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Sample records for den diabetiske charcots

  1. Den diabetiske Charcots fod

    DEFF Research Database (Denmark)

    Christensen, T.M.; Yderstraede, K.; Ejskjaer, N.

    2008-01-01

    Charcot's arthropathy is a rare complication to diabetes with peripheral neuropathy. The diagnosis is based on a red, oedematous foot with 2 degrees C difference in skin temperature between the affected foot compared to the unaffected foot. The condition is characterised by fractures, dislocation...

  2. Charcot's osteoarthropathy

    African Journals Online (AJOL)

    destruction of bone and joint integrity affecting one or more ... confusion in diagnosis and treatment, Charcot's osteoarthropathy .... There may be no radiographic changes evident in the acute stages of the condition. ... Preventing further injury,.

  3. [Charcot's arthropathy

    DEFF Research Database (Denmark)

    Christensen, T.M.; Yderstraede, K.; Ejskjaer, N.

    2008-01-01

    Charcot's arthropathy is a rare complication to diabetes with peripheral neuropathy. The diagnosis is based on a red, oedematous foot with 2 degrees C difference in skin temperature between the affected foot compared to the unaffected foot. The condition is characterised by fractures, dislocation...

  4. George Sigerson: Charcot's translator.

    Science.gov (United States)

    Lyons, J B

    1997-04-01

    Senator George Sigerson (1836-1925), Dublin's first neurologist, was also a significant contributor to Anglo-Irish literature. His medical career and literary accomplishments are outlined, the focus of the article being Sigerson's friendly relationship with Charcot (with whom he corresponded), and whose Leçons sur les maladies du système nerveux he translated.

  5. Charcot and vascular Parkinsonism

    Directory of Open Access Journals (Sweden)

    Hélio A. G. Teive

    Full Text Available ABSTRACT Jean-Martin Charcot (1825-1893, recognized as the founder of Neurology and the first formal teacher of nervous system diseases, died on August 16, 1893, from acute pulmonary edema secondary to myocardial infarction. In his last years, there were several descriptions of his gait and posture disorders, suggesting the diagnosis of “lower-half parkinsonism” due to cerebrovascular disease.

  6. Imaging of Charcot foot

    International Nuclear Information System (INIS)

    Erlemann, Rainer; Schmitz, Annette

    2014-01-01

    The onset of a Charcot foot ist a feared complication of a long lasting diabetes mellitus. A peripheral neuropathy and continuous weight bearing of the foot subsequent to repeated traumas depict the conditions. There exist three types of a Charcot foot, an atrophic, a hypertophic and a mixed type. In early stages a differentiation from osteoarthritis is difficult. Subluxation or luxation within the Lisfranc's joint is typical. The joints of the foot could rapidly and extensively be destroyed or may present the morphology of a 'superosteoarthritis'. Often, soft tissue infections or osteomyelitis evolve from ulcers of the skin as entry points. Diagnosis of osteomyelitis necessitate MR imaging as plain radiography offers only low sensitivity for detection of an osteomyelitis. The existence of periosteal reactions is not a proof for osteomyelitis. Bone marrow edema and soft tissue edema also appear in a non infected Charcot foot. The range of soft tissue infections goes from cellulitis over phlegmon to abscesses. The ghost sign is the most suitable diagnostic criterion for osteomyelitis. In addition, the penumbra sign or the existence of a sinus tract between a skin ulcer and the affected bone may be helpful. (orig.)

  7. Imaging findings of charcot joint

    International Nuclear Information System (INIS)

    Meng Quanfei; Zhou Chunxiang; Chen Yingming; Jiang Bo

    2003-01-01

    Objective: To analyze the MRI characters of Charcot joint, and to evaluate the diagnostic value of X-ray, CT, and MRI on Charcot joint. Methods: Eight patients with 8 Charcot joints underwent X-ray, CT, and MR examinations. 6 of them had syringomyelia, 1 patient had injury of the spinal cord, and 1 case had diabetes. All 8 patients had sensory reduction or deficit in the sick extremities. Results: There were two types of Charcot joint, hypertrophic and atrophic. Radiographic and CT features of hypertrophic joint (n=3) showed hyperostotic osteosclerosis and mammoth osteophytes in the sick bones, periarticular ossification, and articular disorganization. Radiographic and CT features of atrophic joint (n=5) showed extensive bone resorption (destruction), periarticular debris, and articular disorganization. Main MRI features of Charcot joint included hydrarthrosis within joint capsule, thickened, loose, and elongated joint capsule with para-joint, peri-diaphysis, and inter-muscular extension in a pseudopodia pattern. The irregular joint capsule wall was presented as mild hypointensity on T 1 WI, slight hyper-intensity on T 2 WI, and was markedly enhanced after Gd-DTPA was administrated, which was considered as a characteristic manifestation of the lesion. Soft tissue mass containing hypo-intense stripes on both T 1 WI and T 2 WI was commonly noted adjacent to the involved joint. Conclusion: X-rays plain film is the first choice for the diagnosis of Charcot joint, and MRI is pretty useful in the diagnosis of Charcot joint

  8. The Charcot Foot in Diabetes

    Science.gov (United States)

    Frykberg, Robert G.; Armstrong, David G.; Boulton, Andrew J.M.; Edmonds, Michael; Van, Georges Ha; Hartemann, Agnes; Game, Frances; Jeffcoate, William; Jirkovska, Alexandra; Jude, Edward; Morbach, Stephan; Morrison, William B.; Pinzur, Michael; Pitocco, Dario; Sanders, Lee; Wukich, Dane K.; Uccioli, Luigi

    2011-01-01

    The diabetic Charcot foot syndrome is a serious and potentially limb-threatening lower-extremity complication of diabetes. First described in 1883, this enigmatic condition continues to challenge even the most experienced practitioners. Now considered an inflammatory syndrome, the diabetic Charcot foot is characterized by varying degrees of bone and joint disorganization secondary to underlying neuropathy, trauma, and perturbations of bone metabolism. An international task force of experts was convened by the American Diabetes Association and the American Podiatric Medical Association in January 2011 to summarize available evidence on the pathophysiology, natural history, presentations, and treatment recommendations for this entity. PMID:21868781

  9. Charcot's osteoarthropathy: An increased awareness of this ...

    African Journals Online (AJOL)

    Charcot's osteoarthropathy: An increased awareness of this condition may help in enabling an earlier diagnosis, instituting appropriate treatment, and preventing severe deformity and disability. T Johnson ...

  10. Imaging of Charcot foot; Bildgebung des Charcot-Fusses

    Energy Technology Data Exchange (ETDEWEB)

    Erlemann, Rainer; Schmitz, Annette [Helios Klinikum Duisburg, Helios St. Johannes Klinik, Duisburg (Germany). Inst. fuer Radiologie

    2014-03-15

    The onset of a Charcot foot ist a feared complication of a long lasting diabetes mellitus. A peripheral neuropathy and continuous weight bearing of the foot subsequent to repeated traumas depict the conditions. There exist three types of a Charcot foot, an atrophic, a hypertophic and a mixed type. In early stages a differentiation from osteoarthritis is difficult. Subluxation or luxation within the Lisfranc's joint is typical. The joints of the foot could rapidly and extensively be destroyed or may present the morphology of a 'superosteoarthritis'. Often, soft tissue infections or osteomyelitis evolve from ulcers of the skin as entry points. Diagnosis of osteomyelitis necessitate MR imaging as plain radiography offers only low sensitivity for detection of an osteomyelitis. The existence of periosteal reactions is not a proof for osteomyelitis. Bone marrow edema and soft tissue edema also appear in a non infected Charcot foot. The range of soft tissue infections goes from cellulitis over phlegmon to abscesses. The ghost sign is the most suitable diagnostic criterion for osteomyelitis. In addition, the penumbra sign or the existence of a sinus tract between a skin ulcer and the affected bone may be helpful. (orig.)

  11. Charcot-Marie-Tooth disease.

    LENUS (Irish Health Repository)

    Reilly, Mary M

    2011-03-01

    Charcot-Marie-Tooth (CMT) disease is the commonest inherited neuromuscular disorder affecting at least 1 in 2,500. Over the last two decades, there have been rapid advances in understanding the molecular basis for many forms of CMT with more than 30 causative genes now described. This has made obtaining an accurate genetic diagnosis possible but at times challenging for clinicians. This review aims to provide a simple, pragmatic approach to diagnosing CMT from a clinician\\'s perspective.

  12. Den gode handling og den gode grund

    DEFF Research Database (Denmark)

    Dehs, Jørgen

    1993-01-01

    Den tyske filosof Immanuel Kant er aktuel i dagens etik-debat. "Grundlæggelse af moralens metafysik".......Den tyske filosof Immanuel Kant er aktuel i dagens etik-debat. "Grundlæggelse af moralens metafysik"....

  13. Jean-Baptiste Charcot and Brazil

    Directory of Open Access Journals (Sweden)

    Hélio Afonso Ghizoni Teive

    2014-06-01

    Full Text Available Jean-Baptiste Charcot, a neurologist from the famous Salpêtrière school and a renowned maritime explorer, visited Brazil twice. The first visit was in 1903, when the first French Antarctic expedition, traveling aboard the ship Français, made a very short stopover in Recife, in the state of Pernambuco. The second took place in 1908, during the famous voyage of the Pourquoi Pas? to the Antarctic, when Charcot and his crew stayed in the city of Rio de Janeiro for eight days.

  14. CHARCOT-MARIE-TOOTH DISEASE

    Directory of Open Access Journals (Sweden)

    Lea Leonardis

    2003-09-01

    Full Text Available Background. Charcot-Marie-Tooth (CMT disease is a common inherited disorder of the peripheral nervous system. In our paper, different types of CMT are described with their typical clinical pictures, electrophysiological signs and molecular genetic studies. CMT is classified as demyelinative and axonal type and distal motor neuronopathy.Conclusions. CMT can be of autosomal dominant, recessive and X-linked inheritance. The most frequent form of CMT is the result of the dominantly inherited duplication of chromosome 17p11.2 and is marked as CMT1A. The same group involves also rare patients with point mutation in the peripheral myelin protein-22 gene. CMT1B is associated with point mutations in protein zero gene. CMT1C is linked to chromosome 16p13.1–12.3. Patients with point mutations in early growth response 2 gene (EGR2 are included in group CMT1D. The disease can be also inhereted X-linked (CMTX with the mutations in connexin-32 gene. In autosomal recessive inherited demyelinating polyneuropathies (CMT4, mutations are found in the myotubularin-related protein-2 (CMT4B, N-myc downstream-regulated gene 1 (CMT4D, EGR2 (CMT4E, and in the periaksin (CMT4F genes. In axonal inherited neuropathy, mutations are found in KIF1beta (CMT2A and in light neurofilament (CMT2E genes, other forms map to different chromosomal loci (CMT2B, CMT2D, CMT2F. Some suggestions for the diagnostic procedures of patients with CMT are given.

  15. Den gode argumentations anatomi

    DEFF Research Database (Denmark)

    Kock, Christian Erik J

    2013-01-01

    God argumentation har tre dimensioner: Den er faktuelt retvisende, den er relevant, og den er vægtig. Desværre slipper politikerne ofte af sted med mangelfuld argumentation fordi de forklæder den godt. Derfor får du her de vigtigste redskaber til at spotte uskikkene i politisk argumentation...

  16. Den umulige film

    DEFF Research Database (Denmark)

    Moestrup, Steffen Damkjær

    2014-01-01

    Den smertelige Sorg og Glæde fuldender en lang og glorværdig karriere for danske Nils Malmros. Den er en yderst vellykket film, fordi den forbliver usentimental om en skæbnesvanger dag i instruktørens liv.......Den smertelige Sorg og Glæde fuldender en lang og glorværdig karriere for danske Nils Malmros. Den er en yderst vellykket film, fordi den forbliver usentimental om en skæbnesvanger dag i instruktørens liv....

  17. Den store hysteri

    DEFF Research Database (Denmark)

    Norup, Lis

    2006-01-01

    Om hysterien som kunst og karriere, om kunsten at se og opføre symptomets sandhed, om Jean-Martin Charcot som neurosernes Napoléon og Blanche Wittmann som "la reine des hystériques" på La Salpêtrière i Paris i 1880'erne....

  18. Rosalie: the brazilian female monkey of Charcot Rosalie: a pequenina macaca brasileira de Charcot

    Directory of Open Access Journals (Sweden)

    Hélio A.G. Teive

    2005-09-01

    Full Text Available Jean-Martin Charcot, the father of Neurology, a very austere and reserved man that did not express affection freely for human being, had a profound affection to animals, particularly to a small female monkey, called "Rosalie", which came from Brazil and was a gift of Dom Pedro II to Charcot.Jean-Martin Charcot, considerado o pai da Neurologia, foi um homem de aspecto austero e reservado, que tinha dificuldades de expressar os seus sentimentos para outros seres humanos. Contudo ele tinha profunda afeição por animais, particularmente por uma pequena macaca, chamada de "Rosalie", oriunda do Brasil e que foi um presente dado a ele por Dom Pedro II.

  19. Den danske astronaut

    DEFF Research Database (Denmark)

    Jakobsen, Lars Sejersgård

    2014-01-01

    Undervisningsmateriale til mellemtrinnet om raketter, astronauter og rummet lavet for Planetariet i anledning af opsendelsen af den første danske astronaut, Andreas Mogensen, til Den Internationale Rumstation (ISS) i sensommeren 2015......Undervisningsmateriale til mellemtrinnet om raketter, astronauter og rummet lavet for Planetariet i anledning af opsendelsen af den første danske astronaut, Andreas Mogensen, til Den Internationale Rumstation (ISS) i sensommeren 2015...

  20. Den danske astronaut

    DEFF Research Database (Denmark)

    Jakobsen, Lars Sejersgård

    2014-01-01

    Undervisningsmateriale til udskolingen om raketter, astronauter og rummet lavet for Planetariet i anledning af opsendelsen af den første danske astronaut, Andreas Mogensen, til Den Internationale Rumstation (ISS) i sensommeren 2015......Undervisningsmateriale til udskolingen om raketter, astronauter og rummet lavet for Planetariet i anledning af opsendelsen af den første danske astronaut, Andreas Mogensen, til Den Internationale Rumstation (ISS) i sensommeren 2015...

  1. Den juridiske metode

    DEFF Research Database (Denmark)

    Hansen, Lone Louring; Werlauff, Erik

    DEN JURIDISKE METODE – en introduktion (2. udgave 2016) er en brugervenlig og praktisk bog om den juridiske metode. Den kan læses af både studerende og læsere uden juridiske forkundskaber. Bogen omhandler juridisk metode gennem 2000 år, retsområderne, udstedelse af retsregler, domstolene og deres...

  2. Den kommunikerende organisation

    DEFF Research Database (Denmark)

    Tække, Jesper

    2006-01-01

    samtidig tilbydes optimale muligheder for at få opfyldt individuelle behov og karrieremuligheder. For at en organisation skal kunne korrigere sig i forhold til de krav den konfronteres med, må der kunne fremstilles et adækvat billede af den. Det vil sige at dens faktiske kommunikationsprocesser må kunne...... drages frem i lyset på en måde så hensigtsmæssigheder og uhensigtsmæssigheder kan iagttages og selv blive objekt for reflekteret organisationskommunikation. Dette paper giver et udkast til en analysestrategi, hvormed der kan tegnes et billede af den enkelte organisation ud fra hvordan dens enkelte og...

  3. Clinical management of acute diabetic Charcot foot in Denmark

    DEFF Research Database (Denmark)

    Jansen, Rasmus Bo; Svendsen, Ole Lander; Kirketerp-Møller, Klaus

    2016-01-01

    INTRODUCTION: Charcot foot is a severe complication to diabetes mellitus and treatment involves several different clinical specialities. Our objective was to describe the current awareness, knowledge and treatment practices of Charcot foot among doctors who handle diabetic foot disorders. METHODS......: This study is based on a questionnaire survey sent out to healthcare professionals, primarily doctors, working with diabetic foot ulcers and Charcot feet in the public sector of the Danish healthcare system. RESULTS: The survey obtained a 52% response rate. A temperature difference of > 2 °C between the two...... and treatment practices of acute diabetic Charcot foot at diabetes foot clinics in Denmark. The responders seem to follow the international recommendations and guidelines on management of the acute diabetic Charcot foot, despite a lack of Danish guidelines. FUNDING: none. TRIAL REGISTRATION: not relevant....

  4. Autosomal recessive Charcot-Marie-Tooth neuropathy.

    Science.gov (United States)

    Espinós, Carmen; Calpena, Eduardo; Martínez-Rubio, Dolores; Lupo, Vincenzo

    2012-01-01

    Charcot-Marie-Tooth (CMT) disease, a hereditary motor and sensory neuropathy that comprises a complex group of more than 50 diseases, is the most common inherited neuropathy. CMT is generally divided into demyelinating forms, axonal forms and intermediate forms. CMT is also characterized by a wide genetic heterogeneity with 29 genes and more than 30 loci involved. The most common pattern of inheritance is autosomal dominant (AD), although autosomal recessive (AR) forms are more frequent in Mediterranean countries. In this chapter we give an overview of the associated genes, mechanisms and epidemiology of AR-CMT forms and their associated phenotypes.

  5. "Den onde kvinde"

    DEFF Research Database (Denmark)

    Holst, Søren

    2002-01-01

    Et af Dødehavsskrifterne, af den første udgiver kaldet "Den onde kvindes rænker" (4Q184), beskriver en svigefuld kvinde, der lokker fromme mænd i fordærv. Artiklen gennemgår tekstens fortolkningshistorie og påviser den rolle, det har spillet for læsningen, at teksten a priori er blevet opfattet s...

  6. Den inkluderende skole

    DEFF Research Database (Denmark)

    Hedegaard Hansen, Janne

    2009-01-01

    Artiklen tager afsæt i en forståelse af inklusion som den enkelte elevs ret til deltagelse i de eksisterende fællesskaber, forstået som de læringsrum, der bedst muligt tilgodeser den enkelte elevs særlige behov. I artiklen diskuteres hvilke nødvendige forandringer det fordrer i den pædagogiske pr...

  7. Den positive psykologis metoder

    DEFF Research Database (Denmark)

    Andersen, Frans Ørsted; Mørck, Line Lerche; Nissen, Poul Erik

    En antologi der giver en introduktion til en række af de metoder der anvendes til forskning, assessment, test, udviklingsarbejde og intervention indenfor den positive psykologi.......En antologi der giver en introduktion til en række af de metoder der anvendes til forskning, assessment, test, udviklingsarbejde og intervention indenfor den positive psykologi....

  8. Den katolske kirke

    DEFF Research Database (Denmark)

    Olden-Jørgensen, Sebastian

    2009-01-01

    En kort gennemgang af den katolske kirkes kirkerum, ritualer, selvforståelse og syn på andre kristne efterfulgt af 16 forskellige kildetekster til belysning og uddybning af emnerne. Bogen omfatter tilsvarende afsnit om de ortodokse kirker og om folkekirken. Den er beregnet til gymnasium og HF....

  9. Den levende sangfugl

    DEFF Research Database (Denmark)

    Bjerre, Thomas Ærvold

    2009-01-01

    Kronik om Harper Lee's roman "Dræb ikke en sangfugl" (1960) og den store indflydelse bog og film har haft på amerikansk kultur. Udgivelsesdato: 30. juli......Kronik om Harper Lee's roman "Dræb ikke en sangfugl" (1960) og den store indflydelse bog og film har haft på amerikansk kultur. Udgivelsesdato: 30. juli...

  10. Den moderate revolution

    DEFF Research Database (Denmark)

    Larsen, Bøje

    "normale" industrivirksomheder, men den er absolut set begrænset. Årsagerne til denne kun "moderate revolution" af organisationsformerne diskuteres: Er det fordi klassisk organisation og social nærkontakt er nødvendig i den nye økonomi, eller er det manglende fantasi og tryghedsbehov? Begge muligheder...

  11. Den iscenesatte virkelighed

    DEFF Research Database (Denmark)

    Bondebjerg, Ib

    2007-01-01

    Artiklen diskuterer den dramatiserede dokumentarismes forskellige genrer inden for film og tv. Det diskuteres hvor grænserne mellem fiktion og fakta går i journalistik og dokumentarisme. Hovedkonklusionen er, at den dramatiserede og iscenesatte dokumentarisme er en genre, der har en vigtig funktion...

  12. Den menneskelige plet

    DEFF Research Database (Denmark)

    Kjerkegaard, Stefan

    endog en selvstigmatisering, hvor selvfortællingen ikke hænger sammen. Der er tale om en menneskelig henvendelse inkorporeret i det, som litteraturen gør, snarere end i det, den siger. I den nye danske litteratur af eksempelvis Yahya Hassan, Asta Olivia Nordenhof eller Bjørn Rasmussen oplever man...

  13. Clinical management of acute diabetic Charcot foot in Denmark

    DEFF Research Database (Denmark)

    Jansen, Rasmus Bo; Svendsen, Ole Lander; Kirketerp-Møller, Klaus

    2016-01-01

    INTRODUCTION: Charcot foot is a severe complication to diabetes mellitus and treatment involves several different clinical specialities. Our objective was to describe the current awareness, knowledge and treatment practices of Charcot foot among doctors who handle diabetic foot disorders. METHODS...... for offloading (83%). All centres use some form of a multidisciplinary team, with the most common permanent members being orthopaedic surgeons (71%), wound specialist nurses (76%), podiatrists (65%), endocrinologists (47%) and diabetes specialist nurses (41%). CONCLUSION: We conducted a survey of the diagnosis...

  14. Den Gode Historie

    DEFF Research Database (Denmark)

    Mogensen, T.E.

    den nysgerrige læser af trilogien. Den kan beses og bestilles på: www.universitypress.dk/DK/detail.php?token=73278292116&R=8778387078&N=nej ELLER KØB DEN DIREKTE HOS MIG: SLAGTILBUD 100 kr. (inkl. porto og forsendelse)!                            Henvendelse pr. e-mail til tine.engel@gmail.com...

  15. Diagnosis of Charcot-Marie-Tooth Disease

    Directory of Open Access Journals (Sweden)

    Isabel Banchs

    2009-01-01

    Full Text Available Charcot-Marie-Tooth (CMT disease or hereditary motor and sensory neuropathy (HMSN is a genetically heterogeneous group of conditions that affect the peripheral nervous system. The disease is characterized by degeneration or abnormal development of peripheral nerves and exhibits a range of patterns of genetic transmission. In the majority of cases, CMT first appears in infancy, and its manifestations include clumsiness of gait, predominantly distal muscular atrophy of the limbs, and deformity of the feet in the form of foot drop. It can be classified according to the pattern of transmission (autosomal dominant, autosomal recessive, or X linked, according to electrophysiological findings (demyelinating or axonal, or according to the causative mutant gene. The classification of CMT is complex and undergoes constant revision as new genes and mutations are discovered. In this paper, we review the most efficient diagnostic algorithms for the molecular diagnosis of CMT, which are based on clinical and electrophysiological data.

  16. Charcot-Marie-Tooth disease in Denmark

    DEFF Research Database (Denmark)

    Vaeth, Signe; Vaeth, Michael; Andersen, Henning

    2017-01-01

    OBJECTIVES: Charcot-Marie-Tooth disease (CMT) is the most common inherited disorder of the peripheral nervous system, yet no studies have compared the mortality in patients with CMT with that of the general population, and prevalence estimates vary considerably. We performed a nationwide register....... The prevalence was estimated by 31 December 2012, and the incidence rate was calculated based on data from 1988 to 2012. We calculated a standardised mortality ratio (SMR) and an absolute excess mortality rate (AER) stratified according to age categories and disease duration. RESULTS: A total of 1534 patients...... a significantly higher SMR in cases below 50 years of age, and in cases with disease duration of more than 10 years. CONCLUSIONS: We found a reduced life expectancy among patients diagnosed with CMT. To our knowledge, this is the first study of CMT to use nationwide register-based data, and the first to report...

  17. Charcots artropati som årsag til hypoparatyroid hyperkalcæmi

    DEFF Research Database (Denmark)

    Engberg, Susanne; Jensen, Jens-Erik Beck; Kønig, Karen Bay

    2012-01-01

    hyperthyroidism. Charcots arthropathy is not a recognized cause of hypoparathyroid hypercalcaemia, but the mechanism might be increased boneresorption. We recommend that Charcots arthropathy is considered a cause of hypoparathyroid hypercalcaemia in patients with diabetic neuropathy....

  18. Bone mineral density in diabetes mellitus patients with and without a Charcot foot

    DEFF Research Database (Denmark)

    Christensen, Tomas M; Bülow, Jens; Simonsen, Lene

    2010-01-01

    To measure bone mineral density in patients with diabetes mellitus and the complication Charcot osteoarthropathy (CA).......To measure bone mineral density in patients with diabetes mellitus and the complication Charcot osteoarthropathy (CA)....

  19. Den positive psykologis metoder

    DEFF Research Database (Denmark)

    Bogen introducerer til de mange metoder, som anvendes i positiv psykologi. dette sker ud fra en reflekteret tilgang, der ligeledes rummer bidrag fra kritisk psykologi med det formål at nuancere den positive psykologis forståelser...

  20. I den sidste time

    DEFF Research Database (Denmark)

    Norup, Lis

    : Dekadencens teori. Arthur William Symons: Dekadencens litteratur. Oscar Wilde: Kritikeren som kunstner) Noter I tekster skrevet i 1800-tallet udfoldes dekadencekunsten som den forfinede sensibilitets, de forstyrrede sansers og det oprevne sinds digtning. Med litteraturhenvisninger....

  1. Denver District Laboratory (DEN)

    Data.gov (United States)

    Federal Laboratory Consortium — Program CapabilitiesDEN-DO Laboratory is a multi-functional laboratory capable of analyzing most chemical analytes and pathogenic/non-pathogenic microorganisms found...

  2. Den professionelle samtale

    DEFF Research Database (Denmark)

    Herskind, Mia

    2012-01-01

    , som et sådant perspektiv indebærer. Kapitlet tager afsæt i forskellige typer af professionelle samtaler (interview, supervision og terapi), hvor den professionelle stiller spørgsmål og er til stede på måder, så også den prærefleksive og kropslige-sanselige fortælling bliver en del af samtalen. Det...

  3. Den signede dag

    DEFF Research Database (Denmark)

    Balslev-Clausen, Peter

    2010-01-01

    Artiklen gennemgår de tre middelalderlige versioner af den fællesnordiske dagvise fra 14. århundrede og gør rede for salmens tekst- og receptionshistorie i Dansk tradition.......Artiklen gennemgår de tre middelalderlige versioner af den fællesnordiske dagvise fra 14. århundrede og gør rede for salmens tekst- og receptionshistorie i Dansk tradition....

  4. Jean-Martin Charcot's Role in the 19th Century Study of Music Aphasia

    Science.gov (United States)

    Johnson, Julene K.; Lorch, Marjorie; Nicolas, Serge; Graziano, Amy

    2013-01-01

    Jean-Martin Charcot (1825-93) was a well-known French neurologist. Although he is widely recognized for his discovery of several neurological disorders and his research into aphasia, Charcot's ideas about how the brain processes music are less well known. Charcot discussed the music abilities of several patients in the context of his "Friday…

  5. Freud with Charcot: Freud's discovery and the question of diagnosis.

    Science.gov (United States)

    Lepoutre, Thomas; Villa, François

    2015-04-01

    Although Charcot's seminal role in influencing Freud is widely stated, although Freud's trip to Paris to study with Charcot is well recognized as pivotal in his shift from neurological to psychopathological work, a key fact of the Freudian heuristic remains largely underestimated: namely, that Freud's psychopathological breakthrough, which gave birth to psychoanalysis, cannot be separated from his 'diagnostic preoccupation', which is a crucial and at times the first organizing principle of his earliest writings. The purpose of this article is therefore to reopen the question of diagnosis by following its development along the path leading from Charcot to Freud. The authors demonstrate that Freud's careful attention to diagnostic distinctions follows strictly in the direction of Charcot's 'nosological method'. More importantly, the article intends to identify the precise way in which his ideas operate in Freud's own work, in order to understand how Freud reinvests them to forge his own nosological system. If the authors trace the destiny of Charcot's lessons as they reach Freud's hands, it is the importance granted to mixed neuroses in Freud's psychopathology that allows them to pinpoint the role played by the diagnostic process in the rationality of psychoanalysis. Copyright © 2014 Institute of Psychoanalysis.

  6. Etiology, pathophysiology and classifications of the diabetic Charcot foot

    Science.gov (United States)

    Papanas, Nikolaos; Maltezos, Efstratios

    2013-01-01

    In people with diabetes mellitus, the Charcot foot is a specific manifestation of peripheral neuropathy that may involve autonomic neuropathy with high blood flow to the foot, leading to increased bone resorption. It may also involve peripheral somatic polyneuropathy with loss of protective sensation and high risk of unrecognized acute or chronic minor trauma. In both cases, there is excess local inflammatory response to foot injury, resulting in local osteoporosis. In the Charcot foot, the acute and chronic phases have been described. The former is characterized by local erythema, edema, and marked temperature elevation, while pain is not a prominent symptom. In the latter, signs of inflammation gradually recede and deformities may develop, increasing the risk of foot ulceration. The most common anatomical classification describes five patterns, according to the localization of bone and joint pathology. This review article aims to provide a brief overview of the diabetic Charcot foot in terms of etiology, pathophysiology, and classification. PMID:23705058

  7. Surgical Reconstruction of Charcot Foot Neuroarthropathy, a Case Based Review

    Directory of Open Access Journals (Sweden)

    Tomáš Kučera

    2014-01-01

    Full Text Available Our case-based review focuses on limb salvage through operative management of Charcot neuroarthropathy of the diabetic foot. We describe a case, when a below-knee amputation was considered in a patient with chronic Charcot foot with a rocker-bottom deformity and chronic plantar ulceration. Conservative treatment failed. Targeted antibiotic therapy and operative management (Tendo-Achilles lengthening, resectional arthrodesis of Lisfranc and midtarsal joints, fixation with large-diameter axial screws, and plaster cast were performed. On the basis of this case, we discuss options and drawbacks of surgical management. Our approach led to healing of the ulcer and correction of the deformity. Two years after surgery, we observed a significant improvement in patient’s quality of life. Advanced diagnostic and imaging techniques, a better understanding of the biomechanics and biology of Charcot neuroarthropathy, and suitable osteosynthetic material enables diabetic limb salvage.

  8. Den udenlandske udtales finurligheder

    DEFF Research Database (Denmark)

    Davidsen-Nielsen, Niels

    2017-01-01

    Eftertanken. Det er ikke altid nemt at tale om store, internationale kunstnere som Mozart eller Gabriel García Márquez. For hvordan skal den danske mund udtale z'et i Mozart og lægge trykket i García?......Eftertanken. Det er ikke altid nemt at tale om store, internationale kunstnere som Mozart eller Gabriel García Márquez. For hvordan skal den danske mund udtale z'et i Mozart og lægge trykket i García?...

  9. What lessons can history teach us about the Charcot foot?

    Science.gov (United States)

    Sanders, Lee J

    2008-01-01

    Regrettably, physicians today receive very little instruction in the history of medicine. Most health care providers have a very limited, contemporary knowledge of the condition that we know of as the Charcot foot. Yet, historical concepts of the pathogenesis and natural history of this condition provide us with important lessons that enhance our understanding, recognition, and management of this rare but debilitating neurogenic arthropathy. It is my belief that knowledge of the history of medicine provides us with a better understanding of present-day issues and clearer vision as we look to the future. This article describes some of the important lessons learned from the history of the Charcot foot.

  10. Den sundhedsvidenskabelige opgave

    DEFF Research Database (Denmark)

    Lindahl, Marianne Pia; Juhl, Carsten Bogh

    troværdigheden af sine resultater. Bogen er opdateret, så den refererer til Microsoft Office 2013, og giver instruktioner og tips til: • Hvordan man bruger Word til hjælp med indholdsfortegnelse, overskrifter og korrektur • Hvordan man bruger Word til hjælp med diagrammer og tabeller• Hvordan man bruger Excel...

  11. Den postmoderne konstruktivismes inkongruenser

    DEFF Research Database (Denmark)

    Cristoffanini, Pablo Rolando

    2011-01-01

    europæiske intellektuelle og akademikere gjorde teorierne og ideerne om underudvikling og afhængighed, der stammede fra Latinamerika, til deres egne. Også i den sidste tid har latinamerikanske intellektuelle, som fx Nestor García Canclini, haft indflydelse i Europa og USA med sin teori om hybriditet og...

  12. Den moderne bevidstheds katedral

    DEFF Research Database (Denmark)

    Ostenfeld Pedersen, Simon

    2002-01-01

    Interview med idéhistorikeren Dorthe Jørgensen der under overskriften ”Den moderne bevidstheds katedral” blotlægger hendes mangeårige arbejde med Hegel, og hvor hun giver en række relevante bud på en aktualiserende Hegel-læsning centreret omkring felter som metafysik, historiefilosofi og æstetik....

  13. Den kaotiske organisation

    DEFF Research Database (Denmark)

    Helms, Niels Henrik

    2006-01-01

    Præsentation af den britiske organisationsteoretiker Ralph Stacey: Stacey mener samlet, at organisationer ikke skal ses som systemer, der opstår, når individer interagerer med hinanden. Det er selve interaktionen, der er organisationen. Staceys kernebegreb er temporære processer. Når vi interager...

  14. Den professionelle rolle

    DEFF Research Database (Denmark)

    Præstegaard, Jeanette; Sørensen, Kirsten

    2009-01-01

    Psykiatri er den disciplin indenfor lægevidenskaben, der beskæftiger sig med at forebygge, diagnosticere og helbrede psykiske sygdomme. I “Lærebog i psykiatri” giver Lene Nyboe sig bud på ergoterapeutisk og fysioterapeutisk kernefaglighed indenfor det psykiatriske område. Behandlingstraditionerne...

  15. Den skjulte religion

    DEFF Research Database (Denmark)

    Rubow, Cecilie

    2001-01-01

    Kulturbegrebet har længe været genstand for kritik i human- og samfundsvidenskaberne. Studier i Vesteuropa, blandt andet i det danske folkekirkelige felt, viser, at der er flere paralleller at drage til religionsbegrebet. Der er behov for at bevæge sig væk fra den rutineprægede beskrivelse og gøre...

  16. Den danske regionskonstruktion

    DEFF Research Database (Denmark)

    Klausen, Kurt Klaudi; Christoffersen, Henrik

    Region Midtjylland er i centrum for analysen men den omfatter også regionsdannelsen i almindelighed. Der anlægges i analysen på samme tid et politologisk, organisationsteoretisk og økonomisk resonnement. Regionsdannelsen finder sted på baggrund af de setup Strukturreformen har sat, men udfoldes p...

  17. Efterskrift til den reviderede udgave

    DEFF Research Database (Denmark)

    Nielsen, Carsten Fogh

    2017-01-01

    Opsummering af tendenser og udviklingstræk inden for den nyere forskning i Kants historiefilosofi.......Opsummering af tendenser og udviklingstræk inden for den nyere forskning i Kants historiefilosofi....

  18. Den sociale stofmisbrugsbehandling. Del 6

    DEFF Research Database (Denmark)

    Sørensen, Maren; Buchholt Pedersen, Katrine

    Dette er den sjette delrapport i en rapportserie om den sociale stofmisbrugsbehandling i Danmark. Rapportserien bygger på en omfattende undersøgelse, der blev fortaget i perioden december 2007 til maj 2009. Denne delrapport stiller skarpt på resultaterne af den sociale stofmisbrugsbehandling i Da...

  19. Dannelsen af den ansvarlige elev

    DEFF Research Database (Denmark)

    Larsen, Jesper

    2010-01-01

    Denne artikel handler om den del af lærergerningen, der har at gøre med udarbejdelse af elevplaner. Der tages udgangspunkt i en foucaultsk forståelse, hvor beskrivelsen af den enkelte elev udtrykker et særligt normativt ideal om, hvilke former for elevhed der er de ønskværdige i den danske...

  20. Den sociale stofmisbrugsbehandling. Del 4

    DEFF Research Database (Denmark)

    Sørensen, Maren

    Dette er den fjerde delrapport i en rapportserie om den sociale stofmisbrugsbehandling i Danmark. Rapportserien bygger på en omfattende undersøgelse, der blev fortaget i perioden december 2007 til maj 2009. Denne delrapport stiller skarpt på kvalitetsudvikling og kvalitetsstandarder i den sociale...

  1. Mortality associated with acute Charcot foot and neuropathic foot ulceration

    NARCIS (Netherlands)

    van Baal, Juliette; Hubbard, Richard; Game, Fran; Jeffcoate, William

    2010-01-01

    To compare the mortality of patients with an acute Charcot foot with a matched population with uninfected neuropathic foot ulcers (NFUs). Data were extracted from a specialist departmental database, supplemented by hospital records. The findings were compared with the results of earlier populations

  2. Charcot-Marie-Tooth disease type 1A

    DEFF Research Database (Denmark)

    Hertz, Jens Michael; Børglum, A D; Brandt, C A

    1994-01-01

    Charcot-Marie-Tooth disease type 1A (CMT1A) is an autosomal dominant peripheral neuropathy associated with a DNA duplication on chromosome 17p11.2-p12 in the majority of cases. Most of the sporadic cases are due to a de novo duplication. We have screened for this duplication in 11 Danish patients...

  3. dens festival

    DEFF Research Database (Denmark)

    Agerholm, Frank Juul

    2012-01-01

    Som den italienske antropolog og folklorist Alessandro Falassi gør opmærksom på i antologien Time out of Time: Essays on the Festival, så er det sparsomt, hvad der er gjort af teoretiske forsøg på definere, hvad en festival er. Det står altså skidt til med et begreb om festivalen, og dette endog...... til trods for, at der er forsket i festivalen som fænomen siden det 19. århundrede – tilmed inden for en række forskellige faglige discipliner såsom religionsvidenskab, sociologi, antropologi, folklore m.fl. Endnu mere sparsomt må det vel så også stå til med bud på, hvad fødens festival er for en...

  4. Den der ser, er den, der ses

    DEFF Research Database (Denmark)

    Bjerrum, Troels

    2010-01-01

    Udgangspunktet for afhandlingen er at undersøge, hvordan unge udsatte mennesker kan opnå personlig forandring ved hjælp af åndedrætstræning og meditation. Afhandlingen indleder med at beskrive de unges liv i en globalisering. Mange unge mennesker uden en social ansvarlig baggrund har ikke lært...... at foretage sig nødvendige samfundsmæssige valg. På grund af nederlag i hjem, skole, uddannelse og erhverv søger unge fællesskaber i ligestillede miljøer svarende til egen negative forventningspraksis. Den unge praktiserer en vanedannende negativ livsførelse, som eskalerer til yderligere socialt forfald. Unge......, der har levet i kriminalitet, misbrug og medmisbrug i lang tid, vil ikke være i stand til at realisere sig positivt pga. en personlig indgroet diskvalificerende forestilling. Afhandlingen forklarer, hvorledes negative oplevelser forbliver spændinger i menneskers krop. Teorier af Maurice Merleau...

  5. Den amoralske liberalisme

    DEFF Research Database (Denmark)

    Skov, Christian Houlberg

    2011-01-01

    Fra både højre og venstre skydes der i disse år med skarpt mod liberalismen; i denne artikel anmelder Christian H. Skov Against Liberalism af John Kekes, der søger at påvise liberalismens mangler fra et logisk-filosofisk udgangspunkt, med den grundlæggende påstand, at liberalismens to mål, at fre......, at fremelske autonomi og begrænse ondskab, er uforenelige....

  6. Den gamle verdens magi

    DEFF Research Database (Denmark)

    Holck, Jakob Povl

    I denne bog præsenterer forskningsbibliotekar cand.mag., ph.d. Jakob Povl Holck sjældne bøger og andre biblioteksmaterialer fra Herlufsholm-samlingen på Syddansk Universitetsbibliotek i Odense. Bogens form udgør en mosaik af værker i tekst og især billeder med speciel vægt på ’den videnskabelige ...

  7. A contribuição de Charcot para o estudo da síndrome de Tourette Charcot's contribution to the study of Tourette's syndrome

    Directory of Open Access Journals (Sweden)

    Hélio A.G. Teive

    2008-12-01

    Full Text Available Revisamos a história da síndrome de Tourette, com ênfase a contribuição de Jean-Martin Charcot.We review the history of Tourette syndrome, emphasizing the contribution of Jean-Martin Charcot.

  8. An Analysis of the Symptomatic Domains Most Relevant to Charcot Marie Tooth Neuropathy (CMT) Patients

    Science.gov (United States)

    2017-06-09

    Charcot Marie Tooth Disease (CMT); Hereditary Sensory and Motor Neuropathy; Nerve Compression Syndromes; Tooth Diseases; Congenital Abnormalities; Genetic Diseases, Inborn; Heredodegenerative Disorders, Nervous System

  9. Den Danske Netordbog

    DEFF Research Database (Denmark)

    Bergenholtz, Henning; Vrang, Vibeke; Almind, Richard

    Denne danske ordbog er primært tænkt som hjælpeværktøj i forbindelse med tvivl og usikkerhed, når man skriver en dansk tekst. Den Danske Netordbog er en yderst omfattende ordbog med mere end 110.000 forskellige opslagsord og en lang række oplysninger, herunder grammatik, betydning, synonym (ord m...... samme betydning), antonym (ord med modsat betydning), orddannelse (i hvilke andre ord det pågældende ord er en del af), kollokationer (ordforbindelser), idiomer (fast udtryk med en særlig betydning) og ordsprog og citater....

  10. Den humane teknologi

    DEFF Research Database (Denmark)

    Fausing, Bent

    2008-01-01

    Artiklen undersøger hverdagsæstetikkens forestillinger om teknologi i tv-reklamer, nærmere bestemt to mobiltelefoner fra Nokia. Nokias slogan er som bekendt: "Nokia -connecting people". Hvilken funktion tilskrives denne succes-teknologi via billeder, narrativer, lyde, interaktioner og affekter...... personifikation eller antropomorfisering er vigtig for branding af den ny teknologi. Teknologien bliver betragtet som skaber af en teknotranscendens mod en mere kvalificeret humanitet, som er i kontakt med fundamentale humane værdier som intuition, fantasi og sansning. Det drejer sig i alle tilfælde om kvaliteter...

  11. Den bureaukratiske elite

    DEFF Research Database (Denmark)

    Krarup, Troels

    2012-01-01

    Artiklen kortlægger ved korrespondanceanalyse karriereveje for 122 topembedsmænd i centraladministrationen. Artiklen har tre anliggender: 1) at opdatere og nuancere billedet af den bureaukratiske elite i Danmark, som det kendes fra tidligere politologiske studier; 2) at positionere analysen i et...... europæisk perspektiv og i forhold til en anden dansk elite, topdirektører; og 3) at eksemplificere visse teoretiske og metodiske fordele ved felt- og korrespondanceanalyser uden så nær anknytning til Bourdieus sociologi, som det almindeligvist ses i magtstudier, bl.a. ved at introducere brug af idealtyper...

  12. Den økonomiske verdensorden

    DEFF Research Database (Denmark)

    Ougaard, Morten

    2016-01-01

    . Men det er ikke en statisk orden, den har udviklet og forandret sig gennem de sidste 70 år, og det er ikke første gang, den står over for betydelige udfordringer. Derfor er det instruktivt at kaste et blik bagud. De nuværende vanskeligheder skal ses på baggrund af den historie, der har skabt dem, og...

  13. Den farefulde gyngeleg

    DEFF Research Database (Denmark)

    Karoff, Helle Skovbjerg

    2014-01-01

    I lyset af samtidens diskussioner af sikkerhed og det farefulde (Sandseter, 2009) i børns fysiske leg skal artiklen udforske forholdet mellem den interaktive gynge SON-X, legeaktiviteterne og det farefulde. Formålet er at undersøge, hvordan børn håndterer det farefulde og sikkerhed i deres gyngeleg......, og det formål skal udforskes gennem stemningsperspektivet (Karoff, 2010, 2013). Stemningsperspektivet er et livsfilosofisk perspektiv på legeaktiviteterne (Schiller, 1996, Nietzsche, 1996, Huizinga, 1956, Gadamer, 1966), der anskuer legeaktiviteterne som praksis, der har til formål at sætte de...... deltagende i en særlig stemning. En stemning er en måde at være til på i verden, der præges af åbenhed over for øjeblikket, over for andre mennesker og over for nye muligheder for at skabe mening (Heidegger, 2005). Afslutningsvist skal artiklen reflektere over teknologiens rolle – eksemplificeret med den...

  14. Sygehusene i den islamiske verden i den klassiske tid

    OpenAIRE

    Provencal, Philippe

    2014-01-01

    Et af de væsentlige punkter, hvor den arabiske medicin udmærker sig i forhold til tidligere tiders medicin var i oprettelsen og organiseringen af regelrette sygehuse. Artiklen beskriver sygehusenes oprindelse, plads og funktion i den klassiske arabiske kultur (750-1500)

  15. 'Den danske model' som tema

    DEFF Research Database (Denmark)

    Caraker, Emmett; Juul, Ida; Klindt, Mads Peter

    2012-01-01

    Tidsskrift for Arbejdsliv vol. 14, nr. 2, 5-8. Tema: 'Den danske model'. Redigeret af Emmett Caraker, Ida Juul, Mads peter Klindt & Jens Lind. 2011. København. 128 s.......Tidsskrift for Arbejdsliv vol. 14, nr. 2, 5-8. Tema: 'Den danske model'. Redigeret af Emmett Caraker, Ida Juul, Mads peter Klindt & Jens Lind. 2011. København. 128 s....

  16. Dorte Nors "Den store tomat"

    DEFF Research Database (Denmark)

    Michelsen, Jimmi

    2017-01-01

    Tekstgennemgang og undervisningsforløb til Dorte Nors "Den store tomat". Undervisningsforløbet er henvendt til elever i folkeskolens udskoling......Tekstgennemgang og undervisningsforløb til Dorte Nors "Den store tomat". Undervisningsforløbet er henvendt til elever i folkeskolens udskoling...

  17. Hyldest til den destruktive feminist

    DEFF Research Database (Denmark)

    Hansen, Brian Benjamin

    2017-01-01

    Den destruktive feminist er kommet for at uddele røvfulde og slikkepinde – og hun er netop løbet tør for slikkepinde.......Den destruktive feminist er kommet for at uddele røvfulde og slikkepinde – og hun er netop løbet tør for slikkepinde....

  18. Den medicinal-industrielle logik

    DEFF Research Database (Denmark)

    Børsen, Tom

    2008-01-01

    Et kig på medicinalindustrien og den logik der styrer udviklingen af nye lægemidler. Antagelsen er, at der også eksisterer et medicinalindustrielt kompleks, bestående af ledende industrifolk, læger, forskere og regeringsembedsmænd, der alle har kommercielle interesser i den herskende lægemiddeltæ...

  19. Den narrative tilgang

    DEFF Research Database (Denmark)

    Bo, Inger Glavind

    2016-01-01

    I kapitlet gennemgås en socialkonstruktivistisk forståelse af narrativer. I kapitlet vil jeg gennemgå centrale teoretiske pointer, der samlet set er grundlæggende for en social konstruktivistisk forståelse af narrativer for herved at udfolde forståelsen af den narrative tilgang og desuden...... tydeliggøre, hvordan tilgangen er forbundet med en særlig forståelse af identitetsskabelse. Der er tale om pointer der almindeligvis forbindes med ”små fortællinger” i form af længere identitetsfortællinger og narrative interviews. Kapitlet gennemgår således centrale inspirationskilder og teoretiske pointer...

  20. Phenotypic spectrum of dynamin 2 mutations in Charcot-Marie-Tooth neuropathy

    NARCIS (Netherlands)

    Claeys, Kristl G.; Züchner, Stephan; Kennerson, Marina; Berciano, José; Garcia, Antonio; Verhoeven, Kristien; Storey, Elsdon; Merory, John R.; Bienfait, Henriette M. E.; Lammens, Martin; Nelis, Eva; Baets, Jonathan; de Vriendt, Els; Berneman, Zwi N.; de Veuster, Ilse; Vance, Jefferey M.; Nicholson, Garth; Timmerman, Vincent; de Jonghe, Peter

    2009-01-01

    Dominant intermediate Charcot-Marie-Tooth neuropathy type B is caused by mutations in dynamin 2. We studied the clinical, haematological, electrophysiological and sural nerve biopsy findings in 34 patients belonging to six unrelated dominant intermediate Charcot-Marie-Tooth neuropathy type B

  1. Den iscenesatte folkelighed

    Directory of Open Access Journals (Sweden)

    Néstor Garcia Canclini

    1994-09-01

    Full Text Available Hvad er "det folkelige" og hvad er "folkekultur"? Néstor Garcia Canclini har i denne artikel sat sig for at dekonstruere begrebet "det folkelige" og beskrive den måde, forskellige grupper bruger og misbruger begrebet på. Han analyserer tre fremherskende idéer om folkelighed: folkloristernes romantiske idé om det oprindelige, der blev ødelagt af massekulturen, massemediernes popularitetsbegreb og endelig populisternes - både de højre- og venstreorienteredes - iscenesættelse af folkeligheden. Desuden ser han på to marxistiske skolers opfattelse af forholdet mellem de dominerende og undertrykte klasser og forskellige definitioner af folkelig- hed. Ligesom Anamaria Fadul argumenterer Canclini for nødvendigheden af en ny, tværdiciplinær forskning, som opfanger kompleksitet og flerty- digheder i forholdet mellem de undertrykte og dominerende og ser "det folkelige" som en tragisk komedie med modsætninger og flertydighed snarere end en evigt fremadskrivende episk fortælling. Artiklen er en forkortet udgave af kapitel 5 i Canclinis bog fra 1989: "Culturas Hibridas - Estrategias para entrat y salir de la modernidad. Mexico: Grijalbo.

  2. Charcot-Marie-Tooth disease complicating type 2 diabetes.

    LENUS (Irish Health Repository)

    Win, Htet Htet Ne

    2012-02-01

    Although both conditions are relatively common, there are very few descriptions of type 2 diabetes mellitus coexisting with Charcot-Marie-Tooth disease (CMT). This case report and literature review describes a 53-year-old Irish man who presented with type 2 diabetes and significant neuropathy, and who was subsequently diagnosed with CMT type 1A. This case report will also discuss how to differentiate diabetic neuropathy from a progressive hereditary neuropathy and how coexistence aggravates the progression of neuropathy thus necessitating early diagnosis.

  3. Charcot-marie-tooth disease complicating type 2 diabetes.

    LENUS (Irish Health Repository)

    Win, Htet Htet Ne

    2011-07-01

    Although both conditions are relatively common, there are very few descriptions of type 2 diabetes mellitus coexisting with Charcot-Marie-Tooth disease (CMT). This case report and literature review describes a 53-year-old Irish man who presented with type 2 diabetes and significant neuropathy, and who was subsequently diagnosed with CMT type 1A. This case report will also discuss how to differentiate diabetic neuropathy from a progressive hereditary neuropathy and how coexistence aggravates the progression of neuropathy thus necessitating early diagnosis.

  4. Sarcopenia and body composition in diabetic Charcot osteoarthropathy

    DEFF Research Database (Denmark)

    Jansen, Rasmus Bo; Christensen, Tomas Møller; Bülow, Jens

    2015-01-01

    : Cross-sectional case-control study of people with diabetes with acute or chronic Charcot osteoarthropathy, matched with otherwise healthy people with diabetes. A total of 49 subjects (distribution ~1:1) had a total body DXA-scanning, measuring appendicular lean mass, android/gynoid and truncal...... (24.5-31.9%), whereas there were no significant differences found between the groups (P=0.065). Neither truncal/total fat percent nor android/gynoid fat percent ratios showed differences between the groups. CONCLUSION: To our knowledge, this is the first published dataset investigating body...

  5. Diabetic charcot neuroarthropathy of the foot and ankle with osteomyelitis.

    Science.gov (United States)

    Ramanujam, Crystal L; Stapleton, John J; Zgonis, Thomas

    2014-10-01

    One of the most devastating foot and/or ankle complications in the diabetic population with peripheral neuropathy is the presence of Charcot neuroarthropathy (CN). In recent years, diabetic limb salvage has been attempted more frequently as opposed to major lower extremity amputation for CN of the foot and ankle with ulceration and/or deep infection. Treatment strategies for osteomyelitis in the diabetic population have evolved. This article reviews some of the most common surgical strategies recommended for the diabetic patient with CN of the foot and/or ankle and concomitant osteomyelitis. Copyright © 2014 Elsevier Inc. All rights reserved.

  6. Medical Imaging in Differentiating the Diabetic Charcot Foot from Osteomyelitis.

    Science.gov (United States)

    Short, Daniel J; Zgonis, Thomas

    2017-01-01

    Diabetic Charcot neuroarthropathy (DCN) poses a great challenge to diagnose in the early stages and when plain radiographs do not depict any initial signs of osseous fragmentation or dislocation in a setting of a high clinical index of suspicion. Medical imaging, including magnetic resonance imaging, computed tomography, and advanced bone scintigraphy, has its own unique clinical indications when treating the DCN with or without concomitant osteomyelitis. This article reviews different clinical case scenarios for choosing the most accurate medical imaging in differentiating DCN from osteomyelitis. Copyright © 2016 Elsevier Inc. All rights reserved.

  7. Den tidslogiske analyse af determinismeproblemet

    DEFF Research Database (Denmark)

    Øhrstrøm, Peter

    2010-01-01

    Artiklen diskuterer den filosofiske tidslogik med særligt henblik på A.N. Priors bidrag hertil. Det logiske determinismeproblem benyttes som gennemgående eksempel. Det vises endvidere, hvordan tidslogikken kan udnyttes til at analysere de logisk mulige positioner i en videnskabelig eller videnska...... videnskabsteoretisk debat. Her bruges den videnskabshistorisk betydende diskussion mellem Charles Darwin og Asa Gray som eksempel....

  8. Ensretning i den internationale skatteret

    DEFF Research Database (Denmark)

    Schmidt, Peter Koerver; Bundgaard, Jakob

    2015-01-01

    I lyset af den seneste tids begivenheder (herunder særligt Luxleaks-sagerne) og tiltag på den internationale skattescene ses der i artiklen nærmere på en række af de forhold, som trækker i retning af øget ensretning af selskabsskattereglerne i store dele af verden. Det gøres gældende, at staternes...

  9. Den guddommelige æstetik

    DEFF Research Database (Denmark)

    Moutamid, Mina El

    2007-01-01

    I denne artikel anlægges to perspektiver på det æstetiske i et forsøg på at identificere et forhold mellem det æstetiske og det religiøse. Med udgangspunkt i en fænomenologisk karakteristik af den religiøse oplevelse påvises en række lighedspunkter med den æstetiske oplevelse. Desuden defineres d...

  10. Den Blå Drage

    DEFF Research Database (Denmark)

    Ingerslev, Gitte Holten

    Denne publikation i serien Læselyst tjener tre formål. Den evaluerer læseprojektet Den blå drage i efteråret 2004 på Byskolen i Svendborg ? et projekt ledet af forfatteren Josefine Ottesen. Desuden gøres der rede for nogle af de teorier der støtter og begrunder arbejdsmåde og resultater i projektet...

  11. Events i den globale bykonkurrence

    DEFF Research Database (Denmark)

    Østergaard, Katrine

    2005-01-01

    Paper til ph.d. workshop, d. 9. december 2005. Dette paper beskriver, hvorfor og hvordan events kan bruges som strategi for byplanlægning og byudvikling i den globale bykonkurrence.......Paper til ph.d. workshop, d. 9. december 2005. Dette paper beskriver, hvorfor og hvordan events kan bruges som strategi for byplanlægning og byudvikling i den globale bykonkurrence....

  12. Medarbejderdreven innovation i den offentlige sektor

    DEFF Research Database (Denmark)

    Klitmøller, Anders; Lauring, Jakob; Christensen, Poul Rind

    2007-01-01

    Denne artikel har til formål at kaste lys over den rolle, medarbejderne spiller for den innovative aktivitet i den offentlige sektor, hvad vi har valgt at kalde medarbejderdreven innovation. Artiklen er baseret på et etnografisk feltstudie i Århus Kommune, nærmere bestemt den nye afdeling...

  13. Hvad karakteriserer den netbaserede vejledning?

    DEFF Research Database (Denmark)

    Kjeldsen, Lars Peter

    2008-01-01

    Hensigten med artiklen er at bidrage til forståelsen af sider ved den netbaserede vejledning. Fremgangsmåden vil være: •Først at beskrive og diskutere, hvorledes jeg forstår det virtuelle læringsmiljø, herunder en afklaring af, hvad der karakteriserer den netbaserede vejledning. •Dernæst gennem e...... teoretisk afsæt opstille en model for, hvorledes netbaseret vejledning kan bidrage til de studerendes læreproces. • Sidst at give eksempler på hvorledes modellen for netbaseret vejledning kan anvendes i praksis.......Hensigten med artiklen er at bidrage til forståelsen af sider ved den netbaserede vejledning. Fremgangsmåden vil være: •Først at beskrive og diskutere, hvorledes jeg forstår det virtuelle læringsmiljø, herunder en afklaring af, hvad der karakteriserer den netbaserede vejledning. •Dernæst gennem et...

  14. Pierre Janet, Sigmund Freud and Charcot's psychological and psychiatric legacy.

    Science.gov (United States)

    Pérez-Rincón, Héctor

    2011-01-01

    A key moment in the history of psychiatry occurred during Charcot's time at La Salpêtriere. Though his studies on hysteria and hypnotism, the founder of neurology inspired the work of two of his alumni: a Viennese Nervenartz and a French philosopher interested in the dissociation of personality. Even though neither of them was originally an alienist, their respective work allowed the field of neurosis--then belonging to internal medicine--to pass to psychiatry. The parallel lives of these frères enemis, both of whom were treated differently by fame, developed inside a very complex cultural and scientific milieu. Therefore, it is necessary to consider them together with other physicians, some of whom are much less well-known nowadays, who one way or another carried Charcot's influence into psychiatry, psychology and psychotherapy. The fates of the Dioscuri have been reversed--the fame and success of Freudian psychoanalysis ran parallel to Janet's oblivion and his long 'purgatory', but now the 'renaissance' of his work coincides with the decline of psychoanalysis as a theoretical explanation for mental pathology. Copyright © 2011 S. Karger AG, Basel.

  15. Jean-Baptiste Charcot in Rio de Janeiro: glamorous trip and celebrity in 1908

    Directory of Open Access Journals (Sweden)

    Hélio A. G. Teive

    2015-09-01

    Full Text Available The authors review the visit of Commander Charcot and the crew of his ship, the “Pourquoi Pas?”, to Rio de Janeiro, Brazil, in 1908, where he stayed for eight days, while en-route as part of the second French expedition to the Antarctic. It was a glamorous stay as Commander Charcot was treated as a true star and international celebrity, befitting his position.

  16. Charcot joint-like changes following ankle fracture in a patient with no underlying disease: report of a rare case.

    Science.gov (United States)

    Kumagai, Masaru; Yokota, Kiyoshi; Endoh, Toshiya; Takemoto, Hitoshi; Nagata, Kensei

    2002-01-01

    Charcot joint is a disease that often occurs in patients with diabetes mellitus, tabes dorsalis, syringomyelia, chronic alcoholism, leprosy, trauma, or infection after fractures and dislocations. The treatment for Charcot joint has various complications, such as skin lesions, infections, and delayed union. We present our experience with a male patient who developed Charcot joint-like changes without diabetes mellitus or any other disease after an ankle fracture due to minor trauma.

  17. Jean-Martin Charcot's role in the 19th century study of music aphasia.

    Science.gov (United States)

    Johnson, Julene K; Lorch, Marjorie; Nicolas, Serge; Graziano, Amy

    2013-05-01

    Jean-Martin Charcot (1825-93) was a well-known French neurologist. Although he is widely recognized for his discovery of several neurological disorders and his research into aphasia, Charcot's ideas about how the brain processes music are less well known. Charcot discussed the music abilities of several patients in the context of his 'Friday Lessons' on aphasia, which took place at the Salpêtrière Hospital in Paris in 1883-84. In his most comprehensive discussion about music, Charcot described a professional trombone player who developed difficulty copying music notation and playing his instrument, thereby identifying a new isolated syndrome of music agraphia without aphasia. Because the description of this case was published only in Italian by one of his students, Domenico Miliotti, there has been considerable confusion and under-acknowledgement of Charcot's ideas about music and the brain. In this paper, we describe Charcot's ideas regarding music and place them within the historical context of the growing interest in the neurological underpinnings of music abilities that took place in the 1880s.

  18. Hand weakness in Charcot-Marie-Tooth disease 1X.

    LENUS (Irish Health Repository)

    Arthur-Farraj, P J

    2012-07-01

    There have been suggestions from previous studies that patients with Charcot-Marie-Tooth disease (CMT) have weaker dominant hand muscles. Since all studies to date have included a heterogeneous group of CMT patients we decided to analyse hand strength in 43 patients with CMT1X. We recorded handedness and the MRC scores for the first dorsal interosseous and abductor pollicis brevis muscles, median and ulnar nerve compound motor action potentials and conduction velocities in dominant and non-dominant hands. Twenty-two CMT1X patients (51%) had a weaker dominant hand; none had a stronger dominant hand. Mean MRC scores were significantly higher for first dorsal interosseous and abductor pollicis brevis in non-dominant hands compared to dominant hands. Median nerve compound motor action potentials were significantly reduced in dominant compared to non-dominant hands. We conclude that the dominant hand is weaker than the non-dominant hand in patients with CMT1X.

  19. Pressure ulcers and Charcot's definitions: report on two cases

    Directory of Open Access Journals (Sweden)

    Hélio Afonso Ghizoni Teive

    Full Text Available CONTEXT AND OBJECTIVE: Pressure ulcers are lesions caused by inadequate blood flow and tissue malnourishment secondary to prolonged pressure on skin, soft connective tissues, muscle and/or bones. The authors report two distinct clinical situations of severely compromised neurological patients who shared several predisposing factors for pressure ulcers, but with opposite outcomes regarding the development of pressure ulcers. CASE REPORTS: The first case was a young patient in a persistent vegetative state who developed pressure ulcers that resulted in secondary sepsis and death. The second case was a patient with a diagnosis of amyotrophic lateral sclerosis who, in spite of being bedridden for several months with severe immobility, never developed pressure ulcers. These intriguing contrary clinical situations had already been defined by Charcot in the nineteenth century, with his creation of the expression "decubitus ominosus". He indicated that patients with amyotrophic lateral sclerosis usually did not develop this form of complication, as was illustrated by the cases presented here.

  20. den og morderen

    DEFF Research Database (Denmark)

    Hansen, Kim Toft

    2014-01-01

    forskellige versioner af Forbrydelsen: DR's oprindelige udgave, AMC's udgave The Killing og David Hewsons roman Forbrydelsen, der er baseret på manuskriptet til DR-serien. Grundfortællingen under disse tre versioner relaterer jeg til H.C. Andersens "Historien om en Moder" og tilskrivningen af mening til døden....

  1. Tillid i den finansielle sektor

    DEFF Research Database (Denmark)

    Rimmer, Nina Røhr; Nielsen, Sara Møller; Benediktsdottir, Elisabet

    2014-01-01

    , der er i kommunikation med kunden, eksempelvis at videreudvikle på definerede Touch-Points i CEM og opbyggelsen/vedligeholdelsen af kundeoplysninger i CRM systemer således, at den samlede kvalitet af ydelsen bliver så personlig som mulig, hvilket falder godt i tråd med Spar Nords værdigrundlag om dels...

  2. Berlusconi og den moderne fyrste

    DEFF Research Database (Denmark)

    Sørensen, Gert

    voksende forbrugermentalitets gennembrud. Tredje del sætter ind over for Berlusconis frontale angreb på de demokratiske principper og samler op omkring Italiens dybe krise. Den gennemgående analytiske figur er hentet fra Machiavellis Fyrsten om magtens mål og med. Dele af bogen er blevet til i samarbejde...

  3. Publikum svinger den retoriske taktstok

    DEFF Research Database (Denmark)

    Hansen, Jette Barnholdt

    2012-01-01

    Artiklen handler om revyvisen "Man binder os på mund og hånd" af Poul Henningensen med musik af Kai Normann Andersen, som oprindeligt var en del af den kulturradikale revykomedie Dyveke fra 1940, der bla. advokerede for seksuel frigørelse. Visen levede dog hurtigt sit eget liv uden for revyteatret...

  4. Internal Versus External Fixation of Charcot Midfoot Deformity Realignment.

    Science.gov (United States)

    Lee, Daniel J; Schaffer, Joseph; Chen, Tien; Oh, Irvin

    2016-07-01

    Internal and external fixation techniques have been described for realignment and arthrodesis of Charcot midfoot deformity. There currently is no consensus on the optimal method of surgical reconstruction. This systematic review compared the clinical results of surgical realignment with internal and external fixation, specifically in regard to return to functional ambulation, ulcer occurrence, nonunion, extremity amputation, unplanned further surgery, deep infection, wound healing problems, peri- or intraoperative fractures, and total cases with any complication. A search of multiple databases for all relevant articles published from January 1, 1990, to March 22, 2014, was performed. A logistic regression model evaluated each of the outcomes and its association with the type of fixation method. The odds of returning to functional ambulation were 25% higher for internal fixation (odds ratio [OR], 1.259). Internal fixation had a 42% reduced rate of ulcer occurrence (OR, 0.578). External fixation was 8 times more likely to develop radiographic nonunion than internal fixation (OR, 8.2). Internal fixation resulted in a 1.5-fold increase in extremity amputation (OR, 1.488), a 2-fold increase in deep infection (OR, 2.068), a 3.4-fold increase in wound healing complications (OR, 3.405), and a 1.5-fold increase in the total number of cases experiencing any complication (OR, 1.525). This was associated with a 20% increase in the need for unplanned further surgery with internal fixation (OR, 1.221). Although internal fixation may decrease the risk of nonunion and increase return to functional ambulation, it had a higher rate of overall complications than external fixation for realignment and arthrodesis of Charcot midfoot deformity. [Orthopedics. 2016; 39(4):e595-e601.]. Copyright 2016, SLACK Incorporated.

  5. Den svage tænkning

    DEFF Research Database (Denmark)

    Dehs, Jørgen

    1994-01-01

    Interview med Gianni Vattimos. Italiensk politisk kultur, forholdet mellem politikeren og den intelektuelle og Gianni Vattimos program.......Interview med Gianni Vattimos. Italiensk politisk kultur, forholdet mellem politikeren og den intelektuelle og Gianni Vattimos program....

  6. den på glas

    DEFF Research Database (Denmark)

    Meyer, Ion

    2008-01-01

    Artiklen beskriver den eneste danske samling af præparerede fostre og børn, og hvorfor den blev fremstillet. Den var en del af Museum Saxtorphianum og artiklen diskuterer hvordan disse fostre blev til præparater. Musealiseringen, overgangen fra medicinske studieobjekter til museumsgenstande med s...

  7. Den sociale stofmisbrugsbehandling. Del 1

    DEFF Research Database (Denmark)

    Heltberg, Therese

    Denne rapport er den første delrapport i en undersøgelse af den sociale stofmisbrugsbehandling i Danmark, som SFI har gennemført for Servicestyrelsen i perioden december 2007 til maj 2009. Undersøgelsen omhandler den sociale stofmisbrugsbehandling efter § 101 i Serviceloven, mens undersøgelsen i ...

  8. Da den moderne jazz kom til Danmark

    DEFF Research Database (Denmark)

    Høyer, Ole Izard; Nielsen, Anders H.U.

    som tog over, deriblandt Erik Moseholm, Bent Axen og Jørn Elniff. Denne bog forklarer, hvordan den moderne jazz kom til Danmark, og hvordan den udviklede det danske jazzmiljø. Den inddrager faktorer som udenlandske musikeres besøg, koncerter og efterfølgende jazzsessions. Hvilken betydning havde disse...... for den danske jazzudvikling? Hvor blev musikken spillet, og hvordan blev den behandlet af medierne og af samfundet? Sammen med beskrivelser af de vigtigste moderne jazzmusikere fra perioden, analyseres og beskrives en række indspilninger af moderne dansk jazz for at undersøge hvornår, og hvilke af de nye...

  9. Den kulturelle dimension af virksomhedens internationalisering

    DEFF Research Database (Denmark)

    Langhoff, Tine

    1994-01-01

    Artiklen omhandler den kulturelle dimensions indvirkning på virksomhedens internationalisering og diskuterer mulige internationalisieringsstrategier for virksomheder, der konfronteres med kulturforskelle. Med udgangspunkt i en kritik af den hidtidige forskning på området, hvor det såkaldte psykiske...... distancebegreb har haft en central placering, foreslås det, at man som alternativ til dette begreb skal fokusere på virksomhedens markedsbaserede innovationsevne. Denne betegnes som dens interkultu kompetence og vedrører dens evne til at identificere og udnytte muligheder i fremmede kulturelle sammenhænge. Det...... er herved, at den kulturelle dimension påvirker virksomheden og dens fortsatte udvikling. En empirisk analyse i den danske fødevarebranche afdækker virksomheders interkulturelle kompetence ved hjælp af to spørgsmål: (1) Hvorledes formår virksomheder med begrænsede ressourcer til deres disposition...

  10. Den onde eller det onde?

    DEFF Research Database (Denmark)

    Nielsen, Kirsten

    2008-01-01

    Artiklen handler om brugen af billeder for den onde (djævelen) og det onde i moderne salmer. Der er en klar tendens til at foretrække et naturbillede som mørket frem for personbilleder. Mørket kan som billede bruges forholdsvis nuanceret og vil i mange tilfælde ikke forudsætte et dybere kendskab ...

  11. Konsulenten i den anden nat

    DEFF Research Database (Denmark)

    Kirkegaard, Line

    for i sit deres liv og den eksistensmåde, der hermed muliggøres. Med dette ønsker jeg at bidrage til de eksisterende work-life balance teorier. Min vej ind i teorierne er nemlig, at logikken i mit empiriske materiale forekommer så forskelligt fra de traditionelle work-life balance teorier, at disse ikke...... lader sig forene. Jeg foretage derfor en analyse af den eksisterende litteratur, og rejser i den forbindelse en grundlæggende kritik af work-life balance teorierne, for at operere med falske problemstillinger på en måde, så svaret allerede indgår i de spørgsmål, der stilles. Jeg argumenterer således for......, at det problematiske forhold ved work-life balance teorierne allerede skal søges i konstitueringen af deres problematik, hvor arbejde og fritid indgår som to distinkte og kontrasterende sfærer. Ubalance eller problemer søges således altid i relationen her imellem. I forlængelse heraf argumenterer jeg for...

  12. Pressure pain perception in the diabetic Charcot foot: facts and hypotheses

    Directory of Open Access Journals (Sweden)

    Ernst A. Chantelau

    2013-05-01

    Full Text Available Background:Reduced traumatic and posttraumatic (nociceptive pain is a key feature of diabetic neuropathy. Underlying condition is a gradual degeneration of endings of pain nerves (A-delta fibers and C-fibers, which operate as receivers of noxious stimuli (nociceptors. Hence, the absence of A-delta fiber mediated sharp pain (“first” pain, and of C-fiber mediated dull pain (“second” pain. However, patients with diabetic neuropathy and acute Charcot foot often experience deep dull aching in the Charcot foot while walking on it. Aim: To create a unifying hypothesis on the kind of pain in an acute Charcot foot. Result: Absence of punctuate (pinprick pain perception at the sole of a Charcot foot, as was shown recently, likely corresponds to vanished intraepidermal A-delta fiber endings. C-fiber nociceptors are reduced, according to histopathology studies. Both types of fibers contribute to posttraumatic hyperalgesia at the skin level, as studies show. Their deficiencies likely impact on posttraumatic hyperalgesia at the skin level and, probably, also at the skeletal level. Conclusion: It is hypothesised that deep dull aching in an acute diabetic Charcot foot may represent faulty posttraumatic hyperalgesia involving cutaneous and skeletal tissues.

  13. Édouard Brissaud, Fulgence Raymond and the succession of Charcot.

    Science.gov (United States)

    Tatu, Laurent

    2011-01-01

    At the time of his death in 1893, Jean-Martin Charcot (1825-1893) had reigned supreme over neurology in Paris for some 10 years. The problem of finding a successor was not easy to solve, and it was initially agreed that a temporary replacement should be found. Édouard Brissaud (1852-1909), one of Charcot's students and close associates, was charged with this mission. With the support of some of Charcot's other former students, he held the position of chair for diseases of the nervous system for 1 year. In theory, there were a number of potential successors, but only three were officially declared: Édouard Brissaud, Jules Déjerine (1849-1917) and Fulgence Raymond (1844- 1910). Other students of Charcot such as Pierre Marie (1853-1940), Alix Joffroy (1844-1908), Joseph Babinski (1857-1932) and Georges Gilles de la Tourette (1857-1904) had to withdraw their candidature for various reasons. The election culminated in the appointment of Fulgence Raymond as Charcot's successor. Although such an impossible succession was beyond Raymond, his work in neurology, which is often unrecognised, made him one of the most important neurologists of the early 20th century. Copyright © 2011 S. Karger AG, Basel.

  14. The effectiveness of non-surgical interventions in the treatment of Charcot foot.

    Science.gov (United States)

    Smith, Caroline; Kumar, Saravana; Causby, Ryan

    2007-12-01

    Background  Charcot neuropathic osteoarthropathy is commonly known as 'Charcot foot'. It is a serious foot complication of diabetes mellitus that can frequently lead to foot ulceration, gangrene, hospital admission and foot amputation. A multidisciplinary approach to the management of Charcot foot is taken involving medical and allied health professionals. The management approach may also differ between different countries. To date, there is no systematic review of the literature undertaken to identify the clinical effectiveness of non-operative interventions in the treatment of acute Charcot foot. Objective  The objective of this review was to identify the effectiveness of non-surgical interventions with reducing lesions, ulceration, the rate of surgical intervention, reducing hospital admissions and improve the quality of life of subjects with Charcot foot. Search strategy  A comprehensive search strategy was undertaken on databases available from University of South Australia from their inception to November 2006. Selection criteria  Randomised controlled trials or clinical controlled trials were primarily sought. Critical appraisal of study quality and data extraction was undertaken using Joanna Briggs Institute instruments. Review Manager software was used to calculate comparative statistics. Results  This review identified 11 trials and five trials were included in the review. Three trials involved the use of bisphosphonate, a pharmacological agent. Two experimental treatments were also included, evaluating palliative radiology and magnetic fields. No trials were found using immobilisation and off-loading interventions for acute Charcot foot. The overall methodological quality score of the five studies was moderate. Owing to heterogeneous data, meta-analysis could not be performed. The trials did not report on reducing lesions, ulceration, rate of surgical intervention, hospital admissions and the quality of life of subjects with Charcot foot. The

  15. Sleep disorders in Charcot-Marie-Tooth disease type 1.

    Science.gov (United States)

    Boentert, Matthias; Knop, Katharina; Schuhmacher, Christine; Gess, Burkhard; Okegwo, Angelika; Young, Peter

    2014-03-01

    Obstructive sleep apnoea (OSA) and restless legs syndrome (RLS) have been reported in Charcot-Marie-Tooth disease (CMT) type 1A and axonal subtypes of CMT, respectively. The aim of this case-control study was to investigate both prevalence and severity of OSA, RLS and periodic limb movements in sleep (PLMS) in adult patients with genetically proven CMT1. 61 patients with CMT1 and 61 insomnic control subjects were matched for age, sex, and Body Mass Index. Neurological disability in patients with CMT was assessed using the Functional Disability Scale (FDS). RLS diagnosis was based on a screening questionnaire and structured clinical interviews. All participants underwent overnight polysomnography. OSA was present in 37.7% of patients with CMT1 and 4.9% of controls (psleep quality. In addition to known risk factors, CMT may predispose to OSA. RLS is highly prevalent not only in axonal subtypes of CMT but also in primarily demyelinating subforms of CMT. PLMS are common in CMT1, but do not significantly impair sleep quality.

  16. Reliability of AOFAS diabetic foot questionnaire in Charcot arthropathy: stability, internal consistency, and measurable difference.

    Science.gov (United States)

    Dhawan, Vibhu; Spratt, Kevin F; Pinzur, Michael S; Baumhauer, Judith; Rudicel, Sally; Saltzman, Charles L

    2005-09-01

    The development of Charcot changes is known to be associated with a high rate of recurrent ulceration and amputation. Unfortunately, the effect of Charcot arthropathy on quality of life in diabetic patients has not been systematically studied because of a lack of a disease-specific instrument. The purpose of this study was to develop and test an instrument to evaluate the health-related quality of life of diabetic foot disease. Subjects diagnosed with Charcot arthropathy completed a patient self-administered questionnaire, and clinicians completed an accompanying observational survey. The patient self-administered questionnaire was organized into five general sections: demographics, general health, diabetes-related symptoms, comorbidities, and satisfaction. The scales measured the effect in six health domains: 1) general health, 2) care, 3) worry, 4) sleep, 5) emotion, and 6) physicality. The psychometric properties of the scales were evaluated and the summary scores for the Short-Form Health Survey (SF-36) were compared to published norms for other major medical illnesses. Of the 89 enrolled patients, 57 who completed the questionnaire on enrollment returned a second completed form at 3-month followup. Over the 3-month followup period most of the patients showed an improvement in the Eichenholtz staging. The internal consistency of most was moderate to high and, in general, the scale scores were stable over 3 months. However, several of the scales suffered from low-ceiling or high-floor effects. Patients with Charcot arthropathy had a much lower physical component score on enrollment than the reported norms for other disease conditions, including diabetes. Quality of life represents an important set of outcomes when evaluating the effectiveness of treatment for patients with Charcot arthropathy. This study represents an initial attempt to develop a standardized survey for use with this patient population. Further studies need to be done with larger groups of

  17. Jean-Martin Charcot and art: relationship of the "founder of neurology" with various aspects of art.

    Science.gov (United States)

    Bogousslavsky, Julien; Boller, François

    2013-01-01

    Jean-Martin Charcot (1825-1893), the "father of neurology" in France and much beyond, was also the man who established academic psychiatry in Paris, differentiating it from clinical alienism. In his teaching, he used artistic representations from previous centuries to illustrate the historical developments of hysteria, mainly with the help of his pupil Paul Richer. Charcot liked to draw portraits (in particular, sketches of colleagues during boring faculty meetings and students' examinations), caricatures of himself and others, church sculptures, landscapes, soldiers, etc. He also used this skill in his clinical and scientific work; he drew histological or anatomic specimens, as well as patients' features and demeanor. His most daring artistic experiments were drawing under the influence of hashish. Charcot's tastes in art were conservative; he displayed no affinity for the avant-gardes of his time, including impressionism, or for contemporary musicians, such as César Franck or Hector Berlioz. Léon Daudet, son of Charcot's former friend and famous writer Alphonse Daudet, described Charcot's home as a pseudo-gothic kitsch accumulation of heteroclite pieces of furniture and materials. However, as Henry Meige wrote a few years after his mentor's death, Charcot the artist remains "inseparable from Charcot the physician." © 2013 Elsevier B.V. All rights reserved.

  18. Die grossen Physiker und ihre Entdeckungen von den fallenden Körpern zu den Quarks

    CERN Document Server

    Segrè, Emilio

    1998-01-01

    Von Galileo Galilei bis zu Richard Feynman und Murray Gell-Mann - von den fallenden Körpern zu den Quarks: Der Physiknobelpreisträger Emilio Segre hat seine ganz persönliche Geschichte der Physik geschrieben. Er erzählt von den großen Gestalten und deren wichtigen Entdeckungen mit großer Anschaulichkeit und Lebendigkeit.

  19. Forever Young - den norske tv-serie Skam

    DEFF Research Database (Denmark)

    Jerslev, Anne

    2016-01-01

    Hvorfor er det lige, at den norske netbaserede ungdomsserie "Skam" er på alles læber for tiden? Svaret er simpelt: Den er nyskabende og supergod, og den taler til en langt bredere målgruppe end den gruppe af teenagepiger, den er rettet mod....

  20. Cornelis den Hartog: an outstanding aquatic ecologist

    NARCIS (Netherlands)

    Velde, van der G.; Brock, T.C.M.; Kempers, A.J.

    1996-01-01

    A survey is given of the work and life of Cornelis den Hartog up to the date in 1996 on which he retired from his position as a professor at the University of Nijmegen. Cornelis (Kees) den Hartog made important contributions to aquatic ecology in the widest sense, e.G. On brackish water typology,

  1. Nyliberalisme, universiteter og den akademiske frihed

    DEFF Research Database (Denmark)

    Madsen, Mogens Ove

    2012-01-01

    Akademisk frihed er uløseligt forbundet med det, der er selve universitetets væsen. New Public Management er dog sevet ind i den offentlige forvaltning og kapitlet giver et signalement af, hvilke konsekvenser dette har haft for universiteterne og den akademiske frihed...

  2. koncernbegrebet og tilbudspligtens indtræden

    DEFF Research Database (Denmark)

    Clausen, Nis Jul; sørensen, karsten engsig

    2010-01-01

      Med den nye selskabslov og de hertil knyttede ændringer i værdipapirhandelslovens regler om tilbudspligt har man fastholdt ønsket om parallelitet mellem det selskabsretlige koncernbegreb og kriterierne for tilbudspligtens indtræden. Det drøftes, om koncernbegrebet reelt er overført til tilbudsp...

  3. Den tabte fortælling

    DEFF Research Database (Denmark)

    Jørgensen, Kenneth Mølbjerg

    2008-01-01

    Ledelse er et af nøgleordene i fornyelsen af den offentlige sektor. Vi har imidlertid glemt et væsentligt aspekt af ledelse. Dette skyldes ikke mindst, at omgangsformen i dag er reguleret af information, mens den tidligere var reguleret af fortælleevnen. Evnen til dialog, indlevelse og nærvær er...

  4. Luftstaub über den Meeren

    DEFF Research Database (Denmark)

    Kacunko, Slavko; Kacunko, Sabine; Gorbushina, Ana

    2013-01-01

    Staub umgibt uns überall und alles wird auch irgendwann zu Staub - ob wir wollen oder nicht. Staub nicht nur zu bekämpfen, sondern zu untersuchen, bildet den Ausgangspunkt zahlreicher Forschungen in den Natur-, Ingenieur- und Kulturwissenschaften. Der vorliegende Band verbindet solche Beiträge au...

  5. Jean-Martin Charcot and Parkinson's disease: Teaching and teaching materials.

    Science.gov (United States)

    Walusinski, O

    2018-04-10

    James Parkinson's 1817 seminal article was not well known in France until 1861, when Jean-Martin Charcot and his friend, Alfred Vulpian, published a detailed description in French of paralysis agitans. Their article provided clinical information to help French physicians make an accurate diagnosis by considering gait, shaking and rigidity as well as masked facies. As Charcot always had a strong desire to teach, this article describes his lessons on Parkinson's disease from 1868 to 1888, and also examines the teaching approach he used to pass on his latest findings to his students and colleagues. Charcot also used his role as thesis advisor to disseminate Parkinson's work, and seven of the theses he oversaw, which until now have been overlooked, reveal another facet of his teacher-student relationship. These dissertations provided Charcot with an opportunity to highlight what he had already identified concerning what is today referred to as 'Parkinson-plus syndromes'. Finally, this report concludes with an historical survey of the teaching materials that Paul Richer and Albert Londe developed for the Master at La Salpêtrière to provide him with visual documentation. Copyright © 2018 Elsevier Masson SAS. All rights reserved.

  6. Hip Subluxation, first clinical manifestation in a boy with illness of Charcot Marie Tooth

    International Nuclear Information System (INIS)

    Marin Nino, Jorge Enrique; Rosselli Cock, Pablo

    2005-01-01

    Charcot-Marie-Tooth disease is a motor and sensitive neuropathy characterized by limb atrophy and weakness, cavus feet and in some cases acetabular dysplasia. We present a case of bilateral hip subluxation caused by this disease, which needed surgical correction

  7. Dysfunction in the hip joints in children with Charcot-Marie-Tooth syndrome (literature review

    Directory of Open Access Journals (Sweden)

    Ivan Yurievich Pozdnikin

    2015-09-01

    Full Text Available A review of the literature on the treatment of children with dysfunction in the hip joints in motor-sensory neuropathy Charcot-Marie-Tooth is presented. Peculiarities of disease diagnosis and the approach used in the treatment of patients are described. The Charcot-Marie-Tooth syndrome is a hereditary neuromuscular disease characterized by progressive atrophy of the distal muscle group of the lower limbs. According to international authors, the incidence of hip joint dysfunction in this condition is at least 10%, ranking second only to foot deformities. In the Russian literature, the problem has not been adequately interpreted. Early diagnosis of dysfunction in the hip joints during Charcot-Marie-Tooth syndrome is complicated by the child's age and is characterized by progression. Conflicting clinical signs and trivial symptoms of the disease also confuse diagnosis, until it becomes clearer in adolescence or the second or third decade of life. Surgical reconstructive operations on the hip joint often occur too late, and they are accompanied by a greater frequency of neurological complications. Practitioner awareness coupled with an early diagnosis of hip subluxation and decentration and complex orthopedic and neurological examinations of children with the disease of Charcot-Marie-Tooth should result in more favorable outcomes.

  8. Hand involvement in children with Charcot-Marie-Tooth disease type 1A

    NARCIS (Netherlands)

    Burns, Joshua; Bray, Paula; Cross, Lauren A.; North, Kathryn N.; Ryan, Monique M.; Ouvrier, Robert A.

    2008-01-01

    Charcot-Marie-Tooth disease type 1A (CMT1A), a demyelinating neuropathy characterised by progressive length-dependent muscle weakness and atrophy, is thought to affect the foot and leg first followed some time later by hand weakness and dysfunction. We aimed to characterise hand Strength, function

  9. Charcot-Marie-Tooth disease: frequency of genetic subtypes and guidelines for genetic testing.

    LENUS (Irish Health Repository)

    Murphy, Sinead M

    2012-07-01

    Charcot-Marie-Tooth disease (CMT) is a clinically and genetically heterogeneous group of diseases with approximately 45 different causative genes described. The aims of this study were to determine the frequency of different genes in a large cohort of patients with CMT and devise guidelines for genetic testing in practice.

  10. Effective cauda equina decompression in two siblings with Charcot-Marie-Tooth disease type 1B

    NARCIS (Netherlands)

    van Doormaal, Tristan P C; van Ruissen, Fred; Miller, Kai J; Hoogendijk, Jessica E

    2016-01-01

    Two siblings with Charcot-Marie-Tooth (CMT) 1B due to a c.517G>C (p.Gly173Arg) mutation in the MPZ gene both developed an acute cauda syndrome with unbearable back pain radiating to both legs, progressive muscle weakness of the legs, and saddle hypesthesia with fecal and urinary incontinence. MRI

  11. Data Mining for Identifying Novel Associations and Temporal Relationships with Charcot Foot

    Directory of Open Access Journals (Sweden)

    Michael E. Munson

    2014-01-01

    Full Text Available Introduction. Charcot foot is a rare and devastating complication of diabetes. While some risk factors are known, debate continues regarding etiology. Elucidating other associated disorders and their temporal occurrence could lead to a better understanding of its pathogenesis. We applied a large data mining approach to Charcot foot for elucidating novel associations. Methods. We conducted an association analysis using ICD-9 diagnosis codes for every patient in our health system (n=1.6 million with 41.2 million time-stamped ICD-9 codes. For the current analysis, we focused on the 388 patients with Charcot foot (ICD-9 713.5. Results. We found 710 associations, 676 (95.2% of which had a P value for the association less than 1.0×10−5 and 603 (84.9% of which had an odds ratio > 5.0. There were 111 (15.6% associations with a significant temporal relationship P<1.0×10−3. The three novel associations with the strongest temporal component were cardiac dysrhythmia, pulmonary eosinophilia, and volume depletion disorder. Conclusion. We identified novel associations with Charcot foot in the context of pathogenesis models that include neurotrophic, neurovascular, and microtraumatic factors mediated through inflammatory cytokines. Future work should focus on confirmatory analyses. These novel areas of investigation could lead to prevention or earlier diagnosis.

  12. Genfortryllelse i den digitale tidsalder

    DEFF Research Database (Denmark)

    Madsen, Theis Vallø

    , hvilket bl.a. kommer til udtryk i en ny vinylplade- og polaroidbillede-interesse. Denne undersøgelse går tilbage til begyndelsen af oplysningstiden, op igennem det 20. århundrede og frem til vores digitale kultur for at beskrive baggrunden og forestillingerne bag denne form for “analog æstetik”.......I den digitale tidsalder bliver uhyre mængder af information, billeder og musik noget nær frit tilgængelige, uendeligt reproducérbare og frigjort fra sit ”her” og ”nu”. I samme stund er der opstået en fornyet interesse for artefakter, der er stoflige, håndgribelige og u- eller anti-digitale...

  13. Denning of grizzly bears in the Yellowstone National Park area

    Science.gov (United States)

    Judd, Steven L.; Knight, Richard R.; Blanchard, Bonnie M.

    1986-01-01

    Radiotelemetry was used to locate 101 grizzly bear (Ursus arctos) dens from 1975 to 1980; 35 dens were examined on the ground. Pregnant females denned in late October, and most other bears denned by mid-November. Duration of denning average 113, 132, and 170 days for males, females, and females with new cubs, respectively. Males emerged from mid-February to late March, followed by single females and females with yearlings and 2-year-olds. Females with new cubs emerged from early mid-April. Den sites were associated with moderate tree cover (26%-75% canopy cover) on 30°-60° slopes. Dens occurred on all aspects, although northerly exposures were most common. Grizzly bears usually dug new dens but occasionally used natural cavities or a den from a previous year. Males usually dug larger dens than females with young. Eight excavated and 2 natural dens of the 35 examined dens were used for more than 1 year.

  14. Den moderne tyske roman 1909-35

    DEFF Research Database (Denmark)

    Ved siden af klassikken og romantikken er den tidlige modernisme vel nok den betydeligste periode i tysksproget litteratur. Det skyldes ikke mindst den perlerække af romaner, der udkom i første tredjedel af det 20. århundrede, og hvoraf mange i dag fremstår som indiskutable højdepunkter i såvel...... tysk som europæisk roman- og litteraturhistorie. I Den moderne tyske roman 1909-35 behandles en række af disse romaner for første gang samlet på dansk. Bogen består af otte romanfortolkninger samt en indledende artikel om den moderne romans historie og særpræg. Alle artikler er skrevet med et solidt...... interesserede læser. I overensstemmelse med dens formidlende sigte er der kun medtaget fortolkninger af romaner, der foreligger på dansk i en tidssvarende oversættelse. Af hensyn til den litteraturhistoriske bredde er der desuden kun medtaget én roman af samme forfatter.Bogen indeholder analyser af: Robert...

  15. Angiographic assessment of atherosclerotic load at the lower extremity in patients with diabetic foot and charcot neuro-arthropathy.

    Science.gov (United States)

    Çildağ, Mehmet B; Ertuğrul, Bülent M; Köseoğlu, Ömer Fk; Çildağ, Songül; Armstrong, David G

    2018-06-01

    The aim of this study was to investigate atherosclerotic load at the lower extremity in patients with diabetic foot and charcot neuro-arthropathy and compare them with patients with diabetic foot without charcot neuro-arthropathy. This retrospective study consists of 78 patients with diabetic foot who had lower extremity angiography with antegrade approach. All patients were classified into two groups; neuro ischemic wounds with charcot neuro-arthropathy (30/78) and without charcot neuro-arthropathy (48/78).Atherosclerotic load at the side of diabetic foot was determined by using the Bollinger angiogram scoring method. Comparison of atherosclerotic load between the two groups was performed. The mean of total and infrapopliteal level angiogram scoring of all patients was 33.3 (standard deviation, sd:±17.2) and 29.3 (sd:±15.6), respectively. The mean of total and infrapopliteal level angiogram scoring of neuroischemic wounds with charcot neuro-arthropathy group was 18.1 (sd:±11.6) and 15.7 (sd:±10.4), respectively. The mean of total and infrapopliteal level angiogram scoring of neuroischemic wounds without charcot neuro-arthropathy group was 42.8 (sd:±12.7) and 37.7 (sd:±12.0), respectively. There was a statistically significant difference between the two groups of mean total and infrapopliteal angiogram scoring (p diabetic foot and chronic charcot neuro-arthropathy is significantly less than in patients with neuroischemic diabetic foot wounds without chronic charcot neuro-arthropathy. Copyright © 2017. Published by Elsevier Taiwan LLC.

  16. Transnational organisatorisk innovation i den offentlige sektor

    DEFF Research Database (Denmark)

    Hansen, Morten Balle

    2013-01-01

    Artiklen undersøger tre problemstillinger: 1) Hvor udbredt er forskellige former for transnational organisatorisk innovation i den danske offentlige sektor? 2) Hvordan er disse organisatoriske innovationer relateret til hinanden? 3) Er forskelle i deres udbredelse relateret til forskelle mellem den...... forskelle og ligheder mellem statslige og kommunale organisationer. 11 former for organisatorisk innovation, hvoraf mange ofte forbindes med New Public Management (NPM), er inkluderet i de empiriske analyser: privatisering/udlicitering, Bestiller-Udfører-model, kontraktstyring, mål- og rammestyring...... innovationer. Forskellige fortolkninger af den større udbredelse i kommuner end i stat drøftes....

  17. ALS5/SPG11/KIAA1840 mutations cause autosomal recessive axonal Charcot-Marie-Tooth disease.

    Science.gov (United States)

    Montecchiani, Celeste; Pedace, Lucia; Lo Giudice, Temistocle; Casella, Antonella; Mearini, Marzia; Gaudiello, Fabrizio; Pedroso, José L; Terracciano, Chiara; Caltagirone, Carlo; Massa, Roberto; St George-Hyslop, Peter H; Barsottini, Orlando G P; Kawarai, Toshitaka; Orlacchio, Antonio

    2016-01-01

    Charcot-Marie-Tooth disease is a group of hereditary peripheral neuropathies that share clinical characteristics of progressive distal muscle weakness and atrophy, foot deformities, distal sensory loss, as well as diminished tendon reflexes. Hundreds of causative DNA changes have been found, but much of the genetic basis of the disease is still unexplained. Mutations in the ALS5/SPG11/KIAA1840 gene are a frequent cause of autosomal recessive hereditary spastic paraplegia with thin corpus callosum and peripheral axonal neuropathy, and account for ∼ 40% of autosomal recessive juvenile amyotrophic lateral sclerosis. The overlap of axonal Charcot-Marie-Tooth disease with both diseases, as well as the common autosomal recessive inheritance pattern of thin corpus callosum and axonal Charcot-Marie-Tooth disease in three related patients, prompted us to analyse the ALS5/SPG11/KIAA1840 gene in affected individuals with autosomal recessive axonal Charcot-Marie-Tooth disease. We investigated 28 unrelated families with autosomal recessive axonal Charcot-Marie-Tooth disease defined by clinical, electrophysiological, as well as pathological evaluation. Besides, we screened for all the known genes related to axonal autosomal recessive Charcot-Marie-Tooth disease (CMT2A2/HMSN2A2/MFN2, CMT2B1/LMNA, CMT2B2/MED25, CMT2B5/NEFL, ARCMT2F/dHMN2B/HSPB1, CMT2K/GDAP1, CMT2P/LRSAM1, CMT2R/TRIM2, CMT2S/IGHMBP2, CMT2T/HSJ1, CMTRID/COX6A1, ARAN-NM/HINT and GAN/GAN), for the genes related to autosomal recessive hereditary spastic paraplegia with thin corpus callosum and axonal peripheral neuropathy (SPG7/PGN, SPG15/ZFYVE26, SPG21/ACP33, SPG35/FA2H, SPG46/GBA2, SPG55/C12orf65 and SPG56/CYP2U1), as well as for the causative gene of peripheral neuropathy with or without agenesis of the corpus callosum (SLC12A6). Mitochondrial disorders related to Charcot-Marie-Tooth disease type 2 were also excluded by sequencing POLG and TYMP genes. An additional locus for autosomal recessive Charcot

  18. Bone mineral density and markers of bone turnover and inflammation in diabetes patients with or without a Charcot foot

    DEFF Research Database (Denmark)

    Jansen, Rasmus Bo; Christensen, Tomas Møller; Bülow, Jens

    2018-01-01

    BACKGROUND AND AIMS: Charcot foot is a rare but severe complication to diabetes and peripheral neuropathy. It is still unclear if an acute Charcot foot has long-term effects on the bone metabolism. To investigate this, we conducted a follow-up study to examine if a previously acute Charcot foot has...... any long-term effects on bone mineral density (BMD) or local or systemic bone metabolism. METHODS: An 8.5-year follow-up case-control study of 44 individuals with diabetes mellitus, 24 of whom also had acute or chronic Charcot foot at the baseline visit in 2005-2007, who were followed up in 2015......RANK-L/OPG ratio also significantly decreased from baseline to follow-up in the Charcot group (3.4 versus 0.5) (p = 0.009), but not in the control group (1.3 versus 1.1) (p = 0.302). CONCLUSION: We found that diabetes patients with an acute Charcot foot have an elevated fsRANK-L/OPG ratio, and that the level...

  19. van den Heuvel, Prof. Edward P J

    Indian Academy of Sciences (India)

    van den Heuvel, Prof. Edward P J . Date of birth: 2 November 1940. Address: Professor of Astrophysics, Astronomical Inst. Anton Pannekoek, Postbus 94249, 1090 GE Amsterdam, The Netherlands Contact: Office: (+31-20) 525 ...

  20. A Factor Increasing Venous Contamination on Bolus Chase Three-dimensional Magnetic Resonance Imaging: Charcot Neuroarthropathy.

    Science.gov (United States)

    Çildağ, Mehmet B; Ertuğrul, Mustafa B; Köseoğlu, Ömer Fk; Armstrong, David G

    2018-01-01

    The study aimed to evaluate the ratio of venous contamination in diabetic cases without foot lesion, with foot lesion and with Charcot neuroarthropathy (CN). Bolus-chase three-dimensional magnetic resonance (MR) of 396 extremities of patients with diabetes mellitus was analyzed, retrospectively. Extremities were divided into three groups as follows: diabetic patients without foot ulcer or Charcot arthropathy (Group A), patients with diabetic foot ulcers (Group B) and patients with CN accompanying diabetic foot ulcers (Group C). Furthermore, amount of venous contamination classified as no venous contamination, mild venous contamination, and severe venous contamination. The relationship between venous contamination and extremity groups was investigated. Severe venous contamination was seen in Group A, Group B, and Group C, 5.6%, 15.2%, and 34.1%, respectively. Statistically significant difference was seen between groups with regard to venous contamination. Venous contamination following bolus chase MR was higher in patients with CN.

  1. Current Approaches to Diagnosis and Classification Features of Neuroosteoarthropathy Charcot (literature review

    Directory of Open Access Journals (Sweden)

    Balatiuk Irina

    2016-12-01

    Full Text Available The article provides the analysis of the publications of domestic and foreign authors on such complication of diabetes as diabetic Charcot osteoarthropathy. It formulates modern domestic classification of diabetic foot syndrome. It has been stated that diabetic foot syndrome is a serious medical and social problem, due to the high level of disability of patients, it causes significant social and economic losses to society. Pathogenetic basis for the development of diabetic osteoarthropathy is a combination of uncontrolled bone resorption and the lack of sensitivity of the defense, which leads to the destruction of joints. The gold standard for diagnosis of Charcot osteoarthropathy is X-ray densitometry that allows you to objectively assess the state of bone mineral density.

  2. A factor increasing venous contamination on bolus chase three-dimensional magnetic resonance imaging: Charcot neuroarthropathy

    Directory of Open Access Journals (Sweden)

    Mehmet B Cildag

    2018-01-01

    Full Text Available Background: The study aimed to evaluate the ratio of venous contamination in diabetic cases without foot lesion, with foot lesion and with Charcot neuroarthropathy (CN. Materials and Methods: Bolus-chase three-dimensional magnetic resonance (MR of 396 extremities of patients with diabetes mellitus was analyzed, retrospectively. Extremities were divided into three groups as follows: diabetic patients without foot ulcer or Charcot arthropathy (Group A, patients with diabetic foot ulcers (Group B and patients with CN accompanying diabetic foot ulcers (Group C. Furthermore, amount of venous contamination classified as no venous contamination, mild venous contamination, and severe venous contamination. The relationship between venous contamination and extremity groups was investigated. Results: Severe venous contamination was seen in Group A, Group B, and Group C, 5.6%, 15.2%, and 34.1%, respectively. Statistically significant difference was seen between groups with regard to venous contamination. Conclusion: Venous contamination following bolus chase MR was higher in patients with CN.

  3. Overlapping molecular pathological themes link Charcot-Marie-Tooth neuropathies and hereditary spastic paraplegias.

    Science.gov (United States)

    Timmerman, Vincent; Clowes, Virginia E; Reid, Evan

    2013-08-01

    In this review we focus on Charcot-Marie-Tooth (CMT) neuropathies and hereditary spastic paraplegias (HSPs). Although these diseases differ in whether they primarily affect the peripheral or central nervous system, both are genetically determined, progressive, long axonopathies that affect motor and sensory pathways. This commonality suggests that there might be similarities in the molecular pathology underlying these conditions, and here we compare the molecular genetics and cellular pathology of the two groups. Copyright © 2012 Elsevier Inc. All rights reserved.

  4. Jean-Martin Charcot, father of modern neurology: an homage 120 years after his death

    OpenAIRE

    Gomes, Marleide da Mota; Engelhardt, Eliasz

    2013-01-01

    Jean-Martin Charcot was a pioneer in a variety of subjects, including nervous system diseases; anatomy; physiology; pathology; and diseases of ageing, joints, and lungs. His medical achievements were mainly based on his anatomopathological proficiency, his observation, and his personal thoroughness that favored the delineation of the nosology of the main neurological diseases, including multiple sclerosis, amyotrophic lateral sclerosis, Parkinson’s disease, peroneal muscular atrophy, and hyst...

  5. Serial casting for reconstruction of a deformed Charcot foot: a case report.

    Science.gov (United States)

    Rosenblum, Jonathan I; Weiss, Shmuel; Gazes, Michael; Amit-Kohn, Michal

    2015-05-01

    Charcot neuroarthropathy may occur in patients with peripheral neuropathy who do not notice pain while their bones and joints collapse or breakdown under the constant pressure of body weight. This can lead to ulcerations from severe deformity and potentially limb-threatening and life-threatening infections. Current treatments vary from immobilization to extensive reconstructive surgical interventions. Serial casting, used to correct many pediatric deformities while bones are often more pliable, was used with a 63-year-old male patient who presented with an active phase of Charcot foot with ulceration. The patient previously underwent foot reconstruction and had all hardware removed prior to serial casting. Due to the potential pliability of the bones, serial casting was attempted to reform the shape and position of the foot in a reverse Ponseti-type serial casting to create a more stable structure with less deformity that could lead to epithelial breakdown. The patient regained full ambulation with a plantargrade foot and no wounds, and was followed without complications for 36 months. Serial weekly casting was an effective modality for treatment of this patient's Charcot foot deformity.

  6. Syringomyelia with Chiari I Malformation Presenting as Hip Charcot Arthropathy: A Case Report and Literature Review

    Directory of Open Access Journals (Sweden)

    Roya Memarpour

    2015-01-01

    Full Text Available Neuroarthropathy (neuropathic osteoarthropathy, also known as Charcot joint, is a condition characterized by a progressive articular surface destruction in the setting of impaired nociceptive and proprioceptive innervation of the involved joint. It is seen most commonly in the foot and ankle secondary to peripheral neuropathy associated with diabetes mellitus. Cases of hip (Charcot neuroarthropathy are rare and almost exclusively reported in patients with neurosyphilis (tabes dorsalis. We report a case of a 36-year-old man who presented to the emergency department complaining of right hip pain. On physical examination, pain and thermal sensory deficits were noted in the upper torso with a cape-like distribution, as well as signs of an upper motor neuron lesion in the left upper and lower extremities. A magnetic resonance imaging study (MRI of the right hip showed evidence of early articular surface destruction and periarticular edema consistent with hip Charcot arthropathy. An MRI of the spine revealed an Arnold-Chiari type I malformation with extensive syringohydromyelia of the cervical and thoracic spine.

  7. Charcot arthropathy of the lumbar spine treated using one-staged posterior three-column shortening and fusion.

    Science.gov (United States)

    David, Kenny Samuel; Agarwala, Amit Omprakash; Rampersaud, Yoga Raja

    2010-06-15

    Case report. We present a case of lumbar Charcot arthropathy successfully treated surgically using posterior 3-column resection, spinal shortening, and fusion. The operative treatment of Charcot arthropathy of the spine has conventionally been a combination of anterior and posterior surgery. The morbidity associated with these surgical procedures can be considerable. A posterior-only approach to the problem would avoid the additional morbidity associated with an anterior approach. We present a case of lumbar Charcot arthropathy with deformity treated successfully using such a procedure. Discussion of the patient's clinical and radiologic history, the technical merits of the operative intervention and a review of the relevant background literature are presented. A multilevel, single-stage, posterior 3-column resection with primary shortening and instrumented fusion augmented with rhBMP2 in a multiply operated patient with deformity provided a optimal biologic and mechanical environment for healing of the Charcot arthropathy and improved the sagittal and coronal profile of the spine. A single-stage, multilevel, posterior 3-column resection and primary shortening can be a useful surgical strategy in symptomatic patients with Charcot arthropathy of the spine.

  8. Polar bear maternity denning in the Beaufort Sea

    Science.gov (United States)

    Amstrup, Steven C.; Gardner, Craig L.

    1994-01-01

    The distribution of polar bears (Ursus maritimus) is circumpolar in the NOrthern Hemisphere, but known locations of maternal dens are concentrated in relatively few, widely scattered locations. Denning is either uncommon or unknown within gaps. To understand effects of industrial development and propose increases in hunting, the temporal and spatial distribution of denning in the Beaufort Sea must be known. We caputred and radiocollared polar bears between 1981 and 1991 and determined tht denning in the Beaufort Sea region was sufficient to account for the estimated population there. Of 90 dend, 48 were on drifting pack ice, 38 on land, and 4 on land-fast ice. The portions of dens on land was higher (P= 0.029) in later compared with earlier years of the study. Bears denning on pack ice drifting as far as 997 km (x=385km) while in dens. there was no difference in cun production by bears denning on land and pack ice (P =0.66). Mean entry and exit dates were 11 November and 5 April for land dens and 22 November and 26 March for pack-ice dens. Female polar bears captured in the Beaufort Sea appeared to be isolated from those caught eat of Cape Bathurst in Canada. Of 35 polar bears that denned along the mainland coast of Alaska and Canada 80% denned between 137 00'W snf 146 59'W. Bears followed to >1 den did not reuse sites and consecutive dens were 20-1,304 km apart. However radio-collared bears are largely faithful to substrate (pack-ice, land, and land-fast ice) and the general geographic area of previous dens. Bears denning on land may be vunerable to human activities such as hunting and industrial development. However, predictable denning chronology and alck of site fidelity indicate that many potential impacts on denning polar bears could be mitigated.

  9. Leadership pipeline i den offentlige sektor

    DEFF Research Database (Denmark)

    Dahl, Kristian Aagaard; Molly-Søholm, Thorkil

    en rejse ind i hjertet af offentlig ledelse med fokus på lederniveauerne: topchef, funktionel chef, leder af ledere og leder af medarbejdere. Med afsæt i righoldige eksempler og fortællinger fra virkeligheden introduceres læseren for ledelsesteorien den Offentlige Leadership Pipeline, som giver...... enkelte lederniveauer og udvikle ledertalenter. Teorien byder på et detaljeret ledelsesgrundlag, hvorudfra den offentlige organisation kan bygge en professionel værdikæde for ledelse ved at forme lederprofiler, -rekruttering, -uddannelse, -evaluering m.m. Leadership Pipeline i den offentlige sektor er...... baseret på et treårigt dansk praksisorienteret forskningsprojekt med deltagelse af 15 offentlige organisationer, som repræsenterer kommunerne, regionerne og staten. Projektet har videreudviklet en af de sidste 10 års mest indflydelsesrige ledelseteorier i de største private organisationer, Leadership...

  10. Den kontraktstyrede og kontraktstyrende offentlige sektor

    DEFF Research Database (Denmark)

    Schulze, Christiane; Greve, Carsten

    Kontraktbaseret styring har været på den politiske agenda i OECD landene siden de tidlige 1980’erne og i dag er kontrakter et helt centralt element i den moderne regering ((Ejersbo & Greve 2005: 62, Greve 2008a: 4). Internationalt var det især med Reagon-regeringen i USA og Thatcher-regeringen i...... den private sektor og [som] brug af markedsmekanismer”(Greve 2003). Ved siden af privatisering og deregulering iagttages kontrakter som et determinerende element i NPM (Fortin 2000:1). Kontrakter kan helt grundlæggende defineres som en aftale mellem bestiller og leverandør, der angiver vilkårene...

  11. Den empiriske uddannelsesvidenskab og kvalitet i studieaktivitet

    DEFF Research Database (Denmark)

    Keiding, Tina Bering; Qvortrup, Ane

    2015-01-01

    Bidraget kobler studieaktivitetesmodellen med kvalitetsindikatorer for god undervisning, og viler blandt andet, hvorledes modellen kan støtte samtænkning af forskellige undervisnings- og læringsformater med henblik på øge den aktive læretid......Bidraget kobler studieaktivitetesmodellen med kvalitetsindikatorer for god undervisning, og viler blandt andet, hvorledes modellen kan støtte samtænkning af forskellige undervisnings- og læringsformater med henblik på øge den aktive læretid...

  12. Dragons' Den: promoting healthcare research and innovation.

    Science.gov (United States)

    Mazhindu, Deborah; Gregory, Siobhan

    2015-07-01

    The changing health and social care landscape, and, in particular, the financial challenges affecting the NHS, can present difficulties for staff looking for funding to support innovation and new ways of working. One method of competitive tendering that is becoming more accepted as a way of allocating funds, encouraging staff engagement and developing innovation for research is a format based the BBC television series, Dragons' Den. This article describes how Hounslow and Richmond Community Healthcare NHS Trust, London, has developed a 'Dragons' Den initiative' of annual competitive research funding allocation to ensure that some of the most dynamic practice in the trust is captured.

  13. Das Bild behinderter Menschen in den Medien

    OpenAIRE

    Radtke, Peter

    2006-01-01

    „Das Bild von Behinderung und behinderten Menschen in den Medien“ - dieses Thema führt sehr leicht zur Schwarz-Weiß-Malerei. Bekanntlich fällt es schwer, es allen recht zu machen. So nimmt es nicht Wunder, dass sich Betroffene und ihre Angehörigen in den Medien sowohl quantitativ als auch qualitativ oftmals nicht angemessen repräsentiert fühlen. [...] In dieser Situation bilden die Medien die wichtigste und oft einzige Informationsquelle über das Leben und die Möglichkeiten von Menschen mit e...

  14. Preoperative imaging of charcot neuroarthropathy. Does the additional application of 18F-FDG-PET make sense?

    International Nuclear Information System (INIS)

    Hoepfner, S.; Krolak, C.; Kessler, S.; Tiling, R.

    2006-01-01

    With about 4 million diabetics in Germany and presumed inclination over the following years the treatment of diabetic complications like diabetic foot will become an even more important point. The management of Charcot's foot has undergone fundamental change in the last few years. Formerly, treatment was almost exclusively limited to non surgical measures; since the late 1990's, however, current practice has shifted to early, stage-appropriate surgical therapy. The aim of the present prospective study was to investigate the value of positron emission tomography (PET) in the pre-operative work-up of Charcot's foot. PET were compared to magnetic resonance tomography (MRI). Patients, methods: MRI and PET imaging were used as part of the preoperative work-up in 18 patients with Type II diabetes mellitus. The diagnosis of Charcot's foot requiring surgical treatment were made on the basis of clinical and radiologic criteria. Results: of 46 Charcot's lesions confirmed at surgery, 44 and 35 were detected by means of PET and MRI, respectively. PET can be used in the work-up of patients with metal implants where the MRI does not show adequate findings. PET shows the areas of detritus formation exhibit only moderately increased glucose metabolism and at visual interpretation do not usually impress as typical for acute osteomyelitis. Average SUV values stood at 1.2 (range: 0.5-2.9). Conclusions: the differentiation between Charcot's lesions and floride osteomyelitis provides the surgeon with important additional information, which is often unavailable from MRI. Because of this important additional data, PET could be considered preferable to morphologic imaging (CT, projection radiography) in the preoperative work-up of Charcot's foot. (orig.)

  15. Preoperative imaging of charcot neuroarthropathy. Does the additional application of {sup 18}F-FDG-PET make sense?

    Energy Technology Data Exchange (ETDEWEB)

    Hoepfner, S. [Abt. fuer Diagnostische Radiologie, Universitaetsklinikum Giessen und Marburg, Standort Giessen (Germany); Krolak, C. [Inst. fuer Klinische Radiologie, Klinikum der Ludwig-Maximilians-Univ. Muenchen (Germany); Kessler, S. [Chirurgische Klinik und Poliklinik, Klinikum der Ludwig-Maximilians-Univ. Muenchen (Germany); Tiling, R. [Klinik und Poliklinik fuer Nuklearmedizin, Klinikum der Ludwig-Maximilians-Univ. Muenchen (Germany)

    2006-07-01

    With about 4 million diabetics in Germany and presumed inclination over the following years the treatment of diabetic complications like diabetic foot will become an even more important point. The management of Charcot's foot has undergone fundamental change in the last few years. Formerly, treatment was almost exclusively limited to non surgical measures; since the late 1990's, however, current practice has shifted to early, stage-appropriate surgical therapy. The aim of the present prospective study was to investigate the value of positron emission tomography (PET) in the pre-operative work-up of Charcot's foot. PET were compared to magnetic resonance tomography (MRI). Patients, methods: MRI and PET imaging were used as part of the preoperative work-up in 18 patients with Type II diabetes mellitus. The diagnosis of Charcot's foot requiring surgical treatment were made on the basis of clinical and radiologic criteria. Results: of 46 Charcot's lesions confirmed at surgery, 44 and 35 were detected by means of PET and MRI, respectively. PET can be used in the work-up of patients with metal implants where the MRI does not show adequate findings. PET shows the areas of detritus formation exhibit only moderately increased glucose metabolism and at visual interpretation do not usually impress as typical for acute osteomyelitis. Average SUV values stood at 1.2 (range: 0.5-2.9). Conclusions: the differentiation between Charcot's lesions and floride osteomyelitis provides the surgeon with important additional information, which is often unavailable from MRI. Because of this important additional data, PET could be considered preferable to morphologic imaging (CT, projection radiography) in the preoperative work-up of Charcot's foot. (orig.)

  16. Den udødelige gangster

    DEFF Research Database (Denmark)

    Bjerre, Thomas Ærvold

    2009-01-01

    Hollywood har igennem et århundrede hyldet de voldspsykopater, som de fleste gangstere nu engang er. Michael Manns Public Enemies er seneste skud på stammen i den lange række af amerikanske gangsterfilm, der tog sin begyndelse i starten af 1930'erne, og som meget hurtig blev til en mytisk...

  17. Den skrøbelige sandhed

    DEFF Research Database (Denmark)

    Pedersen, Peter Ole

    2010-01-01

    Artiklen retter fokus mod de seneste års udvikling af den aktivistiske dokumentarfilm. Med analytiske punktnedslag hos instruktørerne Michael Moore, Morgan Spurlock, Dylan Avery, Robert Greenwald og Mauro Andrizzi undersøges de forbindelser der eksisterer mellem udtrykket i de populære spillefilm...

  18. Joop van den Bremen, Streektaalmuziek in Nederland

    NARCIS (Netherlands)

    A.J.C. van der Hoeven (Arno)

    2015-01-01

    textabstractIn 1996, folk music fan Joop van den Bremen started his website Streektaalmuziek in Nederland (“Regional language music in the Netherlands”).1 On this website he collects information on Dutch musicians singing in dialect.2 As of September 2014, his still expanding database contains 6,164

  19. Digital kommunikation med den offentlige sektor

    DEFF Research Database (Denmark)

    Berger, Jesper Bull; Andersen, Kim Normann

    , som enten via spørgeskema, e-mail eller telefon har givet os et enestående indblik i deres håndtering af den digitale kommunikation. Publikationen er et såkaldt workingpaper, hvor vi mere end gerne modtager forslag og kommentarer til forbedringer. Der er i publikationen en række aktive links til...

  20. Nyliberalisme, universiteter og den akademiske frihed

    DEFF Research Database (Denmark)

    Madsen, Mogens Ove

    2011-01-01

    Den akademiske frihed er forbundet med absolut frihed til at frembringe og videreformidle viden. Denne ide med universitetet er blevet udfordret ganske kraftigt i de senere år, ikke kun i Danmark. Stærke rådgivningsinstitutioner som OECD og EU har i en del år anbefalet, at universiteternes opgave...

  1. Tre teorier om den moralske udvikling

    DEFF Research Database (Denmark)

    Bo, Inger Glavind; Andreasen, Brian Kjær

    I artiklen gennemgås tre forskellige men teorihistorisk relaterede perspektiver på forståelsen af moralsk udvikling: Piaget, Kohlberg og Gilligan. I den efterfølgende diskussion af disse teoretikeres respektive positioner påpeges såvel forskelle som ligheder i deres betoning af moralens karakter...

  2. Christian Birch - den korrupte konferensråd

    DEFF Research Database (Denmark)

    Jensen, Mette Frisk

    2005-01-01

      http://www.sidensaxo.dk/fileadmin/saxo-abstract-uploads/christian_birch_den_korrupte_konferensraad_2005_3.pdf......  http://www.sidensaxo.dk/fileadmin/saxo-abstract-uploads/christian_birch_den_korrupte_konferensraad_2005_3.pdf...

  3. 'Welzijnsvloer verdient zich op den duur terug'; van den Berg beproeft de groene vlag roostervloer

    NARCIS (Netherlands)

    Anoniem,

    2010-01-01

    Het onderzoek van Wageningen UR naar de welzijnsvloeren is nog in volle gang. Maar vleeskalverhouder Wijnand van den Berg uit Kootwijkerbroek heeft op eigen initiatief al een welzijnsrooster in zijn stal op proef

  4. Premolarized double dens in dente in albinism - A case report

    Directory of Open Access Journals (Sweden)

    Suprabha B

    2005-09-01

    Full Text Available Dens in dente are known to be associated with many dental abnormalities such as taurodontism microdontia, gemination, and dens evaginatus. This paper describes a rare case of double dens in dente in a lateral incisor with crown morphology similar to a premolar present in a patient with features of albinism. Problems associated with this condition and their management is discussed.

  5. Ueber die arten und den Skelettbau von Culcita

    NARCIS (Netherlands)

    Hartlaub, Clemens

    1892-01-01

    Das Genus Culcita Agass. zählt durch die merkwürdige Form und die ansehnliche Grösse seiner Arten zu den interessantesten Asteriden, und gut conservirte Exemplare davon gehören zu den Zierden unsrer Museen. Um so bedauerlicher erschien es mir, als ich vor einiger Zeit den Versuch machte die von

  6. Human disturbances of denning polar bears in Alaska

    International Nuclear Information System (INIS)

    Amstrup, S.C.

    1993-01-01

    Polar bears (Ursus maritimus) give birth in dens of snow and ice. The altricial neonates cannot leave the den for >2 months post-partum and are potentially vulnerable to disturbances near dens. The coastal plain (1002) area of Alaska's Arctic National Wildlife Refuge (ANWR) lies in a region of known polar bear denning and also may contain >9 billion barrels of recoverable oil. Polar bears in dens could be affected in many ways by hydrocarbon development. The distribution of dens on ANWR was documented between 1981 and 1992 and responses of bears in dens to various anthropogenic disturbances were observed. Of 44 dens located by radiotelemetry on the mainland coast of Alaska and Canada, 20 (45%) were on ANWR and 15 (34%) were within the 1002 area. Thus, development of ANWR will increase the potential that denning polar bears are disturbed by human activities. However, perturbations resulting from capture, marking, and radiotracking maternal bears did not affect litter sizes or stature of cubs produced. Likewise, 10 of 12 denned polar bears tolerated exposure to exceptional levels of activity. This tolerance and the fact that investment in the denning effort increases through the winter indicated that spatial and temporal restrictions on developments could prevent the potential for many disruptions of denned bears from being realized. 16 refs., 1 fig., 2 tabs

  7. [Von den Restgütern zu den Sowchosen in Estland 1939-1953. Dokumentensammlung] / Olev Liivik

    Index Scriptorium Estoniae

    Liivik, Olev, 1975-

    2011-01-01

    Arvustus: Von den Restgütern zu den Sowchosen in Estland 1939-1953 : Dokumentensammlung / Hrsg. von David Feest, Karsten Brüggemann. Berlin : Lit Verlag, 2010. (Schriften der Baltischen historischen Kommission ; Bd. 15)

  8. Psychometrics evaluation of Charcot-Marie-Tooth Neuropathy Score (CMTNSv2) second version, using Rasch analysis.

    Science.gov (United States)

    Sadjadi, Reza; Reilly, Mary M; Shy, Michael E; Pareyson, Davide; Laura, Matilde; Murphy, Sinead; Feely, Shawna M E; Grider, Tiffany; Bacon, Chelsea; Piscosquito, Giuseppe; Calabrese, Daniela; Burns, Ted M

    2014-09-01

    Charcot-Marie-Tooth Neuropathy Score second version (CMTNSv2) is a validated clinical outcome measure developed for use in clinical trials to monitor disease impairment and progression in affected CMT patients. Currently, all items of CMTNSv2 have identical contribution to the total score. We used Rasch analysis to further explore psychometric properties of CMTNSv2, and in particular, category response functioning, and their weight on the overall disease progression. Weighted category responses represent a more accurate estimate of actual values measuring disease severity and therefore could potentially be used in improving the current version. © 2014 Peripheral Nerve Society.

  9. An Overview of Internal and External Fixation Methods for the Diabetic Charcot Foot and Ankle.

    Science.gov (United States)

    Ramanujam, Crystal L; Zgonis, Thomas

    2017-01-01

    Diabetic Charcot neuroarthropathy (DCN) of the foot and ankle is a challenging disease with regard to clinical presentation, pathogenesis, and prognosis. Its surgical management is equally difficult to interpret based on the wide array of options available. In the presence of an ulceration or concomitant osteomyelitis, internal fixation by means of screws, plates, or intramedullary nailing needs to be avoided when feasible. External fixation becomes a great surgical tool when managing DCN with concomitant osteomyelitis. This article describes internal and external fixation methods along with available literature to enlighten surgeons faced with treating this complex condition. Copyright © 2016 Elsevier Inc. All rights reserved.

  10. Criteria of immobilization duration of the affected foot in diabetic Charcot neuro-osteoarthropathy

    Directory of Open Access Journals (Sweden)

    Anastasia Gennad'evna Demina

    2014-10-01

    Full Text Available Long-term offloading is the key factor in the treatment of the acute stage of Charcot foot. The indication for remobilization and transition of the affected foot to weight-bearing activities is believed to be based on two factors: the absence of the clinical signs of inflammation and results of the objective diagnostic tests. At the present time, consensus about appropriate methods sufficient for initiating weight-bearing activities after immobilization is absent. This paper discusses current data on clinical and laboratory tests and methods and describes their advantages and disadvantages.

  11. Salient features and outcomes of Charcot foot – An often-overlooked diabetic complication: A 17-year-experience at a diabetic center in Bangkok

    Directory of Open Access Journals (Sweden)

    Yotsapon Thewjitcharoen

    2018-03-01

    Full Text Available Background: Charcot foot is a rare but a serious diabetic condition. Recognition of this often overlooked condition to provide timely and proper management is important for a better prognosis. Limited data on Charcot foot was available in Asians. Aims: The aim of this study is to describe salient features and outcomes of Charcot foot in Thai patients. Method: We presented our experience of 40 cases of Charcot foot patients who were treated from 2000 to 2016 at Theptarin Hospital, Bangkok, Thailand. Results: A total of 40 Charcot foot patients were identified (13 acute, 27 chronic; mean age 58.7 ± 10.2 years; duration of diabetes 18.0 ± 8.8 years; T2DM 95%. The average serum HbA1c level was 9.2 ± 1.9%. While acute Charcot foot was frequently misdiagnosed as cellulitis in almost one-third of patients, osteomyelitis was a leading cause of misdiagnosis in 15% of chronic Charcot foot patients. Ulcer-free rate at 6 and 12 months were observed in 60% and 58% of patients, respectively. The mortality rate was 13% during a median follow-up period of 57 months. Only 61% of the patients resumed walking normally while almost one-fourth of them were wheelchair-bound. Conclusions: Charcot foot in Thai patients mainly developed in long-standing poorly controlled type 2 diabetes with neuropathy, and presented late in the course of the disease. It was often misdiagnosed resulting in improper management and poor outcome which included amputation. Keywords: Charcot foot, Outcomes, Thailand

  12. [Charcot, working and 'Male Hysteria': A new approach to the Leçons du mardi (Tuesday Lessons) from the standpoint of psychodynamics of work].

    Science.gov (United States)

    Molinier, Pascale

    2015-01-01

    This paper examines the role of work in Charcot's clinical teaching focusing on cases of male hysteria in The Tuesday's Lessons from 1887 to 1889. Today, we read the work of Charcot in a retrospective way as having ended in a failure: He would have missed the discovery of the sexual unconscious. From the perspective of psychodynamics of work, it appears an alternative way which was present in Charcot, though unfinished, opening on a possible development of a relationship between psychic and body. The role of work in traumatic hysteria has been forgotten by Freud's posterity and this obliteration continues today.

  13. Jamie Oliver i den gode smags tjeneste

    DEFF Research Database (Denmark)

    Leer, Jonatan

    2014-01-01

    det gode liv er i stigende grad blevet en central del af genren i dag, hvor særligt kogebogsforfatternes privatliv og livsstil – altså et selvbiografisk element – er blevet et bærende narrativ i mange kogebøger. Med sådanne iscenesættelser og dramatiseringer af forestillinger om det gode liv bevæger...... den gode sags tjeneste først og fremmest tjener til at skabe et positivt billede af tv-kokken/kogebogsforfatteren som etisk individ (og brand) på bekostning af de gastronomisk nødstedte. Det skal nævnes, at jeg i min læsning af Jamies kogebogs-kampskrift har ladet mig inspirere af den russisk...

  14. Stephen Schwartz og den folkelige lyd

    DEFF Research Database (Denmark)

    Kreutzfeldt, Jacob

    2013-01-01

    Stephen Schwartz døde i foråret 2013. I denne artikel forsøger Jacob Kreutzfeldt, der gennemførte en række interviews med Schwartz gennem hans sidste år, at indkredse den æstetiske grundholdning, der prægede hans arbejde med radiomontagen i DR.......Stephen Schwartz døde i foråret 2013. I denne artikel forsøger Jacob Kreutzfeldt, der gennemførte en række interviews med Schwartz gennem hans sidste år, at indkredse den æstetiske grundholdning, der prægede hans arbejde med radiomontagen i DR....

  15. Dens Evaginatus: A Problem-Based Approach

    Directory of Open Access Journals (Sweden)

    A. Ayer

    2015-01-01

    Full Text Available Dens evaginatus is an uncommon developmental anomaly of human dentition characterized by the presence of tubercle on the occlusal surface of mandibular premolars and lingual surface of anterior teeth. Due to occlusal trauma this tubercle tends to fracture thus exposing the pathway to the pulp chamber of teeth. This case report is about the presentation of dens evaginatus in mandibular premolars bilaterally; among them tooth 44 was associated with chronic apical periodontitis. Fractured tubercle of three premolars was sealed with composite resin. Root canal treatment was performed with tooth 44. Routine endodontic treatment did not result in remission of infection. Therefore, culture and sensitivity tests were performed to identify the cause and modify treatment plan accordingly. Triple antibiotic paste was used as an intracanal medicament to disinfect the root canal that resulted in remission of infection.

  16. Quantitative measurement of duplicated DNA as a diagnostic test for Charcot-Marie-Tooth disease type 1a

    NARCIS (Netherlands)

    Hensels, G. W.; Janssen, E. A.; Hoogendijk, J. E.; Valentijn, L. J.; Baas, F.; Bolhuis, P. A.

    1993-01-01

    Charcot-Marie-Tooth disease type 1 (CMT1) is a hereditary motor and sensory neuropathy. The autosomal dominant subtype is often linked with a large duplication on chromosome 17p11.2. The gene encoding the peripheral myelin protein PMP 22 (the critical gene in this subtype of CMT1) is located within

  17. Charcot-Marie-Tooth disease type 1A: morphological phenotype of the 17p duplication versus PMP22 point mutations

    NARCIS (Netherlands)

    Gabreëls-Festen, A. A.; Bolhuis, P. A.; Hoogendijk, J. E.; Valentijn, L. J.; Eshuis, E. J.; Gabreëls, F. J.

    1995-01-01

    Charcot-Marie-Tooth disease type 1A (CMT1A) or hereditary motor and sensory neuropathy type Ia (HMSN type Ia) is an autosomal dominant demyelinating polyneuropathy, which may result from duplications as large as 1.5 Mb on chromosome 17p 11.2-p12 encompassing the gene for the peripheral myelin

  18. PMP22 related neuropathies: Charcot-Marie-Tooth disease type 1A and Hereditary Neuropathy with liability to Pressure Palsies

    NARCIS (Netherlands)

    van Paassen, Barbara W.; van der Kooi, Anneke J.; van Spaendonck-Zwarts, Karin Y.; Verhamme, Camiel; Baas, Frank; de Visser, Marianne

    2014-01-01

    PMP22 related neuropathies comprise (1) PMP22 duplications leading to Charcot-Marie-Tooth disease type 1A (CMT1A), (2) PMP22 deletions, leading to Hereditary Neuropathy with liability to Pressure Palsies (HNPP), and (3) PMP22 point mutations, causing both phenotypes. Overall prevalence of CMT is

  19. The first de novo mutation of the connexin 32 gene associated with X linked Charcot-Marie-Tooth disease

    NARCIS (Netherlands)

    Meggouh, F.; Benomar, A.; Rouger, H.; Tardieu, S.; Birouk, N.; Tassin, J.; Barhoumi, C.; Yahyaoui, M.; Chkili, T.; Brice, A.; LeGuern, E.

    1998-01-01

    X linked Charcot-Marie-Tooth disease (CMTX) is a hereditary motor and sensory neuropathy caused by mutations in the connexin 32 gene (Cx32). Using the SSCP technique and direct sequencing of PCR amplified genomic DNA fragments of the Cx32 gene from a Moroccan patient and her relatives, we identified

  20. The natural history of Charcot-Marie-Tooth type 1A in adults: a 5-year follow-up study

    NARCIS (Netherlands)

    Verhamme, Camiel; van Schaik, Ivo N.; Koelman, Johannes H. T. M.; de Haan, Rob J.; de Visser, Marianne

    2009-01-01

    Charcot-Marie-Tooth type 1A is the most prevalent hereditary demyelinating polyneuropathy. The aim of this study was to investigate the natural history of the disease in adults during a 5-year follow-up and to compare the changes over time with those found in normal ageing. In a cohort of 46 adult

  1. Copy Number Variations in a Population-Based Study of Charcot-Marie-Tooth Disease

    Directory of Open Access Journals (Sweden)

    Helle Høyer

    2015-01-01

    Full Text Available Copy number variations (CNVs are important in relation to diversity and evolution but can sometimes cause disease. The most common genetic cause of the inherited peripheral neuropathy Charcot-Marie-Tooth disease is the PMP22 duplication; otherwise, CNVs have been considered rare. We investigated CNVs in a population-based sample of Charcot-Marie-Tooth (CMT families. The 81 CMT families had previously been screened for the PMP22 duplication and point mutations in 51 peripheral neuropathy genes, and a genetic cause was identified in 37 CMT families (46%. Index patients from the 44 CMT families with an unknown genetic diagnosis were analysed by whole-genome array comparative genomic hybridization to investigate the entire genome for larger CNVs and multiplex ligation-dependent probe amplification to detect smaller intragenomic CNVs in MFN2 and MPZ. One patient had the pathogenic PMP22 duplication not detected by previous methods. Three patients had potentially pathogenic CNVs in the CNTNAP2, LAMA2, or SEMA5A, that is, genes related to neuromuscular or neurodevelopmental disease. Genotype and phenotype correlation indicated likely pathogenicity for the LAMA2 CNV, whereas the CNTNAP2 and SEMA5A CNVs remained potentially pathogenic. Except the PMP22 duplication, disease causing CNVs are rare but may cause CMT in about 1% (95% CI 0–7% of the Norwegian CMT families.

  2. Reliability of the CMT neuropathy score (second version) in Charcot-Marie-Tooth disease.

    LENUS (Irish Health Repository)

    Murphy, Sinéad M

    2011-09-01

    The Charcot-Marie-Tooth neuropathy score (CMTNS) is a reliable and valid composite score comprising symptoms, signs, and neurophysiological tests, which has been used in natural history studies of CMT1A and CMT1X and as an outcome measure in treatment trials of CMT1A. Following an international workshop on outcome measures in Charcot-Marie-Tooth disease (CMT), the CMTNS was modified to attempt to reduce floor and ceiling effects and to standardize patient assessment, aiming to improve its sensitivity for detecting change over time and the effect of an intervention. After agreeing on the modifications made to the CMTNS (CMTNS2), three examiners evaluated 16 patients to determine inter-rater reliability; one examiner evaluated 18 patients twice within 8 weeks to determine intra-rater reliability. Three examiners evaluated 63 patients using the CMTNS and the CMTNS2 to determine how the modifications altered scoring. For inter- and intra-rater reliability, intra-class correlation coefficients (ICCs) were ≥0.96 for the CMT symptom score and the CMT examination score. There were small but significant differences in some of the individual components of the CMTNS compared with the CMTNS2, mainly in the components that had been modified the most. A longitudinal study is in progress to determine whether the CMTNS2 is more sensitive than the CMTNS for detecting change over time.

  3. Den danske fødevaresektor

    DEFF Research Database (Denmark)

    Bosselmann, Aske Skovmand; Gylling, Morten

    2012-01-01

    Den danske fødevaresektor har et højt niveau for så vidt angår miljø og bæredygtighed. Der kan være et potentiale for vækst og beskæftigelse i at bruge dette relativt høje niveau til at give danske virksomheder adgang til attraktive eksportmarkeder, hvor fødevarer, der er dokumenteret bæredygtige...

  4. Open Access og Den Bibliometriske Forskningsindikator

    DEFF Research Database (Denmark)

    Dorch, Bertil

    2011-01-01

    I sine "Anbefalinger til implementering af Open Access i Danmark" foreslår det nationale Open Access Udvalget blandet andet, at Den Bibliometriske Forskningsindikator (BFI) bør koordineres med en national Open Access-politik. I dette paper, der er baseret på et blogindlæg, fremfører forfatteren...... fire grunde til, hvorfor han synes det er en dårlig idé at koble Open Access til BFI....

  5. Injury Biomechanics of C2 Dens Fractures

    OpenAIRE

    Yoganandan, Narayan; Pintar, Frank; Baisden, Jamie; Gennarelli, Thomas; Maiman, Dennis

    2004-01-01

    The objective of this study is to analyze the biomechanics of dens fractures of the second cervical vertebra in the adult population due to motor vehicle crashes. Case-by-case records from the Crash Injury Research and Engineering Network (CIREN) and National Automotive Sampling System (NASS) databases were used. Variables such as change in velocity, impact direction and body habitus were extracted. Results indicated that similarities exist in the two databases despite differences in sampling...

  6. Simultaneous Occurrence of Dens Invaginatus and Fusion

    Directory of Open Access Journals (Sweden)

    Amit Mhapuskar

    2013-01-01

    Full Text Available Although Dens invaginatus and fusion are well-known and well established dental anomalies, they are rarely seen in supernumerary teeth. In this article, simultaneous occurrence of Dens invaginatus and fusion between maxillary lateral incisor and a supernumerary tooth is described. Dens invaginatus is clinically significant due to the possibility of the pulpal involvement; pulpitis, necrotic pulps and chronic periapical lesions are often associated with this anomaly without clinical symptoms. Fusion has a negative impact on the aesthetics, especially when it occurs in maxillary anterior teeth. It is difficult to clinically make differential diagnosis between fused teeth and geminated teeth, especially when these anomalies take place together with hypodontia or supernumerary tooth. It has been found that sequel of such teeth may result in delayed eruption, ectopic eruption or even impaction of permanent teeth; hence proper diagnosis by clinical and radiographic methods and intervention at appropriate time is of paramount importance. The accurate knowledge of variations in morphology of tooth and pulp cavity greatly assists the dentist in planning successful treatment options.

  7. Digital kommunikation med den offentlige sektor

    DEFF Research Database (Denmark)

    Berger, Jesper; Andersen, Kim Normann

    2013-01-01

    Denne rapport sammenfatter hovedresultaterne af en undersøgelse gennemført i juni måned 2013 om besvarelse af e-mail og digital post i den statslige, regionale og kommunale sektor. Allerede med eDag3 1. nov. 2010 skulle alle myndigheder have oprettet en digital postkasse, som borgerne kunne skrive...... til. I denne undersøgelse sættes der fokus på myndighedernes besvarelse af den digitale post. Digital post blev bl.a. etableret som et alternativ til almindelig e-mail for at det offentlige kan kommunikere med borgere og virksomheder på en sikker måde, dvs. uden at uvedkommende kan få adgang til...... følsomme oplysninger. Fokus for undersøgelsen er hvordan håndterer myndighederne besvarelserne i den digitale postkasse: svarer de på digital post og e-mail, hvor hurtigt svarer de og er svarene brugbare? Undersøgelsen medtager myndighedernes besvarelse af digital post og e-mail, dels for at kunne...

  8. Digital kommunikation med den offentlige sektor

    DEFF Research Database (Denmark)

    Berger, Jesper Bull; Andersen, Kim Normann

    Denne rapport sammenfatter hovedresultaterne for styrelser og statslige organisationer af en undersøgelse gennemført i sommeren 2013 om besvarelse af e-mail og digital post i den statslige, regionale og kommunale sektor. Allerede med eDag3 1. nov. 2010 skulle alle myndigheder have oprettet en...... digital postkasse, som borgerne kunne skrive til. I denne undersøgelse sættes der fokus på myndighedernes besvarelse af den digitale post. Digital post blev bl.a. etableret som et alternativ til almindelig e-mail for at det offentlige kan kommunikere med borgere og virksomheder på en sikker måde, dvs....... uden at uvedkommende kan få adgang til følsomme oplysninger. Fokus for undersøgelsen er hvordan håndterer myndighederne besvarelserne i den digitale postkasse: svarer de på digital post og e-mail, hvor hurtigt svarer de og er svarene brugbare? Vi har også undersøgt besvarelse af e-mail, dels...

  9. Dens evaginatus and dens invaginatus in a double tooth: A rare case report

    Directory of Open Access Journals (Sweden)

    Gaurav Sharma

    2015-01-01

    Full Text Available The presence of dens invaginatus (DI and dens evaginatus (DE on same tooth is a rare phenomenon. However, when these dental anomalies occur on a double tooth, it becomes an extremely rare phenomenon. The authors report a rare case of DI and DE on fused permanent maxillary central incisor with supernumerary tooth in a 40-year-old male. The present article also focuses on the differentiating fusion from gemination and also reviews preventive and management strategies for tooth with complex dental anatomy.

  10. Droht den "kleinen Sprachen" das Aussterben?

    Directory of Open Access Journals (Sweden)

    Anita Lemić

    2014-12-01

    Full Text Available Die Prozesse der Globalisierung sind die Ursache für viele Änderungen in der Weltgemeinschaft, vor allem die Entfernung von Unterscheidungsmerkmalen (in Bezug darauf, dass „zwischen vielen ethnischen Zeichen, das was dauernd ist, ist die Dichotomisierung/Differenzierung eines „Wir-und-die-Anderen“ (Grbić, 2003, 93-64. Diese Zeichen wirken als Zeichen der Resozialisierung, die die bestehenden Identitäten löschen und sich an der Schaffung neuer Strukturen beteiligen. Die Zeit der Romantik in Europa ermöglichte die Schaffung von Nationalstaaten und ihr Hauptmerkmal war die Nationalsprache. Diese Art der sozialen Differenzierung hatte das Ziel, die Illusion einer vollständig homogenisierten Gesellschaft zu schaffen und damit den Prozess der Zerstörung der „kleinen“ Sprachen zu beginnen. Sprache und Kultur erwiesen sich als Grundlage der Gemeinschaftserhaltung. Die Homogenisierung ermöglicht Aktivitäten mit dem Ziel, einem Individuum zu helfen, sich als Individuum und als Mitglied der Gemeinschaft zu behaupten. Keine dieser beiden Identitäten kann ohne die Wechselwirkung mit der Umgebung erreicht werden. Die sprachliche Interaktion mit anderen Mitgliedern ist das Schlüsselsegment, das Menschen von anderen Lebensformen unterscheidet. Durch den Austausch von Erfahrungen mit anderen kommt der Mensch auf allen Ebenen voran und mit der Erfindung der Schrift öffnete er die Tür zur Entwicklung der Zivilisation. In dieser Arbeit beschäftigen wir uns mit der Frage der „Prestige“-Sprachen, die auf der Grundlage der Macht der Gemeinschaft der Muttersprachler ihren Bereich weit über die Grenzen des eigenen Landes hinaus erweitern und so eine politische und wirtschaftliche Vormachtstellung schaffen, aber auch mit den Auswirkungen jener Sprachen auf die Dekonstruktion oder möglicherweise vollständige Ausrottung der Sprachen, die auf diese Weise an Einfluss verlieren, unmodern werden und sich die Frage der Notwendigkeit ihrer

  11. Den danske ROSE-undersøgelse

    DEFF Research Database (Denmark)

    Andersen, Annemarie Møller; Allerup, Peter; Arnvig, Birgitte

    ROSE (Relevance of Science Education) er en international komparativ undersøgelse af 15-åriges holdninger til og interesse for naturfagsundervisning, naturvidenskab og teknologi med deltagelse af ca. 40. lande. Dataindsamlingen til den danske del af ROSE-undersøgelsen blev gennemført i 2003....... Antologien giver et overblik over  og forskellige perspektiver på de danske 15-åriges besvarelser af de ca. 280 spørgsmål i det danske ROSE-skema....

  12. Transnational organisatorisk innovation i den offentlige sektor

    DEFF Research Database (Denmark)

    Hansen, Morten Balle

    Artiklen undersøger tre problemstillinger: 1) Hvor udbredt er forskellige former for transnational organisatorisk innovation i den danske offentlige sektor? 2) Hvordan er disse organisatoriske innovationer relateret til hinanden? 3) Er forskelle i deres udbredelse signifikant relateret til...... innovation og dels på forskelle og ligheder mellem statslige og kommunale organisationer. Elleve former for organisatorisk innovation, hvoraf mange ofte forbindes med New Public Management (NPM), er inkluderet i de empiriske analyser: Privatisering/udlicitering, Bestiller-Udfører model, Kontraktstyring, Mål...

  13. Fusion og koncentration i den danske svineslagterisektor

    DEFF Research Database (Denmark)

    Hansen, Henning Otte

    2015-01-01

    Strukturudviklingen i den danske slagterisektor er gået hurtig i de seneste ti-år. Koncentrationen steg kraftigt efter midten af 1980‘erne, men i de sidste 10-15 år er udviklingen i et vist omfang stagneret eller endog vendt, og koncentrationen har været faldende. En evt. fusion mellem Danish Crown...... og Tican vil sandsynligvis ikke opveje dette fald i koncentration. De historiske erfaringer fra sektoren viser endvidere, at virksomheder efter en fusion ofte taber markedsandele. Markedet for svinekød er blevet langt mere internationaliseret i de senere år, og dette alene vil øge konkurrencen....

  14. Zoologien i den klassiske islamiske kultur

    OpenAIRE

    Provencal, Philippe; Aarab, Ahmed

    2014-01-01

    Denne artikel bringer en oversigt over forskning i den zoologiske videnskab, således som denne er kommet til udtryk i tekster skrevet på klassisk arabisk fra anden halvdel af 700-tallet til 1400-tallet. I lyset af nyere forskning og med eksempler hentet fra de arabiske tekster selv, bliver en ny bedømmelse af disse teksters faglige indhold foreslået. This article brings a survey of research on the science of zoology in the Classical Arabic/Islamic Culture as revealed in texts on this subje...

  15. Denning behaviour of non-gravid wolves, Canis lupus

    Science.gov (United States)

    Mech, L.D.; Phillips, M.K.; Smith, D.W.; Kreeger, T.J.

    1996-01-01

    Wild wolves (Canis lupus) that had produced pups in earlier years but were not currently pregnant, and ovariectomized captive wolves, dug dens during and after the whelping season even though they produced no pups. These observations suggest that den digging is not a function of pregnancy or of ovarian estrogen or progesterone. We hypothesize that increasing prolactin in spring elicits or mediates den-digging behavior.

  16. Den skjulte Oldtid – den nye udstilling på Nationalmuseet

    DEFF Research Database (Denmark)

    Ingemann, Bruno

    2009-01-01

    Enhver udstilling konstruerer sin besøgende! Man skal som besøgende have bestemte forudsætninger, en vis viden, kende bestemte kategorier, have en bestemt form for nysgerrighed – og det er udstillingen som skaber dette særsprog med dets muligheder for at udelukke eller inkludere den besøgende. De...

  17. Konservatismen og den højreradikale terror

    DEFF Research Database (Denmark)

    Skov, Christian Houlberg

    2011-01-01

    Den norske højreekstremist Anders Behring Breiviks terror mod det norske samfund har herhjemme ledt til en voldsom debat om blandt andet forbindelsen mellem tonen i debatten og terrorangrebet og forholdet mellem den siden 2001 meget omtalte kulturkonservatisme og Anders Breiviks terrorhandling....... Essayet Konservatismen og den højreradikale terror forsøger dels at skabe klarhed over fronterne i debatten, dels at rette en kritik mod såvel tendensen til at afskrive handlingen som uforståelig som af tendensen til at slå den bredere højrefløjs kritik af multikulturalismen i hartkorn med Breiviks...

  18. Mozart, Karl Barth, og den kristne troslæren

    DEFF Research Database (Denmark)

    Petersen, Nils Holger

    2010-01-01

    En diskussion af Karl Barths teologiske brug af W.A.Mozart i den kirchliche Dogmatik med kontekstuel inddragelse af en til en vis grad tilsvarende overordnet diskussion af Mozart, skrevet af en samtidig musiker, den fremtrædende Mozart-dirigent Ferenc Fricsay. ......En diskussion af Karl Barths teologiske brug af W.A.Mozart i den kirchliche Dogmatik med kontekstuel inddragelse af en til en vis grad tilsvarende overordnet diskussion af Mozart, skrevet af en samtidig musiker, den fremtrædende Mozart-dirigent Ferenc Fricsay. ...

  19. Critical Limb Ischemia in Association with Charcot Neuroarthropathy: Complex Endovascular Therapy for Limb Salvage

    International Nuclear Information System (INIS)

    Palena, Luis Mariano; Brocco, Enrico; Manzi, Marco

    2014-01-01

    Charcot neuroarthropathy is a low-incidence complication of diabetic foot and is associated with ankle and hind foot deformity. Patients who have not developed deep ulcers are managed with offloading and supportive bracing or orthopedic arthrodesis. In patients who have developed ulcers and severe ankle instability and deformity, below-the-knee amputation is often indicated, especially when deformity and cutaneous involvement result in osteomyelitis. Ischemic association has not been described but can be present as a part of peripheral arterial disease in the diabetic population. In this extreme and advanced stage of combined neuroischemic diabetic foot disease, revascularization strategies can support surgical and orthopedic therapy, thus preventing osteomyelitis and leading to limb and foot salvage

  20. Jean-Martin Charcot, father of modern neurology: an homage 120 years after his death

    Directory of Open Access Journals (Sweden)

    Marleide da Mota Gomes

    2013-10-01

    Full Text Available Jean-Martin Charcot was a pioneer in a variety of subjects, including nervous system diseases; anatomy; physiology; pathology; and diseases of ageing, joints, and lungs. His medical achievements were mainly based on his anatomopathological proficiency, his observation, and his personal thoroughness that favored the delineation of the nosology of the main neurological diseases, including multiple sclerosis, amyotrophic lateral sclerosis, Parkinson’s disease, peroneal muscular atrophy, and hysteria/epilepsy. The link of this anatomoclinical method with iconographic representations and theatrical lessons, and the rich bibliographical documentations, carried out in a crowded diseased people barn - Salpetrière hospital were the basis of his achievements, which are still discussed 120 years after his death.

  1. Genetic dysfunction of MT-ATP6 causes axonal Charcot-Marie-Tooth disease.

    LENUS (Irish Health Repository)

    Pitceathly, Robert D S

    2012-09-11

    Charcot-Marie-Tooth (CMT) disease is the most common inherited neuromuscular disorder, affecting 1 in 2,500 individuals. Mitochondrial DNA (mtDNA) mutations are not generally considered within the differential diagnosis of patients with uncomplicated inherited neuropathy, despite the essential requirement of ATP for axonal function. We identified the mtDNA mutation m.9185T>C in MT-ATP6, encoding the ATP6 subunit of the mitochondrial ATP synthase (OXPHOS complex V), at homoplasmic levels in a family with mitochondrial disease in whom a severe motor axonal neuropathy was a striking feature. This led us to hypothesize that mutations in the 2 mtDNA complex V subunit encoding genes, MT-ATP6 and MT-ATP8, might be an unrecognized cause of isolated axonal CMT and distal hereditary motor neuropathy (dHMN).

  2. Sympathetic neuropathy in diabetes mellitus patients does not elicit Charcot osteoarthropathy

    DEFF Research Database (Denmark)

    Christensen, Tomas M; Simonsen, Lene; Holstein, Per E

    2011-01-01

    AIM: The aim of the study was to determine the degree of neuropathy (autonomic and somatic) in patients with diabetes mellitus with or without Charcot osteoarthropathy (CA). METHODS: Forty-nine patients with diabetes mellitus type 1 or 2 were investigated. The patient population of interest...... with first toe amputation (n=5), a high-risk group for development of CA, and two control groups consisting of diabetes patients with (n=9) or without somatic neuropathy (n=11) were investigated. Regional blood flow in the feet was measured by venous occlusion plethysmography. Quantitation of somatic...... neuropathy was done by the Neuropathy Disability Score and modified Neuropathy Symptom Score. Quantitation of autonomic neuropathy was done by measurements of local venoarteriolar sympathetic axon reflex in the feet and of heart rate variability during deep breathing and orthostatic challenge. RESULTS...

  3. Hereditaer motorisk sensorisk neuropati (Charcot-Marie-Tooths sygdom). Molekyloergenetiske aspekter

    DEFF Research Database (Denmark)

    Hertz, M J; Børglum, Anders; Brandt, C A

    1995-01-01

    Hereditary motor and sensory neuropathy (HMSN) comprises a heterogenous group of peripheral neuropathies which are classified on the basis of symptoms, mode of inheritance and electrophysiological and neuropathological investigations. HMSN type I, or Charcot-Marie-Tooth disease (CMT) type 1...... be detected by DNA-analysis. The genes for HMSN type Ia, Ib and an X-linked dominant form have been identified as PMP22, MPZ and GJB1 respectively. Analysis for these molecular defects will become important in the differential diagnosis of peripheral neuropathies and will surely prove invaluable......, is a hypertrophic and demyelinating neuropathy with reduced nerve conduction velocity, and most often with dominant inheritance. HMSN type II (CMT type 2), the neuronal or axonal form, is dominantly inherited with normal or only moderately reduced nerve conduction velocity. HMSN type III, also called Déjérine...

  4. Diagnóstico clínico de la enfermedad Charcot-Marie-Tooth

    Directory of Open Access Journals (Sweden)

    Yuselis Pérez Cid

    2014-08-01

    Full Text Available La enfermedad de Charcot-Marie-Tooth es un trastorno polineuropático genéticamente heterogéneo, en la que se han identificado más de 30 genes responsables; sin embargo, el diagnóstico es posible establecerlo sobre las bases de los estudios clínicos y electrofisiológicos. Constituye un reto en la práctica médica de los países del tercer mundo contar con la realización sistemática de estudios genéticos moleculares de las neuropatías hereditarias, por lo que en este trabajo se enfatiza en los estudios clínico-electrofisiológicos para la clasificación de la CMT

  5. Critical Limb Ischemia in Association with Charcot Neuroarthropathy: Complex Endovascular Therapy for Limb Salvage

    Energy Technology Data Exchange (ETDEWEB)

    Palena, Luis Mariano, E-mail: marianopalena@hotmail.com [Policlinico Abano Terme, Interventional Radiology Unit (Italy); Brocco, Enrico [Policlinico Abano Terme, Diabetic Foot Department, Foot and Ankle Clinic (Italy); Manzi, Marco [Policlinico Abano Terme, Interventional Radiology Unit (Italy)

    2013-05-09

    Charcot neuroarthropathy is a low-incidence complication of diabetic foot and is associated with ankle and hind foot deformity. Patients who have not developed deep ulcers are managed with offloading and supportive bracing or orthopedic arthrodesis. In patients who have developed ulcers and severe ankle instability and deformity, below-the-knee amputation is often indicated, especially when deformity and cutaneous involvement result in osteomyelitis. Ischemic association has not been described but can be present as a part of peripheral arterial disease in the diabetic population. In this extreme and advanced stage of combined neuroischemic diabetic foot disease, revascularization strategies can support surgical and orthopedic therapy, thus preventing osteomyelitis and leading to limb and foot salvage.

  6. [Genetic study of the autosomal recessive form of Charcot-Marie-Tooth in an Algerian family].

    Science.gov (United States)

    Hamadouche, T; Tazir-Melboucy, M; Benhassine, T

    1998-01-01

    Charcot-Marie-Tooth disease (CMT) is a hereditary neuropathy characterized by muscular atrophy and progressive sensitive alterations that affect limbs. The CMT is one of the most heterogenous diseases, clinically as well as genetically. At least twelve loci are responsible for the CMT phenotype, four of them for the autosomal recessive form. The aim of our work was to determinate the implication/exclusion of these four loci in an Algerian family by linkage analysis using microsatellites markers. We have tested the four loci on 8q13-21.1 (CMT4A), 11q23 (CMT4B), 5q23-33 (CMT4C) 8q24 (CMTAR). The haplotype reconstruction allowed us to exclude all the loci in this family, suggesting that the locus (gene) responsible for this form of CMT is localized elsewhere in the genome, thus providing an other observation of the great heterogeneity of the CMT, particularly autosomal recessive.

  7. Differentially expressed circulating microRNAs in the development of acute diabetic Charcot foot.

    Science.gov (United States)

    Pasquier, Jennifer; Ramachandran, Vimal; Abu-Qaoud, Moh'd Rasheed; Thomas, Binitha; Benurwar, Manasi J; Chidiac, Omar; Hoarau-Véchot, Jessica; Robay, Amal; Fakhro, Khalid; Menzies, Robert A; Jayyousi, Amin; Zirie, Mahmoud; Al Suwaidi, Jassim; Malik, Rayaz A; Talal, Talal K; Najafi-Shoushtari, Seyed Hani; Rafii, Arash; Abi Khalil, Charbel

    2018-06-05

    Charcot foot (CF) is a rare complication of Type 2 diabetes (T2D). We assessed circulating miRNAs in 17 patients with T2D and acute CF (G1), 17 patients with T2D (G2) and equivalent neuropathy and 17 patients with T2D without neuropathy (G3) using the high-throughput miRNA expression profiling. 51 significantly deregulated miRNAs were identified in G1 versus G2, 37 in G1 versus G3 and 64 in G2 versus G3. Furthermore, we demonstrated that 16 miRNAs differentially expressed between G1 versus G2 could be involved in osteoclastic differentiation. Among them, eight are key factors involved in CF pathophysiology. Our data reveal that CF patients exhibit an altered expression profile of circulating miRNAs.

  8. Central motor and sensory pathway involvement in an X-linked Charcot-Marie-Tooth family.

    Science.gov (United States)

    Zambelis, T; Panas, M; Kokotis, P; Karadima, G; Kararizou, E; Karandreas, N

    2008-06-01

    The aim of the present study was to investigate the subclinical involvement of the central nervous system (CNS) in an X-linked Charcot-Marie-Toth (CMTX) family. Seven subjects, all members of one family with a C.462T > G connexin 32 (Cx32) mutation were investigated by Blink reflex, Somatosensory evoked potentials (SEP) and Transcranial magnetic stimulation (TMS). There were five clinically symptomatic for CMT neuropathy (four male and one female) and two asymptomatic (female) subjects. Subclinical CNS involvement was observed in all, symptomatic and asymptomatic subjects. This is the largest CMTX neuropathy family investigated for CNS involvement. Electrophysiological involvement of the CNS in every examined member of this family was observed, raising the question of a more systematic involvement of the CNS in CMTX disease.

  9. Potential skin involvement in ALS: revisiting Charcot's observation - a review of skin abnormalities in ALS.

    Science.gov (United States)

    Paré, Bastien; Gros-Louis, François

    2017-07-26

    Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease affecting motor neurons of the brain and spinal cord, leading to progressive paralysis and death. Interestingly, many skin changes have been reported in ALS patients, but never as yet fully explained. These observations could be due to the common embryonic origin of the skin and neural tissue known as the ectodermal germ layer. Following the first observation in ALS patients' skin by Dr Charcot in the 19th century, in the absence of bedsores unlike other bedridden patients, other morphological and molecular changes have been observed. Thus, the skin could be of interest in the study of ALS and other neurodegenerative diseases. This review summarizes skin changes reported in the literature over the years and discusses about a novel in vitro ALS tissue-engineered skin model, derived from patients, for the study of ALS.

  10. Diabetisk nefropati. Uaendret forekomst hos patienter med insulinkraevende diabetes mellitus

    DEFF Research Database (Denmark)

    Rossing, P; Rossing, K; Jacobsen, P

    1996-01-01

    Recently, a dramatic decline in the cumulative incidence of diabetic nephropathy (less than 10% after 25 years of diabetes) has been reported in IDDM patients diagnosed between 1961 and 1980. In a clinic based study we assessed recent trends in the incidence of diabetic nephropathy. All 356...... patients in whom IDDM was diagnosed before the age of 41 years between 1965 and 1979, identified in 1984 were followed to 1991 or to death. The cumulative incidence of diabetic nephropathy (urinary albumin excretion 300 mg/24 hours in two out of three consecutive samples) after 15 years of diabetes...... and in 1991 were (cumulative incidence (SE)): 18 (4)% and 35 (5)% (onset of diabetes 1965-69, n = 113), 20 (4)% and 35 (5)% (onset of diabetes 1970-74, n = 130), and 16 (5)% (onset of diabetes 1975-79, n = 113), respectively (ns). The mean (SE) haemoglobin A1c measured yearly beginning in 1984 was higher...

  11. Digital kommunikation med den offentlige sektor

    DEFF Research Database (Denmark)

    Berger, Jesper Bull; Andersen, Kim Normann

    til. I denne undersøgelse sættes der fokus på myndighedernes besvarelse af den digitale post. Digital post blev bl.a. etableret som et alternativ til almindelig e-mail for at det offentlige kan kommunikere med borgere og virksomheder på en sikker måde, dvs. uden at uvedkommende kan få adgang til...... følsomme oplysninger. Fokus for undersøgelsen er hvordan håndterer myndighederne besvarelserne i den digitale postkasse: svarer de på digital post og e-mail, hvor hurtigt svarer de og er svarene brugbare? Undersøgelsen medtager myndighedernes besvarelse af digital post og e-mail, dels for at kunne...... sammenligne de to digitale kanaler og for at kunne sammenligne med en tidligere undersøgelse af digital kommunikation med det offentlige. Herudover er der tidligere gennemført en undersøgelse af e-mail svar og svartider i New Zealand og Australien. De danske resultater fra e-mail undersøgelsen, men ikke...

  12. Artropatia de charcot do mediopé no paciente diabético: complicação de uma doença epidêmica Mid-foot charcot arthropathy in diabetic patients: complication of an epidemic disease

    Directory of Open Access Journals (Sweden)

    Ricardo Cardenuto Ferreira

    2012-10-01

    Full Text Available OBJETIVOS: Traçar o perfil epidemiológico dos pacientes diabéticos portadores de artropatia de Charcot acometendo exclusivamente o mediopé ou estendendo-se do mediopé ao retropé. Avaliar, a médio prazo, o resultado do tratamento a que esses pacientes são submetidos seguindo um protocolo preestabelecido. MÉTODOS: Avaliamos, retrospectivamente, 88 pacientes (110 extremidades portadores de artropatia de Charcot do mediopé, com seguimento mínimo de 12 meses. Incluímos os pacientes portadores de artropatia de Charcot acometendo as articulações tarsometatársicas, 45 pacientes (51%; as articulações talonavicular, calcaneocuboide e subtalar, 20 pacientes (23%; e aqueles com envolvimento do mediopé e retropé, 23 pacientes (26%, segundo Brodsky e Trepman. Definimos como sucesso a preservação de um pé funcional e insucesso como amputação do pé. RESULTADOS: O tratamento da artropatia de Charcot envolvendo primariamente o mediopé foram satisfatórios em 75 pacientes (85% tratados seguindo nosso protocolo. Nos pacientes com lesões graves, acometendo tanto o mediopé quanto o retropé, foi necessário maior número de cirurgias complexas do tipo artrodese para se obter o mesmo índice global de resultados satisfatórios. A lesão osteoarticular originada no mediopé provavelmente estende-se progressivamente ao retropé devido à demora no diagnóstico no início do tratamento adequado. CONCLUSÃO: Foi possível preservar uma extremidade funcional em 85% dos pacientes. Lesões graves envolvendo o mediopé e estendendo-se ao retropé necessitaram maior número de cirurgias para o tratamento.OBJECTIVES: To outline the epidemiological profile of diabetic patients with Charcot arthropathy affecting the midfoot alone or extending from the midfoot to the hindfoot; To assess the results from the treatment that these patients undergo, according to a preestablished protocol, over the medium term. METHODS: We retrospectively evaluated 88

  13. A neurological bias in the history of hysteria: from the womb to the nervous system and Charcot

    Directory of Open Access Journals (Sweden)

    Marleide da Mota Gomes

    2014-12-01

    Full Text Available Hysteria conceptions, from ancient Egypt until the 19th century Parisian hospital based studies, are presented from gynaecological and demonological theories to neurological ones. The hysteria protean behavioral disorders based on nervous origin was proposed at the beginning, mainly in Great Britain, by the “enlightenment nerve doctors”. The following personages are highlighted: Galen, William, Sydenham, Cullen, Briquet, and Charcot with his School. Charcot who had hysteria and hypnotism probably as his most important long term work, developed his conceptions, initially, based on the same methodology he applied to studies of other neurological disorder. Some of his associates followed him in his hysteria theories, mainly Paul Richer and Gilles de La Tourette who produced, with the master's support, expressive books on Salpêtrière School view on hysteria.

  14. A neurological bias in the history of hysteria: from the womb to the nervous system and Charcot.

    Science.gov (United States)

    Mota Gomes, Marleide da; Engelhardt, Eliasz

    2014-12-01

    Hysteria conceptions, from ancient Egypt until the 19th century Parisian hospital based studies, are presented from gynaecological and demonological theories to neurological ones. The hysteria protean behavioral disorders based on nervous origin was proposed at the beginning, mainly in Great Britain, by the "enlightenment nerve doctors". The following personages are highlighted: Galen, William, Sydenham, Cullen, Briquet, and Charcot with his School. Charcot who had hysteria and hypnotism probably as his most important long term work, developed his conceptions, initially, based on the same methodology he applied to studies of other neurological disorder. Some of his associates followed him in his hysteria theories, mainly Paul Richer and Gilles de La Tourette who produced, with the master's support, expressive books on Salpêtrière School view on hysteria.

  15. Charcot-Marie-Tooth disease-linked protein SIMPLE functions with the ESCRT machinery in endosomal trafficking

    OpenAIRE

    Lee, Samuel M.; Chin, Lih-Shen; Li, Lian

    2012-01-01

    Mutations in small integral membrane protein of lysosome/late endosome (SIMPLE) cause autosomal dominant, Charcot-Marie-Tooth disease (CMT) type 1C. The cellular function of SIMPLE is unknown and the pathogenic mechanism of SIMPLE mutations remains elusive. Here, we report that SIMPLE interacted and colocalized with endosomal sorting complex required for transport (ESCRT) components STAM1, Hrs, and TSG101 on early endosomes and functioned with the ESCRT machinery in the control of endosome-to...

  16. Charcot Foot

    Science.gov (United States)

    ... damage (neuropathy). The bones are weakened enough to fracture, and with continued walking, the foot eventually changes ... difference. Advanced therapies for foot wounds are saving limbs, restoring ... in the feet come from the lower back. Pressure or chemical change in the nerve ...

  17. Trump, NATO og den europæiske sikkerhedsarkitektur

    DEFF Research Database (Denmark)

    Ringsmose, Jens; Henriksen, Anders

    Manglende klarhed i den amerikanske linje over for det NATO, landet indtil nu har taget føringen i, vil få konsekvenser for Europa og for Danmarks muligheder og valg. Denne rapport ser på konsekvenserne for den europæiske sikkerhedsarkitektur....

  18. Vildsvin uønsket i den danske natur

    DEFF Research Database (Denmark)

    Andersen, Camilla Brasch; Bald, Caroline; Uttenthal, Åse

    2011-01-01

    Vildsvin ønskes fortsat ikke etableret i den danske natur, da de udgør en smitterisiko for husdyr og mennesker. det er helt essentielt for bekæmpelsen, at lodsejere og jægere deltager aktivt. de skal lokalisere de vildsvin, der allerede findes i den danske natur, og nedlægge dem....

  19. Philipp van den Bossche – Sac. Caes. Mai. Phrygiarius

    Czech Academy of Sciences Publication Activity Database

    Bukovinská, Beket

    -, č. 0130 (2015), s. 1-18 ISSN 2190-3328 Institutional support: RVO:68378033 Keywords : Philipp van den Bossche * Prague court * Rudolph II * Kunstkammer Subject RIV: AL - Art, Architecture, Cultural Heritage http://www.riha-journal.org/articles/2015/2015-oct-dec/bukovinska-philipp-van-den-bossche

  20. Empirisme, rationalisme og den moralske følelse

    DEFF Research Database (Denmark)

    Nielsen, Carsten Fogh

    2003-01-01

    Sammenlignende diskussion af David Humes og Immanuel Kants syn på følelsernes rolle for den moralske dom......Sammenlignende diskussion af David Humes og Immanuel Kants syn på følelsernes rolle for den moralske dom...

  1. Laika – den første hund i rummet

    DEFF Research Database (Denmark)

    Alstrup, Aage Kristian Olsen

    2013-01-01

    DETTE ER DEN FØRSTE ARTIKEL I EN SERIE OM FORSØGSDYRENES ROLLE I RUMFORSKNINGEN. DYRENE SPILLEDE EN CENTRAL ROLLE I RUSSERNES OG AMERIKANERNES RUMKAPLØB UNDER DEN KOLDE KRIG. I DAG BRUGES DYRENE TIL MEDICINSKE FORSØG UDFØRT I VÆGTLØS TILSTAND. FØRSTE ARTIKEL HANDLER OM GADEKRYDSET LAIKA, SOM BLEV...

  2. Synteserapport & 1. Indenrigspolitiske forhold i Den Islamiske Republik Iran

    DEFF Research Database (Denmark)

    Pedersen, Claus Valling

    Rapport til Udenrigsministeriet om de indenrigspolitiske forhold i Iran samt et syntese af hele rapporten: Iran som regional og international medspiller i den globale verdensorden samt Irans indenrigspolitik......Rapport til Udenrigsministeriet om de indenrigspolitiske forhold i Iran samt et syntese af hele rapporten: Iran som regional og international medspiller i den globale verdensorden samt Irans indenrigspolitik...

  3. Forårets konflikter godt for den danske model

    DEFF Research Database (Denmark)

    Scheuer, Steen

    2008-01-01

    Den store vinder ved forårets konflikter var den danske model for aftaler på arbejdsmarkedet. De offentlige fagforeninger fik sig en lærestreg, da regeringen og Folketinget til de flestes overraskelse lod de lovlige konflikter løbe i ugevis. For hermed tvang man parterne, og især forbundene, til...

  4. "Den lille havfrue" som digital pop op-bog

    DEFF Research Database (Denmark)

    Mygind, Sarah

    2017-01-01

    Anmeldelse af: DIGITAL POP OP-BOG H. C. ANDERSEN OG BOOKS & MAGIC DEN LILLE HAVFRUE Bog og App til iOS & Android 5......Anmeldelse af: DIGITAL POP OP-BOG H. C. ANDERSEN OG BOOKS & MAGIC DEN LILLE HAVFRUE Bog og App til iOS & Android 5...

  5. Nye militære trends i den syriske borgerkrig

    DEFF Research Database (Denmark)

    Engen, Torben Toftgaard; Kjellund, Jon

    2018-01-01

    I den flerårige syriske borgerkrig har der fundet tre nye militære trends sted, der peger imod, at fremtidens landmilitære kampplads vil være væsensforskellig fra indsatserne i Irak og Afghanistan. Denne rapport analyserer de tre trends inden for digitaliseringen af den hybride krigsførelse og ka...

  6. Samarbejdets betydning i den ’klassiske udlicitering’

    DEFF Research Database (Denmark)

    Lindholst, Andrej Christian

    2015-01-01

    Hvilken betydning har ’samarbejde’ i kontraktstyringen mellem offentlige myndigheder og private entreprenører inden for de ’klassiske’ udbudsområder? I både den administrative praksis og den politologiske litteratur betragtes en effektiv anvendelse af udlicitering på de klassiske udbudsområder of...

  7. Marguerite Bottard (1822-1906), nurse under Jean-Martin Charcot, portrayed by G. Gilles de la Tourette.

    Science.gov (United States)

    Walusinski, Olivier

    2011-01-01

    Hospitals in Paris underwent considerable change at the end of the 19th century. As they moved from providing accommodation to care, their mission shifted from helping to healing. The glorification of scientific progress, as opposed to religious obscurantism, affected all of French 'Republican' society, in particular a significant part of the medical profession, led by figures such as D.M. Bourneville, former interne (house officer) under J.M. Charcot and also his publisher. Bourneville helped bring about the creation of nursing schools and the gradual replacement of religious orders by educated secular nurses. Marguerite Bottard, Charcot's chief nurse made famous by A. Brouillet's painting 'Une leçon clinique à La Salpêtrière', would be glorified and decorated as a model for this movement. A letter by G. Gilles de la Tourette to Charcot's successor F. Raymond, never before published, illustrates this progressive current of thought and revisits the struggle to secularise hospitals under the Third Republic in France. At the same time, it renews interest in the exemplary career of a nurse whose name was recently given to a building at La Salpêtrière Hospital. Copyright © 2011 S. Karger AG, Basel.

  8. Follow up of MRI bone marrow edema in the treated diabetic Charcot foot – a review of patient charts

    Science.gov (United States)

    Chantelau, Ernst-A.; Zweck, Brigitte; Haage, Patrick

    2018-01-01

    ABSTRACT Background: Ill-defined areas of water-like signal on bone magnetic resonance imaging (MRI), characterized as bone marrow edema or edema-equivalent signal-changes (EESC), is a hallmark of active-stage pedal neuro-osteoarthropathy (Charcot foot) in painless diabetic neuropathy, and is accompanied by local soft-tissue edema and hyperthermia. The longitudinal effects on EESC of treating the foot in a walking cast were elucidated by reviewing consecutive cases of a diabetic foot clinic. Study design: Retrospective observational study, chart review Material and methods: Cases with active-stage Charcot foot were considered, in whom written reports on baseline and follow-up MRI studies were available for assessment. Only cases without concomitant infection or skin ulcer were chosen, in whom both was documented, onset of symptomatic foot swelling and patient compliance with cast treatment. Results: From 1994 to 2017, 45 consecutive cases in 37 patients were retrieved, with 95 MRI follow-up studies (1–6 per case, average interval between studies 13 weeks). Decreasing EESC was documented in 66/95 (69%) follow-up studies. However, 29/95 (31%) studies revealed temporarily increasing, migrating or stagnating EESC. Conclusion: EESC on MRI disappear in response to prolonged offloading and immobilizing treatment; however, physiologic as well as pathologic fluctuations of posttraumatic EESC have to be considered when interpreting the MR images. Conventional MRI is useful for surveillance of active-stage Charcot foot recovery. PMID:29713425

  9. [Identification of Dens Draconis and Os Draconis by XRD method].

    Science.gov (United States)

    Chen, Guang-Yun; Wu, Qi-Nan; Shen, Bei; Chen, Rong

    2012-04-01

    To establish an XRD method for evaluating the quality of Os Draconis and Dens Draconis and applying in judgement of the counterfeit. Dens Draconis, Os Draconis and the counterfeit of Os Draconis were analyzed by XRD. Their diffraction patterns were clustered analysis and evaluated their similarity degree. Established the analytical method of Dens Draconis and Os Draconis basing the features fingerprint information of the 10 common peaks by XRD pattern. Obtained the XRD pattern of the counterfeit of Os Draconis. The similarity degree of separate sources of Dens Draconis was high,while the similarity degree of separate sources of Os Draconis was significant different from each other. This method can be used for identification and evaluation of Os Draconis and Dens Draconis. It also can be used for identification the counterfeit of Os Draconis effectively.

  10. Kosmetisk kirurgi og den transformérbare krop -en analyse af den amerikanske tv-serie Nip/Tuck

    DEFF Research Database (Denmark)

    Jerslev, Anne

    2009-01-01

    En analyse af krops- og kønsiscenesættelser i den amerikanske tv-serie om kosmetisk kirurgi Nip/Tuck......En analyse af krops- og kønsiscenesættelser i den amerikanske tv-serie om kosmetisk kirurgi Nip/Tuck...

  11. Endodontic, surgical and periodontal treatment of dens invaginatus. Case report.

    Science.gov (United States)

    Castellarin, M; Demitri, V; Politi, M

    2001-01-01

    The aim of this paper is to propose a single stage global treatment of endodontic, periapical and periodontal lesions in a lateral maxillary incisor with dens invaginatus. A 24 year-old woman presenting a lateral maxillary incisor with dens invaginatus in association with periapica1 and periodontal lesions underwent simultaneous surgical, endodontic and periodontal regenerative procedures. At 2, 6, 12, 18 months follow-up the radiographic healing appeared to be improved and the periapical lesion healed completely 1 year after surgical intervention. Surgery in association with endodontic and periodontal procedures represents the treatment of choice to maximize long term prognosis in cases of dens invaginatus with chronic periapical and periodontal lesions.

  12. Injury biomechanics of C2 dens fractures.

    Science.gov (United States)

    Yoganandan, Narayan; Pintar, Frank; Baisden, Jamie; Gennarelli, Thomas; Maiman, Dennis

    2004-01-01

    The objective of this study is to analyze the biomechanics of dens fractures of the second cervical vertebra in the adult population due to motor vehicle crashes. Case-by-case records from the Crash Injury Research and Engineering Network (CIREN) and National Automotive Sampling System (NASS) databases were used. Variables such as change in velocity, impact direction and body habitus were extracted. Results indicated that similarities exist in the two databases despite differences in sampling methods between the two sources (e.g., CIREN is not population based). Trauma is predominantly associated with the frontal mode of impact. Majority of injuries occur with change in velocities below current federal guideline thresholds. No specific bias exists with respect to variables such as age, height, weight, and gender. Because similar conclusions can be drawn with regard to vehicle model years, design changes during these years may have had little effect on this injury. To ameliorate trauma, emphasis should be placed on the frontal impact mode and entire adult population. Because of clinical implications in the fracture type (II being most critical) and lack of specific coding, CIREN data demonstrates the need to improve injury coding in the AIS and application in the NASS to enhance occupant safety and treatment in the field of automotive medicine.

  13. Hereditary motor and sensory neuropathies or Charcot-Marie-Tooth diseases: an update.

    Science.gov (United States)

    Tazir, Meriem; Hamadouche, Tarik; Nouioua, Sonia; Mathis, Stephane; Vallat, Jean-Michel

    2014-12-15

    Hereditary motor and sensory neuropathies (HMSN) or Charcot-Marie-Tooth (CMT) diseases are the most common degenerative disorders of the peripheral nervous system. However, the frequency of the different subtypes varies within distinct populations. Although more than seventy clinical and genetic forms are known to date, more than 80% of CMT patients in Western countries have genetic abnormalities associated with PMP22, MPZ, MFN2 and GJB1. Given the considerable genetic heterogeneity of CMT, we emphasize the interest of both clinical and pathological specific features such that focused genetic testing could be performed. In this regard, peripheral nerve lesions in GDAP1 mutations (AR CMT1A), such as mitochondrial abnormalities, have been newly demonstrated. Otherwise, while demyelinating autosomal recessive CMT used to be classified as CMT4 (A, B, C …), we propose a simplified classification such as AR CMT1 (A, B, C …), and AR CMT2 for axonal forms. Also, we stress that next generation sequencing techniques, now considered to be the most efficient methods of genetic testing in CMT, will be helpful in molecular diagnosis and research of new genes involved. Finally, while no effective therapy is known to date, ongoing new therapeutic trials such as PXT3003 (a low dose combination of the three already approved drugs baclofen, naltrexone, and D-sorbitol) give hopes for potential curative treatment. Copyright © 2014 Elsevier B.V. All rights reserved.

  14. Charcot Marie Tooth 2B Peripheral Sensory Neuropathy: How Rab7 Mutations Impact NGF Signaling?

    Directory of Open Access Journals (Sweden)

    Harry Liu

    2017-02-01

    Full Text Available Charcot-Marie-Tooth 2B peripheral sensory neuropathy (CMT2B is a debilitating autosomal dominant hereditary sensory neuropathy. Patients with this disease lose pain sensation and frequently need amputation. Axonal dysfunction and degeneration of peripheral sensory neurons is a major clinical manifestation of CMT2B. However, the cellular and molecular pathogenic mechanisms remain undefined. CMT2B is caused by missense point mutations (L129F, K157N, N161T/I, V162M in Rab7 GTPase. Strong evidence suggests that the Rab7 mutation(s enhances the cellular levels of activated Rab7 proteins, thus resulting in increased lysosomal activity and autophagy. As a consequence, trafficking and signaling of neurotrophic factors such as nerve growth factor (NGF in the long axons of peripheral sensory neurons are particularly vulnerable to premature degradation. A “gain of toxicity” model has, thus, been proposed based on these observations. However, studies of fly photo-sensory neurons indicate that the Rab7 mutation(s causes a “loss of function”, resulting in haploinsufficiency. In the review, we summarize experimental evidence for both hypotheses. We argue that better models (rodent animals and human neurons of CMT2B are needed to precisely define the disease mechanisms.

  15. Charcot Marie Tooth 2B Peripheral Sensory Neuropathy: How Rab7 Mutations Impact NGF Signaling?

    Science.gov (United States)

    Liu, Harry; Wu, Chengbiao

    2017-02-04

    Charcot-Marie-Tooth 2B peripheral sensory neuropathy (CMT2B) is a debilitating autosomal dominant hereditary sensory neuropathy. Patients with this disease lose pain sensation and frequently need amputation. Axonal dysfunction and degeneration of peripheral sensory neurons is a major clinical manifestation of CMT2B. However, the cellular and molecular pathogenic mechanisms remain undefined. CMT2B is caused by missense point mutations (L129F, K157N, N161T/I, V162M) in Rab7 GTPase. Strong evidence suggests that the Rab7 mutation(s) enhances the cellular levels of activated Rab7 proteins, thus resulting in increased lysosomal activity and autophagy. As a consequence, trafficking and signaling of neurotrophic factors such as nerve growth factor (NGF) in the long axons of peripheral sensory neurons are particularly vulnerable to premature degradation. A "gain of toxicity" model has, thus, been proposed based on these observations. However, studies of fly photo-sensory neurons indicate that the Rab7 mutation(s) causes a "loss of function", resulting in haploinsufficiency. In the review, we summarize experimental evidence for both hypotheses. We argue that better models (rodent animals and human neurons) of CMT2B are needed to precisely define the disease mechanisms.

  16. Oral Health, Temporomandibular Disorder, and Masticatory Performance in Patients with Charcot-Marie-Tooth Type 2

    Directory of Open Access Journals (Sweden)

    Rejane L. S. Rezende

    2013-01-01

    Full Text Available Background. The aim of this study was to evaluate the oral health status of temporomandibular disorders (TMD and bruxism, as well as to measure masticatory performance of subjects with Charcot-Marie-Tooth type 2 (CMT2. Methods and Results. The average number of decayed, missing, and filled teeth (DMFT for both groups, control (CG and CMT2, was considered low (CG = 2.46; CMT2 = 1.85, P=0.227. The OHIP-14 score was considered low (CG = 2.86, CMT2 = 5.83, P=0.899. The prevalence of self-reported TMD was 33.3% and 38.9% (P=0.718 in CG and CMT2 respectively and for self-reported bruxism was 4.8% (CG and 22.2% (CMT2, without significant difference between groups (P=0.162. The most common clinical sign of TMD was masseter (CG = 38.1%; CMT2 = 66.7% and temporalis (CG = 19.0%; GCMT2 = 33.3% muscle pain. The geometric mean diameter (GMD was not significantly different between groups (CG = 4369; CMT2 = 4627, P=0.157. Conclusion. We conclude that the CMT2 disease did not negatively have influence either on oral health status in the presence and severity of TMD and bruxism or on masticatory performance.

  17. Intermittent fasting alleviates the neuropathic phenotype in a mouse model of Charcot-Marie-Tooth disease

    Science.gov (United States)

    Madorsky, Irina; Opalach, Katherine; Waber, Amanda; Verrier, Jonathan D.; Solmo, Chelsea; Foster, Thomas; Dunn, William A; Notterpek, Lucia

    2009-01-01

    Charcot-Marie-Tooth type 1A (CMT1A) neuropathies linked to the misexpression of peripheral myelin protein 22 (PMP22) are progressive demyelinating disorders of the peripheral nervous system. In this study we asked whether dietary restriction by intermittent fasting (IF) could alleviate the neuropathic phenotype in the Trembler J (TrJ) mouse model of CMT1A. Our results show that neuropathic mice kept on a five month long IF regimen had improved locomotor performance compared to ad libitum (AL) fed littermates. The functional benefits of this dietary intervention are associated with an increased expression of myelin proteins combined with a thicker myelin sheath, less redundant basal lamina, and a reduction in aberrant Schwann cell proliferation. These morphological improvements are accompanied by a decrease in PMP22 protein aggregates, and enhanced expression of cytosolic chaperones and constituents of the autophagy-lysosomal pathway. These results indicate that dietary restriction is beneficial for peripheral nerve function in TrJ neuropathic mice, as it promotes the maintenance of locomotor performance. PMID:19320048

  18. Neural and Molecular Features on Charcot-Marie-Tooth Disease Plasticity and Therapy

    Directory of Open Access Journals (Sweden)

    Paula Juárez

    2012-01-01

    Full Text Available In the peripheral nervous system disorders plasticity is related to changes on the axon and Schwann cell biology, and the synaptic formations and connections, which could be also a focus for therapeutic research. Charcot-Marie-Tooth disease (CMT represents a large group of inherited peripheral neuropathies that involve mainly both motor and sensory nerves and induce muscular atrophy and weakness. Genetic analysis has identified several pathways and molecular mechanisms involving myelin structure and proper nerve myelination, transcriptional regulation, protein turnover, vesicle trafficking, axonal transport and mitochondrial dynamics. These pathogenic mechanisms affect the continuous signaling and dialogue between the Schwann cell and the axon, having as final result the loss of myelin and nerve maintenance; however, some late onset axonal CMT neuropathies are a consequence of Schwann cell specific changes not affecting myelin. Comprehension of molecular pathways involved in Schwann cell-axonal interactions is likely not only to increase the understanding of nerve biology but also to identify the molecular targets and cell pathways to design novel therapeutic approaches for inherited neuropathies but also for most common peripheral neuropathies. These approaches should improve the plasticity of the synaptic connections at the neuromuscular junction and regenerate cell viability based on improving myelin and axon interaction.

  19. Resetting translational homeostasis restores myelination in Charcot-Marie-Tooth disease type 1B mice.

    Science.gov (United States)

    D'Antonio, Maurizio; Musner, Nicolò; Scapin, Cristina; Ungaro, Daniela; Del Carro, Ubaldo; Ron, David; Feltri, M Laura; Wrabetz, Lawrence

    2013-04-08

    P0 glycoprotein is an abundant product of terminal differentiation in myelinating Schwann cells. The mutant P0S63del causes Charcot-Marie-Tooth 1B neuropathy in humans, and a very similar demyelinating neuropathy in transgenic mice. P0S63del is retained in the endoplasmic reticulum of Schwann cells, where it promotes unfolded protein stress and elicits an unfolded protein response (UPR) associated with translational attenuation. Ablation of Chop, a UPR mediator, from S63del mice completely rescues their motor deficit and reduces active demyelination by half. Here, we show that Gadd34 is a detrimental effector of CHOP that reactivates translation too aggressively in myelinating Schwann cells. Genetic or pharmacological limitation of Gadd34 function moderates translational reactivation, improves myelination in S63del nerves, and reduces accumulation of P0S63del in the ER. Resetting translational homeostasis may provide a therapeutic strategy in tissues impaired by misfolded proteins that are synthesized during terminal differentiation.

  20. X inactivation in females with X-linked Charcot-Marie-Tooth disease.

    LENUS (Irish Health Repository)

    Murphy, Sinéad M

    2012-07-01

    X-linked Charcot-Marie-Tooth disease (CMT1X) is the second most common inherited neuropathy, caused by mutations in gap junction beta-1 (GJB1). Males have a uniformly moderately severe phenotype while females have a variable phenotype, suggested to be due to X inactivation. We aimed to assess X inactivation pattern in females with CMT1X and correlate this with phenotype using the CMT examination score to determine whether the X inactivation pattern accounted for the variable phenotype in females with CMT1X. We determined X inactivation pattern in 67 females with CMT1X and 24 controls using the androgen receptor assay. We were able to determine which X chromosome carried the GJB1 mutation in 30 females. There was no difference in X inactivation pattern between patients and controls. In addition, there was no correlation between X inactivation pattern in blood and phenotype. A possible explanation for these findings is that the X inactivation pattern in Schwann cells rather than in blood may explain the variable phenotype in females with CMT1X.

  1. Intermittent fasting alleviates the neuropathic phenotype in a mouse model of Charcot-Marie-Tooth disease.

    Science.gov (United States)

    Madorsky, Irina; Opalach, Katherine; Waber, Amanda; Verrier, Jonathan D; Solmo, Chelsea; Foster, Thomas; Dunn, William A; Notterpek, Lucia

    2009-04-01

    Charcot-Marie-Tooth type 1A (CMT1A) neuropathies linked to the misexpression of peripheral myelin protein 22 (PMP22) are progressive demyelinating disorders of the peripheral nervous system. In this study we asked whether dietary restriction by intermittent fasting (IF) could alleviate the neuropathic phenotype in the Trembler J (TrJ) mouse model of CMT1A. Our results show that neuropathic mice kept on a five month long IF regimen had improved locomotor performance compared to ad libitum (AL) fed littermates. The functional benefits of this dietary intervention are associated with an increased expression of myelin proteins combined with a thicker myelin sheath, less redundant basal lamina, and a reduction in aberrant Schwann cell proliferation. These morphological improvements are accompanied by a decrease in PMP22 protein aggregates, and enhanced expression of cytosolic chaperones and constituents of the autophagy-lysosomal pathway. These results indicate that dietary restriction is beneficial for peripheral nerve function in TrJ neuropathic mice, as it promotes the maintenance of locomotor performance.

  2. Exercise training improves autonomic profiles in patients with Charcot-Marie-Tooth disease.

    Science.gov (United States)

    El Mhandi, Lhassan; Pichot, Vincent; Calmels, Paul; Gautheron, Vincent; Roche, Frédéric; Féasson, Léonard

    2011-11-01

    The effect of an interval exercise training (ITE) program on heart rate variability (HRV) was studied in 8 patients with Charcot-Marie-Tooth (CMT) disease and 8 healthy controls. At baseline, all subjects underwent ambulatory 24-hour Holter electrocardiographic (ECG) monitoring to evaluate HRV. HRV analysis was repeated on CMT patients after they completed a 24-week ITE program on a cycle ergometer. Before exercise, all HRV indices were lower in patients compared with controls, and the difference reached statistical significance for pNN50 (percent of differences between adjacent R-R intervals exceeding 50 ms). After ITE, time- and frequency-domain indices were significantly improved, particularly at night (+8% mean R-R interval, +95% pNN50, 52% reduction in low/high-frequency ratio). We observed significant increases in some of the time and frequency parameters, and values sometimes exceeded those of controls at baseline. Our results suggest that ITE improves HRV modulation in CMT patients by enhancing parasympathetic activity. Copyright © 2011 Wiley Periodicals, Inc.

  3. Radiomontagen og dens radiofoniske rødder. Om hørebilledet, den litterære tekstmontage, featuren og den moderne radiomontage

    Directory of Open Access Journals (Sweden)

    Ib Poulsen

    2001-09-01

    Full Text Available Radiomontagen og dens genrevarianter, hørebilledet og featuren har tidligere har tidligere været genstand for interesse fra især den æste- tiske og tekstanalytisk orienterede radioforskning. I denne artikel sæt- tes genren ind i en bredere kontekst, sociokulturelt og medie- og insti- tutionshistorisk. Ledetrådene i den diakrone fremstilling er dels spørgs- målet om genrens historiske og genremæssige rødder, dels en kombi- neret tekstanalytisk og receptionsæstetisk tilgang, der søger at ind- kredse de positioneringer af lytteren, radiomontagen og dens varianter tilbyder. Artiklen er baseret på grundige arkivstudier i DR og på inter- views med nogle af de ’montører’, som har bidraget til udviklingen af montagen, der i kraft af sin radiofoniske spændvidde mest vedholdende og varieret har forsøgt at udforske menneskets livssituation i den moder- ne verden, samtidig med at lytteren er blevet tilbudt en lytteposition, der prioriterer refleksion og eftertanke.

  4. Vidensledelse og den sociale dimension i deling af viden

    DEFF Research Database (Denmark)

    Lauring, Jakob

    2004-01-01

    imidlertid et alternativt syn på viden som i højere grad inddrager den sociale dimension ved vidensdeling - den socialkonstruktivistiske opfattelse. I denne artikel vil jeg beskæftige mig med den socialkonstruktivistiske opfattelse af viden og beskrive, hvorledes denne synsvinkel kan rette fokus mod nogle...... meget væsentlige problemstillinger ved organisatorisk adfærd, som man ofte kommer til at ignorere, hvis man i for høj grad baserer ledelsen på en funktionalistisk opfattelse af viden. Delingen af viden er en aktuel udfordring for anvendelse af viden i forretningssammenhæng. Det er hovedsageligt det, som...... gør vidensbegrebet interessant i forhold til ledelse af virksomheder. - Fokus på de sociale barrierer for deling af viden Jeg vil i det kommende illustrere, hvilke betydninger den sociale dimension i deling af viden kan have for videnledelse. Det vil jeg gøre gennem beskrivelser af to forskellige...

  5. Uddrag af Ph.d.-afhandlingen Den groteske modernisme

    DEFF Research Database (Denmark)

    Lübker, Henrik

    2011-01-01

    Om forholdet mellem "det groteske" og "den groteske modernisme" eksemplificeret i en læsning af E.A. Poes "The Fall of the House of Usher" og flere af Francis Bacons malerier.......Om forholdet mellem "det groteske" og "den groteske modernisme" eksemplificeret i en læsning af E.A. Poes "The Fall of the House of Usher" og flere af Francis Bacons malerier....

  6. CIOs mangler fundamentale egenskaber for at lede den digitale transformation

    DEFF Research Database (Denmark)

    Bjørn-Andersen, Niels

    2016-01-01

    CIOs er dårligt rustet til at gå i spidsen for digital disruption og innovation, advarer den internationale topforsker Joe Peppard med afsæt i analyse af mere end 200 CIO-s personligheder......CIOs er dårligt rustet til at gå i spidsen for digital disruption og innovation, advarer den internationale topforsker Joe Peppard med afsæt i analyse af mere end 200 CIO-s personligheder...

  7. Malaysia. Kan den politiske fred fortsætte?

    DEFF Research Database (Denmark)

    Fleming, Daniel; Søborg, Henrik

    2008-01-01

    Der er valg i det muslimske Malaysia den 8. marts 2008. Et land med klar etnisk opdeling, men også med stor politisk stabilitet. Hvordan hænger det sammen?......Der er valg i det muslimske Malaysia den 8. marts 2008. Et land med klar etnisk opdeling, men også med stor politisk stabilitet. Hvordan hænger det sammen?...

  8. Den danske stat og det naturlige fædreland

    DEFF Research Database (Denmark)

    Glenthøj, Rasmus

    2007-01-01

    forsøgte på engang at være loyale over for både det statsborgerlige fædreland, der inkluderede hele den danske stat, og deres naturlige fædreland Norge, som de følte sig forbundet til gennem deres nationalitet og opvækst. Danskerne opererede med den samme dualistiske fædrelandsopfattelse, hvor de både...

  9. Den europæiske sukkersektor - efter reformerne

    DEFF Research Database (Denmark)

    Hansen, Henning Otte

    2017-01-01

    Med reformerne af EU’s sukkerpolitik ændredes vilkårene for hele den europæiske sukkersektor. Resultatet ses nu i form af stærkere struktur- og produktivitetsudvikling og dermed en stigende international konkurrenceevne.......Med reformerne af EU’s sukkerpolitik ændredes vilkårene for hele den europæiske sukkersektor. Resultatet ses nu i form af stærkere struktur- og produktivitetsudvikling og dermed en stigende international konkurrenceevne....

  10. Role of dynamic MRI in the follow-up of acute Charcot foot in patients with diabetes mellitus

    International Nuclear Information System (INIS)

    Zampa, Virna; Bargellini, Irene; Turini, Francesca; Ortori, Simona; Bartolozzi, Carlo; Rizzo, Loredana; Piaggesi, Alberto

    2011-01-01

    To evaluate the usefulness of magnetic resonance imaging (MRI) in assessing the level of activity of acute Charcot foot, monitoring treatment response and predicting healing time. Forty diabetic patients with acute Charcot foot were prospectively enrolled. Patients underwent limb immobilization and were followed every 3 months by clinical examination (skin temperature and circumferences) and MRI. MR protocol included T1-weighted and fast spin echo inversion recovery (FSE-IR) sequences, and a dynamic study (fast spoiled gradient echo), after gadolinium administration (0.1 ml/kg). The contrast medium uptake rate at D-MRI and the signal intensity (SI) ratio on the FSE-IR sequence were measured. At baseline, mean contrast medium uptake rate was 136±49.7% and the mean SI ratio was 5±3. A high intra- and inter-observer agreement was found for the contrast medium uptake rate, whereas a low agreement was observed for the SI ratio. At 3 months' follow-up, reduction of the contrast medium uptake rate was observed in all patients with improved clinical findings (n = 34), whereas the SI ratio was reduced in 15/34 (44.1%) patients. Mean healing time was significantly related to the baseline contrast medium uptake rate (P=0.005); it was 5.3 ± 2.7 months in patients with contrast medium uptake rate ≤100%, compared with 9.1 ± 2.5 months in the remaining patients (P=0.0003). Contrast medium uptake rate obtained at D-MRI represents a reproducible parameter that is reliable for predicting and monitoring treatment outcome in acute Charcot foot. (orig.)

  11. Role of dynamic MRI in the follow-up of acute Charcot foot in patients with diabetes mellitus

    Energy Technology Data Exchange (ETDEWEB)

    Zampa, Virna; Bargellini, Irene; Turini, Francesca; Ortori, Simona; Bartolozzi, Carlo [University of Pisa, Department of Diagnostic and Interventional Radiology, Pisa (Italy); Rizzo, Loredana; Piaggesi, Alberto [University of Pisa, Department of Endocrinology and Metabolism, Diabetic Foot Section, Pisa (Italy)

    2011-08-15

    To evaluate the usefulness of magnetic resonance imaging (MRI) in assessing the level of activity of acute Charcot foot, monitoring treatment response and predicting healing time. Forty diabetic patients with acute Charcot foot were prospectively enrolled. Patients underwent limb immobilization and were followed every 3 months by clinical examination (skin temperature and circumferences) and MRI. MR protocol included T1-weighted and fast spin echo inversion recovery (FSE-IR) sequences, and a dynamic study (fast spoiled gradient echo), after gadolinium administration (0.1 ml/kg). The contrast medium uptake rate at D-MRI and the signal intensity (SI) ratio on the FSE-IR sequence were measured. At baseline, mean contrast medium uptake rate was 136{+-}49.7% and the mean SI ratio was 5{+-}3. A high intra- and inter-observer agreement was found for the contrast medium uptake rate, whereas a low agreement was observed for the SI ratio. At 3 months' follow-up, reduction of the contrast medium uptake rate was observed in all patients with improved clinical findings (n = 34), whereas the SI ratio was reduced in 15/34 (44.1%) patients. Mean healing time was significantly related to the baseline contrast medium uptake rate (P=0.005); it was 5.3 {+-} 2.7 months in patients with contrast medium uptake rate {<=}100%, compared with 9.1 {+-} 2.5 months in the remaining patients (P=0.0003). Contrast medium uptake rate obtained at D-MRI represents a reproducible parameter that is reliable for predicting and monitoring treatment outcome in acute Charcot foot. (orig.)

  12. Aerobic anti-gravity exercise in patients with Charcot-Marie-Tooth disease types 1A and X

    DEFF Research Database (Denmark)

    Knak, Kirsten L; Andersen, Linda K; Vissing, John

    2017-01-01

    Background: Charcot-Marie-Tooth (CMT) disease is a hereditary neuropathy associated with impaired walking capacity. Some patients are too weak in the lower extremity muscles to walk at gravity with sufficient intensity or duration to gain benefit. Aim: The aim was to investigate the effect...... of aerobic anti-gravity exercise in weak patients with CMT 1A and X. Methods: Five adult patients performed moderate-intensity aerobic anti-gravity exercise 3/week for 10 weeks. Results: There was a significant positive difference in Berg balance scale and postural stability test between test occasions...

  13. Relapsing Remitting Multiple Sclerosis in X-Linked Charcot-Marie-Tooth Disease with Central Nervous System Involvement

    OpenAIRE

    Koutsis, Georgios; Karadima, Georgia; Floroskoufi, Paraskewi; Raftopoulou, Maria; Panas, Marios

    2015-01-01

    We report a patient with relapsing remitting multiple sclerosis (MS) and X-linked Charcot-Marie-Tooth disease (CMTX), carrying a GJB1 mutation affecting connexin-32 (c.191G>A, p. Cys64Tyr) which was recently reported by our group. This is the third case report of a patient with CMTX developing MS, but it is unique in the fact that other family members carrying the same mutation were found to have asymptomatic central nervous system (CNS) involvement (diffuse white matter hyperintensity on bra...

  14. Grizzly bear denning chronology and movements in the Greater Yellowstone Ecosystem

    Science.gov (United States)

    Haroldson, Mark A.; Ternent, Mark A.; Gunther, Kerry A.; Schwartz, Charles C.

    2002-01-01

    Den entrance and emergence dates of grizzly bears (Ursus arctos) in the Greater Yellowstone Ecosystem are important to management agencies that wish to minimize impacts of human activities on bears. Current estimates for grizzly bear denning events use data that were collected from 1975–80. We update these estimates by including data obtained from 1981–99. We used aerial telemetry data to estimate week of den entry and emergence by determining the midpoint between the last known active date and the first known date denned, as well as the last known date denned and the first known active date. We also investigated post emergence movement patterns relative to den locations. Mean earliest and latest week of den entry and emergence were also determined. Den entry for females began during the fourth week in September, with 90% denned by the fourth week of November. Earliest den entry for males occurred during the second week of October, with 90% denned by the second week of December. Mean week of den entry for known pregnant females was earlier than males. Earliest week of den entry for known pregnant females was earlier than other females and males. Earliest den emergence for males occurred during the first week of February, with 90% of males out of dens by the fourth week of April. Earliest den emergence for females occurred during the third week of March; by the first week of May, 90% of females had emerged. Male bears emerged from dens earlier than females. Denning period differed among classes and averaged 171 days for females that emerged from dens with cubs, 151 days for other females, and 131 days for males. Known pregnant females tended to den at higher elevations and, following emergence, remained at higher elevation until late May. Females with cubs remained relatively close (grizzly bear populations in the southern Rocky Mountains. 

  15. Balance and muscle power of children with Charcot-Marie-Tooth.

    Science.gov (United States)

    Silva, Tais R; Testa, Amanda; Baptista, Cyntia R J A; Marques, Wilson; Mattiello-Sverzut, Ana C

    2014-01-01

    In certain diseases, functional constraints establish a greater relationship with muscle power than muscle strength. However, in hereditary peripheral polyneuropathies, no such relationship was found in the literature. In children with Charcot-Marie-Tooth (CMT), to identify the impact of muscle strength and range of movement on the static/dynamic balance and standing long jump based on quantitative and functional variables. The study analyzed 19 participants aged between 6 and 16 years, of both genders and with clinical diagnoses of CMT of different subtypes. Anthropometric data, muscle strength of the lower limbs (hand-held dynamometer), ankle and knee range of movement, balance (Pediatric Balance Scale) and standing long jump distance were obtained by standardized procedures. For the statistical analysis, Pearson and Spearman correlation coefficients were used. There was a strong positive correlation between balance and the muscle strength of the right plantar flexors (r=0.61) and dorsiflexors (r=0.59) and a moderate correlation between balance and the muscle strength of inversion (r=0.41) and eversion of the right foot (r=0.44). For the long jump and range of movement, there was a weak positive correlation with right and left plantar flexion (r=0.20 and r=0.12, respectively) and left popliteal angle (r=0.25), and a poor negative correlation with left dorsiflexion (r=-0.15). The data on the patients analyzed suggests that the maintenance of distal muscle strength favors performance during balance tasks, while limitations in the range of movement of the legs seem not to be enough to influence the performance of the horizontal long jump.

  16. Poor compliance with ankle-foot-orthoses in Charcot-Marie-Tooth disease.

    Science.gov (United States)

    Vinci, P; Gargiulo, P

    2008-03-01

    The aim of this study is to evaluate the compliance with ankle-foot orthoses (AFOs) in patients previously prescribed and affected with Charcot-Marie-Tooth disease (CMT). Twenty-five Italian patients (8 males 17 females; mean age: 41.6 years, range 16-54) with severe bilateral footdrop (leg-sole angle alpha >105 degrees ) alone or associated with other problems (rotation, plantarflexor failure, knee flexor failure) were examined by a physiatrist (with measurement of the leg-sole angle alpha' with their footwear) and interviewed by a psychologist. Only 5 patients (20%) used AFOs (3 prefabricated polypropylene AFOs, 2 custom-made short AFOs incorporated in high-top boots) with satisfactory functional results (alpha' <=94 degrees ; reported increased mobility and no more falls). The interview revealed that all patients had a bad relationship with their own body. The 3 subjects using prefabricated AFOs said that they hated them and one of them complained of pain. Patients not using AFOs justified their decision with statements such as: ''I am not yet ready to accept them'' (n=3) or ''I can still manage without them for a while'' (n=2) or both (n=15). Four patients had experienced pain during the trial, 2 had not found proper shoes to accommodate them and 12 were absolutely not interested in AFOs and, therefore, had not gone to an orthotist. Compliance with AFOs is poor. Patients with CMT discard AFOs because they highlight their disability, are not essential for their limited daily walking and are uncomfortable. We suggest that prescription of AFOs be accompanied with psychological support and that research of more comfortable and cosmetically acceptable solutions for the problem of footdrop be stimulated.

  17. Duplication in chromosome 17p11.2 in Charcot-Marie-Tooth neuropathy type 1a (CMT 1a). The HMSN Collaborative Research Group

    NARCIS (Netherlands)

    Raeymaekers, P.; Timmerman, V.; Nelis, E.; de Jonghe, P.; Hoogendijk, J. E.; Baas, F.; Barker, D. F.; Martin, J. J.; de Visser, M.; Bolhuis, P. A.

    1991-01-01

    Hereditary motor and sensory neuropathy type I (HMSN I) or Charcot-Marie-Tooth disease type 1 (CMT 1) is an autosomal dominant disorder of the peripheral nervous system characterized by progressive weakness and atrophy of distal limb muscles. In the majority of HMSN I families, linkage studies

  18. Duration of off-loading and recurrence rate in Charcot osteo-arthropathy treated with less restrictive regimen with removable walker

    DEFF Research Database (Denmark)

    Christensen, Tomas M; Gade-Rasmussen, Birthe; Pedersen, Lis W

    2013-01-01

    Recent literature on acute diabetic Charcot osteoarthropathy (CA) reports unusually long periods of off-loading. Data suggest that this might increase the re-currence rate. Subsequently we evaluated the influence of duration of off-loading on the risk of required re-casting....

  19. Development of an IoT early-warning temperature home-monitoring system for diabetic foot ulcer-or Charcot-feet patients

    DEFF Research Database (Denmark)

    Dittmann, Lars; Petersen, Martin Nordal; Yderstræde, Knud Bonnet

    2017-01-01

    In severe cases, diabetic patients can develop ulcers at the feet and lower leg regions.This,together with a condition called Charcot-foot, can lead to severe wounds, numbness and eventually amputation. There are ways to treat the condition, but the key element is early-warning and early treatment....

  20. Viability of permanent PMMA spacer with combined free fasciocutaneous tissue transfer for failed charcot reconstruction: A 38 month prospective case report

    Directory of Open Access Journals (Sweden)

    Tammer Elmarsafi

    Full Text Available Introduction: Charcot Neuroarthropathy is a complex lower extremity pathology which predisposes the afflicted limb to ulcerations, osteomyelitis, and risk of major amputation. Charcot Neuroarthropathy often requires osseous reconstruction, which can be complicated with osteomyelitis and hardware infection. When soft tissue and osseous deficits must be concomitantly addressed, the use of PMMA spacers can be combined with free tissue transfers. Presentation of case: 71 year old Caucasian male with Diabetic Charcot Neuroarthopathy underwent osseous reconstruction with internal hardware. The surgical site was complicated by acute infection, osteomyelitis, exposed hardware requiring removal, and multiple surgical débridement. The degree of soft tissue and osseous deficit post-débridement required complex reconstruction. Discussion: The osseous deficit was addressed with the use of a permanent PMMA cement spacer. The soft tissue deficit was reconstructed with a free tissue transfer. This case report demonstrates the long term viability and utility of the use of permanent cement spacers when combined with free tissue transfer for closure of complex diabetic foot wounds. This case is an example of a multidisciplinary team approach to limb salvage with successful long term outcome; a plantigrade stable functional foot in an ambulatory highly active patient. Follow up time since initial intervention was 38 months. Conclusion: The use of a permanent PMMA cement spacer does not preclude free tissue transfer in complex host lower extremity reconstruction. A multidisciplinary team approach is a vital component to successful salvage outcomes. Keywords: Diabetes, Charcot neuroarthropathy, Ulcer, Cement spacer, Free tissue transfer, Osteomyelitis

  1. Novel mutations in the PRX and the MTMR2 genes are responsible for unusual Charcot-Marie-Tooth disease phenotypes.

    Science.gov (United States)

    Nouioua, Sonia; Hamadouche, Tarik; Funalot, Benoit; Bernard, Rafaëlle; Bellatache, Nora; Bouderba, Radia; Grid, Djamel; Assami, Salima; Benhassine, Traki; Levy, Nicolas; Vallat, Jean-Michel; Tazir, Meriem

    2011-08-01

    Autosomal recessive Charcot-Marie-Tooth diseases, relatively common in Algeria due to high prevalence of consanguineous marriages, are clinically and genetically heterogeneous. We report on two consanguineous families with demyelinating autosomal recessive Charcot-Marie-Tooth disease (CMT4) associated with novel homozygous mutations in the MTMR2 gene, c.331dupA (p.Arg111LysfsX24) and PRX gene, c.1090C>T (p.Arg364X) respectively, and peculiar clinical phenotypes. The three patients with MTMR2 mutations (CMT4B1 family) had a typical phenotype of severe early onset motor and sensory neuropathy with typical focally folded myelin on nerve biopsy. Associated clinical features included vocal cord paresis, prominent chest deformities and claw hands. Contrasting with the classical presentation of CMT4F (early-onset Dejerine-Sottas phenotype), the four patients with PRX mutations (CMT4F family) had essentially a late age of onset and a protracted and relatively benign evolution, although they presented marked spine deformities. These observations broaden the spectrum of clinical phenotypes associated with these two CMT4 forms. Copyright © 2011 Elsevier B.V. All rights reserved.

  2. A Rare Case of Charcot-Mari-Tooth Disease Type 2S in a 20-year-old Man

    Directory of Open Access Journals (Sweden)

    Natalia A. Shnayder

    2017-12-01

    Full Text Available Charcot-Marie-Tooth disease type 2 (CMT2S is rare form of Charcot-Marie-Tooth disease (CMT that is characterized by a mutation in the IGHMBP2 gene. This gene encodes a helicase superfamily member that binds a specific DNA sequence from the region of the immunoglobulin mu chain switch. Mutation of this gene leads to spinal muscle atrophy with respiratory distress type 1 and CMT2S. This case report presents a 20-year-old male with genetically confirmed CMT2S having clinical respiratory involvement and symmetrically involved lower extremities. DNA sequencing revealed a previously unknown heterozygous mutation in the exone 2 of the IGHMBP2 gene leading to the replacement of the amino acid in the 46 position of the protein (chr11q13.3: 68673587 G>C. These atypical features widen the clinical spectrum of CMT2S. In describing this clinical case, we also improve diagnostic management and try to increase the alertness of various doctors towards neuromuscular diseases, including CMT.

  3. Fox Den Disease: An Interesting Case Following Delayed Diagnosis.

    Science.gov (United States)

    Stehr, Ryan C; Kim, Nicholas; LoGiudice, John A; Ludwig, Kirk

    2015-06-01

    Pyoderma fistulans sinifica, also known as fox den disease, is a rare and poorly understood inflammatory disorder of the skin and subcutaneous tissues. This disorder is often mistaken for other inflammatory skin disorders and treated inappropriately. The authors describe the case of a 53-year-old male who presented to the colorectal surgery service with a longstanding diagnosis of perirectal Crohn's disease. Despite aggressive immunosuppression and numerous surgical procedures, the patient continued to have unrelenting purulent drainage from the skin of his buttocks. Following wide excision of the affected skin and subcutaneous tissues by the colorectal surgeon, the plastic surgery team reconstructed the 30 cm x 55 cm wound using a combination of local flaps and skin grafts. The initial pathology report of the excised specimen confirmed the presence of nonspecific abscesses and inflammation. Upon special request by the plastic surgery team, the sample was resectioned with the specific intent of establishing a diagnosis of fox den disease. The additional slides met the criteria for an unequivocal diagnosis of fox den disease. Immunosuppression was discontinued and the patient healed his wounds without complication. Fox den disease is often overlooked because of the obscurity of the disease and the special histological sectioning needed to establish a diagnosis. In this case, the patient was unnecessarily treated with immunosuppressive drugs for more than 3 decades because of a misdiagnosis. With increased awareness of fox den disease, perhaps its pathophysiology can be better elucidated as more patients are appropriately diagnosed and treated.

  4. American black bear denning behavior: Observations and applications using remote photography

    Science.gov (United States)

    Bridges, A.S.; Fox, J.A.; Olfenbuttel, C.; Vaughan, M.B.

    2004-01-01

    Researchers examining American black bear (Ursus americanus) denning behavior have relied primarily on den-site visitation and radiotelemetry to gather data. Repeated den-site visits are time-intensive and may disturb denning bears, possibly causing den abandonment, whereas radiotelemetry is sufficient only to provide gross data on den emergence. We used remote cameras to examine black bear denning behavior in the Allegheny Mountains of western Virginia during March-May 2003. We deployed cameras at 10 den sites and used 137 pictures of black bears. Adult female black bears exhibited greater extra-den activity than we expected prior to final den emergence, which occurred between April 12 and May 6, 2003. Our technique provided more accurate den-emergence estimation than previously published methodologies. Additionally, we observed seldom-documented behaviors associated with den exits and estimated cub age at den emergence. Remote cameras can provide unique insights into denning ecology, and we describe their potential application to reproductive, survival, and behavioral research.

  5. Dansk udlevering efter den europæiske arrestordre

    DEFF Research Database (Denmark)

    Elholm, Thomas; Bang Fuglsang Madsen Sørensen, Henning

    2016-01-01

    Den europæiske arrestordre, der blev vedtaget af EU i 2002, har haft stor betydning for retsudviklingen vedrørende udlevering af personer til strafforfølgning eller strafafsoning i EU. Danmark er - trods retsforbeholdet - fuldt ud med i ordningen om arrestordren, og mange danske domstole har...... efterhånden haft sådanne sager. Det har givet anledning til en række vanskelige juridiske spørgsmål. I den sidste tid har det især drejet sig om, hvorvidt udlevering kan afslås med henvisning til urimelige fængselsforhold i andre lande. EU-domstolen har den 5. april 2016 afsagt en vigtig dom om spørgsmålet...

  6. Filosofisk terapi som træning til døden

    DEFF Research Database (Denmark)

    Dræby, Anders

    Den eksistentielfænomenologiske terapi deler den opfattelse med stoicismen, at filosofiens hovedopgave er at hjælpe mennesket med at finde vej i en problematisk verden. Oplægget udforsker desuden et overlap, som består i den indsigt, at terapeutisk udfrielse fra menneskelig lidelse til livsduelig......Den eksistentielfænomenologiske terapi deler den opfattelse med stoicismen, at filosofiens hovedopgave er at hjælpe mennesket med at finde vej i en problematisk verden. Oplægget udforsker desuden et overlap, som består i den indsigt, at terapeutisk udfrielse fra menneskelig lidelse til...

  7. Diana og Kirke. Den klassiske mytes metamorfose i italienske Renæssance

    DEFF Research Database (Denmark)

    Cecchini, Leonardo

    Den klassiske myte har en særlig stilling i det, Aleida Assmann har kaldt kulturelle Gedächtnis. Takket være dens store udbredelse i den vestlige kultur (både i litteratur, kunst og i andre områder), har den en tendens til at virke, snarere end som konkret ”tekst”, som et udbredt kulturel registe...... renæssancekulturen omarbejder den klassiske myte. Som case-stories vil jeg anvende Kirke-myten og ”den mytiske jagt” (Diana og Aktæon) og vise, hvordan de bliver genanvendt, tilpasset og fortolket i tekster af Petrarca, Boccaccio, Machiavelli og Gelli....

  8. Facial Cellulitis Arising from Dens Evaginatus: A Case Report

    Directory of Open Access Journals (Sweden)

    Chun-Ming Chen

    2005-07-01

    Full Text Available Dens evaginatus is a developmental anomaly that produces a tubercle on the occlusal surface of a tooth. It is found most frequently in the mandibular premolars. The occlusal tubercle easily causes occlusal interferences. Attrition or fracture of the tubercle can lead to pulpitis, pulp necrosis, periapical pathosis, and periapical infection. This case report illustrates the treatment of facial cellulitis arising from dens evaginatus with open apex. Calcium hydroxide was used for the apexification procedure. One year after canal obturation, radiography revealed no apical pathosis and the apical seal was evident.

  9. Die Umweltschäden und Entsorgungsprobleme des russischen Nuklearkomplexes

    OpenAIRE

    Kronfeld-Goharani, Ulrike

    2002-01-01

    "Als Nachfolgestaat der ehemaligen Sowjetunion mit ihrer gigantischen Nuklearindustrie zählt Russland heute zu den Ländern, in denen sich große Mengen Nuklearmüll angereichert haben und einzelne Regionen des Landes von radioaktiven Kontaminationen besonders stark betroffen sind. Ungeachtet dessen änderte im Juni 2001 das russische Parlament das Umweltgesetz, um verbrauchten Nuklearbrennstoff aus dem Ausland in großen Mengen zu importieren. Während Befürworter der Gesetzesänderungen den Import...

  10. Financial Inclusion: Reformen in den Bereichen Verbraucherschutz und finanzielle Allgemeinbildung

    OpenAIRE

    Christa Hainz

    2011-01-01

    Nicht zuletzt der Mangel an wirksamer Offenlegung von Informationen und irreführende Werbung auf Seiten der Anbieter sowie mangelndes Verständnis bezüglich Finanzprodukten auf Seiten der Konsumenten trugen dazu bei, dass der Markt für Subprime-Hypotheken in den USA zusammenbrach. Eine Verbesserung dieses institutionellen Umfelds sollte deshalb dazu dienen, derart negative Entwicklungen in der Zukunft zu verhindern. Der Beitrag gibt einen Überblick, welche Industrieländer Reformen in den Berei...

  11. Kurz zum Klima: Zu viel Salz verdirbt den Boden

    OpenAIRE

    Zimmer, Markus; Lippelt, Jana; Frank, Jonas

    2012-01-01

    Der zunehmende Einsatz von Anlagen zur Bewässerung sowie mangelnde Erfahrungswerte und Unkenntnis über den richtigen Einsatz der künstlichen Bewässerung haben in den letzten Jahrzehnten zu einer massiven Zunahme der Versalzung des Bodens geführt. Durch diese Bodenversalzung werden weite Flächen für die Landwirtschaft unbrauchbar. Sie sind nur durch hohen Aufwand und Kosten wieder renaturierbar. Der Beitrag in der Reihe »Kurz zum Klima« gibt einen Überblick über die Versalzung in Anbaugebiet...

  12. Temperature, salinity, nutrients, oxygen, chlorophyll and other measurements found in dataset SISMER taken from the VAUBAN, JEAN CHARCOT (FNOY) and other platforms in the South Pacific, Coastal North Atlantic and other locations from 1983 to 2007 (NODC Accession 0046621)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Temperature, salinity, nutrients, oxygen, chlorophyll and other measurements found in CTD and OSD datasets taken from the VAUBAN, JEAN CHARCOT (FNOY) and other...

  13. Hemmelig ransagning og brevstandsning i den digitale virkelighed

    DEFF Research Database (Denmark)

    Lentz, Lene Wacher

    2016-01-01

    Artiklen tager udgangspunkt i sager om databedrageri, hvor betalingskort misbruges til køb på internettet. Politiets adgang til private chatfora på nettet analyseres i forhold til de straffeprocessuelle tvangsindgreb hemmelig ransagning, aflytning og dataaflæsning. Desuden behandler artiklen den ...

  14. Activity rhythms and distribution of natal dens for red foxes

    Science.gov (United States)

    Wenyang, Zhou; Wanhong, Wei; Biggins, Dean E.

    1995-01-01

    The red fox, Vulpes vulpes, was investigated with snow tracking, radiotracking and directive observation at the Haibei Research Station of Alpine Meadow Ecosystem, Academia Sinica, from March to September 1994. The objectives of this study were to determine the distribution and use of natal dens, activity rhythms, and home range sizes for the foxes.

  15. Der Effekt von Hohlraumströmung auf den Druckausgleich

    NARCIS (Netherlands)

    Bentum, van C.A.; Suma, A.B.; Kalkman, I.M.; Koster, T.; Geurts, C.P.W.; Ruscheweyh, xx

    2011-01-01

    KURZFASSUNG. Hinterlüftete Fassaden sind ein häufig verwendetes System der Verkleidung. Auf der Vorderseite eines Hohlraums wird eine durchlässige äußere Schichtangebracht. Über den Raum selbst wird ein Druckausgleich zwischen der Außenseite und der Innenseite des Hohlraums erzielt. Dieser Effekt

  16. Cloud computing og den strafferetlige beskyttelse af data

    DEFF Research Database (Denmark)

    Mathiasen, Peter Dueholm

    2013-01-01

    Cloud computing er blevet en populær metode for bl.a. at opbevare data. Muligheden for eksempelvis at placere forretningskritiske data på teknisk udstyr, som ejes af den udbyder, der driver cloud computing tjenesten, gør det aktuelt at forholde sig til, om straffeloven i sådanne tilfælde yder et...

  17. Datenschutz in den sozialen Medien aus privatrechtlicher Perspektive

    Directory of Open Access Journals (Sweden)

    Hager, Johannes

    2017-12-01

    Full Text Available Der Datenschutz in den sozialen Medien wirft eine Reihe von Problemen auf. Zum einen geht es um das Verhältnis des Datenschutzgesetzes zum Persönlichkeitsrecht; hier wird sich eine Kombinationslehre wie bei sonstigen besonderen Persönlichkeitsrechten – etwa dem Bildnisschutz – als überlegen erweisen. Die §§ 7 ff dTMG privilegieren die Provider in mehrfacher Hinsicht. Freilich bleibt deren Haftung oft unberührt. So kann der Content-Provider zur Verantwortung gezogen werden auch wenn er sich fremde Nachrichten nur zu eigen macht. Der Host-Provider haftet ab Kenntnis des rechtswidrigen Inhalts; auch treffen ihn eine Reihe von Prüfungspflichten. Entgegen der Auffassung des BGH ist er auch verpflichtet, den Namen des Content-Providers zu nennen. Schließlich kommt eine Haftung des Access-Providers in Betracht, wenn er die rechtswidrigen Inhalte wissentlich weiterleitet. Entgegen der Auffassung des EuGH besteht ein Gerichtsstand überall dort, wo sich die unerlaubte Handlung – die Verletzung des Persönlichkeitsrechts – verwirklicht; sie ist nicht auf den Tatort und den Ort beschränkt, an dem sich das Opfer befindet.

  18. Tendenser inden for den nyere fagsprogsforskning i Danmark

    DEFF Research Database (Denmark)

    Bergenholtz, Henning; Engberg, Jan

    1995-01-01

    I artiklen præsenteres hovedtendenserne i den fagsproglige forskning, der er foregået specielt med rod i handelshøjskolerne i Danmark i de seneste 25 år. Efter en indledning om fagsprogsbegreber og rammerne for fagsproglig forskning i Danmark præsenteres fagsproglige arbejder inden for områderne ...

  19. Corporate Social Responsibility i forsyningskæden

    DEFF Research Database (Denmark)

    Liempd, Dennis van

    2007-01-01

    Styring og kontrol af etiske risici i forsyningskæden som en del af virksomhedens samfundsansvar (corporate social re­sponsibility; CSR) er blevet mere og mere vigtig nu til dags. Der er stor national og international fokus på CSR-området, ikke mindst fordi globaliseringen har gjort, at flere...

  20. Hyekyung Cho: Chinas langer Marsch in den Kapitalismus

    DEFF Research Database (Denmark)

    Czeskleba-Dupont, Rolf

    2006-01-01

    Chos afhandling fra Berlin refereres i hovedtræk. Tre modsætninger tages op i den: 1) mellem 'transitionen' ind i kapitalismen og herredømmet af et kommunistisk parti, hvor det bl.a.viser sig at particentralen fremmer liberaliseringen i kampen mod statsvirksomhederne; 2) mellem integrationen i ve...

  1. Rum, rammer og biblioteker i den virtuelle verden

    DEFF Research Database (Denmark)

    Heilesen, Simon

    2009-01-01

    Med udgangspunkt i en kort introduktion til hvordan rum og rammer gestaltes i den virtuelle 3‐D verden Second Life, undersøger denne artikel, på hvilke måder rum og rammesætning anvendes og opleves i en faglig sammenhæng. Som eksempel anvendes det danske biblioteksprojekt i Second Life, Info Island...

  2. Barnehagen, læring og den nasjonale konkurranseevnen

    DEFF Research Database (Denmark)

    Krejsler, John B.

    2013-01-01

    , og som har røtter i reformpedagogikken, havner dermed under press. Dette gir konkurransestatens forestillinger om danning en fordel, som er mer inspirert av teorien om rasjonelle valg (rational choice theory), og som fokuserer på «den opportunistiske person» som gjennom livslang læring utvikler sin...

  3. Zum Vorkommen von Kalkglimmern (Margarit, Cintonit) in den Schweizer Alpen

    NARCIS (Netherlands)

    Niggli, E.

    1955-01-01

    In einem ersten Abschnitt stellt der Verfasser die ihm bekannten Literaturstellen zusammen. Im zweiten Abschnitt werden eigene Untersuchungen beschrieben, die als vorläufiges Resultat ergaben, dass Clintonit in den Schweizer Alpen bislang nicht einwandfrei nachgewiesen ist, dass aber Margarit ein

  4. Mikrokredittens globale fortælling og dens etiske problemstillinger

    DEFF Research Database (Denmark)

    Jensen, Thessa

    2011-01-01

    , men har netop fået en ny drejning med anklager om korruption mod en af mikrokredittens fædre, Mohammad Yunus1. Denne artikel prøver at fokusere på de etiske problemstillinger, som er mikrokreditten iboende. Etiske problemer, som ikke umid- delbart synes særlig belyst i den foreliggende litteratur om...

  5. Kapitalismens ånd og den kreative etik

    DEFF Research Database (Denmark)

    Stephensen, Jan Løhmann

    Chiapellos tese om kapitalismens permanente behov for ny legitimering analyserer Jan Løhmann Stephensen nutidens koblinger mellem arbejde, kreativitet og økonomi som et svar på de kritikker af kapitalismen og lønarbejdet, som blev fremsat i anden halvdel af det 20. århundrede, typisk med den unge Karl Marx...

  6. Teopæd-opgaven og den fagdidaktiske udfordring

    DEFF Research Database (Denmark)

    Hobel, Peter

    2014-01-01

    Artiklen diskuterer nødvendigheden af at styrke det fagdidaktiske perspektiv i 'teopæd-opgaven' - den opgave, som gymnasielærere i uddannelsesstilling skriver ved slutningen af året i uddannelsesstillingen. Artiklen diskuterer, hvad fag er, hvad forholdet er mellem almendidaktik og fagdidaktik, o...

  7. Dijk- en oeverval aan den cal. Willem Annapolder (Gem. Kapelle)

    NARCIS (Netherlands)

    Verhagen, H.J.

    1936-01-01

    Foto's van de aanleg van de dijk- en oeverval aan den cal. Willem Annapolder (Gem. Kapelle) 3. Linkerhelft dijkval Willem Annapolder. 30 Dec. 1936 4. Rechtehelft dijkval Willem Annapolder. 30 Dec. 1936 5. Overzicht dijkval Willem Annaolder. 30 Dec. 1936 6. Kleikisting binnendijks aangebacht. 14/15

  8. Begrundelser for ytringsfriheden og dens grænser

    DEFF Research Database (Denmark)

    Lægaard, Sune

    2007-01-01

    såkaldte skadesprincip, der ofte antages at udelukke den type begrænsninger af ytringsfriheden, som fx findes i racismeparagraffen. Skadesprincippet udelukker dog ikke sådanne begrænsninger, men en fuld retfærdiggørelse af dem kræver en bredere begrundelse, og anerkendelse af minoriteters ligeværd...

  9. Om den sociale og symbolske funktion af uddannelsesevalueringer

    DEFF Research Database (Denmark)

    Nørholm, Morten

    Afhandlingens teoretiske udgangspunkt er hos Émile Durkheim, Pierre Bourdieu, Ulf P. Lund­gren, Staf Callewaert, det konkrete er en række evalueringer af uddannelser til (semi)professioner inden for sundhedssektoren.                I afhandlingen konstrueres den sociale og symbolske funktion af...

  10. Den historiske roman for børn

    DEFF Research Database (Denmark)

    Skyggebjerg, Anna Karlskov

    Bogen indeholder en redegørelse for den historiske roman som børnelitterær genre. Genren diskuteres i et teoretisk, historisk og analytisk perspektiv. Bogen afsluttes med en række principielle didaktiske overvejelser. Bogen er henvendt til alle, der beskæftiger sig professionelt med børnelitteratur...

  11. An Interview with DOROTHY E. DENNING, Oral History 424

    OpenAIRE

    Yost, Jeffrey R.

    2013-01-01

    Computer Security History Project Computer security pioneer Dorothy Denning discusses her career including her Lattice Model for Computer Security, research on database security, intrusion detection, and other areas, such as her influential textbooks. The interview also addresses computer security research infrastructure and collaborators at various institutions where she worked including Purdue University, SRI International, Digital Equipment Corporation, Georgetown University, and Naval ...

  12. Skønhed og rædsel i den nye Pharma Science Building

    DEFF Research Database (Denmark)

    Reeh, Henrik

    2016-01-01

    Reportage fra et fælles besøg i den nyligt indviede PharmaScience Building, Københavns Universitet, juni 2016. Teksten om mødet mellem journalist og forsker på den ene side og bygningen og dens brugere på den anden side. Journalist Christoffer Zieler henviser til Henrik Reehs separat offentliggjo......Reportage fra et fælles besøg i den nyligt indviede PharmaScience Building, Københavns Universitet, juni 2016. Teksten om mødet mellem journalist og forsker på den ene side og bygningen og dens brugere på den anden side. Journalist Christoffer Zieler henviser til Henrik Reehs separat...

  13. Emma Bentz: I stadens skugga. Den medeltida landsbygden som arkeologiskt forskningsfält

    DEFF Research Database (Denmark)

    Kristiansen, Mette Svart

    2009-01-01

    Anmeldelse af doktordisputats, Lunds Universitet. Afhandlingen omhandler etableringen af den middelalderlige landbebyggelse som arkæologisk forskningsfelt fra 1930érne til i dag samt etableringen og vedligeholdelsen af et forskningsfelt indenfor den humanistiske videnskab....

  14. Asymptomatic ''crowned dens'' calcification in CT images for the craniovertebral junction

    International Nuclear Information System (INIS)

    Kubota, Gen; Mori, Masataka; Fukushima, Tatsuro

    2007-01-01

    Calcification around the odontoid process suggests 'crowned dens' syndrome, when accompanied with acute occipital headache or neck pain and with inflammatory signs. We retrospectively searched for calcification around the odontoid process in routine CT images of 282 patients emcompassing the craniovertebral junction, and found 13 (4.6%) had 'crowned dens' calcifications with neither characteristic symptoms nor signs suggestive for crowned dens' syndrome. Females of older ages frequently showed asymptomatic crowned dens' calcifications. (author)

  15. Clinical and neurophysiological investigation of a large family with dominant Charcot-Marie-Tooth type 2 disease with pyramidal signs

    Directory of Open Access Journals (Sweden)

    Eduardo Luis de Aquino Neves

    2011-06-01

    Full Text Available Charcot-Marie-Tooth (CMT disease is a hereditary neuropathy of motor and sensory impairment with distal predominance. Atrophy and weakness of lower limbs are the first signs of the disease. It can be classified, with the aid of electromyography and nerve conduction studies, as demyelinating (CMT1 or axonal (CMT2. OBJECTIVE: Clinical and neurophysiological investigation of a large multigenerational family with CMT2 with autosomal dominant mode of transmission. METHOD: Fifty individuals were evaluated and neurophysiological studies performed in 22 patients. RESULTS: Thirty individuals had clinical signs of motor-sensory neuropathy. Babinski sign was present in 14 individuals. Neurophysiological study showed motor-sensory axonal polyneuropathy. CONCLUSION: The clinical and neurophysiological characteristics of this family does not differ from those observed with other forms of CMT, except for the high prevalence of Babinski sign.

  16. Coexistent Charcot-Marie-Tooth type 1A and type 2 diabetes mellitus neuropathies in a Chinese family

    Directory of Open Access Journals (Sweden)

    A-ping Sun

    2015-01-01

    Full Text Available Charcot-Marie-Tooth disease type 1A (CMT1A is caused by duplication of the peripheral myelin protein 22 (PMP22 gene on chromosome 17. It is the most common inherited demyelinating neuropathy. Type 2 diabetes mellitus is a common metabolic disorder that frequently causes predominantly sensory neuropathy. In this study, we report the occurrence of CMT1A in a Chinese family affected by type 2 diabetes mellitus. In this family, seven individuals had duplication of the PMP22 gene, although only four had clinical features of polyneuropathy. All CMT1A patients with a clinical phenotype also presented with type 2 diabetes mellitus. The other three individuals had no signs of CMT1A or type 2 diabetes mellitus. We believe that there may be a genetic link between these two diseases.

  17. Gait rehabilitation in a patient affected with Charcot-Marie-Tooth disease associated with pyramidal and cerebellar features and blindness.

    Science.gov (United States)

    Vinci, Paolo

    2003-05-01

    Charcot-Marie-Tooth (CMT) disease, an inherited neuropathy characterized by length-dependent degeneration of the motor and sensory nerve fibers with consequent distal muscle atrophy and sensory reduction, can be associated with symptoms and signs of involvement of the central nervous system and/or cranial nerves. We present a patient with relatively severe CMT, cerebellar ataxia, pyramidal involvement, and blindness due to Leber's hereditary optic neuropathy. The patient presented with poor standing and gait, with consequent severe disability. Factors responsible for the patient's functional impairment (plantarflexor failure, footdrop, foot rotation, knee flexor contracture, poor proprioception, cerebellar dysfunction, spastic paraparesis, blindness) were identified and addressed by a rehabilitation management, which included, as a main intervention, ankle stabilization by drop-foot boots instead of ankle-foot orthoses. Improved balance and independent ambulation resulted from rehabilitation.

  18. Severe vincristine-induced polyneuropathy in a teenager with anaplastic medulloblastoma and undiagnosed Charcot-Marie-Tooth disease.

    Science.gov (United States)

    Aghajan, Yasmin; Yoon, Janet M; Crawford, John Ross

    2017-04-24

    Severe neuropathy is a known adverse effect of vincristine in patients with Charcot-Marie-Tooth disease (CMT). We present the case of a 16-year-old girl with anaplastic medulloblastoma treated with gross total resection and high-dose craniospinal radiation with adjuvant vincristine chemotherapy who developed acute-onset severe quadriplegia and vocal cord paralysis. Vincristine and radiation therapy were discontinued. Although her neuropathy slowly improved over several weeks, she developed metastatic extraneural medulloblastoma and died 5 months after diagnosis. Subsequent genetic testing revealed previously asymptomatic and undiagnosed CMT1A. Our case highlights the importance of early recognition of acute vincristine neurotoxicity that should raise suspicion of an underlying hereditary neuropathy. © BMJ Publishing Group Ltd (unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  19. Relapsing Remitting Multiple Sclerosis in X-Linked Charcot-Marie-Tooth Disease with Central Nervous System Involvement

    Directory of Open Access Journals (Sweden)

    Georgios Koutsis

    2015-01-01

    Full Text Available We report a patient with relapsing remitting multiple sclerosis (MS and X-linked Charcot-Marie-Tooth disease (CMTX, carrying a GJB1 mutation affecting connexin-32 (c.191G>A, p. Cys64Tyr which was recently reported by our group. This is the third case report of a patient with CMTX developing MS, but it is unique in the fact that other family members carrying the same mutation were found to have asymptomatic central nervous system (CNS involvement (diffuse white matter hyperintensity on brain MRI and extensor plantars. Although this may be a chance association, the increasing number of cases with CMTX and MS, especially with mutations involving the CNS, may imply some causative effect and provide insights into MS pathogenesis.

  20. Relapsing remitting multiple sclerosis in x-linked charcot-marie-tooth disease with central nervous system involvement.

    Science.gov (United States)

    Koutsis, Georgios; Karadima, Georgia; Floroskoufi, Paraskewi; Raftopoulou, Maria; Panas, Marios

    2015-01-01

    We report a patient with relapsing remitting multiple sclerosis (MS) and X-linked Charcot-Marie-Tooth disease (CMTX), carrying a GJB1 mutation affecting connexin-32 (c.191G>A, p. Cys64Tyr) which was recently reported by our group. This is the third case report of a patient with CMTX developing MS, but it is unique in the fact that other family members carrying the same mutation were found to have asymptomatic central nervous system (CNS) involvement (diffuse white matter hyperintensity on brain MRI and extensor plantars). Although this may be a chance association, the increasing number of cases with CMTX and MS, especially with mutations involving the CNS, may imply some causative effect and provide insights into MS pathogenesis.

  1. Mod en ny forståelse af den digitaliseringsstrategiske proces

    DEFF Research Database (Denmark)

    Ivang, Reimer

    2007-01-01

    Den digitale teknologi er vigtig, og vigtigheden kan ikke kun afspejles i den konstant stigende mængde af litteratur, der relaterer sig til fænomenet. Men vigtigheden er også identificeret på Danfoss, der er afhandlingens empiriske kontekst. Der synes at være enighed om, at den digitale teknologi...

  2. Frede P. Jensen og den danske indkredsning af Vasatidens Sverige 40 år efter

    DEFF Research Database (Denmark)

    Andersen, Dan H.

    2016-01-01

    Artiklen er en analyse af receptionen af Frede P. Jensens kritik af den svenske historiker Arthur Stilles indflydelsesrige teori fra 1918 om årsagerne den svenske stormagts opståen. Stilles teori så den svenske politik som et grundlæggende defensivt og eksistentielt svar på en dansk indkredsning af...

  3. Dwellers in dens on sandy bottoms: Ecological and behavioural traits of Octopus vulgaris

    Directory of Open Access Journals (Sweden)

    Ángel Guerra

    2014-09-01

    Full Text Available Four visual censuses targeting Octopus vulgaris living in dens on sandy bottoms were carried out from June to October 2013 in the National Park of the Atlantic Galician Islands (NW Spain. Censuses were undertaken by scuba diving between 5 and 21 m depth in daytime. The total area swept was 13.75 ha. There were no significant differences between octopus presence in dens during open and closed fishing seasons. Depth had a significant negative relationship with occupancy. The average number of dens per 1000 m2 was 3.84±0.84 in June and 3.89 in October. The area per den was 260 m2. Den number estimations varied between 1586 and 2057. The largest number of dens (76.5% was found between 5 and 10 m depth. Den distribution was clumped. No significant differences were found between octopus size classes (small, medium and large and den diameter. Associate dens were observed. There were no significant differences in den diameter and shell types found around the middens. Many dens could be “permanent”. Drilling bivalve shell behaviour is discussed. The surveyed area had around 1100 individuals, mainly small specimens. No significant differences were found between octopus size and depth. Substrate, den type and food abundance and availability (especially razors Ensis arcuatus seem to be the main factors influencing dens and octopus density and distribution. Den availability does not appear to be a limiting factor in this case. Temperature, den availability, predators and fishing pressure influencing density and distribution are discussed. Rodas inlet may be a preferential habitat for O. vulgaris individuals ranging from 200 to 2000 g, but especially small specimens ( ≤ 1000 g.

  4. Amiotrofia neuro-medular de Charcot-Marie-Tooth associada a artrogripose multipla congenita: registro de um caso e revisão da literatura

    Directory of Open Access Journals (Sweden)

    James Pitagoras de Mattos

    1982-09-01

    Full Text Available Os autores registram a associação da amiotrofia neuro-medular de Charcot-Marie-Tooth com artrogripose múltipla congênita. Mostram as associações com as duas condições em apreço na literatura, assim como acrescentam outras alterações observadas nos diversos exames radiológicos realizados.

  5. Loss of the E3 ubiquitin ligase LRSAM1 sensitizes peripheral axons to degeneration in a mouse model of Charcot-Marie-Tooth disease

    OpenAIRE

    Bogdanik, Laurent P.; Sleigh, James N.; Tian, Cong; Samuels, Mark E.; Bedard, Karen; Seburn, Kevin L.; Burgess, Robert W.

    2013-01-01

    SUMMARY Charcot-Marie-Tooth disease (CMT) is a clinically and genetically heterogeneous condition characterized by peripheral axon degeneration with subsequent motor and sensory deficits. Several CMT gene products function in endosomal sorting and trafficking to the lysosome, suggesting that defects in this cellular pathway might present a common pathogenic mechanism for these conditions. LRSAM1 is an E3 ubiquitin ligase that is implicated in this process, and mutations in LRSAM1 have rece...

  6. Immediate effects of using ankle-foot orthoses in the kinematics of gait and in the balance reactions in Charcot-Marie-Tooth disease

    OpenAIRE

    Pereira, Rouse Barbosa; Felício, Lílian Ramiro; Ferreira, Arthur de Sá; Menezes, Sara Lúcia de; Freitas, Marcos Raimundo Gomes de; Orsini, Marco

    2014-01-01

    The Charcot-Marie-Tooth (CMT) disease is a peripheral hereditary neuropathy with progressive distal muscle atrophy and weakness, mainly in lower limbs, that evolves limiting the gait and balance. The objective of the study was to analyse the immediate effects of using Ankle-Foot Orthosis (AFO) in the gait's kinematics and balance in patients with CMT. Nine individuals were evaluated by Tinetti scales and Dynamic Gait Index (DGI) and gait's kinematics parameters through the motion capturing sy...

  7. Selection of den sites by black bears in the southern Appalachians

    Science.gov (United States)

    Reynolds-Hogland, M. J.; Mitchell, M.S.; Powell, R.A.; Brown, D.C.

    2007-01-01

    We evaluated selection of den sites by American black bears (Ursus americanus) in the Pisgah Bear Sanctuary, western North Carolina, by comparing characteristics of dens at 53 den sites with availability of habitat characteristics in annual home ranges of bears and in the study area. We also tested whether den-site selection differed by sex, age, and reproductive status of bears. In addition, we evaluated whether the den component of an existing habitat model for black bears predicted where bears would select den sites. We found bears selected den sites far from gravel roads, on steep slopes, and at high elevations relative to what was available in both annual home ranges and in the study area. Den-site selection did not differ by sex or age, but it differed by reproductive status. Adult females with cubs preferred to den in areas that were relatively far from gravel roads, but adult females without cubs did not. The habitat model overestimated the value of areas near gravel roads, underestimated the value of moderately steep areas, and did not include elevation as a predictor variable. Our results highlight the importance of evaluating den selection in terms of both use and availability of den characteristics. ?? 2007 American Society of Mammalogists.

  8. Abort inom den islamiska rättstraditionen

    OpenAIRE

    Sayed, Mosa

    2013-01-01

    Den svenska patientpopulationens stora heterogenitet, exempelvis med hänsyn till etnicitet, kultur, religion och nationell härkomst, kan på olika sätt påverka hur patienter uppfattar vad som utgör god vård. Islam och muslimer utgör idag en del av det svenska samhället och representerar en beaktansvärd del av dem som vänder sig till hälso- och sjukvården. Forskning om islam och frågor rörande hälso- och sjukvård i den svenska kontexten är dock begränsad. Inte minst gäller det synen på abort in...

  9. Den græske by i Afghanistan

    DEFF Research Database (Denmark)

    Hannestad, Lise

    2016-01-01

    Byen Ai Khanoum som blev udgravet i i 1960'erne i det nordøstlige Afghanistan blev grundlagt som følge af Alexander den Stores erobring af hele Nærorienten og frem til det nordlige Indien. Fundene viser en spændende blanding af græsk og nræorientalsk kultur......Byen Ai Khanoum som blev udgravet i i 1960'erne i det nordøstlige Afghanistan blev grundlagt som følge af Alexander den Stores erobring af hele Nærorienten og frem til det nordlige Indien. Fundene viser en spændende blanding af græsk og nræorientalsk kultur...

  10. Können Statine den Knochenstoffwechsel positiv beeinflussen?

    Directory of Open Access Journals (Sweden)

    Vock L

    2005-01-01

    Full Text Available Statine, potente Inhibitoren der HMG-CoA-Reduktase, werden erfolgreich zur Senkung der Cholesterinblutspiegel eingesetzt. In den letzten Jahren sind jedoch zahlreiche andere Wirkungen der Statine aufgedeckt worden, die möglicherweise für den Knochenstoffwechsel von Bedeutung sind: In vitro konnten faszinierende knochenanabole Wirkungen der Statine bewiesen werden. Welche molekularen Mechanismen für diese Beobachtungen genau verantwortlich sind, ist nach wie vor unklar. Auch konnten in anderen In-vitro-Studien, Tiermodellen und klinischen Studien diese eindrucksvollen Resultate nicht immer bestätigt werden. Das vorliegende Bild der Statine im Knochenstoffwechsel ist uneinheitlich. Viele Fragen bleiben offen. Es fehlen neben genaueren Erkenntnissen über die Eigenschaften der einzelnen Statine auch Resultate besser auf diese Fragestellung zugeschnittener Studien.

  11. Pladebranchen - om den ændrede mediesituation i Danmark

    Directory of Open Access Journals (Sweden)

    Poul Martin Bonde

    1992-08-01

    Full Text Available Lanceringen af nye plader i radio og TV er afgørende elementer i mar- kedsføringen. Den danske pladebranche var sen til at udnytte de nye muligheder som åbnede sig med lokalradioerne i 1983 - men i dag giver en kombination af henved 50 store lokalradioer og tre TV-kanaler (DR, TV2 og TV3 samt i mindre omfang satellitkanalerne, helt nye muligheder for at få nye musiknavne frem i publikums øre- og øjenhøjde. Det har givet uoverskuelighed med indtil videre også en ny alsidighed og vitalitet i pladeproduktionen i Danmark. Både med hensyn til de unges rock og den bredere folkelighed med Jodle Birge osv.. Poul Martin Bonde er free-lance musikkonsulent og -skribent og rapporterer her fra er sted midt mellem publikum og dansk medie- og musikindustri.

  12. As contribuições de Charcot e de Marsden para o desenvolvimento dos distúrbios do movimento nos séculos XIX e XX

    Directory of Open Access Journals (Sweden)

    Teive Hélio A.G.

    2001-01-01

    Full Text Available Charcot contribuiu significativamente no século XIX na descrição de várias enfermidades neurológicas, em particular na área dos distúrbios do movimento. Charcot contribuiu de forma exponencial na descrição clínica minuciosa da doença de Parkinson, além de introduzir o primeiro tratamento farmacológico. Na área das hipercinesias realizou estudos sobre a síndrome de Tourette, o diagnóstico diferencial dos tremores, das coréias e o estudo inicial sobre startle. Marsden, recentemente falecido, destacou-se no século XX com inúmeras publicações na área dos movimentos anormais.São contribuições seminais os estudos sobre a doença de Parkinson, distonias, mioclonias , tremor essencial, a descrição das síndromes " Painful Legs Moving Toes ", "Gait Ignition Failure" e o "Tremor Primário da Escrita". As contribuições de Charcot no século XIX e de Marsden no século XX na área dos distúrbios do movimento permitem concluir que ambos foram as figuras mais representativas desta área nos últimos dois séculos.

  13. Major destructive asymptomatic lumbar Charcot lesion treated with three column resection and short segment reconstruction. Case report, treatment strategy and review of literature.

    Science.gov (United States)

    Valancius, Kestutis; Garg, Gaurav; Duicu, Madalina; Hansen, Ebbe Stender; Bunger, Cody

    2017-01-01

    Charcot's spine is a long-term complication of spinal cord injury. The lesion is often localized at the caudal end of long fusion constructs and distal to the level of paraplegia. However, cases are rare and the literature relevant to the management of Charcot's arthropathy is limited. This paper reviews the clinical features, diagnosis, and surgical management of post-traumatic spinal neuroarthropathy in the current literature. We present a rare case of adjacent level Charcot's lesion of the lumbar spine in a paraplegic patient, primarily treated for traumatic spinal cord lesion 39 years before current surgery. We have performed end-to-end apposition of bone after 3 column resection of the lesion, 3D correction of the deformity, and posterior instrumentation using a four-rod construct. Although the natural course of the disease remains unclear, surgery is always favorable and remains the primary treatment modality. Posterior long-segment spinal fusion with a four-rod construct is the mainstay of treatment to prevent further morbidity. Our technique eliminated the need for more extensive anterior surgery while preserving distal motion. © The Authors, published by EDP Sciences, 2017.

  14. Major destructive asymptomatic lumbar Charcot lesion treated with three column resection and short segment reconstruction. Case report, treatment strategy and review of literature

    Directory of Open Access Journals (Sweden)

    Valancius Kestutis

    2017-01-01

    Full Text Available Charcot's spine is a long-term complication of spinal cord injury. The lesion is often localized at the caudal end of long fusion constructs and distal to the level of paraplegia. However, cases are rare and the literature relevant to the management of Charcot's arthropathy is limited. This paper reviews the clinical features, diagnosis, and surgical management of post-traumatic spinal neuroarthropathy in the current literature. We present a rare case of adjacent level Charcot's lesion of the lumbar spine in a paraplegic patient, primarily treated for traumatic spinal cord lesion 39 years before current surgery. We have performed end-to-end apposition of bone after 3 column resection of the lesion, 3D correction of the deformity, and posterior instrumentation using a four-rod construct. Although the natural course of the disease remains unclear, surgery is always favorable and remains the primary treatment modality. Posterior long-segment spinal fusion with a four-rod construct is the mainstay of treatment to prevent further morbidity. Our technique eliminated the need for more extensive anterior surgery while preserving distal motion

  15. The central nervous system phenotype of X-linked Charcot-Marie-Tooth disease: a transient disorder of children and young adults.

    Science.gov (United States)

    Al-Mateen, Majeed; Craig, Alexa Kanwit; Chance, Phillip F

    2014-03-01

    We describe 2 patients with X-linked Charcot-Marie-Tooth disease, type 1 (CMTX1) disease and central nervous system manifestations and review 19 cases from the literature. Our first case had not been previously diagnosed with Charcot-Marie-Tooth disease, and the second case, although known to have Charcot-Marie-Tooth disease, was suspected of having CMTX1 after presentation with central nervous system manifestations. The most common central nervous system manifestations were transient and included dysarthria, ataxia, hemiparesis, and tetraparesis resembling periodic paralysis. Of the 21 patients, 19 presented at 21 years of age or younger, implicating CMTX1 with transient central nervous system manifestations as a disorder that predominantly affects children and adolescents. CMTX1 should be included in the differential diagnosis of patients who present with transient central nervous system phenomena, including stroke-like episodes, tetraparesis suggestive of periodic paralysis, dysarthria, ataxia, or combinations of these deficits. Reversible, bilateral, nonenhancing white matter lesions and restricted diffusion on magnetic resonance imaging are characteristic features of the central nervous system phenotype of CMTX1.

  16. Farvel til den privatpraktiserende lærer?

    DEFF Research Database (Denmark)

    Heilesen, Simon; Nielsen, Jørgen Lerche

    2005-01-01

    Artiklens forfattere fremlægger nogle bud på, hvorledes undervisere vil kunne engagere sig i gensidigt understøttende samarbejde, når de benytter samarbejds- og e-læringssystemer. Det forudsætter, at vi er parate til at revidere den traditionelle position, hvor vi som lærere alene og isoleret stå...

  17. Den Pædagogiske Refleksionsmodel som sammenhængskraft

    DEFF Research Database (Denmark)

    Voergaard Poulsen, Bettina; Lucht, Camill; Vibholm Persson, Stine

    Den Pædagogiske Refleksions Model (PRM) illustrerer de vidensdimensioner, der indgår i en kvalificeret klinisk beslutning. I projektet 'Sammenhæng på TVÆRS i fremtidens sygeplejeuddannelse (PÅ TVÆRS)" indgår PRM som pædagogisk greb. Der undersøges om PRM skaber sammenhæng for studerendes læring i...

  18. Den enkeltes livsmuligheder i fællesskaber

    DEFF Research Database (Denmark)

    Schwartz, Ida

    2012-01-01

    for selvbestemmelse og individuelle valg, har i nogen grad skygget for en opmærksomhed på, at mennesker alment betragtet er afhængige af at være en del af sociale fællesskaber (Engen, 2009). Artiklen bygger på den grundantagelse, at vi alle realiserer det gode liv for os selv gennem vores deltagelse i sociale...

  19. Den fjerde vej: Trumps sejr skaber ny samfundsorden

    DEFF Research Database (Denmark)

    Rasmussen, Martin Møller Boje; Andersen, Torben K.; Kragh, Claus

    2016-01-01

    Bag Donald Trumps uempatiske retorik gemmer sig omridset af et politisk projekt, man kan kalde den fjerde vej. USA’s kommende præsident blander højre- og venstreorienterede mærkesager til et nyt nationalsocialt politisk koncept. Spørgsmålet er, om Trumps fjerde vej er et seriøst bud på en ny...

  20. Digital kommunikation med den offentlige sektor: Styrelser og statslige institutioner

    DEFF Research Database (Denmark)

    Berger, Jesper Bull; Andersen, Kim Normann

    Denne rapport sammenfatter hovedresultaterne for styrelser og statslige organisationer af en undersøgelse gennemført i sommeren 2013 om besvarelse af e-mail og digital post i den statslige, regionale og kommunale sektor. Allerede med eDag3 1. nov. 2010 skulle alle myndigheder have oprettet en...... digital postkasse, som borgerne kunne skrive til. I denne undersøgelse sættes der fokus på myndighedernes besvarelse af den digitale post. Digital post blev bl.a. etableret som et alternativ til almindelig e-mail for at det offentlige kan kommunikere med borgere og virksomheder på en sikker måde, dvs....... uden at uvedkommende kan få adgang til følsomme oplysninger. Fokus for undersøgelsen er hvordan håndterer myndighederne besvarelserne i den digitale postkasse: svarer de på digital post og e-mail, hvor hurtigt svarer de og er svarene brugbare? Vi har også undersøgt besvarelse af e-mail, dels...

  1. Den visuelle oplevelses økonomi – klassisk, neoklassisk, relationel

    DEFF Research Database (Denmark)

    Michelsen, Anders Ib

    2009-01-01

    Det foreliggende kapitel søger kortfattet at skitsere en relation mellem visuel kultur og økonomi, som i videre forstand er et konkret input til en mulig teori om vi- suel kulturøkonomi. Med udgangspunkt i en sammenstilling af Johann P. Arnasons teori om en ”kulturel artikulation af verden” med P...... kulturøkonomi, der går ud over den traditionelle diskrepans mel- lem kulturbegreber, fx af antropologisk art, og økonomibegreber, fx af neoklassisk art....

  2. Den universelle velfærdsstat er under pres

    DEFF Research Database (Denmark)

    Villadsen, Kaspar

    2016-01-01

    Hvordan kan man hjælpe uden at ødelægge selv-ansvaret? Hvilke krav skal der være for at få hjælp? Og hvad er skadevirkningerne af en generøs og let opnåelig hjælp? Mange af de spørgsmål, der præger dagens debat, gjorde sig også gældende, da den universelle velfærdsstat dukkede op i starten af 1900...

  3. EU's tiltræden til EMRK - et sisyfosarbejde?

    DEFF Research Database (Denmark)

    Bang Fuglsang Madsen Sørensen, Henning

    2015-01-01

    EU-Domstolen afviste med opinion 2/13 den 18. december 2014 at lade EU tiltræde EMRK på grundlag af et udkast til en tiltrædelsesaftale. I artiklen behandles baggrunden for og det konkrete indhold i EU-Domstolens afvisning, hvorefter det undersøges, i hvilket omfang EMD fremover kan forventes...... at respektere EU-rettens forrang og dermed undlade at holde medlemsstaterne ansvarlige for påståede krænkelser som følge af medlemsstaternes forpligtelser efter EU-retten....

  4. Deletion of P2 promoter of GJB1 gene a cause of Charcot-Marie-Tooth disease.

    Science.gov (United States)

    Kulshrestha, R; Burton-Jones, S; Antoniadi, T; Rogers, M; Jaunmuktane, Z; Brandner, S; Kiely, N; Manuel, R; Willis, T

    2017-08-01

    X-linked Charcot-Marie-Tooth disease (CMT) is the second most common cause of CMT, and is usually caused by mutations in the gap junction protein beta 1 (GJB1) gene. This gene has nerve specific P2 promoter that work synergistically with SOX10 and EGR2 genes to initiate transcription. Mutation in this region is known to cause Schwann cell dysfunction. A single large family of X linked peripheral neuropathy was identified in our practice. Next generation sequencing for targeted panel assay identified an upstream exon-splicing deletion identified extending from nucleotide c.-5413 to approximately - c.-49. This matches the sequence of 32 nucleotides at positions c.*218-*249 in the 3'UTR downstream of the GJB1 gene. The deleted fragment included the entire P2 promoter region. The deletion segregated with the disease. To our knowledge a deletion of the P2 promoter alone as a cause of CMT has not been reported previously. Copyright © 2017 Elsevier B.V. All rights reserved.

  5. Rapid Identification of Pathogenic Variants in Two Cases of Charcot-Marie-Tooth Disease by Gene-Panel Sequencing

    Directory of Open Access Journals (Sweden)

    Chi-Chun Ho

    2017-04-01

    Full Text Available Charcot-Marie-Tooth disease (CMT is a common inherited peripheral neuropathy affecting up to 1 in 1214 of the general population with more than 60 nuclear genes implicated in its pathogenesis. Traditional molecular diagnostic pathways based on relative prevalence and clinical phenotyping are limited by long turnaround time, population-specific prevalence of causative variants and inability to assess multiple co-existing variants. In this study, a CMT gene panel comprising 27 genes was used to uncover the pathogenic mutations in two index patients. The first patient is a 15-year-old boy, born of consanguineous parents, who has had frequent trips and falls since infancy, and was later found to have inverted champagne bottle appearance of bilateral legs and foot drop. His elder sister is similarly affected. The second patient is a 37-year-old woman referred for pre-pregnancy genetic diagnosis. During early adulthood, she developed progressive lower limb weakness, difficulties in tip-toe walking and thinning of calf muscles. Both patients are clinically compatible with CMT, have undergone multiple genetic testings and have not previously received a definitive genetic diagnosis. Patients 1 and 2 were found to have pathogenic homozygous HSPB1:NM_001540:c.250G>A (p.G84R variant and heterozygous GDAP1:NM_018972:c.358C>T (p.R120W variant, respectively. Advantages and limitations of the current approach are discussed.

  6. Modeling the Pathogenesis of Charcot-Marie-Tooth Disease Type 1A Using Patient-Specific iPSCs

    Directory of Open Access Journals (Sweden)

    Lei Shi

    2018-01-01

    Full Text Available Charcot-Marie-Tooth disease type 1A (CMT1A, one of the most frequent inherited peripheral neuropathies, is associated with PMP22 gene duplication. Previous studies of CMT1A mainly relied on rodent models, and it is not yet clear how PMP22 overexpression leads to the phenotype in patients. Here, we generated the human induced pluripotent stem cell (hiPSC lines from two CMT1A patients as an in vitro cell model. We found that, unlike the normal control cells, CMT1A hiPSCs rarely generated Schwann cells through neural crest stem cells (NCSCs. Instead, CMT1A NCSCs produced numerous endoneurial fibroblast-like cells in the Schwann cell differentiation system, and similar results were obtained in a PMP22-overexpressing iPSC model. Therefore, despite the demyelination-remyelination and/or dysmyelination theory for CMT1A pathogenesis, developmental disabilities of Schwann cells may be considered as an underlying cause of CMT1A. Our results may have important implications for the uncovering of the underlying mechanism and the development of a promising therapeutic strategy for CMT1A neuropathy.

  7. Different nerve ultrasound patterns in charcot-marie-tooth types and hereditary neuropathy with liability to pressure palsies.

    Science.gov (United States)

    Padua, Luca; Coraci, Daniele; Lucchetta, Marta; Paolasso, Ilaria; Pazzaglia, Costanza; Granata, Giuseppe; Cacciavillani, Mario; Luigetti, Marco; Manganelli, Fiore; Pisciotta, Chiara; Piscosquito, Giuseppe; Pareyson, Davide; Briani, Chiara

    2018-01-01

    Nerve ultrasound in Charcot-Marie-Tooth (CMT) disease has focused mostly on the upper limbs. We performed an evaluation of a large cohort of CMT patients in which we sonographically characterized nerve abnormalities in different disease types, ages, and nerves. Seventy patients affected by different CMT types and hereditary neuropathy with liability to pressure palsies (HNPP) were evaluated, assessing median, ulnar, fibular, tibial, and sural nerves bilaterally. Data were correlated with age. Nerve dimensions were correlated with CMT type, age, and nerve site. Nerves were larger in demyelinating than in axonal neuropathies. Nerve involvement was symmetric. CMT1 patients had larger nerves than did patients with other CMT types. Patients with HNPP showed enlargement at entrapment sites. Our study confirms the general symmetry of ultrasound nerve patterns in CMT. When compared with ultrasound studies of nerves of the upper limbs, evaluation of the lower limbs did not provide additional information. Muscle Nerve 57: E18-E23, 2018. © 2017 Wiley Periodicals, Inc.

  8. MDCT assessment of CAD in type-2 diabetic subjects with diabetic neuropathy: the role of Charcot neuro-arthropathy

    International Nuclear Information System (INIS)

    Marano, Riccardo; Savino, Giancarlo; Merlino, Biagio; Pirro, Federica; Rutigliano, Claudia; Santangelo, Carolina; Minoiu, Aurelian Costin; Natale, Luigi; Bonomo, Lorenzo; Pitocco, Dario; Di Stasio, Enrico; Trani, Carlo

    2016-01-01

    To compare the CACS and CAD severity assessed by MDCT in neuropathic type-2 diabetic patients with and without Charcot-neuroarthropathy (CN). Thirty-four CN asymptomatic-patients and 36 asymptomatic-patients with diabetic-neuropathy (DN) without CN underwent MDCT to assess CACS and severity of CAD. Patients were classified as positive for significant CAD in presence of at least one stenosis >50 % on MDCT-coronary-angiography (MDCT-CA). Groups were matched for age, sex and traditional CAD risk-factors. The coronary-angiography (CA) was performed in all patients with at least a significant stenosis detected by MDCT-CA, both as reference and eventually as treatment. CN patients showed higher rates of significant CAD in comparison with DN subjects [p < 0.001], while non-significant differences were observed in CACS (p = 0.980). No significant differences were also observed in CACS distribution in all subjects for stenosis ≥/<50 % (p = 0.814), as well as in both groups (p = 0.661 and 0.559, respectively). The MDCT-CA showed an overall diagnostic-accuracy for significant CAD of 87 %. These preliminary data suggest that CN-patients have a higher prevalence of severe CAD in comparison with DN-patients, while coronary plaques do not exhibit an increased amount of calcium. MDCT may be helpful to assess the CV risk in such asymptomatic type-2-diabetic patients with autonomic-neuropathy. (orig.)

  9. Laryngeal neuropathy of Charcot-Marie-Tooth disease: further observations and novel mutations associated with vocal fold paresis.

    Science.gov (United States)

    Benson, Brian; Sulica, Lucian; Guss, Joel; Blitzer, Andrew

    2010-02-01

    To describe and define laryngeal neuropathy in Charcot-Marie-Tooth (CMT) disease. Retrospective record review from a university laryngology practice. Four adult CMT patients presented with laryngeal symptoms. Three patients exhibited bilateral vocal fold palsy, in each case with more severe hypomobility on the left. One case exhibited an isolated left vocal fold palsy. All patients complained of hoarseness and stridor, three had dyspnea, two patients had dysphagia, and one had obstructive sleep apnea (OSA). One patient has required airway surgery to date. Genetic testing revealed known sequence alterations in one case and sequence alterations previously not associated with laryngeal dysfunction in two cases. One case was familial and two were sporadic; information is not available in a fourth. The clinical course of the cases suggests slowly progressive neuropathy that appears to be nerve length dependent. The lack of severe respiratory distress despite dense bilateral paresis is consistent with existing reports and with the reported low rate of tracheostomy in adults with laryngeal manifestations of CMT. Genetic testing does not currently inform expectations or management of laryngeal disease. Dyspnea, dysphagia, and OSA symptoms in patients with CMT require careful laryngologic evaluation.

  10. Unraveling the genetic landscape of autosomal recessive Charcot-Marie-Tooth neuropathies using a homozygosity mapping approach

    Science.gov (United States)

    Zimoń, Magdalena; Battaloǧlu, Esra; Parman, Yesim; Erdem, Sevim; Baets, Jonathan; De Vriendt, Els; Atkinson, Derek; Almeida-Souza, Leonardo; Deconinck, Tine; Ozes, Burcak; Goossens, Dirk; Cirak, Sebahattin; Van Damme, Philip; Shboul, Mohammad; Voit, Thomas; Van Maldergem, Lionel; Dan, Bernard; El-Khateeb, Mohammed S.; Guergueltcheva, Velina; Lopez-Laso, Eduardo; Goemans, Nathalie; Masri, Amira; Züchner, Stephan; Timmerman, Vincent; Topaloǧlu, Haluk; De Jonghe, Peter

    2016-01-01

    Autosomal recessive forms of Charcot-Marie-Tooth disease (ARCMT) are rare but severe disorders of the peripheral nervous system. Their molecular basis is poorly understood due to the extensive genetic and clinical heterogeneity, posing considerable challenges for patients, physicians, and researchers. We report on the genetic findings from a systematic study of a large collection of 174 independent ARCMT families. Initial sequencing of the three most common ARCMT genes (ganglioside-induced differentiation protein 1—GDAP1, SH3 domain and tetratricopeptide repeats-containing protein 2—SH3TC2, histidine-triad nucleotide binding protein 1—HINT1) identified pathogenic mutations in 41 patients. Subsequently, 87 selected nuclear families underwent single nucleotide polymorphism (SNP) genotyping and homozygosity mapping, followed by targeted screening of known ARCMT genes. This strategy provided molecular diagnosis to 22 % of the families. Altogether, our unbiased genetic approach identified pathogenic mutations in ten ARCMT genes in a total of 41.3 % patients. Apart from a newly described founder mutation in GDAP1, the majority of variants constitute private molecular defects. Since the gene testing was independent of the clinical phenotype of the patients, we identified mutations in patients with unusual or additional clinical features, extending the phenotypic spectrum of the SH3TC2 gene. Our study provides an overview of the ARCMT genetic landscape and proposes guidelines for tackling the genetic heterogeneity of this group of hereditary neuropathies. PMID:25231362

  11. MARS variant associated with both recessive interstitial lung and liver disease and dominant Charcot-Marie-Tooth disease.

    Science.gov (United States)

    Rips, Jonathan; Meyer-Schuman, Rebecca; Breuer, Oded; Tsabari, Reuven; Shaag, Avraham; Revel-Vilk, Shoshana; Reif, Shimon; Elpeleg, Orly; Antonellis, Anthony; Harel, Tamar

    2018-04-12

    Aminoacyl-tRNA synthetases (ARSs) are ubiquitously expressed enzymes responsible for charging tRNA with cognate amino acids during protein translation. Non-canonical functions are increasingly recognized, and include transcription and translation control and extracellular signaling. Monoallelic mutations in genes encoding several ARSs have been identified in axonal Charcot-Marie-Tooth (CMT2) disease, whereas biallelic mutations in ARS loci have been associated with multi-tissue syndromes, variably involving the central nervous system, lung, and liver. We report a male infant of non-consanguineous origin, presenting with successive onset of transfusion-dependent anemia, hypothyroidism, cholestasis, interstitial lung disease, and developmental delay. Whole-exome sequencing (WES) revealed compound heterozygosity for two variants (p.Tyr307Cys and p.Arg618Cys) in MARS, encoding methionyl-tRNA synthetase. Biallelic MARS mutations are associated with interstitial lung and liver disease (ILLD). Interestingly, the p.Arg618Cys variant, inherited from an unaffected father, was previously reported in a family with autosomal dominant late-onset CMT2. Yeast complementation assays confirmed pathogenicity of p.Arg618Cys, yet suggested retained function of p.Tyr307Cys. Our findings underscore the phenotypic variability associated with ARS mutations, and suggest genetic or environmental modifying factors in the onset of monoallelic MARS-associated CMT2. Copyright © 2018 Elsevier Masson SAS. All rights reserved.

  12. Is the Charcot and Bernard case (1883) of loss of visual imagery really based on neurological impairment?

    Science.gov (United States)

    Zago, Stefano; Allegri, Nicola; Cristoffanini, Marta; Ferrucci, Roberta; Porta, Mauro; Priori, Alberto

    2011-11-01

    INTRODUCTION. The Charcot and Bernard case of visual imagery, Monsieur X, is a classic case in the history of neuropsychology. Published in 1883, it has been considered the first case of visual imagery loss due to brain injury. Also in recent times a neurological valence has been given to it. However, the presence of analogous cases of loss of visual imagery in the psychiatric field have led us to hypothesise functional origins rather than organic. METHODS. In order to assess the validity of such an inference, we have compared the symptomatology of Monsieur X with that found in cases of loss of visual mental images, both psychiatric and neurological, presented in literature. RESULTS. The clinical findings show strong assonances of the Monsieur X case with the symptoms manifested over time by the patients with functionally based loss of visual imagery. CONCLUSION. Although Monsieur X's damage was initially interpreted as neurological, reports of similar symptoms in the psychiatric field lead us to postulate a functional cause for his impairment as well.

  13. MDCT assessment of CAD in type-2 diabetic subjects with diabetic neuropathy: the role of Charcot neuro-arthropathy

    Energy Technology Data Exchange (ETDEWEB)

    Marano, Riccardo; Savino, Giancarlo; Merlino, Biagio; Pirro, Federica; Rutigliano, Claudia; Santangelo, Carolina; Minoiu, Aurelian Costin; Natale, Luigi; Bonomo, Lorenzo [Catholic University of Rome, ' ' A. Gemelli' ' University Hospital, Department of Radiological Sciences - Institute of Radiology, Rome (Italy); Pitocco, Dario [Catholic University of Rome, ' ' A. Gemelli' ' University Hospital, Department of Internal Medicine, Rome (Italy); Di Stasio, Enrico [Catholic University of Rome, ' ' A. Gemelli' ' University Hospital, Department of Clinical Biochemistry, Rome (Italy); Trani, Carlo [Catholic University of Rome, ' ' A. Gemelli' ' University Hospital, Department of Cardiovascular Medicine - Institute of Cardiology, Rome (Italy)

    2016-03-15

    To compare the CACS and CAD severity assessed by MDCT in neuropathic type-2 diabetic patients with and without Charcot-neuroarthropathy (CN). Thirty-four CN asymptomatic-patients and 36 asymptomatic-patients with diabetic-neuropathy (DN) without CN underwent MDCT to assess CACS and severity of CAD. Patients were classified as positive for significant CAD in presence of at least one stenosis >50 % on MDCT-coronary-angiography (MDCT-CA). Groups were matched for age, sex and traditional CAD risk-factors. The coronary-angiography (CA) was performed in all patients with at least a significant stenosis detected by MDCT-CA, both as reference and eventually as treatment. CN patients showed higher rates of significant CAD in comparison with DN subjects [p < 0.001], while non-significant differences were observed in CACS (p = 0.980). No significant differences were also observed in CACS distribution in all subjects for stenosis ≥/<50 % (p = 0.814), as well as in both groups (p = 0.661 and 0.559, respectively). The MDCT-CA showed an overall diagnostic-accuracy for significant CAD of 87 %. These preliminary data suggest that CN-patients have a higher prevalence of severe CAD in comparison with DN-patients, while coronary plaques do not exhibit an increased amount of calcium. MDCT may be helpful to assess the CV risk in such asymptomatic type-2-diabetic patients with autonomic-neuropathy. (orig.)

  14. Klimagasudledning i kæden fra foder- til mælkeproduktion

    DEFF Research Database (Denmark)

    Mogensen, Lisbeth; Lund, Peter; Kristensen, Troels

    2012-01-01

    Når man skal vurdere effekten af forskellige tiltag til reduktion af klimagasudledningen, f.eks. via ændret fodersammensætning, er det vigtigt at se på den samlede effekt i hele kæden. Ellers kan man mindske udledning et sted i kæden og øge udledningen et andet sted, og samlet set ikke opnå en...

  15. Verzwickte Flussgemeinschaft - Warum es so schwierig ist, den Flüssen Raum zu geben

    NARCIS (Netherlands)

    Hartmann, T.

    2011-01-01

    Extreme Hochwasser verursachen enorme Schäden in Flusslandschaften. Flussgemeinschaften müssen künftig den Flüssen mehr Raum geben, um Hochwasser in der Fläche zurückzuhalten, statt in der Höhe (der Deiche) zu bekämpfen. Die Idee „den Flüssen mehr Raum geben“ beschreibt eigentlich etwas

  16. Ueber den begriff "Kinoplasma" in der spermiogenese von Australorbis Glabratus Olivaceus (Mollusca, Pulmonata, Planorbidae

    Directory of Open Access Journals (Sweden)

    Rudolf Barth

    1960-11-01

    Full Text Available Zur Klaerung der Frage, ob der Begriff "Kinoplasma" fuer gewisse, von MERTON (1924,1926, 1930 beobachtete Bildungen an den reifenden Spermiden von pulmonaten Mollusken oder fuer Bestandteile des Cytoplasmas im Sinne von STRASBURGER und SCARTH zu verwenden ist, werden in der vorliegenden Mitteilung die Vorgaenge bei der Spermiohistogenese von Australorbis glabratus olivaceus untersucht. Es ergibt sich: 1. Das von MERTON bezeichnete "Kinoplasma" existiert nicht als solches, es handelt sich bei den von ihm dargestellten Protoplasmabildungen um kugelige, von den Spermiden abgeschnuerte Restkoerper nicht verwendeten Baumaterials, bestehend aus Protoplasma und einigen Mitochondrien. Sie werden von den Naehr- oder Bazalzellen phagozytiert. Der Ausdruck "Kinoplasma" kann nur fuer die submikroskopischen, geformten, faedigen Elemente des Cytoplasmas reserviert bleiben, die den geradlinigen Fall der uebrigen nicht geformten Komponenten bremst oder ablenkt; damit muss das Kinoplasma aber aus dem Begriff des Cytoplasmas herausgenommen werden, da es, wenn auch vermutlich reversibel, eine Differenzierung darstellt. 2. Der Spermienfaden wird von den Centriolen (Axialfilament und den Mitochondrien (zwei peripher gelegene Spiralfilamente, sowie einem Plasmamantel gebildet. 3. Nach Beendigung des Auswachsens der Spermiengeissel, die zu diesem Zeitpunkt nur aus dem Achsenfaden und dem Protoplasmazylinder besteht, setzt sich eine Protoplasmamasse vom Kopf in Richtung zum Geisselende in Bewegung. Sie fuehrt den Golgi-Koerper und sehr viele Mitochondrien mit sich. Aus diesen entwickeln sich Fibrillen, die sich zu den beiden Spiralfilamenten zusammenfuegen. Diese Masse entspricht der von MERTON in seiner Theorie als Kinoplasma bezeichneten Komponente. 4. Die Bewegung dieses Protoplasmateils wird auf den Schub zurueckgefuehrt, den die sich bildenden Fibrillen auf die Mitochondrien ausueben. 5. Die Rueckwaertsbewegung dieses Protoplasmakoerpers beruht wahrscheinlich auf

  17. Den ecology of Octopus vulgaris Cuvier, 1797, on soft sediment: availability and types of shelter

    Directory of Open Access Journals (Sweden)

    Stelios Katsanevakis

    2004-03-01

    Full Text Available To avoid predation, octopuses select and actively modify shelters (also called dens in the substratum, where they remain most of the time, especially during daylight hours. The main questions that this study deals with are: Is den availability a significant constraint for the distribution of Octopus vulgaris on soft sediment? What kind of dens does O. vulgaris use on soft sediment and what factors affect the selection of one type instead of another? With population density measurements by SCUBA diving and enrichment experiments with artificial dens, we concluded that the availability of solid materials necessary for den construction is a limiting factor for the distribution of O. vulgaris on soft sediment. O. vulgaris used four different types of den on soft sediment: well (a vertical hole in the sediment, rock/stone (the octopus uses a rock or a large stone to dig a cavity under it, shell (an empty shell is used, human origin (a solid material of human origin is used. The relative proportion of the four types of den in the areas studied was: 38.7% human origin, 29.7% well, 21.5% rock/stone, 2.9% shell. Also, 7.3% of the octopuses were found outside their den. The main types of den were found in different relative proportions in relation to the depth, the distance from shore, the octopus size and the granulometry of the sediment.

  18. Videnskabsteorien og den reflekterende dømmekraft

    DEFF Research Database (Denmark)

    Jørgensen, Klaus Frovin

    2007-01-01

    I denne artikel diskuterer jeg Immanuel Kants videnskabssyn, som det tager sig ud i Kritik af dømmekraften. Udgangspunktet er erkendelsesteorien og i særdeleshed den såkaldte skemateori. For Kant findes der rene videnskaber og empiriske videnskaber. De rene videnskabers begreber er karakteriseret...... instrumentalisme, der hersker. Der er visse subjektive principper og maximer, som er mere ’naturlige’ og ’rigtige’ end andre. Kants typiske eksempler herpå er ideen om fuldstændig enhed af den videnskabelige erkendelse og ideen om teleologi i naturen – at intet i naturen er tilfældigt, og at alt har et formål....... Artiklen afsluttes ved at perspektivere og sammenstille Kants videnskabsfilosofi med Thomas Kuhns nutidige videnskabsteori. Jeg argumenterer for, at Kants og Kuhns teorier har fundamentale elementer og strukturer til fælles, og at de vigtigste fornuftsmæssige ideer og principper hos Kant går igen i Kuhns...

  19. Der chthonische Dionysos - Zur Wirkmacht des Mythos in den Mysterien

    Directory of Open Access Journals (Sweden)

    Niklas Engel

    2016-12-01

    Full Text Available Dieser Beitrag soll aufzeigen, dass eine chthonische und eschatologische Dimension der dionysischen Göttlichkeit in verschiedenen Riten und Kulten des Gottes nachgewiesen werden kann und dabei keinesfalls mysterienexklusiv ist. Dazu soll der archäologische Befund, der Dionysos mit dem Jenseits und eschatologischen Ho nungen in Verbindung bringt, vorgestellt und untersucht werden. Darauf aufbauend soll belegt werden, dass diese jenseitige Dimension sich sowohl in Riten mit privatem Kern, hier am Beispiel der Oreibasia, als auch in Kultfeiern des ö entlichen Festkanons, wie den Anthesterien, zeigt. Abschließend soll dann Dionysos‘ Funktion in den eleusinischen Mysterien untersucht werden. This paper aims to show that a chthonic and eschatological dimension of dionysiac divinity can be found in various rites and cults of the god and that this is not exclusive for the mysteries. Recent archaeological evidence connecting Dionysos with the afterlife and eschatological expectations will be introduced and analyzed. is dimension manifests itself in rites with a private intent (e.g. the Oreibasia as well as public celebrations of the festival calendar (e.g. the Anthesteria. An analysis of Dionysos’ function in the eleusinian mysteries concludes the overview.

  20. Perge'den iki Procurator Yazıtı

    OpenAIRE

    Onur, Fatih

    2008-01-01

    Perge'den iki Procurator Yazıtı Kısa bir süre önce Aşkım Özdizbay Perge'den iki adet Latince yazıtın kopyasını ve çevirisini, Prof. Dr. Haluk Abbasoğlu için hazırladıkları armağan kitabında yayımlamıştır. Verdiği bilgilere göre, bu yazıtlar 2004 – 2005 yılları Perge kazılarında, bir silmeli kaide üzerine sonradan yerleştirilmiş olarak ele geçmiştir. T. Claudius Plocamus'un onurlandırmalarını içeren metinler üzerine yapılan kısa bir araştırma ve sonuçlarının I.v.Perge (IK 54)�...

  1. Leadership Pipeline på rejse i den offentlige sektor

    DEFF Research Database (Denmark)

    Nielsen, Jeppe; Dahl, Kristian Aagaard

    2015-01-01

    Forestillingen om, at ledelsesopgaven varierer alt efter hvilket lederniveau, der fokuseres på, trækker spor tilbage til en række tidlige ledelsesteoretikere. I de senere år har tilgangen på ny tiltrukket sig opmærksomhed såvel i praksisfeltet som blandt forskere, nok tydeligst illustreret via ud...... hinanden, og at der i praksis ikke var én, men flere idéer om Leadership Pipeline, der rejste på tværs af felter og organisationer....... udbredelse af Leadership Pipeline modellen. Forskningslitteraturen om Leadership Pipeline er imidlertid beskeden. Med teoretisk ammunition fra ”idé på rejse” perspektivet og et multi-level case studie i den danske offentlige sektor belyser artiklen udbredelse og implementering af Leadership Pipeline. Ved...... at anvende skiftende teoretiske begreber og henholdsvis zoome-ind (organisationsniveau) og zoome-ud (feltniveau) viser artiklen, hvordan en række gensidigt forbundne teoretiserings- og translationsaktiviteter sikrede Leadership Pipeline legitimitet og fremskyndede dens udbredelse samtidig med, at forskellige...

  2. Detection of diabetic retinopathy and other microvascular complications in patients with type 1 diabetes

    DEFF Research Database (Denmark)

    Rasmussen, Malin Lundberg

    fotografering af nethinden i forhold til guldstandarden med syv sammensatte felter defineret i studiet: Early Treatment Diabetic Retinopathy Study (ETDRS) (Artikel II). Derudover har vi brugt en nyere metode til at undersøge kargeometrien i nethinden for at se om en suboptimal konfiguration i nethindens kar er......Forekomsten af type 1 diabetes er stigende og diabetisk retinopati er fortsat en af de primære årsager til nedsat syn blandt personer i den arbejdsdygtige alder. Derudover er andre mikrovaskulære komplikationer som diabetisk nefropati og neuropati blandt de primære årsager til nedsat nyrefunktion......, dialysebehandling, fodsår og amputationer. Optimal kontrol af blodsukker og blodtryk kan nedsætte risikoen for eller forsinke udviklingen af sene mikrovaskulære komplikationer. Derudover har sen debut alder og kortere varighed af diabetes vist sig at være beskyttende for udviklingen af mikrovaskulære komplikationer...

  3. Irmandade afetada pela atrofia muscular peroneal de Charcot-Marie-Tooth com possível variante do fenômeno da antecipação

    Directory of Open Access Journals (Sweden)

    Aguinaldo Gonçalves

    1977-06-01

    Full Text Available Considerando-se a peculiaridade genética da atrofia peroneal de Charcot-Marie-Tooth, é feita a descrição clínica de família com três irmãos afetados, com idade de aparecimento progressivamente antecipada, refletindo possível variante do fenômeno da antecipação, condição inusitada na literatura, não só para esta doença, mas também, de modo geral, em Genética Humana.

  4. Major destructive asymptomatic lumbar Charcot lesion treated with three column resection and short segment reconstruction. Case report, treatment strategy and review of literature

    DEFF Research Database (Denmark)

    Valancius, Kestutis; Garg, Gaurav; Duicu, Madalina

    2017-01-01

    reviews the clinical features, diagnosis, and surgical management of post-traumatic spinal neuroarthropathy in the current literature. We present a rare case of adjacent level Charcot's lesion of the lumbar spine in a paraplegic patient, primarily treated for traumatic spinal cord lesion 39 years before...... current surgery. We have performed end-to-end apposition of bone after 3 column resection of the lesion, 3D correction of the deformity, and posterior instrumentation using a four-rod construct. Although the natural course of the disease remains unclear, surgery is always favorable and remains the primary...

  5. Progression of motor axon dysfunction and ectopic Na(v)1.8 expression in a mouse model of Charcot-Marie-Tooth disease 1B

    DEFF Research Database (Denmark)

    Rosberg, Mette R.; Alvarez Herrero, Susana; Klein, Dennis

    2016-01-01

    Mice heterozygously deficient for the myelin protein P0 gene (P0+/-) develop a slowly progressing neuropathy modeling demyelinating Charcot-Marie-Tooth disease (CMT1B). The aim of the study was to investigate the long-term progression of motor dysfunction in P0+/- mice at 3, 7, 12 and 20months...... pharmacologic block of NaV1.8 in P0+/-. Mathematical modeling indicated an association of altered passive cable properties with a depolarizing shift in resting membrane potential and increase in the persistent Na(+) current in P0+/-. Our data suggest that ectopic NaV1.8 expression precipitates depolarizing...

  6. Conduction block and tonic pupils in Charcot-Marie-Tooth disease caused by a myelin protein zero p.Ile112Thr mutation.

    LENUS (Irish Health Repository)

    Murphy, Sinéad M

    2011-03-01

    We report a patient with Charcot-Marie-Tooth disease (CMT) due to the p.Ile112Thr mutation in myelin protein zero (MPZ) who presented with a patchy neuropathy with conduction block and tonic pupils. Conduction block is unusual in inherited neuropathies, while pupil abnormalities are recognised to occur in CMT especially due to MPZ mutations. This case highlights that patchy demyelinating neuropathy with conduction block may occur in p.Ile112Thr MPZ mutations. Involvement of the pupils, as in this case, may be a pointer towards a genetic rather than inflammatory cause of neuropathy.

  7. Den koreanske bølgen - En kulturvitenskapelig studie av sørkoreansk populærkultur, og hvordan den har nådd Vesten

    OpenAIRE

    Kvinge, Kristin Øyvindsdatter

    2016-01-01

    Hensikten med denne oppgaven er å se på den koreanske bølgen, som ofte refereres til som Hallyu. Den tar for seg både Hallyu som innhold og Hallyu som fenomen. Den koreanske bølgen har spredd seg hurtig i løpet av de siste 20 årene, noe som har bidratt til å gjøre Korea til en av de hurtigst økende økonomiene i den moderne tid. Denne oppgaven forsøker å se nærmere på hvordan Hallyu har nådd Vesten, med fokus på Europa og Norge. Før analysen vil oppgaven se nærmere på hv...

  8. Den Dansk-Engelske Regnskabsordbog/Danish-English Dictionary of Accounting

    DEFF Research Database (Denmark)

    Nielsen, Sandro; Mourier, Lise; Bergenholtz, Henning

    Den Dansk-Engelske Regnskabsordbog. Hver af ordbøgerne har 4.100 opslagsord og ca. 15.000 ordforbindelser. Ordbøgerne bygger primært på den gældende danske årsregnskabslov, danske regnskabsvejledninger og internationale regnskabsstandarder (IAS/IFRS)....

  9. Den lille krig i fredstid. Danske militære erfaringer i Musa Qala i 2006

    DEFF Research Database (Denmark)

    Brink Rasmussen, Jakob

    2018-01-01

    Den 1. Lette Opklaringseskadron fra Bornholms forsvar af distriktscentret Musa Qala i den afghanske Helmand-provins i eftersommeren 2006 gennemanalyseres. Det sker med det formål at klarlægge, hvordan man udnyttede læring under forberedelsen til indsættelsen samt under og efter denne. Herunder da...

  10. Habitat characteristics at den sites of the Point Arena mountain beaver (Aplodontia rufa nigra)

    Science.gov (United States)

    William J. Zielinski; John E. Hunter; Robin Hamlin; Keith M. Slauson; M. J. Mazurek

    2010-01-01

    The Point Arena mountain beaver (Aplodontia rufa nigra) is a federally listed endangered species, but has been the subject of few studies. Mountain beavers use burrows that include a single subterranean den. Foremost among the information needs for this subspecies is a description of the above-ground habitat features associated with dens. Using...

  11. Den site activity patterns of adult male and female swift foxes, Vulpes velox, in Northwestern Texas

    Science.gov (United States)

    Lemons, P.R.; Ballard, W.B.; Sullivan, R.M.; Sovada, M.A.

    2003-01-01

    Activity of Swift Foxes (Vulpes velox) at den sites was studied in northwestern Texas during pup rearing seasons in 2000 and 2001 to determine role of males in parental care. Twenty-four percent of radio-collared females with a potential to breed successfully raised pups to eight weeks of age. We intensively monitored presence and absence of male and female Swift Foxes at two den sites each year. Females were present >2.6 times more at den sites than males during the pup rearing season. Female and male Swift Foxes largely stayed at dens during diurnal hours and were active away from dens during nocturnal and crepuscular hours. Females and males spent 12.4% and 3.0% more time at dens before pups emerged, than after pups emerged, respectively. Following depredation of one male parent, the female spent 29% less time at the den site. Decrease in time spent at the den by the female following loss of her mate suggested that loss of one parent might severely impact recruitment of Swift Foxes. Our observations indicated that intense Coyote (Canis latrans) depredation may severely impact pup-rearing success as well as the parental care within Swift Fox family groups.

  12. Chlorerede opløsningsmidler i den mættede zone

    DEFF Research Database (Denmark)

    Broholm, K.

    1996-01-01

    Anmeldelse af Jensen,B.K. & Nilsson,B.: Chlorerede opløsningsmidler i den mættede zone. Miljøstyrelsen 1996, (Miljøprojekt 330)......Anmeldelse af Jensen,B.K. & Nilsson,B.: Chlorerede opløsningsmidler i den mættede zone. Miljøstyrelsen 1996, (Miljøprojekt 330)...

  13. Læringsfremmende evaluering i den lægelige videreuddannelse

    DEFF Research Database (Denmark)

    Madsen, Bjørn; Klitmøller, Anders

    2011-01-01

    Denne statusartikel omhandler evaluering af læger, og hvorledes evaluering kan anvendes som en læringsfremmende foranstaltning. Fokus i artiklen er på den formelle evaluering, som den kommer til udtryk i de kliniske vejledersamtaler. Da de fleste læger i deres karriere fungerer som vejleder, er d...

  14. PMP22 related neuropathies: Charcot-Marie-Tooth disease type 1A and Hereditary Neuropathy with liability to Pressure Palsies.

    Science.gov (United States)

    van Paassen, Barbara W; van der Kooi, Anneke J; van Spaendonck-Zwarts, Karin Y; Verhamme, Camiel; Baas, Frank; de Visser, Marianne

    2014-03-19

    PMP22 related neuropathies comprise (1) PMP22 duplications leading to Charcot-Marie-Tooth disease type 1A (CMT1A), (2) PMP22 deletions, leading to Hereditary Neuropathy with liability to Pressure Palsies (HNPP), and (3) PMP22 point mutations, causing both phenotypes. Overall prevalence of CMT is usually reported as 1:2,500, epidemiological studies show that 20-64% of CMT patients carry the PMP22 duplication. The prevalence of HNPP is not well known. CMT1A usually presents in the first two decades with difficulty walking or running. Distal symmetrical muscle weakness and wasting and sensory loss is present, legs more frequently and more severely affected than arms. HNPP typically leads to episodic, painless, recurrent, focal motor and sensory peripheral neuropathy, preceded by minor compression on the affected nerve. Electrophysiological evaluation is needed to determine whether the polyneuropathy is demyelinating. Sonography of the nerves can be useful. Diagnosis is confirmed by finding respectively a PMP22 duplication, deletion or point mutation. Differential diagnosis includes other inherited neuropathies, and acquired polyneuropathies. The mode of inheritance is autosomal dominant and de novo mutations occur. Offspring of patients have a chance of 50% to inherit the mutation from their affected parent. Prenatal testing is possible; requests for prenatal testing are not common. Treatment is currently symptomatic and may include management by a rehabilitation physician, physiotherapist, occupational therapist and orthopaedic surgeon. Adult CMT1A patients show slow clinical progression of disease, which seems to reflect a process of normal ageing. Life expectancy is normal.

  15. Electromyographic and biomechanical analysis of step negotiation in Charcot Marie Tooth subjects whose level walk is not impaired.

    Science.gov (United States)

    Lencioni, Tiziana; Piscosquito, Giuseppe; Rabuffetti, Marco; Sipio, Enrica Di; Diverio, Manuela; Moroni, Isabella; Padua, Luca; Pagliano, Emanuela; Schenone, Angelo; Pareyson, Davide; Ferrarin, Maurizio

    2018-05-01

    Charcot-Marie-Tooth (CMT) is a slowly progressive disease characterized by muscular weakness and wasting with a length-dependent pattern. Mildly affected CMT subjects showed slight alteration of walking compared to healthy subjects (HS). To investigate the biomechanics of step negotiation, a task that requires greater muscle strength and balance control compared to level walking, in CMT subjects without primary locomotor deficits (foot drop and push off deficit) during walking. We collected data (kinematic, kinetic, and surface electromyographic) during walking on level ground and step negotiation, from 98 CMT subjects with mild-to-moderate impairment. Twenty-one CMT subjects (CMT-NLW, normal-like-walkers) were selected for analysis, as they showed values of normalized ROM during swing and produced work at push-off at ankle joint comparable to those of 31 HS. Step negotiation tasks consisted in climbing and descending a two-step stair. Only the first step provided the ground reaction force data. To assess muscle activity, each EMG profile was integrated over 100% of task duration and the activation percentage was computed in four phases that constitute the step negotiation tasks. In both tasks, CMT-NLW showed distal muscle hypoactivation. In addition, during step-ascending CMT-NLW subjects had relevant lower activities of vastus medialis and rectus femoris than HS in weight-acceptance, and, on the opposite, a greater activation as compared to HS in forward-continuance. During step-descending, CMT-NLW showed a reduced activity of tibialis anterior during controlled-lowering phase. Step negotiation revealed adaptive motor strategies related to muscle weakness due to disease in CMT subjects without any clinically apparent locomotor deficit during level walking. In addition, this study provided results useful for tailored rehabilitation of CMT patients. Copyright © 2018 Elsevier B.V. All rights reserved.

  16. Mild functional differences of dynamin 2 mutations associated to centronuclear myopathy and Charcot-Marie Tooth peripheral neuropathy.

    Directory of Open Access Journals (Sweden)

    Olga S Koutsopoulos

    Full Text Available The large GTPase dynamin 2 is a key player in membrane and cytoskeletal dynamics mutated in centronuclear myopathy (CNM and Charcot-Marie Tooth (CMT neuropathy, two discrete dominant neuromuscular disorders affecting skeletal muscle and peripheral nerves respectively. The molecular basis for the tissue-specific phenotypes observed and the physiopathological mechanisms linked to dynamin 2 mutations are not well established. In this study, we have analyzed the impact of CNM and CMT implicated dynamin 2 mutants using ectopic expression of four CNM and two CMT mutations, and patient fibroblasts harboring two dynamin 2 CNM mutations in established cellular processes of dynamin 2 action. Wild type and CMT mutants were seen in association with microtubules whereas CNM mutants lacked microtubules association and did not disrupt interphase microtubules dynamics. Most dynamin 2 mutants partially decreased clathrin-mediated endocytosis when ectopically expressed in cultured cells; however, experiments in patient fibroblasts suggested that endocytosis is overall not defective. Furthermore, CNM mutants were seen in association with enlarged clathrin stained structures whereas the CMT mutant constructs were associated with clathrin structures that appeared clustered, similar to the structures observed in Dnm1 and Dnm2 double knock-out cells. Other roles of dynamin 2 including its interaction with BIN1 (amphiphysin 2, and its function in Golgi maintenance and centrosome cohesion were not significantly altered. Taken together, these mild functional defects are suggestive of differences between CMT and CNM disease-causing dynamin 2 mutants and suggest that a slight impairment in clathrin-mediated pathways may accumulate over time to foster the respective human diseases.

  17. Hypoxia causes IL-8 secretion, Charcot Leyden crystal formation, and suppression of corticosteroid-induced apoptosis in human eosinophils.

    Science.gov (United States)

    Porter, L M; Cowburn, A S; Farahi, N; Deighton, J; Farrow, S N; Fiddler, C A; Juss, J K; Condliffe, A M; Chilvers, E R

    2017-06-01

    Inflamed environments are typically hypercellular, rich in pro-inflammatory cytokines, and profoundly hypoxic. While the effects of hypoxia on neutrophil longevity and function have been widely studied, little is known about the consequences of this stimulus on eosinophils. We sought to investigate the effects of hypoxia on several key aspects of eosinophil biology, namely secretion, survival, and their sensitivity to glucocorticosteroids (GCS), agents that normally induce eosinophil apoptosis. Eosinophils derived from patients with asthma/atopy or healthy controls were incubated under normoxia and hypoxia, with or without glucocorticoids. Activation was measured by flow cytometry, ELISA of cultured supernatants, and F-actin staining; apoptosis and efferocytosis by morphology and flow cytometry; and GCS efficacy by apoptosis assays and qPCR. Hypoxic incubation (3 kPa) caused (i) stabilization of HIF-2α and up-regulation of hypoxia-regulated genes including BNIP3 (BCL2/adenovirus E1B 19-kDa protein-interacting protein 3) and GLUT1 (glucose transporter 1); (ii) secretion of pre-formed IL-8, and Charcot Leyden crystal (CLC) formation, which was most evident in eosinophils derived from atopic and asthmatic donors; (iii) enhanced F-actin formation; (iv) marked prolongation of eosinophil lifespan (via a NF-κB and Class I PI3-kinase-dependent mechanism); and (v) complete abrogation of the normal pro-apoptotic effect of dexamethasone and fluticasone furoate. This latter effect was evident despite preservation of GCS-mediated gene transactivation under hypoxia. These data indicate that hypoxia promotes an eosinophil pro-inflammatory phenotype by enhancing eosinophil secretory function, delaying constitutive apoptosis, and importantly, antagonizing the normal pro-apoptotic effect of GCS. As eosinophils typically accumulate at sites that are relatively hypoxic, particularly during periods of inflammation, these findings may have important implications to understanding the

  18. The origin of art according to Karl von den Steinen

    Directory of Open Access Journals (Sweden)

    Pierre Déléage

    2015-06-01

    Full Text Available Based on a study of the custom, adopted by ethnologists in the early 20th century, of asking Amerindians of Lowland South America to do drawings in pencil in their notebooks, I explore three forgotten fragments of the history of thinking: the intense debates on the origin of ornaments, opposing an evolutionist and a materialist approach at the end of the 19th century; the theories on the origin of figuration, which I show date back to the important work of Karl von den Steinen regarding the populations of central Brazil; and the publications of ethnologists’ portraits drawn by Indians of the lowlands of South America, a little-known tradition of reverse anthropology serving as a counterpoint to the study of the reception of Amerindian art in Western ethnological literature.

  19. Nyttan av franchising i den svenska fastighetsmäklarbranschen

    OpenAIRE

    Herke, Marie; Olivers, Marielle

    2012-01-01

    Franchising är det mest vanliga kedjekonceptet i fastighetsmäklarbranschen och flera av de största fastighetsmäklarkedjorna är franchisekedjor. De fristående mäklarbyråerna får allt svårare att klara sig i den ökade konkurrensen. Det är främst fristående mäklarbyråer på mindre orter med ett etablerat varumärke samt nischade mäklarbyråer som klarar sig i konkurrensen med de stora kedjorna. På senare år har antalet kedjeanslutna fastighetsmäklare ökat betydligt och flertalet av mäklarkedjorna ä...

  20. Subregional innovation – indikatorer til optimering af den erhvervsrettede innovationspolitik

    DEFF Research Database (Denmark)

    Mortensen, Peter Stendahl; Graversen, Ebbe Krogh; Haase, Sanne Schioldann

    områder tilgodeses bedst muligt. Desuden kan en differentieret, subregional innovations-politik give erhvervslivet bedre udbytte end en samlet regional eller national innovationspolitik. Selvom Danmark er et lille land, er der store geografiske forskelle internt i landets erhvervsstruktur og i...... virksomhedernes innovationsaktiviteter. Som resultat af en udvidelse af den danske del af CIS 2006-undersøgelsen2 med ekstra virksomheder kan der gives en betydeligt mere nuanceret karak-teristik af virksomheder helt ned på subregionalt niveau. Analysen underbygger, at de innovations-politiske tiltag, der sættes......, lokal brug af resultaterne er nødvendig. Først gennemgås de valgte målepunkter. Det primære er en opdeling i praksis- og forsknings-orientering af virksomheders innovationstilgang, hvorved der identificeres fire grupper af innovationsaktive virksomheder. Det andet er korrektion af de anvendte...

  1. Types and forms of sleeping dens of pacas (Cuniculus paca in the upper Itaya river basin

    Directory of Open Access Journals (Sweden)

    Rolando Aquino

    2012-10-01

    Full Text Available This report deals with paca sleeping dens (Cuniculus paca Linnaeus, 1766. The study was conducted between August 2006 and April 2007 and is based on detailed observations. Results indicate that this rodent uses holes in the ground or in fallen trees as sleeping dens. Each of these sleeping dens had two or more orifices and an internal cavity for the "diurnal sleep”. Typically, one orifice was for common use and the rest for the circumstantial escape. According to their form, their localization in the ground, and the number and location of orifices, sleeping dens were classified into four types, of which type A was the most common. The results also indicate a greater concentration of sleeping dens in temporary flooded gallery forest.

  2. Die polnischen Bücher (Bücherbestände in den Bibliotheken Roms. Eine Auswahl

    Directory of Open Access Journals (Sweden)

    Ligia ALeksandra Henczel-Wróblewska

    2017-11-01

    Full Text Available Die italienisch-polnischen Beziehungen haben eine lange Geschichte hinter sich. Seit dem Mittelalter, in dem die polnischen Scholaren ihre Ausbildung an den italienischen Universitäten genießen konnten, dominierte darin der wissenschaftliche und bildende Charakter. In den folgenden Jahrhunderten wurde der gegenseitige Kontakt um die künstlerische Ebene erweitert, zumal die polnischen Künstler nach Italien reisten, um bei den besten Meistern ihre Fertigkeiten zu vervollkommnen. Seit dem Ende des 18. bis zur Mitte des 19. Jahrhunderts kam zu den bereits bestehenden, tradierten italienischpolnischen Beziehungen im Bereich der Wissenschaft und Kultur der militärische und der sozialpolitische Aspekt hinzu, und mit der Zeit auch der wirtschaftliche. Auf dem italienischen Boden beteiligten sich die Polen zunächst an den Unabhängigkeitskämpfen, die mit der Vereinigung Italiens (die Risorgimento-Zeit endeten, und nachher an den Waffeninterventionen während der zwei Weltkriege. Seit der Mitte des 20. Jahrhunderts kehrte man zum früheren beiderseitigen Kontakt auf verschiedenen Ebenen zurück.In jeder dieser Zeitspannen wurde die polnische Anwesenheit in Italien in den schriftlichen, ikonografischen, künstlerischen Quellen belegt. Die meisten davon bewährten sich in den Archiven und Bibliotheken Roms, dem Zentrum der europäischen Wissenschaft, Kultur und Christenheit. Erst im 20. Jahrhundert, seit der Entstehung der ersten wissenschaftlichen polnischen Institutionen in Rom und dank der breiten Zusammenarbeit war es möglich, die Polonica, die sich in den römischen Bibliotheken, Archiven, Kulturinstitutionen und Privatbeständen befinden, offiziell zu registrieren, bearbeiten und ordnen. Die schriftlichen Denkmäler aus den vergangenen Jahrhunderten weisen auf eine breite gegenseitige Beziehung sowohl im Bereich des sacrum als auch des profanum hin. Dieses gemeinsame historische Gedächtniserbe zeugt von einer langen Zugehörigkeit Polens zur

  3. X-linked Charcot-Marie-Tooth disease, Arts syndrome, and prelingual non-syndromic deafness form a disease continuum: evidence from a family with a novel PRPS1 mutation

    NARCIS (Netherlands)

    Synofzik, Matthis; Müller Vom Hagen, Jennifer; Haack, Tobias B.; Wilhelm, Christian; Lindig, Tobias; Beck-Wödl, Stefanie; Nabuurs, Sander B.; van Kuilenburg, André B. P.; de Brouwer, Arjan P. M.; Schöls, Ludger

    2014-01-01

    X-linked Charcot-Marie-Tooth disease type 5 (CMTX5), Arts syndrome, and non-syndromic sensorineural deafness (DFN2) are allelic syndromes, caused by reduced activity of phosphoribosylpyrophosphate synthetase 1 (PRS-I) due to loss-of-function mutations in PRPS1. As only few families have been

  4. Anesthetic and Surgical Management of a Bilateral Mandible Fracture in a Patient With Charcot-Marie-Tooth Disease: A Case Report.

    Science.gov (United States)

    Smith, Jeffrey D; Minkin, Patton; Lindsey, Sean; Bovino, Brian

    2015-10-01

    This report describes the case of a 74-year-old man who had been diagnosed with Charcot-Marie-Tooth disease as a child. Because the patient had serious motor and sensory neuropathy associated with his disease, special anesthetic and surgical recommendations had to be considered before he underwent general anesthesia to repair his mandibular fracture. Repair of the mandible was performed under general anesthesia with a nasal endotracheal tube and the use of the nondepolarizing muscle relaxant rocuronium. Open reduction and internal fixation through extraoral approaches were used to fixate the displaced right subcondylar and symphyseal fractures. A closed reduction approach using maxillary fixation screws and a mandibular arch bar with light elastic guidance was used to treat a nondisplaced fracture of the left mandibular ramus. Rigid fixation allowed for avoidance of a period of intermaxillary fixation. General anesthesia and muscle relaxant were administered without complication. Treatment of bilateral mandibular fractures with combined open and closed approaches resulted in restoration of premorbid occlusion and masticatory function. Repair of mandibular fractures under general anesthesia appears to be a safe procedure in patients with Charcot-Marie-Tooth disease when appropriate anesthetic and surgical methods are used. Copyright © 2015 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.

  5. A novel mouse model carrying a human cytoplasmic dynein mutation shows motor behavior deficits consistent with Charcot-Marie-Tooth type 2O disease.

    Science.gov (United States)

    Sabblah, Thywill T; Nandini, Swaran; Ledray, Aaron P; Pasos, Julio; Calderon, Jami L Conley; Love, Rachal; King, Linda E; King, Stephen J

    2018-01-29

    Charcot-Marie-Tooth disease (CMT) is a peripheral neuromuscular disorder in which axonal degeneration causes progressive loss of motor and sensory nerve function. The loss of motor nerve function leads to distal muscle weakness and atrophy, resulting in gait problems and difficulties with walking, running, and balance. A mutation in the cytoplasmic dynein heavy chain (DHC) gene was discovered to cause an autosomal dominant form of the disease designated Charcot-Marie-Tooth type 2 O disease (CMT2O) in 2011. The mutation is a single amino acid change of histidine into arginine at amino acid 306 (H306R) in DHC. In order to understand the onset and progression of CMT2, we generated a knock-in mouse carrying the corresponding CMT2O mutation (H304R/+). We examined H304R/+ mouse cohorts in a 12-month longitudinal study of grip strength, tail suspension, and rotarod assays. H304R/+ mice displayed distal muscle weakness and loss of motor coordination phenotypes consistent with those of individuals with CMT2. Analysis of the gastrocnemius of H304R/+ male mice showed prominent defects in neuromuscular junction (NMJ) morphology including reduced size, branching, and complexity. Based on these results, the H304R/+ mouse will be an important model for uncovering functions of dynein in complex organisms, especially related to CMT onset and progression.

  6. Novel Semiquantitative Bone Marrow Oedema Score and Fracture Score for the Magnetic Resonance Imaging Assessment of the Active Charcot Foot in Diabetes

    Science.gov (United States)

    Meacock, L.; Donaldson, Ana; Isaac, A.; Briody, A.; Ramnarine, R.; Edmonds, M. E.; Elias, D. A.

    2017-01-01

    There are no accepted methods to grade bone marrow oedema (BMO) and fracture on magnetic resonance imaging (MRI) scans in Charcot osteoarthropathy. The aim was to devise semiquantitative BMO and fracture scores on foot and ankle MRI scans in diabetic patients with active osteoarthropathy and to assess the agreement in using these scores. Three radiologists assessed 45 scans (Siemens Avanto 1.5T, dedicated foot and ankle coil) and scored independently twenty-two bones (proximal phalanges, medial and lateral sesamoids, metatarsals, tarsals, distal tibial plafond, and medial and lateral malleoli) for BMO (0—no oedema, 1—oedema  50% of bone volume) and fracture (0—no fracture, 1—fracture, and 2—collapse/fragmentation). Interobserver agreement and intraobserver agreement were measured using multilevel modelling and intraclass correlation (ICC). The interobserver agreement for the total BMO and fracture scores was very good (ICC = 0.83, 95% confidence intervals (CI) 0.76, 0.91) and good (ICC = 0.62; 95% CI 0.48, 0.76), respectively. The intraobserver agreement for the total BMO and fracture scores was good (ICC = 0.78, 95% CI 0.6, 0.95) and fair to moderate (ICC = 0.44; 95% CI 0.14, 0.74), respectively. The proposed BMO and fracture scores are reliable and can be used to grade the extent of bone damage in the active Charcot foot. PMID:29230422

  7. Die Entwicklung der Keramik von 3000 BP bis zur Gegenwart in den Tonebenen südlich des Tschadsees

    OpenAIRE

    Wiesmüller, Birgitt

    2003-01-01

    Den Kern der hier vorliegenden Arbeit bildet die Gliederung der Keramikfunde von drei Siedlungshügeln aus den Tonebenen (auch firki genannt) des südwestlichen Tschadbeckens Nordost- Nigerias. Obwohl das Gebiet in den 60er Jahren bereits archäologisch erschlossen wurde, waren die keramikchronologischen Aspekte nur oberflächlich abgehandelt worden. Ziel der Arbeit war somit die Erstellung einer grundlegenden Keramikchronologie anhand der sehr umfangreichen Fundmengen aus den Siedlungshügeln Kur...

  8. Den enes död, den andres bröd : En fallstudie i Fonus kriskommunikation

    OpenAIRE

    Orest Flavet, Sebastian

    2014-01-01

    Denna studie undersöker hur begravningsbyrån Fonus valde att bemöta en kritisk artikel, publicerad i Aftonbladet, med ett pressmeddelande som lades upp på den egna hemsidan. Uppsatsen undersöker först vilka retoriska verktyg som har använts i skapandet av detta meddelande, och sett från Benoits teori om Image Repair, vilka strategier som använts och hur användningen av dessa har sett ut. Därefter söker studien att praktiskt undersöka detta budskap genom att låta en utvald grupp respondenter t...

  9. Hibernacula and summer den sites of pine snakes (Pituophis melanoleucus) in the New Jersey pine barrens

    Science.gov (United States)

    Burger, J.; Zappalorti, R.T.; Gochfeld, M.; Boarman, W.I.; Caffrey, M.; Doig, V.; Garber, S.D.; Lauro, B.; Mikovsky, M.; Safina, C.; Saliva, Jorge

    1988-01-01

    We examined eight summer dens (used only in summer) and seven hibernacula (occupied both in winter and summer) of the snake Pituophis melanoleucus in the New Jersey Pine Barrens, comparing above ground characteristics of hibernacula and summer dens with characteristics at nearby random points. Temperatures at the soil surface and at 10 cm depth were significantly warmer, and there was less leaf cover around the random points compared to the entrances of the hibernacula and summer dens. Hibernacula had significantly more vegetation cover within 5 m, more leaf cover over the burrow entrance, and were closer to trees than were summer dens. Most hibernacula and summer dens were beside old fallen logs (73%), the entrance tunnels following decaying roots into the soil. Excavation of the hibernacula and summer dens indicated that most hibernacula appeared to be dug by the snakes and had an average of eight side chambers and 642 cm of tunnels, compared to less than one side chamber and 122 cm of tunnels for summer dens. Except for hatchlings, most snakes in hibernacula were located in individual chambers off the main tunnel; all snakes were at depths of 50-111 cm (X̄ = 79 cm). Pine snakes may select optimum hibernation sites which reduce winter mortality.

  10. Conservative Management of Type III Dens in Dente Using Cone Beam Computed Tomography

    Directory of Open Access Journals (Sweden)

    K Pradeep

    2012-01-01

    Full Text Available Dens in dente, also known as dens invaginatus, dilated composite odontoma, or deep foramen caecum, is a developmental malformation that usually affects maxillary incisor teeth, particularly lateral incisors. It may occur in teeth anywhere within the jaws, other locations are comparatively rare. It can occur within both the crown and the root, although crown invaginations are more common. The use of cone beam computed tomography (CBCT is very helpful in endodontic diagnosis of complex anatomic variations. In this case we demonstrate the use of CBCT in the evaluation and endodontic management of a Type III dens in dente (Oehler′s Type III.

  11. Skaber den nye økonomi højere produktivitet?

    DEFF Research Database (Denmark)

    Dilling-Hansen, Mogens; Madsen, Erik Strøjer; Smith, Valdemar

    2001-01-01

    Den kraftige og vedvarende vækst i USA og det tilhørende boom i IT-sektoren er grundlaget for begrebet 'Den nye Økonomi', der er dukket op i sidste halvdel af 90'erne. Den grundlæggende sammenhæng mellem de to fænomener er, at IT-industrien i sig selv og produktivitetsstigninger i de øvrige branc......-sektoren i servicesektoren, der har haft store produktivitetsstigninger. Det gælder også for telekommunikationssektoren, medens der blandt IT-konsulentvirksomheder lidt overraskende ikke kan påvises tilsvarende produktivitetsstigninger....

  12. Schulze and Brand type a-IV dens invaginatus with radicular cyst: A rare case report

    Directory of Open Access Journals (Sweden)

    Rachita Chengappa

    2015-01-01

    Full Text Available Though a clinical examination may reveal a deep fissure or pit on the surface of an anterior tooth, radiographic examination is a more accurate approach to diagnose an invagination. Dens invaginatus is one of the common dental deformities, but the defect involving the root and its association with radicular cyst is still very uncommon. The objective of this case presentation is to report a case of radicular dens in dente, which is a rare dental anomaly. This case report shows that dens invaginatus with an open apex and a radicular cyst can be treated successfully using currently available materials.

  13. Einfluss repetitiver postprandialer Hyperglykämien auf den kardialen Ischämie- und Reperfusionsschaden

    OpenAIRE

    Elbing, Inka Lena

    2008-01-01

    Die vorliegende Arbeit befasste sich daher mit dem Effekt von Acarbose auf die durch Ischämie und Reperfusion verursachten myokardialen Schäden nach Saccharosebelastung bei gesunden Mäusen in vivo. Aus den Ergebnissen dieser Arbeit lässt sich ableiten, dass eine wiederholte postprandiale Hyperglykämie bei nicht - diabetischen Tieren ausreicht, um die durch Ischämie und Reperfusion verursachten Myokardschäden signifikant zu erhöhen. Dies kann durch eine Behandlung mit dem a - Glucosidase - Hem...

  14. Implantate für den Bandscheibenersatz (Stand 1993)

    Science.gov (United States)

    Mathey, Michael; Wintermantel, Erich

    Die Bandscheiben sind besonders betroffen von Fehlhaltungen und -stellungen der Wirbelsäule. Sie unterliegen als grösstes zusammenhängendes, nicht vaskularisiertes Gewebe im Menschen, statisch und dynamisch extrem belastet, besonders der Alterung. Um die teilweise sehr starken Schmerzen bei Bandscheibenschädigungen zu lindern, ist eine Operation vielfach die einzige Hilfe. Bei dieser Operation (Nukleotomie) entfernt man das aus der Bandscheibe ausgetretene Gewebe des Gallertkerns (nucleus pulposus), welches durch Druck auf die Nervenstränge im Bereich der Wirbelsäule die Beschwerden (Ischias-Schmerz) verursacht hat. Nach der Entfernung des Gallertkerns werden die auftretenden Kräfte bei veränderter Biomechanik übertragen. Dabei erhalten die Zwischenwirbelgelenke (Facettengelenke) eine erheblich grössere Flächenpressung als dies bei intakter Bandscheibe der Fall war. Die höhere Flächenpressung kommt durch die Verringerung des Abstandes zwischen den oberen und unteren Deckplatten der benachbarten Wirbelkörper zustande, zwischen denen sich der Gallertkern befand. Durch geeignetes Training der Rückenmuskulatur kann eine Stabilisierung des operierten Bandscheibensegmentes erreicht werden, jedoch ist es eine klinische Erfahrung, dass die meisten Patienten, die momentan durch die Operation schmerzfrei geworden sind, keine adäquate zusätzliche sportliche Betätigung auf sich nehmen.

  15. Om den uformelle (misbrug af medier i det formelle uddannelsessystem

    Directory of Open Access Journals (Sweden)

    Michael Paulsen

    2009-06-01

    Full Text Available En kombination af uddannelsesforskning og medieforskning anvendes til at forstå gymnasieelevers brug af nye digitale medier. På baggrund af elev- og lærerinterview fremlægger forfatterne en tolkning af mediebrugens betydning for de formelle læreprocesser. Artiklen kommer frem til, at medierne afleder elevernes opmærksomhed og fører til afhængighedsproblemer. Forfatterne fremlægger en tolkning af, hvordan eleverne afledes, og hvad de afledes til. Igennem denne tolkning kommer artiklen frem til, at medier som Messenger ikke blot afleder opmærksomhed, men også dekonstruerer forskellen mellem formelle og uformelle læreprocesser. I modsætning til, hvad eleverne og lærerne selv fortæller, indikerer tolkningen, at der finder en læring sted via elevernes dekonstruerende brug af de nye medier, men at lærerne ekskluderes fra de processer, hvorigennem læringen initieres. Artiklen konkluderer, at der bør udvikles en mediedidaktik, der dels afhjælper elevers afhængighedsproblemer, dels giver lærerne styrke til at spille en aktiv rolle ift. den sociale interaktion og læring, som de nye medier muliggør.

  16. Om den uformelle (misbrug af medier i det formelle uddannelsessystem

    Directory of Open Access Journals (Sweden)

    Michael Paulsen

    2008-09-01

    Full Text Available En kombination af uddannelsesforskning og medieforskning anvendes til at forstå gymnasieelevers brug af nye digitale medier. På baggrund af elev- og lærerinterview fremlægger forfatterne en tolkning af mediebrugens betydning for de formelle læreprocesser. Artiklen kommer frem til, at medierne afleder elevernes opmærksomhed og fører til afhængighedsproblemer. Forfatterne fremlægger en tolkning af, hvordan eleverne afledes, og hvad de afledes til. Igennem denne tolkning kommer artiklen frem til, at medier som Messenger ikke blot afleder opmærksomhed, men også dekonstruerer forskellen mellem formelle og uformelle læreprocesser. I modsætning til, hvad eleverne og lærerne selv fortæller, indikerer tolkningen, at der finder en læring sted via elevernes dekonstruerende brug af de nye medier, men at lærerne ekskluderes fra de processer, hvorigennem læringen initieres. Artiklen konkluderer, at der bør udvikles en mediedidaktik, der dels afhjælper elevers afhængighedsproblemer, dels giver lærerne styrke til at spille en aktiv rolle ift. den sociale interaktion og læring, som de nye medier muliggør.

  17. A realidade da pesquisa no DEN/UFS

    Directory of Open Access Journals (Sweden)

    Delvair de Brito Alves

    1998-12-01

    Full Text Available Esta pesquisa trata do processo de pesquisar no Departamento de Enfermagem e Nutrição da Universidade Federal de Sergipe - DEN/UFS. Ela foi desenvolvida a partir de entrevistas semi estruturadas realizadas com as docentes. Dos materiais obtidos, apresentamos concepções das docentes sobre grupos, linhas e projetos de pesquisa; a produção científica docente e discente; dificuldades e possibilidades relativas à atividade de pesquisar; estratégias que esse Departamento vem utilizando para o desenvolvimento da pesquisa, para a capacitação docente e formação de pesquisadores, além da inserção de estudantes (de graduação e de pós graduação no "mundo científico". Ela conclui pela necessidade de aprofundamento dessa atividade e pela divulgação e aplicação dos seus resultados na prática de enfermagem.

  18. [Memel als Brücke zu den baltischen Ländern] / Ralph Tuchtenhagen

    Index Scriptorium Estoniae

    Tuchtenhagen, Ralph, 1961-

    2014-01-01

    Arvustus: Memel als Brücke zu den baltischen Ländern. Kulturgeschichte Klaipedas vom Mittelalter bis ins 20. Jahrhundert. (Tagungsberichte der Historischen Kommission für ost- und westpreussische Landesforschung. Bd. 26)

  19. Good-Practice-Ansätze für den Dienstleistungseinkauf

    OpenAIRE

    Hänsel, Martin; Hofmann, Erik

    2017-01-01

    Die Performance Excellence Studie des Lehrstuhls für Logistikmanagement der Hochschule St. Gallen (HSG) zeigt auf, was moderne Unternehmen tun müssen, wenn sie den Einkauf von Dienstleistungen zeitgemäss handhaben wollen.

  20. Type II dens evaginatus of maxillary central incisor: An alternative approach

    Directory of Open Access Journals (Sweden)

    Mansour Alrejaie

    2015-01-01

    Full Text Available Dens evaginatus is the developmental anomaly of tooth that exhibits protrusion of a tubercle from occlusal surfaces of premolar, and lingual surfaces of maxillary central incisor and lateral incisors. Dens evaginatus is common in Caucasian population. Saudi Arabia is also well evidenced of such cases. These tubercles have an enamel layer covering dentin core containing a thin extension of pulp. These cusp-like protrusions are susceptible to pulp exposure from wear or fracture because of malocclusion. Type II dens evaginatus involves normal pulp with immature root apex. Materials to enhance the pulpal recession or pulpotomy procedures indicated in such cases require long time and efforts to ensure pulpal recession or root maturity, respectively. Also prolonged treatment has risk of fracture of the cusp and reinfection and requires patient commitment for the follow-up procedures. Present case describes the use of mineral trioxide aggregate (MTA in type II dens evaginatus of maxillary central incisor.

  1. GMO-afgrøder ikke den eneste løsning

    DEFF Research Database (Denmark)

    Jacobsen, Niels; Jacobsen, Sven-Erik; Sørensen, Marten

    2010-01-01

    Er GMO-afgrøder den optimale løsning på klodens fremtidige plantebaserede fødevareproduktion? Findes der alternativer? Det er der to meget klare svar på:GMOafgrøderer ikke den eneste løsning, og ja, der findes mange og langt mere attraktive, bæredygtige løsninger......Er GMO-afgrøder den optimale løsning på klodens fremtidige plantebaserede fødevareproduktion? Findes der alternativer? Det er der to meget klare svar på:GMOafgrøderer ikke den eneste løsning, og ja, der findes mange og langt mere attraktive, bæredygtige løsninger...

  2. Børnebøger : Døden er en del af livet

    DEFF Research Database (Denmark)

    Petersen, Anne

    2010-01-01

    Der findes mange kvalitetsbøger, som giver børn en litterær hjælpende hånd til at håndtere de store eksistentielle spørgmål om døden, og som kan lette sorgen. Bøgerne er ofte lune og usentimentale, men kan være højtidelige. På den fine måde.......Der findes mange kvalitetsbøger, som giver børn en litterær hjælpende hånd til at håndtere de store eksistentielle spørgmål om døden, og som kan lette sorgen. Bøgerne er ofte lune og usentimentale, men kan være højtidelige. På den fine måde....

  3. [Ulrike Plath. Esten und Deutsche in den baltischen Provinzen Russlands] / Olaf Mertelsmann

    Index Scriptorium Estoniae

    Mertelsmann, Olaf, 1969-

    2013-01-01

    Arvustus: Plath, Ulrike. Esten und Deutsche in den baltischen Provinzen Russlands: Freundheitskonstruktionen, lebenswelten, Kolonialphantasien 1750-1810 (Veröffenlichungen des Nordost-Instituts, Bd. 11.)Harrasowitz. Wiesbaden 2011

  4. Den årlige klining af moskéen i Jenné

    DEFF Research Database (Denmark)

    Andreasen, Jørgen

    2007-01-01

    Danske studerende hjælper med kliningen af den store moské i Jenné under 'Mohammed-krisen'. Jenné er et af UNESCO's 'heritage sites' - en by helt bygget i ler. Vedligeholdelse og årlig klining er nødvendig. Moskeen er den største bygning, lukket for ikke-muslimer. Det danske hold fik adgang til m...

  5. Vom Fachwissen zur Handlungskompetenz - die Berufsschule vor den Herausforderungen des sozioökonomischen Strukturwandels

    OpenAIRE

    Kouli, Ekaterina

    2006-01-01

    Der sozioökonomische Wandel und die damit einhergehenden Veränderungen der Wirtschafts- und Beschäftigungsstrukturen stellen das Bildungssystem in Deutschland vor neuartige Herausforderungen. Wesentliche Momente dieses Wandels sind die technologische Entwicklung, die Globalisierung der Wirtschaft, der Übergang von der Industrie- zur Wissensgesellschaft sowie Veränderungen in den gesellschaftlichen Wertvorstellungen. Diese Entwicklungen verändern die Arbeitsprozesse in den Unternehmen und dami...

  6. Den europæiske drøm - om EU

    DEFF Research Database (Denmark)

    Østergaard, Uffe

    2007-01-01

    Anmeldelse af: Jeremy Rifkin: Den europæiske drøm (Informations Forlag, 2006). Oversat fra engelsk efter: "The European Dream: How Europe's Vision of the Future Is Quietly Eclipsing the American Dream" (2004)......Anmeldelse af: Jeremy Rifkin: Den europæiske drøm (Informations Forlag, 2006). Oversat fra engelsk efter: "The European Dream: How Europe's Vision of the Future Is Quietly Eclipsing the American Dream" (2004)...

  7. Hoffen auf den guten Willen – von der unverbindlichen Institutionalisierung feministischer Forderungen

    Directory of Open Access Journals (Sweden)

    Maike Bußmann

    2008-11-01

    Full Text Available Nachdem die Protagonistinnen der ersten Frauenbewegung prinzipiell den Zugang in die Institutionen erstritten hatten, wurde seit den 1968ern der Marsch durch die Institutionen angetreten. Diesen untersucht Stefanie Ehmsen für die Vereinigten Staaten und die Bundesrepublik, wobei sie die Unterschiede als Resultat der jeweiligen politischen Traditionen interpretiert. Zwar wartet sie mit gut recherchierten und lesenswerten Fallbeispielen auf, doch das Potential der Analyse wird leider nicht ausgeschöpft.

  8. Den 'dygtige' lærer er en del af problemet

    DEFF Research Database (Denmark)

    Hedegaard-Sørensen, Lotte

    2016-01-01

    Lærerne lever faktisk op til politikernes forestilling om ’den gode undervisning’, men dermed bliver de en del af problemet og ikke løsningen på folkeskolens inklusionsudfordring......Lærerne lever faktisk op til politikernes forestilling om ’den gode undervisning’, men dermed bliver de en del af problemet og ikke løsningen på folkeskolens inklusionsudfordring...

  9. Den første Karl Gustav-krig 1657-58

    DEFF Research Database (Denmark)

    Olden-Jørgensen, Sebastian

    2008-01-01

    Artiklen diskuterer den første Karl Gustav-krig i forskellige persketiver og konkluderer, at krigen ikke bør opfattes som et dårligt forberedt og uigennemtænkt forsøg på dansk revanche inden for rammerne af en nordisk rivalisering, men snarere som  en velovervejet satsning og et led i den dansk-s...

  10. Loyalitet i praksis:En etnologisk kulturanalyse af fænomenet den loyale forbruger

    OpenAIRE

    Breddam, Mads Dupont

    2015-01-01

    Loyalitet i praksis – en etnologisk kulturanalyse af fænomenet den loyale forbruger , er en kvalitativ kulturanalyse af, hvordan loyalitet skabes i forbindelse med den danske detailhandels - og andelsorganisation Coop og Coops loyalitetsprogram CoopPlus. Undersøgelserne bygger på et empirisk materiale , som hovedsageligt består af kvalitative interviews med en række medlemmer og medejere af Coop samt med medarbejdere i Coops hovedkvarter i Albertslund . Afhandlingen er en praksiografisk under...

  11. Køn og kærlighed i Den Hebraiske Bibel og tidlig rabbinsk litteratur

    DEFF Research Database (Denmark)

    Schleicher, Marianne

    2014-01-01

    De religiøse grundlæggertekster synes optaget af at sikre kulturens videreførelse gennem entydiggørelse af køn og kærlighed, men den hebræiske bibel og den tidlige rabbinske litteratur skildrer lige så ofte i de mest dramatiske og poetiske passager køn og kærlighed som komplekse, sammensatte, for...

  12. Rapportering om going concern i den nye revisionspåtegning

    DEFF Research Database (Denmark)

    Seehausen, Jesper

    2017-01-01

    Artiklen omhandler revisors rapportering om going concern i den nye revisionspåtegning. Det er artiklens centrale budskab, at der i den nye revisionspåtegning alene er ændringer til, hvordan revisor skal rapportere om going concern i revisionspåtegningen. Der er derimod ikke ændringer til, hvornår...... revisor skal rapportere om going concern i revisionspåtegningen....

  13. Shareholder Kapitalismus und das Casino Spiel an den Börsen

    OpenAIRE

    Young, Brigitte; Hegelich, Simon

    2003-01-01

    'Das Konzept des Shareholder Value ist durch die jüngsten Entwicklungen im Unternehmenssektor, vor allem durch die Bilanz- und Betrugsskandale von TNC's und die damit verbundene Vernichtung von Arbeitsplätzen in die Kritik geraten. In den politischen Debatten über Shareholder Value wird ein Systemunterschied zwischen dem 'Stakeholder-Ansatz' (wie im rheinischen Kapitalismus) und dem mit der Liberalisierung der Finanzmärkte Ende der 70er Jahre in den USA entwickelten Begriff Shareholder Value ...

  14. Remote identification of maternal polar bear (Ursus maritimus) denning habitat on the Colville River Delta, Alaska

    Science.gov (United States)

    Blank, Justin J.

    High resolution digital aerial photographs (1 foot pixel size) of the Colville River Delta, Alaska were examined in 3D, with the use of a digital photogrammetric workstation. Topographic features meeting the criteria required for adequate snow accumulation, and subsequent construction of terrestrial polar bear maternal dens, were identified and digitized into an ArcGIS line shapefile. Effectiveness, efficiency, and accuracy were improved when compared to previous polar bear denning habitat efforts which utilized contact photo prints and a pocket stereoscope in other geographic areas of northern Alaska. Accuracy of photograph interpretation was systematically evaluated visually from the air with the use of a helicopter and physically on the ground. Results show that the mapping efforts were successful in identifying den habitat 91.3% of the time. Knowledge denning habitat can improve and inform decision making by managers and regulators when considering travel and development in the study area. An understanding of polar bear denning habitat extent and location will be a crucial tool for planning activities within the study area in a way that minimizes conflicts with maternal dens.

  15. Multiplex Detection and Genotyping of Point Mutations Involved in Charcot-Marie-Tooth Disease Using a Hairpin Microarray-Based Assay

    Directory of Open Access Journals (Sweden)

    Yasser Baaj

    2009-01-01

    Full Text Available We previously developed a highly specific method for detecting SNPs with a microarray-based system using stem-loop probes. In this paper we demonstrate that coupling a multiplexing procedure with our microarray method is possible for the simultaneous detection and genotyping of four point mutations, in three different genes, involved in Charcot-Marie-Tooth disease. DNA from healthy individuals and patients was amplified, labeled with Cy3 by multiplex PCR; and hybridized to microarrays. Spot signal intensities were 18 to 74 times greater for perfect matches than for mismatched target sequences differing by a single nucleotide (discrimination ratio for “homozygous” DNA from healthy individuals. “Heterozygous” mutant DNA samples gave signal intensity ratios close to 1 at the positions of the mutations as expected. Genotyping by this method was therefore reliable. This system now combines the principle of highly specific genotyping based on stem-loop structure probes with the advantages of multiplex analysis.

  16. A Costa Rican family affected with Charcot-Marie-Tooth disease due to the myelin protein zero (MPZ p.Thr124Met mutation shares the Belgian haplotype

    Directory of Open Access Journals (Sweden)

    Alejandro Leal

    2014-12-01

    Full Text Available The p.Thr124Met mutation in the myelin protein zero (MPZ causes the Charcot-Marie-Tooth disease type 2J, a peripheral neuropathy with additional symptoms as pupillary alterations and deafness. It was observed in several families around the world originating e. g. from Germany, Belgium, Japan, Italy and North America. Here we report Central American patients originating from a family in Costa Rica carrying this mutation. Clinical, electrophysiological and molecular analysis of patients and controls were performed, including gene and linked markers´ sequencing. Carriers share almost the entire haplotype with two non related Belgian CMT patients. As a result of the haplotype analysis, based on ten markers (seven SNPs, two microsatellites and an intronic polyA stretch, the founder effect hypothesis for this allele migration is suggestive. Rev. Biol. Trop. 62 (4: 1285-1293. Epub 2014 December 01.

  17. Four novel connexin 32 mutations in X-linked Charcot-Marie-Tooth disease. Phenotypic variability and central nervous system involvement.

    Science.gov (United States)

    Karadima, Georgia; Koutsis, Georgios; Raftopoulou, Maria; Floroskufi, Paraskewi; Karletidi, Karolina-Maria; Panas, Marios

    2014-06-15

    Charcot-Marie-Tooth (CMT) disease, the most common hereditary neuropathy, is clinically and genetically heterogeneous. X-linked CMT (CMTX) is usually caused by mutations in the gap junction protein b 1 gene (GJB1) coding for connexin 32 (Cx32). The clinical manifestations of CMTX are characterized by significant variability, with some patients exhibiting central nervous system (CNS) involvement. We report four novel mutations in GJB1, c.191G>A (p.Cys64Tyr), c.508G>T (p.Val170Phe), c.778A>G (p.Lys260Glu) and c.300C>G (p.His100Gln) identified in four unrelated Greek families. These mutations were characterized by variable phenotypic expression, including a family with the Roussy-Lévy syndrome, and three of them were associated with mild clinical CNS manifestations. Copyright © 2014. Published by Elsevier B.V.

  18. Early-onset osteoarthritis, Charcot-Marie-Tooth like neuropathy, autoimmune features, multiple arterial aneurysms and dissections: an unrecognized and life threatening condition.

    Directory of Open Access Journals (Sweden)

    Mélodie Aubart

    Full Text Available BACKGROUND: Severe osteoarthritis and thoracic aortic aneurysms have recently been associated with mutations in the SMAD3 gene, but the full clinical spectrum is incompletely defined. METHODS: All SMAD3 gene mutation carriers coming to our centre and their families were investigated prospectively with a structured panel including standardized clinical workup, blood tests, total body computed tomography, joint X-rays. Electroneuromyography was performed in selected cases. RESULTS: Thirty-four SMAD3 gene mutation carriers coming to our centre were identified and 16 relatives were considered affected because of aortic surgery or sudden death (total 50 subjects. Aortic disease was present in 72%, complicated with aortic dissection, surgery or sudden death in 56% at a mean age of 45 years. Aneurysm or tortuosity of the neck arteries was present in 78%, other arteries were affected in 44%, including dissection of coronary artery. Overall, 95% of mutation carriers displayed either aortic or extra-aortic arterial disease. Acrocyanosis was also present in the majority of patients. Osteoarticular manifestations were recorded in all patients. Joint involvement could be severe requiring surgery in young patients, of unusual localization such as tarsus or shoulder, or mimicking crystalline arthropathy with fibrocartilage calcifications. Sixty eight percent of patients displayed neurological symptoms, and 9 suffered peripheral neuropathy. Electroneuromyography revealed an axonal motor and sensory neuropathy in 3 different families, very evocative of type II Charcot-Marie-Tooth (CMT2 disease, although none had mutations in the known CMT2 genes. Autoimmune features including Sjogren's disease, rheumatoid arthritis, Hashimoto's disease, or isolated autoantibodies- were found in 36% of patients. INTERPRETATION: SMAD3 gene mutations are associated with aortic dilatation and osteoarthritis, but also autoimmunity and peripheral neuropathy which mimics type II

  19. Betydningen af deletionspolymorfi i ACE-genet for progression af ACE-haemmerbehandlet diabetisk nyresygdom

    DEFF Research Database (Denmark)

    Tarnow, L; Parving, H H; Jacobsen, P

    1998-01-01

    The aim of the study was to evaluate the effect of an insertion/deletion polymorphism of the angiotensin converting enzyme (ACE) gene on progression of diabetic nephropathy. We performed an observational follow-up study of 35 patients with insulin-dependent diabetes and diabetic nephropathy. Pati...

  20. Despotism and risk of infanticide influence grizzly bear den-site selection.

    Science.gov (United States)

    Libal, Nathan S; Belant, Jerrold L; Leopold, Bruce D; Wang, Guiming; Owen, Patricia A

    2011-01-01

    Given documented social dominance and intraspecific predation in bear populations, the ideal despotic distribution model and sex hypothesis of sexual segregation predict adult female grizzly bears (Ursus arctos) will avoid areas occupied by adult males to reduce risk of infanticide. Under ideal despotic distribution, juveniles should similarly avoid adult males to reduce predation risk. Den-site selection and use is an important component of grizzly bear ecology and may be influenced by multiple factors, including risk from conspecifics. To test the role of predation risk and the sex hypothesis of sexual segregation, we compared adult female (n = 142), adult male (n = 36), and juvenile (n = 35) den locations in Denali National Park and Preserve, Alaska, USA. We measured elevation, aspect, slope, and dominant land cover for each den site, and used maximum entropy modeling to determine which variables best predicted den sites. We identified the global model as the best-fitting model for adult female (area under curve (AUC) = 0.926) and elevation as the best predictive variable for adult male (AUC = 0.880) den sites. The model containing land cover and elevation best-predicted juvenile (AUC = 0.841) den sites. Adult females spatially segregated from adult males, with dens characterized by higher elevations (mean= 1,412 m, SE = 52) and steeper slopes (mean = 21.9°, SE = 1.1) than adult male (elevation: mean = 1,209 m, SE = 76; slope: mean = 15.6°, SE = 1.9) den sites. Juveniles used a broad range of landscape attributes but did not avoid adult male denning areas. Observed spatial segregation by adult females supports the sex hypothesis of sexual segregation and we suggest is a mechanism to reduce risk of infanticide. Den site selection of adult males is likely related to distribution of food resources during spring.

  1. Despotism and risk of infanticide influence grizzly bear den-site selection.

    Directory of Open Access Journals (Sweden)

    Nathan S Libal

    Full Text Available Given documented social dominance and intraspecific predation in bear populations, the ideal despotic distribution model and sex hypothesis of sexual segregation predict adult female grizzly bears (Ursus arctos will avoid areas occupied by adult males to reduce risk of infanticide. Under ideal despotic distribution, juveniles should similarly avoid adult males to reduce predation risk. Den-site selection and use is an important component of grizzly bear ecology and may be influenced by multiple factors, including risk from conspecifics. To test the role of predation risk and the sex hypothesis of sexual segregation, we compared adult female (n = 142, adult male (n = 36, and juvenile (n = 35 den locations in Denali National Park and Preserve, Alaska, USA. We measured elevation, aspect, slope, and dominant land cover for each den site, and used maximum entropy modeling to determine which variables best predicted den sites. We identified the global model as the best-fitting model for adult female (area under curve (AUC = 0.926 and elevation as the best predictive variable for adult male (AUC = 0.880 den sites. The model containing land cover and elevation best-predicted juvenile (AUC = 0.841 den sites. Adult females spatially segregated from adult males, with dens characterized by higher elevations (mean= 1,412 m, SE = 52 and steeper slopes (mean = 21.9°, SE = 1.1 than adult male (elevation: mean = 1,209 m, SE = 76; slope: mean = 15.6°, SE = 1.9 den sites. Juveniles used a broad range of landscape attributes but did not avoid adult male denning areas. Observed spatial segregation by adult females supports the sex hypothesis of sexual segregation and we suggest is a mechanism to reduce risk of infanticide. Den site selection of adult males is likely related to distribution of food resources during spring.

  2. A family with autosomal dominant mutilating neuropathy not linked to either Charcot-Marie-Tooth disease type 2B (CMT2B) or hereditary sensory neuropathy type I (HSN I) loci.

    Science.gov (United States)

    Bellone, Emilia; Rodolico, Carmelo; Toscano, Antonio; Di Maria, Emilio; Cassandrini, Denise; Pizzuti, Antonio; Pigullo, Simona; Mazzeo, Anna; Macaione, Vincenzo; Girlanda, Paolo; Vita, Giuseppe; Ajmar, Franco; Mandich, Paola

    2002-03-01

    Sensory loss and ulcero-mutilating features have been observed in hereditary sensory neuropathy type I and in hereditary motor and sensory neuropathy type IIB, also referred as Charcot-Marie-Tooth disease type 2B. To date two loci associated with ulcero-mutilating neuropathy have been described: CMT2B at 3q13-q22 and HSN I at 9q22.1-q22.3. We performed linkage analysis with chromosomal markers representing the hereditary sensory neuropathy type I and Charcot-Marie-Tooth disease type 2B loci on an Italian family with a severe distal sensory loss leading to an ulcero-mutilating peripheral neuropathy. Negative likelihood-of-odds scores excluded any evidence of linkage to both chromosome 3q13 and chromosome 9q22 markers, confirming the genetic heterogeneity of this clinical entity and the presence of a third locus responsible for ulcero-mutilating neuropathies.

  3. Heading for the hills: risk avoidance drives den site selection in African wild dogs.

    Science.gov (United States)

    Jackson, Craig R; Power, R John; Groom, Rosemary J; Masenga, Emmanuel H; Mjingo, Ernest E; Fyumagwa, Robert D; Røskaft, Eivin; Davies-Mostert, Harriet

    2014-01-01

    Compared to their main competitors, African wild dogs (Lycaon pictus) have inferior competitive abilities and interspecific competition is a serious fitness-limiting factor. Lions (Panthera leo) are the dominant large carnivore in African savannah ecosystems and wild dogs avoid them both spatially and temporally. Wild dog young are particularly vulnerable and suffer high rates of mortality from lions. Since lions do not utilize all parts of the landscape with an equal intensity, spatial variation in lion densities can be exploited by wild dogs both during their general ranging behaviour, but more specifically when they are confined to a den with vulnerable young. Since patches of rugged terrain are associated with lower lion densities, we hypothesized that these comparatively safe habitats should be selected by wild dogs for denning. We investigated the relationship between the distribution of 100 wild dog den sites and the occurrence of rugged terrain in four wild dog populations located in Tanzania, Zimbabwe and South Africa. A terrain ruggedness index was derived from a 90 m digital elevation model and used to map terrain ruggedness at each site. We compared characteristics of actual and potential (random) den sites to determine how wild dogs select den sites. The distributions of wild dog dens were strongly associated with rugged terrain and wild dogs actively selected terrain that was more rugged than that available on average. The likelihood of encountering lions is reduced in these habitats, minimizing the risk to both adults and pups. Our findings have important implications for the conservation management of the species, especially when assessing habitat suitability for potential reintroductions. The simple technique used to assess terrain ruggedness may be useful to investigate habitat suitability, and even predict highly suitable denning areas, across large landscapes.

  4. Heading for the hills: risk avoidance drives den site selection in African wild dogs.

    Directory of Open Access Journals (Sweden)

    Craig R Jackson

    Full Text Available Compared to their main competitors, African wild dogs (Lycaon pictus have inferior competitive abilities and interspecific competition is a serious fitness-limiting factor. Lions (Panthera leo are the dominant large carnivore in African savannah ecosystems and wild dogs avoid them both spatially and temporally. Wild dog young are particularly vulnerable and suffer high rates of mortality from lions. Since lions do not utilize all parts of the landscape with an equal intensity, spatial variation in lion densities can be exploited by wild dogs both during their general ranging behaviour, but more specifically when they are confined to a den with vulnerable young. Since patches of rugged terrain are associated with lower lion densities, we hypothesized that these comparatively safe habitats should be selected by wild dogs for denning. We investigated the relationship between the distribution of 100 wild dog den sites and the occurrence of rugged terrain in four wild dog populations located in Tanzania, Zimbabwe and South Africa. A terrain ruggedness index was derived from a 90 m digital elevation model and used to map terrain ruggedness at each site. We compared characteristics of actual and potential (random den sites to determine how wild dogs select den sites. The distributions of wild dog dens were strongly associated with rugged terrain and wild dogs actively selected terrain that was more rugged than that available on average. The likelihood of encountering lions is reduced in these habitats, minimizing the risk to both adults and pups. Our findings have important implications for the conservation management of the species, especially when assessing habitat suitability for potential reintroductions. The simple technique used to assess terrain ruggedness may be useful to investigate habitat suitability, and even predict highly suitable denning areas, across large landscapes.

  5. Cone-beam computed tomography for assessment of dens invaginatus in the Polish population.

    Science.gov (United States)

    Różyło, T Katarzyna; Różyło-Kalinowska, Ingrid; Piskórz, Magdalena

    2018-01-01

    There are many developmental variations in the permanent dentition. Dens invaginatus can be recognized on many dental X-rays of affected patients, but not every image allows for assessment of the type of malformation. The aim of the present study was to assess the presence of dens invaginatus with radiological features using cone-beam computed tomography (CBCT). CBCT images of 33 patients were evaluated. Age, sex, side, lateralization, occurrence in a particular group of teeth, type of invagination, differentiation, and the consequences of these factors were analyzed. Forty-one teeth with dens invaginatus met the inclusion criteria for this evaluation. Females were affected more frequently than males (57.6 vs. 42.4%, respectively). The patients' age ranged from 7 to 40 years, and the occurrence of dens invaginatus peaked from age 9 to 13 years. In total, 92.7% of affected teeth were present in the maxilla, more often unilaterally (75.8%) than bilaterally (24.2%). The most frequent tooth with dens invaginatus was the maxillary lateral incisor (53.7% of affected teeth). Almost two-thirds (63.4%) of affected teeth were found on the left side and 36.6% were found on the right. The tooth anatomy was distorted within the crown and root. Dens invaginatus sometimes affected other surrounding teeth and reduced their esthetics. The obtained data indicate that CBCT examination is an essential tool in assessing dens invaginatus and can guide dental practitioners in treating patients who exhibit characteristic features of this disorder. CBCT allows the clinician to distinguish the type of anomaly.

  6. Naturalismus als Herausforderung für den Religionsunterricht

    Directory of Open Access Journals (Sweden)

    Christian Feichtinger

    2015-11-01

    Full Text Available ENGLISH: This paper reflects on statements and attitudes of pupils in religion classes that represent a perspective of naturalism, and on teachers’ possibilities of reacting to such statements. We define the term ‘naturalism’ and explain, in which way naturalistic attitudes may occur and which questions they are related to. Based on a theological and philosophical criticism of naturalism we want to encourage teachers of religion to openly question such worldviews. To do so, we refer to the concept of ‘philosophy/theology for children/adolescents’. We argue to use the so-called ‘Socratic Method’ in its original sense, namely the challenging of alleged certainties (elenchus. The Socratic Method can and should be used not only to philosophize freely, but also to question pupils’ (naturalistic worldviews and attitudes, not with the purpose to then impose a ‘correct’ worldview onto them, but to help deconstructing alleged certainties and opening new horizons of thought. DEUTSCH: Der Beitrag befasst sich mit naturalistischen Aussagen und Einstellungen von SchülerInnen im Religionsunterricht und einer didaktischen Reflexion über den angemessenen Umgang mit ihnen durch die Lehrperson. Es wird dargelegt, was unter Naturalismus zu verstehen ist, auf welche Weise er im Unterricht auftauchen kann und welche Fragen davon betroffen sind. Gestützt auf eine theologisch-philosophische Kritik am Naturalismus sehen wir es als Aufgabe des Religionsunterrichts an, naturalistische Einstellungen kritisch zu hinterfragen. Hierzu beziehen wir uns auf das Konzept der ‚Kinder-/Jugendtheologie‘ bzw. im Speziellen auf eine ‚Theologie für Kinder/Jugendliche‘. Dabei plädieren wir dafür, die sog. ‚sokratische Methode‘ in ihrem ursprünglichen Sinn, nämlich der Infragestellung von vermeintlichen Gewissheiten (elenchus, zu verwenden. Die sokratische Methode kann und soll auch dafür verwendet werden, (naturalistische Weltsichten der Sch

  7. Brand management og den refleksive forbruger - med semiotik som hjælpedisciplin

    DEFF Research Database (Denmark)

    Hermansen, Judy

    2009-01-01

      Kritisk eftertanke er et væsentligt træk ved den refleksive forbruger - ofte parret med en vis negativitet overfor et brand, en reklame eller forbrugerisme i al almindelighed. Den refleksive forbrugertype kommer til udtryk hos for eksempel en anti-branding guru som Naomi Klein og hendes...... bestseller bog "No Logo" eller i græsrodsbevægelsen Adbusters ( https://www.adbusters.org/ ), der efterhånden i mange år har udsendt et månedsmagasin med kritik af forbrugersamfundet og al dets reklame og branding. Disse anti-forbrugs og anti-branding bevægelser udspringer af, og er identifikationspunkter...... - den refleksive forbruger skal have noget, der kan "brande" ham som anderledes end alle mainstreamforbrugerne. Den refleksive forbruger er med andre ord en Feinschmecker og i lighed med - eller måske rettere i endnu højere grad end - alle andre forbrugere signalerer den refleksive forbruger sin...

  8. Vrouekarakters in enkele prosawerke van C.M. van den Heever

    Directory of Open Access Journals (Sweden)

    E. Botha

    2003-08-01

    Full Text Available The role of women in some prose works of C.M. van den Heever Re-reading the C.M. van den Heever “classics” Somer (1935 and Laat vrugte (1939 within the framework of Van den Heever criticism through the years, one becomes aware that central themes in his oeuvre are acted out by women. The beautiful young girl Linda in Somer embodies the sadness of the transcience of beauty and happiness. Through Ouma Willa, Betta and Johanna – three women from three generations in Laat vrugte – the theme of the endurance of the memory of love and passion beyond decay and death is expressed. A cursory examination of other and earlier works by Van den Heever – Op die plaas (1927, Langs die grootpad (1928, Kromburg (1937 and the short story “Leuens” (Lies from Vuurvlieg en sterre (1934 – bears out the observation that women express core meanings in C.M. van den Heever’s prose works.

  9. En referenceramme til analyse af en detailkæde og strukturen i dens branche

    DEFF Research Database (Denmark)

    Skytte, Hans

    2001-01-01

    identitet, dens opfattelser og fortolkning af mar-kedet og konkurrencesituationen, samt relationer over til dens strukturer, sortiment og salgsadfærd. Analysen vil kunne gennemføres på et bestemt tidspunkt og således give et øjebliksbillede af en detailkæde, eller den kan gennemføres flere på hinanden...... følgende gange, hvorved man kan opnå en analyse af sammenhænge i udviklingen i de faktorer, der indgår i analysen. Ved udviklingen af analyserammen er der tænkt på en europæisk fødevaredetailkæde, men rammen kan lige så godt anvendes på en detailkæde, der distribuerer modetøj eller møbler. Analyserammen...

  10. Optimal matching of energy supply and demand; Optimale Anpassung der Energiebereitstellung an den Bedarf

    Energy Technology Data Exchange (ETDEWEB)

    Baumgarth, S. [Competence Center for Building Networks in Wolfenbuettel (Germany); Boggasch, E.; Heiser, M.; Schernus, G.P. [Fachhochschule Braunschweig/Wolfenbuettel (Germany)

    2004-06-01

    New strategies are presented for matching heat supply and demand on the basis of a bus technology. Investment costs are at a minimum as the automation stations are activated by introducing new programs. (orig.) [German] Seit einiger Zeit wird ueber verschiedene Regelungsstrategien versucht, die Energiebereitstellung so an den Bedarf (Verbraucher) anzupassen, dass die Waermeverluste beim Transport auf den Zuleitungen sowie in der Energiezentrale minimiert werden. Fuer mehrere Anwendungen aus dem Bereich der Heizungs-, Lueftungs- und Klimatechnik sollen hier neue Strategien vorgestellt werden, die erst mit dem Einsatz der Bus-Technologien in der Gebaeudeautomation moeglich sind. Fuer die Betrachtungen ist es auch von Wichtigkeit, dass zu deren Umsetzung moeglichst keine zusaetzlichen Investitionskosten erforderlich sind, sondern dass die in den Automationsstationen durch Einfuegen neuer Programme zu aktivieren sind. (orig.)

  11. Multifaktormodeller på den svenska marknaden - En studie av OMX Stockholm mellan 1996 och 2014

    OpenAIRE

    Hammarfrid, Peter; Henningsson, Tom

    2015-01-01

    Bakgrund:CAPM räcker i flera tillfällen inte till för att estimera framtida avkastning. Vissa av prisavvikelsernafrån CAPM är väldokumenterade och har bestått över tid, vilket har lett till uppkomsten avkorrigerande faktorer. En modell som använder sig av två sådana korrigerande faktorer är Fama ochFrenchs tre-faktormodell. Den har testats flertalet gånger på den svenska marknaden där den visat gehögre förklaringsgrader än CAPM. År 2012 samt år 2014 presenterades två nya multifaktormodeller,s...

  12. Mapping polar bear maternal denning habitat in the National Petroleum Reserve -- Alaska with an IfSAR digital terrain model

    Science.gov (United States)

    Durner, George M.; Simac, Kristin S.; Amstrup, Steven C.

    2013-01-01

    The National Petroleum Reserve–Alaska (NPR-A) in northeastern Alaska provides winter maternal denning habitat for polar bears (Ursus maritimus) and also has high potential for recoverable hydrocarbons. Denning polar bears exposed to human activities may abandon their dens before their young are able to survive the severity of Arctic winter weather. To ensure that wintertime petroleum activities do not threaten polar bears, managers need to know the distribution of landscape features in which maternal dens are likely to occur. Here, we present a map of potential denning habitat within the NPR-A. We used a fine-grain digital elevation model derived from Interferometric Synthetic Aperture Radar (IfSAR) to generate a map of putative denning habitat. We then tested the map’s ability to identify polar bear denning habitat on the landscape. Our final map correctly identified 82% of denning habitat estimated to be within the NPR-A. Mapped denning habitat comprised 19.7 km2 (0.1% of the study area) and was widely dispersed. Though mapping denning habitat with IfSAR data was as effective as mapping with the photogrammetric methods used for other regions of the Alaskan Arctic coastal plain, the use of GIS to analyze IfSAR data allowed greater objectivity and flexibility with less manual labor. Analytical advantages and performance equivalent to that of manual cartographic methods suggest that the use of IfSAR data to identify polar bear maternal denning habitat is a better management tool in the NPR-A and wherever such data may be available.

  13. Frecuencia del alelo causante de la enfermedad de Charcot-Marie-Tooth (tipo axonal con herencia autosómica recesiva en Palmares, Costa Rica

    Directory of Open Access Journals (Sweden)

    Melissa Rojas-Araya

    2009-11-01

    Full Text Available La enfermedad de Charcot-Marie-Tooth constituye elgrupo de neuropatías periféricas hereditarias más común a nivel mundial. Una familia con 18 afectados del cantón de Palmares (Alajuela, Costa Rica con una neuropatía de tipo axonal y herencia autosómica recesiva, permitió localizar el gen responsable en la región 19q13.33. Posteriormente se identificó la mutación causante en el gen MED25. El presente estudio determinó la frecuencia del alelo mutante, así como la distribución geográfica de este alelo. En una muestra al azar de 103 individuos se encontraron seis individuos heteroigotas para la mutación, distribuidos por todo el cantón. No se encontró ninguna persona en estado homocigota para este alelo. No hallamos algunacaracterística clínica que difiera significativamente entre los individuos homocigotos silvestres y los heterocigotos para la mutación. El 5.83% de la población es heterocigota y la frecuencia del alelo Ala335Val es de 0.029, seis veces mayor que en una muestra de toda la población costarricense. Por esta razón se recomienda un análisis molecular de portadores con el fin de alertar sobre la posibilidad de aparición de más casos en el cantón.Frecuency of the allele causing the axonal form of autosomal recessive Charcot-Marie-Tooth in Palmares, Costa Rica. The Charcot-Marie-Tooth disease constitutes is among the most frequent hereditary peripheral neuropathies world-wide. We identified a family from Palmares (Alajuela, Costa Rica with 18 affected members. Their neuropathy is axonal, with an autosomal recessive pattern of inheritance; the responsible gene is at the 19q13.33 chromosomal region. Later the mutation was identified in gene MED25. We studied the frequency and geographic distribution of the mutant allele. In a random sample of 103 individuals, six were heterozygote and were widely distributed in Palmares. There was no person in homozigote state for the mutant allele. Clinical characteristics do

  14. Hvordan håndteres den nødvendige distribution af digital bevaring?

    DEFF Research Database (Denmark)

    Zierau, Eld

    2014-01-01

    Distribueret digital bevaring er nødvendig, men også tit vanskelig, især når flere organisationer er involveret. En referenceramme kan bistå til forståelse, opbygning og tjek af distribueret digital bevaring, så tilliden til den digitale bevaring opretholdes......Distribueret digital bevaring er nødvendig, men også tit vanskelig, især når flere organisationer er involveret. En referenceramme kan bistå til forståelse, opbygning og tjek af distribueret digital bevaring, så tilliden til den digitale bevaring opretholdes...

  15. Calibration of radioprotection equipment gamma radiation at the Laboratory of Ionizing Radiation Metrology - DEN/UFPE

    International Nuclear Information System (INIS)

    Nazario, Macilene; Khoury, Helen; Hazin, Clovis

    2003-01-01

    This work presents aspects of the radioprotection equipment calibration service of the Laboratory for Metrology of Ionizing Radiations (LMRI) of the DEN/UFPE related to the calibration procedures, characteristics of the radiation beam and the evaluation of equipment calibrated in the period of 2001-2002. The LMRI-DEN/UFPE is one of the four laboratories in Brazil licensed by the Brazilian Nuclear Energy Commission for the execution of calibration services on area, surface contamination and personal monitors used by industries, hospitals, universities and research institutes using radioactive sources

  16. Zahraniční publicistika časopisu Týden

    OpenAIRE

    Dvořáková, Zdenka

    2010-01-01

    The bachelor thesis "Foreign publicism of the Týden Magazine" cleals with publicistic texts with foreign topics published in the Týden Magazine. It tries to narned the genre (gloss, comment, editorial and column), which the first part of the thesis acts. This part clescribc s, how these genres should be written according to technicalliteraturc. The second part dwells on the main intent of the thesis, namely the measure of keeping these c1efinitions by authors. It also looks how they these gen...

  17. Demokratisk forum eller fallit: Valgkamp i den lokale avis set gennem en lingvistisk lup

    OpenAIRE

    Frederiksen, Line

    2007-01-01

    Denne specialeafhandling undersøger indholdet af DAGBLADET Roskildes artikler om den kom-munale valgkamp i 1997, 2001 og 2005 i de tre dage før, under og efter valget. Formålet med un-dersøgelsen er at dokumentere, hvilke overordnede temaer, der ligger i teksterne og efterfølgende ridse de demokratiske konsekvenser af tematiseringen op i forhold til læserne af DAGBLADET. I dansk kontekst udgør undersøgelsesperioden, hvad Pippa Norris definerer som ’den postmo-derne fase’ i politisk kommunikat...

  18. Kommunen er død - længe leve den digitale disruption

    DEFF Research Database (Denmark)

    Andersen, Kim Normann

    2017-01-01

    "New Public Management is Dead. Long Live the Digital Era." Sådan proklamerede Patrick Donleavy digitaliseringens muligheder i en banebrydende artikel fra 2005. Med en omskrivning af dette citat til "Kommunen er død, længe leve den digitale disruption", er ballet åbnet for denne artikel......."New Public Management is Dead. Long Live the Digital Era." Sådan proklamerede Patrick Donleavy digitaliseringens muligheder i en banebrydende artikel fra 2005. Med en omskrivning af dette citat til "Kommunen er død, længe leve den digitale disruption", er ballet åbnet for denne artikel....

  19. Co-occurrence of gemination and dens invaginatus: a case report

    Directory of Open Access Journals (Sweden)

    Sonika Achalli

    2016-03-01

    Full Text Available Gemination is a developmental anomaly where a single tooth bud attempts to split into two. It is also sometimes called as double tooth or twinning. Dens invaginatus is another developmental anomaly caused due to invagination of a portion of crown. These anomalies occur as separate entities. Co-occurrence of these two anomalies have been only reported four times in the literature. Here we present an extremely rare case of simultaneous occurrence of gemination and dens invaginatus in the same tooth. [Cukurova Med J 2016; 41(1.000: 175-177

  20. den pakotettu käyttö : vaikuttava aivohalvauspotilaan kuntoutusmenetelmä

    OpenAIRE

    Hänninen, Kati; Näsi, Minna

    2007-01-01

    Opinnäytetyön tarkoituksena oli käsitellä käden pakotettua käyttöä aivohalvauspotilaan kuntoutusmenetelmänä ja tuoda esille sen vaikuttavuutta halvaantuneen yläraajan toimintakyvyn edistämisen kannalta. Tavoitteena oli kirjallisuuskatsauksen ja tapausesimerkin avulla luoda kattava kokonaisuus käden pakotetun käytön kuntoutuksesta. Lähdeaineistona käytettiin uusimpia aiheeseen liittyviä tutkimuksia, monipuolista kirjallisuutta sekä tapausesimerkin henkilökohtaisia tiedonantoja. Opinnäytetyössä...

  1. Sustained Expression of Negative Regulators of Myelination Protects Schwann Cells from Dysmyelination in a Charcot-Marie-Tooth 1B Mouse Model.

    Science.gov (United States)

    Florio, Francesca; Ferri, Cinzia; Scapin, Cristina; Feltri, M Laura; Wrabetz, Lawrence; D'Antonio, Maurizio

    2018-05-02

    Schwann cell differentiation and myelination in the PNS are the result of fine-tuning of positive and negative transcriptional regulators. As myelination starts, negative regulators are downregulated, whereas positive ones are upregulated. Fully differentiated Schwann cells maintain an extraordinary plasticity and can transdifferentiate into "repair" Schwann cells after nerve injury. Reactivation of negative regulators of myelination is essential to generate repair Schwann cells. Negative regulators have also been implicated in demyelinating neuropathies, although their role in disease remains elusive. Here, we used a mouse model of Charcot-Marie-Tooth neuropathy type 1B (CMT1B), the P0S63del mouse characterized by ER stress and the activation of the unfolded protein response, to show that adult Schwann cells are in a partial differentiation state because they overexpress transcription factors that are normally expressed only before myelination. We provide evidence that two of these factors, Sox2 and Id2, act as negative regulators of myelination in vivo However, their sustained expression in neuropathy is protective because ablation of Sox2 or/and Id2 from S63del mice of both sexes results in worsening of the dysmyelinating phenotype. This is accompanied by increased levels of mutant P0 expression and exacerbation of ER stress, suggesting that limited differentiation may represent a novel adaptive mechanism through which Schwann cells counter the toxic effect of a mutant terminal differentiation protein. SIGNIFICANCE STATEMENT In many neuropathies, Schwann cells express high levels of early differentiation genes, but the significance of these altered expression remained unclear. Because many of these factors may act as negative regulators of myelination, it was suggested that their misexpression could contribute to dysmyelination. Here, we show that the transcription factors Sox2 and Id2 act as negative regulators of myelination in vivo , but that their sustained

  2. EU er på vej mod at udvikle og implementere europæiske regnskabsstandarder indenfor den offentlige sektor

    DEFF Research Database (Denmark)

    Pontoppidan, Caroline Aggestam

    2015-01-01

    I maj 2013 var Europa-Kommisionen og Eurostat vært for en konference med formålet at forhandle om den fremtidige udvikling af harmoniserede offentlige regnskabsstandarder ('European Public Sector Accounting Standards' EPSAS) som skal anvendes af alle medlemslande i den Europæiske Union...

  3. Raccoon Use of Den Trees and Plant Associations in Western Mesophytic Forests: Tree Attributes and Availability or Landscape Heterogeneity?

    Science.gov (United States)

    Winston P. Smith; Keith M. Endres

    2012-01-01

    We monitored 15 radio-collared raccoons (Procyon lotor) on Davies Island in March 1987 - May 1988 to determine the extent to which individual tree attributes or spatial configuration of plant associations (habitat types) across the land-scape influenced den use. Of 1091 verified den sites, 428 were in tree cavities. Raccoon occurrence among 4 cover...

  4. Enhancement of ultraviolet-DNA repair in denV gene transfectants and T4 endonuclease V-liposome recipients

    International Nuclear Information System (INIS)

    Kibitel, J.T.; Yee, V.; Yarosh, D.B.

    1991-01-01

    The phage T4 denV gene, coding for the pyrimidine-dimer specific T4 endonuclease V, was transfected into human repair-proficient fibroblasts, repair-deficient xeroderma pigmentosum fibroblasts, and wild type CHO hamster cells. Transfectants maintained denV DNA and expressed denV mRNA. Purified T4 endonuclease V encapsulated in liposomes was also used to treat repair-proficient and -deficient human cells. The denV transfected clones and liposome-treated cells showed increased unscheduled DNA synthesis and enhanced removal of pyrimidine dimers compared to controls. Both denV gene transfection and endonuclease V liposome treatment enhanced post-UV survival in xeroderma pigmentosum cells but had no effect on survival in repair-proficient human or hamster cells. The results demonstrate that an exogenous DNA repair enzyme can correct the DNA repair defect in xeroderma pigmentosum cells and enhance DNA repair in normal cells. (author)

  5. Metoder til den børnefaglige undersøgelse

    DEFF Research Database (Denmark)

    Sørensen, Kresta Munkholt

    Denne afhandling omhandler rammerne for sagsbehandlingen i forhold til udsatte børn, unge og deres familier. Afhandlingen er centreret omkring, hvordan socialarbejderne oplever metoderne til den børnefaglige undersøgelse, og er udarbejdet i et komparativt perspektiv med fokus på følgende tre...

  6. Når mobilen tager magten - nærvær i den digitale tidsalter

    DEFF Research Database (Denmark)

    Fenger, Morten Munthe

    at se ind i en skærm? "Når mobilen tager magten" beskriver, hvordan den digitale teknologi og sociale medier såsom Facebook, Instagram og Snapchat går direkte ind og udnytter menneskets instikter, og tilfredsstiller vores behov hurtigere end vores forstand og vilje kan følge med og sige fra. "Når...

  7. Over den invloed van insuline op de permeabiliteit der weefsels voor glucose

    NARCIS (Netherlands)

    Hamburger, Rudolf Jacobus

    1930-01-01

    In het voorafgaande overzicht van de literatuur, hebben wij gezien, dat vooral vele proeven in vivo, erop wijzen, dat bij diabetes, zoowel van den mensch als bij door pancreasextirpatie diabetisch gemaakte proefdieren minder glucose in de weefsels voorkomt en eveneens minder glucose daarin wordt

  8. Endline report – Liberia, DEN-L MFS II country evaluations

    NARCIS (Netherlands)

    Gotomo, S.; Peters, B.; Kusters, C.S.L.; Peabody, S.; Washington Gopeya, M.

    2015-01-01

    This report presents the findings of the endline of the evaluation of the organisational capacity component of the MFS II country evaluations. The focus of this report is Liberia, DEN-L. The format is based on the requirements by the synthesis team and NWO/WOTRO. The endline was carried out in 2014.

  9. Threatened fishes of the world: Coptodon walteri (Thys van den Audenaerde 1968 (Perciformes: Cichlidae

    Directory of Open Access Journals (Sweden)

    Konan Felix Koffi

    2016-06-01

    Full Text Available Coptodon walteri Thys van den Audenaerde 1968, an endemic cichlid of Ivory Coast and Liberia, is assessed as Near Threatened due to fishing pressure and loss of habitats, and aquatic pollution as a result of extensive clandestine gold mining in the bed of the Cavally River. There is an immediate need for developing conservation and management plans for this species.

  10. Store daginstitutioner og deres betydning for den pædagogiske dagligdag

    DEFF Research Database (Denmark)

    Gammelby, Marie Louise; Brandi-Hansen, Sissel

    2014-01-01

    Forfatterne søger at afdække, hvilken betydning nye store daginstitutioner har for de mulighedsbetingelser, der opstilles for dels den pædagogiske praksis og, som en konsekvens heraf, dels for børns udfoldelsesmuligheder....

  11. HIV-surveys bij hoog-risicogroepen in Den Haag 2005

    NARCIS (Netherlands)

    Veen MG van; Wagemans MAJ; Burg I van den; Tonino-van der Marel E; Leeuwen AP van; Laar MJW van de; CIE

    2006-01-01

    Verspreiding van HIV en SOA kan mogelijk optreden doordat hoog-risicogroepen een brug vormen naar de rest van de bevolking in Nederland. Dit blijkt uit de HIV-survey die is uitgevoerd in Den Haag onder prostituees werkzaam in de raamprostitutie, clubs en op de tippelzone en onder migranten

  12. Den vitalistiske strømning i dansk litteratur omkring år 1900

    DEFF Research Database (Denmark)

    Dam, Anders Ehlers

    nylæsninger deres værker i spil med århundredskiftets billedkunst og musik, repræsenteret af J.F. Willumsen og Carl Nielsen. Den livsdyrkende kunst i Danmark sættes desuden ind i sin internationale idéhistoriske sammenhæng. Her er de tyske filosoffer Arthur Schopenhauer og Friedrich Nietzsche i fokus....

  13. [Heinz von zur Mühlen. Auf den Spuren einiger revlaer Firmen und Familien] / Paul Kaegbein

    Index Scriptorium Estoniae

    Kaegbein, Paul

    2007-01-01

    Arvustus: Heinz von zur Mühlen. Auf den Spuren einiger revlaer Firmen und Familien. In : Buch und Bildung im Baltikum. Münster : LIT, 2005, lk. 527-541. Pika tänava majade omanikest alates 17. sajandist - perekonnad Koch, Meyer, Kluge, Ströhm, Wassermann, Glehn, Eggers, Koppelson, Weiss. Nii loob autor pildi Tallinna "firmade ajaloost"

  14. Dansk international landevejstransport - en branche og dens forening i konstant udvikling

    DEFF Research Database (Denmark)

    Klatt, Martin

    Festskrift til interesseorganisationen International Transport Danmarks 60-års jubilæum. Bogen fortæller, hvordan foreningen FDE/ITD og dens medlemmer siden 1980'erne har tilpasset sig de ændrede vilkår på transportmarkederne. Bogen redegør for liberaliseringen af EU's transportmarked...

  15. Tussen de mazen van het net : drie Poolse mannen in Den Haag aan het woord

    NARCIS (Netherlands)

    Karijn Nijhoff

    In deze publicatie staan de verhalen van drie Poolse mannen in Den Haag centraal. De onderzoeker, Karijn Nijhoff, heeft zeer intensief deze mannen gevolgd en hun verhalen opgetekend. We lezen over aankomst, vertrek en terugkomst. We zien een grillig proces van werken en niet werken, klussen en

  16. Bliv en bedre investor med overblik over den globale økonomi

    DEFF Research Database (Denmark)

    Risager, Ole

    2012-01-01

    Fremgangen i den globale økonomi og de nye tiltag i euroområdet har fået optimismen til at spire på aktiemarkederne. Ole Risager, professor på CBS, giver dig her overblikket over, hvordan økonomien på verdensmarkedet ser ud lige nu, og hvordan du - med denne indsigt - placerer dine sparepenge bed...

  17. Udbredelse af den baktielle zoonose i danske kvægbesætninger

    DEFF Research Database (Denmark)

    Bødker, Rene; Christoffersen, Anna-Bodil

    2008-01-01

    Tankmælksprøver fra 742 mælkeleverende kvægejendomme blev analyseret for antistoffer mod Coxiella burnetii i en ELISA. 57% af ejendommene havde positive prøver i den serologiske test. Prøverne var diagnostiske indsendelser til DTU Veterinærinstituttet og udgjorde derfor ikke en repræsentativ...

  18. Kvantitative metoder og den globale fattigdomsmålsætning

    DEFF Research Database (Denmark)

    Casse, Thorkil

    2007-01-01

    Artiklen problematiserer den model (kun økonomisk vækst), som internationale organisationer anvender, når det skal forklares, hvordan fattigdomme halveres. Måske ved relativ få, trods ofte anvendelse, hvad begrebet fattigdomsorienteret vækst indbefatter. Artiklen fokuserer primært på PRSP (Povert...... Reduction Strategy Papers) i Burkina Faso og Madagascar....

  19. Johannes van den Berg, Constrained by Jesus' Love. An Inquiry into ...

    African Journals Online (AJOL)

    Johannes van den Berg, Constrained by Jesus' Love. An Inquiry into the Motives of the missionary Awakening in Qreat Britain in the Period between 1698 and 1815, J. H. Kok, N.V., Kampen, 1956. P.S Dreyer. Abstract. No Abstract. Full Text: EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT ...

  20. Den danske FN-aktivismes storhed og fald 1945-2016

    DEFF Research Database (Denmark)

    Jakobsen, Peter Viggo; Kjærsgaard, Kristine

    2017-01-01

    Traktat Organisation (NATO) og amerikansk-ledede koalitioner. De store skift i den danske FN aktivisme i perioden 1945-2016 analyseres i tre domæner: diplomati, økonomi og militær ved hjælp af fire indikatorer: frivillighed, initiativrigdom, risikovillighed og ressourceforbrug. FN’s aktivismens storhed og...

  1. Surgical Orthodontic Treatment of an Impacted Canine in the Presence of Dens Invaginatus and Follicular Cyst

    Science.gov (United States)

    Canevello, Carola; Laffi, Nicola

    2014-01-01

    Introduction. “Dens invaginatus” is a dental anomaly which originates from the invagination of the ameloblastic epithelium into the lingual surface of the dental crown during the odontogenesis. It can cause early pulpal necrosis, abscesses, retention or dislocation of contiguous elements, cysts, and internal resorptions. It normally affects the upper lateral incisors. In the following study the authors will discuss the etiology, the physiopathology, and the surgical-orthodontic management of a rare case of impacted canine associated with dens invaginatus and follicular cyst, with the aim of highlighting the importance of taking any therapeutic decision based on the data available in the literature. Case Report. The present study describes a combined surgical-orthodontic treatment of an impacted canine associated with a lateral incisor (2.2) suffering from type III dens invaginatus with radicular cyst, in a 15-year-old patient. Discussion. When treating a dens invaginatus there are different therapeutic solutions: they depend on the gravity of the anomaly and on the association with the retention of a permanent tooth. The aesthetic and functional restoration becomes extremely important when performing a surgical-orthodontic repositioning. PMID:24963421

  2. Von den Liven von Oesel / August Ludwig Schlözer

    Index Scriptorium Estoniae

    Schlözer, August Ludwig

    2008-01-01

    Avaldatud Eberhard Winkleri initsiatiivil A. L. Schlözeri teose põhjal: Gesammelte Nachrichten von den Ueberresten der Liven, in Livland und Kurland. (1770), mis moodustab osa teosest: Schlözer, August Ludwig. M. Johann Joseph Haigold's Beylagen zum Neuveränderten Russland. Zweiter Theil. Riga und Leipzig, 1770

  3. Synet på døden i Grundtvigs gendigtninger af gammeltestamentlige tekster

    DEFF Research Database (Denmark)

    Nielsen, Kirsten

    2013-01-01

    i den gammelnordiske betydning: dødsriget. Resultatet bliver, at Grundtvig, der ellers ikke er tilbageholdende med at tale om Djævelen og Helvede, kun meget sjældent gør det, når han gendigter en gammeltestamentlig tekst. Grundtvig er således loyal over for sit gammeltestamentlige forlæg, hvilket...

  4. Forskningsbibliotekerne får travlt, hvis den nationale Open Access strategi skal lykkes

    DEFF Research Database (Denmark)

    Ibanez, Karen Sofie Hytteballe; Sandfær, Anne

    2014-01-01

    Med nedsættelsen af en national styregruppe for Open Access (OA) ser der endelig ud til at ske noget på den front i Danmark. Uddannelses og Forskningsministeriet har, efter at have anbefalinger liggende i skuffen i flere år, nu endelig meldt en national strategi ud. Målet er 80% grøn OA i 2017 og...

  5. The Dens: Normal Development, Developmental Variants and Anomalies, and Traumatic Injuries

    Directory of Open Access Journals (Sweden)

    William T O′Brien

    2015-01-01

    Full Text Available Accurate interpretation of cervical spine imagining can be challenging, especially in children and the elderly. The biomechanics of the developing pediatric spine and age-related degenerative changes predispose these patient populations to injuries centered at the craniocervical junction. In addition, congenital anomalies are common in this region, especially those associated with the axis/dens, due to its complexity in terms of development compared to other vertebral levels. The most common congenital variations of the dens include the os odontoideum and a persistent ossiculum terminale. At times, it is necessary to distinguish normal development, developmental variants, and developmental anomalies from traumatic injuries in the setting of acute traumatic injury. Key imaging features are useful to differentiate between traumatic fractures and normal or variant anatomy acutely; however, the radiologist must first have a basic understanding of the spectrum of normal developmental anatomy and its anatomic variations in order to make an accurate assessment. This review article attempts to provide the basic framework required for accurate interpretation of cervical spine imaging with a focus on the dens, specifically covering the normal development and ossification of the dens, common congenital variants and their various imaging appearances, fracture classifications, imaging appearances, and treatment options.

  6. Kvinden, diakonissen og sygeplejersken i Den danske Diakonissestiftelses etableringsfase 1863-1873

    DEFF Research Database (Denmark)

    Lauritzen, Jette

    and nurse in the establishing phase of `Den danske Diakonissestiftelse`, from 1863 to 1873, was partially culturally unacceptable and not culturally recognisable for the bourgeoisie. This meant that the deaconesses had to fight on all fronts to gain recognition and the possibility to further the cause...

  7. Kvinden, diakonissen og sygeplejersken i Den danske Diakonissestiftelses etableringsfase 1863-1873

    DEFF Research Database (Denmark)

    Lauritzen, Jette

    2005-01-01

    and nurse in the establishing phase of `Den danske Diakonissestiftelse`, from 1863 to 1873, was partially culturally unacceptable and not culturally recognisable for the bourgeoisie. This meant that the deaconesses had to fight on all fronts to gain recognition and the possibility to further the cause...

  8. Når logopæden hører stemmer

    DEFF Research Database (Denmark)

    Iwarsson, Jenny

    2011-01-01

    Da jeg for leden henvendte mig til et bilværksted på Amager og gav en kort beskrivelse af den foruroligende lyd jeg registreret i min bil, svarede bilmekanikeren hurtigt, at det med stor sandsynlighed var tale om et kuglelager i venstre forhjul der skulle skiftes. Efter en kort prøvetur hvor meka...

  9. DenHunt - A Comprehensive Database of the Intricate Network of Dengue-Human Interactions.

    Directory of Open Access Journals (Sweden)

    Prashanthi Karyala

    2016-09-01

    Full Text Available Dengue virus (DENV is a human pathogen and its etiology has been widely established. There are many interactions between DENV and human proteins that have been reported in literature. However, no publicly accessible resource for efficiently retrieving the information is yet available. In this study, we mined all publicly available dengue-human interactions that have been reported in the literature into a database called DenHunt. We retrieved 682 direct interactions of human proteins with dengue viral components, 382 indirect interactions and 4120 differentially expressed human genes in dengue infected cell lines and patients. We have illustrated the importance of DenHunt by mapping the dengue-human interactions on to the host interactome and observed that the virus targets multiple host functional complexes of important cellular processes such as metabolism, immune system and signaling pathways suggesting a potential role of these interactions in viral pathogenesis. We also observed that 7 percent of the dengue virus interacting human proteins are also associated with other infectious and non-infectious diseases. Finally, the understanding that comes from such analyses could be used to design better strategies to counteract the diseases caused by dengue virus. The whole dataset has been catalogued in a searchable database, called DenHunt (http://proline.biochem.iisc.ernet.in/DenHunt/.

  10. DenHunt - A Comprehensive Database of the Intricate Network of Dengue-Human Interactions.

    Science.gov (United States)

    Karyala, Prashanthi; Metri, Rahul; Bathula, Christopher; Yelamanchi, Syam K; Sahoo, Lipika; Arjunan, Selvam; Sastri, Narayan P; Chandra, Nagasuma

    2016-09-01

    Dengue virus (DENV) is a human pathogen and its etiology has been widely established. There are many interactions between DENV and human proteins that have been reported in literature. However, no publicly accessible resource for efficiently retrieving the information is yet available. In this study, we mined all publicly available dengue-human interactions that have been reported in the literature into a database called DenHunt. We retrieved 682 direct interactions of human proteins with dengue viral components, 382 indirect interactions and 4120 differentially expressed human genes in dengue infected cell lines and patients. We have illustrated the importance of DenHunt by mapping the dengue-human interactions on to the host interactome and observed that the virus targets multiple host functional complexes of important cellular processes such as metabolism, immune system and signaling pathways suggesting a potential role of these interactions in viral pathogenesis. We also observed that 7 percent of the dengue virus interacting human proteins are also associated with other infectious and non-infectious diseases. Finally, the understanding that comes from such analyses could be used to design better strategies to counteract the diseases caused by dengue virus. The whole dataset has been catalogued in a searchable database, called DenHunt (http://proline.biochem.iisc.ernet.in/DenHunt/).

  11. A brief review of recent Charcot-Marie-Tooth research and priorities [v1; ref status: indexed, http://f1000r.es/53g

    Directory of Open Access Journals (Sweden)

    Sean Ekins

    2015-02-01

    Full Text Available This brief review of current research progress on Charcot-Marie-Tooth (CMT disease is a summary of discussions initiated at the Hereditary Neuropathy Foundation (HNF scientific advisory board meeting on November 7, 2014. It covers recent published and unpublished in vitro and in vivo research. We discuss recent promising preclinical work for CMT1A, the development of new biomarkers, the characterization of different animal models, and the analysis of the frequency of gene mutations in patients with CMT. We also describe how progress in related fields may benefit CMT therapeutic development, including the potential of gene therapy and stem cell research. We also discuss the potential to assess and improve the quality of life of CMT patients. This summary of CMT research identifies some of the gaps which may have an impact on upcoming clinical trials. We provide some priorities for CMT research and areas which HNF can support. The goal of this review is to inform the scientific community about ongoing research and to avoid unnecessary overlap, while also highlighting areas ripe for further investigation. The general collaborative approach we have taken may be useful for other rare neurological diseases.

  12. Genetics of the Charcot-Marie-Tooth disease in the Spanish Gypsy population: the hereditary motor and sensory neuropathy-Russe in depth.

    Science.gov (United States)

    Sevilla, T; Martínez-Rubio, D; Márquez, C; Paradas, C; Colomer, J; Jaijo, T; Millán, J M; Palau, F; Espinós, C

    2013-06-01

    Four private mutations responsible for three forms demyelinating of Charcot-Marie-Tooth (CMT) or hereditary motor and sensory neuropathy (HMSN) have been associated with the Gypsy population: the NDRG1 p.R148X in CMT type 4D (CMT4D/HMSN-Lom); p.C737_P738delinsX and p.R1109X mutations in the SH3TC2 gene (CMT4C); and a G>C change in a novel alternative untranslated exon in the HK1 gene causative of CMT4G (CMT4G/HMSN-Russe). Here we address the findings of a genetic study of 29 Gypsy Spanish families with autosomal recessive demyelinating CMT. The most frequent form is CMT4C (57.14%), followed by HMSN-Russe (25%) and HMSN-Lom (17.86%). The relevant frequency of HMSN-Russe has allowed us to investigate in depth the genetics and the associated clinical symptoms of this CMT form. HMSN-Russe probands share the same haplotype confirming that the HK1 g.9712G>C is a founder mutation, which arrived in Spain around the end of the 18th century. The clinical picture of HMSN-Russe is a progressive CMT disorder leading to severe weakness of the lower limbs and prominent distal sensory loss. Motor nerve conduction velocity was in the demyelinating or intermediate range. © 2012 John Wiley & Sons A/S.

  13. MRI findings, patterns of disease distribution, and muscle fat fraction calculation in five patients with Charcot-Marie-Tooth type 2 F disease

    Energy Technology Data Exchange (ETDEWEB)

    Gaeta, Michele; Mileto, Achille; Minutoli, Fabio; Settineri, Nicola; Donato, Rocco; Ascenti, Giorgio; Blandino, Alfredo [Policlinico ' ' G. Martino' ' , Dipartimento di Scienze Radiologiche, Messina (Italy); Mazzeo, Anna; Di Leo, Rita [Policlinico ' ' G. Martino' ' , Dipartimento di Neuroscienze, Scienze Psichiatriche ed Anestesiologiche, Messina (Italy)

    2012-05-15

    To describe the magnetic resonance imaging (MRI) pattern of muscle involvement and disease progression in five patients with late-onset Charcot-Marie-Tooth (CMT) disease type 2 F, due to a previously unknown mutation. Five patients (three males, two females) underwent MRI of the lower limbs to define the pattern of muscle involvement and evaluate the muscle fat fraction (MFF) of residual thigh muscle with gradient-echo (GRE) dual-echo dual-flip angle technique. Evaluation of fatty infiltration both by visual inspection and MFF calculation was performed. A proximal-to-distal gradient of muscle involvement was depicted in male patients with extensive muscle wasting of lower legs, less severe impairment of distal thigh muscles, and sparing of proximal thigh muscles. A peculiar phenotype finding was that no or only slight muscle abnormalities could be found in the two female patients. We described the pattern of muscle involvement and disease progression in a family with CMT disease type 2 F. GRE dual-echo dual-flip angle MRI technique is a valuable technique to obtain a rapid quantification of MFF. (orig.)

  14. Ankle foot orthoses for people with Charcot Marie Tooth disease--views of users and orthotists on important aspects of use.

    Science.gov (United States)

    Phillips, Margaret; Radford, Kathryn; Wills, Adrian

    2011-01-01

    To explore important aspects of the benefits, important characteristics, barriers to use and disadvantages of using ankle foot orthoses (AFOs) as seen by people with Charcot Marie Tooth disease (CMT) and the orthotists who will fit and supply them. This qualitative study used the nominal group technique and individual semi-structured interviews, according to participant preference and ability to travel. Propositions were put to 15 participants (eight females) with CMT regarding benefits, disadvantages, barriers to use and important characteristics of ankle foot orthoses AFOs and regarding benefits and disadvantages to seven orthotists. Priorities in these areas were ranked and a thematic analysis of the free text was made separately by two observers and a joint decision made of final themes. Fifteen people (eight females) with CMT and seven orthotists participated. Users' themes concerned functional mobility walking, pain/discomfort, choice of AFOs and associated footwear, custom made design, use in practical situations and support for foot and ankle. They noted that AFOs improved walking, but practical aspects of use and provision, as well as consideration of cosmetic aspects, were frequently problematic. Orthotists had similar themes, but with a difference in emphasis, that included prevention of future complications, education regarding device limitations and craftsmanship as a further theme. Users understood the potential benefits of AFOs and could identify disadvantages which might be remedied, but were frustrated by the difficulties in translating this into practice. Further refinement of current orthoses and delivery of orthotic services may assist in addressing these issues. © 2011 Informa UK, Ltd.

  15. Loss of the E3 ubiquitin ligase LRSAM1 sensitizes peripheral axons to degeneration in a mouse model of Charcot-Marie-Tooth disease

    Directory of Open Access Journals (Sweden)

    Laurent P. Bogdanik

    2013-05-01

    Charcot-Marie-Tooth disease (CMT is a clinically and genetically heterogeneous condition characterized by peripheral axon degeneration with subsequent motor and sensory deficits. Several CMT gene products function in endosomal sorting and trafficking to the lysosome, suggesting that defects in this cellular pathway might present a common pathogenic mechanism for these conditions. LRSAM1 is an E3 ubiquitin ligase that is implicated in this process, and mutations in LRSAM1 have recently been shown to cause CMT. We have generated mouse mutations in Lrsam1 to create an animal model of this form of CMT (CMT2P. Mouse Lrsam1 is abundantly expressed in the motor and sensory neurons of the peripheral nervous system. Both homozygous and heterozygous mice have largely normal neuromuscular performance and only a very mild neuropathy phenotype with age. However, Lrsam1 mutant mice are more sensitive to challenge with acrylamide, a neurotoxic agent that causes axon degeneration, indicating that the axons in the mutant mice are indeed compromised. In transfected cells, LRSAM1 primarily localizes in a perinuclear compartment immediately beyond the Golgi and shows little colocalization with components of the endosome to lysosome trafficking pathway, suggesting that other cellular mechanisms also merit consideration.

  16. Loss of the E3 ubiquitin ligase LRSAM1 sensitizes peripheral axons to degeneration in a mouse model of Charcot-Marie-Tooth disease.

    Science.gov (United States)

    Bogdanik, Laurent P; Sleigh, James N; Tian, Cong; Samuels, Mark E; Bedard, Karen; Seburn, Kevin L; Burgess, Robert W

    2013-05-01

    Charcot-Marie-Tooth disease (CMT) is a clinically and genetically heterogeneous condition characterized by peripheral axon degeneration with subsequent motor and sensory deficits. Several CMT gene products function in endosomal sorting and trafficking to the lysosome, suggesting that defects in this cellular pathway might present a common pathogenic mechanism for these conditions. LRSAM1 is an E3 ubiquitin ligase that is implicated in this process, and mutations in LRSAM1 have recently been shown to cause CMT. We have generated mouse mutations in Lrsam1 to create an animal model of this form of CMT (CMT2P). Mouse Lrsam1 is abundantly expressed in the motor and sensory neurons of the peripheral nervous system. Both homozygous and heterozygous mice have largely normal neuromuscular performance and only a very mild neuropathy phenotype with age. However, Lrsam1 mutant mice are more sensitive to challenge with acrylamide, a neurotoxic agent that causes axon degeneration, indicating that the axons in the mutant mice are indeed compromised. In transfected cells, LRSAM1 primarily localizes in a perinuclear compartment immediately beyond the Golgi and shows little colocalization with components of the endosome to lysosome trafficking pathway, suggesting that other cellular mechanisms also merit consideration.

  17. Circulating microparticles in acute diabetic Charcot foot exhibit a high content of inflammatory cytokines, and support monocyte-to-osteoclast cell induction.

    Science.gov (United States)

    Pasquier, Jennifer; Thomas, Binitha; Hoarau-Véchot, Jessica; Odeh, Tala; Robay, Amal; Chidiac, Omar; Dargham, Soha R; Turjoman, Rebal; Halama, Anna; Fakhro, Khalid; Menzies, Robert; Jayyousi, Amin; Zirie, Mahmoud; Al Suwaidi, Jassim; Rafii, Arash; Malik, Rayaz A; Talal, Talal; Abi Khalil, Charbel

    2017-11-27

    Circulating microparticles (MPs) are major mediators in cardiovascular complications of type 2 diabetes (T2D); however, their contribution to Charcot foot (CF) disease is not known. Here, we purified and assessed the origin, concentration and content of circulating MPs from 33 individuals: 11 with T2D and acute CF, 11 T2D patients with equivalent neuropathy and 11 non-diabetic controls. First, we demonstrated that there were no differences in the distribution of MPs of endothelial, platelet origin among the 3 groups. However, MPs from leukocytes and monocytes origin were increased in CF patients. Moreover, we demonstrated that monocytes-derived MPs originated more frequently from intermediate and non-classical monocytes in CF patients. Five cytokines (G-CSF, GM-CSF, IL-1-ra, IL-2 and IL-16) were significantly increased in MPs from acute CF patients. Applying ingenuity pathways analysis, we found that those cytokines interacted well and induced the activation of pathways that are involved in osteoclast formation. Further, we treated THP-1 monocytes and monocytes sorted from healthy patients with CF-derived MPs during their differentiation into osteoclasts, which increased their differentiation into multinucleated osteoclast-like cells. Altogether, our study suggests that circulating MPs in CF disease have a high content of inflammatory cytokines and could increase osteoclast differentiation in vitro.

  18. A novel mutation in the nerve-specific 5'UTR of the GJB1 gene causes X-linked Charcot-Marie-Tooth disease.

    LENUS (Irish Health Repository)

    Murphy, Sinéad M

    2011-03-01

    X-linked Charcot-Marie-Tooth disease (CMT1X) is the second most common cause of CMT, and is usually caused by mutations in the gap junction protein beta 1 (GJB1) gene which codes for connexin 32 (CX32). CX32 has three tissue-specific promoters, P1 which is specific for liver and pancreas, P1a specific for liver, oocytes and embryonic stem cells, and P2 which is nerve-specific. Over 300 mutations have been described in GJB1, spread throughout the coding region. We describe two families with X-linked inheritance and a phenotype consistent with CMT1X who did not have mutations in the GJB1 coding region. The non-coding region of GJB1 was sequenced and an upstream exon-splicing variant found at approximately - 373G>A which segregated with the disease in both families and was not present in controls. This substitution is located at the last base of the nerve-specific 5\\'UTR and thus may disrupt splicing of the nerve-specific transcript. Online consensus splice-site programs predict a reduced score for the mutant sequence vs. the normal sequence. It is likely that other mutations within the GJB1 non-coding regions account for the CMT1X families who do not have coding region mutations.

  19. Dressing the Black Body. Mode, Hairstyle und Schwarzsein in den USA – von den 1970er-Jahren bis zu Barack Obama

    Directory of Open Access Journals (Sweden)

    Philipp Dorestal

    2017-08-01

    Full Text Available Conventional forms of African American activism and organization in the second half of the twentieth century have been the subject of academic research for quite some time, but less attention has been devoted to symbolic and body political forms of intervention. Looking at the Afro hairstyle and hip hop culture, this article explores how African American identity has been reflected through Style Politics. It outlines the history of African American hairstyles from the 1970s until the 2000s and identifies elements of popular culture such as Blaxploitation movies and rap music as constitutive of African American fashion. The question of ›respectability‹ that surfaced in the context of racist discourses about black women will be examined through the example of First Lady Michelle Obama, who rose to fame as a fashion icon. In conclusion, the article discusses the case of Trayvon Martin, an African American teenager who was killed in 2012 while wearing a hoodie, making the garment once again an object of contention and a symbol of protest. * * * Klassische Formen des Aktivismus und der Organisierung von African Americans in der zweiten Hälfte des 20. Jahrhunderts sind schon seit geraumer Zeit Gegenstand wissenschaftlicher Studien. In der bisherigen Forschung weniger gewürdigt wurden jedoch symbolische und körperpolitische Interventionsformen. Dieser Aufsatz geht anhand der Afro-Frisur und der durch die Hip-Hop-Kultur inspirierten Mode der Frage nach, wie afroamerikanische Identität über Style Politics verhandelt wurde. Skizziert wird die Geschichte afroamerikanischer Hairstyles von den 1970er- bis zu den 2000er-Jahren. Weiterhin werden Elemente der Populärkultur wie das Blaxploitation-Kino oder die seit den 1980er-Jahren verbreitete Rap-Musik als stilbildend für afroamerikanische Modephänomene identifiziert. Die Frage der »Respektabilität«, die im Kontext rassistischer Diskurse über schwarze Frauen auftauchte, wird anhand von Michelle

  20. Noise and vibration levels in artificial polar bear dens as related to selected petroleum exploration and developmental activities

    International Nuclear Information System (INIS)

    Blix, A.S.; Lentfer, J.W.

    1992-01-01

    Petroleum exploration and development are occurring in various locations in the Arctic, where there are important denning sites for polar bears. Petroleum activities usually coincide with winter denning activities by bears, who may abandon dens if subject to prolonged annoyance. A study was carried out to measure noise and vibration levels in artificial polar bear dens at Prudhoe's Bar, Alaska, resulting from seismic testing, drilling and transport. A microphone and an accelerometer were frozen to the floor of the dens, with leads passed through a consolidated snow filled entrance to a truck, tent or helicopter. Tests were carried out on land, sea ice, and next to a drilling tower on an artificial island, which was also used to measure noise levels resulting from a helicopter taking off. It was concluded that the dry and wind-beaten arctic snow muffles both sound and vibration extremely well, and it is unlikely that polar bears in their dens will be disturbed by the type of petroleum-related activities measured, provided they do not take place within 100 m of the dens. 8 refs., 7 figs., 1 tab

  1. Nuclear chemistry and Radiochemistry in the USA; Kern- und Radiochemie in den USA

    Energy Technology Data Exchange (ETDEWEB)

    Kronenberg, A. [Los Alamos National Lab., NM (United States). Isotope and Nuclear Chemistry Div.; Stoyer, M. [Lawrence Livermore National Lab., CA (United States)

    2004-04-01

    Nuclear chemistry and radiochemistry are very young sciences which developed at an extremely brisk pace within a very short period of time after the discovery of nuclear fission in 1938, and caused profound societal changes. In the United States, nuclear chemistry developed very differently from Germany, where nuclear research initially had been banned after the Second World War. The prime mover in the development in the United States was the Manhattan Project, the construction of the atomic bomb. The counteract the impending shortage of qualified personnel, important institutions have begun to establish training and support programs in the field. The National Laboratories in the United States introduced a National Security Internship Program, while the U.S. Department of Energy (DOE) tries to promote cooperation, and thus the training of personnel, by launching programs of its own. Yet, a greater shortage of qualified personnel is becoming apparent. The situation of nuclear chemistry and radiochemistry in the United States can be summarized in the finding that research at the National Laboratories is very wide ranging. It receives sufficient funds from the DOE. However, the National Laboratories show a very high proportion of elderly personnel, a problem which will have to be corrected in the years to come. This may be helped by the Summer Schools financed by the DOE, though a summer school of six weeks cannot replace a sound training in nuclear chemistry of the kind still to be found in Germany. (orig.) [German] Kern- und Radiochemie sind sehr junge Wissenschaften, die sich nach der Entdeckung der Kernspaltung 1938 innerhalb kuerzester Zeit extrem rasant entwickelt und tiefe gesellschaftliche Veraenderungen bewirkt haben. In den USA hat sich die Kernchemie sehr unterschiedlich im Vergleich zu Deutschland entwickelt, wo die Kernforschung nach dem 2. Weltkrieg vorerst verboten war. Massgeblich in den USA war dabei das Manhatten-Projekt zum Bau von Nuklearwaffen

  2. The Possible HEPATOPROTECTIVE Effect Of Taurine In Diethyl Nitrosamine (DEN) Treated Rats

    International Nuclear Information System (INIS)

    SHAROUD, M.N.M.; ABD EL-MONEIM, A.E.

    2009-01-01

    Egypt occupies a progressed rank among the developing countries in prevalence of hepatic diseases and liver disorders. Hepatopathies are major public health problems in Egypt where hepatitis C virus (HCV) and schistosomia record a high prevalence which may account for the most serious clinical disorders e.g. liver cirrhosis and liver cancer.Vascular endothelial growth factor (VEGF) is the most specific and potent mitogen of endothelial cells. Hepatocellular carcinoma (HCC) is characterized by increased pathologic angio genesis and increased level of the vascular endothelial growth factor. Taurine is clinically used as a protecting agent of the liver and recently, its chemo preventive effect on rat large bowel carcinogenesis was reported.In this study, forty male albino rats were used and diethyl nitrosamine (DEN) was used for inducing pathological changes in different organs while taurine was given to investigate the possible protective effects on liver tissue after DEN treatment.The results showed elevation in serum AST, ALT, ALP, urea, creatinine, cholesterol and triglycerides in DEN group. On the other hand, estimation of sex hormones exhibited marked decrease in testosterone and significant increase in estradiol levels in DEN group as compared to control and taurine groups.Pathological examination of rat liver showed that DEN induced peri portal inflammatory cellular infiltrate, piece meal necrosis and necro inflammatory activity as well as the appearance of areas of haemorrhage and ballooning in hepatocytes. Moreover, moderate to high expression of V EGF in the cytoplasm of hepatocytes and sinusoidal cells were clearly observed while in control and taurine groups, normal architecture of hepatic tissue of rats was found and normal distribution of V EGF as diffuse or focal granular cytoplasmic stain in rats liver were observed. The prophylactic group showed minimal and mild changes in the liver tissue with absence of necro inflammation and the V EGF expression

  3. HyDEn: A Hybrid Steganocryptographic Approach for Data Encryption Using Randomized Error-Correcting DNA Codes

    Directory of Open Access Journals (Sweden)

    Dan Tulpan

    2013-01-01

    Full Text Available This paper presents a novel hybrid DNA encryption (HyDEn approach that uses randomized assignments of unique error-correcting DNA Hamming code words for single characters in the extended ASCII set. HyDEn relies on custom-built quaternary codes and a private key used in the randomized assignment of code words and the cyclic permutations applied on the encoded message. Along with its ability to detect and correct errors, HyDEn equals or outperforms existing cryptographic methods and represents a promising in silico DNA steganographic approach.

  4. Kampen om den røde ko - dominerende temaer i dansk kvægavl i 1800-tallets slutning

    DEFF Research Database (Denmark)

    Gjerløff, Anne Katrine

    2009-01-01

    En analyse af kvægavlslitteratur fra 1800-tallets anden halvdel viser spændingerne mellem avlernes ønske om profit og hensynene til racerenhed og national og regional identitet. Ideen om den perfekte ko var omdiskuteret og modsætningerne mellem koens udseende og dens ydelse er tydelige i periodens...... bedømmelser af "den gode ko". Artiklen komkluserer at et fokus på opfattelser og brug af dyr kan give nye vinkler på traditionelle historiske emnefelter. Udgivelsesdato: april...

  5. ”Hvis du redder et menneske, så har du reddet hele verden”. Den gode moralen og den dialogiske samtalen i et norsk klasserom

    Directory of Open Access Journals (Sweden)

    Sylvi Penne

    2009-03-01

    Full Text Available Artikkelen tar utgangspunkt i observasjoner fra et klasserom på ungdomstrinnet der elevene arbeider tverrfaglig i norsk, KRL og samfunnsfag. Temaet er blant annet jødenes situasjon før og under krigen. Læreren er faglig dyktig, erfaren og sterkt engasjert i å formidle overgrepene som ble begått mot jødene, og elevene er velvillige. Likevel er elevenes konklusjon at de i en krigssituasjon med en etisk fordring, ikke ville ha våget å gjøre noe for å hjelpe jødene.      Med utgangspunkt i diskursteori, sosiokulturell teori og nyere kognitiv teori diskuteres disse svarene som ”naturlige” svar i den konteksten som skapes i klasserommet, og gjennom det språket som elevene utfordres i, deres ”mediational means”. Et konkret didaktisk problem er at den historiske fortellingen er borte og erstattet av empatisk innlevelse. Artikkelen avslutter med å hevde at uten en narrativ ramme forsvinner muligheten for etisk erkjennelse gjennom konteksten som skapes, og gjennom materialet som foreligger. Her ligger imidlertid nye didaktiske muligheter for engasjerte lærere, ikke minst gjennom litteraturundervisning.

  6. CheckDen, a program to compute quantum molecular properties on spatial grids.

    Science.gov (United States)

    Pacios, Luis F; Fernandez, Alberto

    2009-09-01

    CheckDen, a program to compute quantum molecular properties on a variety of spatial grids is presented. The program reads as unique input wavefunction files written by standard quantum packages and calculates the electron density rho(r), promolecule and density difference function, gradient of rho(r), Laplacian of rho(r), information entropy, electrostatic potential, kinetic energy densities G(r) and K(r), electron localization function (ELF), and localized orbital locator (LOL) function. These properties can be calculated on a wide range of one-, two-, and three-dimensional grids that can be processed by widely used graphics programs to render high-resolution images. CheckDen offers also other options as extracting separate atom contributions to the property computed, converting grid output data into CUBE and OpenDX volumetric data formats, and perform arithmetic combinations with grid files in all the recognized formats.

  7. Franchising i den svenska fastighetsmäklarbranschen : Franchising in the Swedish real estate industry

    OpenAIRE

    Narkander, Christoffer; Ilchishina, Elena

    2010-01-01

    Sammanfattning Bakgrund Idag blir det allt mer vanligt att mindre enskilda mäklarbyråer ansluter sig till de stora franchisekedjorna. Anslutningen innebär att den tidigare enskilde aktören lämnar sitt varumärke och sin tidigare affärsidé för att istället ta del av ett välkänt varumärke och ett framgångsrikt affärskoncept. Syfte & metod Syftet med uppsatsen är att studera vilka positiva och negativa effekter franchising bidrar med i den svenska fastighetsmäklarbranschen samt vilka ekonom...

  8. Rückwärtsintegration - Zu den Verhältnissen Gymnasium, Hochschule und Arbeitswelt

    Science.gov (United States)

    Schmid, Gerhard; Heppner, Winfried; Focht, Eva

    In seiner 2007 erschienen Sammlung von Vorträgen und Essays beschäftigt sich Wolfgang Frühwald, mit der Frage "Wieviel Wissen brauchen wir?“ [1] Die Kernproblematik moderner Wissenschaft und Forschung sieht der Autor, emeritierter Ordinarius für Neuere Deutsche Literaturwissenschaft und von 1992 bis 1997 Präsident der Deutschen Forschungsgemeinschaft, einerseits in der zunehmenden Spezialisierung der Wissenschaftsbereiche, andererseits in der Gefahr der Abkoppelung der Naturwissenschaften von den Geisteswissenschaften. Wiederholt plädiert er dafür, über der rasanten Entwicklung beispielsweise in der Biologie und Physik, die historische, gesellschaftliche und besonders die ethische Dimension der Forschung nicht zu übersehen und fordert eine übergeordnete Theorie der Wissenschaft, die nur im Dialog zwischen den einzelnen Fachgebieten zu entwickeln sei.

  9. Den danske samfundsudvikling 1848-2012 og marxistisk, neoklassisk, keynesiansk, monetaristisk og nykeynesiansk teori

    DEFF Research Database (Denmark)

    Madsen, Poul Thøis

    Efter i adskillige år at have undervist ud fra andres bøger og efter mange tilløb besluttede forfatteren sig for at skrive sin egen forskningsbaserede bog til Det Samfundsvidenskabelige Fællessemester, som dækker fem lektioner om den politiske økonomis historie og den danske økonomiske udvikling........ Ambitionen har været at udarbejde en kort appetitvækker, der gør, at studerende får et overblik og forstår nogle basale sammenhænge og får lyst til at vide mere om økonomisk teori, dansk og international økonomi og ikke mindst debatterne herom....

  10. Management of type II dens invaginatus and peg laterals with spacing of maxillary anteriors

    Directory of Open Access Journals (Sweden)

    Tina Puthen Purayil

    2015-01-01

    Full Text Available A case of peg-shaped lateral with dens invaginatus (DI and midline diastema affecting maxillary incisors in a 32-year old female patient is discussed. This clinical report describes the endodontic management of DI in tooth #12, esthetic correction of peg laterals and diastema with all ceramic restorations. Satisfactory results were achieved esthetically following treatment and gave the patient a new confident smile.

  11. DIE ERFORSCHUNG DER VEGETATIONSDYNAMIK IN DEN NORDWESTEN DES BANATS (KREIS TEMESCH, RUMÄNIEN

    Directory of Open Access Journals (Sweden)

    M. Fizitea

    2004-01-01

    Full Text Available Die Evolution und Aufeinanderfolge der Vegetationsvereine erfolgte in enger Verbindung mit den pädoklimatischen und zooantropischen Faktoren. Die Periode der antropogenen Vegetation wird charakterisiert durch die Vorherrschaft der gezüchteten Arten, welche zur Verbreitung der Agrophytozönosen sowie der ruderolen und segetalen Vegetation führte und somit die vorherigen Phytozönosen ersetzt.

  12. Single-session treatment of a major complication of dens invaginatus: a case report.

    Science.gov (United States)

    Caldari, Mauro; Monaco, Carlo; Ciocca, Leonardo; Scotti, Roberto

    2006-05-01

    Dens invaginatus is a dental malformation that may give rise to several complications. Caries of the invagination can severely weaken the whole tooth, making it susceptible to fracture. Subgingival fractures are major complications threatening tooth survival and usually require periodontal/orthodontic/prosthetic treatment if long-term viability is to be ensured. This article describes a case of single-session restoration of a fractured invaginated tooth by means of endodontic treatment followed by fragment reattachment.

  13. Når almenpædagogikken bliver den bedste forbyggelse af angst

    DEFF Research Database (Denmark)

    Hviid, Pernille; Esbjørn, Barbara Hoff; Villadsen, Jakob Waag

    2018-01-01

    Formålet med artiklen er at invitere til dialog mellem børneklinisk, almen udviklingspsykologisk og almen pædagogisk praksis med henblik på forebyggelse af angst hos børn. Artiklen forsøger at begrebsliggøre og videreudvikle kvaliteter ved den almene pædagogiske praksis i relation til børneklinis...

  14. A Rare Case of Parkinson's Disease with Severe Neck Pain Owing to Crowned Dens Syndrome

    OpenAIRE

    Teruyuki Takahashi; Masato Tamura; Keiichi Osabe; Takashi Tamiya; Kenji Miki; Mai Yamaguchi; Kanno Akira; Satoshi Kamei; Toshiaki Takasu

    2014-01-01

    Background: Pain is regarded as one of the most common nonmotor symptoms in Parkinson's disease (PD). In particular, musculoskeletal pain has been reported as the most common type of PD-associated pain. Crowned dens syndrome (CDS), related to microcrystalline deposition in the periodontoid process, is the main cause of acute or chronic cervical pain. Case Presentation: This report describes the case of an 87-year-old woman who had severe bradykinesia, muscle rigidity, gait disturbance and nec...

  15. Refrigeration compressor for the mobile application; Kaeltemittelverdichter fuer den mobilen Einsatz

    Energy Technology Data Exchange (ETDEWEB)

    Hagenlocher, T. [Bock GmbH und Co. Kaeltemaschinenfabrik, Frickenhausen (Germany)

    2000-06-01

    The mobile use of cooling air conditioning systems is increasingly important. Main component of this system is the refrigeration compressor. The special requirement for the compressor as well for the resulting boundary conditions are discussed. (orig.) [German] Der mobile Einsatz von Kaelte- und Klimaanlagen gewinnt zunehmend an Bedeutung. Wichtigste Komponente dieser Anlage ist der Kaeltemittelverdichter. Die speziellen Anforderungen an den Verdichter sowie an die daraus resultierenden Randbedingungen werden dargestellt. (orig.)

  16. SensInDenT-Noncontact Sensors Integrated Into Dental Treatment Units.

    Science.gov (United States)

    Teichmann, Daniel; Teichmann, Maren; Weitz, Philippe; Wolfart, Stefan; Leonhardt, Steffen; Walter, Marian

    2017-02-01

    This paper presents the first system design (SensInDenT) for noncontact cardiorespiratory monitoring during dental treatment. The system is integrated into a dental treatment unit, and combines sensors based on electromagnetic, optical, and mechanical coupling at different sensor locations. The measurement principles and circuits are described and a system overview is presented. Furthermore, a first proof of concept is provided by taking measurements in healthy volunteers under laboratory conditions.

  17. Die Entstehung des „Judenbildes“ in den Alltagsmedien des 19. Jahrhunderts

    Directory of Open Access Journals (Sweden)

    Ute Wrocklage

    2001-07-01

    Full Text Available In der zweiten Hälfte des 19. Jahrhunderts beginnen, Illustratoren und Zeichner von Bildwitzen und Karikaturen das stereotype und in der Folge antisemitische Bild vom Juden herauszubilden. Es findet schnell Eingang in die illustrierten Zeitschriften und Bilderbögen der Zeit. In diesen drei untersuchten Bildmedien kennzeichnen neben der Physiognomie diskriminierende Attribute den Juden als Typus. Dieser Entwicklung und der Herausbildung der Stereotype zum antisemitischen Judenbild geht die Arbeit nach.

  18. Frieden durch Ineffizienz? Die Reform der US Cyberwar Strategie nach den Snowden-Leaks

    OpenAIRE

    Schmetz, Martin

    2013-01-01

    Es tut sich etwas in Folge der Snowden-Leaks: In den USA werden Untersuchungsausschüsse eingesetzt, Vorstöße, die Macht der NSA einzuschränken bzw.transparenter zu gestalten werden stärker – vor allem aber wird es wohl institutionelle Änderungen geben. Und diese hängen an einer Person: Keith Alexander.

  19. At Forberede sig til den mundtlige prøve ( kap12)

    DEFF Research Database (Denmark)

    Nørgaard, Britta Kusk

    2015-01-01

    Et opslagsværk for studerende til støtte for bacheloropgaveskrivning. Klæd dine studerende på til at skrive den store afsluttende opgave. De studerende får med denne bog et gedigent opslagsværk, som giver svar på alle de spørgsmål, det typisk trænger sig på, når bacheloropgaven skal påbegyndes. B...

  20. Et slag for den stolte håndværker

    DEFF Research Database (Denmark)

    Henriksen, Carsten

    2013-01-01

    Snart vil samfundet skrige af mangel på dygtige håndværkere, lyder det fra politikere og erhvervsfolk. Asterisk har sat den ansete amerikanske sociolog Richard Sennett i stævne for at få svar på, hvad vi kan lære af godt håndværk, og hvorfor det har trange kår i et konkurrencestyret vidensamfund....

  1. Die Bedeutung internationaler Erfahrungen für den Karriereerfolg von Führungskräften

    OpenAIRE

    Biemann, Torsten

    2009-01-01

    Die langfristigen Auswirkungen internationaler Einsätze von Führungskräften auf deren Karrieren sind bislang kaum empirisch untersucht worden und die wenigen vorliegenden Ergebnisse sind widersprüchlich. Ziel dieser Studie ist deshalb die empirische Untersuchung der Auswirkungen internationaler Erfahrungen auf den Karriereerfolg von Führungskräften anhand eines Vergleichs von Führungskräften mit und ohne internationale Erfahrungen. Es zeigt sich, dass internationale Erfahrungen zu einem höher...

  2. Die Analyse der Wertschöpfungskette Schweinefleisch unter den Aspekten des Supply Chain Management

    OpenAIRE

    Schönberger, Wolfgang

    2008-01-01

    Inhalt der Arbeit ist die vergleichende Analyse der Wertschöpfungskette Schweinefleisch unter den Aspekten des Supply Chain Management für Bayern sowie für Dänemark als dem weltweit größten Nettoexporteur von Schweinefleisch. Wichtige Wettbewerbsfaktoren und die Strukturen der Wertschöpfungskette werden untersucht. Die Produktionskosten werden nach der Methode der Vollkostenrechnung ermittelt. In Dänemark haben sich auf allen Stufen der Wertschöpfungskette Strukturen entwickelt, die die...

  3. Einflussfaktoren auf den persönlichen Stress bei Studienanfängern in der Humanmedizin

    OpenAIRE

    Schulze, Johannes; Duderstadt, Monika; Hodjat, Beheshta; Wu, Yue-Ying

    2013-01-01

    Die derzeitige Regelung der Zulassung zum Medizinstudium berücksichtigt die Abiturnote und Wartezeiten; universitäre Parameter können diese Kriterien modifizieren. Hierzu zählen z.B. die Leistungskurswahl, wie es an der Goethe-Universität Frankfurt gehandhabt wird. Im Rahmen der Untersuchung zu Stress und Resilienz bei Medizinstudenten haben wir bei den Studenten des 1. vorklinischen Semesters soziodemographische Daten erhoben, die einen Kohortenvergleich erlauben. Die chronische Stressbelast...

  4. Quantitative fluorescence-polymerase chain reaction assay for the detection of the duplication of the Charcot Marie Tooth disease type 1A critical region.

    Science.gov (United States)

    De Toffol, Simona; Bellone, Emilia; Dulcetti, Francesca; Ruggeri, Anna Maria; Maggio, Pietro Paolo; Pulimeno, Maria Rosaria; Mandich, Paola; Maggi, Federico; Simoni, Giuseppe; Grati, Francesca Romana

    2010-04-01

    Charcot Marie Tooth (CMT) syndrome is the most common hereditary peripheral neuropathy, with an incidence of about 1 in 2500. The subtype 1A (CMT1A) is caused by a tandem duplication of a 1.5-Mb region encompassing the PMP22 gene. Conventional short tandem repeat (STR) analysis can reveal this imbalance if a triallelic pattern, defining with certainty the presence of duplication, is present. In case of duplication with a biallelic pattern, it can only indicate a semiquantitative dosage of the fluorescence intensity ratio of the two fragments. In this study we developed a quantitative fluorescence-PCR using seven highly informative STRs within the CMT1A critical region that successfully disclosed or excluded the presence of the pathogenic imbalance in a cohort of 60 samples including 40 DNAs from samples with the CMT1A duplication previously characterized with two different molecular approaches, and 20 diagnostic samples from 10 members of a five-generation pedigree segregating CMT1A, 8 unrelated cases and 2 prenatal samples. The application of the quantitative fluorescence-PCR using STRs located in the critical region could be a reliable method to evaluate the presence of the PMP22 duplication for the diagnosis and classification of hereditary neuropathies in asymptomatic subjects with a family history of inherited neuropathy, in prenatal samples in cases with one affected parent, and in unrelated patients with a sporadic demyelinating neuropathy with clinical features resembling CMT (i.e., pes cavus with hammer toes) or with conduction velocities in the range of CMT1A.

  5. A comparative study of zoledronic acid and once weekly Alendronate in the management of acute Charcot arthropathy of foot in patients with diabetes mellitus

    Directory of Open Access Journals (Sweden)

    R Bharath

    2013-01-01

    Full Text Available Aim: The aim of this study was to assess and compare the response to two forms of treatment-immobilization with zoledronic acid injection and immobilization with oral weekly Alendronate, in patients with diabetes mellitus and acute Charcot arthropathy (CA of foot in terms of clinical and radiological parameters. Material and Methods: Patients attending the endocrinology and podiatry clinic with history of diabetes mellitus and Acute CA were taken for study. The patients were randomized into two treatment groups. Group Z-zoledronic acid injection along with total contact cast (TCC. Group A-Tab. Alendronate 70 mg. once a week till the complete clinical resolution of acute CA along with TCC. Forty-five patients were randomized and 40 of them completed the study. The primary end point was complete clinical resolution of acute CA-defined as temperature difference between normal and affected foot <1oF. Results: Among the 40 patients, 30 (75% had complete clinical resolution. The mean number of days taken for complete clinical resolution since the initiation of treatment (either Zoledronic acid or Alendronate was approximately 122 days. There was no significant difference in a number of days required for complete clinical resolution, between the two forms of therapy. There was more than 50% reduction in the visual score between the baseline and the final scan. The target to non-target ratio in the skeletal phase also showed an average of 40% reduction from the baseline to the final skeletal scintigraphy. Conclusion: Both Intravenous Zoledronic acid and oral alendronate had comparable efficacy with respect to the time taken for attaining complete clinical resolution of acute CA of foot. However, Alendronate therapy was cost effective among the two. 99m Tc MDP bone scan can be used as an adjuvant to the clinical parameters in assessing the response to therapy.

  6. Gait and footwear in children and adolescents with Charcot-Marie-Tooth disease: A cross-sectional, case-controlled study.

    Science.gov (United States)

    Kennedy, Rachel A; McGinley, Jennifer L; Paterson, Kade L; Ryan, Monique M; Carroll, Kate

    2018-05-01

    Children with Charcot-Marie-Tooth disease (CMT) report problems with gait and footwear. We evaluated differences in spatio-temporal gait variables and gait variability between children with CMT and typically developing (TD) children, and investigated the effect of footwear upon gait. A cross-sectional study of 30 children with CMT and 30 age- and gender-matched TD children aged 4-18 years. Gait was assessed at self-selected speed on an electronic walkway while barefoot and in two types of the child's own footwear; optimal (e.g., athletic-type runners) and suboptimal (e.g., flip-flops). Children with CMT walked more slowly (mean (SD) -13.81 (3.61) cm/s), with shorter steps (-6.28 (1.37) cm), wider base of support (+2.47 (0.66) cm; all p footwear than suboptimal (-7.55 (1.31) cm/s) and barefoot (-7.42 (1.07) cm/sec; both p footwear was more variable compared to barefoot and optimal footwear. Greater base of support variability and reduced balance was moderately correlated for both groups (CMT and TD). Gait is slower with shorter, wider steps and greater base of support variability in children with CMT. Poor balance is associated with greater base of support gait variability. Suboptimal footwear negatively affects gait in all children (CMT and TD), which has clinical implications for children and adolescents with CMT who have weaker feet and ankles, and poor balance. Copyright © 2018 Elsevier B.V. All rights reserved.

  7. Novel INF2 mutations in an Italian cohort of patients with focal segmental glomerulosclerosis, renal failure and Charcot-Marie-Tooth neuropathy.

    Science.gov (United States)

    Caridi, Gianluca; Lugani, Francesca; Dagnino, Monica; Gigante, Maddalena; Iolascon, Achille; Falco, Mariateresa; Graziano, Claudio; Benetti, Elisa; Dugo, Mauro; Del Prete, Dorella; Granata, Antonio; Borracelli, Donella; Moggia, Elisabetta; Quaglia, Marco; Rinaldi, Rita; Gesualdo, Loreto; Ghiggeri, Gian Marco

    2014-09-01

    Mutations of INF2 represent the major cause of familial autosomal dominant (AD) focal segmental glomerulosclerosis (FSGS). A few patients present neurological symptoms of Charcot-Marie-Tooth (CMT) disease but the prevalence of the association has not been assessed yet. We screened 28 families with AD FSGS and identified 8 INF2 mutations in 9 families (32 patients overall), 3 of which were new. Mutations were in all cases localized in the diaphanous-inhibitory domain (DID) of the protein. Clinical features associated with INF2 mutations in our patient cohort included mild proteinuria (1.55 g/L; range 1-2.5) and haematuria as a unique symptom that was recognized at a median age of 21.75 years (range 8-30). Eighteen patients developed end-stage renal disease during their third decade of life; 12 patients presented a creatinine range between 1.2 and 1.5 mg/dL and 2 were healthy at 45 and 54 years of age. CMT was diagnosed in four cases (12.5%); one of these patients presented an already known mutation on exon 2 of INF2, whereas the other patients presented the same mutation on exon 4, a region that was not previously associated with CMT. We confirmed the high incidence of INF2 mutations in families with AD FSGS. The clinical phenotype was mild at the onset of the disease, but evolution to ESRD was frequent. The incidence of CMT has, for the first time, been calculated here to be 12.5% of mutation carriers. Our findings support INF2 gene analysis in families in which renal failure and/or neuro-sensorial defects are inherited following an AD model. © The Author 2014. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.

  8. Gait analysis in a patient with severe Charcot-Marie-Tooth disease: a case study with a new orthotic device for footdrop.

    Science.gov (United States)

    Vinci, Paolo; Paoloni, M; Ioppolo, F; Gargiulo, P; Santilli, V

    2010-09-01

    Management of footdrop in severe Charcot-Marie-Tooth (CMT) patients is a challenge owing to the combination of quadriceps muscle weakness, distal muscular atrophy, sensory impairment and poor soft tissue resistance to the placement of an orthotic device. We present a case study of a patient who gradually became unable to use his ankle-foot orthoses because they hampered the compensative movements required to stabilize his knees passively and caused pain. The aim of this report is to describe orthotic management in such a severe CMT case and to present a new orthotic device that we devised for the footdrop in this patient. We provided him with 3 different footdrop devices, each of which was highly elastic to allow knee hyperextension, and left him free to decide which one to use: 1) the silicone-ankle-foot orthoses were rapidly discarded because of pain; 2) the Codivilla support was not used because of discomfort and poor aesthetic appearance; 3) a new device, called the "Soft Footdrop Insert" (SFI), consisting of a sheet of Veolform, a reticulated polyolephinic foam, stuck to the counter of midcalf boots, was found to be effective, comfortable, pain-free and aesthetically acceptable, and was consequently used the vast majority of the time. At a 3-year follow-up, an instrumental gait analysis, in which ordinary shoes were compared with the Codivilla support and the SFI, revealed that both the Codivilla support and the SFI controlled footdrop more effectively than ordinary shoes and increased swing and mean velocity; in addition, the SFI yielded the best gait performances. We think that a soft, invisible device, such as the SFI, may satisfy the needs of CMT patients and improve compliance with orthoses-wearing for footdrop.

  9. Prevalence of Charcot Arthropathy in Type 2 Diabetes Patients Aged over 50 Years with Severe Peripheral Neuropathy: A Retrospective Study in a Tertiary Care South Indian Hospital.

    Science.gov (United States)

    Salini, Dharmadas; Harish, Kumar; Minnie, Pillay; Sundaram, Karimassery R; Arun, Bal; Sandya, Chirukandath J; Mangalanandan, Thacho S; Vivek, Lakshmanan; Praveen, Valiyaparambil P

    2018-01-01

    Available literature on the prevalence of Charcot arthropathy (CA) represents mainly Western population. No study has been reported from India so far. Hence we attempted to study the prevalence of CA in patients with type 2 diabetes mellitus and severe peripheral neuropathy (T2DMPN), belonging to Indian population amongst whom type 2 diabetes is on the rise in alarming proportions. Medical records of 3387 patients who performed an objective vibration perception threshold test during the year 2015 were screened for T2DMPN. Out of these, 1475 T2DMPN patients above 50 years were selected and analyzed in detail for CA. CA was diagnosed based on clinical features and/or radiological investigations. The anatomical localization of the disease distribution of the affected foot was done according to Brodsky's classification. The prevalence of CA in T2DMPN patients was found to be 9.8%. The mean age of patients diagnosed with CA was 63 ± 8.36 years, and mean duration of DM for CA to develop was 18.01 ± 8.23 years. About 62.5% of the patients were male and 37.5% female. Bilateral presentation of CA was observed in 20.8% of patients. Multiple sites of the foot were affected in 48.6% of patients and belonged to type 4 classification of Brodsky. A high prevalence of CA (9.8%) was observed in the present study conducted on T2DMPN patients who presented to the endocrinology department of a tertiary care South Indian hospital. In the majority of patients, the area of foot affected belonged to type 4 classification of Brodsky.

  10. Frecuencia del alelo causante de la enfermedad de Charcot-Marie-Tooth (tipo axonal con herencia autosómica recesiva en Palmares, Costa Rica

    Directory of Open Access Journals (Sweden)

    Melissa Rojas-Araya

    2009-11-01

    Full Text Available La enfermedad de Charcot-Marie-Tooth constituye elgrupo de neuropatías periféricas hereditarias más común a nivel mundial. Una familia con 18 afectados del cantón de Palmares (Alajuela, Costa Rica con una neuropatía de tipo axonal y herencia autosómica recesiva, permitió localizar el gen responsable en la región 19q13.33. Posteriormente se identificó la mutación causante en el gen MED25. El presente estudio determinó la frecuencia del alelo mutante, así como la distribución geográfica de este alelo. En una muestra al azar de 103 individuos se encontraron seis individuos heteroigotas para la mutación, distribuidos por todo el cantón. No se encontró ninguna persona en estado homocigota para este alelo. No hallamos algunacaracterística clínica que difiera significativamente entre los individuos homocigotos silvestres y los heterocigotos para la mutación. El 5.83% de la población es heterocigota y la frecuencia del alelo Ala335Val es de 0.029, seis veces mayor que en una muestra de toda la población costarricense. Por esta razón se recomienda un análisis molecular de portadores con el fin de alertar sobre la posibilidad de aparición de más casos en el cantón.

  11. Melatonin Treatment Reduces Oxidative Damage and Normalizes Plasma Pro-Inflammatory Cytokines in Patients Suffering from Charcot-Marie-Tooth Neuropathy: A Pilot Study in Three Children.

    Science.gov (United States)

    Chahbouni, Mariam; López, María Del Señor; Molina-Carballo, Antonio; de Haro, Tomás; Muñoz-Hoyos, Antonio; Fernández-Ortiz, Marisol; Guerra-Librero, Ana; Acuña-Castroviejo, Darío

    2017-10-14

    Charcot-Marie-Tooth neuropathy (CMT) is a motor and sensory neuropathy comprising a heterogeneous group of inherited diseases. The CMT1A phenotype is predominant in the 70% of CMT patients, with nerve conduction velocity reduction and hypertrophic demyelination. These patients have elevated oxidative stress and chronic inflammation. Currently, there is no effective cure for CMT; herein, we investigated whether melatonin treatment may reduce the inflammatory and oxidative damage in CMT1A patients. Three patients, aged 8-10 years, were treated with melatonin (60 mg at 21:00 h plus 10 mg at 09:00 h), and plasma levels of lipid peroxidation (LPO), nitrites (NOx), IL-1β, IL-2, IL-6, TNF-α, INF-γ, oxidized to reduced glutathione (GSSG/GSH) ratio, and the activities of superoxide dismutase (SOD), glutathione-S transferase (GST), glutathione peroxidase (GPx), and reductase (GRd), were determined in erythrocytes at 3 and 6 months of treatment. Healthy age- and sex-matched subjects were used as controls. The results showed increased activities of SOD, GST, GPx, and GRd in CMT1A patients, which were reduced at 3 and 6 months of treatment. The GSSG/GSH ratio significantly increased in the patients, returning to control values after melatonin treatment. The inflammatory process was confirmed by the elevation of all proinflammatory cytokines measured, which were also normalized by melatonin. LPO and NOx, which also were elevated in the patients, were normalized by melatonin. The results document beneficial effects of the use of melatonin in CMT1A patients to reduce the hyperoxidative and inflammatory condition, which may correlate with a reduction of the degenerative process.

  12. Scintigraphic examinations after stent implantation in central airways; Szintigraphische Untersuchungen bei Stents in den zentralen Atemwegen

    Energy Technology Data Exchange (ETDEWEB)

    Richter, W.S.; Kettner, B.I.; Munz, D.L. [Klinik und Poliklinik fuer Nuklearmedizin, Universitaetsklinikum Charite, Medizinische Fakulteat der Humboldt-Univ. zu Berlin (Germany)

    1998-03-01

    Endotracheal and endobronchial stent implantation has been developed as an effective treatment of benign and malignant airway stenosis and of tracheo- or bronchoesophageal fistulas. The selection of the stent type depends on the kind and site of disease. Chest X-ray and bronchoscopy are the procedures of choice for monitoring of stent position, structure, and function. However, with scintigraphic methods the effects of stent implantation on pulmonary ventilation and perfusion can be assessed non-invasively. The validation of the effect of a stent implantation on mucociliary and tussive clearance remains to be elucidated. (orig.) [Deutsch] Die endotracheale und -bronchiale Stentimplantation wurde in den letzten Jahren als effektive Massnahme bei benignen und malignen Stenosen der Atemwege, drohendem Atemwegsverschluss und bei tracheo- bzw. bronchooesophagealen Fisteln eingefuehrt. Der gewaehlte Stenttyp richtet sich nach dem Implantationsort und den krankheitsbedingten Veraenderungen. Zum Monitoring von Lage, Struktur und Funktion eines Stents dienen Thoraxroentgenaufnahmen und die Bronchoskopie. Nuklearmedizinische Verfahren koennen nicht-invasiv den Effekt der Stenteinlage auf Lungenventilation und -perfusion belegen. Die Validierung des Effekts einer Stentimplantation auf die mukoziliaere und tussive Clearance steht noch aus. (orig.)

  13. The utopian challenge to global capitalism by Walter van den Broeck in Terug naar Walden

    Directory of Open Access Journals (Sweden)

    Andries Visagie

    2012-12-01

    Full Text Available The socialist sympathies that inform the writing of Flemish author Walter van den Broeck align him with a well-established tradition of socially engaged writing in Flanders. In his novel Terug naar Walden (Back to Walden, published in 2009, he revisits the Walden project of the Dutch reformer and writer Frederik van Eeden (1860−1932. Van den Broeck suggests that a reconsideration of the socialist ideals that inspired Van Eeden to establish settlements in the Netherlands and the United States is warranted in the light of the economic crisis triggered by unchecked capitalist practices in 2008. In Terug naar Walden Ruler Marsh, the richest man in the world, unleashes a global financial crisis as a form of retaliation against the capitalist system that ruined his parents. Marsh returns to the Kempen in Flanders where his family originated. In a Heideggerean affirmation of the local as exemplified by the country road, Van den Broeck articulates his vision of the common, that theorists Michael Hardt and Antonio Negri in their Empire trilogy have attempted to salvage from communist thinking, with a utopian notion that a stronger connection with the land and the people within one’s immediate environment may provide a useful premise for the development of viable alternatives to capitalism.

  14. Untersuchung perturbativer und nichtperturbativer Struktur der Momente hadronischer Ereignisformvariablen mit den Experimenten JADE und OPAL

    CERN Document Server

    Pahl, Christoph Johannes

    2007-01-01

    In Hadronproduktionsdaten der e+e− - Vernichtungsexperimente JADE und OPAL messen wir die ersten f¨unf Momente von zw¨olf hadronischen Ereignisformvariablen bei Schwerpunktsenergien von 14 bis 207GeV. Aus dem Vergleich der QCD NLO-Vorhersage mit den mittels MC-Modellen um Hadronisierung korrigierten Daten erhalten wir den Referenzwert der starken Kopplung αs(MZ0) = 0.1254 ± 0.0007(stat.) ± 0.0010(exp.)+0.0009 −0.0023(had.)+0.0069 −0.0053(theo.) . F¨ur einige, insbesondere h¨ohere, Momente sind systematische Unzul¨anglichkeiten in der QCD NLO-Vorhersage erkenntlich. Simultane Fits an zwei Momente unter Annahme identischer Renormierungsskalen ergeben Skalenwerte von xμ=0.057 bis xμ=0.196 . Wir pr¨ufen Vorhersagen verschiedener nichtperturbativer Modelle. Aus der Single Dressed Gluon - N¨aherung ergibt sich eine perturbative Vorhersage in O(α5 s ) mit zu vernachl¨assigender Energiepotenzkorrektur, die den Mittelwert von Thrust auf Hadronniveau gut beschreibt mit αs(MZ0) = 0.1186 ± 0.0007(st...

  15. Successful Ultra-Conservative Management of a Mandibular Premolar with Dens Invaginatus.

    Science.gov (United States)

    Abazarpour, Ramin; Parirokh, Masoud; Farhadi, Aida; Jalali, Zahra; Kheirabadi, Nasir

    2017-01-01

    Dens invaginatus is one of the most common anomalies of tooth structure. It is caused by the invagination of the crown surface during odontogenesis that enters the pulp chamber of the affected tooth. Depending on the complexity of invagination, the tooth might present with pulp necrosis, open apex and a complicated root canal system. This case report presents an Oehlers' type 2 dens-invaginatus in a mandibular premolar with chronic apical abscess. In most cases, dens invaginatus is removed during treatment. However, in this case report, based on cone-beam computed tomography (CBCT) evaluation, non-surgical treatment and maintenance of the invaginated segment was chosen in order to prevent compromising the tooth structure and its susceptibility to future root fracture. This is a new treatment approach and has not been performed in previous reports. Calcium-enriched mixture (CEM) cement was used as an apical plug followed by gutta-percha in warm vertical compaction for root canal obturation. The case was followed up for 36 months after treatment. This report highlights the importance of selecting the appropriate treatment approach based on CBCT evaluation.

  16. Vector competence of Aedes albopictus and Aedes aegypti (Diptera: Culicidae) for the DEN2-FJ10 and DEN2-FJ11 strains of the dengue 2 virus in Fujian, China.

    Science.gov (United States)

    Guo, Xiao-Xia; Li, Chun-Xiao; Zhang, Ying-Mei; Xing, Dan; Dong, Yan-De; Zhang, Heng-Duan; Qin, Cheng-Feng; Zhao, Tong-Yan

    2016-09-01

    Dengue is an acute, emerging, infectious disease transmitted by Aedes mosquitoes that has become a serious global public health problem. The DEN2-FJ10 and DEN2-FJ11 strains of the dengue 2 virus were originally isolated from the serum of a patient with dengue fever in Fujian Province, China, in 1999. Our data provide the first assessment of the vector competence of Aedes mosquitoes with respect to the DEN2-FJ10 and DEN2-FJ11 strains of the dengue virus. There were significant differences in the replication rates of these two viral strains in Aedes albopictus and Aedes aegypti (P0.05). In summary, our results indicate that Ae. albopictus and Ae. aegypti mosquitoes are moderately competent vectors of the DEN2-FJ10 and DEN2-FJ11 strains of the dengue virus and provide the first evidence of the effect of these two viral strains on the vector competence of mosquitoes in China. Copyright © 2016 Elsevier B.V. All rights reserved.

  17. [Ulrike Plath. Esten und Deutsche in den baltischen Provinzen Russlands. Fremdheitskonstruktionen, Lebenswelten, Kolonialphantasien 1750-1850] / Lea Leppik

    Index Scriptorium Estoniae

    Leppik, Lea, 1962-

    2014-01-01

    Arvustus: Plath, Ulrike. Esten und Deutsche in den baltischen Provinzen Russlands. Fremdheitskonstruktionen, Lebenswelten, Kolonialphantasien 1750-1850 (Veröffentlichungen des Nordost-Institut, 11). Harrasowitz. Wiesbaden 2011.

  18. Catalogue of polar bear (Ursus maritimus) maternal den locations in the Beaufort Sea and neighboring regions, Alaska, 1910-2010

    Science.gov (United States)

    Durner, George M.; Fischbach, Anthony S.; Amstrup, Steven C.; Douglas, David C.

    2010-01-01

    This report presents data on the approximate locations and methods of discovery of 392 polar bear (Ursus maritimus) maternal dens found in the Beaufort Sea and neighboring regions between 1910 and 2010 that are archived by the U.S. Geological Survey, Alaska Science Center, Anchorage, Alaska. A description of data collection methods, biases associated with collection method, primary time periods, and spatial resolution are provided. Polar bears in the Beaufort Sea and nearby regions den on both the sea ice and on land. Standardized VHF surveys and satellite radio telemetry data provide a general understanding of where polar bears have denned in this region over the past 3 decades. Den observations made during other research activities and anecdotal reports from other government agencies, coastal residents, and industry personnel also are reported. Data on past polar bear maternal den locations are provided to inform the public and to provide information for natural resource agencies in planning activities to avoid or minimize interference with polar bear maternity dens.

  19. Thiamine potentiates chemoprotective effects of ibuprofen in DEN induced hepatic cancer via alteration of oxidative stress and inflammatory mechanism.

    Science.gov (United States)

    Afzal, Muhammad; Kazmi, Imran; Khan, Ruqaiyah; Rana, Poonam; Kumar, Vikas; Al-Abbasi, Fahad A; Zamzami, Mazin A; Anwar, Firoz

    2017-06-01

    Present study, was an effort to scrutinize the molecular and biochemical role of ibuprofen and thiamine combination in diethylnitrosamine (DEN)-induced HCC in Wistar rats. Single intraperitoneal injection of DEN (200 mg/kg) was used for induction of HCC in rats. The rats were divided into eight various groups. DEN induced rats were treated with pure ibuprofen (40 mg/kg) and thiamine in combination for the period of 12th weeks. The protocol was terminated after the 16th week. Exposure of DEN up-regulated the levels of different serum biochemical parameters, antioxidant enzyme level, Alfa-fetoprotein (AFP) and reduced the level of High density lipoprotein (HDL) in Wistar rats along with the alteration in pro-inflammatory cytokines viz., interlukin-6 (IL-6), Tumor necrosis factor (TNF-α) and Interleukin-1β (IL-1β) with decrease in body weight. Macroscopic evaluation, revealed DEN group rats confirmed the expansion of hepatic nodules, which were reduced by the individual treatment of ibuprofen and thiamine, but the synergistic treatment of ibuprofen and thiamine confirm the significant reduction of hepatic nodules. Further, this combination possesses the significant chemoprotective effect in DEN-induced HCC by restoring the hepatic enzymes and other biomarkers along with an alteration in pro-inflammatory cytokines. The above result concludes that ibuprofen and thiamine combination possess potent anti-cancerous activity. Copyright © 2017 Elsevier Inc. All rights reserved.

  20. Die Grundlagen der Arithmetik. Eine logisch mathematische Untersuchung über den Begriff der Zahl

    OpenAIRE

    Frege, Gottlob

    1996-01-01

    Auf die Frage, was die Zahl Eins sei, oder was das Zeichen 1 bedeute, wird man meistens die Antwort erhalten: nun, ein Ding. Und wenn man dann darauf aufmerksam macht, dass der Satz "die Zahl Eins ist ein Ding" keine Definition ist, weil auf der einen Seite der bestimmte Artikel, auf der andern der unbestimmte steht, dass er nur besagt, die Zahl Eins gehöre zu den Dingen, aber nicht, welches Ding sie sei, so wird man vielleicht aufgefordert, sich irgendein Ding zu wählen, das man Eins nenn...