletados 4 mL de sangue periférico em tubos sem anticoagulante de 213 doadores de sangue. Posteriormente, foi obtido o soro e realizado o teste imunocromatrográfico (Imuno - Rápido Dengue IgM/IgG. Os indivíduos envolvidos neste estudo responderam um questionário s

  13. Dengue and the risk of urban yellow fever reintroduction in São Paulo State, Brazil Dengue e risco da reintrodução da febre amarela urbana no Estado de São Paulo

    Directory of Open Access Journals (Sweden)

    Eduardo Massad

    2003-08-01

    Full Text Available OBJECTIVE: To propose a mathematical method for the estimation of the Basic Reproduction Number, R0, of urban yellow fever in a dengue-infested area. METHODS: The method is based on the assumption that, as the same vector (Aedes aegypti causes both infections, all the quantities related to the mosquito, estimated from the initial phase of dengue epidemic, could be applied to yellow fever dynamics. It is demonstrated that R0 for yellow fever is, on average, 43% lower than that for dengue. This difference is due to the longer dengue viremia and its shorter extrinsic incubation period. RESULTS: In this study the analysis was expanded to the epidemiological situation of dengue in São Paulo in the year 2001. The total number of dengue cases increased from 3,582 in 2000 to 51,348 in 2001. It was then calculated R0 for yellow fever for every city which have shown R0 of dengue greater than 1. It was also estimated the total number of unprotected people living in highly risky areas for urban yellow fever. CONCLUSIONS: Currently there is a great number of non-vaccinated people living in Aedes aegypti infested area in the state of São Paulo.OBJETIVO: Propor um modelo matemático para a estimativa da reprodutibilidade basal, R0, para a febre amarela urbana em uma área infestada pela dengue. MÉTODOS: O método utilizado considera que, como ambas as doenças são transmitidas pelo mesmo vetor (Aedes aegypti, poder-se-ia aplicar todos os parâmetros quantitativos relativos ao mosquito, estimados pela fase inicial da curva de crescimento de casos de dengue, à dinâmica da febre amarela. Demonstra-se que o R0 da febre amarela é em média 43% menor que o da dengue. Esta diferença deve-se à viremia mais prolongada da dengue, bem como ao menor período de incubação extrínseco daquele vírus no mosquito. RESULTADOS: Apresenta-se a aplicação desta análise matemática à situação epidemiológica da dengue no estado de São Paulo, para o ano de 2001

  14. Nova frequency conversion and focusing system

    International Nuclear Information System (INIS)

    Summers, M.A.; Seppala, L.G.; Williams, J.D.

    1985-01-01

    New developments in crystal array technology provided significant improvements in the mechanical design and optical performance of the Nova 2 omega/3 omega array hardware. The final Nova array configuration was tested on the Novette laser and on the first arm of Nova. Ten Nova 2 omega/3 omega crystal arrays were assembled and tested for crystal alignment and wave front distortion before installation on the Nova target chamber. Ten Nova focus lens positioners were assembled and tested last year. The positioning accuracy and repeatability of each assembly were evaluated before installation on the target chamber. A cylindrical focusing system was also developed for installation in the Nova lens positioner assembly. Finally, 10 completed frequency conversion and focusing systems were activated

  15. Ecg manifestations in dengue infection

    International Nuclear Information System (INIS)

    Tarique, S.; Murtaza, G.; Asif, S.; Qureshi, I.H.

    2013-01-01

    To determine the frequency of ECG changes in patients with dengue fever and dengue hemorrhagic fever. Place of study: Department of Medicine, Mayo Hospital Lahore Duration of study: September to November 201 Study design: Cross sectional analytical study Patient and methods: 116 patients with dengue infection were enrolled in the study. Their clinical presentation and examination was duly noted. Each patient had baseline and then regular monitoring of blood counts, metabolic profile and fluid status. Patients with Dengue Hemorrhagic fever underwent radiological examination in form of chest radiograph and ultrasound abdomen. ECG was carried out in all patients. Results: Out of 116 patients, 61(52.6%) suffered from Dengue Fever and 55(47.4%) had Dengue Hemorrhagic Fever. Overall 78 patients had normal ECG. Abnormal ECG findings like tachycardia, bradycardia, supraventricular tachycardia, left bundle branch block, ST depression, poor progression of R wave were noted. There was no significant relationship of ECG findings with the disease. Conclusion: ECG changes can occur in dengue infection with or without cardiac symptoms. Commonly noted findings were ST depression and bradycardia. (author)

  16. Dengue viruses in Brazil, 1986-2006 Virus del dengue en Brasil, 1986-2006

    Directory of Open Access Journals (Sweden)

    Rita Maria Ribeiro Nogueira

    2007-11-01

    Full Text Available A total of 4 243 049 dengue cases have been reported in Brazil between 1981 and 2006, including 5 817 cases of dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS and a total of 338 fatal cases. Although all Brazilian regions have been affected, the Northeast and Southeast regions have registered the highest number of notifications. DENV-1 and DENV-4 were isolated for the first time in the Amazon region of Brazil in 1981 and 1982. The disease became a nationwide public health problem following outbreaks of DENV-1 and DENV-2 in the state of Rio de Janeiro in 1986 and 1990, respectively. The introduction of DENV-3 in 2000, also in the state of Rio de Janeiro, led to a severe epidemic with 288 245 reported dengue cases, including 91 deaths. Virus strains that were typed during the 2002 epidemic show that DENV-3 has displaced other dengue virus serotypes and entered new areas, a finding that warrants closer evaluation. Unusual clinical symptoms, including central nervous system involvement, have been observed in dengue patients in at least three regions of the country.En Brasil se han notificado 4 243 049 casos de dengue entre 1981 y 2006, de ellos 5 817 casos de dengue hemorrágico/síndrome de choque por dengue (DH/SCD y un total de 338 casos mortales. A pesar de que la enfermedad ha afectado a todas las regiones brasileñas, el mayor número de casos se ha notificado en las regiones nororiental y suroriental. Los virus del dengue (DENV 1 y 4 se aislaron por primera vez en la región amazónica de Brasil en 1981 y 1982. La enfermedad se convirtió en un problema nacional de salud pública después de los brotes de DENV-1 y DENV-2 en el Estado de Río de Janeiro en 1986 y 1990, respectivamente. La introducción del DENV-3 en 2000, también en el Estado de Río de Janeiro, llevó a una grave epidemia con 288 245 casos notificados de dengue y 91 muertes. Las cepas del virus identificadas durante la epidemia de 2002 demostraron que el DENV-3 ha

  17. De mochila nas costas, reconstruindo as trilhas da revista Realidade e em busca de novas narrativas. Revista Campus Repórter-UnB

    Directory of Open Access Journals (Sweden)

    Dione Oliveira Moura

    2009-12-01

    Full Text Available O artigo descreve a experiência de uma revista laboratório da Faculdade de Comunicação da Universidade de Brasília, revista Campus Repórter, lançada no ano de 2007, mas, vai além e problematiza, a partir de experiências concretas, o espaço de ensino-aprendizagem em produção de reportagens como um espaço para construção de (novas formas narrativas para o jornalismo impresso, especialmente o jornalismo de revista. Também descreve o modo de produção colaborativa da revista, a qual envolve estudantes de jornalismo, publicidade e desenho industrial, com supervisão de professores editores da área de reportagem, fotojornalismo e planejamento gráfico.Conclui que a experiência colaborativa na produção de uma revista laboratório soma resultados e que a revista tem trilhado um caminho que aponta para novas formas narrativas mais atentas à polissemia, assim como a perspectivas inovadores de narrar fatos cotidianos a partir de uma perspectiva mais contextual, com inspiração na revista Realidade (1966 a 1976.

  18. Neurological Manifestations of Dengue Infection

    Directory of Open Access Journals (Sweden)

    Guo-Hong Li

    2017-10-01

    Full Text Available Dengue counts among the most commonly encountered arboviral diseases, representing the fastest spreading tropical illness in the world. It is prevalent in 128 countries, and each year >2.5 billion people are at risk of dengue virus infection worldwide. Neurological signs of dengue infection are increasingly reported. In this review, the main neurological complications of dengue virus infection, such as central nervous system (CNS, peripheral nervous system, and ophthalmic complications were discussed according to clinical features, treatment and possible pathogenesis. In addition, neurological complications in children were assessed due to their atypical clinical features. Finally, dengue infection and Japanese encephalitis were compared for pathogenesis and main clinical manifestations.

  19. Human Immune Response to Dengue Infections

    Science.gov (United States)

    1991-06-30

    had been immunized with yellow fever vaccine and later became infected with dengue 3 virus, responded best to dengue 3 antigen but also responded to...effective dengue virus subunit vaccines . We found evidence of marked T cell activation in patients with DHF. T cell activation in patients with DF was similar...Treatment and Control of Dengue Hemorrhagic Fever. World Health Organization, Geneva, Switzerland 7. Sabin AB (1952) Research on dengue during World

  20. TPM na TRECAR : uma nova abordagem à gestão da manutenção

    OpenAIRE

    Resende, António Pedro Ferreira Carreira

    2014-01-01

    A manutenção tem vindo a assumir um papel preponderante na atividade industrial, uma vez que é esta área departamental que possibilita à produção, um fluxo contínuo de atividade, atenuando os tempos de paragem dos equipamentos (downtime). A evolução histórica mostra este avanço e a importância da manutenção nas indústrias, apesar de atualmente se verificar uma redução nas despesas associadas a este setor, devido à crise económica global. O TPM surge como uma abordagem à gestão da manutenção, ...

  1. Uranium in Nova Scotia: a background summary for the uranium inquiry, Nova Scotia

    International Nuclear Information System (INIS)

    1982-01-01

    Since the mid 1970's Nova Scotia has experienced increased exploration for a number of commodities including uranium. The exploration activity for uranium has resulted in discovery of significant occurrences of the element. It became obvious to the Government of Nova Scotia that a segment of the population of the Province is concerned about the potential hazards associated with the exploration, mining and milling stages of the uranium industry. Public concern has resulted in the appointment of a Commissioner under the Public Inquiries Act of Nova Scotia to inquire and make recommendations to the Governor-in-Council on all aspects of exploration, development, mining, processing, storage, waste management and transportation of uranium in any form. The regulation of mineral exploration and mining activities is carried out by the Nova Scotia Department of Mines and Energy through the Mineral Resources Act of the Province of Nova Scotia. The regulation of the special radioactive aspects involved in the mining and processing of uranium ore is the responsibility of the federal Atomic Energy Control Board. The purposes of this report is to: outline the history of uranium exploration in Nova Scotia; summarize the results of geological surveys by provincial and federal government agencies, universities and exploration companies which document the natural levels of radioactivity in the Province; briefly outline the physical and chemical characteristics of uranium and thorium which make these elements unique and a potential environmental and health concern; outline chronologically the steps taken by the Nova Scotia Department of Mines and Energy to monitor and regulate uranium exploration activities; classify the types of uranium deposits known to occur in Nova Scotia and describe their main geological features; outline the role of the Nova Scotia Department of Mines and Energy in the regulation of mining activities in the Province. The report is written for the interested

  2. Evaluation of Internet-based dengue query data: Google Dengue Trends.

    Directory of Open Access Journals (Sweden)

    Rebecca Tave Gluskin

    2014-02-01

    Full Text Available Dengue is a common and growing problem worldwide, with an estimated 70-140 million cases per year. Traditional, healthcare-based, government-implemented dengue surveillance is resource intensive and slow. As global Internet use has increased, novel, Internet-based disease monitoring tools have emerged. Google Dengue Trends (GDT uses near real-time search query data to create an index of dengue incidence that is a linear proxy for traditional surveillance. Studies have shown that GDT correlates highly with dengue incidence in multiple countries on a large spatial scale. This study addresses the heterogeneity of GDT at smaller spatial scales, assessing its accuracy at the state-level in Mexico and identifying factors that are associated with its accuracy. We used Pearson correlation to estimate the association between GDT and traditional dengue surveillance data for Mexico at the national level and for 17 Mexican states. Nationally, GDT captured approximately 83% of the variability in reported cases over the 9 study years. The correlation between GDT and reported cases varied from state to state, capturing anywhere from 1% of the variability in Baja California to 88% in Chiapas, with higher accuracy in states with higher dengue average annual incidence. A model including annual average maximum temperature, precipitation, and their interaction accounted for 81% of the variability in GDT accuracy between states. This climate model was the best indicator of GDT accuracy, suggesting that GDT works best in areas with intense transmission, particularly where local climate is well suited for transmission. Internet accessibility (average ∼ 36% did not appear to affect GDT accuracy. While GDT seems to be a less robust indicator of local transmission in areas of low incidence and unfavorable climate, it may indicate cases among travelers in those areas. Identifying the strengths and limitations of novel surveillance is critical for these types of data to

  3. Reviewing dengue: still a neglected tropical disease?

    Science.gov (United States)

    Horstick, Olaf; Tozan, Yesim; Wilder-Smith, Annelies

    2015-04-01

    Dengue is currently listed as a "neglected tropical disease" (NTD). But is dengue still an NTD or not? Classifying dengue as an NTD may carry advantages, but is it justified? This review considers the criteria for the definition of an NTD, the current diverse lists of NTDs by different stakeholders, and the commonalities and differences of dengue with other NTDs. We also review the current research gaps and research activities and the adequacy of funding for dengue research and development (R&D) (2003-2013). NTD definitions have been developed to a higher precision since the early 2000s, with the following main features: NTDs are characterised as a) poverty related, b) endemic to the tropics and subtropics, c) lacking public health attention, d) having poor research funding and shortcomings in R&D, e) usually associated with high morbidity but low mortality, and f) often having no specific treatment available. Dengue meets most of these criteria, but not all. Although dengue predominantly affects resource-limited countries, it does not necessarily only target the poor and marginalised in those countries. Dengue increasingly attracts public health attention, and in some affected countries it is now a high profile disease. Research funding for dengue has increased exponentially in the past two decades, in particular in the area of dengue vaccine development. However, despite advances in dengue research, dengue epidemics are increasing in frequency and magnitude, and dengue is expanding to new areas. Specific treatment and a highly effective vaccine remain elusive. Major research gaps exist in the area of integrated surveillance and vector control. Hence, although dengue differs from many of the NTDs, it still meets important criteria commonly used for NTDs. The current need for increased R&D spending, shared by dengue and other NTDs, is perhaps the key reason why dengue should continue to be considered an NTD.

  4. Reviewing dengue: still a neglected tropical disease?

    Directory of Open Access Journals (Sweden)

    Olaf Horstick

    2015-04-01

    Full Text Available Dengue is currently listed as a "neglected tropical disease" (NTD. But is dengue still an NTD or not? Classifying dengue as an NTD may carry advantages, but is it justified? This review considers the criteria for the definition of an NTD, the current diverse lists of NTDs by different stakeholders, and the commonalities and differences of dengue with other NTDs. We also review the current research gaps and research activities and the adequacy of funding for dengue research and development (R&D (2003-2013. NTD definitions have been developed to a higher precision since the early 2000s, with the following main features: NTDs are characterised as a poverty related, b endemic to the tropics and subtropics, c lacking public health attention, d having poor research funding and shortcomings in R&D, e usually associated with high morbidity but low mortality, and f often having no specific treatment available. Dengue meets most of these criteria, but not all. Although dengue predominantly affects resource-limited countries, it does not necessarily only target the poor and marginalised in those countries. Dengue increasingly attracts public health attention, and in some affected countries it is now a high profile disease. Research funding for dengue has increased exponentially in the past two decades, in particular in the area of dengue vaccine development. However, despite advances in dengue research, dengue epidemics are increasing in frequency and magnitude, and dengue is expanding to new areas. Specific treatment and a highly effective vaccine remain elusive. Major research gaps exist in the area of integrated surveillance and vector control. Hence, although dengue differs from many of the NTDs, it still meets important criteria commonly used for NTDs. The current need for increased R&D spending, shared by dengue and other NTDs, is perhaps the key reason why dengue should continue to be considered an NTD.

  5. Dengue fever outbreak: a clinical management experience

    International Nuclear Information System (INIS)

    Ahmed, S.; Illyas, M.

    2008-01-01

    To determine the frequency of dengue as a cause of fever and compare the clinical and haematological characteristics of Dengue-probable and Dengue-proven cases. All patients with age above 14 years, who were either hospitalized or treated in medical outdoor clinic due to acute febrile illness, were evaluated for clinical features of Dengue Fever (DF), Dengue haemorrhagic fever (DHF) and Dengue Shock Syndrome (DSS). Patients showing typical clinical features and haematological findings suggestive of Dengue fever (As per WHO criteria) were evaluated in detail for comparison of probable and confirmed cases of Dengue fever. All other cases of acute febrile illness, not showing clinical features or haematological abnormalities of Dengue fever, were excluded. The clinical and laboratory features were recorded on SPSS 11.0 programme and graded where required, for descriptive and statistical analysis. Out of 5200 patients with febrile illness, 107 (2%) presented with typical features of DF, 40/107 (37%) were Dengue-proven while 67/107 (63%) were Dengue-probable. Out of Dengue-proven cases, 38 were of DF and 2 were of DHF. Day 1 temperature ranged from 99-105 degreeC (mean 101 degree C). Chills and rigors were noticed in 86 (80%), myalgia in 67%, headache in 54%, pharyngitis in 35%, rash in 28%, and bleeding manifestations in 2% cases. Hepatomegaly in 1(0.5%), lymphadenopathy in 1 (0.5%) and splenomegaly in 12 (11.2%) cases. Leucopoenia (count 40 U/L in 57% cases. Frequency of clinically suspected dengue virus infection was 107 (2%), while confirmed dengue fever cases were 40 (0.8%) out of 5200 fever cases. Fever with chills and rigors, body aches, headache, myalgia, rash, haemorrhagic manifestations, platelet count, total leukocyte count, and ALT, are parameters to screen the cases of suspected dengue virus infection, the diagnosis cannot be confirmed unless supported by molecular studies or dengue specific IgM. (author)

  6. Profile of dengue hepatitis in children from India and its correlation with WHO dengue case classifiation

    Directory of Open Access Journals (Sweden)

    Neelam Mohan

    2017-06-01

    Full Text Available Objective: To study the profile of liver involvement in children with dengue fever and to compare the severity of liver involvement with World Health Organization case definition. Methods: A prospective study was carried out from October 2013 to December 2014. Serologically confirmed dengue patients were grouped into three categories according to the World Health Organization classification. Groups 1 and 2 were dengue fever without and with warning signs, respectively; Group 3 was severe dengue. Biochemical and clinical profile of hepatic involvement was studied. Results: A total of 162 children with dengue fever (M:F = 2.37 were included in the study. Median (inter quartile range age was 12 years (IQR: 0.5–18 years. Hepatitis was observed in 151 (93.2% patients. Analysis revealed that out of all liver function test parameters, total bilirubin was found to be a significant predictor of dengue category two and three and albumin and ALT levels were significant predictors for category three. Eight cases presented with ALF. Their median AST was 4 817 (range 61–26 957; median ALT was 2 386 (range 39–11 100; median INR was 2.57 (range 1.6–4.2 and their median serum bilirubin was 2.95 (range 0.6–9.0. Conclusions: Some degree of hepatitis is very common in dengue infection with rise in AST being more than ALT irrespective of the severity of dengue. Severity of hepatitis correlates well with the severity of dengue and can help in triaging of dengue patients. Of all liver function parameters, total bilirubin levels correlate best with severity of dengue infection.

  7. Climate and dengue transmission: evidence and implications.

    Science.gov (United States)

    Morin, Cory W; Comrie, Andrew C; Ernst, Kacey

    2013-01-01

    Climate influences dengue ecology by affecting vector dynamics, agent development, and mosquito/human interactions. Although these relationships are known, the impact climate change will have on transmission is unclear. Climate-driven statistical and process-based models are being used to refine our knowledge of these relationships and predict the effects of projected climate change on dengue fever occurrence, but results have been inconsistent. We sought to identify major climatic influences on dengue virus ecology and to evaluate the ability of climate-based dengue models to describe associations between climate and dengue, simulate outbreaks, and project the impacts of climate change. We reviewed the evidence for direct and indirect relationships between climate and dengue generated from laboratory studies, field studies, and statistical analyses of associations between vectors, dengue fever incidence, and climate conditions. We assessed the potential contribution of climate-driven, process-based dengue models and provide suggestions to improve their performance. Relationships between climate variables and factors that influence dengue transmission are complex. A climate variable may increase dengue transmission potential through one aspect of the system while simultaneously decreasing transmission potential through another. This complexity may at least partly explain inconsistencies in statistical associations between dengue and climate. Process-based models can account for the complex dynamics but often omit important aspects of dengue ecology, notably virus development and host-species interactions. Synthesizing and applying current knowledge of climatic effects on all aspects of dengue virus ecology will help direct future research and enable better projections of climate change effects on dengue incidence.

  8. Evolução histórica dos programas de prevenção e controle da dengue no Brasil The historical evolution of dengue prevention and control programs in Brazil

    Directory of Open Access Journals (Sweden)

    Beatriz Jansen Ferreira

    2009-06-01

    Full Text Available Avaliou-se a dengue mundial e nacionalmente, através de uma análise epidemiológica quanto à distribuição e formas. Avaliou-se o Programa Nacional de Controle à Dengue (PNCD quanto a sua implantação através do estudo do Diagdengue. Foi feita uma análise fatorial através de um conjunto de indicadores contributivos para a variabilidade. Somou-se os escores dos indicadores e a classificação dos municípios prioritários para o PNCD, para a construção de um índice, apresentando-o por estado e por trimestre, com intervalos distribuídos num intervalo de 0 a 9. A implantação do PNCD se dá de forma irregular, prevalecendo municípios com implantação ruim na região Norte e Nordeste. Na segunda análise, agregou-se a variáveis socioeconômicas dos municípios selecionados. Para os testes de associação, agrupou-se em duas classes: "ruim" e "bom/muito bom". Considerou-se a associação entre o índice de infestação predial informados no banco de dados do FAD e o índice construído. Foram usados para a verificação de associação testes de análise variância, teste de tendência e estimativa de razões de chance. Observou-se que municípios com baixo analfabetismo, alta coleta de lixo, alta proporção de instalações sanitárias estão correlacionados com uma boa classificação do município em relação ao Diagdengue.An epidemiological analysis of the forms and distribution of Dengue fever in Brazil and worldwide was carried out. The National Program of Dengue Control (NPDC was evaluated based on the data available at "Diagdengue" an official computerized information system allowing to follow-up the implantation and impact of the Program. A factorial analysis was performed by means of a set of indicators contributing to variability. The indicator scores were added and the cities demanding for prior attention of the NPCD were classified for the construction of an index, which is presented three-monthly for every state, with

  9. Overview of current situation of dengue and dengue vector control

    Science.gov (United States)

    Dengue is the most important arbovirus of humans in the world. It is caused by one of four closely related virus serotypes whose primary vector is Aedes aegypti and secondarily by Ae. albopictus. A global dengue pandemic began in Southeast Asia after World War II and has intensified during the las...

  10. The NOvA Technical Design Report

    International Nuclear Information System (INIS)

    Ayres, D.S.; Drake, G.R.; Goodman, M.C.; Grudzinski, J.J.; Guarino, V.J.; Talaga, R.L.; Zhao, A.; Stamoulis, P.; Stiliaris, E.; Tzanakos, G.; Zois, M.

    2007-01-01

    Technical Design Report (TDR) describes the preliminary design of the NOvA accelerator upgrades, NOvA detectors, detector halls and detector sites. Compared to the March 2006 and November 2006 NOvA Conceptual Design Reports (CDR), critical value engineering studies have been completed and the alternatives still active in the CDR have been narrowed to achieve a preliminary technical design ready for a Critical Decision 2 review. Many aspects of NOvA described this TDR are complete to a level far beyond a preliminary design. In particular, the access road to the NOvA Far Detector site in Minnesota has an advanced technical design at a level appropriate for a Critical Decision 3a review. Several components of the accelerator upgrade and new neutrino detectors also have advanced technical designs appropriate for a Critical Decision 3a review. Chapter 1 is an Executive Summary with a short description of the NOvA project. Chapter 2 describes how the Fermilab NuMI beam will provide a narrow band beam of neutrinos for NOvA. Chapter 3 gives an updated overview of the scientific basis for the NOvA experiment, focusing on the primary goal to extend the search for ν μ → ν e oscillations and measure the sin 2 (2θ 13 ) parameter. This parameter has not been measured in any previous experiment and NOvA would extend the search by about an order of magnitude beyond the current limit. A secondary goal is to measure the dominant mode oscillation parameters, sin 2 (2θ 23 ) and Δm 32 2 to a more precise level than previous experiments. Additional physics goals for NOvA are also discussed. Chapter 4 describes the Scientific Design Criteria which the Fermilab accelerator complex, NOvA detectors and NOvA detector sites must satisfy to meet the physics goals discussed in Chapter 3. Chapter 5 is an overview of the NOvA project. The changes in the design relative to the NOvA CDR are discussed. Chapter 6 summarizes the NOvA design performance relative to the Design Criteria set out

  11. Climate change in Nova Scotia : a background paper to guide Nova Scotia's climate change action plan

    International Nuclear Information System (INIS)

    2007-10-01

    Climate change causes changes in the temperature of the earth, the level of the sea, and the frequency of extreme weather conditions. The province of Nova Scotia recently released an act related to environmental goals and sustainable prosperity. Addressing climate change is a key element in achieving Nova Scotia's sustainable prosperity goals outlined in the act. The Nova Scotia Department of Energy is working towards developing both policy and action, to help meet its target of a 10 per cent reduction in greenhouse gases from 1990 levels by the year 2020. Two major plans are underway, notably a climate change action plan and a renewed energy strategy. This report provided background information on Nova Scotia's climate change action plan. It discussed climate change issues affecting Nova Scotia, air pollutants, energy sources in Nova Scotia, energy consumers in the province, and Nova Scotia's approach to climate change. The report also discussed actions underway and funding sources. It was concluded that in order for the climate change action plan to be successful, Nova Scotians must use energy more efficiently; use renewable energy; use cleaner energy; and plan for change. 13 refs., 2 tabs., 6 figs., 4 appendices

  12. Novas Modulações do Controle Organizacional: um Estudo de Caso

    Directory of Open Access Journals (Sweden)

    Cláudia Maria Perrone

    Full Text Available Resumo O poder nas organizações não se manifesta apenas por vias coercitivas na atualidade. Ele atua por meio de dispositivos de poder, nos quais são incluídos os métodos disciplinares, que operam diretamente na subjetividade do sujeito. Esses mecanismos tornam os trabalhadores reconhecíveis, identificáveis e comparáveis entre si. Este estudo objetivou explicitar parte dos resultados de uma pesquisa sobre controle organizacional e subjetividade no contemporâneo. A pesquisa referida investigou a lógica pós-disciplinar presente nos mecanismos de controle organizacional por meio da problematização do nexo entre tecnologia e subjetivação. Os resultados apresentados neste trabalho são relativos a uma parte da amostra total, composta de trinta sujeitos. Foi escolhido o caso de uma mulher, funcionária de uma instituição financeira transnacional, configurando este artigo como um estudo de caso. Os resultados do estudo de caso apontaram que a lógica vigente da organização do trabalho obriga que o trabalhador assuma para si as flutuações da demanda, bem como a responsabilidade dos resultados. Dessa forma, há indicativos que as novas formas de organização do trabalho possibilitam a autorresponsabilização do sujeito.

  13. Impact of Dengue Vaccination on Serological Diagnosis: Insights From Phase III Dengue Vaccine Efficacy Trials.

    Science.gov (United States)

    Plennevaux, Eric; Moureau, Annick; Arredondo-García, José L; Villar, Luis; Pitisuttithum, Punnee; Tran, Ngoc H; Bonaparte, Matthew; Chansinghakul, Danaya; Coronel, Diana L; L'Azou, Maïna; Ochiai, R Leon; Toh, Myew-Ling; Noriega, Fernando; Bouckenooghe, Alain

    2018-04-03

    We previously reported that vaccination with the tetravalent dengue vaccine (CYD-TDV; Dengvaxia) may bias the diagnosis of dengue based on immunoglobulin M (IgM) and immunoglobulin G (IgG) assessments. We undertook a post hoc pooled analysis of febrile episodes that occurred during the active surveillance phase (the 25 months after the first study injection) of 2 pivotal phase III, placebo-controlled CYD-TDV efficacy studies that involved ≥31000 children aged 2-16 years across 10 countries in Asia and Latin America. Virologically confirmed dengue (VCD) episode was defined with a positive test for dengue nonstructural protein 1 antigen or dengue polymerase chain reaction. Probable dengue episode was serologically defined as (1) IgM-positive acute- or convalescent-phase sample, or (2) IgG-positive acute-phase sample and ≥4-fold IgG increase between acute- and convalescent-phase samples. There were 1284 VCD episodes (575 and 709 in the CYD-TDV and placebo groups, respectively) and 17673 other febrile episodes (11668 and 6005, respectively). Compared with VCD, the sensitivity and specificity of probable dengue definition were 93.1% and 77.2%, respectively. Overall positive and negative predictive values were 22.9% and 99.5%, respectively, reflecting the much lower probability of correctly confirming probable dengue in a population including a vaccinated cohort. Vaccination-induced bias toward false-positive diagnosis was more pronounced among individuals seronegative at baseline. Caution will be required when interpreting IgM and IgG data obtained during routine surveillance in those vaccinated with CYD-TDV. There is an urgent need for new practical, dengue-specific diagnostic algorithms now that CYD-TDV is approved in a number of dengue-endemic countries. NCT01373281 and NCT01374516.

  14. Dengue death with evidence of hemophagocytic syndrome and dengue virus infection in the bone marrow.

    Science.gov (United States)

    Ab-Rahman, Hasliana Azrah; Wong, Pooi-Fong; Rahim, Hafiz; Abd-Jamil, Juraina; Tan, Kim-Kee; Sulaiman, Syuhaida; Lum, Chai-See; Syed-Omar, Syarifah-Faridah; AbuBakar, Sazaly

    2015-01-01

    HPS is a potentially life-threatening histiocytic disorder that has been described in various viral infections including dengue. Its involvement in severe and fatal dengue is probably more common but is presently under recognized. A 38-year-old female was admitted after 5 days of fever. She was deeply jaundiced, leukopenic and thrombocytopenic. Marked elevation of transaminases, hyperbilirubinemia and hypoalbuminemia were observed. She had deranged INR values and prolonged aPTT accompanied with hypofibrinogenemia. She also had splenomegaly. She was positive for dengue IgM. Five days later she became polyuric and CT brain image showed gross generalized cerebral edema. Her conditions deteriorated by day 9, became confused with GCS of 9/15. Her BMAT showed minimal histiocytes. Her serum ferritin level peaked at 13,670.00 µg/mL and her sCD163 and sCD25 values were markedly elevated at 4750.00 ng/mL and 4191.00 pg/mL, respectively. She succumbed to the disease on day 10 and examination of her tissues showed the presence of dengue virus genome in the bone marrow. It is described here, a case of fatal dengue with clinical features of HPS. Though BMAT results did not show the presence of macrophage hemophagocytosis, other laboratory features were consistent with HPS especially marked elevation of ferritin, sCD163 and sCD25. Detection of dengue virus in the patient's bone marrow, fifteen days after the onset of fever was also consistent with the suggestion that the HPS is associated with dengue virus infection. The findings highlight HPS as a possible complication leading to severe dengue and revealed persistent dengue virus infection of the bone marrow. Detection of HPS markers; ferritin, sCD163 and sCD25, therefore, should be considered for early recognition of HPS-associated dengue.

  15. Lo que usted debe saber acerca del dengue

    OpenAIRE

    Vélez, Juan David; Fundación Valle de Lili; Salazar, Juan Carlos; Rosso Suárez, Fernando

    1998-01-01

    Epidemiología del dengue/Transmisión/Presentación clínica/Síntomas en niños/Diagnostico de laboratorio/Dengue clásico/Dengue hemorrágico/Dengue hemorrágico con choque/ ¿Qué es dengue hemorrágico?/ ¿Cuál es la diferencia entre dengue hemorrágico y dengue clásico?/ ¿Qué son las plaquetas?/ ¿Qué puedo hacer para prevenir el dengue?/ ¿Cuándo debo consultar?/ ¿Cuándo se debe hacer un hemograma?/ ¿Cuándo se debe hospitalizar un paciente con dengue?

  16. Neurological manifestations of dengue viral infection

    Directory of Open Access Journals (Sweden)

    Carod-Artal FJ

    2014-10-01

    Full Text Available Francisco Javier Carod-Artal1,21Neurology Department, Raigmore hospital, Inverness, UK; 2Universitat Internacional de Catalunya (UIC, Barcelona, Spain Abstract: Dengue is the most common mosquito-borne viral infection worldwide. There is increased evidence for dengue virus neurotropism, and neurological manifestations could make part of the clinical picture of dengue virus infection in at least 0.5%–7.4% of symptomatic cases. Neurological complications have been classified into dengue virus encephalopathy, dengue virus encephalitis, immune-mediated syndromes (acute disseminated encephalomyelitis, myelitis, Guillain–Barré syndrome, neuritis brachialis, acute cerebellitis, and others, neuromuscular complications (hypokalemic paralysis, transient benign muscle dysfunction and myositis, and dengue-associated stroke. Common neuro-ophthalmic complications are maculopathy and retinal vasculopathy. Pathogenic mechanisms include systemic complications and metabolic disturbances resulting in encephalopathy, direct effect of the virus provoking encephalitis, and postinfectious immune mechanisms causing immune-mediated syndromes. Dengue viruses should be considered as a cause of neurological disorders in endemic regions. Standardized case definitions for specific neurological complications are still needed. Keywords: encephalitis, encephalopathy, dengue fever, neurological complications

  17. As novas tecnologias legais na produção da vida familiar: antropologia, direito e subjetividades = New legal technologies in family life production: anthopology, law and subjectivation

    Directory of Open Access Journals (Sweden)

    Fonseca, Cláudia

    2011-01-01

    Full Text Available Nesse artigo, exploramos a possível parceria entre a antropologia do direito e a teoria da biopolítica. Formulamos nossa contribuição a partir de uma pesquisa sobre os usos da tecnologia de DNA em investigações de paternidade realizada em diferentes instâncias do sistema judiciário de Rio Grande do Sul. Aproveitamos observações etnográficas nesses espaços institucionais para entender como determinadas situações produzem (reforçando ou modificando sentimentos associados à família. Depois de apresentar uma cena etnográfica inicial em que objetivamos dar cor e vida aos sujeitos que povoam os tribunais, seguimos o roteiro traçado por Rabinow e Rose (2006 para entender a cadeia de influências entre uma nova forma de conhecimento, rearranjos na hierarquia de poder, e novos “modos de subjetivação”. Em outras palavras, propomos mostrar que o sistema legal faz mais do que “solucionar conflitos”. Cria tensões, redefine relações e molda novas subjetividades

  18. Comparison of real-time SYBR green dengue assay with real-time taqman RT-PCR dengue assay and the conventional nested PCR for diagnosis of primary and secondary dengue infection

    Science.gov (United States)

    Paudel, Damodar; Jarman, Richard; Limkittikul, Kriengsak; Klungthong, Chonticha; Chamnanchanunt, Supat; Nisalak, Ananda; Gibbons, Robert; Chokejindachai, Watcharee

    2011-01-01

    Background: Dengue fever and dengue hemorrhagic fever are caused by dengue virus. Dengue infection remains a burning problem of many countries. To diagnose acute dengue in the early phase we improve the low cost, rapid SYBR green real time assay and compared the sensitivity and specificity with real time Taqman® assay and conventional nested PCR assay. Aims: To develop low cost, rapid and reliable real time SYBR green diagnostic dengue assay and compare with Taqman real-time assay and conventional nested PCR (modified Lanciotti). Materials and Methods: Eight cultured virus strains were diluted in tenth dilution down to undetectable level by the PCR to optimize the primer, temperature (annealing, and extension and to detect the limit of detection of the assay. Hundred and ninety three ELISA and PCR proved dengue clinical samples were tested with real time SYBR® Green assay, real time Taqman® assay to compare the sensitivity and specificity. Results: Sensitivity and specificity of real time SYBR® green dengue assay (84% and 66%, respectively) was almost comparable to those (81% and 74%) of Taqman real time PCR dengue assay. Real time SYBR® green RT-PCR was equally sensitive in primary and secondary infection while real time Taqman was less sensitive in the secondary infection. Sensitivity of real time Taqman on DENV3 (87%) was equal to SYBR green real time PCR dengue assay. Conclusion: We developed low cost rapid diagnostic SYBR green dengue assay. Further study is needed to make duplex primer assay for the serotyping of dengue virus. PMID:22363089

  19. Dengue fever outbreak: a clinical management experience.

    Science.gov (United States)

    Ahmed, Shahid; Ali, Nadir; Ashraf, Shahzad; Ilyas, Mohammad; Tariq, Waheed-Uz-Zaman; Chotani, Rashid A

    2008-01-01

    To determine the frequency of dengue as a cause of fever and compare the clinical and haematological characteristics of Dengue-probable and Dengue-proven cases. An observational study. The Combined Military Hospital, Malir Cantt., Karachi, from August 2005 to December 2006. All patients with age above 14 years, who were either hospitalized or treated in medical outdoor clinic due to acute febrile illness, were evaluated for clinical features of Dengue Fever (DF), Dengue haemorrhagic fever (DHF) and Dengue Shock Syndrome (DSS). Patients showing typical clinical features and haematological findings suggestive of Dengue fever (As per WHO criteria) were evaluated in detail for comparison of probable and confirmed cases of Dengue fever. All other cases of acute febrile illness, not showing clinical features or haematological abnormalities of Dengue fever, were excluded. The clinical and laboratory features were recorded on SPSS 11.0 programme and graded where required, for descriptive and statistical analysis. Out of 5200 patients with febrile illness, 107(2%) presented with typical features of DF, 40/107(37%) were Dengue-proven while 67/107(63%) were Dengue-probable. Out of Dengue-proven cases, 38 were of DF and 2 were of DHF. Day 1 temperature ranged from 99-1050C (mean 1010C). Chills and rigors were noticed in 86 (80%), myalgia in 67%, headache in 54%, pharyngitis in 35%, rash in 28%, and bleeding manifestations in 2% cases. Hepatomegaly in 1(0.5%), lymphadenopathy in 1(0.5%) and splenomegaly in 12 (11.2%) cases. Leucopoenia (count40 U/L in 57% cases. Frequency of clinically suspected dengue virus infection was 107 (2%), while confirmed dengue fever cases were 40 (0.8%) out of 5200 fever cases. Fever with chills and rigors, body aches, headache, myalgia, rash, haemorrhagic manifestations, platelet count, total leukocyte count, and ALT, are parameters to screen the cases of suspected dengue virus infection; the diagnosis cannot be confirmed unless supported by

  20. Economic Cost of Dengue in Puerto Rico

    Science.gov (United States)

    Halasa, Yara A.; Shepard, Donald S.; Zeng, Wu

    2012-01-01

    Dengue, endemic in Puerto Rico, reached a record high in 2010. To inform policy makers, we derived annual economic cost. We assessed direct and indirect costs of hospitalized and ambulatory dengue illness in 2010 dollars through surveillance data and interviews with 100 laboratory-confirmed dengue patients treated in 2008–2010. We corrected for underreporting by using setting-specific expansion factors. Work absenteeism because of a dengue episode exceeded the absenteeism for an episode of influenza or acute otitis media. From 2002 to 2010, the aggregate annual cost of dengue illness averaged $38.7 million, of which 70% was for adults (age 15+ years). Hospitalized patients accounted for 63% of the cost of dengue illness, and fatal cases represented an additional 17%. Households funded 48% of dengue illness cost, the government funded 24%, insurance funded 22%, and employers funded 7%. Including dengue surveillance and vector control activities, the overall annual cost of dengue was $46.45 million ($12.47 per capita). PMID:22556069

  1. Cells in Dengue Virus Infection In Vivo

    Directory of Open Access Journals (Sweden)

    Sansanee Noisakran

    2010-01-01

    Full Text Available Dengue has been recognized as one of the most important vector-borne emerging infectious diseases globally. Though dengue normally causes a self-limiting infection, some patients may develop a life-threatening illness, dengue hemorrhagic fever (DHF/dengue shock syndrome (DSS. The reason why DHF/DSS occurs in certain individuals is unclear. Studies in the endemic regions suggest that the preexisting antibodies are a risk factor for DHF/DSS. Viremia and thrombocytopenia are the key clinical features of dengue virus infection in patients. The amounts of virus circulating in patients are highly correlated with severe dengue disease, DHF/DSS. Also, the disturbance, mainly a transient depression, of hematological cells is a critical clinical finding in acute dengue patients. However, the cells responsible for the dengue viremia are unresolved in spite of the intensive efforts been made. Dengue virus appears to replicate and proliferate in many adapted cell lines, but these in vitro properties are extremely difficult to be reproduced in primary cells or in vivo. This paper summarizes reports on the permissive cells in vitro and in vivo and suggests a hematological cell lineage for dengue virus infection in vivo, with the hope that a new focus will shed light on further understanding of the complexities of dengue disease.

  2. Os efeitos maternos, fetais e infantis decorrentes da infecção por dengue durante a gestação em Rio Branco, Acre, Brasil, 2007-2012

    Directory of Open Access Journals (Sweden)

    Helena Albuquerque Catão Feitoza

    Full Text Available Os efeitos da infecção por dengue na gestação são desconhecidos em Rio Branco, Acre, Brasil. O objetivo deste trabalho é determinar os riscos de complicações maternas, fetais e infantis decorrentes da infecção por dengue durante a gestação. Estudo de coorte de gestantes expostas e não expostas ao vírus do dengue no período 2007-2012. Foram estimadas incidências e razões de risco de complicações maternas, fetais e infantis. Na coorte exposta houve 3 óbitos fetais e 5 neonatais. Dois óbitos maternos foram identificados na coorte exposta, desfecho ausente no grupo não exposto (p = 0,040. A coorte exposta apresentou uma razão de riscos - RR = 3,4 (IC95%: 1,02-11,23 para óbito neonatal. Em relação ao desfecho óbito neonatal precoce, a razão de riscos observada foi de 6,8 (IC95%: 1,61-28,75. Dez óbitos infantis ocorreram nos filhos de gestantes expostas e 7 nos de não expostas (RR = 6,0; IC95%: 2,24-15,87. As mulheres infectadas com o vírus do dengue na gestação apresentaram uma razão de riscos maior em relação à ocorrência de óbitos maternos, neonatais e infantis.

  3. The NOvA Technical Design Report

    Energy Technology Data Exchange (ETDEWEB)

    Ayres, D.S.; Drake, G.R.; Goodman, M.C.; Grudzinski, J.J.; Guarino, V.J.; Talaga, R.L.; Zhao, A.; /Argonne; Stamoulis, P.; Stiliaris, E.; Tzanakos, G.; Zois, M.; /Athens U. /Caltech /UCLA /Fermilab /College de France /Harvard U. /Indiana U. /Lebedev Inst. /Michigan State U. /Minnesota U., Duluth /Minnesota U.

    2007-10-08

    Technical Design Report (TDR) describes the preliminary design of the NOvA accelerator upgrades, NOvA detectors, detector halls and detector sites. Compared to the March 2006 and November 2006 NOvA Conceptual Design Reports (CDR), critical value engineering studies have been completed and the alternatives still active in the CDR have been narrowed to achieve a preliminary technical design ready for a Critical Decision 2 review. Many aspects of NOvA described this TDR are complete to a level far beyond a preliminary design. In particular, the access road to the NOvA Far Detector site in Minnesota has an advanced technical design at a level appropriate for a Critical Decision 3a review. Several components of the accelerator upgrade and new neutrino detectors also have advanced technical designs appropriate for a Critical Decision 3a review. Chapter 1 is an Executive Summary with a short description of the NOvA project. Chapter 2 describes how the Fermilab NuMI beam will provide a narrow band beam of neutrinos for NOvA. Chapter 3 gives an updated overview of the scientific basis for the NOvA experiment, focusing on the primary goal to extend the search for {nu}{sub {mu}} {yields} {nu}{sub e} oscillations and measure the sin{sup 2}(2{theta}{sub 13}) parameter. This parameter has not been measured in any previous experiment and NOvA would extend the search by about an order of magnitude beyond the current limit. A secondary goal is to measure the dominant mode oscillation parameters, sin{sup 2}(2{theta}{sub 23}) and {Delta}m{sub 32}{sup 2} to a more precise level than previous experiments. Additional physics goals for NOvA are also discussed. Chapter 4 describes the Scientific Design Criteria which the Fermilab accelerator complex, NOvA detectors and NOvA detector sites must satisfy to meet the physics goals discussed in Chapter 3. Chapter 5 is an overview of the NOvA project. The changes in the design relative to the NOvA CDR are discussed. Chapter 6 summarizes the NOvA

  4. Dengue antibodies in blood donors.

    Science.gov (United States)

    Ribas-Silva, Rejane Cristina; Eid, Andressa Ahmad

    2012-01-01

    Dengue is an urban arbovirus whose etiologic agent is a virus of the genus Flavorius with four distinct antigen serotypes (DENV-1, DENV-2, DENV-3 and DENV-4) that is transmitted to humans through the bite of the mosquito Aedes aegypti. The Campo Mourão region in Brazil is endemic for dengue fever. OBTECTIVE: The aim of this study was to evaluate the presence of IgG and IgM antibodies specific to the four serotypes of dengue in donors of the blood donor service in the city of Campo Mourão. Epidemiological records were evaluated and 4 mL of peripheral blood from 213 blood donors were collected in tubes without anticoagulant. Serum was then obtained and immunochromatographic tests were undertaken (Imuno-Rápido Dengue IgM/IgG(TM)). Individuals involved in the study answered a social and epidemiological questionnaire on data which included age, gender and diagnosis of dengue. Only three (1.4%) of the 213 blood tests were positive for IgG anti-dengue antibodies. No donors with IgM antibody, which identifies acute infection, were identified. The results of the current analysis show that the introduction of quantitative or molecular serological methods to determine the presence of anti-dengue antibodies or the detection of the dengue virus in blood donors in endemic regions should be established so that the quality of blood transfusions is guaranteed.

  5. Nova laser assurance-management system

    International Nuclear Information System (INIS)

    Levy, A.J.

    1983-01-01

    In a well managed project, Quality Assurance is an integral part of the management activities performed on a daily basis. Management assures successful performance within budget and on schedule by using all the good business, scientific, engineering, quality assurance, and safety practices available. Quality assurance and safety practices employed on Nova are put in perspective by integrating them into the overall function of good project management. The Nova assurance management system was developed using the quality assurance (QA) approach first implemented at LLNL in early 1978. The LLNL QA program is described as an introduction to the Nova assurance management system. The Nova system is described pictorially through the Nova configuration, subsystems and major components, interjecting the QA techniques which are being pragmatically used to assure the successful completion of the project

  6. Globalização, desemprego e (nova pobreza: Estudo sobre impactes nas sociedades portuguesa e brasileira

    Directory of Open Access Journals (Sweden)

    Cristina Albuquerque

    2012-11-01

    Full Text Available O presente artigo constitui‑se como um contributo para uma reflexão sobre possíveis conexões entre os processos de globalização económica, as mudanças no mercado de trabalho e os novos perfis da pobreza. O debate, enquadrado em dois contextos económicos distintos, o português (com ritmos de crescimento lentos e deficitários, com uma grave crise social e dificuldades de afirmação económica e política no contexto europeu e mundial e o brasileiro (com uma economia emergente e dinâmica, com fortes taxas de crescimento e uma tendência de redução nos índices de miséria e de pobreza, permite‑nos posicionar alguns dos impactes, económicos e sociais, decorrentes das pressões globais para a competitividade económica e potenciadores da emergência de novas formas de pobreza e de precarização social e laboral nas duas sociedades.

  7. Dengue: a new challenge for neurology

    Directory of Open Access Journals (Sweden)

    Marzia Puccioni-Sohler

    2012-11-01

    Full Text Available Dengue infection is a leading cause of illness and death in tropical and subtropical regions of the world. Forty percent of the world’s population currently lives in these areas. The clinical picture resulting from dengue infection can range from relatively minor to catastrophic hemorrhagic fever. Recently, reports have increased of neurological manifestations. Neuropathogenesis seems to be related to direct nervous system viral invasion, autoimmune reaction, metabolic and hemorrhagic disturbance. Neurological manifestations include encephalitis, encephalopathy, meningitis, Guillain-Barré syndrome, myelitis, acute disseminated encephalomyelitis, polyneuropathy, mononeuropathy, and cerebromeningeal hemorrhage. The development of neurological symptoms in patients with positive Immunoglobulin M (IgM dengue serology suggests a means of diagnosing the neurological complications associated with dengue. Viral antigens, specific IgM antibodies, and the intrathecal synthesis of dengue antibodies have been successfully detected in cerebrospinal fluid. However, despite diagnostic advancements, the treatment of neurological dengue is problematic. The launch of a dengue vaccine is expected to be beneficial.

  8. Prophylactic platelets in dengue

    DEFF Research Database (Denmark)

    Whitehorn, James; Rodriguez Roche, Rosmari; Guzman, Maria G

    2012-01-01

    Dengue is the most important arboviral infection of humans. Thrombocytopenia is frequently observed in the course of infection and haemorrhage may occur in severe disease. The degree of thrombocytopenia correlates with the severity of infection, and may contribute to the risk of haemorrhage...... of platelets in dengue. Respondents were all physicians involved with the treatment of patients with dengue. Respondents were asked that their answers reflected what they would do if they were the treating physician. We received responses from 306 physicians from 20 different countries. The heterogeneity...... of the responses highlights the variation in clinical practice and lack of an evidence base in this area and underscores the importance of prospective clinical trials to address this key question in the clinical management of patients with dengue....

  9. Clinical predictors of dengue fever co-infected with leptospirosis among patients admitted for dengue fever - a pilot study.

    Science.gov (United States)

    Suppiah, Jeyanthi; Chan, Shie-Yien; Ng, Min-Wern; Khaw, Yam-Sim; Ching, Siew-Mooi; Mat-Nor, Lailatul Akmar; Ahmad-Najimudin, Naematul Ain; Chee, Hui-Yee

    2017-06-28

    Dengue and leptospirosis infections are currently two major endemics in Malaysia. Owing to the overlapping clinical symptoms between both the diseases, frequent misdiagnosis and confusion of treatment occurs. As a solution, the present work initiated a pilot study to investigate the incidence related to co-infection of leptospirosis among dengue patients. This enables the identification of more parameters to predict the occurrence of co-infection. Two hundred sixty eight serum specimens collected from patients that were diagnosed for dengue fever were confirmed for dengue virus serotyping by real-time polymerase chain reaction. Clinical, laboratory and demographic data were extracted from the hospital database to identify patients with confirmed leptospirosis infection among the dengue patients. Thus, frequency of co-infection was calculated and association of the dataset with dengue-leptospirosis co-infection was statistically determined. The frequency of dengue co-infection with leptospirosis was 4.1%. Male has higher preponderance of developing the co-infection and end result of shock as clinical symptom is more likely present among co-infected cases. It is also noteworthy that, DENV 1 is the common dengue serotype among all cases identified as dengue-leptospirosis co-infection in this study. The increasing incidence of leptospirosis among dengue infected patients has posed the need to precisely identify the presence of co-infection for the betterment of treatment without mistakenly ruling out either one of them. Thus, anticipating the possible clinical symptoms and laboratory results of dengue-leptospirosis co-infection is essential.

  10. Acute disseminated encephalomyelitis in dengue viral infection.

    Science.gov (United States)

    Wan Sulaiman, Wan Aliaa; Inche Mat, Liyana Najwa; Hashim, Hasnur Zaman; Hoo, Fan Kee; Ching, Siew Mooi; Vasudevan, Ramachandran; Mohamed, Mohd Hazmi; Basri, Hamidon

    2017-09-01

    Dengue is the most common arboviral disease affecting many countries worldwide. An RNA virus from the flaviviridae family, dengue has four antigenically distinct serotypes (DEN-1-DEN-4). Neurological involvement in dengue can be classified into dengue encephalopathy immune-mediated syndromes, encephalitis, neuromuscular or dengue muscle dysfunction and neuro-ophthalmic involvement. Acute disseminated encephalomyelitis (ADEM) is an immune mediated acute demyelinating disorder of the central nervous system following recent infection or vaccination. This monophasic illness is characterised by multifocal white matter involvement. Many dengue studies and case reports have linked ADEM with dengue virus infection but the association is still not clear. Therefore, this article is to review and discuss concerning ADEM in dengue as an immune-medicated neurological complication; and the management strategy required based on recent literature. Copyright © 2017 Elsevier Ltd. All rights reserved.

  11. Ensino, tecnologia e preconceito: diário de campo em uma escola destinada ao público LGBTTT no Brasil

    Directory of Open Access Journals (Sweden)

    Renan Antônio Silva

    2017-08-01

    Full Text Available O Programa Federal Brasil “Sem Homofobia” foi lançado pela Secretaria Especial de Direitos Humanos (SEDH em 2004, através do Conselho Nacional de Combate à Discriminação (CNCD. Este programa tem como objetivo combater a violência e a discriminação contra o grupo LGBT e promover cidadania homossexual, questionando temas relativos à homossexualidade em todos os Ministérios do Governo, além de propor políticas que apreciem esta população nas mais variadas esferas, entre elas a educação. No âmbito destas políticas, foi criada em Campinas-SP uma escola voltada para o público LGBTTT, chamada E-JOVEM. Desse modo, este artigo objetiva conhecer a realidade vivida pelos alunos e professores nessa referida escola e as possíveis transformações vividas tanto no âmbito pessoal (aprendizagem, liberdade, entre outros quanto no âmbito coletivo, relativo ao combate à homofobia. Tais mudanças ou não, foram descritas em formato de diário de campo. Além da importância da escola na construção de uma sociedade que valorize a diversidade, o projeto E-JOVEM contempla o uso das novas Tecnologias na Educação, tendo em vista o desenvolvimento de uma sociedade cada vez mais tecnológica e a consequente inserção dessas novas Tecnologias no processo de ensino aprendizagem. Os resultados preliminares apontam que afirmar-se gay ou lésbica é dizer, a princípio, que não viverá segundo o natural e o convencional, que irá experimentar uma forma nova de casamento e família, que não a esperada por pais, tios, avós, etc.

  12. Performance Evaluation of Commercial Dengue Diagnostic Tests for Early Detection of Dengue in Clinical Samples

    Directory of Open Access Journals (Sweden)

    Tuan Nur Akmalina Mat Jusoh

    2017-01-01

    Full Text Available The shattering rise in dengue virus infections globally has created a need for an accurate and validated rapid diagnostic test for this virus. Rapid diagnostic test (RDT and reverse transcription-polymerase chain reaction (RT-PCR diagnostic detection are useful tools for diagnosis of early dengue infection. We prospectively evaluated the diagnostic performance of nonstructural 1 (NS1 RDT and real-time RT-PCR diagnostic kits in 86 patient serum samples. Thirty-six samples were positive for dengue NS1 antigen while the remaining 50 were negative when tested with enzyme-linked immunosorbent assay (ELISA. Commercially available RDTs for NS1 detection, RTK ProDetect™, and SD Bioline showed high sensitivity of 94% and 89%, respectively, compared with ELISA. GenoAmp® Trioplex Real-Time RT-PCR and RealStar® Dengue RT-PCR tests presented a comparable kappa agreement with 0.722. The result obtained from GenoAmp® Real-Time RT-PCR Dengue test showed that 14 samples harbored dengue virus type 1 (DENV-1, 8 samples harbored DENV-2, 2 samples harbored DENV-3, and 1 sample harbored DENV-4. 1 sample had a double infection with DENV-1 and DENV-2. The NS1 RDTs and real-time RT-PCR tests were found to be a useful diagnostic for early and rapid diagnosis of acute dengue and an excellent surveillance tool in our battle against dengue.

  13. Chloroquine use improves dengue-related symptoms

    Directory of Open Access Journals (Sweden)

    Marcos Carvalho Borges

    2013-08-01

    Full Text Available Dengue is the most important arboviral disease in the world. As chloroquine, an antimalarial agent, has shown some antiviral effects, this study evaluated its effect in patients with dengue. A randomised, double-blind study was performed by administering chloroquine or placebo for three days to 129 patients with dengue-related symptoms. Of these patients, 37 were confirmed as having dengue and completed the study; in total, 19 dengue patients received chloroquine and 18 received placebo. There was no significant difference in the duration of the disease or the degree and days of fever. However, 12 patients (63% with confirmed dengue reported a substantial decrease in pain intensity and a great improvement in their ability to perform daily activities (p = 0.0004 while on the medication and the symptoms returned immediately after these patients stopped taking the medication. The same effect was not observed in patients with diseases other than dengue. Therefore, this study shows that patients with dengue treated with chloroquine had an improvement in their quality of life and were able to resume their daily activities. However, as chloroquine did not alter the duration of the disease or the intensity and days of fever, further studies are necessary to confirm the clinical effects and to assess the side effects of chloroquine in dengue patients.

  14. School Psychology in Nova Scotia

    Science.gov (United States)

    King, Sara; McGonnell, Melissa; Noyes, Amira

    2016-01-01

    Registration as a psychologist in Nova Scotia can be at the master's or doctoral level; however, the Nova Scotia Board of Examiners in Psychology has announced a move to the doctoral degree as the entry-level to practice. Many school psychologists in Nova Scotia practice at the master's level; therefore, this change could affect school psychology…

  15. Explosive hydrogen burning in novae

    International Nuclear Information System (INIS)

    Wiescher, M.; Goerres, J.; Thielemann, F.K.; Ritter, H.

    1986-01-01

    Recent observations (nova CrA 81 and Aql 82) reported large enhancements of element abundances beyond CNO nuclei in nova ejecta, which still wait for a clear theoretical explanation. Attempts to interprete these findings include scenarios like nova events on a O-Ne-Mg white dwarf or nuclear processing which enables the transfer of CNO material to heavier nuclei. In the present study we included all available nuclear information on proton-rich unstable nuclei, to update thermo-nuclear reaction rates in explosive hydrogen burning. They are applied in a systematic analysis of explosive hydrogen burning for a variety of temperature conditions, appropriate to nova explosions. We find that (a) for temperatures T>2 10 8 K, pre-existing material in Ne, Al, or Mg can be transferred to heavier nuclei following the flow pattern of a r(apid) p(roton-capture) process (b) for T> or approx.3.5 10 8 K CNO matter can be processed to heavier nuclei (in accordance with previous findings). On the basis of these results it seems unlikely that nova Aql 82 (which shows strong carbon and oxygen enrichment together with heavier elements) can be explained by a nova event on a bare O-Ne-Mg white dwarf but is rather a result of burning with T> or approx.3.5 10 8 K. An application to existing nova models shows a reduced 26 Al production, when compared to earlier predictions. Both conclusions, however, have to be verified by complete nova calculations which include the improved nuclear physics input, presented here. (orig.)

  16. Dengue perinatal

    Directory of Open Access Journals (Sweden)

    Doris Martha Salgado

    2013-08-01

    Full Text Available El dengue es en la actualidad la enfermedad viral más relevante de transmisión vectorial hiperendémica en las Américas. El incremento en el número de casos se ha relacionado con la aparición de dengue durante la gestación y en el periodo neonatal. De acuerdo con la edad de gestación en la que ocurra la infección, podrían presentarse manifestaciones en el feto, como aborto, y en los pacientes a término,dengue neonatal. En este artículo se presenta una reseña de los casos reportados a nivel mundial, y especialmente en las Américas, así como aspectos fisiopatogénicos de la enfermedad.   doi: http://dx.doi.org/10.7705/biomedica.v33i0.1449

  17. Recent Advances in Dengue: Relevance to Puerto Rico

    Science.gov (United States)

    Noyd, David H.; Sharp, Tyler M.

    2015-01-01

    Dengue represents an increasingly important public health challenge in Puerto Rico, with recent epidemics in 2007, 2010, and 2012–2013. Although recent advances in dengue vaccine development offer hope for primary prevention, the role of health professionals in the diagnosis and management of dengue patients is paramount. Case definitions for dengue, dengue with warning signs, and severe dengue provide a framework to guide clinical decision-making. Furthermore, the differentiation between dengue and other acute febrile illnesses, such as leptospirosis and chikungunya, is necessary for the appropriate diagnosis and management of cases. An understanding of dengue epidemiology and surveillance in Puerto Rico provides context for clinicians in epidemic and non-epidemic periods. This review aims to improve health professionals’ ability to diagnose dengue, and as highlight the relevance of recent advances in dengue prevention and management in Puerto Rico. PMID:26061055

  18. Competitividade: uma visão caleidoscópica

    OpenAIRE

    Müller, Geraldo [UNESP

    1994-01-01

    O artigo busca discutir o conceito de competitividade a partir de uma nova realidade mundial, que inclui os fenômenos da globalização e regionalização. O autor procura enfatizar a relação entre a competitividade definida como fenômeno econômico, com um enfoque sociocultural que trabalha com os conceitos de eqüidade, sustentabilidade e valores sociais. This paper aims to discuss the concept of competitiveness based on a different world reality, which includes both globalization and regional...

  19. AS NOVAS MÍDIAS E O ATIVISMO DIGITAL NA PROTEÇÃO DO MEIO AMBIENTE: ANÁLISE DO SITE GREENPEACE.ORG

    Directory of Open Access Journals (Sweden)

    Noemi de Freitas Santos

    2013-04-01

    Full Text Available Os movimentos sociais passam por profundas transformações diante das novas tecnologias de informações. Nesse sentido, surge o ciberativismo, uma forma de militância ativa e atuante através das redes sociais, que possibilita ampliar o espaço de discussão sobre determinado assunto. Assim posto, como instrumento facilitador de debates, as novas mídias dão visibilidade a ideologias e informações, e facilitam o engajamento do cidadão nas ações políticas. O artigo se utiliza de uma abordagem dedutiva e de observação direta junto ao site Greenpeace.org para compreender melhor a disseminação de campanhas públicas desse tradicional movimento ambientalista, e a contribuição na construção da cibercidadania. Diante da análise pode-se perceber que a organização dissemina os debates na esfera pública através da interatividade nas redes sociais.

  20. Uma metodologia de teste de acessibilidade para usuários cegos em ambientes Web

    OpenAIRE

    Chalegre, Virgínia Carvalho

    2011-01-01

    Atualmente, o mundo está na era da inclusão digital e a acessibilidade das páginas Web se tornou uma preocupação global, visto que este ambiente desempenha um papel fundamental no cotidiano das pessoas com deficiência. Este ambiente facilita a vida dessas pessoas, permitindo-lhes criar novas formas de relacionamentos e atividades antes inviáveis. Os criadores de conteúdo Web devem tornar as suas produções compreensíveis e navegáveis. Isto passa não só por uma linguagem clara e simples, mas ta...

  1. Recent advances in understanding dengue

    Science.gov (United States)

    Yacoub, Sophie; Mongkolsapaya, Juthathip; Screaton, Gavin

    2016-01-01

    Dengue is an emerging threat to billions of people worldwide. In the last 20 years, the incidence has increased four-fold and this trend appears to be continuing. Caused by one of four viral serotypes, dengue can present as a wide range of clinical phenotypes with the severe end of the spectrum being defined by a syndrome of capillary leak, coagulopathy, and organ impairment. The pathogenesis of severe disease is thought to be in part immune mediated, but the exact mechanisms remain to be defined. The current treatment of dengue relies on supportive measures with no licensed therapeutics available to date. There have been recent advances in our understanding of a number of areas of dengue research, of which the following will be discussed in this review: the drivers behind the global dengue pandemic, viral structure and epitope binding, risk factors for severe disease and its pathogenesis, as well as the findings of recent clinical trials including therapeutics and vaccines. We conclude with current and future dengue control measures and key areas for future research. PMID:26918159

  2. Recent advances in understanding dengue.

    Science.gov (United States)

    Yacoub, Sophie; Mongkolsapaya, Juthathip; Screaton, Gavin

    2016-01-01

    Dengue is an emerging threat to billions of people worldwide. In the last 20 years, the incidence has increased four-fold and this trend appears to be continuing. Caused by one of four viral serotypes, dengue can present as a wide range of clinical phenotypes with the severe end of the spectrum being defined by a syndrome of capillary leak, coagulopathy, and organ impairment. The pathogenesis of severe disease is thought to be in part immune mediated, but the exact mechanisms remain to be defined. The current treatment of dengue relies on supportive measures with no licensed therapeutics available to date. There have been recent advances in our understanding of a number of areas of dengue research, of which the following will be discussed in this review: the drivers behind the global dengue pandemic, viral structure and epitope binding, risk factors for severe disease and its pathogenesis, as well as the findings of recent clinical trials including therapeutics and vaccines. We conclude with current and future dengue control measures and key areas for future research.

  3. Dengue viruses – an overview

    Directory of Open Access Journals (Sweden)

    Anne Tuiskunen Bäck

    2013-08-01

    Full Text Available Dengue viruses (DENVs cause the most common arthropod-borne viral disease in man with 50–100 million infections per year. Because of the lack of a vaccine and antiviral drugs, the sole measure of control is limiting the Aedes mosquito vectors. DENV infection can be asymptomatic or a self-limited, acute febrile disease ranging in severity. The classical form of dengue fever (DF is characterized by high fever, headache, stomach ache, rash, myalgia, and arthralgia. Severe dengue, dengue hemorrhagic fever (DHF, and dengue shock syndrome (DSS are accompanied by thrombocytopenia, vascular leakage, and hypotension. DSS, which can be fatal, is characterized by systemic shock. Despite intensive research, the underlying mechanisms causing severe dengue is still not well understood partly due to the lack of appropriate animal models of infection and disease. However, even though it is clear that both viral and host factors play important roles in the course of infection, a fundamental knowledge gap still remains to be filled regarding host cell tropism, crucial host immune response mechanisms, and viral markers for virulence.

  4. O impacto das novas mídias para os anunciantes brasileiros

    Directory of Open Access Journals (Sweden)

    Marco Aurelio de Souza Rodrigues

    2012-06-01

    Full Text Available O surgimento das tecnologias digitais permitiu o desenvolvimento de meios de contato inéditos entre empresas e consumidores, as chamadas novas mídias. Capazes de reconfigurar indústrias como a fonográfica e a do cinema, as novas mídias têm também impacto considerável na indústria da publicidade. O subsídio cruzado entre anunciantes, veículos de massa e consumidores, consolidado ao longo do século XX, se vê fragilizado com a popularização de aparelhos como Digital Video Recorders (DVRs, tablets, consoles de videogames e telefones celulares, dispositivos que transferem aos consumidores o poder de regular sua exposição à publicidade. Nesse novo ambiente, mídias tradicionais e novas mídias competem pela preferência de consumidores e pela verba dos anunciantes. Apesar da necessidade dos anunciantes de aferir e rentabilizar campanhas publicitárias, verificou-se que o investimento em veículos tradicionais vem crescendo, enquanto a audiência entregue diminui. Num panorama de mudanças, no presente estudo procura-se identificar que fatores influenciam o processo de compra de mídias por parte dos anunciantes, observando a percepção deles sobre mídias emergentes e tradicionais, seus benefícios e desafios. Para tanto, foi realizada uma pesquisa exploratória, utilizando uma abordagem qualitativa. Entre junho e julho de 2009, foram realizadas entrevistas em profundidade com os profissionais responsáveis pelas campanhas publicitárias de 15 empresas anunciantes de grande porte, atuantes em diversas indústrias. Ao analisar os dados colhidos em campo à luz da literatura estudada sobre o tema, a pesquisa identificou três fatores com forte influência sobre a definição do mix de mídias dos entrevistados: o uso de métricas inadequadas às mídias emergentes, a dependência dos anunciantes com as agências de publicidade e os veículos de massa e os próprios processos internos dos anunciantes.

  5. Dengue fever: diagnosis and treatment.

    Science.gov (United States)

    Wiwanitkit, Viroj

    2010-07-01

    Dengue fever is a common tropical infection. This acute febrile illness can be a deadly infection in cases of severe manifestation, causing dengue hemorrhagic shock. In this brief article, I will summarize and discuss the diagnosis and treatment of this disease. For diagnosis of dengue, most tropical doctors make use of presumptive diagnosis; however, the definite diagnosis should be based on immunodiagnosis or viral study. Focusing on treatment, symptomatic and supportive treatment is the main therapeutic approach. The role of antiviral drugs in the treatment of dengue fever has been limited, but is currently widely studied.

  6. Políticas de inovação em nova chave

    Directory of Open Access Journals (Sweden)

    GLAUCO ARBIX

    Full Text Available RESUMO A crise que corrói o Brasil dificulta a retomada do crescimento e a elevação do patamar de competitividade da economia. A situação se torna mais grave quando confrontada com o avanço tecnológico que toma corpo nos países avançados e em desenvolvimento e que prenunciam mudanças profundas nas economias e na organização da sociedade. É urgente que o Brasil tenha condições básicas para não se distanciar ainda mais desse novo ciclo tecnológico. Este artigo, com base na experiência internacional, defende que, paradoxalmente, nos momentos de crise é que os países e empresas mais precisam aumentar seu investimento em inovação. Mais ainda, sugere que o Estado precisa se articular com a iniciativa privada, de modo a formar uma coalização entre empresas, universidades e governo, para enfrentar os desafios tecnológicos que sacodem as economias pelo mundo afora. Essas novas tendências, ainda inacessíveis à maior parte dos países emergentes, apontam para a formação de uma nova economia, articulada em torno de três grandes pilares: digitalização, integração e automação. É urgente a definição de estratégias de longa duração para que o país recupere protagonismo internacional e se destaque por sua inteligência e capacidade de fazer CT&I de alta qualidade.

  7. Serodiagnosis of dengue infection using rapid immunochromatography test in patients with probable dengue infection.

    Science.gov (United States)

    Kidwai, Aneela Altaf; Jamal, Qaiser; Saher; Mehrunnisa; Farooqi, Faiz-ur-rehman; Saleem-Ullah

    2010-11-01

    To determine the frequency of seropositive dengue infection using rapid immunochromatographic assay in patients with probable dengue infection as per WHO criteria. A cross-sectional observational study was conducted at Abbasi Shaheed Hospital, Karachi from July 2008 to January 2009. Patients presenting with acute febrile illness, rashes, bleeding tendencies, leucopenia and or thrombocytopenia were evaluated according to WHO criteria for probable dengue infection. Acute phase sera were collected after 5 days of the onset of fever as per WHO criteria. Serology was performed using rapid immunochromatographic (ICT) assay with differential detection of IgM and IgG. A primary dengue infection was defined by a positive IgM band and a negative IgG band whereas secondary infection was defined by a positive IgG band with or without positive IgM band. Among 599 patients who met the WHO criteria for dengue infection, 251(41.9%) were found to be ICT reactive among whom 42 (16.73%) had primary infection. Secondary infection was reported in 209 (83.26%). Acute phase sera of 348 (58.09%) were ICT non reactive. Four patients died because of dengue shock syndrome among which three had secondary infection. Early identification of secondary infection in acute phase sera using rapid ICT is valuable in terms of disease progression and mortality. However in highly suspected cases of dengue infection clinical management should not rely on negative serological results.

  8. Dengue: an arthropod-borne disease of global importance.

    NARCIS (Netherlands)

    Mairuhu, A.T.; Wagenaar, J.; Brandjes, D.P.; Gorp, E. van

    2004-01-01

    Dengue viruses cause a variable spectrum of disease that ranges from an undifferentiated fever to dengue fever to the potentially fatal dengue shock syndrome. Due to the increased incidence and geographical distribution of dengue in the last 50 years, dengue is becoming increasingly recognised as

  9. Coexistência de redes de acesso de nova geração

    OpenAIRE

    Viana, Diogo Fernando Rebelo

    2013-01-01

    Nos dias que correm assiste-se a um contínuo crescimento do consumo de conteúdos que exigem uma maior largura banda disponível para cada utilizador o que leva ao investimento, por parte dos operadores de telecomunicações, na procura de novas soluções no domínio ótico. Desta procura surgiram as redes óticas passivas (PON: Passive Optical Network) que se iniciaram com as G-PON (Gigabit PON), que mais tarde evoluíram para as XG-PON (10-Gigabit PON) e que atualmente se encontram em fase de migraç...

  10. Ongoing dengue epidemic - Angola, June 2013.

    Science.gov (United States)

    2013-06-21

    On April 1, 2013, the Public Health Directorate of Angola announced that six cases of dengue had been reported to the Ministry of Health of Angola (MHA). As of May 31, a total of 517 suspected dengue cases had been reported and tested for dengue with a rapid diagnostic test (RDT). A total of 313 (60.5%) specimens tested positive for dengue, including one from a patient who died. All suspected cases were reported from Luanda Province, except for two from Malanje Province. Confirmatory diagnostic testing of 49 specimens (43 RDT-positive and six RDT-negative) at the CDC Dengue Branch confirmed dengue virus (DENV) infection in 100% of the RDT-positive specimens and 50% of the RDT-negative specimens. Only DENV-1 was detected by molecular diagnostic testing. Phylogenetic analysis indicated this virus has been circulating in the region since at least 1968, strongly suggesting that dengue is endemic in Angola. Health-care professionals throughout Angola should be aware of the ongoing epidemic, the recommended practices for clinical management of dengue patients, and the need to report cases to MHA. Persons in Angola should seek medical care for acute febrile illness to reduce the risk for developing complications. Laboratory-confirmed dengue also has been reported from seven countries on four continents among persons who had recently traveled to Luanda, including 79 persons from Portugal. Angola is the third of four African countries to report a dengue outbreak in 2013. Persons returning from Africa with acute febrile illness should seek medical care, including testing for DENV infection, and suspected cases should be reported to public health authorities.

  11. Searching for nova shells around cataclysmic variables

    Science.gov (United States)

    Sahman, D. I.; Dhillon, V. S.; Knigge, C.; Marsh, T. R.

    2015-08-01

    We present the results of a search for nova shells around 101 cataclysmic variables (CVs), using H α images taken with the 4.2-m William Herschel Telescope (WHT) and the 2.5-m Isaac Newton Telescope Photometric H α Survey of the Northern Galactic Plane (IPHAS). Both telescopes are located on La Palma. We concentrated our WHT search on nova-like variables, whilst our IPHAS search covered all CVs in the IPHAS footprint. We found one shell out of the 24 nova-like variables we examined. The newly discovered shell is around V1315 Aql and has a radius of ˜2.5 arcmin, indicative of a nova eruption approximately 120 yr ago. This result is consistent with the idea that the high mass-transfer rate exhibited by nova-like variables is due to enhanced irradiation of the secondary by the hot white dwarf following a recent nova eruption. The implications of our observations for the lifetime of the nova-like variable phase are discussed. We also examined four asynchronous polars, but found no new shells around any of them, so we are unable to confirm that a recent nova eruption is the cause of the asynchronicity in the white dwarf spin. We find tentative evidence of a faint shell around the dwarf nova V1363 Cyg. In addition, we find evidence for a light echo around the nova V2275 Cyg, which erupted in 2001, indicative of an earlier nova eruption ˜300 yr ago, making V2275 Cyg a possible recurrent nova.

  12. Sofosbuvir as treatment against dengue?

    Science.gov (United States)

    Gan, Chye Sheng; Lim, See Khai; Chee, Chin Fei; Yusof, Rohana; Heh, Choon Han

    2018-02-01

    Dengvaxia ® (CTD-TDV), the only licensed tetravalent dengue vaccine by Sanofi Pasteur, was made available since 2015. However, administration of CTD-TDV, in general, has not received the prequalification recommendation from the World Health Organization. Having a universal antidengue agent for treatment will therefore beneficial. Accordingly, the development of nucleoside inhibitors specific to dengue viral polymerase that perturb dengue infection has been studied by many. Alternatively, we have used a marketed anti-HCV prodrug sofosbuvir to study its in silico and in vitro effects against dengue. As a result, the active metabolite of sofosbuvir (GS-461203) was predicted to bind to the catalytic motif (Gly-Asp-Asp) of dengue viral polymerase with binding affinity of -6.9 kcal/mol. Furthermore, sofosbuvir demonstrated excellent in vitro viral inhibition with an EC 90 of 0.4 μm. In addition, this study demonstrated the requirement of specific liver enzymes to activate the prodrug into GS-461203 to exert its antidengue potential. All in all, sofosbuvir should be subjected to in-depth studies to provide information of its efficacy toward dengue and its lead potential as DENV polymerase inhibitor in human subjects. In conclusion, we have expended the potential of the clinically available drug sofosbuvir as treatment for dengue. © 2017 John Wiley & Sons A/S.

  13. A nova gestão pública na Inglaterra: a permanente instabilidade da reforma neoliberal

    Directory of Open Access Journals (Sweden)

    David Hall

    2015-09-01

    Full Text Available RESUMO: A reforma da educação na Inglaterra tem sido intimamente associada a um programa mais amplo da nova gestão pública, centrado na reforma dos serviços públicos. Este artigo analisa as características deste programa de reformas inspirado na NGP, tendo em vista que o sistema educacional inglês se deslocou de uma forma cívica e de proteção social ("cívico-welfarista" para um modo em que o neoliberalismo despontou em ascendência. Atenção particular é dada tanto aos aspectos centralizadores da reforma, em que tem havido um acentuado aumento na intervenção do governo central na educação, quanto aos aspectos descentralizadores da reforma, incluindo a criação de escolas como unidades de negócios e a mercantilização da educação em termos mais gerais. As origens das reformas estão situadas em uma construção discursiva de uma crise educacional, inspirada na Nova Direita, que encontrou posterior expressão em uma série de alterações na legislação que emergiram de e cimentaram um consenso educacional trans-político-partidário que já perdura por mais de trinta anos neste contexto. Este artigo examina os efeitos dessas reformas da NGP na educação na Inglaterra, e as continuidades e descontinuidades entre as diferentes administrações políticas, considerando que a Inglaterra passou por sucessivas ondas de reformas até chegarmos a um período pós-NGP. Concluímos que a permanente instabilidade do sistema educacional inglês pode ser identificado nas tensões que atingem o próprio âmago do processo da NGP, de formas que, antecipamos, continuarão a perturbar um setor rapidamente privatizador.

  14. Desarrollo de agentes inmunizantes contra el dengue Development of immunizing agents against dengue

    Directory of Open Access Journals (Sweden)

    Francisco J. López Antuñano

    2000-05-01

    Full Text Available El complejo de los cuatro flavivirus del dengue es transmitido principalmente por el mosquito Aedes aegypti. Se han atribuido epidemias a la actividad de A. albopictus, A. polynesiensis y a varias especies del complejo A. scutellaris. Los factores de riesgo que determinan la probabilidad de enfermar o morir por dengue están relacionados tanto con el huésped (características genéticas, estado inmunitario, forma de vida y condiciones de salud, saneamiento básico de la vivienda y abastecimiento de agua potable como con el virus (variabilidad genética de cepas entre y dentro de los serotipos, diferente capacidad patógena y distribución geográfica. A pesar de la falta de conocimiento sobre la inmunobiopatología del dengue, se han hecho importantes avances para conseguir una respuesta inmunitaria protectora con virus atenuados y con antígenos obtenidos por medio de tecnologías recombinantes. Desde los años 40, se ha intentado desarrollar vacunas contra el dengue. La inmunidad que se adquiere por infección natural es específica para cada serotipo y se han documentado infecciones por tres serotipos diferentes en la misma persona, por lo que probablemente sea necesaria una vacuna tetravalente. En voluntarios se han probado vacunas contra los cuatro serotipos que han sido inmunógenas y seguras. Aunque las vacunas con virus atenuados son prometedoras, son necesarios nuevos estudios sobre su eficacia y seguridad. Actualmente están en curso estudios para producir vacunas contra el virus del dengue mediante tecnologías de ADN recombinante y otras técnicas de biología molecular, utilizando como antígenos proteínas estructurales (principalmente la glicoproteína E y no estructurales. Con el mismo propósito se han usado varios vectores de expresión, como Escherichia coli, baculovirus, virus de la vacuna y virus de la fiebre amarilla. Lamentablemente, no se han obtenido resultados satisfactorios en el hombre. La necesidad de desarrollar

  15. Avaliação integrada do impacto do uso de agrotóxicos sobre a saúde humana em uma comunidade agrícola de Nova Friburgo, RJ

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    Josino C. Moreira

    Full Text Available O impacto do uso de agrotóxicos sobre a saúde humana é um problema que tem merecido atenção da comunidade científica em todo o mundo, sobretudo nos países em desenvolvimento. O consumo de agrotóxicos na região sudeste do Brasil está estimado em 12kg de agrotóxico/trabalhador/ano. Em algumas áreas agrícolas do Estado do Rio de Janeiro, como na região da Microbacia do Córrego de São Lourenço, Nova Friburgo, o consumo de agrotóxico foi estimado em 56kg de agrotóxico/trabalhador/ano. Elevados níveis de contaminação humana e ambiental foram encontrados nesta região, como decorrência do uso extensivo destes agentes químicos. A avaliação do impacto sobre a saúde humana implica o conhecimento e a visualização da importância/magnitude relativa de cada uma das vias de contaminação. Inúmeros fatores, que, em geral, encontram-se inter-relacionados, contribuem para a situação encontrada na Microbacia do Córrego de São Lourenço e a forma mais adequada de se avaliar toda a dimensão deste problema é o uso de uma abordagem integrada.

  16. A natureza motivacional dos valores humanos: evidências acerca de uma nova tipologia The motivational nature of human values: evidence of a new typology

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    Valdiney V. Gouveia

    2003-12-01

    Full Text Available Este artigo apresenta uma tipologia nova dos valores básicos, fundamentada nas necessidades humanas. Tais valores representam teoricamente três critérios de orientação, cada um subdividido em duas funções psicossociais: pessoal (experimentação e realização, central (existência e suprapessoal e social (interacional e normativa. Foram consideradas duas amostras diversificadas (N = 606. Esta tipologia foi testada em relação aos seguintes aspectos: (1 estrutura interna - uma análise de escalonamento multidimensional (MDS permitiu visualizar os três critérios de orientação teorizados, e uma análise fatorial confirmatória comprovou a existência das suas respectivas funções psicossociais; (2 convergência com a teoria de Schwartz - uma MDS mostrou que as seis funções psicossociais e os dez tipos motivacionais de valores aparecem em diferentes regiões espaciais, porém podem ser interpretados nos mesmos termos; e (3 predição do grau de religiosidade - consistentemente, esta variável se correlacionou em sentido positivo e negativo, respectivamente, com os valores normativos e de experimentação. Em suma, esta tipologia não é incompatível com a que propõe Schwartz, referendando a natureza motivacional dos valores humanos. Não obstante, tem a vantagem de ser mais parcimoniosa, assumindo um menor número de valores básicos.This article presents a new typology of basic values, based on human needs. Such values were theorized to represent three criteria of orientation, each one divided in two psychosocial functions: personal (experiential and promotion, central (preservation and supra-personal, and social (interactional and normative. Data were obtained from two diverse samples (N = 606. This typology was tested regarding to: (1 internal structure - a multidimensional scaling (MDS permitted viewing these three criteria of orientation, and a confirmatory factor analysis proved their corresponding psychosocial functions; (2

  17. Dengue fever: a Wikipedia clinical review

    OpenAIRE

    Heilman, James M; Wolff, Jacob De; Beards, Graham M; Basden, Brian J

    2014-01-01

    Dengue fever, also known as breakbone fever, is a mosquito-borne infectious tropical disease caused by the dengue virus. Symptoms include fever, headache, muscle and joint pains, and a characteristic skin rash that is similar to measles. In a small proportion of cases, the disease develops into life-threatening dengue hemorrhagic fever, which results in bleeding, thrombocytopenia, and leakage of blood plasma, or into dengue shock syndrome, in which dangerously low blood pressure occurs. Treat...

  18. Dengue, Zika y Chikungunya

    OpenAIRE

    Kantor, Isabel N

    2016-01-01

    Los responsables de la actual pandemia de Chikungunya (alfavirus), dengue y Zika (flavivirus) son virus trasmitidos por artrópodos, arbovirus. Su importancia aumentó en las Américas en los últimos 20 años. Los vectores principales son Aedes aegypti y A. albopictus. La infección por dengue provee inmunidad duradera al serotipo específico y temporaria a otros tres. La posterior infección por otro serotipo determina mayor gravedad. Existe una vacuna contra dengue registrada, Dengvaxia (Sanofi Pa...

  19. Relationship of classical novae to other eruptive variables

    International Nuclear Information System (INIS)

    Vogt, N.

    1989-01-01

    Classical novae are characterized by their well known large-amplitude outbursts, accompanied by the ejection of a shell. The same stars, however, apparently pass through much longer quiescent phases whose duration exceeds that of the outburst phase by a factor ∼ 10 5 and that of historical nova records by a factor 10 2 -10 3 . Therefore a large number of variable stars should exist which actually are classical nova systems but whose last outbursts occurred in prehistoric times. We assume that some of these stars are hidden among the so-called 'nova-lies' in the literature. However some eruptive variables and symbiotic stars, i.e. stars which certainly are not nova remnants, are mentioned. Variables related to classical novae can be divided into three main classes: (i) Potential novae which are possibly classical novae in their quiescent state. Potential novae must share the basic configuration and parameters (orbital period, masses) with classical novae; they must be semi-detached cataclysmic binaries with a white dwarf as primary and a Roche-lobe-filling red dwarf on, or near, the mainsequence as secondary. (ii) Stars which share some outburst characteristics with classical novae without having the same binary configuration. For example recurrent novae with giant secondaries, very slow novae (and symbiotic binary stars). (iii) Stars which are evolutionarily related to classical novae, i.e. which possibly are progenitors or successors of novae in their secular evolution, such as binary nuclei of planetary nebulae and close, but detached, white dwarf-red dwarf pairs (e.g. V 471 Tau), both resulting from common-envelope evolution. These three main groups of nova-related stars are discussed. (author)

  20. Dengue virus transovarial transmission by Aedes aegypti

    Directory of Open Access Journals (Sweden)

    Monica Dwi Hartanti

    2016-02-01

    Full Text Available Dengue is a disease that is caused by dengue virus and transmitted to humans through the bite of infected Aedes mosquitoes, especially Aedes aegypti. The disease is hyper-endemic in Southeast Asia, where a more severe form, dengue hemorrhagic fever (DHF and dengue shock syndrome (DSS, is a major public health concern. The purpose of the present study was to find evidence of dengue virus transovarial transmision in local vectors in Jakarta. Fifteen Aedes larvae were collected in 2009 from two areas in Tebet subdistrict in South Jakarta, namely one area with the highest and one with the lowest DHF prevalence. All mosquitoes were reared inside two cages in the laboratory, eight mosquitoes in one cage and seven mosquitoes in another cage and given only sucrose solution as their food. The results showed that 20% of the mosquitoes were positive for dengue virus. Dengue virus detection with an immunohistochemical method demonstrated the occurrence of transovarial transmission in local DHF vectors in Tebet subdistrict. Transovarial dengue infection in Ae.aegypti larvae appeared to maintain or enhance epidemics. Further research is needed to investigate the relation of dengue virus transovarial transmission with DHF endemicity in Jakarta.

  1. Dengue virus transovarial transmission by Aedes aegypti

    Directory of Open Access Journals (Sweden)

    Monica Dwi Hartanti

    2010-08-01

    Full Text Available Dengue is a disease that is caused by dengue virus and transmitted to humans through the bite of infected Aedes mosquitoes, especially Aedes aegypti. The disease is hyper-endemic in Southeast Asia, where a more severe form, dengue hemorrhagic fever (DHF and dengue shock syndrome (DSS, is a major public health concern. The purpose of the present study was to find evidence of dengue virus transovarial transmision in local vectors in Jakarta. Fifteen Aedes larvae were collected in 2009 from two areas in Tebet subdistrict in South Jakarta, namely one area with the highest and one with the lowest DHF prevalence. All mosquitoes were reared inside two cages in the laboratory, eight mosquitoes in one cage and seven mosquitoes in another cage and given only sucrose solution as their food. The results showed that 20% of the mosquitoes were positive for dengue virus. Dengue virus detection with an immunohistochemical method demonstrated the occurrence of transovarial transmission in local DHF vectors in Tebet subdistrict. Transovarial dengue infection in Ae.aegypti larvae appeared to maintain or enhance epidemics. Further research is needed to investigate the relation of dengue virus transovarial transmission with DHF endemicity in Jakarta.

  2. Appendicular perforation in dengue fever: our experience

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    Gunjan Desai

    2014-09-01

    Full Text Available Dengue viral infections have become one of major emerging infectious diseases in the tropics. Acute abdomen occurring in dengue viral infection is not uncommon. The spectrums of acute surgical emergencies which raise suspicion of an abdominal catastrophe in patients presenting with dengue fever include acute pancreatitis, acute acalculous cholecystitis, non-specific peritonitis and very rarely acute appendicitis. The presence of low white cell count and platelet count can raise suspicion of a diagnosis of dengue in a patient presenting with acute abdominal pain, during a dengue epidemic. We herein report three patients with dengue fever who had appendicular perforation during the course of their viral fever.

  3. Treatment of dengue fever

    Directory of Open Access Journals (Sweden)

    Rajapakse S

    2012-07-01

    Full Text Available Senaka Rajapakse,1,2 Chaturaka Rodrigo,1 Anoja Rajapakse31Department of Clinical Medicine, Faculty of Medicine, University of Colombo, Sri Lanka; 2Lincoln County Hospital, United Lincolnshire NHS Trust, Lincoln, UK; 3Kings Mill Hospital, Sherwood Forest NHS Foundation Trust, Mansfield, UKAbstract: The endemic area for dengue fever extends over 60 countries, and approximately 2.5 billion people are at risk of infection. The incidence of dengue has multiplied many times over the last five decades at an alarming rate. In the endemic areas, waves of infection occur in epidemics, with thousands of individuals affected, creating a huge burden on the limited resources of a country's health care system. While the illness passes off as a simple febrile episode in many, a few have a severe illness marked by hypovolemic shock and bleeding. Iatrogenic fluid overload in the management may further complicate the picture. In this severe form dengue can be fatal. Tackling the burden of dengue is impeded by several issues, including a lack of understanding about the exact pathophysiology of the infection, inability to successfully control the vector population, lack of specific therapy against the virus, and the technical difficulties in developing a vaccine. This review provides an overview on the epidemiology, natural history, management strategies, and future directions for research on dengue, including the potential for development of a vaccine.Keywords: dengue, treatment, fluid resuscitation

  4. Observations of classical novae in outburst

    Science.gov (United States)

    Starrfield, S.; Stryker, L. L.; Sonneborn, G.; Sparks, Warren M.; Ferland, Gary; Wagner, R. M.; Williams, R. E.; Gehrz, Robert D.; Ney, Edward P.; Kenyon, Scott

    1988-01-01

    The IUE obtained ultraviolet data on novae in outburst. The characteristics of every one of the outbursts are different. Optical and infrared data on many of the same novae were also obtained. Three members of the carbon-oxygen class of novae are presented.

  5. Roles for Endothelial Cells in Dengue Virus Infection

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    Nadine A. Dalrymple

    2012-01-01

    Full Text Available Dengue viruses cause two severe diseases that alter vascular fluid barrier functions, dengue hemorrhagic fever (DHF and dengue shock syndrome (DSS. The endothelium is the primary fluid barrier of the vasculature and ultimately the effects of dengue virus infection that cause capillary leakage impact endothelial cell (EC barrier functions. The ability of dengue virus to infect the endothelium provides a direct means for dengue to alter capillary permeability, permit virus replication, and induce responses that recruit immune cells to the endothelium. Recent studies focused on dengue virus infection of primary ECs have demonstrated that ECs are efficiently infected, rapidly produce viral progeny, and elicit immune enhancing cytokine responses that may contribute to pathogenesis. Furthermore, infected ECs have also been implicated in enhancing viremia and immunopathogenesis within murine dengue disease models. Thus dengue-infected ECs have the potential to directly contribute to immune enhancement, capillary permeability, viremia, and immune targeting of the endothelium. These effects implicate responses of the infected endothelium in dengue pathogenesis and rationalize therapeutic targeting of the endothelium and EC responses as a means of reducing the severity of dengue virus disease.

  6. Current management of severe dengue infection.

    Science.gov (United States)

    Lee, Tau Hong; Lee, Linda Kay; Lye, David Chien; Leo, Yee Sin

    2017-01-01

    Traditionally a disease mainly affecting the pediatric population, dengue burden has increased significantly in recent decades and adults with severe disease may become more common. There is currently no effective anti-viral agent available for the treatment of dengue and supportive care is the mainstay of management. Areas covered: We present a review of current literature on dengue severity classification systems and the management of severe dengue in adults. In particular, emphasis was placed on organ impairment in dengue and management of elderly individuals with multiple medical problems. Expert commentary: There is an urgent need to search for an effective anti-viral agent to treat infected individuals. The commercial availability of a dengue vaccine in older children has provided optimism in reducing the disease burden but long term efficacy and safety are unknown. The results from phase III trials of two new candidate vaccines are eagerly awaited.

  7. RNAi: antiviral therapy against dengue virus.

    Science.gov (United States)

    Idrees, Sobia; Ashfaq, Usman A

    2013-03-01

    Dengue virus infection has become a global threat affecting around 100 countries in the world. Currently, there is no licensed antiviral agent available against dengue. Thus, there is a strong need to develop therapeutic strategies that can tackle this life threatening disease. RNA interference is an important and effective gene silencing process which degrades targeted RNA by a sequence specific process. Several studies have been conducted during the last decade to evaluate the efficiency of siRNA in inhibiting dengue virus replication. This review summarizes siRNAs as a therapeutic approach against dengue virus serotypes and concludes that siRNAs against virus and host genes can be next generation treatment of dengue virus infection.

  8. Cost of Dengue Vector Control Activities in Malaysia

    Science.gov (United States)

    Packierisamy, P. Raviwharmman; Ng, Chiu-Wan; Dahlui, Maznah; Inbaraj, Jonathan; Balan, Venugopalan K.; Halasa, Yara A.; Shepard, Donald S.

    2015-01-01

    Dengue fever, an arbovirus disease transmitted by Aedes mosquitoes, has recently spread rapidly, especially in the tropical countries of the Americas and Asia-Pacific regions. It is endemic in Malaysia, with an annual average of 37,937 reported dengue cases from 2007 to 2012. This study measured the overall economic impact of dengue in Malaysia, and estimated the costs of dengue prevention. In 2010, Malaysia spent US$73.5 million or 0.03% of the country's GDP on its National Dengue Vector Control Program. This spending represented US$1,591 per reported dengue case and US$2.68 per capita population. Most (92.2%) of this spending occurred in districts, primarily for fogging. A previous paper estimated the annual cost of dengue illness in the country at US$102.2 million. Thus, the inclusion of preventive activities increases the substantial estimated cost of dengue to US$175.7 million, or 72% above illness costs alone. If innovative technologies for dengue vector control prove efficacious, and a dengue vaccine was introduced, substantial existing spending could be rechanneled to fund them. PMID:26416116

  9. Disc structure and variability in dwarf novae

    Science.gov (United States)

    Harlaftis, Emilios Theofanus

    An introduction is given to dwarf novae reviewing the current research status in the field. We present IUE observations of Z Cha which support the mass transfer instability as the cause of the superoutbursts observed in SU UMa type dwarf novae. Comparison between the superoutburst and a normal outburst of Z Cha shows that the disc is flatter and has significantly less azimuthal structure than during superoutburst. Z Cha exhibits a soft x-ray deficit during superoutburst compared to OY Car. We find that the secondary star of Z Cha contributes approximately 30 percent of the infrared flux at peak of outburst. The second part of the thesis presents results from the 1988 International Time Project at the Observatorio del Roque de los Muchachos. Investigation of the behavior of SU UMa and YZ Cnc is carried out through the outburst cycle. The secular changes of the equivalent widths of both systems shows an increasing trend even during quiescence and are caused by the continuum decrease. Both systems show a low-velocity emission component which contaminates the wings of the H(alpha) profile. In addition to doppler broadening, the Stark effect is found to cause significant broadening to the line profile. The radial dependence of the emission lines is discussed in relation to other cataclysmic variables. H(alpha) emission from the secondary star of YZ Cnc is found during superoutburst, during outburst and during quiescence after outburst. Photometry during late decline of outburst shows a sinusoidal, weak variation peaking at 0.5 orbital phase and which is related to heating of the red star or to a transient disc event. During quiescence, the flickering is found to be caused by the bright spot. This modulation increases with time and is maximum before the outburst. Doppler tomography of IP Peg during quiescence reveals an emission line distribution not consistent to the standard model. We find Balmer emission from the secondary star, at a level of only 2.5 percent of the

  10. Um desafio para a saúde pública brasileira: o controle do dengue

    Directory of Open Access Journals (Sweden)

    Maria Lucia F. Penna

    2003-02-01

    Full Text Available Este artigo problematiza a estratégia tradicional de controle do Aedes aegypti por meio do trabalho de guardas sanitários, com visitas periódicas a todas as edificações urbanas. Ela não é viável e/ou não tem factibilidade administrativa atualmente, já que vem sendo proposta desde a década de 80 e não é implementada. A reforma sanitária brasileira priorizou a ampliação da cobertura dos serviços básicos de saúde e não as ações de controle de doenças específicas. O A. aegypti reintroduzido para iniciar a reocupação de seu antigo habitat em 1976, está atualmente em um processo de reocupação do país até atingir seu equilíbrio Isto como problema de saúde coletiva, diz respeito ao meio ambiente urbano, portanto um problema de todos, população e poder público, não apenas da área de saúde. A necessidade da atuação conjunta da área de saneamento e meio ambiente neste caso é ressaltada. Deve-se também repensar a contribuição da população como efetiva e permanente, separando obrigações e direitos do poder público e da população, separando o público do privado. O perigo do reaparecimento da febre amarela deve ser considerado no estabelecimento de uma nova estratégia factível e viável para lidar com o problema do dengue.

  11. Novas formas econômicas: um relato das terras altas da Papua-Nova Guiné

    Directory of Open Access Journals (Sweden)

    Marilyn Strathern

    1998-04-01

    Full Text Available Se a inflação em uma economia de mercado implica reajustes na proporção entre bens e dinheiro, a inflação em uma economia do dom deve implicar reajustes na proporção na qual são produzidas as relações. Este artigo trata das mudanças ocorridas nas terras altas da Nova Guiné, nos últimos trinta anos, e de como poder-se-ia interpretar o modo pelo qual certas relações estão se desenvolvendo. Estas relações são aquelas entre clãs, parentes e sexos. Ainda que o artigo abarque três horizontes temporais nesse período, ele é escrito deliberadamente da perspectiva de como o presente (a década de 90 apresenta-se a partir do passado (a década de 60.If inflation in a commodity economy implies a readjustment in the ratio of goods and money, then inflation in a gift economy must imply a readjustment in the rate by which relationships are produced. This article considers changes in the New Guinea Highlands over the last 30 years, and how one might interpret the manner in which certain relatioships are evolving. These are relations between clans, among kin and across the sexes. While the article considers three time horizonts over this period, it is deliberately written from the perspective of how the present (1990's looks from the past (1960's.

  12. [Hepatic alterations in patients with dengue].

    Science.gov (United States)

    Larreal, Yraima; Valero, Nereida; Estévez, Jesús; Reyes, Ivette; Maldonado, Mery; Espina, Luz Marina; Arias, Julia; Meleán, Eddy; Añez, German; Atencio, Ricardo

    2005-06-01

    Clinical features of Dengue are very variable due to multiple alterations induced by the virus in the organism. Increased levels of transaminases similar to those produced by the Hepatitis virus have been reported in patients with Dengue from hiperendemic zones in Asia. The objectives of this study were to determine alterations in the liver tests in patients with Dengue and to relate them to the disease, clinically and serologically. Clinical history, hemathological tests serum transaminases (ALT y AST) and bilirubin assays were performed in 62 patients with clinical and serological diagnosis of Dengue. According to clinical features 38.7% of the patients with classical (CD) and hemorrhagic (DHF) forms of Dengue reffered abdominal pain and 2 patients with DHF had ictericia and hepatomegaly. Laboratory test findings showed leucopenia in 72.5% in both forms of Dengue and of patients with DHF severe thrombocytopenia (< 50.000 platelets x mm3), long PT and PPT in 70.9%, 23.0% and 42.3%, respectively. Transaminase values five fold higher than the normal values (p < 0.005) were observed in 36.8% and 74.4% of patients with CD and DHF respectively; AST was predominant in both groups. Our results suggest liver damage during the course of Dengue. A differential diagnosis has to be done between the hepatic involvement of Dengue cases and others viral diseases with hepatic disfunctions.

  13. Uma abordagem arquitetural para o desenvolvimento rigoroso de sistemas confiáveis baseados em componentes

    OpenAIRE

    Patrick Henrique da Silva Brito

    2009-01-01

    Resumo: A incorporação de tolerância a falhas em sistemas de software normalmente acarreta em um aumento da complexidade, o que consequentemente torna a sua análise mais difícil. Além disso, o uso de mecanismos de tratamento de exceções de uma maneira não-sistemática pode acarretar na adição de novas falhas ao sistema. Esta tese apresenta uma abordagem rigorosa e centrada na arquitetura para o desenvolvimento de sistemas de software tolerantes a falhas. Dependendo do modelo de falhas e da dis...

  14. Poder de mercado no segmento de distribuição de gasolina C: uma análise a partir da Nova Organização Industrial Empírica

    Directory of Open Access Journals (Sweden)

    Rosangela Aparecida Soares Fernandes

    2013-09-01

    Full Text Available Este artigo tem como objetivo avaliar o grau de poder de mercado no setor de distribuição de gasolina C, nas regiões brasileiras, no período de 2002 a 2008. Para tal, baseou-se na Teoria da Nova Organização Industrial Empírica (NOIE, especificamente, no modelo proposto por Bresnahan (1982 e Lau (1982. Uma versão dinâmica do modelo também foi estimada. Os resultados indicaram que, exceto para a região Norte, para o modelo estático, as empresas distribuidoras de gasolina C não agem como tomadoras de preços (Λ = 0. No outro extremo, a hipótese de conluio perfeito (Λ = 1 entre elas foi rejeitada. Verificou-se que, em várias regiões, os parâmetros revelaram-se suficientemente baixos, sugerindo que as empresas distribuidoras apresentam elevada competição entre si.

  15. Dengue virus markers of virulence and pathogenicity

    OpenAIRE

    Rico-Hesse, Rebeca

    2009-01-01

    The increased spread of dengue fever and its more severe form, dengue hemorrhagic fever, have made the study of the mosquito-borne dengue viruses that cause these diseases a public health priority. Little is known about how or why the four different (serotypes 1–4) dengue viruses cause pathology in humans only, and there have been no animal models of disease to date. Therefore, there are no vaccines or antivirals to prevent or treat infection and mortality rates of dengue hemorrhagic fever pa...

  16. Hemophagocytic syndrome in classic dengue fever

    Directory of Open Access Journals (Sweden)

    Sayantan Ray

    2011-01-01

    Full Text Available A 24-year-old previously healthy girl presented with persistent fever, headache, and jaundice. Rapid-test anti-dengue virus IgM antibody was positive but anti-dengue IgG was nonreactive, which is suggestive of primary dengue infection. There was clinical deterioration during empiric antibiotic and symptomatic therapy. Bone marrow examination demonstrated the presence of hemophagocytosis. Diagnosis of dengue fever with virus-associated hemophagocytic syndrome was made according to the diagnostic criteria of the HLH 2004 protocol of the Histiocyte Society. The patient recovered with corticosteroid therapy. A review of literature revealed only a handful of case reports that showed the evidence that this syndrome is caused by dengue virus. Our patient is an interesting case of hemophagocytic syndrome associated with classic dengue fever and contributes an additional case to the existing literature on this topic. This case highlights the need for increased awareness even in infections not typically associated with hemophagocytic syndrome.

  17. Serodiagnosis of dengue infection using rapid immuno chromatography test in patients with probable dengue infection

    International Nuclear Information System (INIS)

    Kidwai, A.A.; Jamal, Q.; Mehrunnisa, S.; Farooqi, F.R.

    2010-01-01

    Objective: To determine the frequency of seropositive dengue infection using rapid immuno chromatographic assay in patients with probable dengue infection as per WHO criteria. Method: A cross-sectional observational study was conducted at Abbasi Shaheed Hospital, Karachi from July 2008 to January 2009. Patients presenting with acute febrile illness, rashes, bleeding tendencies, leucopenia and or thrombocytopenia were evaluated according to WHO criteria for probable dengue infection. Acute phase sera were collected after 5 days of the onset of fever as per WHO criteria. Serology was performed using rapid immuno chromatographic (ICT) assay with differential detection of IgM and IgG. A primary dengue infection was defined by a positive IgM band and a negative IgG band whereas secondary infection was defined by a positive IgG band with or without positive IgM band. Result: Among 599 patients who met the WHO criteria for dengue infection, 251(41.9%) were found to be ICT reactive among whom 42 (16.73%) had primary infection. Secondary infection was reported in 209 (83.26%). Acute phase sera of 348 (58.09%) were ICT non reactive. Four patients died because of dengue shock syndrome among which three had secondary infection. Conclusion: Early identification of secondary infection in acute phase sera using rapid ICT is valuable in terms of disease progression and mortality. However in highly suspected cases of dengue infection clinical management should not rely on negative serological results. (author)

  18. FREQUÊNCIA DOS CASOS DE DENGUE NOS DISTRITOS DO MUNICÍPIO DE DUQUE DE CAXIAS, RIO DE JANEIRO, BRASIL

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    Karla PEDRO

    2016-06-01

    Full Text Available Dengue, zika e chikungunya são doenças transmitidas por vetores, cujo detectar os criadouros dos mosquitos torna-se vital para medidas de controle. O objetivo desse estudo foi avaliar os casos notificados de dengue no município de Duque de Caxias (Rio de Janeiro, Brasil em seus quatro Distritos Sanitários, durante oito anos, compreendendo o período de 2007 a 2014. Essa região apresenta inúmeros problemas relacionados a processo de ocupação desordenada, densidade demográfica e altos índices de violência urbana e o município é organizado em quatro distritos. Os casos de dengue notificados à Secretaria Municipal de Saúde de Duque de Caxias e registrados na base municipal do SINAN (Sistema Nacional de Agravos de Notificação, referentes ao período de 2007 a 2014 foram utilizados neste estudo. Em 2008, 2011 e 2013, observou-se uma epidemia no município, que em 2008 tomou magnitude ainda maior e alcançou incidência de mais de mil casos a cada 100 mil habitantes. No período de 2009 e 2014, houve uma queda das incidências observadas, caracterizando-o como interepidêmico. Em relação aos casos de dengue em cada distrito, o primeiro e segundo distritos foram os que tiveram maior número de casos da doença, enquanto o quarto distrito foi o que teve menor número de casos em todos os anos estudados. Possivelmente, pelo fato do 1º distrito (Centro ter a maior parte das habitações e o 2º distrito (Campos Elíseos, abrigar as indústrias. Enquanto o 3º distrito (Imbariê e 4º distrito (Xerém são considerados muito mais arborizados e com poucos núcleos habitacionais.

  19. RECURRENT NOVAE IN M31

    Energy Technology Data Exchange (ETDEWEB)

    Shafter, A. W. [Department of Astronomy, San Diego State University, San Diego, CA 92182 (United States); Henze, M. [European Space Astronomy Centre, P.O. Box 78, E-28692 Villanueva de la Cañada, Madrid (Spain); Rector, T. A. [Department of Physics and Astronomy, University of Alaska Anchorage, 3211 Providence Dr., Anchorage, AK 99508 (United States); Schweizer, F. [Carnegie Observatories, 813 Santa Barbara St., Pasadena, CA 91101 (United States); Hornoch, K. [Astronomical Institute, Academy of Sciences, CZ-251 65 Ondřejov (Czech Republic); Orio, M. [Astronomical Observatory of Padova (INAF), I-35122 Padova (Italy); Pietsch, W. [Max Planck Institute for Extraterrestrial Physics, P.O. Box 1312, Giessenbachstr., D-85741, Garching (Germany); Darnley, M. J.; Williams, S. C.; Bode, M. F. [Astrophysics Research Institute, Liverpool John Moores University, Liverpool L3 5RF (United Kingdom); Bryan, J., E-mail: aws@nova.sdsu.edu [McDonald Observatory, Austin, TX 78712 (United States)

    2015-02-01

    The reported positions of 964 suspected nova eruptions in M31 recorded through the end of calendar year 2013 have been compared in order to identify recurrent nova (RN) candidates. To pass the initial screen and qualify as a RN candidate, two or more eruptions were required to be coincident within 0.′1, although this criterion was relaxed to 0.′15 for novae discovered on early photographic patrols. A total of 118 eruptions from 51 potential RN systems satisfied the screening criterion. To determine what fraction of these novae are indeed recurrent, the original plates and published images of the relevant eruptions have been carefully compared. This procedure has resulted in the elimination of 27 of the 51 progenitor candidates (61 eruptions) from further consideration as RNe, with another 8 systems (17 eruptions) deemed unlikely to be recurrent. Of the remaining 16 systems, 12 candidates (32 eruptions) were judged to be RNe, with an additional 4 systems (8 eruptions) being possibly recurrent. It is estimated that ∼4% of the nova eruptions seen in M31 over the past century are associated with RNe. A Monte Carlo analysis shows that the discovery efficiency for RNe may be as low as 10% that for novae in general, suggesting that as many as one in three nova eruptions observed in M31 arise from progenitor systems having recurrence times ≲100 yr. For plausible system parameters, it appears unlikely that RNe can provide a significant channel for the production of Type Ia supernovae.

  20. Nova-driven winds in globular clusters

    International Nuclear Information System (INIS)

    Scott, E.H.; Durisen, R.H.

    1978-01-01

    Recent sensitive searches for Hα emission from ionized intracluster gas in globular clusters have set upper limits that conflict with theoretical predictions. We suggest that nova outbursts heat the gas, producing winds that resolve this discrepancy. The incidence of novae in globular clusters, the conversion of kinetic energy of the nova shell to thermal energy of the intracluster gas, and the characteristics of the resultant winds are discussed. Calculated emission from the nova-driven models does not conflict with any observations to date. Some suggestions are made concerning the most promising approaches for future detection of intracluster gas on the basis of these models. The possible relationship of nova-driven winds of globular cluster X-ray sources is also considered

  1. Entre o limite e a esperança: relato de uma experiência em psicologia institucional

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    Patricia Gula

    Full Text Available O presente artigo propõe uma reflexão sobre o trabalho em Psicologia institucional. Utilizando-se da perspectiva teórica de Bleger, é apresentada uma experiência de trabalho desenvolvida em uma instituição localizada na cidade de Nova Friburgo, Estado do Rio de Janeiro, cujo principal propósito é profissionalizar adolescentes visando a seu ingresso no mercado de trabalho local. Como conclusão, são destacadas a importância e a pertinência do trabalho da Psicologia institucional, o qual permite uma significativa transformação tanto subjetiva, ao possibilitar, aos atores institucionais, a construção de suas próprias vidas, quanto institucional, ao tornar sua dinâmica mais flexível e menos cristalizada no exercício de um poder autoritário.

  2. Epidemia de dengue em Ipupiara e Prado, Bahia. Inquérito soro-epidemiológico Outbreak of dengue in Ipupiara and Prado, Bahia State. Seroepidemiologic survey

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    Pedro Fernando da Costa Vasconcelos

    2000-02-01

    Full Text Available No Brasil, os inquéritos sorológicos têm assinalado taxa de infecção pelo vírus do dengue de 25% a 56%, porém esses estudos foram realizados em populações de cidades de médio ou grande porte. No presente estudo, são descritas duas epidemias de febre clássica de dengue (DEN no Estado da Bahia. A primeira, ocorrida em 1987 e causada pelo sorotipo DEN-1 em Ipupiara e, a segunda, causada pelo DEN-2, em Prado e que ocorreu em 1995. O diagnóstico laboratorial foi realizado utilizando o teste de inibição da hemaglutinação (IH. Em 1995, foram coletadas 461 amostras sorológicas de uma população de 3.868 habitantes em Ipupiara (região da Chapada Diamantina e 228 de um total de 9.126 habitantes em Prado (Litoral Extremo Sul. A soro-positividade das amostras foi de 11,9% (55/461 em Ipupiara e 17,5% (40/228 em Prado. Não houve diferença, estatisticamente significante, quanto a idade e o gênero entre os indivíduos soro-positivos e negativos das duas cidades estudadas. Entretanto, em Ipupiara os soro-positivos (15,9% vs. 9,3% relataram, mais freqüentemente (p Serologic studies in Brazil have indicated a 25% to 56% prevalence of dengue virus infections. However, these studies were carried out in populations of middle-sized and larger cities. The present study describes two epidemics of classic dengue fever in two small cities in the State of Bahia. The first occurred in 1987, in Ipupiara and was caused by dengue serotype-1 (DEN-1, the second occurred in 1995, in Prado and was caused by dengue serotype-2 (DEN-2. The laboratory diagnosis was made by the hemagglutination-inhibitation test. 461 serum samples were collected in 1995 in Ipupiara (district of Chapada Diamantina out of a population of 3,868 and 228 samples out of a total of 9,126 inhabitants of Prado (in the Southernmost coastal region. The seropositivity of the samples was 11.9% (55/461 in Ipupiara and 17.5% (40/228 in Prado. These were no statistically significant differences

  3. Dengue fever: a Wikipedia clinical review.

    Science.gov (United States)

    Heilman, James M; De Wolff, Jacob; Beards, Graham M; Basden, Brian J

    2014-01-01

    Dengue fever, also known as breakbone fever, is a mosquito-borne infectious tropical disease caused by the dengue virus. Symptoms include fever, headache, muscle and joint pains, and a characteristic skin rash that is similar to measles. In a small proportion of cases, the disease develops into life-threatening dengue hemorrhagic fever, which results in bleeding, thrombocytopenia, and leakage of blood plasma, or into dengue shock syndrome, in which dangerously low blood pressure occurs. Treatment of acute dengue fever is supportive, with either oral or intravenous rehydration for mild or moderate disease and use of intravenous fluids and blood transfusion for more severe cases. Along with attempts to eliminate the mosquito vector, work is ongoing to develop a vaccine and medications targeted directly at the virus.

  4. Dengue vaccines: Challenges, development, current status and prospects

    Directory of Open Access Journals (Sweden)

    A Ghosh

    2015-01-01

    Full Text Available Infection with dengue virus (DENV is the most rapidly spreading mosquito-borne viral disease in the world. The clinical spectrum of dengue, caused by any of the four serotypes of DENV, ranges from mild self-limiting dengue fever to severe dengue, in the form dengue hemorrhagic fever (DHF and dengue shock syndrome (DSS. Increased rates of hospitalization due to severe dengue, during outbreaks, result in massive economic losses and strained health services. In the absence of specific antiviral therapy, control of transmission of DENV by vector management is the sole method available for decreasing dengue-associated morbidity. Since vector control strategies alone have not been able to satisfactorily achieve reduction in viral transmission, the implementation of a safe, efficacious and cost-effective dengue vaccine as a supplementary measure is a high public health priority. However, the unique and complex immunopathology of dengue has complicated vaccine development. Dengue vaccines have also been challenged by critical issues like lack of animal models for the disease and absence of suitable markers of protective immunity. Although no licensed dengue vaccine is yet available, several vaccine candidates are under phases of development, including live attenuated virus vaccines, live chimeric virus vaccines, inactivated virus vaccines, subunit vaccines, DNA vaccines and viral-vectored vaccines. Although some vaccine candidates have progressed from animal trials to phase II and III in humans, a number of issues regarding implementation of dengue vaccine in countries like India still need to be addressed. Despite the current limitations, collaborative effects of regulatory bodies like World Health Organization with vaccine manufacturers and policy makers, to facilitate vaccine development and standardize field trials can make a safe and efficacious dengue vaccine a reality in near future.

  5. Challenges in dengue fever in the elderly: atypical presentation and risk of severe dengue and hospital-acquired infection [corrected].

    Directory of Open Access Journals (Sweden)

    Emily K Rowe

    2014-04-01

    Full Text Available BACKGROUND/METHODS: To better understand dengue fever in the elderly, we compared clinical features, World Health Organization (WHO dengue classification and outcomes between adult (<60 and elderly (≥60 dengue patients. We explored the impact of co-morbidity and hospital-acquired infection (HAI on clinical outcomes in the elderly. All patients managed at the Communicable Disease Centre, Singapore, between 2005 and 2008 with positive dengue polymerase chain reaction (PCR or who fulfilled WHO 1997 or 2009 probable dengue criteria with positive dengue IgM were included. RESULTS: Of the 6989 cases, 295 (4.4% were elderly. PCR was positive in 29%. The elderly suffered more severe disease with more dengue haemorrhagic fever (DHF (29.2% vs. 21.4% and severe dengue (SD (20.3% vs. 14.6% (p<0.05. Classic dengue symptoms were more common in the adult group. The elderly were less likely to fulfill WHO 1997 (93.6% vs. 96.4% (p = 0.014, but not WHO 2009 probable dengue (75.3% vs. 71.5%. Time to dengue diagnosis was similar. There was no significant difference in the frequency of warning signs between the two groups, but the elderly were more likely to have hepatomegaly (p = 0.006 and malaise/lethargy (p = 0.033 while the adults had significantly more mucosal bleeding (p<0.001. Intensive care admission occurred in 15 and death in three, with no age difference. Notably, the elderly stayed in hospital longer (median 5 vs. 4 days, and suffered more pneumonia (3.8% vs. 0.7% and urinary infection (1.9% vs. 0.3% (p = 0.003. Predictors of excess length of stay were age (adjusted odds ratio [aOR] 2.01, 95% confidence interval [CI] 1.37-2.88, critical illness (aOR 5.13, 95%CI 2.59-9.75, HAI (aOR 12.06, 95%CI 7.39-19.9, Charlson score (aOR 6.9, 95%CI 2.02-22.56 and severe dengue (DHF/dengue shock syndrome/SD (aOR 2.24, 95%CI 1.83-2.74. CONCLUSION: Elderly dengue patients present atypically and are at higher risk of DHF, SD and HAI. Aside from dengue

  6. Cost of Dengue Vector Control Activities in Malaysia.

    Science.gov (United States)

    Packierisamy, P Raviwharmman; Ng, Chiu-Wan; Dahlui, Maznah; Inbaraj, Jonathan; Balan, Venugopalan K; Halasa, Yara A; Shepard, Donald S

    2015-11-01

    Dengue fever, an arbovirus disease transmitted by Aedes mosquitoes, has recently spread rapidly, especially in the tropical countries of the Americas and Asia-Pacific regions. It is endemic in Malaysia, with an annual average of 37,937 reported dengue cases from 2007 to 2012. This study measured the overall economic impact of dengue in Malaysia, and estimated the costs of dengue prevention. In 2010, Malaysia spent US$73.5 million or 0.03% of the country's GDP on its National Dengue Vector Control Program. This spending represented US$1,591 per reported dengue case and US$2.68 per capita population. Most (92.2%) of this spending occurred in districts, primarily for fogging. A previous paper estimated the annual cost of dengue illness in the country at US$102.2 million. Thus, the inclusion of preventive activities increases the substantial estimated cost of dengue to US$175.7 million, or 72% above illness costs alone. If innovative technologies for dengue vector control prove efficacious, and a dengue vaccine was introduced, substantial existing spending could be rechanneled to fund them. © The American Society of Tropical Medicine and Hygiene.

  7. Conhecimentos da população sobre dengue, seus vetores e medidas de controle em São José do Rio Preto, São Paulo The population's knowledge concerning dengue fever, vectors, and control measures in São José do Rio Preto, São Paulo state

    Directory of Open Access Journals (Sweden)

    Francisco Chiaravalloti Neto

    1997-09-01

    Full Text Available Desde 1985, vêm sendo realizadas, pelos órgãos de saúde, campanhas educativas institucionais para esclarecer a população sobre dengue, seus vetores e medidas de controle a serem adotadas. Para medir o nível de conhecimento da população de São José do Rio Preto, SP, aplicou-se, nos meses de abril e maio de 1995, um inquérito domiciliar em uma amostra de 537 residências da área urbana da cidade, entrevistando-se mesmo número de mulheres com perguntas sobre dengue, seus vetores e medidas de controle. Os conhecimentos demonstrados foram bastante satisfatórios, com exceção daqueles sobre a doença hemorrágica. Essa aquisição de conhecimentos, entretanto, não tem sido acompanhada da adoção das medidas de controle necessárias e não foi suficiente para a diminuição dos níveis de infestação dos vetores da dengue no município.Educational campaigns to inform the population about dengue fever, vectors, and related control measures have been carried out since 1985 by health services. In order to assess knowledge levels in São José do Rio Preto, São Paulo, a household survey was performed with a sample of 537 households in the urban area of São José do Rio Preto, São Paulo, in April and May 1995, where the same number of women were interviewed with questions about dengue fever, vectors, and control measures. Knowledge as displayed was satisfactory, except for that concerning hemorrhagic dengue. However, acquisition of knowledge was not followed by adoption of necessary control measures was insufficient to decrease infestation rates for dengue vectors in the city.

  8. Uma nova espécie de Hylodes Fitzinger da Serra da Mantiqueira, Minas Gerais, Brasil (Anura: Hylodidae A new species of Hylodes Fitzinger from Serra da Mantiqueira, State of Minas Gerais, Brazil (Anura: Hylodidae

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    Hélio R. da Silva

    2008-03-01

    Full Text Available Descrevemos uma nova espécie de Hylodes da Serra Negra, Município de Santa Bárbara do Monte Verde, Minas Gerais, sudeste do Brasil. A nova espécie pertence ao grupo Hylodes lateristrigatus, apresentando as seguintes características distintivas: corpo pequeno, focinho truncado em vistas dorsal e lateral, escudos da superfície dorsal dos discos dos dedos pouco desenvolvidos, superfície dorsal do corpo e coxas marrom-oliváceo com manchas escuras no dorso e listras nas patas traseiras. A nova espécie se distingue das demais do grupo pelo número de notas e características físicas do canto de anúncio e por vocalizar tanto de dia quanto à noite. Este é o primeiro registro de vocalização noturna para o gênero. Apresentamos descrições da vocalização e informações sobre a história natural da nova espécie. Discutimos a distribuição das espécies do gênero Hylodes, em relação às principais serras do leste do Brasil e seus sistemas de drenagem atuais.We describe a new species of Hylodes Fitzinger, 1826 from Serra Negra, Municipality of Santa Bárbara do Monte Verde, State of Minas Gerais, southeastern Brazil. The new species is a member of the Hylodes lateristrigatus group, characterized by the following combination of traits: small size, snout truncated in dorsal and in lateral views, upper surface of finger discs without well developed scutes, dorsum and dorsal portion of thigh light olive-brown with dark blotches, and dark stripes in the thighs. The new species is distinguishable from the other species of the group by details of the advertisement call, and because it's the first species registered for the genus that besides calling during the day, also calls at night. This is the first record of nocturnal call for the genus. Descriptions of vocalizations and information on natural history are provided. We also present a discussion on a possible patter of distribution of the genus relating to the highlands and today

  9. Le rôle des nouvelles technologies dans la construction des stratégies identitaires des jeunes des quartiers populaires d´Istanbul = O papel das novas tecnologias na construção de estratégias identitárias de jovens de jovens de bairros populares de Istambul

    Directory of Open Access Journals (Sweden)

    Ergur, Ali

    2009-01-01

    Full Text Available Este artigo analisa alguns aspectos da articulação de jovens em bairros populares de Istambul com o uso de novas tecnologias de informação e comunicação, como resultado de um projeto de pesquisa sobre três tipos diferentes de áreas urbanas periféricas. Nem um toque mágico, nem uma privação total baseada em classe, a experiência tecnológica de jovens possui uma dualidade fundamental, que alcança uma divisão gigantesca entre aqueles que podem acessar individualmente as novas tecnologias e aqueles que não podem. Este é, de fato, uma das principais especificidades do processo de globalização, que provoca nos indivíduos um efeito centrífugo apontando tanto para direções positivas quanto negativas. Este fenômeno foi observado no caso dos jovens que usam mais ou menos tecnologia para superar seus próprios contextos sociais limitados e em parte opressores, quando eles vão do local diretamente ao global, exclusivamente devido ao uso intenso da Internet. Desta maneira, uma nova experiência urbana está surgindo por meio de um isolamento espacial compensado tecnologicamente, através do que chamamos de conexões de saltos transversais, embora alguns outros permanecem excluídos deste processo global

  10. Evaluation of laboratory tests for dengue diagnosis in clinical specimens from consecutive patients with suspected dengue in Belo Horizonte, Brazil.

    Science.gov (United States)

    Ferraz, Fernanda Oliveira; Bomfim, Maria Rosa Quaresma; Totola, Antônio Helvécio; Ávila, Thiago Vinícius; Cisalpino, Daniel; Pessanha, José Eduardo Marques; da Glória de Souza, Danielle; Teixeira Júnior, Antônio Lúcio; Nogueira, Maurício Lacerda; Bruna-Romero, Oscar; Teixeira, Mauro Martins

    2013-09-01

    Dengue is a widely spread arboviral disease in tropical and subtropical regions of the world. Dengue fever presents clinical characteristics similar to other febrile illness. Thus laboratory diagnosis is important for adequate management of the disease. The present study was designed to evaluate the diagnostic performance of real-time PCR and serological methods for dengue in a real epidemic context. Clinical data and blood samples were collected from consecutive patients with suspected dengue who attended a primary health care unit in Belo Horizonte, Brazil. Serologic methods and real-time PCR were performed in serum samples to confirm dengue diagnosis. Among the 181 consecutive patients enrolled in this study with suspected dengue, 146 were considered positive by serological criteria (positive NS1 ELISA and/or anti-dengue IgM ELISA) and 138 were positive by real-time PCR. Clinical criteria were not sufficient for distinguishing between dengue and non-dengue febrile illness. The PCR reaction was pre-optimized using samples from patients with known viral infection. It had similar sensitivity compared to NS1 ELISA (88% and 89%, respectively). We also evaluated three commercial lateral flow immunochromatographic tests for NS1 detection (BIOEASY, BIORAD and PANBIO). All three tests showed high sensitivity (94%, 91% and 81%, respectively) for dengue diagnosis. According to our results it can be suggested that lateral flow tests for NS1 detection are the most feasible methods for early diagnosis of dengue. Copyright © 2013 Elsevier B.V. All rights reserved.

  11. Leptohyphidae (Insecta, Ephemeroptera do estado do Amazonas, Brasil: novos registros, nova combinação, nova espécie e chave de identificação para estágios ninfais Leptohyphidae (Insecta, Ephemeroptera of Amazonas state, Brazil: new records, new combination, new species and identification key for nymphal stages

    Directory of Open Access Journals (Sweden)

    Enide Luciana Lima Belmont

    2012-09-01

    Full Text Available Leptohyphidae (Insecta, Ephemeroptera do Estado do Amazonas, Brasil: novos registros, nova combinação, nova espécie e chave de identificação para estágios ninfais. Os seguintes gêneros de Leptohyphidae ocorrem no estado do Amazonas: Amanahyphes Salles & Molineri, Leptohyphes Eaton, Tricorythodes Ulmer e Tricorythopsis Traver. A distribuição das espécies de Leptohyphidae no Estado do Amazonas é apresentada. Uma espécie nova, Tricorythodes yapekuna sp. nov., é descrita e pode ser diferenciada de outros Tricorythodes pelas (1 garras tarsais com um par de dentículos submarginais e sem dentículos marginais; (2 palpo maxilar biarticulado; (3 brânquia opercular uniformemente preta com exceção da margem apical; (4 fórmula branquial 2/3/3/3/2; e (5 margem lateral do abdome expandida nos segmentos III_VI. Uma combinação nova, Tricorythopsis rondoniensis (Dias, Cruz & Ferreira, 2009 comb. nov., é proposta e constitui o primeiro registro dessa espécie para o Estado do Amazonas. Uma chave dicotômica ilustrada para identificar ninfas de gêneros e espécies ocorrentes no Amazonas também é apresentada.Leptohyphidae (Insecta, Ephemeroptera of Amazonas state, Brazil: new records, new combination, new species and identification key for nymphal stages. The following genera of Leptohyphidae occur in the Amazonas state: Amanahyphes Salles & Molineri, Leptohyphes Eaton, Tricorythodes Ulmer and Tricorythopsis Traver. Distribution of Leptohyphidae species in Amazonas state is presented. A new species, Tricorythodes yapekuna sp. nov., is described and can be distinguished from other Tricorythodes by: (1 tarsal claws with pair of submarginal denticles and no marginal denticles; (2 bi-articulated maxillary palp; (3 opercular gill black except on apical margin; (4 gill formula 2/3/3/3/2; and (5 expanded lateral abdominal margin of segments III_VI. The new combination, Tricorythopsis rondoniensis (Dias, Cruz & Ferreira, 2009 comb. nov., is proposed

  12. Reemergence of Dengue in Southern Texas, 2013

    Science.gov (United States)

    Thomas, Dana L.; Santiago, Gilberto A.; Abeyta, Roman; Hinojosa, Steven; Torres-Velasquez, Brenda; Adam, Jessica K.; Evert, Nicole; Caraballo, Elba; Hunsperger, Elizabeth; Muñoz-Jordán, Jorge L.; Smith, Brian; Banicki, Alison; Tomashek, Kay M.; Gaul, Linda

    2016-01-01

    During a dengue epidemic in northern Mexico, enhanced surveillance identified 53 laboratory-positive cases in southern Texas; 26 (49%) patients acquired the infection locally, and 29 (55%) were hospitalized. Of 83 patient specimens that were initially IgM negative according to ELISA performed at a commercial laboratory, 14 (17%) were dengue virus positive by real-time reverse transcription PCR performed at the Centers for Disease Control and Prevention. Dengue virus types 1 and 3 were identified, and molecular phylogenetic analysis demonstrated close identity with viruses that had recently circulated in Mexico and Central America. Of 51 household members of 22 dengue case-patients who participated in household investigations, 6 (12%) had been recently infected with a dengue virus and reported no recent travel, suggesting intrahousehold transmission. One household member reported having a recent illness consistent with dengue. This outbreak reinforces emergence of dengue in southern Texas, particularly when incidence is high in northern Mexico. PMID:27191223

  13. Trends in clinical trials of dengue vaccine

    Directory of Open Access Journals (Sweden)

    Priya Marimuthu

    2016-01-01

    Full Text Available Dengue is one of the most important vector-borne disease and an increasing problem worldwide because of current globalization trends. Roughly, half the world′s population lives in dengue endemic countries, and nearly 100 million people are infected annually with dengue. India has the highest burden of the disease with 34% of the global cases. In the context of an expanding and potentially fatal infectious disease without effective prevention or specific treatment, the public health value of a protective vaccine is clear. There is no licensed dengue vaccine is available still, but several vaccines are under development. Keeping in view the rise in dengue prevalence globally, there is a need to increase clinical drug and vaccine research on dengue. This paper briefly reviews on the development and current status of dengue vaccine to provide information to policymakers, researchers, and public health experts to design and implement appropriate vaccine for prophylactic intervention.

  14. Estudo de novas formulações para regeneração óssea em defeitos de dimensão crítica

    OpenAIRE

    Palma, Paulo Jorge Rocha da

    2009-01-01

    Estudo de novas formulações para regeneração óssea em defeitos de dimensão crítica Paulo Jorge Rocha da Palma Coimbra 2009 Resumo: Regenerar o osso perdido ou reabsorvido, é uma das grandes preocupações e desafios do Médico Dentista, necessitando muitas vezes da aplicação de um Biomaterial que permita uma boa regeneração óssea e tecidular. Com o objectivo de promover modalidades biológicas que possam estimular a regeneração óssea, têm vindo a ser desenhadas várias e...

  15. Por uma filosofia do medicamento

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    Cléber Domingos Cunha da Silva

    2015-09-01

    Full Text Available ResumoMedicamento e pensamento, em que coincidem estes conceitos? A proposta do presente ensaio é demonstrar, sob uma perspectiva biopolítica, a existência de novos desafios para aqueles que lidam com a temática da farmaceuticalização na sociedade contemporânea. As análises realizadas demonstram que abordagens essencialmente tecnicistas são insuficientes para o confronto de questões como: os lucros exorbitantes obtidos com a comercialização de medicamentos, a relação desproporcional desses valores com o número de novas moléculas inovadoras e o difícil acesso aos poucos novos fármacos. A proposta de uma filosofia do medicamento, no campo da saúde coletiva, parece oportuna para a tomada de posicionamentos mais críticos e para o estabelecimento de espaços de resistência às condutas farmacoterapêuticas. Afinal, o medicamento não é um elemento isolado constitutivo da vida humana; embora, tenha se tornado um componente central no governo da vida contemporânea, o seu emprego adequado requer o exercício do pensamento.

  16. 80 anos do Manifesto dos Pioneiros da Educação Nova: questões para debate 80 years of the Manifesto of the Pioneers of Educação Nova: questions for the debate

    Directory of Open Access Journals (Sweden)

    Diana Gonçalves Vidal

    2013-01-01

    Full Text Available O artigo, produzido no âmbito das comemorações dos 80 anos de publicação do Manifesto dos Pioneiros da Educação Nova, interroga-se sobre a atualidade dessa carta. Para tanto, explora as condições históricas de emergência do documento, os significados atribuídos à Escola Nova no Brasil na década de 1930 e as contendas ocorridas na arena educacional no período. Além disso, discorre sobre as especificidades do movimento escolanovista brasileiro, procurando demonstrar que a Escola Nova constituiu-se no país como uma fórmula, com significados múltiplos e distintas apropriações produzidas no entrelaçamento de três vertentes: a pedagógica, a ideológica e a política. No que tange ao primeiro aspecto, a indefinição das fronteiras conceituais permitiu que a expressão Escola Nova aglutinasse diferentes educadores, católicos e liberais, em torno de princípios pedagógicos do ensino ativo. No segundo caso, a fórmula ofereceu-se como meio para a transformação da sociedade, servindo às finalidades divergentes dos grupos em litígio. Já na terceira acepção, tornou-se bandeira política, sendo capturada como signo de renovação do sistema educacional pelo Manifesto e por seus signatários. Assim, o documento emergiu como parte do jogo político pela disputa do controle do Estado e de suas dinâmicas, e, portanto, como elemento de coesão de uma frente de educadores que, a despeito de suas diferenças, articulava-se em torno de alguns objetivos comuns, como laicidade, gratuidade e obrigatoriedade da educação. Ademais, ele também foi representante de um grupo de intelectuais que abraçava um mesmo projeto de nação, ainda que com divergências internas.The article, prepared in the context of the celebrations marking the 80 years of the publication of the Manifesto of the Pioneers of Educação Nova, inquiries into the current value of this charter. For that, it explores the historical conditions of the emergence of this

  17. Dengue Fever: Causes, Complications, and Vaccine Strategies

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    Niyati Khetarpal

    2016-01-01

    Full Text Available Dengue is a highly endemic infectious disease of the tropical countries and is rapidly becoming a global burden. It is caused by any of the 4 serotypes of dengue virus and is transmitted within humans through female Aedes mosquitoes. Dengue disease varies from mild fever to severe conditions of dengue hemorrhagic fever and shock syndrome. Globalization, increased air travel, and unplanned urbanization have led to increase in the rate of infection and helped dengue to expand its geographic and demographic distribution. Dengue vaccine development has been a challenging task due to the existence of four antigenically distinct dengue virus serotypes, each capable of eliciting cross-reactive and disease-enhancing antibody response against the remaining three serotypes. Recently, Sanofi Pasteur’s chimeric live-attenuated dengue vaccine candidate has been approved in Mexico, Brazil, and Philippines for usage in adults between 9 and 45 years of age. The impact of its limited application to the public health system needs to be evaluated. Simultaneously, the restricted application of this vaccine candidate warrants continued efforts in developing a dengue vaccine candidate which is additionally efficacious for infants and naïve individuals. In this context, alternative strategies of developing a designed vaccine candidate which does not allow production of enhancing antibodies should be explored, as it may expand the umbrella of efficacy to include infants and naïve individuals.

  18. A nova divisão internacional do trabalho, capitalismo cognitivo e desenvolvimento na América Latina

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    Carlo Vercellone

    2016-12-01

    Full Text Available O artigo propõe revisar questões relacionadas ao desenvolvimento da América Latina em função das transformações inerentes à crise do capitalismo industrial e à transição a um ‘novo capitalismo’, categorizado como capitalismo cognitivo. Com este objetivo, a análise está dividida em três partes. Na primeira parte se propõe uma revisão da crise estrutural do paradigma da industrialização, legado das teorias do desenvolvimento formuladas entre os anos 1950-1980. A segunda parte aborda as dificuldades e desafios produzidos pela nova divisão internacional do trabalho, fundada sobre os princípios cognitivos e o fortalecimento dos direitos de propriedade intelectual. E, finalmente uma terceira parte na qual se busca identificar certas características de uma estratégia de desenvolvimento pós-industrial para os países latino-americanos.

  19. Synoptic GNIRS XD Spectra ToO Novae

    Science.gov (United States)

    Woodward, Chick; Helton, Andrew; Spitzer/Chandra Team

    2007-02-01

    Novae are important contributors to galactic chemical enrichment on local scales. NIR spectroscopy of novae provides information about the elemental abundances of the gas and dust in the ejecta dispersing into the ISM as well as kinematic information related to the outburst. We propose to obtain synoptic GNIRS spectra of select Target of Opportunity (ToO) novae in the Magellanic Clouds (MC) and the galaxy to study the dynamics of the ejecta, to determine the temporal evolution of coronal lines and recombination lines (measuring their strength and velocity profiles), and to determine abundances. Being all equidistant, MC nova permit a more robust analysis of distant-dependent physical parameters of outburst than is generally possible for Galactic novae. The GNIRS data will provide critical spectral coverage and synoptic data to complement extant Spitzer and Chandra nova programs. Triggering of the GNIRS program will occur when a nova becomes brighter than V=12 mag, (assuming that adequate PWFS guide stars exist) as reported in the IAUC or CBET.

  20. CLINICAL AND LABORATORY PROFILE OF DENGUE FEVER

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    Farhan Fazal

    2015-02-01

    Full Text Available AIM: Dengue is a major health problem in many parts of India and Gulbarga (North Karnataka was previously not a known endemic area f or dengue. Infection with dengue virus can cause a spectrum of three clinical syndromes , classic dengue fever (DF , dengue hemorrhagic fever (DHF and dengue shock syndrome (DSS. The present study was undertaken to determine the disease profile of dengue virus infection in hospitalized patients. METHODS AND MATERIAL: One hundred patients admitted in Basaveshwar Teaching and General hospital with fever more than 38.5 degree Celsius and IgM dengue positive were selected. They were followed from the onset of fever to twelve days or till they are recovered according to WHO discharge criteria whichever is earlier. They underwent relevant investigations to identify specific organ dysfunction and categorize them into the spectrum of Dengue fever in accordance to W HO criteria . RESULTS: Out of 100 cases in this study 70 cases belongs to DF , 23 cases to DHF and 7 cases to DSS based on WHO criteria. All the cases had fever (100%. Other common symptoms noted were myalgia (61% , joint pain (54% , headache (66% , vomitin g (55% , pain abdomen (48% , rash (41% , hepatomegaly (20% , bleeding (21% and shock (8%. Hess test was positive in 24% patients. Low platelet count of less than 100 , 000/cu mm according to WHO criteria was present in 73% patients. Deranged liver functio n test and renal parameters were seen in 26 and 8 patients respectively . Mortality documented was 7 patients due to delayed presentation. The average duration of hospital stay was 4.65 days. CONCLUSION: Dengue fever was a more common manifestation than DHF or DSS. During aepidemic , dengue should be strongly considered on the differential diagnosis of any patient with fever. The treatment of dengue is mainly fluid management and supportive. Early recognition and management of alarm symptoms is the key to bet ter outcome

  1. Uma nova noção de empresário: a naturalização do "empreendedor"

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    Elaine da Silveira Leite

    2008-11-01

    Full Text Available Atualmente notamos uma explosão de livros, revistas e programas de televisão voltados para temas como carreira, negócios e empreendedorismo. Enquanto há, de um lado, uma literatura acadêmica que estuda o empreendedorismo como um tipo de ação econômica e o empreendedor como um ator social a quem corresponde um tipo de prática ligada à liderança e à inovação, há também , de outro, uma literatura não acadêmica que faz do empreendedorismo um conjunto de princípios ideais de bom comportamento e que, a partir desse conjunto, estabelece prescrições normativas para aqueles que desejam tornar-se empreendedores. Diante disso, o presente artigo pretende discutir a construção de uma ideologia que traz, na noção de empreendedor, o empresário como um ator social imbuído de uma conotação ética. As histórias de sucesso de empresários aparecem como um rico material empírico para a compreensão da construção e da difusão de uma ideologia na qual a noção de empresário vai sendo ressignificada. No centro desse processo, encontram-se os "gurus" da administração, os quais, por meio de seus sucessos editoriais, da internet e da grande mídia, difundem uma série de conselhos práticos e assumem a função de empreendedores morais do empreendedorismo. Conclui-se que, por meio desses conselhos e da divulgação dos casos exemplares de sucesso (assim como foi com o protestantismo, no início do capitalismo, formam-se sujeitos com disposição para atuar economicamente e de forma reconhecida como boa e justa. O empreendedorismo pode, portanto, sob esse ponto de vista, ser visto como uma ideologia do capitalismo atual que surge para garantir a adesão e a legitimidade a atividades antes não valorizadas.

  2. Abastecimento irregular de água, seu uso domiciliar e dengue: uma pesquisa biossocial no Nordeste do Brasil

    OpenAIRE

    Caprara, Andrea; Lima, José Wellington de Oliveira; Marinho, Alice Correia Pequeno; Calvasina, Paola Gondim; Landim, Lucyla Paes; Sommerfeld, Johannes

    2009-01-01

    Despite increased vector control efforts, dengue fever remains endemic in Fortaleza, Northeast Brazil, where sporadic epidemic outbreaks have occurred since 1986. Multiple factors affect vector ecology such as social policy, migration, urbanization, city water supply, garbage disposal and housing conditions, as well as community level understanding of the disease and related practices. This descriptive study used a multi-disciplinary approach that bridged anthropology and entomology. A multip...

  3. Estudo sobre o diagnóstico laboratorial e sintomas do dengue, durante epidemia ocorrida na região de Ribeirão Preto, SP, Brasil Laboratory diagnosis and symptoms of dengue studied during an outbreak in the Ribeirao Preto Region, SP, Brazil

    Directory of Open Access Journals (Sweden)

    Luiz Tadeu Moraes Figueiredo

    1992-04-01

    Full Text Available Uma epidemia de dengue tipo 1 se iniciou em Novembro de 1990 na Região de Ribeirão Preto, Norte do Estado de São Paulo. Foram confirmados por exames laboratoriais cerca de 3.500 casos até fevereiro de 1991. A Unidade de Pesquisa em Virologia da Faculdade de Medicina de Ribeirão Preto - USP, estudou soros de 502 pessoas suspeitas de apresentarem dengue. Fez-se o diagnóstico sorológico através do método da inibição da hemaglutinação (HAI para dengue tipo 1 em 19% dos analisados. Passou-se a utlilizar um teste imuno-enzimático para dengue em culturas celulares infectadas (EIA-ICC, que permite identificação simultânea de IgG e IgM. O EIA-ICC embora menos sensível quando comparado ao HAI (89%, mostrou-se mais eficiente, porque: dispensou a obtenção de segundas amostras séricas para o diagnóstico; trata-se de técnica simples, podendo ser efetuada em apenas 5 horas. O vírus dengue tipo 1 foi isolado do sangue de 21 pacientes, por inoculação em células de mosquitos C6/36. Fez-se a identificação dos vírus isolados por método de imunofluorescência indireta, utilizando anti-soro contra todos os flavivirus e anticorpos monoclonais tipo-específicos de dengue. Os sintomas mais freqüentemente observados em 71 indivíduos com diagnóstico de dengue confirmado foram febre (90% dos casos, mialgias (57% e artralgias (41%A dengue type 1 outbreak started in the Ribeirao Preto Region, North of Sao Paulo State, Brazil, in November of 1990. About 3500 dengue cases were confirmed by blood tests until February of 1991. The Virus Research Unit of The Faculty of Medicine of Ribeirao Preto - Sao Paulo State University, studied 502 dengue suspect cases. The Serologic diagnosis of dengue type 1 was confirmed by haemmaglutination inhibition test (HAI in 19% of the cases. Diagnosis was done later by using an enzyme immuno assay on infected cultured cells (EIA-ICC which discriminated IgG and IgM dengue, antibodies. EIA-ICC was less sensitive (89

  4. A Obra Cinematográfica como Formadora de Sentidos: uma análise do filme Memórias de uma Gueixa

    OpenAIRE

    Maria Perufo, Dangela; Cavalli, Vanessa

    2010-01-01

    O estudo tem como objetivo verificar o papel da Direção de Arte como formadora de sentidos em imagens e sons, dentro do conjunto da produção cinematográfica, analisando dois aspectos: figurino e fotografia, no filme Memórias de uma Gueixa, dirigido por Rob Marshall. Inicia-se o texto tratando de referenciais teóricos que fundamentam a pesquisa, conceituando tópicos como nova linguagem oral, cultura, adaptação de literatura para vídeo, linguagem verbal e não verbal. O artigo também trata de de...

  5. Clinico-laboratory spectrum of dengue viral infection and risk factors associated with dengue hemorrhagic fever: a retrospective study

    OpenAIRE

    Mallhi, Tauqeer Hussain; Khan, Amer Hayat; Adnan, Azreen Syazril; Sarriff, Azmi; Khan, Yusra Habib; Jummaat, Fauziah

    2015-01-01

    Background The incidence of dengue is rising steadily in Malaysia since the first major outbreak in 1973. Despite aggressive measures taken by the relevant authorities, Malaysia is still facing worsening dengue crisis over the past few years. There is an urgent need to evaluate dengue cases for better understanding of clinic-laboratory spectrum in order to combat this disease. Methods A retrospective analysis of dengue patients admitted to a tertiary care teaching hospital during the period o...

  6. Distrofia miotônica: análise clínico-genética de uma família

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    Jeová Barros da Silva

    1970-03-01

    Full Text Available Mediante o estudo de um caso probando foi possível fazer levantamento genealógico de uma família com 12 membros de ambos os sexos, afetados por distrofia miotônica. São analisados aspectos clínicos e laboratoriais, muitos dos quais confirmam trabalhos publicados anteriormente. Algumas novas contribuições são feitas uma vez que alguns dados são discrepantes dos já anteriormente registrados. A hereditariedade desta anomalia caracteriza-se por transmissão de um fator dominante e autossômico.

  7. Chapecó (SC), para além de polo regional, uma cidade média no oeste catarinense

    OpenAIRE

    Cristiane Gretzler

    2011-01-01

    Uma das primeiras cidades criadas no impulso colonizador do Oeste Catarinense, Chapecó, durante vários anos foi à sede administrativa de vasto território, situação que conferiu à cidade uma centralidade que se manifesta ainda hoje. O processo de urbanização brasileira provocou mudanças na estrutura das diferentes cidades, independente de seu porte, suscitando novas análises e interpretações. As metrópoles assumiram novos papéis em escala mundial e, muitas cidades polo regionais, acabam criand...

  8. Social justice, climate change, and dengue.

    Science.gov (United States)

    Chang, Aileen Y; Fuller, Douglas O; Carrasquillo, Olveen; Beier, John C

    2014-06-14

    Climate change should be viewed fundamentally as an issue of global justice. Understanding the complex interplay of climatic and socioeconomic trends is imperative to protect human health and lessen the burden of diseases such as dengue fever. Dengue fever is rapidly expanding globally. Temperature, rainfall, and frequency of natural disasters, as well as non-climatic trends involving population growth and migration, urbanization, and international trade and travel, are expected to increase the prevalence of mosquito breeding sites, mosquito survival, the speed of mosquito reproduction, the speed of viral incubation, the distribution of dengue virus and its vectors, human migration patterns towards urban areas, and displacement after natural disasters. The burden of dengue disproportionately affects the poor due to increased environmental risk and decreased health care. Mobilization of social institutions is needed to improve the structural inequalities of poverty that predispose the poor to increased dengue fever infection and worse outcomes. This paper reviews the link between dengue and climatic factors as a starting point to developing a comprehensive understanding of how climate change affects dengue risk and how institutions can address the issues of social justice and dengue outbreaks that increasingly affect vulnerable urban populations. Copyright © 2014 Chang, Fuller, Carrasquillo, Beier. This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original author and source are credited.

  9. Metformin Use and Severe Dengue in Diabetic Adults.

    Science.gov (United States)

    Htun, Htet Lin; Yeo, Tsin Wen; Tam, Clarence C; Pang, Junxiong; Leo, Yee Sin; Lye, David C

    2018-02-20

    Diabetes mellitus is a risk factor for severe dengue in adults, but few studies have examined the association between metformin use and disease severity in dengue. In addition to its effect on glucose control, metformin has been associated with pleiotropic properties in preclinical studies. Using a cohort of laboratory-confirmed adult (≥21 years) dengue patients with diabetes mellitus admitted to Tan Tock Seng Hospital, we conducted a retrospective cohort study involving 131 (58.7%) metformin users and 92 (41.3%) non-users. Dengue severity was categorized as dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS) in World Health Organization (WHO) 1997 criteria and severe dengue (SD) in WHO 2009 criteria. Multivariable Poisson regression with robust error variance was used to estimate risk ratio (RR). Compared with non-use, metformin use was associated with a decreased risk of developing severe dengue (adjusted risk ratio [aRR] = 0.60, 95% confidence interval [CI]: 0.37-0.98, P = 0.04). Additionally, there was an inverse dose-response relationship (aRR = 0.69, 95% CI: 0.49-0.98, P = 0.04) with dengue severity as classified by WHO 2009 criteria. Use of metformin, however, was not associated with dengue severity based on WHO 1997 criteria; and no dose-response relationship was noted. Our results suggest metformin use could attenuate disease severity in dengue-infected diabetes mellitus individuals.

  10. GESTÃO NÃO PROFISSIONAL DE UMA COOPERATIVA DE CRÉDITO MÚTUO E SUAS CONSEQUÊNCIAS: UM ESTUDO SOB A ÓTICA DA TEORIA DA NOVA ECONOMIA INSTITUCIONAL / MANAGEMENT NOT PROFESSIONAL OF AN MUTUAL CREDIT COOPERATIVE AND ITS CONSEQUENCES

    OpenAIRE

    Freire, Adriano Higino; Universidade Federal de Lavras; Medeiros, André Luiz; Universidade Federal de Itajubá; Andrade, Diego César Terra de; Instituto Federal de Educação, Ciência e Tecnologia do Sul de Minas Gerais; Santos, Antônio Carlos dos; Universidade Federal de Lavras

    2014-01-01

    Este trabalho tem por objetivo verificar a influência dos conceitos de custos de transação e de agência da Nova Economia Institucional, baseando-se nos indicadores técnicos e financeiros que levaram uma cooperativa de crédito, aqui denominada CRED, a implantar um plano gerencial de reestruturação. Empregou-se a metodologia do estudo de caso, tendo como técnicas de pesquisa a utilização de documentação, dados arquivados, além da observação participante. Após trabalhos de inspeção do Banco Cent...

  11. PATHOGENESIS OF HEMORRHAGIC DUE TO DENGUE VIRUS

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    Arief Suseno

    2015-01-01

    Full Text Available Dengue is a viral disease that is mediated by a mosquito, which causes morbidity and mortality. Viruses can increase vascular permeability which can lead to hemorrhagic diathesis or disseminated intravascular coagulation (DIC known as dengue hemorrhagic fever (DHF. In Indonesia, dengue hemorrhagic fever (DHF are caused by dengue virus infection which was found to be endemic accompanied by an explosion of extraordinary events that appear at various specified period. The diagnosis of dengue is determined based on the criteria of the World Health Organization (WHO, 1999, which are sudden high fever accompanied by a marked tendency to hemorrhage positive tourniquet test, petechiae, ecchymosis, purpura, mucosal hemorrhagic, hematemesis or melena and thrombocytopenia. The problem that still exists today is the mechanism of thrombocytopenia in patients with varying degrees of dengue involving levels of vWF (von Willebrand factor and prostaglandin I2 (PGI2 can not be explained. The mechanism of hemorrhagic in dengue virus infections acquired as a result of thrombocytopenia, platelet disfunction decreased coagulation factors, vasculopathy with endothelial injury and disseminated intravascular coagulation (DIC.

  12. A PATIENT DENGUE HEMORRHAGIC FEVER WITH SPASMS

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    Ulfa Kholili

    2014-09-01

    Full Text Available Indonesia is one of the countries with the high endemic of Dengue viral infection followed by Thailand, Myanmar, India and Srilanka. For more 10-15 years, Dengue Viral Infection/DHF has become a cause of patient who should be hospitalized and was the first cause of death children in south easthern Asia.1,2 Batavia was the first city of Indonesia found Dengue Viral infection which had been written in journal by David Bylon in the 1779. Encephalopathy of dengue (ED is one unusually complication of dengue viral infection which had been characterized by aberration the arrangement of nerves central (CNS. This paper want to describe of a young teenage with suffer from DHF and seizure. Beside it, pleural effusion and cerebral edema had been found. Seizure most likely due to dengue encephalopathy associated with cerebral edema and was supported by positive IgG and IgM anti dengue. Corticosteroid was given to improve cerebral edema. By good management as long as admission, she was discharged from hospital with a good condition.

  13. Indicadores socioambientais para vigilância da dengue em nível local Socio-environmental indicators for dengue surveillance in the local level

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    Regina Fernandes Flauzino

    2011-03-01

    Full Text Available Este artigo caracteriza uma localidade quanto às condições de saneamento e processos de degradação ambiental que possam estar relacionados à transmissão da dengue, além de discutir a construção de novos indicadores socioambientais visando à vigilância epidemiológica. A área de estudo foi a Ilha da Conceição, no município de Niterói, RJ. Informantes-chave foram entrevistados para obter informações que pudessem ser utilizadas nas construções de novos indicadores. Ao se compararem os dados do IBGE com os fornecidos pelos informantes, foram encontradas algumas diferenças. Os dados dos informantes são mais condizentes com a realidade local, propiciando, de acordo com a área, a observação de diferentes modus operandi de coleta de lixo e limpeza pública. Os casos concentraram-se nos setores favela plana e favela morro. Concluiu-se que os indicadores referentes à frequência de abastecimento de água e coleta de lixo se mostram importantes para serem analisados em estudos de nível local associados com a incidência da dengue.This paper characterizes a local area in terms of sanitary conditions and environmental degradation processes that may be related to dengue transmission, and discusses the construction of new social and environmental indicators aiming at epidemiological surveillance. The studied area was Ilha da Conceição, in the municipality of Niterói, state of Rio de Janeiro. Key informants were interviewed to obtain information that could be used in the construction of new indicators. Comparing the data from the IBGE with those provided by the informants, we found some differences. The data provided by the latter are more reliable regarding the local reality, and they enable, according to the area, the observation of different modus operandi of garbage collection and public cleansing. The cases were concentrated on flat slum and hill slum areas. It was concluded that it is important to analyze indicators

  14. Transmission spectroscopy of dengue viral infection

    International Nuclear Information System (INIS)

    Firdous, S; Ahmed, M; Rehman, A; Nawaz, M; Anwar, S; Murtaza, S

    2012-01-01

    We presented the rapid diagnostic test for dengue infection based on light spectrum of human blood. The transmission spectra of dengue infected whole blood samples have been recorded in ultra violet to near infrared range (400 – 800 nm) of about 30 conformed infected patients and compared to normal blood samples. Transmission spectra of dengue infected blood illustrate a strong band from 400 – 600 nm with prominant peaks at 540 and 580 nm, where is in case of normal blood below 600 nm, total absorption has been observed. These prominent peaks from 400 – 600 nm are characteristics of cells damage and dangue virus antibodies immunoglobulin G (IgG) and immunoglobulin M (IgM) produced against dengue antigen. The presented diagnostic method is non invasive, cost effective, easy and fast screening technique for dengue infected patients

  15. Epidemic dengue and dengue hemorrhagic fever at the Texas-Mexico border: results of a household-based seroepidemiologic survey, December 2005.

    Science.gov (United States)

    Ramos, Mary M; Mohammed, Hamish; Zielinski-Gutierrez, Emily; Hayden, Mary H; Lopez, Jose Luis Robles; Fournier, Marta; Trujillo, Alfredo Rodríguez; Burton, Roy; Brunkard, Joan M; Anaya-Lopez, Luis; Banicki, Allison Abell; Morales, Pablo Kuri; Smith, Brian; Muñoz, Jorge L; Waterman, Stephen H

    2008-03-01

    A dengue-2 epidemic causing dengue hemorrhagic fever (DHF) occurred in the contiguous border cities of Matamoros, Tamaulipas (Mexico), and Brownsville, TX, in 2005. In December, we conducted a household-based epidemiologic survey to determine the incidence and seroprevalence of dengue infection among Matamoros and Brownsville residents and to identify risk factors associated with infection. Antibodies to dengue were measured in 273 individuals. The estimated incidence of recent dengue infection was 32% and 4% among Matamoros and Brownsville participants, respectively. The estimated prevalence of past dengue infection was 77% and 39% among Matamoros and Brownsville participants, respectively. The Breteau index was 28 in Matamoros and 16 in Brownsville, reflecting an abundant winter population of Aedes mosquitoes. Discarded waste tires and buckets were the two largest categories of infested containers found in both cities. Our results underscore the risk for epidemic dengue and DHF in the Texas-Mexico border region.

  16. Inner Disk Structure of Dwarf Novae in the Light of X-Ray Observations

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    S. Balman

    2015-02-01

    Full Text Available Diversity of the X-ray observations of dwarf nova are still not fully understood. I review the X-ray spectral characteristics of dwarf novae during the quiescence in general explained by cooling flow models and the outburst spectra that show hard X-ray emission dominantly with few sources that reveal soft X-ray/EUV blackbody emission. The nature of aperiodic time variability of brightness of dwarf novae shows band limited noise, which can be adequately described in the framework of the model of propagating fluctuations. The frequency of the break (1-6 mHz indicates inner disk truncation of the optically thick disk with a range of radii (3.0-10.0×109 cm. The RXTE and optical (RTT150 data of SS Cyg in outburst and quiescence reveal that the inner disk radius moves towards the white dwarf and receeds as the outburst declines to quiescence. A preliminary analysis of SU UMa indicates a similar behaviour. In addition, I find that the outburst spectra of WZ Sge shows two component spectrum of only hard X-ray emission, one of which may be fitted with a power law suggesting thermal Comptonization occuring in the system. Cross-correlations between the simultaneous UV and X-ray light curves (XMM −Newton of five DNe in quiescence show time lags in the X-rays of 96-181 sec consistent with travel time of matter from a truncated inner disk to the white dwarf surface. All this suggests that dwarf novae and other plausible nonmagnetic systems have truncated accretion disks indicating that the disks may be partially evaporated and the accretion may occur through hot (coronal flows in the disk.

  17. Mediational effects of self-efficacy dimensions in the relationship between knowledge of dengue and dengue preventive behaviour with respect to control of dengue outbreaks: a structural equation model of a cross-sectional survey.

    Directory of Open Access Journals (Sweden)

    Affendi Isa

    Full Text Available Dengue fever is endemic in Malaysia, with frequent major outbreaks in urban areas. The major control strategy relies on health promotional campaigns aimed at encouraging people to reduce mosquito breeding sites close to people's homes. However, such campaigns have not always been 100% effective. The concept of self-efficacy is an area of increasing research interest in understanding how health promotion can be most effective. This paper reports on a study of the impact of self-efficacy on dengue knowledge and dengue preventive behaviour.We recruited 280 adults from 27 post-outbreak villages in the state of Terengganu, east coast of Malaysia. Measures of health promotion and educational intervention activities and types of communication during outbreak, level of dengue knowledge, level and strength of self-efficacy and dengue preventive behaviour were obtained via face-to-face interviews and questionnaires. A structural equation model was tested and fitted the data well (χ(2 = 71.659, df = 40, p = 0.002, RMSEA = 0.053, CFI = 0.973, TLI = 0.963. Mass media, local contact and direct information-giving sessions significantly predicted level of knowledge of dengue. Level and strength of self-efficacy fully mediated the relationship between knowledge of dengue and dengue preventive behaviours. Strength of self-efficacy acted as partial mediator in the relationship between knowledge of dengue and dengue preventive behaviours.To control and prevent dengue outbreaks by behavioural measures, health promotion and educational interventions during outbreaks should now focus on those approaches that are most likely to increase the level and strength of self-efficacy.

  18. O trabalho dos operadores de máquinas colhedoras de cana-de-açúcar : uma abordagem ergonômica

    OpenAIRE

    Lidiane Regina Narimoto

    2012-01-01

    O Brasil é o maior produtor de cana-de-açúcar do mundo, fazendo do setor sucroalcooleiro uma das atividades agrícolas mais importantes do país. Nos últimos anos, a mecanização do corte de cana-de-açúcar tem sido encarada como uma importante ferramenta para a expansão da produção e atendimento da demanda mundial. Com a mecanização, surgem diversas novas ocupações, dentre elas a operação de máquinas colhedoras, que ocupa papel central em todo o processo. Entretanto, existe uma carência de estud...

  19. Design e construção de nova interface para a BVS Psicologia (BVS-PSI Brasil e a experiência de criação do protótipo da BVS ULAPSI: facilitando a vida de usuários

    Directory of Open Access Journals (Sweden)

    Antonio Marcos Amorim

    2006-01-01

    Full Text Available Relata-se a experiência de atualização da BVS Psicologia Brasil (http://www.bvs-psi.org.br/ e criação do protótipo da BVS ULAPSI (Biblioteca Virtual da União de Entidades Latino-Americanas de Psicologia, ocorrida em 2005, pela Biblioteca do Instituto de Psicologia da USP (SBD/IPUSP como unidade gerenciadora, em parceria com a BIREME e o Fórum das Entidades Brasileiras de Psicologia. Discutiu-se o processo de adoção de ferramentas tecnológicas e outros aspectos relacionados sempre que uma Unidade de Informação intente tal empreitada. As novas tecnologias sejam da metodologia BIREME ou softwares proprietários permitiram maior flexibilidade na inclusão de novas fontes de informação. Os profissionais técnicos e os administradores devem realizar um trabalho cooperativo na tomada de decisões, considerando a rápida introdução de novas interfaces. Assim são evitados problemas no uso de ferramentas em uma assimilação e manutenção pela equipe responsável. Em curto prazo, os profissionais devem prever as dificuldades, pois é quando ocorre o lançamento de uma biblioteca virtual.

  20. Mudança estratégica e processo de institucionalização em uma universidade: o desenvolvimento de esquemas interpretativos entre os gestores

    Directory of Open Access Journals (Sweden)

    Fernando Colares Palacios

    2014-11-01

    Full Text Available http://dx.doi.org/10.5007/1983-4535.2014v7n3p206 O objetivo da pesquisa foi identificar e analisar ideias, valores e crenças presentes nos processos cognitivos dos gestores de uma nova unidade universitária em processo de implantação de uma nova estratégia. A partir de questionamentos sobre as dimensões da mudança propostas por Mintzberg et al. (2006, é avaliado o desenvolvimento de esquemas interpretativos capazes de comprovar ou não o início de um processo de institucionalização. A coleta de dados deu-se por meio de entrevistas semi-estruturadas com os gestores de nível médio, observação não participante e análise documental. A pesquisa caracteriza-se como um estudo de caso, com perspectiva de análise transversal e abordagem descritivo-qualitativa, sendo o foco, o processo de mudança estratégica em uma universidade pública brasileira Os resultados evidenciaram a importância da análise dos esquemas interpretativos dos dirigentes para compreender o nível de institucionalização de dado projeto. Também se constataram práticas incongruentes com o projeto da nova unidade e que podem comprometer a efetiva implementação da estratégia formulada.

  1. Testando as previsões da Pecking Order Theory no financiamento das empress brasileiras: uma nova metodologia.

    Directory of Open Access Journals (Sweden)

    Marina da Silva Borges de Araújo

    2008-06-01

    Full Text Available Considerando a existência de assimetria de informação entre gestores e investidores, Myers (1984 afirma que a formação da estrutura de capital por parte das empresas está baseada em uma hierarquia de captação conhecida como Pecking Order Theory (POT, favorecendo seqüencialmente a utilização de recursos internos, emissão de dívida e, por último, emissão de ações. A verificação empírica esbarra em questões metodológicas, sendo a POT por vezes confirmada e outras negada. Neste artigo, propõe-se uma metodologia diferente, reconhecendo as características das empresas como tamanho, lucratividade e crescimento, para explicar o financiamento do déficit, utilizando um modelo de dados em painel. Analisou-se uma amostra de 313 empresas listadas na Bovespa de 2000 a 2005. Os resultados indicam que unicamente as empresas de menor tamanho na amostra, de lucratividade negativa e baixo crescimento, apresentam aderência (fraca às previsões da POT. Assim, essa teoria não pode ser considerada uma teoria geral para explicar a estrutura de capital das empresas.

  2. Penentuan Serotipe Virus Dengue dan Gambaran Manifestasi Klinis serta Hematologi Rutin pada Infeksi Virus Dengue

    Directory of Open Access Journals (Sweden)

    Basti Andriyoko

    2012-12-01

    Full Text Available All DENV serotypes can cause a spectrum of disease from dengue fever (DF to dengue hemorrhagic fever (DHF and dengue shock syndrome (DSS. It is difficult to differentiate clinical characteristicand hematologic result for each serotype. Aim of this study were to determine dengue serotype and describe clinical manifestation of DF, DHF, DSS and routine hematologic results, i.e.haemoglobin, hematocrit, leukocyte, and thrombocyte in each serotype. This study was conducted at Dr. Hasan Sadikin Hospital Bandung from March 2010 until July 2011. Subjects were dengue patients aged >14 years with a history of fever <5 days. Blood samples were taken for serotype determination by reverse transcription polymerase chain reaction (RT-PCR followed by semi-nested PCR. Clinical manifestation data and haematologic result were obtained from medical records. This was a descriptive study. Seventy five patients were included in this study. Dengue serotype can be detected in 27 (36% samples with DENV-3 (13 were dominating followed by DENV-2 (8, DENV-4 (4, and DENV-1 (2. DHF was mainly found in DENV-3. DENV-2 gavethe highest decrease in hemoglobin, highest percentage increase in haematocrit, lowest leukocyte, and lowest thrombocyte. In conclusion, all 4 serotypes are found in RSUP Dr. Hasan Sadikin Hospital Bandung with DENV-3 domination. DHF is mainly caused by DENV-3.

  3. O Programa Novas Oportunidades numa agenda globalmente estruturada para a educação

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    Marcelo Marques

    2013-05-01

    Full Text Available http://dx.doi.org/10.5007/2175-795X.2013v31n2p425 Este artigo apresenta uma análise crítica da criação e implementação da mais emblemática medida política para o campo de jovens e adultos pouco escolarizados em Portugal: o Programa Novas Oportunidades. Recorrendo à proposta de Roger Dale sobre a agenda globalmente estruturada para a educação, discutiu-se a fabricação desta medida a partir de um cenário de regulação transnacional. Através da análise documental de um conjunto de documentos europeus e nacionais entre o período de 2000 e 2010 para o campo da educação de jovens e adultos, verificou-se que Programa Novas Oportunidades é consequência de um fortalecimento do processo de regulação das políticas educativas, levado a cabo pela União Europeia. Este fortalecimento resultou na construção de um programa político para o campo da educação de jovens e adultos em Portugal que comunga não só das mesmas ideologias instrumentais para a educação da União Europeia, como de uma gestão tecnocrática das políticas educativas, assente na procura de resultados.

  4. Current perspectives on the spread of dengue in India

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    Gupta E

    2014-12-01

    Full Text Available Ekta Gupta, Neha Ballani Department of Clinical Virology, Institute of Liver and Biliary Sciences, New Delhi, IndiaAbstract: Dengue fever (DF and dengue hemorrhagic fever (DHF are important arthropod-borne viral diseases. Each year, there are ~50 million dengue infections and ~500,000 individuals are hospitalized with DHF, mainly in Southeast Asia. Dengue in India has dramatically expanded over the last few decades, with rapidly changing epidemiology. The first major DHF outbreak in the entire nation occurred in 1996 by dengue virus serotype 2, and after a gap of almost a decade, the country faced yet another DF outbreak in the year 2003 by dengue virus serotype 3. A dramatic increase in the number and frequency of outbreaks followed, and, at present, in most of the states of India, dengue is almost endemic. At present, all the four serotypes are seen in circulation, but the predominant serotype keeps changing. Despite this trend, surveillance, reporting, and diagnosis of dengue remain largely passive in India. More active community-based epidemiological studies with intensive vector control and initiatives for dengue vaccine development should be geared up to control the spread of dengue in India. We review here the factors that may have contributed to the changing epidemiology of dengue in India.Keywords: dengue, epidemiology, India, pathogenesis, vaccine

  5. Wissadula Medik. (Malvaceae no Brasil: novas espécies e combinação Wissadula Medik. (Malvaceae in Brazil: new species and combination

    Directory of Open Access Journals (Sweden)

    Massimo G. Bovini

    2010-06-01

    Full Text Available Duas novas espécies e uma nova combinação são apresentadas para o gênero Wissadula (Malvaceae: Wissadula delicata Bovini, W. krapovickasiana Bovini e Wissadula caribea (DC. Bovini, respectivamente, além de novos sinônimos. Para as espécies apresentadas, são fornecidas descrições, ilustrações e chaves de reconhecimento para distingui-las das espécies relacionadas.Two new species and a new combination are presented for genus Wissadula (Malvaceae: Wissadula krapovickasiana Bovini, W. delicata Bovini and Wissadula caribea (DC. Bovini, respectively, plus new synonyms. Descriptions, illustrations and keys to distinguish these species from similar species are supplied.

  6. Nova abordagem metodológica para locação, modelagem 3D e monitoramento de barragens subterrâneas no semiárido brasileiro

    OpenAIRE

    Lima, Alexandre de Oliveira

    2013-01-01

    Apesar do número significativo de barragens construídas nos últimos anos no Brasil e mesmo em outros países, são poucos os estudos técnicos que dão suporte a este crescimento. Com o objetivo de propor uma nova abordagem metodológica para o processo de locação e monitoramento de barragens subterrâneas, em condições de clima semiárido, foram realizados estudos em duas sub-bacias hidrográficas (do rio das Cobras e Pau Lavrado) ambas situadas no semiárido do Estado do Rio Grande. Nesta nova abord...

  7. Community Genetics: a new discipline and its application in Brazil Genética Comunitária: uma nova disciplina e sua aplicação no Brasil

    Directory of Open Access Journals (Sweden)

    Antonio Sérgio Ramalho

    2000-01-01

    Full Text Available Community genetics is a new discipline which aims to provide genetic services to the community as a whole. As a science, community genetics encompasses all research needed to develop and evaluate its application. There is no question that the development of community genetics is necessary in Brazil. The implementation of such programs in our country, especially for hemoglobinopathies, has been recommended by the World Health Organization and other international organizations. Apart from the need for and appeal of community genetics programs, some aspects require serious review. This article discusses various cultural, social, psychological, and economic factors that can make genetic screening an invasion of individual privacyA Genética Comunitária é uma nova disciplina, que tem por objetivo o fornecimento de serviços de genética para a comunidade como um todo. Enquanto ciência, engloba todas as pesquisas necessárias ao desenvolvimento e à avaliação das suas aplicações. Indiscutivelmente, o desenvolvimento da disciplina no Brasil é muito necessário e a implantação de programas brasileiros de genética comunitária vem sendo recomendada pela Organização Mundial de Saúde e por outras organizações internacionais, sobretudo para as hemoglobinopatias. Apesar da necessidade e do lado atraente dos programas comunitários, alguns aspectos destes devem ser seriamente considerados. No presente artigo, são discutidos alguns fatores culturais, sociais, psicológicos e econômicos que podem transformar a triagem genética em uma invasão da privacidade dos indivíduos.

  8. Alergia às Proteínas do Leite de Vaca: Uma Nova Era

    Directory of Open Access Journals (Sweden)

    Filipe Benito Garcia

    2016-01-01

    lhe atualmente uma dieta livre. Esta estratégia terapêutica mostra-se revolucionária por permitir modificar a história natural da alergia às proteínas do leite de vaca grave e persistente, com impacto muito positivo na qualidade de vida dos doentes e da sua família.

  9. Dengue in the South-eastern region of Brazil: historical analysis and epidemiology Dengue na região sudeste do Brasil: análise histórica e soroepidemiológica

    Directory of Open Access Journals (Sweden)

    José Carlos Serufo

    1993-06-01

    -Elisa, inibição da hemaglutinação, isolamento e tipagem. Foram avaliados os níveis de intoxicação de trabalhadores por inseticidas organofosforado, através de dosagem da colinesterase. Foram coletados 1.989 soros de pessoas com quadro febril não identificado em 28 municípios, sendo constatada a ocorrência de dengue em 17 e comprovada autoctonia em 14 municípios. Foi isolado sorotipo 1. A dosagem de colinesterase de 2.391 soros mostrou 53 casos com alterações, sendo comprovados 3 casos de intoxicação. Os resultados mostraram uma epidemia de proporções maiores do que a oficialmente conhecida. A distribuição ampla do vetor traz inquietação quanto à possibilidade de reurbanização da febre amarela silvestre, enquanto a não detecção do A. aegypti em 2 municípios com autoctonia levanta a possibilidade do envolvimento de outros vetores. Como não existe ainda vacina contra o dengue, o combate ao vetor é a medida eficaz na prevenção de surtos. A erradicação do vetor depende de decisão governamental que envolva a organização do sistema de saúde e a participação de todos os meios e formas de repasse de informação, uma vez que o resultado a médio e longo prazo depende especialmente da capacitação popular e sua participação ostensiva.

  10. Facing dengue fever - our first experience

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    Cvjetković Dejan

    2017-01-01

    Full Text Available Introduction. Dengue fever is a mosquito-borne disease caused by dengue virus, endemic in tropical and subtropical regions, where it is mostly imported from. The most common clinical form is classic dengue fever. We presented the first dengue case microbiologically confirmed in Serbia. Case report. A 34-year-old male got classic dengue fever after arrival from Cuba. The disease occurred suddenly with fever, myalgias, skin rash, hepatosplenomegaly, cytopenia, abnormal aminotransferase and creatine kinase levels. The diagnosis was confirmed with virological diagnostic methods. Significant leukopenia and thrombocytopenia as well as elevation of serum creatine kinase activity were recorded from the very beginning of hospitalization, but were gradually normalized. The whole duration of hospitalization was accompanied by laboratory signs of liver lesion. The disease had favourable outcome. At hospital discharge, the patient was afebrile, asymptomatic, with discrete erythematous rash on torso and arms, normal hemathological values and creatine kinase level and moderately elevated alanine-aminotransferase level. Conclusion. Considering global climate changes and growing international traffic, our health care service needs to be ready for possible massive outbreaks of dengue and other tropical infectious diseases in forthcoming years.

  11. Seropositivity of Dengue Antibodies during Pregnancy

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    Nor Azlin Mohamed Ismail

    2014-01-01

    Full Text Available Purpose. Malaysia a dengue endemic country with dengue infections in pregnancy on the rise. The present study was aimed at determining dengue seroprevalence (IgG or IgM during pregnancy and its neonatal transmission in dengue seropositive women. Methods. Maternal with paired cord blood samples were tested for dengue antibodies (IgG and IgM using an enzyme-linked immunosorbent assay (ELISA. Maternal age, parity, occupation, ethnic group, and gestational age were recorded. Data on neonatal Apgar score and admissions to the Neonatal Intensive Care Unit (NICU were analyzed. Results. Out of 358 women recruited, about 128 (35.8% patients were seropositive. Twelve patients (3.4% had recent infections (IgM positive and another 116 women (32.4% were with past infections (IgG positive. All babies born to seropositive mothers had positive IgG paired cord blood; however, no IgM seropositivity was observed. All neonates had good Apgar scores and did not require NICU admission. Conclusion. In this study, 35.8% pregnant women were found to be dengue seropositive. However, transplacental transfer of IgG antibodies had no detrimental effect on the neonatal outcomes.

  12. Cerebellar liponeurocytoma: a newly recognized clinico-pathological entity Liponeurocitoma cerebelar: uma nova entidade clínico-patológica

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    Nádia Montagna

    2002-09-01

    Full Text Available The term "cerebellar liponeurocytoma", recently adopted by the World Health Organization Working Group (WHO, replaced many other different terms used up to now to give name to this rare tumor. To our knowledge, less than 20 cases have been related up to now under different names like as "lipomatous medulloblastoma, lipidized medulloblastoma, neurolipocytoma, medullocytoma and lipomatous glioneurocytoma". The new nomenclature eliminates the word "medulloblastoma", reinforces its benign caracter, and includes it in the category of glioneuronal tumors. We describe an adictional case of this distinct clinico-pathological entity removed from the right cerebellar hemisphere of a 53-year-old woman. With the present case report, we hope to contribute to the knowledge on the diagnostic and prognostic implications derived from the finding of mature adipose-like tissue within a medulloblastomatous tumour.O termo "liponeurocitoma cerebelar" recentemente adotado pela Organização Mundial de Saúde (Classificação de Tumores Cerebrais - versão 2000, surgiu em substituição a vários outros utilizados até então, para denominar esta rara neoplasia. De nosso conhecimento há na literatura menos de 20 casos relatados sob termos diferentes tais como "meduloblastoma lipomatoso, meduloblastoma lipidizado, neurolipocitoma, medulocitoma e glioneurocitoma lipomatoso". A nova nomenclatura elimina a palavra "meduloblastoma", enfatiza seu caráter benigno e o coloca na categoria dos tumores glioneuronais. Descrevemos mais um caso desta rara entidade clínico-patológica, ressecada do hemisfério cerebelar direito em uma mulher de 53 anos. Com este caso esperamos contribuir para o melhor conhecimento sobre o diagnóstico, prognóstico e possibilidades terapêuticas advindas da presença de tecido adiposo em tumor meduloblastomatoso de adultos.

  13. Mediational Effects of Self-Efficacy Dimensions in the Relationship between Knowledge of Dengue and Dengue Preventive Behaviour with Respect to Control of Dengue Outbreaks: A Structural Equation Model of a Cross-Sectional Survey

    Science.gov (United States)

    Isa, Affendi; Loke, Yoon K.; Smith, Jane R.; Papageorgiou, Alexia; Hunter, Paul R.

    2013-01-01

    Background Dengue fever is endemic in Malaysia, with frequent major outbreaks in urban areas. The major control strategy relies on health promotional campaigns aimed at encouraging people to reduce mosquito breeding sites close to people's homes. However, such campaigns have not always been 100% effective. The concept of self-efficacy is an area of increasing research interest in understanding how health promotion can be most effective. This paper reports on a study of the impact of self-efficacy on dengue knowledge and dengue preventive behaviour. Methods and Findings We recruited 280 adults from 27 post-outbreak villages in the state of Terengganu, east coast of Malaysia. Measures of health promotion and educational intervention activities and types of communication during outbreak, level of dengue knowledge, level and strength of self-efficacy and dengue preventive behaviour were obtained via face-to-face interviews and questionnaires. A structural equation model was tested and fitted the data well (χ2 = 71.659, df = 40, p = 0.002, RMSEA = 0.053, CFI = 0.973, TLI = 0.963). Mass media, local contact and direct information-giving sessions significantly predicted level of knowledge of dengue. Level and strength of self-efficacy fully mediated the relationship between knowledge of dengue and dengue preventive behaviours. Strength of self-efficacy acted as partial mediator in the relationship between knowledge of dengue and dengue preventive behaviours. Conclusions To control and prevent dengue outbreaks by behavioural measures, health promotion and educational interventions during outbreaks should now focus on those approaches that are most likely to increase the level and strength of self-efficacy. PMID:24086777

  14. A "nova classe média": repercussões psicossociais em famílias brasileiras

    Directory of Open Access Journals (Sweden)

    Luís Fernando de Oliveira Saraiva

    2015-04-01

    Full Text Available O presente artigo, em uma abordagem ensaística, tem como objetivo analisar efeitos psicossociais na constituição de modos de subjetivação e em famílias a partir da emergência daquilo que vem sendo nomeado de a "nova classe média brasileira". Para isto, primeiramente foi feita revisão bibliográfica de como a sociologia, economia e antropologia vem conceituando e caracterizando esta nova classe social, considerando que não há estudos acerca desse tema na Psicologia. A partir do diálogo com fontes midiáticas, buscou-se pensar como vem sendo operada a construção de um "estilo de vida" marcado pela tentativa de planejamento do futuro, consumo e meritocracia. Tais características mostram-se importantes formas de aproximação com a classe média tradicional. Por fim, buscou-se entender como famílias vêm vivenciando tais mudanças em seu cotidiano, organização e relações.

  15. Dengue in Grenada El dengue en el país de Granada

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    André Panagos

    2005-04-01

    Full Text Available OBJECTIVES: Dengue fever is endemic in the country of Grenada and is grossly underreported as a source of morbidity. The goal of this study was to assess the status of dengue fever in a representative community in Grenada. METHODS: Surveys were conducted in the Mont Tout/Grand Anse Valley area in the parish of St. George's from March to June 1996. The objectives of the survey were to: (1 to assess the knowledge, attitudes, and practices (KAP of residents; (2 to determine the presence of larval and adult Aedes aegypti and their potential breeding sites; and (3 to identify the seroprevalence of specific immunoglobulin G (IgG dengue antibodies in the local population. RESULTS: Out of the 102 respondents to the KAP survey, 100 of them (98% reported never having had dengue fever. Of the 75 persons who agreed to have blood samples taken, 70 of them (93% (95% confidence interval = 85.1%-97.8% tested positive with the IgG enzyme-linked immunosorbent assay, indicating past exposure. In terms of water storage, 98 of 102 respondents (96% stored fresh water in containers. The vector survey found 57 of the 102 households (56% had Ae. aegypti larvae in water containers on their property, and 94 of 102 dwellings (92% had adult Ae. aegypti mosquitoes indoors. CONCLUSIONS: Although many people were familiar with dengue fever and mosquitoes, the 1996 survey found that their knowledge of the important relationships among mosquitoes, human behavior, and disease transmission was incomplete. Since 1996, continued education efforts have been made in the public school system and with national public health campaigns, yet little effort has been specifically targeted towards our study community. These data suggest Grenada has a need for continued community education that addresses dengue fever transmission and Ae. aegypti reduction.OBJETIVOS: La fiebre del dengue es endémica en el país caribeño de Granada y es grande su subnotificación como fuente de morbilidad. El

  16. Indústria fonográfica e a Nova Produção Independente: o futuro da música brasileira?

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    Leonardo De Marchi

    2008-09-01

    Full Text Available Neste artigo, relaciona-se a rápida consolidação da indústria fonográfica independente no Brasil, ou Nova Produção Independente, às transformações promovidas pelas novas tecnologias da informação e da comunicação e pela recente economia do entretenimento. Argumenta-se que o surgimento dessas empresas se dá não por uma “crise” da indústria de música, mas pela complexificação da cadeia produtiva da fonografia, reorganizada pelo surgimento de novas tecnologias e hábitos de consumo de gravações sonoras na era digital. Palavras-chave: Indústria fonográfica brasileira; produção independente; novas tecnologias da informação e da comunicação. ABSTRACT In the article, the fast consolidation of the Brazilian phonographic independent industry, or New Independent Production, is related to the transformations promoted by the new information and communication technologies and the new entertainment economy. As argued, the appearance of these companies does not result from a “crisis” of the music industry, but from the complexification of the phonographic productive chain, reorganized by the appearance of new technologies and habits of consumption of sound recordings in the digital era. Keywords: Brazilian phonographic industry; indies; new information and communication technologies.

  17. UMA VISÃO GERAL SOBRE A INTERNET DAS COISAS

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    Gustavo Marin Suppi

    2017-02-01

    Full Text Available No decorrer dos anos, a tecnologia computacional tem evoluído, com os dispositivos móveis abriu um imenso leque de possibilidades de sistemas que visam facilitar a vida de toda a sociedade. Na Internet das Coisas, a conexão não se limita a esses dispositivos, mas a qualquer objeto no ambiente, desde torneiras até sinaleiras, onde formam uma estrutura de rede guiada por troca de informações, onde sensores captam informações do meio e enviam para dispositivos que as processam. Por meio de uma revisão de literatura, o objetivo foi coletar dados sobre essa nova infraestrutura, proporcionando ao leitor uma visão geral, expondo os principais pontos mencionados pelos autores dos artigos pesquisados. Concluiu-se que o objetivo da Internet das Coisas é de fato revolucionar o meio de como usamos a internet, desde a conectividade até a distribuição da informação, porém, para tal, será necessário fortes estudos em relação a segurança das informações obtidas dos usuários.

  18. Dengue and dengue haemorrhagic fever: Indian perspective

    Indian Academy of Sciences (India)

    PRAKASH KUMAR

    mainly in children (Halstead 2002, 2007; Chaturvedi and. Shrivastava 2004). Dengue ... of molecular epidemiology, immunopathology and vaccine development. Selected work done in ..... Only the Indian initiative in this field is presented here.

  19. O Taylorismo sob controle: o lugar das novas e velhas tecnologias na ordem industrial.

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    Lucas Frazão Silva

    2006-03-01

    Full Text Available Este artigo discute criticamente o possível esgotamento histórico do taylorismo. Pretende apontar que, passados praticamente 100 anos desde sua difusão inicial, as formas de controle propostas pela administração científica foram aprimoradas, modernizadas e transformadas a tal ponto que parecem superadas historicamente. No entanto, a rápida difusão de sistemas eletrônicos de segurança no mundo corporativo representa uma evidência concreta da perenidade das formas tayloristas de controle que, transmutadas, assumem novas características no atual paradigma tecno-produtivo.

  20. Epidemiology of dengue: past, present and future prospects

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    Murray NE

    2013-08-01

    Full Text Available Natasha Evelyn Anne Murray,1,2 Mikkel B Quam,1 Annelies Wilder-Smith1,31Institute of Public Health, University of Heidelberg, Heidelberg, Germany; 2Population Health, Waikato District Health Board, Hamilton, New Zealand; 3Lee Kong Chian School of Medicine, Nanyang Technological University, SingaporeAbstract: Dengue is currently regarded globally as the most important mosquito-borne viral disease. A history of symptoms compatible with dengue can be traced back to the Chin Dynasty of 265–420 AD. The virus and its vectors have now become widely distributed throughout tropical and subtropical regions of the world, particularly over the last half-century. Significant geographic expansion has been coupled with rapid increases in incident cases, epidemics, and hyperendemicity, leading to the more severe forms of dengue. Transmission of dengue is now present in every World Health Organization (WHO region of the world and more than 125 countries are known to be dengue endemic. The true impact of dengue globally is difficult to ascertain due to factors such as inadequate disease surveillance, misdiagnosis, and low levels of reporting. Currently available data likely grossly underestimates the social, economic, and disease burden. Estimates of the global incidence of dengue infections per year have ranged between 50 million and 200 million; however, recent estimates using cartographic approaches suggest this number is closer to almost 400 million. The expansion of dengue is expected to increase due to factors such as the modern dynamics of climate change, globalization, travel, trade, socioeconomics, settlement and also viral evolution. No vaccine or specific antiviral therapy currently exists to address the growing threat of dengue. Prompt case detection and appropriate clinical management can reduce the mortality from severe dengue. Effective vector control is the mainstay of dengue prevention and control. Surveillance and improved reporting of dengue

  1. Irregular water supply, household usage and dengue: a bio-social study in the Brazilian Northeast Abastecimento irregular de água, seu uso domiciliar e dengue: uma pesquisa biossocial no Nordeste do Brasil

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    Andrea Caprara

    2009-01-01

    Full Text Available Despite increased vector control efforts, dengue fever remains endemic in Fortaleza, Northeast Brazil, where sporadic epidemic outbreaks have occurred since 1986. Multiple factors affect vector ecology such as social policy, migration, urbanization, city water supply, garbage disposal and housing conditions, as well as community level understanding of the disease and related practices. This descriptive study used a multi-disciplinary approach that bridged anthropology and entomology. A multiple case study design was adopted to include research in six study areas, defined as blocks. The water supply is irregular in households from both under-privileged and privileged areas, however, clear differences exist. In the more privileged blocks, several homes are not connected to the public water system, but have a well and pump system and therefore irregularity of supply does not affect them. In households from under-privileged blocks, where the water supply is irregular, the frequent use of water containers such as water tanks, cisterns, barrels and pots, creates environmental conditions with a greater number of breeding areas. In under-privileged homes, there are more possible breeding areas and environmental conditions that may improve the chances of Aedes aegypti survival.Apesar do crescimento de esforços no controle, desde 1986, a dengue, em Fortaleza, Nordeste do Brasil, continua endêmica com esporádicos surtos epidêmicos. Diversos fatores influenciam a ecologia do vetor, como as políticas sociais, a migração, a urbanização, o abastecimento urbano de água, a coleta de resíduos sólidos, as condições das casas, assim como as interpretações e práticas da comunidade. Este estudo descritivo utiliza uma abordagem multidisciplinar conjugando a antropologia e a entomologia. Foi adotado um desenho de estudo de caso múltiplo em seis quarteirões da cidade. O abastecimento de água é irregular seja nas casas pobres, seja naquelas

  2. NOVA.

    Science.gov (United States)

    WGBH-TV, Boston, MA.

    News clippings, reviews, and feature articles about the Public Broadcasting System science-adventure series "Nova" are collected here. Included are comments from the New York Times, Washington Post, Christian Science Monitor, and TV Guide. Commentaries are primarily favorable and include synopses of various episodes. (DGC)

  3. FEVER AS INDICATOR TO SECONDARY INFECTION IN DENGUE VIRAL INFECTION

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    Soegeng Soegijanto

    2018-04-01

    Full Text Available Dengue Virus Infections are distributed in tropical and sub-tropical regions and transmitted by the mosquitoes such as Aedes aegypti and Aedes albopictus. Dengue virus can cause dengue fever, dengue hemorrhagic fever and dengue shock syndrome or dengue and severe dengue classified by World Health Organization. Beside it concurrent infection virus salmonella had been found some cases who showed fever more than 7 days. Concurrent infection with two agents can result in an illness having overlapping symptoms creating a diagnostic dilemma for treating physician, such as dengue fever with typhoid fever. The aim of this research is detection of dengue virus and secondary infection with Salmonella typhi in patients suspected dengue virus infection. Detection of dengue virus and Salmonella typhi using immunochromatography test such as NS1, IgG/IgM for dengue virus infection, and IgM/IgG Salmonella and blood culture. The fifty children with dengue virus infection came to Soerya hospital and 17 cases suspected dengue virus infection, five cases showed a positive NS1 on the second day of fever and one case concurrent with clinical manifestation of convulsi on the third days of fever there were five cases only showed positive. It was showed in this study that on the fourth to six day of fever in dengue virus infection accompanied by antibody IgM & IgG dengue. There were 12 cases showed the clinical manifestation of concurrent dengue viral infection and Salmonella, all of them showed a mild clinical manifestation and did not show plasma leakage and shock. In this study we found the length of stay of concurrent Dengue Virus Infection and Salmonella infection is more than 10 days. These patients were also more likely to have co-existing haemodynamic disturbances and bacterial septicaemia which would have required treatment with inotropes and antibiotics. This idea is very important to make update dengue viral management to decrease mortality in outbreak try to

  4. Recurrent Novae — A Review

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    K. Mukai

    2015-02-01

    Full Text Available In recent years, recurrent nova eruptions are often observed very intensely in wide range of wavelengths from radio to optical to X-rays. Here I present selected highlights from recent multi-wavelength observations. The enigma of T Pyx is at the heart of this paper. While our current understanding of CV and symbiotic star evolution can explain why certain subset of recurrent novae have high accretion rate, that of T Pyx must be greatly elevated compared to the evolutionary mean. At the same time, we have extensive data to be able to estimate how the nova envelope was ejected in T Pyx, and it turns to be a rather complex tale. One suspects that envelope ejection in recurrent and classical novae in general is more complicated than the textbook descriptions. At the end of the review, I will speculate that these two may be connected.

  5. Peptides as Therapeutic Agents for Dengue Virus.

    Science.gov (United States)

    Chew, Miaw-Fang; Poh, Keat-Seong; Poh, Chit-Laa

    2017-01-01

    Dengue is an important global threat caused by dengue virus (DENV) that records an estimated 390 million infections annually. Despite the availability of CYD-TDV as a commercial vaccine, its long-term efficacy against all four dengue virus serotypes remains unsatisfactory. There is therefore an urgent need for the development of antiviral drugs for the treatment of dengue. Peptide was once a neglected choice of medical treatment but it has lately regained interest from the pharmaceutical industry following pioneering advancements in technology. In this review, the design of peptide drugs, antiviral activities and mechanisms of peptides and peptidomimetics (modified peptides) action against dengue virus are discussed. The development of peptides as inhibitors for viral entry, replication and translation is also described, with a focus on the three main targets, namely, the host cell receptors, viral structural proteins and viral non-structural proteins. The antiviral peptides designed based on these approaches may lead to the discovery of novel anti-DENV therapeutics that can treat dengue patients.

  6. Identifying and quantifying recurrent novae masquerading as classical novae

    International Nuclear Information System (INIS)

    Pagnotta, Ashley; Schaefer, Bradley E.

    2014-01-01

    Recurrent novae (RNe) are cataclysmic variables with two or more nova eruptions within a century. Classical novae (CNe) are similar systems with only one such eruption. Many of the so-called CNe are actually RNe for which only one eruption has been discovered. Since RNe are candidate Type Ia supernova progenitors, it is important to know whether there are enough in our Galaxy to provide the supernova rate, and therefore to know how many RNe are masquerading as CNe. To quantify this, we collected all available information on the light curves and spectra of a Galactic, time-limited sample of 237 CNe and the 10 known RNe, as well as exhaustive discovery efficiency records. We recognize RNe as having (1) outburst amplitude smaller than 14.5 – 4.5 × log (t 3 ), (2) orbital period >0.6 days, (3) infrared colors of J – H > 0.7 mag and H – K > 0.1 mag, (4) FWHM of Hα > 2000 km s –1 , (5) high excitation lines, such as Fe X or He II near peak, (6) eruption light curves with a plateau, and (7) white dwarf mass greater than 1.2 M ☉ . Using these criteria, we identify V1721 Aql, DE Cir, CP Cru, KT Eri, V838 Her, V2672 Oph, V4160 Sgr, V4643 Sgr, V4739 Sgr, and V477 Sct as strong RN candidates. We evaluate the RN fraction among the known CNe using three methods to get 24% ± 4%, 12% ± 3%, and 35% ± 3%. With roughly a quarter of the 394 known Galactic novae actually being RNe, there should be approximately a hundred such systems masquerading as CNe.

  7. Dengue

    Science.gov (United States)

    ... emerged as a worldwide problem only since the 1950s. Although dengue rarely occurs in the continental United ... OIG 1600 Clifton Road Atlanta , GA 30329-4027 USA 800-CDC-INFO (800-232-4636) , TTY: 888- ...

  8. Analysis of the spatial distribution of dengue cases in the city of Rio de Janeiro, 2011 and 2012.

    Science.gov (United States)

    Carvalho, Silvia; Magalhães, Mônica de Avelar Figueiredo Mafra; Medronho, Roberto de Andrade

    2017-08-17

    ferramenta Geocoding do programa ArcGis10. A análise espacial foi feita a partir do estimador de densidade Kernel. A densidade de Kernel apontou áreas quentes para dengue clássico não coincidente geograficamente a dengue grave, estando localizadas dentro ou próximas de favelas. O cálculo da razão de Kernel não apresentou modificação significativa no padrão de distribuição espacial observados na análise da densidade de Kernel. O processo de georreferenciamento mostrou perda de 41% dos registros de dengue clássico e 17% de dengue grave devido ao endereçamento da ficha do Sistema de Informação de Agravos de Notificação. As áreas quentes próximas às favelas sugerem que a vulnerabilidade social existente nessas localidades pode ser um fator de influência para a ocorrência desse agravo, uma vez que há deficiência da oferta e acesso a bens e serviços essenciais para a população. Para diminuir essa vulnerabilidade, as intervenções devem estar relacionadas a políticas macroeconômicas.

  9. Clinico-laboratory spectrum of dengue viral infection and risk factors associated with dengue hemorrhagic fever: a retrospective study.

    Science.gov (United States)

    Mallhi, Tauqeer Hussain; Khan, Amer Hayat; Adnan, Azreen Syazril; Sarriff, Azmi; Khan, Yusra Habib; Jummaat, Fauziah

    2015-09-30

    The incidence of dengue is rising steadily in Malaysia since the first major outbreak in 1973. Despite aggressive measures taken by the relevant authorities, Malaysia is still facing worsening dengue crisis over the past few years. There is an urgent need to evaluate dengue cases for better understanding of clinic-laboratory spectrum in order to combat this disease. A retrospective analysis of dengue patients admitted to a tertiary care teaching hospital during the period of six years (2008 - 2013) was performed. Patient's demographics, clinical and laboratory findings were recorded via structured data collection form. Patients were categorized into dengue fever (DF) and dengue hemorrhagic fever (DHF). Appropriate statistical methods were used to compare these two groups in order to determine difference in clinico-laboratory characteristics and to identify independent risk factors of DHF. A total 667 dengue patients (30.69 ± 16.13 years; Male: 56.7 %) were reviewed. Typical manifestations of dengue like fever, myalgia, arthralgia, headache, vomiting, abdominal pain and skin rash were observed in more than 40 % patients. DHF was observed in 79 (11.8 %) cases. Skin rash, dehydration, shortness of breath, pleural effusion and thick gall bladder were more significantly (P  40 years (OR: 4.1, P hospitalization (OR: 2.3, P = 0.037) as independent predictors of DHF. Overall mortality was 1.2 % in our study. Current study demonstrated that DF and DHF present significantly different clinico-laboratory profile. Older age, secondary infection, diabetes mellitus, lethargy, thick gallbladder and delayed hospitalization significantly predict DHF. Prior knowledge of expected clinical profile and predictors of DHF/DSS development would provide information to identify individuals at higher risk and on the other hand, give sufficient time to clinicians for reducing dengue related morbidity and mortality.

  10. An expanded dengue syndrome patient with manifestation myocarditis: case report

    Science.gov (United States)

    Arifijanto, M. V.; Luqmana, H. P.; Rusli, M.; Bramantono

    2018-03-01

    Dengue infection may manifest asymptomatic, dengue fever, dengue hemorrhagic fever, dengue shock syndrome. However, atypical manifestations in other organs have been increasingly reported and called expanded dengue syndrome. One of the cardiac complications in dengue is myocarditis. An 18-year-old woman complains of high fever since 3 days, epistaxis, chest pain, dyspnea, and vomiting. Laboratory examination obtained thrombocytopenia, hemoconcentration, NS1, IgG-IgM dengue positive, CKMB and Troponin- I increase. Electrocardiogram result ischemic anterior-posterior. Echocardiography results hyperechogenic on myocardial suspicious a myocarditis. The patient was diagnosed with acute myocarditis and dengue hemorrhagic fever. Condition improved after five days of treatment. Cardiac complications in dengue are now increasingly observed with the most common case is myocarditis. The main mechanism of dengue myocarditis is still unknown though both direct viral infection and immune mediated damage have been suggested to be the cause of myocardial damage. The low incidence of dengue myocarditis is because it’s asymptomatic and diagnosis is easily missed. Almost all cases of dengue myocarditis are self-limiting and severe myocarditis leading to dilated cardiomyopathy is extremely rare. There have been reported a patient with dengue hemorrhagic fever with manifestation myocarditis. Condition improve with supportive management.

  11. Clinical profile and outcome of Dengue fever cases.

    Science.gov (United States)

    Ratageri, Vinod H; Shepur, T A; Wari, P K; Chavan, S C; Mujahid, I B; Yergolkar, P N

    2005-08-01

    Dengue fever is on rise globally. In India, Dengue epidemics are expanding geographically, even into the rural areas. Dengue can present with varied manifestations. The mortality rate has been brought down with high index of suspicion, strict monitoring and proper fluid resuscitation. Herewith, we are presenting clinical features and outcome of Dengue cases seen in and around Hubli (North Karnataka).

  12. Dengue Infection in Children in Ratchaburi, Thailand: A Cohort Study. I. Epidemiology of Symptomatic Acute Dengue Infection in Children, 2006–2009

    Science.gov (United States)

    Sabchareon, Arunee; Sirivichayakul, Chukiat; Limkittikul, Kriengsak; Chanthavanich, Pornthep; Suvannadabba, Saravudh; Jiwariyavej, Vithaya; Dulyachai, Wut; Pengsaa, Krisana; Margolis, Harold S.; Letson, G. William

    2012-01-01

    Background There is an urgent need to field test dengue vaccines to determine their role in the control of the disease. Our aims were to study dengue epidemiology and prepare the site for a dengue vaccine efficacy trial. Methods and Findings We performed a prospective cohort study of children in primary schools in central Thailand from 2006 through 2009. We assessed the epidemiology of dengue by active fever surveillance for acute febrile illness as detected by school absenteeism and telephone contact of parents, and dengue diagnostic testing. Dengue accounted for 394 (6.74%) of the 5,842 febrile cases identified in 2882, 3104, 2717 and 2312 student person-years over the four years, respectively. Dengue incidence was 1.77% in 2006, 3.58% in 2007, 5.74% in 2008 and 3.29% in 2009. Mean dengue incidence over the 4 years was 3.6%. Dengue virus (DENV) types were determined in 333 (84.5%) of positive specimens; DENV serotype 1 (DENV-1) was the most common (43%), followed by DENV-2 (29%), DENV-3 (20%) and DENV-4 (8%). Disease severity ranged from dengue hemorrhagic fever (DHF) in 42 (10.5%) cases, dengue fever (DF) in 142 (35.5%) cases and undifferentiated fever (UF) in 210 (52.5%) cases. All four DENV serotypes were involved in all disease severity. A majority of cases had secondary DENV infection, 95% in DHF, 88.7% in DF and 81.9% in UF. Two DHF (0.5%) cases had primary DENV-3 infection. Conclusion The results illustrate the high incidence of dengue with all four DENV serotypes in primary school children, with approximately 50% of disease manifesting as mild clinical symptoms of UF, not meeting the 1997 WHO criteria for dengue. Severe disease (DHF) occurred in one tenth of cases. Data of this type are required for clinical trials to evaluate the efficacy of dengue vaccines in large scale clinical trials. PMID:22860141

  13. A Case of Dengue Maculopathy with Spontaneous Recovery

    Directory of Open Access Journals (Sweden)

    Fiona Oi-jing Luk

    2013-06-01

    Full Text Available Purpose: To report a case of dengue maculopathy, which resolved spontaneously without treatment. Methods: A 25-year-old female patient with good past health was admitted to a general hospital in Hong Kong with fever of unknown origin after traveling to Indonesia. Based on the clinical features and a positive real-time polymerase chain reaction for dengue virus type 1, she was diagnosed with dengue fever. The patient developed dengue maculopathy mainly affecting the vision of her left eye. Abnormalities on a multifocal electroretinogram showed bilateral involvement. Results: As there is no proven treatment for dengue maculopathy, the patient opted for observation. Her vision returned to normal within 3 weeks. Conclusion: Dengue maculopathy can cause severe visual loss and may resolve without treatment.

  14. Severe Dengue Fever Outbreak in Taiwan.

    Science.gov (United States)

    Wang, Sheng-Fan; Wang, Wen-Hung; Chang, Ko; Chen, Yen-Hsu; Tseng, Sung-Pin; Yen, Chia-Hung; Wu, Deng-Chyang; Chen, Yi-Ming Arthur

    2016-01-01

    Dengue fever (DF) is a vector-borne disease caused by dengue viruses (DENVs). Epidemic dengue occurs intermittently in Taiwan. In 2014, Taiwan experienced its largest DF outbreak. There were 15,732 DF cases reported. There were a total of 136 dengue hemorrhagic fever (DHF) cases, of which 20 resulted in death. Most DF cases were reported in southern Taiwan. A total of 15,043 (96%) cases were from Kaohsiung, a modern city in southern Taiwan. This report reviews DF epidemics in Taiwan during 2005-2014. The correlation between DF and DHF along with temperature and precipitation were conjointly examined. We conclude that most dengue epidemics in Taiwan resulted from imported DF cases. Results indicate three main factors that may have been associated with this DF outbreak in Kaohsiung: an underground pipeline explosion combined with subsequent rainfall and higher temperature. These factors may have enhanced mosquito breeding activity, facilitating DENV transmission. © The American Society of Tropical Medicine and Hygiene.

  15. Dengue in the Americas and Southeast Asia: do they differ?

    Science.gov (United States)

    Halstead, Scott B

    2006-12-01

    The populations of Southeast Asia (SE Asia) and tropical America are similar, and all four dengue viruses of Asian origin are endemic in both regions. Yet, during comparable 5-year periods, SE Asia experienced 1.16 million cases of dengue hemorrhagic fever (DHF), principally in children, whereas in the Americas there were 2.8 million dengue fever (DF) cases, principally in adults, and only 65,000 DHF cases. This review aims to explain these regional differences. In SE Asia, World War II amplified Aedes aegypti populations and the spread of dengue viruses. In the Americas, efforts to eradicate A. aegypti in the 1940s and 1950s contained dengue epidemics mainly to the Caribbean Basin. Cuba escaped infections with the American genotype dengue-2 and an Asian dengue-3 endemic in the 1960s and 1970s. Successive infections with dengue-1 and an Asian genotype dengue-2 resulted in the 1981 DHF epidemic. When this dengue-2 virus was introduced in other Caribbean countries, it encountered populations highly immune to the American genotype dengue-2. During the 1980s and 1990s, rapidly expanding populations of A. aegypti in Brazil permitted successive epidemics of dengue-1, -2, and -3. These exposures, however, resulted mainly in DF, with surprisingly few cases of DHF. The absence of high rates of severe dengue disease in Brazil, as elsewhere in the Americas, may be partly explained by the widespread prevalence of human dengue resistance genes. Understanding the nature and distribution of these genes holds promise for containing severe dengue. Future research on dengue infections should emphasize population-based designs.

  16. Dengue in the Americas and Southeast Asia: do they differ?

    Directory of Open Access Journals (Sweden)

    Scott B. Halstead

    2006-12-01

    Full Text Available The populations of Southeast Asia (SE Asia and tropical America are similar, and all four dengue viruses of Asian origin are endemic in both regions. Yet, during comparable 5-year periods, SE Asia experienced 1.16 million cases of dengue hemorrhagic fever (DHF, principally in children, whereas in the Americas there were 2.8 million dengue fever (DF cases, principally in adults, and only 65 000 DHF cases. This review aims to explain these regional differences. In SE Asia, World War II amplified Aedes aegypti populations and the spread of dengue viruses. In the Americas, efforts to eradicate A. aegypti in the 1940s and 1950s contained dengue epidemics mainly to the Caribbean Basin. Cuba escaped infections with the American genotype dengue-2 and an Asian dengue-3 endemic in the 1960s and 1970s. Successive infections with dengue-1 and an Asian genotype dengue-2 resulted in the 1981 DHF epidemic. When this dengue-2 virus was introduced in other Caribbean countries, it encountered populations highly immune to the American genotype dengue-2. During the 1980s and 1990s, rapidly expanding populations of A. aegypti in Brazil permitted successive epidemics of dengue-1, -2, and -3. These exposures, however, resulted mainly in DF, with surprisingly few cases of DHF. The absence of high rates of severe dengue disease in Brazil, as elsewhere in the Americas, may be partly explained by the widespread prevalence of human dengue resistance genes. Understanding the nature and distribution of these genes holds promise for containing severe dengue. Future research on dengue infections should emphasize population-based designs.

  17. An information value based analysis of physical and climatic factors affecting dengue fever and dengue haemorrhagic fever incidence

    Directory of Open Access Journals (Sweden)

    Tripathi Nitin

    2005-06-01

    Full Text Available Abstract Background Vector-borne diseases are the most dreaded worldwide health problems. Although many campaigns against it have been conducted, Dengue Fever (DF and Dengue Haemorrhagic Fever (DHF are still the major health problems of Thailand. The reported number of dengue incidences in 1998 for the Thailand was 129,954, of which Sukhothai province alone reported alarming number of 682. It was the second largest epidemic outbreak of dengue after 1987. Government arranges the remedial facilities as and when dengue is reported. But, the best way to control is to prevent it from happening. This will be possible only when knowledge about the relationship of DF/DHF with climatic and physio-environmental agents is discovered. This paper explores empirical relationship of climatic factors rainfall, temperature and humidity with the DF/DHF incidences using multivariate regression analysis. Also, a GIS based methodology is proposed in this paper to explore the influence of physio-environmental factors on dengue incidences. Remotely sensed data provided important data about physical environment and have been used for many vector borne diseases. Information Values (IV method was utilised to derive influence of various factors in the quantitative terms. Researchers have not applied this type of analysis for dengue earlier. Sukhothai province was selected for the case study as it had high number of dengue cases in 1998 and also due to its diverse physical setting with variety of land use/land cover types. Results Preliminary results demonstrated that physical factors derived from remotely sensed data could indicate variation in physical risk factors affecting DF/DHF. A composite analysis of these three factors with dengue incidences was carried out using multivariate regression analysis. Three empirical models ER-1, ER-2 and ER-3 were evaluated. It was found that these three factors have significant relation with DF/DHF incidences and can be related to

  18. Theory of Nova Outbursts and Type Ia Supernovae

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    M. Kato

    2015-02-01

    Full Text Available We briefly review the current theoretical understanding of the light curves of novae. These curves exhibit a homologous nature, dubbed the universal decline law, and when time-normalized, they almost follow a single curve independently of the white dwarf (WD mass or chemical composition of the envelope. The optical and near-infrared light curves of novae are reproduced mainly by free-free emission from their optically thick winds. We can estimate the WD mass from multiwavelength observations because the optical, UV, and soft X-ray light curves evolve differently and we can easily resolve the degeneracy of the optical light curves. Recurrent novae and classical novae are a testbed of type Ia supernova scenarios. In the orbital period versus secondary mass diagram, recurrent novae are located in different regions from classical novae and the positions of recurrent novae are consistent with the single degenerate scenario.

  19. Environmentally-driven ensemble forecasts of dengue fever

    Science.gov (United States)

    Yamana, T. K.; Shaman, J. L.

    2017-12-01

    Dengue fever is a mosquito-borne viral disease prevalent in the tropics and subtropics, with an estimated 2.5 billion people at risk of transmission. In many areas where dengue is found, disease transmission is seasonal but prone to high inter-annual variability with occasional severe epidemics. Predicting and preparing for periods of higher than average transmission remains a significant public health challenge. Recently, we developed a framework for forecasting dengue incidence using an dynamical model of disease transmission coupled with observational data of dengue cases using data-assimilation methods. Here, we investigate the use of environmental data to drive the disease transmission model. We produce retrospective forecasts of the timing and severity of dengue outbreaks, and quantify forecast predictive accuracy.

  20. Urbanização e ecologia do dengue Urbanization and dengue ecology

    Directory of Open Access Journals (Sweden)

    Pedro Luiz Tauil

    2001-01-01

    Full Text Available As mudanças demográficas ocorridas nos países subdesenvolvidos, a partir dos anos 60, geradas por intenso fluxo migratório rural-urbano, resultaram em crescimento desordenado das cidades, nas quais se destacam a carência de facilidades - em particular, de habitação e saneamento básico. Cerca de 20% da população das grandes e médias cidades estão vivendo em favelas, cortiços ou em áreas de invasão. Pela falta de abastecimento de água, há necessidade de armazená-la precariamente, tal como pela ausência de destino adequado do lixo ocorre a proliferação de criadouros potenciais do Aedes aegypti, principal mosquito vetor da dengue, ou seja, depósitos improvisados para água potável e recipientes em que a água é acumulada, constituídos principalmente por latas, plásticos e garrafas usadas. A indústria moderna, por outro lado, privilegia a produção de material descartável. O vírus do dengue tem sua propagação facilitada pela intensidade e freqüência dos meios de transporte, os quais favorecem também a disseminação dos vetores da doença. Estes são alguns dos fatores que tentam explicar o ressurgimento do dengue, a mais importante arbovirose no mundo atualmente e que acomete milhares de pessoas todos os anos.Demographic changes occurring in underdeveloped countries due to intense rural-urban migration since the 1960s have resulted in overcrowded cities with multiple deficiencies, particularly in housing and basic sanitation. Some 20% of the population in large and medium-sized cities live in slums or under similar conditions. Lack of regular water supply and public garbage collection foster the proliferation of potential breeding sites for Aedes aegypti (the main mosquito vector for dengue, including precarious reservoirs for potable water and disposable recipients which accumulate water, like used cans and plastic and glass bottles. Modern industries also produce large volumes of disposable materials. Propagation

  1. Changing haematological parameters in dengue viral infections

    International Nuclear Information System (INIS)

    Jamil, T.; Mehmood, K.; Mujtaba, G.; Choudhry, N.

    2012-01-01

    Background: Dengue Fever is the most common arboviral disease in the world, and presents cyclically in tropical and subtropical regions of the world. The four serotypes of dengue virus, 1, 2, 3, and 4, form an antigenic subgroup of the flaviviruses (Group B arboviruses). Transmission to humans of any of these serotypes initiates a spectrum of host responses, from in apparent to severe and sometimes lethal infections. Complete Blood count (CBC) is an important part of the diagnostic workup of patients. Comparison of various finding in CBC including peripheral smear can help the physician in better management of the patient. Material and Methods: This cross sectional study was carried out on a series of suspected patients of Dengue viral infection reporting in Ittefaq Hospital (Trust). All were investigated for serological markers of acute infection. Results Out of 341 acute cases 166 (48.7%) were confirmed by IgM against Dengue virus. IgG anti-dengue was used on 200 suspected re-infected patients. Seventy-one (39.5%) were positive and 118 (59%) were negative. Among 245 confirmed dengue fever patients 43 (17.6%) were considered having dengue hemorrhagic fever on the basis of lab and clinical findings. Raised haematocrit, Leukopenia with relative Lymphocytosis and presence atypical lymphocytes along with plasmacytoid cells was consistent finding at presentation in both the patterns of disease, i.e., Dengue Haemorrhagic fever (DHF) and Dengue fever (DF). Conclusion: Changes in relative percentage of cells appear with improvement in the symptoms and recovery from the disease. These findings indicate that in the course of the disease, there are major shifts within cellular component of blood. (author)

  2. Pulsed power supply for Nova Upgrade

    International Nuclear Information System (INIS)

    Bacon, J.L.; Kajs, J.P.; Walls, A.; Weldon, W.F.; Zowarka, R.C.

    1992-01-01

    This report describes work carried out at the Center for Electromechanics at The University of Texas at Austin (CEM-UT). A baseline design of the Nova Upgrade has been completed by Lawrence Livermore National Laboratory. The Nova Upgrade is an 18 beamline Nd: glass laser design utilizing fully relayed 4x4 30 cm aperture segmented optical components. The laser thus consists of 288 independent beamlets nominally producing 1.5 to 2.0 MJ of 0.35 μm light in a 3 to 5 ns pulse. The laser design is extremely flexible and will allow a wide range of pulses to irradiate ICF targets. This facility will demonstrate ignition/gain and the scientific feasibility of ICF for energy and defense applications. The pulsed power requirements for the Nova Upgrade are given. CEM-UT was contracted to study and develop a design for a homopolar generator/inductor (HPG/inductor) opening switch system which would satisfy the pulsed power supply requirements of the Nova Upgrade. The Nd:glass laser amplifiers used in the Nova Upgrade will be powered by light from xenon flashlamps. The pulsed power supply for the Nova Upgrade powers the xenon flashlamps. This design and study was for a power supply to drive flashlamps

  3. Dengue: an update on treatment options.

    Science.gov (United States)

    Chan, Candice Y Y; Ooi, Eng Eong

    2015-01-01

    Dengue is the most important mosquito-borne viral pathogen globally, with approximately 100 million cases of acute dengue annually. Infection can result in severe, life-threatening disease. Currently, there is no effective vaccine or licensed antiviral. Management is primarily supportive with fluids. Direct antiviral therapies that reduce dengue severity could be useful although these would need to inhibit all four viral serotypes effectively. This review focuses on the interventions that currently considered the gold standard in case management as well as exploratory therapies that have been studied in clinical trials. Although antiviral drug and therapeutic antibodies for dengue remain a work in progress, these studies have produced some promising results and may have the potential to be future drugs.

  4. System Dynamics based Dengue modeling environment to simulate evolution of Dengue infection under different climate scenarios

    Science.gov (United States)

    Anwar, R.; Khan, R.; Usmani, M.; Colwell, R. R.; Jutla, A.

    2017-12-01

    Vector borne infectious diseases such as Dengue, Zika and Chikungunya remain a public health threat. An estimate of the World Health Organization (WHO) suggests that about 2.5 billion people, representing ca. 40% of human population,are at increased risk of dengue; with more than 100 million infection cases every year. Vector-borne infections cannot be eradicated since disease causing pathogens survive in the environment. Over the last few decades dengue infection has been reported in more than 100 countries and is expanding geographically. Female Ae. Aegypti mosquito, the daytime active and a major vector for dengue virus, is associated with urban population density and regional climatic processes. However, mathematical quantification of relationships on abundance of vectors and climatic processes remain a challenge, particularly in regions where such data are not routinely collected. Here, using system dynamics based feedback mechanism, an algorithm integrating knowledge from entomological, meteorological and epidemiological processes is developed that has potential to provide ensemble simulations on risk of occurrence of dengue infection in human population. Using dataset from satellite remote sensing, the algorithm was calibrated and validated using actual dengue case data of Iquitos, Peru. We will show results on model capabilities in capturing initiation and peak in the observed time series. In addition, results from several simulation scenarios under different climatic conditions will be discussed.

  5. Dengue mortality in Colombia, 1985-2012.

    Science.gov (United States)

    Chaparro-Narváez, Pablo; León-Quevedo, Willian; Castañeda-Orjuela, Carlos Andrés

    2016-02-11

    Dengue in Colombia is an important public health problem due to the huge economic and social costs it has caused, especially during the disease outbreaks.  To describe the behavior of dengue mortality in Colombia between 1985 and 2012.  We conducted a descriptive study. Information was obtained from mortality and population projection databases provided by the Departamento Administrativo Nacional de Estadística (DANE) for the 1985-2012 period. Mortality rates, rate ratios, and case fatality rates were estimated.  A total of 1,990 dengue deaths were registered during this period in Colombia. Dengue mortality rates presented an increasing trend with statistical significance between 1985 and 1998. Higher mortality rates were reported in men both younger than 5 years and older than 65 years. Between 1995 and 2012, category 1 to 4 municipalities reported the highest mortality rates. Case fatality rates varied during the period between 0.01% and 0.39%.  Dengue is an avoidable disease that should disappear from mortality statistics as a cause of death. The event is avoidable if the proposed activities from the Estrategia de Gestión Integrada (EGI)-Dengue are implemented and evaluated. We recommend encouraging the development of an informational culture to contribute to decision making and prioritizing resource allocation.

  6. RECICLAGEM ENERGÉTICA: UMA SOLUÇÃO INOVADORA PARA O PLÁSTICO NÃO RECICLÁVEL

    OpenAIRE

    Silva, Julyane Carolina Julyane C. da; UniBH; Pires, Pedro Henrique Pedro H. Pires; UniBH; de Oliveira, Magno André Magno A. de Oliveira; UniBH; Silva, Thuanye Peixoto Thuanye Peixoto; UniBH

    2011-01-01

    Este trabalho visa mostrar uma nova tecnologia, que já é utilizada em mais de 35 países com mais de 750 usinas no total e que ainda está em estudo no Brasil: a reciclagem energética do plástico. O objetivo é analisar o plástico, sua composição química, as etapas de reciclagem do material e produção de energia, os produtos finais obtidos pela reciclagem e os gases liberados no decorrer do processo. Dessa forma, após evidenciar como esta é uma tecnologia vantajosa, espera-se despertar para a re...

  7. Far Ultraviolet Spectroscopy of Three Long Period Nova-Like Variables, V363 Aur, AC Cnc and RZ Gru

    Science.gov (United States)

    Bisol, Alexandra; Sion, E. M.

    2011-01-01

    We have selected three nova-like variables: V363 Aur, RZ Gru and AC Cnc, all of which are UX UMa types, having similar orbital periods well beyond the 3 to 4 hour range where most nova-likes are found. All should have very similar secondary stars given the fact that they their physical parameters are so similar. V363 Aur is a bona fide SW Sex star, and AC Cnc is a probable one, while RZ Gru is not a member of the SW Sex subclass. Our objective is to carry out the first synthetic spectral analysis of far ultraviolet spectra of the three systems using state-of-the-art models both of accretion disks and photospheres. Therefore we shall compare the distances we obtain from the best fitting synthetic spectral models to other distance estimates in the literature. We present model-derived accretion rates and distances for all three systems. The FUV flux range of RZ Gru and V363 Aur is dominated by radiation from an optically thick, steady state, accretion but for AC Cnc, we find that a hot white dwarf accounts for 70% of the FUV flux. We compare the FUV characteristics and physical properties of these three long period nova-like systems to the properties of other nova-likes at shorter periods. This work was supported in part by NSF grant AST0807892 to Villanova University.

  8. Dengue knowledge in indoor dengue patients from low socioeconomic class; etiology, symptoms, mode of transmission and prevention

    International Nuclear Information System (INIS)

    Shams, N.; Ahmed, W.; Seetlani, N.K.; Farhat, S.

    2018-01-01

    Dengue fever has emerged as an emerging public health issue during last decade bearing significant morbidity and economic burden particularly in third world countries. Current study aims to assess various domains of knowledge of indoor dengue patients. Methods: This descriptive cross-sectional study was conducted at Medicine dept. Rawal Institute of Health Sciences Islamabad and BBH Rawalpindi over 6 months. One hundred and twenty-five adult indoor confirmed cases of dengue from lower socioeconomic class were included after ethical approval. The 25-item dengue knowledge questionnaire including aetiology, symptoms, modes of transmission and prevention of dengue was filled. Results: Among 125 cases (77% males and 23% females), mean age was 30+-13 years. Mean knowledge score was 11+-5 points; with excellent knowledge in 6%, good knowledge (22%), moderate knowledge (23%), fair knowledge (34%) and poor knowledge (17%). Mosquito being a vector of dengue was identified by 78%, with peak time in afternoon (48%). Symptoms identified include fever (95%), headache (55%), muscle pain (44%), rash (33%), retro-orbital pain (32%), joint pains (28%) and abdominal pain (18%). Flies and ticks aren't the vectors of dengue according to 61% and 74% respectively, special mosquito is vector (54%), i.e., Aedes Aegypti (18%) that breeds in standing water (53%). Preventive measures identified were netting (56%), insecticide sprays (54%), covering water containers (38%), removing standing water (36%), mosquito repellents (17%), cutting down bushes (22%) and pouring chemicals in standing water (18%). Conclusion: Our patients from lower socioeconomic class, though aware of vector and mode of transmission, have insufficient knowledge of prevention and vector control measures. There is need to strengthen dengue awareness through community based programs, social media, schools and health care centres for high risk people well before the expected epidemic season about mode of transmission

  9. Dengue viremia in blood donors in Northern India: Challenges of emerging dengue outbreaks to blood transfusion safety

    Directory of Open Access Journals (Sweden)

    Sadhana Mangwana

    2015-01-01

    Full Text Available Backdround: Emerging infectious diseases pose threats to the general human population; including recipients of blood transfusions. Dengue is spreading rapidly to new areas and with increasing frequency of major outbreaks. Screening blood for dengue antigens in dengue-endemic countries would be costly and should, therefore, be recommended only after careful assessment of risk for infection and cost. Aim: A prospective study was conducted to establish the magnitude of the threat that dengue poses to blood safety where it is sporadic with seasonal variations, to quantify risk and to assess that whether screening is feasible and cost-effective. Materials and Methods: Nonstructural protein 1 (NS1 antigen test was done on 1709 donations during dengue outbreak in the months August to November 2013 as an additional test using Bio-Rad Platelia Dengue NS1AG test kit which is one step sandwich format microplate enzyme immunoassay using murine monoclonal antibodies for capture and revelation. Chi-square test was used to find statistical significance. Results and Conclusions: Majority cases were whole blood, replacement, male donors with 76.10% donors in <35 years age group. About 17.85% were single donor platelet donations. NS1 antigen in all donors was negative. In the past, dengue affected mainly children who do not donate blood. With the changing trend, mean age of infection increased affecting the population that does donate blood, further reducing blood donation pool. Further studies need to be done in different geographic regions of the country during dengue transmission season to establish maximum incidence of viremic donations, rates of transfusion transmission and clinical consequences in recipients. If risk is found to be substantial, decision will be taken by the policymakers at what threshold screening should be instituted to ensure safe blood transfusion.

  10. Factors affecting dengue prevention practices: nationwide survey of the Malaysian public.

    Directory of Open Access Journals (Sweden)

    Li Ping Wong

    Full Text Available Efforts to stamp dengue in many dengue endemic countries has met little success. There is a need to re-examine and understand how the public at large view the dengue prevention efforts. This study aimed to examine the demographic factors, theoretical constructs of the Health Belief Model and knowledge about dengue and how these influence the practice of dengue prevention.A national telephone survey was carried out with 2,512 individuals of the Malaysian public aged 18-60 years.The majority (73% of the Malaysian public had a total dengue prevention score of 51-100 (of a possible score of 1-100. Multivariate analysis suggests significant correlates of higher dengue prevention practices with demographic background, perception of susceptibility to dengue, perceived density of mosquitoes in the neighbourhood and knowledge about dengue. Households of lower income of which the majority (40.7% were from the rural areas, were associated with the highest odds [OR = 1.33; 95%CI = 1.09-1.67; p = 0.004] of dengue prevention. Dengue prevention practices were also less likely to be undertaken in neighbourhoods where the responders perceived there is no and/or low density of mosquitoes. Dengue prevention practices are also less likely to be practiced by skilled workers [OR = 0.78; 95%CI = 0.63-0.95; p = 0.029] compared to those unemployed. Higher perceived susceptibility to dengue was associated with higher dengue prevention practices and participants with higher dengue knowledge were found to have a higher level of involvement in dengue prevention practices.Results from the study suggest that in formulating approaches to contain dengue, strategies should be developed to cultivate dengue prevention practices among urban population and target areas with low density of mosquitoes where public perceived a less likely chance of getting dengue. Dengue prevention campaigns should focus on messages highlighting the risk of contracting dengue and education to increase

  11. Developing a Time Series Predictive Model for Dengue in Zhongshan, China Based on Weather and Guangzhou Dengue Surveillance Data.

    Directory of Open Access Journals (Sweden)

    Yingtao Zhang

    2016-02-01

    Full Text Available Dengue is a re-emerging infectious disease of humans, rapidly growing from endemic areas to dengue-free regions due to favorable conditions. In recent decades, Guangzhou has again suffered from several big outbreaks of dengue; as have its neighboring cities. This study aims to examine the impact of dengue epidemics in Guangzhou, China, and to develop a predictive model for Zhongshan based on local weather conditions and Guangzhou dengue surveillance information.We obtained weekly dengue case data from 1st January, 2005 to 31st December, 2014 for Guangzhou and Zhongshan city from the Chinese National Disease Surveillance Reporting System. Meteorological data was collected from the Zhongshan Weather Bureau and demographic data was collected from the Zhongshan Statistical Bureau. A negative binomial regression model with a log link function was used to analyze the relationship between weekly dengue cases in Guangzhou and Zhongshan, controlling for meteorological factors. Cross-correlation functions were applied to identify the time lags of the effect of each weather factor on weekly dengue cases. Models were validated using receiver operating characteristic (ROC curves and k-fold cross-validation.Our results showed that weekly dengue cases in Zhongshan were significantly associated with dengue cases in Guangzhou after the treatment of a 5 weeks prior moving average (Relative Risk (RR = 2.016, 95% Confidence Interval (CI: 1.845-2.203, controlling for weather factors including minimum temperature, relative humidity, and rainfall. ROC curve analysis indicated our forecasting model performed well at different prediction thresholds, with 0.969 area under the receiver operating characteristic curve (AUC for a threshold of 3 cases per week, 0.957 AUC for a threshold of 2 cases per week, and 0.938 AUC for a threshold of 1 case per week. Models established during k-fold cross-validation also had considerable AUC (average 0.938-0.967. The sensitivity and

  12. Developing a Time Series Predictive Model for Dengue in Zhongshan, China Based on Weather and Guangzhou Dengue Surveillance Data.

    Science.gov (United States)

    Zhang, Yingtao; Wang, Tao; Liu, Kangkang; Xia, Yao; Lu, Yi; Jing, Qinlong; Yang, Zhicong; Hu, Wenbiao; Lu, Jiahai

    2016-02-01

    Dengue is a re-emerging infectious disease of humans, rapidly growing from endemic areas to dengue-free regions due to favorable conditions. In recent decades, Guangzhou has again suffered from several big outbreaks of dengue; as have its neighboring cities. This study aims to examine the impact of dengue epidemics in Guangzhou, China, and to develop a predictive model for Zhongshan based on local weather conditions and Guangzhou dengue surveillance information. We obtained weekly dengue case data from 1st January, 2005 to 31st December, 2014 for Guangzhou and Zhongshan city from the Chinese National Disease Surveillance Reporting System. Meteorological data was collected from the Zhongshan Weather Bureau and demographic data was collected from the Zhongshan Statistical Bureau. A negative binomial regression model with a log link function was used to analyze the relationship between weekly dengue cases in Guangzhou and Zhongshan, controlling for meteorological factors. Cross-correlation functions were applied to identify the time lags of the effect of each weather factor on weekly dengue cases. Models were validated using receiver operating characteristic (ROC) curves and k-fold cross-validation. Our results showed that weekly dengue cases in Zhongshan were significantly associated with dengue cases in Guangzhou after the treatment of a 5 weeks prior moving average (Relative Risk (RR) = 2.016, 95% Confidence Interval (CI): 1.845-2.203), controlling for weather factors including minimum temperature, relative humidity, and rainfall. ROC curve analysis indicated our forecasting model performed well at different prediction thresholds, with 0.969 area under the receiver operating characteristic curve (AUC) for a threshold of 3 cases per week, 0.957 AUC for a threshold of 2 cases per week, and 0.938 AUC for a threshold of 1 case per week. Models established during k-fold cross-validation also had considerable AUC (average 0.938-0.967). The sensitivity and specificity

  13. Aedes mosquito salivary immune peptides: boost or block dengue viral infections

    Directory of Open Access Journals (Sweden)

    Natthanej Luplertlop

    2014-02-01

    Full Text Available Dengue virus, one of the most important arthropod-borne viruses, infected to human can severely cause dengue hemorrhagic fever and dengue shock syndrome. There are expected about 50 million dengue infections and 500 000 individuals are hospitalized with dengue hemorrhagic fever, mainly in Southeast Asia, Pacific, and in Americas reported each year. The rapid expansion of global dengue is one of a major public health challenge, together with not yet successful solutions of dengue epidemic control strategies. Thus, these dynamic dengue viral infections exhibited high demographic, societal, and public health infrastructure impacts on human. This review aimed to highlight the current understanding of dengue mosquito immune responses and role of mosquito salivary glands on dengue infection. These information may provide a valuable knowledge of disease pathogenesis, especially in mosquito vector and dengue virus interaction, which may help to control and prevent dengue distribution.

  14. The coexistence of peace and conflict in South America: toward a new conceptualization of types of peace A coexistência entre paz e conflito na América do Sul: em direção a uma nova conceituação dos tipos de paz

    Directory of Open Access Journals (Sweden)

    Jorge Mario Battaglino

    2012-12-01

    Full Text Available South America's predominant democratic regimes and its increasing interdependence on regional trade have not precluded the emergence of militarized crises between Colombia and Venezuela or the revival of boundary claims between Chile and Peru. This way, how can we characterize a zone that, in spite of its flourishing democracy and dense economic ties, remain involved in territorial disputes for whose resolution the use of force has not yet been discarded? This article contends that existing classifications of zones of peace are not adequate to explain this unusual coexistence. Thus, its main purpose is to develop a new analytical category of regional peace for assessing this phenomenon: the hybrid peace. It aims to research the evolution of security systems in South America during the previous century and build a new, threefold classification of peace zones: negative peace zones, hybrid peace zones, and positive peace zones.O fato de os países sul-americanos possuírem regimes predominantemente democráticos e apresentarem uma interdependência cada vez maior não evitou que houvesse tensões militares entre Colômbia e Venezuela ou que ressurgissem conflitos de fronteira entre Chile e Peru. Assim sendo, como se caracterizaria uma região que, apesar do clima democrático crescente e dos densos laços econômicos, permanece imersa em disputas territoriais cuja resolução tem sido frequentemente pensada com referências ao uso da força? Por meio do presente artigo, argumenta-se que as tipologias existentes sobre zonas de paz não são adequadas para explicar essa contradição. Para tanto, o propósito principal do trabalho é desenvolver uma categoria analítica nova de paz regional, a paz híbrida, para analisar esse fenômeno. A intenção é pesquisar a evolução dos sistemas de segurança na América do Sul durante o último século e construir uma nova classificação de zonas de paz em três tipos: zonas de paz negativas, zonas de paz

  15. Mudanças contextuais e as novas regulações: repercussões no campo da política educacional

    Directory of Open Access Journals (Sweden)

    Antônio Cabral Neto

    2012-04-01

    Full Text Available A análise realizada neste artigo tem por objetivo compreender o redesenho assumido pelo processode regulação concebido nas últimas décadas, situando-os no contexto socioeconômicoe político no qual eles são idealizados e ganham materialidade. Para dar concretude a esseobjetivo, o artigo organiza-se em três partes. Na primeira, procura-se delinear as principaismudanças econômicas e políticas que se operaram no padrão de acumulação capitalista nasúltimas décadas do século XX e seus desdobramentos na primeira década do século XXI. Nasegunda parte, discute-se como as mudanças ocorridas nesse cenário (reconfiguram as basesdo processos regulatórios conferindo-lhes novos significados. Na terceira parte discutem-se asrepercussões das novas regulações no campo da educação. As conclusões esboçadas nesteartigo evidenciam que, no jogo das relações globalizadas, os países de maior poder econômicoe político exercem uma hegemonia em todos os campos (econômico, político, cultural,educacional, de modo que os países em desenvolvimento se inserem, de forma subordinada,nessa nova dinâmica. Ocorre uma tendência do fortalecimento de instâncias supranacionaisque procuram criar os ordenamentos jurídicos e políticos para orientar o desenvolvimento docapitalismo nessa nova fase. Constata-se, todavia, que os estados nacionais, mesmo tendoperdido certa autonomia no âmbito da economia globalizada, ainda detêm papel importantena definição de sua agenda política, econômica e educacional. Especificamente na educaçãose verifica uma complexa relação entre as regulações transnacional, nacional e local. Essestrês tipos de regulação se articulam e estão presentes simultaneamente no campo da políticaeducacional. Realça-se, entretanto, que, de fato, em nível local, cada vez mais, se esmaece acapacidade das instituições educacionais no que concerne a sua autonomia para definir normativasque orientem os sistemas de ensino

  16. Retrospective analysis of dengue specific IgM reactive serum samples

    Directory of Open Access Journals (Sweden)

    Nemai Bhattacharya

    2013-04-01

    Full Text Available Objective: To conduct a retrospective analysis of dengue cases in Kolkata, on the basis of presence of anti-dengue IgM in their sera and presence or absence of anti-dengue IgG and dengue specific Non structural 1 (NS1 antigen in each of the serum sample. Methods: Sample was tested quantitatively employing ELISA technique, using Biorad test kits, with a view to get a more comprehensive picture of dengue in an urban endemic area and also to evaluate individual cases. Results: This reconstructed study revealed that of those 91 dengue cases, 70.3% (64 and 29.7% (27 were suffering from secondary and primary dengue respectively, showing that number of secondary dengue cases were much more than that of primary dengue cases with a possibility of emergence of DHF. A small proportion of cases 18.7% (17 were reactive for NS1. The duration of fever in NS1 antigen positive cases varied between 5 and 7 days. Of 17 NS1 reactive cases, 10 (10.9% and 7 (7.7% were suffering from secondary and primary dengue respectively. Conclusions: Early detection of primary and secondary dengue cases would be facilitated by utilizing all three parameters (NS1 antigen, anti-dengue IgM and IgG helping to evaluate, monitor and treat a dengue case effectively.

  17. Assessing changes in knowledge, attitude and practices on dengue diagnosis and management among primary care physicians after the largest dengue epidemic in Singapore.

    Science.gov (United States)

    Pang, Junxiong; Hildon, Zoe Jane-Lara; Thein, Tun Linn; Jin, Jing; Leo, Yee Sin

    2017-06-15

    Dengue results in high morbidity and mortality globally. The knowledge, attitude and practices (KAP) of dengue management, including diagnosis, among primary care physicians (PCPs) are important to reduce dengue transmission and burden. However, there is a lack of understanding on the impact of dengue epidemic on dengue management. Hence, the aim of this study is to examine the changes in KAP on dengue management among PCPs before and after the largest dengue epidemic in 2013 in Singapore. Surveys were mailed to 2000 and 1514 PCPs registered under the Singapore Medical Council in March of year 2011 and 2014, respectively. Survey data were then collected between April and June of that year. Chi-square or Fisher's exact test was used for comparing categorical variables. A multivariate logistic regression model was implemented to determine independent factors for frequent use of dengue diagnostic tests (DDTs). All tests were conducted at 5% level of significance. Adjusted odds ratio and corresponding 95% confidence intervals were reported, where applicable. Qualitative data were descriptively coded for themes and analysis. Among PCPs surveyed in 2011 and 2014, 89.9% and 86% had good knowledge on dengue management respectively. The usage of DDTs had increased significantly in 2014 (N = 164;56%) as compared to 2011 (N = 107;29.5%) in both private and public clinics (p Dengue Duo point-of-care test (POCT) kits was independently associated with frequent use of DDTs (adjusted odds ratio = 2.15; 95% confidence interval = 1.25-3.69). There was a significant reduction in referral of dengue patients to hospital (31.4% in 2011; 13.3% in 2014; p dengue management can be improved with availability of POCT kit, better awareness of the disease and any revised clinical guidelines. The knowledge on dengue management remained high, while the attitude and practices, particularly on the usage of DDTs improved significantly after a large epidemic. Furthermore, PCPs had more

  18. Proposta de uma abordagem psicoeducacional em grupos para pacientes adultos com Transtorno de Déficit de Atenção/Hiperatividade

    OpenAIRE

    Grevet, Eugenio Horácio; Abreu, Paulo Belmonte de; Shansis, Flávio

    2003-01-01

    Os autores do presente artigo propõem, a partir do modelo pedagógico proposto por Antoni Zabala, uma abordagem psicoeducativa grupal para pacientes adultos portadores de Transtorno de Déficit de Atenção/Hiperatividade. Para tanto, adaptam esta estrutura pedagógica para fundamentar a abordagem de grupos psicoeducacionais. O presente trabalho adiciona uma nova técnica para o tratamento do TDAH no adulto a partir da interface entre a pedagogia e a psicoterapia. TIn this paper the authors sugg...

  19. Bossa Nova

    DEFF Research Database (Denmark)

    Petersen, Nicoline Jacoby; Bræstrup, Lise

    "Bossa Nova" giver dig de bedste bud på, hvordan du takler den menneskelige dimension i ledelse. Når du bevæger dig ud på gulvet, opstår der konflikter, kærlighed, jalousi og vrede. Pludselig opdager du, at medarbejdere tænker meget anderledes end dig selv, har forskellige behov og af og til......, kriser og meget andet. Her er værdifulde iagttagelser og tips, som enhver leder ? uanset branche ? kan bruge i sin dagligdag. "Bossa Nova" er uundværlig for den, der vil lære mere om, hvordan man får mennesker til at præstere det sublime, så ledelse bliver en dans, hvor alle kan følge takten....

  20. Dengue in the Americas and Southeast Asia: do they differ? El dengue en las Américas y el sudeste asiático: ¿son diferentes?

    Directory of Open Access Journals (Sweden)

    Scott B. Halstead

    2006-12-01

    Full Text Available The populations of Southeast Asia (SE Asia and tropical America are similar, and all four dengue viruses of Asian origin are endemic in both regions. Yet, during comparable 5-year periods, SE Asia experienced 1.16 million cases of dengue hemorrhagic fever (DHF, principally in children, whereas in the Americas there were 2.8 million dengue fever (DF cases, principally in adults, and only 65 000 DHF cases. This review aims to explain these regional differences. In SE Asia, World War II amplified Aedes aegypti populations and the spread of dengue viruses. In the Americas, efforts to eradicate A. aegypti in the 1940s and 1950s contained dengue epidemics mainly to the Caribbean Basin. Cuba escaped infections with the American genotype dengue-2 and an Asian dengue-3 endemic in the 1960s and 1970s. Successive infections with dengue-1 and an Asian genotype dengue-2 resulted in the 1981 DHF epidemic. When this dengue-2 virus was introduced in other Caribbean countries, it encountered populations highly immune to the American genotype dengue-2. During the 1980s and 1990s, rapidly expanding populations of A. aegypti in Brazil permitted successive epidemics of dengue-1, -2, and -3. These exposures, however, resulted mainly in DF, with surprisingly few cases of DHF. The absence of high rates of severe dengue disease in Brazil, as elsewhere in the Americas, may be partly explained by the widespread prevalence of human dengue resistance genes. Understanding the nature and distribution of these genes holds promise for containing severe dengue. Future research on dengue infections should emphasize population-based designs.Las poblaciones de Asia suroriental y de la América tropical son similares y los cuatro tipos de virus del dengue de origen asiático son endémicos en ambas regiones. Aun así, durante períodos quinquenales comparables ocurrieron 1,16 millones de casos de dengue hemorrágico (DH en Asia suroriental, principalmente en niños, mientras que en

  1. Dengue prediction by the web: Tweets are a useful tool for estimating and forecasting Dengue at country and city level.

    Directory of Open Access Journals (Sweden)

    Cecilia de Almeida Marques-Toledo

    2017-07-01

    Full Text Available Infectious diseases are a leading threat to public health. Accurate and timely monitoring of disease risk and progress can reduce their impact. Mentioning a disease in social networks is correlated with physician visits by patients, and can be used to estimate disease activity. Dengue is the fastest growing mosquito-borne viral disease, with an estimated annual incidence of 390 million infections, of which 96 million manifest clinically. Dengue burden is likely to increase in the future owing to trends toward increased urbanization, scarce water supplies and, possibly, environmental change. The epidemiological dynamic of Dengue is complex and difficult to predict, partly due to costly and slow surveillance systems.In this study, we aimed to quantitatively assess the usefulness of data acquired by Twitter for the early detection and monitoring of Dengue epidemics, both at country and city level at a weekly basis. Here, we evaluated and demonstrated the potential of tweets modeling for Dengue estimation and forecast, in comparison with other available web-based data, Google Trends and Wikipedia access logs. Also, we studied the factors that might influence the goodness-of-fit of the model. We built a simple model based on tweets that was able to 'nowcast', i.e. estimate disease numbers in the same week, but also 'forecast' disease in future weeks. At the country level, tweets are strongly associated with Dengue cases, and can estimate present and future Dengue cases until 8 weeks in advance. At city level, tweets are also useful for estimating Dengue activity. Our model can be applied successfully to small and less developed cities, suggesting a robust construction, even though it may be influenced by the incidence of the disease, the activity of Twitter locally, and social factors, including human development index and internet access.Tweets association with Dengue cases is valuable to assist traditional Dengue surveillance at real-time and low

  2. Dengue prediction by the web: Tweets are a useful tool for estimating and forecasting Dengue at country and city level.

    Science.gov (United States)

    Marques-Toledo, Cecilia de Almeida; Degener, Carolin Marlen; Vinhal, Livia; Coelho, Giovanini; Meira, Wagner; Codeço, Claudia Torres; Teixeira, Mauro Martins

    2017-07-01

    Infectious diseases are a leading threat to public health. Accurate and timely monitoring of disease risk and progress can reduce their impact. Mentioning a disease in social networks is correlated with physician visits by patients, and can be used to estimate disease activity. Dengue is the fastest growing mosquito-borne viral disease, with an estimated annual incidence of 390 million infections, of which 96 million manifest clinically. Dengue burden is likely to increase in the future owing to trends toward increased urbanization, scarce water supplies and, possibly, environmental change. The epidemiological dynamic of Dengue is complex and difficult to predict, partly due to costly and slow surveillance systems. In this study, we aimed to quantitatively assess the usefulness of data acquired by Twitter for the early detection and monitoring of Dengue epidemics, both at country and city level at a weekly basis. Here, we evaluated and demonstrated the potential of tweets modeling for Dengue estimation and forecast, in comparison with other available web-based data, Google Trends and Wikipedia access logs. Also, we studied the factors that might influence the goodness-of-fit of the model. We built a simple model based on tweets that was able to 'nowcast', i.e. estimate disease numbers in the same week, but also 'forecast' disease in future weeks. At the country level, tweets are strongly associated with Dengue cases, and can estimate present and future Dengue cases until 8 weeks in advance. At city level, tweets are also useful for estimating Dengue activity. Our model can be applied successfully to small and less developed cities, suggesting a robust construction, even though it may be influenced by the incidence of the disease, the activity of Twitter locally, and social factors, including human development index and internet access. Tweets association with Dengue cases is valuable to assist traditional Dengue surveillance at real-time and low-cost. Tweets are

  3. Implante transapical de valva aórtica: resultados de uma nova prótese brasileira Transapical aortic valve implantation: results of a brazilian prosthesis

    Directory of Open Access Journals (Sweden)

    Diego Felipe Gaia

    2010-09-01

    Full Text Available OBJETIVO: A troca valvar aórtica é procedimento rotineiro com risco aceitável. Em alguns casos, a mortalidade é elevada, levando à contraindicação do procedimento, apesar dos sintomas. O implante minimamente invasivo transcateter de valva aórtica parece ser uma alternativa, reduzindo a morbi-mortalidade. O objetivo deste estudo foi o desenvolvimento e implante de nova prótese para implante transcateter. MÉTODOS: Após desenvolvimento em animais, uma prótese transcateter, balão-expansível foi utilizada em 14 casos de alto risco. O EuroSCORE médio foi de 43,7%. Quatro pacientes apresentavam disfunção de biopróteses e o restante, estenose aórtica calcificada. Todos os pacientes eram sintomáticos. Os procedimentos foram realizados em ambiente cirúrgico híbrido, sob controle ecocardiográfico e fluoroscópico. Com o uso de minitoracotomia esquerda, as próteses foram implantadas através do ápice ventricular, sob estimulação ventricular de alta frequência ou choque hemorrágico controlado, após valvoplastia aórtica. Foram realizados controles clínicos e ecocardiográficos seriados. RESULTADOS: A correta liberação da prótese foi possível em 13 casos. Uma conversão ocorreu. Não houve mortalidade operatória. O gradiente de pico médio pós-implante foi de 25 mmHg. A fração de ejeção apresentou aumento significativo após o 7º pós-operatório. Insuficiência aórtica residual não significativa esteve presente em 71% dos casos, nenhuma significativa. Não ocorreu complicação vascular periférica. Não houve necessidade de marcapasso definitivo. Um caso de acidente vascular cerebral ocorreu. A mortalidade geral foi de 42%. CONCLUSÃO: O implante transapical de valva aórtica transcateter é um procedimento possível com esta nova prótese. O comportamento hemodinâmico foi satisfatório. São necessários estudos de longo prazo e com maior poder amostral, no intuito de determinar a real eficácia e indicação do

  4. RELAÇÕES DE GÊNERO, INFERTILIDADE E NOVAS TECNOLOGIAS REPRODUTIVAS

    Directory of Open Access Journals (Sweden)

    Rosana Machin Barbosa

    2000-01-01

    Full Text Available O texto aborda as novas tecnologias reprodutivas (NTRs e a infertilidade através da experiência de mulheres e homens que buscaram uma gestação por meio dessas técnicas. Os relatos apresentados estão baseados em pesquisa realizada, durante o ano de 1998, em dois serviços voltados ao tratamento de situações de infertilidade: um público — Hospital Pérola Byington, em São Paulo, e outro privado — Cenafert (Centro de Endoscopia e Assistência à Fertilidade, em Brasília/DF. As NTRs são enfocadas no âmbito da tecnologia, da saúde reprodutiva e das relações entre os gêneros.

  5. Therapeutic antibodies as a treatment option for dengue fever.

    Science.gov (United States)

    Chan, Kuan Rong; Ong, Eugenia Z; Ooi, Eng Eong

    2013-11-01

    Dengue fever is the most prevalent mosquito-borne viral disease globally with about 100 million cases of acute dengue annually. Severe dengue infection can result in a life-threatening illness. In the absence of either a licensed vaccine or antiviral drug against dengue, therapeutic antibodies that neutralize dengue virus (DENV) may serve as an effective medical countermeasure against severe dengue. However, therapeutic antibodies would need to effectively neutralize all four DENV serotypes. It must not induce antibody-dependent enhancement of DENV infection in monocytes/macrophages through Fc gamma receptor (FcγR)-mediated phagocytosis, which is hypothesized to increase the risk of severe dengue. Here, we review the strategies and technologies that can be adopted to develop antibodies for therapeutic applications. We also discuss the mechanism of antibody neutralization in the cells targeted by DENV that express Fc gamma receptor. These studies have provided significant insight toward the use of therapeutic antibodies as a potentially promising bulwark against dengue.

  6. Dengue Outbreak in Hadramout, Yemen, 2010: An Epidemiological Perspective

    Science.gov (United States)

    Ghouth, Abdulla Salim Bin; Amarasinghe, Ananda; Letson, G. William

    2012-01-01

    We analyzed surveillance data of a dengue outbreak (2010) reported to the Hadramout Health Office (Yemen) and retrospectively analyzed dengue-related epidemiological and entomological events reported in Hadramout from 2005 to 2009. A total of 630 immunoglobulin M (IgM) -confirmed dengue cases of 982 febrile cases was reported during the period from February to June of 2010; 12 cases died, giving case fatality a rate of 1.9%. Among febrile cases, the highest proportion of dengue cases (37.3%) was reported in the 15- to 24-year-old age group. The overall attack rate was 0.89/1,000. The average number of cases reported by month over the preceding 5-year period compared with the 2010 data is consistent with endemicity of dengue in the region and supports epidemic designation for the dengue activity in 2010. Recognition of endemic dengue transmission and potential for substantial dengue epidemics highlight the need for consistent laboratory-based surveillance that can support prevention and control activities accordingly. PMID:22665621

  7. Absolute spectrophotometry of Nova Cygni 1975

    International Nuclear Information System (INIS)

    Kontizas, E.; Kontizas, M.; Smyth, M.J.

    1976-01-01

    Radiometric photoelectric spectrophotometry of Nova Cygni 1975 was carried out on 1975 August 31, September 2, 3. α Lyr was used as reference star and its absolute spectral energy distribution was used to reduce the spectrophotometry of the nova to absolute units. Emission strengths of Hα, Hβ, Hγ (in W cm -2 ) were derived. The Balmer decrement Hα:Hβ:Hγ was compared with theory, and found to deviate less than had been reported for an earlier nova. (author)

  8. Dengue infection and miscarriage: a prospective case control study.

    Directory of Open Access Journals (Sweden)

    Peng Chiong Tan

    Full Text Available BACKGROUND: Dengue is the most prevalent mosquito borne infection worldwide. Vertical transmissions after maternal dengue infection to the fetus and pregnancy losses in relation to dengue illness have been reported. The relationship of dengue to miscarriage is not known. METHOD: We aimed to establish the relationship of recent dengue infection and miscarriage. Women who presented with miscarriage (up to 22 weeks gestation to our hospital were approached to participate in the study. For each case of miscarriage, we recruited 3 controls with viable pregnancies at a similar gestation. A brief questionnaire on recent febrile illness and prior dengue infection was answered. Blood was drawn from participants, processed and the frozen serum was stored. Stored sera were thawed and then tested in batches with dengue specific IgM capture ELISA, dengue non-structural protein 1 (NS1 antigen and dengue specific IgG ELISA tests. Controls remained in the analysis if their pregnancies continued beyond 22 weeks gestation. Tests were run on 116 case and 341 control sera. One case (a misdiagnosed viable early pregnancy plus 45 controls (39 lost to follow up and six subsequent late miscarriages were excluded from analysis. FINDINGS: Dengue specific IgM or dengue NS1 antigen (indicating recent dengue infection was positive in 6/115 (5·2% cases and 5/296 (1·7% controls RR 3·1 (95% CI 1·0-10 P = 0·047. Maternal age, gestational age, parity and ethnicity were dissimilar between cases and controls. After adjustments for these factors, recent dengue infection remained significantly more frequently detected in cases than controls (AOR 4·2 95% CI 1·2-14 P = 0·023. INTERPRETATION: Recent dengue infections were more frequently detected in women presenting with miscarriage than in controls whose pregnancies were viable. After adjustments for confounders, the positive association remained.

  9. Novas relações entre estado e sociedade civil no âmbito da habitação: um estudo de caso

    Directory of Open Access Journals (Sweden)

    Adriana Andrela Camponez

    2004-12-01

    Full Text Available Observa-se no cenário brasileiro dos anos 90 a redefinição das relações entre Estado e sociedade civil no encaminhamento das políticas públicas. O Projeto Casa Fácil-Convênio de Moradia Popular é um exemplo dessa nova perspectiva. Desenvolvido pelo Clube de Engenharia e Arquitetura de Londrina, é uma forma alternativa de política pública não-governamental no campo da habitação. Este artigo analisa a experiência do Projeto Casa Fácil como exemplo desta nova relação, enfatizando os interesses que permeiam a relação de parceria entre a prefeitura local e o Clube de Engenharia no atendimento das demandas populares do setor habitacional.

  10. Research on Climate and Dengue in Malaysia: A Systematic Review.

    Science.gov (United States)

    Hii, Yien Ling; Zaki, Rafdzah Ahmad; Aghamohammadi, Nasrin; Rocklöv, Joacim

    2016-03-01

    Dengue is a climate-sensitive infectious disease. Climate-based dengue early warning may be a simple, low-cost, and effective tool for enhancing surveillance and control. Scientific studies on climate and dengue in local context form the basis for advancing the development of a climate-based early warning system. This study aims to review the current status of scientific studies in climate and dengue and the prospect or challenges of such research on a climate-based dengue early warning system in a dengue-endemic country, taking Malaysia as a case study. We reviewed the relationship between climate and dengue derived from statistical modeling, laboratory tests, and field studies. We searched electronic databases including PubMed, Scopus, EBSCO (MEDLINE), Web of Science, and the World Health Organization publications, and assessed climate factors and their influence on dengue cases, mosquitoes, and virus and recent development in the field of climate and dengue. Few studies in Malaysia have emphasized the relationship between climate and dengue. Climatic factors such as temperature, rainfall, and humidity are associated with dengue; however, these relationships were not consistent. Climate change projections for Malaysia show a mounting risk for dengue in the future. Scientific studies on climate and dengue enhance dengue surveillance in the long run. It is essential for institutions in Malaysia to promote research on climate and vector-borne diseases to advance the development of climate-based early warning systems. Together, effective strategies that improve existing research capacity, maximize the use of limited resources, and promote local-international partnership are crucial for sustaining research on climate and health.

  11. Controle no trabalho: uma reflexão sobre antigas e novas formas de controle e suas conseqüências sobre os trabalhadores Control of work: old and new approaches and effects on workers

    Directory of Open Access Journals (Sweden)

    Magali Costa Guimarães

    2006-03-01

    Full Text Available O controle no trabalho tem se constituído em tema de estudo e foco de preocupação por parte de pesquisadores ligados a diferentes áreas do conhecimento (administração, ergonomia, engenharia, psicologia, medicina, etc.. Trata-se de um assunto nuclear, principalmente quando se pensa na centralidade do trabalho nos dias atuais e na sua importância para a construção da identidade. As transformações ocorridas no mundo do trabalho apontam para novas formas de controle, que afetam os indivíduos em seu bem-estar físico, cognitivo e afetivo. É com base nesses pressupostos que este artigo tem como objetivo realizar uma reflexão sobre as diferentes formas de controle presentes no contexto organizacional, por meio de uma análise histórica, buscando compreender o surgimento e evolução do controle no processo de produção, bem como de uma revisão de pesquisas que apontam as conseqüências da perda ou ausência de controle no trabalho. Parte-se, assim, de uma revisão teórico-conceitual para, num segundo momento, apresentar os resultados desses estudos.Control of work has been the subject of study and concern by researchers in areas such as administration, ergonomics, engineering, psychology and medicine. It is a core issue especially in view of the central importance of work today and it's role in building identity. Transformations in the working world point to new forms of control affecting the individual and his physical, cognitive and affective well being. Different forms of control present in the organizational context were analyzed historically. An understanding of the appearance and evolution of control in the production process was sought as well as evidence of the consequences of a loss or absence of control of work. These results were presented after an initial theoretical and conceptual review.

  12. Igreja Matriz de Nossa Senhora dos Remédios, Quevedos, RS: Uma Reflexão Patrimonial

    Directory of Open Access Journals (Sweden)

    Natália Lampert Batista

    2016-12-01

    Full Text Available Interpretar e valorar os elementos de uma paisagem perpassa pela capacidade que tem o receptor de organizar mentalmente sua percepção do local, bem como com o seu conhecimento sobre a história dos elementos que a constituem. No município de Quevedos, observa-se uma fraca percepção da necessidade de preservar o passado e as memórias coletivas do lugar. Partindo dessas premissas, o presente trabalho objetiva realizar uma leitura, sob o enfoque patrimonial, frente à antiga Igreja Matriz de Nossa Senhora dos Remédios, que foi destruída para dar espaço a uma nova Igreja, mais moderna e mais ampla. A metodologia foi embasada na revisão bibliográfica e na perspectiva da pesquisa qualitativa, de caráter empírico por meio da observação direta e participante, por registro visual, fotográfico e de depoimentos. Constatou-se que, mesmo com a existência de uma rica memória individual e coletiva em Quevedos, não há uma valoração dos elementos constitutivos para paisagem local.

  13. Community beliefs and practices about dengue in Puerto Rico Creencias y prácticas comunitarias relacionadas con el dengue en Puerto Rico

    Directory of Open Access Journals (Sweden)

    Carmen L. Pérez-Guerra

    2009-03-01

    Full Text Available OBJECTIVE: In spite of long-term endemicity and repeated government and private efforts, effective, sustained community participation for dengue prevention remains a challenge in Puerto Rico. This study explored differences found in interviews conducted in 2001 in attitudes toward dengue and its prevention by respondents' gender and whether they had a prior dengue infection. Findings may be used to develop messages to promote Aedes aegypti control practices. METHODS: From September to October 2003, 11 focus groups were conducted in San Juan, Puerto Rico. Fifty-nine persons (35 women, 24 men, > 18 years of age, who had been identified through the Puerto Rico dengue surveillance system participated in the focus groups. Analysis was based on grounded theory. RESULTS: Women considered dengue important because of its economic, emotional, and health impact, and they were concerned more often than men about insufficient garbage removal and water disposal. Participants with a previous dengue diagnosis were more concerned about risk of the disease, were more knowledgeable about dengue and its prevention, and recommended use of repellents more often than their counterparts without a previous dengue diagnosis. Barriers to sustained dengue prevention included misconceptions from outdated educational materials, " invisibility" of dengue compared with chronic diseases, and lack of acceptance of responsibility for dengue prevention. CONCLUSION: Suggested strategies to motivate residents' actions included working with government agencies to address structural problems that increase mosquito populations, improving access to information on garbage collection and water disposal through telephone hotlines, increasing publicity and information about dengue by mass media campaigns, and educating health professionals.OBJETIVO: A pesar de la prolongada endemia y los reiterados esfuerzos gubernamentales y privados, la participación efectiva y sostenida de la comunidad

  14. Relative Contribution of Dengue IgG Antibodies Acquired during Gestation or Breastfeeding in Mediating Dengue Disease Enhancement and Protection in Type I Interferon Receptor-Deficient Mice.

    Directory of Open Access Journals (Sweden)

    Pei Xuan Lee

    2016-06-01

    Full Text Available Dengue virus (DENV causes a spectrum of diseases ranging from self-limiting dengue fever to severe conditions such as haemorrhagic fever and dengue shock syndrome. Antibody-dependent enhancement (ADE is thought to explain the occurrence of severe dengue whereby pre-existing binding but non-neutralising antibodies enhance DENV infection. The ADE phenomenon is supported by epidemiological findings that infants that born to dengue immune mothers are at greater risk to develop severe dengue upon primary infection. The role of maternally acquired dengue-specific antibodies in disease enhancement was recently recapitulated in a mouse model where mice born to DENV1-immune mothers experienced enhanced disease severity upon DENV2 infection. Here, this study investigates the relative contribution of maternal dengue-specific antibodies acquired during gestation and breastfeeding in dengue disease. Using a surrogate breastfeeding mother experimental approach, we showed that majority of the maternal dengue-specific antibodies were acquired during breastfeeding and conferred an extended enhancement window. On the other hand, in the context of homologous infection, breastfeeding conferred protection. Furthermore, measurement of dengue-specific antibody titres over time in mice born to dengue immune mothers revealed a biphasic pattern of antibody decay as reported in humans. Our work provides evidence of the potential contribution of breast milk-acquired dengue-specific IgG antibodies in enhancement and protection against dengue. Should such contribution be established in humans as well, it may have important implications for the development of guidelines to dengue-immune breastfeeding mothers.

  15. Relative Contribution of Dengue IgG Antibodies Acquired during Gestation or Breastfeeding in Mediating Dengue Disease Enhancement and Protection in Type I Interferon Receptor-Deficient Mice.

    Science.gov (United States)

    Lee, Pei Xuan; Ong, Li Ching; Libau, Eshele Anak; Alonso, Sylvie

    2016-06-01

    Dengue virus (DENV) causes a spectrum of diseases ranging from self-limiting dengue fever to severe conditions such as haemorrhagic fever and dengue shock syndrome. Antibody-dependent enhancement (ADE) is thought to explain the occurrence of severe dengue whereby pre-existing binding but non-neutralising antibodies enhance DENV infection. The ADE phenomenon is supported by epidemiological findings that infants that born to dengue immune mothers are at greater risk to develop severe dengue upon primary infection. The role of maternally acquired dengue-specific antibodies in disease enhancement was recently recapitulated in a mouse model where mice born to DENV1-immune mothers experienced enhanced disease severity upon DENV2 infection. Here, this study investigates the relative contribution of maternal dengue-specific antibodies acquired during gestation and breastfeeding in dengue disease. Using a surrogate breastfeeding mother experimental approach, we showed that majority of the maternal dengue-specific antibodies were acquired during breastfeeding and conferred an extended enhancement window. On the other hand, in the context of homologous infection, breastfeeding conferred protection. Furthermore, measurement of dengue-specific antibody titres over time in mice born to dengue immune mothers revealed a biphasic pattern of antibody decay as reported in humans. Our work provides evidence of the potential contribution of breast milk-acquired dengue-specific IgG antibodies in enhancement and protection against dengue. Should such contribution be established in humans as well, it may have important implications for the development of guidelines to dengue-immune breastfeeding mothers.

  16. Relative Contribution of Dengue IgG Antibodies Acquired during Gestation or Breastfeeding in Mediating Dengue Disease Enhancement and Protection in Type I Interferon Receptor-Deficient Mice

    Science.gov (United States)

    Lee, Pei Xuan; Ong, Li Ching; Libau, Eshele Anak; Alonso, Sylvie

    2016-01-01

    Dengue virus (DENV) causes a spectrum of diseases ranging from self-limiting dengue fever to severe conditions such as haemorrhagic fever and dengue shock syndrome. Antibody-dependent enhancement (ADE) is thought to explain the occurrence of severe dengue whereby pre-existing binding but non-neutralising antibodies enhance DENV infection. The ADE phenomenon is supported by epidemiological findings that infants that born to dengue immune mothers are at greater risk to develop severe dengue upon primary infection. The role of maternally acquired dengue-specific antibodies in disease enhancement was recently recapitulated in a mouse model where mice born to DENV1-immune mothers experienced enhanced disease severity upon DENV2 infection. Here, this study investigates the relative contribution of maternal dengue-specific antibodies acquired during gestation and breastfeeding in dengue disease. Using a surrogate breastfeeding mother experimental approach, we showed that majority of the maternal dengue-specific antibodies were acquired during breastfeeding and conferred an extended enhancement window. On the other hand, in the context of homologous infection, breastfeeding conferred protection. Furthermore, measurement of dengue-specific antibody titres over time in mice born to dengue immune mothers revealed a biphasic pattern of antibody decay as reported in humans. Our work provides evidence of the potential contribution of breast milk-acquired dengue-specific IgG antibodies in enhancement and protection against dengue. Should such contribution be established in humans as well, it may have important implications for the development of guidelines to dengue-immune breastfeeding mothers. PMID:27341339

  17. Molecular surveillance of dengue in Semarang, Indonesia revealed the circulation of an old genotype of dengue virus serotype-1.

    Directory of Open Access Journals (Sweden)

    Sukmal Fahri

    Full Text Available Dengue disease is currently a major health problem in Indonesia and affects all provinces in the country, including Semarang Municipality, Central Java province. While dengue is endemic in this region, only limited data on the disease epidemiology is available. To understand the dynamics of dengue in Semarang, we conducted clinical, virological, and demographical surveillance of dengue in Semarang and its surrounding regions in 2012. Dengue cases were detected in both urban and rural areas located in various geographical features, including the coastal and highland areas. During an eight months' study, a total of 120 febrile patients were recruited, of which 66 were serologically confirmed for dengue infection using IgG/IgM ELISA and/or NS1 tests. The cases occurred both in dry and wet seasons. Majority of patients were under 10 years old. Most patients were diagnosed as dengue hemorrhagic fever, followed by dengue shock syndrome and dengue fever. Serotyping was performed in 31 patients, and we observed the co-circulation of all four dengue virus (DENV serotypes. When the serotypes were correlated with the severity of the disease, no direct correlation was observed. Phylogenetic analysis of DENV based on Envelope gene sequence revealed the circulation of DENV-2 Cosmopolitan genotype and DENV-3 Genotype I. A striking finding was observed for DENV-1, in which we found the co-circulation of Genotype I with an old Genotype II. The Genotype II was represented by a virus strain that has a very slow mutation rate and is very closely related to the DENV strain from Thailand, isolated in 1964 and never reported in other countries in the last three decades. Moreover, this virus was discovered in a cool highland area with an elevation of 1,001 meters above the sea level. The discovery of this old DENV strain may suggest the silent circulation of old virus strains in Indonesia.

  18. NOVA Corporation of Alberta annual report, 1992

    International Nuclear Information System (INIS)

    1993-01-01

    Nova Corporation and its related businesses are involved in natural gas production, gas pipelines, consulting services, and upgrading of natural gas into chemicals and plastics. Nova owns Alberta Gas Transmission Division, the primary gas transportation system in Alberta, with 11,400 miles of pipeline and total deliveries in 1992 of 3.4 trillion ft 3 . Nova also owns 50% of Foothills Pipe Lines Ltd., one of Canada's largest carriers of exported gas, and 50% of TQM Pipeline Partnership, which transports natural gas in Quebec. Nova conducts its chemicals business through Novacor Chemicals Ltd., which has plants in Alberta, Ontario, Quebec, and the USA. Novacor's major petrochemicals are methanol, ethylene, propylene, and styrene and its major plastics are polystyrene, polypropylene, and polyethylene. Nova's gas-producing branch Novalta Resources produced 26 billion ft 3 of natural gas in 1992 and has proven reserves of 334 billion ft 3 . Nova's net income in 1992 was $164 million, compared to only $46 million in 1991. The company's operations, along with management discussion and analysis, are presented for 1992 and financial statements are included. 20 figs., 43 tabs

  19. Uma ponte para a especulação: ou a arte da renda na montagem de uma "cidade global"

    Directory of Open Access Journals (Sweden)

    Mariana Fix

    Full Text Available Este artigo analisa conflitos e articulações por trás da transformação de uma antiga área alagadiça, as várzeas do rio Pinheiros, em uma das regiões mais valorizadas de São Paulo e, atualmente, sua fachada globalizada. O texto discute, particularmente, os nexos que se constituem, nas últimas décadas, entre a financeirização global da economia e os arranjos específicos que se configuram em São Paulo; entre mecanismos supostamente avançados - como operações urbanas, Cepacs e fundos de investimento imobiliário - e formas típicas de acumulação primitiva, nas quais força, fraude, opressão e pilhagem são exibidas de modo recorrente; entre "a cidade própria" das elites e a cidade dita clandestina, que ocupa beiras de córrego, encostas de morros, margens de represas. Tomo como referência três ícones dessa paisagem urbana: uma ponte estaiada, imagem-síntese da cenografia da "nova cidade"; um gigantesco emprendimento murado, que mescla residência, comércio de luxo e escritórios; e um complexo empresarial com torres de escritório e hotel, interligados por um shopping subterrâneo.

  20. Análise de um sistema de captura de energia piezoelétrico não linear e não ideal utilizando-se uma estrutura aporticada.

    OpenAIRE

    Itamar Iliuk

    2016-01-01

    A crescente utilização de novas tecnologias, as quais necessitam de uma fonte de energia menor e mais eficiente, como os microssensores para monitoramento de sistemas e estruturas nas chamadas cidades inteligentes, torna a captura da energia do ambiente uma opção viável para alimentação de tais dispositivos. Como a energia cinética é uma fonte de energia facilmente encontrada no ambiente, os sistemas que a capturam e convertem em eletricidade têm sido amplamente estudados, especialmente os qu...

  1. A Hubble Space Telescope survey for novae in M87 - III. Are novae good standard candles 15 d after maximum brightness?

    Science.gov (United States)

    Shara, Michael M.; Doyle, Trisha F.; Pagnotta, Ashley; Garland, James T.; Lauer, Tod R.; Zurek, David; Baltz, Edward A.; Goerl, Ariel; Kovetz, Attay; Machac, Tamara; Madrid, Juan P.; Mikołajewska, Joanna; Neill, J. D.; Prialnik, Dina; Welch, D. L.; Yaron, Ofer

    2018-02-01

    Ten weeks of daily imaging of the giant elliptical galaxy M87 with the Hubble Space Telescope (HST) has yielded 41 nova light curves of unprecedented quality for extragalactic cataclysmic variables. We have recently used these light curves to demonstrate that the observational scatter in the so-called maximum-magnitude rate of decline (MMRD) relation for classical novae is so large as to render the nova-MMRD useless as a standard candle. Here, we demonstrate that a modified Buscombe-de Vaucouleurs hypothesis, namely that novae with decline times t2 > 10 d converge to nearly the same absolute magnitude about two weeks after maximum light in a giant elliptical galaxy, is supported by our M87 nova data. For 13 novae with daily sampled light curves, well determined times of maximum light in both the F606W and F814W filters, and decline times t2 > 10 d we find that M87 novae display M606W,15 = -6.37 ± 0.46 and M814W,15 = -6.11 ± 0.43. If very fast novae with decline times t2 < 10 d are excluded, the distances to novae in elliptical galaxies with stellar binary populations similar to those of M87 should be determinable with 1σ accuracies of ± 20 per cent with the above calibrations.

  2. Investigational drugs in early development for treating dengue infection.

    Science.gov (United States)

    Beesetti, Hemalatha; Khanna, Navin; Swaminathan, Sathyamangalam

    2016-09-01

    Dengue has emerged as the most significant arboviral disease of the current century. A drug for dengue is an urgent unmet need. As conventional drug discovery efforts have not produced any promising clinical candidates, there is a shift toward re-positioning pre-existing drugs for dengue to fast-track dengue drug development. This article provides an update on the current status of recently completed and ongoing dengue drug trials. All dengue drug trials described in this article were identified from a list of >230 trials that were returned upon searching the World Health Organization's International Clinical Trials Registry Platform web portal using the search term 'dengue' on December 31(st), 2015. None of the handful of drugs tested so far has yielded encouraging results. Early trial experience has served to emphasize the challenge of drug testing in the short therapeutic time window available, the need for tools to predict 'high-risk' patients early on and the limitations of the existing pre-clinical model systems. Significant investment of efforts and resources is a must before the availability of a safe, effective and inexpensive dengue drug becomes a reality. Currently, supportive fluid therapy remains the only option available for dengue treatment.

  3. Identidade: do conceito ao produto final - criação e desenvolvimento de uma coleção de jóias através do acto criativo e artístico

    OpenAIRE

    Dalloz, Diogo

    2015-01-01

    O trabalho de investigação proposto teve como objetivo, o desenvolvimento de uma coleção de joias com uma vertente comercial, destinada a um determinado segmento de mercado. Este trabalho busca suprir a escassez de projetos de investigação direcionados para a área comercial do setor, procurando novas possibilidades para o desenvolvimento de coleções de joias através de pequenas e médias empresas. Para isso, foi proposto o desenvolvimento de uma coleção, a partir de uma pequena mostra de joias...

  4. Next-Generation Dengue Vaccines: Novel Strategies Currently Under Development

    OpenAIRE

    Anna P. Durbin; Stephen S. Whitehead

    2011-01-01

    Dengue has become the most important arboviral infection worldwide with more than 30 million cases of dengue fever estimated to occur each year. The need for a dengue vaccine is great and several live attenuated dengue candidate vaccines are proceeding through clinical evaluation. The need to induce a balanced immune response against all four DENV serotypes with a single vaccine has been a challenge for dengue vaccine developers. A live attenuated DENV chimeric vaccine produced by Sanofi Past...

  5. Indices of anti-dengue immunoglobulin G subclasses in adult Mexican patients with febrile and hemorrhagic dengue in the acute phase.

    Science.gov (United States)

    Posadas-Mondragón, Araceli; Aguilar-Faisal, José Leopoldo; Chávez-Negrete, Adolfo; Guillén-Salomón, Edith; Alcántara-Farfán, Verónica; Luna-Rojas, Lucero; Ávila-Trejo, Amanda Marineth; Del Carmen Pacheco-Yépez, Judith

    2017-10-01

    Heterologous secondary infections are at increased risk of developing dengue hemorrhagic fever (DHF) because of antibody-dependent enhancement (ADE). IgG subclasses can fix and activate complement and bind to Fcɣ receptors. These factors may also play an important role in the development of ADE and thus in the pathogenesis of DHF. The aim of this study was to analyze the indices of anti-dengue IgG subclasses in adult patients with febrile and hemorrhagic dengue in the acute phase. In 2013, 129 patients with dengue fever (DF) and 57 with DHF in Veracruz, Mexico were recruited for this study and anti-dengue IgM and IgG determined by capture ELISA. Anti-dengue IgG subclasses were detected by indirect ELISA. Anti-dengue IgG2 and IgG3 subclasses were detected in patients with dengue. IgG1 increased significantly in the sera of patients with both primary and secondary infections and DHF, but was higher in patients with secondary infections. The IgG4 subclass index was significantly higher in the sera of patients with DHF than in that of those with DF, who were in the early and late acute phase of both primary and secondary infection. In conclusion, indices of subclasses IgG1 and IgG4 were higher in patients with DHF. © 2017 The Societies and John Wiley & Sons Australia, Ltd.

  6. Dengue Knowledge and Preventive Practices in Iquitos, Peru.

    Science.gov (United States)

    Paz-Soldán, Valerie A; Morrison, Amy C; Cordova Lopez, Jhonny J; Lenhart, Audrey; Scott, Thomas W; Elder, John P; Sihuincha, Moises; Kochel, Tadeusz J; Halsey, Eric S; Astete, Helvio; McCall, Philip J

    2015-12-01

    As part of a cluster-randomized trial to evaluate insecticide-treated curtains for dengue prevention in Iquitos, Peru, we surveyed 1,333 study participants to examine knowledge and reported practices associated with dengue and its prevention. Entomological data from 1,133 of these households were linked to the survey. Most participants knew that dengue was transmitted by mosquito bite (85.6%), but only few (18.6%) knew that dengue vectors bite during daytime. Most commonly recognized dengue symptoms were fever (86.6%), headache (76.4%), and muscle/joint pain (67.9%). Most commonly reported correct practices for mosquito control were cleaning homes (61.6%), using insecticide sprays (23%), and avoiding having standing water at home (12.3%). Higher education was associated with higher knowledge about dengue, including transmission and vector control. Higher socioeconomic status was associated with increased reported use of preventive practices requiring money expenditure. We were less likely to find Aedes aegypti eggs, larvae, or pupae in households that had dengue has been transmitted in Iquitos since the 1990s and the Regional Health Authority routinely fumigates households, treats domestic water containers with larvicide, and issues health education messages through mass media, knowledge of dengue transmission and household practices for prevention could be improved. © The American Society of Tropical Medicine and Hygiene.

  7. Photometry and polarimetry of Nova Andromedae 1986

    Energy Technology Data Exchange (ETDEWEB)

    Kikuchi, Sen; Mikami, Yoshitaka; Kondo, Masayuki

    1988-01-01

    We have carried out photometry of Nova Andromedae 1986 and find that it should be classified as a fast nova. We have also made polarimetry simultaneously at six wavelengths between 0.36-0.70 ..mu..m. The polarization increased between 2 and 22 days after the light maximum showing that dust formation was associated with the nova explosion.

  8. MORBIMORTALIDADE DA DENGUE EM IDOSOS NO BRASIL - DENGUE MORBIDITY AND MORTALITY IN ELDERLY IN BRAZIL

    Directory of Open Access Journals (Sweden)

    Annah Rachel Graciano

    2017-07-01

    Full Text Available Objective: To determine the prevalence and specific dengue coefficients of mortality in Brazil in the elderly population correlating the rates by male and female. Methods: Analytical ecological study with temporal trend of design. It was used as data sources Sistema de Informação Hospitalar, Sistema de Informação de Mortalidade and Instituto Brasileiro de Geografia e Estatística. The population corresponded to the elderly aged between 60 years to 100 attended at Brazilian public health system whom were diagnosed with dengue between 2008 and 2015. Results: The prevalence rates did not change in the general population between the years 2008 and 2015. There was a significant increase in the number of deaths from dengue. In the elderly group, the prevalence increased substantially, and the specific mortality analysis in this group showed higher values than the mortality of the general population affected by dengue. Conclusions: It is very important to underline studies on the involvement of dengue in elderly groups for the development of public politics and the creation of specific protocols for the diagnosis and treatment in that age group, considering the lack of scientific evidence to entail proper conduct in handling such patients

  9. Clinical profile and warning sign finding in children with severe dengue and non-severe dengue

    Science.gov (United States)

    Adam, A. S.; Pasaribu, S.; Wijaya, H.; Pasaribu, A. P.

    2018-03-01

    Dengue fever is one of the most important emerging vector-borne viral diseases. Approximately 500,000 out of 100 million cases develop to severe dengue infection. Patient with severe dengue (SD) can be predicted by clinical profile, laboratory and warning sign which could be saved by early interventions.This was a retrospective descriptive-analytic study to investigate clinical manifestations, laboratory and warning signs ofchildren with dengue infection in Haji Adam Malik hospital during January 2014–May 2016. Through medical records, we had selected 140 cases which fulfilled research criteria.Cases were classified as SD (n=28) and NSD (n=112). Most common clinical manifestations for NSD were abdominal pain (39.3%), myalgia (39.3%), headache (37.1%), mucosal bleeding (36.4%) while for SD were shock (15.7%), mucosal bleeding (15.7%), clinical fluid accumulation (15%), shortness of breath (14.3%). SGPT >1000IU/L (5 cases), SGOT >1000IU/L (9 cases), PT (10 cases) and aPTT (16 cases) were abnormal in SD. Severe dengue was frequently found in the range of white cell count 1000-4000/L and platelet count 20,000-50,000mm/uL. Clinical manifestations, warning sign, and laboratoryfinding, were different between SD and NSD.

  10. Current Status of Dengue Therapeutics Research and Development.

    Science.gov (United States)

    Low, Jenny G H; Ooi, Eng Eong; Vasudevan, Subhash G

    2017-03-01

    Dengue is a significant global health problem. Even though a vaccine against dengue is now available, which is a notable achievement, its long-term protective efficacy against each of the 4 dengue virus serotypes remains to be definitively determined. Consequently, drugs directed at the viral targets or critical host mechanisms that can be used safely as prophylaxis or treatment to effectively ameliorate disease or reduce disease severity and fatalities are still needed to reduce the burden of dengue. This review will provide a brief account of the status of therapeutics research and development for dengue. © The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America.

  11. Multi-level analyses of spatial and temporal determinants for dengue infection.

    Science.gov (United States)

    Vanwambeke, Sophie O; van Benthem, Birgit H B; Khantikul, Nardlada; Burghoorn-Maas, Chantal; Panart, Kamolwan; Oskam, Linda; Lambin, Eric F; Somboon, Pradya

    2006-01-18

    Dengue is a mosquito-borne viral infection that is now endemic in most tropical countries. In Thailand, dengue fever/dengue hemorrhagic fever is a leading cause of hospitalization and death among children. A longitudinal study among 1750 people in two rural and one urban sites in northern Thailand from 2001 to 2003 studied spatial and temporal determinants for recent dengue infection at three levels (time, individual and household). Determinants for dengue infection were measured by questionnaire, land-cover maps and GIS. IgM antibodies against dengue were detected by ELISA. Three-level multi-level analysis was used to study the risk determinants of recent dengue infection. Rates of recent dengue infection varied substantially in time from 4 to 30%, peaking in 2002. Determinants for recent dengue infection differed per site. Spatial clustering was observed, demonstrating variation in local infection patterns. Most of the variation in recent dengue infection was explained at the time-period level. Location of a person and the environment around the house (including irrigated fields and orchards) were important determinants for recent dengue infection. We showed the focal nature of asymptomatic dengue infections. The great variation of determinants for recent dengue infection in space and time should be taken into account when designing local dengue control programs.

  12. Vitamin D serostatus and dengue fever progression to dengue hemorrhagic fever/dengue shock syndrome.

    Science.gov (United States)

    Villamor, E; Villar, L A; Lozano, A; Herrera, V M; Herrán, O F

    2017-10-01

    Vitamin D could modulate pathways leading to dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS). We examined the associations of serum total 25-hydroxy vitamin D [25(OH)D] and vitamin D binding protein (VDBP) concentrations in patients with uncomplicated dengue fever (DF) with risk of progression to DHF/DSS. In a case-control study nested in a cohort of DF patients who were followed during the acute episode in Bucaramanga, Colombia, we compared 25(OH)D and VDBP at onset of fever between 110 cases who progressed to DHF/DSS and 235 DF controls who did not progress. 25(OH)D concentrations were also compared between the acute sample and a sample collected >1 year post-convalescence in a subgroup. Compared with 25(OH)D ⩾75 nmol/l, adjusted odds ratios (95% CI) for progression were 0·44 (0·22-0·88) and 0·13 (0·02-1·05) for 50 to 75 nmol/l (vitamin D insufficiency) and <50 nmol/l (vitamin D deficiency), respectively (P, trend = 0·003). Mean 25(OH)D concentrations were much lower post-convalescence compared with the acute episode, regardless of case status. Compared with controls, mean VDBP was non-significantly lower in cases. We conclude that low serum 25(OH)D concentrations in DF patients predict decreased odds of progression to DHF/DSS.

  13. The prevention and control of dengue after Typhoon Haiyan

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    Charito Aumentado

    2015-11-01

    Full Text Available Objective: Many of the areas in the Philippines affected by Typhoon Haiyan are endemic for dengue; therefore, dengue prevention was a priority in the initial post-disaster risk assessment. We describe the dengue prevention and response strategies applied after Haiyan. Methods: The dengue response was implemented by a wide range of national and international stakeholders. Priorities included the rapid re-establishment of an effective surveillance system to quickly identify new dengue cases, monitor trends and determine the geographical distribution of cases. Dengue rapid diagnostic tests (RDTs were distributed to sentinel health facilities, and comprehensive vector control activities and entomological surveys were implemented. Several training sessions for key stakeholders and awareness campaigns for communities were organized. Results: There were RDT-positive dengue cases reported from urban and semi-urban areas where entomological surveys also confirmed a high density of Aedes aegypti mosquitoes. Although there was an increase in dengue cases in January 2014, the number of cases remained below the epidemic threshold throughout the remaining months of 2014. Discussion: There was no large outbreak of dengue after Typhoon Haiyan, possibly due to the targeted, multifaceted and rapid response for dengue after Haiyan. However, surveillance differed after Haiyan, making comparisons with previous years difficult. Multiple players contributed to the response that was also facilitated by close communication and coordination within the Health Cluster.

  14. Biomarkers in differentiating clinical dengue cases: A prospective cohort study

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    Gary Kim Kuan Low

    2015-12-01

    Full Text Available Objective: To evaluate five biomarkers (neopterin, vascular endothelial growth factor-A, thrombomodulin, soluble vascular cell adhesion molecule 1 and pentraxin 3 in differentiating clinical dengue cases. Methods: A prospective cohort study was conducted whereby the blood samples were obtained at day of presentation and the final diagnosis were obtained at the end of patients’ follow-up. All patients included in the study were 15 years old or older, not pregnant, not infected by dengue previously and did not have cancer, autoimmune or haematological disorder. Median test was performed to compare the biomarker levels. A subgroup Mann-Whitney U test was analysed between severe dengue and non-severe dengue cases. Monte Carlo method was used to estimate the 2-tailed probability (P value for independent variables with unequal number of patients. Results: All biomarkers except thrombomodulin has P value < 0.001 in differentiating among the healthy subjects, non-dengue fever, dengue without warning signs and dengue with warning signs/severe dengue. Subgroup analysis for all the biomarkers between severe dengue and non-severe dengue cases was not statistically significant except vascular endothelial growth factor-A (P < 0.05. Conclusions: Certain biomarkers were able to differentiate the clinical dengue cases. This could be potentially useful in classifying and determining the severity of dengue infected patients in the hospital.

  15. Clinical score to differentiate scrub typhus and dengue: A tool to differentiate scrub typhus and dengue

    Directory of Open Access Journals (Sweden)

    Shubhanker Mitra

    2017-01-01

    Full Text Available Background: Dengue and scrub typhus share similar clinical and epidemiological features, and are difficult to differentiate at initial presentation. Many places are endemic to both these infections where they comprise the majority of acute undifferentiated febrile illnesses. Materials and Methods: We aimed to develop a score that can differentiate scrub typhus from dengue. In this cross-sectional study, 188 cases of scrub typhus and 201 cases of dengue infection who presented to the emergency department or medicine outpatient clinic from September 2012 to April 2013 were included. Univariate followed by multivariate logistic regression analysis was performed to identify clinical features and laboratory results that were significantly different between the two groups. Each variable was assigned scores based on the strength of association and receiver operating characteristics area under the curve (ROC-AUC was generated and compared. Six scoring models were explored to ascertain the model with the best fit. Results: Model 2 was developed using the following six variables: oxygen saturation (>90%, ≤90%, total white blood cell count (7000 cells/cumm, hemoglobin (≤14 and >14 g/dL, total bilirubin (200 and ≥200 IU/dL, and altered sensorium (present or absent. Each variable was assigned scores based on its strength of association. The AUC-ROC curve (95% confidence interval for model 2 was 0.84 (0.79–0.89. At the cut off score of 13, the sensitivity and specificity were 85% and 77% respectively, with a higher score favoring dengue. Conclusion: In areas of high burden of ST and dengue, model 2 (the “clinical score to differentiate scrub typhus and dengue fever” is a simple and rapid clinical scoring system that may be used to differentiate scrub typhus and dengue at initial presentation.

  16. Clinical Score to Differentiate Scrub Typhus and Dengue: A Tool to Differentiate Scrub Typhus and Dengue.

    Science.gov (United States)

    Mitra, Shubhanker; Gautam, Ira; Jambugulam, Mohan; Abhilash, Kundavaram Paul Prabhakar; Jayaseeelan, Vishalakshi

    2017-01-01

    Dengue and scrub typhus share similar clinical and epidemiological features, and are difficult to differentiate at initial presentation. Many places are endemic to both these infections where they comprise the majority of acute undifferentiated febrile illnesses. We aimed to develop a score that can differentiate scrub typhus from dengue. In this cross-sectional study, 188 cases of scrub typhus and 201 cases of dengue infection who presented to the emergency department or medicine outpatient clinic from September 2012 to April 2013 were included. Univariate followed by multivariate logistic regression analysis was performed to identify clinical features and laboratory results that were significantly different between the two groups. Each variable was assigned scores based on the strength of association and receiver operating characteristics area under the curve (ROC-AUC) was generated and compared. Six scoring models were explored to ascertain the model with the best fit. Model 2 was developed using the following six variables: oxygen saturation (>90%, ≤90%), total white blood cell count (7000 cells/cumm), hemoglobin (≤14 and >14 g/dL), total bilirubin (200 and ≥200 IU/dL), and altered sensorium (present or absent). Each variable was assigned scores based on its strength of association. The AUC-ROC curve (95% confidence interval) for model 2 was 0.84 (0.79-0.89). At the cut off score of 13, the sensitivity and specificity were 85% and 77% respectively, with a higher score favoring dengue. In areas of high burden of ST and dengue, model 2 (the "clinical score to differentiate scrub typhus and dengue fever") is a simple and rapid clinical scoring system that may be used to differentiate scrub typhus and dengue at initial presentation.

  17. Método de varredura para exame de criadouros de vetores de dengue e febre amarela urbana Sweeping method to scan breeding places for dengue and urban yellow fever vectors

    Directory of Open Access Journals (Sweden)

    Roseane Lieko Kubota

    2003-04-01

    Full Text Available Com objetivo de estimar o número mínimo de varreduras para coletar uma amostra representativa das larvas presentes em um grande recipiente, foram adicionadas 200 larvas de quarto estádio em um tambor de 80 litros de água. Com auxílio de peneira plástica, foram feitas dez varreduras em cada réplica do experimento. Os resultados indicaram que oito varreduras foram suficientes para coletar até 72% do total de 200 larvas de quarto estadio presentes no criadouro, ou seja, uma média de 143±1,97. A técnica mostrou ser de fácil e eficiente execução quanto à inspeção de criadouros com grande volume de água. Isto reforça sua utilização como instrumento com grande potencial para vigilância vetorial na rotina dos programas de controle de vetores do dengue e febre amarela.To estimate the minimum numbers of "sweepings" for a representative sampling of larvae in a large container. 200 larvae in 4th stage were added in an 80-liter drum to carry out the experiment, in each retort was made 10 sweepings using a plastic sieve. Two hundred larvae in stage 4 were added to an 80-liter-drum and using a plastic sieve10 sweepings were carried out in each experiment replicate. The results showed that 8 sweepings were enough to collect up to 72% of the total sample in the container, i.e., an average of 143±1.97. The proposed method proved to be easily and effectively implemented and allowed for the inspection of containers with large water volumes. These findings reinforce its use as an important potential tool in the routine vectorial surveillance of control programs of dengue and yellow fever.

  18. Modelando o projeto logístico de uma indústria multicommodity

    Directory of Open Access Journals (Sweden)

    Everton da Silveira Farias

    Full Text Available Resumo: Neste trabalho apresentamos duas diferentes formulações matemáticas para o Projeto de Rede da Cadeia de Suprimentos de uma empresa responsável por produção e distribuição multicommodity. O investimento em uma nova fábrica exigiu a readequação do projeto logístico da empresa, implicando na reestruturação dos fluxos de matérias-primas e produtos acabados, assim como a abertura de novos CD. A cadeia de suprimentos foi modelada utilizando-se uma formulação em programação inteira linear mista na qual as facilidades são representadas pelos nós e os links, pelos arcos. As implementações computacionais foram realizadas em OPL e os resultados obtidos utilizando-se o solver CPLEX©. Para validar os modelos implementados, uma série de experimentos computacionais foi realizada. Para viabilizar a aplicação dos modelos ao problema da empresa, estudos para identificar as demandas de mercado (market shares e os custos de transporte foram incorporados ao trabalho. A aplicação dos modelos apoiou várias decisões referentes ao projeto inicial da empresa, realizadas pela equipe de projeto.

  19. Knowledge and practice regarding dengue and chikungunya

    DEFF Research Database (Denmark)

    Kajeguka, Debora C; Desrochers, Rachelle E; Mwangi, Rose

    2017-01-01

    OBJECTIVE: To investigate knowledge and prevention practices regarding dengue and chikungunya amongst community members, as well as knowledge, treatment and diagnostic practices among healthcare workers. METHOD: We conducted a cross-sectional survey with 125 community members and 125 healthcare...... good knowledge. We conducted qualitative survey (n = 40) to further assess knowledge and practice regarding dengue and chikungunya fever. RESULTS: 15.2% (n = 19) of community members had good knowledge regarding dengue, whereas 53.6%, (n = 67) of healthcare workers did. 20.3% (n = 16) of participants...... from lowland areas and 6.5% (n = 3) from highland areas had good knowledge of dengue (χ(2) = 4.25, P = 0.03). Only 2.4% (n = 3) of all participants had a good knowledge score for chikungunya. In the qualitative study, community members expressed uncertainty about dengue and chikungunya. Some healthcare...

  20. OGLE ATLAS OF CLASSICAL NOVAE. II. MAGELLANIC CLOUDS

    Energy Technology Data Exchange (ETDEWEB)

    Mróz, P.; Udalski, A.; Poleski, R.; Soszyński, I.; Szymański, M. K.; Pietrzyński, G.; Wyrzykowski, Ł.; Ulaczyk, K.; Kozłowski, S.; Pietrukowicz, P.; Skowron, J., E-mail: pmroz@astrouw.edu.pl [Warsaw University Observatory, Al. Ujazdowskie 4, 00-478 Warszawa (Poland)

    2016-01-15

    The population of classical novae in the Magellanic Clouds was poorly known because of a lack of systematic studies. There were some suggestions that nova rates per unit mass in the Magellanic Clouds were higher than in any other galaxy. Here, we present an analysis of data collected over 16 years by the OGLE survey with the aim of characterizing the nova population in the Clouds. We found 20 eruptions of novae, half of which are new discoveries. We robustly measure nova rates of 2.4 ± 0.8 yr{sup −1} (LMC) and 0.9 ± 0.4 yr{sup −1} (SMC) and confirm that the K-band luminosity-specific nova rates in both Clouds are 2–3 times higher than in other galaxies. This can be explained by the star formation history in the Magellanic Clouds, specifically the re-ignition of the star formation rate a few Gyr ago. We also present the discovery of the intriguing system OGLE-MBR133.25.1160, which mimics recurrent nova eruptions.

  1. Magnetic novae

    Science.gov (United States)

    Zemko, Polina; Orio, Marina

    2016-07-01

    We present the results of optical and X-ray observations of two quiescent novae, V2491 Cyg and V4743 Sgr. Our observations suggest the intriguing possibility of localization of hydrogen burning in magnetic novae, in which accretion is streamed to the polar caps. V2491 Cyg was observed with Suzaku more than 2 years after the outburst and V4743 Sgr was observed with XMM Newton 2 and 3.5 years after maximum. In the framework of a monitoring program of novae previously observed as super soft X-ray sources we also obtained optical spectra of V4743 Sgr with the SALT telescope 11.5 years after the eruption and of V2491 Cyg with the 6m Big Azimutal Telescope 4 and 7 years post-outburst. In order to confirm the possible white dwarf spin period of V2491 Cyg measured in the Suzaku observations we obtained photometric data using the 90cm WIYN telescope at Kitt Peak and the 1.2 m telescope in Crimea. We found that V4743 Sgr is an intermediate polar (IP) and V2491 Cyg is a strong IP candidate. Both novae show modulation of their X-ray light curves and have X-ray spectra typical of IPs. The Suzaku and XMM Newton exposures revealed that the spectra of both novae have a very soft blackbody-like component with a temperature close to that of the hydrogen burning white dwarfs in their SSS phases, but with flux by at least two orders of magnitude lower, implying a possible shrinking of emitting regions in the thin atmosphere that is heated by nuclear burning underneath it. In quiescent IPs, independently of the burning, an ultrasoft X-ray flux component originates at times in the polar regions irradiated by the accretion column, but the soft component of V4743 Sgr disappeared in 2006, indicating that the origin may be different from accretion. We suggest it may have been due to an atmospheric temperature gradient on the white dwarf surface, or to continuing localized thermonuclear burning at the bottom of the envelope, before complete turn-off. The optical spectra of V2491 Cyg and V

  2. Re-assess Vector Indices Threshold as an Early Warning Tool for Predicting Dengue Epidemic in a Dengue Non-endemic Country.

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    Fong-Shue Chang

    Full Text Available Despite dengue dynamics being driven by complex interactions between human hosts, mosquito vectors and viruses that are influenced by climate factors, an operational model that will enable health authorities to anticipate the outbreak risk in a dengue non-endemic area has not been developed. The objectives of this study were to evaluate the temporal relationship between meteorological variables, entomological surveillance indices and confirmed dengue cases; and to establish the threshold for entomological surveillance indices including three mosquito larval indices [Breteau (BI, Container (CI and House indices (HI] and one adult index (AI as an early warning tool for dengue epidemic.Epidemiological, entomological and meteorological data were analyzed from 2005 to 2012 in Kaohsiung City, Taiwan. The successive waves of dengue outbreaks with different magnitudes were recorded in Kaohsiung City, and involved a dominant serotype during each epidemic. The annual indigenous dengue cases usually started from May to June and reached a peak in October to November. Vector data from 2005-2012 showed that the peak of the adult mosquito population was followed by a peak in the corresponding dengue activity with a lag period of 1-2 months. Therefore, we focused the analysis on the data from May to December and the high risk district, where the inspection of the immature and mature mosquitoes was carried out on a weekly basis and about 97.9% dengue cases occurred. The two-stage model was utilized here to estimate the risk and time-lag effect of annual dengue outbreaks in Taiwan. First, Poisson regression was used to select the optimal subset of variables and time-lags for predicting the number of dengue cases, and the final results of the multivariate analysis were selected based on the smallest AIC value. Next, each vector index models with selected variables were subjected to multiple logistic regression models to examine the accuracy of predicting the

  3. Dengue Contingency Planning: From Research to Policy and Practice

    Science.gov (United States)

    Runge-Ranzinger, Silvia; Kroeger, Axel; Olliaro, Piero; McCall, Philip J.; Sánchez Tejeda, Gustavo; Lloyd, Linda S.; Hakim, Lokman; Bowman, Leigh R.; Horstick, Olaf; Coelho, Giovanini

    2016-01-01

    Background Dengue is an increasingly incident disease across many parts of the world. In response, an evidence-based handbook to translate research into policy and practice was developed. This handbook facilitates contingency planning as well as the development and use of early warning and response systems for dengue fever epidemics, by identifying decision-making processes that contribute to the success or failure of dengue surveillance, as well as triggers that initiate effective responses to incipient outbreaks. Methodology/Principal findings Available evidence was evaluated using a step-wise process that included systematic literature reviews, policymaker and stakeholder interviews, a study to assess dengue contingency planning and outbreak management in 10 countries, and a retrospective logistic regression analysis to identify alarm signals for an outbreak warning system using datasets from five dengue endemic countries. Best practices for managing a dengue outbreak are provided for key elements of a dengue contingency plan including timely contingency planning, the importance of a detailed, context-specific dengue contingency plan that clearly distinguishes between routine and outbreak interventions, surveillance systems for outbreak preparedness, outbreak definitions, alert algorithms, managerial capacity, vector control capacity, and clinical management of large caseloads. Additionally, a computer-assisted early warning system, which enables countries to identify and respond to context-specific variables that predict forthcoming dengue outbreaks, has been developed. Conclusions/Significance Most countries do not have comprehensive, detailed contingency plans for dengue outbreaks. Countries tend to rely on intensified vector control as their outbreak response, with minimal focus on integrated management of clinical care, epidemiological, laboratory and vector surveillance, and risk communication. The Technical Handbook for Surveillance, Dengue Outbreak

  4. Which Dengue Vaccine Approach Is the Most Promising, and Should We Be Concerned about Enhanced Disease after Vaccination? The Path to a Dengue Vaccine: Learning from Human Natural Dengue Infection Studies and Vaccine Trials.

    Science.gov (United States)

    de Silva, Aravinda M; Harris, Eva

    2018-06-01

    Dengue virus (DENV) is the most common arthropod-borne viral disease of humans. Although effective vaccines exist against other flaviviral diseases like yellow fever and Japanese encephalitis, dengue vaccine development is complicated by the presence of four virus serotypes and the possibility of partial immunity enhancing dengue disease severity. Several live attenuated dengue vaccines are being tested in human clinical trials. Initial results are mixed, with variable efficacy depending on DENV serotype and previous DENV exposure. Here, we highlight recent discoveries about the human antibody response to DENV and propose guidelines for advancing development of safe and effective dengue vaccines. Copyright © 2018 Cold Spring Harbor Laboratory Press; all rights reserved.

  5. The UBV Color Evolution of Classical and Symbiotic Novae

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    I. Hachisu

    2015-02-01

    Full Text Available We identified a general course of classical nova outbursts in the B − V vs. U − B diagram. It has been reported that novae show spectra similar to A–F supergiants near optical light maximum. However, they do not follow the supergiant sequence in the color-color diagram, neither the blackbody nor the main-sequence sequence. Instead, we found that novae evolve along a new sequence in the pre-maximum and near-maximum phases, which we call the nova-giant sequence. This sequence is parallel to but Δ(U − B ≈ −0.2 mag bluer than the supergiant sequence. After optical maximum, its color quickly evolves back blueward along the same nova-giant sequence and reaches the point of free-free emission (B − V = −0.03, U − B = −0.97 and stays there for a while, which is coincident with the intersection of the blackbody sequence and the nova-giant sequence. Then the color evolves leftward (blueward in B − V but almost constant in U − B due mainly to development of strong emission lines. This is the general course of nova outbursts in the color-color diagram, which is deduced from eight well-observed novae including various speed classes. For a nova with unknown extinction, we can determine a reliable value of the color excess by matching the observed track of the target nova with this general course. This is a new and convenient method for obtaining color excesses of classical novae. Using this method, we redetermined the color excesses of nineteen well-observed novae.

  6. Investigation of spatiotemporal relationship between dengue fever and drought

    Science.gov (United States)

    Lee, Chieh-Han; Yu, Hwa-Lung

    2016-04-01

    Dengue Fever is a vector-borne disease that is transmitted between human and mosquitos in tropical and sub-tropical regions. Previous studies have found significant relationship between the epidemic of dengue cases and climate variables, especially temperature and precipitation. Besides, the natural phenomena (e.g., drought) are considered that significantly drop the number of dengue cases by killing vector's breeding environment. However, in Kaohsiung City, Taiwan, there are evidences that the temporal pattern of dengue is correlated to drought events. Kaohsiung City experienced two main dengue outbreaks in 2002 and 2014 that both years were confirmed with serious drought. Especially in 2014, Kaohsiung City was suffered from extremely dengue outbreak in 2014 that reported the highest number of dengue cases in the history. Otherwise, another nearby city, Tainan City, had reported the biggest outbreak in 2015. This study constructs the spatiotemporal model of dengue incidences and index of drought events (Standardized Precipitation Index, SPI) based on the distributed lag nonlinear model (DLNM). Other meteorological measures are also included in the analysis.

  7. Como diferenciar uma marca num mercado pouco heterogéneo: inovação da Rip Curl

    OpenAIRE

    Real, Isabel Corte

    2011-01-01

    Mestrado em Marketing A partir de uma paixão pessoal que é o surf, e um interesse cada vez maior pelas novas tecnologias e como elas estão a mudar tudo à nossa volta, surgiu a ideia de criar um projecto para uma marca de surf que tem investido muito em Portugal, percebendo o potencial que o nosso país tem com tantos quilómetros de costa. As conclusões retiradas do quadro teórico e de toda a envolvente externa e interna à Rip Curl permitem apresentar um plano inovador para a criação de u...

  8. A CRÔNICA POÉTICA DE UMA CIDADE: O RIO EM VERSO, CANÇÃO E PROSA

    Directory of Open Access Journals (Sweden)

    Talita Carlos Tristão

    2012-01-01

    Full Text Available O diálogo entre a Música Popular Brasileira e Literatura, a partir de uma aproximação temática entre a canção “Subúrbio”, de Chico Buarque de Hollanda, e a crônica “Carioca”, de Fernando Sabino, mostra como ambos os autores compõem uma visão particular da cidade do Rio de Janeiro. Enquanto Chico opta por valorizar o cotidiano da cidade por meio de suas contradições, dando voz aos silenciados (o subúrbio; Sabino ilustra a cidade do cartão-postal, imagem congelada de um ideal já bastante saudado pela Bossa Nova.

  9. A adaptação do técnico de radiologia às novas tecnologias The adaptation of the radiologic technician to new technologies

    Directory of Open Access Journals (Sweden)

    Célia Maria Ferreira Felício

    2010-02-01

    Full Text Available OBJETIVO: Pretendeu-se avaliar a capacidade de adaptação dos técnicos de radiologia às novas tecnologias, avaliar os fatores relacionados com o processo de implementação das novas tecnologias e conhecer algumas vantagens e desvantagens identificadas pelos técnicos de radiologia. MATERIAIS E MÉTODOS: Tratou-se de um estudo descritivo e transversal. Os dados foram recolhidos através de um questionário estruturado em quatro componentes - caracterização da amostra, avaliação da opinião acerca das novas tecnologias, escala de satisfação com a utilização de sistemas de informação, e a escala de avaliação geral dos sistemas de informação -, tendo sido garantidos o anonimato e a confidencialidade dos dados. Participaram neste estudo 58 técnicos de radiologia a exercer funções em instituições hospitalares da região de Trás-os-Montes e Alto Douro, Portugal. RESULTADOS: Os resultados obtidos permitiram-nos constatar que a totalidade dos técnicos afirma que a nova tecnologia é vista como uma ferramenta de trabalho com utilidade para a sua atividade profissional, sendo que as vantagens da implementação das novas tecnologias refletem-se na facilidade de acesso ao arquivo radiológico do usuário, na diminuição da perda de informação, na rapidez de execução dos exames e no rigor dos registros do usuário. CONCLUSÃO: Podemos dizer, de uma maneira geral, que os técnicos de radiologia se adaptaram de uma forma muito satisfatória às novas tecnologias implementadas nos seus departamentos.OBJECTIVE: The present study was aimed at evaluating radiologic technicians' capacity to adapt to new technologies, besides investigating which factors could be related to the implementation of new technologies and to identify some of its possible advantages and disadvantages as well. MATERIALS AND METHODS: The present descriptive and cross-sectional study evaluated data collected by means of a structured questionnaire divided into four

  10. Multi-level analyses of spatial and temporal determinants for dengue infection

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    Oskam Linda

    2006-01-01

    Full Text Available Abstract Background Dengue is a mosquito-borne viral infection that is now endemic in most tropical countries. In Thailand, dengue fever/dengue hemorrhagic fever is a leading cause of hospitalization and death among children. A longitudinal study among 1750 people in two rural and one urban sites in northern Thailand from 2001 to 2003 studied spatial and temporal determinants for recent dengue infection at three levels (time, individual and household. Methods Determinants for dengue infection were measured by questionnaire, land-cover maps and GIS. IgM antibodies against dengue were detected by ELISA. Three-level multi-level analysis was used to study the risk determinants of recent dengue infection. Results Rates of recent dengue infection varied substantially in time from 4 to 30%, peaking in 2002. Determinants for recent dengue infection differed per site. Spatial clustering was observed, demonstrating variation in local infection patterns. Most of the variation in recent dengue infection was explained at the time-period level. Location of a person and the environment around the house (including irrigated fields and orchards were important determinants for recent dengue infection. Conclusion We showed the focal nature of asymptomatic dengue infections. The great variation of determinants for recent dengue infection in space and time should be taken into account when designing local dengue control programs.

  11. Internet: desafio para uma contabilidade interativa

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    Armando Catelli

    2001-04-01

    Full Text Available O fenômeno explosivo da Internet, insuspeitado há 10 anos, e que hoje se expande de modo acelerado e abrangente em todas as atividades humanas, tem impactos relevantes também na contabilidade. A interatividade, como característica da nova forma de comunicação inaugurada com a Internet, apresenta desafios ao Sistema Contábil Gerencial, cujas respostas, na forma de uma visão interativa da empresa, do patrimônio e do processo de gestão, se expressam na abordagem do Sistema de Gestão Econômica. As insuficiências da Contabilidade Financeira em expressar a realidade das empresas da nova economia no mercado de capitais são igualmente identificadas. Ao mesmo tempo, são comentadas as oportunidades que se abrem à contabilidade financeira, com a divulgação das demonstrações mediante os recursos de linguagem da Internet, com base nos projetos desenvolvidos por entidades reguladoras, particularmente pelo International Accounting Standards Committee (IASC. Com o incremento da comunicação contábil interativa via Internet e com o aprofundamento do debate sobre a contabilização das empresas de ativos intelectuais intensivos, como as da nova economia, preconiza-se, sob a égide da interatividade, uma renovação da Contabilidade Financeira e sua maior aproximação da Contabilidade Gerencial, com base nos fundamentos da Teoria Contábil.The explosive phenomenon of the Internet, which was unsuspected ten years ago, and is now expanding in an accelerating and involving way in all human activities, has a relevant impact on accounting as well. Interactivity - one characteristic of the new communication form that was inaugurated by the Internet - raises challenges for the Management Accounting System, whose answers, in the form of an interactive view of the enterprise, its assets and its managing process, are expressed in the approach of the Economic Management System. The insufficiency of Financial Accounting to express the reality of the new

  12. Prevention and Control Strategies to Counter Dengue Virus Infection

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    Irfan A. Rather

    2017-07-01

    Full Text Available Dengue is currently the highest and rapidly spreading vector-borne viral disease, which can lead to mortality in its severe form. The globally endemic dengue poses as a public health and economic challenge that has been attempted to suppress though application of various prevention and control techniques. Therefore, broad spectrum techniques, that are efficient, cost-effective, and environmentally sustainable, are proposed and practiced in dengue-endemic regions. The development of vaccines and immunotherapies have introduced a new dimension for effective dengue control and prevention. Thus, the present study focuses on the preventive and control strategies that are currently employed to counter dengue. While traditional control strategies bring temporary sustainability alone, implementation of novel biotechnological interventions, such as sterile insect technique, paratransgenesis, and production of genetically modified vectors, has improved the efficacy of the traditional strategies. Although a large-scale vector control strategy can be limited, innovative vaccine candidates have provided evidence for promising dengue prevention measures. The use of tetravalent dengue vaccine (CYD-TDV has been the most effective so far in treating dengue infections. Nonetheless, challenges and limitation hinder the progress of developing integrated intervention methods and vaccines; while the improvement in the latest techniques and vaccine formulation continues, one can hope for a future without the threat of dengue virus.

  13. Prevention and Control Strategies to Counter Dengue Virus Infection.

    Science.gov (United States)

    Rather, Irfan A; Parray, Hilal A; Lone, Jameel B; Paek, Woon K; Lim, Jeongheui; Bajpai, Vivek K; Park, Yong-Ha

    2017-01-01

    Dengue is currently the highest and rapidly spreading vector-borne viral disease, which can lead to mortality in its severe form. The globally endemic dengue poses as a public health and economic challenge that has been attempted to suppress though application of various prevention and control techniques. Therefore, broad spectrum techniques, that are efficient, cost-effective, and environmentally sustainable, are proposed and practiced in dengue-endemic regions. The development of vaccines and immunotherapies have introduced a new dimension for effective dengue control and prevention. Thus, the present study focuses on the preventive and control strategies that are currently employed to counter dengue. While traditional control strategies bring temporary sustainability alone, implementation of novel biotechnological interventions, such as sterile insect technique, paratransgenesis, and production of genetically modified vectors, has improved the efficacy of the traditional strategies. Although a large-scale vector control strategy can be limited, innovative vaccine candidates have provided evidence for promising dengue prevention measures. The use of tetravalent dengue vaccine (CYD-TDV) has been the most effective so far in treating dengue infections. Nonetheless, challenges and limitation hinder the progress of developing integrated intervention methods and vaccines; while the improvement in the latest techniques and vaccine formulation continues, one can hope for a future without the threat of dengue virus.

  14. A relação entre as crenças verbalizadas e depreendidas das ações do professor de Língua Inglesa no que tange ao ensino mediado pelas novas tecnologias

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    Kássia Gonçalves Arantes

    2012-12-01

    Full Text Available O objetivo deste trabalho é investigar a relação entre o dizer e o fazer do professor, no que tange à influência das novas tecnologias no ensino e aprendizagem de língua inglesa, bem como identificar os fatores que se articulam para o estabelecimento dessa relação. Para tanto, fazemos o confronto entre as crenças manifestadas no dizer do professor e as crenças depreendidas de seu fazer. Inserida numa perspectiva predominantemente qualitativa de cunho interpretativista, a pesquisa adota uma abordagem contextual de investigação de crenças de professores. O trabalho é fundamentado teoricamente em estudos que abordam as crenças de professores, o papel das novas tecnologias nos processos de ensino e aprendizagem de língua estrangeria, e a relação entre o professor reflexivo e a utilização das novas tecnologias. Os principais resultados encontrados apontam predominantemente para uma relação de dissonância entre o dizer e o fazer dos professores, e os fatores articuladores dessa relação se enquadram em quatro classes, a saber: fatores contextuais, experienciais, cognitivos e afetivos.

  15. Karl Polanyi e a Nova Sociologia Económica: Notas sobre o conceito de (disembeddedness

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    Nuno Miguel Cardoso Machado

    2012-10-01

    Full Text Available No contexto da Nova Sociologia Económica, Karl Polanyi é quase consensualmente considerado o “pai” do conceito de incrustação (embeddedness. Todavia, este conceito foi alvo de uma apropriação selectiva por parte da disciplina, sendo negligenciada a sua relação com o restante edifício teórico construído por Polanyi. Pode, com efeito, falar‑se de uma “grande transformação” sofrida pelo conceito de incrustação: se em Polanyi ele está associado a um nível macro(económico e é utilizado para evidenciar o carácter excepcional da economia capitalista de mercado – que se encontra desincrustada da sociedade –, na NSE, por seu turno, é normalmente associado a um nível meso (e até micro, sendo preconizado que todas as economias – incluindo a capitalista – estão incrustadas.

  16. Household costs of dengue illness: secondary outcomes from a randomised controlled trial of dengue prevention in Guerrero state, Mexico.

    Science.gov (United States)

    Legorreta-Soberanis, José; Paredes-Solís, Sergio; Morales-Pérez, Arcadio; Nava-Aguilera, Elizabeth; Serrano-de Los Santos, Felipe René; Dimas-Garcia, Diana Lisseth; Ledogar, Robert J; Cockcroft, Anne; Andersson, Neil

    2017-05-30

    Dengue is a serious public health problem with an important economic impact. This study used data from a cluster randomised controlled trial of community mobilisation for dengue prevention to estimate the household costs of treatment of dengue illness. It examined the economic impact of the trial intervention in the three coastal regions of Mexico's Guerrero State. The 2010 baseline survey covered households in a random sample of 90 clusters in the coastal regions; the clusters were randomly allocated to intervention or control and re-surveyed in 2012. The surveys asked about dengue cases in the last 12 months, expenditures on their treatment, and work or school days lost by patients and care givers. We did not assign monetary value to days lost, since a lost day to a person of low earning power is of equal or higher value to that person than to one who earns more. The 12,312 households in 2010 reported 1020 dengue cases in the last 12 months (1.9% of the sample population). Most (78%) were ambulatory cases, with a mean cost of USD 51 and 10.8 work/school days, rising to USD 96 and 11.4 work/school days if treated by a private physician. Hospitalised cases cost USD 28-94 in government institutions and USD 392 in private hospitals (excluding additional inpatient charges), as well as 9.6-17.3 work/school days. Dengue cases cost households an estimated 412,825 work/school days throughout the three coastal regions. In the follow up survey, 6.1% (326/5349) of households in intervention clusters and 7.9% (405/5139) in control clusters reported at least one dengue case. The mean of days lost per case was similar in intervention and control clusters, but the number of days lost from dengue and all elements of costs for dengue cases per 1000 population were lower in intervention clusters. If the total population of the three coastal regions had received the intervention, some 149,401 work or school days lost per year could have been prevented. The economic effect of

  17. Pediatric ischemic stroke due to dengue vasculitis.

    Science.gov (United States)

    Nanda, Subrat Kumar; Jayalakshmi, Sita; Mohandas, Surath

    2014-10-01

    Dengue infection is an important arboviral infection in southeast Asia, especially in India. Neurological manifestations of dengue are increasingly recognized. We report an ischemic stroke due to dengue vasculitis in an 8-year-old child. We present a girl with a short febrile illness followed by episodic severe headache, with gradually progressive hemiparesis and visual impairment. Her brain magnetic resonance imaging revealed multiple infarctions in the anterior and posterior circulation. The magnetic resonance angiogram revealed irregular narrowing of bilateral middle cerebral arteries, right anterior cerebral artery, left posterior cerebral, and bilateral vertebral arteries suggestive of vasculitis. Her dengue serology was strongly positive for immunoglobulin M with 68.9 panbio units. The rest of the evaluation for pediatric stroke was unremarkable. She was treated with intravenous followed by oral corticosteroids and recovered totally with resolution of vasculitis on magnetic resonance angiogram over the next 3 months. This child illustrates possible immune-mediated vasculitis caused by dengue infection which is rather a rare presentation in a child who subsequently recovered well. One should consider dengue in childhood strokes in endemic regions. Copyright © 2014 Elsevier Inc. All rights reserved.

  18. Nine year trends of dengue virus infection in Mumbai, Western India.

    Science.gov (United States)

    Shastri, Jayanthi; Williamson, Manita; Vaidya, Nilima; Agrawal, Sachee; Shrivastav, Om

    2017-01-01

    Dengue virus (DENV) causes a wide range of diseases in humans, from acute febrile illness Dengue fever (DF) to life-threatening Dengue hemorrhagic fever (DHF) or Dengue shock syndrome (DSS). Factors believed to be responsible for spread of Dengue virus infection include explosive population growth, unplanned urban overpopulation with inadequate public health systems, poor standing water and vector control, climate changes and increased international recreational, business, military travel to endemic areas. All of these factors must be addressed to control the spread of Dengue and other mosquito-borne infections. The detection of Dengue virus RNA by reverse transcriptase PCR (RT-PCR) in human serum or plasma samples is highly indicative of acute Dengue fever. Moreover, the method is able to identify the Dengue virus serotype by demonstrating defined sequence homologies in the viral genomic RNA. During the nine year period of this study analysis, 6767 strongly suspected cases were tested by RT-PCR. 1685 (24.9%) were Dengue PCR positive and confirmed as Dengue cases. Observations on the seasonality were based on the nine year's data as the intensity of sampling was at its maximum during monsoon season. Dengue typing was done on 100 positive samples after storage of Dengue RNA at - 80°C. Dengue serotypes were detected in 69 samples of which Dengue 2 was most predominant. 576 samples were processed for NS1 antigen and PCR simultaneously. 19/576 were positive (3.3 %) for NS1 as well as by PCR. 23/576 samples were negative for NS1 antigen, but were positive by RT-PCR. The remaining 534 samples which were negative for NS1 antigen were also negative by Dengue RT-PCR. In this study we sought to standardize rapid, sensitive, and specific fluorogenic probe-based RT-PCR assay to screen and serotype a representative range of Dengue viruses that are found in and around Mumbai. Qualitative Dengue virus TaqMan assays could have tremendous utility for the epidemiological

  19. A nova outburst powered by shocks

    Science.gov (United States)

    Li, Kwan-Lok; Metzger, Brian D.; Chomiuk, Laura; Vurm, Indrek; Strader, Jay; Finzell, Thomas; Beloborodov, Andrei M.; Nelson, Thomas; Shappee, Benjamin J.; Kochanek, Christopher S.; Prieto, José L.; Kafka, Stella; Holoien, Thomas W.-S.; Thompson, Todd A.; Luckas, Paul J.; Itoh, Hiroshi

    2017-10-01

    Classical novae are runaway thermonuclear burning events on the surfaces of accreting white dwarfs in close binary star systems, sometimes appearing as new naked-eye sources in the night sky1. The standard model of novae predicts that their optical luminosity derives from energy released near the hot white dwarf, which is reprocessed through the ejected material2-5. Recent studies using the Fermi Large Area Telescope have shown that many classical novae are accompanied by gigaelectronvolt γ-ray emission6,7. This emission likely originates from strong shocks, providing new insights into the properties of nova outflows and allowing them to be used as laboratories for the study of the unknown efficiency of particle acceleration in shocks. Here, we report γ-ray and optical observations of the Milky Way nova ASASSN-16ma, which is among the brightest novae ever detected in γ-rays. The γ-ray and optical light curves show a remarkable correlation, implying that the majority of the optical light comes from reprocessed emission from shocks rather than the white dwarf8. The ratio of γ-ray to optical flux in ASASSN-16ma directly constrains the acceleration efficiency of non-thermal particles to be around 0.005, favouring hadronic models for the γ-ray emission9. The need to accelerate particles up to energies exceeding 100 gigaelectronvolts provides compelling evidence for magnetic field amplification in the shocks.

  20. X-ray Modeling of Classical Novae

    Science.gov (United States)

    Nemeth, Peter

    2010-01-01

    It has been observed and theoretically supported in the last decade that the peak of the spectral energy distribution of classical novae gradually shifts to higher energies at constant bolometric luminosity after a nova event. For this reason, comprehensive evolutionary studies require spectral analysis in multiple spectral bands. After a nova explosion, the white dwarf can maintain stable surface hydrogen burning, the duration of which strongly correlates with the white dwarf mass. During this stage the peak of the luminosity is in the soft X-ray band (15 - 60 Angstroms). By extending the modeling range of TLUSTY/SYNSPEC, I analyse the luminosity and abundance evolution of classical novae. Model atoms required for this work were built using atomic data from NIST/ASD and TOPBASE. The accurate but incomplete set of energy levels and radiative transitions in NIST were completed with calculated data from TOPBASE. Synthetic spectra were then compared to observed data to derive stellar parameters. I show the capabilities and validity of this project on the example of V4743 Sgr. This nova was observed with both Chandra and XMM-Newton observatories and has already been modeled by several scientific groups (PHOENIX, TMAP).

  1. Cost of dengue outbreaks: literature review and country case studies.

    Science.gov (United States)

    Stahl, Hans-Christian; Butenschoen, Vicki Marie; Tran, Hien Tinh; Gozzer, Ernesto; Skewes, Ronald; Mahendradhata, Yodi; Runge-Ranzinger, Silvia; Kroeger, Axel; Farlow, Andrew

    2013-11-06

    Dengue disease surveillance and vector surveillance are presumed to detect dengue outbreaks at an early stage and to save--through early response activities--resources, and reduce the social and economic impact of outbreaks on individuals, health systems and economies. The aim of this study is to unveil evidence on the cost of dengue outbreaks. Economic evidence on dengue outbreaks was gathered by conducting a literature review and collecting information on the costs of recent dengue outbreaks in 4 countries: Peru, Dominican Republic, Vietnam, and Indonesia. The literature review distinguished between costs of dengue illness including cost of dengue outbreaks, cost of interventions and cost-effectiveness of interventions. Seventeen publications on cost of dengue showed a large range of costs from 0.2 Million US$ in Venezuela to 135.2 Million US$ in Brazil. However, these figures were not standardized to make them comparable. Furthermore, dengue outbreak costs are calculated differently across the publications, and cost of dengue illness is used interchangeably with cost of dengue outbreaks. Only one paper from Australia analysed the resources saved through active dengue surveillance. Costs of vector control interventions have been reported in 4 studies, indicating that the costs of such interventions are lower than those of actual outbreaks. Nine papers focussed on the cost-effectiveness of dengue vaccines or dengue vector control; they do not provide any direct information on cost of dengue outbreaks, but their modelling methodologies could guide future research on cost-effectiveness of national surveillance systems.The country case studies--conducted in very different geographic and health system settings - unveiled rough estimates for 2011 outbreak costs of: 12 million US$ in Vietnam, 6.75 million US$ in Indonesia, 4.5 million US$ in Peru and 2.8 million US$ in Dominican Republic (all in 2012 US$). The proportions of the different cost components (vector control

  2. A Hubble Space Telescope Survey for Novae in M87. II. Snuffing out the Maximum Magnitude–Rate of Decline Relation for Novae as a Non-standard Candle, and a Prediction of the Existence of Ultrafast Novae

    Energy Technology Data Exchange (ETDEWEB)

    Shara, Michael M.; Doyle, Trisha; Zurek, David [Department of Astrophysics, American Museum of Natural History, Central Park West and 79th Street, New York, NY 10024-5192 (United States); Lauer, Tod R. [National Optical Astronomy Observatory, P.O. Box 26732, Tucson, AZ 85726 (United States); Baltz, Edward A. [KIPAC, SLAC, 2575 Sand Hill Road, M/S 29, Menlo Park, CA 94025 (United States); Kovetz, Attay [School of Physics and Astronomy, Faculty of Exact Sciences, Tel Aviv University, Tel Aviv (Israel); Madrid, Juan P. [CSIRO, Astronomy and Space Science, P.O. Box 76, Epping, NSW 1710 (Australia); Mikołajewska, Joanna [N. Copernicus Astronomical Center, Polish Academy of Sciences, Bartycka 18, PL 00-716 Warsaw (Poland); Neill, J. D. [California Institute of Technology, 1200 East California Boulevard, MC 278-17, Pasadena CA 91125 (United States); Prialnik, Dina [Department of Geosciences, Tel Aviv University, Ramat Aviv, Tel Aviv 69978 (Israel); Welch, D. L. [Department of Physics and Astronomy, McMaster University, Hamilton, L8S 4M1, Ontario (Canada); Yaron, Ofer [Department of Particle Physics and Astrophysics, Weizmann Institute of Science, 76100 Rehovot (Israel)

    2017-04-20

    The extensive grid of numerical simulations of nova eruptions from the work of Yaron et al. first predicted that some classical novae might significantly deviate from the Maximum Magnitude–Rate of Decline (MMRD) relation, which purports to characterize novae as standard candles. Kasliwal et al. have announced the observational detection of a new class of faint, fast classical novae in the Andromeda galaxy. These objects deviate strongly from the MMRD relationship, as predicted by Yaron et al. Recently, Shara et al. reported the first detections of faint, fast novae in M87. These previously overlooked objects are as common in the giant elliptical galaxy M87 as they are in the giant spiral M31; they comprise about 40% of all classical nova eruptions and greatly increase the observational scatter in the MMRD relation. We use the extensive grid of the nova simulations of Yaron et al. to identify the underlying causes of the existence of faint, fast novae. These are systems that have accreted, and can thus eject, only very low-mass envelopes, of the order of 10{sup −7}–10{sup −8} M {sub ⊙}, on massive white dwarfs. Such binaries include, but are not limited to, the recurrent novae. These same models predict the existence of ultrafast novae that display decline times, t {sub 2,} to be as short as five hours. We outline a strategy for their future detection.

  3. Incidence of dengue virus infection among Japanese travellers, 2006 to 2010

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    Yuki Tada

    2012-06-01

    Full Text Available Introduction: Dengue continues to be a global public health concern. In Japan, although dengue cases are currently seen only among travellers returning from endemic areas, the number of reported cases is rising according to the national case-based surveillance system. We evaluated the characteristics of dengue cases imported into Japan and the relationship between the incidence of infection and season of travel to popular destinations.Methods: Dengue cases reported to the national surveillance system were retrospectively examined. The number of reported cases per number of Japanese travellers to a dengue-endemic country was calculated to estimate the country-specific incidence of imported dengue virus infection. The incidence of dengue infection among Japanese travellers was compared between dengue high season and low season in each country using relative risk (RR and associated 95% confidence intervals (CI.Results: Among 540 Japanese residents who were reported as dengue cases from 2006 to 2010, the majority had travelled to Indonesia, India, the Philippines and Thailand. The RR of dengue infection among Japanese travellers during dengue high season versus low season was 4.92 (95% CI: 3.01–8.04 for the Philippines, 2.76 (95% CI: 1.67–4.54 for Thailand and 0.37 (95% CI: 0.15–0.92 for Indonesia.Discussion: Overall, higher incidence of imported cases appeared to be related to historic dengue high seasons. Travellers planning to visit dengue-endemic countries should be aware of historic dengue seasonality and the current dengue situation.

  4. Um desafio para a saúde pública brasileira: o controle do dengue Dengue control: a challenge for the public health system in Brazil

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    Maria Lucia F. Penna

    2003-02-01

    Full Text Available Este artigo problematiza a estratégia tradicional de controle do Aedes aegypti por meio do trabalho de guardas sanitários, com visitas periódicas a todas as edificações urbanas. Ela não é viável e/ou não tem factibilidade administrativa atualmente, já que vem sendo proposta desde a década de 80 e não é implementada. A reforma sanitária brasileira priorizou a ampliação da cobertura dos serviços básicos de saúde e não as ações de controle de doenças específicas. O A. aegypti reintroduzido para iniciar a reocupação de seu antigo habitat em 1976, está atualmente em um processo de reocupação do país até atingir seu equilíbrio Isto como problema de saúde coletiva, diz respeito ao meio ambiente urbano, portanto um problema de todos, população e poder público, não apenas da área de saúde. A necessidade da atuação conjunta da área de saneamento e meio ambiente neste caso é ressaltada. Deve-se também repensar a contribuição da população como efetiva e permanente, separando obrigações e direitos do poder público e da população, separando o público do privado. O perigo do reaparecimento da febre amarela deve ser considerado no estabelecimento de uma nova estratégia factível e viável para lidar com o problema do dengue.This article presents a critical analysis of the traditional strategy used to control Aedes aegypti using "health surveillance patrols", with periodic visits to all urban buildings. The strategy is not viable and/or is administratively unfeasible at present, since it has been proposed since the 1980s but has not been implemented. Brazilian health reform prioritized the expansion of coverage for basic health services, and not measures to control specific diseases. A. aegypti, which was reintroduced and began the reoccupation of its old habitat in 1976, is currently in a process of re-infesting the country until reaching equilibrium. This public health problem relates to the urban

  5. THE UNUSUALLY LUMINOUS EXTRAGALACTIC NOVA SN 2010U

    International Nuclear Information System (INIS)

    Czekala, Ian; Berger, E.; Chornock, R.; Marion, G. H.; Margutti, R.; Challis, P.; Pastorello, A.; Botticella, M. T.; Ergon, M.; Sollerman, J.; Smartt, S.; Vinkó, J.; Wheeler, J. C.

    2013-01-01

    We present observations of the unusual optical transient SN 2010U, including spectra taken 1.03 days to 15.3 days after maximum light that identify it as a fast and luminous Fe II type nova. Our multi-band light curve traces the fast decline (t 2 = 3.5 ± 0.3 days) from maximum light (M V = –10.2 ± 0.1 mag), placing SN 2010U in the top 0.5% of the most luminous novae ever observed. We find typical ejecta velocities of ≈1100 km s –1 and that SN 2010U shares many spectral and photometric characteristics with two other fast and luminous Fe II type novae, including Nova LMC 1991 and M31N-2007-11d. For the extreme luminosity of this nova, the maximum magnitude versus rate of decline relationship indicates a massive white dwarf (WD) progenitor with a low pre-outburst accretion rate. However, this prediction is in conflict with emerging theories of nova populations, which predict that luminous novae from massive WDs should preferentially exhibit an alternate spectral type (He/N) near maximum light.

  6. Clinical and epidemiological characterization of dengue hemorrhagic fever cases in northeastern, Brazil Caracterização clínica e epidemiológica dos casos de dengue hemorrágica no nordeste do Brasil

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    Luciano Pamplona de Góes Cavalcanti

    2010-08-01

    Full Text Available INTRODUCTION: The dengue hemorrhagic dengue (DHF remains an important public health problem in Brazil. The objective of this study was to analyze the epidemiological characteristics of DHF cases during the 2003 epidemic in Ceará. METHODS: Suspected DHF cases with onset of symptoms between January and December 2003 were investigated. RESULTS: 37,964 classic dengue cases and 291 DHF cases were reported. Among the cases discarded, 75.5% were serologically positive but did not meet the criteria recommended by the World Health Organization (WHO. The DHF patients' median age was 30 years (2 - 88. Among the hemorrhagic manifestations, petechiae were the most (32.6% frequent. Cases of gastrointestinal bleeding, ascites, pericardial pleural effusion, hepatomegaly, hypotension and shock showed higher risk of progression to death (p INTRODUÇÃO: A febre hemorrágica do dengue (FHD permanece como um importante problema de saúde pública no Brasil. O objetivo deste estudo é analisar os aspectos epidemiológicos dos casos de dengue hemorrágico durante a epidemia de 2003, no Ceará. MÉTODOS: Foram investigados os casos suspeitos de FHD, com início de sintomas no período de janeiro a dezembro de 2003. RESULTADOS: Foram reportados 37.964 casos de dengue clássica, com 291 casos de FHD. Entre os casos descartados, 75,5% apresentaram sorologia positiva, mas não preenchem os critérios recomendados pela Organização Mundial de Saúde. A mediana de idade dos pacientes com FHD foi de 30 anos (2 - 88. Para manifestações hemorrágicas, as petéquias com 32,6% foram as mais frequentes. Os casos de hemorragia digestiva, ascite, derrame pleural e pericárdico, hepatomegalia, hipotensão e choque apresentaram maior risco de progressão para óbito (p <0,05. CONCLUSÕES: A introdução de um novo sorotipo (DENV-3 no Ceará, encontrando a população suscetível e a alta densidade do vetor podem ter sido os principais responsáveis pela magnitude da epidemia. A

  7. Validation of dengue infection severity score

    Directory of Open Access Journals (Sweden)

    Pongpan S

    2014-03-01

    Full Text Available Surangrat Pongpan,1,2 Jayanton Patumanond,3 Apichart Wisitwong,4 Chamaiporn Tawichasri,5 Sirianong Namwongprom1,6 1Clinical Epidemiology Program, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand; 2Department of Occupational Medicine, Phrae Hospital, Phrae, Thailand; 3Clinical Epidemiology Program, Faculty of Medicine, Thammasat University, Bangkok, Thailand; 4Department of Social Medicine, Sawanpracharak Hospital, Nakorn Sawan, Thailand; 5Clinical Epidemiology Society at Chiang Mai, Chiang Mai, Thailand; 6Department of Radiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand Objective: To validate a simple scoring system to classify dengue viral infection severity to patients in different settings. Methods: The developed scoring system derived from 777 patients from three tertiary-care hospitals was applied to 400 patients in the validation data obtained from another three tertiary-care hospitals. Percentage of correct classification, underestimation, and overestimation was compared. The score discriminative performance in the two datasets was compared by analysis of areas under the receiver operating characteristic curves. Results: Patients in the validation data were different from those in the development data in some aspects. In the validation data, classifying patients into three severity levels (dengue fever, dengue hemorrhagic fever, and dengue shock syndrome yielded 50.8% correct prediction (versus 60.7% in the development data, with clinically acceptable underestimation (18.6% versus 25.7% and overestimation (30.8% versus 13.5%. Despite the difference in predictive performances between the validation and the development data, the overall prediction of the scoring system is considered high. Conclusion: The developed severity score may be applied to classify patients with dengue viral infection into three severity levels with clinically acceptable under- or overestimation. Its impact when used in routine

  8. Dengue situation in Brazil by year 2000

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    Hermann G Schatzmayr

    2000-01-01

    Full Text Available Dengue virus types 1 and 2 have been isolated in Brazil by the Department of Virology, Instituto Oswaldo Cruz, in 1986 and 1990 respectively, after many decades of absence. A successful continental Aedes aegypti control program in the Americas, has been able to eradicate the vector in most countries in the 60's, but the program could not be sustained along the years. Dengue viruses were reintroduced in the American region and the infection became endemic in Brazil, like in most Central and SouthAmerican countries and in the Caribbean region, due to the weaning of the vector control programs in these countries. High demographic densities and poor housing conditions in large urban communities, made the ideal conditions for vector spreading. All four dengue types are circulating in the continent and there is a high risk of the introduction in the country of the other two dengue types in Brazil, with the development of large epidemics. After the Cuban episode in 1981, when by the first time a large epidemic of dengue hemorrhagic fever and dengue shock syndrome have been described in the Americas, both clinical presentations are observed, specially in the countries like Brazil, with circulation of more than one dengue virus type. A tetravalent potent vaccine seems to be the only possible way to control the disease in the future, besides rapid clinical and laboratory diagnosis, in order to offer supportive treatment to the more severe clinical infections.

  9. Difusão Espacial do Dengue no Estado de São Paulo e as Suas Barreiras Geográficas | Spatial Diffusion of Dengue in the State of São Paulo and Its Geographical Boundaries

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    Rafael de Castro Catão

    2014-05-01

    Full Text Available Normal 0 21 false false false PT-BR X-NONE X-NONE Introdução:Trinta anos após sua reemergência no Brasil, o dengue já possui ciclos endêmicos/epidêmicos em quase todo o país. Devido às características sociais e ambientais do território brasileiro, aproximadamente toda sua extensão é propícia ao desenvolvimento da doença. Todavia, existem algumas áreas que nunca notificaram casos autóctones. Essas áreas correspondem à clusters de municípios com características (sociais e ambientais semelhantes, evidenciando algum fato geográfico que impede ou limita a expansão/consolidação da doença naquela área. Denominamos essas áreas, a priori, de barreiras geográficas de difusão, que dificultam ou impedem a transmissão do dengue nesses referidos clusters. O tema barreiras geográficas está inserido dentro das pesquisas sobre difusão de doenças, presentes no seio da geografia da saúde. Essa pesquisa visa estudar as barreiras de difusão do dengue no Estado de São Paulo, que aparentemente conta com quatro áreas em que não há registros de casos de dengue, ou que suas taxas estão bem abaixo da média estadual. Desta forma definimos como Hipótese da pesquisa que as barreiras geográficas de difusão do dengue no Estado de São Paulo existem e podem ser identificadas e mapeadas. O objetivo geral consiste em compreender o processo de difusão espacial do dengue no Estado de São Paulo, identificando as suas barreiras geográficas. Desenvolvimento: Para chegarmos a esse objetivo iremos delimitar conceitualmente o que seriam as barreiras geográficas de difusão do dengue e depois mapear a difusão do dengue no estado, criando modelos preditivos de barreira para a posterior análise. Para delimitarmos conceitualmente iremos, primeiramente, realizar uma revisão bibliográfica em periódicos e livros, nacionais e internacionais sobre os temas: difusão de doenças, barreiras geográficas e dengue. Concomitantemente a essa revis

  10. Host genetics and dengue fever.

    Science.gov (United States)

    Xavier-Carvalho, Caroline; Cardoso, Cynthia Chester; de Souza Kehdy, Fernanda; Pacheco, Antonio Guilherme; Moraes, Milton Ozório

    2017-12-01

    Dengue is a major worldwide problem in tropical and subtropical areas; it is caused by four different viral serotypes, and it can manifest as asymptomatic, mild, or severe. Many factors interact to determine the severity of the disease, including the genetic profile of the infected patient. However, the mechanisms that lead to severe disease and eventually death have not been determined, and a great challenge is the early identification of patients who are more likely to progress to a worse health condition. Studies performed in regions with cyclic outbreaks such as Cuba, Brazil, and Colombia have demonstrated that African ancestry confers protection against severe dengue. Highlighting the host genetics as an important factor in infectious diseases, a large number of association studies between genetic polymorphisms and dengue outcomes have been published in the last two decades. The most widely used approach involves case-control studies with candidate genes, such as the HLA locus and genes for receptors, cytokines, and other immune mediators. Additionally, a Genome-Wide Association Study (GWAS) identified SNPs associated with African ethnicity that had not previously been identified in case-control studies. Despite the increasing number of publications in America, Africa, and Asia, the results are quite controversial, and a meta-analysis is needed to assess the consensus among the studies. SNPs in the MICB, TNF, CD209, FcγRIIA, TPSAB1, CLEC5A, IL10 and PLCE1 genes are associated with the risk or protection of severe dengue, and the findings have been replicated in different populations. A thorough understanding of the viral, human genetic, and immunological mechanisms of dengue and how they interact is essential for effectively preventing dengue, but also managing and treating patients. Copyright © 2017 Elsevier B.V. All rights reserved.

  11. First Iranian imported case of dengue

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    Masoud Mardani

    2013-01-01

    Full Text Available Dengue fever, a mosquito-borne flavivirus infection, is endemic in Southeast Asia. Currently, incidences have been increasing among adults. There have been no published reports of dengue fever from Iran. Widespread connection between different countries may predispose them for acquisition of infection. The patient was a 58-year-old Iranian woman with acute unexplained high-grade fever for 4 days, associated with skin rash, after returning from Southeast Asia. CBC showed WBC = 1600/mm 3 and platelet count 99,000/mm 3 . The patient also had hematuria. ELISA immunoglobulin M (IgM antibodies to dengue and serum RT-PCR for dengue virus was positive. The patient managed with conservative treatment and due to good general condition and improvement specific antiviral treatment was not started. She became afebrile at the 3 rd day of hospitalization and discharged with good general condition on fourth day. She was afebrile after two weeks follow-up. Dengue fever has been increasing among adults. It should be suspected, when a patient presents with acute febrile illness and skin rashes returning from endemic region. Conservative treatment may be conducted in uncomplicated cases .

  12. Triphora uniflora A. C. Ferreira, Baptista & Pansarin (Orchidaceae: Triphoreae: uma nova espécie e primeiro registro do gênero Triphora Nutt. para o estado de São Paulo, Brasil Triphora uniflora A.C. Ferreira, Baptista & Pansarin (Orchidaceae: Triphoreae: a new species and the first record of the genus Triphora Nutt. for São Paulo state, Brazil

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    Alessandro Wagner Coelho Ferreira

    2010-03-01

    Full Text Available Triphora uniflora A. C. Ferreira, Baptista & Pansarin uma nova espécie de Orchidaceae, é descrita e ilustrada. Além disso, o gênero Triphora é referido pela primeira vez para o estado de São Paulo. As relações da nova espécie com outros táxons do gênero, bem como a necessidade de conservação do habitat natural dessa espécie de Triphora, são discutidas.Triphora uniflora A. C. Ferreira, Baptista & Pansarin, a new species of Orchidaceae, is described and illustrated. Furthermore, this is the first report of the genus Triphora for São Paulo state, Brazil. The relationship of this new species to other taxa of the genus and the need to preserve the natural habitat of this Triphora species are discussed.

  13. O DESAFIO DO EMPREENDEDORISMO LOCAL: UMA PERSPECTIVA CULTURAL E FAMILIAR EM NARRATIVAS

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    Maria Semirames de Almeida Queiroz

    2014-06-01

    Full Text Available Este estudo propõe compreender a dimensão da cultura e sua identidade na ação empreendedora e toda influência existente da empresa para o desenvolvimento local sendo assim, aqui, relatado por meio da história de vida, informações essenciais que designam melhor esse empreendimento, tendo como foco três empresas no ramo de panificação. Trata-se de entrevistas narrativas em empresas de pequeno porte, realizadas com os proprietários, respaldadas por meio de um referencial teórico.O estudo focalizou se essas novas técnicas e postura administrativas terão uma satisfação no resultado final, indicando seus pontos fortes e fracos concluindo então uma positividade entre o que a empresa oferece e os objetivos alcançados por ela.

  14. Evaluation of neurological complications using who warning signs for dengue disease severity

    International Nuclear Information System (INIS)

    Akmal, A.; Tauseef, A.; Akram, T.

    2015-01-01

    In 2009 a new classification of dengue was proposed by WHO Tropical Disease Research, which classifies dengue into dengue (D), dengue with warning signs (DW) and severe dengue (SD). This classification highlights the warning signs of dengue disease severity. Neurological complications are one of the most serious complications of dengue disease. This study was carried out to see association of neurological complications of dengue patients with WHO warning signs for dengue disease severity, and their outcome. Methods: It was a cross-sectional analytical study and included 180 diagnosed and registered cases of dengue hemorrhagic fever. The participants were subjected to a detailed clinical evaluation, laboratory assessment including blood counts, hematocrit, serology for dengue fever and sonography at 24 hours and 48 hours of their admission. Results: Twenty-six percent patients were suffering from neurological complications due to dengue. The warning signs for dengue disease severity like altered sensorium (85.5%, p=0.001), raised hematocrit (n=47, p=0.029), gall bladder wall thickening, pleural effusion and ascites on sonographic report (n=47, p=0.024), were strongly associated with the neurological complications. Conclusion: Our study reveals significant association of WHO warning signs for dengue disease severity with neurological complications of dengue disease. (author)

  15. Towards antiviral therapies for treating dengue virus infections.

    Science.gov (United States)

    Kaptein, Suzanne Jf; Neyts, Johan

    2016-10-01

    Dengue virus is an emerging human pathogen that poses a huge public health burden by infecting annually about 390 million individuals of which a quarter report with clinical manifestations. Although progress has been made in understanding dengue pathogenesis, a licensed vaccine or antiviral therapy against this virus is still lacking. Treatment of patients is confined to symptomatic alleviation and supportive care. The development of dengue therapeutics thus remains of utmost importance. This review focuses on the few molecules that were evaluated in dengue virus-infected patients: balapiravir, chloroquine, lovastatin, prednisolone and celgosivir. The lessons learned from these clinical trials can be very helpful for the design of future trials for the next generation of dengue virus inhibitors. Copyright © 2016 Elsevier Ltd. All rights reserved.

  16. Impacto económico del dengue y del dengue hemorrágico en el Estado de Zulia, Venezuela, 1997-2003 Economic impact of dengue and dengue hemorrhagic fever in the State of Zulia, Venezuela, 1997-2003

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    Germán Añez

    2006-05-01

    Full Text Available OBJETIVOS: Determinar los costos directos e indirectos asociados con