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Sample records for demographic analysis showed

  1. Sequence Analysis in Demographic Research

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    Billari, Francesco C.

    2001-01-01

    Full Text Available EnglishThis paper examines the salient features of sequence analysis in demogrpahicresearch. The new approach allows a holistic perspective on life course analysis and is based on arepresentation of lives as sequences of states. Some of the methods for analyzing such data aresketched, from complex description to optimal matching ot monoethetic divisive algorithms. Afer ashort ilustration of a demographically-relevant example, the needs in terms of data collection and theopportunities of applying the same aproach to synthetic data are discussed.FrenchOn examine ici les principaux éléments de l’analyse par séquence endémographie. Cette nouvelle technique permet une perspective unifiée del’analyse du cours de la vie, en représentant la vie comme une série d’états.Certaines des méthodes pour de telles analyses sont décrites, en commençant parla description complexe, pour considérer ensuite les alignements optimales, etles algorithmes de division. Après un court exemple en démographie, onconsidère les besoins en données et les possibilités d’application aux donnéessynthétique.

  2. 3D face analysis for demographic biometrics

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    Tokola, Ryan A [ORNL; Mikkilineni, Aravind K [ORNL; Boehnen, Chris Bensing [ORNL

    2015-01-01

    Despite being increasingly easy to acquire, 3D data is rarely used for face-based biometrics applications beyond identification. Recent work in image-based demographic biometrics has enjoyed much success, but these approaches suffer from the well-known limitations of 2D representations, particularly variations in illumination, texture, and pose, as well as a fundamental inability to describe 3D shape. This paper shows that simple 3D shape features in a face-based coordinate system are capable of representing many biometric attributes without problem-specific models or specialized domain knowledge. The same feature vector achieves impressive results for problems as diverse as age estimation, gender classification, and race classification.

  3. High-throughput oncogene mutation profiling shows demographic differences in BRAF mutation rates among melanoma patients.

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    van den Hurk, Karin; Balint, Balazs; Toomey, Sinead; O'Leary, Patrick C; Unwin, Louise; Sheahan, Kieran; McDermott, Enda W; Murphy, Ian; van den Oord, Joost J; Rafferty, Mairin; FitzGerald, Dara M; Moran, Julie; Cummins, Robert; MacEneaney, Owen; Kay, Elaine W; O'Brien, Cathal P; Finn, Stephen P; Heffron, Cynthia C B B; Murphy, Michelle; Yela, Ruben; Power, Derek G; Regan, Padraic J; McDermott, Clodagh M; O'Keeffe, Allan; Orosz, Zsolt; Donnellan, Paul P; Crown, John P; Hennessy, Bryan T; Gallagher, William M

    2015-06-01

    Because of advances in targeted therapies, the clinical evaluation of cutaneous melanoma is increasingly based on a combination of traditional histopathology and molecular pathology. Therefore, it is necessary to expand our knowledge of the molecular events that accompany the development and progression of melanoma to optimize clinical management. The central objective of this study was to increase our knowledge of the mutational events that complement melanoma progression. High-throughput genotyping was adapted to query 159 known single nucleotide mutations in 33 cancer-related genes across two melanoma cohorts from Ireland (n=94) and Belgium (n=60). Results were correlated with various clinicopathological characteristics. A total of 23 mutations in 12 genes were identified, that is--BRAF, NRAS, MET, PHLPP2, PIK3R1, IDH1, KIT, STK11, CTNNB1, JAK2, ALK, and GNAS. Unexpectedly, we discovered significant differences in BRAF, MET, and PIK3R1 mutations between the cohorts. That is, cases from Ireland showed significantly lower (PBRAF(V600E) mutation rates (19%) compared with the mutation frequency observed in Belgian patients (43%). Moreover, MET mutations were detected in 12% of Irish cases, whereas none of the Belgian patients harbored these mutations, and Irish patients significantly more often (P=0.027) had PIK3R1-mutant (33%) melanoma versus 17% of Belgian cases. The low incidence of BRAF(V600E)(-) mutant melanoma among Irish patients was confirmed in five independent Irish cohorts, and in total, only 165 of 689 (24%) Irish cases carried mutant BRAF(V600E). Together, our data show that melanoma-driving mutations vary by demographic area, which has important implications for the clinical management of this disease.

  4. Who Enters Campus Recreation Facilities: A Demographic Analysis

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    Paul Rohe Milton

    2011-06-01

    Full Text Available The purpose of this study was to examine student entry into a campus recreation center based on seven demographics (gender, ethnicity, age, class standing, intercollegiate athlete vs. non-athlete, students with self-reported disability vs. non-disability, and campus residence in order to determine who would be most likely to enter the recreation center. Subjects were from a mid-western, four year state-assisted institution with combined enrollment of 23,932 undergraduate and graduate students. Of the 23,932 enrolled, 14,032 students were examined in this study. Information on student entry to the recreation center was collected through the university’s student information system. Data was analyzed and interpreted using chi-square analysis. Results of the study show statistically significant differences in the demographics except the student disability demographic. More males than females, more African Americans than other ethnicities, more traditionally aged (18-25 students than non-traditional students, more underclassmen than seniors, more athletes and non-athletes, more residents than commuters were likely to enter the campus recreation center. The findings in this study could be used by collegiate recreational sport directors and administrators, in the United States and internationally, for future ideas about programming in similar recreation settings.

  5. Demographic changes in towns of Central Serbia: Comparative analysis

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    Filipović Marko

    2007-01-01

    Full Text Available Due to intensive urbanization, Central Serbia's urban population reached almost 60% in the total population. Despite the fact that the urban residents share in Serbia is still bellow the level of urbanization in developed countries, in which the percentage of urban residents exudes 70% (in majority of cases even more than 80%, it is an impression that demographic "resources" of rural areas have bean rather exhausted and that all demographic revitalization potential of Central Serbia is concentrated in towns. This paper treats the demographic changes which encompassed the towns of Central Serbia since 1981 census onwards, with special emphasis on the population migrations as well as on the natural growth, i.e. age - gender structure formation featuring the towns of Central Serbia. The changes will be analyzed trough a comparative analysis at the level of small, medium sized towns and big cities, while Belgrade will be represent as a special category.

  6. Demographic analysis reveals gradual senescence in the flatworm Macrostomum lignano

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    Braeckman Bart P

    2009-07-01

    Full Text Available Abstract Free-living flatworms ("Turbellaria" are appropriate model organisms to gain better insight into the role of stem cells in ageing and rejuvenation. Ageing research in flatworms is, however, still scarce. This is partly due to culture difficulties and the lack of a complete set of demographic data, including parameters such as median lifespan and age-specific mortality rate. In this paper, we report on the first flatworm survival analysis. We used the species Macrostomum lignano, which is an emerging model for studying the reciprocal influence between stem cells, ageing and rejuvenation. This species has a median lifespan of 205 ± 13 days (average ± standard deviation [SD] and a 90th percentile lifespan of 373 ± 32 days. The maximum lifespan, however, is more than 745 days, and the average survival curve is characterised by a long tail because a small number of individuals lives twice as long as 90% of the population. Similar to earlier observations in a wide range of animals, in M. lignano the age-specific mortality rate increases exponentially, but levels off at the oldest ages. To compare the senescence of M. lignano with that of other ageing models, we determined the mortality rate doubling time, which is 0.20 ± 0.02 years. As a result, we can conclude that M. lignano shows gradual senescence at a rate similar to the vertebrate ageing models Rattus norvegicus and Mus musculus. We argue that M. lignano is a suitable model for ageing and rejuvenation research, and especially for the role of stem cells in these processes, due to its accessible stem cell system and regeneration capacity, and the possibility of combining stem cell studies with demographic analyses.

  7. Climate change threatens polar bear populations: a stochastic demographic analysis.

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    Hunter, Christine M; Caswell, Hal; Runge, Michael C; Regehr, Eric V; Amstrup, Steve C; Stirling, Ian

    2010-10-01

    The polar bear (Ursus maritimus) depends on sea ice for feeding, breeding, and movement. Significant reductions in Arctic sea ice are forecast to continue because of climate warming. We evaluated the impacts of climate change on polar bears in the southern Beaufort Sea by means of a demographic analysis, combining deterministic, stochastic, environment-dependent matrix population models with forecasts of future sea ice conditions from IPCC general circulation models (GCMs). The matrix population models classified individuals by age and breeding status; mothers and dependent cubs were treated as units. Parameter estimates were obtained from a capture-recapture study conducted from 2001 to 2006. Candidate statistical models allowed vital rates to vary with time and as functions of a sea ice covariate. Model averaging was used to produce the vital rate estimates, and a parametric bootstrap procedure was used to quantify model selection and parameter estimation uncertainty. Deterministic models projected population growth in years with more extensive ice coverage (2001-2003) and population decline in years with less ice coverage (2004-2005). LTRE (life table response experiment) analysis showed that the reduction in lambda in years with low sea ice was due primarily to reduced adult female survival, and secondarily to reduced breeding. A stochastic model with two environmental states, good and poor sea ice conditions, projected a declining stochastic growth rate, log lambdas, as the frequency of poor ice years increased. The observed frequency of poor ice years since 1979 would imply log lambdas approximately - 0.01, which agrees with available (albeit crude) observations of population size. The stochastic model was linked to a set of 10 GCMs compiled by the IPCC; the models were chosen for their ability to reproduce historical observations of sea ice and were forced with "business as usual" (A1B) greenhouse gas emissions. The resulting stochastic population

  8. Evacuee Compliance Behavior Analysis using High Resolution Demographic Information

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    Lu, Wei [ORNL; Han, Lee [University of Tennessee, Knoxville (UTK); Liu, Cheng [ORNL; Tuttle, Mark A [ORNL; Bhaduri, Budhendra L [ORNL

    2014-01-01

    The purpose of this study is to examine whether evacuee compliance behavior with route assignments from different resolutions of demographic data would impact the evacuation performance. Most existing evacuation strategies assume that travelers will follow evacuation instructions, while in reality a certain percent of evacuees do not comply with prescribed instructions. In this paper, a comparison study of evacuation assignment based on Traffic Analysis Zones (TAZ) and high resolution LandScan USA Population Cells (LPC) were conducted for the detailed road network representing Alexandria, Virginia. A revised platform for evacuation modeling built on high resolution demographic data and activity-based microscopic traffic simulation is proposed. The results indicate that evacuee compliance behavior affects evacuation efficiency with traditional TAZ assignment, but it does not significantly compromise the efficiency with high resolution LPC assignment. The TAZ assignment also underestimates the real travel time during evacuation, especially for high compliance simulations. This suggests that conventional evacuation studies based on TAZ assignment might not be effective at providing efficient guidance to evacuees. From the high resolution data perspective, traveler compliance behavior is an important factor but it does not impact the system performance significantly. The highlight of evacuee compliance behavior analysis should be emphasized on individual evacuee level route/shelter assignments, rather than the whole system performance.

  9. Demographic analysis from summaries of an age-structured population

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    Link, William A.; Royle, J. Andrew; Hatfield, Jeff S.

    2003-01-01

    Demographic analyses of age-structured populations typically rely on life history data for individuals, or when individual animals are not identified, on information about the numbers of individuals in each age class through time. While it is usually difficult to determine the age class of a randomly encountered individual, it is often the case that the individual can be readily and reliably assigned to one of a set of age classes. For example, it is often possible to distinguish first-year from older birds. In such cases, the population age structure can be regarded as a latent variable governed by a process prior, and the data as summaries of this latent structure. In this article, we consider the problem of uncovering the latent structure and estimating process parameters from summaries of age class information. We present a demographic analysis for the critically endangered migratory population of whooping cranes (Grus americana), based only on counts of first-year birds and of older birds. We estimate age and year-specific survival rates. We address the controversial issue of whether management action on the breeding grounds has influenced recruitment, relating recruitment rates to the number of seventh-year and older birds, and examining the pattern of variation through time in this rate.

  10. The People's Show: A Critical Analysis

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    Robin Francis

    1996-01-01

    The 1990s heralded a new form of museum exhibition: "The People's Show." A light-hearted celebration of popular culture, the concept has had phenomenal success throughout the United Kingdom. Beneath the humour, however, are more complex and radical agendas relating to cultural rights. The paper explores the issues associated with the rise and possible wane of this museum-based popular cultural phenomenon.

  11. ANALYSIS OF THE DEMOGRAPHIC POTENTIAL IN FUNCTION OF TOURISM

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    Mijalce Gjorgievski

    2011-06-01

    Full Text Available Man is the prime mover of the overall social economic and political life of the entire globe and therefore he is studied from various aspects depending on the needs of what we want to obtain information on the demographic potential and its features.In this paper, the subject of study will be processing potential through its demographic characteristics (number condition, age structure, natural increase, economic activity, religious composition, etc. for the tourism economy. We know that the basic elements of tourism are the natural and cultural wealth that detect, evaluate and put into operation in tourism. However, it has its function, the basic factor are the people who need to visit those places, so it is very important to understand the demographic characteristics of people in every region of the globe in order to come to some understanding of the habits, needs and affinities of people depending on age, nationality and religious affiliation, etc. when choosing their travel destination.

  12. Specialist and generalist symbionts show counterintuitive levels of genetic diversity and discordant demographic histories along the Florida Reef Tract

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    Titus, Benjamin M.; Daly, Marymegan

    2017-03-01

    Specialist and generalist life histories are expected to result in contrasting levels of genetic diversity at the population level, and symbioses are expected to lead to patterns that reflect a shared biogeographic history and co-diversification. We test these assumptions using mtDNA sequencing and a comparative phylogeographic approach for six co-occurring crustacean species that are symbiotic with sea anemones on western Atlantic coral reefs, yet vary in their host specificities: four are host specialists and two are host generalists. We first conducted species discovery analyses to delimit cryptic lineages, followed by classic population genetic diversity analyses for each delimited taxon, and then reconstructed the demographic history for each taxon using traditional summary statistics, Bayesian skyline plots, and approximate Bayesian computation to test for signatures of recent and concerted population expansion. The genetic diversity values recovered here contravene the expectations of the specialist-generalist variation hypothesis and classic population genetics theory; all specialist lineages had greater genetic diversity than generalists. Demography suggests recent population expansions in all taxa, although Bayesian skyline plots and approximate Bayesian computation suggest the timing and magnitude of these events were idiosyncratic. These results do not meet the a priori expectation of concordance among symbiotic taxa and suggest that intrinsic aspects of species biology may contribute more to phylogeographic history than extrinsic forces that shape whole communities. The recovery of two cryptic specialist lineages adds an additional layer of biodiversity to this symbiosis and contributes to an emerging pattern of cryptic speciation in the specialist taxa. Our results underscore the differences in the evolutionary processes acting on marine systems from the terrestrial processes that often drive theory. Finally, we continue to highlight the Florida Reef

  13. Demographic Analysis and Planning for the Future. No. 13.

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    Efird, Cathy M.

    The basic sources and types of demographic data available for future planning for the developmentally disabled are reviewed and a frame work for data organization is suggested. It is explained that future forecasts may be undertaken by the following principles: trend forecasting or extrapolation; scenario construction; models, games, and…

  14. Disability Prevalence and Correlates in Pakistan: A Demographic Analysis

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    Mohammad Afzal

    1992-01-01

    The paper provides a demographic view of disability patterns in Pakistan, and also highlights the inadequacies and inconsistencies of data, especially those provided by the census. Besides assessing the prevalence of disability by age, gender considerations, nature of disability and reasons of disability, the paper examines such features among the disabled population as their work participation, training, self-sufficiency and dependence on the help of the others. Even though the estimates of ...

  15. Demographic characteristics of exploited tropical lutjanids: a comparative analysis

    OpenAIRE

    Heupel, Michelle R.; Williams, Ashley A.; David J. Welch; Campbell R. Davies; Penny, Ann; Jacob P Kritzer; Marriott, Ross J.; Bruce D. Mapstone

    2010-01-01

    Demographic parameters from seven exploited coral reef lutjanid species were compared as a case study of the implications of intrafamily variation in life histories for multispecies harvest management. Modal lengths varied by 4 cm among four species (Lutjanus fulviflamma, L. vitta, L. carponotatus, L. adetii), which were at least 6 cm smaller than the modal lengths of the largest species (L. gibbus, Symphorus nematophorus, Aprion virescens). Modal ages, indicating ages of full selection to...

  16. [Demographic analysis of the blue shark, Prionace glauca, in the North Atlantic Ocean].

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    Gao, Chun-xia; Dai, Xiao-jie; Tian, Si-quan; Wu, Feng; Zhu, Jiang-feng

    2016-02-01

    The blue shark, Prionace glauca, is the main by-catch species in tuna longline fishery. As one of top species in the oceanic food webs, the blue shark plays an important role in the marine ecosystem. Traditional stock assessment methods are difficult to accurately evaluate the population dynamic for this shark because of limited data. Based on life-history parameters of the blue shark in the North Atlantic, demographic analysis was employed to estimate the demographic parameters and evaluate the potential exploitation for the blue shark. Moreover, we discussed the relationship between age at first capture and critical value of fishing mortality corresponding to the value of intrinsic rate of natural increase 0. The results showed that the survival rate (S) of blue shark from 0.719 to 0.820, intrinsic rate of natural increase (r0) from 0.250 to 0.381, time of population doubling (tx2) from 1.819 to 2.773 years, reproduction rate per generation (R0) from 6.600 to 22.255, and generation time (G) from 8.498 to 10.162 years. The sensitivity analysis for the life history parameters revealed that the uncertainties of natural mortality existed in the first age class, age at maturity and maximum age had slight influence on the demographic parameters. Fishing mortality (Fc) increased with the age at first capture. When the age at first capture (tc) was more than five, there was no obvious relationship between Fc and tc.

  17. Reconstruction of a beech population bottleneck using archival demographic information and Bayesian analysis of genetic data.

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    Lander, Tonya A; Oddou-Muratorio, Sylvie; Prouillet-Leplat, Helene; Klein, Etienne K

    2011-12-01

    Range expansion and contraction has occurred in the history of most species and can seriously impact patterns of genetic diversity. Historical data about range change are rare and generally appropriate for studies at large scales, whereas the individual pollen and seed dispersal events that form the basis of geneflow and colonization generally occur at a local scale. In this study, we investigated range change in Fagus sylvatica on Mont Ventoux, France, using historical data from 1838 to the present and approximate Bayesian computation (ABC) analyses of genetic data. From the historical data, we identified a population minimum in 1845 and located remnant populations at least 200 years old. The ABC analysis selected a demographic scenario with three populations, corresponding to two remnant populations and one area of recent expansion. It also identified expansion from a smaller ancestral population but did not find that this expansion followed a population bottleneck, as suggested by the historical data. Despite a strong support to the selected scenario for our data set, the ABC approach showed a low power to discriminate among scenarios on average and a low ability to accurately estimate effective population sizes and divergence dates, probably due to the temporal scale of the study. This study provides an unusual opportunity to test ABC analysis in a system with a well-documented demographic history and identify discrepancies between the results of historical, classical population genetic and ABC analyses. The results also provide valuable insights into genetic processes at work at a fine spatial and temporal scale in range change and colonization.

  18. Sensitivity analysis of effective population size to demographic parameters in house sparrow populations.

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    Stubberud, Marlene Waege; Myhre, Ane Marlene; Holand, Håkon; Kvalnes, Thomas; Ringsby, Thor Harald; Saether, Bernt-Erik; Jensen, Henrik

    2017-02-16

    The ratio between the effective and the census population size, Ne/N, is an important measure of the long-term viability and sustainability of a population. Understanding which demographic processes that affect Ne/N most will improve our understanding of how genetic drift and the probability of fixation of alleles is affected by demography. This knowledge may also be of vital importance in management of endangered populations and species. Here, we use data from 13 natural populations of house sparrow (Passer domesticus) in Norway to calculate the demographic parameters that determine Ne/N. Using the global variance-based Sobol' method for the sensitivity analyses, we found that Ne/N was most sensitive to demographic variance, especially among older individuals. Furthermore, the individual reproductive values (that determine the demographic variance) were most sensitive to variation in fecundity. Our results draw attention to the applicability of sensitivity analyses in population management and conservation. For population management aiming to reduce the loss of genetic variation, a sensitivity analysis may indicate the demographic parameters towards which resources should be focused. The result of such an analysis may depend on the life history and mating system of the population or species under consideration, because the vital rates and sex-age classes that Ne/N is most sensitive to may change accordingly.

  19. Sexual assault victims in the emergency department: analysis by demographic and event characteristics.

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    Avegno, Jennifer; Mills, Trevor J; Mills, Lisa D

    2009-10-01

    The objective of this study was to analyze demographic and event characteristics of patients presenting to the Emergency Department (ED) for evaluation after sexual assault, using a Sexual Assault Nurse Examiner standardized database. Data were prospectively collected as part of the Sexual Assault Nurse Examiner program at an urban teaching hospital. This study reviewed all ED patient records with a complaint of sexual assault between January 1, 2000 and December 31, 2004. Data were collected on 1172 patients; 92.6% were women, with a mean age of 27 years. The sample was 59.1% black, 38.6% white, and 2.3% "Other." Black victims of sexual assault were significantly more likely to be young (25 years or less) than Whites. Over half (54%) reported involvement of drugs or alcohol during the event. Fifty-three percent knew their assailant(s), and black and young patients were significantly more likely to know the perpetrator(s). Threats of force were common (72.4% of sample), and multiple assailants were uncommon (18.1% of sample). Physical evidence of trauma was present in more than half (51.7%), with increased rates among Whites and older persons. Multivariate analysis showed that race, age, threats, and substance use during the event were independent risk factors for evident trauma on physical examination. Survivors of sexual assault who present to the ED are overwhelmingly female, relatively young, often know the perpetrator of the event, and are likely to be threatened and show signs of physical trauma. Differences between patients according to demographic and event characteristics may have important implications for ED management and treatment plans.

  20. Effects of climate change on an emperor penguin population: analysis of coupled demographic and climate models.

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    Jenouvrier, Stéphanie; Holland, Marika; Stroeve, Julienne; Barbraud, Christophe; Weimerskirch, Henri; Serreze, Mark; Caswell, Hal

    2012-09-01

    Sea ice conditions in the Antarctic affect the life cycle of the emperor penguin (Aptenodytes forsteri). We present a population projection for the emperor penguin population of Terre Adélie, Antarctica, by linking demographic models (stage-structured, seasonal, nonlinear, two-sex matrix population models) to sea ice forecasts from an ensemble of IPCC climate models. Based on maximum likelihood capture-mark-recapture analysis, we find that seasonal sea ice concentration anomalies (SICa ) affect adult survival and breeding success. Demographic models show that both deterministic and stochastic population growth rates are maximized at intermediate values of annual SICa , because neither the complete absence of sea ice, nor heavy and persistent sea ice, would provide satisfactory conditions for the emperor penguin. We show that under some conditions the stochastic growth rate is positively affected by the variance in SICa . We identify an ensemble of five general circulation climate models whose output closely matches the historical record of sea ice concentration in Terre Adélie. The output of this ensemble is used to produce stochastic forecasts of SICa , which in turn drive the population model. Uncertainty is included by incorporating multiple climate models and by a parametric bootstrap procedure that includes parameter uncertainty due to both model selection and estimation error. The median of these simulations predicts a decline of the Terre Adélie emperor penguin population of 81% by the year 2100. We find a 43% chance of an even greater decline, of 90% or more. The uncertainty in population projections reflects large differences among climate models in their forecasts of future sea ice conditions. One such model predicts population increases over much of the century, but overall, the ensemble of models predicts that population declines are far more likely than population increases. We conclude that climate change is a significant risk for the emperor

  1. "Demographic faultlines: A meta-analysis of the literature": Retraction of Thatcher and Patel (2011).

    Science.gov (United States)

    2016-08-01

    Reports the retraction of "Demographic faultlines: A meta-analysis of the literature" by Sherry M. B. Thatcher and Pankaj C. Patel (, 2011[Nov], Vol 96[6], 1119-1139). At the request of the editor and in consultation with the American Psychological Association, the article is being retracted. This action is a result of a review by the editor and two additional experts that determined that there are significant errors in Tables 1, 2, and 3 which may affect the overall conclusions of the article. Co-author Pankaj C. Patel led the analysis, and both authors acknowledge that inaccuracies were made. The retraction of this article does not preclude resubmission of a new article that addresses the issues noted in the retraction. (The following abstract of the original article appeared in record .) We propose and test a theoretical model focusing on antecedents and consequences of demographic faultlines. We also posit contingencies that affect overall team dynamics in the context of demographic faultlines, such as the study setting and performance measurement. Using meta-analysis structural equation modeling with a final data set consisting of 311 data points (i.e., [predictor-criterion relationships]), from 39 studies that were obtained from 36 papers with a total sample size of 24,388 individuals in 4,366 teams, we found that sex and racial diversity increased demographic faultline strength more than did diversity on the attributes of functional background, educational background, age, and tenure. Demographic faultline strength was found to increase task and relationship conflict as well as decrease team cohesion. Furthermore, although demographic faultline strength decreased both team satisfaction and team performance, there was a stronger decrease in team performance than in team satisfaction. The strength of these relationships increased when the study was conducted in the lab rather than in the field. We describe the theoretical and practical implications of these

  2. Retrospective Analysis of Patient Presentations at the Sydney (Australia) Royal Easter Show from 2012 to 2014.

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    Crabtree, Nathan; Mo, Shirley; Ong, Leon; Jegathees, Thuvarahan; Wei, Daniel; Fahey, David; Liu, Jia Jenny

    2017-04-01

    Introduction Comprehensive studies on the relationship between patient demographics and subsequent treatment and disposition at a single mass-gathering event are lacking. The Sydney Royal Easter Show (SRES; Sydney Olympic Park, New South Wales, Australia) is an annual, 14-day, agricultural mass-gathering event occurring around the Easter weekend, attracting more than 800,000 patrons per year. In this study, patient records from the SRES were analyzed to examine relationships between weather, crowd size, day of week, and demographics on treatment and disposition. This information would help to predict factors affecting patient treatment and disposition to guide ongoing training of first responders and to evaluate the appropriateness of staffing skills mix at future events. Hypothesis Patient demographics, environmental factors, and attendance would influence the nature and severity of presentations at the SRES, which would influence staffing requirements. A retrospective analysis of 4,141 patient record forms was performed for patients who presented to St John Ambulance (Australian Capital Territory, Australia) at the SRES between 2012 and 2014 inclusive. Presentation type was classified using a previously published minimum data set. Data on weather and crowd size were obtained from the Australian Bureau of Meteorology (Melbourne, Victoria, Australia) and the SRES, respectively. Statistical analyses were performed using SPSS v22 (IBM; Armonk, New York USA). Between 2012 to 2014, over 2.5 million people attended the SRES with 4,141 patients treated onsite. As expected, the majority of presentations were injuries (49%) and illnesses (46%). Although patient demographics and presentation types did not change over time, the duration of treatment increased. A higher proportion of patients were discharged to hospital or home compared to the proportion of patients discharged back to the event. Patients from rural/regional locations (accounting for 15% of all patients) were

  3. Snacking on Television: A Content Analysis of Adolescents’ Favorite Shows

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    Larson, Nicole I.; Gollust, Sarah E.; Neumark-Sztainer, Dianne

    2016-01-01

    Introduction Snacking is a complex behavior that may be influenced by entertainment media. Research suggests that snacking and unhealthy foods are commonly shown in programming that targets young audiences, but shows selected for study have been limited. We conducted a content analysis on shows that were named as favorites by adolescents to characterize portrayals of snacking on popular television. Methods A diverse sample of 2,130 adolescents (mean age, 14.3 y) listed 3 favorite television shows in a 2010 school-based survey. Three episodes each of the 25 most popular shows were coded for food-related content, including healthfulness, portion size, screen time use, setting, and social context. We also analyzed the characteristics of characters involved in eating incidents, the show type, and the show rating. We used χ2 tests, binomial tests, and multilevel regression models to compare incidence of snacks versus meals, the characteristics of those involved, and snacking across show characteristics. Results Almost half of food incidents on television shows were snacks. Snacks were significantly more likely than meals to be “mostly unhealthy” (69.3% vs 22.6%, P Sitcoms and shows rated for a youth audience were significantly more likely to portray snacking than were shows for adult audiences. Conclusion Media awareness and literacy programs should include foods and snacking behaviors among the issues they address. More healthful portrayals of food and dietary intake in entertainment shows’ content would create a healthier media environment for youth. PMID:27197079

  4. Proximate Determinants of Fertility in Zambia: Analysis of the 2007 Zambia Demographic and Health Survey

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    Mumbi Chola

    2016-01-01

    Full Text Available The role of proximate determinants in influencing fertility has been well documented worldwide. Bongaarts’ aggregate model of the proximate determinants (which focuses on marriage, contraception, abortion, and sterility has been widely used to analyse the influence of proximate determinants on fertility. In Zambia, however, there is limited understanding of their effects. Therefore, the aim of this study was to examine the effect of proximate determinants of fertility in Zambia using Bongaarts’ model. This was a cross-sectional analysis of women’s data from the 2007 Zambia Demographic and Health Survey (ZDHS. A total of 7,146 women aged 15 to 49 years participated in the ZDHS. Bongaarts’ model was employed in the data analysis. Results showed that, overall, mean age was 27.8 years and rural-urban distribution was 56% and 44%, respectively. Marriage (40% and postpartum infecundity (22% accounted for the largest inhibiting effect on natural fertility from its biological maximum of 19.10. Contraception use accounted for only 3%. Therefore, in order to manage fertility in Zambia, policies and programmes should consider the effects of marriage, postpartum infecundity, and contraception on fertility. Without such targeted interventions, managing and maintaining population growth will remain a challenge in Zambia.

  5. Genetic analysis reveals demographic fragmentation of grizzly bears yielding vulnerably small populations.

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    Proctor, Michael F; McLellan, Bruce N; Strobeck, Curtis; Barclay, Robert M R

    2005-11-22

    Ecosystem conservation requires the presence of native carnivores, yet in North America, the distributions of many larger carnivores have contracted. Large carnivores live at low densities and require large areas to thrive at the population level. Therefore, if human-dominated landscapes fragment remaining carnivore populations, small and demographically vulnerable populations may result. Grizzly bear range contraction in the conterminous USA has left four fragmented populations, three of which remain along the Canada-USA border. A tenet of grizzly bear conservation is that the viability of these populations requires demographic linkage (i.e. inter-population movement of both sexes) to Canadian bears. Using individual-based genetic analysis, our results suggest this demographic connection has been severed across their entire range in southern Canada by a highway and associated settlements, limiting female and reducing male movement. Two resulting populations are vulnerably small (bear populations may be more threatened than previously thought and that conservation efforts must expand to include international connectivity management. They also demonstrate the ability of genetic analysis to detect gender-specific demographic population fragmentation in recently disturbed systems, a traditionally intractable yet increasingly important ecological measurement worldwide.

  6. Demographic Models for Projecting Population and Migration: Methods for African Historical Analysis

    Directory of Open Access Journals (Sweden)

    Patrick Manning

    2015-08-01

    Full Text Available This study presents methods for projecting population and migration over time in cases were empirical data are missing or undependable. The methods are useful for cases in which the researcher has details of population size and structure for a limited period of time (most obviously, the end point, with scattered evidence on other times. It enables estimation of population size, including its structure in age, sex, and status, either forward or backward in time. The program keeps track of all the details. The calculated data can be reported or sampled and compared to empirical findings at various times and places to expected values based on other procedures of estimation. The application of these general methods that is developed here is the projection of African populations backwards in time from 1950, since 1950 is the first date for which consistently strong demographic estimates are available for national-level populations all over the African continent. The models give particular attention to migration through enslavement, which was highly important in Africa from 1650 to 1900. Details include a sensitivity analysis showing relative significance of input variables and techniques for calibrating various dimensions of the projection with each other. These same methods may be applicable to quite different historical situations, as long as the data conform in structure to those considered here.

  7. Total Factor Productivity, Demographic Traits and ICT: Empirical Analysis for Asia

    Directory of Open Access Journals (Sweden)

    Bilal MEHMOOD

    2014-01-01

    Full Text Available This paper advances a model to explain the total factor productivity in Asian countries, most of which are labor surplus and are endowed with substantial human capital. Such promising demographic potentials are considered as complementary factors to use of Information and Communication Technology (ICT. Population with such favorable demographic traits and access to ICT results in higher Total factor productivity (TFP. We call this as Demo-Tech-TFP Model and is tested by using data for 2000-2010 of 24 Asian countries. Econometric concerns like presence of endogenous and/or predetermined covariates and small time-series and cross-sectional dimensions of panel dataset are tackled by using System Generalized Method of Moments (SYS-GMM. Results show considerable support for the Demo-Tech-TFP hypothesis. Need is to design such models that suit the local demography and patterns of technological diffusion currently taking place in developing countries.

  8. Association between Maternal and Child Dietary Diversity: An Analysis of the Ghana Demographic and Health Survey.

    Directory of Open Access Journals (Sweden)

    Dickson Abanimi Amugsi

    Full Text Available This study examined the association between maternal and child dietary diversity in a population-based national sample in Ghana.The data for this analysis are from the 2008 Ghana Demographic and Health Survey. We used data obtained from 1187 dyads comprised of mothers' ages 15-49 and their youngest child (ages 6-36 months. Maternal and child dietary diversity scores (DDS were created based on the mother's recall of her own and her child's consumption of 15 food groups, during the 24 hours prior to the in-home survey. The same food groups were used to compose both maternal and child DDS. Linear regression was used to assess the relationship between the predicted outcome--child DDS--and maternal DDS, taking into account child age and sex, maternal factors (age, education, occupation, literacy, empowerment, number of antenatal visits as an indicator of health care use, household Wealth Index, and urban/rural place of residence.There was a statistically significant positive association between child and maternal DDS, after adjusting for all other variables. A difference of one food group in mother's consumption was associated with a difference of 0.72 food groups in the child's food consumption (95% CI: 0.63, 0.82. Also, statistically significant positive associations were observed such that higher child DDS was associated with older child age, and with greater women's empowerment.The results show a significant positive association between child and maternal DD, after accounting for the influence of child, maternal and household level factors. Since the likely path of influence is that maternal DDS impacts child DDS, public health efforts to improve child health may be strengthened by promoting maternal DDS due to its potential for a widened effect on the entire family.

  9. Motor neuron diseases in the university hospital of Fortaleza (Northeastern Brazil): a clinico-demographic analysis of 87 cases.

    Science.gov (United States)

    Castro-Costa, C M; Oriá, R B; Vale, O C; Arruda, J A; Horta, W G; D'Almeida, J A; Santos, T J; Ramos, R S; Gifoni, M A

    2000-12-01

    In this retrospective (1980-1998) study, we have analyzed clinico-demographically, from the records of the University Hospital of Fortaleza (Brazil), a group of 87 patients showing signs and symptoms of motor neuron diseases (MNDs). Their diagnosis was determined clinically and laboratorially. The WFN criteria were used for amyotrophic lateral sclerosis (ALS) diagnosis. The clinico-demographic analysis of the 87 cases of MNDs showed that 4 were diagnosed as spinal muscular atrophy (SMA), 5 cases as ALS subsets: 2 as progressive bulbar paralysis (PBP), 2 as progressive muscular atrophy (PMA) and 1 as monomelic amyotrophy (MA), and 78 cases of ALS. The latter comprised 51 males and 27 females, with a mean age of 42.02 years. They were sub-divided into 4 groups according to age: from 15 to 29 years (n= 17), 30 to 39 years (n= 18), 40 to 69 years (n= 39) and 70 to 78 years (n= 4). From the 78 ALS patients, 76 were of the classic sporadic form whilst only 2 were of the familial form. The analysis of the 87 patients with MNDs from the University Hospital of Fortaleza showed a predominance of ALS patients, with a high number of cases of juvenile and early onset adult sporadic ALS.

  10. Turnover and heterogeneity in top management networks - A demographic analysis of two Swedish business groups

    Directory of Open Access Journals (Sweden)

    Collin, S. & Umans, T.

    2008-09-01

    Full Text Available A theory based on the demography of top management teams is used to explain membership turnover in two Swedish business groups, network analysis being used to define group membership. The results suggest these business groups possess a combination of financial and industrial experience as a group resource and the socialising strategy of control as a force counteracting the conflict-producing force of heterogeneity. An organisational demographic perspective focusing on opposing forces of heterogeneity and homogeneity is developed. It is shown that the perspective can be applied both to formal organisations and to informal ones such as networks.

  11. Nonparametric bootstrap analysis with applications to demographic effects in demand functions.

    Science.gov (United States)

    Gozalo, P L

    1997-12-01

    "A new bootstrap proposal, labeled smooth conditional moment (SCM) bootstrap, is introduced for independent but not necessarily identically distributed data, where the classical bootstrap procedure fails.... A good example of the benefits of using nonparametric and bootstrap methods is the area of empirical demand analysis. In particular, we will be concerned with their application to the study of two important topics: what are the most relevant effects of household demographic variables on demand behavior, and to what extent present parametric specifications capture these effects." excerpt

  12. A National Study Assessing the Teaching and Learning of Introductory Astronomy; Part II: Analysis of Student Demographics

    Science.gov (United States)

    Prather, E. E.; Consiglio, D.; Rudolph, A. L.; Brissenden, G.

    2011-09-01

    This is the second in a series of reports on a national study of the teaching and learning of astronomy in general education, non-science major, introductory astronomy courses (Astro 101). We report here on the analysis of how individual student characteristics affect student learning in these classes, and whether the demonstrated positive effect of interactive learning strategies on student learning differs based on these characteristics. This analysis was conducted using data from nearly 2000 students enrolled in 69 Astro 101 classes taught across the country. These students completed a 15-question demographic survey, in addition to completing the 26-question Light and Spectroscopy Concept Inventory (LSCI) pre- and post-instruction. The LSCI was used to determine student learning via a normalized gain calculated for each student. A multivariate regression analysis was conducted to determine how ascribed characteristics (personal demographic and family characteristics), obtained characteristics (academic achievement and student major), and the use of interactive learning strategies predict student learning in these classes. The results show dramatic improvement in student learning with increased use of interactive learning strategies even after controlling for individual characteristics. In addition, we find that the positive effects of interactive learning strategies are the same for strong and weak students, men and women, across ethnicities, and regardless of primary language. The research strongly suggests all students benefit from interactive learning strategies.

  13. Advertising Discourse Analysis of FES stores: Killing Love, Cowards Show

    Directory of Open Access Journals (Sweden)

    Cristian Venegas Ahumada

    2013-08-01

    Full Text Available The objective is to analyze the structural and photographic discourse of the Autumn-Winter campaign 2008 of FES stores for young people. This was done by a semiotic theory and a critical-structural methodology of discourse. An analysis of 4 advertising photographs was done, and at once an analysis of the discourse “FES says no to violence against Women”, which explains the campaign’s target. The result is: The discourse was subjected to production condition (society of control and makes advertising a way to homogenize subjectivity of masses to consume. Recognition conditions demonstrate that this advertising discourse of symbolic violence means a type of violation of Men and Women Rights. An action like this requires commitment of Psychology in order to promote the social humanizing change, by means of university teaching and professional tasks.

  14. DEMOGRAPHIC SECURITY: THEORY, METHODOLOGY, EVALUATION

    Directory of Open Access Journals (Sweden)

    Mikhail V. Karmanov

    2015-01-01

    Full Text Available The paper analyzes the theoretical aspects of demographic security. Reviewed and analyzed the point of view of various scholars to the definition of demographic security. The main directions of statistical analysis of demographic security.

  15. Authenticity and TV Shows: A Multidimensional Analysis Perspective

    Science.gov (United States)

    Al-Surmi, Mansoor

    2012-01-01

    Television shows, especially soap operas and sitcoms, are usually considered by English as a second language practitioners as a source of authentic spoken conversational materials presumably because they reflect the linguistic features of natural conversation. However, practitioners are faced with the dilemma of how to assess whether such…

  16. Demographic-Based Content Analysis of Web-Based Health-Related Social Media

    OpenAIRE

    2016-01-01

    Background An increasing number of patients from diverse demographic groups share and search for health-related information on Web-based social media. However, little is known about the content of the posted information with respect to the users’ demographics. Objective The aims of this study were to analyze the content of Web-based health-related social media based on users’ demographics to identify which health topics are discussed in which social media by which demographic groups and to he...

  17. Structure analysis of the La Guajira-Colombia population: a genetic, demographic and genealogical overview.

    Science.gov (United States)

    Rojas, M Y; Alonso, L A; Sarmiento, V A; Eljach, L Y; Usaquén, W

    2013-03-01

    This study examined whether cultural factors, as compared to geographical distance, have produced a population sub-structure among different groups from the La Guajira population (Amerindian Wayúu and other resident groups) that co-exist within the same region. The aims of this study were to analyse this population to discover whether cultural barriers result in the sub-structure, to evaluate whether there is a genetic drift effect and to describe migration dynamics using a genetic, genealogical and demographic approach. This study examined a sample of 290 individuals who were grouped based on a genealogical criterion to distinguish between native individuals and migrants. Using demographic information, the age and gender structure of the population and genetic drift estimators were analysed. Using 15 autosomal microsatellites, heterozygosity, Hardy-Weinberg equilibrium (HWE), inbreeding, sub-structure, recent migration rate and genetic relationships were also evaluated using a Principal Component analysis (PCA) using reference populations. La Guajira is a young population that is growing and exposed to a moderate effect of genetic drift (Neme 11.903). The Wayúu are highly diverse (Ho 0.727) and different from other groups, with the exception of Wayúu-Guajiro. This trend was also observed in other Amerindian populations. This study found a high level of admixture and gene flow within the Wayúu population despite cultural differences. Thus, although the Wayúu population differs from other population groups, it is not an isolated population.

  18. An Empirical Analysis of Economic and Socio-Demographic Determinants of Entrepreneurship Across German Regions

    Directory of Open Access Journals (Sweden)

    Mrożewski Matthias

    2014-11-01

    Full Text Available Entrepreneurship is fundamental for a country's economic development through its positive effect on innovation, productivity growth, and job creation. In entrepreneurial research, one of the most important problems is to define the factors that actually determine entrepreneurial action. This study analyzes that question in the case of Germany by taking an aggregated approach that focuses on socio-demographic and economic determinants of regional entrepreneurship. Based on a literature review of German and international regional-level research, six hypotheses are developed and empirically tested using the most recent available data on 385 German regions as units of analysis. The results are surprising. In the case of household income, unemployment, education and marital status the relationship is significant but contrary to earlier research. Only regional age structure seems to be a stable predictor of regional entrepreneurship. The results indicate that in recent years there was a major shift in the determinants and characteristics of entrepreneurship in Germany.

  19. Persistent postmastectomy pain in breast cancer survivors: analysis of clinical, demographic, and psychosocial factors.

    Science.gov (United States)

    Belfer, Inna; Schreiber, Kristin L; Shaffer, John R; Shnol, Helen; Blaney, Kayleigh; Morando, Alexandra; Englert, Danielle; Greco, Carol; Brufsky, Adam; Ahrendt, Gretchen; Kehlet, Henrik; Edwards, Robert R; Bovbjerg, Dana H

    2013-10-01

    Persistent postmastectomy pain (PPMP) is increasingly recognized as a major individual and public health problem. Although previous studies have investigated surgical, medical, and demographic risk factors, in this study we aimed to more clearly elucidate the relationship of psychosocial factors to PPMP. Postmastectomy patients (611) were queried about pain location, severity, and burden 38.3 ± 35.4 months postoperatively. Validated questionnaires for depressive symptoms, anxiety, sleep, perceived stress, emotional stability, somatization, and catastrophizing were administered. Detailed surgical, medical, and treatment information was abstracted from patients' medical records. One third (32.5%) of patients reported PPMP, defined as ≥3/10 pain severity in the breast, axilla, side, or arm, which did not vary according to time since surgery. Multiple regression analysis revealed significant and independent associations between PPMP and psychosocial factors, including catastrophizing, somatization, anxiety, and sleep disturbance. Conversely, treatment-related factors including surgical type, axillary node dissection, surgical complication, recurrence, tumor size, radiation, and chemotherapy were not significantly associated with PPMP. These data confirm previous studies suggesting that PPMP is relatively common and provide new evidence of significant associations between psychosocial characteristics such as catastrophizing with PPMP, regardless of the surgical and medical treatment that patients receive, which may lead to novel strategies in PPMP prevention and treatment. This cross-sectional cohort study of 611 postmastectomy patients investigated severity, location, and frequency of pain a mean of 3.2 years after surgery. Significant associations between pain severity and individual psychosocial attributes such as catastrophizing were found, whereas demographic, surgical, medical, and treatment-related factors were not associated with persistent pain. Copyright

  20. Retrospective Demographic Analysis of Patients Seeking Care at a Free University Chiropractic Clinic

    Science.gov (United States)

    Stevens, Gerald; Campeanu, Michael; Sorrento, Andrew T.; Ryu, Jiwoon; Burke, Jeanmarie

    2016-01-01

    Objective The purpose of this study was to describe the demographics, presenting complaints, and health history of new patients seeking treatment at a free chiropractic clinic within a university health center. Methods A retrospective analysis of patient files from 2008 to 2009 was performed for a free student chiropractic clinic in the Buffalo, NY, area. Demographics, presenting complaints, and health history of new patients seeking treatment were recorded. Results There were 343 new chiropractic patient files. Most patients were between the ages of 18 and 30 years (n = 304, 88%) with an almost equal distribution of men (n = 163, 48%) and women (n = 180, 52%). The patients were mostly single (n = 300, 87%). Patients self-reported that their case histories excluded a current medical diagnosis (n = 261, 76%), previous history of disease (n = 216, 63%), allergies (n = 240, 70%), previous surgical procedures (n = 279, 81%), and medication use (n = 250, 73%). The frequencies of spinal complaints were as follows: lumbar spine, n = 176 (51%); cervical spine, n = 78 (23%); and thoracic spine, n = 44 (13%). Maintenance care, headaches, and spine-related upper and lower extremities complaints accounted for the other 13% of patients treated. Half were chronic (n = 172, 50%), and a third were acute (n=108, 31%). Patients averaged 6 chiropractic visits, with 88% having 11 visits or less. Conclusion This study found that new patients seeking care at a free student chiropractic clinic within a university health center in the Buffalo area mainly consisted of young single adults, with chronic lumbar spine complaints with few comorbidities. PMID:27069428

  1. [Impact of demographic chance on pharmaceutical expenses in private health insurance--a scenario-based analysis].

    Science.gov (United States)

    Böcking, W; Tidelski, O; Skuras, B; Bäumler, A; Kitzmann, F

    2012-08-01

    Health Insurance costs in Germany have grown constantly over the last years. This increase of costs is not only observable in the total consideration but also in all single items. An outstanding growth rate exists in the field of pharmaceutical expenses. Detailed analyses of distribution and development of these costs, separated by age and indication groups, are currently only sporadically available and mostly focusing on the Statutory Health Insurance system in Germany. This research article is based on an initial data analysis and focuses on the question how pharmaceutical expenses in a German private health insurance company will develop until the year 2050, if the observed trend of the past years continues in the same way. This analysis focuses on different age groups. The objective is the demonstration of several scenarios, which illustrate the level of influence of different parameters (demographic changes, developments of prices for pharmaceuticals). Based on the cognition of certain effects measures for handling the growing challenge of financing the health system can be deduced. As a result, both demographic changes and price effects have an significant impact on the future development of per capita pharmaceutical expenses. Whereas older age groups will still cause the highest costs, the middle-aged people will show the highest growth rates. This strong cost increase is not sustainable for the German health insurance system. In addition to previous measures of a regulatory health policy (especially improved cost-benefit-assessments) the article shows new approaches for an intensified prevention and health promotion. © Georg Thieme Verlag KG Stuttgart · New York.

  2. LBL Socio-Economic Environmental-Demographic Information System (SEEDIS). Chart: graphic analysis and display system

    Energy Technology Data Exchange (ETDEWEB)

    Sventek, V.A.

    1978-03-01

    The Chart Graphic Analysis and Display System was developed as part of Lawrence Berkeley Laboratory's Socio-Economic-Environmental-Demographic Information System (SEEDIS) to provide a tool with which users could draw graphs, print tables of numbers, do analysis, and perform basic statistical operations on the same set of data from a terminal in their own office. The Chart system's operation is completely independent of the type of data being entered and has been used for applications ranging from employment to energy data. Users frequently save the data they put into Chart and add to it on a regular basis, and thereby create personal databases which can be blended with information from the formal databases maintained at LBL. Using any computer system requires that the user learn a set of instructions, which at the onset often seems overwhelming. It is the purpose of this workbook to make this initial learning process less traumatic. The typical use of Chart is to enter a set of numbers, and then tell Chart what should be done with them. Chart commands take the form of gruff pidgin English. There are approximately 50 commands available. This workbook illustrates the basic commands. (RWR)

  3. Alternative health care consultations in Ontario, Canada: A geographic and socio-demographic analysis.

    Science.gov (United States)

    Williams, Allison M; Kitchen, Peter; Eby, Jeanette

    2011-06-22

    An important but understudied component of Canada's health system is alternative care. The objective of this paper is to examine the geographic and socio-demographic characteristics of alternative care consultation in Ontario, Canada's largest province. Data is drawn from the Canadian Community Health Survey (CCHS Cycle 3.1, 2005) for people aged 18 or over (n = 32,598) who had a consultation with an alternative health care provider. Four groups of consultations are examined: (1) all consultations (2) massage therapy (3) acupuncture, and (4) homeopath/naturopath. Descriptive statistics, mapping and logistic regression modeling are employed to analyze the data and to compare modalities of alternative health care use. In 2005, more than 1.2 million adults aged 18 or over consulted an alternative health care provider, representing about 13% of the total population of Ontario. The analysis revealed a varied geographic pattern of consultations across the province. Consultations were fairly even across the urban to rural continuum and rural residents were just as likely to consult a provider as their urban counterparts. From a health perspective, people with a chronic condition, lower health status and self-perceived unmet health care needs were more likely to see an alternative health provider. Women with chronic conditions such as fibromyalgia, high blood pressure, chronic fatigue syndrome and chemical sensitivities were more likely to see an alternative provider if they felt their health care needs were not being met. The analysis revealed that geography is not a factor in determining alternative health care consultations in Ontario. By contrast, there is a strong association between these consultations and socio-demographic characteristics particularly age, sex, education, health and self-perceived unmet health care needs. The results underscore the importance of women's health needs as related to alternative care use. The paper concludes that there is a need for

  4. An analysis of the socio-demographic characteristics of sole registered births and infant deaths.

    Science.gov (United States)

    Messer, Julie

    2011-01-01

    Differences in birth characteristics and infant mortality rates by marital status and birth registration type reflect complex underlying factors. In particular, births registered solely by the mother are seen as a disadvantaged group. This article analyses the socio-demographic characteristics of births by registration type and parents' marital status and explores these differences for health outcomes. Birth notifications data from the NHS Numbers for Babies system was linked to birth registration data held by the Office for National Statistics (ONS) for births occurring in 2007 and 2008 in England and Wales. This dataset was further linked to death registration data to identify infants who died before their first birthday.Regression analysis was used to compare factors and health outcomes across marital and registration status groups. Regression models were calculated to determine the main risk factors for poor outcomes. The registration groups differed in the age of the mother at birth, the proportion of young mothers, ethnic group distribution and measures of deprived circumstances. The joint registered-different address and sole registered groups were similar in the proportion of young mothers and the deprivation indices. The groups also differed in the proportion of low birthweight and premature babies. The joint registered-different address and sole registered groups both had higher percentages of 'small for gestational age' babies compared with the within-marriage and joint registered-same address groups. The stillbirth rate was highest in the sole registered group. Both the joint registered-different address and sole registered groups had higher infant mortality rates compared with the within-marriage and joint registered-same address groups. Multivariate analysis indicated that low birthweight was a key factor in infant mortality. Births registered solely by the mother were found to be a disadvantaged group but were also similar to the joint

  5. Alternative health care consultations in Ontario, Canada: A geographic and socio-demographic analysis

    Directory of Open Access Journals (Sweden)

    Eby Jeanette

    2011-06-01

    Full Text Available Abstract Background An important but understudied component of Canada's health system is alternative care. The objective of this paper is to examine the geographic and socio-demographic characteristics of alternative care consultation in Ontario, Canada's largest province. Methods Data is drawn from the Canadian Community Health Survey (CCHS Cycle 3.1, 2005 for people aged 18 or over (n = 32,598 who had a consultation with an alternative health care provider. Four groups of consultations are examined: (1 all consultations (2 massage therapy (3 acupuncture, and (4 homeopath/naturopath. Descriptive statistics, mapping and logistic regression modeling are employed to analyze the data and to compare modalities of alternative health care use. Results In 2005, more than 1.2 million adults aged 18 or over consulted an alternative health care provider, representing about 13% of the total population of Ontario. The analysis revealed a varied geographic pattern of consultations across the province. Consultations were fairly even across the urban to rural continuum and rural residents were just as likely to consult a provider as their urban counterparts. From a health perspective, people with a chronic condition, lower health status and self-perceived unmet health care needs were more likely to see an alternative health provider. Women with chronic conditions such as fibromyalgia, high blood pressure, chronic fatigue syndrome and chemical sensitivities were more likely to see an alternative provider if they felt their health care needs were not being met. Conclusions The analysis revealed that geography is not a factor in determining alternative health care consultations in Ontario. By contrast, there is a strong association between these consultations and socio-demographic characteristics particularly age, sex, education, health and self-perceived unmet health care needs. The results underscore the importance of women's health needs as related to

  6. WHAT SOCIO-DEMOGRAPHIC CHARACTERISTICS DO INFLUENCE THE LEVEL OF TOURIST’S SATISFACTION IN MONTENEGRO? EMPIRICAL ANALYSIS

    Directory of Open Access Journals (Sweden)

    Đurđica PEROVIĆ

    2012-12-01

    Full Text Available Montenegro as tourist destination is committed to providing a high quality experience for the tourists while carefully managing the use of a rare natural resource. In order to achieve the strategic objectives in sustainable tourism development in the future, the main focus should be given to the analysis of the main determinants of tourist satisfaction. Using a database that provides information on tourist travel behaviour and satisfaction during her/his stay in Montenegro, we have conducted empirical analysis to understand if the socio-demographic characteristics are associated with the level of tourist’s satisfaction. The effect of socio-demographic characteristics is measured through five dimensions: gender, age, country of residence, occupation and wage. Using multinomial logit model we analyze above mentioned socio-demographic characteristics and their influence on the level of tourist’s satisfaction in Montenegro.

  7. Use of county level data in health, energy, demographic, environmental, and economic analysis

    Energy Technology Data Exchange (ETDEWEB)

    Morris, S.C.; Novak, K.M.; Calef, C.E. (eds.)

    1979-04-01

    This document is an edited record of the conversation, dialogues, and topical discussions of the participants of a computer conference sponsored by the Biomedical and Environmental Assessment Division of Brookhaven National Laboratory during the period March 4-28, 1977. The main objective of the conference was to bring together a number of individual specialists from a wide and diverse range of both academic and professional disciplines to address the usage of county level data in health, energy, demographic, environmental, and economic analysis. A secondary aim of the conference was to test the feasibility and viability of using a computer conference as a means of accomplishing our primary objective. A preface, a list of participants, and the transcript of the main conference and subsession proceedings are included. Also included are information provided by participants on the identification of intercensal county equivalent areas and additional reports and documents relevant to the conference topic. The overall aims and objectives of the conference were successfully accomplished; some of the problems encountered using the computer as a conference vehicle were noted; recommendations were made to continue both formal and informal lines of communication on the subject of county level data.

  8. An Empirical Analysis of Socio-Demographic Stratification in Sweetened Carbonated Soft-Drink Purchasing

    OpenAIRE

    Rhodes, Charles

    2012-01-01

    Caloric soft drinks are the number one source of added sugars in U.S. diets, and are associated with many health problems. Three recent years of household purchase, household demographic, and industry advertising data allow Heckit estimation to identify how specific demographic groups vary in their purchase response to marketing of sweetened carbonated soft drinks (sCSDs) at the product category level. Empirical results reveal unique non-linear patterns of household purchase response to sCSD-...

  9. Analysis of real-time crash risk for expressway ramps using traffic, geometric, trip generation, and socio-demographic predictors.

    Science.gov (United States)

    Wang, Ling; Abdel-Aty, Mohamed; Lee, Jaeyoung; Shi, Qi

    2017-07-07

    There have been numerous studies on real-time crash prediction seeking to link real-time crash likelihood with traffic and environmental predictors. Nevertheless, none has explored the impact of socio-demographic and trip generation parameters on real-time crash risk. This study analyzed the real-time crash risk for expressway ramps using traffic, geometric, socio-demographic, and trip generation predictors. Two Bayesian logistic regression models were utilized to identify crash precursors and their impact on ramp crash risk. Meanwhile, four Support Vector Machines (SVM) were applied to predict crash occurrence. Bayesian logistic regression models and SVMs commonly showed that the models with the socio-demographic and trip generation variables outperform their counterparts without those parameters. It indicates that the socio-demographic and trip generation parameters have significant impact on the real-time crash risk. The Bayesian logistic regression model results showed that the logarithm of vehicle count, speed, and percentage of home-based-work production had positive impact on crash risk. Meanwhile, off-ramps or non-diamond-ramps experienced higher crash potential than on-ramps or diamond-ramps, respectively. Though the SVMs provided good model performance, the SVM model with all variables (i.e., all traffic, geometric, socio-demographic, and trip generation variables) had an overfitting problem. Therefore, it is recommended to build SVM models based on significant variables identified by other models, such as logistic regression. Copyright © 2017 Elsevier Ltd. All rights reserved.

  10. The households of Serbia at the dawn of third millennium: Socio-demographical analysis

    Directory of Open Access Journals (Sweden)

    Bobić Mirjana

    2004-01-01

    Full Text Available Side by side with tumultuous social processes in the end of XXth century great demographical changes have been taking place in Serbia, such as: the decline of nuptiality and fertility, postponement of family formation into older ages of life course of individuals, the rise of: extramarital births as well as adolescent pregnancies and live births, the spread of one-parent households, particularly of lone mothers, and divorces. Besides that, the main feature of the demographic development of Serbia has been increased mobility of population, namely migrations of highly educated professionals to the West ("brain drain" and forced migration of refugees and internally displaced persons to Serbia, as a consequence of armed conflicts in its surroundings and at Kosovo and Metohija. All the above-mentioned demographical changes caused the precomposition of households, as profound associations of population, where its biological and socio-economical reproductions take place. The information of last census of population of Serbia in 2002 indicate that according to the features of family and households, Serbia has approached the countries of Central and Eastern Europe, that are forerunning in the process of post-socialistic transformation and European integrations. Common characteristics of all those countries are: decrease of universality and popularity of marriage delay of childbearing, continuation of earlier demographic tendencies: of low natality, depopulation and aging of population. All those processes have contributed to the transformation of prevailing forms of households, i.e. decline of nuclear family units and the rise of single person households households of aged persons, as well as single-parent ones. As to the Serbia the demographic differences between its separate parts: Vojvodina and central Serbia, have been fading for the first time in its history, owing to previous socio-demographic developments starting from the beginning of XXth

  11. Confidence in Government and Attitudes toward Bribery: A Country-Cluster Analysis of Demographic and Religiosity Perspectives

    Directory of Open Access Journals (Sweden)

    Serkan Benk

    2017-01-01

    Full Text Available In this study, we try to classify the countries by the levels of confidence in government and attitudes toward accepting bribery by using the data of the sixth wave (2010–2014 of the World Values Survey (WVS. We are also interested in which demographic, attitudinal, and religiosity variables affect each class of countries. For these purposes cluster analysis, linear regression analysis, and ordered logistic regression analysis were used. The study found that countries could be grouped into two clusters which had varying levels of opposition to bribe taking and confidence in government. Another finding was that certain demographic, attitudinal, and religiosity variables that were significant in one cluster might not be significant in another cluster.

  12. Population and development in Asia and the Pacific: a demographic analysis.

    Science.gov (United States)

    Debavalya, N

    1982-06-01

    Close examinations of population trends shows that the new trends reflect demographic changes that have occurred in many developing countries in Asia and the Pacific. In East Asia the population growth rate has declined rather rapidly from 1.94% in 1960-65 to 1.38% in 1975-80 and 1.24% in 1980-85. Since nearly 85% of this region's population is accounted for by China, demographic trends there virtually dictate the trends for the region as a whole. The available data suggest that the growth rate in China declined from 2.02% in 1970-75 to 1.4% in 1975-80 and is expected to reach 1.27% during 1980-85. The sharp decline in China's population growth rate is expected to continue. It is anticipated that the population of East Asia will increase to 1.4 billion by the year 2000. In addition, the growth rate has declined significantly in Japan and the Republic of Korea. The growth rate is declining in Eastern South and Middle South Asia as well. Longterm declines have brought growth rates down in Sri Lanka and Singapore. More recently, the rate of growth also has begun to fall in India, Indonesia, Malaysia, the Philippines, and Thailand, while it remains generally at high levels in Bangladesh, Nepal, and Pakistan. In the Oceania region, 79% of which is made up of Australia and New Zealand, the growth rate is also steadily decreasing. Despite the decrease in the growth rate of Asia and the Pacific, especially during 1980-2000, in absolute terms its growth will be the largest in the world during these 29 years; 908 million out of 1687 million of the total growth. Asia and the Pacific will contribute more than 45 million people a year during the final 20 years of this century. For the world as a whole, the new estimates and projections indicate a slow but steady decline of the crude birthrate from 36.3/1000 in 1950-55 to 28.5 in 1975-80, then to 23.9 in 1995-2000, and finally to 17.9 in 2020-2025. China had a birthrate estimated at about 21 in 1975-80; and India and Indonesia

  13. Monitoring Socio-Demographic Risk: A Cohort Analysis of Families Using Census Micro-Data

    Science.gov (United States)

    Davis, Peter; McPherson, Mervyl; Wheldon, Mark; von Randow, Martin

    2012-01-01

    We apply cohort techniques to monitor four indicators of socio-demographic risk crucial to family wellbeing; namely, income, employment, education, and housing. The data were derived from New Zealand's five-yearly Census for the period 1981-2006. This allowed us to track birth cohorts of mothers (and their families) over six successive New Zealand…

  14. Distribution of Health-Related Physical Fitness in Texas Youth: A Demographic and Geographic Analysis

    Science.gov (United States)

    Welk, Gregory J.; Meredith, Marilu D.; Ihmels, Michelle; Seeger, Chris

    2010-01-01

    This study examined demographic and geographic variability in aggregated school-level data on the percentage of students achieving the FITNESSGRAM[R] Healthy Fitness Zones[TM] (HFZ). Three-way analyses of variance were used to examine differences in fitness achievement rates among schools that had distinct diversity and socioeconomic status…

  15. Demographic-Based Content Analysis of Web-Based Health-Related Social Media

    Science.gov (United States)

    Shahbazi, Moloud; Wiley, Matthew T; Hristidis, Vagelis

    2016-01-01

    Background An increasing number of patients from diverse demographic groups share and search for health-related information on Web-based social media. However, little is known about the content of the posted information with respect to the users’ demographics. Objective The aims of this study were to analyze the content of Web-based health-related social media based on users’ demographics to identify which health topics are discussed in which social media by which demographic groups and to help guide educational and research activities. Methods We analyze 3 different types of health-related social media: (1) general Web-based social networks Twitter and Google+; (2) drug review websites; and (3) health Web forums, with a total of about 6 million users and 20 million posts. We analyzed the content of these posts based on the demographic group of their authors, in terms of sentiment and emotion, top distinctive terms, and top medical concepts. Results The results of this study are: (1) Pregnancy is the dominant topic for female users in drug review websites and health Web forums, whereas for male users, it is cardiac problems, HIV, and back pain, but this is not the case for Twitter; (2) younger users (0-17 years) mainly talk about attention-deficit hyperactivity disorder (ADHD) and depression-related drugs, users aged 35-44 years discuss about multiple sclerosis (MS) drugs, and middle-aged users (45-64 years) talk about alcohol and smoking; (3) users from the Northeast United States talk about physical disorders, whereas users from the West United States talk about mental disorders and addictive behaviors; (4) Users with higher writing level express less anger in their posts. Conclusion We studied the popular topics and the sentiment based on users' demographics in Web-based health-related social media. Our results provide valuable information, which can help create targeted and effective educational campaigns and guide experts to reach the right users on Web

  16. Demographic estimates from Y chromosome microsatellite polymorphisms: Analysis of a worldwide sample

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    Macpherson J

    2004-08-01

    Full Text Available Abstract Polymorphisms in microsatellites on the human Y chromosome have been used to estimate important demographic parameters of human history. We compare two coalescent-based statistical methods that give estimates for a number of demographic parameters using the seven Y chromosome polymorphisms in the HGDP-CEPH Cell Line Panel, a collection of samples from 52 worldwide populations. The estimates for the time to the most recent common ancestor vary according to the method used and the assumptions about the prior distributions of model parameters, but are generally consistent with other global Y chromosome studies. We explore the sensitivity of these results to assumptions about the prior distributions and the evolutionary models themselves.

  17. Population and development in Asia and the Pacific: a demographic analysis.

    Science.gov (United States)

    Debavalya, N

    1983-01-01

    The proportion of the world population in the less developed regions, in contrast to the more developed countries, has been steadily growing from 67% of the world total in 1950 to 74% in 1980, and it is expected to reach 79% by the end of the century. It is also projected that by the year 2025the less developed regions will include 83% of the world population total. Close examination of population trends shows that the new trends reflect demographic changes that have taken place in many developing nations in Asia and the Pacific. Despite reduction in the growth rate of Asia andthe Pacific, especially during 1980-2000, in absolute terms its growth will be the largest in the world during these 20 years, 908 million out of 1687 million of the total growth. Asia and the Pacific will contribute more than 45 million people a year during the final 20 years of this century. For the world as a whole, the new estimates and projections indicate a slow but steady decline of the crude birthrate from 36.3/1000 in 1959-55 to 28.5 in 1975-80, then to 23.9 in 1955-2000, and finally to 17.9 in 2020-2025. Since 1950 it is estimated that the gross reproduction rate increased, reached its peak of 2.21 in 1970-75 and has been steadily declining. Japan, Australia, and New Zealand, the developed countries in Asia and the Pacific, have estimated birthrates in the range of 15-18 in 1975-80. In contrast with the high levels which prevail in Western and MiddleSouth Asia, fertility declines of considerable magnitude have been realized in some countries in East Asia and South Asia. As was the case with fertility, the largest gains in mortality reduction have accured among the less developed regions. A widespread, though not universal, feature of recent mortality trends appears to be a recent slowdown in progress, which, in some places, is manifested by a cessation in mortality decline. Data for Asia also indicate that mortality declines have slowed during recent years. International migration

  18. Study of Some Demographic Properties Influencing the Burnout Levels of Nurses in Public Hospitals by CHAID Analysis

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    Zübeyir BAĞCI

    2015-12-01

    Full Text Available In this study, it is aimed to identify the burnout levels of nurses which prevent them from doing their business more efficiently and to examine the effects of various demographic variables on burnout. The data necessary for the research have been gathered from 256 nurses working in public hospitals within borders of central district of Denizli province using “Maslach Burnout Inventory”. They were analyzed by SPSS and CHAID was used as the analysis method. In consequence it has been determined that nurses experience low-level emotional exhaustion, average-level depersonalization and high-level decrease in personal accomplishment. It has also been concluded that burnout levels are affected by demographic properties such as age, marital status, tenure of office, daily workload, education and income level

  19. Vape Shop Density and Socio-demographic Disparities: A U.S. Census Tract Analysis.

    Science.gov (United States)

    Dai, Hongying; Hao, Jianqiang; Catley, Delwyn

    2017-03-20

    Vape shops are an emerging business specializing in the sales and promotion of e-cigarette, e-juice and other vaping products. This study sought to evaluate the associations between vape shop density and socio-demographic characteristics at the U.S. census tract level. Vape shop data (n=9,943) were collected from three online directories: Yelp.com, Yellowpages.com, and Guidetovaping.com. Addresses of vape shops were geocoded and the density per 10,000 people was estimated at each U.S. census tract. Zero inflated negative binomial regression model was performed to examine the socio-demographic factors associated with vape shop density. Overall, there was a higher vape shop density in urban versus non-urban census tracts. In urban areas, higher vape shop density was associated with larger proportions of Hispanics and Asians, adults aged 18-44 years old and higher poverty, while the decrease in vape shop density was associated with larger proportions of population under 18 years old, higher education, larger household size, and a higher percentage of owner occupied housing units. In non-urban areas, higher vape shop density was associated larger proportions of African Americans and Hispanics, smaller household size and a lower percentage of owner occupied housing units. At the national level, there are inequalities of vape shop density by some socio-demographic characteristics and heterogeneity between urban and non-urban areas. Vape shops are more likely to be concentrated in areas where people with a higher risk for vaping and smoking reside. Our findings could inform initiatives aimed at a stronger licensing requirement for vape shops and federal and state-level regulations of this industry to prevent vape shop from targeting minority and other socially disadvantaged groups.

  20. Segmentation analysis of financial savings markets through the lens of psycho-demographics

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    Tendy Matenge

    2016-03-01

    Full Text Available Purpose: This study seeks to contribute to the discourse of financial savings market segmentation. The study explores different segments of savers on the basis of demographic and psychographic characteristics that are unique to each segment relying on the perspectives of a sample of consumers of financial saving programmes. Design/methodology/approach: Principles of perceptual mapping were used to analyse 33 semi-structured interviews that gathered data on the participants’ psychographic make-up such as personal values, motives for saving, attitudes towards savings and perceived conditions of savings. Findings: Eight distinct segments emerged on each psychographic characteristic based on the participants’ demographics of income, gender and age. However, only five were sizeable enough to be interpreted, being three segments from the males’ category and two from the females’ category. The three segments that emerged within the male category are young low-income earners (YoLI, young high-income earners (YoHI and old high-income earners (OHI while the two female segments include YoLI and OHI. The most sizeable segment of savers in both gender-based categories is one of old adults who have a high income. These segments vary in terms of values, motives and perceptions. Originality/value: The study suggests that a multi-dimensional approach of segmenting financial savings markets is more effective, as neither the demographic nor the psychographic segmentation can fully describe the saving behaviour of consumers. Research implications: The findings of the present study provide strategic communication implications for financial institutions for the respective segments.

  1. Structured Modeling and Analysis of Stochastic Epidemics with Immigration and Demographic Effects.

    Science.gov (United States)

    Baumann, Hendrik; Sandmann, Werner

    2016-01-01

    Stochastic epidemics with open populations of variable population sizes are considered where due to immigration and demographic effects the epidemic does not eventually die out forever. The underlying stochastic processes are ergodic multi-dimensional continuous-time Markov chains that possess unique equilibrium probability distributions. Modeling these epidemics as level-dependent quasi-birth-and-death processes enables efficient computations of the equilibrium distributions by matrix-analytic methods. Numerical examples for specific parameter sets are provided, which demonstrates that this approach is particularly well-suited for studying the impact of varying rates for immigration, births, deaths, infection, recovery from infection, and loss of immunity.

  2. ANALYSIS OF PUBLIC SCHOOL TEACHERS’ PERSONALITY TRAITS ACCORDING TO DEMOGRAPHIC VARIABLES

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    Nurhayat ÇELEBİ

    2014-06-01

    Full Text Available The aim of this study is to demonstrate the relations and differences between personality traits of teachers and some demographic variables. This research is designed in a descriptive survey model. The study group is composed of 407 teachers who are working in 22 public high schools from Ataşehir, Beşiktaş, Güngören and Ümraniye districts of Istanbul. Big Five Inventory, which is developed by Benet-Martinez and John (1998 and adapted to Turkish by Sümer and Sümer (2005, is used in order to assess the teacher personality traits. The scale of Alpha coefficient is, .699. As a result, teachers the highest average is in openness to experience and the lowest average is in neuroticism. Also it is found that significant differences exist between teachers’ personality traits and demographic variables. In accordance to this, significant differences are observed between gender variable and conscientiousness, extraversion, agreeableness, neuroticism. There are similar differences between marital status variable and openness to experience, conscientiousness, agreeableness. The differences between branch variable and openness to experience, extraversion are also significant.

  3. The treatment and demographics of warts: an analysis of national trends.

    Science.gov (United States)

    Reeder, Virginia J; Gustafson, Cheryl J; Davis, Scott A; Fleischer, Alan B; Huang, William W

    2013-12-01

    Verrucae (warts) are a very common dermatologic disease. They can be of cosmetic concern, cause physical discomfort, and predispose patients to certain malignancies. Management of warts has traditionally been based on anatomic location, clinical appearance, and patient preference. To investigate trends in the treatment of warts, as well as patient demographics associated with the diagnosis of warts. The National Ambulatory Medical Care Survey (NAMCS) was queried for data regarding patient visits associated with the diagnosis of warts from 1990 to 2009. There was a significant increase in the use of topical imiquimod during the study period, such that it became the most frequently used medication for warts. No statistically significant trends were detected regarding the frequency of treatment with medication only, procedure only, or combination treatment. In terms of patient demographics, there was an upward trend in regards to increasing patient age and the diagnosis of warts. However, there were no significant trends with respect to patient gender or race and the diagnosis of warts. Warts not otherwise specified (NOS) was the reported diagnosis for more than eighty percent of patient visits for warts. Trends in the treatment of plantar warts could not be evaluated as the ICD-9 code designating this diagnosis was recently instituted in 2009. Data from NAMCS are cross-sectional in nature. The advent of a new therapy and shifts in population patterns have modified the epidemiologic profile and treatment of warts.

  4. Application of agriculture-developed demographic analysis for the conservation of the Hawaiian alpine wekiu bug.

    Science.gov (United States)

    Eiben, Jesse; Rubinoff, Daniel

    2014-08-01

    Insects that should be considered for conservation attention are often overlooked because of a lack of data. The detailed information necessary to assess population growth, decline, and maximum range is particularly difficult to acquire for rare and cryptic species. Many of these difficulties can be overcome with the use of life table analyses and heat energy accumulation models common in agriculture. The wekiu bug (Nysius wekiuicola), endemic to the summit of one volcanic mountain in Hawaii, is a rare insect living in an environmentally sensitive alpine stone desert, where field-based population assessments would be inefficient or potentially detrimental to natural and cultural resources. We conducted laboratory experiments with the insects by manipulating rearing temperatures of laboratory colonies and made detailed observations of habitat conditions to develop life tables representing population growth parameters and environmental models for wekiu bug phenology and demographic change. Wekiu bugs developed at temperatures only found in its environment on sunny days and required the thermal buffer found on cinder cones for growth and population increase. Wekiu bugs required approximately 3.5 months to complete one generation. The bug developed optimally from 26 to 30 °C, temperatures that are much higher than the air temperature attains in its elevational range. The developmental temperature range of the species confirmed a physiological reason why the wekiu bug is only found on cinder cones. This physiology information can help guide population monitoring and inform habitat restoration and conservation. The wekiu bug was a candidate for listing under the U.S. Endangered Species Act, and the developmental parameters we quantified were used to determine the species would not be listed as endangered or threatened. The use of developmental threshold experiments, life table analyses, and degree day modeling can directly inform otherwise unobservable habitat needs and

  5. Demographic monitoring and population viability analysis of two rare beardtongues from the Uinta Basin

    Science.gov (United States)

    McCaffery, Rebecca M.; Reisor, Rita; Irvine, Kathryn M.; Brunson, Jessi

    2014-01-01

    Energy development, in combination with other environmental stressors, poses a persistent threat to rare species endemic to the energy-producing regions of the Western United States. Demographic analyses of monitored populations can provide key information on the natural dynamics of threatened plant and animal populations, and how they might be affected by ongoing and future development. In the Uinta Basin in Utah and Colorado, Graham’s beardtongue (Penstemon grahamii) and White River beardtongue (Penstemon scariosus var. albifluvis) are two rare endemic wildflowers that persist on oil shale habitats heavily impacted by current energy exploration and development, and slated for expanded traditional drilling and oil shale development. We described demographic characteristics and population viability for two populations of each species that have been monitored since 2004. First, we measured population size, survival rates, transitions between life stages, and recruitment using individually marked plants at the four study areas. Then, we used matrix population models to determine stochastic population growth rates (λ) and the probability that each population would persist 50 years into the future, given current conditions. The two P. grahamii study plots had small populations averaging 70 adult plants, and relatively constant and high survival in both vegetative and flowering plants. The two P. scariosus var. albifluvis study plots had populations that averaged 120 adult plants, with high and stable survival in flowering plants and variable survival in vegetative plants. Recruitment of new seedlings into all populations was low and variable, with most recruitment occurring in one or two years. Both P. grahamii populations had λ near 1.0 (stable). One P. scariosus var. albifluvis population appeared to be declining (λ=0.97), while the other was increasing (λ=1.16). Our analyses reveal populations that appear relatively stable, but that are

  6. demogR: A Package for the Construction and Analysis of Age-structured Demographic Models in R

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    James Holland Jones

    2007-08-01

    Full Text Available The analysis of matrix population models has become a fundamental tool in ecology, conservation biology, and life history theory. In this paper, I present demogR, a package for analyzing age-structured population models in R. The package includes tools for the construction and analysis of matrix population models. In addition to the standard analyses commonly used in evolutionary demography and conservation biology, demogR contains a variety of tools from classical demography. This includes the construction of period life tables, and the generation of model mortality and fertility schedules for human populations. The tools in demogR are generally applicable to age-structured populations but are particularly useful for analyzing problems in human ecology. I illustrate some of the capabilities of the package by doing an evolutionary demographic analysis of several human populations.

  7. [Emigration from Burkina Faso from 1960 to 1985. Analysis of demographic and socioeconomic consequences].

    Science.gov (United States)

    Some, P

    1991-04-01

    Labor migration from Burkina Faso did not end when direct recruitment of workers by planters from the Ivory Coast was terminated at independence in 1960. Methodological problems and differences in the objectives of the 1975 and 1985 censuses and the 1960-61 sample survey have limited the usefulness of existing data on migration. Migrants from Burkina Faso have always been unskilled workers in search of wage employment. The migrant population in 1960-61 was estimated at 152,442, of whom 90% were males primarily under 40 years old. The proportion of women and children increased from 8.2% in 1961 to 12.8% in 1973. Between the 1975 and 1985 censuses, there were few significant changes in the dominant characteristics of migrants. 80% of the 808,000 residents living abroad according to official sources were male and 80% were aged 15-40 years. 53% of migrants according to a 1975 study were under 20 years old at the 1st departure, and most were single. At the national level, labor migration is viewed as a necessary evil that should continue as long as possible in the absence of employment opportunities at home. After independence in 1960, 56.6% of migrants from Burkina Faso went to the Ivory Coast, 31.3% to Ghana, and 3.9% to Mali. In 1975 and 1985 respectively, 74.4% and 91.2% went to the Ivory Coast and 11.8% and 8.8% to Ghana. The demographic consequences of migration in Burkina Faso include a lowering of the natural increase rate and a reduction of the economically active population amounting to about 16% between 1975-85. The disproportionate departure of men has left an increasing number of women in charge of agricultural operations. A strong current of return migration has also developed, including many children under 15. It was estimated in 1990 that half of migrants to the Ivory Coast receive professional training, with the other half exposed to new agricultural techniques and methods of organizing work. 87% of returning male migrants in 1985 went back to their

  8. Statistical Analysis of Demographic and Temporal Differences in LANL's 2014 Voluntary Protection Program Survey

    Energy Technology Data Exchange (ETDEWEB)

    Davis, Adam Christopher [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Booth, Steven Richard [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-08-20

    Voluntary Protection Program (VPP) surveys were conducted in 2013 and 2014 to assess the degree to which workers at Los Alamos National Laboratory feel that their safety is valued by their management and peers. The goal of this analysis is to determine whether the difference between the VPP survey scores in 2013 and 2014 is significant, and to present the data in a way such that it can help identify either positive changes or potential opportunities for improvement. Data for several questions intended to identify the demographic groups of the respondent are included in both the 2013 and 2014 VPP survey results. These can be used to identify any significant differences among groups of employees as well as to identify any temporal trends in these cohorts.

  9. The economics of counterfeit Avastin: a geospatial and statistical analysis of demographic correlates to FDA warning letters.

    Science.gov (United States)

    Cuomo, Raphael E; Mackey, Tim K; Stigler, Paula

    2015-07-01

    In 2012, the Food and Drug Administration (FDA) sent warning notices to clinics and medical practitioners that may have purchased or administered counterfeited versions of the angiogenesis cancer drug Avastin Genentech, South San Francisco, California, USA. The purpose of this study was to explore potential differences in demographic, economic, and healthcare coverage characteristics between areas that received these counterfeit warning notices and those that did not receive notices. The aims of this study are to improve future counterfeit drug surveillance and better assess potential risk factors associated with counterfeit cancer drugs. Addresses for warning notices sent to healthcare practitioners were obtained from the FDA and then geocoded using arcgis. Variables chosen for statistical and geospatial analyses were then identified and assessed based on their potential association with Avastin access and affordability. These variables included demographic and economic factors (percent below the poverty line, percent uninsured, and median household income) and healthcare coverage data (percent Medicare enrollees) available from the US Center for Medicare and Medicaid Services. All variables were analyzed at the US county level. Our analysis uncovered 401 distinct US counties where the FDA sent at least one counterfeit Avastin warning notice. A hot spot analysis of notices and variables was carried out using arcgis software to identify and visualize risk features with high and low values of clustering. In a multiple logistic regression model reassessing visually observed geospatial associations, the receipt of a notice was not significantly associated with percent uninsured (p = 0.3121), but was significantly associated with percent Medicare enrollees (OR = 0.874 per 10% increase; p = 0.0121), individuals below federal poverty line (OR = 2.990 per 10% increase; p economic and demographic factors are potentially associated with counterfeit Avastin

  10. A Bottom-up Vulnerability Analysis of Water Systems with Decentralized Decision Making and Demographic Shifts- the Case of Jordan.

    Science.gov (United States)

    Lachaut, T.; Yoon, J.; Klassert, C. J. A.; Talozi, S.; Mustafa, D.; Knox, S.; Selby, P. D.; Haddad, Y.; Gorelick, S.; Tilmant, A.

    2016-12-01

    Probabilistic approaches to uncertainty in water systems management can face challenges of several types: non stationary climate, sudden shocks such as conflict-driven migrations, or the internal complexity and dynamics of large systems. There has been a rising trend in the development of bottom-up methods that place focus on the decision side instead of probability distributions and climate scenarios. These approaches are based on defining acceptability thresholds for the decision makers and considering the entire range of possibilities over which such thresholds are crossed. We aim at improving the knowledge on the applicability and relevance of this approach by enlarging its scope beyond climate uncertainty and single decision makers; thus including demographic shifts, internal system dynamics, and multiple stakeholders at different scales. This vulnerability analysis is part of the Jordan Water Project and makes use of an ambitious multi-agent model developed by its teams with the extensive cooperation of the Ministry of Water and Irrigation of Jordan. The case of Jordan is a relevant example for migration spikes, rapid social changes, resource depletion and climate change impacts. The multi-agent modeling framework used provides a consistent structure to assess the vulnerability of complex water resources systems with distributed acceptability thresholds and stakeholder interaction. A proof of concept and preliminary results are presented for a non-probabilistic vulnerability analysis that involves different types of stakeholders, uncertainties other than climatic and the integration of threshold-based indicators. For each stakeholder (agent) a vulnerability matrix is constructed over a multi-dimensional domain, which includes various hydrologic and/or demographic variables.

  11. Analysis of factors associated with patient satisfaction in ophthalmology: the influence of demographic data, visit characteristics and perceptions of received care.

    Science.gov (United States)

    Schoenfelder, Tonio; Klewer, Joerg; Kugler, Joachim

    2011-11-01

    To identify factors associated with satisfaction among patients receiving ophthalmic services and to indicate the intensity of this relationship. The data used was obtained through a self-administered, post-visit questionnaire from randomly selected 507 patients treated in seven eye clinics in Germany. The instrument assessed satisfaction with several aspects of care and patient baseline and visit characteristics. Bivariate and multivariate techniques were used to reveal relations between indicators and overall satisfaction. Factor analysis yielded two factors, 'medical aspects of care' and 'performance of service', explaining 55% of total variance. Cronbach's α coefficient for both scales indicates acceptable internal consistency. Bivariate analysis showed strong relations between overall satisfaction and perceived care with weaker findings pertaining to visit characteristics. Not any of the demographic variables was associated with overall satisfaction. Perceived length of stay, intention to return to the clinic, and occurrence of complications were influential attributes on satisfaction ratings. The multivariate analysis identified seven factors associated with overall satisfaction including the treatment outcome (OR: 4.57), kindness of the nurses (OR: 5.27) and medical practitioners (OR: 2.23), room amenities (OR: 2.72), organization of procedures and operations (OR: 2.71), information about anaesthesia (OR: 1.95), and cleanliness (OR: 1.93). Factors associated with patient satisfaction in ophthalmology concern medical aspects like the organization of procedures and operations but also aspects that are not directly related to technical care, such as kindness of the nurses and cleanliness. Results show that patients' subjective experiences of received care and services relate more strongly and consistently to overall satisfaction than patient demographic data or visit characteristics. Revealed factors predicting patient satisfaction are alterable by health care

  12. Demographic changes and nationalism.

    Science.gov (United States)

    Vishnevskii, A G

    1995-01-01

    This article examines the different characteristics of the many peoples inhabiting what used to be the Soviet Union and communist Eastern Europe, including Yugoslavia. The differences among these nationalities, or ethnic groups, are illustrated using the example of demographic modernization, showing how different peoples have or have not passed through the demographic transition process. The author looks at ethnic differences in mortality, fertility, natural increase, and migration, as well as economic and social inequalities among ethnic groups. The prospects for inter-ethnic conflict are assessed.

  13. Demographic Trends: Impact on Schools

    Science.gov (United States)

    Chong, Sylvia N. Y.; Cheah, Horn Mun

    2010-01-01

    Background: Singapore is experiencing great demographic change. These demographic trends show fewer young people and declining birth rates, greater longevity for ageing generations and an increase in the number of non-Singaporean residents. Statistics also show that more than half of the total population increase in the last decades was…

  14. Demographic and Socio-economic Determinants of Birth Interval Dynamics in Manipur: A Survival Analysis

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    Sanajaoba Singh N,

    2011-01-01

    Full Text Available The birth interval is a major determinant of levels of fertility in high fertility populations. A house-to-house survey of 1225 women in Manipur, a tiny state in North Eastern India was carried out to investigate birth interval patterns and its determinants. Using survival analysis, among the nine explanatory variables of interest, only three factors – infant mortality, Lactation and use of contraceptive devices have highly significant effect (P<0.01 on the duration of birth interval and only three factors – age at marriage of wife, parity and sex of child are found to be significant (P<0.05 on the duration variable.

  15. Determinants of childhood stunting in the Democratic Republic of Congo: further analysis of Demographic and Health Survey 2013-14.

    Science.gov (United States)

    Kismul, Hallgeir; Acharya, Pawan; Mapatano, Mala Ali; Hatløy, Anne

    2017-08-01

    Prevalence of child stunting in the Democratic Republic of Congo (DRC) is among the highest in the world. There is a need to systematically investigate how stunting operates at different levels of determination and identify major factors contributing to the development of stunting. The aim of this study was to look for key determinants of stunting in the DRC. This study used data from the DRC Demographic Health Survey 2013-14 which included anthropometric measurement for 9030 under 5 year children. Height-for-Age Z score was calculated and classified according to the WHO guideline. The association between stunting and bio-demographic characteristics was assessed using logistic regression. Prevalence of stunting was much higher in boys than girls. There was a significant rural urban gap in the prevalence of stunting with rural areas having a larger proportion of children living with stunting than urban. Male children, older than 6 months, preceding birth interval less than 24 months, being from lower wealth quintiles had the highest odds of stunting. Several provinces had in particular high odds of stunting. Early initiation of breastfeeding, mother's age more than 20 years at the time of delivery had lower odds of stunting. The taller the mother the less likely the child was to be stunted. Similarly, mother's BMI, access to safe water, access to hygienic toilet, mother's education were found negatively correlated with child stunting in the bivariate logistic regression, but they lost statistical significance in multivariate analysis together with numbers of children in the family and place of residence. Child stunting is widespread in the DRC and increasing prevalence is worrisome. This study has identified modifiable factors determining high prevalence of stunting in the DRC. Policy implementation should in particular target provinces with high prevalence of stunting and address modifiable determinants such as reducing socioeconomic disparity. Nutrition

  16. Analysis of Binary Multivariate Longitudinal Data via 2-Dimensional Orbits: An Application to the Agincourt Health and Socio-Demographic Surveillance System in South Africa.

    Directory of Open Access Journals (Sweden)

    Maria Vivien Visaya

    Full Text Available We analyse demographic longitudinal survey data of South African (SA and Mozambican (MOZ rural households from the Agincourt Health and Socio-Demographic Surveillance System in South Africa. In particular, we determine whether absolute poverty status (APS is associated with selected household variables pertaining to socio-economic determination, namely household head age, household size, cumulative death, adults to minor ratio, and influx. For comparative purposes, households are classified according to household head nationality (SA or MOZ and APS (rich or poor. The longitudinal data of each of the four subpopulations (SA rich, SA poor, MOZ rich, and MOZ poor is a five-dimensional space defined by binary variables (questions, subjects, and time. We use the orbit method to represent binary multivariate longitudinal data (BMLD of each household as a two-dimensional orbit and to visualise dynamics and behaviour of the population. At each time step, a point (x, y from the orbit of a household corresponds to the observation of the household, where x is a binary sequence of responses and y is an ordering of variables. The ordering of variables is dynamically rearranged such that clusters and holes associated to least and frequently changing variables in the state space respectively, are exposed. Analysis of orbits reveals information of change at both individual- and population-level, change patterns in the data, capacity of states in the state space, and density of state transitions in the orbits. Analysis of household orbits of the four subpopulations show association between (i households headed by older adults and rich households, (ii large household size and poor households, and (iii households with more minors than adults and poor households. Our results are compared to other methods of BMLD analysis.

  17. Analysis of Binary Multivariate Longitudinal Data via 2-Dimensional Orbits: An Application to the Agincourt Health and Socio-Demographic Surveillance System in South Africa.

    Science.gov (United States)

    Visaya, Maria Vivien; Sherwell, David; Sartorius, Benn; Cromieres, Fabien

    2014-01-01

    We analyse demographic longitudinal survey data of South African (SA) and Mozambican (MOZ) rural households from the Agincourt Health and Socio-Demographic Surveillance System in South Africa. In particular, we determine whether absolute poverty status (APS) is associated with selected household variables pertaining to socio-economic determination, namely household head age, household size, cumulative death, adults to minor ratio, and influx. For comparative purposes, households are classified according to household head nationality (SA or MOZ) and APS (rich or poor). The longitudinal data of each of the four subpopulations (SA rich, SA poor, MOZ rich, and MOZ poor) is a five-dimensional space defined by binary variables (questions), subjects, and time. We use the orbit method to represent binary multivariate longitudinal data (BMLD) of each household as a two-dimensional orbit and to visualise dynamics and behaviour of the population. At each time step, a point (x, y) from the orbit of a household corresponds to the observation of the household, where x is a binary sequence of responses and y is an ordering of variables. The ordering of variables is dynamically rearranged such that clusters and holes associated to least and frequently changing variables in the state space respectively, are exposed. Analysis of orbits reveals information of change at both individual- and population-level, change patterns in the data, capacity of states in the state space, and density of state transitions in the orbits. Analysis of household orbits of the four subpopulations show association between (i) households headed by older adults and rich households, (ii) large household size and poor households, and (iii) households with more minors than adults and poor households. Our results are compared to other methods of BMLD analysis.

  18. Demographic characteristic and analysis of pulmonary paragonimiasis in patients attending RIMS, Manipur

    Science.gov (United States)

    Sunanda, Haorongbam; Shivalingaiah, Bhavya; Paley, Tamar; Asoka, Wangkheimayum

    2016-01-01

    Background: Human infection by the lung fluke Paragonimus westermani is widely distributed in Africa, Asia, and South America. Transmission of the parasite to humans primarily occurs through the consumption of raw or undercooked crabs. Clinical features of recently diagnosed pulmonary Paragonimiasis show that patients present with a variety of clinical and radiological findings, frequently mimics tuberculosis and lung cancer. Methods: Here in this study, we report a cross-sectional study of pulmonary paragonimiasis in our institute over a period of two year. Results: it was observed that out of eleven cases, prevalence of paragonimiasis was almost equal among both the genders, with a mean age of 38.1 ± 16.96, affecting people from hills. Three patients were erroneously treated with antitubercular drugs without any relief. The association with eosinophilia in the peripheral blood and tissue[16] was seen in all the study subjects and majority patients had pleural fluid eosinophilia. Patients were diagnosed by serological test, Paragonimus ova in Sputum smear and Pleural fluid. All study subjects had excellent clinical responses to praziquantel given at dose of 25 mg/kg given orally 3 times daily for 3 consecutive days. Conclusions: There is a need to generate awareness among the clinicians and public regarding Paragonimiasis and to consider it in differential diagnosis of TB and carcinoma lung. Physicians should consider the possibility of paragonimiasis among patients who present with chest complaints with eosinophilia from the endemic regions. PMID:27051099

  19. Demographic characteristic and analysis of pulmonary paragonimiasis in patients attending RIMS, Manipur

    Directory of Open Access Journals (Sweden)

    Haorongbam Sunanda

    2016-01-01

    Full Text Available Background: Human infection by the lung fluke Paragonimus westermani is widely distributed in Africa, Asia, and South America. Transmission of the parasite to humans primarily occurs through the consumption of raw or undercooked crabs. Clinical features of recently diagnosed pulmonary Paragonimiasis show that patients present with a variety of clinical and radiological findings, frequently mimics tuberculosis and lung cancer. Methods: Here in this study, we report a cross-sectional study of pulmonary paragonimiasis in our institute over a period of two year. Results: it was observed that out of eleven cases, prevalence of paragonimiasis was almost equal among both the genders, with a mean age of 38.1 ± 16.96, affecting people from hills. Three patients were erroneously treated with antitubercular drugs without any relief. The association with eosinophilia in the peripheral blood and tissue[16] was seen in all the study subjects and majority patients had pleural fluid eosinophilia. Patients were diagnosed by serological test, Paragonimus ova in Sputum smear and Pleural fluid. All study subjects had excellent clinical responses to praziquantel given at dose of 25 mg/kg given orally 3 times daily for 3 consecutive days. Conclusions: There is a need to generate awareness among the clinicians and public regarding Paragonimiasis and to consider it in differential diagnosis of TB and carcinoma lung. Physicians should consider the possibility of paragonimiasis among patients who present with chest complaints with eosinophilia from the endemic regions.

  20. Music Teacher Licensure Candidates in the United States: A Demographic Profile and Analysis of Licensure Examination Scores

    Science.gov (United States)

    Elpus, Kenneth

    2015-01-01

    The purpose of this study was to analyze the demographic profile of candidates seeking music teacher licensure in the United States and to understand whether performance on the Praxis II music teacher licensure tests varies systematically as a function of various demographic characteristics. Praxis II music test data and background questionnaire…

  1. 团队人口统计特征多元化与绩效关系的元分析%A Meta-Analysis of the Relationship between Team Demographic Diversity and Team Performance

    Institute of Scientific and Technical Information of China (English)

    卫旭华; 刘咏梅; 陈思璇

    2015-01-01

    Over the past decades, team demographic diversity has become a topic of considerable interest to industrial and organizational psychology scholars and organizational managers. However, there is little consistent evidence regarding the relations between team demographic diversity and team performance. There are at least two potential reasons to explain these inconsistencies. First, there are different forms of team demographic diversity and the specific type of diversity should have different effects on team performance. For example, team demographic diversity can be categorized as separation, variety and disparity based on the statistical distribution of team members' characteristics. Second, past researchers suggest considering contextual issues in team demographic diversity research. Rather than test the direct relationship between team demographic diversity and team performance, they have pointed out that contextual factors (e.g., cultural context) should play an important moderating role in the relationship between team demographic diversity and team performance. In order to explain the inconsistencies in past research examining the link between team demographic diversity and team performance, we conducted a meta-analysis to examine the effects of different types of team demographic diversity on team performance. Our meta-analysis was based on 345 effect sizes from 137 Eastern and Western empirical studies with 79,639 teams. Each author independently coded the data and resolved discrepancies through discussion. In our coding system, we coded diversity as separation, variety, or disparity based on the measures of diversity used in each empirical paper. Further, we collected contextual data to examine the potential moderating effects of contextual factors, such as performance types, cultural context and team types. Results of main effects showed that team demographic variety had significantly positive effects on team performance, whereas team demographic

  2. What Do Deep Statistical Analysis on Gaming Motivation and Game Characteristics Clusters Reveal about Targeting Demographics when Designing Gamified Contents?

    Directory of Open Access Journals (Sweden)

    Alireza Tavakkoli

    2015-06-01

    Full Text Available This paper presents the comprehensive results of the study of a cohort of college graduate and undergraduate students who participated in playing a Massively Multiplayer Online Role Playing Game (MMORPG as a gameplay rich with social interaction as well as intellectual and aesthetic features. We present the full results of the study in the form of inferential statistics and a review of our descriptive statistics previously reported in [46]. Separate one-way independent-measures multivariate analysis of variance (MANOVA's were used to analyze the data from several instruments to determine if there were statistically significant differences first by gender, then by age group, and then by degree. Moreover, a one-way repeated-measures analysis of variance (ANOVA was used to determine if there was a statistically significant difference between the clusters in the 5 gaming clusters on the Game Characteristic Survey. Follow-up paired samples t-tests were used to see if there was a statistically significant difference between each of the 10 possible combinations of paired clusters. Our results support the hypotheses and outline the features that may need to be taken into account in support of tailoring gamified educational content targeting a certain demographic. Sections 1, 2, and 3 below from our pervious study [46] are included because this is the second part of the two-part study. [46] Tavakkoli, A., Loffredo, D., Ward, M., Sr. (2014. "Insights from Massively Multiplayer Online Role Playing Games to Enhance Gamification in Education", Journal of Systemics, Cybernetics, and Informatics, 12(4, 66-78.

  3. Molecular epidemiological analysis of Mycoplasma bovis isolates from the United Kingdom shows two genetically distinct clusters

    DEFF Research Database (Denmark)

    McAuliffe, Laura; Kokotovic, Branko; Ayling, Roger D.

    2004-01-01

    Mycoplasma bovis is an important veterinary pathogen causing pneumonia, arthritis, and mastitis in infected cattle. We investigated the genetic diversity of 53 isolates collected in the United Kingdom between 1996 and 2002 with pulsed-field gel electrophoresis (PFGE), amplified fragment length...... polymorphism (AFLP), and random amplified polymorphic DNA (RAPD) analysis. In addition, the influence of variable surface protein (Vsp) profiles on the profiles generated with molecular typing techniques was studied. Both AFLP and RAPD separated the isolates into two distinct groups, but PFGE showed less...

  4. Analysis of competition performance in dressage and show jumping of Dutch Warmblood horses.

    Science.gov (United States)

    Rovere, G; Ducro, B J; van Arendonk, J A M; Norberg, E; Madsen, P

    2016-12-01

    Most Warmblood horse studbooks aim to improve the performance in dressage and show jumping. The Dutch Royal Warmblood Studbook (KWPN) includes the highest score achieved in competition by a horse to evaluate its genetic ability of performance. However, the records collected during competition are associated with some aspects that might affect the quality of the genetic evaluation based on these records. These aspects include the influence of rider, censoring and preselection of the data. The aim of this study was to quantify the impact of rider effect, censoring and preselection on the genetic analysis of competition data of dressage and show jumping of KWPN. Different models including rider effect were evaluated. To assess the impact of censoring, genetic parameters were estimated in data sets that differed in the degree of censoring. The effect of preselection on variance components was analysed by defining a binary trait (sport-status) depending on whether the horse has a competition record or not. This trait was included in a bivariate model with the competition trait and used all horses registered by KWPN since 1984. Results showed that performance in competition for dressage and show jumping is a heritable trait (h(2) ~ 0.11-0.13) and that it is important to account for the effect of rider in the genetic analysis. Censoring had a small effect on the genetic parameter for highest performance achieved by the horse. A moderate heritability obtained for sport-status indicates that preselection has a genetic basis, but the effect on genetic parameters was relatively small.

  5. Network Analysis Shows Novel Molecular Mechanisms of Action for Copper-Based Chemotherapy

    Science.gov (United States)

    Espinal-Enríquez, Jesús; Hernández-Lemus, Enrique; Mejía, Carmen; Ruiz-Azuara, Lena

    2016-01-01

    The understanding of the mechanisms associated with the action of chemotherapeutic agents is fundamental to assess and account for possible side-effects of such treatments. Casiopeínas have demonstrated a cytotoxic effect by activation of pro-apoptotic processes in malignant cells. Such processes have been proved to activate the apoptotic intrinsic route, as well as cell cycle arrest. Despite this knowledge, the whole mechanism of action of Casiopeínas is yet to be completely understood. In this work we implement a systems biology approach based on two pathway analysis tools (Over-Representation Analysis and Causal Network Analysis) to observe changes in some hallmarks of cancer, induced by this copper-based chemotherapeutic agent in HeLa cell lines. We find that the metabolism of metal ions is exacerbated, as well as cell division processes being globally diminished. We also show that cellular migration and proliferation events are decreased. Moreover, the molecular mechanisms of liver protection are increased in the cell cultures under the actions of Casiopeínas, unlike the case in many other cytotoxic drugs. We argue that this chemotherapeutic agent may be promising, given its protective hepatic function, concomitant with its cytotoxic participation in the onset of apoptotic processes in malignant cells. PMID:26793116

  6. Proteome Analysis of the Plant Pathogenic Fungus Monilinia laxa Showing Host Specificity

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    Olja Bregar

    2012-01-01

    Full Text Available Brown rot fungus Monilinia laxa (Aderh. & Ruhl. Honey is an important plant pathogen in stone and pome fruits in Europe. We applied a proteomic approach in a study of M. laxa isolates obtained from apples and apricots in order to show the host specifity of the isolates and to analyse differentially expressed proteins in terms of host specifity, fungal pathogenicity and identification of candidate proteins for diagnostic marker development. Extracted mycelium proteins were separated by 2-D electrophoresis (2-DE and visualized by Coomassie staining in a non-linear pH range of 3–11 and Mr of 14–116 kDa. We set up a 2-DE reference map of M. laxa, resolving up to 800 protein spots, and used it for image analysis. The average technical coefficient of variance (13 % demonstrated a high reproducibility of protein extraction and 2-D polyacrylamide gel electrophoresis (2-DE PAGE, and the average biological coefficient of variance (23 % enabled differential proteomic analysis of the isolates. Multivariate statistical analysis (principal component analysis discriminated isolates from two different hosts, providing new data that support the existence of a M. laxa specialized form f. sp. mali, which infects only apples. A total of 50 differentially expressed proteins were further analyzed by LC-MS/MS, yielding 41 positive identifications. The identified mycelial proteins were functionally classified into 6 groups: amino acid and protein metabolism, energy production, carbohydrate metabolism, stress response, fatty acid metabolism and other proteins. Some proteins expressed only in apple isolates have been described as virulence factors in other fungi. The acetolactate synthase was almost 11-fold more abundant in apple-specific isolates than in apricot isolates and it might be implicated in M. laxa host specificity. Ten proteins identified only in apple isolates are potential candidates for the development of M. laxa host-specific diagnostic markers.

  7. Factors associated with infant mortality in Nepal: a comparative analysis of Nepal demographic and health surveys (NDHS) 2006 and 2011.

    Science.gov (United States)

    Lamichhane, Reeta; Zhao, Yun; Paudel, Susan; Adewuyi, Emmanuel O

    2017-01-10

    Infant mortality is one of the priority public health issues in developing countries like Nepal. The infant mortality rate (IMR) was 48 and 46 per 1000 live births for the year 2006 and 2011, respectively, a slight reduction during the 5 years' period. A comprehensive analysis that has identified and compared key factors associated with infant mortality is limited in Nepal, and, therefore, this study aims to fill the gap. Datasets from Nepal Demographic and Health Surveys (NDHS) 2006 and 2011 were used to identify and compare the major factors associated with infant mortality. Both surveys used multistage stratified cluster sampling techniques. A total of 8707 and 10,826 households were interviewed in 2006 and 2011, with more than 99% response rate in both studies. The survival information of singleton live-born infants born 5 years preceding the two surveys were extracted from the 'childbirth' dataset. Multiple logistic regression analysis using a hierarchical modelling approach with the backward elimination method was conducted. Complex Samples Analysis was used to adjust for unequal selection probability due to the multistage stratified cluster-sampling procedure used in both NDHS. Based on NDHS 2006, ecological region, succeeding birth interval, breastfeeding status and type of delivery assistance were found to be significant predictors of infant mortality. Infants born in hilly region (AOR = 0.43, p = 0.013) and with professional assistance (AOR = 0.27, p = 0.039) had a lower risk of mortality. On the other hand, infants with succeeding birth interval less than 24 months (AOR = 6.66, p = 0.001) and those who were never breastfed (AOR = 1.62, p = 0.044) had a higher risk of mortality. Based on NDHS 2011, birth interval (preceding and succeeding) and baby's size at birth were identified to be significantly associated with infant mortality. Infants born with preceding birth interval (AOR = 1.94, p = 0.022) or succeeding

  8. Dietary Diversity and Meal Frequency Practices among Infant and Young Children Aged 6–23 Months in Ethiopia: A Secondary Analysis of Ethiopian Demographic and Health Survey 2011

    Directory of Open Access Journals (Sweden)

    Melkam Aemro

    2013-01-01

    Full Text Available Background. Appropriate complementary feeding practice is essential for growth and development of children. This study aimed to assess dietary diversity and meal frequency practice of infants and young children in Ethiopia. Methods. Data collected in the Ethiopian Demographic and Health Survey (EDHS from December 2010 to June 2011 were used for this study. Data collected were extracted, arranged, recoded, and analyzed by using SPSS version 17. A total of 2836 children aged 6–23 months were used for final analysis. Both bivariate and multivariate analysis were done to identify predictors of feeding practices. Result. Children with adequate dietary diversity score and meal frequency were 10.8% and 44.7%, respectively. Children born from the richest households showed better dietary diversity score (OR = 0.256. Number of children whose age less than five years was important predictor of dietary diversity (OR = 0.690. Mothers who had exposure to media were more likely to give adequate meal frequency to their children (OR = 0.707. Conclusion. Dietary diversity and meal frequency practices were inadequate in Ethiopia. Wealth quintile, exposure to media, and number of children were affecting feeding practices. Improving economic status, a habit of eating together, and exposure to media are important to improve infant feeding practices in Ethiopia.

  9. "Let's Get This Party Started!": An Analysis of Health Risk Behavior on MTV Reality Television Shows.

    Science.gov (United States)

    Flynn, Mark A; Morin, David; Park, Sung-Yeon; Stana, Alexandru

    2015-01-01

    Past research has examined portrayals of risk behavior in various media, including television, advertising, and film. To address an underexplored area, this study analyzed drinking, smoking, and sexual activities in MTV reality programming popular among adolescent viewers from 2004 to 2011. Cast members' demographic attributes were also examined in relation to their risk behaviors. Results demonstrated that drinking and casual sexual behaviors were pervasive among cast members. Smoking and more intense sexual behaviors were also present, but to a smaller degree. Men and young adult cast members were more likely to engage in risk behaviors than women and teenage cast members. Also, ethnic/racial minority characters were shown drinking more often than were White cast members. Interpretations of these findings are discussed based in social cognitive theory and the concept of super peers. Implications for future research are provided.

  10. Poor thermal care practices among home births in Nepal: further analysis of Nepal Demographic and Health Survey 2011.

    Directory of Open Access Journals (Sweden)

    Vishnu Khanal

    Full Text Available INTRODUCTION: Hypothermia is a major factor associated with neonatal mortality in low and middle income countries. Thermal care protection of newborn through a series of measures taken at birth and during the initial days of life is recommended to reduce the hypothermia and associated neonatal mortality. This study aimed to identify the prevalence of and the factors associated with receiving 'optimum thermal care' among home born newborns of Nepal. METHODS: Data from the Nepal Demographic and Health Surveys (NDHS 2011 were used for this study. Women who reported a home birth for their most recent childbirth was included in the study. Factors associated with optimum thermal care were examined using Chi-square test followed by logistic regression. RESULTS: A total of 2464 newborns were included in the study. A total of 57.6 % were dried before the placenta was delivered; 60.3% were wrapped; 24.5% had not bathing during the first 24 hours, and 63.9% were breastfed within one hour of birth. Overall, only 248 (10.7%; 95% CI (8.8 %, 12.9% newborns received optimum thermal care. Newborns whose mothers had achieved higher education (OR 2.810; 95% CI (1.132, 6.976, attended four or more antenatal care visits (OR 2.563; 95% CI (1.309, 5.017, and those whose birth were attended by skilled attendants (OR 2.178; 95% CI (1.428, 3.323 were likely to receive optimum thermal care. CONCLUSION: The current study showed that only one in ten newborns in Nepal received optimum thermal care. Future newborn survival programs should focus on those mothers who are uneducated; who do not attend the recommended four or more attend antenatal care visits; and those who deliver without the assistance of skilled birth attendants to reduce the risk of neonatal hypothermia in Nepal.

  11. Analysis of allergen immunotherapy studies shows increased clinical efficacy in highly symptomatic patients

    DEFF Research Database (Denmark)

    Howarth, P; Malling, Hans-Jørgen; Molimard, M;

    2011-01-01

    To cite this article: Howarth P, Malling H-J, Molimard M, Devillier P. Analysis of allergen immunotherapy studies shows increased clinical efficacy in highly symptomatic patients. Allergy 2012; 67: 321-327. ABSTRACT: Background:  The assessment of allergen immunotherapy (AIT) efficacy...... in the treatment for seasonal allergic rhinoconjunctivitis (SAR) symptoms is challenging. Allergen immunotherapy differs from symptomatic therapy in that while symptomatic therapy treats patients after symptoms appear and aims to reduce symptoms, AIT is administered before symptoms are present and aims to prevent...... them. Thus, clinical studies of AIT can neither establish baseline symptom levels nor limit the enrolment of patients to those with the most severe symptoms. Allergen immunotherapy treatment effects are therefore diluted by patients with low symptoms for a particular pollen season. The objective...

  12. Proteomic analysis shows synthetic oleanane triterpenoid binds to mTOR.

    Directory of Open Access Journals (Sweden)

    Mark M Yore

    Full Text Available New multifunctional drugs that target multiple disease-relevant networks offer a novel approach to the prevention and treatment of many diseases. New synthetic oleanane triterpenoids (SO, such as CDDO (2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid and its derivatives, are multifunctional compounds originally developed for the prevention and treatment of inflammation and oxidative stress. However, the protein binding partners and mechanisms of action of these SO are not yet fully understood. Here we characterize the putative target profile of one SO, CDDO-Imidazolide (CDDO-Im, by combining affinity purification with mass spectroscopic proteomic analysis to identify 577 candidate binding proteins in whole cells. This SO pharmaco-interactome consists of a diverse but interconnected set of signaling networks; bioinformatic analysis of the protein interactome identified canonical signaling pathways targeted by the SO, including retinoic acid receptor (RAR, estrogen receptor (ER, insulin receptor (IR, janus kinase/signal transducers and activators of transcription (JAK/STAT, and phosphatase and tensin homolog (PTEN. Pull-down studies then further validated a subset of the putative targets. In addition, we now show for the first time that the mammalian target of rapamycin (mTOR is a direct target of CDDO-Im. We also show that CDDO-Im blocks insulin-induced activation of this pathway by binding to mTOR and inhibiting its kinase activity. Our basic studies confirm that the SO, CDDO-Im, acts on a protein network to elicit its pharmacological activity.

  13. Dental microwear texture analysis shows within-species diet variability in fossil hominins.

    Science.gov (United States)

    Scott, Robert S; Ungar, Peter S; Bergstrom, Torbjorn S; Brown, Christopher A; Grine, Frederick E; Teaford, Mark F; Walker, Alan

    2005-08-04

    Reconstructing the diets of extinct hominins is essential to understanding the paleobiology and evolutionary history of our lineage. Dental microwear, the study of microscopic tooth-wear resulting from use, provides direct evidence of what an individual ate in the past. Unfortunately, established methods of studying microwear are plagued with low repeatability and high observer error. Here we apply an objective, repeatable approach for studying three-dimensional microwear surface texture to extinct South African hominins. Scanning confocal microscopy together with scale-sensitive fractal analysis are used to characterize the complexity and anisotropy of microwear. Results for living primates show that this approach can distinguish among diets characterized by different fracture properties. When applied to hominins, microwear texture analysis indicates that Australopithecus africanus microwear is more anisotropic, but also more variable in anisotropy than Paranthropus robustus. This latter species has more complex microwear textures, but is also more variable in complexity than A. africanus. This suggests that A. africanus ate more tough foods and P. robustus consumed more hard and brittle items, but that both had variable and overlapping diets.

  14. HIV-1 phylogenetic analysis shows HIV-1 transits through the meninges to brain and peripheral tissues.

    Science.gov (United States)

    Lamers, Susanna L; Gray, Rebecca R; Salemi, Marco; Huysentruyt, Leanne C; McGrath, Michael S

    2011-01-01

    Brain infection by the human immunodeficiency virus type 1 (HIV-1) has been investigated in many reports with a variety of conclusions concerning the time of entry and degree of viral compartmentalization. To address these diverse findings, we sequenced HIV-1 gp120 clones from a wide range of brain, peripheral and meningeal tissues from five patients who died from several HIV-1 associated disease pathologies. High-resolution phylogenetic analysis confirmed previous studies that showed a significant degree of compartmentalization in brain and peripheral tissue subpopulations. Some intermixing between the HIV-1 subpopulations was evident, especially in patients that died from pathologies other than HIV-associated dementia. Interestingly, the major tissue harboring virus from both the brain and peripheral tissues was the meninges. These results show that (1) HIV-1 is clearly capable of migrating out of the brain, (2) the meninges are the most likely primary transport tissues, and (3) infected brain macrophages comprise an important HIV reservoir during highly active antiretroviral therapy.

  15. School Social Workers in Texas: A Comparative Demographic Analysis of the Texas-Mexico Border and Non-Border Regions

    Science.gov (United States)

    Garza, Cecilia; Landeck, Michael

    2007-01-01

    This study examines the role of school social workers as potential agents of change in the educational system, with a special focus on their major demographic characteristics in Texas and along the Mexico border region. The border region of the state has chronic poverty and limited educational attainment levels and demonstrates a need for…

  16. Analysis of the Socio-Demographic Structure and Thoughts of the Turkish Bilingual Children on "Bilingualism" in Germany

    Science.gov (United States)

    Kabadayi, Abdulkadir

    2008-01-01

    Two thirds of the world's population is bilingual to some extent, hence from an international perspective speaking more than one language is the norm rather than the exception. Germany, Bulgaria, Iraq are only a few of the countries where more than one language is widely spoken. This study aims to analyse the socio-demographic structure and second…

  17. Adult Learners in Higher Education: A Rural-Urban Analysis of Pennsylvania FAFSA Applicants' Educational, Demographic, and Financial Characteristics

    Science.gov (United States)

    Prins, Esther; Kassab, Cathy; Campbell, Kimeka

    2015-01-01

    This article paints a comprehensive portrait of the demographic, financial, and educational characteristics of Pennsylvania postsecondary students who are adult learners, and identifies rural-urban differences within this group. The study analyzed data from the 2010-11 Free Application for Federal Student Aid (n = 610,925), supplemented by…

  18. GED Recipients in Postsecondary Education: A Rural-Urban Analysis of Pennsylvania FAFSA Applicants' Educational, Demographic, and Financial Characteristics

    Science.gov (United States)

    Prins, Esther; Kassab, Cathy

    2015-01-01

    Transitions to postsecondary education for GED graduates are a growing concern for educators and policy makers. This article analyzes the educational, demographic, and financial characteristics of Pennsylvania postsecondary students with a GED credential compared with traditional high school graduates, and identifies rural-urban differences within…

  19. An Analysis of the Impact of Demographic, Structural, Student, and Financial Factors on Texas High School Mathematics Achievement

    Science.gov (United States)

    Carter, Alisa

    2013-01-01

    The purpose of this study was to examine the relationships of demographic (indicators describing student characteristics), structural (indicators describing school characteristics), student (indicators of student academic achievement), and financial (indicators of instructional expenditures) factors to student mathematics achievement. A sample (n…

  20. The Structure of Pathological Gambling among Korean Gamblers: A Cluster and Factor Analysis of Clinical and Demographic Characteristics

    Science.gov (United States)

    Lee, Tae Kyung; LaBrie, Richard A.; Grant, Jon E.; Kim, Suck Won; Shaffer, Howard J.

    2008-01-01

    This paper reports the underlying structure of the demographic and clinical characteristics of level 3 (i.e., pathological) Korean casino gamblers. The participants reported their gambling behavior and clinical characteristics known to be associated with gambling problems (e.g., alcohol use problems, eating disorders, depression, anxiety, and…

  1. School Social Workers in Texas: A Comparative Demographic Analysis of the Texas-Mexico Border and Non-Border Regions

    Science.gov (United States)

    Garza, Cecilia; Landeck, Michael

    2007-01-01

    This study examines the role of school social workers as potential agents of change in the educational system, with a special focus on their major demographic characteristics in Texas and along the Mexico border region. The border region of the state has chronic poverty and limited educational attainment levels and demonstrates a need for…

  2. Cooperative genome-wide analysis shows increased homozygosity in early onset Parkinson's disease.

    Directory of Open Access Journals (Sweden)

    Javier Simón-Sánchez

    Full Text Available Parkinson's disease (PD occurs in both familial and sporadic forms, and both monogenic and complex genetic factors have been identified. Early onset PD (EOPD is particularly associated with autosomal recessive (AR mutations, and three genes, PARK2, PARK7 and PINK1, have been found to carry mutations leading to AR disease. Since mutations in these genes account for less than 10% of EOPD patients, we hypothesized that further recessive genetic factors are involved in this disorder, which may appear in extended runs of homozygosity.We carried out genome wide SNP genotyping to look for extended runs of homozygosity (ROHs in 1,445 EOPD cases and 6,987 controls. Logistic regression analyses showed an increased level of genomic homozygosity in EOPD cases compared to controls. These differences are larger for ROH of 9 Mb and above, where there is a more than three-fold increase in the proportion of cases carrying a ROH. These differences are not explained by occult recessive mutations at existing loci. Controlling for genome wide homozygosity in logistic regression analyses increased the differences between cases and controls, indicating that in EOPD cases ROHs do not simply relate to genome wide measures of inbreeding. Homozygosity at a locus on chromosome19p13.3 was identified as being more common in EOPD cases as compared to controls. Sequencing analysis of genes and predicted transcripts within this locus failed to identify a novel mutation causing EOPD in our cohort.There is an increased rate of genome wide homozygosity in EOPD, as measured by an increase in ROHs. These ROHs are a signature of inbreeding and do not necessarily harbour disease-causing genetic variants. Although there might be other regions of interest apart from chromosome 19p13.3, we lack the power to detect them with this analysis.

  3. Overweight and obesity among women: analysis of demographic and health survey data from 32 Sub-Saharan African Countries.

    Science.gov (United States)

    Neupane, Subas; Prakash, K C; Doku, David Teye

    2016-01-13

    Overweight and obesity are risk factors for many chronic diseases globally. However, the extent of the problem in low-income countries like Sub-Saharan Africa is unclear. We assessed the magnitude and disparity of both phenomena by place of residence, level of education and wealth quintile using cross-sectional data from 32 countries. Demographic and Health Survey (DHS) data collected in 32 Sub-Saharan African countries between January 2005 and December 2013 were used. A total of 250651 women (aged 15-49 years) were analyzed. Trained personnel using a standardized procedure measured body weight and height. Body mass index (BMI) was calculated by dividing body weight by height squared. Prevalence of overweight (25.0-29.9 kg/m(2)) and obesity (≥ 30.0 kg/m(2)) were estimated for each country. Analysis of the relationships of overweight and obesity with place of residence, education and wealth index were carried out using logistic regression. The pooled prevalence of overweight for the region was 15.9% (95% CI, 15.7-16.0) with the lowest in Madagascar 5.6% (95% CI, 5.1-6.1) and the highest in Swaziland 27.7% (95% CI, 26.4-29.0). Similarly, the prevalence of obesity was also lowest in Madagascar 1.1% (95% CI, 0.9-1.4) and highest in Swaziland 23.0 (95% CI, 21.8-24.2). The women in urban residence and those who were classified as rich, with respect to the quintile of the wealth index, had higher likelihood of overweight and obesity. In the pooled results, high education was significantly associated with overweight and obesity. The prevalence of overweight and obesity varied highly between the countries and wealth index (rich vs. poor) was found to be the strongest predictor in most of the countries. Interventions that will address the socio-cultural barriers to maintaining healthy body size can contribute to curbing the overweight and obesity epidemic in Africa.

  4. Demographics and Scholarly Productivity of American Board of Anesthesiology Volunteers: Results of an Internet-Based Bibliometric Analysis.

    Science.gov (United States)

    Pagel, Paul S

    2016-10-01

    The American Board of Anesthesiology (ABA) has been responsible for certification of anesthesiologists since 1938. Selected ABA diplomates provide their expertise to write the ABA's written and oral examinations and to administer the oral examination required for primary certification. The demographics, administrative and educational duties, and scholarly productivity of ABA volunteers and their dependence on subspecialty certification, transesophageal echocardiography (TEE) credentials, and grant funding are unknown. Observational study. Internet analysis. ABA volunteers who participated in the 2015 primary certification examinations identified from the 2016 issue of ABA News. None. The 2016 issue of ABA News was downloaded from the public ABA website and was used to identify all volunteers who participated in any aspect of the 2015 primary certification process. Each individual's practice type, faculty rank if applicable, and affiliation were identified using Google with the keyword "anesthesiology." The practice location, time, and interval after original ABA certification; additional ABA subspecialty certification; the number of publications and citations; publication rate; citations per publication; and the H-, M-, and i-10 indices were obtained using the ABA and Scopus databases. Credentials in TEE were identified for each individual using the National Board of Echocardiography database. National Institutes of Health (NIH) and Foundation for Anesthesia Education and Research (FAER) funding for each volunteer was evaluated using NIH Research Portfolio Online Reporting Tools and the FAER alumni databases, respectively. Three hundred ninety-three ABA volunteers were identified and analyzed. Three hundred ten individuals currently hold academic appointments (83.5%), whereas 83 (16.5%) hold private practice or military positions. Sixty-seven volunteers have major administrative roles (eg, dean, chief executive officer, associate or assistant dean, chair, vice

  5. Proteomic Analysis of Rice Leaves Shows the Different Regulations to Osmotic Stress and Stress Signals

    Institute of Scientific and Technical Information of China (English)

    Lie-Bo Shu; Wei Ding; Jin-Hong Wu; Fang-Jun Feng; Li-Jun Luo; Han-Wei Mei

    2010-01-01

    Following the idea of partial root-zone drying(PRD)in crop cultivation,the morphological and physiological responses to partial root osmotic stress(PROS)and whole root osmotic stress(WROS)were investigated in rice.WROS caused stress symptoms like leaf rolling and membrane leakage.PROS stimulated stress signals,but did not cause severe leaf damage.By proteomic analysis,a total of 58 proteins showed differential expression after one or both treatments,and functional classification of these proteins suggests that stress signals regulate photosynthesis,carbohydrate and energy metabolism.Two other proteins(anthranilate synthase and submergence-induced nickel-binding protein)were upregulated only in the PROS plants,indicating their important roles in stress resistance.Additionally,more enzymes were involved in stress defense,redox homeostasis,lignin and ethylene synthesis in WROS leaves,suggesting a more comprehensive regulatory mechanism induced by osmotic stress.This study provides new insights into the complex molecular networks within plant leaves involved in the adaptation to osmotic stress and stress signals.

  6. Analysis of experimental evidence that shows adverse effects of salt and its relation to hypertension

    Directory of Open Access Journals (Sweden)

    Ignacio Bravo A.

    2012-02-01

    Full Text Available The study by Taylor et al published in June 2010 in the American Journal of Hypertension questions the effectiveness of reducing salt intake in the diet in the prevention and treatment of high blood pressure and other cardiovascular conditions. The publication of this article has lead to great controversy and medical associations and learned societies responded promptly. The response criticized the results of the meta-analysis and pointed out its methodological shortcomings. In this review we critically appraise the experimental evidence that shows the importance of diet salt intake and its role as a determinant of blood pressure. We briefly describe the paradigm that explains the role of salt intake in contributing in the regulation of blood pressure (Guyton hypothesis and model and we mention the experimental evidence that supports this. We briefly comment on the classical studies that indicate that salt intake (NaCl contributes directly to the development of high blood pressure and target tissues. Finally, we briefly mention the experimental data that is related with the controversy on the role of salt (NaCl or sodium as prohypertensive agents.

  7. DEMOGRAPHIC VULNERABILITIES IN TECUCI PLAIN

    Directory of Open Access Journals (Sweden)

    Iulian Adrian ŞORCARU

    2013-06-01

    Full Text Available The study focuses on analyzing and mapping 8 indicators considered to best reflect the demographic vulnerability in Tecuci Plain in the year 2010 and proposes a model of aggregation which finally allows us to distinguish three major types of demographic vulnerability (low, medium and high. Mapping the final values also shows significant disparities in the territorial administrative units that broadly overlap the plain, the most vulnerable being Tecuci city and the peripheral communes, towards Vrancea and Vaslui Counties.

  8. Impact Of Maternal Socio-Economic Determinants On Early Childhood Stunting In Maldives An Analysis Of Maldives Demographic Health Survey 2009

    Directory of Open Access Journals (Sweden)

    Aminath Adeela

    2015-08-01

    Full Text Available Under nutrition is a direct consequence of poverty with its characteristics of low socio-economic status poor living conditions poor maternal education large family size inadequate access to quality food safe water and health services. Recently there have been significant improvements in the overall health of the Maldivian population with an increase in life expectancy and a decline in maternal and infant mortality rates. However infant under nutrition is still a concern. Field testing of WHO growth standards in 2006 in Maldives indicated that more than one third of children under five years were stunted and that children classified as tall hardly reach the WHO standard for mean height. Examining maternal characteristics that may contribute to under nutrition in Maldivian children will assist in designingimplementing population based public health interventions aimed at improving infant and childhood nutrition. This study is based on secondary analysis of data from the Maldives Demographic Health Survey MDHS 2009. The study results showed that height for age z-score was lowest from ages 6 to 29 months. Factors significantly associated with the rate of stunting included size of child at birth height of the mother duration of breastfeeding difficulties in obtaining money needed for medical help for mother absence of a health service provider when obtaining medical help for mother after adjusting for socio-economic factors.

  9. Trends of modern contraceptive use among young married women based on the 2000, 2005, and 2011 Ethiopian Demographic and Health Surveys: a multivariate decomposition analysis.

    Directory of Open Access Journals (Sweden)

    Abebaw Gebeyehu Worku

    Full Text Available INTRODUCTION: Accessing family planning can reduce a significant proportion of maternal, infant, and childhood deaths. In Ethiopia, use of modern contraceptive methods is low but it is increasing. This study aimed to analyze the trends and determinants of changes in modern contraceptive use over time among young married women in Ethiopia. METHODS: The study used data from the three Demographic Health Surveys conducted in Ethiopia, in 2000, 2005, and 2011. Young married women age 15-24 years with sample sizes of 2,157 in 2000, 1,904 in 2005, and 2,146 in 2011 were included. Logit-based decomposition analysis technique was used for analysis of factors contributing to the recent changes. STATA 12 was employed for data management and analyses. All calculations presented in this paper were weighted for the sampling probabilities and non-response. Complex sampling procedures were also considered during testing of statistical significance. RESULTS: Among young married women, modern contraceptive prevalence increased from 6% in 2000 to 16% in 2005 and to 36% in 2011. The decomposition analysis indicated that 34% of the overall change in modern contraceptive use was due to difference in women's characteristics. Changes in the composition of young women's characteristics according to age, educational status, religion, couple concordance on family size, and fertility preference were the major sources of this increase. Two-thirds of the increase in modern contraceptive use was due to difference in coefficients. Most importantly, the increase was due to change in contraceptive use behavior among the rural population (33% and among Orthodox Christians (16% and Protestants (4%. CONCLUSIONS: Modern contraceptive use among young married women has showed a remarkable increase over the last decade in Ethiopia. Programmatic interventions targeting poor, younger (adolescent, illiterate, and Muslim women would help to maintain the increasing trend in modern

  10. Impact of socio-demographic factors on the mitigating actions for climate change: a path analysis with mediating effects of attitudinal variables.

    Science.gov (United States)

    Masud, Muhammad Mehedi; Akhatr, Rulia; Nasrin, Shamima; Adamu, Ibrahim Mohammed

    2017-09-25

    Socio-demographic factors play a significant role in increasing the individual's climate change awareness and in setting a favorable individual attitude towards its mitigation. To better understand how the adversative effects of climate change can be mitigated, this study attempts to investigate the impact of socio-demographic factors on the mitigating actions of the individuals (MAOI) on climate change. Qualitative data were collected from a face-to-face survey of 360 respondents in the Kuala Lumpur region of Malaysia through a close-ended questionnaire. Analysis was conducted on the mediating effects of attitudinal variables through the path model by using the SEM. Findings indicate that the socio-demographic factors such as gender, age, education, income, and ethnicity can greatly influence the individual's awareness, attitude, risk perception, and knowledge of climate change issues. The results drawn from this study also revealed that the attitudinal factors act as a mediating effect between the socio-demographic factors and the MAOI, thereby, indicating that both the socio-demographic factors and the attitudinal factors have significant effects on the MAOI towards climate change. The outcome of this study can help policy makers and other private organizations to decide on the appropriate actions to take in managing climate change effects. These actions which encompass improving basic climate change education and making the public more aware of the local dimensions of climate change are important for harnessing public engagement and support that can also stimulate climate change awareness and promote mitigating actions to n protect the environment from the impact of climate change.

  11. Episodes of falling among elderly people: a systematic review and meta-analysis of social and demographic pre-disposing characteristics

    Directory of Open Access Journals (Sweden)

    F. Bloch

    2010-01-01

    Full Text Available CONTEXT: The multifactorial nature of falls among elderly people is well-known. Identifying the social-demographic characteristics of elderly people who fall would enable us to define the typical profile of the elderly who are at risk of falling. OBJECTIVE: We aimed to isolate studies in which the social-demographic risk factors for falls among the elderly have been evaluated and to carry out a meta-analysis by combining the results of all of these selected studies. METHOD: We did a systematic literature review using the key words "accidental fall / numerical data" and "risk factors." Inclusion criteria entailed the selection of articles with the following characteristics: population of subjects aged 60 years or over, falls that took place in everyday life, and social-demographic risk factors for falls. RESULTS: 3,747 indexed articles published between 1981 and 2007 were identified, and 177 studies with available data were included, of which 129 had data on social-demographic risk factors for falls. Difficulties in activities of daily living (ADL or in instrumental activities of daily living (IADL double the risk of falling: The OR and 95% Cl were 2.26 (2.09, 2.45 for disturbance ADL and 2.10 (1.68, 2.64 for IADL. The OR and 95% Cl for Caucasians were 1.68 (0.98 - 2.88 and 0.64 (0.51 - 0.80 for Hispanics. In the subgroup of patients older than eighty, being married protected people from falling with an OR and 95% Cl =0.68 (0.53 - 0.87. CONCLUSION: Defining factors that create a risk of falling and protect elderly people from falls using social-demographic characteristics lets us focus on an "at risk" population for which a specific program could be developed.

  12. Demographic variables in coal miners’ safety attitude

    Science.gov (United States)

    Yin, Wen-wen; Wu, Xiang; Ci, Hui-Peng; Qin, Shu-Qi; Liu, Jia-Long

    2017-03-01

    To change unsafe behavior through adjusting people’s safety attitudes has become an important measure to prevent accidents. Demographic variables, as influential factors of safety attitude, are fundamental and essential for the research. This research does a questionnaire survey among coal mine industry workers, and makes variance analysis and correlation analysis of the results in light of age, length of working years, educational level and experiences of accidents. The results show that the coal miners’ age, length of working years and accident experiences correlate lowly with safety attitudes, and those older coal miners with longer working years have better safety attitude, as coal miners without experiences of accident do.However, educational level has nothing to do with the safety attitude. Therefore, during the process of safety management, coal miners with different demographic characteristics should be put more attention to.

  13. A spatial analysis of population dynamics and climate change in Africa: potential vulnerability hot spots emerge where precipitation declines and demographic pressures coincide

    Science.gov (United States)

    López-Carr, David; Pricope, Narcisa G.; Aukema, Juliann E.; Jankowska, Marta M.; Funk, Christopher C.; Husak, Gregory J.; Michaelsen, Joel C.

    2014-01-01

    We present an integrative measure of exposure and sensitivity components of vulnerability to climatic and demographic change for the African continent in order to identify “hot spots” of high potential population vulnerability. Getis-Ord Gi* spatial clustering analyses reveal statistically significant locations of spatio-temporal precipitation decline coinciding with high population density and increase. Statistically significant areas are evident, particularly across central, southern, and eastern Africa. The highly populated Lake Victoria basin emerges as a particularly salient hot spot. People located in the regions highlighted in this analysis suffer exceptionally high exposure to negative climate change impacts (as populations increase on lands with decreasing rainfall). Results may help inform further hot spot mapping and related research on demographic vulnerabilities to climate change. Results may also inform more suitable geographical targeting of policy interventions across the continent.

  14. Explaining marital patterns and trends in namibia: a regression analysis of 1992, 2000 and 2006 demographic and survey data.

    Directory of Open Access Journals (Sweden)

    Lillian Pazvakawambwa

    Full Text Available BACKGROUND: Marriage is a significant event in life-course of individuals, and creates a system that characterizes societal and economic structures. Marital patterns and dynamics over the years have changed a lot, with decreasing proportions of marriage, increased levels of divorce and co-habitation in developing countries. Although, such changes have been reported in African societies including Namibia, they have largely remained unexplained. OBJECTIVES AND METHODS: IN THIS PAPER, WE EXAMINED TRENDS AND PATTERNS OF MARITAL STATUS OF WOMEN OF MARRIAGEABLE AGE: 15 to 49 years, in Namibia using the 1992, 2000 and 2006 Demographic and Health Survey (DHS data. Trends were established for selected demographic variables. Two binary logistic regression models for ever-married versus never married, and cohabitation versus married were fitted to establish factors associated with such nuptial systems. Further a multinomial logistic regression models, adjusted for bio-demographic and socio-economic variables, were fitted separately for each year, to establish determinants of type of union (never married, married and cohabitation. RESULTS AND CONCLUSIONS: Findings indicate a general change away from marriage, with a shift in singulate mean age at marriage. Cohabitation was prevalent among those less than 30 years of age, the odds were higher in urban areas and increased since 1992. Be as it may marriage remained a persistent nuptiality pattern, and common among the less educated and employed, but lower odds in urban areas. Results from multinomial model suggest that marital status was associated with age at marriage, total children born, region, place of residence, education level and religion. We conclude that marital patterns have undergone significant transformation over the past two decades in Namibia, with a coexistence of traditional marriage framework with co-habitation, and sizeable proportion remaining unmarried to the late 30s. A shift in the

  15. EPA Analysis Shows 2014 Decrease of Toxic Chemical Releases in Maine

    Science.gov (United States)

    EPA's most recent Toxic Release Inventory (TRI) data is now available for the reporting year of 2014. In Maine, the reporting data show that overall releases of pollutants to the environment decreased since the previous reporting year (2013).

  16. EPA Analysis Shows 2014 Decrease of Toxic Chemical Releases in Massachusetts

    Science.gov (United States)

    EPA’s most recent Toxic Release Inventory (TRI) data is now available for the reporting year of 2014. In Massachusetts, the reporting data show that overall releases of pollutants to the environment decreased since the previous reporting year (2013).

  17. EPA Analysis Shows 2014 Decrease of Toxic Chemical Releases in Connecticut

    Science.gov (United States)

    EPA’s most recent Toxic Release Inventory (TRI) data is now available for the reporting year of 2014. In Connecticut, the reporting data show that overall releases of pollutants to the environment decreased since the previous reporting year (2013).

  18. Show me the money: cost-benefit analysis in the work environment.

    Science.gov (United States)

    Levenstein, Charles; Dunn, Mary Lee

    2005-01-01

    During the last several decades, Cost-Benefit Analysis (CBA) has become a widely used technique in public policy-making. This review examines CBA from perspectives of both advocates and critics; it looks at its theory and practice, its purported advantages and shortcomings in application. It also proposes several ways in which the process can be made more accountable.

  19. Deeper insight into maternal genetic assessments and demographic history for Egyptian indigenous chicken populations using mtDNA analysis

    Directory of Open Access Journals (Sweden)

    Marwa A. Eltanany

    2016-09-01

    Full Text Available This study principally sought to reveal the demographic expansion of Egyptian indigenous chickens (EIC using representative breeds: Sinai (North, Fayoumi (Middle and Dandarawi (South of Egypt as well as to deeply clarify their genetic diversity, possible matrilineal origin and dispersal routes. A total of 33 partial mitochondrial DNA sequences were generated from EIC and compared with a worldwide reference dataset of 1290 wild and domestic chicken sequences. Study populations had 12 polymorphic variable sites and 7 haplotypes. A lack of maternal substructure between EIC was detected (FST = 0.003. The unimodal mismatch distribution and negative values of Tajima’s D (−0.659 and Fu’s Fs (−0.157 indicated demographic expansion among EIC and pointed to Fayoumi as the oldest EIC population. Egyptian haplotypes were clustered phylogenetically into two divergent clades. Their phylogeography revealed an ancient single maternal lineage of Egyptian chickens likely derived from Indian-Subcontinent. Moreover, a recent maternal commercial heritage possibly originated in Yunnan-Province and/or surrounding areas was admixed restrictedly into Sinai. It is implied that Egypt was an entry point for Indian chicken into Africa and its further dispersal route to Europe. This study provides a clue supporting the previous assumption that urged utilizing consistent founder populations having closely related progenitors for synthetizing a stabilized homogenous crossbreed as a sustainable discipline in breeding program.

  20. The Impact of Adventure Based Activity at Malaysian National Service Training Programme on Team Cohesion: A Demographic Analysis.

    Directory of Open Access Journals (Sweden)

    Jaffry Zakaria

    2012-12-01

    Full Text Available The present study examines the effects of physical module elements (adventure based activity included in the Malaysian National Service Programme and to investigate the socio-demographic variables impact on team cohesion building among the participants. In this study, the participants were selected from three different camps, namely, Tasoh camp, Guar Chenderai camp and Meranti camp, located in the state of Perlis, Malaysia. The participants were those from the second batch intake in the year 2007. The sample sizes comprised of 994 participants (480=males, 514=females. The present study applied a pre-test and post-test design. The group was tested before and after the programme. This design was chosen because it could measure the impacts of the adventure-based activity towards team cohesion over time through the pre- and post-test scores (Berg & Latin, 2004. The variables comprised of the demographic factors (age, gender and place of residence, which included team cohesion were measured by Group Environmental Questionnaire (GEQ (Carron, Widmeyer, & Brawley, 1985. Results indicated that the participants of the National Service Training Programme underwent group cohesion change during the Physical Module activities (adventure based activities that were carried out at the camp. The changes were observable based on the statistically analyzed data during the pre and post-test.

  1. Meta-analysis of diffusion tensor imaging (DTI) studies shows altered fractional anisotropy occurring in distinct brain areas in association with depression

    LENUS (Irish Health Repository)

    Murphy, Melissa L

    2011-09-27

    Abstract Fractional anisotropy anomalies occurring in the white matter tracts in the brains of depressed patients may reflect microstructural changes underlying the pathophysiology of this disorder. We conducted a meta-analysis of fractional anisotropy abnormalities occurring in major depressive disorder using voxel-based diffusion tensor imaging studies. Using the Embase, PubMed and Google Scholar databases, 89 relevant data sets were identified, of which 7 (including 188 patients with major depressive disorder and 221 healthy controls) met our inclusion criteria. Authors were contacted to retrieve any additional data required. Coordinates were extracted from clusters of significant white matter fractional anisotropy differences between patients and controls. Relevant demographic, clinical and methodological variables were extracted from each study or obtained directly from authors. The meta-analysis was carried out using Signed Differential Mapping. Patients with depression showed decreased white matter fractional anisotropy values in the superior longitudinal fasciculus and increased fractional anisotropy values in the fronto-occipital fasciculus compared to controls. Using quartile and jackknife sensitivity analysis, we found that reduced fractional anisotropy in the left superior longitudinal fasciculus was very stable, with increases in the right fronto-occipital fasciculus driven by just one study. In conclusion, our meta-analysis revealed a significant reduction in fractional anisotropy values in the left superior longitudinal fasciculus, which may ultimately play an important role in the pathology of depression.

  2. Meta-analysis of diffusion tensor imaging studies shows altered fractional anisotropy occurring in distinct brain areas in association with depression.

    LENUS (Irish Health Repository)

    Murphy, Melissa L

    2011-09-01

    Fractional anisotropy anomalies occurring in the white matter tracts in the brains of depressed patients may reflect microstructural changes underlying the pathophysiology of this disorder. We conducted a meta-analysis of fractional anisotropy abnormalities occurring in major depressive disorder using voxel-based diffusion tensor imaging studies. Using the Embase, PubMed and Google Scholar databases, 89 relevant data sets were identified, of which 7 (including 188 patients with major depressive disorder and 221 healthy controls) met our inclusion criteria. Authors were contacted to retrieve any additional data required. Coordinates were extracted from clusters of significant white matter fractional anisotropy differences between patients and controls. Relevant demographic, clinical and methodological variables were extracted from each study or obtained directly from authors. The meta-analysis was carried out using Signed Differential Mapping. Patients with depression showed decreased white matter fractional anisotropy values in the superior longitudinal fasciculus and increased fractional anisotropy values in the fronto-occipital fasciculus compared to controls. Using quartile and jackknife sensitivity analysis, we found that reduced fractional anisotropy in the left superior longitudinal fasciculus was very stable, with increases in the right fronto-occipital fasciculus driven by just one study. In conclusion, our meta-analysis revealed a significant reduction in fractional anisotropy values in the left superior longitudinal fasciculus, which may ultimately play an important role in the pathology of depression.

  3. Regional Differentiation of The Demographic Potential in Italy and Poland

    Directory of Open Access Journals (Sweden)

    Pastuszka Sławomir

    2017-09-01

    Full Text Available The aim of this paper is to compare the demographic potential of given Italian and Polish regions. The analysis shows that the demographic situation in Poland, unlike in Italy, is not directly related to the level of development of some regions and their geographical location. In Italy, the unfavorable demographic situation is typical of most of the less-developed southern regions, whereas in Poland it occurs in voivodships with different economic potential, situated in different parts of the country. This is probably the result of the current polycentric development of Poland, characteristic of a centralized economy, and the polar development in Italy. Certain demographic similarities, but of different levels, related to the dynamics of the population, the level of fertility, and net migration are observable in the macro-regions of Mezzogiorno and Eastern Poland.

  4. Analysis of Gender Differences in Color Reaction in TV Show You Are the One

    Institute of Scientific and Technical Information of China (English)

    乔芳

    2015-01-01

    The differences between men and women is not only biological sex but social gender.Gender gap is produced in a biased society where men and women treated differently behave differently.This paper wishes to analyze different reactions to color of both sexes by taking examples from TV show You Are the One to further gender studies.

  5. Analysis of competition performance in dressage and show jumping of Dutch Warmblood horses

    NARCIS (Netherlands)

    Rovere, G.; Ducro, B.J.; Arendonk, van J.A.M.; Norberg, E.; Madsen, P.

    2016-01-01

    Most Warmblood horse studbooks aim to improve the performance in dressage and show jumping. The Dutch Royal Warmblood Studbook (KWPN) includes the highest score achieved in competition by a horse to evaluate its genetic ability of performance. However, the records collected during competition are

  6. EPA Analysis Shows 2014 Decrease of Toxic Chemical Releases in New Hampshire

    Science.gov (United States)

    EPA’s most recent Toxic Release Inventory (TRI) data is now available for the reporting year of 2014. In New Hampshire, the reporting data show that overall releases of pollutants to the environment decreased since the previous reporting year (2013).

  7. Economic impact and market analysis of a special event: The Great New England Air Show

    Science.gov (United States)

    Rodney B. Warnick; David C. Bojanic; Atul Sheel; Apurv Mather; Deepak. Ninan

    2010-01-01

    We conducted a post-event evaluation for the Great New England Air Show to assess its general economic impact and to refine economic estimates where possible. In addition to the standard economic impact variables, we examined travel distance, purchase decision involvement, event satisfaction, and frequency of attendance. Graphic mapping of event visitors' home ZIP...

  8. Molecular Analysis of Mixed Endometrial Carcinomas Shows Clonality in Most Cases.

    Science.gov (United States)

    Köbel, Martin; Meng, Bo; Hoang, Lien N; Almadani, Noorah; Li, Xiaodong; Soslow, Robert A; Gilks, C Blake; Lee, Cheng-Han

    2016-02-01

    Mixed endometrial carcinoma refers to a tumor that comprises 2 or more distinct histotypes. We studied 18 mixed-type endometrial carcinomas-11 mixed serous and low-grade endometrioid carcinomas (SC/EC), 5 mixed clear cell and low-grade ECs (CCC/EC), and 2 mixed CCC and SCs (CCC/SC), using targeted next-generation sequencing and immunohistochemistry to compare the molecular profiles of the different histotypes present in each case. In 16 of 18 cases there was molecular evidence that both components shared a clonal origin. Eight cases (6 EC/SC, 1 EC/CCC, and 1 SC/CCC) showed an SC molecular profile that was the same in both components. Five cases (3 CCC/EC and 2 SC/EC) showed a shared endometrioid molecular profile and identical mismatch-repair protein deficiency in both components. A single SC/EC case harbored the same POLE exonuclease domain mutation in both components. One SC/CCC and 1 EC/CCC case showed both shared and unique molecular features in the 2 histotype components, suggesting early molecular divergence from a common clonal origin. In 2 cases, there were no shared molecular features, and these appear to be biologically unrelated synchronous tumors. Overall, these results show that the different histologic components in mixed endometrial carcinomas typically share the same molecular aberrations. Mixed endometrial carcinomas most commonly occur through morphologic mimicry, whereby tumors with serous-type molecular profile show morphologic features of EC or CCC, or through underlying deficiency in DNA nucleotide repair, with resulting rapid accrual of mutations and intratumoral phenotypic heterogeneity. Less commonly, mixed endometrial carcinomas are the result of early molecular divergence from a common progenitor clone or are synchronous biologically unrelated tumors (collision tumors).

  9. TP53*P72 allele influences negatively female life expectancy in a population of central Italy: cross-sectional study and genetic-demographic approach analysis.

    Science.gov (United States)

    Di Pietro, Fabio; Dato, Serena; Carpi, Francesco M; Corneveaux, Jason J; Serfaustini, Simona; Maoloni, Sebastiano; Mignini, Fiorenzo; Huentelman, Matthew J; Passarino, Giuseppe; Napolioni, Valerio

    2013-05-01

    The association of TP53 P72R (rs1042522) with longevity remains uncertain and varies with ethnicity. Here, we tested its association with longevity in a cross-sectional population of Central Italy (18-106 years, N = 1,072), by integrating demographic information and frequency data to account for the different survival rates between sexes through the application of a genetic-demographic approach. rs1042522 affects females longevity, showing significant associations in Comparison 2 (Age Class 3 [>91 years] vs Age Class 2 [73-91 years]) under both additive (odds ratio [OR] 0.574; p = .006) and dominant (OR 0.513; p = .006) models. The TP53*P72 allele is significantly underrepresented in Age Class 3 only in women (OR 0.575; p = .008). The genetic-demographic approach demonstrated that the frequency of female TP53*P72 carriers underwent a significant reduction after 82 years (OR 0.586; p = .002). The same analyses gave nonsignificant results in men. The discrepancies among the results obtained on rs1042522 for longevity could result from the pleiotropic effects of p53 and the potential ethnic variation of its functional variants.

  10. SR-FTIR Coupled with Principal Component Analysis Shows Evidence for the Cellular Bystander Effect.

    Science.gov (United States)

    Lipiec, E; Bambery, K R; Lekki, J; Tobin, M J; Vogel, C; Whelan, D R; Wood, B R; Kwiatek, W M

    2015-07-01

    Synchrotron radiation-Fourier transform infrared (SR-FTIR) microscopy coupled with multivariate data analysis was used as an independent modality to monitor the cellular bystander effect. Single, living prostate cancer PC-3 cells were irradiated with various numbers of protons, ranging from 50-2,000, with an energy of either 1 or 2 MeV using a proton microprobe. SR-FTIR spectra of cells, fixed after exposure to protons and nonirradiated neighboring cells (bystander cells), were recorded. Spectral differences were observed in both the directly targeted and bystander cells and included changes in the DNA backbone and nucleic bases, along with changes in the protein secondary structure. Principal component analysis (PCA) was used to investigate the variance in the entire data set. The percentage of bystander cells relative to the applied number of protons with two different energies was calculated. Of all the applied quantities, the dose of 400 protons at 2 MeV was found to be the most effective for causing significant macromolecular perturbation in bystander PC-3 cells.

  11. Complete genome sequence analysis of goatpox virus isolated from China shows high variation.

    Science.gov (United States)

    Zeng, Xiancheng; Chi, Xuelin; Li, Wei; Hao, Wenbo; Li, Ming; Huang, Xiaohong; Huang, Yifan; Rock, Daniel L; Luo, Shuhong; Wang, Shihua

    2014-09-17

    Goatpox virus (GTPV), a member of the Capripoxvirus genus of the Poxviridae family, is the causative agent of variolo caprina (goatpox). GTPV can cause significant economic losses of domestic ruminants in endemic regions and can threaten breeding stocks. In this study, we report on the compilation of the complete genomic sequence of an isolated GTPV field strain FZ (GTPV_FZ). The 150,194bp GTPV genome consists of a central coding region bounded by two identical 2301bp inverted terminal repeats and contains 151 putative genes. Comparative genomic analysis reveals the apparent genetic relationships among Capripoxviruses are close, but sufficient genomic variants in the field isolate strain FZ have been identified to distinguish it from other GTPV strains and other Capripoxvirus species. Phylogenetic analysis based on the p32 and complete GTPV genome can be used to differentiate SPPVs, GTPVs and LSDVs. These data may contribute to the epidemiological study of the Chinese capripoxvirus and help to develop more specific detection methods to distinguish GTPVs, SPPVs and LSDVs.

  12. Demographic trends in Sweden

    Directory of Open Access Journals (Sweden)

    2004-08-01

    Full Text Available In the present note, we present the main features of recent trends in vital family-demographic behavior in Sweden. For this purpose, published indices of marriage, divorce, and childbearing risks by calendar year are updated by adding another two or three years of observation to our series. We demonstrate that the latest trend reversal in Swedish birth rates, which occurred at the end of the 1990s, continued to manifest itself in increasing propensities for childbearing during the early years of the 21st century. The rise pertains to all birth orders. Marriage propensities showed an increase as well, however, to a large extent expressed in a short-term development that was prevalent at the turn of the millennium. The previous long-term trend of rising divorce risks leveled off during the first two years of the new century.

  13. A micro-epidemiological analysis of febrile malaria in Coastal Kenya showing hotspots within hotspots.

    Science.gov (United States)

    Bejon, Philip; Williams, Thomas N; Nyundo, Christopher; Hay, Simon I; Benz, David; Gething, Peter W; Otiende, Mark; Peshu, Judy; Bashraheil, Mahfudh; Greenhouse, Bryan; Bousema, Teun; Bauni, Evasius; Marsh, Kevin; Smith, David L; Borrmann, Steffen

    2014-04-24

    Malaria transmission is spatially heterogeneous. This reduces the efficacy of control strategies, but focusing control strategies on clusters or 'hotspots' of transmission may be highly effective. Among 1500 homesteads in coastal Kenya we calculated (a) the fraction of febrile children with positive malaria smears per homestead, and (b) the mean age of children with malaria per homestead. These two measures were inversely correlated, indicating that children in homesteads at higher transmission acquire immunity more rapidly. This inverse correlation increased gradually with increasing spatial scale of analysis, and hotspots of febrile malaria were identified at every scale. We found hotspots within hotspots, down to the level of an individual homestead. Febrile malaria hotspots were temporally unstable, but 4 km radius hotspots could be targeted for 1 month following 1 month periods of surveillance.DOI: http://dx.doi.org/10.7554/eLife.02130.001. Copyright © 2014, Bejon et al.

  14. Differential temperature Carnot heat analysis shows that computing machines are thermodynamically irreversible

    Science.gov (United States)

    Parker, Michael C.; Walker, Stuart D.

    2008-07-01

    We perform a differential temperature Carnot analysis of the changes in energy and entropy (degrees of freedom) associated with an ideal classical computing machine. Assuming that Carnot's maximum efficiency law is as equally applicable to a computing machine as to a mechanical machine, we find that useful computation is necessarily dissipative and thermodynamically irreversible. In addition, we find that copying or cloning of information is as dissipative as the original process employed to create the information (through a computation) in the first place. We prove minimum heat dissipation kT ln 2 per output calculation bit, where T is the thermodynamic temperature of unavoidable by-product bits (i.e. not the output calculation bits) rather than a generally assumed 'surrounding environment' temperature. Overall, this places computers into the same category as conventional machines, obeying the second law of thermodynamics and always operating below 100% efficiency, such that a perpetual calculating machine cannot exist.

  15. Genome-wide microarray analysis of tomato roots showed defined responses to iron deficiency

    Directory of Open Access Journals (Sweden)

    Zamboni Anita

    2012-03-01

    Full Text Available Abstract Background Plants react to iron deficiency stress adopting different kind of adaptive responses. Tomato, a Strategy I plant, improves iron uptake through acidification of rhizosphere, reduction of Fe3+ to Fe2+ and transport of Fe2+ into the cells. Large-scale transcriptional analyses of roots under iron deficiency are only available for a very limited number of plant species with particular emphasis for Arabidopsis thaliana. Regarding tomato, an interesting model species for Strategy I plants and an economically important crop, physiological responses to Fe-deficiency have been thoroughly described and molecular analyses have provided evidence for genes involved in iron uptake mechanisms and their regulation. However, no detailed transcriptome analysis has been described so far. Results A genome-wide transcriptional analysis, performed with a chip that allows to monitor the expression of more than 25,000 tomato transcripts, identified 97 differentially expressed transcripts by comparing roots of Fe-deficient and Fe-sufficient tomato plants. These transcripts are related to the physiological responses of tomato roots to the nutrient stress resulting in an improved iron uptake, including regulatory aspects, translocation, root morphological modification and adaptation in primary metabolic pathways, such as glycolysis and TCA cycle. Other genes play a role in flavonoid biosynthesis and hormonal metabolism. Conclusions The transcriptional characterization confirmed the presence of the previously described mechanisms to adapt to iron starvation in tomato, but also allowed to identify other genes potentially playing a role in this process, thus opening new research perspectives to improve the knowledge on the tomato root response to the nutrient deficiency.

  16. Demographic characterization and spatial cluster analysis of human Salmonella 1,4,[5],12:i:- infections in Portugal: A 10year study.

    Science.gov (United States)

    Seixas, R; Nunes, T; Machado, J; Tavares, L; Owen, S P; Bernardo, F; Oliveira, M

    2017-06-30

    Salmonella 1,4,[5],12:i:- is presently considered one of the major serovars responsible for human salmonellosis worldwide. Due to its recent emergence, studies assessing the demographic characterization and spatial epidemiology of salmonellosis 1,4,[5],12:i:- at local- or country-level are lacking. In this study, a analysis was conducted over a 10year period, from 2000 to the first quarter of 2011 at the Portuguese National Laboratory in Portugal mainland, with a total of 215 Salmonella 1,4,[5],12:i:- serotyped isolates obtained from human infections by a passive surveillance system. Data regarding source, year and month of sampling, gender, age, district and municipality of the patients were registered. Descriptive statistical analysis and a spatial scan statistic combined with a geographic information system were employed to characterize the epidemiology and identify spatial clusters. Results showed that most districts have reports of Salmonella 1,4,[5],12:i:-, with a higher number of cases at the Portuguese coastland, including districts like Porto (n=60, 27.9%), Lisboa (n=29, 13.5%) and Aveiro (n=28, 13.0%). An increased incidence was observed in the period from 2004 to 2011 and most infections occurred during May and October. Spatial analysis revealed 4 clusters of higher than expected infection rates. Three were located in the north of Portugal, including two at the coastland (Cluster 1 [RR=3.58, p≤0.001] and 4 [RR=10.42 p≤0.230]), and one at the countryside (Cluster 3 [RR=17.76, p≤0.001]). A larger cluster was detected involving the center and south of Portugal (Cluster 2 [RR=4.85, p≤0.001]). The present study was elaborated with data provided by a passive surveillance system, which may originate an underestimation of disease burden. However, this is the first report describing the incidence and the distribution of areas with higher risk of infection in Portugal, revealing that Salmonella 1,4,[5],12:i:- displayed a significant geographic clustering

  17. PCR-DGGE analysis of the bacterial composition of a kaolin slurry showing altered rheology.

    Science.gov (United States)

    Papp, Ildikó; Balázs, Margit; Tombácz, Etelka; Babcsán, Norbert; Kesserű, Péter; Kiss, István; Szvetnik, Attila

    2012-04-01

    Kaolin is an important industrial raw material and a basis of a range of different products. Microbial spoilage is a detrimental process observed especially in kaolin slurries, leading to low quality products and economic loss. Although the alteration of kaolin slurries in ceramic industry was observed, the process and the microbial background have not been analyzed in details. This study provides the first data using a cultivation independent molecular biological approach (PCR-DGGE) regarding the bacterial composition of an altered kaolin slurry. The results show that potential exopolymer (EPS) producer bacteria (e.g. Acinetobacter, Pseudomonas) appear in the altered kaolin slurry, which may have an important role in the modification of kaolin slurries.

  18. Transcriptome Analysis Showed a Differential Signature between Invasive and Non-invasive Corticotrophinomas

    Science.gov (United States)

    de Araújo, Leonardo Jose Tadeu; Lerario, Antonio Marcondes; de Castro, Margaret; Martins, Clarissa Silva; Bronstein, Marcello Delano; Machado, Marcio Carlos; Trarbach, Ericka Barbosa; Villares Fragoso, Maria Candida Barisson

    2017-01-01

    ACTH-dependent hypercortisolism caused by a pituitary adenoma [Cushing’s disease (CD)] is the most common cause of endogenous Cushing’s syndrome. CD is often associated with several morbidities, including hypertension, diabetes, osteoporosis/bone fractures, secondary infections, and increased cardiovascular mortality. While the majority (≈80%) of the corticotrophinomas visible on pituitary magnetic resonance imaging are microadenomas (MICs, hypopituitarism and visual defects. Given the clinical and molecular heterogeneity of corticotrophinomas, the aim of this study was to investigate the pattern of genetic differential expression between MIC and MAC, including the invasiveness grade as a criterion for categorizing these tumors. In this study, were included tumor samples from patients with clinical, laboratorial, radiological, and histopathological diagnosis of hypercortisolism due to an ACTH-producing pituitary adenoma. Differential gene expression was studied using an Affymetrix microarray platform in 12 corticotrophinomas, classified as non-invasive MIC (n = 4) and MAC (n = 5), and invasive MAC (n = 3), according to modified Hardy criteria. Somatic mutations in USP8 were also investigated, but none of the patients exhibited USP8 variants. Differential expression analysis demonstrated that non-invasive MIC and MAC have a similar genetic signature, while invasive MACs exhibited a differential expression profile. Among the genes differentially expressed, we highlighted CCND2, ZNF676, DAPK1, and TIMP2, and their differential expression was validated through quantitative real-time PCR in another cohort of 15 non-invasive and 3 invasive cortocotrophinomas. We also identified potential biological pathways associated with growth and invasiveness, TGF-β and G protein signaling pathways, DNA damage response pathway, and pathways associated with focal adhesion. Our study revealed a differential pattern of genetic signature in a subgroup of MAC

  19. Genome-wide expression analysis of soybean MADS genes showing potential function in the seed development.

    Directory of Open Access Journals (Sweden)

    Cheng-Ming Fan

    Full Text Available The MADS family is an ancient and best-studied transcription factor and plays fundamental roles in almost every developmental process in plants. In the plant evolutionary history, the whole genome duplication (WGD events are important not only to the plant species evolution, but to expansion of members of the gene families. Soybean as a model legume crop has experience three rounds of WGD events. Members of some MIKC(C subfamilies, such as SOC, AGL6, SQUA, SVP, AGL17 and DEF/GLO, were expanded after soybean three rounds of WGD events. And some MIKC(C subfamilies, MIKC* and type I MADS families had experienced faster birth-and-death evolution and their traces before the Glycine WGD event were not found. Transposed duplication played important roles in tandem arrangements among the members of different subfamilies. According to the expression profiles of type I and MIKC paralog pair genes, the fates of MIKC paralog gene pairs were subfunctionalization, and the fates of type I MADS paralog gene pairs were nonfunctionalization. 137 out of 163 MADS genes were close to 186 loci within 2 Mb genomic regions associated with seed-relative QTLs, among which 115 genes expressed during the seed development. Although MIKC(C genes kept the important and conserved functions of the flower development, most MIKC(C genes showed potentially essential roles in the seed development as well as the type I MADS.

  20. Analysis of patterns of patient compliance after an abnormal Pap smear result: the influence of demographic characteristics on patient compliance.

    Science.gov (United States)

    Rojas, Christine; Zhou, Ming K; Khamis, Harry J; Amesse, Lawrence

    2013-07-01

    This study aimed to determine population characteristics that correlate to suboptimal follow-up after an abnormal cervical cytology result. Nonpregnant women, ages 21 to 65 years, with newly diagnosed abnormal cervical cytology result between January 2009 and January 2012 at an urban clinic were eligible for inclusion in this retrospective chart review. Cervical cytology data and demographic characteristics such as age, ethnicity, employment, marital and smoking status, health insurance and number of pregnancies were abstracted from electronic medical record. A log-linear model was used to determine which factors influenced patient compliance. Of the total of 206 women, 78 (37.9%) had optimal follow-up and 128 (62.1%) had suboptimal follow-up. The 3 variables that were statistically significant in influencing patient follow-up after adjusted analyses included severity of cytology result (p = .0013), ethnicity (p = .02), and employment status (p = .0159). The risk ratio for optimal follow-up for those with severe cytology result was 1.81; for the non-whites, 1.77; and for the employed, 1.53. Ethnicity, severity of cervical cytology result, and employment status play an important role in patient follow-up after an abnormal cervical cytology result. Detecting trends in our patient population that influence adherence to follow-up will help health care providers formulate strategies that target this problem.

  1. A 10-year study of specimens submitted to oral pathology laboratory analysis: lesion occurrence and demographic features

    Directory of Open Access Journals (Sweden)

    Marina Mendez

    2012-06-01

    Full Text Available The purpose of the present paper was to describe the range of lesions histologically diagnosed in an oral pathology laboratory in southern Brazil. A retrospective study of 8,168 specimen analyses recorded between 1995 and 2004 was conducted. The records were retrieved from the Oral Pathology Laboratory, School of Dentistry, Federal University of Rio Grande do Sul, RS, Brazil. A total of 6,831 valid cases (83.63% were examined. Of these, inflammatory lesions were the most common occurrences (n = 4,320; 63.24%. Benign and malignant tumors accounted for 7.66% (n = 523 and 1.9% (n = 130 of the occurrences, respectively. Significant associations were observed between nonneoplastic proliferative disorders and benign mesenchymal tumors in females, and between squamous cell carcinoma and leukoplakia in males. Most diagnoses were benign in nature and had an inflammatory etiology. The association of some demographic characteristics with the occurrence of lesions suggests that these characteristics should be considered in performing differential diagnoses.

  2. A 10-year study of specimens submitted to oral pathology laboratory analysis: lesion occurrence and demographic features.

    Science.gov (United States)

    Mendez, Marina; Carrard, Vinicius Coelho; Haas, Alex Nogueira; Lauxen, Isabel da Silva; Barbachan, João Jorge Diniz; Rados, Pantelis Varvaki; Sant'Ana Filho, Manoel

    2012-01-01

    The purpose of the present paper was to describe the range of lesions histologically diagnosed in an oral pathology laboratory in southern Brazil. A retrospective study of 8,168 specimen analyses recorded between 1995 and 2004 was conducted. The records were retrieved from the Oral Pathology Laboratory, School of Dentistry, Federal University of Rio Grande do Sul, RS, Brazil. A total of 6,831 valid cases (83.63%) were examined. Of these, inflammatory lesions were the most common occurrences (n = 4,320; 63.24%). Benign and malignant tumors accounted for 7.66% (n = 523) and 1.9% (n = 130) of the occurrences, respectively. Significant associations were observed between nonneoplastic proliferative disorders and benign mesenchymal tumors in females, and between squamous cell carcinoma and leukoplakia in males. Most diagnoses were benign in nature and had an inflammatory etiology. The association of some demographic characteristics with the occurrence of lesions suggests that these characteristics should be considered in performing differential diagnoses.

  3. The association between socio-demographic characteristics and adherence to breast and colorectal cancer screening: Analysis of large sub populations

    Directory of Open Access Journals (Sweden)

    Vainer Anna

    2011-08-01

    Full Text Available Abstract Background Populations having lower socioeconomic status, as well as ethnic minorities, have demonstrated lower utilization of preventive screening, including tests for early detection of breast and colorectal cancer. The objective To explore socio-demographic disparities in adherence to screening recommendations for early detection of cancer. Methods The study was conducted by Maccabi Healthcare Services, an Israeli HMO (health plan providing healthcare services to 1.9 million members. Utilization of breast cancer (BC and colorectal cancer (CC screening were analyzed by socio-economic ranks (SERs, ethnicity (Arab vs non-Arab, immigration status and ownership of voluntarily supplemental health insurance (VSHI. Results Data on 157,928 and 303,330 adults, eligible for BC and CC screening, respectively, were analyzed. Those having lower SER, Arabs, immigrants from Former Soviet Union countries and non-owners of VSHI performed fewer cancer screening examinations compared with those having higher SER, non-Arabs, veterans and owners of VSHI (p Conclusion Patients from low socio-economic backgrounds, Arabs, immigrants and those who do not own supplemental insurance do fewer tests for early detection of cancer. These sub-populations should be considered priority populations for targeted intervention programs and improved resource allocation.

  4. Diversity in the Emerging Critical Care Workforce: Analysis of Demographic Trends in Critical Care Fellows From 2004 to 2014.

    Science.gov (United States)

    Lane-Fall, Meghan B; Miano, Todd A; Aysola, Jaya; Augoustides, John G T

    2017-05-01

    Diversity in the physician workforce is essential to providing culturally effective care. In critical care, despite the high stakes and frequency with which cultural concerns arise, it is unknown whether physician diversity reflects that of critically ill patients. We sought to characterize demographic trends in critical care fellows, who represent the emerging intensivist workforce. We used published data to create logistic regression models comparing annual trends in the representation of women and racial/ethnic groups across critical care fellowship types. United States Accreditation Council on Graduate Medical Education-approved residency and fellowship training programs. Residents and fellows employed by Accreditation Council on Graduate Medical Education-accredited training programs from 2004 to 2014. None. From 2004 to 2014, the number of critical care fellows increased annually, up 54.1% from 1,606 in 2004-2005 to 2,475 in 2013-2014. The proportion of female critical care fellows increased from 29.5% (2004-2005) to 38.3% (2013-2014) (p workforce reflect underrepresentation of women and racial/ethnic minorities. Trends highlight increases in women and Hispanics and stable or decreasing representation of non-Hispanic underrepresented minority critical care fellows. Further research is needed to elucidate the reasons underlying persistent underrepresentation of racial and ethnic minorities in critical care fellowship programs.

  5. Social Differences in Infant Mortality in 19th Century RostockA Demographic Analysis Based on Church Records

    Directory of Open Access Journals (Sweden)

    Michael Mühlichen

    2015-03-01

    Full Text Available The article examines the historical development of infant mortality in the Hanseatic city of Rostock, with a special focus on the question of how socio-economic factors influenced infant mortality in the early 19th century. Compared with the rest of Germany, the city exhibited an exceedingly low infant mortality level, in particular in the first third of the century. Our analyses show that the occupation of the father had a significant influence on the survival probability of a child in the first year of life in the early 19th century. Newborn children of fathers in lower ranked occupations exhibited a greater mortality risk in the first year of life than the offspring of fathers with occupations of higher status. The analyses are based on the registries of burials and baptisms of St. James’s Church (Jakobikirche in Rostock, which are largely preserved and much of which has been digitalised. Based on these individual data, this is the first event history analysis model conducted in the context of infant mortality in a German city in the 19th century. This article is also the first to reveal Rostock infant mortality rates for the entire 19th century according to sex, thus closing two research gaps.

  6. Determinants of moderate-to-severe anaemia among women of reproductive age in Tanzania: analysis of data from the 2010 Tanzania Demographic and Health Survey.

    Science.gov (United States)

    Wilunda, Calistus; Massawe, Siriel; Jackson, Caroline

    2013-12-01

    To identify determinants of moderate-to-severe anaemia among women of reproductive age in Tanzania. We included participants from the 2010 Tanzania Demographic and Health Survey, which collected data on socio-demographic and maternal health and determined haemoglobin levels from blood samples. We performed logistic regression to calculate adjusted odds ratios for associations between socio-demographic, contextual, reproductive and lifestyle factors, and moderate-to-severe anaemia and investigated interactions between certain risk factors. Of 9477 women, 20.1% were anaemic. Pregnancy was significantly associated with anaemia (adjusted OR 1.75, 95% CI 1.43-2.15), but the effect varied significantly by urban/rural residence, wealth and education. The effect of pregnancy was stronger in women without education and those who were in lower wealth groups, with significant interactions observed for each of these factors. Education was associated with a lower anaemia risk, particularly in the poorest group (OR 0.58, 95% CI 0.43-0.80), and in pregnant women. The risk of anaemia fell with rising iron supplementation coverage. Lack of toilet facilities increased anaemia risk (OR 1.26, 95% CI 1.00-1.60), whereas using hormonal contraception reduced it. There was no association with age, urban/rural residence, wealth or type of cooking fuel in adjusted analysis. Pregnant women in Tanzania are particularly at risk of moderate-to-severe anaemia, with the effect modified by urban/rural residence, education and wealth. Prevention interventions should target women with lower education or without proper sanitation facilities, and women who are pregnant, particularly if they are uneducated or in lower wealth groups. © 2013 John Wiley & Sons Ltd.

  7. Complementary feeding practices and child growth outcomes in Haiti: an analysis of data from Demographic and Health Surveys.

    Science.gov (United States)

    Heidkamp, Rebecca A; Ayoya, Mohamed Ag; Teta, Ismael Ngnie; Stoltzfus, Rebecca J; Marhone, Joseline Pierre

    2015-10-01

    The Haitian National Nutrition Policy identifies the promotion of optimal complementary feeding (CF) practices as a priority action to prevent childhood malnutrition. We analysed data from the nationally representative 2005-2006 Haiti Demographic Health Survey using the World Health Organization 2008 infant and young child feeding indicators to describe feeding practices among children aged 6-23 months and thus inform policy and programme planning. Multivariate regression analyses were used to identify the determinants of CF practices and to examine their association with child growth outcomes. Overall, 87.3% of 6-8-month-olds received soft, solid or semi-solid foods in the previous 24 h. Minimum dietary diversity (MDD), minimum meal frequency (MMF) and minimum acceptable diet (MAD) were achieved in 29.2%, 45.3% and 17.1% of children aged 6-23 months, respectively. Non-breastfed children were more likely to achieve MDD than breastfed children of the same age (37.3% vs. 25.8%; P < 0.001). The proportion of children achieving MMF varied significantly by age (P < 0.001). Children with overweight mothers were more likely to achieve MDD, MMF and MAD [odds ratio (OR) 2.08, P = 0.012; OR 1.81, P = 0.02; and OR 2.4, P = 0.01, respectively] than children of normal weight mothers. Odds of achieving MDD and MMF increased with household wealth. Among mothers with secondary or more education, achieving MDD or MAD was significantly associated with lower mean weight-for-age z-score and height-for-age z-score (P-value <0.05 for infants and young child feeding indicator × maternal education interaction). CF practices were mostly inadequate and contributed to growth faltering among Haitian children 6-23 months old.

  8. Geospatial analysis of naturally occurring boundaries in road-transport emissions and children's respiratory health across a demographically diverse cityscape.

    Science.gov (United States)

    Jephcote, Calvin; Chen, Haibo

    2013-04-01

    The motor-vehicle is accountable for emitting a substantial concoction of air quality objective pollutants and carcinogenic hydrocarbons within close proximity to urbanised residential districts. The spatial extent of health impacts associated with road-transport pollutants have traditionally been explored through the examination of artificially created buffers, defined by subjective distances from specified major road links. Within this paper an alternative approach is presented using boundary statistics, which describe naturally occurring shifts of magnitude in socio-environmental and health outcomes across the wider urban area. In contrast, previous distance-threshold investigations have used arbitrarily sized buffers placed upon predetermined locations in response to environmental attributes, without considering the combined influence of additional social burdens. The demographically diverse City of Leicester, situated within the heart of the United Kingdom's major road-transport network, was selected to showcase such methods. Descriptive multilevel modelling strategies accommodating for generalised spatial structures across Leicester, globally associated issues of deprivation, road-transport emissions and ethnic minorities with increased respiratory risks. Getis-Ord Gi* spatial pattern recognition statistics identified the existence of localised variations, with inner city neighbourhoods tending to house children of ethnic minority groups whom experience disproportionately large environmental and respiratory health burdens. Crisp polygon wombling boundary detection across Leicester appeared to broadly complement the Gi* statistics, identifying naturally occurring boundaries in road-transport emissions to result in elevated children's respiratory admissions within a distance of 283 m (P < 0.05). The designated threshold was identified to reduce in relation to certain ethnic groups, thus suggesting environmental injustices likely prevail within the model

  9. Neonatal mortality in East Africa and West Africa: a geographic analysis of district-level demographic and health survey data

    Directory of Open Access Journals (Sweden)

    Sue C. Grady

    2017-05-01

    Full Text Available Under-five child mortality declined 47% since 2000 following the implementation of the United Nation’s (UN Millennium Development Goals. To further reduce under-five child mortality, the UN’s Sustainable Development Goals (SDGs will focus on interventions to address neonatal mortality, a major contributor of under-five mortality. The African region has the highest neonatal mortality rate (28.0 per 1000 live births, followed by that of the Eastern Mediterranean (26.6 and South-East Asia (24.3. This study used the Demographic and Health Survey Birth Recode data (http://dhsprogram.com/data/File-Types-and-Names.cfm to identify high-risk districts and countries for neonatal mortality in two sub-regions of Africa – East Africa and West Africa. Geographically weighted Poisson regression models were estimated to capture the spatially varying relationships between neonatal mortality and dimensions of potential need i care around the time of delivery, ii maternal education, and iii women’s empowerment. In East Africa, neonatal mortality was significantly associated with home births, mothers without an education and mothers whose husbands decided on contraceptive practices, controlling for rural residency. In West Africa, neonatal mortality was also significantly associated with home births, mothers with a primary education and mothers who did not want or plan their last child. Importantly, neonatal mortality associated with home deliveries were explained by maternal exposure to unprotected water sources in East Africa and older maternal age and female sex of infants in West Africa. Future SDG-interventions may target these dimensions of need in priority high-risk districts and countries, to further reduce the burden of neonatal mortality in Africa.

  10. Weather and mortality: a 10 year retrospective analysis of the Nouna Health and Demographic Surveillance System, Burkina Faso

    Directory of Open Access Journals (Sweden)

    Rainer Sauerborn

    2012-11-01

    Full Text Available Background: A growing body of evidence points to the emission of greenhouse gases from human activity as a key factor in climate change. This in turn affects human health and wellbeing through consequential changes in weather extremes. At present, little is known about the effects of weather on the health of sub-Saharan African populations, as well as the related anticipated effects of climate change partly due to scarcity of good quality data. We aimed to study the association between weather patterns and daily mortality in the Nouna Health and Demographic Surveillance System (HDSS area during 1999–2009. Methods: Meteorological data were obtained from a nearby weather station in the Nouna HDSS area and linked to mortality data on a daily basis. Time series Poisson regression models were established to estimate the association between the lags of weather and daily population-level mortality, adjusting for time trends. The analyses were stratified by age and sex to study differential population susceptibility. Results: We found profound associations between higher temperature and daily mortality in the Nouna HDSS, Burkina Faso. The short-term direct heat effect was particularly strong on the under-five child mortality rate. We also found independent coherent effects and strong associations between rainfall events and daily mortality, particularly in elderly populations. Conclusion: Mortality patterns in the Nouna HDSS appear to be closely related to weather conditions. Further investigation on cause-specific mortality, as well as on vulnerability and susceptibility is required. Studies on local adaptation and mitigation measures to avoid health impacts from weather and climate change is also needed to reduce negative effects from weather and climate change on population health in rural areas of the sub-Saharan Africa.

  11. Characteristics Of Street Children In Cameroon: A Situational Analysis Of Demographic, Socio-Economic And Behavioural Profiles And Challenges

    Directory of Open Access Journals (Sweden)

    Samuel N. Cumber

    2016-03-01

    Full Text Available Introduction: The issue of street children is one of the global social problems rising in low- and middle-income countries. These children are vulnerable, but because of a lack of sufficient information, it is very difficult for stakeholders to address their plight in Cameroon.Aim: To examine the situation and characteristics of street children in three Cameroonian cities.Objectives: To describe the demographic, socio-economic and behavioural profiles of street children. To identify challenges of street children and to compare the results from the three cities on account of their different settings, cultural history and challenges.Materials and methods: The study was an analytical cross-sectional survey conducted through researcher-administered questionnaires to 399 street children (homeless for at least a month, in three Cameroonian cities from 1 January 2015 to 30 March 2015.Results: The majority of the participants were boys, more than 70% were homeless for less than 12 months and poverty was found to be the most common reason for being on the street. Most of the participants earned less than 500CFA francs (USD 0.85, with many of them resorting to begging, drug abuse, sex work and other risky behaviours. Only two of the respondents (0.5% regarded the public attitude towards them as supportive.Conclusion: As children roam the streets in search of shelter, food and other basic needs, their future hangs in the balance. Understanding the plight of street children highlights the need for immediate design and implementation of intervention strategies to prevent children from living in the streets and assist those who have become street children.

  12. Characteristics Of Street Children In Cameroon: A Situational Analysis Of Demographic, Socio-Economic And Behavioural Profiles And Challenges

    Directory of Open Access Journals (Sweden)

    Samuel N. Cumber

    2016-03-01

    Full Text Available Introduction: The issue of street children is one of the global social problems rising in low- and middle-income countries. These children are vulnerable, but because of a lack of sufficient information, it is very difficult for stakeholders to address their plight in Cameroon.Aim: To examine the situation and characteristics of street children in three Cameroonian cities.Objectives: To describe the demographic, socio-economic and behavioural profiles of street children. To identify challenges of street children and to compare the results from the three cities on account of their different settings, cultural history and challenges.Materials and methods: The study was an analytical cross-sectional survey conducted through researcher-administered questionnaires to 399 street children (homeless for at least a month, in three Cameroonian cities from 1 January 2015 to 30 March 2015.Results: The majority of the participants were boys, more than 70% were homeless for less than 12 months and poverty was found to be the most common reason for being on the street. Most of the participants earned less than 500CFA francs (USD 0.85, with many of them resorting to begging, drug abuse, sex work and other risky behaviours. Only two of the respondents (0.5% regarded the public attitude towards them as supportive.Conclusion: As children roam the streets in search of shelter, food and other basic needs, their future hangs in the balance. Understanding the plight of street children highlights the need for immediate design and implementation of intervention strategies to prevent children from living in the streets and assist those who have become street children.

  13. Characteristics Of Street Children In Cameroon: A Situational Analysis Of Demographic, Socio-Economic And Behavioural Profiles And Challenges.

    Science.gov (United States)

    Cumber, Samuel N; Tsoka-Gwegweni, Joyce M

    2016-11-18

    The issue of street children is one of the global social problems rising in low- and middle-income countries. These children are vulnerable, but because of a lack of sufficient information, it is very difficult for stakeholders to address their plight in Cameroon. To examine the situation and characteristics of street children in three Cameroonian cities. To describe the demographic, socio-economic and behavioural profiles of street children. To identify challenges of street children and to compare the results from the three cities on account of their different settings, cultural history and challenges. The study was an analytical cross-sectional survey conducted through researcher-administered questionnaires to 399 street children (homeless for at least a month), in three Cameroonian cities from 1 January 2015 to 30 March 2015. The majority of the participants were boys, more than 70% were homeless for less than 12 months and poverty was found to be the most common reason for being on the street. Most of the participants earned less than 500CFA francs (USD 0.85), with many of them resorting to begging, drug abuse, sex work and other risky behaviours. Only two of the respondents (0.5%) regarded the public attitude towards them as supportive. As children roam the streets in search of shelter, food and other basic needs, their future hangs in the balance. Understanding the plight of street children highlights the need for immediate design and implementation of intervention strategies to prevent children from living in the streets and assist those who have become street children.

  14. Inference of population structure and demographic history in Taxodium distichum, a coniferous tree in North America, based on amplicon sequence analysis

    Science.gov (United States)

    Ikezaki, Yuka; Suyama, Yoshihisa; Middleton, Beth A.; Tsumura, Yoshihiko; Teshima, Kousuke; Tachida, Hidenori; Kusumi, Junko

    2016-01-01

    PREMISE OF THE STUDY: Studies of natural genetic variation can elucidate the genetic basis of phenotypic variation and the past population structure of species. Our study species, Taxodium distichum, is a unique conifer that inhabits the flood plains and swamps of North America. Morphological and ecological differences in two varieties, T. distichum var. distichum (bald cypress) and T. distichum var. imbricarium (pond cypress), are well known, but little is known about the level of genetic differentiation between the varieties and the demographic history of local populations.METHODS: We analyzed nucleotide polymorphisms at 47 nuclear loci from 96 individuals collected from the Mississippi River Alluvial Valley (MRAV), and Gulf Coastal populations in Texas, Louisiana, and Florida using high-throughput DNA sequencing. Standard population genetic statistics were calculated, and demographic parameters were estimated using a composite-likelihood approach.KEY RESULTS: Taxodium distichum in North America can be divided into at least three genetic groups, bald cypress in the MRAV and Texas, bald cypress in Florida, and pond cypress in Florida. The levels of genetic differentiation among the groups were low but significant. Several loci showed the signatures of positive selection, which might be responsible for local adaptation or varietal differentiation.CONCLUSIONS: Bald cypress was genetically differentiated into two geographical groups, and the boundary was located between the MRAV and Florida. This differentiation could be explained by population expansion from east to west. Despite the overlap of the two varieties’ ranges, they were genetically differentiated in Florida. The estimated demographic parameters suggested that pond cypress split from bald cypress during the late Miocene.

  15. Inferences of population structure and demographic history for Taxodium distichum, a coniferous tree in North America, based on amplicon sequencing analysis.

    Science.gov (United States)

    Ikezaki, Yuka; Suyama, Yoshihisa; Middleton, Beth A; Tsumura, Yoshihiko; Teshima, Kousuke; Tachida, Hidenori; Kusumi, Junko

    2016-11-01

    Studies of natural genetic variation can elucidate the genetic basis of phenotypic variation and the past population structure of species. Our study species, Taxodium distichum, is a unique conifer that inhabits the flood plains and swamps of North America. Morphological and ecological differences in two varieties, T. distichum var. distichum (bald cypress) and T. distichum var. imbricarium (pond cypress), are well known, but little is known about the level of genetic differentiation between the varieties and the demographic history of local populations. We analyzed nucleotide polymorphisms at 47 nuclear loci from 96 individuals collected from the Mississippi River Alluvial Valley (MRAV), and Gulf Coastal populations in Texas, Louisiana, and Florida using high-throughput DNA sequencing. Standard population genetic statistics were calculated, and demographic parameters were estimated using a composite-likelihood approach. Taxodium distichum in North America can be divided into at least three genetic groups, bald cypress in the MRAV and Texas, bald cypress in Florida, and pond cypress in Florida. The levels of genetic differentiation among the groups were low but significant. Several loci showed the signatures of positive selection, which might be responsible for local adaptation or varietal differentiation. Bald cypress was genetically differentiated into two geographical groups, and the boundary was located between the MRAV and Florida. This differentiation could be explained by population expansion from east to west. Despite the overlap of the two varieties' ranges, they were genetically differentiated in Florida. The estimated demographic parameters suggested that pond cypress split from bald cypress during the late Miocene. © 2016 Botanical Society of America.

  16. Socio-demographic factors and psychological distress in Indigenous and non-Indigenous Australian adults aged 18-64 years: analysis of national survey data

    Science.gov (United States)

    2012-01-01

    Background Indigenous Australians are known to be at greater risk of morbidity and mortality from mental health related conditions, but most available data relate to the use of mental health services, and little is known about other aspects of social and emotional wellbeing. Using the first available nationally representative data, we examined the prevalence and patterning of psychological distress among Indigenous Australian adults and compared these with corresponding data from the non-Indigenous population. Methods The analysis used weighted data on psychological distress, as measured by a modified Kessler Psychological Distress score (K5), and a range of socio-demographic measures for 5,417 Indigenous and 15,432 non-Indigenous adults aged 18-64 years from two nationally representative surveys. Very high psychological distress (VHPD) was defined as a K5 score ≥ 15 (possible range = 5-25). Results Indigenous adults were about three times more likely than non-Indigenous adults to be classified with VHPD: 14.5% (95% confidence interval (CI) 12.9-16.0%) versus 5.5% (95% CI 5.0-5.9%). After adjusting for age, most socio-demographic variables were significantly associated with VHPD in both populations, although the relative odds were generally larger among non-Indigenous people. Indigenous people in remote areas had a lower prevalence of VHPD than their non-remote counterparts, and only marital status, main language, and food insecurity were significantly associated with VHPD in remote areas. Conclusions Higher absolute levels of VHPD combined with smaller socio-demographic gradients in the Indigenous population suggest the importance of risk factors such as interpersonal racism, marginalization and dispossession, chronic stress and exposure to violence that are experienced by Indigenous Australians with common and/or cross-cutting effects across the socioeconomic spectrum. The lower prevalence of VHPD and lack of association with many socio-demographic variables in

  17. Socio-demographic factors and psychological distress in Indigenous and non-Indigenous Australian adults aged 18-64 years: analysis of national survey data.

    Science.gov (United States)

    Cunningham, Joan; Paradies, Yin C

    2012-02-01

    Indigenous Australians are known to be at greater risk of morbidity and mortality from mental health related conditions, but most available data relate to the use of mental health services, and little is known about other aspects of social and emotional wellbeing. Using the first available nationally representative data, we examined the prevalence and patterning of psychological distress among Indigenous Australian adults and compared these with corresponding data from the non-Indigenous population. The analysis used weighted data on psychological distress, as measured by a modified Kessler Psychological Distress score (K5), and a range of socio-demographic measures for 5,417 Indigenous and 15,432 non-Indigenous adults aged 18-64 years from two nationally representative surveys. Very high psychological distress (VHPD) was defined as a K5 score ≥ 15 (possible range = 5-25). Indigenous adults were about three times more likely than non-Indigenous adults to be classified with VHPD: 14.5% (95% confidence interval (CI) 12.9-16.0%) versus 5.5% (95% CI 5.0-5.9%). After adjusting for age, most socio-demographic variables were significantly associated with VHPD in both populations, although the relative odds were generally larger among non-Indigenous people. Indigenous people in remote areas had a lower prevalence of VHPD than their non-remote counterparts, and only marital status, main language, and food insecurity were significantly associated with VHPD in remote areas. Higher absolute levels of VHPD combined with smaller socio-demographic gradients in the Indigenous population suggest the importance of risk factors such as interpersonal racism, marginalization and dispossession, chronic stress and exposure to violence that are experienced by Indigenous Australians with common and/or cross-cutting effects across the socioeconomic spectrum. The lower prevalence of VHPD and lack of association with many socio-demographic variables in remote areas suggests either that the

  18. Breastfeeding practices and child growth outcomes in Haiti: an analysis of data from Demographic and Health Surveys.

    Science.gov (United States)

    Heidkamp, Rebecca; Ayoya, Mohamed Ag; Teta, Ismael Ngnie; Stoltzfus, Rebecca J; Marhone, Joseline Pierre

    2015-10-01

    Haiti's national nutrition policy prioritises breastfeeding, but limited data are available to inform strategy. We examined national trends in early initiation of breastfeeding (ErIBF) and exclusive breastfeeding (EBF) over a 10-year period using data from three Haitian Demographic and Health Surveys (1994-1995, 2000 and 2005-2006). We used multivariate regression methods to identify determinants of ErIBF and EBF in the 2005-2006 data set and to examine relationships to growth. There was no change in ErIBF across surveys [1994-1995: 36.6%, 95% confidence interval (CI) 29.9-43.9; 2000: 49.4%, 95% CI 44.1-54.8; 2005-2006: 43.8%, 95% CI 40.5-47.1]. EBF among 0-5-month-olds increased sharply (1994-18995: 1.1%, 95% CI 0.4-3.2; 2000: 22.4%, 95% CI 16.5-29.5; 2005-2006: 41.2%, 95% CI 35.4-47.2). The proportion of breastfeeding children 0-5 months who received soft, solid or semi-solid foods decreased (1994-1995: 68.5%, 95% CI 57.3-77.9; 2000: 46.3%, 95% CI 39.3-53.4; 2005-2006: 30.9%, 95% CI 25.9-36.5). Child age at time of survey [odds ratio (OR) 1.73; P = 0.027], lower maternal education (OR = 2.14, P = 0.004) and residence in the Artibonite Department (OR 0.31; P = 0.001) were associated with ErIBF among children 0-23 months. Age group and department were significant predictors of EBF among children 0-5 months. ErIBF was associated with higher weight-for-age z-scores [effect size (ES) 0.22; P = 0.033] and height-for-age z-scores (ES 0.20; P = 0.044). There was no statistically significant relationship between EBF and growth. The 10-year ErIBF and EBF trends in Haiti echo global and regional trends. ErIBF and EBF are related practices but with different determinants in the Haitian context. These differences have implications for intervention delivery.

  19. Association between Measures of Women's Empowerment and Use of Modern Contraceptives: An Analysis of Nigeria's Demographic and Health Surveys.

    Science.gov (United States)

    Asaolu, Ibitola O; Okafor, Chioma T; Ehiri, Jennifer C; Dreifuss, Heather M; Ehiri, John E

    2016-01-01

    Women's empowerment is hypothesized as a predictor of reproductive health outcomes. It is believed that empowered girls and women are more likely to delay marriage, plan their pregnancies, receive prenatal care, and have their childbirth attended by a skilled health provider. The objective of this study was to assess the association between women's empowerment and use of modern contraception among a representative sample of Nigerian women. This study used the 2003, 2008, and 2013 Nigeria Demographic and Health Survey data. The analytic sample was restricted to 35,633 women who expressed no desire to have children within 2 years following each survey, were undecided about timing for children, and who reported no desire for more children. Measures of women's empowerment included their ability to partake in decisions pertaining to their healthcare, large household purchases, and visit to their family or relatives. Multivariable regression models adjusting for respondent's age at first birth, religion, education, wealth status, number of children, and geopolitical region were used to measure the association between empowerment and use of modern contraceptives. The proportion of women who participated in decisions to visit their relatives increased from 42.5% in 2003 to 50.6% in 2013. The prevalence of women involved in decision-making related to large household purchases increased from 24.3% in 2003 to 41.1% in 2013, while the proportion of those who partook in decision related to their health care increased from 28.4% in 2003 to 41.9% in 2013. Use of modern contraception was positively associated with women's participation in decisions related to large household purchases [2008: adjusted OR (aOR) = 1.15; 95% CI = 1.01-1.31] and (2013; aOR = 1.60; 1.40-1.83), health care [2008: (aOR = 1.20; 1.04-1.39) and (2013; aOR = 1.39; 1.22-1.59)], and visiting family or relatives [2013; aOR = 1.58; 1.36-1.83]. The prevalence of modern contraceptive use

  20. An analysis of pregnancy-related mortality in the KEMRI/CDC health and demographic surveillance system in western Kenya.

    Directory of Open Access Journals (Sweden)

    Meghna Desai

    Full Text Available BACKGROUND: Pregnancy-related (PR deaths are often a result of direct obstetric complications occurring at childbirth. METHODS AND FINDINGS: To estimate the burden of and characterize risk factors for PR mortality, we evaluated deaths that occurred between 2003 and 2008 among women of childbearing age (15 to 49 years using Health and Demographic Surveillance System data in rural western Kenya. WHO ICD definition of PR mortality was used: "the death of a woman while pregnant or within 42 days of termination of pregnancy, irrespective of the cause of death". In addition, symptoms and events at the time of death were examined using the WHO verbal autopsy methodology. Deaths were categorized as either (i directly PR: main cause of death was ascribed as obstetric, or (ii indirectly PR: main cause of death was non-obstetric. Of 3,223 deaths in women 15 to 49 years, 249 (7.7% were PR. One-third (34% of these were due to direct obstetric causes, predominantly postpartum hemorrhage, abortion complications and puerperal sepsis. Two-thirds were indirect; three-quarters were attributable to human immunodeficiency virus (HIV/AIDS, malaria and tuberculosis. Significantly more women who died in lower socio-economic groups sought care from traditional birth attendants (p = 0.034, while less impoverished women were more likely to seek hospital care (p = 0.001. The PR mortality ratio over the six years was 740 (95% CI 651-838 per 100,000 live births, with no evidence of reduction over time (χ(2 linear trend = 1.07; p = 0.3. CONCLUSIONS: These data supplement current scanty information on the relationship between infectious diseases and poor maternal outcomes in Africa. They indicate low uptake of maternal health interventions in women dying during pregnancy and postpartum, suggesting improved access to and increased uptake of skilled obstetric care, as well as preventive measures against HIV/AIDS, malaria and tuberculosis among all women of childbearing age may

  1. Show Time

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    <正> Story: Show Time!The whole class presents the story"Under the Sea".Everyone is so excited and happy.Both Leo and Kathy show their parentsthe characters of the play."Who’s he?"asks Kathy’s mom."He’s the prince."Kathy replies."Who’s she?"asks Leo’s dad."She’s the queen."Leo replieswith a smile.

  2. Snobbish Show

    Institute of Scientific and Technical Information of China (English)

    YIN PUMIN

    2010-01-01

    @@ The State Administration of Radio,Film and Television (SARFT),China's media watchdog,issued a new set of mles on June 9 that strictly regulate TV match-making shows,which have been sweeping the country's primetime programming. "Improper social and love values such as money worship should not be presented in these shows.Humiliation,verbal attacks and sex-implied vulgar content are not allowed" the new roles said.

  3. Demographic and socioeconomic inequalities in the risk of emergency hospital admission for violence: cross-sectional analysis of a national database in Wales

    Science.gov (United States)

    Fone, David; Gartner, Andrea; Bellis, Mark A

    2016-01-01

    Objectives To investigate the risk of emergency hospital admissions for violence (EHAV) associated with demographic and socioeconomic factors in Wales between 2007/2008 and 2013/2014, and to describe the site of injury causing admission. Design Database analysis of 7 years’ hospital admissions using the Patient Episode Database for Wales (PEDW). Setting and participants Wales, UK, successive annual populations ∼2.8 million aged 0–74 years. Primary outcome The first emergency admission for violence in each year of the study, defined by the International Classification of Diseases V.10 (ICD-10) codes for assaults (X85-X99, Y00-Y09) in any coding position. Results A total of 11 033 admissions for assault. The majority of admissions resulted from head injuries. The overall crude admission rate declined over the study period, from 69.9 per 100 000 to 43.2 per 100 000, with the largest decrease in the most deprived quintile of deprivation. A generalised linear count model with a negative binomial log link, adjusted for year, age group, gender, deprivation quintile and settlement type, showed the relative risk was highest in age group 18–19 years (RR=6.75, 95% CI 5.88 to 7.75) compared with the reference category aged 10–14 years. The risk decreased with age after 25 years. Risk of admission was substantially higher in males (RR=4.55, 95% CI 4.31 to 4.81), for residents of the most deprived areas of Wales (RR=3.60, 95% CI 3.32 to 3.90) compared with the least deprived, and higher in cities (RR=1.37, 95% CI 1.27 to 1.49) and towns (RR=1.32, 95% CI 1.21 to 1.45) compared with villages. Conclusions Despite identifying a narrowing in the gap between prevalence of violence in richer and poorer communities, violence remains strongly associated with young men living in areas of socioeconomic deprivation. There is potential for a greater reduction, given that violence is mostly preventable. Recommendations for reducing inequalities in the risk of

  4. Demographic and socioeconomic inequalities in the risk of emergency hospital admission for violence: cross-sectional analysis of a national database in Wales.

    Science.gov (United States)

    Long, Sara Jayne; Fone, David; Gartner, Andrea; Bellis, Mark A

    2016-08-24

    To investigate the risk of emergency hospital admissions for violence (EHAV) associated with demographic and socioeconomic factors in Wales between 2007/2008 and 2013/2014, and to describe the site of injury causing admission. Database analysis of 7 years' hospital admissions using the Patient Episode Database for Wales (PEDW). Wales, UK, successive annual populations ∼2.8 million aged 0-74 years. The first emergency admission for violence in each year of the study, defined by the International Classification of Diseases V.10 (ICD-10) codes for assaults (X85-X99, Y00-Y09) in any coding position. A total of 11 033 admissions for assault. The majority of admissions resulted from head injuries. The overall crude admission rate declined over the study period, from 69.9 per 100 000 to 43.2 per 100 000, with the largest decrease in the most deprived quintile of deprivation. A generalised linear count model with a negative binomial log link, adjusted for year, age group, gender, deprivation quintile and settlement type, showed the relative risk was highest in age group 18-19 years (RR=6.75, 95% CI 5.88 to 7.75) compared with the reference category aged 10-14 years. The risk decreased with age after 25 years. Risk of admission was substantially higher in males (RR=4.55, 95% CI 4.31 to 4.81), for residents of the most deprived areas of Wales (RR=3.60, 95% CI 3.32 to 3.90) compared with the least deprived, and higher in cities (RR=1.37, 95% CI 1.27 to 1.49) and towns (RR=1.32, 95% CI 1.21 to 1.45) compared with villages. Despite identifying a narrowing in the gap between prevalence of violence in richer and poorer communities, violence remains strongly associated with young men living in areas of socioeconomic deprivation. There is potential for a greater reduction, given that violence is mostly preventable. Recommendations for reducing inequalities in the risk of admission for violence are discussed. Published by the BMJ Publishing Group Limited. For

  5. Laboratory Demographics Lookup Tool

    Data.gov (United States)

    U.S. Department of Health & Human Services — This website provides demographic information about laboratories, including CLIA number, facility name and address, where the laboratory testing is performed, the...

  6. RiskDiff: a web tool for the analysis of the difference due to risk and demographic factors for incidence or mortality data

    Science.gov (United States)

    2009-01-01

    Background Analysing the observed differences for incidence or mortality of a particular disease between two different situations (such as time points, geographical areas, gender or other social characteristics) can be useful both for scientific or administrative purposes. From an epidemiological and public health point of view, it is of great interest to assess the effect of demographic factors in these observed differences in order to elucidate the effect of the risk of developing a disease or dying from it. The method proposed by Bashir and Estève, which splits the observed variation into three components: risk, population structure and population size is a common choice at practice. Results A web-based application, called RiskDiff has been implemented (available at http://rht.iconcologia.net/riskdiff.htm), to perform this kind of statistical analyses, providing text and graphical summaries. Code from the implemented functions in R is also provided. An application to cancer mortality data from Catalonia is used for illustration. Conclusions Combining epidemiological with demographical factors is crucial for analysing incidence or mortality from a disease, especially if the population pyramids show substantial differences. The tool implemented may serve to promote and divulgate the use of this method to give advice for epidemiologic interpretation and decision making in public health. PMID:20021655

  7. EROBATIC SHOW

    Institute of Scientific and Technical Information of China (English)

    2016-01-01

    Visitors look at plane models of the Commercial Aircraft Corp. of China, developer of the count,s first homegrown large passenger jet C919, during the Singapore Airshow on February 16. The biennial event is the largest airshow in Asia and one of the most important aviation and defense shows worldwide. A number of Chinese companies took part in the event during which Okay Airways, the first privately owned aidine in China, signed a deal to acquire 12 Boeing 737 jets.

  8. [Integration of demographic variables into development plans in the Sahel].

    Science.gov (United States)

    Wane, H R

    1992-07-01

    A founding principle of the Program of Action of N'Djamena is the interdependence of population and development and the need for development strategies to take demographic factors into account. The concept of integration of population variables into development has evolved since its introduction in the 1974 World Population Plan of Action from a simple description of population size, growth rates, and distribution to a stress on harmonizing population policies and development policies with macroeconomic variables. The essence of the concept is the consideration given by development policies and programs to the interrelations between population, resources, the environment, and development factors. Population variables and goals should ideally be treated as endogenous variables in development planning, but in practice the extreme complexity of such a systematic approach limits its ability to be made operational. Usually the most crucial problems only are included. Integrated planning is composed of explicit or implicit population policies intended to influence demographic variables and of socioeconomic policies intended to adapt to demographic change. In the Sahel, only Senegal, Burkina Faso, and Mali have formal population policies, but around 1980 several countries of the region began to show interest in influencing demographic variables as they did economic variables. Fundamental principles for developing an integration strategy can be applied regardless or whether the plan is based on projections, analysis of interaction of a demographic variable with factors specific to a sector, or a monosectorial or multisectorial demoeconomic planning model. Demographic data is used more frequently in diagnosing problems than in developing projections or formulating objectives. The level of disaggregation of demographic projections and estimates tends to be low, despite the great potential utility of demographic projections in planning. Demographic projections can be useful

  9. Democratic constraints on demographic policy.

    Science.gov (United States)

    Grigsby, J S

    1984-01-01

    purpose of making policy recommendations aimed directly at mitigating demographic problems. As demographic goals have little meaning outside of a broader context, it comes as no surprise that the population commissions of Sweden and the US broadened their scope of analysis to include social issues that extended beyond simply demographic problems themselves. To be effective, population commissions should be seen as a basis for making well thought out policy recommendations for solving concrete economic or social problems. The population commission can also be regarded as an educational forum for researchers, the government, and the public.

  10. [Skeletochronological determination of age and demographic analysis of a population of Acanthodactylus pardalis (Lischenstein, 1823) of the Kerkennah islands (Tunisia)].

    Science.gov (United States)

    Nouira, S

    1987-07-01

    The skeletochronological analysis of 34 adult lizards from population of Acanthodactylus pardalis of Kerkennah islands in Tunisia enabled to: determine the individual age of the animals; delineate four various cohorts making up the studied population; evaluate around 4 years life span in nature of this species; point out that the renewal rate accounts for 41% of its population. Moreover the method of "maximums successifs" is applied on sizeable sample in order to shore up the obtained results.

  11. Meta-Analysis of the Effects of Puppet Shows on Attitudes toward and Knowledge of Individuals with Disabilities

    Science.gov (United States)

    Dunst, Carl J.

    2014-01-01

    Findings from a meta-analysis of 26 studies investigating the effects of either the "Kids on the Block" or "Count Me In" puppet shows on changes in elementary students' attitudes toward and knowledge of individuals with disabilities are reported. The studies included 5,302 intervention group participants and 2,642…

  12. A Demographic Perspective on Family Change

    Science.gov (United States)

    Bianchi, Suzanne M.

    2014-01-01

    Demographic analysis seeks to understand how individual microlevel decisions about child-bearing, marriage and partnering, geographic mobility, and behaviors that influence health and longevity aggregate to macrolevel population trends and differentials in fertility, mortality and migration. In this review, I first discuss theoretical perspectives—classic demographic transition theory, the perspective of the “second demographic transition,” the spread of developmental idealism—that inform demographers’ understanding of macrolevel population change. Then, I turn to a discussion of the role that demographically informed data collection has played in illuminating family change since the mid-20th century in the United States. Finally, I discuss ways in which demographic theory and data collection might inform future areas of family research, particularly in the area of intergenerational family relationships and new and emerging family forms. PMID:26078785

  13. Demographic Composition of the Online Buyers in Turkey

    Directory of Open Access Journals (Sweden)

    Sinan NARDALI

    2011-06-01

    Full Text Available Demographic variables may have an impact on Internet usage patterns. Online buyers’ characteristics keeps changing time along with the shifting dynamics of Turkish consumers’ demographic profile and day by day online shopping becomes a safe and popular option in Turkey. Current study investigates demographic composition of the online buyers that influence consumer attitudes towards online shopping behavior in Izmir, the third largest city in Turkey. This study examines attitudes toward online shopping and provides a better understanding of the potential of online buyers for both researchers and practitioners. The study is based on an empirical research work, and a convenience sample of 400. Frequencies, descriptive statistics, and One-Way ANOVA tests were used in the analysis of data. The study shows that Turkish Internet consumer segment is relatively young, well educated, in mid economic status and professions associated with Internet more than five years.

  14. Socio-Demographic Factors Related to Oral Cancer

    Directory of Open Access Journals (Sweden)

    Abdoul Hossain Madani

    2010-01-01

    Full Text Available Problem statement: The aim of this study was to identify factors related to cancer of oral cavity considering individual socio-demographic characteristics of a hospital based study in Pune. Approach: A case-control study was conducted. The cases were 350 with squamous-cell carcinoma of oral cavity diagnosed between 2005 and 2006 in Morbai, Narandia, Budharani Cancer Institute, Pune, India. Similar number of controls matched for age and sex selected from the background population. Cases and controls were interviewed for general characteristics; age, gender, education and possible socio-demographic factors. Results: Chi-square test in uni-variate analysis and estimate for risk showed that education, occupation and monthly household income were significantly different between cases and controls (pConclusion/Recommendations: Socio-demographic factors such as education, occupation and income do play an important role in development oral cancer.

  15. A National Study Assessing the Teaching and Learning of Introductory Astronomy Part II: Analysis of Student Demographics

    Science.gov (United States)

    Rudolph, Alexander; Prather, E. E.; Brissenden, G.; Consiglio, D.; Gonzaga, V.

    2010-01-01

    This is the second in a series of reports on a national study of the teaching and learning of astronomy in general education, non-science major, introductory college astronomy courses (Astro 101). The results show dramatic improvement in student learning with increased use of interactive learning strategies even after controlling for individual student characteristics. In addition, we find that the positive effects of interactive learning strategies apply equally to men and women, across ethnicities, for students with all levels of prior mathematical preparation and physical science course experience, independent of GPA, and regardless of primary language. These results powerfully illustrate that all categories of students can benefit from the effective implementation of interactive learning strategies.

  16. [Inequities in health: socio-demographic and spatial analysis of breast cancer in women from Córdoba, Argentina].

    Science.gov (United States)

    Tumas, Natalia; Pou, Sonia Alejandra; Diaz, Maria Del Pilar

    2017-03-18

    To identify sociodemographic determinants associated with the spatial distribution of the breast cancer incidence in the province of Córdoba, Argentina, in order to reveal underlying social inequities. An ecological study was developed in Córdoba (26 counties as geographical units of analysis). The spatial autocorrelation of the crude and standardised incidence rates of breast cancer, and the sociodemographic indicators of urbanization, fertility and population ageing were estimated using Moran's index. These variables were entered into a Geographic Information System for mapping. Poisson multilevel regression models were adjusted, establishing the breast cancer incidence rates as the response variable, and by selecting sociodemographic indicators as covariables and the percentage of households with unmet basic needs as adjustment variables. In Córdoba, Argentina, a non-random pattern in the spatial distribution of breast cancer incidence rates and in certain sociodemographic indicators was found. The mean increase in annual urban population was inversely associated with breast cancer, whereas the proportion of households with unmet basic needs was directly associated with this cancer. Our results define social inequity scenarios that partially explain the geographical differentials in the breast cancer burden in Córdoba, Argentina. Women residing in socioeconomically disadvantaged households and in less urbanized areas merit special attention in future studies and in breast cancer public health activities. Copyright © 2017 SESPAS. Publicado por Elsevier España, S.L.U. All rights reserved.

  17. Socio-demographic analysis of status and level of nutrition and physical activity in two schools in Granada (Spain.

    Directory of Open Access Journals (Sweden)

    María I. Tovar-Galvez

    2017-04-01

    Full Text Available Objectives: Currently, nutritional habits and the lifestyle of Spanish schoolchildren have undergone important changes. This study aimed to analyze the sociodemographic characteristics, eating habits and physical activity of schoolchildren of two different schools and determine possible differences in nutritional status and body composition, as well as nutrition and physical activity level of school children. Methods: Cross-sectional study of 114 schoolchildren between 8 and 13 years old, from Granada, Spain. An assessment of the nutritional status was performed by anthropometry and an analysis of body composition by bioelectrical impedance. Two questionnaires were used, one ad hoc about sociodemographic and nutritional data and the Krece-Plus test to assess nutritional status and physical activity. Results: There are no noteworthy significant differences in the nutritional habits of schoolchildren in both centers, most performed five daily meals. There are significant differences in the use of transport to go to school; schoolchildren of the Albayzín attend to school walking everyday, with a higher prevalence of low weight and ideal fat percentage lower than recommended. On the other hand, the schoolchildren in the center of the capital have low regular physical activity and nutritional status. There are sociodemographic differences between the two populations of students, both comply with the recommendations on the number of daily intakes. Conclusion: Students who reside in the center of Granada are more sedentary than their counterparts in the Albayzín and have a higher prevalence of overweight and obesity. Students of the Albayzín have better nutrition and physical activity level.

  18. Demographic Change and Transport

    DEFF Research Database (Denmark)

    Haustein, Sonja; Siren, Anu Kristiina; Framke, Elisabeth

    This report is the literature review on demographic changes and transport of Work Package 1 of the EU project CONSOL, “CONcerns and SOLutions – Road Safety in the Ageing Societies” (contract period: 2011-2013). The report is a state-of-the art report that combines current knowledge with new findi...

  19. Genetically Engineered Ricin Suppresses Bactrocera dorsalis (Diptera: Tephritidae) based on Demographic Analysis of Group-Reared Life Table.

    Science.gov (United States)

    Chang, Cheng; Huang, Chun-Yen; Dai, Shu-Mei; Atlihan, Remzi; Chi, Hsin

    2016-04-27

    The oriental fruit fly, Bactrocera dorsalis (Hendel), reduces the quantity and quality of many host fruits through the process of oviposition and larval feeding, and this insect has been considered a major insect pest in several Asian countries for decades. Using an earlier-developed, female-specific system that combines the toxicity of the ricin A chain (RTA) and the alternative RNA splicing property of doublesex (Bddsx), we show that transgenic male flies harboring the RTA-Bddsx transgene unevenly repress the pest population through inheritable effects. In age-stage, two-sex life-table analyses, high larval mortality and a delay in pupation were observed after introducing the transgene. The high male to female ratio in DsRed(+) flies demonstrates the lethal effect of ricin on females. The fitness of both the DsRed(+)- and DsRed(-)-transformed females was reduced as shown in the decrease of the net reproductive rate (R0), intrinsic rate (r), and finite rate (λ) values compared with the wild-type populations. The integrity of the RTA-Bddsx transgene remained in more than 80% of DsRed(+) males after ten generations, supporting the stable inheritance of the transgene. All of the data from this study support the proposed RTA-Bddsx SIT approach, which provides a species-specific and environmentally friendly method of suppressing, rather than eradiating, B. dorsalis. © The Authors 2016. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  20. Epidemiological analysis of demographic characteristics and type of injuries in patients with multiple trauma with respect to conclusive treatment outcome

    Directory of Open Access Journals (Sweden)

    Zagorac Slaviša

    2008-01-01

    Full Text Available Introduction Multiple trauma is one of the leading causes of mortality and morbidity in the population of people under 45 years of age. The consequences of multiple trauma have huge epidemiological, social and economic significance. Objective The aim of the paper was to analyze the conclusive treatment outcome of multiply traumatized patients with respect to their sex, age, injury mechanism and type. METHOD This retrospective study included 100 patients with multiple injuries (ISS>16 treated in the Emergency Room of the Clinical Centre of Serbia in the course of 2004. Clinical, X-ray, laboratory and numerical presentation methods - scores (ISS and GCS were used to show the injury severity. Results Most of the injured were males (80%, and the average age was 40±20 (5-83. Out of the total number of patients who died, 23 (82% were males, and 5 (18% were females. The average age of the patients with fatal outcomes was 48±21 (8-86. Traffic accidents were the leading cause of injury (59%. The median GCS was 10±3 (3-15. The average ISS was 30 (20-66 in the surviving patients, and 53 (27-77 in those who died. Conclusion With respect to sex, in most cases multiple trauma affects males (p<0.01, with the average age of about 40. With respect to injury mechanism, the main cause of the occurrence of multiple trauma is traffic accidents (p<0.01. There is a statistically significant difference in the values of GCS and ISS relative to the definitive outcome (p<0.01. Statistical data processing indicated that there was a statistically significant correlation between mortality and type of injury in a given organic system (p<0.01, but that there was no statistically significant correlation between mortality and age. .

  1. Handwashing in 51 Countries: Analysis of Proxy Measures of Handwashing Behavior in Multiple Indicator Cluster Surveys and Demographic and Health Surveys, 2010-2013.

    Science.gov (United States)

    Kumar, Swapna; Loughnan, Libbet; Luyendijk, Rolf; Hernandez, Orlando; Weinger, Merri; Arnold, Fred; Ram, Pavani K

    2017-08-01

    In 2009, a common set of questions addressing handwashing behavior was introduced into nationally representative Demographic and Health Surveys (DHS) and Multiple Indicator Cluster Surveys (MICS), providing large amounts of comparable data from numerous countries worldwide. The objective of this analysis is to describe global handwashing patterns using two proxy indicators for handwashing behavior from 51 DHS and MICS surveys conducted in 2010-2013: availability of soap anywhere in the dwelling and access to a handwashing place with soap and water. Data were also examined across geographic regions, wealth quintiles, and rural versus urban settings. We found large disparities for both indicators across regions, and even among countries within the same World Health Organization region. Within countries, households in lower wealth quintiles and in rural areas were less likely to have soap anywhere in the dwelling and at designated handwashing locations than households in higher wealth quintiles and urban areas. In addition, disparities existed among various geographic regions within countries. This analysis demonstrates the need to promote access to handwashing materials and placement at handwashing locations in the dwelling, particularly in poorer, rural areas where children are more vulnerable to handwashing-preventable syndromes such as pneumonia and diarrhea.

  2. SHOW. A program for the integrated analysis of the data produced in a nuclear fusion experimental device

    Energy Technology Data Exchange (ETDEWEB)

    Bracco, G.; Tudisco, O. [ENEA, Centro Ricerche Casaccia, Rome (Italy). Dipt. Energia

    1998-03-01

    The report describes the program SHOW, an application devoted to the integrated analysis of the data produced in nuclear fusion experimental devices. The program is currently used for the analysis of the FTU data and a version is also available at JET. The code is written in FORTRAN 77, runs on IBM mainframes under MVS operating system and makes use of the GDDM graphical package. The program, that operates both in batch and interactive modes, permits to perform a graphical analysis of the data collected in the experimental databases. The report contains as appendixes the detailed description of all the program options together with a short illustration of the FTU databases. [Italiano] Il rapporto descrive il programma SHOW. Si tratta di una applicazione che permette l`analisi integrata dei dati prodotti da apparati sperimentali dedicati allo studio della fusione nucleare controllata. Il programma e` utilizzato per l`analisi dei dati di FTU (Frascati Tokamak Upgrade) e una versione e` disponibile anche al JET (Joint European Torus). Il codice e` scritto in FORTRAN 77 per mainframes IBM con sistema operativo MVS ed utilizza il pacchetto grafico GDDM. Il programma puo` funzionare sia in modo batch che in modo interattivo e permette di compiere l`elaborazione grafica dei dati raccolti nelle basi di dati sperimentali. Il rapporto contiene come appendici la descrizione dettagliata di tutte le opzioni del programma e una breve illustrazione delle basi di dati disponibili per FTU.

  3. Understanding the relationship between access to care and facility-based delivery through analysis of the 2008 Ghana Demographic Health Survey.

    Science.gov (United States)

    Moyer, Cheryl A; McLaren, Zoë M; Adanu, Richard M; Lantz, Paula M

    2013-09-01

    To determine the types of access to care most strongly associated with facility-based delivery among women in Ghana. Data relating to the "5 As of Access" framework were extracted from the 2008 Ghana Demographic Health Survey and analyzed using multivariate logistic regression. In all, 55.5% of a weighted sample of 1102 women delivered in a healthcare facility, whereas 45.5% delivered at home. Affordability was the strongest access factor associated with delivery location, with health insurance coverage tripling the odds of facility delivery. Availability, accessibility (except urban residence), acceptability, and social access variables were not significant factors in the final models. Social access variables, including needing permission to seek healthcare and not being involved in decisions regarding healthcare, were associated with a reduced likelihood of facility-based delivery when examined individually. Multivariate analysis suggested that these variables reflected maternal literacy, health insurance coverage, and household wealth, all of which attenuated the effects of social access. Affordability was an important determinant of facility delivery in Ghana-even among women with health insurance-but social access variables had a mediating role. Copyright © 2013 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.

  4. The impact of clinical, demographic and risk factors on rates of HIV transmission: a population-based phylogenetic analysis in British Columbia, Canada.

    Science.gov (United States)

    Poon, Art F Y; Joy, Jeffrey B; Woods, Conan K; Shurgold, Susan; Colley, Guillaume; Brumme, Chanson J; Hogg, Robert S; Montaner, Julio S G; Harrigan, P Richard

    2015-03-15

    The diversification of human immunodeficiency virus (HIV) is shaped by its transmission history. We therefore used a population based province wide HIV drug resistance database in British Columbia (BC), Canada, to evaluate the impact of clinical, demographic, and behavioral factors on rates of HIV transmission. We reconstructed molecular phylogenies from 27,296 anonymized bulk HIV pol sequences representing 7747 individuals in BC-about half the estimated HIV prevalence in BC. Infections were grouped into clusters based on phylogenetic distances, as a proxy for variation in transmission rates. Rates of cluster expansion were reconstructed from estimated dates of HIV seroconversion. Our criteria grouped 4431 individuals into 744 clusters largely separated with respect to risk factors, including large established clusters predominated by injection drug users and more-recently emerging clusters comprising men who have sex with men. The mean log10 viral load of an individual's phylogenetic neighborhood (composed of 5 other individuals with shortest phylogenetic distances) increased their odds of appearing in a cluster by >2-fold per log10 viruses per milliliter. Hotspots of ongoing HIV transmission can be characterized in near real time by the secondary analysis of HIV resistance genotypes, providing an important potential resource for targeting public health initiatives for HIV prevention. © The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  5. Effects of planned, mistimed and unwanted pregnancies on the use of prenatal health services in sub-Saharan Africa: a multicountry analysis of Demographic and Health Survey data.

    Science.gov (United States)

    Amo-Adjei, Joshua; Anamaale Tuoyire, Derek

    2016-12-01

    We analysed the extent of planned, mistimed and unwanted pregnancies and how they predict optimal use of prenatal (timing and number of antenatal) care services in 30 African countries. We pooled data from Demographic and Health Surveys conducted in 30 African countries between 2006 and 2015. We described the extent of mistimed and unwanted pregnancies and further used mixed effects logistic and Poisson regression estimation techniques to examine the impacts of planned, mistimed and unwanted pregnancies on the use of prenatal health services. In total, 73.65% of pregnancies in all countries were planned. Mistimed pregnancy ranged from 7.43% in Burkina Faso to 41.33% in Namibia. Unwanted pregnancies were most common in Swaziland (39.54%) and least common in Niger (0.74%). Timely (first trimester) initiation of ANC was 37% overall in all countries; the multicountry average number of ANC visits was optimal [4.1; 95% CI: 4.1-4.2] but with notable disparities between countries. Overall, mistimed and unwanted pregnancies were strongly associated with late ANC attendance and fewer visits women made in the pooled analysis. Unintended pregnancies are critical risks to achieving improved maternal health in respect of early and optimal ANC coverage for women in Africa. Programmes targeted at advancing coverage of ANC in Africa need to deploy contextually appropriate mechanisms to prevent unintended pregnancies. © 2016 John Wiley & Sons Ltd.

  6. Demographic Analysis on Mobile Communication Traffic Difference in China%我国移动通信量差异的人口学分析

    Institute of Scientific and Technical Information of China (English)

    王思思; 张秋娈; 路紫; 段禅

    2012-01-01

    引人了地理迁移关系模型和社会网络人类动力学模型,将前一个模型中的“1个原型网络系统和2个变形网络系统”转换为演变过程的原始状态、迁移及适应3个阶段,将后一个模型中的“社会网络的典型特征——较高的集聚和较短的平均路径”分解为2个类型(非群体类型和群体类型),作为我国移动通信量人口学分析的研究方法.构建了我国各省的包括3个人口迁移指标、4个人口技术构成指标在内的人口学数据系统,针对3个重要的移动通信指标,分别解释人口学要素与移动通信量的内在联系.研究发现:1)应用地理迁移关系模型可以较好地描述不同演变阶段人口迁移对移动通信使用的影响,这种影响是通过保持原有链接、构建产生新链接而完成的;2)应用社会网络人类动力学模型可以较好地描述人口技术构成因素对移动通信使用的影响.%Geographical migration relationship model and human dynamics model of social network are introduced, "an original network system and two transforming network system" of the former model is shifted to an evolutional process of aboriginally, migration and adaption; "the typical characteristic of social network-higher aggregation and shorter average path length" of the latter model is disintegrated to two types (group type and non group type). These two modles are taken as research method of demographic analysis on mobile communication. The demographic data consists of three population migration indices and four population technical composition indices of provinces in China which against three important mobile communication indices are built to explain the internal relation between demographic factors and mobile communication traffic respectively. The research findings are:geographical migration relationship model has a better performance for describing the impact of population migration in different evolutional stages on

  7. Pioneer 10 and 11 orbit determination analysis shows no discrepancy with Newton-Einstein's laws of gravity

    CERN Document Server

    Modenini, Dario

    2013-01-01

    The present work describes the investigation of the navigation anomaly of Pioneer 10 and 11 probes which became known as the Pioneer Anomaly. It appeared as a linear drift in the Doppler data received by the spacecraft, which has been ascribed to an approximately constant sunward acceleration of about $8.5 \\times 10^{-13} km/s^2$. Since then, the existence of the anomaly has been confirmed independently by several groups and a large effort was devoted to find its origin. The present study consists of two main parts: thermal modeling of the spacecraft throughout its trajectory, and orbit determination analysis. Based on existing documentation and published telemetry data we built a thermal finite element model of the spacecraft, whose complexity has been constrained to a degree allowing for sensitivity analysis, leading to the computation of its formal uncertainty. The trajectory analysis and orbit determination was carried out using NASA/JPL's ODP (Orbit Determination Program) and our results show that orbita...

  8. Pioneer 10 and 11 orbit determination analysis shows no discrepancy with Newton-Einstein laws of gravity

    Science.gov (United States)

    Modenini, D.; Tortora, P.

    2014-07-01

    The present work describes our investigation of the navigation anomaly of the Pioneer 10 and 11 probes which became known as the Pioneer Anomaly. It appeared as a linear drift in the Doppler data received by the spacecraft, which has been ascribed to an approximately constant Sunward acceleration of about 8.5×10-13 km/s2. Since then, the existence of the anomaly has been confirmed independently by several groups and a large effort was devoted to find its origin. Recently, different analyses were published where the authors claimed the acceleration due to anisotropic thermal emission to be the most likely cause of the unexplained acceleration. Here we report the methodology and the results of an independent study carried out in the last years, aimed at supporting the thermal origin of the anomaly. This work consists of two main parts: thermal modeling of the spacecraft throughout its trajectory, and orbit determination analysis. Based on existing documentation and published telemetry data, we built a thermal finite element model of the spacecraft, whose complexity has been constrained to a degree allowing for sensitivity analysis, leading to the computation of its formal uncertainty. The trajectory analysis and orbit determination were carried out using NASA/JPL's Orbit Determination Program, and our results show that orbital solutions are achieved that do not require the addition of any "unknown" acceleration other than that of thermal origin.

  9. Chronological objects in demographic research

    Directory of Open Access Journals (Sweden)

    Frans J. Willekens

    2013-03-01

    Full Text Available BACKGROUND Calendar time, age and duration are chronological objects. They represent an instant or a time period. Age and duration are usually expressed in units with varying lengths. The number of days in a month or a year depends on the position on the calendar. The units are also not homogeneous and the structure influences measurement. One solution, common in demography, is to use units that are large enough for the results not to be seriously affected by differences in length and structure. Another approach is to take the idiosyncrasy of calendars into account and to work directly with calendar dates. The technology that enables logical and arithmetic operations on dates is available. OBJECTIVE To illustrate logical and arithmetic operations on dates and conversions between time measurements. METHODS Software packages include utilities to process dates. I use existing and a few new utilities in R to illustrate operations on dates and conversions between calendar dates and elapsed time since a reference moment or a reference event. Three demographic applications are presented. The first is the impact of preferences for dates and days on demographic indicators. The second is event history analysis with time-varying covariates. The third is microsimulation of life histories in continuous time. CONCLUSIONS The technology exists to perform operations directly on dates, enabling more precise calculations of duration and elapsed time in demographic analysis. It eliminates the need for (a approximations and (b transformations of dates, such as Century Month Code, that are convenient for computing durations but are a barrier to interpretation. Operations on dates, such as the computation of age, should consider time units of varying length.

  10. Who theorizes age? The "socio-demographic variables" device and age-period-cohort analysis in the rhetoric of survey research.

    Science.gov (United States)

    Rughiniș, Cosima; Humă, Bogdana

    2015-12-01

    In this paper we argue that quantitative survey-based social research essentializes age, through specific rhetorical tools. We outline the device of 'socio-demographic variables' and we discuss its argumentative functions, looking at scientific survey-based analyses of adult scientific literacy, in the Public Understanding of Science research field. 'Socio-demographics' are virtually omnipresent in survey literature: they are, as a rule, used and discussed as bundles of independent variables, requiring little, if any, theoretical and measurement attention. 'Socio-demographics' are rhetorically effective through their common-sense richness of meaning and inferential power. We identify their main argumentation functions as 'structure building', 'pacification', and 'purification'. Socio-demographics are used to uphold causal vocabularies, supporting the transmutation of the descriptive statistical jargon of 'effects' and 'explained variance' into 'explanatory factors'. Age can also be studied statistically as a main variable of interest, through the age-period-cohort (APC) disambiguation technique. While this approach has generated interesting findings, it did not mitigate the reductionism that appears when treating age as a socio-demographic variable. By working with age as a 'socio-demographic variable', quantitative researchers convert it (inadvertently) into a quasi-biological feature, symmetrical, as regards analytical treatment, with pathogens in epidemiological research. Copyright © 2015 Elsevier Inc. All rights reserved.

  11. The eroticism of Internet cruising as a self-contained behaviour: a multivariate analysis of men seeking men demographics and getting off online.

    Science.gov (United States)

    Robinson, Brandon Andrew; Moskowitz, David A

    2013-01-01

    Most studies on men seeking men and who use the Internet for sexual purposes have focused on the epidemiological outcomes of Internet cruising. Other research has only focused on online sexual behaviours such as cybersex. The present study examines men who find the acts of Internet cruising and emailing to be erotic as self-contained behaviours. We surveyed 499 men who used craigslist.org for sexually-oriented purposes, and ran an ordinary least squares multiple regression model to determine the demographic characteristics of men seeking men who found Internet cruising erotic. Our results showed that younger compared to older men seeking men found the acts erotic. Likewise, men seeking men from mid-sized cities and large cities compared to men from smaller cities found Internet cruising and emailing to be erotic. Most notably, bisexual- and heterosexual-identifying men seeking men compared to gay-identifying men found these acts to be more erotic. Our results suggested that self-contained Internet cruising might provide dual functions. For some men (e.g., heterosexual-identifying men), the behaviour provides a sexual outlet in which fantasy and experimentation may be explored without risking stigmatization. For other men (e.g., those from large cities), the behaviour may be an alternative to offset sexual risk while still being able to 'get off'.

  12. The eroticism of Internet cruising as a self-contained behaviour: a multivariate analysis of men seeking men demographics and getting off online

    Science.gov (United States)

    Robinson, Brandon Andrew; Moskowitz, David A.

    2013-01-01

    Most studies on men seeking men and who use the Internet for sexual purposes have focused on the epidemiological outcomes of Internet cruising. Other research has only focused on online sexual behaviours such as cybersex. The present study examines men who find the acts of Internet cruising and emailing to be erotic as self-contained behaviours. We surveyed 499 men who used craigslist.org for sexually-oriented purposes, and ran an ordinary least squares multiple regression model to determine the demographic characteristics of men seeking men who found Internet cruising erotic. Our results showed that younger compared to older men seeking men found the acts erotic. Likewise, men seeking men from mid-sized cities and large cities compared to men from smaller cities found Internet cruising and emailing to be erotic. Most notably, bisexual- and heterosexual-identifying men seeking men compared to gay-identifying men found these acts to be more erotic. Our results suggested that self-contained Internet cruising might provide dual functions. For some men (e.g., heterosexual-identifying men), the behaviour provides a sexual outlet in which fantasy and experimentation may be explored without risking stigmatization. For other men (e.g., those from large cities), the behaviour may be an alternative to offset sexual risk while still being able to ‘get off’. PMID:23565985

  13. Socio-demographic and health-related factors affecting depression of the Greek population in later life: an analysis using SHARE data.

    Science.gov (United States)

    Verropoulou, Georgia; Tsimbos, Cleon

    2007-09-01

    Depression in later life is one of the most prevalent conditions forecasted to rise to the second most burdensome health condition worldwide by 2020. Using data from the 2004 Study of Health Ageing and Retirement in Europe (SHARE: release 1) on 857 Greek males and 1,032 females aged 50 or higher this study explores, firstly, associations of socio-demographic and health related indicators with depressive symptoms (EURO-D) and, secondly, attempts to identify patterns and structures among them. To achieve the first objective, the 12-item summated EURO-D scale is used in binary form with a cut-off point clinically validated by the EURODEP. Use of logistic regression pinpoints strong associations with gender, years of education, co-morbidity, disability, cognitive function and past depression. Women, less educated persons, those with poor physical health, declining cognitive function and a history of depression are significantly more at risk of scoring higher than three at the EURO-D scale. The role of age is not as clear. To achieve the second objective, multiple correspondence analysis is used in the first instance and factor analysis for binary data subsequently; two components are identified within EURO-D and continuous factor scores are produced. These factors are called "affective suffering" and "motivation". Linear regression models reveal that the first component is responsible for the gender while the second for the age differentials in EURO-D; additionally we find that, apart from physical health indicators which are strongly related to both factors, other associations differ. Further exploration of this differentiation seems of interest, particularly as there is an indication that "motivation" may be an affectively neutral condition.

  14. Using health and demographic surveillance for the early detection of cholera outbreaks: analysis of community- and hospital-based data from Matlab, Bangladesh

    Directory of Open Access Journals (Sweden)

    Dell D. Saulnier

    2016-05-01

    Full Text Available Background: Cholera outbreaks are a continuing problem in Bangladesh, and the timely detection of an outbreak is important for reducing morbidity and mortality. In Matlab, the ongoing Health and Demographic Surveillance System (HDSS data records symptoms of diarrhea in children under the age of 5 years at the community level. Cholera surveillance in Matlab currently uses hospital-based data. Objective: The objective of this study is to determine whether increases in cholera in Matlab can be detected earlier by using HDSS diarrhea symptom data in a syndromic surveillance analysis, when compared to hospital admissions for cholera. Methods: HDSS diarrhea symptom data and hospital admissions for cholera in children under 5 years of age over a 2-year period were analyzed with the syndromic surveillance statistical program EARS (Early Aberration Reporting System. Dates when significant increases in either symptoms or cholera cases occurred were compared to one another. Results: The analysis revealed that there were 43 days over 16 months when the cholera cases or diarrhea symptoms increased significantly. There were 8 months when both data sets detected days with significant increases. In 5 of the 8 months, increases in diarrheal symptoms occurred before increases of cholera cases. The increases in symptoms occurred between 1 and 15 days before the increases in cholera cases. Conclusions: The results suggest that the HDSS survey data may be able to detect an increase in cholera before an increase in hospital admissions is seen. However, there was no direct link between diarrheal symptom increases and cholera cases, and this, as well as other methodological weaknesses, should be taken into consideration.

  15. Using health and demographic surveillance for the early detection of cholera outbreaks: analysis of community- and hospital-based data from Matlab, Bangladesh.

    Science.gov (United States)

    Saulnier, Dell D; Persson, Lars-Åke; Streatfield, Peter Kim; Faruque, A S G; Rahman, Anisur

    2016-01-01

    Cholera outbreaks are a continuing problem in Bangladesh, and the timely detection of an outbreak is important for reducing morbidity and mortality. In Matlab, the ongoing Health and Demographic Surveillance System (HDSS) data records symptoms of diarrhea in children under the age of 5 years at the community level. Cholera surveillance in Matlab currently uses hospital-based data. The objective of this study is to determine whether increases in cholera in Matlab can be detected earlier by using HDSS diarrhea symptom data in a syndromic surveillance analysis, when compared to hospital admissions for cholera. HDSS diarrhea symptom data and hospital admissions for cholera in children under 5 years of age over a 2-year period were analyzed with the syndromic surveillance statistical program EARS (Early Aberration Reporting System). Dates when significant increases in either symptoms or cholera cases occurred were compared to one another. The analysis revealed that there were 43 days over 16 months when the cholera cases or diarrhea symptoms increased significantly. There were 8 months when both data sets detected days with significant increases. In 5 of the 8 months, increases in diarrheal symptoms occurred before increases of cholera cases. The increases in symptoms occurred between 1 and 15 days before the increases in cholera cases. The results suggest that the HDSS survey data may be able to detect an increase in cholera before an increase in hospital admissions is seen. However, there was no direct link between diarrheal symptom increases and cholera cases, and this, as well as other methodological weaknesses, should be taken into consideration.

  16. Material Stock Demographics: Cars in Great Britain.

    Science.gov (United States)

    Cabrera Serrenho, André; Allwood, Julian M

    2016-03-15

    Recent literature on material flow analysis has been focused on quantitative characterization of past material flows. Fewer analyses exist on past and prospective quantification of stocks of materials in-use. Some of these analyses explore the composition of products' stocks, but a focus on the characterization of material stocks and its relation with service delivery is often neglected. We propose the use of the methods of human demography to characterize material stocks, defined herein as stock demographics, exploring the insights that this approach could provide for the sustainable management of materials. We exemplify an application of stock demographics by characterizing the composition and service delivery of iron, steel, and aluminum stocks of cars in Great Britain, 2002-2012. The results show that in this period the stock has become heavier, it is traveling less, and it is idle for more time. The visualization of material stocks' dynamics demonstrates the pace of product replacement as a function of its usefulness and enables the formulation of policy interventions and the exploration of future trends.

  17. Building demographic literacy.

    Science.gov (United States)

    Crews, K

    1993-01-01

    Students should get in the habit of seeking out the most current projections, estimates, or rates available. Since demographic measures change over time, publications based on the UN's world population projections from 1980 or 1990 may need to be supplemented using the UN's most current, 1992, projections. A 1989 Census Bureau report on the African American Population will not contain data from the 1990 Census or the 1992 Current Population Survey, conducted by the Census Bureau. Some groups collect data with advocacy in mind, as shown by the range of estimates of participants at the 1993 National March on Washington for Lesbian, Gay and Bi Equal Rights and Liberation. The organizers estimated that 1 million people participated; the US Park Police estimated 300,000; and the Washington Blade, a gay newspaper, reported 750,000. A seemingly innocuous choice of phrasing can change the meaning of demographic data. One commonly misreported concept is population doubling time which is not a prediction, but rather a concept designed to accent how fast a population is growing at the present time. At current rates, the population of India would double in size in 34 years, but it is more likely that growth rates will begin to slow down somewhat during that time. Older students may be encouraged to examine the assumptions behind population projections. The UN's long-range projection that world population will grow to 10 billion by 2050 is based on certain assumption about fertility and mortality during the period. With regard to the fastest growing US minority, Hispanics added the largest number of people to the US population during the 1980s, but Asians had the largest percent increase. The time to initiate demographic literacy is in the early grades of school.

  18. EJSCREEN Version 1, Demographic Data

    Data.gov (United States)

    U.S. Environmental Protection Agency — This map service displays demographic data used in EJSCREEN. All demographic data were derived from American Community Survey 2006-2010 estimates. EJSCREEN is an...

  19. Analysis of a large dataset of mycorrhiza inoculation field trials on potato shows highly significant increases in yield.

    Science.gov (United States)

    Hijri, Mohamed

    2016-04-01

    An increasing human population requires more food production in nutrient-efficient systems in order to simultaneously meet global food needs while reducing the environmental footprint of agriculture. Arbuscular mycorrhizal fungi (AMF) have the potential to enhance crop yield, but their efficiency has yet to be demonstrated in large-scale crop production systems. This study reports an analysis of a dataset consisting of 231 field trials in which the same AMF inoculant (Rhizophagus irregularis DAOM 197198) was applied to potato over a 4-year period in North America and Europe under authentic field conditions. The inoculation was performed using a liquid suspension of AMF spores that was sprayed onto potato seed pieces, yielding a calculated 71 spores per seed piece. Statistical analysis showed a highly significant increase in marketable potato yield (ANOVA, P < 0.0001) for inoculated fields (42.2 tons/ha) compared with non-inoculated controls (38.3 tons/ha), irrespective of trial year. The average yield increase was 3.9 tons/ha, representing 9.5 % of total crop yield. Inoculation was profitable with a 0.67-tons/ha increase in yield, a threshold reached in almost 79 % of all trials. This finding clearly demonstrates the benefits of mycorrhizal-based inoculation on crop yield, using potato as a case study. Further improvements of these beneficial inoculants will help compensate for crop production deficits, both now and in the future.

  20. Comparative Proteomic Analysis Shows an Elevation of Mdh1 Associated with Hepatotoxicity Induced by Copper Nanoparticle in Rats

    Institute of Scientific and Technical Information of China (English)

    DONG Shu-wei; GAO Zhao-hui; SHEN Xiao-yun; XUE Hui-wen; LI Xia

    2014-01-01

    Copper nanoparticle is a new material widely used in biological medicine, animal husbandry and industrial areas, but its potential toxicity to human health and environment remains unclear. In order to study the hepatotoxic mechanisms of nanoparticles copper, two-dimensional gel electrophoresis (2-DE) and matrix-assisted laser desorption/ionization time of lfight mass spectrometry (MALDI/TOF MS) of proteomics technology were used to isolate and identify the differentially expressed proteins from liver, which associated with hepatotoxicity induced by copper nanoparticle in rats. In this study, we have screened 15 kinds of proteins related with hepatotoxicity, of which spot8212 was identiifed as Malate dehydrogenase (Mdh1). The mRNA expression trend of Mdh1 was consistent with the result of 2-DE by RT-PCR validation. Bioinformatics analysis showed that Mdh1 was stable and no signal peptides, subcellular location was in endoplasmic reticulum;it contained many functional sites such as malate dehydrogenase activity signal sites 155LTRLDHNRAKSQI167; α helixes and random coils were the two main elements. Homologous analysis demonstrated high homologous of Mdh1 in rats with mouse and human, and the phylogenetic tree of Mdh1 was constructed. The result indicated that copper nanoparticle could regulate up the Mdh1 protein expression so as to compensate the energy deifcit. Energy metabolic disturbance may be a pathway for copper nanoparticle particles to exert the hepatotoxic effects in rats.

  1. Subjects with hip osteoarthritis show distinctive patterns of trunk movements during gait-a body-fixed-sensor based analysis

    Directory of Open Access Journals (Sweden)

    Reininga Inge HF

    2012-01-01

    Full Text Available Abstract Background Compensatory trunk movements during gait, such as a Duchenne limp, are observed frequently in subjects with osteoarthritis of the hip, yet angular trunk movements are seldom included in clinical gait assessments. Hence, the objective of this study was to quantify compensatory trunk movements during gait in subjects with hip osteoarthritis, outside a gait laboratory, using a body-fixed-sensor based gait analysis. Frontal plane angular movements of the pelvis and thorax and spatiotemporal parameters of persons who showed a Duchenne limp during gait were compared to healthy subjects and persons without a Duchenne limp. Methods A Body-fixed-sensor based gait analysis approach was used. Two body-fixed sensors were positioned at the dorsal side of the pelvis and on the upper thorax. Peak-to-peak frontal plane range of motion (ROM and spatiotemporal parameters (walking speed, step length and cadence of persons with a Duchenne limp during gait were compared to healthy subjects and persons without a Duchenne limp. Participants were instructed to walk at a self-selected low, preferred and high speed along a hospital corridor. Generalized estimating equations (GEE analyses were used to assess group differences between persons with a Duchenne limp, without a Duchenne limp and healthy subjects. Results Persons with a Duchenne limp showed a significantly larger thoracic ROM during walking compared to healthy subjects and to persons without a Duchenne limp. In both groups of persons with hip osteoarthritis, pelvic ROM was lower than in healthy subjects. This difference however only reached significance in persons without a Duchenne limp. The ratio of thoracic ROM relative to pelvic ROM revealed distinct differences in trunk movement patterns. Persons with hip osteoarthritis walked at a significantly lower speed compared to healthy subjects. No differences in step length and cadence were found between patients and healthy subjects, after

  2. Expression analysis of genes associated with human osteosarcoma tumors shows correlation of RUNX2 overexpression with poor response to chemotherapy

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    Cervigne Nilva K

    2010-05-01

    Full Text Available Abstract Background Human osteosarcoma is the most common pediatric bone tumor. There is limited understanding of the molecular mechanisms underlying osteosarcoma oncogenesis, and a lack of good diagnostic as well as prognostic clinical markers for this disease. Recent discoveries have highlighted a potential role of a number of genes including: RECQL4, DOCK5, SPP1, RUNX2, RB1, CDKN1A, P53, IBSP, LSAMP, MYC, TNFRSF1B, BMP2, HISTH2BE, FOS, CCNB1, and CDC5L. Methods Our objective was to assess relative expression levels of these 16 genes as potential biomarkers of osteosarcoma oncogenesis and chemotherapy response in human tumors. We performed quantitative expression analysis in a panel of 22 human osteosarcoma tumors with differential response to chemotherapy, and 5 normal human osteoblasts. Results RECQL4, SPP1, RUNX2, and IBSP were significantly overexpressed, and DOCK5, CDKN1A, RB1, P53, and LSAMP showed significant loss of expression relative to normal osteoblasts. In addition to being overexpressed in osteosarcoma tumor samples relative to normal osteoblasts, RUNX2 was the only gene of the 16 to show significant overexpression in tumors that had a poor response to chemotherapy relative to good responders. Conclusion These data underscore the loss of tumor suppressive pathways and activation of specific oncogenic mechanisms associated with osteosarcoma oncogenesis, while drawing attention to the role of RUNX2 expression as a potential biomarker of chemotherapy failure in osteosarcoma.

  3. Marmosets, Raree shows and Pulcinelle: an Analysis and Edition of a Hitherto-Unpublished Carnival Play by Antonio de Zamora

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    Fernando Plata

    2013-05-01

    Full Text Available This paper is an analyisis, annotation and edition of the Mojiganga del mundinovo (‘The raree show, a carnival play’ by Antonio de Zamora. The play was performed in 1698 Madrid by the troupe of Carlos Vallejo, along with the sacramental one-act play El templo vivo de Dios (‘The living temple of God’. The hitherto unpublished text is based on the only two extant manuscripts, located in archives in Madrid. Despite the play’s title, my analysis argues that the novelty in this play is not so much the raree show, a contraption popularized four decades earlier in Golden Age theater, as the marmosets. The death of two marmosets and the ensuing desolation of their owner, Ms. Estupenda, both trigger the play and provide it with a plot. The marmosets, too, point to a changing mentality in late 17th-century society, regarding the possession among ladies of marmosets and other monkeys as pets.

  4. Population analysis of the Fusarium graminearum species complex from wheat in China show a shift to more aggressive isolates.

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    Hao Zhang

    Full Text Available A large number of Fusarium isolates was collected from blighted wheat spikes originating from 175 sampling sites, covering 15 provinces in China. Species and trichothecene chemotype determination by multilocus genotyping (MLGT indicated that F. graminearum s. str. with the 15-acetyl deoxynivalenol (15ADON chemotype and F. asiaticum with either the nivalenol (NIV or the 3-acetyl deoxynivalenol (3ADON chemotype were the dominant causal agents. Bayesian model-based clustering with allele data obtained with 12 variable number of tandem repeats (VNTR markers, detected three genetic clusters that also show distinct chemotypes. High levels of population genetic differentiation and low levels of effective number of migrants were observed between these three clusters. Additional genotypic analyses revealed that F. graminearum s. str. and F. asiaticum are sympatric. In addition, composition analysis of these clusters indicated a biased gene flow from 3ADON to NIV producers in F. asiaticum. In phenotypic analyses, F. asiaticum that produce 3ADON revealed significant advantages over F. asiaticum that produce NIV in pathogenicity, growth rate, fecundity, conidial length, trichothecene accumulation and resistance to benzimidazole. These results suggest that natural selection drives the spread of a more vigorous, more toxigenic pathogen population which also shows higher levels of fungicide resistance.

  5. Quantitative fitness analysis shows that NMD proteins and many other protein complexes suppress or enhance distinct telomere cap defects.

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    Stephen Gregory Addinall

    2011-04-01

    Full Text Available To better understand telomere biology in budding yeast, we have performed systematic suppressor/enhancer analyses on yeast strains containing a point mutation in the essential telomere capping gene CDC13 (cdc13-1 or containing a null mutation in the DNA damage response and telomere capping gene YKU70 (yku70Δ. We performed Quantitative Fitness Analysis (QFA on thousands of yeast strains containing mutations affecting telomere-capping proteins in combination with a library of systematic gene deletion mutations. To perform QFA, we typically inoculate 384 separate cultures onto solid agar plates and monitor growth of each culture by photography over time. The data are fitted to a logistic population growth model; and growth parameters, such as maximum growth rate and maximum doubling potential, are deduced. QFA reveals that as many as 5% of systematic gene deletions, affecting numerous functional classes, strongly interact with telomere capping defects. We show that, while Cdc13 and Yku70 perform complementary roles in telomere capping, their genetic interaction profiles differ significantly. At least 19 different classes of functionally or physically related proteins can be identified as interacting with cdc13-1, yku70Δ, or both. Each specific genetic interaction informs the roles of individual gene products in telomere biology. One striking example is with genes of the nonsense-mediated RNA decay (NMD pathway which, when disabled, suppress the conditional cdc13-1 mutation but enhance the null yku70Δ mutation. We show that the suppressing/enhancing role of the NMD pathway at uncapped telomeres is mediated through the levels of Stn1, an essential telomere capping protein, which interacts with Cdc13 and recruitment of telomerase to telomeres. We show that increased Stn1 levels affect growth of cells with telomere capping defects due to cdc13-1 and yku70Δ. QFA is a sensitive, high-throughput method that will also be useful to understand other

  6. The Role of Empowerment in the Association between a Woman's Educational Status and Infant Mortality in Ethiopia: Secondary Analysis of Demographic and Health Surveys.

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    Alemayehu, Yibeltal Kiflie; Theall, Katherine; Lemma, Wuleta; Hajito, Kifle Woldemichael; Tushune, Kora

    2015-10-01

    Socioeconomic status at national, sub-national, household, and individual levels explains a significant portion of variation in infant mortality. Women's education is among the major determinants of infant mortality. The mechanism through which a woman's own educational status, over her husband's as well as household characteristics, influences infant mortality has not been well studied in developing countries. The objective of this study was to explore the role of woman's empowerment and household wealth in the association between a woman's educational status and infant mortality. The association between a woman's educational status and infant death, and the role of woman's empowerment and household wealth in this relationship, were examined among married women in Ethiopia through a secondary, serial cross-sectional analysis utilizing data on birth history of married women from three rounds of the Ethiopian Demographic and Health Survey. Univariate, bivariate, and multivariate analyses were conducted to examine the association between woman's education and infant death, and the possible mediation or moderation roles of woman empowerment and household wealth. Female education and empowerment were inversely associated with infant death. The results indicated mediation by empowerment in the education-infant death association, and effect modification by household wealth. Both empowerment and education had strongest inverse association with infant death among women from the richest households. The findings suggest an important role of female empowerment in the education-infant death relation, and the complexity of these factors according to household wealth. Woman empowerment programs may prove effective as a shorter term intervention in reducing infant mortality.

  7. Clinicopathological and demographical characteristics of non-small cell lung cancer patients with ALK rearrangements: a systematic review and meta-analysis.

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    Liang Fan

    Full Text Available This meta-analysis aimed to comprehensively examine the relationship between the clinicopathological and demographical characteristics and ALK rearrangements in patients with non-small cell lung cancer (NSCLC.In total, 62 qualified articles including 1178 ALK rearranged cases from 20541 NSCLC patients were analyzed, and the data were extracted independently by two investigators. NSCLC patients with ALK rearrangements tended to be younger than those without (mean difference: -7.16 years; 95% confidence interval (95% CI: -9.35 to -4.96; P<0.00001, even across subgroups by race. Compared with female NSCLC patients, the odds ratio (OR of carrying ALK rearrangements was reduced by 28% (95% CI: 0.58-0.90; P = 0.004 in males, and this reduction was potentiated in Asians, yet in opposite direction in Caucasians. Likewise, smokers were less likely to have ALK rearrangements than never-smokers (OR = 0.33; 95% CI: 0.25-0.44; P<0.00001, even in race-stratified subgroups. Moreover, compared with NSCLC patients with tumor stage IV, ALK rearrangements were underrepresented in those with tumor stage I-III (OR = 0.58; 95% CI: 0.44-0.78; P = 0.0002. Patients with lung adenocarcinomas had a significantly higher rate of ALK rearrangements (7.2% than patients with non-adenocarcinoma (2.0% (OR = 2.25; 95% CI: 1.54-3.27; P<0.0001.Our findings demonstrate that ALK rearrangements tended to be present in NSCLC patients with no smoking habit, younger age and tumor stage IV. Moreover, race, age, gender, smoking status, tumor stage and histology might be potential sources of heterogeneity.

  8. Socio-demographic and clinical differences in subjects with tuberculosis with and without diabetes mellitus in Brazil--a multivariate analysis.

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    Barbara Reis-Santos

    Full Text Available BACKGROUND: Several studies have evaluated the relationship between diabetes mellitus (DM and tuberculosis (TB, but the nature of this relationship is not fully understood. TB incidence may be influenced by immunosuppression from DM, but this association may be confounded by other clinical and socioeconomic factors. We aimed to assess socio-demographic and clinical differences in TB patients with and without DM. METHODS: Using the Brazilian national surveillance system (SINAN, we compared 1,797 subjects with TB and DM with 29,275 subjects diagnosed with TB only in 2009. We performed multivariate analysis to identify factors associated with the presence of DM among TB patients. RESULTS: Subjects with TB - DM were older; have initial positive sputum smear test (OR = 1.42, 95% CI 1.26-1.60, and were more likely to die from TB (OR = 1.44, 95% CI 1.03-2.01. They were less likely to have been institutionalized [in prison, shelter, orphanage, psychiatric hospital (OR = 0.74, 95% CI 0.60-0.93]; developed extra pulmonary TB (OR = 0.62, 95% CI 0.51-0.75 and to return to TB treatment after abandonment (OR = 0.66, 95% CI 0.51-0.86. CONCLUSIONS: Prevalence of NCD continues to rise in developing countries, especially with the rise of elderly population, the prevention and treatment of infectious diseases will be urgent. DM and TB represent a critical intersection between communicable and non-communicable diseases in these countries and the effect of DM on TB incidence and outcomes provide numerous opportunities for collaboration and management of these complex diseases in the national public health programs.

  9. Socio-Demographic and Clinical Differences in Subjects with Tuberculosis with and without Diabetes Mellitus in Brazil – A Multivariate Analysis

    Science.gov (United States)

    Reis-Santos, Barbara; Locatelli, Rodrigo; Horta, Bernardo L.; Faerstein, Eduardo; Sanchez, Mauro N.; Riley, Lee W.; Maciel, Ethel Leonor

    2013-01-01

    Background Several studies have evaluated the relationship between diabetes mellitus (DM) and tuberculosis (TB), but the nature of this relationship is not fully understood. TB incidence may be influenced by immunosuppression from DM, but this association may be confounded by other clinical and socioeconomic factors. We aimed to assess socio-demographic and clinical differences in TB patients with and without DM. Methods Using the Brazilian national surveillance system (SINAN), we compared 1,797 subjects with TB and DM with 29,275 subjects diagnosed with TB only in 2009. We performed multivariate analysis to identify factors associated with the presence of DM among TB patients. Results Subjects with TB – DM were older; have initial positive sputum smear test (OR = 1.42, 95% CI 1.26–1.60), and were more likely to die from TB (OR = 1.44, 95% CI 1.03–2.01). They were less likely to have been institutionalized [in prison, shelter, orphanage, psychiatric hospital (OR = 0.74, 95% CI 0.60–0.93)]; developed extra pulmonary TB (OR = 0.62, 95% CI 0.51–0.75) and to return to TB treatment after abandonment (OR = 0.66, 95% CI 0.51–0.86). Conclusions Prevalence of NCD continues to rise in developing countries, especially with the rise of elderly population, the prevention and treatment of infectious diseases will be urgent. DM and TB represent a critical intersection between communicable and non-communicable diseases in these countries and the effect of DM on TB incidence and outcomes provide numerous opportunities for collaboration and management of these complex diseases in the national public health programs. PMID:23638123

  10. Analysis of Perceptions of Customers of Cellular Phone Users in India: Study with Prepaid Service Customers and Post Paid Customers Demographic Factors

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    S. Muthumani

    2014-10-01

    Full Text Available The primary objective of the study is to find out and analyze the customer perceptions on cellular phone services in India. Cellular phones are become the part of the life and the various barriers in the obtaining and usage of cellular services are lack of awareness, cost factor, perceptions of the customers on cellular phones etc. In addition the service quality, customer care, market competition brings lot of instability and reliability of the services. In turn it makes further confusion among the users. It paves an opportunity of providing limited services in the selective areas. It leads to a wide gap in the service quality and reliability between the urban and semi urban areas. It gives an opportunity to the researcher to survey on the facts and perceptions of the cellular phone users to find out the real situation and to suggest appropriate suggestions to overcome the issues in the market expansion and to improve the service quality of the cellular phone services in the sample area. To do this, the researcher selects a comparative approach. The data is collected by preparing a structured questionnaire and collected from the cellular phone users in the sample area. The study centered, in comparing the customers perceptions towards cellular phone services provided by the different operators in the states of India. The customers are from both urban and semi-urban places of India. In addition, customers were also classified on the basis of the type of services usage (i.e., post paid or pre paid. The basic parameters used for the purpose of comparing their perceptions are purpose of usage. The study has taken the demographic factors of respondents for analysis.

  11. Composite likelihood estimation of demographic parameters

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    Garrigan Daniel

    2009-11-01

    accuracy, demographic parameters from three simulated data sets that vary in the magnitude of a founder event and a skew in the effective population size of the X chromosome relative to the autosomes. The behavior of the Markov chain is also examined and shown to convergence to its stationary distribution, while also showing high levels of parameter mixing. The analysis of three pairwise comparisons of sub-Saharan African human populations with non-African human populations do not provide unequivocal support for a strong non-African founder event from these nuclear data. The estimates do however suggest a skew in the ratio of X chromosome to autosome effective population size that is greater than one. However in all three cases, the 95% highest posterior density interval for this ratio does include three-fourths, the value expected under an equal breeding sex ratio. Conclusion The implementation of composite and approximate likelihood methods in a framework that includes MCMCMC demographic parameter estimation shows great promise for being flexible and computationally efficient enough to scale up to the level of whole-genome polymorphism and divergence analysis. Further work must be done to characterize the effects of the assumption of linkage equilibrium among genomic regions that is crucial to the validity of applying the composite likelihood method.

  12. Demographic Analysis of Sex Ratio on Population Growth of Bactrocera dorsalis (Diptera: Tephritidae) With Discussion of Control Efficacy Using Male Annihilation.

    Science.gov (United States)

    Yu-Bing Huang, Kevin; Atlihan, Remzi; Gökçe, Ayhan; Yu-Bing Huang, Joyce; Chi, Hsin

    2016-09-30

    The life table data for the oriental fruit fly, Bactrocera dorsalis (Hendel), at different adult sex ratios (1♀: 1♂, 1♀: 50♂, 50♀: 1♂ free-choice mating, and 50♀: 1♂ no-choice mating) were collected to determine the effects of sex-ratio manipulation on current pest control procedures. At 1♀: 1♂, females mated, on average, 2.3 times during their lifetime with a mean fecundity (F) of 1,122 eggs. The net reproductive rate (R0), intrinsic rate of increase (r), finite rate (λ), and mean generation time (T) were 561.0 offspring, 0.1693 d(-)  (1), 1.1844 d(-)  (1), and 37.4 d, respectively. At 50♀: 1♂ free-choice mating, males mated 46.7 times during their lifetime, while at 50♀: 1♂ no-choice mating, males mated on average 50 times during their lifetime, and all females mating only once in both treatments. The values for F, r, and λ were significantly lower for both 50♀: 1♂ treatments than those in the 1♀: 1♂ group; the R0 values, however, were either equal to or even higher than those in the 1♀: 1♂ treatment. In the male-biased sex ratio (1♀: 50♂), fecundity was the highest (1,610 eggs) and female average life span the longest (166 d), while the R0 was the lowest (31.6 offspring) among all treatments. Population projections showed that even at a sex ratio of 50♀: 1♂, B. dorsalis could still produce a large number of offspring. These findings demonstrate that management strategies for controlling B. dorsalis could be properly evaluated by using demographic methods. Because female annihilation appears to be a more effective control strategy, it should be considered as a viable alternative.

  13. Gender inequalities from the demographic perspective

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    Devedžić Mirjana

    2006-01-01

    Full Text Available The paper analyzes the meaning of the phrase "the woman’s status in the society" that is recognized in demography as an important cultural factor of demographic development and transitional changes. The analysis indicates qualitative shifts in the woman’s status and simultaneously reveals its importance at present, not only in traditional, but also in modern and developed societies. On the other hand, it explains the importance of sex as a biodemographic determinant, and introduces the concept of gender that sheds another light on the concepts of sex and woman’s status in the society and integrates them. Gender regimes that subsume the inferiority of women in public and private social structures are examined from demographic perspective, albeit only in those phenomenological aspects that can be supported by demographic research, theories, and analyses. To this end, the paper analyzes the effects of strengthening gender equalities on the fertility and mortality transitions, the gender’s impact on the population distribution by sex in South Asian countries, and highlights the key role of gender in interpreting certain social and economic structures. It also stresses the establishing of gender equality as an important element of population policies. The global dimension of the patriarchal society is illustrated through a series of examples of demographic phenomena from various societies. Gender regimes underlie all of these phenomena. The paper puts foreword certain theoretical hypotheses about gender inequalities, and finds their connections with demographic behaviors and demographic indicators. Finally, it summarizes the role of demography in gender (inequality research and the demographic perspective of the way and the speed the demographic equality is being established. Demography is seen as an irreplaceable discipline in examining gender inequalities, especially at the global level. With the advance of qualitative methods in demography

  14. Significance of Demographic Variables for Targeting of Internet Advertisements

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    Václav Stříteský

    2016-06-01

    Full Text Available Broad ad targeting options belong among the major advantages of internet advertising. Demographic targeting has become a standard option in most of on-line advertising systems. There are more ways how to target on-line advertisements by using demographic variables. In some cases, e.g., social media, we can use data from user registrations. Modern technologies enable to estimate the demographic profile of internet users using on behavioural data. The traditional approach to the demographic targeting of advertisements based on affinity targeting assumes the existence of internet servers with sufficient homogeneity of visits. The aim of this article is to identify the differences in the internet content consumption habits of Czech internet users based on gender and age. The analysis is based on the data from the extensive research which was carried out by the Netmonitor project, and which was provided for the purposes of this study by the Association for Internet Development (SPIR. The research results show that the traditional affinity-based method of targeting according to gender and age is still suitable on the Czech internet. On the other hand, in some cases, the traditional approach of ad targeting based on affinity leads to wasted ad impressions that miss defined target group.

  15. The impact of demographic change on intergenerational transfers via bequests

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    Emilio Zagheni

    2015-09-01

    Full Text Available Background: Transfers in the form of bequests have important implications for the intergenerational transmission of inequality. Demographic change has relevant consequences for the timing and size of bequests. For example, longer life implies that people receive bequests when they are older. Conversely, increasing generational length reduces the average age at which people are given bequests. Objective: We analyze the consequences of demographic change in the United States on timing over the life course when individuals receive an inheritance and on the size of bequests. Methods: We evaluate trends in life expectancy at the mean age at childbearing as a proxy for timing at receipt of bequests. We complement formal demographic analysis with empirical estimates from the Panel Study of Income Dynamics (PSID inheritance data for 1987-2010. Results: We find that the long-term trend of increasing age at receipt of bequests might have stalled, mainly because of changes in the timing of fertility. In the long term the upward trend in age at which people receive bequests may resume, as the expected linear gains in life expectancy will more than counteract recent increases in the mean age at childbearing. Conclusions: We showed that demographic change affects the size of bequests and the timing over the life course when people receive them. As the need for economic resources varies over the life cycle, changes in the timing at receipt of bequests may have a differential impact on wealth inequality and affect patterns of multigenerational transfers of resources.

  16. The neolithic demographic transition in Europe: correlation with juvenility index supports interpretation of the summed calibrated radiocarbon date probability distribution (SCDPD as a valid demographic proxy.

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    Sean S Downey

    Full Text Available Analysis of the proportion of immature skeletons recovered from European prehistoric cemeteries has shown that the transition to agriculture after 9000 BP triggered a long-term increase in human fertility. Here we compare the largest analysis of European cemeteries to date with an independent line of evidence, the summed calibrated date probability distribution of radiocarbon dates (SCDPD from archaeological sites. Our cemetery reanalysis confirms increased growth rates after the introduction of agriculture; the radiocarbon analysis also shows this pattern, and a significant correlation between both lines of evidence confirms the demographic validity of SCDPDs. We analyze the areal extent of Neolithic enclosures and demographic data from ethnographically known farming and foraging societies and we estimate differences in population levels at individual sites. We find little effect on the overall shape and precision of the SCDPD and we observe a small increase in the correlation with the cemetery trends. The SCDPD analysis supports the hypothesis that the transition to agriculture dramatically increased demographic growth, but it was followed within centuries by a general pattern of collapse even after accounting for higher settlement densities during the Neolithic. The study supports the unique contribution of SCDPDs as a valid demographic proxy for the demographic patterns associated with early agriculture.

  17. Prognostic impact of demographic factors and clinical features on the mode of death in high-risk patients after myocardial infarction--a combined analysis from multicenter trials

    DEFF Research Database (Denmark)

    Yap, Yee Guan; Duong, Trinh; Bland, J Martin

    2005-01-01

    BACKGROUND: Contemporary information is lacking on the effect of demographic features and clinical features on the specific mode of mortality after myocardial infarction (MI) in the thrombolytic era. HYPOTHESIS: The aims of this study were (1) to examine the risk and trend of a different mode of ...

  18. A Comparative Analysis of Demographic and Academic Characteristics and NCLEX-RN Passing among Urban and Rural Campus Students in a Midwest Associate Degree Nursing Program

    Science.gov (United States)

    Nacos-Burds, Kathleen J.

    2010-01-01

    A retrospective study was initiated to determine: (1) the predictive relationship between demographic and academic variables and NCLEX-RN success; and (2) if there were significant differences between urban and rural nursing students that could account for an increased percentage of rural NCLEX-RN failures. A convenience sample was comprised of…

  19. Demographic characteristics, social competence, and behavior problems in children with gender identity disorder : A cross-national, cross-clinic comparative analysis

    NARCIS (Netherlands)

    Cohen-Kettenis, PT; Owen, A; Kaijser, VG; Bradley, SJ; Zucker, KJ

    2003-01-01

    This study examined demographic characteristics, social competence, and behavior problems in clinic-referred children with gender identity problems in Toronto, Canada (N = 358), and Utrecht, The Netherlands (N = 130). The Toronto sample was, on average, about a year younger than the Utrecht sample a

  20. Institutional delivery in public and private sectors in South Asia: A comparative analysis of prospective data from four demographic surveillance sites

    NARCIS (Netherlands)

    S. Das (Sushmita); G. Alcock (Glyn); K. Azad (Kishwar); A. Kuddus (Abdul); A. Manandhar; B. Shrestha (Bhim); N. Nair (Nirmala); S. Rath (Santosh); N.S. More (Neena Shah); N. Saville (Naomi); A.J. Houweling (Tanja); D. Osrin (David)

    2016-01-01

    markdownabstract__Background:__ Maternity care in South Asia is available in both public and private sectors. Using data from demographic surveillance sites in Bangladesh, Nepal and rural and urban India, we aimed to compare institutional delivery rates and public-private share. __Methods:__ We us

  1. Demographic patterns and trends in Central Ghana: baseline indicators from the Kintampo Health and Demographic Surveillance System

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    Seth Owusu-Agyei

    2012-12-01

    Full Text Available Background: The dearth of health and demographic data in sub-Saharan Africa from vital registration systems and its impact on effective planning for health and socio-economic development is widely documented. Health and Demographic Surveillance Systems have the capacity to address the dearth of quality data for policy making in resource-poor settings. Objective: This article demonstrates the utility of the Kintampo Health and Demographic Surveillance System (KHDSS by showing the patterns and trends of population change from 2005 to 2009 in the Kintampo North Municipality and Kintampo South districts of Ghana through data obtained from the KHDSS biannual update rounds. Design: Basic demographic rates for fertility, mortality, and migration were computed by year. School enrolment was computed as a percentage in school by age and sex for 6–18 year-olds. Socio-economic status was derived by use of Principal Components Analysis on household assets. Results: Over the period, an earlier fertility decline was reversed in 2009; mortality declined slightly for all age-groups, and a significant share of working-age population was lost through out-migration. Large minorities of children of school-going age are not in school. Socio-economic factors are shown to be important determinants of fertility and mortality. Conclusion : Strengthening the capacity of HDSSs could offer added value to evidence-driven policymaking at local level.

  2. Demographic aspects of social security in region

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    Alla Gennad'evna Leont'eva

    2012-06-01

    Full Text Available This paper presents a situational analysis of the level of life safety in the field of demographic regions of the Ural Federal District. The analysis is based on data from the Federal Statistics and covers the period 2000-2010. We have developed a system of indicators for evaluating safety in the demographic sphere. We set the main threats to the social and economic stability in the regions. The system of thresholds includes three blocks: the reproduction of the population, marriage and family relationships and health. We have presented a quantitative description of the main threats. Identified priority areas of social protection, providing increased stability of the regional socio-economic development, reducing the likelihood of social conflicts and improve the demographic situation.

  3. Evolution Analysis of the Aux/IAA Gene Family in Plants Shows Dual Origins and Variable Nuclear Localization Signals

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    Wentao Wu

    2017-10-01

    Full Text Available The plant hormone auxin plays pivotal roles in many aspects of plant growth and development. The auxin/indole-3-acetic acid (Aux/IAA gene family encodes short-lived nuclear proteins acting on auxin perception and signaling, but the evolutionary history of this gene family remains to be elucidated. In this study, the Aux/IAA gene family in 17 plant species covering all major lineages of plants is identified and analyzed by using multiple bioinformatics methods. A total of 434 Aux/IAA genes was found among these plant species, and the gene copy number ranges from three (Physcomitrella patens to 63 (Glycine max. The phylogenetic analysis shows that the canonical Aux/IAA proteins can be generally divided into five major clades, and the origin of Aux/IAA proteins could be traced back to the common ancestor of land plants and green algae. Many truncated Aux/IAA proteins were found, and some of these truncated Aux/IAA proteins may be generated from the C-terminal truncation of auxin response factor (ARF proteins. Our results indicate that tandem and segmental duplications play dominant roles for the expansion of the Aux/IAA gene family mainly under purifying selection. The putative nuclear localization signals (NLSs in Aux/IAA proteins are conservative, and two kinds of new primordial bipartite NLSs in P. patens and Selaginella moellendorffii were discovered. Our findings not only give insights into the origin and expansion of the Aux/IAA gene family, but also provide a basis for understanding their functions during the course of evolution.

  4. Factors influencing place of delivery for women in Kenya: an analysis of the Kenya demographic and health survey, 2008/2009

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    Kitui John

    2013-02-01

    Full Text Available Abstract Background Maternal mortality in Kenya increased from 380/100000 live births to 530/100000 live births between 1990 and 2008. Skilled assistance during childbirth is central to reducing maternal mortality yet the proportion of deliveries taking place in health facilities where such assistance can reliably be provided has remained below 50% since the early 1990s. We use the 2008/2009 Kenya Demographic and Health Survey data to describe the factors that determine where women deliver in Kenya and to explore reasons given for home delivery. Methods Data on place of delivery, reasons for home delivery, and a range of potential explanatory factors were collected by interviewer-led questionnaire on 3977 women and augmented with distance from the nearest health facility estimated using health facility Global Positioning System (GPS co-ordinates. Predictors of whether the woman’s most recent delivery was in a health facility were explored in an exploratory risk factor analysis using multiple logistic regression. The main reasons given by the woman for home delivery were also examined. Results Living in urban areas, being wealthy, more educated, using antenatal care services optimally and lower parity strongly predicted where women delivered, and so did region, ethnicity, and type of facilities used. Wealth and rural/urban residence were independently related. The effect of distance from a health facility was not significant after controlling for other variables. Women most commonly cited distance and/or lack of transport as reasons for not delivering in a health facility but over 60% gave other reasons including 20.5% who considered health facility delivery unnecessary, 18% who cited abrupt delivery as the main reason and 11% who cited high cost. Conclusion Physical access to health facilities through distance and/or lack of transport, and economic considerations are important barriers for women to delivering in a health facility in Kenya

  5. Patient use of email for health care communication purposes across 14 European countries: an analysis of users according to demographic and health-related factors.

    Science.gov (United States)

    Newhouse, Nikki; Lupiáñez-Villanueva, Francisco; Codagnone, Cristiano; Atherton, Helen

    2015-03-06

    The use of the Internet for health purposes is growing steadily, yet the use of asynchronous communication tools for health care purposes remains undeveloped. The introduction of email as a method of communication in health care has the potential to impact on both patients and health care professionals. This study aims to describe the characteristics of people who have sent or received an email to or from their doctor, nurse, or health care organization, by country and in relation to demographics, health care resource use, and health status factors. We conducted a secondary analysis of data (N=14,000) collected from the online Citizens and Information Communication Technology for Health survey, a project undertaken in 2011 by the Institute for Prospective Technology Studies of the European Commission's Joint Research Centre. The survey was developed to understand and characterize European citizens' use of information communication technologies for health. Descriptive and statistical analyses of association were used to interpret the data. Denmark reported the highest level of emails sent/received (507/1000, 50.70%). The lowest level reported was by participants in France (187/1000, 18.70%). Men used email communication for health care more than women, as did respondents in the 16-24 age group and those educated to tertiary level or still within the education system. As self-reported health state worsens, the proportion of people reporting having sent or received an email within the context of health care increases. Email use, poor health, multimorbidity, and number of visits to a physician are positively correlated. The use of email communication within the context of European health care is extremely varied. The relationship between high email use, poor health, doctor visits, and multimorbidity is especially pertinent: provision of asynchronous communication for such groups is favored by policymakers. Low reported email use by country may not necessarily reflect

  6. Factors Associated with Ever Being HIV-Tested in Zimbabwe: An Extended Analysis of the Zimbabwe Demographic and Health Survey (2010-2011.

    Directory of Open Access Journals (Sweden)

    Kudakwashe Collin Takarinda

    Full Text Available Zimbabwe has a high human immunodeficiency virus (HIV burden. It is therefore important to scale up HIV-testing and counseling (HTC as a gateway to HIV prevention, treatment and care.To determine factors associated with being HIV-tested among adult men and women in Zimbabwe.Secondary analysis was done using data from 7,313 women and 6,584 men who completed interviewer-administered questionnaires and provided blood specimens for HIV testing during the Zimbabwe Demographic and Health Survey (ZDHS 2010-11. Factors associated with ever being HIV-tested were determined using multivariate logistic regression.HIV-testing was higher among women compared to men (61% versus 39%. HIV-infected respondents were more likely to be tested compared to those who were HIV-negative for both men [adjusted odds ratio (AOR = 1.53; 95% confidence interval (CI (1.27-1.84] and women [AOR = 1.42; 95% CI (1.20-1.69]. However, only 55% and 74% of these HIV-infected men and women respectively had ever been tested. Among women, visiting antenatal care (ANC [AOR = 5.48, 95% CI (4.08-7.36] was the most significant predictor of being tested whilst a novel finding for men was higher odds of testing among those reporting a sexually transmitted infection (STI in the past 12 months [AOR = 1.86, 95%CI (1.26-2.74]. Among men, the odds of ever being tested increased with age ≥ 20 years, particularly those 45-49 years [AOR = 4.21; 95% CI (2.74-6.48] whilst for women testing was highest among those aged 25-29 years [AOR = 2.01; 95% CI (1.63-2.48]. Other significant factors for both sexes were increasing education level, higher wealth status and currently/formerly being in union.There remains a high proportion of undiagnosed HIV-infected persons and hence there is a need for innovative strategies aimed at increasing HIV-testing, particularly for men and in lower-income and lower-educated populations. Promotion of STI services can be an important gateway for testing more men whilst ANC

  7. Does Financial Literacy Moderate the Relationship among Demographic Characteristics and Financial Risk Tolerance? Evidence from Egypt

    Directory of Open Access Journals (Sweden)

    Amir Ali Shusha

    2017-09-01

    Full Text Available Financial risk tolerance is certainly an important topic for researchers, investors and personal financial planners or consultants. This study purposed to investigate the effect of demographic characteristics on financial risk tolerance among Egyptians. A literature review of demographic determinants of financial risk tolerance showed dialectical results. Therefore, this study attempts to clarify the debatable issues in these results by studying the moderating role of financial literacy in relationships among demographic characteristics and financial risk tolerance. The study sample included 386 respondents representing different segments of Egyptian people. Using the hierarchical regression analysis, the results demonstrated that there were significant effects of gender, age, educational level and annual income on financial risk tolerance. Moreover, the financial literacy moderates the relationships among demographic characteristics of individuals and their tendency to take a risk.

  8. The demographic picture of Belgrade at the beginning of the 21st century

    Directory of Open Access Journals (Sweden)

    Rašević Mirjana

    2006-01-01

    Full Text Available The central part of this paper is devoted to establishing the demographic picture of the City of Belgrade at the beginning of the 21st century. The authors discuss the number of inhabitants and the components of demographic growth through natural increase (fertility and mortality on the one hand and net migration on the other. Special attention was paid to the problem of refugees (the number and special distribution of refugees. Age and sex structure, the structure by marital status, as well as educational, and economic structures were analyzed. Current ethnic structure, as well as the changes in this structure since the early 1990s, were also presented. The analysis of the demographic picture has made it possible, first of all, to show the implications for the future of the established population trends, and second of all, to single out the basic demographic problems that need to be addressed strategically by the City of Belgrade and by the State.

  9. Low Contraceptive Use among Young Females in Uganda: Does Birth History and Age at Birth have an Influence? Analysis of 2011 Demographic and Health Survey

    Science.gov (United States)

    Kabagenyi, Allen; Habaasa, Gilbert; Rutaremwa, Gideon

    2017-01-01

    Background Globally adolescent fertility has been associated with increased risk to maternal and child health morbidity and mortality. The low use of contraception has been associated with high fertility levels, which is remains a public health concern that efforts have been raised to avert this. We examine the influence history of a previous birth and age at first birth would have on young women’s use of contraception. Methods Using the 2011 Uganda Demographic and Health Survey data, we examine the predictors of contraceptive use on a sample of 3692 young females in Uganda. While controlling for education and age of respondents, logistic regression analyses were run to provide the net effect of the examined predictors on contraceptive use. The study variables included age of respondents, marital status, age at first birth, births in past five years, socioeconomic status, residence, region, education level, religion, occupation and whether the last child was wanted. Results The findings show that only 12% of the adolescents were using contraception at the time of the survey. The key predictors of contraceptive use among young women in Uganda were age at first birth, history of previous birth, current age, and place of residence, education and socioeconomic status. Respondents who had a birth in the 5 years prior to the survey had five times (OR = 5.0, 95% CI = 3.7-6.5) the odds of contraceptive use compared to those who had never had a birth. Further, adolescent females with at least a secondary education were more likely to use contraceptives (OR = 1.55, 95% CI = 1.2-2.0) than those with primary education. The odds of contraceptive use were least among adolescents from Northern region (OR = 0.39, 95% CI = 0.2-0.6) compared to those from central region of Uganda. Muslim adolescent females were more likely to use contraceptives compared to Catholics (OR = 1.59, 95% CI = 1.1-2.3). Conclusion There is great need to address issues that hinder young people from using

  10. SELECTED DETERMINANTS OF DEMOGRAPHIC SAFETY

    Directory of Open Access Journals (Sweden)

    Stanisława Ostasiewicz

    2016-09-01

    Full Text Available The article presents, in a simplifi ed manner, selected theories of population to explain the current trends of population development in Poland and throughout the world. The aim of the article is to present the demographic threats that have emerged in the last eighty years. Prognosticated age structures have also been predicted. Signifi cant diff erences between the structure of the population now and the future have been indicated, particularly regarding the ageing of the population. Against the background of global transformations analyzes of changes in Poland have been conducted. The comparison shows that changes in Poland are highly analogous to transformations around the world, such as declining birth rates and increasing life expectancy. These changes cause ageing of the population, which could result in the collapse of the functioning of the labor market and the pension system as it currently exists.

  11. Economic and Demographic Predictors of Inclusive Education

    Science.gov (United States)

    Cosier, Meghan E.; Causton-Theoharis, Julie

    2011-01-01

    This study investigated economic and demographic predictors of levels of inclusion of students with disabilities in 129 school districts. Multiple regression analysis was utilized to address the following research questions: (a) Is there a relationship between economic factors and percentage of highly included students with disabilities in general…

  12. [Demographic profile of Venezuela].

    Science.gov (United States)

    Quintero, I

    1984-04-01

    Sources of demographic data for Venezuela include 11 population censuses conducted between 1873-1981, birth and death registration statistics, and the household sample survey. The average annual rate of population growth increase from 2.8% between 1920-40 to 3-4% thereafter. The population at the 1961 census was 7.52 million. According to preliminary data from the 1981 census, the population of 14.57 million is growing at an annual rate of 2.8%. 41.2% of the population is under 15 years old, implying a huge demand for educational and health services, housing and employment. The dependency rate in 1980 was 81.3% for the country as a whole, 100.4% in rural areas, and 76.0% in urban areas. The young age structure means that the population will continue to grow even if natality rates decline. The crude natality rate was estimated at 47.3/1000 for 1950-55, 36.0 for 1970-75, and 32.9 for 1980-85. Some rural areas still have natality rates of over 47/1000. The total fertility rate declined from 6.5 in 1950-55 to 4.1 in 1980-85. The decline in the natality rate reflects improving quality of life, availability of family planning services, urbanization, and access of women to productive activities and educational centers. The mortality rate was 12.3/1000 in 1950-55, 9.1 in 1960-65, in 1970-75, and has been estimated at 5.5 for 1980-85. Some rural areas have mortality rates of 8.1. The infant mortality rate was 50.2/1000 in 1971 and 34.3 in 1980. Life expectancy at birth is about 69 years. During the 1920s, Venezuela unerwent expansion in infrastructure and technological utilization, generating rapid urbanization. 39.2% of the population was urban in 1941, compared to 78.8% in 1980. The significance of urbanization in Venezuela is due to the rapidity as well as the diffusion of the process. The household sample survey for the 2nd half of 1980 indicated a total of 8.16 million employed and an activity rate of 32.1% overall, 46.4% for males and 17.7% for females. The

  13. Demographic and affective covariates of pain.

    Science.gov (United States)

    Garron, D C; Leavitt, F

    1979-11-01

    Relationships of four demographic variables and five affective variables to eight attributes of low back pain were investigated in 251 patients by stepwise, multivariate analysis. The demographic variables are age, sex, race, and education. The affective variables are state anxiety, trait anxiety anxiety, hostility, and depression. Seven of the pain variables are from the factorially derived Low Back Pain Questionnaire. The eighth pain variable is a self-estimate of intensity. Relationships among demographic and pain variables are small and unsystematic. Hostility has a small, systematically inverse relation to pain variables, supporting theories relating low back pain to inhibition of anger. Anxiety has a small positive relationship, and depression has no relationship to pain variables. In general, the small relationships indicate that the Low Back Pain Questionnaire provides descriptions of pain that are not confounded by social characteristics or current emotional states of patients.

  14. Trust and its Relationship to Demographic Factors

    Directory of Open Access Journals (Sweden)

    Asghar Mirfardi

    2011-01-01

    Full Text Available Problem statement: Social trust is the main theme in the social life. Trust is “the expectation that arises within a community of regular, honest and cooperative behavior, based on commonly shared norms”. Development, social trust and security are intertwined categories and have interaction to each other. Social trust, as a main factor in social capital, provide social context for developmental programs. This study, examine the affect of Demographic factors on the social trust to others. As social trust is a key factor in social relationship, this study is needed to evaluate such factor according to demographic factors. Approach: This study has been done on existing data about Iranian values and attitudes. Some factors such as gender, age, education level, job situation, marital situation have been studied in this study. Some of these variables such as education, correspondence to development level, especially in social development. This study is done via documental method (archive and Documental data about mentioned themes and second analysis of The Iranian National Values and attitudes Survey (2000. Results: Findings of this study indicated that there is significant relationship between all of independent variables (Gender, age, education level, job situation, marital situation and social trust to families and relatives, there is significant relationship between variables such as gender, education level, job situation, marital situation (independent variables and social trust to friends. Analyzing the data showed that, the residents of less and more developed cities have different situation in trust. Conclusion/Recommendations: This study introduces three types of trust upon the development level of societies. Trust in Iran is an example of trust structure in developing societies.

  15. Prevalence and socio-demographic correlates of cooking skills in UK adults: cross-sectional analysis of data from the UK National Diet and Nutrition Survey.

    Science.gov (United States)

    Adams, Jean; Goffe, Louis; Adamson, Ashley J; Halligan, Joel; O'Brien, Nicola; Purves, Richard; Stead, Martine; Stocken, Deborah; White, Martin

    2015-08-05

    Poor cooking skills may be a barrier to healthy eating and a contributor to overweight and obesity. Little population-representative data on adult cooking skills has been published. We explored prevalence and socio-demographic correlates of cooking skills among adult respondents to wave 1 of the UK National Diet and Nutrition Survey (2008-9). Socio-demographic variables of interest were sex, age group, occupational socio-economic group and whether or not respondents had the main responsibility for food in their households. Cooking skills were assessed as self-reported confidence in using eight cooking techniques, confidence in cooking ten foods, and ability to prepare four types of dish (convenience foods, a complete meal from ready-made ingredients, a main meal from basic ingredients, and cake or biscuits from basic ingredients). Frequency of preparation of main meals was also reported. Of 509 respondents, almost two-thirds reported cooking a main meal at least five times per week. Around 90 % reported being able to cook convenience foods, a complete meal from ready-made ingredient, and a main dish from basic ingredients without help. Socio-demographic differences in all markers of cooking skills were scattered and inconsistent. Where these were found, women and main food providers were most likely to report confidence with foods, techniques or dishes, and respondents in the youngest age (19-34 years) and lowest socio-economic group least likely. This is the only exploration of the prevalence and socio-demographic correlates of adult cooking skills using recent and population-representative UK data and adds to the international literature on cooking skills in developed countries. Reported confidence with using most cooking techniques and preparing most foods was high. There were few socio-demographic differences in reported cooking skills. Adult cooking skills interventions are unlikely to have a large population impact, but may have important individual effects

  16. Effects of socio-demographic factors on parental monitoring, and regimen adherence among adolescents with type 1 diabetes: A moderation analysis.

    Science.gov (United States)

    Zhang, Liying; Ellis, Deborah A; Naar-King, Sylvie; Moltz, Kathleen; Carcone, April I; Dekelbab, Bassem

    2016-01-01

    Parental monitoring of adolescent diabetes care is an important predictor of adolescent regimen adherence. To date, no studies have investigated whether socio-demographic factors are associated with low levels of parental monitoring or differences in parental monitoring styles, and their moderating effects in families of adolescents with type 1 diabetes. The purpose of this cross-sectional study was to determine whether youth and family socio-demographic factors moderated the relationship between monitoring and youth regimen adherence (i.e., mean frequency of blood glucose testing [BGT]). Data were collected from 267 adolescents with type 1 diabetes and their parents. Hierarchical multiple regression analyses were employed. Socio-demographic factors accounted for 17.1% of the variance in adherence. After parental monitoring scales were entered, R(2) in all eight equations increased and R(2) change score in six of eight equations were significant. All models were significant after the interaction terms were entered. In the adolescent report models, parent age and family structure were both independently associated with adherence and also moderated the association between adolescent-report parental monitoring and adherence to diabetes care, in particular, adolescent report of parental direct observation/presence during diabetes care. In the parent report models, income was moderated the association between parent-report youth disclosure and adherence. Research should focus on identifying additional modifiable factors that place families at risk for low levels of parental monitoring of diabetes care. Future clinical research is needed to help identify risk factors for low levels of parental monitoring and develop interventions to promote optimal parenting skills that can support youth diabetes care.

  17. The geographic and demographic scope of shared sanitation: an analysis of national survey data from low- and middle-income countries.

    Science.gov (United States)

    Heijnen, Marieke; Rosa, Ghislaine; Fuller, James; Eisenberg, Joseph N S; Clasen, Thomas

    2014-11-01

    A large and growing proportion of the world's population rely on shared sanitation facilities that have historically been excluded from international targets due to concerns about acceptability, hygiene and access. In connection with a proposed change in such policy, we undertook this study to describe the prevalence and scope of households that report relying on shared sanitation and to characterise them in terms of selected socio-economic and demographic covariates. We extracted data from the most recent national household surveys of 84 low- and middle-income countries from Demographic and Health Surveys and Multiple Indicator Cluster Surveys. We describe the prevalence of shared sanitation and explore associations between specified covariates and reliance on shared sanitation using log-binomial regression. While household reliance on any type of shared sanitation is relatively rare in Europe (2.5%) and the Eastern Mediterranean (7.7%), it is not uncommon in the Americas (14.2%), Western Pacific (16.4%) and South-East Asia (31.3%), and it is most prevalent in Africa (44.6%) where many shared facilities do not meet the definition of 'improved' even if they were not shared (17.7%). Overall, shared sanitation is more common in urban (28.6%) than in rural settings (25.9%), even after adjusting for wealth. While results vary geographically, people who rely on shared sanitation tend to be poorer, reside in urban areas and live in households with more young children and headed by people with no formal education. Data from 21 countries suggest that most sharing is with neighbours and other acquaintances (82.0%) rather than the public. The determinants of shared sanitation identified from these data suggest potential confounders that may explain the apparent increased health risk from sharing and should be considered in any policy recommendation. Both geographic and demographic heterogeneity indicate the need for further research to support a change in policies. © 2014

  18. Global gene analysis of oocytes from early stages in human folliculogenesis shows high expression of novel genes in reproduction

    DEFF Research Database (Denmark)

    Markholt, Sara; Grøndahl, M L; Ernst, Erik

    2012-01-01

    The pool of primordial follicles in humans is laid down during embryonic development and follicles can remain dormant for prolonged intervals, often decades, until individual follicles resume growth. The mechanisms that induce growth and maturation of primordial follicles are poorly understood...... but follicles once activated either continue growth or undergo atresia. We have isolated pure populations of oocytes from human primordial, intermediate and primary follicles using laser capture micro-dissection microscopy and evaluated the global gene expression profiles by whole-genome microarray analysis...

  19. The shifting demographic landscape of pandemic influenza.

    Directory of Open Access Journals (Sweden)

    Shweta Bansal

    Full Text Available As Pandemic (H1N1 2009 influenza spreads around the globe, it strikes school-age children more often than adults. Although there is some evidence of pre-existing immunity among older adults, this alone may not explain the significant gap in age-specific infection rates.Based on a retrospective analysis of pandemic strains of influenza from the last century, we show that school-age children typically experience the highest attack rates in primarily naive populations, with the burden shifting to adults during the subsequent season. Using a parsimonious network-based mathematical model which incorporates the changing distribution of contacts in the susceptible population, we demonstrate that new pandemic strains of influenza are expected to shift the epidemiological landscape in exactly this way.Our analysis provides a simple demographic explanation for the age bias observed for H1N1/09 attack rates, and suggests that this bias may shift in coming months. These results have significant implications for the allocation of public health resources for H1N1/09 and future influenza pandemics.

  20. Global gene analysis of oocytes from early stages in human folliculogenesis shows high expression of novel genes in reproduction.

    Science.gov (United States)

    Markholt, S; Grøndahl, M L; Ernst, E H; Andersen, C Yding; Ernst, E; Lykke-Hartmann, K

    2012-02-01

    The pool of primordial follicles in humans is laid down during embryonic development and follicles can remain dormant for prolonged intervals, often decades, until individual follicles resume growth. The mechanisms that induce growth and maturation of primordial follicles are poorly understood but follicles once activated either continue growth or undergo atresia. We have isolated pure populations of oocytes from human primordial, intermediate and primary follicles using laser capture micro-dissection microscopy and evaluated the global gene expression profiles by whole-genome microarray analysis. The array data were confirmed by qPCR for selected genes. A total of 6301 unique genes were identified as significantly expressed representing enriched specific functional categories such as 'RNA binding', 'translation initiation' and 'structural molecule activity'. Several genes, some not previously known to be associated with early oocyte development, were identified with exceptionally high expression levels, such as the anti-proliferative transmembrane protein with an epidermal growth factor-like and two follistatin-like domains (TMEFF2), the Rho-GTPase-activating protein oligophrenin 1 (OPHN1) and the mitochondrial-encoded ATPase6 (ATP6). Thus, the present study provides not only a technique to capture and perform transcriptome analysis of the sparse material of human oocytes from the earliest follicle stages but further includes a comprehensive basis for our understanding of the regulatory factors and pathways present during early human folliculogenesis.

  1. Whole Genome Sequence and Phylogenetic Analysis Show Helicobacter pylori Strains from Latin America Have Followed a Unique Evolution Pathway

    Science.gov (United States)

    Muñoz-Ramírez, Zilia Y.; Mendez-Tenorio, Alfonso; Kato, Ikuko; Bravo, Maria M.; Rizzato, Cosmeri; Thorell, Kaisa; Torres, Roberto; Aviles-Jimenez, Francisco; Camorlinga, Margarita; Canzian, Federico; Torres, Javier

    2017-01-01

    Helicobacter pylori (HP) genetics may determine its clinical outcomes. Despite high prevalence of HP infection in Latin America (LA), there have been no phylogenetic studies in the region. We aimed to understand the structure of HP populations in LA mestizo individuals, where gastric cancer incidence remains high. The genome of 107 HP strains from Mexico, Nicaragua and Colombia were analyzed with 59 publicly available worldwide genomes. To study bacterial relationship on whole genome level we propose a virtual hybridization technique using thousands of high-entropy 13 bp DNA probes to generate fingerprints. Phylogenetic virtual genome fingerprint (VGF) was compared with Multi Locus Sequence Analysis (MLST) and with phylogenetic analyses of cagPAI virulence island sequences. With MLST some Nicaraguan and Mexican strains clustered close to Africa isolates, whereas European isolates were spread without clustering and intermingled with LA isolates. VGF analysis resulted in increased resolution of populations, separating European from LA strains. Furthermore, clusters with exclusively Colombian, Mexican, or Nicaraguan strains were observed, where the Colombian cluster separated from Europe, Asia, and Africa, while Nicaraguan and Mexican clades grouped close to Africa. In addition, a mixed large LA cluster including Mexican, Colombian, Nicaraguan, Peruvian, and Salvadorian strains was observed; all LA clusters separated from the Amerind clade. With cagPAI sequence analyses LA clades clearly separated from Europe, Asia and Amerind, and Colombian strains formed a single cluster. A NeighborNet analyses suggested frequent and recent recombination events particularly among LA strains. Results suggests that in the new world, H. pylori has evolved to fit mestizo LA populations, already 500 years after the Spanish colonization. This co-adaption may account for regional variability in gastric cancer risk. PMID:28293542

  2. Functional analysis of glycoside hydrolase family 8 xylanases shows narrow but distinct substrate specificities and biotechnological potential.

    Science.gov (United States)

    Pollet, Annick; Schoepe, Jan; Dornez, Emmie; Strelkov, Sergei V; Delcour, Jan A; Courtin, Christophe M

    2010-08-01

    The potential of glycoside hydrolase family (GH) 8 xylanases in biotechnological applications is virtually unexplored. Therefore, the substrate preference and hydrolysis product profiles of two GH8 xylanases were evaluated to investigate their activities and substrate specificities. A GH8 xylanase from an uncultured bacterium (rXyn8) shows endo action but very selectively releases xylotriose from its substrates. It has a higher activity than the Pseudoalteromonas haloplanktis GH8 endo-xylanase (PhXyl) on xylononaose and smaller xylo-oligosaccharides. PhXyl preferably degrades xylan substrates with a high degree of polymerization. It is sterically more hindered by arabinose substituents than rXyn8, producing larger end hydrolysis products. The specificities of rXyn8 and PhXyl differ completely from these of the previously described GH8 xylanases from Bifidobacterium adolescentis (BaRexA) and Bacillus halodurans (BhRex). As reducing-end xylose-releasing exo-oligoxylanases, they selectively release xylose from the reducing end of small xylo-oligosaccharides. The findings of this study show that GH8 xylanases have a narrow substrate specificity, but also one that strongly varies between family members and is distinct from that of GH10 and GH11 xylanases. Structural comparison of rXyn8, PhXyl, BaRexA, and BhRex showed that subtle amino acid changes in the glycon as well as the aglycon subsites probably form the basis of the observed differences between GH8 xylanases. GH8 xylanases, therefore, are an interesting group of enzymes, with potential towards engineering and applications.

  3. Transcriptomic and metabolomic analysis of Yukon Thellungiella plants grown in cabinets and their natural habitat show phenotypic plasticity

    Directory of Open Access Journals (Sweden)

    Guevara David R

    2012-10-01

    Full Text Available Abstract Background Thellungiella salsuginea is an important model plant due to its natural tolerance to abiotic stresses including salt, cold, and water deficits. Microarray and metabolite profiling have shown that Thellungiella undergoes stress-responsive changes in transcript and organic solute abundance when grown under controlled environmental conditions. However, few reports assess the capacity of plants to display stress-responsive traits in natural habitats where concurrent stresses are the norm. Results To determine whether stress-responsive changes observed in cabinet-grown plants are recapitulated in the field, we analyzed leaf transcript and metabolic profiles of Thellungiella growing in its native Yukon habitat during two years of contrasting meteorological conditions. We found 673 genes showing differential expression between field and unstressed, chamber-grown plants. There were comparatively few overlaps between genes expressed under field and cabinet treatment-specific conditions. Only 20 of 99 drought-responsive genes were expressed both in the field during a year of low precipitation and in plants subjected to drought treatments in cabinets. There was also a general pattern of lower abundance among metabolites found in field plants relative to control or stress-treated plants in growth cabinets. Nutrient availability may explain some of the observed differences. For example, proline accumulated to high levels in cold and salt-stressed cabinet-grown plants but proline content was, by comparison, negligible in plants at a saline Yukon field site. We show that proline accumulated in a stress-responsive manner in Thellungiella plants salinized in growth cabinets and in salt-stressed seedlings when nitrogen was provided at 1.0 mM. In seedlings grown on 0.1 mM nitrogen medium, the proline content was low while carbohydrates increased. The relatively higher content of sugar-like compounds in field plants and seedlings on low nitrogen

  4. Highlighting the Socio-Demographic Differences of the Key Determinants of Staff’s Satisfaction in Jordanian Hospitals. An Empirical Analysis Based on Warr-Cool-Wall Scales

    Directory of Open Access Journals (Sweden)

    Adriana AnaMaria DAVIDESCU

    2016-12-01

    Full Text Available The aim of this paper is to highlight the socio-demographic differences regarding the main determinants of employee satisfaction in Jordanian hospitals using a sample of 325 employees from six different hospitals in 2015. Therefore, it has been used Warr-Cook-Wall scale in order to assess job satisfaction according to four dimensions: extrinsic job satisfaction, intrinsic job satisfaction, working conditions satisfaction, employee relations satisfaction. The socio-demographic differences on the job satisfaction factors were analyzed using t-test, Anova test and correlation coefficients. The empirical results pointed out that young and older employees express higher degrees of satisfaction comparative with other age group regarding the extrinsic satisfaction and employee relations and that administrative staff, helpers and doctors are more satisfied intrinsic satisfaction, extrinsic satisfaction, working conditions, employee relations and also on the overall level of satisfaction. Also individuals from horizontal structure exhibit higher levels of satisfaction regarding the job satisfaction factors than the ones from vertical structure.

  5. Food insecurity and socio-demographic characteristics in two UK ethnic groups: an analysis of women in the Born in Bradford cohort.

    Science.gov (United States)

    Power, Madeleine; Uphoff, Eleonora P; Stewart-Knox, Barbara; Small, Neil; Doherty, Bob; Pickett, Kate E

    2017-03-28

    The use of foodbanks has risen sharply in the UK; however, the epidemiology of UK food insecurity is undeveloped. This study contributes to the field by analysing socio-demographic risk factors for food insecurity in a female, ethnically diverse population. Data from the Born in Bradford (BiB) cohort were matched with data on food insecurity from the nested BiB1000 study (N = 1280). Logistic regression was used to model food insecurity in relation to ethnicity and socio-demographic factors. Food insecurity, reported by 13.98% of the sample, was more likely among White British than Pakistani women (crude Odds Ratio (OR) 1.94, 95% CI: 1.37; 2.74, adjusted OR 2.37, 95% CI: 1.57; 3.59). In fully adjusted analyses, food insecurity was associated with a range of socio-economic measures, particularly the receipt of mean-tested benefits (adjusted OR 2.11, 95% CI: 1.41; 3.15) and perception of financial insecurity (adjusted OR 8.91, 95% CI: 4.14; 19.16 for finding it difficult/very difficult compared to living comfortably). The finding that food insecurity prevalence may be higher than previously thought and that food insecurity is highly associated with socio-economic status, notably benefit receipt, is a cause for concern necessitating an urgent policy response.

  6. Mutational analysis of sclerostin shows importance of the flexible loop and the cystine-knot for Wnt-signaling inhibition.

    Science.gov (United States)

    Boschert, Verena; van Dinther, Maarten; Weidauer, Stella; van Pee, Katharina; Muth, Eva-Maria; Ten Dijke, Peter; Mueller, Thomas D

    2013-01-01

    The cystine-knot containing protein Sclerostin is an important negative regulator of bone growth and therefore represents a promising therapeutic target. It exerts its biological task by inhibiting the Wnt (wingless and int1) signaling pathway, which participates in bone formation by promoting the differentiation of mesenchymal stem cells to osteoblasts. The core structure of Sclerostin consists of three loops with the first and third loop (Finger 1 and Finger 2) forming a structured β-sheet and the second loop being unstructured and highly flexible. Biochemical data showed that the flexible loop is important for binding of Sclerostin to Wnt co-receptors of the low-density lipoprotein related-protein family (LRP), by interacting with the Wnt co-receptors LRP5 or -6 it inhibits Wnt signaling. To further examine the structural requirements for Wnt inhibition, we performed an extensive mutational study within all three loops of the Sclerostin core domain involving single and multiple mutations as well as truncation of important regions. By this approach we could confirm the importance of the second loop and especially of amino acids Asn92 and Ile94 for binding to LRP6. Based on a Sclerostin variant found in a Turkish family suffering from Sclerosteosis we generated a Sclerostin mutant with cysteines 84 and 142 exchanged thereby removing the third disulfide bond of the cystine-knot. This mutant binds to LRP6 with reduced binding affinity and also exhibits a strongly reduced inhibitory activity against Wnt1 thereby showing that also elements outside the flexible loop are important for inhibition of Wnt by Sclerostin. Additionally, we examined the effect of the mutations on the inhibition of two different Wnt proteins, Wnt3a and Wnt1. We could detect clear differences in the inhibition of these proteins, suggesting that the mechanism by which Sclerostin antagonizes Wnt1 and Wnt3a is fundamentally different.

  7. Mutational analysis of sclerostin shows importance of the flexible loop and the cystine-knot for Wnt-signaling inhibition.

    Directory of Open Access Journals (Sweden)

    Verena Boschert

    Full Text Available The cystine-knot containing protein Sclerostin is an important negative regulator of bone growth and therefore represents a promising therapeutic target. It exerts its biological task by inhibiting the Wnt (wingless and int1 signaling pathway, which participates in bone formation by promoting the differentiation of mesenchymal stem cells to osteoblasts. The core structure of Sclerostin consists of three loops with the first and third loop (Finger 1 and Finger 2 forming a structured β-sheet and the second loop being unstructured and highly flexible. Biochemical data showed that the flexible loop is important for binding of Sclerostin to Wnt co-receptors of the low-density lipoprotein related-protein family (LRP, by interacting with the Wnt co-receptors LRP5 or -6 it inhibits Wnt signaling. To further examine the structural requirements for Wnt inhibition, we performed an extensive mutational study within all three loops of the Sclerostin core domain involving single and multiple mutations as well as truncation of important regions. By this approach we could confirm the importance of the second loop and especially of amino acids Asn92 and Ile94 for binding to LRP6. Based on a Sclerostin variant found in a Turkish family suffering from Sclerosteosis we generated a Sclerostin mutant with cysteines 84 and 142 exchanged thereby removing the third disulfide bond of the cystine-knot. This mutant binds to LRP6 with reduced binding affinity and also exhibits a strongly reduced inhibitory activity against Wnt1 thereby showing that also elements outside the flexible loop are important for inhibition of Wnt by Sclerostin. Additionally, we examined the effect of the mutations on the inhibition of two different Wnt proteins, Wnt3a and Wnt1. We could detect clear differences in the inhibition of these proteins, suggesting that the mechanism by which Sclerostin antagonizes Wnt1 and Wnt3a is fundamentally different.

  8. Anatomical network analysis shows decoupling of modular lability and complexity in the evolution of the primate skull.

    Directory of Open Access Journals (Sweden)

    Borja Esteve-Altava

    Full Text Available Modularity and complexity go hand in hand in the evolution of the skull of primates. Because analyses of these two parameters often use different approaches, we do not know yet how modularity evolves within, or as a consequence of, an also-evolving complex organization. Here we use a novel network theory-based approach (Anatomical Network Analysis to assess how the organization of skull bones constrains the co-evolution of modularity and complexity among primates. We used the pattern of bone contacts modeled as networks to identify connectivity modules and quantify morphological complexity. We analyzed whether modularity and complexity evolved coordinately in the skull of primates. Specifically, we tested Herbert Simon's general theory of near-decomposability, which states that modularity promotes the evolution of complexity. We found that the skulls of extant primates divide into one conserved cranial module and up to three labile facial modules, whose composition varies among primates. Despite changes in modularity, statistical analyses reject a positive feedback between modularity and complexity. Our results suggest a decoupling of complexity and modularity that translates to varying levels of constraint on the morphological evolvability of the primate skull. This study has methodological and conceptual implications for grasping the constraints that underlie the developmental and functional integration of the skull of humans and other primates.

  9. Phylogenetic analysis shows that Neolithic slate plaques from the southwestern Iberian Peninsula are not genealogical recording systems.

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    Daniel García Rivero

    Full Text Available Prehistoric material culture proposed to be symbolic in nature has been the object of considerable archaeological work from diverse theoretical perspectives, yet rarely are methodological tools used to test the interpretations. The lack of testing is often justified by invoking the opinion that the slippery nature of past human symbolism cannot easily be tackled by the scientific method. One such case, from the southwestern Iberian Peninsula, involves engraved stone plaques from megalithic funerary monuments dating ca. 3,500-2,750 B.C. (calibrated age. One widely accepted proposal is that the plaques are ancient mnemonic devices that record genealogies. The analysis reported here demonstrates that this is not the case, even when the most supportive data and techniques are used. Rather, we suspect there was a common ideological background to the use of plaques that overlay the southwestern Iberian Peninsula, with little or no geographic patterning. This would entail a cultural system in which plaque design was based on a fundamental core idea, with a number of mutable and variable elements surrounding it.

  10. Phylogenetic analysis shows that Neolithic slate plaques from the southwestern Iberian Peninsula are not genealogical recording systems.

    Science.gov (United States)

    García Rivero, Daniel; O'Brien, Michael J

    2014-01-01

    Prehistoric material culture proposed to be symbolic in nature has been the object of considerable archaeological work from diverse theoretical perspectives, yet rarely are methodological tools used to test the interpretations. The lack of testing is often justified by invoking the opinion that the slippery nature of past human symbolism cannot easily be tackled by the scientific method. One such case, from the southwestern Iberian Peninsula, involves engraved stone plaques from megalithic funerary monuments dating ca. 3,500-2,750 B.C. (calibrated age). One widely accepted proposal is that the plaques are ancient mnemonic devices that record genealogies. The analysis reported here demonstrates that this is not the case, even when the most supportive data and techniques are used. Rather, we suspect there was a common ideological background to the use of plaques that overlay the southwestern Iberian Peninsula, with little or no geographic patterning. This would entail a cultural system in which plaque design was based on a fundamental core idea, with a number of mutable and variable elements surrounding it.

  11. Selection Indices and Multivariate Analysis Show Similar Results in the Evaluation of Growth and Carcass Traits in Beef Cattle.

    Science.gov (United States)

    Brito Lopes, Fernando; da Silva, Marcelo Corrêa; Magnabosco, Cláudio Ulhôa; Goncalves Narciso, Marcelo; Sainz, Roberto Daniel

    2016-01-01

    This research evaluated a multivariate approach as an alternative tool for the purpose of selection regarding expected progeny differences (EPDs). Data were fitted using a multi-trait model and consisted of growth traits (birth weight and weights at 120, 210, 365 and 450 days of age) and carcass traits (longissimus muscle area (LMA), back-fat thickness (BF), and rump fat thickness (RF)), registered over 21 years in extensive breeding systems of Polled Nellore cattle in Brazil. Multivariate analyses were performed using standardized (zero mean and unit variance) EPDs. The k mean method revealed that the best fit of data occurred using three clusters (k = 3) (P multivariate index (LD1) were moderate to high, ranging from 0.48 to 0.97. This reveals that both types of indices give similar results and that the multivariate approach is reliable for the purpose of selection. The alternative tool seems very handy when economic weights are not available or in cases where more rapid identification of the best animals is desired. Interestingly, multivariate analysis allowed forecasting information based on the relationships among breeding values (EPDs). Also, it enabled fine discrimination, rapid data summarization after genetic evaluation, and permitted accounting for maternal ability and the genetic direct potential of the animals. In addition, we recommend the use of longissimus muscle area and subcutaneous fat thickness as selection criteria, to allow estimation of breeding values before the first mating season in order to accelerate the response to individual selection.

  12. Design-around biotechnology patents: an analysis of US Federal Circuit decisions shows the possibility of designing around biotechnology patents.

    Science.gov (United States)

    Wang, Shyh-Jen

    2011-01-01

    In order to demonstrate the possibility of design-around for patents, we reviewed 40 no-infringement cases out of all 4,760 Federal Circuit Court of Appeals (CAFC) cases decided from 2001 to 2009. Based on this analysis, designing around a biotechnology patent first requires a thorough reading of the patent specification and prosecution history. These written descriptions offer explicit directions about claim meanings or the scope being disclaimed. By statute, claims recite and define the structure or acts of an invention, and serve as tools to determine whether or not a patent is infringed. The next procedure would include omitting a part or property from the claim, reversing the action used in the claim, or changing the claim's structure or range to prevent the new design from falling within the scope of the claim. However, cases where patent infringement was found demonstrated that changing the structure or range not recited in the claim, such as enlarging the diameter, reducing concentration or alerting the shape, still falls within the scope of the patent. Although the 40 cases analyzed in this study were not related to vaccines, the thought process can serve as a guideline for patents related to vaccine development.

  13. Analysis of HCV genotypes from blood donors shows three new HCV type 6 subgroups exist in Myanmar.

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    Shinji T

    2004-06-01

    Full Text Available The prevalence of hepatitis C virus (HCV genotypes in Myanmar in comparison with the rest of Southeast Asia is not well known. Serum samples were obtained from 201 HCV antibody-positive volunteer blood donors in and around the Myanmar city of Yangon. Of these, the antibody titers of 101 samples were checked by serial dilution using HCV antibody PA test II and Terasaki microplate as a low-cost method. To compare antibody titers by this method and RNA identification, we also checked HCV-RNA using the Amplicor 2.0 test. Most high-titer groups were positive for HCV-RNA. Of the 201 samples, 110 were successfully polymerase chain reaction (PCR amplified. Among them, 35 (31.8% were of genotype 1, 52 (47.3% were of genotype 3, and 23 (20.9% were of type 6 variants, and phylogenetic analysis of these type 6 variants revealed that 3 new type 6 subgroups exist in Myanmar. We named the subgroups M6-1, M6-2, and M6-3. M6-1 and M6-2 were relatively close to types 8 and 9, respectively. M6-3, though only found in one sample, was a brand-new subgroup. These subtypes were not seen in Vietnam, where type 6 group variants are widely spread. These findings may be useful for analyzing how and when these subgroups were formed.

  14. Morphometric analysis of molars in a Middle Pleistocene population shows a mosaic of 'modern' and Neanderthal features.

    Science.gov (United States)

    Martinón-Torres, María; Spěváčková, Petra; Gracia-Téllez, Ana; Martínez, Ignacio; Bruner, Emiliano; Arsuaga, Juan Luis; Bermúdez de Castro, José María

    2013-10-01

    Previous studies of upper first molar (M1) crown shape have shown significant differences between Homo sapiens and Homo neanderthalensis that were already present in the European Middle Pleistocene populations, including the large dental sample from Atapuerca-Sima de los Huesos (SH). Analysis of other M1 features such as the total crown base area, cusp proportions, cusp angles and occlusal polygon have confirmed the differences between both lineages, becoming a useful tool for the taxonomic assignment of isolated teeth from Late Pleistocene sites. However, until now the pattern of expression of these variables has not been known for the SH sample. This fossil sample, the largest collection from the European Middle Pleistocene, is generally interpreted as being from the direct ancestors of Neanderthals, and thus is a reference sample for assessing the origin of the Neanderthal morphologies. Surprisingly, our study reveals that SH M(1) s present a unique mosaic of H. neanderthalensis and H. sapiens features. Regarding the cusp angles and the relative occlusal polygon area, SH matches the H. neanderthalensis pattern. However, regarding the total crown base area and relative cusps size, SH M(1) s are similar to H. sapiens, with a small crown area, a strong hypocone reduction and a protocone enlargement, although the protocone expansion in SH is significantly larger than in any other group studied. The SH dental sample calls into question the uniqueness of some so-called modern traits. Our study also sounds a note of caution on the use of M(1) occlusal morphology for the alpha taxonomy of isolated M(1) s.

  15. Genetic analysis shows that morphology alone cannot distinguish asian carp eggs from those of other cyprinid species

    Science.gov (United States)

    Larson, James H.; McCalla, Sunnie; Chapman, Duane C.; Rees, Christopher B.; Knights, Brent C.; Vallazza, Jon; George, Amy E.; Richardson, William B.; Amberg, Jon

    2016-01-01

    Fish eggs and embryos (hereafter collectively referred to as “eggs”) were collected in the upper Mississippi River main stem (~300 km upstream of previously reported spawning by invasive Asian carp) during summer 2013. Based on previously published morphological characteristics, the eggs were identified as belonging to Asian carp. A subsample of the eggs was subsequently analyzed by using molecular methods to determine species identity. Genetic identification using the cytochrome-c oxidase 1 gene was attempted for a total of 41 eggs. Due to the preservation technique used (formalin) and the resulting DNA degradation, sequences were recovered from only 17 individual eggs. In all 17 cases, cyprinids other than Asian carp (usually Notropis sp.) were identified as the most likely species. In previously published reports, a key characteristic that distinguished Asian carp eggs from those of other cyprinids was size: Asian carp eggs exhibited diameters ranging from 4.0 to 6.0 mm and were thought to be much larger than the otherwise similar eggs of native species. Eggs from endemic cyprinids were believed to rarely reach 3.0 mm and had not been observed to exceed 3.3 mm. However, many of the eggs that were genetically identified as originating from native cyprinids were as large as 4.0 mm in diameter (at early developmental stages) and were therefore large enough to over- lap with the lower end of the size range observed for Asian carp eggs. Researchers studying the egg stages of Asian carp and other cyprinids should plan on preserving subsets of eggs for genetic analysis to confirm morphological identifications.

  16. Selection Indices and Multivariate Analysis Show Similar Results in the Evaluation of Growth and Carcass Traits in Beef Cattle.

    Directory of Open Access Journals (Sweden)

    Fernando Brito Lopes

    Full Text Available This research evaluated a multivariate approach as an alternative tool for the purpose of selection regarding expected progeny differences (EPDs. Data were fitted using a multi-trait model and consisted of growth traits (birth weight and weights at 120, 210, 365 and 450 days of age and carcass traits (longissimus muscle area (LMA, back-fat thickness (BF, and rump fat thickness (RF, registered over 21 years in extensive breeding systems of Polled Nellore cattle in Brazil. Multivariate analyses were performed using standardized (zero mean and unit variance EPDs. The k mean method revealed that the best fit of data occurred using three clusters (k = 3 (P < 0.001. Estimates of genetic correlation among growth and carcass traits and the estimates of heritability were moderate to high, suggesting that a correlated response approach is suitable for practical decision making. Estimates of correlation between selection indices and the multivariate index (LD1 were moderate to high, ranging from 0.48 to 0.97. This reveals that both types of indices give similar results and that the multivariate approach is reliable for the purpose of selection. The alternative tool seems very handy when economic weights are not available or in cases where more rapid identification of the best animals is desired. Interestingly, multivariate analysis allowed forecasting information based on the relationships among breeding values (EPDs. Also, it enabled fine discrimination, rapid data summarization after genetic evaluation, and permitted accounting for maternal ability and the genetic direct potential of the animals. In addition, we recommend the use of longissimus muscle area and subcutaneous fat thickness as selection criteria, to allow estimation of breeding values before the first mating season in order to accelerate the response to individual selection.

  17. Morphometric analysis of molars in a Middle Pleistocene population shows a mosaic of ‘modern’ and Neanderthal features

    Science.gov (United States)

    Martinón-Torres, María; Spěváčková, Petra; Gracia-Téllez, Ana; Martínez, Ignacio; Bruner, Emiliano; Arsuaga, Juan Luis; Bermúdez de Castro, José María

    2013-01-01

    Previous studies of upper first molar (M1) crown shape have shown significant differences between Homo sapiens and Homo neanderthalensis that were already present in the European Middle Pleistocene populations, including the large dental sample from Atapuerca-Sima de los Huesos (SH). Analysis of other M1 features such as the total crown base area, cusp proportions, cusp angles and occlusal polygon have confirmed the differences between both lineages, becoming a useful tool for the taxonomic assignment of isolated teeth from Late Pleistocene sites. However, until now the pattern of expression of these variables has not been known for the SH sample. This fossil sample, the largest collection from the European Middle Pleistocene, is generally interpreted as being from the direct ancestors of Neanderthals, and thus is a reference sample for assessing the origin of the Neanderthal morphologies. Surprisingly, our study reveals that SH M1s present a unique mosaic of H. neanderthalensis and H. sapiens features. Regarding the cusp angles and the relative occlusal polygon area, SH matches the H. neanderthalensis pattern. However, regarding the total crown base area and relative cusps size, SH M1s are similar to H. sapiens, with a small crown area, a strong hypocone reduction and a protocone enlargement, although the protocone expansion in SH is significantly larger than in any other group studied. The SH dental sample calls into question the uniqueness of some so-called modern traits. Our study also sounds a note of caution on the use of M1 occlusal morphology for the alpha taxonomy of isolated M1s. PMID:23914934

  18. Comparative genomic hybridization analysis shows different epidemiology of chromosomal and plasmid-borne cpe-carrying Clostridium perfringens type A.

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    Päivi Lahti

    Full Text Available Clostridium perfringens, one of the most common causes of food poisonings, can carry the enterotoxin gene, cpe, in its chromosome or on a plasmid. C. perfringens food poisonings are more frequently caused by the chromosomal cpe-carrying strains, while the plasmid-borne cpe-positive genotypes are more commonly found in the human feces and environmental samples. Different tolerance to food processing conditions by the plasmid-borne and chromosomal cpe-carrying strains has been reported, but the reservoirs and contamination routes of enterotoxin-producing C. perfringens remain unknown. A comparative genomic hybridization (CGH analysis with a DNA microarray based on three C. perfringens type A genomes was conducted to shed light on the epidemiology of C. perfringens food poisonings caused by plasmid-borne and chromosomal cpe-carrying strains by comparing chromosomal and plasmid-borne cpe-positive and cpe-negative C. perfringens isolates from human, animal, environmental, and food samples. The chromosomal and plasmid-borne cpe-positive C. perfringens genotypes formed two distinct clusters. Variable genes were involved with myo-inositol, ethanolamine and cellobiose metabolism, suggesting a new epidemiological model for C. perfringens food poisonings. The CGH results were complemented with growth studies, which demonstrated different myo-inositol, ethanolamine, and cellobiose metabolism between the chromosomal and plasmid-borne cpe-carrying strains. These findings support a ubiquitous occurrence of the plasmid-borne cpe-positive strains and their adaptation to the mammalian intestine, whereas the chromosomal cpe-positive strains appear to have a narrow niche in environments containing degrading plant material. Thus the epidemiology of the food poisonings caused by two populations appears different, the plasmid-borne cpe-positive strains probably contaminating foods via humans and the chromosomal strains being connected to plant material.

  19. An actuarial analysis shows that offering lung cancer screening as an insurance benefit would save lives at relatively low cost.

    Science.gov (United States)

    Pyenson, Bruce S; Sander, Marcia S; Jiang, Yiding; Kahn, Howard; Mulshine, James L

    2012-04-01

    Lung cancer screening is not established as a public health practice, yet the results of a recent large randomized controlled trial showed that screening with low-dose spiral computed tomography reduces lung cancer mortality. Using actuarial models, this study estimated the costs and benefits of annual lung cancer screening offered as a commercial insurance benefit in the high-risk US population ages 50-64. Assuming current commercial reimbursement rates for treatment, we found that screening would cost about $1 per insured member per month in 2012 dollars. The cost per life-year saved would be below $19,000, an amount that compares favorably with screening for cervical, breast, and colorectal cancers. Our results suggest that commercial insurers should consider lung cancer screening of high-risk individuals to be high-value coverage and provide it as a benefit to people who are at least fifty years old and have a smoking history of thirty pack-years or more. We also believe that payers and patients should demand screening from high-quality, low-cost providers, thus helping set an example of efficient system innovation.

  20. X-ray survival characteristics and genetic analysis for nine saccharomyces deletion mutants that show altered radiation sensitivity

    Energy Technology Data Exchange (ETDEWEB)

    Game, John C.; Williamson, Marsha S.; Baccari, Clelia

    2004-01-07

    The availability of a genome-wide set of Saccharomyces deletion mutants provides a chance to identify all the yeast genes involved in DNA repair. Using X-rays, we are screening these mutants to identify additional genes that show increased sensitivity to the lethal effects of ionizing radiation. For each mutant identified as sensitive, we are confirming that the sensitivity phenotype co-segregates with the deletion allele and are obtaining multipoint survival-versus-dose assays in at least two haploid and one homozygous diploid strains. We present data for deletion mutants involving the genes DOT1, MDM20, NAT3, SPT7, SPT20, GCN5, HFI1, DCC1 and VID21/EAF1, and discuss their potential roles in repair. Eight of these genes have a clear radiation-sensitive phenotype when deleted, but the ninth, GCN5, has at most a borderline phenotype. None of the deletions confer substantial sensitivity to ultra-violet radiation, although one or two may confer marginal sensitivity. The DOT1 gene is of interest because its only known function is to methylate one lysine residue in the core of the histone H3 protein. We find that histone H3 mutants (supplied by K. Struhl) in which this residue is replaced by other amino-acids are also X-ray sensitive, seeming to confirm that methylation of the lysine-79 residue is required for effective repair of radiation damage.

  1. Comprehensive behavioral analysis of Ox1r-/- mice showed implication of orexin receptor-1 in mood, anxiety and social behavior

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    Md Golam Abbas

    2015-12-01

    Full Text Available Neuropeptides orexin A and orexin B, which are exclusively produced by neurons in the lateral hypothalamic area, play an important role in the regulation of a wide range of behaviors and homeostatic processes, including regulation of sleep/wakefulness states and energy homeostasis. The orexin system has close anatomical and functional relationships with systems that regulate the autonomic nervous system, emotion, mood, the reward system and sleep/wakefulness states. Recent pharmacological studies using selective antagonists have suggested that orexin receptor-1 (OX1R is involved in physiological processes that regulate emotion, the reward system and autonomic nervous system. Here, we examined Ox1r-/- mice with a comprehensive behavioral test battery to screen additional OX1R functions. Ox1r-/- mice showed increased anxiety-like behavior, altered depression-like behavior, slightly decreased spontaneous locomotor activity, reduced social interaction, increased startle response and decreased prepulse inhibition. These results suggest that OX1R plays roles in social behaviour and sensory motor gating in addition to roles in mood and anxiety.

  2. What limits the utilization of health services among china labor force? analysis of inequalities in demographic, socio-economic and health status.

    Science.gov (United States)

    Lu, Liming; Zeng, Jingchun; Zeng, Zhi

    2017-02-02

    Inequalities in demographic, socio-economic and health status for China labor force place them at greater health risks, and marginalized them in the utilization of healthcare services. This paper identifies the inequalities which limit the utilization of health services among China labor force, and provides a reference point for health policy. Data were collected from 23,505 participants aged 15 to 65, from the 2014 China Labor Force Dynamic Survey (a nationwide cross-sectional survey covering 29 provinces with a multi-stage cluster, and stratified, probability sampling strategy) conducted by Sun Yat-sen University. Logistic regression models were used to study the effects of demographic (age, gender, marital status, type of hukou and migration status), socio-economic (education, social class and insurance) and health status (self-perceived general health and several chronic illnesses) variables on the utilization of health services (two-week visiting and hospitalization during the past 12 months). Goodness of fit was assessed using Hosmer-Lemeshow test. Discrimination ability was assessed based on the area under the receiver operating curve (AUC). Migrants with more than 1 (OR 2.80, 95% CI 1.01 ~ 7.82) or none chronic illnesses (OR 1.26, 95% CI 1.01 ~ 7.82) are more likely to be two week visiting to the clinic than non-migrants; migrants with none chronic illnesses (OR 0.61, 95% CI 0.45 ~ 0.82) are less likely to be in hospitalization during the past 12 months than non-migrants. Female, elder, hukou of non-agriculture, higher education level, higher social class, purchasing more insurance and poorer self-perceived health were predictors for more utilization of health service. More insurance benefited more two-week visiting (OR 1.12, 95% CI 1.06 ~ 1.17) and hospitalization during the past 12 months (OR 1.12, 95% CI 1.07 ~ 1.18) for individuals with none chronic illness but not ≥1 chronic illnesses. All models achieved good calibration

  3. Transcriptome analysis of Enterococcus faecalis during mammalian infection shows cells undergo adaptation and exist in a stringent response state.

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    Kristi L Frank

    Full Text Available As both a commensal and a major cause of healthcare-associated infections in humans, Enterococcus faecalis is a remarkably adaptable organism. We investigated how E. faecalis adapts in a mammalian host as a pathogen by characterizing changes in the transcriptome during infection in a rabbit model of subdermal abscess formation using transcriptional microarrays. The microarray experiments detected 222 and 291 differentially regulated genes in E. faecalis OG1RF at two and eight hours after subdermal chamber inoculation, respectively. The profile of significantly regulated genes at two hours post-inoculation included genes involved in stress response, metabolism, nutrient acquisition, and cell surface components, suggesting genome-wide adaptation to growth in an altered environment. At eight hours post-inoculation, 88% of the differentially expressed genes were down-regulated and matched a transcriptional profile consistent with a (pppGpp-mediated stringent response. Subsequent subdermal abscess infections with E. faecalis mutants lacking the (pppGpp synthetase/hydrolase RSH, the small synthetase RelQ, or both enzymes, suggest that intracellular (pppGpp levels, but not stringent response activation, influence persistence in the model. The ability of cells to synthesize (pppGpp was also found to be important for growth in human serum and whole blood. The data presented in this report provide the first genome-wide insights on E. faecalis in vivo gene expression and regulation measured by transcriptional profiling during infection in a mammalian host and show that (pppGpp levels affect viability of E. faecalis in multiple conditions relevant to mammalian infection. The subdermal abscess model can serve as a novel experimental system for studying the E. faecalis stringent response in the context of the mammalian immune system.

  4. Demographic Factors Affecting Internet Using Purposes of High School Students

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    Abdullah Faruk Kılıç

    2017-01-01

    Full Text Available This study aimed at determining the impact of demographic factors on the Internet usage purposes of high school students. The population of the study consisted of students between 9th and 12th grades from the Anatolian high schools, science high schools, social sciences high schools, sports high schools and fine arts high schools in Turkey. The sample was chosen through the stratified and cluster sampling procedure. The students were chosen randomly depending on the regions of their school attendance. The sample for this research numbered 3170 students. The research was conducted in the second term of the 2014-2015 academic year. The data were obtained through online forms and the bases of participation are honesty, sincerity, and volunteerism. The data collection tool is a questionnaire and a demographic information form prepared by the researchers. Chi-square Automatic Interaction Detector (CHAID analysis was conducted through SPSS in order to determine the demographic factors affecting the purposes of internet usage among high school students. The results of this research show that 9th grade students in Turkey mostly use the Internet to do homework while students from other grades mostly use the Internet for social networking. The male students use the Internet for playing video games more frequently in comparison with female students. Also, socioeconomic status affects the purpose of Internet usage. Hence it is suggested that teachers talking to male students might use the examples of computers and games and with female students they might relate the topics to social media.

  5. EJSCREEN Demographic Indicators 2016 Public

    Data.gov (United States)

    U.S. Environmental Protection Agency — EJSCREEN uses demographic factors as very general indicators of a community's potential susceptibility to the types of environmental factors included in this...

  6. EJSCREEN Demographic Indicators 2015 Internal

    Data.gov (United States)

    U.S. Environmental Protection Agency — EJSCREEN uses demographic factors as very general indicators of a community's potential susceptibility to the types of environmental factors included in this...

  7. EJSCREEN Demographic Indicators 2015 Public

    Data.gov (United States)

    U.S. Environmental Protection Agency — EJSCREEN uses demographic factors as very general indicators of a community's potential susceptibility to the types of environmental factors included in this...

  8. Does Cognitive Behavior Therapy for Psychosis (CBTp show a sustainable effect on delusions? A meta-analysis.

    Directory of Open Access Journals (Sweden)

    Stephanie eMehl

    2015-10-01

    Full Text Available Cognitive Behavior Therapy for psychosis (CBTp is an effective treatment resulting in small to medium effect sizes with regard to changes in positive symptoms and psychopathology. As a consequence, CBTp is recommended by national guidelines for all patients with schizophrenia. However, although CBTp was originally developed as a means to improve delusions, meta-analyses have generally integrated effects for positive symptoms rather than for delusions. Thus, it is still an open question whether more broadly defined CBTp is more effective with regard to change in delusions compared to treatment as usual (TAU and to other interventions, and whether this effect remains stable over a follow-up period. Moreover, it would be interesting to explore whether newer studies that focus on specific factors involved in the formation and maintenance of delusions (causal-interventionist approach are more effective than the first generation of CBTp studies. A systematic search of the trial literature identified 19 RCTs that compared CBTp with TAU and/or other interventions and reported delusions as an outcome measure. Meta-analytic integration resulted in a significant small to medium effect size for CBTp in comparison to TAU at end-of-therapy (k=13; d ̅=0.27 and after an average follow-up period of 47 weeks (k=12; d ̅=0.25. When compared with other interventions, there was no significant effect of CBTp at end-of-therapy (k=8; d ̅=0.16 and after a follow-up period (k=5; d ̅=–0.04. Comparison between newer studies taking a causal-interventionist approach (k=4 and first-generation studies showed a difference of 0.33 in mean effect sizes in favor of newer studies at end-of-therapy. The findings suggest that CBTp is superior to TAU, but is not superior to other interventions, in bringing about a change in delusions, and that this superiority is maintained over the follow-up period. Moreover, interventions that focus on causal factors of delusions seem to be a

  9. Association between biomass fuel use and maternal report of child size at birth - an analysis of 2005-06 India Demographic Health Survey data

    Directory of Open Access Journals (Sweden)

    Sathiakumar Nalini

    2011-05-01

    Full Text Available Background Observational epidemiological studies and a systematic review have consistently shown an association between maternal exposure to biomass smoke and reduced birth weight. Our aim was to further test this hypothesis. Methods We analysed the data from 47,139 most recent singleton births during preceding five years of 2005-06 India Demographic Health Survey (DHS. Information about birth weight from child health card and/or mothers' recall was analysed. Since birth weight was not recorded for nearly 60% of the reported births, maternal self-report of child's size at birth was used as a proxy. Fuel type was classified as high pollution fuels (wood, straw, animal dung, and crop residues kerosene, coal and charcoal, and low pollution fuels (electricity, liquid petroleum gas (LPG, natural gas and biogas. Univariate and multivariable logistic regression models were developed using SURVEYLOGISTIC procedure in SAS system. We used three logistic regression models in which child factors, maternal factors and demographic factors were added step-by-step to the main exposure variable. Adjusted Odds Ratios (AORs and their 95% CI were calculated. A p-value less than 0.05 was considered as significant. Results Child's birth weight was available for only 19,270 (41% births; 3113 from health card and 16,157 from mothers' recall. For available data, mean birth weight was 2846.5 grams (SD = 684.6. Children born in households using high pollution fuels were 73 grams lighter than those born in households using low pollution fuels (mean birth weight 2883.8 grams versus 2810.7 grams, p Conclusions Use of biomass fuels is associated with child size at birth. Future studies should investigate this association using more direct methods for measurement of exposure to smoke emitted from biomass fuels and birth weight.

  10. 员工建言行为的人口统计特征元分析%A meta-analysis of the relationship between demographic characteristics and employee voice behavior

    Institute of Scientific and Technical Information of China (English)

    段锦云; 张晨; 徐悦

    2016-01-01

    The method of meta-analysis was utilized to analyze the relationship between demographic characteristics and voice behavior.Eighty-one primary empirical studies with a total sample size of 39118 participants were included in this study.Results of the meta-analysis showed that age,education,tenure and position were positively and significantly correlated with voice behavior.Namely,older employees with higher level of education and longer tenure would present more voice behavior.Meanwhile,the relationship between position and voice behavior had significantly variance under different cultural background.The test of moderating effect disclosed that culture played an moderator role in the relationship of position and voice behavior.Namely,due to the influence of Chinese traditional culture,employees in China who in low positions dared not to speak up to their supervisors thus their voice quantity was significantly less than those in high positions.However,this variance was not quite obvious in other culture.What's more,the positive relationship between age and voice behavior was moderated by the evaluation method of voice in such a way that it became stronger when the assessment was conducted by others (i.e.Leaders or peers) than by themselves.The study results provided more accurate estimates for predicting voice behavior by demographic characteristics and also the future research directions of voice behavior.%研究目的在于明确人口统计学特征与员工建言行为的关系.共81篇实证文献被纳入元分析,被试人数为39118人.结果发现,员工年龄、教育程度、组织任期和职位均与建言行为显著正相关,即年龄越大、受教育程度越高、组织任期越长的员工会表现出越多建言行为;同时,在不同的文化背景下,职位高低与建言行为的关系存在显著差异,受中国传统文化影响,高、低职位员工的建言行为数量差异明显,而在非中国情境下,员工职位高低对其建言行

  11. Whole genome association analysis shows that ACE is a risk factor for Alzheimer's disease and fails to replicate most candidates from Meta-analysis.

    Science.gov (United States)

    Webster, Jennifer; Reiman, Eric M; Zismann, Victoria L; Joshipura, Keta D; Pearson, John V; Hu-Lince, Diane; Huentelman, Matthew J; Craig, David W; Coon, Keith D; Beach, Thomas; Rohrer, Kristen C; Zhao, Alice S; Leung, Doris; Bryden, Leslie; Marlowe, Lauren; Kaleem, Mona; Mastroeni, Diego; Grover, Andrew; Rogers, Joseph; Heun, Reinhard; Jessen, Frank; Kölsch, Heike; Heward, Christopher B; Ravid, Rivka; Hutton, Michael L; Melquist, Stacey; Petersen, Ron C; Caselli, Richard J; Papassotiropoulos, Andreas; Stephan, Dietrich A; Hardy, John; Myers, Amanda

    2010-01-01

    For late onset Alzheimer's disease (LOAD), the only confirmed, genetic association is with the apolipoprotein E (APOE) locus on chromosome 19. Meta-analysis is often employed to sort the true associations from the false positives. LOAD research has the advantage of a continuously updated meta-analysis of candidate gene association studies in the web-based AlzGene database. The top 30 AlzGene loci on May 1(st), 2007 were investigated in our whole genome association data set consisting of 1411 LOAD cases and neuropathoiogicaiiy verified controls genotyped at 312,316 SNPs using the Affymetrix 500K Mapping Platform. Of the 30 "top AlzGenes", 32 SNPs in 24 genes had odds ratios (OR) whose 95% confidence intervals that did not include 1. Of these 32 SNPs, six were part of the Affymetrix 500K Mapping panel and another ten had proxies on the Affymetrix array that had >80% power to detect an association with α=0.001. Two of these 16 SNPs showed significant association with LOAD in our sample series. One was rs4420638 at the APOE locus (uncorrected p-value=4.58E-37) and the other was rs4293, located in the angiotensin converting enzyme (ACE) locus (uncorrected p-value=0.014). Since this result was nominally significant, but did not survive multiple testing correction for 16 independent tests, this association at rs4293 was verified in a geographically distinct German cohort (p-value=0.03). We present the results of our ACE replication aiongwith a discussion of the statistical limitations of multiple test corrections in whole genome studies.

  12. [Demands on the legal pension security system based on the demographic change].

    Science.gov (United States)

    Rürup, B

    1996-01-01

    This paper deals with the German public pension system which is affected by changing demographics. It examines whether the problems can be solved more efficiently by either a fundamental change towards a tax-financed basic allowance augmented by a private capital accumulation sheme, or by adjustments within the present system of wage-determined contributions. The analysis shows that basic allowance and capital accumulation systems are inadequate, essentially for macroeconomic reasons and adverse effects on redistribution, to the demographically induced problems of the public pension system.

  13. Birth tourism: socio-demographic and statistical aspects

    Directory of Open Access Journals (Sweden)

    Anatoly V. Korotkov

    2016-01-01

    Full Text Available The purpose of the study is to research birth tourism issue. The article gives the socio-demographic and statistical aspects of research problems of birth inbound tourism in the Russian Federation. Following the literature analysis, the degree of study for birth tourism lags behind its actual size. Currently, the media has accumulated a significant amount of information on birth tourism in Russia, that requires processing, systematization and understanding that can and should become an independent area of study of sociologists and demographers to develop recommendations for the management of socio-demographic processes in birth tourism in our country. It is necessary to identify the problems that will inevitably arise. At present, this process is almost not regulated.These problems are complex, it requires the joint efforts of sociologists and demographers. However, it is impossible to obtain reliable results and to develop management decisions without attention to the statistical aspect of this problem. It is necessary to create methodological support for collecting and information processing and model development of the birth tourism. At the initial stage it is necessary to identify the direction and objectives of the analysis to determine the factors in the development of this process, to develop a hierarchical system of statistical indicators, to receive the information, needed for calculating of specific indicators.The complex research of the birth tourism issues should be based on the methodology of sociology, demography and statistics, including statistical observation, interviews with residents, structure analysis and birth tourism concentration in the country, the analysis of the dynamics, classification of factors and reasons, the grouping of regions for the development of the studied processes and, of course, the development of economic-statistical indicators.The article reveals the problem of the significant influence of the

  14. Managing demographic risk.

    Science.gov (United States)

    Strack, Rainer; Baier, Jens; Fahlander, Anders

    2008-02-01

    In developed nations, the workforce is aging rapidly. That trend has serious implications. Companies could face severe labor shortages in a few years as workers retire, taking critical knowledge with them. Businesses may also see productivity decline among older employees, especially in physically demanding jobs. The authors, partners at Boston Consulting Group, offer managers a systematic way to assess these dual threats--capacity risk and productivity risk--at their companies. It involves studying the age distribution of their employees to see if large percentages fall within high age brackets and then projecting--by location, unit, and job category--how the distribution will change over the next 15 years. Managers must also factor in both the impact of strategic moves on personnel needs and the future supply of workers in the market. When RWE Power analyzed its trends, the company learned that in 2018 almost 80% of its workers would be over 50. What's more, in certain critical areas its labor surplus was about to become a sizable shortfall. For instance, a shortage of specialized engineers would develop in the company just as their ranks in the job market thinned and competition to hire them intensified. Reversing its downsizing course, RWE Power took steps to increase its supply of workers in those key positions. The authors show how companies that face talent gaps, as RWE Power did, can close them through training, transfers, recruitment, retention, productivity improvements, and outsourcing. They also describe measures that companies can take to keep older workers productive, including workplace accommodations, revised compensation structures, performance incentives, and targeted health care management. The key is to identify and address potential problems early. Firms that do so will gain an edge on rivals that are still relentlessly focused on reducing head count.

  15. Empathy, Burnout, Demographic Variables and their Relationships in Oncology Nurses.

    Science.gov (United States)

    Taleghani, Fariba; Ashouri, Elaheh; Saburi, Morteza

    2017-01-01

    Development of nurse-patient empathic communication in the oncology ward is of great importance for the patients to relieve their psychological stress, however, nursing care of cancer patients is accompanied with high stress and burnout. The present study aimed to define the level of empathy and its association with burnout and some demographic characteristics of oncology nurses. This descriptive/correlation study was conducted in a professional cancer treatment center in Isfahan. Through census sampling, 67 oncology nurses were selected. The data collection tools were Jefferson Scale of Nursing Empathy, Maslach Burnout Inventory, and demographic characteristics questionnaire. Mean nurses' empathy and overall burnout scores were 62.28 out of 100 and 38.8 out of 100, respectively. Score of empathy showed an inverse correlation with overall burnout score (r = -0.189, P = 0.04), depersonalization (r = -0.218, P = 0.02), and personal accomplishment (r = -0.265, P = 0.01). Multiple regression test was used to detect which dimension of burnout was a better predictor for the reduction of empathy score. Results showed that the best predictors were lack of personal accomplishment (P = 0.02), depersonalization (P = 0.04), and emotional exhaustion (P = 0.14), respectively. The most influential demographic factor on empathy was work experience (r = 0.304, P = 0.004). One-way analysis of variance showed that official staff had a higher empathy score (f = 2.39, P = 0.045) and their burnout was lower (f = 2.56, P = 0.04). Results showed a negative relationship between empathy and burnout in oncology nurses. Therefore, nursing support from managers to reduce burnout increases empathic behavior of nurses.

  16. Analysis of the individual factors affecting mobile phone use while driving in France: socio-demographic characteristics, car and phone use in professional and private contexts.

    Science.gov (United States)

    Brusque, Corinne; Alauzet, Aline

    2008-01-01

    In France, as in many other countries, phoning while driving is legally restricted because of its negative impact on driving performance which increases accident risk. Nevertheless, it is still a frequently observed practice and one which has not been analyzed in detail. This study attempts to identify the profiles of those who use mobile phones while at the wheel and determine the forms taken by this use. A representative sample of 1973 French people was interviewed by phone on their driving practices and mobile phone use in everyday life and their mobile phone use while driving. Logistics regressions have been conducted to highlight the explanatory factors of phoning while driving. Strong differences between males and females have been shown. For the male population, age is the main explanatory factor of phoning while driving, followed by phone use for work-related reasons and extensive mobile phone use in everyday life. For females, high mileage and intensive use of mobile phone are the only two explanatory factors. We defined the intensive phone use at the wheel group as drivers who receive or send at least five or more calls per day while driving. There is no socio-demographic variable related to this practice. Car and phone uses in everyday life are the only explanatory factors for this intensive mobile use of the phone at the wheel.

  17. Urbanisation and geographic variation of overweight and obesity in India: a cross-sectional analysis of the Indian Demographic Health Survey 2005-2006.

    Science.gov (United States)

    Siddiqui, Saad T; Kandala, Ngianga-Bakwin; Stranges, Saverio

    2015-09-01

    We examined the nationwide geographic variation of overweight and obesity in India, as well as a range of potential correlates of excess body fat. We conducted cross-sectional analyses of the 2005-2006 Indian Demographic Health Survey (IDHS), based on 161,050 individuals (age range 18-54 years). Multivariate logistic regression models were used to determine odds ratios (OR) of overweight and obesity compared to normal weight with associated correlates. The overall prevalence was 12.4% for overweight, 3.2% for obesity, and 26.5% for underweight. After multivariate adjustment, obesity was nearly thrice more likely in urban areas than in rural (OR 2.73, 95% CI 2.53-2.94). Women were 2.71 times more likely to be obese than men (95% CI 2.50-2.95). Better socioeconomic status was significantly associated with overweight and obesity. Overweight (OR 1.38, 95% CI 1.31-1.47) and obesity (OR 1.46, 95% CI 1.32-1.61) were most likely to occur in India's Southern zone, when controlled for confounding factors. High-risk estimates for overweight/obesity in urban settings, along with socioeconomic prowess in India and the resulting nutritional transition make a compelling case for public health policy on healthy lifestyles to avert the growing burden of non-communicable diseases associated with overweight/obesity.

  18. Attitudes Toward Intimate Partner Violence and Associations With Condom Use Among Men in Haiti: An Analysis of the Nationally Representative Demographic Health Survey.

    Science.gov (United States)

    Conserve, Donaldson F; Whembolua, Guy-Lucien S; Surkan, Pamela J

    2016-03-01

    Although men have substantial decision-making power regarding condom use, the majority of HIV knowledge and prevention studies in the general Haitian population have been conducted among youth and women. We investigated attitudes toward intimate partner violence, knowledge of, and use of condoms among 9493 men in Haiti using data from the 2012 nationally representative Demographic and Health Survey. Only 36% of HIV-negative and 44% of HIV-positive men reported using a condom the last time they had had sex. Logistic regression revealed that believing it was justified for a man to hit or beat his wife if she refuses to have sex with him was associated with a lower odds of condom use. The odds of using a condom during last sex was higher among men who reported knowing condoms can prevent HIV and who had been tested for HIV. Given the low rate of condom use among men in Haiti, these findings suggest that interventions promoting HIV knowledge, HIV testing, and gender-violence prevention among men may also increase condom use.

  19. Knowledge in schizophrenia: The Portuguese version of KAST (Knowledge About Schizophrenia Test) and analysis of social-demographic and clinical factors' influence.

    Science.gov (United States)

    Daltio, C S; Attux, C; Ferraz, M B

    2015-10-01

    Schizophrenia is a complex disorder, and the knowledge about it can have a positive impact. The purpose of this study was to make the translation and cultural adaptation of the Knowledge About Schizophrenia Test (KAST) into Portuguese and determine the influence of clinical and socio-demographic factors on knowledge. The test was applied to 189 caregivers of patients enrolled in Schizophrenia Program of the Federal University of São Paulo, 30 caregivers of clinical patients of the General Outpatient Clinic of the same University, and 30 health professionals. The face and content validity of the test was established. The mean value (SD) obtained with the application of the final version to caregivers of schizophrenic patients was 12.96 (2.45) - maximum 17. Level of knowledge increased considering the following order: caregivers of clinical patients, caregivers of patients with schizophrenia and mental health professionals. The intraclass correlation coefficient (0.592) obtained in the test-retest was statistically significant. An influence of social class, race, gender and education of the caregiver on the test was observed, and the last two factors were more relevant. The KAST translated and adapted into Portuguese is a valid instrument and can be used as an evaluation tool on psychoeducational interventions. Copyright © 2015 Elsevier B.V. All rights reserved.

  20. Initial medical management of rotator cuff tears: a demographic analysis of surgical and nonsurgical treatment in the United States Medicare population.

    Science.gov (United States)

    Varkey, Dax T; Patterson, Brendan M; Creighton, R Alexander; Spang, Jeffrey T; Kamath, Ganesh V

    2016-12-01

    Rotator cuff tears have a lifetime incidence between 25% and 40% in the United States, but optimum treatment strategies and protocol have not yet been widely accepted. This study evaluated the proportions of patients treated with nonoperative and operative modalities and how this proportion has changed during an 8-year period (2005-2012) among patients with Medicare. Using the PearlDiver patient record database, we identified Medicare patients having been diagnosed with a rotator cuff tear. These patients were then stratified on the basis of treatment with physical therapy, subacromial/glenohumeral injection, or rotator cuff repair. We analyzed the data in regard to standard demographic information, comorbidities, and the Charlson Comorbidity Index. During the study period, 878,049 patients were identified and 397,116 patients had rotator cuff repair. The proportion of patients treated initially with physical therapy dropped from 30.0% in 2005 to 13.2% in 2012, and the subacromial/glenohumeral injection proportion decreased from 6.00% to 4.19% (P rotator cuff repair increased from 33.8% to 40.4% from 2005 to 2012 (P rotator cuff repair had fewer comorbidities than those undergoing nonoperative treatments. It also demonstrates that patients who had a trial of injection had a higher incidence of eventual rotator cuff repair compared with the patients with an initial trial of physical therapy. Copyright © 2016 Journal of Shoulder and Elbow Surgery Board of Trustees. Published by Elsevier Inc. All rights reserved.

  1. Demographic Pressure in the European Union

    OpenAIRE

    Peeters, Marga; Groot, Loek

    2012-01-01

    On top of the sovereign debt crisis in the European Union, demographic change is exerting enormous pressure on public finances. We analyse four policy options: lowering pension benefits, increasing labour market participation of the native population, immigration and participation of older people. Our results show that the most publically indebted EU economies face the highest increases in public spending on the retiring baby boom generations over the coming decades. Fortunately for these eco...

  2. Intelligent system to study demographic evolution

    Science.gov (United States)

    Rodrigues, M. de Fatima; Ramos, Carlos; Henriques, Pedro R.

    1999-02-01

    With three centuries of existence, the study of population's behavior implies the manipulation of large amounts of incomplete and imprecise data with high dimensionality. By virtue of its multidisciplinary character, the work in demography involves at least historicists, statisticians and computer scientists/programmers. Moreover, successful demographic analysis requires qualified experts, who have succeeded in analysing data through many views and relate different sources of information, including their personal knowledge of the epoch or regions under study. In this paper, we present an intelligent system to study demographic evolution (ISSDE). This system has a module based on on-line analytical processing (OLAP), which permits conducting multiple analysis, combining many data dimensions. It has a deductive database system, which allows the execution of elaborated queries through the database. It has another module for date treatment (generalization and/or reduction); and, at last, a data mining module to discover nontrivial relations hidden within data. We discover the data treatment procedure with two phases: data generalization and data reduction. In data generalization, utilizing knowledge about concept hierarchies and relevance of data, aggregation of attribute values is performed. In the data reduction phase, rough set theory is applied to compute the minimal attribute set. We highlight the advantages of combining attribute value generalization with rough set theory, to find a subset of attributes that lets the mining process discover more useful patterns, by providing results from the application of the C5.0 algorithm in a demographic relational database.

  3. Tourism Market and Demographic Changes

    Directory of Open Access Journals (Sweden)

    Alexandru Nedelea

    2008-10-01

    Full Text Available This paper identifies the major demographic trends and their implications for consumer market. It is important to know how will demographic change influence the tourism market in particularly and how can the tourist industry adapt to these. The advancing ageing of society will result in far reaching changes, particularly on the demand side. To profitably seize the opportunities, managers must understand how senior markets evolve and adapt products and service offerings along multiple dimensions to meet the needs of senior consumers.

  4. Associations between dietary patterns, socio-demographic factors and anthropometric measurements in adult New Zealanders: an analysis of data from the 2008/09 New Zealand Adult Nutrition Survey.

    Science.gov (United States)

    Beck, K L; Jones, B; Ullah, I; McNaughton, S A; Haslett, S J; Stonehouse, W

    2017-04-04

    To investigate associations between dietary patterns, socio-demographic factors and anthropometric measurements in adult New Zealanders. Dietary patterns were identified using factor analysis in adults 15 years plus (n = 4657) using 24-h diet recall data from the 2008/09 New Zealand Adult Nutrition Survey. Multivariate regression was used to investigate associations between dietary patterns and age, gender and ethnicity. After controlling for demographic factors, associations between dietary patterns and food insecurity, deprivation, education, and smoking were investigated. Associations between dietary patterns and body mass index and waist circumference were examined adjusting for demographic factors, smoking and energy intake. Two dietary patterns were identified. 'Healthy' was characterised by breakfast cereal, low fat milk, soy and rice milk, soup and stock, yoghurt, bananas, apples, other fruit and tea, and low intakes of pies and pastries, potato chips, white bread, takeaway foods, soft drinks, beer and wine. 'Traditional' was characterised by beef, starchy vegetables, green vegetables, carrots, tomatoes, savoury sauces, regular milk, cream, sugar, tea and coffee, and was low in takeaway foods. The 'healthy' pattern was positively associated with age, female gender, New Zealand European or other ethnicity, and a secondary school qualification, and inversely associated with smoking, food insecurity, area deprivation, BMI and waist circumference. The 'traditional' pattern was positively associated with age, male gender, smoking, food insecurity and inversely associated with a secondary school qualification. A 'Healthy' dietary pattern was associated with higher socio-economic status and reduced adiposity, while the 'traditional' pattern was associated with lower socio-economic status.

  5. Socio-demographic inequalities in the prevalence, diagnosis and management of hypertension in India: analysis of nationally-representative survey data.

    Science.gov (United States)

    Moser, Kath A; Agrawal, Sutapa; Davey Smith, George; Ebrahim, Shah

    2014-01-01

    Hypertension is a major contributing factor to the current epidemic of cardiovascular disease in India. Small studies suggest high, and increasing, prevalence especially in urban areas, with poor detection and management, but national data has been lacking. The aim of the current study was to use nationally-representative survey data to examine socio-demographic inequalities in the prevalence, diagnosis and management of hypertension in Indian adults. Using data on self-reported diagnosis and treatment, and blood pressure measurement, collected from 12,198 respondents aged 18+ in the 2007 WHO Study on Global Ageing and Adult Health in India, factors associated with prevalence, diagnosis and treatment of hypertension were investigated. 22% men and 26% women had hypertension; prevalence increased steeply with body mass index (<18.5 kg/m(2): 18% men, 21% women; 25-29.9 kg/m(2): 35% men, 35% women), was higher in the least poor vs. poorest (men: odds ratio (95%CI) 1.82 (1.20 to 2.76); women: 1.40 (1.08 to 1.81)), urban vs. rural men (1.64 (1.19 to 2.25)), and men recently vs. never using alcohol (1.96 (1.40 to 2.76)). Over half the hypertension in women, and 70% in men, was undetected with particularly poor detection rates in young urban men, and in poorer households. Two-thirds of men and women with detected hypertension were treated. Two-thirds of women treated had their hypertension controlled, irrespective of urban/rural setting or wealth. Adequate blood pressure control was sub-optimal in urban men. Hypertension is very common in India, even among underweight adults and those of lower socioeconomic position. Improved detection is needed to reduce the burden of disease attributable to hypertension. Levels of treatment and control are relatively good, particularly in women, although urban men require more careful attention.

  6. Determinants of fertility in Rwanda in the context of a fertility transition: a secondary analysis of the 2010 Demographic and Health Survey.

    Science.gov (United States)

    Ndahindwa, Vedaste; Kamanzi, Collins; Semakula, Muhammed; Abalikumwe, François; Hedt-Gauthier, Bethany; Thomson, Dana R

    2014-12-13

    Major improvements to Rwanda's health system, infrastructure, and social programs over the last decade have led to a rapid fertility transition unique from other African countries. The total fertility rate fell from 6.1 in 2005 to 4.6 in 2010, with a 3-fold increase in contraceptive usage. Despite this rapid national decline, many women still have large numbers of children. This study investigates predictors of fertility during this fertility transition to inform policies that improve individuals' reproductive health and guide national development. We used Poisson regression to separately model number of children born to ever married/cohabitated women (n = 8,309) and never married women (n = 1,220) age 15 to 49 based on 2010 Rwanda Demographic and Health Survey data. We used backward stepwise regression with a time offset to identify individual and household factors associated with woman's fertility level, accounting for sampling weights, clustering, and stratification. In ever married/cohabitating women, high fertility was significantly associated (p fertility in ever married/cohabitating women was associated with women's education (higher versus no education: IRR = 0.66), household wealth (highest versus lowest quintile: IRR = 0.93), and delayed sexual debut (25+ versus 8-18 years: IRR = 0.49). In never married women, low fertility was associated with education (higher versus no education: IRR = 0.22), household wealth (highest versus lowest quintile: IRR = 0.58), delayed sexual debut (25-49 versus 8-18 years: IRR = 0.43), and having an unmet need for contraception (IRR = 0.69). Although the study design does not allow causal conclusions, these results suggest several strategies to further reduce Rwanda's national fertility rate and support families to achieve their desired fertility. Strategies include policies and programs that promote delayed sexual debut via educational and economic opportunities for women, improved access to reproductive health information

  7. Prevalence and pattern of HIV-related malnutrition among women in sub-Saharan Africa: a meta-analysis of demographic health surveys

    Directory of Open Access Journals (Sweden)

    Uthman Olalekan A

    2008-07-01

    Full Text Available Abstract Background The world's highest HIV infection rates are found in Sub-Saharan Africa (SSA, where adult prevalence in most countries exceeds 25%. Food shortages and malnutrition have combined with HIV/AIDS to bring some countries to the brink of crisis. The aim of this study was to describe prevalence of malnutrition among HIV-infected women and variations across socioeconomic status using data from 11 countries in SSA. Methods This study uses meta-analytic procedures to synthesize the results of most recent data sets available from Demographic and Health Surveys of 11 countries in SSA. Pooled prevalence estimates and 95% confidence intervals were calculated using random-and fixed-effects models. Subgroup and leave-one-country-out sensitivity analyses were also carried out. Results Pooling the prevalence estimates of HIV-related malnutrition yielded an overall prevalence of 10.3% (95% CI 7.4% to 14.1% with no statistically significant heterogeneity (I2 = 0.0%, p = .903. The prevalence estimates decreased with increasing wealth index and education attainment. The pooled prevalence of HIV-related malnutrition was higher among women residing in rural areas than among women residing in urban areas; and lower among women that were professionally employed than unemployed or women in agricultural or manual work. Conclusion Prevalence of HIV-related malnutrition among women varies by wealth status, education attainment, occupation, and type of residence (rural/urban. The observed socioeconomic disparities can help provide more information about population subgroups in particular need and high risk groups, which may in turn lead to the development and implementation of more effective intervention programs.

  8. Early father–daughter relationship and demographic determinants of spousal marital satisfaction

    Directory of Open Access Journals (Sweden)

    Alsheikh Ali A

    2016-04-01

    Full Text Available Ahmad Alsheikh Ali,1 Fawzi Shaker Daoud2 1Counseling Psychology Program, Faculty of Educational Sciences, Hashemite University, 2Department of Psychology, Faculty of Arts and Sciences, Al-Ahliyya Amman University, Amman, Jordan Abstract: This study examined several dimensions of early father–daughter relationship as predictors of marital satisfaction among 494 respondents. Descriptive comparative approach was used in result analysis. The Father Presence Questionnaire and Marital Satisfaction Questionnaire were used, in addition to a number of demographic variables. Results showed that only physical relationship with the father, and perceptions of father’s influence, had a positive significant impact on wives’ marital satisfaction. Of all domains, only positive feelings about the father had a negative impact on the husband's marital satisfaction. Most demographic variables had statistically significant effect on marital satisfaction. Sociocultural implications for marital satisfaction for wives and husbands are discussed. Keywords: early father–daughter relationship, demographic, spousal marital satisfaction

  9. [Health expenditure in the context of social expenditure. A generational analysis of tendencies in Spain in the context of demographic aging. 2008 SESPAS Report].

    Science.gov (United States)

    López Casasnovas, Guillem; Mosterín Höpping, Ana

    2008-04-01

    The tendency for public welfare spending to be increasingly aimed at the elderly has been identified in several developed countries. While population aging is a common trend, it is not obvious why the shift in spending exceeds the trend in aging, or why per capita spending on the elderly is increasing. In the first part of the present article, we show that this trend is occurring in Spain, identify the losers from this development, discuss the policies that underlie it, and propose adjustments based on Musgrave's fixed proportions rule for fair intergenerational distribution. These policies aim to manage population aging, labor market participation of youth and women, as well as public policies that combine 'work-fare' strategies with the more traditional 'welfare' strategies. In the second part of this paper, we explore the contribution of public health expenditure to overall public social expenditure, and analyze the effect of increasing health on distributional fairness. This analysis is guided by our perception that social policy, including health policy, should be more horizontal, i.e. it should take into account the sum total of a mixed basket of resources aimed at any recipient group, to avoid the skewed allocation of resources that arises from compounding various independent distributions of resources. Coordination of the various channels of social expenditure should ensure precisely targeted recipients and cross-departmental sources. The normative fairness criterion to be used should be precisely specified. In Spain (1980-2000) the oldest segment of the population has gained the most, appropriating an increased share of resources. This increase goes beyond the amount that could be explained by population aging throughout the period. The 'losers' are individuals with different fragility conditions. On average the youngest working group has suffered the highest relative loss.

  10. 人口结构转变及其对宏观经济运行影响评述%Demographic Transition and Its Effects on Macro Economy: A Literature Analysis

    Institute of Scientific and Technical Information of China (English)

    张馨艺; 张琼

    2012-01-01

    人口结构转变如何影响宏观经济运行既是一个国际性的命题也是一个颇具中国特色的典型问题,国内外学者已就此展开了长时间的多角度探索,但鲜有研究对此进行系统性总结.本文以人口结构转变理论演进为切入点,结合现有分析方法和结论对人口结构转变影响宏观经济运行的传导路径进行了回顾性梳理.结论表明,首先就方法论而言,人口对宏观经济影响的文献已经从早期的总量分析过渡到了如今的结构性分析,并且学者在分析过程中也逐渐从人口如何影响一国或地区的消费、储蓄、投资、进出口贸易以及国际资本流动等中间变量的角度来思考人口对宏观经济影响的具体传导路径;其次,尽管文献结论倾向于认为人口结构转变会对这些中间变量产生影响,但影响的方向与幅度远未达成一致,从而意味着人口结构转变对宏观经济运行的最终影响并无定论;这既与理论分析未成定论相对应,也与学者所采用的数据和方法不同等密切相关.因此,本文认为尽管分析人口对宏观经济影响的研究颇多,但在中国特色国情背景下相关方面的研究仍任重道远.%How demographic transition affects macro economy has always been not only an international proposition, but also a typical topic with Chinese characteristics. Therefore both domestic and foreign scholars have considered the relationship between population and economic development from various aspects for a long time, while few studies have reached an agreement on conclusions so far. This paper starts with a review on theoretical evolution of related literature, and then retrospectively summarizes possible mechanisms of demographic transition on macro economy. It finds that, firstly, in terms of methodology, related researches have changed their focus on aggregate analysis at the very early first stage to recent structural investigations, and further

  11. Complexity and demographic explanations of cumulative culture.

    Directory of Open Access Journals (Sweden)

    Adrien Querbes

    Full Text Available Formal models have linked prehistoric and historical instances of technological change (e.g., the Upper Paleolithic transition, cultural loss in Holocene Tasmania, scientific progress since the late nineteenth century to demographic change. According to these models, cumulation of technological complexity is inhibited by decreasing--while favoured by increasing--population levels. Here we show that these findings are contingent on how complexity is defined: demography plays a much more limited role in sustaining cumulative culture in case formal models deploy Herbert Simon's definition of complexity rather than the particular definitions of complexity hitherto assumed. Given that currently available empirical evidence doesn't afford discriminating proper from improper definitions of complexity, our robustness analyses put into question the force of recent demographic explanations of particular episodes of cultural change.

  12. The AAVSO 2011 Demographic and Background Survey

    CERN Document Server

    Price, C Aaron

    2012-01-01

    In 2011, the AAVSO conducted a survey of 615 people who are or were recently active in the 101-year old organization. The survey included questions about their demographic background and variable star interests. Data are descriptively analyzed and compared with prior surveys. Results show an organization of very highly educated, largely male amateur and professional astronomers distributed across 108 countries. Participants tend to be loyal, with the average time of involvement in the AAVSO reported as 14 years. Most major demographic factors have not changed much over time. However, the average age of new members is increasing. Also, a significant portion of the respondents report being strictly active in a non-observing capacity, reflecting the growing mission of the organization. Motivations of participants are more aligned with scientific contribution than with that reported by other citizen science projects. This may help explain why a third of all respondents are an author or co-author of a paper in an ...

  13. Demographic Modelling in Weed Biocontrol

    Science.gov (United States)

    Demographic matrix modeling of plant populations can be a powerful tool to identify key life stage transitions that contribute the most to population growth of an invasive plant and hence should be targeted for disruption. Therefore, this approach has the potential to guide the pre-release selection...

  14. Logistics Dynamics and Demographic Change

    NARCIS (Netherlands)

    Klumpp, Matthias; Abidi, Hella; Bioly, Sascha; Buchkremer, Rüdiger; Sandhaus, Gregor; Freitag, Michael; Kotzab, Herbert; Pannek, Jürgen

    2016-01-01

    Change and dynamics in logistics are interestingly driven at the same time by external as well as internal forces. This contribution outlines a big data literature review methodology to overview recognizable external changes and analyzes the interaction of one major trend—demographic change—further

  15. Socio-demographic inequalities in the prevalence, diagnosis and management of hypertension in India: analysis of nationally-representative survey data.

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    Kath A Moser

    Full Text Available BACKGROUND: Hypertension is a major contributing factor to the current epidemic of cardiovascular disease in India. Small studies suggest high, and increasing, prevalence especially in urban areas, with poor detection and management, but national data has been lacking. The aim of the current study was to use nationally-representative survey data to examine socio-demographic inequalities in the prevalence, diagnosis and management of hypertension in Indian adults. METHODS: Using data on self-reported diagnosis and treatment, and blood pressure measurement, collected from 12,198 respondents aged 18+ in the 2007 WHO Study on Global Ageing and Adult Health in India, factors associated with prevalence, diagnosis and treatment of hypertension were investigated. RESULTS: 22% men and 26% women had hypertension; prevalence increased steeply with body mass index (<18.5 kg/m(2: 18% men, 21% women; 25-29.9 kg/m(2: 35% men, 35% women, was higher in the least poor vs. poorest (men: odds ratio (95%CI 1.82 (1.20 to 2.76; women: 1.40 (1.08 to 1.81, urban vs. rural men (1.64 (1.19 to 2.25, and men recently vs. never using alcohol (1.96 (1.40 to 2.76. Over half the hypertension in women, and 70% in men, was undetected with particularly poor detection rates in young urban men, and in poorer households. Two-thirds of men and women with detected hypertension were treated. Two-thirds of women treated had their hypertension controlled, irrespective of urban/rural setting or wealth. Adequate blood pressure control was sub-optimal in urban men. CONCLUSION: Hypertension is very common in India, even among underweight adults and those of lower socioeconomic position. Improved detection is needed to reduce the burden of disease attributable to hypertension. Levels of treatment and control are relatively good, particularly in women, although urban men require more careful attention.

  16. Time trends and inequalities of under-five mortality in Nepal: a secondary data analysis of four demographic and health surveys between 1996 and 2011.

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    Chandrashekhar T Sreeramareddy

    Full Text Available BACKGROUND: Inequalities in progress towards achievement of Millennium Development Goal four (MDG-4 reflect unequal access to child health services. OBJECTIVE: To examine the time trends, socio-economic and regional inequalities of under-five mortality rate (U5MR in Nepal. METHODS: We analyzed the data from complete birth histories of four Nepal Demographic and Health Surveys (NDHS done in the years 1996, 2001, 2006 and 2011. For each livebirth, we computed survival period from birth until either fifth birthday or the survey date. Using direct methods i.e. by constructing life tables, we calculated yearly U5MRs from 1991 to 2010. Projections were made for the years 2011 to 2015. For each NDHS, U5MRs were calculated according to child's sex, mother's education, household wealth index, rural/urban residence, development regions and ecological zones. Inequalities were calculated as rate difference, rate ratio, population attributable risk and hazard ratio. RESULTS: Yearly U5MR (per 1000 live births had decreased from 157.3 (95% CIs 178.0-138.9 in 1991 to 43.2 (95% CIs 59.1-31.5 in 2010 i.e. 114.1 reduction in absolute risk. Projected U5MR for the year 2015 was 54.33. U5MRs had decreased in absolute terms in all sub groups but relative inequalities had reduced for gender and rural/urban residence only. Wide inequalities existed by wealth and education and increased between 1996 and 2011. For lowest wealth quintile (as compared to highest quintile hazard ratio (HR increased from 1.37 (95% CIs 1.27, 1.49 to 2.54 ( 95% CIs 2.25, 2.86 and for mothers having no education (as compared to higher education HR increased from 2.55 (95% CIs 1.95, 3.33 to 3.75 (95% CIs 3.17, 4.44. Changes in regional inequities were marginal and irregular. CONCLUSIONS: Nepal is most likely to achieve MDG-4 but eductional and wealth inequalities may widen further. National health policies should address to reduce inequalities in U5MR through 'inclusive policies'.

  17. A multilevel analysis of effect of neighbourhood and individual wealth status on sexual behaviour among women: evidence from Nigeria 2003 Demographic and Health Survey

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    Kongnyuy Eugene J

    2008-06-01

    Full Text Available Abstract Background Nigeria is home to more people living with HIV than any other country in the world, except South Africa and India – where an estimated 2.9 million [1.7 million – 4.2 million] people were living with the virus in 2005. Women bear the greatest burden of frequent high-risk pregnancies, raising large families, and increasingly, the AIDS epidemic. Thus, there is a need for better understanding of the determinants of high risk sexual behaviour among women. In this study, we examined factors associated with extra-marital sex among women in Nigeria and investigated how much variation in reported extra-marital sex can be attributed to individual-, and community-level factors. Methods We analyzed data from 6362 sexually active women aged 15 – 49 years who participated in the Nigeria 2003 Demographic and Health Survey using multilevel logistic regression models. Results are presented as odds ratio with 95% confidence interval. Results Independent of other factors, compared to women aged 15–24 years, those 25 – 34 years (odds ratio [OR] 0.59; 95% CI: 0.44 – 0.79 and 35 years or older (OR 0.36; 95% CI: 0.24 – 0.54 were less likely to have reported multiple concurrent sex partners in the last 12 years. As expected, women currently or formerly married were less likely to have reported multiple concurrent sex partners than women never married. Women who drank alcohol in the last three months were more likely to have reported multiple concurrent sex partners. Compared to women from richest household, women from poorest and middle household were 83% and 51% more likely to multiple concurrent sex partners in the last 12 month respectively. After individual compositional and contextual factors, community wealth status was statistically significant with sexual behaviour. Conclusion The study has demonstrated that individual and community wealth status are independent predictors of women's sexual behaviour, and that there is

  18. Demographic Risks of the Pension Reform in the Russian Federation

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    Arkady Konstantinovich Solovyev

    2016-03-01

    Full Text Available The purpose of the study is to analyze the impact of the demographic crisis in the country’s fiscal system. In the article, the pension system for the first time is considered as a multifactorial model, which during the different historical periods corrects the degree of its dependence on the interdependent complex of macroeconomic and demographic factors. The economically sound and socially correct accounting of the interference of retirement age and the specified development factors of pension system requires a fundamental change in the methodological approaches to the problem of raising the retirement age by using the actuarial methods of forecasting. The actuarial analysis of the problem of retirement age shows that the perception of the linear dependence on demographic parameters of the age when the national pension is awarded cannot be considered as a tool for regulating the efficiency of the pension system. For the science-based solution to the problem of rising the retirement age, along with the dynamics of demographic parameters, it is necessary to take into account the whole range of macroeconomic conditions for the state development as well as the long-term socio-economic consequences. Another significant result of the study are the specific parameters of the actuarial assessments of the impact of demographic and macroeconomic conditions of increasing the retirement age in Russia, conducted using the state statistical data. The practical proposals to mitigate the negative economic consequences are formulated. The key conclusion reached is that the raising of the retirement age should be aimed exclusively at the economic stimulation of the formation of the pension rights of the insured in the long term, rather than to the short-term savings of the state budget. The methodological approaches grounded in the work, and the quantitative results of the actuarial calculations may be applied in the shaping the public pension policy when

  19. Demographic Estimation from Face Images: Human vs. Machine Performance.

    Science.gov (United States)

    Han, Hu; Otto, Charles; Liu, Xiaoming; Jain, Anil K

    2015-06-01

    Demographic estimation entails automatic estimation of age, gender and race of a person from his face image, which has many potential applications ranging from forensics to social media. Automatic demographic estimation, particularly age estimation, remains a challenging problem because persons belonging to the same demographic group can be vastly different in their facial appearances due to intrinsic and extrinsic factors. In this paper, we present a generic framework for automatic demographic (age, gender and race) estimation. Given a face image, we first extract demographic informative features via a boosting algorithm, and then employ a hierarchical approach consisting of between-group classification, and within-group regression. Quality assessment is also developed to identify low-quality face images that are difficult to obtain reliable demographic estimates. Experimental results on a diverse set of face image databases, FG-NET (1K images), FERET (3K images), MORPH II (75K images), PCSO (100K images), and a subset of LFW (4K images), show that the proposed approach has superior performance compared to the state of the art. Finally, we use crowdsourcing to study the human perception ability of estimating demographics from face images. A side-by-side comparison of the demographic estimates from crowdsourced data and the proposed algorithm provides a number of insights into this challenging problem.

  20. Socio-Demographic Factors Influencing Work-Role Salience Among ...

    African Journals Online (AJOL)

    Socio-Demographic Factors Influencing Work-Role Salience Among ... The findings showed that students from lower socio-economic status homes and those ... The need to involve the students\\' parents in career education programmes and ...

  1. Demographic growth and development of spa places in Serbia

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    Đurđev Branislav S.

    2007-01-01

    Full Text Available The paper deals with analysis of population growth and components of demographic growth in five most important spa settlements in Serbia: Vrnjacka banja, Niska banj, Banja Koviljaca. As indices of demographic development, we have analyzed: natural and mechanical movement of population, age and sex, activity and sex, households and apartments in spa places. The finding is that demographic development of spa places in Serbia has been politically influenced. Due to dismantling state territory of former Yugoslavia, the choice of domestic tourist destination for Serbian population became smaller. Because of that, spas became more important tourist destination which fostered demographic growth of those places. The data analysis demonstrated that during the last six decades, population in all spa places increased with higher insensitive compare with the rest of Serbia. This is the result of high inmigration, particularly in the last decade, when the share of this movement was over 90%. The pacing of population ageing in spa places, did not follow ageing of total population in Serbia. Average age in Serbia between 1961-2002. increased for 31.8%, while in spas population ageing was more intensify with 36.4% increase. The number of household showed constant increase from census to census, as well as in Serbia as in each of spa places with no exception. Average size of household in spas in 1948. was smaller than the average in Serbia for almost one member. By the year 2002. the average sizes of households in spas and in Serbia was almost equalized. Spa places suffered sortage of apartments in 1948. By the year 2002. the evidence showed considerable surplus which as the biggest in Vrnjacka Banja spa. The amount of surplus was 15%, which is higher than the average in Serbia. The purpose of this surplus is rent and accommodation of spa visitors. Overall results point out that despite of population decrease of Serbia, spa places enjoy more and more permanent

  2. DEMOGRAPHIC PREDICTORS WITHIN LOCAL PUBLIC ADMINISTRATION

    Directory of Open Access Journals (Sweden)

    Bente Florina Maria

    2014-12-01

    Design/methodology/approach- Using a quantitative methodological approach, a survey based on SERVQUAL instrument was applied in order to evaluate local public communication. Data from a sample of 380 citizens within Western Romanian were analyzed. Specific demographic predictors that can influence citizens' satisfaction regarding the quality of communication are analyzed. Findings-By analyzing data it was possible to determine citizen satisfaction and to assess its relationship with different demographic characteristics. The results illustrate that gender does not significantly affect satisfaction, instead age, marital status, residence location (urban versus rural, income, education and occupational status of the respondents significantly affect satisfaction regarding local public communication. In addition, the findings confirm a relationship between the citizens' satisfaction and the age, income, education and occupational status of the respondents. Research limitations/implications- Owing to the budget and time limits, only a one-shot survey was conducted, therefore the comparison between “before” and “after” analysis could not be performed. In addition, further research should investigate the local public communication within national contexts. Practical implications -The adapted SERVQUAL scale may be used by institution managers to objectively assess communication performance and local authority service quality. Originality/value- There continues to be a lack of research regarding the communication process within local public administration and the effect of demographic predictors of communication satisfaction. This paper examines both the perceptions and the expectations of citizens regarding public communication. The results offer insights into residence location, age, income, education and occupational status effects on evaluations of communication satisfaction. Finally, the study contributes to studies of perceived service quality by bearing out

  3. Analysis and comparison. Bd. 1 - Longlife. Report on the analysis of state of technology, administrative and legal procedures, financial situation, demographic needs, similarities and differences in the participating countries Denmark, Germany, Lithuania, Poland and Russia. Formulations and benchmarks

    Energy Technology Data Exchange (ETDEWEB)

    Rueckert, Klaus (ed.)

    2010-07-01

    Environmental considerations are becoming one of the key features in the design when it comes to constructing modern, sustainable residential buildings. In an effort to streamline procedures and practices, the project Longlife has conducted a comparative review of these among the countries Denmark, Germany, Lithuania, Poland and Russia (associated organizations). The countries involved have shared knowledge and experiences with each other about how their respective building processes operate. These are collated and analysed. There are differences and commonness in the state of technology, administrative and legal procedures, financial situation, demographic needs, and how a 'housing project' functions. With this exercise Longlife has started to ensure that differences across the Baltic Sea Region will be minimised as regards environmentally-friendly residential constructions. This initial comparative stage covers planning, building permit and tendering procedures, practices for developing and operating housing and construction technologies. The report reflects the currently most applicable features of the participating countries' processes. Longlife project partners work in three competence teams to use the special know how and experiences and to cooperate in the public private partnership composition. The report analyses in the competence team 1 - Engineering and building technology, design standards - the engineering and technology standards in the countries Denmark, Germany, Lithuania, Poland and Russia. The report shows for the competence team 2 - Administration procedures, licensing rules, tendering rules, laws - the comparison and investigations of administration procedures, building permit rules, tendering rules and laws in the participating countries. The report provides for competence team 3 - Economical and financial basis - a general and a specific overview about economical and financial issues, sustainability and quality aspects in the

  4. Febrile Seizure: Demographic Features and Causative Factors

    Directory of Open Access Journals (Sweden)

    Hamed ESMAILI GOURABI

    2012-10-01

    Full Text Available ObjectiveBecause of geographical and periodical variation, we prompted to determine the demographic features and causative factors for febrile seizure in Rasht.Materials & MethodsIn this cross-sectional study, all 6–month- to 6-year-old children with the diagnosis of febrile seizure admitted to 17 Shahrivar hospital in Rasht, from August, 2009 to August, 2010 were studied. Age, sex, family history of the disease, seizure types, body temperature upon admission and infectious causes of the fever were recorded. All statistical analysis was performed with SPSS software, version 16.ResultsOf the 214 children (mean age, 25.24±15.40 months, 124 were boys and 109 had a positive family history. Complex seizures were seen in 39 cases. In patients with a complex febrile seizure, 59% had the repetitive type, 20.5% had the focal type and 20.5% had more than 15 minutes duration of seizures. Most of the repetitive seizures (78.3% occurred in patients under 2 years old; the difference between under and over 2-year-old patients was statistically significant (P=0.02. Study results did not show significant differences between the two genders for simple or complex seizures. The mean body temperature upon admission was 38.2±1.32◦C (38.31±0.82 degrees in boys and 38.04±1.78 in girls. Upper respiratory infections were seen in most patients (74.29%. All cases of lower respiratory infections were boys. There was a statistically significant difference between boys and girls in causes of fever.ConclusionMost of the children had a positive family history and the most common causative factor was upper respiratory infection.

  5. Retrospective analysis of the clinical and demographic variables on the outcomes after second-line treatment in advanced non-small cell lung cancer

    Directory of Open Access Journals (Sweden)

    Sourav Sau

    2013-01-01

    Full Text Available Background: Platinum based doublets chemotherapy are the standard of care for metastatic or advanced non-small cell lung carcinoma. This leads to modest survival advantage and improve quality-of-life. However, patients with advanced or metastatic disease eventually present disease progression and needs second-line systemic therapy in a selected group of patients or other supportive measures. There is very little knowledge available from the literature about the prognostic variables in patients, who receive second-line therapy. Materials and Methods: We retrospectively reviewed 329 patients received second-line treatment from July 2007 to September 2011 in the Department of Radiation Oncology, Burdwan Medical College and Hospital. For statistical analysis, 12 potential prognostic variables included. Univariate and multivariate regression analysis carried out to identify the prognostic variables associated with survival. Results: The results of univariate analysis for overall survival (OS and survival after second-line therapy identified to have prognostic significance: Age, sex, performance status, smoking history, serum lactate dehydrogenase, histopathology, first-line chemotherapy and its response and second-line therapy except the stage at diagnosis and site of failure after first-line therapy. The multivariate Cox regression analysis has shown that only performance and second-line therapy were independent prognostic variables for survival after second-line treatment and above these prognostic factors; age, smoking status and progression free survival also for OS. Conclusion: The performance status has shown consistent result as a prognostic factor in univariate and multivariate analysis for OS and survival after second-line therapy. These findings may also facilitate pretreatment prediction of survival and be used for selecting patients for the correct choice of cytotoxic therapy.

  6. Economic Growth, Demographic Change and Rural-Urban Migration in China

    Institute of Scientific and Technical Information of China (English)

    ZHONG Fu-ning; LI Qing; XIANG Jing; ZHU Jing

    2013-01-01

    Is China able to maintain fast growth after three decades? This paper tries to answer this question by:1) arguing that factors contributed to sustained long-run growth at supply side; 2) focusing on contributions of demographic dividend especially that of rural-urban migration; and 3) analyzing rural demographic change with information collected through village-wide household survey. Policy alternatives to realize remaining potential demographic dividend are proposed based on the analysis of changing rural demographic structure.

  7. Demographic Component-Support of Regional Economic Development. Case Study: Tecuci Plain

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    Iulian Sorcaru

    2012-02-01

    Full Text Available Regional economic development is strongly conditioned by the demographic component,the analysis of demographic trends and demographicprojections serving to substantiate properdevelopment plans and strategies. This study aims to determine the demographic trend of humansettlements in the Tecuci Plain, a space that can get the future status of micro-region, to identify thefavorability and/or restriction factors, to draw upuseful demographic projections for policy makers atlocal and regional level.

  8. 人口统计特征对酒店员工内在动机的影响--基于长沙市高星级酒店调查数据分析%Influence of Demographic Characteristics on Intrinsic Motivation of Hotel Employees---Based on the Analysis of High Stars Hotel Survey in Changsha City

    Institute of Scientific and Technical Information of China (English)

    曾丽艳; 周美芳; 周应兰

    2015-01-01

    Through 366 questionnaires answered by high star hotel employees in Changsha city,it tries to explore the reliability and validity of intrinsic motivation scale,and discusses the influence of demographic characteristic on intrinsic motivation by optimal scaling regression analysis.The results show that demographic characteristic has an important impact on the intrinsic motivation of hotel employees.Intrinsic motivation is most related to seniority, age and level of education,but gender has no significant influence on the intrinsic motivation.%通过对长沙市部分高星级酒店实施问卷调查获得的366份调查表,进行内在动机量表的信度与效度以及内在动机的最优尺度回归分析,得知人口统计特征变量对内在动机影响的相对重要性,在人口统计特征中,工龄对内在动机的影响最大,其次是年龄和受教育程度,性别对内在动机并无显著影响。

  9. Demographic Transformations of the Russian Regional Space

    Directory of Open Access Journals (Sweden)

    Elena Viktorovna Kurushina

    2015-07-01

    Full Text Available The paper considers the transformations of the quantitative components of human capital, which is the main driver of economic growth in the material, institutional and mental space. According to the author’s concept of stratified space, the processes of self-reproduction and self-renewal of a system are carried out in the material space. This can be determined by the indicators of fertility, mortality and migration in the demographic subsystem. The process of self-regulation of a system on the basis of legislative acts and behavior patterns is carried out in the institutional space. Institutional transformations are also manifested in the implementation of federal target programs for socio-economic development, affecting the state of the demographic subsystem. The processes of self-reflection, self-determination and self-development are carried out in the mental space. Mental transformations in the demographic subsystem are manifested in the change of value orientations. In accordance with the system of values that are conceptualized in modern development strategies the authors define the following models of Man: Economic Man, Socio-Economic Man (who lives in agglomeration centers and at the periphery, Socio-Natural Man (Environmental Man and Householder Man and Innovative Man. Demographic shifts are investigated in 83 Russian regions on the determinants of birth rate and mortality. The analyzed period of transformation covers 2005 and 2012. Methods of matrix analysis are used to visualize the process of demographic shifts. The assessment of transformation of the stratified regional space spheres is given on the basis of the multifactor models of the population natural growth rate. The paper reveals the reduction in the level and variation of mortality rate, the increasing importance and differentiation of regions according to fertility rate, and the effectiveness of introducing the institution of maternity capital from a perspective of the

  10. Depressive symptoms in the Netherlands 1975–1996 : a theoretical framework and an empirical analysis of socio-demographic characteristics, gender differences and changes over time

    NARCIS (Netherlands)

    Vivian Meertens, Vivian; Scheepers, Peer; Tax, Bert

    2003-01-01

    This article examines the longitudinal trend of depressive symptoms in the Netherlands, using large-scale national data recorded over the period 1975–1996. Our analyses showed fluctuations in the overall longitudinal trend. On the basis of a general theoretical framework, we formulated hypotheses

  11. Depressive symptoms in the Netherlands 1975–1996 : a theoretical framework and an empirical analysis of socio-demographic characteristics, gender differences and changes over time

    NARCIS (Netherlands)

    Vivian Meertens, Vivian; Scheepers, Peer; Tax, Bert

    2003-01-01

    This article examines the longitudinal trend of depressive symptoms in the Netherlands, using large-scale national data recorded over the period 1975–1996. Our analyses showed fluctuations in the overall longitudinal trend. On the basis of a general theoretical framework, we formulated hypotheses co

  12. Febrile Seizure: Demographic Features and Causative Factors

    Directory of Open Access Journals (Sweden)

    Hamed ESMAILI GOURABI

    2013-01-01

    Full Text Available How to cite this article: Esmaili Gourabi H, Bidabadi E, Cheraghalipour  F, Aarabi  Y, Salamat F. Febrile Seizure: Demographic Features and Causative Factors. Iran J Child Neurol Autumn 2012; 6(4:33-37.Abstract Objective Because of geographical and periodical variation, we prompted to determine the demographic features and causative factors for febrile seizure in Rasht. Materials & Methods In this cross-sectional study, all 6–month- to 6-year-old children with the diagnosis of febrile seizure admitted to 17 Shahrivar hospital in Rasht, from August, 2009 to August, 2010 were studied. Age, sex, family history of the disease, seizure types, body temperature upon admission and infectious causes of the fever were recorded. All statistical analysis was performed with SPSS software, version 16. Results Of the 214 children (mean age, 25.24±15.40 months, 124 were boys and 109 had a positive family history. Complex seizures were seen in 39 cases. In patients with a complex febrile seizure, 59% had the repetitive type, 20.5% had the focal type and 20.5% had more than 15 minutes duration of seizures. Most of the repetitive seizures (78.3% occurred in patients under 2 years old; the difference between under and over 2-year-old patients was statistically significant (P=0.02. Study results did not show significant differences between the two genders for simple or complex seizures. The mean body temperature upon admission was 38.2±1.32◦C (38.31±0.82 degrees in boys and 38.04±1.78 in girls. Upper respiratory infections were seen in most patients (74.29%. All cases of lower respiratory infections were boys. There was a statistically significant difference between boys and girls in causes of fever. Conclusion Most of the children had a positive family history and the most common causative factor was upper respiratory infection.  References: Huang MC, Huang CC, Thomas K. Febrile convulsions: development and validation of a questionnaire to measure

  13. Analysis of the development of selected indicators of the demographic statics and dynamics of the Czech Republic in 1993–2003

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    Milan Palát

    2005-01-01

    Full Text Available The paper is aimed at the presentation of findings obtained in the study of the average level, variability, dynamics, developmental trends and a short-time point extrapolation prediction of the population in the Czech Republic and their structure according to gender and scale of the economic generation. In addition to the exact evaluation of the selected indicators, the analysis is also aimed to general rates of natural reproduction of population and their movement in the defined territorial unit and time interval 1993–2003. There are also presented relative rates of marriages, divorces, live births and deaths to mid-year population.

  14. Gender in Science and Engineering Faculties: Demographic Inertia Revisited.

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    Nicole R Thomas

    Full Text Available The under-representation of women on faculties of science and engineering is ascribed in part to demographic inertia, which is the lag between retirement of current faculty and future hires. The assumption of demographic inertia implies that, given enough time, gender parity will be achieved. We examine that assumption via a semi-Markov model to predict the future faculty, with simulations that predict the convergence demographic state. Our model shows that existing practices that produce gender gaps in recruitment, retention, and career progression preclude eventual gender parity. Further, we examine sensitivity of the convergence state to current gender gaps to show that all sources of disparity across the entire faculty career must be erased to produce parity: we cannot blame demographic inertia.

  15. Gender in Science and Engineering Faculties: Demographic Inertia Revisited.

    Science.gov (United States)

    Thomas, Nicole R; Poole, Daniel J; Herbers, Joan M

    2015-01-01

    The under-representation of women on faculties of science and engineering is ascribed in part to demographic inertia, which is the lag between retirement of current faculty and future hires. The assumption of demographic inertia implies that, given enough time, gender parity will be achieved. We examine that assumption via a semi-Markov model to predict the future faculty, with simulations that predict the convergence demographic state. Our model shows that existing practices that produce gender gaps in recruitment, retention, and career progression preclude eventual gender parity. Further, we examine sensitivity of the convergence state to current gender gaps to show that all sources of disparity across the entire faculty career must be erased to produce parity: we cannot blame demographic inertia.

  16. Full likelihood analysis of genetic risk with variable age at onset disease--combining population-based registry data and demographic information.

    Directory of Open Access Journals (Sweden)

    Janne Pitkäniemi

    Full Text Available BACKGROUND: In genetic studies of rare complex diseases it is common to ascertain familial data from population based registries through all incident cases diagnosed during a pre-defined enrollment period. Such an ascertainment procedure is typically taken into account in the statistical analysis of the familial data by constructing either a retrospective or prospective likelihood expression, which conditions on the ascertainment event. Both of these approaches lead to a substantial loss of valuable data. METHODOLOGY AND FINDINGS: Here we consider instead the possibilities provided by a Bayesian approach to risk analysis, which also incorporates the ascertainment procedure and reference information concerning the genetic composition of the target population to the considered statistical model. Furthermore, the proposed Bayesian hierarchical survival model does not require the considered genotype or haplotype effects be expressed as functions of corresponding allelic effects. Our modeling strategy is illustrated by a risk analysis of type 1 diabetes mellitus (T1D in the Finnish population-based on the HLA-A, HLA-B and DRB1 human leucocyte antigen (HLA information available for both ascertained sibships and a large number of unrelated individuals from the Finnish bone marrow donor registry. The heterozygous genotype DR3/DR4 at the DRB1 locus was associated with the lowest predictive probability of T1D free survival to the age of 15, the estimate being 0.936 (0.926; 0.945 95% credible interval compared to the average population T1D free survival probability of 0.995. SIGNIFICANCE: The proposed statistical method can be modified to other population-based family data ascertained from a disease registry provided that the ascertainment process is well documented, and that external information concerning the sizes of birth cohorts and a suitable reference sample are available. We confirm the earlier findings from the same data concerning the HLA-DR3

  17. An analysis of the demographic profile, clinical manifestations, investigations and outcome of paediatric myelodysplastic syndrome: A single centre, cross-sectional study

    Directory of Open Access Journals (Sweden)

    Appaji Lingegowda

    2015-09-01

    Full Text Available Purpose: Pediatric myelodysplastic syndrome (MDS is a relatively rare entity, with distinct clinical features and more aggressive course than its adult counterpart. The aim of this study was to analyze the incidence of pediatric myelodysplastic syndrome at a tertiary cancer care center in southern India along with clinical manifestations, investigations and outcome.Methods: On retrospective analysis of 1094 cases of pediatric hematological malignancies over a five-year period from September 2009 to August 2014, a total of seven cases of pediatric myelodysplastic syndrome were identified. Presenting complaints, physical examination, investigations including haemogram, biochemistry, bone marrow examination and cytogenetics were reviewed. The diagnosis of MDS was made if there was dysplasia in at least 10% of cells in two or more cell lineages. All patients were risk stratified using the revised IPSS. Results: Out of 1094 cases of pediatric hematological malignancies presenting at our institute within the study period, there were only seven cases of pediatric MDS with an incidence of 0.65%. There were no genetic predispositions nor any cases of therapy related MDS. The most common presentation was with fever and all patients had significant splenomegaly. All patients had anemia (Median-6.2 gm / dL with elevated WBC counts (Median-30,900 / uL and thrombocytopenia (Median-50,000 / uL. The marrow cytogenetics was normal in five patients. Most patients fell into the high and very high-risk category of the revised IPSS, with only two patients of low risk. All seven patients were given only supportive care but one progressed to AML for which he was treated with remission induction. Only two patients were alive at the time of analysis and median survival was 9 months. Conclusion: Pediatric MDS is a rare disease with a short clinical history, aggressive course and generally poor outcomes as compared to the adult variant. A hematopoietic stem cell

  18. Fast demographic traits promote high diversification rates of Amazonian trees

    OpenAIRE

    Baker, Timothy R.; Pennington, R. Toby; Magallon, Susana; Gloor, Emanuel; Laurance, William F.; Alexiades, Miguel; Alvarez, Esteban; Araujo, Alejandro; Arets, Eric J. M. M.; Aymard, Gerardo; de Oliveira, Atila Alves; Amaral, Iêda; Arroyo, Luzmila; Bonal, Damien; Roel J.W. Brienen

    2014-01-01

    The Amazon rain forest sustains the world's highest tree diversity, but it remains unclear why some clades of trees are hyperdiverse, whereas others are not. Using dated phylogenies, estimates of current species richness and trait and demographic data from a large network of forest plots, we show that fast demographic traits - short turnover times - are associated with high diversification rates across 51 clades of canopy trees. This relationship is robust to assuming that diversification rat...

  19. Socio-Demographic Predictors of EFL Teacher Efficacy

    Directory of Open Access Journals (Sweden)

    Şenay YAVUZ

    2007-10-01

    Full Text Available Research on teachers’ beliefs and their impact on teacher cognition has been arelevant topic for educational inquiry for some decades. Teachers’ actions are tied totheir beliefs, perceptions, assumptions and motivation levels. Thus, research on teachers’beliefs is crucial in determining the way teachers understand and organize instruction.One important belief that appears to be an important influence on teacher and studentoutcomes is teacher efficacy. In accordance with this view and due to the increasingdemand for English as a foreign language education, the present study aimed to assessEFL teachers’ efficacy level and explore the socio-demographic predictors of teacherefficacy in an EFL setting, i.e., Turkey. 226 EFL teachers working at the preparatoryschools of public and private universities in Istanbul participated in this study. Data werecollected by means of quantitative methods; i.e., the Ohio State Teacher Efficacy Scale(adapted from Tschannen-Moran & Hoy, 2001 and the School-Level EnvironmentQuestionnaire (Fisher & Fraser, 1990.Data collected by means of these instruments weresubmitted to correlation and regression analysis and independent samples t-tests. Resultsof the study showed that the number of professional activities teachers were involved in,average number of students in teachers’ classes, working position, type of institution, andgender were the socio-demographic factors that predicted variations in EFL teachers’efficacy in this study.

  20. Genealogy and Demographic History of a Widespread Amphibian throughout Indochina.

    Science.gov (United States)

    Blair, Christopher; Davy, Christina M; Ngo, Andre; Orlov, Nikolai L; Shi, Hai-tao; Lu, Shun-qing; Gao, Lan; Rao, Ding-qi; Murphy, Robert W

    2013-01-01

    Relatively little is known about spatial patterns of cryptic diversity in tropical species and the processes that generate them. Few studies examine the geographic distribution of genetic lineages in Southeast Asia, an area hypothesized to harbor substantial cryptic diversity. We investigated the evolutionary history of Asian tree frogs of the Polypedates leucomystax complex (n = 172) based on 1800 bp of the mtDNA genes ND1 and cytochrome b and tested hypotheses pertaining to climate, geology, and dispersal patterns. Analyses revealed substantial genetic diversity and lineage divergence throughout the region with evidence for widespread sympatric lineages and a general north versus south clustering. Relaxed molecular clock analysis and tests for demographic expansion identified an initial cladogenesis during the Miocene with subsequent Plio-Pleistocene diversification, with the former corresponding to periods of increased aridity and the onset of monsoonal weather systems. Rates of diversification were relatively constant until the Early Pleistocene when rates increased exponentially. We found equivocal evidence for isolation-by-distance and a potential role of some landscape features as partial barriers to dispersal. Finally, our analyses showed that divergence between insular and mainland populations occurred before Homo sapiens colonized Southeast Asia, suggesting that historical human-mediated dispersal did not drive insular diversification. Our results suggested that demographic expansion in the Late Pleistocene resulted in widespread sympatric lineages in the P. leucomystax complex throughout southern China and Indochina and further clarified the evolutionary history of lineages within P. leucomystax.

  1. Genetic variation and demographic history of the Haplochromis laparogramma group of Lake Victoria-An analysis based on SINEs and mitochondrial DNA.

    Science.gov (United States)

    Mzighani, Semvua I; Nikaido, Masato; Takeda, Miyuki; Seehausen, Ole; Budeba, Yohana L; Ngatunga, Benjamin P; Katunzi, Egid F B; Aibara, Mitsuto; Mizoiri, Shinji; Sato, Tetsu; Tachida, Hidenori; Okada, Norihiro

    2010-01-15

    More than 500 endemic haplochromine cichlid species inhabit Lake Victoria. This striking species diversity is a classical example of recent explosive adaptive radiation thought to have happened within the last approximately 15,000 years. In this study, we examined the population structure and historical demography of 3 pelagic haplochromine cichlid species that resemble in morphology and have similar niche, Haplochromis (Yssichromis) laparogramma, Haplochromis (Y.) pyrrhocephalus, and Haplochromis (Y.) sp. "glaucocephalus". We investigated the sequences of the mitochondrial DNA control region and the insertion patterns of short interspersed elements (SINEs) of 759 individuals. We show that sympatric forms are genetically differentiated in 4 of 6 cases, but we also found apparent weakening of the genetic differentiation in areas with turbid water. We estimated the timings of population expansion and species divergence to coincide with the refilling of the lake at the Pleistocene/Holocene boundary. We also found that estimates can be altered significantly by the choice of the shape of the molecular clock. If we employ the nonlinear clock model of evolutionary rates in which the rates are higher towards the recent, the population expansion was dated at around the event of desiccation of the lake ca. 17,000 YBP. Thus, we succeeded in clarifying the species and population structure of closely related Lake Victoria cichlids and in showing the importance of applying appropriate clock calibrations in elucidating recent evolutionary events.

  2. Self-harm in children placed in a Court-Mandated Holding and Education Centre: analysis of socio-demographic variables and influence of implementation of judicial measures

    Directory of Open Access Journals (Sweden)

    G. García

    2015-10-01

    Full Text Available Objectives: To analyze and understand the existence of self-harming behavior in a detention centre for minors. Methods: Review of self-harm cases detected in a population of 94 inmates in 2013. Results: 26.5% of young offenders have conducted some form of self injury. 28% of individuals with self harming behaviors have more than 6 episodes over the period of internment. Self-beating is the most common type of self-harm performed by this group. Inmates serving sentences in the therapeutic section tend to present spillover effects in terms of self-injury. Discussion: The population held in prison show higher percentages of self-harm than amongst the general population. The chosen type of behavior is determined by the institution. Inmates that present greater mental fragility tend to perform these behaviors and in greater number.

  3. Self-harm in children placed in a Court-Mandated Holding and Education Centre: analysis of socio-demographic variables and influence of implementation of judicial measures.

    Science.gov (United States)

    García, G

    2015-01-01

    To analyze and understand the existence of self-harming behavior in a detention centre for minors. Review of self-harm cases detected in a population of 94 inmates in 2013. 26.5% of young offenders have conducted some form of self injury. 28% of individuals with self harming behaviors have more than 6 episodes over the period of internment. Self-beating is the most common type of self-harm performed by this group. Inmates serving sentences in the therapeutic section tend to present spillover effects in terms of self-injury. The population held in prison show higher percentages of self-harm than amongst the general population. The chosen type of behavior is determined by the institution. Inmates that present greater mental fragility tend to perform these behaviors and in greater number.

  4. Evolutionary shaping of demographic schedules

    Science.gov (United States)

    Wachter, Kenneth W.; Steinsaltz, David; Evans, Steven N.

    2014-01-01

    Evolutionary processes of natural selection may be expected to leave their mark on age patterns of survival and reproduction. Demographic theory includes three main strands—mutation accumulation, stochastic vitality, and optimal life histories. This paper reviews the three strands and, concentrating on mutation accumulation, extends a mathematical result with broad implications concerning the effect of interactions between small age-specific effects of deleterious mutant alleles. Empirical data from genomic sequencing along with prospects for combining strands of theory hold hope for future progress. PMID:25024186

  5. Socio-demographic characteristics affecting sport tourism choices: A structural model

    Directory of Open Access Journals (Sweden)

    Nataša Slak Valek

    2014-03-01

    Full Text Available Background: Effective tourism management in the field of sports tourism requires an understanding of differences in socioeconomic characteristics both within and between different market segments. Objective: In the broad tourism market demographic characteristics have been extensively analyzed for differences in destination choices, however little is known about demographic factors affecting sport tourists' decisions. Methods: A sample of Slovenian sports tourists was analyzed using data from a comprehensive survey of local and outbound tourist activity conducted by the Statistical Office of the Republic of Slovenia in 2008. After data weighting the information for 353,783 sports related trips were available for analysis. The research model adopted suggests that four socio-demographic characteristics (gender, age, level of education and income significantly affect a tourist's choice of sports related travel either locally within Slovenia or to a foreign country. Furthermore the destination (local or foreign has an influence on the choice of the type of accommodation selected and the tourist's total expenditure for the trip. For testing the first part of our model (the socio-demographic characteristics effects a linear regression was used, and for the final part of the model (the selection of accommodation type and travel expenditure t-test were applied. Results: The result shows the standardized β regression coefficients are all statistically significant at the .001 level for the tested socio-demographic characteristics and also the overall regression model was statistically significant at .001 level. Conclusions: With these results the study confirmed that all the selected socio-demographic characteristics have a significant influence on the sport-active tourist when choosing between a domestic and foreign tourism destination which in turn affect the type of accommodation chosen and the level of expenditure while travelling.

  6. Investigating Research Gaps of Pharmaceutical take back Events: An Analysis of take back Program Participants' Socioeconomic, Demographic, and Geographic Characteristics and the Public Health Benefits of take back Programs

    Science.gov (United States)

    Stoddard, K. I.; Hodge, V.; Maxey, G.; Tiwari, C.; Cready, C.; Huggett, D. B.

    2017-06-01

    Research continues to show that pharmaceutical environmental contamination causes adverse effects to aquatic life. There are also public health risks associated with pharmaceuticals because in-home reserves of medications provide opportunities for accidental poisoning and intentional medication abuse. Pharmaceutical take back programs have been seen as a potential remedy for these issues; however, a thorough review of past programs indicates limited research has been conducted on take back programs. Furthermore, there are significant gaps in take back program research. To address these gaps and ultimately determine if take back programs could improve public health, research was conducted in conjunction with the take back program Denton drug disposal days held in Denton, Texas. Socioeconomic, demographic, and geographic characteristics of Denton drug disposal days participants were investigated using surveys and Geographic Information Systems. Potential impacts of the Denton drug disposal days program on public health were determined by comparing data from Denton drug disposal days events with data supplied by the North Texas Poison Center. Results suggest that Denton drug disposal days events may have prevented accidental poisonings or intentional abuse, however only qualitative comparisons support this statement and there was insufficient empirical evidence to support the conclusion that Denton drug disposal days events were exclusively responsible for public health improvements. An interesting finding was that there was a definitive travel threshold that influenced participation in Denton drug disposal days events. Overall, this study fills some geographic, socioeconomic, and demographic data gaps of take back programs and proposes methods to analyze and improve participation in future take back programs. These methods could also be applied to improve participation in other local environmentally-focused programs such as household hazardous collection events.

  7. Chemometric analysis of chromatographic fingerprints shows potential of Cyclopia maculata (Andrews) Kies for production of standardized extracts with high xanthone content.

    Science.gov (United States)

    Schulze, Alexandra E; de Beer, Dalene; de Villiers, André; Manley, Marena; Joubert, Elizabeth

    2014-10-29

    Cyclopia species are used for the production of honeybush tea and food ingredient extracts associated with many health benefits. A species-specific high-performance liquid chromatography (HPLC) method for Cyclopia maculata, developed and validated, allowed quantification of the major compounds in extracts from "unfermented" and fermented C. maculata. Two xanthones were tentatively identified for the first time in a Cyclopia species, whereas an additional four compounds were tentatively identified for the first time in C. maculata. "Fermentation" (oxidation) decreased the content of all compounds, with the exception of vicenin-2. Similarity analysis of the chromatographic fingerprints of unfermented C. maculata aqueous extracts showed extremely low variation (r ≥ 0.97) between samples. Some differences between wild-harvested and cultivated seedling plants were, however, demonstrated using principal component analysis. Quantitative data of selected compounds confirmed the low level of variation, making this Cyclopia species ideal for the production of standardized food ingredient extracts.

  8. An analysis of the relationship between burnout, socio-demographic and workplace factors and job satisfaction among emergency department health professionals.

    Science.gov (United States)

    Tarcan, Menderes; Hikmet, Neşet; Schooley, Benjamin; Top, Mehmet; Tarcan, Gamze Yorgancıoglu

    2017-04-01

    Burnout among emergency medical practitioners and personnel negatively affects career satisfaction and job performance and can lead to mental health issues, including anxiety, depression, and suicide. This study investigated the relationship between the perceptions of burnout and job satisfaction of those working in two different hospital's emergency departments assessing the effect of burnout dimensions and additional factors (age, position, marital status, annual income, employment type, gender, patient encounters, and household economic well-being) on job satisfaction. This study addresses a gap in the literature of the relationships between a) burnout and job satisfaction of emergency department's health care personnel (physicians, nurses, technicians) and b) the factors that are associated with emergency department employees' job satisfaction. A cross-sectional survey of two hundred and fifty participants was interviewed, using validated instruments (the Maslach Burnout Scale and the Minnesota Satisfaction Questionnaire). Participants include 38 physicians, 89 nurses, and 84 medical technicians, and 39 information technicians. The Maslach Burnout Inventory Scale, which assesses emotional exhaustion (EE), depersonalization (DP) and personal accomplishment (PA), and the Minnesota Satisfaction Questionnaire (MSQ), which assesses intrinsic satisfaction (IS), extrinsic satisfaction (ES) and overall satisfaction (OS), were used for data collection. Study findings indicate that significant relationship exists between burnout and job satisfaction; annual income and household economic-well-being had a positive association with job satisfaction, whereas gender, age, education, marital status had no significant effect on any form of satisfaction. Moreover, this study reveals that emotional exhaustion (EE) is a significant predictor of all three dimensions of job satisfaction while depersonalization (DP) had no significant showing. Results of this study suggest that it is

  9. Demographic Trends in the European Union: Political and Strategic Implications

    Science.gov (United States)

    2004-06-01

    International Institute for Applied Systems Analysis (IIASA), in Laxenburg, Austria, concluded that the current...Delays in Childbearing make a Big Difference for the Birth Rate,” International Institute for Applied Systems Analysis , Office of Information, 27 March...its Demographic Evolution, Delays in Childbearing make a Big Difference for the Birth Rate.” International Institute for Applied Systems

  10. Hippocampal gene expression analysis using the ORESTES methodology shows that homer 1a mRNA is upregulated in the acute period of the pilocarpine epilepsy model.

    Science.gov (United States)

    Avedissian, Marcelo; Longo, Beatriz M; Jaqueta, Carolina B; Schnabel, Beatriz; Paiva, Paulo B; Mello, Luiz Eugênio A M; Briones, Marcelo R S

    2007-01-01

    In the study of temporal lobe epilepsy (TLE) the characterization of genes expressed in the hippocampus is of central importance for understanding their roles in epileptogenic mechanisms. Although several large-scale studies on TLE gene expression have been reported, precise assignment of individual genes associated with this syndrome is still debatable. Here we investigated differentially expressed genes by comparison of mRNAs from normal and epileptic rat hippocampus in the pilocarpine model of epilepsy. For this we used a powerful EST sequencing methodology, ORESTES (Open Reading frame Expressed Sequence Tags), which generates sequence datasets enriched for mRNAs open reading frames (ORFs) rather than simple 5' and 3' ends of mRNAs. Analysis of our sequences shows that ORESTES readily enables the identification of epilepsy associated ORFs. PFAM analysis of protein motifs present in our ORESTES epilepsy database revealed diverse important protein family domains, such as cytoskeletal, cell signaling and protein kinase domains, which could be involved in processes underlying epileptogenesis. More importantly, we show that the expression of homer 1a, known to be coupled to mGluR and NMDA synaptic transmission, is associated with pilocarpine induced status epilepticus (SE). The combined use of the pilocarpine model of epilepsy with the ORESTES technique can significantly contribute to the identification of specific genes and proteins related to TLE. This is the first study applying a large-scale method for rapid shotgun sequencing directed to ORFs in epilepsy research.

  11. Gene network analysis shows immune-signaling and ERK1/2 as novel genetic markers for multiple addiction phenotypes: alcohol, smoking and opioid addiction.

    Science.gov (United States)

    Reyes-Gibby, Cielito C; Yuan, Christine; Wang, Jian; Yeung, Sai-Ching J; Shete, Sanjay

    2015-06-05

    Addictions to alcohol and tobacco, known risk factors for cancer, are complex heritable disorders. Addictive behaviors have a bidirectional relationship with pain. We hypothesize that the associations between alcohol, smoking, and opioid addiction observed in cancer patients have a genetic basis. Therefore, using bioinformatics tools, we explored the underlying genetic basis and identified new candidate genes and common biological pathways for smoking, alcohol, and opioid addiction. Literature search showed 56 genes associated with alcohol, smoking and opioid addiction. Using Core Analysis function in Ingenuity Pathway Analysis software, we found that ERK1/2 was strongly interconnected across all three addiction networks. Genes involved in immune signaling pathways were shown across all three networks. Connect function from IPA My Pathway toolbox showed that DRD2 is the gene common to both the list of genetic variations associated with all three addiction phenotypes and the components of the brain neuronal signaling network involved in substance addiction. The top canonical pathways associated with the 56 genes were: 1) calcium signaling, 2) GPCR signaling, 3) cAMP-mediated signaling, 4) GABA receptor signaling, and 5) G-alpha i signaling. Cancer patients are often prescribed opioids for cancer pain thus increasing their risk for opioid abuse and addiction. Our findings provide candidate genes and biological pathways underlying addiction phenotypes, which may be future targets for treatment of addiction. Further study of the variations of the candidate genes could allow physicians to make more informed decisions when treating cancer pain with opioid analgesics.

  12. The fading affect bias shows positive outcomes at the general but not the individual level of analysis in the context of social media.

    Science.gov (United States)

    Gibbons, Jeffrey A; Horowitz, Kyle A; Dunlap, Spencer M

    2017-08-01

    Unpleasant affect fades faster than pleasant affect (e.g., Walker, Vogl, & Thompson, 1997); this effect is referred to as the Fading Affect Bias (FAB; Walker, Skowronski, Gibbons, Vogl, & Thompson, 2003a). Research shows that the FAB is consistently related to positive/healthy outcomes at a general but not at a specific level of analysis based on event types and individual differences (e.g., Gibbons et al., 2013). Based on the positive outcomes for FAB and negative outcomes for social media (Bolton et al., 2013; Huang, 2010), the current study examined FAB in the context of social media events along with related individual differences. General positive outcomes were shown in the form of robust FAB effects across social media and non-social media events, a larger FAB for non-social media events than for social media events, negative correlations of FAB with depression, anxiety, and stress as well as a positive correlation of FAB with self-esteem. However, the lack of a negative correlation between FAB and anxiety for social media events in a 3-way interaction did not show positive outcomes at a specific level of analysis. Rehearsal ratings mediated the 3-way interaction. Implications are discussed. Copyright © 2017 Elsevier Inc. All rights reserved.

  13. 基于RMP分析的泉州木偶戏旅游开发%Development of Quanzhou Puppet Show Based on RMP Analysis

    Institute of Scientific and Technical Information of China (English)

    林炜铃; 陈金华

    2011-01-01

    基于昂普(RMP)分析模式,从资源(Resource)、市场(Market)和产品(Product)三方面对泉州木偶戏旅游进行系统的评价分析,认为泉州木偶戏历史与文化意义深远、拥有显著的地域特色、广泛的戏剧市场、旅游价值极高,但目前木偶戏的旅游市场份额不足。文中提出木偶戏与创意产业联合开发、木偶戏产品空间组合开发、木偶戏推介方式多样化等三个方面的开发设想。同时提出以智力开路、官员推进、政府主导为主要手段的木偶戏旅游开发保障措施。%This article makes a complete estimate analysis on the tourism resource of Quanzhou Puppet show's estimate from the resource,the market and the product based on the RMP analysis.It displays there is a profound history and culture,prominent regional features,wide drama markets and high tourism value in Quanzhou puppet show,but a short tourism market share at the moment.This article points out a development assume on the united development of puppet show and created industry,the space combination development of puppetoon product and the various introduction of puppet show.As suggested at the same time that to develop created?tourism by intellect,official and government as guarantee measures of tourism development.

  14. DEMOGRAPHIC FACTOR OF ECOLOGICAL POLICY

    OpenAIRE

    2015-01-01

    Demographic factor of ecological policy is analyzed. Анализируется демографическая составляющая экологической политики. Аналізується демографічна складова екологічної політики.

  15. Using Computed Tomography Scans and Patient Demographic Data to Estimate Thoracic Epidural Space Depth

    Directory of Open Access Journals (Sweden)

    Alyssa Kosturakis

    2015-01-01

    Full Text Available Background and Objectives. Previous studies have used varying methods to estimate the depth of the epidural space prior to placement of an epidural catheter. We aim to use computed tomography scans, patient demographics, and vertebral level to estimate the depth of the loss of resistance for placement of thoracic epidural catheters. Methods. The records of consecutive patients who received a thoracic epidural catheter were reviewed. Patient demographics, epidural placement site, and technique were collected. Preoperative computed tomography scans were reviewed to measure the skin to epidural space distance. Linear regression was used for a multivariate analysis. Results. The records of 218 patients were reviewed. The mean loss of resistance measurement was significantly larger than the mean computed tomography epidural space depth measurement by 0.79 cm (p<0.001. Our final multivariate model, adjusted for demographic and epidural technique, showed a positive correlation between the loss of resistance and the computed tomography epidural space depth measurement (R2=0.5692, p<0.0001. Conclusions. The measured loss of resistance is positively correlated with the computed tomography epidural space depth measurement and patient demographics. For patients undergoing thoracic or abdominal surgery, estimating the loss of resistance can be a valuable tool.

  16. Demographic Ageing on Croatian Islands

    Directory of Open Access Journals (Sweden)

    Ivo Nejašmić

    2013-08-01

    Full Text Available This paper analyses the changes in the population structure of the Croatian islands by age, warns of the degree of ageing, provides spatial differentiation of this process and presents perspective of ageing at the level of settlement. Typing of population ageing is based on scores and has seven types. The total island population in 2011 belongs to the type 5 – very old population. Almost a half of the settlements (out of 303 have been affected by the highest levels of ageing (types 6 and 7. It was found that a quarter of island settlements will become “dead villages” in a foreseeable future; most of them are on small islands but also in the interior of larger islands. These are villages decaying in every respect, in which the way of life, as we know it, veins and goes out. The present ageing villagers are their last residents in most cases. Eve¬rything suggests that demographic recovery of the islands is not possible with the forces in situ. It is important to strike a balance between the needs and opportunities in order to successfully organize life on the islands, both small and large ones, and the fact is that there is a continuing disparity, which is especially profound in small islands. A sensitive and selective approach is needed to overcome the unfavourable demographic trends. Therefore it is necessary to respect the particularities of indi¬vidual islands and island groups in devising development strategy. Solutions to the problems must come of the local and wider community in synergy with relevant professional and scientific institutions. However, if the solutions are not found or measures do not give results, if the islands are left to desorganisation and senilisation, a part of the islands will become a wasteland. With regard to the value of this area whose wealth are people in the first place, this would be an intolerable civilization decline.

  17. [[Demographic analysis of the first marriage process

    Science.gov (United States)

    Kaneko, R

    1991-10-01

    The author analyzes the stages leading to first marriage in Japan, using data concerning the period 1905-1955 to illustrate probability models and life table methods. Factors taken into consideration include type of marriage (choice or arranged), heterogeneity, and waiting times. A trend in marriage postponement at the outbreak of World War II and a decline in marriage age in the postwar period are noted. (SUMMARY IN ENG)

  18. Demographic Characteristics of World Class Jamaican Sprinters

    Directory of Open Access Journals (Sweden)

    Rachael Irving

    2013-01-01

    Full Text Available The dominance of Jamaican sprinters in international meets remains largely unexplained. Proposed explanations include demographics and favorable physiological characteristics. The aim of this study was to analyze the demographic characteristics of world class Jamaican sprinters. Questionnaires administered to 120 members of the Jamaican national team and 125 controls elicited information on place of birth, language, ethnicity, and distance and method of travel to school. Athletes were divided into three groups based on athletic disciplines: sprint (s: 100–400 m; n=80, jump and throw (j/t: jump and throw; n=25 and, middle distance (md: 800–3000 m; n=15. Frequency differences between groups were assessed using chi-square tests. Regional or county distribution of sprint differed from that of middle distance (P<0.001 but not from that of jump and throw athletes (P=0.24 and that of controls (P=0.59. Sprint athletes predominately originated from the Surrey county (s = 46%, j/t = 37%, md = 17, C = 53%, whilst middle distance athletes exhibited excess from the Middlesex county (md = 60%. The language distribution of all groups showed uniformity with a predominance of English. A higher proportion of middle distance and jump and throw athletes walked to school (md = 80%, j/t = 52%, s = 10%, and C = 12% and travelled greater distances to school. In conclusion, Jamaica’s success in sprinting may be related to environmental and social factors.

  19. Spatial Associations Between Contaminated Land and Socio Demographics in Ghana.

    Science.gov (United States)

    Dowling, Russell; Ericson, Bret; Caravanos, Jack; Grigsby, Patrick; Amoyaw-Osei, Yaw

    2015-10-27

    Associations between contaminated land and socio demographics are well documented in high-income countries. In low- and middle-income countries, however, little is known about the extent of contaminated land and possible demographic correlations. This is an important yet sparsely researched topic with potentially significant public health implications as exposure to pollution remains a leading source of morbidity and mortality in low-income countries. In this study, we review the associations between several socio demographic factors (population, population density, unemployment, education, and literacy) and contaminated sites in Ghana. Within this context, both correlation and association intend to show the relationship between two variables, namely contaminated sites and socio demographics. Aggregated district level 2010 census data from Ghana Statistical Service and contaminated site location data from Pure Earth's Toxic Sites Identification Program (TSIP) were spatially evaluated using the number of sites per kilometer squared within districts as the unit of measurement. We found a low to medium positive correlation (ρ range: 0.285 to 0.478) between contaminated sites and the following socio demographics: higher population density, higher unemployment, greater education, and higher literacy rate. These results support previous studies and suggest that several socio demographic factors may be reasonably accurate predictors of contaminated site locations. More research and targeted data collection is needed to better understand these associations with the ultimate goal of developing a predictive model.

  20. Spatial Associations Between Contaminated Land and Socio Demographics in Ghana

    Directory of Open Access Journals (Sweden)

    Russell Dowling

    2015-10-01

    Full Text Available Associations between contaminated land and socio demographics are well documented in high-income countries. In low- and middle-income countries, however, little is known about the extent of contaminated land and possible demographic correlations. This is an important yet sparsely researched topic with potentially significant public health implications as exposure to pollution remains a leading source of morbidity and mortality in low-income countries. In this study, we review the associations between several socio demographic factors (population, population density, unemployment, education, and literacy and contaminated sites in Ghana. Within this context, both correlation and association intend to show the relationship between two variables, namely contaminated sites and socio demographics. Aggregated district level 2010 census data from Ghana Statistical Service and contaminated site location data from Pure Earth’s Toxic Sites Identification Program (TSIP were spatially evaluated using the number of sites per kilometer squared within districts as the unit of measurement. We found a low to medium positive correlation (ρ range: 0.285 to 0.478 between contaminated sites and the following socio demographics: higher population density, higher unemployment, greater education, and higher literacy rate. These results support previous studies and suggest that several socio demographic factors may be reasonably accurate predictors of contaminated site locations. More research and targeted data collection is needed to better understand these associations with the ultimate goal of developing a predictive model.

  1. Evaluation of socio-demographic variables affecting the periodontal health of pregnant women in Chandigarh, India

    Science.gov (United States)

    Dhaliwal, Jagjit Singh; Lehl, Gurvanit; Sodhi, Sachinjeet K.; Sachdeva, Sonia

    2013-01-01

    Background: The literature is replete with reports that pregnant women have an increased level of periodontal disease as compared with non-pregnant women of the same age. There are many studies correlating the effect of periodontal disease on the adverse pregnancy outcomes. The development of periodontal diseases during pregnancy can be influenced by factors such as preexisting oral conditions, general health, and socio-cultural background. There is very little data studying the effect of socio-demographic factors on the periodontal health of pregnant women. This study evaluated the periodontal status of a sample of pregnant women of Chandigarh and adjoining areas. The study also investigated the relationship between these variables and a series of demographic and clinical variables. Materials and Methods: The participants were 190 pregnant women attending Gynecology and Obstetrics outpatient department of Government Medical College and Hospital, Chandigarh. The participants were examined for their periodontal health and various socio-demographic variables were recorded on performas designed for the purpose of study. Statistical analysis was done. Results: The results revealed that the mean bleeding index scores and probing depth increased with statistical significance when the socio-economic status was lower (P0.1). The plaque index was not significantly associated with the socio-economic status, profession, place of residence, and trimester of pregnancy (P>0.1). Conclusion: In the population of pregnant women investigated under this study, the clinical and socio-demographic characteristics showed non-significant correlation except socio-economic status which showed statistically significant correlation with bleeding on probing and pocket depth. Further studies may be required in Indian population to determine the association of periodontal diseases in pregnant women with socio-demographic variables. PMID:23633773

  2. Characterisation of UK diets according to degree of food processing and associations with socio-demographics and obesity: cross-sectional analysis of UK National Diet and Nutrition Survey (2008-12).

    Science.gov (United States)

    Adams, Jean; White, Martin

    2015-12-18

    Food processing alters food from its natural state for safety, convenience, taste or palatability. Previous research suggests that industrially processed foods, and diets high in these products, tend to be less healthful. However, most previous work is based on household, rather than individual-level, data. Little has been reported on the relationship between processed food consumption and markers of health; or on socio-demographic correlates of processed food consumption. Our objective was to describe: the nutritional content of foods classified according to degree of processing; the nutritional content of diets with different relative intakes of processed foods; the socio-demographic characteristics of individuals with different relative intakes of processed foods; and the association between intake of processed foods and body weight. Secondary analysis of data from the UK National Diet and Nutrition Survey (2008-12), a large national cross-sectional study of diet. Dietary information was collected using four-day, unweighed, food-diaries. Foods were classified as: unprocessed or minimally processed (MPF; foods with no processing or mostly physical processes applied to single whole foods), processed ingredients (PI; extracted and purified components of single whole foods), or ultra-processed food products (UPF; products produced from industrial combining of MPF and PI). Two thousand one hundred seventy four adults were included. MPF and diets high in these foods, had the most healthful nutritional profile. UPF did not necessarily have the least healthful nutritional profile, but diets high in these foods did. Women, and older adults consumed more energy from MPF, and less from UPF. Those living in lower occupation social class households consumed less energy from MPF, but no more from UPF. Only higher intake of PI was consistently, inversely, associated with body weight. This is the first study to explore correlates of processed food consumption, using individual

  3. A propensity score analysis shows that empirical treatment with linezolid does not increase the thirty-day mortality rate in patients with Gram-negative bacteremia.

    Science.gov (United States)

    Ternavasio-de la Vega, Hugo-Guillermo; Mateos-Díaz, Ana-María; Martinez, Jose-Antonio; Almela, Manel; Cobos-Trigueros, Nazaret; Morata, Laura; De-la-Calle, Cristina; Sala, Marta; Mensa, Josep; Marcos, Miguel; Soriano, Alex

    2014-12-01

    The role of linezolid in empirical therapy of suspected bacteremia remains unclear. The aim of this study was to evaluate the influence of empirical use of linezolid or glycopeptides in addition to other antibiotics on the 30-day mortality rates in patients with Gram-negative bacteremia. For this purpose, 1,126 patients with Gram-negative bacteremia in the Hospital Clinic of Barcelona from 2000 to 2012 were included in this study. In order to compare the mortality rates between patients who received linezolid or glycopeptides, the propensity scores on baseline variables were used to balance the treatment groups, and both propensity score matching and propensity-adjusted logistic regression were used to compare the 30-day mortality rates between the groups. The overall 30-day mortality rate was 16.0% during the study period. Sixty-eight patients received empirical treatment with linezolid, and 1,058 received glycopeptides. The propensity score matching included 64 patients in each treatment group. After matching, the mortality rates were 14.1% (9/64) in patients who received glycopeptides and 21.9% (14/64) in those who received linezolid, and a nonsignificant association between empirical linezolid treatment and mortality rate (odds ratio [OR], 1.63; 95% confidence interval [CI], 0.69 to 3.82; P = 0.275, McNemar's test) was found. This association remained nonsignificant when variables that remained unbalanced after matching were included in a conditional logistic regression model. Further, the stratified propensity score analysis did not show any significant relationship between empirical linezolid treatment and the mortality rate after adjustment by propensity score quintiles or other variables potentially associated with mortality. In conclusion, the propensity score analysis showed that empirical treatment with linezolid compared with that with glycopeptides was not associated with 30-day mortality rates in patients with Gram-negative bacteremia.

  4. Analysis of conservative tracer measurement results using the Frechet distribution at planted horizontal subsurface flow constructed wetlands filled with coarse gravel and showing the effect of clogging processes.

    Science.gov (United States)

    Dittrich, Ernő; Klincsik, Mihály

    2015-11-01

    A mathematical process, developed in Maple environment, has been successful in decreasing the error of measurement results and in the precise calculation of the moments of corrected tracer functions. It was proved that with this process, the measured tracer results of horizontal subsurface flow constructed wetlands filled with coarse gravel (HSFCW-C) can be fitted more accurately than with the conventionally used distribution functions (Gaussian, Lognormal, Fick (Inverse Gaussian) and Gamma). This statement is true only for the planted HSFCW-Cs. The analysis of unplanted HSFCW-Cs needs more research. The result of the analysis shows that the conventional solutions (completely stirred series tank reactor (CSTR) model and convection-dispersion transport (CDT) model) cannot describe these types of transport processes with sufficient accuracy. These outcomes can help in developing better process descriptions of very difficult transport processes in HSFCW-Cs. Furthermore, a new mathematical process can be developed for the calculation of real hydraulic residence time (HRT) and dispersion coefficient values. The presented method can be generalized to other kinds of hydraulic environments.

  5. First multigene analysis of Archamoebae (Amoebozoa: Conosa) robustly reveals its phylogeny and shows that Entamoebidae represents a deep lineage of the group.

    Science.gov (United States)

    Pánek, Tomáš; Zadrobílková, Eliška; Walker, Giselle; Brown, Matthew W; Gentekaki, Eleni; Hroudová, Miluše; Kang, Seungho; Roger, Andrew J; Tice, Alexander K; Vlček, Čestmír; Čepička, Ivan

    2016-05-01

    Archamoebae is an understudied group of anaerobic free-living or endobiotic protists that constitutes the major anaerobic lineage of the supergroup Amoebozoa. Hitherto, the phylogeny of Archamoebae was based solely on SSU rRNA and actin genes, which did not resolve relationships among the main lineages of the group. Because of this uncertainty, several different scenarios had been proposed for the phylogeny of the Archamoebae. In this study, we present the first multigene phylogenetic analysis that includes members of Pelomyxidae, and Rhizomastixidae. The analysis clearly shows that Mastigamoebidae, Pelomyxidae and Rhizomastixidae form a clade of mostly free-living, amoeboid flagellates, here called Pelobiontida. The predominantly endobiotic and aflagellated Entamoebidae represents a separate, deep-branching lineage, Entamoebida. Therefore, two unique evolutionary events, horizontal transfer of the nitrogen fixation system from bacteria and transfer of the sulfate activation pathway to mitochondrial derivatives, predate the radiation of recent lineages of Archamoebae. The endobiotic lifestyle has arisen at least three times independently during the evolution of the group. We also present new ultrastructural data that clarifies the primary divergence among the family Mastigamoebidae which had previously been inferred from phylogenetic analyses based on SSU rDNA.

  6. Single Molecule Analysis of the Arabidopsis FRA1 Kinesin Shows that It Is a Functional Motor Protein with Unusually High Processivity

    Institute of Scientific and Technical Information of China (English)

    Chuanmei Zhu; Ram Dixit

    2011-01-01

    The Arabidopsis FRA1 kinesin contributes to the organization of cellulose microfibrils through an unknown mechanism.The cortical localization of this kinesin during interphase raises the possibility that it transports cell wallrelated cargoes along cortical microtubules that either directly or indirectly influence cellulose microfibril patterning.To determine whether FRA1 is an authentic motor protein,we combined bulk biochemical assays and single molecule fluorescence imaging to analyze the motor properties of recombinant,GFP-tagged FRA1 containing the motor and coiled-coil domains (designated as FRA1(707)-GFP).We found that FRA1(707)-GFP binds to microtubules in an ATP-dependent manner and that its ATPase activity is dramatically stimulated by the presence of microtubules.Using single molecule studies,we found that FRA1(707)-GFP moves processively along microtubule tracks at a velocity of about 0.4 μm s-1.In addition,we found that FRA1(707)-GFP is a microtubule plus-end-directed motor and that it moves along microtubules as a dimer.Interestingly,our single molecule analysis shows that the processivity of FRA1(707)-GFP is at least twice the processivity of conventional kinesin,making FRA1 the most processive kinesin to date.Together,our data show that FRA1 is a bona fide motor protein that has the potential to drive long-distance transport of cargo along cortical microtubules.

  7. An Analysis of Trafficking Receptors Shows that CD44 and P-Selectin Glycoprotein Ligand-1 Collectively Control the Migration of Activated Human T-Cells

    KAUST Repository

    Ali, Amal J.

    2017-05-03

    Selectins guide the traffic of activated T-cells through the blood stream by mediating their tethering and rolling onto inflamed endothelium, in this way acting as beacons to help navigate them to sites of inflammation. Here, we present a comprehensive analysis of E-selectin ligands expressed on activated human T-cells. We identified several novel glycoproteins that function as E-selectin ligands. Specifically, we compared the role of P-selectin glycoprotein ligand-1 (PSGL-1) and CD43, known E-selectin ligands, to CD44, a ligand that has not previously been characterized as an E-selectin ligand on activated human T-cells. We showed that CD44 acts as a functional E-selectin ligand when expressed on both CD4+ and CD8+ T-cells. Moreover, the CD44 protein carries a binding epitope identifying it as hematopoietic cell E- and/or L-selectin ligand (HCELL). Furthermore, by knocking down these ligands individually or together in primary activated human T-cells, we demonstrated that CD44/HCELL, and not CD43, cooperates with PSGL-1 as a major E-selectin ligand. Additionally, we demonstrated the relevance of our findings to chronic autoimmune disease, by showing that CD44/HCELL and PSGL-1, but not CD43, from T-cells isolated from psoriasis patients, bind E-selectin.

  8. Analysis of large new South African dataset using two host-specificity indices shows generalism in both adult and larval ticks of mammals.

    Science.gov (United States)

    Espinaze, Marcela P A; Hellard, Eléonore; Horak, Ivan G; Cumming, Graeme S

    2016-03-01

    Ticks and tick-borne pathogens can have considerable impacts on the health of livestock, wildlife and people. Knowledge of tick-host preferences is necessary for both tick and pathogen control. Ticks were historically considered as specialist parasites, but the range of sampled host species has been limited, infestation intensity has not been included in prior analyses, and phylogenetic distances between hosts have not been previously considered. We used a large dataset of 35 604 individual collections and two host-specificity indices to assess the specificity of 61 South African tick species, as well as distinctions between adult and juvenile ticks, for 95 mammalian hosts. When accounting for host phylogeny, most adult and juvenile ticks behaved as generalists, with juveniles being significantly more generalist than adults. When we included the intensity of tick infestation, ticks exhibited a wider diversity of specificity in all life stages. Our results show that ticks of mammals in South Africa tend to behave largely as generalists and that adult ticks are more host-specific. More generally, our analysis shows that the incorporation of life-stage differences, infestation intensity and phylogenetic distances between hosts, as well as the use of more than one specificity index, can all contribute to a deeper understanding of host-parasite interactions.

  9. Geriatric trauma: demographics, injuries, and mortality.

    Science.gov (United States)

    Keller, Julie M; Sciadini, Marcus F; Sinclair, Elizabeth; O'Toole, Robert V

    2012-09-01

    To identify injuries that elderly sustain during high-energy trauma and determine which are associated with mortality. Retrospective review of prospectively collected database. Academic trauma center. Patients selected from database of all trauma admissions from January 2004 through June 2009. Study population consisted of patients directly admitted from scene of injury who sustained high-energy trauma with at least one orthopaedic injury and were 65 years or older (n = 597). Review of demographics, trauma markers, injuries, and disposition statuses. Statistical analysis using χ test, Student t test, and logistic regression analysis. The most common fractures were of the rib, distal radius, pelvic ring, facial bones, proximal humerus, clavicle, ankle, and sacrum. The injuries associated with the highest mortality rates were fractures of the cervical spine with neurological deficit (47%), at the C2 level (44%), and of the proximal femur (25%), pelvic ring (25%), clavicle (24%), and distal humerus (24%). The fractures significantly associated with mortality were fractures of the clavicle (P = 0.001), foot joints (P = 0.001), proximal humerus or shaft and head of the humerus (P = 0.002), sacroiliac joint (P = 0.004), and distal ulna (P = 0.002). Elderly patients present with significantly worse injuries, remain in the hospital longer, require greater use of resources after discharge, and die at 3 times the rate of the younger population. Although the high mortality rates associated with cervical spine, hip, and pelvic ring fractures were not unexpected, the injuries that were statistically associated with mortality were unexpected. Injuries such as clavicle fracture were statistically associated with mortality. As our population ages and becomes more active, the demographic may gain in clinical importance. Prognostic Level II. See Instructions for Authors for a complete description of levels of evidence.

  10. 呼吸系统疾病住院患者的人口学特征及其易患因素分析%Analysis on the Demographic Characteristics of Patients with Respiratory Diseases and Relevant Influencing Factors

    Institute of Scientific and Technical Information of China (English)

    田伟

    2015-01-01

    ,提高生命质量。%Objectives To analyze the changes in the composition of respiratory diseases,demographic characteristics of the patients as well as the influencing factors of the patients with respiratory diseases in a Three A and Tertiary Hospital from 2009 to 2013,thus provide evidence for the formulation of prevention measures by relevant departments.Methods 6000 cases of patients were extracted using the stratified proportional method.SPSS Data Entry 2.0 software was used to establish database.In the descriptive statistics the frequencies and proportions were used to describe categorical data,minimum,maximum were used to describe quantitative data.EXCEL 2007 software was used for drawing.In the inferential univariate analysis usedχ2 test and multivariate analysis used non-conditional logistic regression model.SPSS 13.0 software and SAS 9.0 software were used to analyze the data.Results In our hospital,the number of patients with respiratory diseases was the highest proportion of all patients in 2009 to 2013.Male patients with respiratory diseases accounted for 62.90% (651/1035) and women accounted for 37.20% (385/1035).Patients ranged in age from 0 to 97 years,with an average (35.77±32.95) years,of which the largest proportion aged under 5 years old,accounting for 27.05% (280/1035).Patients dominated by Han Chinese and urban populations.Career focused on children,students and retirees.Univariate analysis byχ2 test showed that the main impact factors about patients with respiratory diseases were gender,age segmentation, ethnic,regional,occupation (P values less than or equal to 0.001).Multivariate stepwise logistic regression analysis showed that the main impact factors about patients with respiratory diseases were gender (OR = 0.672),41 to 60 years (OR = 0.459),61 years and older (OR = 0.478),ethnic (OR = 0.471),region (OR = 0.256),commercial and service workers (OR = 0.449),retirees (OR = 3.025),housework and unemployed (OR = 0.410),other occupations (OR = 0.441).Conclusions The main

  11. Attitudes Toward Seeking Professional Psychological Help: Factor Structure and Socio-Demographic Predictors.

    Science.gov (United States)

    Picco, Louisa; Abdin, Edimanysah; Chong, Siow Ann; Pang, Shirlene; Shafie, Saleha; Chua, Boon Yiang; Vaingankar, Janhavi A; Ong, Lue Ping; Tay, Jenny; Subramaniam, Mythily

    2016-01-01

    Attitudes toward seeking professional psychological help (ATSPPH) are complex. Help seeking preferences are influenced by various attitudinal and socio-demographic factors and can often result in unmet needs, treatment gaps, and delays in help-seeking. The aims of the current study were to explore the factor structure of the ATSPPH short form (-SF) scale and determine whether any significant socio-demographic differences exist in terms of help-seeking attitudes. Data were extracted from a population-based survey conducted among Singapore residents aged 18-65 years. Respondents provided socio-demographic information and were administered the ATSPPH-SF. Weighted mean and standard error of the mean were calculated for continuous variables, and frequencies and percentages for categorical variables. Confirmatory factor analysis and exploratory factor analysis were performed to establish the validity of the factor structure of the ATSPPH-SF scale. Multivariable linear regressions were conducted to examine predictors of each of the ATSPPH-SF factors. The factor analysis revealed that the ATSPPH-SF formed three distinct dimensions: "Openness to seeking professional help," "Value in seeking professional help," and "Preference to cope on one's own." Multiple linear regression analyses showed that age, ethnicity, marital status, education, and income were significantly associated with the ATSPPH-SF factors. Population subgroups that were less open to or saw less value in seeking psychological help should be targeted via culturally appropriate education campaigns and tailored and supportive interventions.

  12. Attitudes towards seeking professional psychological help: Factor structure and socio-demographic predictors

    Directory of Open Access Journals (Sweden)

    Louisa ePicco

    2016-04-01

    Full Text Available Attitudes toward seeking professional psychological help (ATSPPH are complex. Help seeking preferences are influenced by various attitudinal and socio-demographic factors and can often result in unmet needs, treatment gaps and delays in help seeking. The aims of the current study were to explore the factor structure of the ATSPPH short form (-SF scale and determine whether any significant socio-demographic differences exist in terms of help-seeking attitudes. Data were extracted from a population-based survey conducted among Singapore residents aged 18-65 years. Respondents provided socio-demographic information and were administered the ATSPPH-SF. Weighted mean and standard error of the mean were calculated for continuous variables, and frequencies and percentages for categorical variables. Confirmatory factor analysis and exploratory factor analysis were performed to establish the validity of the factor structure of the ATSPPH-SF scale. Multivariable linear regressions were conducted to examine predictors of each of the ATSPPH-SF factors. The factor analysis revealed that the ATSPPH-SF formed three distinct dimensions: ‘Openness to seeking professional help’, ‘Value in seeking professional help’ and ‘Preference to cope on one’s own’. Multiple linear regression analyses showed that age, gender, ethnicity, marital status, education, and employment status were significantly associated with the ATSPPH-SF factors. Population subgroups that were less open to or saw less value in seeking psychological help should be targeted via culturally appropriate education campaigns and tailored and supportive interventions.

  13. CONSEQUENCES OF THE DEMOGRAPHIC CRISIS

    Directory of Open Access Journals (Sweden)

    LIVIU RADU

    2014-11-01

    Full Text Available Major dysfunctionalities can arise from the demographic decline, both on a social level and from the perspective of the economic-financial evolution of the world’s states. The obvious aging of the industrialized states’ population overlapping the import of cheap workforce in the developing countries can start mutations whose consequences are somewhat predictable but discouraging. An accelerated urbanization of the states is foreseen, as well as the decrease of birthrates, negative external migration, increase of mortality and its stagnation in a larger value than that of the birthrate, and not least the population’s aging will hinder a part of the developing countries to sustain a high rhythm of long-term economical increase. The socialeconomic consequences will be reflected in the labor market, the householders’ amount of income as well as in the education’s level. All of these aspects call for a rethinking of the public politics, especially of the social insurance’s system and of the education, a reorientation of the economy based on the increase of specializing in production and productivity, as well as a financial stability unburdened by the politics’ interference in the business environment.

  14. Analysis correlation between social-demographic characteristics and nurse-patient communication competence of clinical nursing students%临床实习护生社会人口学特征与护患沟通能力的相关性分析

    Institute of Scientific and Technical Information of China (English)

    林陶玉

    2016-01-01

    Objective To investigate and analyze the relationship between social-demographic characteristics and nurse-patient communication competence of clinical nursing students. Methods The questionnaire of social-demo-graphic characteristics and the evaluation of nurse-patient communication competence of nursing students were conducted among 135 nursing students. Results Age, education and family background of nursing students were significantly posi-tively correlated with their ability of nurse-patient communication ( P<0. 05 ) , while gender and nationality were signifi-cantly negatively correlated with their alility of nurse-patient communication ( P<0. 05 ) . Linear regression analysis showed that age, education, family atmosphere, gender and nationality entered the linear regression equation, which indicated the five variables were of significant for prediction ( P<0. 05 ) . Conclusions Social-demographic character-istics of clinical nursing students were closely realted to nurse-patient communication competence. Target nurse-patient communication training should be provided according to different social-demographic characteristics of nursing students, to improve the ability of nurse-patient communication.%目的 调查分析临床实习护生的社会人口学特征与护患沟通能力的关系. 方法 采用护生社会人口学特征调查表和护理专业护生护患沟通能力评价量表,对135名临床实习护生进行问卷调查. 结果 临床实习护生的年龄、学历和家庭氛围与其护患沟通能力呈正相关( P<0. 05 );而性别、民族与其护患沟通能力呈负相关( P<0. 05 ). 线性回归分析显示:年龄、学历、家庭氛围、性别和民族进入护患沟通能力总分的线性回归方程,表明5个变量对护生护患沟通能力有显著的预测作用( P<0. 05 ). 结论 临床实习护生的社会人口学特征与护患沟通能力密切相关,应根据护生的不同社会人口学特征进行针对性护患沟通

  15. Demographic changes and international factor mobility

    OpenAIRE

    2004-01-01

    This paper reviews the extent and policy implications of linkages between demographic changes and international factor mobility. Evidence is found of significant demographic effects on both migration and the current account, but for different reasons neither increased migration nor international transfers of savings is expected to offer much assistance in digesting the variety of demographic transitions expected over the next fifty years. The paper also examines more briefly the effects of de...

  16. Disc distraction shows evidence of regenerative potential in degenerated intervertebral discs as evaluated by protein expression, magnetic resonance imaging, and messenger ribonucleic acid expression analysis.

    Science.gov (United States)

    Guehring, Thorsten; Omlor, Georg W; Lorenz, Helga; Engelleiter, Karl; Richter, Wiltrud; Carstens, Claus; Kroeber, Markus

    2006-07-01

    An animal model of degeneration was used to determine the effects of disc distraction, and was evaluated with magnetic resonance imaging (MRI) as well as gene and protein expression levels. To investigate gene expression and MRI effects of distraction. Disc degeneration can result from hyper-physiologic loading. Distracted discs with degeneration showed histologic signs of tissue recovery. There were 18 rabbits that underwent 28 days of compression (200 N) to induce moderate disc degeneration followed by 28 days of distraction (120 N; attached and loaded distraction device) or sham distraction (attached but unloaded distraction device). Comparison was performed with 56 days of compressed discs without distraction. Quantitative outcome measures were MRI signal intensity and gene expression analysis to determine: messenger ribonucleic acid levels for extracellular matrix genes, including collagen 1, collagen 2, biglycan, decorin, aggrecan, fibromodulin, and osteonectin; and matrix-regulative genes, including matrix metalloproteinase-13, tissue-inhibitor of matrix metalloproteinase-1, and bone morphogenetic protein (BMP)-2. Immunohistology was performed for collagen 2 and BMP-2 to label cells semiquantitatively by staining of the cell-surrounding matrix. A total of 28 days of compression decreased signal intensity. Distraction over the same period reestablished physiologic signal intensity, however, a persistent reduction was found in sham distraction. Distraction resulted in gene expression up-regulation of collagen 1 (5.4-fold), collagen 2 (5.5-fold), biglycan (7.7-fold), and decorin (3.4-fold), while expression of fibromodulin (0.16-fold), tissue-inhibitor of matrix metalloproteinase-1 (0.05-fold), and BMP-2 (0.15-fold) was decreased, as compared with 56 days compression. Distracted discs showed more BMP-2 (19.67 vs. 3.67 in 56 days compression) and collagen 2 (18.67 vs. 11.33 in 56 days compression) positive cells per field. Distraction results in disc rehydration

  17. Genome-wide analysis of AP2/ERF family genes from Lotus corniculatus shows LcERF054 enhances salt tolerance.

    Science.gov (United States)

    Sun, Zhan-Min; Zhou, Mei-Liang; Xiao, Xing-Guo; Tang, Yi-Xiong; Wu, Yan-Min

    2014-09-01

    Lotus corniculatus is used in agriculture as a main forage plant. Members of the Apetala2/ethylene response factor (AP2/ERF) family play important roles in regulating gene expression in response to many forms of stress, including drought and salt. Here, starting from database of the L. corniculatus var. japonicus genome, we identified 127 AP2/ERF genes by insilico cloning method. The phylogeny, gene structures, and putative conserved motifs in L. corniculatus var. japonicus ERF proteins were analyzed. Based on the number of AP2/ERF domains and the function of the genes, 127 AP2/ERF genes from L. corniculatus var. japonicus were classified into five subfamilies named the AP2, dehydration-responsive element binding factor (DREB), ERF, RAV, and a soloist. Outside the AP2/ERF domain, many L. corniculatus var. japonicus-specific conserved motifs were detected. Expression profile analysis of AP2/ERF genes by quantitative real-time PCR revealed that 19 LcERF genes, including LcERF054 (KJ004728), were significantly induced by salt stress. The results showed that the LcERF054 gene encodes a nuclear transcription activator. Overexpression of LcERF054 in Arabidopsis enhanced the tolerances to salt stress, showed higher germination ratio of seeds, and had elevated levels of relative moisture contents, soluble sugars, proline, and lower levels of malondialdehyde under stress conditions compared to wild-type plants. The expression of hyperosmotic salinity response genes COR15A, LEA4-5, P5CS1, and RD29A was found to be elevated in the LcERF054-overexpressing Arabidopsis plants compared to wild type. These results revealed that the LcERF genes play important roles in L. corniculatus cv Leo under salt stress and that LcERFs are attractive engineering targets in applied efforts to improve abiotic stress tolerances in L. corniculatus cv Leo or other crops.

  18. Leisure Lifestyles: Segmentation by Interests, Needs, Demographics, and Television Viewing.

    Science.gov (United States)

    Greenberg, Marshall G.; Frank, Ronald E.

    1983-01-01

    Using their own 1978 national survey sample, the authors describe the social and demographic characteristics, psychological needs, and television viewing behaviors of persons who exhibit each of 14 patterns of leisure activities. The patterns were isolated through factor analysis and clustering techniques. (Author/RM)

  19. Economic and Demographic Factors Impacting Placement of Students with Autism

    Science.gov (United States)

    Kurth, Jennifer A.; Mastergeorge, Ann M.; Paschall, Katherine

    2016-01-01

    Educational placement of students with autism is often associated with child factors, such as IQ and communication skills. However, variability in placement patterns across states suggests that other factors are at play. This study used hierarchical cluster analysis techniques to identify demographic, economic, and educational covariates…

  20. Relationship between Selected Socio-Demographic Factors and Cancer of Oral Cavity - A Case Control Study.

    Science.gov (United States)

    Madani, Abdoul Hossain; Dikshit, Madhurima; Bhaduri, Debanshu; Jahromi, Abdolreza Sotoodeh; Aghamolaei, Teamur

    2010-08-11

    The aim of this study was to recognize factors associated with cancer of oral cavity considering socio-demographic characteristics. The cases were 350 with squamous-cell carcinoma of oral cavity diagnosed between 2005 and 2006 in Morbai, Narandia, Budharani Cancer Institute, Pune, India. Similar number of controls match for age and sex selected from the background population. Cases and controls were interviewed for tobacco related habits and general characteristics; age, gender, education and possible socio-demographic factors. Chi-square test in uni-variate analysis and estimate for risk showed that education, occupation and monthly household income were significantly different between cases and controls (P currency (OR = 1.7, CI 1.2-2.3) were significant risk factors for oral cancer. While, there was no significant relationship between religious and or marital status either in males or females.

  1. Contrasting demographic histories of the neighboring bonobo and chimpanzee

    DEFF Research Database (Denmark)

    Hvilsom, Christina; Carlsen, Frands; Heller, Rasmus

    2014-01-01

    analyzed complete mitochondrial genomes representing all four recognized chimpanzee subspecies and the bonobo to infer the recent demographic history and used simulations to exclude a confounding effect of population structure. Our genus-wide Bayesian coalescent-based analysis revealed surprisingly...... dissimilar demographic histories of the chimpanzee subspecies and the bonobo, despite their overlapping habitat requirements. Whereas the central and eastern chimpanzee subspecies were inferred to have expanded tenfold between around 50,000 and 80,000 years ago and today, the population size...

  2. Genome-wide transcriptional analysis of Drosophila larvae infected by entomopathogenic nematodes shows involvement of complement, recognition and extracellular matrix proteins.

    Science.gov (United States)

    Arefin, Badrul; Kucerova, Lucie; Dobes, Pavel; Markus, Robert; Strnad, Hynek; Wang, Zhi; Hyrsl, Pavel; Zurovec, Michal; Theopold, Ulrich

    2014-01-01

    Heterorhabditis bacteriophora is an entomopathogenic nematode (EPN) which infects its host by accessing the hemolymph where it releases endosymbiotic bacteria of the species Photorhabdus luminescens. We performed a genome-wide transcriptional analysis of the Drosophila response to EPN infection at the time point at which the nematodes reached the hemolymph either via the cuticle or the gut and the bacteria had started to multiply. Many of the most strongly induced genes have been implicated in immune responses in other infection models. Mapping of the complete set of differentially regulated genes showed the hallmarks of a wound response, but also identified a large fraction of EPN-specific transcripts. Several genes identified by transcriptome profiling or their homologues play protective roles during nematode infections. Genes that positively contribute to controlling nematobacterial infections encode: a homolog of thioester-containing complement protein 3, a basement membrane component (glutactin), a recognition protein (GNBP-like 3) and possibly several small peptides. Of note is that several of these genes have not previously been implicated in immune responses.

  3. Molecular analysis of a case of nevus of ota showing progressive evolution to melanoma with intermediate stages resembling cellular blue nevus.

    Science.gov (United States)

    Gerami, Pedram; Pouryazdanparast, Pedram; Vemula, Swapna; Bastian, Boris C

    2010-05-01

    Nevus of Ota is a variant of congenital nevus, which is morphologically paucicellular and resembles a common blue nevus. Although nevus of Ota is a risk factor for uveal melanoma in white people, the development of cutaneous melanoma within nevus of Ota is a very rare occurrence with only a few reported cases. We present a case of a long-standing nevus of Ota, with radiologic imaging demonstrating a large retro-orbital mass and a biopsy showing melanoma. The histopathology of the eye exenteration specimen illustrated various stages of melanocytic progression including areas resembling a nevus of Ota, blue nevus, cellular blue nevus, and melanoma. There was heterogeneity in the overtly malignant sections with some areas displaying expansile nodules of blander appearing spindled cells, whereas other areas were composed of epithelioid cells with higher mitotic counts and zones of necrosis. The extensive lesion also infiltrated the soft tissue and bone. We performed gene mutation analysis for GNAQ, BRAF, NRAS, and KIT and fluorescence in situ hybridization (FISH) targeting commonly altered chromosomal loci in melanoma and comparative genomic hybridization (CGH). Copy number changes typical of melanoma were identified by both FISH and CGH in the morphologically malignant areas illustrating the relationship of tumor progression and the progressive acquisition of genetic aberrations.

  4. The Health Show

    OpenAIRE

    Swann, David

    2011-01-01

    Dr David Swann interviewed on The Health Show, Series 1, Episode 5, 2011 for BBC World about the award-winning 21st Century Nursing Bag. BBC World News reaches 241million people every week, available in 296 million homes, 1.8 million hotel rooms and has the highest average viewership on a weekday of any international news channel. The Health Show is a new 26-part series for BBC World News covering the most important news stories from around the world.

  5. Socio-economic factors and use of maternal health services are associated with delayed initiation and non-exclusive breastfeeding in Indonesia: secondary analysis of Indonesia Demographic and Health Surveys 2002/2003 and 2007.

    Science.gov (United States)

    Titaley, Christiana R; Loh, Philips C; Prasetyo, Sabarinah; Ariawan, Iwan; Shankar, Anuraj H

    2014-01-01

    This analysis aims to examine factors associated with delayed initiation and non-exclusive breastfeeding in Indonesia. Data were derived from the 2002/2003 and 2007 Indonesia Demographic and Health Survey. Information from 12,191 singleton live-born infants aged 0-23 months was used to examine factors associated with delayed initiation of breastfeeding. Furthermore, information from 3,187 singleton live-born infants aged 0-5 months was used to identify factors associated with non-exclusive breastfeeding. Associations between potential predictors and study outcomes were examined using logistic regression. Our study found that infants from high household wealth-index had significantly increased odds of both delayed initiation and non-exclusive breastfeeding. Other factors associated with an increased odds of delayed initiation of breastfeeding included infants from Sumatera region (OR=1.64, 95% CI: 1.38-1.95), Caesarean-section deliveries (OR=1.84, 95% CI: 1.39-2.44) and deliveries in government-owned (OR=1.38, 95% CI: 1.08-1.76) and non-health facility (OR=1.20, 95% CI: 1.00-1.43). Other factors associated with an increased odds for non-exclusive breastfeeding included parents who were in the workforce (OR=1.37, 95% CI: 1.06-1.78) and mothers with obstetric complication at childbirth (OR=1.35, 95% CI: 1.05-1.74). However, the odds reduced for infants from Eastern Indonesia (OR=0.64, 95% CI: 0.49-0.85). Poor breastfeeding practices are associated with environmental, socio-economic, pregnancy-birthing characteristics and maternal health services factors. Efforts to promote breastfeeding practices should be conducted comprehensively to target population at risk for poor breastfeeding practices.

  6. A Fashion Show

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    <正>Story: The yearly fashion show day.The children take turns to walk on the stage and show the class their favorite clothes.Now it’s Joe’s and Phoebe’s turn.Joe walks on the stage and says,“My shorts are blue.Do you like my blue shorts?”On the other side of the stage, Phoebe is wearing her favorite pink skirt.“My skirt is pink.Do you like my pink skirt?”asks

  7. Characterization and Genetic Analysis of a Novel Light-Dependent Lesion Mimic Mutant, lm3, Showing Adult-Plant Resistance to Powdery Mildew in Common Wheat.

    Directory of Open Access Journals (Sweden)

    Fang Wang

    Full Text Available Lesion mimics (LMs that exhibit spontaneous disease-like lesions in the absence of pathogen attack might confer enhanced plant disease resistance to a wide range of pathogens. The LM mutant, lm3 was derived from a single naturally mutated individual in the F1 population of a 3-1/Jing411 cross, backcrossed six times with 3-1 as the recurrent parent and subsequently self-pollinated twice. The leaves of young seedlings of the lm3 mutant exhibited small, discrete white lesions under natural field conditions. The lesions first appeared at the leaf tips and subsequently expanded throughout the entire leaf blade to the leaf sheath. The lesions were initiated through light intensity and day length. Histochemical staining revealed that lesion formation might reflect programmed cell death (PCD and abnormal accumulation of reactive oxygen species (ROS. The chlorophyll content in the mutant was significantly lower than that in wildtype, and the ratio of chlorophyll a/b was increased significantly in the mutant compared with wildtype, indicating that lm3 showed impairment of the biosynthesis or degradation of chlorophyll, and that Chlorophyll b was prone to damage during lesion formation. The lm3 mutant exhibited enhanced resistance to wheat powdery mildew fungus (Blumeria graminis f. sp. tritici; Bgt infection, which was consistent with the increased expression of seven pathogenesis-related (PR and two wheat chemically induced (WCI genes involved in the defense-related reaction. Genetic analysis showed that the mutation was controlled through a single partially dominant gene, which was closely linked to Xbarc203 on chromosome 3BL; this gene was delimited to a 40 Mb region between SSR3B450.37 and SSR3B492.6 using a large derived segregating population and the available Chinese Spring chromosome 3B genome sequence. Taken together, our results provide information regarding the identification of a novel wheat LM gene, which will facilitate the additional fine

  8. Structural analysis of the alcohol acyltransferase protein family from Cucumis melo shows that enzyme activity depends on an essential solvent channel.

    Science.gov (United States)

    Galaz, Sebastián; Morales-Quintana, Luis; Moya-León, María Alejandra; Herrera, Raúl

    2013-03-01

    Alcohol acyltransferases (AAT) play a key role in ester biosynthesis. In Cucumis melo var. cantalupensis, AATs are encoded by a gene family of four members (CmAAT1-4). CmAAT1, CmAAT3 and CmAAT4 are capable of synthesizing esters, with CmAAT1 the most active. CmAAT2 is inactive and has an Ala268 residue instead of a threonine which is present in all other active AATs, although the role of this residue is still unclear. The present work aims to understand the molecular mechanism involved in ester biosynthesis in melon fruit and to clarify the importance of the Ala268 residue. First, structural models for each protein were built by comparative modelling methodology. Afterwards, conformational interaction between the protein and several ligands, alcohols and acyl-CoAs was explored by molecular docking and molecular dynamics simulation. Structural analysis showed that CmAATs share a similar structure. Also, well-defined solvent channels were described in the CmAATs except for CmAAT2 which does not have a proper channel and instead has a small pocket around Ala268. Residues of the catalytic HxxxD motif interact with substrates within the solvent channel, with Ser363 also important. Strong binding interaction energies were described for the best substrate couple of each CmAAT (hexyl-, benzyl- and cinnamyl-acetate for CmAAT1, 3 and 4 respectively). CmAAT1 and CmAAT2 protein surfaces share similar electrostatic potentials; nevertheless the entrance channels for the substrates differ in location and electrostatic character, suggesting that Ala268 might be responsible for that. This could partly explain the major differences in activity reported for these two enzymes.

  9. Transcriptomic analysis of the interaction between Helianthus annuus and its obligate parasite Plasmopara halstedii shows single nucleotide polymorphisms in CRN sequences

    Directory of Open Access Journals (Sweden)

    Gouzy Jérôme

    2011-10-01

    Full Text Available Abstract Background Downy mildew in sunflowers (Helianthus annuus L. is caused by the oomycete Plasmopara halstedii (Farl. Berlese et de Toni. Despite efforts by the international community to breed mildew-resistant varieties, downy mildew remains a major threat to the sunflower crop. Very few genomic, genetic and molecular resources are currently available to study this pathogen. Using a 454 sequencing method, expressed sequence tags (EST during the interaction between H. annuus and P. halstedii have been generated and a search was performed for sites in putative effectors to show polymorphisms between the different races of P. halstedii. Results A 454 pyrosequencing run of two infected sunflower samples (inbred lines XRQ and PSC8 infected with race 710 of P. halstedii, which exhibit incompatible and compatible interactions, respectively generated 113,720 and 172,107 useable reads. From these reads, 44,948 contigs and singletons have been produced. A bioinformatic portal, HP, was specifically created for in-depth analysis of these clusters. Using in silico filtering, 405 clusters were defined as being specific to oomycetes, and 172 were defined as non-specific oomycete clusters. A subset of these two categories was checked using PCR amplification, and 86% of the tested clusters were validated. Twenty putative RXLR and CRN effectors were detected using PSI-BLAST. Using corresponding sequences from four races (100, 304, 703 and 710, 22 SNPs were detected, providing new information on pathogen polymorphisms. Conclusions This study identified a large number of genes that are expressed during H. annuus/P. halstedii compatible or incompatible interactions. It also reveals, for the first time, that an infection mechanism exists in P. halstedii similar to that in other oomycetes associated with the presence of putative RXLR and CRN effectors. SNPs discovered in CRN effector sequences were used to determine the genetic distances between the four races

  10. Predicting tobacco sales in community pharmacies using population demographics and pharmacy type.

    Science.gov (United States)

    Hickey, Lisa M; Farris, Karen B; Peterson, N Andrew; Aquilino, Mary L

    2006-01-01

    To determine whether the population demographics of the location of pharmacies were associated with tobacco sales in pharmacies, when controlling for pharmacy type. Retrospective analysis. Iowa. All retailers in Iowa that obtained tobacco licenses and all pharmacies registered with the Iowa Board of Pharmacy in 2003. MAIN OUTCOME MEASURE AND INTERVENTIONS: Percentage of pharmacies selling tobacco (examined by pharmacy type using chi-square analysis); median income and distribution of race/ethnicity in the county for pharmacies that did or did not sell tobacco (t tests); predictors of whether a pharmacy sold tobacco (logistic regression using the independent variables county-level demographic variables and pharmacy characteristics). County gender composition, race/ethnicity make-up, and income levels were different for tobacco-selling and -nonselling pharmacies. Logistic regression showed that whether a pharmacy sold tobacco was strongly dependent on the type of pharmacy; compared with independent pharmacies (of which only 5% sold tobacco products), chain pharmacies were 34 times more likely to sell tobacco products, mass merchandiser outlets were 47 times more likely to stock these goods, and grocery stores were 378 times more likely to do so. Pharmacies selling tobacco were more likely to be located in counties with significantly higher numbers of multiracial groups. The best predictor of whether an Iowa pharmacy sells tobacco products is type of pharmacy. In multivariable analyses, population demographics of the county in which pharmacies were located were generally not predictive of whether a pharmacy sold tobacco.

  11. On not showing scalps

    DEFF Research Database (Denmark)

    Marselis, Randi Lorenz

    2016-01-01

    proposed by Janet Marstine, the editor of the Routledge Companion to Museum Ethics, I show how the museum succeeded in engaging users in questions of museum ethics. However, this specific debate on human remains in museums developed into an encounter between a global, museological discourse...

  12. Violence and TV Shows

    OpenAIRE

    ÖZTÜRK, Yrd. Doç. Dr. Şinasi

    2008-01-01

    This study aims to discuss theories on theviolent effects of TV shows on viewers, especiallyon children. Therefore, this study includes a briefdiscussion of definitions of violence, discussionof violence theories, main results of researcheson televised violence, measuring TV violence,perception of televised violence, individualdifferences and reactions to TV violence,aggressiveness and preferences for TV violence.

  13. Honored Teacher Shows Commitment.

    Science.gov (United States)

    Ratte, Kathy

    1987-01-01

    Part of the acceptance speech of the 1985 National Council for the Social Studies Teacher of the Year, this article describes the censorship experience of this honored social studies teacher. The incident involved the showing of a videotape version of the feature film entitled "The Seduction of Joe Tynan." (JDH)

  14. A Visionary Show

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    Seduction. Distinction. Relax. Pulsation. These are the "style universes" on display at Première Vision, heralded as "The World’s Premiere Fabric Show." Started more than 35 years ago by 15 French weavers, Première Vision has expanded beyond its

  15. Honored Teacher Shows Commitment.

    Science.gov (United States)

    Ratte, Kathy

    1987-01-01

    Part of the acceptance speech of the 1985 National Council for the Social Studies Teacher of the Year, this article describes the censorship experience of this honored social studies teacher. The incident involved the showing of a videotape version of the feature film entitled "The Seduction of Joe Tynan." (JDH)

  16. Asian/Pacific Islander Librarians Career Choices: Demographics and Descriptive Analysis 美國亞太裔圖書館員的職業選擇:人口統計特徵和描述性分析

    Directory of Open Access Journals (Sweden)

    周堅中、周格蘭、周陽蘭、周米蘭 Jianzhong Zhou, Glen Zhou, Allan Zhou, Milan Zhou

    2013-09-01

    Full Text Available The study first reviews the history of Asian immigrants since 1850s and the significance of the Immigration and Nationality Act of 1965 on current Asian Americans/Pacific Islanders (AAPI population and demographics in the United States. Then the study summarizes previous research of AAPI librarians and conducts a new survey to inquire the status of AAPI librarians. From 91 completed surveys out of over 600 distributed, the study shows a demographic picture of AAPI librarians and lists factors associated with AAPI librarians’ career choices. In addition, the study compares United States immigration and international student data with MLS conferred by race/ethnicity data in order to predict the future growth of AAPI librarians. The analyses of both data sources show that more international students from Asia are studying in the United States and becoming the United States citizens and residents, but fewer international students and Asian American students, compared with other race/ethnic groups, choose librarianship as a career. At the end, the study predicts the future growth of AAPI librarians will be slower compared to other minority groups, and the percentage of AAPI librarians among total credentialed librarians will become lower. pp. 111-129本文首先回顧自19 世紀50 年代美國亞洲移民的歷史和分析當前美國亞裔/太平洋島民(AAPI)的人口統計。強調美國1965 年的新移民和國籍法案對美國亞太裔人口增長及職業選擇的意義。其次,本文在總結以前有關亞太裔館員的研究之基礎上,對目前亞太裔圖書館員的職業狀態設計和開展全新的電子問卷調查研究。在選取的600 多名亞太裔圖書館員中,91 人完成了職業狀態調查。由此考察和分析美國亞太裔圖書館員職業特徵與影響亞太裔圖書館員職業選擇的相關因素。最後,本文比較1999-2010 年美國亞洲移民和來美的亞洲國際學生與美國

  17. Bias and ignorance in demographic perception.

    Science.gov (United States)

    Landy, D; Guay, B; Marghetis, T

    2017-08-31

    When it comes to knowledge of demographic facts, misinformation appears to be the norm. Americans massively overestimate the proportions of their fellow citizens who are immigrants, Muslim, LGBTQ, and Latino, but underestimate those who are White or Christian. Previous explanations of these estimation errors have invoked topic-specific mechanisms such as xenophobia or media bias. We reconsidered this pattern of errors in the light of more than 30 years of research on the psychological processes involved in proportion estimation and decision-making under uncertainty. In two publicly available datasets featuring demographic estimates from 14 countries, we found that proportion estimates of national demographics correspond closely to what is found in laboratory studies of quantitative estimates more generally. Biases in demographic estimation, therefore, are part of a very general pattern of human psychology-independent of the particular topic or demographic under consideration-that explains most of the error in estimates of the size of politically salient populations. By situating demographic estimates within a broader understanding of general quantity estimation, these results demand reevaluation of both topic-specific misinformation about demographic facts and topic-specific explanations of demographic ignorance, such as media bias and xenophobia.

  18. The State Economic, Demographic & Fiscal Handbook 1993.

    Science.gov (United States)

    Baer, David; Cohen, Lee

    This handbook is an easy-to-use reference book for policymakers, public officials, and policy analysts, as well as anyone else who may need up-to-date information about state economic, demographic, and fiscal data. The book includes data on demographics, poverty rates, per capita state personal income, state and local tax rates, and state and…

  19. 5 CFR 841.404 - Demographic factors.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Demographic factors. 841.404 Section 841... (CONTINUED) FEDERAL EMPLOYEES RETIREMENT SYSTEM-GENERAL ADMINISTRATION Government Costs § 841.404 Demographic factors. (a) The Office of Personnel Management (OPM) will consider the factors listed below...

  20. Demographic and clinical features of neuromyelitis optica

    DEFF Research Database (Denmark)

    Pandit, L.; Asgari, Nasrin; Apiwattanakul, M.

    2015-01-01

    The comparative clinical and demographic features of neuromyelitis optica (NMO) are not well known. In this review we analyzed peer-reviewed publications for incidence and prevalence, clinical phenotypes, and demographic features of NMO. Population-based studies from Europe, South East and Southe...

  1. Motivating the population to cope with the demographic change

    OpenAIRE

    König, Armin

    2009-01-01

    The effects of the demographic challenge will change the nature of politics and the emphasis of political sectors over the next 20 years, especially on a local level. This calls for new ways of thinking, new social skills and a new frame of awareness to allow for sustainable development. The community of Illingen in the Saarland, a town of 18,000 residents, has not denied the demographic change, but has accepted it. It shows how the populace, politics and administration have been confronted w...

  2. Demographic and labor market in the Chilean countryside Transformations

    Directory of Open Access Journals (Sweden)

    Carlos René Rodríguez Garcés

    2016-12-01

    Full Text Available Based on the information provided by the National Socioeconomic Survey of 1990 and 2013, the Chilean countryside reconfigurations are analyzed in terms of their demographic trends and labor market restructuring. A continuous process of depopulation and aging of the rural population is demographically notes. The agricultural activities of the rural labor market charge less important in terms of jobs and income, showing a strong process and favoring deagrarianisation positioning services area. Finally, a growing number of households that hold informal consensual unions and a greater presence of single-parent households, mainly consisting of female-headed households is observed.

  3. Fast demographic traits promote high diversification rates of Amazonian trees

    NARCIS (Netherlands)

    Baker, Timothy R; Pennington, R Toby; Magallon, Susana; Gloor, Emanuel; Laurance, William F; Alexiades, Miguel; Alvarez, Esteban; Araujo, Alejandro; Arets, Eric J M M; Aymard, Gerardo; de Oliveira, Atila Alves; Amaral, Iêda; Arroyo, Luzmila; Bonal, Damien; Brienen, Roel J W; Chave, Jerome; Dexter, Kyle G; Di Fiore, Anthony; Eler, Eduardo; Feldpausch, Ted R; Ferreira, Leandro; Lopez-Gonzalez, Gabriela; van der Heijden, Geertje; Higuchi, Niro; Honorio, Eurídice; Huamantupa, Isau; Killeen, Tim J; Laurance, Susan; Leaño, Claudio; Lewis, Simon L; Malhi, Yadvinder; Marimon, Beatriz Schwantes; Marimon Junior, Ben Hur; Monteagudo Mendoza, Abel; Neill, David; Peñuela-Mora, Maria Cristina; Pitman, Nigel; Prieto, Adriana; Quesada, Carlos A; Ramírez, Fredy; Ramírez Angulo, Hirma; Rudas, Agustin; Ruschel, Ademir R; Salomão, Rafael P; de Andrade, Ana Segalin; Silva, J Natalino M; Silveira, Marcos; Simon, Marcelo F; Spironello, Wilson; ter Steege, Hans|info:eu-repo/dai/nl/075217120; Terborgh, John; Toledo, Marisol; Torres-Lezama, Armando; Vasquez, Rodolfo; Vieira, Ima Célia Guimarães; Vilanova, Emilio; Vos, Vincent A; Phillips, Oliver L; Santos, F.

    2014-01-01

    The Amazon rain forest sustains the world's highest tree diversity, but it remains unclear why some clades of trees are hyperdiverse, whereas others are not. Using dated phylogenies, estimates of current species richness and trait and demographic data from a large network of forest plots, we show

  4. Demographic Correlates and Factor Structure of the Family Environment Scale.

    Science.gov (United States)

    Boake, Corwin; Salmon, Paul G.

    1983-01-01

    Factor analyzed the Family Environment Scale (FES) subscale scores of 204 families and correlated them with family demographic characteristics. The obtained factor structure showed two major factors similar to "control" and "acceptance-rejection" dimensions in previous research. Results support the FES as part of multimethod…

  5. Fast demographic traits promote high diversification rates of Amazonian trees

    NARCIS (Netherlands)

    Baker, Timothy R; Pennington, R Toby; Magallon, Susana; Gloor, Emanuel; Laurance, William F; Alexiades, Miguel; Alvarez, Esteban; Araujo, Alejandro; Arets, Eric J M M; Aymard, Gerardo; de Oliveira, Atila Alves; Amaral, Iêda; Arroyo, Luzmila; Bonal, Damien; Brienen, Roel J W; Chave, Jerome; Dexter, Kyle G; Di Fiore, Anthony; Eler, Eduardo; Feldpausch, Ted R; Ferreira, Leandro; Lopez-Gonzalez, Gabriela; van der Heijden, Geertje; Higuchi, Niro; Honorio, Eurídice; Huamantupa, Isau; Killeen, Tim J; Laurance, Susan; Leaño, Claudio; Lewis, Simon L; Malhi, Yadvinder; Marimon, Beatriz Schwantes; Marimon Junior, Ben Hur; Monteagudo Mendoza, Abel; Neill, David; Peñuela-Mora, Maria Cristina; Pitman, Nigel; Prieto, Adriana; Quesada, Carlos A; Ramírez, Fredy; Ramírez Angulo, Hirma; Rudas, Agustin; Ruschel, Ademir R; Salomão, Rafael P; de Andrade, Ana Segalin; Silva, J Natalino M; Silveira, Marcos; Simon, Marcelo F; Spironello, Wilson; ter Steege, Hans; Terborgh, John; Toledo, Marisol; Torres-Lezama, Armando; Vasquez, Rodolfo; Vieira, Ima Célia Guimarães; Vilanova, Emilio; Vos, Vincent A; Phillips, Oliver L; Santos, F.

    2014-01-01

    The Amazon rain forest sustains the world's highest tree diversity, but it remains unclear why some clades of trees are hyperdiverse, whereas others are not. Using dated phylogenies, estimates of current species richness and trait and demographic data from a large network of forest plots, we show th

  6. Shanghai Shows Its Heart

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    The city known as China’s economic powerhouse showed a more caring face as host of the Special Olympic Games Between October 2 and 11,the Special Olympics Summer Games were hosted in Shanghai,the first time the 40-year-old athletic com- petition for people with intellectual disabilities came to a developing country. This Special Olympics was also larger than all previous games in temps of the number of athletes.

  7. Socio-Demographic Factors, Social Support, Quality of Life, and HIV/AIDS in Ghana.

    Science.gov (United States)

    Abrefa-Gyan, Tina; Cornelius, Llewellyn J; Okundaye, Joshua

    2016-01-01

    The increase in the access to biomedical interventions for people living with HIV/AIDS in the developing world has not been adequately matched with the requisite psychosocial treatments to help improve the effectiveness of biomedical interventions. Therefore, in this study the author seeks to determine whether socio-demographic characteristics and social support are associated with quality of life in individuals diagnosed with HIV/AIDS in Ghana. A convenience sample of 300 HIV/AIDS support group members was obtained via cross-sectional design survey. The Medical Outcome Studies (MOS) HIV Health Survey, the MOS Social Support Survey (MOS-SSS), and demographic questionnaire instruments were used to assess quality of life, social support, and demographic information respectively. Multiple regression analysis showed that there was a positive association between overall social support and overall quality of life (r = .51). It also showed that being younger, male, attending support group meetings for over a year, and having ≥ 13 years of schooling related to higher quality of life. Implications of the findings for practice, policy, and research in Ghana and the rest of the developing world are discussed.

  8. The importance of socio-demographic indicators in regional disparities in turkey, 1990-1994

    OpenAIRE

    Gedik, Ayse; Sahin, Nihan; Suer, Sibel

    2002-01-01

    The aim of this study is to test the relative importance of the socio-demographic versus economic variables in discriminating the inter-regional differences in Turkey in 1990-94. Our findings show that the "socio-demographic" variables are much more significant than the "economic" variables. Among the socio-demographic variables, especially those variables related with the fertility and the size of household, and the female education such as the "female literacy ratio" and "female schooling r...

  9. Not a "reality" show.

    Science.gov (United States)

    Wrong, Terence; Baumgart, Erica

    2013-01-01

    The authors of the preceding articles raise legitimate questions about patient and staff rights and the unintended consequences of allowing ABC News to film inside teaching hospitals. We explain why we regard their fears as baseless and not supported by what we heard from individuals portrayed in the filming, our decade-long experience making medical documentaries, and the full un-aired context of the scenes shown in the broadcast. The authors don't and can't know what conversations we had, what documents we reviewed, and what protections we put in place in each televised scene. Finally, we hope to correct several misleading examples cited by the authors as well as their offhand mischaracterization of our program as a "reality" show.

  10. Climatic conditions produce contrasting influences on demographic traits in a long-distance Arctic migrant.

    Science.gov (United States)

    Cleasby, Ian R; Bodey, Thomas W; Vigfusdottir, Freydis; McDonald, Jenni L; McElwaine, Graham; Mackie, Kerry; Colhoun, Kendrew; Bearhop, Stuart

    2017-03-01

    The manner in which patterns of variation and interactions among demographic rates contribute to population growth rate (λ) is key to understanding how animal populations will respond to changing climatic conditions. Migratory species are likely to be particularly sensitive to climatic conditions as they experience a range of different environments throughout their annual cycle. However, few studies have provided fully integrated demographic analyses of migratory populations in response to changing climatic conditions. Here, we employed integrated population models to demonstrate that the environmental conditions experienced during a short but critical period play a central role in the demography of a long-distance migrant, the light-bellied Brent goose (Branta bernicla hrota). Female survival was positively associated with June North Atlantic Oscillation (NAO) values, whereas male survival was not. In contrast, breeding productivity was negatively associated with June NAO, suggesting a trade-off between female survival and reproductive success. Both adult female and adult male survival showed low temporal variation, whereas there was high temporal variation in recruitment and breeding productivity. In addition, while annual population growth was positively correlated with annual breeding productivity, a sensitivity analysis revealed that population growth was most sensitive to changes in adult survival. Our results demonstrate that the environmental conditions experienced during a relatively short-time window at the start of the breeding season play a critical role in shaping the demography of a long-distant Arctic migrant. Crucially, different demographic rates responded in opposing directions to climatic variation, emphasising the need for integrated analysis of multiple demographic traits when understanding population dynamics. © 2016 The Authors. Journal of Animal Ecology © 2016 British Ecological Society.

  11. Showing Value (Editorial

    Directory of Open Access Journals (Sweden)

    Denise Koufogiannakis

    2009-06-01

    Full Text Available When Su Cleyle and I first decided to start Evidence Based Library and Information Practice, one of the things we agreed upon immediately was that the journal be open access. We knew that a major obstacle to librarians using the research literature was that they did not have access to the research literature. Although Su and I are both academic librarians who can access a wide variety of library and information literature from our institutions, we belong to a profession where not everyone has equal access to the research in our field. Without such access to our own body of literature, how can we ever hope for practitioners to use research evidence in their decision making? It would have been contradictory to the principles of evidence based library and information practice to do otherwise.One of the specific groups we thought could use such an open access venue for discovering research literature was school librarians. School librarians are often isolated and lacking access to the research literature that may help them prove to stakeholders the importance of their libraries and their role within schools. Certainly, school libraries have been in decline and the use of evidence to show value is needed. As Ken Haycock noted in his 2003 report, The Crisis in Canada’s School Libraries: The Case for Reform and Reinvestment, “Across the country, teacher-librarians are losing their jobs or being reassigned. Collections are becoming depleted owing to budget cuts. Some principals believe that in the age of the Internet and the classroom workstation, the school library is an artifact” (9. Within this context, school librarians are looking to our research literature for evidence of the impact that school library programs have on learning outcomes and student success. They are integrating that evidence into their practice, and reflecting upon what can be improved locally. They are focusing on students and showing the impact of school libraries and

  12. Public medical shows.

    Science.gov (United States)

    Walusinski, Olivier

    2014-01-01

    In the second half of the 19th century, Jean-Martin Charcot (1825-1893) became famous for the quality of his teaching and his innovative neurological discoveries, bringing many French and foreign students to Paris. A hunger for recognition, together with progressive and anticlerical ideals, led Charcot to invite writers, journalists, and politicians to his lessons, during which he presented the results of his work on hysteria. These events became public performances, for which physicians and patients were transformed into actors. Major newspapers ran accounts of these consultations, more like theatrical shows in some respects. The resultant enthusiasm prompted other physicians in Paris and throughout France to try and imitate them. We will compare the form and substance of Charcot's lessons with those given by Jules-Bernard Luys (1828-1897), Victor Dumontpallier (1826-1899), Ambroise-Auguste Liébault (1823-1904), Hippolyte Bernheim (1840-1919), Joseph Grasset (1849-1918), and Albert Pitres (1848-1928). We will also note their impact on contemporary cinema and theatre.

  13. Demographic impact of vaccination: a review.

    Science.gov (United States)

    Bonanni, P

    1999-10-29

    Vaccination is one of the most powerful means to save lives and to increase the level of health of mankind. However, the impact of immunization against the most threatening infectious agents on life expectancy has been the object of a still open debate. The main issues are: the relative influence of nutrition and infectious diseases on demographic patterns of populations; the possibility that lives saved thanks to vaccination are subsequently lost due to other competing causes of death; the positive indirect effect of immunization on other causes of death. With regard to past evidence, several data from the United Kingdom and Scandinavian countries show that the widespread use of smallpox vaccination starting at the beginning of the nineteenth century resulted in a marked and sustained decline not only of smallpox-related deaths, but also of the overall crude death rate, and contributed greatly to an unprecedented growth of European population. As to the present, it is estimated that 3 million children are saved annually by vaccination, but 2 million still die because they are not immunized. Tetanus, measles and pertussis are the main vaccine-preventable killers in the first years of life. Data from Bangladesh show that full implementation of EPI vaccines has the potential of reducing mortality by almost one half in children aged 1-4 years. Recent progress in the development of vaccines against agents responsible for much mortality in the developing countries make it possible to forecast a further substantial reduction of deaths for infectious diseases in the next century.

  14. amily Planning Brings China Demographic Bonus

    Institute of Scientific and Technical Information of China (English)

    马瀛通

    2007-01-01

    Editorial note Scholars around the world are voicing their criticisms on China’s family planning policy,which,in their opinions,will lead to an unhealthy population structure.This article reviews the concepts of"rich before old"and"negative demographic bonus",and concludes that with regards to some indicators such as dependency ratio and demographic bonus,there exists a discrepancy between calculations and reality.The author believes that China will continue to witness a surge of demographic bonus in the future.

  15. A unified framework of demographic time

    DEFF Research Database (Denmark)

    Riffe, Tim; Schöley, Jonas; Villavicencio, Francisco

    Demographic thought and practice is largely conditioned by the Lexis diagram, a two-dimensional graphical representation of the identity between age, period, and birth cohort. This relationship does not account for remaining years of life or other related time measures, whose use in demographic...... research is both underrepresented and incompletely situated. We describe a three-dimensional relationship between six different measures of demographic time: chronological age, time to death, lifespan, time of birth, time of death, and period. We describe four identities among subsets of these six measures...

  16. The Great Cometary Show

    Science.gov (United States)

    2007-01-01

    its high spatial and spectral resolution, it was possible to zoom into the very heart of this very massive star. In this innermost region, the observations are dominated by the extremely dense stellar wind that totally obscures the underlying central star. The AMBER observations show that this dense stellar wind is not spherically symmetric, but exhibits a clearly elongated structure. Overall, the AMBER observations confirm that the extremely high mass loss of Eta Carinae's massive central star is non-spherical and much stronger along the poles than in the equatorial plane. This is in agreement with theoretical models that predict such an enhanced polar mass-loss in the case of rapidly rotating stars. ESO PR Photo 06c/07 ESO PR Photo 06c/07 RS Ophiuchi in Outburst Several papers from this special feature focus on the later stages in a star's life. One looks at the binary system Gamma 2 Velorum, which contains the closest example of a star known as a Wolf-Rayet. A single AMBER observation allowed the astronomers to separate the spectra of the two components, offering new insights in the modeling of Wolf-Rayet stars, but made it also possible to measure the separation between the two stars. This led to a new determination of the distance of the system, showing that previous estimates were incorrect. The observations also revealed information on the region where the winds from the two stars collide. The famous binary system RS Ophiuchi, an example of a recurrent nova, was observed just 5 days after it was discovered to be in outburst on 12 February 2006, an event that has been expected for 21 years. AMBER was able to detect the extension of the expanding nova emission. These observations show a complex geometry and kinematics, far from the simple interpretation of a spherical fireball in extension. AMBER has detected a high velocity jet probably perpendicular to the orbital plane of the binary system, and allowed a precise and careful study of the wind and the shockwave

  17. Changes in sexual behaviour and practice and HIV prevalence indicators among young people aged 15-24 years in Zambia: an in-depth analysis of the 2001-2002 and 2007 Zambia Demographic and Health Surveys.

    Science.gov (United States)

    Kembo, Joshua

    2013-01-01

    HIV and AIDS still pose a major public health problem to most countries in sub-Saharan Africa, Zambia included. The objective of the paper is to determine changes in selected sexual behaviour and practice and HIV prevalence indicators between 2001-2002 and 2007. We used the Demographic and Health Survey Indicators Database for the computation of the selected indicators. We further used STATA 10.0 to compute significance tests to test for statistical difference in the indicators. The results indicate some changes in sexual behaviour, as indicated by an increase in abstinence, use of condoms and the decrease in multiple partnerships. The overall percentage of abstinence among never-married young men and women aged 15-24 years in Zambia increased significantly by 15.2% (p=.000) and 5.9% (p=.001) respectively, between 2001-2002 and 2007. A statistically significant increase of 6.6% (p=.029) was observed in the percentage of young women who reported having used a condom during the last time they had had premarital sex. A statistically significant decrease of 11.0% (p=.000) and 1.4% (p=.000) was observed among young men and women, respectively, who reported having multiple partners in the preceding 12 months. The factorial decomposition using multivariate analysis reveals that the indicators which contributed to the statistically significant 2.6% decline in HIV prevalence among young women aged 15-24 years in Zambia include proportion reporting condom use during premarital sex (+6.6%), abstinence (+5.9%), sex before age 15 (-4.5%), premarital sex (-2.6%), sex before age 18 (-2.4%) and proportion reporting multiple partnerships (-1.4%). Remarkable strides have been achieved towards promoting responsible sexual behaviour and practice among young people in Zambia. Further research focusing on factors that predispose young women in Zambia to higher risk of infection from HIV is required. The results from this paper should be useful in the design of programmes to control the

  18. Impact of environmental factors on the demographic characteristics in Tomsk Oblast (Russia, 1980-2015)

    Science.gov (United States)

    Pugacheva, E.; Mezhibor, A.; Makarenko, T.

    2016-09-01

    The research represents the analysis of essential demographic indexes in Tomsk Oblast (Russia): birth-rate, death-rate, natural increase (1980-2015), migration increase (19972014), and child mortality (1990-2015). Environmental factors were determined as influencing the health and as a consequence, having the impact on the demographic characteristics of the studied region.

  19. STATISTICAL EVALUATION OF THE IMPACT OF ECONOMIC FACTORS ON SOCIO-DEMOGRAPHICS OF THE COUNTRY

    Directory of Open Access Journals (Sweden)

    O. Evseenko

    2014-04-01

    Full Text Available In theory made a case the necessity of modeling economic and demographic indicators. The influences of economic, social and environmental indicators on social and demographic factors of development country are researeched. Given statistical evaluation of relationships based on correlation and regression analysis method.

  20. Individual patient data meta-analysis shows a significant association between the ATM rs1801516 SNP and toxicity after radiotherapy in 5456 breast and prostate cancer patients

    DEFF Research Database (Denmark)

    Andreassen, Christian Nicolaj; Rosenstein, Barry S; Kerns, Sarah L

    2016-01-01

    PURPOSE: Several small studies have indicated that the ATM rs1801516 SNP is associated with risk of normal tissue toxicity after radiotherapy. However, the findings have not been consistent. In order to test this SNP in a well-powered study, an individual patient data meta-analysis was carried ou...

  1. Factores institucionales, pedagógicos, psicosociales y sociodemográficos asociados al rendimiento académico en la Universidad de Costa Rica: un análisis multinivel. [Institutional, pedagogical, psychosocial and socio-demographic factors related to academic performance at the University of Costa Rica: a multilevel analysis

    Directory of Open Access Journals (Sweden)

    Montero Rojas, Eiliana

    2007-10-01

    Full Text Available A multilevel analysis was conducted to predict final grades in courses from different majors for a sample, stratified by academic areas, of 848 students at the University of Costa Rica. A group of factors from institutional, socio-demographic, psychosocial and pedagogical aspects were employed as independent variables. The best predictor was the Admission Average, which combines grades from high school and an aptitude test score. Some non-cognitive variables were also explicative; the most important being the score on a scale of emotional intelligence. The methodology employed by the professor showed explicative power as well. Se realizó un análisis multinivel para predecir calificaciones finales en cursos de carrera, para una muestra estratificada, por áreas académicas, de 848 estudiantes de la Universidad de Costa Rica. Se utilizaron como variables independientes un conjunto de factores en dimensiones institucionales, sociodemográficas, psicosociales y pedagógicas. El mejor predictor fue el Promedio de Admisión, medida que combina notas de secundaria y el puntaje en una prueba de habilidades de razonamiento. También variables no cognitivas resultaron explicativas, siendo la más importante el puntaje de una escala de inteligencia emocional. La metodología empleada por el (la docente mostró asimismo poder explicativo.

  2. Population expansions dominate demographic histories of endemic and widespread Pacific reef fishes

    Science.gov (United States)

    Delrieu-Trottin, Erwan; Mona, Stefano; Maynard, Jeffrey; Neglia, Valentina; Veuille, Michel; Planes, Serge

    2017-01-01

    Despite the unique nature of endemic species, their origin and population history remain poorly studied. We investigated the population history of 28 coral reef fish species, close related, from the Gambier and Marquesas Islands, from five families, with range size varying from widespread to small-range endemic. We analyzed both mitochondrial and nuclear sequence data using neutrality test and Bayesian analysis (EBSP and ABC). We found evidence for demographic expansions for most species (24 of 28), irrespective of range size, reproduction strategy or archipelago. The timing of the expansions varied greatly among species, from 8,000 to 2,000,000 years ago. The typical hypothesis for reef fish that links population expansions to the Last Glacial Maximum fit for 14 of the 24 demographic expansions. We propose two evolutionary processes that could lead to expansions older than the LGM: (a) we are retrieving the signature of an old colonization process for widespread, large-range endemic and paleoendemic species or (b) speciation; the expansion reflects the birth of the species for neoendemic species. We show for the first time that the demographic histories of endemic and widespread reef fish are not distinctly different and suggest that a number of processes drive endemism. PMID:28091580

  3. Population expansions dominate demographic histories of endemic and widespread Pacific reef fishes

    Science.gov (United States)

    Delrieu-Trottin, Erwan; Mona, Stefano; Maynard, Jeffrey; Neglia, Valentina; Veuille, Michel; Planes, Serge

    2017-01-01

    Despite the unique nature of endemic species, their origin and population history remain poorly studied. We investigated the population history of 28 coral reef fish species, close related, from the Gambier and Marquesas Islands, from five families, with range size varying from widespread to small-range endemic. We analyzed both mitochondrial and nuclear sequence data using neutrality test and Bayesian analysis (EBSP and ABC). We found evidence for demographic expansions for most species (24 of 28), irrespective of range size, reproduction strategy or archipelago. The timing of the expansions varied greatly among species, from 8,000 to 2,000,000 years ago. The typical hypothesis for reef fish that links population expansions to the Last Glacial Maximum fit for 14 of the 24 demographic expansions. We propose two evolutionary processes that could lead to expansions older than the LGM: (a) we are retrieving the signature of an old colonization process for widespread, large-range endemic and paleoendemic species or (b) speciation; the expansion reflects the birth of the species for neoendemic species. We show for the first time that the demographic histories of endemic and widespread reef fish are not distinctly different and suggest that a number of processes drive endemism.

  4. Demographic cycles, cohort size, and earnings.

    Science.gov (United States)

    Berger, M C

    1989-05-01

    This article examines whether position in the demographic cycle is an important factor in determining earnings and earnings growth. Earnings equations for white males are estimated by using March Current Population Survey data. Position in the demographic cycle is captured by including both measures of own cohort size and the size of surrounding cohorts in the estimated earnings equations. Position in the demographic cycle matters. Increases in own cohort size lead to flatter earnings profiles, whereas increases in the size of surrounding cohorts are associated with steeper earnings profiles. The net effect is that those who enter the labor market before or after the peak of the demographic cycle start out with lower earnings but experience faster earnings growth. This pattern is uniform across all schooling groups: high school dropouts, high school graduates, those with some college, and college graduates.

  5. The demographic work of Sir William Wilde.

    Science.gov (United States)

    Froggatt, P

    2016-05-01

    This paper argues that Sir William Wilde was indeed a pioneering demographer. It also describes the unveiling of the plaque commemorating Sir William Wilde at his home, 1, Merrion Square, Dublin on the 28 October 1971.

  6. Demographics and presenting clinical features of childhood ...

    African Journals Online (AJOL)

    Demographics and presenting clinical features of childhood systemic lupus ... and characteristics of children with systemic lupus erythematosus (SLE). ... Rashes were found to be the commonest clinical feature present at the time of diagnosis, ...

  7. Demographic heterogeneity, cohort selection, and population growth

    OpenAIRE

    Bruce E. Kendall; Fox, Gordon A.; Fujiwara, Masami; Nogeire, Theresa M.

    2011-01-01

    Demographic heterogeneity—variation among individuals in survival and reproduction—is ubiquitous in natural populations. Structured population models address heterogeneity due to age, size, or major developmental stages. However, other important sources of demographic heterogeneity, such as genetic variation, spatial heterogeneity in the environment, maternal effects, and differential exposure to stressors, are often not easily measured and hence are modeled as stochasticity. Recent research ...

  8. Single-Cell Analysis and Next-Generation Immuno-Sequencing Show That Multiple Clones Persist in Patients with Chronic Lymphocytic Leukemia.

    Directory of Open Access Journals (Sweden)

    Jitra Kriangkum

    Full Text Available The immunoglobulin heavy chain (IGH gene rearrangement in chronic lymphocytic leukemia (CLL provides a unique molecular signature; however, we demonstrate that 26/198 CLL patients (13% had more than one IGH rearrangement, indicating the power of molecular technology over phenotypic analysis. Single-cell PCR analysis and next-generation immuno-sequencing identified IGH-defined clones. In 23% (18/79 of cases whose clones carried unmutated immunoglobulin heavy chain variable (IGHV genes (U-CLL, IGH rearrangements were bialleic with one productive (P and one non-productive (NP allele. Two U-CLL were biclonal, each clone being monoallelic (P. In 119 IGHV-mutated (M-CLL cases, one had biallelic rearrangements in their CLL (P/NP and five had 2-4 distinct clones. Allelic exclusion was maintained in all B-clones analyzed. Based on single-cell PCR analysis, 5/11 partner clones (45% reached levels of >5x10(9 cells/L, suggesting second CLL clones. Partner clones persisted over years. Conventional IGH characterization and next-generation sequencing of 13 CLL, 3 multiple myeloma, 2 Waldenstrom's macroglobulinemia and 3 age-matched healthy donors consistently identified the same rearranged IGH sequences. Most multiple clones occurred in M-CLL, perhaps indicative of weak clonal dominance, thereby associating with a good prognosis. In contrast, biallelic CLL occurred primarily in U-CLL thus being associated with poor prognosis. Extending beyond intra-clonal diversity, molecular analysis of clonal evolution and apparent subclones in CLL may also reflect inter-clonal diversity.

  9. Demographic determinants of delayed divorce.

    Science.gov (United States)

    Chan, L Y; Heaton, T B

    1989-01-01

    This study identifies factors that predict delayed divorce in the US. The findings show that factors which influence marital stability in general also correlate with delayed divorce in the same direction. Wife's age at marriage, age of the youngest child, wife's religion, region of residence, and metropolitan residence have substantial effects of delayed divorce, but the effects of race, parental divorce, premarital pregnancy, and socioeconomic status are small.

  10. Two centuries of demographic change in Canada

    Directory of Open Access Journals (Sweden)

    Barry Edmonston

    2014-03-01

    Full Text Available One key aspect of the demographic transition—the shift from high mortality and high fertility to low mortality and low fertility is a major change in the population’s age distribution from a pyramid-shaped young age structure to a pillar-shaped old age structure. This paper discusses two demographic processes affected by changes in age structure. First, there are effects on vital rates, with important differences in the observed crude rates and the implied intrinsic vital rates. Second, changes in age structure influence population momentum. More recently, demographers have noted that older age distributions associated with fertility levels below replacement have negative population momentum. Although the demographic transition has been well-described for many countries, demographers have seldom analyzed intrinsic vital rates and population momentum over time, which are dynamic processes affected by changes in the population age structure and which, in turn, influence future changes in population growth and size. This paper uses new data and methods to analyze intrinsic vital rates and population momentum across two centuries of demographic change in Canada

  11. Demographics of Resonances in Exoplanetary Systems

    Science.gov (United States)

    Ragozzine, Darin; Conaway, James L.; MacDonald, Mariah G.; Sallee, Victor

    2016-10-01

    NASA's Kepler Space Telescope has identified ~700 systems of multiple transiting exoplanets containing ~1700 planets. Most of these multi-transiting systems have 3-5 planets small planets with periods of roughly 5-50 days and are known as Systems with Tightly-spaced Inner Planets (STIPs). These information-rich exoplanetary systems have precisely measured period ratios which allows for the identification and characterization of orbital mean motion resonances. Improved understanding of the resonant populations will reveal much about the formation and evolution of planetary systems. Lissauer, Ragozzine, et al. 2011 found that most Kepler systems were not in resonance, but that there was a small excess of planets wide of resonance. We present new analyses that rigorously identify the frequency of planets in multiple resonances (including three-body resonances) and thus identify many specific new results on the demographics of resonances. We also show that the apparent over-abundance of resonances can be attributed to a difference in inclinations (potentially from dissipation) with implications for the true underlying frequency of resonant systems. We compare the period ratio distribution of Kepler (corrected for inclination biases) to Radial Velocity (RV) surveys and conclude that RV systems are often missing small intermediate planets. This has serious implications for the completeness of RV identification of planets in STIPs.

  12. Analysis on Popular Program of "The Generation Show" from Communication Perspective%《年代秀》热播的传播学解读

    Institute of Scientific and Technical Information of China (English)

    胡亚婷

    2012-01-01

    2011年5月27日深圳卫视推出全明星代际互动综艺节目《年代秀》,不仅赢得了观众追捧,而且获得了社会好评。本文从传播学的角度对这一较新的传播现象进行了解读。《年代秀》的开播贴合了中国当前的社会文化背景,顺应了综艺节目的发展潮流。节目中浓浓怀旧情怀的呈现、明星策略的运用抓住了电视观众的眼球;高品味的文化内涵又体现出电视媒介的社会责任。这些都是促成节目热播的关键因素。%Shenzhen TV on May 27, 2011 launched All-Star Intergenerational Interaction Variety Show "The Generation Show". It wins not only the audience but also acclaims. This article analyses the relatively new phenomenon from perspective of communication. The show fits Chinese current social cultural background and conforms to the trend of development of the variety show. Its nostalgic feelings, star strategy and high taste of cultural connotation altogether attract the audience' s egeball, making all of these key factors contributing to the show' s success.

  13. Demographics of the European apicultural industry.

    Directory of Open Access Journals (Sweden)

    Marie-Pierre Chauzat

    Full Text Available Over the last few years, many European and North American countries have reported a high rate of disorders (mortality, dwindling and disappearance affecting honeybee colonies (Apis mellifera. Although beekeeping has become an increasingly professional activity in recent years, the beekeeping industry remains poorly documented in Europe. The European Union Reference Laboratory for Honeybee Health sent a detailed questionnaire to each Member State, in addition to Kosovo and Norway, to determine the demographics and state of their beekeeping industries. Based on data supplied by the National Reference Laboratory for honeybee diseases in each European country, a European database was created to describe the beekeeping industry including the number and types of beekeepers, operation size, industry production, and health (notifiable diseases, mortalities. The total number of beekeepers in Europe was estimated at 620,000. European honey production was evaluated at around 220,000 tons in 2010. The price of honey varied from 1.5 to 40 €/kg depending on the country and on the distribution network. The estimated colony winter mortality varied from 7 to 28% depending on the country and the origin of the data (institutional survey or beekeeping associations. This survey documents the high heterogeneity of the apicultural industry within the European Union. The high proportion of non-professional beekeepers and the small mean number of colonies per beekeeper were the only common characteristics at European level. The tremendous variation in European apicultural industries has implication for any comprehensive epidemiological or economic analysis of the industry. This variability needs to be taken into account for such analysis as well as for future policy development. The industry would be served if beekeeping registration was uniformly implemented across member states. Better information on the package bee and queen production would help in understanding

  14. Demographics of the European apicultural industry.

    Science.gov (United States)

    Chauzat, Marie-Pierre; Cauquil, Laura; Roy, Lise; Franco, Stéphanie; Hendrikx, Pascal; Ribière-Chabert, Magali

    2013-01-01

    Over the last few years, many European and North American countries have reported a high rate of disorders (mortality, dwindling and disappearance) affecting honeybee colonies (Apis mellifera). Although beekeeping has become an increasingly professional activity in recent years, the beekeeping industry remains poorly documented in Europe. The European Union Reference Laboratory for Honeybee Health sent a detailed questionnaire to each Member State, in addition to Kosovo and Norway, to determine the demographics and state of their beekeeping industries. Based on data supplied by the National Reference Laboratory for honeybee diseases in each European country, a European database was created to describe the beekeeping industry including the number and types of beekeepers, operation size, industry production, and health (notifiable diseases, mortalities). The total number of beekeepers in Europe was estimated at 620,000. European honey production was evaluated at around 220,000 tons in 2010. The price of honey varied from 1.5 to 40 €/kg depending on the country and on the distribution network. The estimated colony winter mortality varied from 7 to 28% depending on the country and the origin of the data (institutional survey or beekeeping associations). This survey documents the high heterogeneity of the apicultural industry within the European Union. The high proportion of non-professional beekeepers and the small mean number of colonies per beekeeper were the only common characteristics at European level. The tremendous variation in European apicultural industries has implication for any comprehensive epidemiological or economic analysis of the industry. This variability needs to be taken into account for such analysis as well as for future policy development. The industry would be served if beekeeping registration was uniformly implemented across member states. Better information on the package bee and queen production would help in understanding the ability of

  15. Combined analysis of 19 common validated type 2 diabetes susceptibility gene variants shows moderate discriminative value and no evidence of gene-gene interaction

    DEFF Research Database (Denmark)

    Sparsø, T; Grarup, N; Andreasen, C;

    2009-01-01

    AIMS/HYPOTHESIS: The list of validated type 2 diabetes susceptibility variants has recently been expanded from three to 19. The variants identified are common and have low penetrance in the general population. The aim of the study is to investigate the combined effect of the 19 variants by applyi...... analysis of the 19 validated variants enables detection of subgroups at substantially increased risk of type 2 diabetes; however, the discrimination between glucose-tolerant and type 2 diabetes individuals is still too inaccurate to achieve clinical value....

  16. Common Mental Disorders: socio-demographic and pharmacotherapy profile

    Directory of Open Access Journals (Sweden)

    Viviane Ferrari Gomes

    2013-12-01

    Full Text Available OBJECTIVE: this study reports an association between Common Mental Disorders and the socio-demographic and pharmacotherapy profiles of 106 patients cared for by a Primary Health Care unit in the interior of São Paulo, Brazil. METHOD: this is a cross-sectional descriptive exploratory study with a quantitative approach. Structured interviews and validated instruments were used to collect data. The Statistical Package for Social Science was used for analysis. RESULTS: The prevalence of Common Mental Disorders was 50%. An association was found between Common Mental Disorders and the variables occupation, family income, number of prescribed medications and number of pills taken a day. Greater therapy non-adherence was observed among those who tested positive for Common Mental Disorders. CONCLUSION: this study's results show the importance of health professionals working in PHC to be able to detect needs of a psychological nature among their patients and to support the implementation of actions to prevent the worsening of Common Mental Disorders.

  17. 'You want to show you're a valuable employee': A critical discourse analysis of multi-perspective portrayals of employed women with fibromyalgia.

    Science.gov (United States)

    Oldfield, Margaret; MacEachen, Ellen; MacNeill, Margaret; Kirsh, Bonnie

    2017-01-01

    Background Advice on fibromyalgia, a chronic illness primarily affecting women, often presents it as incompatible with work and rarely covers how to remain employed. Yet many women do. Objectives We aimed to understand how these women, their family members, and workmates portrayed employees with fibromyalgia, and how these portrayals helped women retain employment. Methods We interviewed 22 participants, comprising five triads and three dyads of people who knew each other. Using the methodology of critical discourse analysis, we analysed the interview data within and across the triads/dyads through coding, narrative summaries, and relational mapping. Results Participants reported stereotypes that employees with fibromyalgia are lazy, malingering, and less productive than healthy workers. Countering these assumptions, participants portrayed the women as normal, valuable employees who did not 'give in' to their illness. The portrayals drew on two discourses, normalcy and mind-controlling-the-body, and a related narrative, overcoming disability. We propose that participants' portrayals helped women manage their identities in competitive workplaces and thereby remain employed. Discussion Our findings augment the very sparse literature on employment with fibromyalgia. Using a new approach, critical discourse analysis, we expand on known job-retention strategies and add the perspectives of two key stakeholders: family members and workmates.

  18. An Analysis of the Popular Reality Shows of Stars ’ Travel%试析明星旅行类真人秀节目热播现象

    Institute of Scientific and Technical Information of China (English)

    芦锦霞

    2015-01-01

    Nearly one or two years, reality shows which are in the form of stars ’ travel and with different themes are popular on TV. They did well with many viewers and also received good ratings. The reason of the popularity of the reality shows of stars ’ travel is that they contain seven elements of reality shows: willing participants, given situations, objectives, rules, competitive behaviors, the real record, the artistic processing, also they can fully satisfy people’s pursuit of truth, goodness and beauty.%近一两年,以旅行为形式的主题各异的明星真人秀节目在电视荧屏上层出不穷,受到了观众的喜爱与好评,获得了不俗的收视率。明星旅行类真人秀节目热播的原因在于它包含了真人秀的七大元素———自愿参与者、规定情境、目的、规则、竞赛行为、真实记录、艺术加工,全方位地满足了人们对于真、善、美的追求。

  19. Diffusion tensor MRI shows progressive changes in the hippocampus and dentate gyrus after status epilepticus in rat - histological validation with Fourier-based analysis.

    Science.gov (United States)

    Salo, Raimo A; Miettinen, Tuukka; Laitinen, Teemu; Gröhn, Olli; Sierra, Alejandra

    2017-03-04

    Imaging markers for monitoring disease progression, recovery, and treatment efficacy are a major unmet need for many neurological diseases, including epilepsy. Recent evidence suggests that diffusion tensor imaging (DTI) provides high microstructural contrast even outside major white matter tracts. We hypothesized that in vivo DTI could detect progressive microstructural changes in the dentate gyrus and the hippocampal CA3bc in the rat brain after status epilepticus (SE). To test this hypothesis, we induced SE with systemic kainic acid or pilocarpine in adult male Wistar rats and subsequently scanned them using in vivo DTI at five time-points: prior to SE, and 10, 20, 34, and 79 days post SE. In order to tie the DTI findings to changes in the tissue microstructure, myelin- and glial fibrillary acidic protein (GFAP)-stained sections from the same animals underwent Fourier analysis. We compared the Fourier analysis parameters, anisotropy index and angle of myelinated axons or astrocyte processes, to corresponding DTI parameters, fractional anisotropy (FA) and the orientation angle of the principal eigenvector. We found progressive detectable changes in DTI parameters in both the dentate gyrus (FA, axial diffusivity [D||], linear anisotropy [CL] and spherical anisotropy [CS], pmixed-effects model [LMEM]) and the CA3bc (FA, D||, CS, and angle, p<0.001, LMEM; CL and planar anisotropy [CP], p<0.01, LMEM) post SE. The Fourier analysis revealed that both myelinated axons and astrocyte processes played a role in the water diffusion anisotropy changes detected by DTI in individual portions of the dentate gyrus (suprapyramidal blade, mid-portion, and infrapyramidal blade). In the whole dentate gyrus, myelinated axons markedly contributed to the water diffusion changes. In CA3bc as well as in CA3b and CA3c, both myelinated axons and astrocyte processes contributed to water diffusion anisotropy and orientation. Our study revealed that DTI is a promising method for noninvasive

  20. Retrospective Analysis of Serotype Switching of Vibrio cholerae O1 in a Cholera Endemic Region Shows It Is a Non-random Process

    Science.gov (United States)

    Karlsson, Stefan L.; Thomson, Nicholas; Mutreja, Ankur; Connor, Thomas; Sur, Dipika; Ali, Mohammad; Clemens, John; Dougan, Gordon; Holmgren, Jan; Lebens, Michael

    2016-01-01

    Genomic data generated from clinical Vibrio cholerae O1 isolates collected over a five year period in an area of Kolkata, India with seasonal cholera outbreaks allowed a detailed genetic analysis of serotype switching that occurred from Ogawa to Inaba and back to Ogawa. The change from Ogawa to Inaba resulted from mutational disruption of the methyltransferase encoded by the wbeT gene. Re-emergence of the Ogawa serotype was found to result either from expansion of an already existing Ogawa clade or reversion of the mutation in an Inaba clade. Our data suggests that such transitions are not random events but rather driven by as yet unidentified selection mechanisms based on differences in the structure of the O1 antigen or in the serotype-determining wbeT gene. PMID:27706170

  1. Retrospective Analysis of Serotype Switching of Vibrio cholerae O1 in a Cholera Endemic Region Shows It Is a Non-random Process.

    Science.gov (United States)

    Karlsson, Stefan L; Thomson, Nicholas; Mutreja, Ankur; Connor, Thomas; Sur, Dipika; Ali, Mohammad; Clemens, John; Dougan, Gordon; Holmgren, Jan; Lebens, Michael

    2016-10-01

    Genomic data generated from clinical Vibrio cholerae O1 isolates collected over a five year period in an area of Kolkata, India with seasonal cholera outbreaks allowed a detailed genetic analysis of serotype switching that occurred from Ogawa to Inaba and back to Ogawa. The change from Ogawa to Inaba resulted from mutational disruption of the methyltransferase encoded by the wbeT gene. Re-emergence of the Ogawa serotype was found to result either from expansion of an already existing Ogawa clade or reversion of the mutation in an Inaba clade. Our data suggests that such transitions are not random events but rather driven by as yet unidentified selection mechanisms based on differences in the structure of the O1 antigen or in the serotype-determining wbeT gene.

  2. Analysis of the Fgfr2C342Y mouse model shows condensation defects due to misregulation of Sox9 expression in prechondrocytic mesenchyme

    Science.gov (United States)

    Peskett, Emma; Kumar, Samin; Baird, William; Jaiswal, Janhvi; Li, Ming; Patel, Priyanca; Britto, Jonathan A.

    2017-01-01

    ABSTRACT Syndromic craniosynostosis caused by mutations in FGFR2 is characterised by developmental pathology in both endochondral and membranous skeletogenesis. Detailed phenotypic characterisation of features in the membranous calvarium, the endochondral cranial base and other structures in the axial and appendicular skeleton has not been performed at embryonic stages. We investigated bone development in the Crouzon mouse model (Fgfr2C342Y) at pre- and post-ossification stages to improve understanding of the underlying pathogenesis. Phenotypic analysis was performed by whole-mount skeletal staining (Alcian Blue/Alizarin Red) and histological staining of sections of CD1 wild-type (WT), Fgfr2C342Y/+ heterozygous (HET) and Fgfr2C342Y/C342Y homozygous (HOM) mouse embryos from embryonic day (E)12.5-E17.5 stages. Gene expression (Sox9, Shh, Fgf10 and Runx2) was studied by in situ hybridisation and protein expression (COL2A1) by immunohistochemistry. Our analysis has identified severely decreased osteogenesis in parts of the craniofacial skeleton together with increased chondrogenesis in parts of the endochondral and cartilaginous skeleton in HOM embryos. The Sox9 expression domain in tracheal and basi-cranial chondrocytic precursors at E13.5 in HOM embryos is increased and expanded, correlating with the phenotypic observations which suggest FGFR2 signalling regulates Sox9 expression. Combined with abnormal staining of type II collagen in pre-chondrocytic mesenchyme, this is indicative of a mesenchymal condensation defect. An expanded spectrum of phenotypic features observed in the Fgfr2C342Y/C342Y mouse embryo paves the way towards better understanding the clinical attributes of human Crouzon–Pfeiffer syndrome. FGFR2 mutation results in impaired skeletogenesis; however, our findings suggest that many phenotypic aberrations stem from a primary failure of pre-chondrogenic/osteogenic mesenchymal condensation and link FGFR2 to SOX9, a principal regulator of skeletogenesis

  3. Genome-wide analysis of primary CD4+ and CD8+ T cell transcriptomes shows evidence for a network of enriched pathways associated with HIV disease

    Directory of Open Access Journals (Sweden)

    Wang Bin

    2011-03-01

    Full Text Available Abstract Background HIV preferentially infects CD4+ T cells, and the functional impairment and numerical decline of CD4+ and CD8+ T cells characterize HIV disease. The numerical decline of CD4+ and CD8+ T cells affects the optimal ratio between the two cell types necessary for immune regulation. Therefore, this work aimed to define the genomic basis of HIV interactions with the cellular transcriptome of both CD4+ and CD8+ T cells. Results Genome-wide transcriptomes of primary CD4+ and CD8+ T cells from HIV+ patients were analyzed at different stages of HIV disease using Illumina microarray. For each cell subset, pairwise comparisons were performed and differentially expressed (DE genes were identified (fold change >2 and B-statistic >0 followed by quantitative PCR validation. Gene ontology (GO analysis of DE genes revealed enriched categories of complement activation, actin filament, proteasome core and proton-transporting ATPase complex. By gene set enrichment analysis (GSEA, a network of enriched pathways functionally connected by mitochondria was identified in both T cell subsets as a transcriptional signature of HIV disease progression. These pathways ranged from metabolism and energy production (TCA cycle and OXPHOS to mitochondria meditated cell apoptosis and cell cycle dysregulation. The most unique and significant feature of our work was that the non-progressing status in HIV+ long-term non-progressors was associated with MAPK, WNT, and AKT pathways contributing to cell survival and anti-viral responses. Conclusions These data offer new comparative insights into HIV disease progression from the aspect of HIV-host interactions at the transcriptomic level, which will facilitate the understanding of the genetic basis of transcriptomic interaction of HIV in vivo and how HIV subverts the human gene machinery at the individual cell type level.

  4. Genetic complementation analysis showed distinct contributions of the N-terminal tail of H2A.Z to epigenetic regulations.

    Science.gov (United States)

    Kusakabe, Masayuki; Oku, Hiroyuki; Matsuda, Ryo; Hori, Tetsuya; Muto, Akihiko; Igarashi, Kazuhiko; Fukagawa, Tatsuo; Harata, Masahiko

    2016-02-01

    H2A.Z is one of the most evolutionally conserved histone variants. In vertebrates, this histone variant has two isoforms, H2A.Z.1 and H2A.Z.2, each of which is coded by an individual gene. H2A.Z is involved in multiple epigenetic regulations, and in humans, it also has relevance to carcinogenesis. In this study, we used the H2A.Z DKO cells, in which both H2A.Z isoform genes could be inducibly knocked out, for the functional analysis of H2A.Z by a genetic complementation assay, as the first example of its kind in vertebrates. Ectopically expressed wild-type H2A.Z and two N-terminal mutants, a nonacetylable H2A.Z mutant and a chimera in which the N-terminal tail of H2A.Z.1 was replaced with that of the canonical H2A, complemented the mitotic defects of H2A.Z DKO cells similarly, suggesting that both acetylation and distinctive sequence of the N-terminal tail of H2A.Z are not required for mitotic progression. In contrast, each one of these three forms of H2A.Z complemented the transcriptional defects of H2A.Z DKO cells differently. These results suggest that the N-terminal tail of vertebrate H2A.Z makes distinctively different contributions to these epigenetic events. Our results also imply that this genetic complementation system is a novel and useful tool for the functional analysis of H2A.Z.

  5. Genome analysis shows Bacillus axarquiensis is not a later heterotypic synonym of Bacillus mojavensis; reclassification of Bacillus malacitensis and Brevibacterium halotolerans as heterotypic synonyms of Bacillus axarquiensis.

    Science.gov (United States)

    Dunlap, Christopher A; Bowman, Michael J; Schisler, David A; Rooney, Alejandro P

    2016-06-01

    Bacillus axarquiensis and Bacillus malacitensis were previously reported to be later heterotypic synonyms of Bacillus mojavensis, based primarily on DNA-DNA relatedness values. We have sequenced draft genomes of Bacillus axarquiensis NRRL B-41617T and Bacillus malacitensis NRRL B-41618T. Comparative genomics and DNA-DNA relatedness calculations showed that while Bacillus axarquiensis and Bacillus malacitensis are synonymous with each other, they are not synonymous with Bacillus mojavensis. In addition, a draft genome was completed for Brevibacterium halotolerans, a strain long suspected of being a Bacillus subtilis group member based on 16S rRNA similarities (99.8 % with Bacillus mojavensis). Comparative genomics and DNA-DNA relatedness calculations showed that Brevibacterium halotolerans is synonymous with Bacillus axarquiensis and Bacillus malacitensis. The pairwise in silico DNA-DNA hybridization values calculated in comparisons between the three conspecific strains were all greater than 92 %, which is well above the standard species threshold of 70 %. While the pairwise in silico DNA-DNA hybridization values calculated in comparisons of the three conspecific strains with Bacillus mojavensis were all less than 65 %. The combined results of our genotype and phenotype studies showed that Bacillus axarquiensis, Bacillus malacitensis and Brevibacterium halotolerans are conspecific and distinct from Bacillus mojavensis. Because the valid publication of the name Bacillus axarquiensis predates the publication of the name Bacillus malacitensis, we propose that Bacillus malacitensis be reclassified as a synonym of Bacillus axarquiensis. In addition, we propose to reclassify Brevibacterium halotolerans as a synonym of Bacillus axarquiensis. An amended description of Bacillus axarquiensis is provided.

  6. Analysis of S gene mutation of the hepatitis B virus in adult liver transplant recipients showing resistance to hepatitis B immunoglobulin therapy.

    Science.gov (United States)

    Park, G-C; Hwang, S; Ahn, C-S; Kim, K-H; Moon, D-B; Ha, T-Y; Song, G-W; Jung, D-H; Shin, Y W; Kim, S-H; Chang, K-H; Namgoong, J-M; Park, C-S; Park, H-W; Park, Y-H; Kang, S-H; Jung, B-H; Lee, S-G

    2013-10-01

    A considerable proportion of recipients of liver transplantations who are presented hepatitis B immunoglobulin (HBIG) monotherapy for hepatitis B virus (HBV) prophylaxis develop HBIG resistance. In this study, we investigated the mutation patterns in the major hydrophilic region (MHR) of amino acid sequences 100 to 160. Using the gene sequence analyzer for amino acid sequences 0 to 226 in the S/pre-S region we analyzed blood samples of 15 patients showing HBIG resistance after high-dose HBIG prophylaxis. Various mutations in the MHR were observed in 14/15 samples: Gly145Arg mutation in 8/13 Adr subtype and 1/2 Ayw subtype samples (60%). The next most common mutation was Gly165Trp in 8/13 Adr subtype but neither of 2 Ayw subtype samples (53.3%). Concurrent antiviral resistance was noted in 5 patients: lamivudine (n = 5), or entecavir (n = 3), but not adefovir, suggesting the occurrence of simultaneous, antiviral cross-resistances. Two patients underwent retransplantation due to the progression of HBV infection despite vigorous antiviral therapy. At diagnosis of HBV recurrence, the mean HBV DNA load was 6.5 × 10(6) copies/mL; 4 patients showed paradoxical coexistence of anti-HBs and HBsAg. Currently, 2 subjects show low-level HBV DNA replication in peripheral blood, although the other 12 had no DNA replication after prolonged antiviral therapy. This study suggested that various mutations in the "a" determinant were associated with HBIG resistance. Since treatment failure to rescue antiviral therapy was often associated with delayed detection of HBV recurrence rather than concurrent antiviral resistance, frequent HBV surveillance using more sensitive screening tests, such as HBeAg and HBV DNA polymerase chain reaction assay, seems to be mandatory. Copyright © 2013 Elsevier Inc. All rights reserved.

  7. Demographics of mass customization: a global study of manufacturing plants

    Directory of Open Access Journals (Sweden)

    Giovani José Caetano da Silveira

    2016-03-01

    Full Text Available Abstract This study explores the demographic configuration of mass customization (MC manufacturing plants. It uses cluster analysis, ANOVA and correspondence analysis to test for differences in business unit size, location, and supply chain structure between MC and non-MC producers across the globe. The analysis uses data from an international survey of manufacturers of metal products, machinery, and instruments from 21 countries. Results indicate no significant differences in size, but significant differences in location and supply chain indicators between MC and non-MC plants. We also find renewed evidence of the positioning of MC plants in Hayes & Wheelwright's (1979 product and process matrix.

  8. Structure, variation and expression analysis of glutenin gene promoters from Triticum aestivum cultivar Chinese Spring shows the distal region of promoter 1Bx7 is key regulatory sequence.

    Science.gov (United States)

    Wang, Kai; Zhang, Xue; Zhao, Ying; Chen, Fanguo; Xia, Guangmin

    2013-09-25

    In this study, ten glutenin gene promoters were isolated from model wheat (Triticum aestivum L. cv. Chinese Spring) using a genomic PCR strategy with gene-specific primers. Six belonged to high-molecular-weight glutenin subunit (HMW-GS) gene promoters, and four to low-molecular-weight glutenin subunit (LMW-GS). Sequence lengths varied from 1361 to 2,554 bp. We show that the glutenin gene promoter motifs are conserved in diverse sequences in this study, with HMW-GS and LMW-GS gene promoters characterized by distinct conserved motif combinations. Our findings show that HMW-GS promoters contain more functional motifs in the distal region of the glutenin gene promoter (> -700 bp) compared with LMW-GS. The y-type HMW-GS gene promoters possess unique motifs including RY repeat and as-2 box compared to the x-type. We also identified important motifs in the distal region of HMW-GS gene promoters including the 5'-UTR Py-rich stretch motif and the as-2 box motif. We found that cis-acting elements in the distal region of promoter 1Bx7 enhanced the expression of HMW-GS gene 1Bx7. Taken together, these data support efforts in designing molecular breeding strategies aiming to improve wheat quality. Our results offer insight into the regulatory mechanisms of glutenin gene expression.

  9. Identification and analysis of unitary loss of long-established protein-coding genes in Poaceae shows evidences for biased gene loss and putatively functional transcription of relics.

    Science.gov (United States)

    Zhao, Yi; Tang, Liang; Li, Zhe; Jin, Jinpu; Luo, Jingchu; Gao, Ge

    2015-04-18

    Long-established protein-coding genes may lose their coding potential during evolution ("unitary gene loss"). Members of the Poaceae family are a major food source and represent an ideal model clade for plant evolution research. However, the global pattern of unitary gene loss in Poaceae genomes as well as the evolutionary fate of lost genes are still less-investigated and remain largely elusive. Using a locally developed pipeline, we identified 129 unitary gene loss events for long-established protein-coding genes from four representative species of Poaceae, i.e. brachypodium, rice, sorghum and maize. Functional annotation suggested that the lost genes in all or most of Poaceae species are enriched for genes involved in development and response to endogenous stimulus. We also found that 44 mutated genomic loci of lost genes, which we referred as relics, were still actively transcribed, and of which 84% (37 of 44) showed significantly differential expression across different tissues. More interestingly, we found that there were totally five expressed relics may function as competitive endogenous RNA in brachypodium, rice and sorghum genome. Based on comparative genomics and transcriptome data, we firstly compiled a comprehensive catalogue of unitary gene loss events in Poaceae species and characterized a statistically significant functional preference for these lost genes as well showed the potential of relics functioning as competitive endogenous RNAs in Poaceae genomes.

  10. [Demographic impact of cesarean section].

    Science.gov (United States)

    Rosales Aujang, Enrique; Felguérez Flores, Jesús Alberto

    2009-08-01

    in the vital statistics the cesarean section is a cause that makes reference to births and deaths. to analyze the frequency of the cesarean section, the changes brought about in the rates of maternal, perinatal mortality and of natality, and their relation with reliable contraceptive methods. retrospective study realized with the dices of patients of the Coordination of Reproductive Health of the Mexican Institute of the Social Insurance (IMSS) of the state of Aguascalientes (Mexico). The births were registered majors of 20 weeks of gestation, the maternal and perinatal deaths from 1990 to 2007 in the hospitals of the IMSS in Aguascalientes. The rate of cesarean calculated by means of the registry of the number of the same realized per year and they were divided between the total of vaginal and abdominal births, and the result multiplied percent. 201,563 obstetrical events were registered, of which 145,106 corresponded to vaginal childbirths and 56,457 abdominal ones. With these data a global rate of cesarean section of 28% was obtained, with 201,182 new born alive ones and 2,618 perinatal ones. The acceptance of the tubary bilateral occlusion maintained a constant increase during the period of study, like the intrauterine device. The acceptance from the bilateral occlusion was completely different tubary during the cesarean one, in comparison with the childbirth. the long term results show positive influence in the reduction of the rate of natality.

  11. Analysis of Static and Dynamic E-Reference Content at a Multi-Campus University Shows, that Updated Content is Associated with Greater Annual Usage

    Directory of Open Access Journals (Sweden)

    Laura Costello

    2016-03-01

    Full Text Available Objective – To discover whether there is a difference in use over time between dynamically updated and changing subscription e-reference titles and collections, and static purchased e-reference titles and collections. Design – Case study. Setting – A multi-campus Canadian university with 9,200 students enrolled in both graduate and undergraduate programs. Subjects – E-reference book packages and individual e-reference titles. Methods – The author compared data from individual e-reference books and packages. First, individual subscription e-reference books that periodically added updated content were compared to individually purchased e-reference books that remained static after purchase. The author then compared two e-reference book packages that provided new and updated content to two static e-reference book packages. The author compared data from patron usage to new content added over time using regression analysis. Main Results – As the library acquired e-reference titles, dynamic title subscriptions added to the collection were associated with 2,246 to 4,635 views per subscription while static title additions were associated with 8 to 123 views per purchase. The author also found that there was a strong linear relationship between views and dynamic titles added to the collection (R2=0.79 and a very weak linear relationship (R2=0.18 with views when static titles are added to the collection. Regression analysis of dynamic e-reference collections revealed that the number of titles added to each collection was strongly associated with views of the material (R2=0.99, while static e-reference collections were less strongly linked (R2=0.43. Conclusion – Dynamic e-reference titles and collections experienced increases in usage each year while static titles and collections experienced decreases in usage. This indicates that collections and titles that offer new content to users each year will continue to see growth in usage while static

  12. Citation Analysis Shows Promise as an Effective Tool for Monograph Collection Citation Analysis Shows Promise as an Effective Tool for Monograph Collection Development. A Review of: Enger, K. B. (2009. Using citation analysis to develop core book collections in academic libraries. Library & Information Science Research, 31(2, 107‐112.

    Directory of Open Access Journals (Sweden)

    Scott Marsalis

    2010-06-01

    Full Text Available Objective – To test whether acquiring books written by authors of highly cited journal articles is an effective method for building a collection in the social sciences.Design – Comparison Study.Setting – Academic library at a public university in the US.Subjects – A total of 1,359 book titles, selected by traditional means (n=1,267 or based on citation analysis (n=92.Methods – The researchers identified highly‐ranked authors, defined as the most frequently cited authors publishing in journals with an impact factor greater than one, with no more than six journals in any category, using 1999 ISI data. They included authors in the categories Business, Anthropology, Criminology & Penology, Education & Education Research, Political Science, Psychology, Sociology/Anthropology, and General Social Sciences. The Books in Print bibliographic tool was searched to identify monographs published by these authors, and any titles not already owned were purchased. All books in the study were available to patrons by Fall 2005. The researchers collected circulation data in Spring 2007, and used it to compare titles acquired by this method with titles selected by traditional means.Main Results – Overall, books selected by traditional methods circulated more than those selected by citation analysis, with differences significant at the .001 level. However, at the subject category level, there was no significant difference at the .05 level. Most books selected by the test method circulated one to two times.Conclusion – Citation analysis can be an effective method for building a relevant book collection, and may be especially effective for identifying works relevant to a discipline beyond local context.

  13. Prediction of Individual Social-Demographic Role Based on Travel Behavior Variability Using Long-Term GPS Data

    Directory of Open Access Journals (Sweden)

    Lei Zhu

    2017-01-01

    Full Text Available With the development of and advances in smartphones and global positioning system (GPS devices, travelers’ long-term travel behaviors are not impossible to obtain. This study investigates the pattern of individual travel behavior and its correlation with social-demographic features. For different social-demographic groups (e.g., full-time employees and students, the individual travel behavior may have specific temporal-spatial-mobile constraints. The study first extracts the home-based tours, including Home-to-Home and Home-to-Non-Home, from long-term raw GPS data. The travel behavior pattern is then delineated by home-based tour features, such as departure time, destination location entropy, travel time, and driving time ratio. The travel behavior variability describes the variances of travelers’ activity behavior features for an extended period. After that, the variability pattern of an individual’s travel behavior is used for estimating the individual’s social-demographic information, such as social-demographic role, by a supervised learning approach, support vector machine. In this study, a long-term (18-month recorded GPS data set from Puget Sound Regional Council is used. The experiment’s result is very promising. The sensitivity analysis shows that as the number of tours thresholds increases, the variability of most travel behavior features converges, while the prediction performance may not change for the fixed test data.

  14. Prediction of Individual Social-Demographic Role Based on Travel Behavior Variability Using Long-Term GPS Data

    Energy Technology Data Exchange (ETDEWEB)

    Zhu, Lei [Transportation and Hydrogen Systems Center, National Renewable Energy Laboratory (NREL), 15013 Denver West Parkway, Golden, CO 80401, USA; Gonder, Jeffrey [Transportation and Hydrogen Systems Center, National Renewable Energy Laboratory (NREL), 15013 Denver West Parkway, Golden, CO 80401, USA; Lin, Lei [Department of Civil, Structural and Environmental Engineering, University at Buffalo, Buffalo, NY 14260, USA

    2017-01-01

    With the development of and advances in smartphones and global positioning system (GPS) devices, travelers’ long-term travel behaviors are not impossible to obtain. This study investigates the pattern of individual travel behavior and its correlation with social-demographic features. For different social-demographic groups (e.g., full-time employees and students), the individual travel behavior may have specific temporal-spatial-mobile constraints. The study first extracts the home-based tours, including Home-to-Home and Home-to-Non-Home, from long-term raw GPS data. The travel behavior pattern is then delineated by home-based tour features, such as departure time, destination location entropy, travel time, and driving time ratio. The travel behavior variability describes the variances of travelers’ activity behavior features for an extended period. After that, the variability pattern of an individual’s travel behavior is used for estimating the individual’s social-demographic information, such as social-demographic role, by a supervised learning approach, support vector machine. In this study, a long-term (18-month) recorded GPS data set from Puget Sound Regional Council is used. The experiment’s result is very promising. The sensitivity analysis shows that as the number of tours thresholds increases, the variability of most travel behavior features converges, while the prediction performance may not change for the fixed test data.

  15. Single-cell analysis shows that paracrine signaling by first responder cells shapes the interferon-β response to viral infection.

    Science.gov (United States)

    Patil, Sonali; Fribourg, Miguel; Ge, Yongchao; Batish, Mona; Tyagi, Sanjay; Hayot, Fernand; Sealfon, Stuart C

    2015-02-10

    Immune responses to viral infection are stochastic processes, which initiate in a limited number of cells that then propagate the response. A key component of the response to viral infection entails the synthesis and secretion of type I interferons (IFNs), including the early induction of the gene encoding IFN-β (Ifnb1). With single-cell analysis and mathematical modeling, we investigated the mechanisms underlying how increases in the amount of Ifnb1 mRNA per cell and in the numbers of cells expressing Ifnb1 calibrate the response to viral infection. We used single-cell, single-molecule assays to quantify the early induction of Ifnb1 expression (the Ifnb1 response) in human monocyte-derived dendritic cells infected with Newcastle disease virus, thus retaining the physiological stoichiometry of transcriptional regulators to both alleles of the Ifnb1 gene. We applied computational methods to extract the stochastic features that underlie the cell-to-cell variations in gene expression over time. Integration of simulations and experiments identified the role of paracrine signaling in increasing the number of cells that express Ifnb1 over time and in calibrating the immune response to viral infection. Copyright © 2015, American Association for the Advancement of Science.

  16. Analysis of Status and Socio-demographic Influencing Factors on Doctor's Occupational Well-being in Beijing%北京市医生职业幸福感现况及社会人口学因素分析

    Institute of Scientific and Technical Information of China (English)

    刘婷; 张曼华; 刘颖; 马妮娜; 朱洁

    2015-01-01

    目的:了解北京市医生的职业幸福感现况及社会人口学因素对职业幸福感的影响。方法:采用分层抽样的方法,从一级(社区卫生服务中心)、二级、三级医院在编医生中按照人数1:1:1随机选取1465人进行问卷调查。结果:医生情感幸福感得分(3.59±0.93)分,认知幸福感(4.16±0.78)分。不同工作年限、科室类别、休息时间的医生职业幸福感存在显著性差异。多元线性回归分析表明,情感幸福感的保护性影响因素为临床专科、医技科室。认知幸福感的保护性因素为正高级职称、临床专科;医生职业幸福感危险性因素主要为休息时间一天、工作年限11-15年。结论:北京而医生职业幸福感水平中等偏低,需要加强对中年人群、低职称、内外科医生的职业幸福感的关注和提升。%Objective To study the status of doctors'occupational well-being in Beijing and analyze the socio-demographic factors on occu-pational well-being.Methods Stratified random sampling method;was used the 1465 respondents were selected according to the proportion of 1:1:1 from 29 hospitals including community health service centers, Two-A hospital and Three-A hospital.Results The score of doctors'affective well-being was 3.59 ±0.93,and Cognitive well-being was 4.16 ±0.78.The differences on occupational well-being score of doctors who were different work seniority, department and rest time were statistically significant.Multiple linear regression analysis indicated that the protective fac-tors for affective well-being were clinical specialty and medical laboratory.The protective factors for cognitive well-being were the senior title and clinical specialty.The risk factors of occupational well-being were mainly one-day rest time and wok seniority of 11-15 years.Conclu-sion Occupational well-being of doctors is medium-low level.It needs to pay attention to improve the occupational

  17. Demographic and Related Determinants of Recent Cuban Emigration.

    Science.gov (United States)

    Briquets, Sergio Diaz

    1983-01-01

    Examines principal demographic determinants of recent Cuban emigration and discusses how these demographic variables interact with other social, economic, and political determinants. Suggests that Cuban labor migration is more responsive to demographic factors than some theorists assume. (Author/MJL)

  18. Pregnancy intention, demographic differences, and psychosocial health.

    Science.gov (United States)

    Maxson, Pamela; Miranda, Marie Lynn

    2011-08-01

    We explore the psychosocial, demographic, and maternal characteristics across wanted, mistimed, and unwanted pregnancies. Data from 1321 women from a prospective cohort study of pregnant women in Durham, NC, are analyzed. Psychosocial correlates were obtained through prenatal surveys; electronic medical records were used to ascertain maternal health and pregnancy outcomes. Sixty-two percent of the women indicated an unintended pregnancy, with 44% (578) mistimed and 18% (245) unwanted. Only 38% of the pregnancies were characterized as wanted. Women with unwanted and with mistimed pregnancies were similar demographically, but they differed significantly on psychosocial profiles and maternal characteristics. Women with mistimed and with wanted pregnancies differed in demographics and psychosocial profiles. Wanted pregnancies had the healthiest, mistimed an intermediate, and unwanted the poorest psychosocial profile. Women with unwanted pregnancies had the highest depression, perceived stress, and negative paternal support scores (ppsychosocial profiles had higher odds of being in the unwanted category. Controlling for psychosocial and demographic variables, perceived stress and positive paternal support remained significant predictors of belonging to the unwanted and mistimed groups. Fully characterizing pregnancy intention and its relationship to psychosocial profiles may provide a basis for identifying women with highest risk during pregnancy and early motherhood. Women with unwanted and mistimed pregnancies may appear similar demographically but are different psychosocially. Women with unwanted pregnancies have multiple risk factors and would benefit from targeted interventions.

  19. Program impact pathway analysis of a social franchise model shows potential to improve infant and young child feeding practices in Vietnam.

    Science.gov (United States)

    Nguyen, Phuong H; Menon, Purnima; Keithly, Sarah C; Kim, Sunny S; Hajeebhoy, Nemat; Tran, Lan M; Ruel, Marie T; Rawat, Rahul

    2014-10-01

    By mapping the mechanisms through which interventions are expected to achieve impact, program impact pathway (PIP) analysis lays out the theoretical causal links between program activities, outcomes, and impacts. This study examines the pathways through which the Alive & Thrive (A&T) social franchise model is intended to improve infant and young child feeding (IYCF) practices in Vietnam. Mixed methods were used, including qualitative interviews with franchise management board members (n = 12), surveys with health providers (n = 120), counseling observations (n = 160), and household surveys (n = 2045). Six PIP components were assessed: 1) franchise management, 2) training and IYCF knowledge of health providers, 3) service delivery, 4) program exposure and utilization, 5) maternal behavioral determinants (knowledge, beliefs, and intentions) toward optimal IYCF practices, and 6) IYCF practices. Data were collected from A&T-intensive areas (A&T-I; mass media + social franchise) and A&T-nonintensive areas (A&T-NI; mass media only) by using a cluster-randomized controlled trial design. Data from 2013 were compared with baseline where similar measures were available. Results indicate that mechanisms are in place for effective management of the franchise system, despite challenges to routine monitoring. A&T training was associated with increased capacity of providers, resulting in higher-quality IYCF counseling (greater technical knowledge and communication skills during counseling) in A&T-I areas. Franchise utilization increased from 10% in 2012 to 45% in 2013 but fell below the expected frequency of 9-15 contacts per mother-child dyad. Improvements in breastfeeding knowledge, beliefs, intentions, and practices were greater among mothers in A&T-I areas than among those in A&T-NI areas. In conclusion, there are many positive changes along the impact pathway of the franchise services, but challenges in utilization and demand creation should be addressed to achieve the full

  20. Comprehensive Behavioral Analysis of Male Ox1r (-/-) Mice Showed Implication of Orexin Receptor-1 in Mood, Anxiety, and Social Behavior.

    Science.gov (United States)

    Abbas, Md G; Shoji, Hirotaka; Soya, Shingo; Hondo, Mari; Miyakawa, Tsuyoshi; Sakurai, Takeshi

    2015-01-01

    Neuropeptides orexin A and orexin B, which are exclusively produced by neurons in the lateral hypothalamic area, play an important role in the regulation of a wide range of behaviors and homeostatic processes, including regulation of sleep/wakefulness states and energy homeostasis. The orexin system has close anatomical and functional relationships with systems that regulate the autonomic nervous system, emotion, mood, the reward system, and sleep/wakefulness states. Recent pharmacological studies using selective antagonists have suggested that orexin receptor-1 (OX1R) is involved in physiological processes that regulate emotion, the reward system, and autonomic nervous system. Here, we examined Ox1r (-/-) mice with a comprehensive behavioral test battery to screen additional OX1R functions. Ox1r (-/-) mice showed increased anxiety-like behavior, altered depression-like behavior, slightly decreased spontaneous locomotor activity, reduced social interaction, increased startle response, and decreased prepulse inhibition. These results suggest that OX1R plays roles in social behavior and sensory motor gating in addition to roles in mood and anxiety.

  1. Comprehensive Behavioral Analysis of Male Ox1r−/− Mice Showed Implication of Orexin Receptor-1 in Mood, Anxiety, and Social Behavior

    Science.gov (United States)

    Abbas, Md. G.; Shoji, Hirotaka; Soya, Shingo; Hondo, Mari; Miyakawa, Tsuyoshi; Sakurai, Takeshi

    2015-01-01

    Neuropeptides orexin A and orexin B, which are exclusively produced by neurons in the lateral hypothalamic area, play an important role in the regulation of a wide range of behaviors and homeostatic processes, including regulation of sleep/wakefulness states and energy homeostasis. The orexin system has close anatomical and functional relationships with systems that regulate the autonomic nervous system, emotion, mood, the reward system, and sleep/wakefulness states. Recent pharmacological studies using selective antagonists have suggested that orexin receptor-1 (OX1R) is involved in physiological processes that regulate emotion, the reward system, and autonomic nervous system. Here, we examined Ox1r−/− mice with a comprehensive behavioral test battery to screen additional OX1R functions. Ox1r−/− mice showed increased anxiety-like behavior, altered depression-like behavior, slightly decreased spontaneous locomotor activity, reduced social interaction, increased startle response, and decreased prepulse inhibition. These results suggest that OX1R plays roles in social behavior and sensory motor gating in addition to roles in mood and anxiety. PMID:26696848

  2. Analysis of ORFs 2b, 3, 4, and partial ORF5 of sequential isolates of equine arteritis virus shows genetic variation following experimental infection of horses.

    Science.gov (United States)

    Liu, Lihong; Castillo-Olivares, Javier; Davis-Poynter, Nick J; Baule, Claudia; Xia, Hongyan; Belák, Sándor

    2008-06-22

    Samples from horses experimentally infected with the "large plaque variant (LP3A+)" of equine arteritis virus were analysed. These included 182 nasal swabs collected from day 1 to 14 post-infection (p.i.), and 21 virus isolates obtained from white blood cells of animals that showed a prolonged viraemia between days 30 to 72 p.i. In order to determine the genetic stability of the virus and particularly to characterise the genetic variants found during the prolonged viraemia, partial sequences of open reading frame 5 (ORF5) encoding glycoprotein 5 (GP5) were generated. Viruses with amino acid substitutions in GP5 were used for further amplification and sequencing of a fragment encompassing ORFs 2b, 3, and 4. The ORF5 nucleotide sequences of the virus present in 65 out of 66 nasal swabs were identical to that of the inoculated virus, suggesting that the ORF5 gene of LP3A+ was genetically stable during the first 2 weeks p.i. Contrary to this, a number of mutations were found in the ORF5 of virus isolates obtained from day 30 p.i. The mutations mainly clustered in antigenic neutralization site C within variable region 1 of the GP5 ectodomain. Sequence variability was also identified in ORFs 2b, 3 and 4, with ORF 4 having the highest proportion of non-synonymous changes (4/6).

  3. Development of a software for computer-linguistic verification of socio-demographic profile of web-community member

    OpenAIRE

    Solomia Fedushko

    2014-01-01

    This article considers the current important scientific and applied problem of socio-demographic characteristics validation of virtual community members by computer-linguistic analysis of web-community members' information track. A systematic analysis of the web-members information content and the research of the web-communication specificity of each socio-demographic characteristics value by virtual community content validation for further modeling socio-demographic profiles of web-members a...

  4. Demographic tensions in Central America.

    Science.gov (United States)

    1986-08-01

    This discussion of Central America focuses on the rapid growth of its population, its stagnating economy, and those countries that are socioeconomically advanced. Between 1950-85 the population of Central America tripled, from 9.1 million to 26. 4 million, due to marked mortality declines and the absence of off-setting fertility declines. The distribution of Central Americas's growing populations sets its population growth apart from that of other developing regions. Currently, almost half of all Central Americans live in cities. Although the average growth rate for Central American countries has fallen and is expected to drop further, the decline does not counterbalance the effect of the absolute rise in population numbers. The average annual growth rate of more than 3% annually in the 1960s fell to about 2.6% in recent years, but this decline is due primarily to socioeconomically advanced Costa Rica and Panama. Central America's age structure further complicates the population crisis. About 43% of Central Americans are under the age of 15. When the increasingly larger young population group enters it reproductive years, the potential for future growth (albeit the falling rate of population increase) is unparalleled. UN population projections show the region's population at 40 million by the year 2000. The 1973 oil crisis began a downward spiral for the buoyant post World War II Central American economy. Between 1950-79, real per capita income growth in Central America doubled, with Central American economies growing an average of 5.3% annually. By the early 1980s, overseas markets of the trade-dependent countries of Central America had dried up due to protectionism abroad and slumping basic commodity prices. These and other factors plunged Central America into its current economic malaise of falling real per capita income, rising unemployment, curtailed export led economic growth, and a rising cost of living. In general, economic growth in Central America

  5. Retrotransposon-centered analysis of piRNA targeting shows a shift from active to passive retrotransposon transcription in developing mouse testes

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    Mourier Tobias

    2011-09-01

    Full Text Available Abstract Background Piwi-associated RNAs (piRNAs bind transcripts from retrotransposable elements (RTE in mouse germline cells and seemingly act as guides for genomic methylation, thereby repressing the activity of RTEs. It is currently unknown if and how Piwi proteins distinguish RTE transcripts from other cellular RNAs. During germline development, the main target of piRNAs switch between different types of RTEs. Using the piRNA targeting of RTEs as an indicator of RTE activity, and considering the entire population of genomic RTE loci along with their age and location, this study aims at further elucidating the dynamics of RTE activity during mouse germline development. Results Due to the inherent sequence redundancy between RTE loci, assigning piRNA targeting to specific loci is problematic. This limits the analysis, although certain features of piRNA targeting of RTE loci are apparent. As expected, young RTEs display a much higher level of piRNA targeting than old RTEs. Further, irrespective of age, RTE loci near protein-coding coding genes are targeted to a greater extent than RTE loci far from genes. During development, a shift in piRNA targeting is observed, with a clear increase in the relative piRNA targeting of RTEs residing within boundaries of protein-coding gene transcripts. Conclusions Reanalyzing published piRNA sequences and taking into account the features of individual RTE loci provide novel insight into the activity of RTEs during development. The obtained results are consistent with some degree of proportionality between what transcripts become substrates for Piwi protein complexes and the level by which the transcripts are present in the cell. A transition from active transcription of RTEs to passive co-transcription of RTE sequences residing within protein-coding transcripts appears to take place in postnatal development. Hence, the previously reported increase in piRNA targeting of SINEs in postnatal testis development

  6. High Content Analysis of Hippocampal Neuron-Astrocyte Co-cultures Shows a Positive Effect of Fortasyn Connect on Neuronal Survival and Postsynaptic Maturation

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    Anne-Lieke F. van Deijk

    2017-08-01

    Full Text Available Neuronal and synaptic membranes are composed of a phospholipid bilayer. Supplementation with dietary precursors for phospholipid synthesis –docosahexaenoic acid (DHA, uridine and choline– has been shown to increase neurite outgrowth and synaptogenesis both in vivo and in vitro. A role for multi-nutrient intervention with specific precursors and cofactors has recently emerged in early Alzheimer's disease, which is characterized by decreased synapse numbers in the hippocampus. Moreover, the medical food Souvenaid, containing the specific nutrient combination Fortasyn Connect (FC, improves memory performance in early Alzheimer's disease patients, possibly via maintaining brain connectivity. This suggests an effect of FC on synapses, but the underlying cellular mechanism is not fully understood. Therefore, we investigated the effect of FC (consisting of DHA, eicosapentaenoic acid (EPA, uridine, choline, phospholipids, folic acid, vitamins B12, B6, C and E, and selenium, on synaptogenesis by supplementing it to primary neuron-astrocyte co-cultures, a cellular model that mimics metabolic dependencies in the brain. We measured neuronal developmental processes using high content screening in an automated manner, including neuronal survival, neurite morphology, as well as the formation and maturation of synapses. Here, we show that FC supplementation resulted in increased numbers of neurons without affecting astrocyte number. Furthermore, FC increased postsynaptic PSD95 levels in both immature and mature synapses. These findings suggest that supplementation with FC to neuron-astrocyte co-cultures increased both neuronal survival and the maturation of postsynaptic terminals, which might aid the functional interpretation of FC-based intervention strategies in neurological diseases characterized by neuronal loss and impaired synaptic functioning.

  7. Motor neuron diseases in the University Hospital of Fortaleza (Northeastern Brazil: a clinico-demographic analysis of 87 cases Doenças do neurônio motor no Hospital Universitário de Fortaleza (Nordeste do Brasil: análise clínico-demográfica de 87 casos

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    CARLOS M. DE CASTRO-COSTA

    2000-12-01

    Full Text Available In this retrospective (1980-1998 study, we have analyzed clinico-demographically, from the records of the University Hospital of Fortaleza (Brazil, a group of 87 patients showing signs and symptoms of motor neuron diseases (MNDs. Their diagnosis was determined clinically and laboratorially. The WFN criteria were used for amyotrophic lateral sclerosis (ALS diagnosis. The clinico-demographic analysis of the 87 cases of MNDs showed that 4 were diagnosed as spinal muscular atrophy (SMA, 5 cases as ALS subsets: 2 as progressive bulbar paralysis (PBP, 2 as progressive muscular atrophy (PMA and 1 as monomelic amyotrophy (MA, and 78 cases of ALS. The latter comprised 51 males and 27 females, with a mean age of 42.02 years. They were sub-divided into 4 groups according to age: from 15 to 29 years (n= 17, 30 to 39 years (n= 18, 40 to 69 years (n= 39 and 70 to 78 years (n= 4. From the 78 ALS patients, 76 were of the classic sporadic form whilst only 2 were of the familial form. The analysis of the 87 patients with MNDs from the University Hospital of Fortaleza showed a predominance of ALS patients, with a high number of cases of juvenile and early onset adult sporadic ALS.Neste estudo retrospectivo (1980-1998, analisamos clínico-demograficamente, a partir dos prontuários do Hospital Universitário de Fortaleza (Brasil, um grupo de 87 pacientes que apresentavam sinais e sintomas de doenças do neurônio motor (DNMs. Eles foram diagnosticados clinicamente, e através de exames complementares. Para o diagnóstico da esclerose lateral amiotrófica (ELA, usamos os critérios da Federação Mundial de Neurologia. A análise clínico-demográfica dos 87 casos de DNMs evidenciou a existência de 4 casos de atrofia muscular espinhal (AME, 5 casos de variantes da ELA: 2 de paralisia bulbar progressiva (PBP, 2 de atrofia muscular progressiva (AMP e 1 de amiotrofia monomélica (AM, e 78 casos de ELA. Esses últimos eram constituídos de 51 homens e 27 mulheres, com

  8. Febrile Seizure: Demographic Features and Causative Factors

    OpenAIRE

    2012-01-01

    How to cite this article: Esmaili Gourabi H, Bidabadi E, Cheraghalipour  F, Aarabi  Y, Salamat F. Febrile Seizure: Demographic Features and Causative Factors. Iran J Child Neurol Autumn 2012; 6(4):33-37.Abstract Objective Because of geographical and periodical variation, we prompted to determine the demographic features and causative factors for febrile seizure in Rasht. Materials & Methods In this cross-sectional study, all 6–month- to 6-year-old children with the diagnosis of febrile s...

  9. Surviving the Holocaust: Socio-demographic Differences Among Amsterdam Jews.

    Science.gov (United States)

    Tammes, Peter

    2017-01-01

    This study determined the victimisation rate among Amsterdam Jews and socio-demographic differences in surviving the Holocaust. After linking a registration list of over 77,000 Jewish inhabitants in 1941 to post-war lists of Jewish victims and survivors, the victimisation rate lies between 74.3 and 75.3 %. Differences in survival chances and risk of being killed are examined by using multivariable logistic and Cox regression analyses. While male Jews had a reduced risk of death, in the end their survival chances hardly differed from females. Though Jews aged 6-14 and 31-50 initially had a lower risk of death, in the end compared with Jews aged 15-30 they had lower survival chances, just as Jews aged 50+. For Jews aged 0-5, it was the other way around. Immigrants showed better survival chances than native Jews. German Jews showed better survival chances than Dutch Jews, but Polish and other Jewish nationals showed highest survival chances. Jews who had abandoned Judaism had better survival chances than Jews belonging to an Israelite congregation. Divorced, widowed and unmarried adult Jews had better survival chances than married Jews and their children; Jews married to non-Jews, however, had one of the highest survival chances. Jews in the two highest social classes had better survival chances than jobless Jews. These findings indicate that survival was not random but related to socio-demographic characteristics. This sheds light on demographic consequences of conflict and violence: Nazi persecution reduced the Amsterdam Jewish community drastically, and socio-demographic differences in survival impacted the post-war Jewish population structure.

  10. Socio-economic and demographic determinants of childhood anemia

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    Sankar Goswmai

    2015-10-01

    Full Text Available ABSTRACT OBJECTIVE: To evaluate socio-economic and demographic determinants of anemia among Indian children aged 6-59 months. METHODS: Statistical analysis was performed on the cross-sectional weighted sample of 40,885 children from 2005 to 2006 National Family Health Survey by using multinomial logistic regression to assess the significance of some risk factors in different degrees of child anemia. Anemia was diagnosed by World Health Organization (WHO cut-off points on hemoglobin level. Pearson's chi-squared test was applied to justify the associations of anemia with different categories of the study population. RESULTS: The prevalence of anemia was 69.5%; 26.2% mild, 40.4% moderate, and 2.9% severe anemia. Overall prevalence rate, along with mild and moderate cases, showed an increasing trend up to 2 years of age and then decreased. Rural children had a higher prevalence rate. Of 28 Indian states in the study, 10 states showed very high prevalence, the highest being Bihar (77.9%. Higher birth order, high index of poverty, low level of maternal education, mother's anemia, non-intake of iron supplements during pregnancy, and vegetarian mother increased the risks of all types of anemia among children (p < 0.05. Christian population was at lower risk; and Scheduled Caste, Scheduled Tribe, and Other Backward Class categories were at higher risk of anemia. CONCLUSION: The results suggest a need for proper planning and implementation of preventive measures to combat child anemia. Economically under-privileged groups, maternal nutrition and education, and birth control measures should be priorities in the programs.

  11. Psychosocial and demographic predictors of pediatric psychotropic medication use.

    Science.gov (United States)

    Hong, S H; Shepherd, M D

    1996-08-15

    The effects of age, gender, and family background on children's use of prescription psychoactive medications were studied. Patient and prescribing information was obtained for children enrolled as dependents in any of five prescription drug benefit plans during the period from December 29, 1992, through December 28, 1993. A binary response model was specified under the assumption of logistic distribution of probabilities of psychotropic drug use. The independent variables were family size, parenting type (single- or two-parent family), parental use of psychotropic medications, and child's age, gender, and the interaction between age and gender. Logistic regression analysis was conducted not only for overall psychotropic drug use but also for antidepressants, antianxiety drugs, and CNS stimulants. The sample included 3144 children; 3.9% received psychotropic drugs. Family size and parenting type had no effect on overall use of psychotropic drugs by children, but children were more likely to receive psychotropic drugs if the parents took them. The study showed an interaction between age and gender. At younger ages, boys were more likely than girls to receive psychotropic drugs; the opposite was true at older ages. For particular subcategories of drugs the study showed that (1) boys were more likely than girls, and young children were more likely than older children, to receive CNS stimulants, (2) children from single-parent families were less likely to use antidepressants than children from two-parent households, and (3) the influence of mothers' psychotropic drug use extended to all three drug classes, but the influence of fathers' psychotropic drug use existed for antidepressants only. The effects of demographic and familial factors on children's use of psychotropic drugs varied according to the drug class.

  12. Fast demographic traits promote high diversification rates of Amazonian trees

    Science.gov (United States)

    Baker, Timothy R; Pennington, R Toby; Magallon, Susana; Gloor, Emanuel; Laurance, William F; Alexiades, Miguel; Alvarez, Esteban; Araujo, Alejandro; Arets, Eric J M M; Aymard, Gerardo; de Oliveira, Atila Alves; Amaral, Iêda; Arroyo, Luzmila; Bonal, Damien; Brienen, Roel J W; Chave, Jerome; Dexter, Kyle G; Di Fiore, Anthony; Eler, Eduardo; Feldpausch, Ted R; Ferreira, Leandro; Lopez-Gonzalez, Gabriela; van der Heijden, Geertje; Higuchi, Niro; Honorio, Eurídice; Huamantupa, Isau; Killeen, Tim J; Laurance, Susan; Leaño, Claudio; Lewis, Simon L; Malhi, Yadvinder; Marimon, Beatriz Schwantes; Marimon Junior, Ben Hur; Monteagudo Mendoza, Abel; Neill, David; Peñuela-Mora, Maria Cristina; Pitman, Nigel; Prieto, Adriana; Quesada, Carlos A; Ramírez, Fredy; Ramírez Angulo, Hirma; Rudas, Agustin; Ruschel, Ademir R; Salomão, Rafael P; de Andrade, Ana Segalin; Silva, J Natalino M; Silveira, Marcos; Simon, Marcelo F; Spironello, Wilson; ter Steege, Hans; Terborgh, John; Toledo, Marisol; Torres-Lezama, Armando; Vasquez, Rodolfo; Vieira, Ima Célia Guimarães; Vilanova, Emilio; Vos, Vincent A; Phillips, Oliver L; Wiens, John

    2014-01-01

    The Amazon rain forest sustains the world's highest tree diversity, but it remains unclear why some clades of trees are hyperdiverse, whereas others are not. Using dated phylogenies, estimates of current species richness and trait and demographic data from a large network of forest plots, we show that fast demographic traits – short turnover times – are associated with high diversification rates across 51 clades of canopy trees. This relationship is robust to assuming that diversification rates are either constant or decline over time, and occurs in a wide range of Neotropical tree lineages. This finding reveals the crucial role of intrinsic, ecological variation among clades for understanding the origin of the remarkable diversity of Amazonian trees and forests. PMID:24589190

  13. ECONOMIC PROBLEMS OF EUROPEAN UNION CAUSED BY THE DEMOGRAPHIC AGEING

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    Iulia-Alexandra Percă

    2011-09-01

    Full Text Available The purpose of this paper is to offer a realistic perspective upon the imminent situation of demographic ageing issue in European Union. The forecasts are not reasons to major concern for the society but rather to become more responsible and not to neglect a problem that could affect our future. The demographic overview of Europe for 2011 – 2060 shows low birth rates, an increase in life expectancy and migration flows having an impact on population. As a result, the parent generation will no longer completely be replaced by the next generation of children and the narrowed active population will have to sustain a large number of persons far advanced in the age. Economic consequences of this social trend, such as increased expenditures on pensions, extended health care costs and the employment problems, are also discussed in order to define the best policy option available.

  14. Life Potential as a Basic Demographic Indicator

    Science.gov (United States)

    Goerlich, Francisco J.; Soler, Angel

    2013-01-01

    This paper proposes an indicator that integrates life expectancy with the demographic structure of the population for a given society. By doing this, we have a simple indicator of mortality and aging combined, which could be very useful for developed societies. As is widely known, life expectancy at birth is independent of the demographic…

  15. Demographic development in ASEAN: a comparative overview.

    Science.gov (United States)

    Herrin, A N; Pardoko, H; Lim, L L; Hongladorom, C

    1981-01-01

    A comparative overview of recent demographic developments in the ASEAN (Association of Southeast Asian Nations) region is presented. Countries discussed include Indonesia, Malaysia, the Philippines, Singapore, and Thailand. Separate consideration is given to mortality; fertility; and migration, spatial distribution, and employment. A final section is concerned with emerging issues and directions for population policy.

  16. Second demographic transition de-blocked?

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    Bobić Mirjana

    2011-01-01

    Full Text Available The text is re-examining the previously established dilemma related to whether Serbia (without Kosovo and Metohija is the country of second demographic transition, i.e.: has the transition been de-blocked, under the assumption that this is a worldwide historical process of transformation of industrialized countries. The last thesis, around which there exists a lot of controversy in the contemporary population theory, is however not dealt with in detail; to the contrary, it is used as the general theoretical framework for the exploration of the most recent tendencies in the transformation of nuptiality and fertility regime in Serbia, as well as in the western and countries in post-socialist transformation. Special attention is given to the ideational changes, more precisely to the specific features of the value profile of the Serbian population, which is one of the most important determinants of the societal framework, that acts in the back of the afore mentioned aggregate demographic indicators. Finally, the hypothesis is posed (which should be further investigated by means of in-depth research and complementary approach that the speeding-up of the second demographic transition and intensification of the individualisation not only of the partnership but of the parenthood as well, accompanied with the rise of living standard and social support to balancing work and family, would have produced important emancipating and, concomitantly, positive socioeconomic and demographic effects.

  17. The Demographics of Corporal Punishment in Texas

    Science.gov (United States)

    Phillips, Stephanie

    2012-01-01

    This dissertation examined the student discipline policies of 1,025 Texas school districts, as well as data from the Texas Education Agency's Academic Excellence Indicator System in order to identify demographic patterns regarding corporal punishment policies in Texas schools. The study also studied the relationship between a district's…

  18. The Demographics of Corporal Punishment in Texas

    Science.gov (United States)

    Phillips, Stephanie

    2012-01-01

    This dissertation examined the student discipline policies of 1,025 Texas school districts, as well as data from the Texas Education Agency's Academic Excellence Indicator System in order to identify demographic patterns regarding corporal punishment policies in Texas schools. The study also studied the relationship between a district's corporal…

  19. Demographic Group Differences in Adolescents' Time Attitudes

    Science.gov (United States)

    Andretta, James R.; Worrell, Frank C.; Mello, Zena R.; Dixson, Dante D.; Baik, Sharon H.

    2013-01-01

    In the present study, we examined demographic differences in time attitudes in a sample of 293 adolescents. Time attitudes were measured using the Adolescent Time Attitude Scale (Mello & Worrell, 2007; Worrell, Mello, & Buhl, 2011), which assesses positive and negative attitudes toward the past, the present, and the future. Generally, African…

  20. The Macroeconomic Dynamics of Demographic Shocks

    NARCIS (Netherlands)

    Heijdra, B.J.; Ligthart, J.E.

    2004-01-01

    The paper employs an extended Yaari-Blanchard model of overlapping generations to study how the macroeconomy is affected over time by various demographic changes.It is shown that a proportional decline in fertility and death rates has qualitatively similar effects to capital income subsidies; both p

  1. Demographic and audiological factors as predictors of hearing handicap

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    Leposavić Ljubica

    2006-01-01

    Full Text Available INTRODUCTION Currently available evidence reveals comparatively few studies of psychological effects of hearing impairments, in spite of the fact that clinicians have for a long time been aware of a connection between the acquired hearing impairment and mental disorders. They are focused on the investigation of dysfunction in general. Thus, three domains of the auditory imbalance may be distinguished: disorder, disability and handicap. 'Handicap', according to the definition of the World Health Organization, is a hindrance in an individual that results from an impairment or disability and represents psychological response of the individual to the impairment. OBJECTIVE Validation of acquired hearing impairment as a risk factor of psychical disorders as well as an analysis of relation of some demographic factors (sex, age, education and audiological factors (degree and duration of the impairment with the frequency of hearing handicap. METHOD MMPI-201 has been applied in 60 subjects affected with otosclerosis, potential candidates for stapedectomy, before and after the surgery. RESULTS Individuals with acquired hearing impairment manifest more frequent disorders of psychical functioning in comparison with general population, while demographic and audiometric parameters did not correlate with acquired hearing handicap. CONCLUSION It may be assumed that the very recognition of demographic and audio-logical factors can not help much in the understanding of the psychological stress associated with hearing impairment.

  2. Demographic History of Indigenous Populations in Mesoamerica Based on mtDNA Sequence Data.

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    Antonio González-Martín

    Full Text Available The genetic characterization of Native American groups provides insights into their history and demographic events. We sequenced the mitochondrial D-loop region (control region of 520 samples from eight Mexican indigenous groups. In addition to an analysis of the genetic diversity, structure and genetic relationship between 28 Native American populations, we applied Bayesian skyline methodology for a deeper insight into the history of Mesoamerica. AMOVA tests applying cultural, linguistic and geographic criteria were performed. MDS plots showed a central cluster of Oaxaca and Maya populations, whereas those from the North and West were located on the periphery. Demographic reconstruction indicates higher values of the effective number of breeding females (Nef in Central Mesoamerica during the Preclassic period, whereas this pattern moves toward the Classic period for groups in the North and West. Conversely, Nef minimum values are distributed either in the Lithic period (i.e. founder effects or in recent periods (i.e. population declines. The Mesomerican regions showed differences in population fluctuation as indicated by the maximum Inter-Generational Rate (IGRmax: i Center-South from the lithic period until the Preclassic; ii West from the beginning of the Preclassic period until early Classic; iii North characterized by a wide range of temporal variation from the Lithic to the Preclassic. Our findings are consistent with the genetic variations observed between central, South and Southeast Mesoamerica and the North-West region that are related to differences in genetic drift, structure, and temporal survival strategies (agriculture versus hunter-gathering, respectively. Interestingly, although the European contact had a major negative demographic impact, we detect a previous decline in Mesoamerica that had begun a few hundred years before.

  3. Demographic History of Indigenous Populations in Mesoamerica Based on mtDNA Sequence Data

    Science.gov (United States)

    González-Martín, Antonio; Gorostiza, Amaya; Regalado-Liu, Lucía; Arroyo-Peña, Sergio; Tirado, Sergio; Nuño-Arana, Ismael; Rubi-Castellanos, Rodrigo; Sandoval, Karla; Coble, Michael D.; Rangel-Villalobos, Héctor

    2015-01-01

    The genetic characterization of Native American groups provides insights into their history and demographic events. We sequenced the mitochondrial D-loop region (control region) of 520 samples from eight Mexican indigenous groups. In addition to an analysis of the genetic diversity, structure and genetic relationship between 28 Native American populations, we applied Bayesian skyline methodology for a deeper insight into the history of Mesoamerica. AMOVA tests applying cultural, linguistic and geographic criteria were performed. MDS plots showed a central cluster of Oaxaca and Maya populations, whereas those from the North and West were located on the periphery. Demographic reconstruction indicates higher values of the effective number of breeding females (Nef) in Central Mesoamerica during the Preclassic period, whereas this pattern moves toward the Classic period for groups in the North and West. Conversely, Nef minimum values are distributed either in the Lithic period (i.e. founder effects) or in recent periods (i.e. population declines). The Mesomerican regions showed differences in population fluctuation as indicated by the maximum Inter-Generational Rate (IGRmax): i) Center-South from the lithic period until the Preclassic; ii) West from the beginning of the Preclassic period until early Classic; iii) North characterized by a wide range of temporal variation from the Lithic to the Preclassic. Our findings are consistent with the genetic variations observed between central, South and Southeast Mesoamerica and the North-West region that are related to differences in genetic drift, structure, and temporal survival strategies (agriculture versus hunter-gathering, respectively). Interestingly, although the European contact had a major negative demographic impact, we detect a previous decline in Mesoamerica that had begun a few hundred years before. PMID:26292226

  4. Demographic History of Indigenous Populations in Mesoamerica Based on mtDNA Sequence Data.

    Science.gov (United States)

    González-Martín, Antonio; Gorostiza, Amaya; Regalado-Liu, Lucía; Arroyo-Peña, Sergio; Tirado, Sergio; Nuño-Arana, Ismael; Rubi-Castellanos, Rodrigo; Sandoval, Karla; Coble, Michael D; Rangel-Villalobos, Héctor

    2015-01-01

    The genetic characterization of Native American groups provides insights into their history and demographic events. We sequenced the mitochondrial D-loop region (control region) of 520 samples from eight Mexican indigenous groups. In addition to an analysis of the genetic diversity, structure and genetic relationship between 28 Native American populations, we applied Bayesian skyline methodology for a deeper insight into the history of Mesoamerica. AMOVA tests applying cultural, linguistic and geographic criteria were performed. MDS plots showed a central cluster of Oaxaca and Maya populations, whereas those from the North and West were located on the periphery. Demographic reconstruction indicates higher values of the effective number of breeding females (Nef) in Central Mesoamerica during the Preclassic period, whereas this pattern moves toward the Classic period for groups in the North and West. Conversely, Nef minimum values are distributed either in the Lithic period (i.e. founder effects) or in recent periods (i.e. population declines). The Mesomerican regions showed differences in population fluctuation as indicated by the maximum Inter-Generational Rate (IGRmax): i) Center-South from the lithic period until the Preclassic; ii) West from the beginning of the Preclassic period until early Classic; iii) North characterized by a wide range of temporal variation from the Lithic to the Preclassic. Our findings are consistent with the genetic variations observed between central, South and Southeast Mesoamerica and the North-West region that are related to differences in genetic drift, structure, and temporal survival strategies (agriculture versus hunter-gathering, respectively). Interestingly, although the European contact had a major negative demographic impact, we detect a previous decline in Mesoamerica that had begun a few hundred years before.

  5. Influence of harvesting pressure on demographic tactics: Implications for wildlife management

    Science.gov (United States)

    Servanty, S.; Gaillard, J.-M.; Ronchi, F.; Focardi, S.; Baubet, E.; Gimenez, O.

    2011-01-01

    Demographic tactics within animal populations are shaped by selective pressures. Exploitation exerts additional pressures so that differing demographic tactics might be expected among populations with differences in levels of exploitation. Yet little has been done so far to assess the possible consequences of exploitation on the demographic tactics of mammals, even though such information could influence the choice of effective management strategies. Compared with similar-sized ungulate species, wild boar Sus scrofa has high reproductive capabilities, which complicates population management. Using a perturbation analysis, we investigated how population growth rates (??) and critical life-history stages differed between two wild boar populations monitored for several years, one of which was heavily harvested and the other lightly harvested. Asymptotic ?? was 1??242 in the lightly hunted population and 1??115 in the heavily hunted population, while the ratio between the elasticity of adult survival and juvenile survival was 2??63 and 1??27, respectively. A comparative analysis including 21 other ungulate species showed that the elasticity ratio in the heavily hunted population was the lowest ever observed. Compared with expected generation times of similar-sized ungulates (more than 6years), wild boar has a fast life-history speed, especially when facing high hunting pressure. This is well illustrated by our results, where generation times were 3??6years in the lightly hunted population and only 2??3years in the heavily hunted population. High human-induced mortality combined with non-limiting food resources accounted for the accelerated life history of the hunted population because of earlier reproduction. Synthesis and applications. For wild boar, we show that when a population is facing a high hunting pressure, increasing the mortality in only one age-class (e.g. adults or juveniles) may not allow managers to limit population growth. We suggest that simulations of

  6. Demographic and psychological correlates of New Zealanders support for euthanasia.

    Science.gov (United States)

    Lee, Carol Hj; Duck, Isabelle M; Sibley, Chris G

    2017-01-13

    To explore the distribution of New Zealanders' support towards the legalisation of euthanasia and examine demographic and psychological factors associated with these attitudes. 15,822 participants responded to the 2014/15 New Zealand Attitudes and Values Study (NZAVS) survey. This survey included an item on people's attitudes towards euthanasia, and information on their demographic and psychological characteristics. The majority of New Zealanders expressed support for euthanasia, which was assessed by asking "Suppose a person has a painful incurable disease. Do you think that doctors should be allowed by law to end the patient's life if the patient requests it?" Non-religious, liberal, younger, employed, non-parents and those living in rural areas were more supportive. Those of Pacific or Asian ethnicity, with lower income and higher deprivation, education and socio-economic status were less supportive. Furthermore, those high on extraversion, conscientiousness and neuroticism showed more support, while those high on agreeableness and honesty-humility exhibited less support. There is strong public support for euthanasia when people are asked whether doctors should be allowed by law to end the life of a patient with a painful incurable disease upon their request. There are reliable demographic and personality differences in support for euthanasia.

  7. Inferring Demographic History Using Two-Locus Statistics.

    Science.gov (United States)

    Ragsdale, Aaron P; Gutenkunst, Ryan N

    2017-06-01

    Population demographic history may be learned from contemporary genetic variation data. Methods based on aggregating the statistics of many single loci into an allele frequency spectrum (AFS) have proven powerful, but such methods ignore potentially informative patterns of linkage disequilibrium (LD) between neighboring loci. To leverage such patterns, we developed a composite-likelihood framework for inferring demographic history from aggregated statistics of pairs of loci. Using this framework, we show that two-locus statistics are more sensitive to demographic history than single-locus statistics such as the AFS. In particular, two-locus statistics escape the notorious confounding of depth and duration of a bottleneck, and they provide a means to estimate effective population size based on the recombination rather than mutation rate. We applied our approach to a Zambian population of Drosophila melanogaster Notably, using both single- and two-locus statistics, we inferred a substantially lower ancestral effective population size than previous works and did not infer a bottleneck history. Together, our results demonstrate the broad potential for two-locus statistics to enable powerful population genetic inference. Copyright © 2017 by the Genetics Society of America.

  8. Stock vs. Bond Yields, and Demographic Fluctuations

    DEFF Research Database (Denmark)

    Gozluklu, Arie; Morin, Annaïg

    that the slow-evolving time-series covariation due to changing population age structure accounts for the equilibrium relation between stock and bond markets. As a result, by exploiting the demographic information into distant future, the forecasting performance of evaluation models improves. Finally, using...... a cross-country panel, we document the cross-sectional variation of the demographic effect and explain the cross-country differences in comovement between stock and bond markets.......This paper analyzes the strong comovement between real stock and nominal bond yields at generational (low) frequencies. Life-cycle patterns in savings behavior in an overlapping generations model with cash-in-advance constraints explain this persistent comovement between financial yields. We argue...

  9. Stock vs. Bond Yields, and Demographic Fluctuations

    DEFF Research Database (Denmark)

    Gozluklu, Arie; Morin, Annaïg

    that the slow-evolving time-series covariation due to changing population age structure accounts for the equilibrium relation between stock and bond markets. As a result, by exploiting the demographic information into distant future, the forecasting performance of evaluation models improves. Finally, using...... a cross-country panel, we document the cross-sectional variation of the demographic effect and explain the cross-country differences in comovement between stock and bond markets.......This paper analyzes the strong comovement between real stock and nominal bond yields at generational (low) frequencies. Life-cycle patterns in savings behavior in an overlapping generations model with cash-in-advance constraints explain this persistent comovement between financial yields. We argue...

  10. New Approaches to Demographic Data Collection

    Science.gov (United States)

    Treiman, Donald J.; Lu, Yao; Qi, Yaqiang

    2013-01-01

    As population scientists have expanded the range of topics they study, increasingly considering the interrelationship between population phenomena and social, economic, and health conditions, they have expanded the kinds of data collected and have brought to bear new data collection techniques and procedures, often borrowed from other fields. These new approaches to demographic data collection are the concern of this essay. We consider three main topics: new developments in sampling procedures; new developments in fieldwork procedures; and new developments in the kind of information collected in demographic and social surveys. We conclude with some comments on data sharing in the social research community and a list of major Chinese surveys publicly available to researchers. Where possible we illustrate our points with Chinese examples. PMID:23844330

  11. A coupled phylogeographical and species distribution modelling approach recovers the demographical history of a Neotropical seasonally dry forest tree species.

    Science.gov (United States)

    Collevatti, Rosane G; Terribile, Levi Carina; Lima-Ribeiro, Matheus S; Nabout, João C; de Oliveira, Guilherme; Rangel, Thiago F; Rabelo, Suelen G; Diniz-Filho, Jose A F

    2012-12-01

    We investigated here the demographical history of Tabebuia impetiginosa (Bignoniaceae) to understand the dynamics of the disjunct geographical distribution of South American seasonally dry forests (SDFs), based on coupling an ensemble approach encompassing hindcasting species distribution modelling and statistical phylogeographical analysis. We sampled 17 populations (280 individuals) in central Brazil and analysed the polymorphisms at chloroplast (trnS-trnG, psbA-trnH, and ycf6-trnC intergenic spacers) and nuclear (ITS nrDNA) genomes. Phylogenetic analyses based on median-joining network showed no haplotype sharing among population but strong evidence of incomplete lineage sorting. Coalescent analyses showed historical constant populations size, negligible gene flow among populations, and an ancient time to most recent common ancestor dated from ~4.7 ± 1.1 Myr BP. Most divergences dated from the Lower Pleistocene, and no signal of important population size reduction was found in coalescent tree and tests of demographical expansion. Demographical scenarios were built based on past geographical range dynamic models, using two a priori biogeographical hypotheses ('Pleistocene Arc' and 'Amazonian SDF expansion') and on two additional hypotheses suggested by the palaeodistribution modelling built with several algorithms for distribution modelling and palaeoclimatic data. The simulation of these demographical scenarios showed that the pattern of diversity found so far for T. impetiginosa is in consonance with a palaeodistribution expansion during the last glacial maximum (LGM, 21 kyr BP), strongly suggesting that the current disjunct distribution of T. impetiginosa in SDFs may represent a climatic relict of a once more wide distribution.

  12. The demographic cycle and optimal schooling choices.

    Science.gov (United States)

    Jeon, B P; Berger, M C

    1996-10-01

    A model is developed that enables the authors to estimate the effects of demographic cycles on both earnings and schooling. The model is tested using data from the 1991 Korean Occupational Wage Survey. The results indicate that cohorts following large birth cohorts in the cycle choose relatively less formal schooling compared to pre-peak cohorts, and that post-peak cohorts also have lower incomes. This result concerning South Korea is consistent with findings from previous studies concerning the United States.

  13. Regions of Demographic Dynamism in Haryana

    OpenAIRE

    Sanjeev Goel

    2014-01-01

    There are different types of population structures in different parts of the world, the nature of demographic challenges also differ accordingly. The developed countries like USA, Canada, Japan, Australia and many European countries face a problem of slow or even negative population growth. The main concern of the government in these countries remains on population ageing, decline in working force and increasing dependency ratio. The developing countries like India, Pakistan, Bangladesh and L...

  14. TEENAGE PREGNANCY: DEMOGRAPHICS, MATERNAL AND FOETAL OUTCOME

    OpenAIRE

    Radhika Gollapudi; Jagadeeshwari Sistla

    2016-01-01

    BACKGROUND Pregnancy though is a physiological event in a woman’s life, it has its own associated complications. In teenage pregnancies, the physical and emotional state of stress coupled with biological immaturity leads to adverse effect both on the health of the mother and the foetus. METHODS This study is a clinical prospective study analysing the demographics, maternal health issues and the foetal outcome in teenage pregnancies. The study was conducted over a period of o...

  15. Mortality versus Morbidity in the Demographic Transition

    OpenAIRE

    Aksan, Anna-Maria; Chakraborty, Shankha

    2014-01-01

    The link between the mortality and epidemiological transitions is used to identify the effect of the former on the fertility transition: a mortality transition that is not accompanied by improving morbidity causes slower demographic and economic change. In a model where children may die from infectious disease, childhood health affects human capital and noninfectious-disease-related adult mortality. When child mortality falls from lower prevalence, as it did in western Europe, labor productiv...

  16. Evolving demographics of advanced dental education.

    Science.gov (United States)

    Waldman, H Barry; Perlman, Steven P; Cinotti, Debra A

    2009-01-01

    The numbers of dental school graduates and students enrolled in post graduate programs have increased. Decreases are noted in the enrollment in Periodontics and Prosthodontics programs and a marked increase in the enrollment in Pediatric Dentistry programs. A review of these changes, by gender and race/ethnicity provides an overview of the future demographics of the profession. Some concerns regarding the future are considered.

  17. [[Demographic characteristics of "business bachelors" in Japan

    Science.gov (United States)

    Yamamoto, C

    1987-01-01

    The demographic characteristics of those obliged to live away from their families because of the distance between their normal homes and places of work or education in Japan are described. Data are from a variety of official and other sources. The author notes that such persons are generally male. Factors affecting the growth of this phenomenon in Japan are the concept of lifetime employment with the same company and the popularity of sending children away to school.

  18. Frequency and socio-demographic correlates of eating meals out and take-away meals at home: cross-sectional analysis of the UK national diet and nutrition survey, waves 1-4 (2008-12).

    Science.gov (United States)

    Adams, Jean; Goffe, Louis; Brown, Tamara; Lake, Amelia A; Summerbell, Carolyn; White, Martin; Wrieden, Wendy; Adamson, Ashley J

    2015-04-16

    Food prepared out-of-home tends to be less healthful than food prepared at home, with a positive association between frequency of consumption and both fat intake and body fatness. There is little current data on who eats out-of-home food. We explored frequency and socio-demographic correlates of eating meals out and take-away meals at home, using data from a large, UK, population representative study. Data were from waves 1-4 of the UK National Diet and Nutrition Survey (2008-12). Socio-demographic variables of interest were gender, age group, and socio-economic position. Self-reported frequency of consuming meals out and take-away meals at home was categorised as: less than once per week and once per week or more. Analyses were performed separately for adults (aged 18 years or older) and children. Data from 2001 adults and 1963 children were included. More than one quarter (27.1%) of adults and one fifth (19.0%) of children ate meals out once per week or more. One fifth of adults (21.1%) and children (21.0%) ate take-away meals at home once per week or more. There were no gender differences in consumption of meals out, but more boys than girls ate take-away meals at home at least weekly. The proportion of participants eating both meals out and take-away meals at home at least weekly peaked in young adults aged 19-29 years. Adults living in more affluent households were more likely to eat meals out at least once per week, but children living in less affluent households were more likely to eat take-away meals at home at least once per week. There was no relationship between socio-economic position and consumption of take-away meals at home in adults. One-fifth to one-quarter of individuals eat meals prepared out-of-home weekly. Interventions seeking to improve dietary intake by reducing consumption of out-of-home food may be more effective if tailored to and targeted at adults aged less than 30 years. It may also be important to develop interventions to help

  19. Demographics of paediatric renal replacement therapy in Europe

    DEFF Research Database (Denmark)

    Chesnaye, Nicholas; Bonthuis, Marjolein; Schaefer, Franz;

    2014-01-01

    BACKGROUND: The ESPN/ERA-EDTA Registry collects data on European children with end-stage renal disease receiving renal replacement therapy (RRT) who are listed on national and regional renal registries in Europe. In this paper we report on the analysis of demographic data collected from 2009...... to 2011. METHODS: Data on primary renal disease, incidence, prevalence, 4-year survival, transplantation rate and causes of death in paediatric patients receiving RRT were extracted from the ESPN/ERA-EDTA Registry for 37 European countries. RESULTS: The incidence of RRT in paediatric patients in Europe...

  20. Entropy Based Modelling for Estimating Demographic Trends.

    Directory of Open Access Journals (Sweden)

    Guoqi Li

    Full Text Available In this paper, an entropy-based method is proposed to forecast the demographical changes of countries. We formulate the estimation of future demographical profiles as a constrained optimization problem, anchored on the empirically validated assumption that the entropy of age distribution is increasing in time. The procedure of the proposed method involves three stages, namely: 1 Prediction of the age distribution of a country's population based on an "age-structured population model"; 2 Estimation the age distribution of each individual household size with an entropy-based formulation based on an "individual household size model"; and 3 Estimation the number of each household size based on a "total household size model". The last stage is achieved by projecting the age distribution of the country's population (obtained in stage 1 onto the age distributions of individual household sizes (obtained in stage 2. The effectiveness of the proposed method is demonstrated by feeding real world data, and it is general and versatile enough to be extended to other time dependent demographic variables.

  1. Rural Household Demographics, Livelihoods and the Environment.

    Science.gov (United States)

    de Sherbinin, Alex; Vanwey, Leah; McSweeney, Kendra; Aggarwal, Rimjhim; Barbieri, Alisson; Henry, Sabina; Hunter, Lori M; Twine, Wayne

    2008-02-01

    This paper reviews and synthesizes findings from scholarly work on linkages among rural household demographics, livelihoods and the environment. Using the livelihood approach as an organizing framework, we examine evidence on the multiple pathways linking environmental variables and the following demographic variables: fertility, migration, morbidity and mortality, and lifecycles. Although the review draws on studies from the entire developing world, we find the majority of micro-level studies have been conducted in either marginal (mountainous or arid) or frontier environments, especially Amazonia. Though the linkages are mediated by many complex and often context-specific factors, there is strong evidence that dependence on natural resources intensifies when households lose human and social capital through adult morbidity and mortality, and qualified evidence for the influence of environmental factors on household decision-making regarding fertility and migration. Two decades of research on lifecycles and land-cover change at the farm level have yielded a number of insights about how households make use of different land-use and natural resource management strategies at different stages. A thread running throughout the review is the importance of managing risk through livelihood diversification, ensuring future income security, and culture-specific norms regarding appropriate and desirable activities and demographic responses. Recommendations for future research are provided.

  2. Development of reprogenetics and its demographic aspects

    Directory of Open Access Journals (Sweden)

    Devedžić Mirjana M.

    2004-01-01

    Full Text Available The development of reprogenetics during the last two decades of the XX century has brought a new age of reproduction. The paper surveys different types of reprogenetics in a wider sense, i.e. different assisted reproductive technologies (ART that include manipulation of female reproductive cell out of a woman's womb. Development of reprogenetics is documented by available quantitative indicators of the number and success of ART procedures in developed countries at the beginning of the XXI century. Since 1978, when the first baby was born from in vitro fertilization, the number of children born that way has reached 1% of all children, and in some countries even over 3%. Moreover, existing documentation is incomplete and does not include all forms of assisted reproduction - in reality, the importance of assisted reproduction is even higher and becomes demographically significant. Hence the paper indicates existing and potential effects of the ART development on the demographic development i.e. on specific demographic aspects of this phenomenon. It also points out the effects on the level of fertility, on the changes of direct fertility determinants, and on the levels of mortality and infant mortality, as well as a new understanding of birth control, the possibility of affecting biological structures, and the changes of the fundaments of marriage and family. Development perspectives of reprogenetics are also being raised in the context of bioethical discussions and indicate ethical dilemmas related to assisted reproduction. Solutions to the dilemmas define the scope of applying new reproductive technologies in the future.

  3. Whole blood and apheresis donors in Quebec, Canada: Demographic differences and motivations to donate.

    Science.gov (United States)

    Charbonneau, Johanne; Cloutier, Marie-Soleil; Carrier, Élianne

    2015-12-01

    This study sought to compare demographics and donation motivations among plasma/platelet donors (PPDs) and whole blood donors (WBDs), in a voluntary and non-remunerated context. Motives to donate blood and demographic characteristics were collected through questionnaires completed by 795 WBDs and 473 PPDs. Comparison of WBDs and PPDs under chi-square tests showed that 17 out of 23 motivators were statistically different according to various demographic variables. These results demonstrate the existence of specific donor profiles both for WBDs and PPDs. Agencies should develop new recruitment strategies tailored to these donors, especially if they wish to convince WBDs to convert to apheresis donation.

  4. Demographic Structure and Expenditure of Chinese Urban Households-A Cohort