WorldWideScience

Sample records for delta 1-thc metabolites

  1. Human urinary excretion profile after smoking and oral administration of ( sup 14 C)delta 1-tetrahydrocannabinol

    Energy Technology Data Exchange (ETDEWEB)

    Johansson, E.; Gillespie, H.K.; Halldin, M.M. (BMC, Uppsala (Sweden))

    1990-05-01

    The urinary excretion profiles of delta 1-tetrahydrocannabinol (delta 1-THC) metabolites have been evaluated in two chronic and two naive marijuana users after smoking and oral administration of ({sup 14}C)delta 1-THC. Urine was collected for five days after each administration route and analyzed for total delta 1-THC metabolites by radioactivity determination, for delta 1-THC-7-oic acid by high-performance liquid chromatography, and for cross-reacting cannabinoids by the EMIT d.a.u. cannabinoid assay. The average urinary excretion half-life of {sup 14}C-labeled delta 1-THC metabolites was calculated to be 18.2 +/- 4.9 h (+/- SD). The excretion profiles of delta 1-THC-7-oic acid and EMIT readings were similar to the excretion profile of {sup 14}C-labeled metabolites in the naive users. However, in the chronic users the excretion profiles of delta 1-THC-7-oic acid and EMIT readings did not resemble the radioactive excretion due to the heavy influence from previous Cannabis use. Between 8-14% of the radioactive dose was recovered in the urine in both user groups after oral administration. Lower urinary recovery was obtained both in the chronic and naive users after smoking--5 and 2%, respectively.

  2. Novel /sup 125/I radioimmunoassay for the analysis of. delta. /sup 9/-tetrahydrocannabinol and its metabolites in human body fluids

    Energy Technology Data Exchange (ETDEWEB)

    Law, B.; Mason, P.A.; Moffat, A.C.; King, L.J.

    A cannabinoid radioimmunoassay (RIA) that detects some of the major ..delta../sup 9/-THC metabolites is developed and evaluated for use in forensic science. It incorporates a novel /sup 125/I radiotracer, is sensitive, reliable, relatively quick, and simple to use. The RIA uses a commercially available antiserum and detects a number of cannabinoid metabolites, including ..delta../sup 9/-THC-11-oic acid and its glucuronide conjugate in biological fluids. The method was successfully applied to the analysis of blood and urine samples submitted for forensic analysis.

  3. Determination of plasma and urine levels of Delta9-tetrahydrocannabinol and its main metabolite by liquid chromatography after solid-phase extraction.

    Science.gov (United States)

    Mercolini, Laura; Musenga, Alessandro; Comin, Irene; Baccini, Cesare; Conti, Matteo; Raggi, Maria Augusta

    2008-05-12

    Delta9-Tetrahydrocannabinol is the most widespread drug of abuse in the world and it is also currently available as the active principle of formulations for the treatment of chronic pain. Its main metabolite, 11-nor-Delta9-tetrahydrocannabinol-9-carboxylic acid, is the most important marker of Delta9-tetrahydrocannabinol consumption. An original liquid chromatographic method has been developed for the determination of these two analytes in human plasma and urine. Separation was obtained on a C8 column using a mobile phase with 35% phosphate buffer at pH 2.7 and 65% acetonitrile. The UV detector was set at 220 nm and indomethacin was used as the internal standard. Sample pre-treatment was carried out by solid-phase extraction with C8 cartridges; urine samples were subjected to basic hydrolysis before extraction. Both extraction yields (>91%) and precision values were highly satisfactory. The method was successfully applied to biological samples collected from Cannabis users. Accuracy and selectivity results were satisfactory. This is the first HPLC-UV method developed for the simultaneous quantification of Delta9-tetrahydrocannabinol and 11-nor-Delta9-tetrahydrocannabinol-9-carboxylic acid in both plasma and urine for the monitoring of either therapeutic or recreational use.

  4. delta 1-Tetrahydrocannabinol-induced circling behavior in rats : a possible measure of psychotomimetic activity?

    NARCIS (Netherlands)

    Nir, I; Veldhuis, H D; van Ree, J M

    1984-01-01

    Relatively high dosages of delta 1-tetrahydrocannabinol (delta 1-THC) markedly suppressed almost all normally occurring behavioral elements in rats as observed in both a small and a large open field. This effect persisted following repeated treatment and testing for 3 consecutive days. The psychotro

  5. The analysis of delta9-tetrahydrocannabinol and metabolite in whole blood and 11-nor-delta9-tetrahydrocannabinol-9-carboxylic acid in urine using disposable pipette extraction with confirmation and quantification by gas chromatography-mass spectrometry.

    Science.gov (United States)

    Schroeder, Jennifer L; Marinetti, Laureen J; Smith, Roy K; Brewer, William E; Clelland, Brandi L; Morgan, Stephen L

    2008-10-01

    Essential to forensic laboratories is the desire to find a more sensitive, rapid method of analyzing Delta9-tetrahydrocannabinol (THC) and metabolite in biological specimens. Disposable pipette extraction (DPX) is a valuable method in extracting THC and 11-nor-Delta9-tetrahydrocannabinol-9-carboxylic acid (THCc) in blood and THCc in urine. Less waste and solvent usage; smaller specimen volume; clean chromatograms; and utilization of lowcost equipment and consumables were achieved using this method. Differing from traditional solid-phase extraction devices, DPX uses loosely packed sorbent allowing thorough mixing with the specimen without requiring vacuum for elution. Prior to extraction, urine specimens were hydrolyzed and proteins precipitated from blood. Specimen volume requirements were 1 mL of blood and 0.2 mL of urine. The limits of quantitation for THC and THCc in blood were 1 and 2 ng/mL, respectively, and 3 ng/mL for THCc in urine. With R2 values > or = 0.99, blood calibration curves were linear from 1 to 200 ng/mL and 2 to 500 ng/mL for THC and THCc, respectively, with urine THCc linear from 3 to 2000 ng/mL.

  6. Analytical Methodologies for Detection of Gamma-Valerolactone, Delta-Valerolactone, Acephate and Azinphos Methyl and Their Associated Metabolites in Complex Biological Matrices

    Energy Technology Data Exchange (ETDEWEB)

    Zink, E.; Clark, R.; Grant, K.; Campbell, J.; Hoppe, E.

    2005-01-01

    Non-invasive biomonitoring for chemicals of interest in law enforcement and similar monitoring of pesticides, together with their metabolites, can not only save money but can lead to faster medical attention for individuals exposed to these chemicals. This study describes methods developed for the analysis of gamma-valerolactone (GVL), delta-valerolactone (DVL), acephate, and azinphos methyl in saliva and serum. Liquid chromatography/mass spectrometry (LC/MS) operated in the negative and positive ion mode and gas chromatography/mass spectrometry (GC/MS) were used to analyze GVL and DVL. Although both analytical techniques worked well, lower detection limits were obtained with GC/MS. The lactones and their corresponding sodium salts were spiked into both saliva and serum. The lactones were isolated from saliva or serum using newly developed extraction techniques and then subsequently analyzed using GC/MS. The sodium salts of the lactones are nonvolatile and require derivatization prior to analysis by this method. N-methyl-N-(t-butyldimethylsilyl)-trifluoroacetamide (MTBSTFA) was ultimately selected as the reagent for derivatization because the acidic conditions required for reactions with diazomethane caused the salts to undergo intramolecular cyclization to the corresponding lactones. In vitro studies were conducted using rat liver microsomes to determine other metabolites associated with these compounds. Azinphos methyl and acephate are classified as organophosphate pesticides, and are known to be cholinesterase inhibitors in humans and insects, causing neurotoxicity. For this reason they have both exposure and environmental impact implications. These compounds were spiked into serum and saliva and prepared for analysis by GC/MS. Continuation of this research would include analysis by GC/MS under positive ion mode to determine the parent ions of the unknown metabolites. Further research is planned through an in vivo analysis of the lactones and pesticides. These

  7. Analytical Methodologies for Detection of Gamma-Valerolactone, Delta-Valerolactone, Acephate and Azinphos Methyl and Their Associated Metabolites in Complex Biological Matrices

    Energy Technology Data Exchange (ETDEWEB)

    Zink, E.; Clark, R.; Grant, K.; Campbell, J.; Hoppe, E.

    2005-01-01

    Non-invasive biomonitoring for chemicals of interest in law enforcement and similar monitoring of pesticides, together with their metabolites, can not only save money but can lead to faster medical attention for individuals exposed to these chemicals. This study describes methods developed for the analysis of gamma-valerolactone (GVL), delta-valerolactone (DVL), acephate, and azinphos methyl in saliva and serum. Liquid chromatography/mass spectrometry (LC/MS) operated in the negative and positive ion mode and gas chromatography/mass spectrometry (GC/MS) were used to analyze GVL and DVL. Although both analytical techniques worked well, lower detection limits were obtained with GC/MS. The lactones and their corresponding sodium salts were spiked into both saliva and serum. The lactones were isolated from saliva or serum using newly developed extraction techniques and then subsequently analyzed using GC/MS. The sodium salts of the lactones are nonvolatile and require derivatization prior to analysis by this method. N-methyl-N-(t-butyldimethylsilyl)-trifluoroacetamide (MTBSTFA) was ultimately selected as the reagent for derivatization because the acidic conditions required for reactions with diazomethane caused the salts to undergo intramolecular cyclization to the corresponding lactones. In vitro studies were conducted using rat liver microsomes to determine other metabolites associated with these compounds. Azinphos methyl and acephate are classified as organophosphate pesticides, and are known to be cholinesterase inhibitors in humans and insects, causing neurotoxicity. For this reason they have both exposure and environmental impact implications. These compounds were spiked into serum and saliva and prepared for analysis by GC/MS. Continuation of this research would include analysis by GC/MS under positive ion mode to determine the parent ions of the unknown metabolites. Further research is planned through an in vivo analysis of the lactones and pesticides. These

  8. Abstinence phenomena of chronic cannabis-addicts prospectively monitored during controlled inpatient detoxification (Part II): Psychiatric complaints and their relation to delta-9-tetrahydrocannabinol and its metabolites in serum.

    Science.gov (United States)

    Bonnet, Udo; Borda, Thorsten; Scherbaum, Norbert; Specka, Michael

    2015-10-01

    To investigate the impact of inpatient detoxification treatment on psychiatric symptoms of chronic cannabis addicts and to analyze the influence of serum cannabinoid levels on the severity of these symptoms. Thirty five treatment-seeking, not active co-morbid chronic cannabis dependents (ICD-10) were studied on admission and on abstinence days 8 and 16, using several observational and self-report scales, such as Hamilton Depression Rating Scale (HAMD), Hamilton Anxiety Rating Scale (HAMA), Young Mania Rating Scale (YMRS) and Brief Psychiatric Rating Scale (BPRS), and the Symptom Checklist-90-Revised (SCL-90-R). Simultaneously obtained serum was analyzed with regard to levels of delta-9-tetrahydrocannabinol (THC) and its main metabolites 11-hydroxy-delta-9-tetrahydrocannabinol (THC-OH) and 11-nor-delta-9-tetrahydrocannabinol-9-carboxylic acid (THC-COOH). At admission, nearly 90% of the patients were not, or only mildly, affected by depression, anxiety or manic symptoms. In contrast, patients' self-description indicated a strong psychiatric burden in approximately 60% of the cases. All patients improved significantly within 16 days of the treatment. Effect sizes ranged from 0.7 to 1.4. (Cohen's d) for the respective scales. Serum THC-levels were positively associated with impairment of cognition in HAMA and motor retardation in BPRS. All other test results were not significantly related to the serum levels of the measured cannabinoids. Effects of the cannabis withdrawal syndrome and executive dysfunctions might explain the discrepancy between the observer ratings and self-reported psychiatric burden. Inpatient cannabis detoxification treatment significantly improved psychiatric symptoms. Serum THC-levels were not associated with affective symptoms and anxiety but predicted cognitive impairment and motor retardation. Copyright © 2015. Published by Elsevier Ireland Ltd.

  9. Studies on the metabolism of the Delta9-tetrahydrocannabinol precursor Delta9-tetrahydrocannabinolic acid A (Delta9-THCA-A) in rat using LC-MS/MS, LC-QTOF MS and GC-MS techniques.

    Science.gov (United States)

    Jung, Julia; Meyer, Markus R; Maurer, Hans H; Neusüss, Christian; Weinmann, Wolfgang; Auwärter, Volker

    2009-10-01

    In Cannabis sativa, Delta9-Tetrahydrocannabinolic acid-A (Delta9-THCA-A) is the non-psychoactive precursor of Delta9-tetrahydrocannabinol (Delta9-THC). In fresh plant material, about 90% of the total Delta9-THC is available as Delta9-THCA-A. When heated (smoked or baked), Delta9-THCA-A is only partially converted to Delta9-THC and therefore, Delta9-THCA-A can be detected in serum and urine of cannabis consumers. The aim of the presented study was to identify the metabolites of Delta9-THCA-A and to examine particularly whether oral intake of Delta9-THCA-A leads to in vivo formation of Delta9-THC in a rat model. After oral application of pure Delta9-THCA-A to rats (15 mg/kg body mass), urine samples were collected and metabolites were isolated and identified by liquid chromatography-mass spectrometry (LC-MS), liquid chromatography-tandem mass spectrometry (LC-MS/MS) and high resolution LC-MS using time of flight-mass spectrometry (TOF-MS) for accurate mass measurement. For detection of Delta9-THC and its metabolites, urine extracts were analyzed by gas chromatography-mass spectrometry (GC-MS). The identified metabolites show that Delta9-THCA-A undergoes a hydroxylation in position 11 to 11-hydroxy-Delta9-tetrahydrocannabinolic acid-A (11-OH-Delta9-THCA-A), which is further oxidized via the intermediate aldehyde 11-oxo-Delta9-THCA-A to 11-nor-9-carboxy-Delta9-tetrahydrocannabinolic acid-A (Delta9-THCA-A-COOH). Glucuronides of the parent compound and both main metabolites were identified in the rat urine as well. Furthermore, Delta9-THCA-A undergoes hydroxylation in position 8 to 8-alpha- and 8-beta-hydroxy-Delta9-tetrahydrocannabinolic acid-A, respectively, (8alpha-Hydroxy-Delta9-THCA-A and 8beta-Hydroxy-Delta9-THCA-A, respectively) followed by dehydration. Both monohydroxylated metabolites were further oxidized to their bishydroxylated forms. Several glucuronidation conjugates of these metabolites were identified. In vivo conversion of Delta9-THCA-A to Delta9-THC was

  10. Observational $\\Delta\

    CERN Document Server

    Hernández, Antonio García; Monteiro, Mário J P F G; Suárez, Juan Carlos; Reese, Daniel R; Pascual-Granado, Javier; Garrido, Rafael

    2015-01-01

    Delta Scuti ($\\delta$ Sct) stars are intermediate-mass pulsators, whose intrinsic oscillations have been studied for decades. However, modelling their pulsations remains a real theoretical challenge, thereby even hampering the precise determination of global stellar parameters. In this work, we used space photometry observations of eclipsing binaries with a $\\delta$ Sct component to obtain reliable physical parameters and oscillation frequencies. Using that information, we derived an observational scaling relation between the stellar mean density and a frequency pattern in the oscillation spectrum. This pattern is analogous to the solar-like large separation but in the low order regime. We also show that this relation is independent of the rotation rate. These findings open the possibility of accurately characterizing this type of pulsator and validate the frequency pattern as a new observable for $\\delta$ Sct stars.

  11. Delta robot

    NARCIS (Netherlands)

    Herder, J.L.; Van der Wijk, V.

    2010-01-01

    The invention relates to a delta robot comprising a stationary base (2) and a movable platform (3) that is connected to the base with three chains of links (4,5,6), and comprising a balancing system incorporating at least one pantograph (7) for balancing the robot's center of mass, wherein the at le

  12. Delta robot

    NARCIS (Netherlands)

    Herder, J.L.; Van der Wijk, V.

    2010-01-01

    The invention relates to a delta robot comprising a stationary base (2) and a movable platform (3) that is connected to the base with three chains of links (4,5,6), and comprising a balancing system incorporating at least one pantograph (7) for balancing the robot's center of mass, wherein the at le

  13. Morphine metabolites

    DEFF Research Database (Denmark)

    Christrup, Lona Louring

    1997-01-01

    , morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G) are the major metabolites of morphine. The metabolism of morphine occurs not only in the liver, but may also take place in the brain and the kidneys. The glucuronides are mainly eliminated via bile and urine. Glucuronides as a rule...

  14. Delta III—an evolutionary delta growth

    Science.gov (United States)

    Arvesen, R. J.; Simpson, J. S.

    1996-03-01

    In order to remain competitive in the future and expand the McDonnell Douglas Aerospace market share, MDA has developed an expendable launch system strategy that devices cost-effective launch systems from the Delta II with a growth vehicle configuration called Delta III. The Delta III evolves from the Delta II launch system through development of a larger payload fairing (4-meter diameter), new cryogenically propelled upper stage, new first stage fuel tank, and larger strap-on solid rocket motors. We are developing the Delta III using Integrated Product Development Teams that capitalize on the experience base that has led us to a world record breaking mission success of 49 consecutive Delta II missions. The Delta III first-launch capability is currently planned for the spring of 1998 in support of our first spacecraft customer, Hughes Space and Communications International.

  15. Volatile Metabolites

    Directory of Open Access Journals (Sweden)

    Daryl D. Rowan

    2011-11-01

    Full Text Available Volatile organic compounds (volatiles comprise a chemically diverse class of low molecular weight organic compounds having an appreciable vapor pressure under ambient conditions. Volatiles produced by plants attract pollinators and seed dispersers, and provide defense against pests and pathogens. For insects, volatiles may act as pheromones directing social behavior or as cues for finding hosts or prey. For humans, volatiles are important as flavorants and as possible disease biomarkers. The marine environment is also a major source of halogenated and sulfur-containing volatiles which participate in the global cycling of these elements. While volatile analysis commonly measures a rather restricted set of analytes, the diverse and extreme physical properties of volatiles provide unique analytical challenges. Volatiles constitute only a small proportion of the total number of metabolites produced by living organisms, however, because of their roles as signaling molecules (semiochemicals both within and between organisms, accurately measuring and determining the roles of these compounds is crucial to an integrated understanding of living systems. This review summarizes recent developments in volatile research from a metabolomics perspective with a focus on the role of recent technical innovation in developing new areas of volatile research and expanding the range of ecological interactions which may be mediated by volatile organic metabolites.

  16. The Delta 2 launcher

    Science.gov (United States)

    Ousley, Gilbert W., Sr.

    1991-12-01

    The utilization of the Delta 2 as the vehicle for launching Aristoteles into its near Sun synchronous orbit is addressed. Delta is NASA's most reliable launch vehicle and is well suited for placing the present Aristoteles spacecraft into a 400 m circular orbit. A summary of some of the Delta 2 flight parameters is presented. Diagrams of a typical Delta 2 two stage separation are included along with statistics on delta reliability and launch plans.

  17. Delta Plaza kohvik = Delta Plaza cafe

    Index Scriptorium Estoniae

    2010-01-01

    Tallinnas Pärnu mnt 141 asuva kohviku Delta Plaza sisekujundusest. Sisearhitektid Tiiu Truus ja Marja Viltrop (Stuudio Truus OÜ). Tiiu Truusi tähtsamate tööde loetelu. Büroohoone Delta Plaza arhitektid Marika Lõoke ja Jüri Okas (AB J. Okas & M. Lõoke)

  18. Delta Plaza kohvik = Delta Plaza cafe

    Index Scriptorium Estoniae

    2010-01-01

    Tallinnas Pärnu mnt 141 asuva kohviku Delta Plaza sisekujundusest. Sisearhitektid Tiiu Truus ja Marja Viltrop (Stuudio Truus OÜ). Tiiu Truusi tähtsamate tööde loetelu. Büroohoone Delta Plaza arhitektid Marika Lõoke ja Jüri Okas (AB J. Okas & M. Lõoke)

  19. Delta hedging strategies comparison

    DEFF Research Database (Denmark)

    De Giovanni, Domenico; Ortobelli, S.; Rachev, S.T.

    2008-01-01

    In this paper we implement dynamic delta hedging strategies based on several option pricing models. We analyze different subordinated option pricing models and we examine delta hedging costs using ex-post daily prices of S&P 500. Furthermore, we compare the performance of each subordinated model ...

  20. Horizontal Symmetries $\\Delta(150)$ and $\\Delta(600)$

    CERN Document Server

    Lam, C S

    2013-01-01

    Using group theory of mixing to examine all finite subgroups of SU(3) with an order less than 512, we found recently that only the group $\\Delta(150)$ can give rise to a correct reactor angle $\\th_{13}$ of neutrino mixing without any free parameter. It predicts $\\sin^22\\th_{13}=0.11$ and a sub-maximal atmospheric angle with $\\sin^22\\th_{23}=0.94$, in good agreement with experiment. The solar angle $\\th_{12}$, the CP phase $\\d$, and the neutrino masses $m_i$ are left as free parameters. In this article we provide more details of this case, discuss possible gain and loss by introducing right-handed symmetries, and/or valons to construct dynamical models. A simple model is discussed where the solar angle agrees with experiment, and all its mixing parameters can be obtained from the group $\\Delta(600)$ by symmetry alone. The promotion of $\\Delta(150)$ to $\\Delta(600)$ is on the one hand analogous to the promotion of $S_3$ to $S_4$ in the presence of tribimaximal mixing, and on the other hand similar to the extens...

  1. On the width of N-Delta and Delta-Delta states

    CERN Document Server

    Niskanen, J A

    2016-01-01

    It is seen by a coupled-channel calculation that in the two-baryon N-Delta or Delta-Delta system the width of the state is greatly diminished due to the relative kinetic energy of the two baryons, since the internal energy of the particles, available for pionic decay, is smaller. A similar state dependent effect arises from the centrifugal barrier in N-Delta or Delta-Delta systems with non-zero orbital angular momentum. The double-Delta width can become even smaller than the free width of a single Delta. This has some bearing to the interpretation of the d'(2380) resonance recently discovered at COSY.

  2. geomorphology_delta

    Data.gov (United States)

    California Department of Resources — Surficial geology of the Delta area of California by Brian Atwater of the U.S. Geological Survey. Source maps are from the USGS publication MF-1401. This digital...

  3. Delta-Reliability

    OpenAIRE

    Eugster, P.; Guerraoui, R.; Kouznetsov, P.

    2001-01-01

    This paper presents a new, non-binary measure of the reliability of broadcast algorithms, called Delta-Reliability. This measure quantifies the reliability of practical broadcast algorithms that, on the one hand, were devised with some form of reliability in mind, but, on the other hand, are not considered reliable according to the ``traditional'' notion of broadcast reliability [HT94]. Our specification of Delta-Reliability suggests a further step towards bridging the gap between theory and...

  4. {\\delta}M Formalism

    CERN Document Server

    Talebian-Ashkezari, Alireza; Abolhasani, Ali Akbar

    2016-01-01

    We study the evolution of the "non-perturbative" metric perturbations in a Bianchi background in the long-wavelength limit. By applying the gradient expansion to the equations of motion we exhibit a generalized "Separate Universe" approach to the cosmological perturbation theory. Having found this consistent separate universe picture, we introduce the "{\\delta}M formalism" for calculating the evolution of the tensor perturbations in anisotropic inflation models in almost similar way as the so-called {\\delta}N formula for the super-horizon dynamics of the curvature perturbations. Likewise its ancestor, {\\delta}N formalism, this new method can substantially reduce the amount of calculations related to the evolution of the tensor modes.

  5. The Niger Delta Crisis

    African Journals Online (AJOL)

    chifaou.amzat

    2013-09-28

    Sep 28, 2013 ... lions de barils par jour à environ 1 million au plus fort de la crise du Delta ... (JTF) between 13 May 2009 and 4 October 2009 (the deadline for embrac- ..... He had just ended his welcome address as the occasion's chairman.

  6. Enhanced metabolite generation

    Science.gov (United States)

    Chidambaram, Devicharan [Middle Island, NY

    2012-03-27

    The present invention relates to the enhanced production of metabolites by a process whereby a carbon source is oxidized with a fermentative microbe in a compartment having a portal. An electron acceptor is added to the compartment to assist the microbe in the removal of excess electrons. The electron acceptor accepts electrons from the microbe after oxidation of the carbon source. Other transfers of electrons can take place to enhance the production of the metabolite, such as acids, biofuels or brewed beverages.

  7. Effect of conjugated linoleic acid on fungal delta6-desaturase activity in a transformed yeast system.

    Science.gov (United States)

    Chuang, L T; Thurmond, J M; Liu, J W; Kirchner, S J; Mukerji, P; Bray, T M; Huang, Y S

    2001-02-01

    Conjugated linoleic acid (CLA; 18:2), a group of positional and geometric isomers of linoleic acid (LA; 18:2n-6), has been shown to modulate immune function through its effect on eicosanoid synthesis. This effect has been attributed to a reduced production of n-6 polyunsaturated fatty acid (PUFA), the precursor of eicosanoids. Since delta6-desaturase is the rate-limiting enzyme of the n-6 PUFA production, it is our hypothesis that CLA, which has similar chemical structure to LA, interacts directly with delta6-desaturase. A unique and simple model, i.e., baker's yeast (Saccharomyces cerevisiae) transformed with fungal delta6-desaturase gene, previously established, was used to investigate the direct effect of CLA on delta6-desaturase. This model allows LA to be converted to y-linolenic acid (GLA; 18:3n-6) but not GLA to its metabolite(s). No metabolites of CLA were found in the lipids of the yeast transformed with delta6-desaturase. The inability to convert CLA to conjugated GLA was not due to the failure of yeast cells to take up the CLA isomers. CLA mixture and individual isomers significantly inhibited the activity of delta6-desaturase of the transformed yeast in vivo. Even though its uptake by the yeast was low, CLA c9,t11 isomer was found to be the most potent inhibitor of the four isomers tested, owing to its high inhibitory effect on delta6-desaturase. Since CLA did not cause significant changes in the level of delta6-desaturase mRNA, the inhibition of GLA production could not be attributed to suppression of delta6-desaturase gene expression at the transcriptional level.

  8. Identification of amygdalin and its major metabolites in rat urine by LC-MS/MS.

    Science.gov (United States)

    Ge, B Y; Chen, H X; Han, F M; Chen, Y

    2007-10-01

    Amygdalin and its metabolites in rat urine were identified using liquid chromatography-electrospray ionization (ESI) tandem ion-trap mass spectrometry. The purified rat urine sample was separated using a reversed-phase C18 column with 10 mM sodium phosphate buffer (pH 3.1) containing 30% methanol as the mobile phase, amygdalin and its metabolites were detected by on-line mass detector in selected ion monitoring (SIM) mode. The identification of the metabolites and elucidation of their structure were performed by comparing the changes in molecular masses (DeltaM), retention times and MS(2) spectral patterns of metabolites with those of parent drug. At least seven metabolites and the parent drug were found in rat urine after i.v. injection of 100 mg/kg doses of amygdalin. Among them, six metabolites were reported for the first time.

  9. DELTAS: A new Global Delta Sustainability Initiative (Invited)

    Science.gov (United States)

    Foufoula-Georgiou, E.

    2013-12-01

    Deltas are economic and environmental hotspots, food baskets for many nations, home to a large part of the world population, and hosts of exceptional biodiversity and rich ecosystems. Deltas, being at the land-water interface, are international, regional, and local transport hubs, thus providing the basis for intense economic activities. Yet, deltas are deteriorating at an alarming rate as 'victims' of human actions (e.g. water and sediment reduction due to upstream basin development), climatic impacts (e.g. sea level rise and flooding from rivers and intense tropical storms), and local exploration (e.g. sand or aggregates, groundwater and hydrocarbon extraction). Although many efforts exist on individual deltas around the world, a comprehensive global delta sustainability initiative that promotes awareness, science integration, data and knowledge sharing, and development of decision support tools for an effective dialogue between scientists, managers and policy makers is lacking. Recently, the international scientific community proposed to establish the International Year of Deltas (IYD) to serve as the beginning of such a Global Delta Sustainability Initiative. The IYD was proposed as a year to: (1) increase awareness and attention to the value and vulnerability of deltas worldwide; (2) promote and enhance international and regional cooperation at the scientific, policy, and stakeholder level; and (3) serve as a launching pad for a 10-year committed effort to understand deltas as complex socio-ecological systems and ensure preparedness in protecting and restoring them in a rapidly changing environment. In this talk, the vision for such an international coordinated effort on delta sustainability will be presented as developed by a large number of international experts and recently funded through the Belmont Forum International Opportunities Fund. Participating countries include: U.S., France, Germany, U.K., India, Japan, Netherlands, Norway, Brazil, Bangladesh

  10. Timelike gamma* N -> Delta form factors and Delta Dalitz decay

    CERN Document Server

    Ramalho, G

    2012-01-01

    We extend a covariant model, tested before in the spacelike region for the physical and lattice QCD regimes, to a calculation of the gamma* N -> Delta reaction in the timelike region, where the square of the transfered momentum, q^2, is positive (q^2>0). We estimate the Dalitz decay Delta -> Ne+e- and the Delta distribution mass distribution function. The results presented here can be used to simulate the NN -> NNe+e- reactions at moderate beam kinetic energies.

  11. Secondary metabolites from Ganoderma.

    Science.gov (United States)

    Baby, Sabulal; Johnson, Anil John; Govindan, Balaji

    2015-06-01

    Ganoderma is a genus of medicinal mushrooms. This review deals with secondary metabolites isolated from Ganoderma and their biological significance. Phytochemical studies over the last 40years led to the isolation of 431 secondary metabolites from various Ganoderma species. The major secondary compounds isolated are (a) C30 lanostanes (ganoderic acids), (b) C30 lanostanes (aldehydes, alcohols, esters, glycosides, lactones, ketones), (c) C27 lanostanes (lucidenic acids), (d) C27 lanostanes (alcohols, lactones, esters), (e) C24, C25 lanostanes (f) C30 pentacyclic triterpenes, (g) meroterpenoids, (h) farnesyl hydroquinones (meroterpenoids), (i) C15 sesquiterpenoids, (j) steroids, (k) alkaloids, (l) prenyl hydroquinone (m) benzofurans, (n) benzopyran-4-one derivatives and (o) benzenoid derivatives. Ganoderma lucidum is the species extensively studied for its secondary metabolites and biological activities. Ganoderma applanatum, Ganoderma colossum, Ganoderma sinense, Ganoderma cochlear, Ganoderma tsugae, Ganoderma amboinense, Ganoderma orbiforme, Ganoderma resinaceum, Ganoderma hainanense, Ganoderma concinna, Ganoderma pfeifferi, Ganoderma neo-japonicum, Ganoderma tropicum, Ganoderma australe, Ganoderma carnosum, Ganoderma fornicatum, Ganoderma lipsiense (synonym G. applanatum), Ganoderma mastoporum, Ganoderma theaecolum, Ganoderma boninense, Ganoderma capense and Ganoderma annulare are the other Ganoderma species subjected to phytochemical studies. Further phytochemical studies on Ganoderma could lead to the discovery of hitherto unknown biologically active secondary metabolites.

  12. Delta II commercial space transportation

    Science.gov (United States)

    Meyers, J. F.

    1988-07-01

    Delta II is an upgraded variant of the Delta family of launch vehicles that has been in use by NASA since 1960. Among the design improvements incorporated by Delta II is a cryogenic-propellant second stage, a 2.89-m diameter satellite-protecting nose fairing, graphite/epoxy solid rocket motor cases, and 12:1 main engine expansion nozzle. The manufacturer/operator offers Delta II customers a dedicated, single satellite launch capability fully tailored to the given spacecraft's unique mission requirements.

  13. Understanding and classifying metabolite space and metabolite-likeness.

    Directory of Open Access Journals (Sweden)

    Julio E Peironcely

    Full Text Available While the entirety of 'Chemical Space' is huge (and assumed to contain between 10(63 and 10(200 'small molecules', distinct subsets of this space can nonetheless be defined according to certain structural parameters. An example of such a subspace is the chemical space spanned by endogenous metabolites, defined as 'naturally occurring' products of an organisms' metabolism. In order to understand this part of chemical space in more detail, we analyzed the chemical space populated by human metabolites in two ways. Firstly, in order to understand metabolite space better, we performed Principal Component Analysis (PCA, hierarchical clustering and scaffold analysis of metabolites and non-metabolites in order to analyze which chemical features are characteristic for both classes of compounds. Here we found that heteroatom (both oxygen and nitrogen content, as well as the presence of particular ring systems was able to distinguish both groups of compounds. Secondly, we established which molecular descriptors and classifiers are capable of distinguishing metabolites from non-metabolites, by assigning a 'metabolite-likeness' score. It was found that the combination of MDL Public Keys and Random Forest exhibited best overall classification performance with an AUC value of 99.13%, a specificity of 99.84% and a selectivity of 88.79%. This performance is slightly better than previous classifiers; and interestingly we found that drugs occupy two distinct areas of metabolite-likeness, the one being more 'synthetic' and the other being more 'metabolite-like'. Also, on a truly prospective dataset of 457 compounds, 95.84% correct classification was achieved. Overall, we are confident that we contributed to the tasks of classifying metabolites, as well as to understanding metabolite chemical space better. This knowledge can now be used in the development of new drugs that need to resemble metabolites, and in our work particularly for assessing the metabolite

  14. Phenotypic expressions of CCR5-Delta 32/Delta 32 homozygosity

    NARCIS (Netherlands)

    Nguyen, GT; Carrington, M; Beeler, JA; Dean, M; Aledort, LM; Blatt, PM; Cohen, AR; DiMichele, D; Eyster, ME; Kessler, CM; Konkle, B; Leissinger, C; Luban, N; O'Brien, SJ; Goedert, JJ; O'Brien, TR

    1999-01-01

    Objective: As blockade of CC-chemokine receptor 5 (CCR5) has been proposed as therapy for HIV-1, we examined whether the CCR5-Delta 32/Delta 32 homozygous genotype has phenotypic expressions other than those related to HIV-1. Design: Study subjects were white homosexual men or men with hemophilia

  15. Phenotypic expressions of CCR5-Delta 32/Delta 32 homozygosity

    NARCIS (Netherlands)

    Nguyen, GT; Carrington, M; Beeler, JA; Dean, M; Aledort, LM; Blatt, PM; Cohen, AR; DiMichele, D; Eyster, ME; Kessler, CM; Konkle, B; Leissinger, C; Luban, N; O'Brien, SJ; Goedert, JJ; O'Brien, TR

    1999-01-01

    Objective: As blockade of CC-chemokine receptor 5 (CCR5) has been proposed as therapy for HIV-1, we examined whether the CCR5-Delta 32/Delta 32 homozygous genotype has phenotypic expressions other than those related to HIV-1. Design: Study subjects were white homosexual men or men with hemophilia wh

  16. Peat compaction in deltas : implications for Holocene delta evolution

    NARCIS (Netherlands)

    van Asselen, S.|info:eu-repo/dai/nl/304838101

    2010-01-01

    Many deltas contain substantial amounts of peat, which is the most compressible soil type. Therefore, peat compaction potentially leads to high amounts of subsidence in deltas. The main objective of this research was to quantify subsidence due to peat compaction in Holocene fluvial-deltaic settings

  17. Phenotypic expressions of CCR5-Delta 32/Delta 32 homozygosity

    NARCIS (Netherlands)

    Nguyen, GT; Carrington, M; Beeler, JA; Dean, M; Aledort, LM; Blatt, PM; Cohen, AR; DiMichele, D; Eyster, ME; Kessler, CM; Konkle, B; Leissinger, C; Luban, N; O'Brien, SJ; Goedert, JJ; O'Brien, TR

    1999-01-01

    Objective: As blockade of CC-chemokine receptor 5 (CCR5) has been proposed as therapy for HIV-1, we examined whether the CCR5-Delta 32/Delta 32 homozygous genotype has phenotypic expressions other than those related to HIV-1. Design: Study subjects were white homosexual men or men with hemophilia wh

  18. Tibolone and its metabolites acutely relax rabbit coronary arteries in vitro

    DEFF Research Database (Denmark)

    Lund, Claus Otto; Nilas, Lisbeth; Pedersen, Susan Helene

    2004-01-01

    under curve (AUC). RESULTS: Tibolone and its metabolites induced a concentration-dependent vasodilatation comparable to that of 17 beta-estradiol with the rank of potency: 3 beta-OH-tibolone approximately = to tibolone>3 alpha-OH-tibolone>Delta 4-isomer (ANOVA). l-NAME partly inhibited the relaxation...

  19. $\\Delta$-N Electromagnetic Transition

    CERN Document Server

    Loan, M

    1999-01-01

    The EM ratio for a free Delta electromagnetic transition is discussed within the frame work of nonrelativistic approach. Such an approach gives a good account of data for a free Delta but is less important for an intrinsically relativistic nuclear many body problem.

  20. Mida pakub Delta? / Teele Kurm

    Index Scriptorium Estoniae

    Kurm, Teele

    2011-01-01

    Politsei- ja Piirivalveamet võtab kasutusele ühise Siseministeeriumi infotehnoloogia- ja arenduskeskuse ning Webmedia AS koostööna loodud dokumendihaldussüsteemi Delta. Kust sai Delta oma nime? Projekti "Dokumendihaldussüsteemi juurutamine Siseministeeriumi haldusalas" eesmärgid

  1. Delta Electroproduction in 12-C

    Energy Technology Data Exchange (ETDEWEB)

    Steven McLauchlan

    2003-01-31

    The Delta-nucleus potential is a crucial element in the understanding of the nuclear system. Previous electroexcitation measurements in the delta region reported a Q2 dependence of the delta mass indicating that this potential is dependent on the momentum of the delta. Such a dependence is not observed for protons and neutrons in the nuclear medium. This thesis presents the experimental study of the electroexcitation of the delta resonance in 12C, performed using the high energy electron beam at the Thomas Jefferson National Accelerator Facility, and the near 4(pie) acceptance detector CLAS that enables the detection of the full reaction final state. Inclusive, semi inclusive, and exclusive cross sections were measured with an incident electron beam energy of 1.162GeV over the Q2 range 0.175-0.475 (GeV/c)2. A Q2 dependence of the delta mass was only observed in the exclusive measurements indicating that the delta-nucleus potential is affected by the momentum of the delta.

  2. Mida pakub Delta? / Teele Kurm

    Index Scriptorium Estoniae

    Kurm, Teele

    2011-01-01

    Politsei- ja Piirivalveamet võtab kasutusele ühise Siseministeeriumi infotehnoloogia- ja arenduskeskuse ning Webmedia AS koostööna loodud dokumendihaldussüsteemi Delta. Kust sai Delta oma nime? Projekti "Dokumendihaldussüsteemi juurutamine Siseministeeriumi haldusalas" eesmärgid

  3. Mackenzie River Delta, Canada

    Science.gov (United States)

    2007-01-01

    The Mackenzie River in the Northwest Territories, Canada, with its headstreams the Peace and Finley, is the longest river in North America at 4241 km, and drains an area of 1,805,000 square km. The large marshy delta provides habitat for migrating Snow Geese, Tundra Swans, Brant, and other waterfowl. The estuary is a calving area for Beluga whales. The Mackenzie (previously the Disappointment River) was named after Alexander Mackenzie who travelled the river while trying to reach the Pacific in 1789. The image was acquired on August 4, 2005, covers an area of 55.8 x 55.8 km, and is located at 68.6 degrees north latitude, 134.7 degrees west longitude. The U.S. science team is located at NASA's Jet Propulsion Laboratory, Pasadena, Calif. The Terra mission is part of NASA's Science Mission Directorate.

  4. DELTA 3D PRINTER

    Directory of Open Access Journals (Sweden)

    ȘOVĂILĂ Florin

    2016-07-01

    Full Text Available 3D printing is a very used process in industry, the generic name being “rapid prototyping”. The essential advantage of a 3D printer is that it allows the designers to produce a prototype in a very short time, which is tested and quickly remodeled, considerably reducing the required time to get from the prototype phase to the final product. At the same time, through this technique we can achieve components with very precise forms, complex pieces that, through classical methods, could have been accomplished only in a large amount of time. In this paper, there are presented the stages of a 3D model execution, also the physical achievement after of a Delta 3D printer after the model.

  5. WORLD DELTAS AND THEIR EVOLUTION

    Institute of Scientific and Technical Information of China (English)

    1999-01-01

    In August 1998, an international symposium on the world deltas was held in New Orleans, Louisiana, USA. This symposium attracted discussion about more than 25 deltas from around the world with emphasis placed on those that are most densely populated and impacted by humans. Keynote papers printed details about the physical, biological, engineering and socioeconomic aspects of six deltas including the Mississippi, Nile, Ganges-Brahmaputra, Rhine-Meuse, Changjiang and Po. The main purpose of this symposium was to inform scientists, engineers and decision-makers about information that is currently available and to provide them a basis for working in such environments.

  6. Dynamical Casimir effect with $\\delta-\\delta^{\\prime}$ mirrors

    CERN Document Server

    Silva, Jeferson Danilo L; Alves, Danilo T

    2016-01-01

    We calculate the spectrum and the total rate of created particles for a real massless scalar field in $1+1$ dimensions, in the presence of a partially transparent moving mirror simulated by a Dirac $\\delta-\\delta^{\\prime}$ point interaction. We show that, strikingly, a partially reflecting mirror can produce a larger number of particles in comparison with a perfectly reflecting one. In the limit of a perfect mirror, our formulas recover those found in the literature for the Robin boundary condition.

  7. Production of Metabolites

    DEFF Research Database (Denmark)

    2011-01-01

    A recombinant micro-organism such as Saccharomyces cerevisiae which produces and excretes into culture medium a stilbenoid metabolite product when grown under stilbenoid production conditions, which expresses in above native levels a ABC transporter which transports said stilbenoid out of said...... micro-organism cells to the culture medium. The genome of the Saccharomyces cerevisiae produces an auxotrophic phenotype which is compensated by a plasmid which also expresses one or more of said enzymes constituting said metabolic pathway producing said stilbenoid, an expression product of the plasmid...

  8. PARAMETRIC DESIGN OF DELTA ROBOT

    Directory of Open Access Journals (Sweden)

    Mert Gürgen

    2016-09-01

    Full Text Available This article describes a sophisticated determination and presentation of a workspace volume for a delta robot, with consideration of its kinematic behavior. With the help of theoretical equations, optimization is performed with the aid of the stiffness and dexterity analysis. Theoretical substructure is coded in Matlab and three-dimensional (3D data for delta robot are developed in computer-aided design (CAD environment. In later stages of the project, both 3D and theoretical data are linked together and thus, with the changing design parameter of the robot itself, the Solidworks CAD output adapts and regenerates output with a new set of parameters. To achieve an optimum workspace volume with predefined parameters, a different set of robot parameters are iterated through design optimization in Matlab, and the delta robot design is finalized and illustrated in the 3D CAD environment, Solidworks. This study provides a technical solution to accomplish a generic delta robot with optimized workspace volume.

  9. Student Difficulties with the Dirac Delta Function

    CERN Document Server

    Wilcox, Bethany R

    2014-01-01

    The Dirac delta function is a standard mathematical tool used in multiple topical areas in the undergraduate physics curriculum. While Dirac delta functions are usually introduced in order to simplify a problem mathematically, students often struggle to manipulate and interpret them. To better understand student difficulties with the delta function at the upper-division level, we examined responses to traditional exam questions and conducted think-aloud interviews. Our analysis was guided by an analytical framework that focuses on how students activate, construct, execute, and reflect on the Dirac delta function in physics. Here, we focus on student difficulties using the delta function to express charge distributions in the context of junior-level electrostatics. Challenges included: invoking the delta function spontaneously, constructing two- and three-dimensional delta functions, integrating novel delta function expressions, and recognizing that the delta function can have units.

  10. Rethinking cycad metabolite research.

    Science.gov (United States)

    Snyder, Laura R; Marler, Thomas E

    2011-01-01

    Cycads are among the most ancient of extant Spermatophytes, and are known for their numerous pharmacologically active compounds. One compound in particular, β-methylamino-L-alanine (BMAA), has been implicated as the cause of amyotrophic lateral sclerosis/Parkinson dementia complex (ALS/PDC) on Guam. Previous studies allege that BMAA is produced exclusively by cyanobacteria, and is transferred to cycads through the symbiotic relationship between these cyanobacteria and the roots of cycads. We recently published data showing that Cycas micronesica seedlings grown without endophytic cyanobacteria do in fact increase in BMAA, invalidating the foundation of the BMAA hypothesis. We use this example to suggest that the frenzy centered on BMAA and other single putative toxins has hindered progress. The long list of cycad-specific compounds may have important roles in signaling or communication, but these possibilities have been neglected during decades of attempts to force single metabolites into a supposed anti-herbivory function. We propose that an unbiased, comprehensive approach may be a more appropriate means of proceeding with cycad biochemistry research.

  11. Synthesis Of Labeled Metabolites

    Science.gov (United States)

    Martinez, Rodolfo A.; Silks, III, Louis A.; Unkefer, Clifford J.; Atcher, Robert

    2004-03-23

    The present invention is directed to labeled compounds, for example, isotopically enriched mustard gas metabolites including: [1,1',2,2'-.sup.13 C.sub.4 ]ethane, 1,1'-sulfonylbis[2-(methylthio); [1,1',2,2'-.sup.13 C.sub.4 ]ethane, 1-[[2-(methylsulfinyl)ethyl]sulfonyl]-2-(methylthio); [1,1',2,2'-.sup.13 C.sub.4 ]ethane, 1,1'-sulfonylbis[2-(methylsulfinyl)]; and, 2,2'-sulfinylbis([1,2-.sup.13 C.sub.2 ]ethanol of the general formula ##STR1## where Q.sup.1 is selected from the group consisting of sulfide (--S--), sulfone (--S(O)--), sulfoxide (--S(O.sub.2)--) and oxide (--O--), at least one C* is .sup.13 C, X is selected from the group consisting of hydrogen and deuterium, and Z is selected from the group consisting of hydroxide (--OH), and --Q.sup.2 --R where Q.sup.2 is selected from the group consisting of sulfide (--S--), sulfone(--S(O)--), sulfoxide (--S(O.sub.2)--) and oxide (--O--), and R is selected from the group consisting of hydrogen, a C.sub.1 to C.sub.4 lower alkyl, and amino acid moieties, with the proviso that when Z is a hydroxide and Q.sup.1 is a sulfide, then at least one X is deuterium.

  12. {Delta}I = 3/2 and {Delta}S = 2 Hyperon decays in chiral perturbation theory

    Energy Technology Data Exchange (ETDEWEB)

    He, X.G. [University of Melbourne, Parkville, VIC (Australia). School of Physics; Valencia, G. [Iowa State University, Ames, Iowa (United States). Department of Physics and Astronomy

    1997-05-01

    We study the| {Delta}I| = 3/2 and |{Delta}S| = 2 amplitudes for hyperon decays of the form B {yields} B`{pi} at lowest order in chiral perturbation theory. At this order, the {Delta}I = 3/2 amplitudes depend on only one constant. We extract the value of this constant from experiment and find a reasonable description of these processes within experimental errors. The same constant determines the {Delta}S = 2 transitions which, in the standard model, are too small to be observed. We find that new physics with parity odd {Delta}S = 2 interactions can produce observable rates in hyperon decays while evading the bounds from K{sup 0} - K-bar{sup 0} mixing. (authors) 10 refs., 3 tabs.

  13. Reactive versus anticipative adaptive management of Deltas: The Sacramento-San Joaquin Delta and the Rhine-Meuse Delta compared

    NARCIS (Netherlands)

    Vlieg, T.J.; Zandvoort, M.

    2013-01-01

    In this paper Californian Adaptive Management (AM) and Dutch Adaptive Delta Management (ADM) are compared. The concepts are introduced in a policy context to deal with prevailing types of uncertainty in water management in the Californian Sacramento-San Joaquin Delta and the Dutch Rhine-Meuse Delta

  14. Facts About Delta Pi Epsilon

    Science.gov (United States)

    Delta Pi Epsilon Journal, 1976

    1976-01-01

    The article discusses the purpose and structure of Delta Pi Epsilon and the general qualifications for membership. Service projects and publications, research awards, timely facts, the year of each chapter's origination, national presidents, and executive secretaries for the last 40 years are listed. (BP)

  15. Hydrological and Climatic Significance of Martian Deltas

    Science.gov (United States)

    Di Achille, G.; Vaz, D. A.

    2017-10-01

    We a) review the geomorphology, sedimentology, and mineralogy of the martian deltas record and b) present the results of a quantitative study of the hydrology and sedimentology of martian deltas using modified version of terrestrial model Sedflux.

  16. Yellow River Delta Faces a Historic Opportunity

    Institute of Scientific and Technical Information of China (English)

    Li Zhen

    2010-01-01

    @@ China's State Council has endorsed the Development Plan of an Efficient Eco-Economic Zone at Yellow River Delta. The plan is meant to create a more ecologically sustainable economic zone along the river delta.

  17. Yellow River Delta Faces a Historic Opportunity

    Institute of Scientific and Technical Information of China (English)

    Li Zhen

    2011-01-01

    @@ China's State Council has endorsed the Development Plan of an Efficient Eco-Economic Zone at Yellow River Delta.The plan is meant to create a more ecologically sustainable economic zone along the river delta.

  18. On the modelling of river delta formation

    NARCIS (Netherlands)

    Geleynse, N.

    2013-01-01

    This thesis presents approaches to the modelling of river delta formation. In particular, it provides results of numerical stratigraphic-morphodynamic modelling of river delta formation under various environmental forcings.

  19. Adaptive delta management: Roots and branches

    NARCIS (Netherlands)

    Timmermans, J.S.; Haasnoot, M.; Hermans, L.M.; Kwakkel, J.H.; Rutten, M.M.; Thissen, W.A.H.

    2015-01-01

    Deltas are generally recognized as vulnerable to climate change and therefore a salient topic in adaptation science. Deltas are also highly dynamic systems viewed from physical (erosion, sedimentation, subsidence), social (demographic), economic (trade), infrastructures (transport, energy, metropoli

  20. Delta Vegetation and Land Use [ds292

    Data.gov (United States)

    California Department of Resources — Vegetation and land use are mapped for the approximately 725,000 acres constituting the Legal Delta portion of the Sacramento and San Joaquin River Delta area....

  1. Metabolite Space of Rheumatoid Arthritis

    OpenAIRE

    van Wietmarschen, Herman; van der Greef, Jan

    2012-01-01

    Metabolites play numerous roles in the healthy and diseased body, ranging from regulating physiological processes to providing building blocks for the body. Therefore, understanding the role of metabolites is important in elucidating the etiology and pathology of diseases and finding targets for new treatment options. Rheumatoid arthritis is a complex chronic disease for which new disease management strategies are needed. The aim of this review is to bring together and integrate information a...

  2. Secondary metabolites from marine microorganisms

    Directory of Open Access Journals (Sweden)

    KELECOM ALPHONSE

    2002-01-01

    Full Text Available After 40 years of intensive research, chemistry of marine natural products has become a mature field. Since 1995, there are signals of decreased interest in the search of new metabolites from traditional sources such as macroalgae and octocorals, and the number of annual reports on marine sponges stabilized. On the contrary, metabolites from microorganisms is a rapidly growing field, due, at least in part, to the suspicion that a number of metabolites obtained from algae and invertebrates may be produced by associated microorganisms. Studies are concerned with bacteria and fungi, isolated from seawater, sediments, algae, fish and mainly from marine invertebrates such as sponges, mollusks, tunicates, coelenterates and crustaceans. Although it is still to early to define tendencies, it may be stated that the metabolites from microorganisms are in most cases quite different from those produced by the invertebrate hosts. Nitrogenated metabolites predominate over acetate derivatives, and terpenes are uncommon. Among the latter, sesquiterpenes, diterpenes and carotenes have been isolated; among nitrogenated metabolites, amides, cyclic peptides and indole alkaloids predominate.

  3. Limited junctional diversity of V delta 5-J delta 1 rearrangement in multiple sclerosis patients.

    Science.gov (United States)

    Nowak, J S; Michałowska-Wender, G; Januszkiewicz, D; Wender, M

    1997-01-01

    T-cell receptor (TCR) delta gene repertoire, as assessed by V delta-J delta rearrangements, has been analyzed in nine multiple sclerosis (MS) cases and in 30 healthy individuals by seminested PCR technique. Among the V delta-J delta junctional diversities studied, the most striking result has been observed in V delta 5-J delta 1 rearrangement. The detection of repeated V delta 5-J delta 1 nucleotide sequences in all analyzed clones from seven out of nine patients studied proved the monoclonal nature of gamma delta T-cells with V delta 5-J delta 1 rearrangement. The clonal nature of this rearrangement proved by PAGE and sequencing analysis may suggest an antigen-driven expansion of gamma delta T cells and argues for a significant role of gamma delta T-cells with V delta 5-J delta 1 rearrangement in MS pathogenesis. However, it cannot be excluded that clonal expansion of these lymphocytes may represent secondary change to central nervous system damage.

  4. Reflections on Development Strategy of Pearl River Delta: In Comparison with Yangtze River Delta

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    <正>1. A comparison between Pearl River Delta and Yangtze River Delta 1.1 Basic conditions 1.1.1 Location, area and scope Located in the southeast of Guangdong Province, the Pearl River Delta (PRD) as an economic zone is a compound delta

  5. What is $\\Delta m^2_{ee}$ ?

    CERN Document Server

    Parke, Stephen

    2016-01-01

    The current short baseline reactor experiments, Daya Bay and RENO (Double Chooz) have measured (or are capable of measuring) an effective $\\Delta m^2$ associated with the atmospheric oscillation scale of 0.5 km/MeV in electron anti-neutrino disappearance. In this paper, I compare and contrast the different definitions of such an effective $\\Delta m^2$ and argue that the simple, L/E independent, definition given by $\\Delta m^2_{ee} \\equiv \\cos^2 \\theta_{12} \\Delta m^2_{31}+ \\sin^2 \\theta_{12} \\Delta m^2_{32}$, i.e. "the $\

  6. [delta-Aminolevulinate dehydratase deficiency].

    Science.gov (United States)

    Fujita, H; Ishida, N; Akagi, R

    1995-06-01

    delta-Aminolevulinate dehydratase (ALAD: E. C. 4.2.1.24), the second enzyme in the heme biosynthetic pathway, condenses two moles of delta-aminolevulinic acid to form porphobilinogen. ALAD deficiency is well known to develop signs and symptoms of typical hepatic porphyria, and classified into three categories as follows: (i) ALAD porphyria, a genetic defect of the enzyme, (ii) tyrosinemia type I, a genetic defect of fumarylacetoacetase in the tyrosine catabolic pathway, producing succinylacetone (a potent inhibitor of ALAD), and (iii) ALAD inhibition by environmental hazards, such as lead, trichloroethylene, and styrene. In the present article, we will describe molecular and biochemical mechanisms to cause the enzyme defect to discuss the significance of ALAD defect on human health.

  7. Periodicity in Delta-modulated feedback control

    Institute of Scientific and Technical Information of China (English)

    Xiaohua XIA; Guanrong CHEN; Rudong GAI; Alan S. I. ZINOBER

    2008-01-01

    The Delta-modulated feedback control of a linear system introduces nonlinearity into the system through switchings between two input values. It has been found that Delta-modulation gives rise to periodic orbits. The existence of periodic points of all orders of Sigma-Delta modulation with "leaky" integration is completely characterized by some interesting groups of polynomials with "sign" coefficients. The results are naturally generalized to Sigma-Delta modulations with multiple delays, Delta-modulations in the "downlink", unbalanced Delta-modulations and systems with two-level quantized feedback. Further extensions relate to the existence of periodic points arising from Delta-modulated feedback control of a stable linear system in an arbitrary direction, for which some necessary and sufficient conditions are given.

  8. Entendiendo Delta desde las Humanidades

    OpenAIRE

    José Calvo Tello

    2016-01-01

    Stylometry is one of the research areas in greater development within Digital Humanities. However, few studies have worked until recently with texts in Spanish and even less so from Spanish-speaking countries. The aim of this paper is to present in Spanish, and without prior statistical knowledge from the reader, one of the main methods used in stylometry, the measure of textual distance Burrows’ Delta. This paper explains this measure using a very small corpus of proverbs and then checks the...

  9. Challenges, Approaches and Experiences from Asian Deltas and the Rhine-Meuse Delta : Regional Training Workshop on Delta Planning and Management

    NARCIS (Netherlands)

    Wosten, J.H.M.; Douven, W.; Long Phi, H.; Fida Abdullah Khan, M.

    2013-01-01

    River delta's, like the Mekong Delta (Vietnam), Ganges-Brahmaputra Delta (Bangladesh), Ayeyarwady Delta (Myanmar), Nile (Egypt) and Ciliwung Delta (Indonesia) are developing rapidly and are characterised by large-scale urbanisation and industrialization processes. They are facing serious planning ch

  10. Deformation characteristics of {delta} phase in the delta-processed Inconel 718 alloy

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, H.Y., E-mail: haiyanzhang@imr.ac.cn [Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016 (China); Zhang, S.H., E-mail: shzhang@imr.ac.cn [Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016 (China); Cheng, M. [Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016 (China); Li, Z.X. [Beijing Institute of Aeronautica1 Materials, Beijing 100095 (China)

    2010-01-15

    The hot working characteristics of {delta} phase in the delta-processed Inconel 718 alloy during isothermal compression deformation at temperature of 950 deg. C and strain rate of 0.005 s{sup -1}, were studied by using optical microscope, scanning electron microscope and quantitative X-ray diffraction technique. The results showed that the dissolution of plate-like {delta} phase and the precipitation of spherical {delta} phase particles coexisted during the deformation, and the content of {delta} phase decreased from 7.05 wt.% to 5.14 wt.%. As a result of deformation breakage and dissolution breakage, the plate-like {delta} phase was spheroidized and transferred to spherical {delta} phase particles. In the center with largest strain, the plate-like {delta} phase disappeared and spherical {delta} phase appeared in the interior of grains and grain boundaries.

  11. Anticancer properties of Monascus metabolites.

    Science.gov (United States)

    Yang, Tao; Liu, Junwen; Luo, Feijun; Lin, Qinlu; Rosol, Thomas J; Deng, Xiyun

    2014-08-01

    This review provides up-to-date information on the anticancer properties of Monascus-fermented products. Topics covered include clinical evidence for the anticancer potential of Monascus metabolites, bioactive Monascus components with anticancer potential, mechanisms of the anticancer effects of Monascus metabolites, and existing problems as well as future perspectives. With the advancement of related fields, the development of novel anticancer Monascus food products and/or pharmaceuticals will be possible with the ultimate goal of decreasing the incidence and mortality of malignancies in humans.

  12. Understanding and classifying metabolite space and Metabolite-Likeness

    NARCIS (Netherlands)

    Peironcely, J.E.; Reijmers, T.; Coulier, L.; Bender, A.; Hankemeier, T.

    2011-01-01

    While the entirety of 'Chemical Space' is huge (and assumed to contain between 1063 and 10200 'small molecules'), distinct subsets of this space can nonetheless be defined according to certain structural parameters. An example of such a subspace is the chemical space spanned by endogenous metabolite

  13. Migration in Deltas: An Integrated Analysis

    Science.gov (United States)

    Nicholls, Robert J.; Hutton, Craig W.; Lazar, Attila; Adger, W. Neil; Allan, Andrew; Arto, Inaki; Vincent, Katharine; Rahman, Munsur; Salehin, Mashfiqus; Sugata, Hazra; Ghosh, Tuhin; Codjoe, Sam; Appeaning-Addo, Kwasi

    2017-04-01

    Deltas and low-lying coastal regions have long been perceived as vulnerable to global sea-level rise, with the potential for mass displacement of exposed populations. The assumption of mass displacement of populations in deltas requires a comprehensive reassessment in the light of present and future migration in deltas, including the potential role of adaptation to influence these decisions. At present, deltas are subject to multiple drivers of environmental change and often have high population densities as they are accessible and productive ecosystems. Climate change, catchment management, subsidence and land cover change drive environmental change across all deltas. Populations in deltas are also highly mobile, with significant urbanization trends and the growth of large cities and mega-cities within or adjacent to deltas across Asia and Africa. Such migration is driven primarily by economic opportunity, yet environmental change in general, and climate change in particular, are likely to play an increasing direct and indirect role in future migration trends. The policy challenges centre on the role of migration within regional adaptation strategies to climate change; the protection of vulnerable populations; and the future of urban settlements within deltas. This paper reviews current knowledge on migration and adaptation to environmental change to discern specific issues pertinent to delta regions. It develops a new integrated methodology to assess present and future migration in deltas using the Volta delta in Ghana, Mahanadi delta in India and Ganges-Brahmaputra-Meghna delta across India and Bangladesh. The integrated method focuses on: biophysical changes and spatial distribution of vulnerability; demographic changes and migration decision-making using multiple methods and data; macro-economic trends and scenarios in the deltas; and the policies and governance structures that constrain and enable adaptation. The analysis is facilitated by a range of

  14. Treatment of Tourette's syndrome with Delta 9-tetrahydrocannabinol (THC): a randomized crossover trial.

    Science.gov (United States)

    Müller-Vahl, K R; Schneider, U; Koblenz, A; Jöbges, M; Kolbe, H; Daldrup, T; Emrich, H M

    2002-03-01

    Anecdotal reports in Tourette's syndrome (TS) have suggested that marijuana (cannabis sativa) and delta-9-tetrahydrocannabinol (Delta(9)-THC), the major psychoactive ingredient of marijuana, reduce tics and associated behavioral disorders. We performed a randomized double-blind placebo-controlled crossover single-dose trial of Delta(9)-THC (5.0, 7.5 or 10.0 mg) in 12 adult TS patients. Tic severity was assessed using a self-rating scale (Tourette's syndrome Symptom List, TSSL) and examiner ratings (Shapiro Tourette's syndrome Severity Scale, Yale Global Tic Severity Scale, Tourette's syndrome Global Scale). Using the TSSL, patients also rated the severity of associated behavioral disorders. Clinical changes were correlated to maximum plasma levels of THC and its metabolites 11-hydroxy-Delta(9)-tetrahydrocannabinol (11-OH-THC) and 11-nor-Delta(9)-tetrahydrocannabinol-9-carboxylic acid (THC-COOH). Using the TSSL, there was a significant improvement of tics (p=0.015) and obsessive-compulsive behavior (OCB) (p = 0.041) after treatment with Delta(9)-THC compared to placebo. Examiner ratings demonstrated a significant difference for the subscore "complex motor tics" (p = 0.015) and a trend towards a significant improvement for the subscores "motor tics" (p = 0.065), "simple motor tics" (p = 0.093), and "vocal tics" (p = 0.093). No serious adverse reactions occurred. Five patients experienced mild, transient side effects. There was a significant correlation between tic improvement and maximum 11-OH-THC plasma concentration. Results obtained from this pilot study suggest that a single-dose treatment with Delta(9)-THC is effective and safe in treating tics and OCB in TS. It can be speculated that clinical effects may be caused by 11-OH-THC. A more long-term study is required to confirm these results.

  15. Casimir force between $\\delta-\\delta^{\\prime}$ mirrors transparent at high frequencies

    CERN Document Server

    Braga, Alessandra N; Alves, Danilo T

    2016-01-01

    We investigate, in the context of a real massless scalar field in $1+1$ dimensions, models of partially reflecting mirrors simulated by Dirac $\\delta-\\delta^{\\prime}$ point interactions. In the literature, these models do not exhibit full transparency at high frequencies. In order to provide a more realistic feature for these models, we propose a modified $\\delta-\\delta^{\\prime}$ point interaction that enables to achieve full transparency in the limit of high frequencies. Taking this modified $\\delta-\\delta^{\\prime}$ model into account, we investigate the Casimir force, comparing our results with those found in the literature.

  16. Evolving deltas: Conceptualising coevolution with engineered interventions

    Science.gov (United States)

    Welch, Amy; Nicholls, Robert; Lazar, Attila

    2017-04-01

    Mid to low latitude deltas have been populated for thousands of years due to their fertile soil and coastal location. This has led to an alteration in the land cover of deltas to primary agriculture and dense rural settlements and more recently, major cities and megacities have developed on or adjacent to many deltas. Deltas may be prosperous in terms of their outputs and services; however, they are also susceptible to many hazards due to their location and low-lying nature. Hazards include storm surges, fluvial flooding and erosion of both coastal and riverine areas, as well as subsidence, relative sea-level rise and pollution. This can have severe impacts on the delta, its population and its services. Therefore engineered interventions have been used for some time to protect the population and the valuable land from the consequences of hazards. Coevolution can be described as a feedback loop between nature and humans: each has an effect on how the other behaves and hence this inter-dependence interaction continues. Therefore the natural evolution of the delta interacts with engineered interventions, such as promoting accelerated subsidence over time, necessitating further adaptation. The deltaic landscape and associated livelihoods are thus the result of this co-evolution process between natural delta processes and engineered interventions. This presentation will identify and discuss various drivers and consequences of large scale engineered interventions, comparing and contrasting the management approaches taken in five populated deltas (Ganges-Brahmaputra-Meghna, Yangtze, Rhine-Meuse-Scheldt, Mekong and Nile). The type of engineered intervention and management approaches had a direct effect on the coevolution of deltas, with each of the deltas being at different stages in terms of extent of coevolution. A qualitative timeline of the typical steps of coevolution between the human system and the delta system of the studied deltas was produced. The major

  17. Primary expectations of secondary metabolites

    Science.gov (United States)

    My program examines the plant secondary metabolites (i.e. phenolics) important for human health, and which impart the organoleptic properties that are quality indicators for fresh and processed foods. Consumer expectations such as appearance, taste, or texture influence their purchasing decisions; a...

  18. The secondary metabolite bioinformatics portal

    DEFF Research Database (Denmark)

    Weber, Tilmann; Kim, Hyun Uk

    2016-01-01

    . In this context, this review gives a summary of tools and databases that currently are available to mine, identify and characterize natural product biosynthesis pathways and their producers based on ‘omics data. A web portal called Secondary Metabolite Bioinformatics Portal (SMBP at http...

  19. Agricultural pesticides in Mississippi Delta oxbow lake sediments during autumn and their effects on Hyalella azteca.

    Science.gov (United States)

    Lizotte, Richard E; Knight, Scott S; Bryant, Charles T; Smith, Sammie

    2009-10-01

    Agricultural pesticide contamination of sediments from five Mississippi Delta oxbow lakes and their effects and bioavailablity to Hyalella azteca were assessed during a low-application season-autumn. Three reference oxbow lakes were located in the White River National Wildlife Refuge (WRNWR), Arkansas and two impaired lakes, according to the US Environmental Agency Sect. 303 (d) Clean Water Act, were located in Mississippi. Surface sediment (top 5 cm) was collected at three sites within each lake and analyzed for 17 current and historic-use pesticides and metabolites. Chronic 28-day H. azteca sediment bioassays and pesticide body residue analyses were completed to determine the degree of biological responses and bioavailability. The greatest number of detectable pesticides in WRNWR and 303 (d) sediment samples was 9 and 12, respectively, with historic-use pesticide metabolite, p,p'-DDE [1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene] ubiquitous. No significant (p > 0.05) differences in animal survival were observed among sites. Animal growth was significantly (p azteca with current-use pesticides detected at three sites; historic-use pesticides and metabolites detected at 11 sites. Animal body residues of a historic-use pesticide (dieldrin) and metabolite (p,p'-DDE) were associated with observed growth responses. Results show limited current-use pesticide contamination of sediments and H. azteca body tissues during autumn and that historic-use pesticides and metabolites are the primary contributors to observed biological responses.

  20. Delta hepatitis agent: structural and antigenic properties of the delta-associated particle.

    Science.gov (United States)

    Bonino, F; Hoyer, B; Shih, J W; Rizzetto, M; Purcell, R H; Gerin, J L

    1984-01-01

    Delta agent (delta) was serially passaged to a second and third hepatitis B surface antigen (HBsAg) carrier chimpanzee, using as inoculum the peak delta antigen (delta Ag) serum of an animal previously infected with human serum. The characteristics of serially transmitted delta Ag were similar to those described in first-passage animals. It was consistently detected before the development of anti-delta, in association with a 35- to 37-nm subpopulation of HBsAg particles and a unique low-molecular-weight (5.5 X 10(5)) RNA. RNase susceptibility of the delta-associated RNA and release of delta Ag activity upon treatment of delta-associated particles with detergent revealed that this particle is organized into a virion-like form with the RNA and delta Ag as internal components within a coat of HBsAg. Surface determinants of the delta-associated particle other than HBsAg were not detected by radioimmunoprecipitation experiments, using sera of humans and chimpanzees convalescent from delta hepatitis. The HBsAg-associated particle is the "candidate agent" of delta hepatitis. Images PMID:6698598

  1. The Niger Delta Amnesty Program

    Directory of Open Access Journals (Sweden)

    Benjamin A. Okonofua

    2016-06-01

    Full Text Available The armed conflict between militias and government forces in Nigeria’s Niger Delta region has spanned for more than two decades, defying all solutions. A disarmament, demobilization, and reintegration (DDR program was established in August 2015 in effort to end the violence and has remained in place. It is a radically different approach from past approaches that displayed zero tolerance to all political challenges to oil production or the allocation of oil profits. The approach appeared to be immediately successful in that it forced a ceasefire, engaged militants in planned programs to rehabilitate and reintegrate them into civilian society, and opened up the oil wells (many of which had been shut due to the crisis with the effect of increasing government revenue, which depends 85% on oil exports. Yet, few studies have attempted to understand the dynamics within the country that are responsible for the design and implementation of this broad policy shift or to understand whether and how the current initiative is able to end the conflict and institute peace beyond the short term. This study, therefore, is important because it provides a critical perspective that anticipates and explains emerging issues with the Niger Delta Amnesty Program, which have implications for DDR adaptation and implementation all over the world. Ultimately, the research demonstrates how the DDR program both transforms the Niger Delta conflict and becomes embroiled in intense contestations not only about the mechanism for transforming the targeted population but also whether and how the program incorporates women who are being deprioritized by the program.

  2. Analysis and Synthesis of Delta Operator Systems

    CERN Document Server

    Yang, Hongjiu; Shi, Peng; Zhao, Ling

    2012-01-01

    This book is devoted to analysis and design on delta operator systems. When sampling is fast, a dynamical system will become difficult to control, which can be seen in wide real world applications. Delta operator approach is very effective to deal with fast sampling systems. Moreover, it is easy to observe and analyze the control effect with different sampling periods in delta operator systems. The framework of this book has been carefully constructed for delta operator systems to handle sliding mode control, time delays, filter design, finite frequency and networked control. These problems indeed are especially important and significant in automation and control systems design. Through the clear framework of the book, readers can easily go through the learning process on delta operator systems via a precise and comfortable learning sequence. Following this enjoyable trail, readers will come out knowing how to use delta operator approach to deal with control problems under fast sampling case. This book should...

  3. Delta Clipper - Design for supportability

    Science.gov (United States)

    Smiljanic, Ray R.; Conrad, Charles; Spaulding, Ed; Gisburne, Don

    1993-07-01

    The 'Delta Clipper' Single Stage Rocket Technology (SSRT) currently under development in the DC-X program will implement reliability-centered maintenance and support, involving on-equipment/off-equipment two-level maintenance, a logistics and spares pipeline, and a minimization of 'blue suit' skill-level personnel. Attention is given to the range of SSRT features that are to be validated via the DC-X test program; these prominently involve LRUs replaceability and accessibility, standardization and interchangeability, and 'aircraft-like' automated data collection.

  4. Climate change and the Delta

    Science.gov (United States)

    Dettinger, Michael; Anderson, Jamie; Anderson, Michael L.; Brown, Larry R.; Cayan, Daniel; Maurer, Edwin P.

    2016-01-01

    Anthropogenic climate change amounts to a rapidly approaching, “new” stressor in the Sacramento–San Joaquin Delta system. In response to California’s extreme natural hydroclimatic variability, complex water-management systems have been developed, even as the Delta’s natural ecosystems have been largely devastated. Climate change is projected to challenge these management and ecological systems in different ways that are characterized by different levels of uncertainty. For example, there is high certainty that climate will warm by about 2°C more (than late-20th-century averages) by mid-century and about 4°C by end of century, if greenhouse-gas emissions continue their current rates of acceleration. Future precipitation changes are much less certain, with as many climate models projecting wetter conditions as drier. However, the same projections agree that precipitation will be more intense when storms do arrive, even as more dry days will separate storms. Warmer temperatures will likely enhance evaporative demands and raise water temperatures. Consequently, climate change is projected to yield both more extreme flood risks and greater drought risks. Sea level rise (SLR) during the 20th century was about 22cm, and is projected to increase by at least 3-fold this century. SLR together with land subsidence threatens the Delta with greater vulnerabilities to inundation and salinity intrusion. Effects on the Delta ecosystem that are traceable to warming include SLR, reduced snowpack, earlier snowmelt and larger storm-driven streamflows, warmer and longer summers, warmer summer water temperatures, and water-quality changes. These changes and their uncertainties will challenge the operations of water projects and uses throughout the Delta’s watershed and delivery areas. Although the effects of climate change on Delta ecosystems may be profound, the end results are difficult to predict, except that native species will fare worse than invaders. Successful

  5. Genetically Encoded Sensors for Metabolites

    Science.gov (United States)

    Deuschle, Karen; Fehr, Marcus; Hilpert, Melanie; Lager, Ida; Lalonde, Sylvie; Looger, Loren L.; Okumoto, Sakiko; Persson, Jörgen; Schmidt, Anja; Frommer, Wolf B.

    2009-01-01

    Background Metabolomics, i.e., the multiparallel analysis of metabolite changes occurring in a cell or an organism, has become feasible with the development of highly efficient mass spectroscopic technologies. Functional genomics as a standard tool helped to identify the function of many of the genes that encode important transporters and metabolic enzymes over the past few years. Advanced expression systems and analysis technologies made it possible to study the biochemical properties of the corresponding proteins in great detail. We begin to understand the biological functions of the gene products by systematic analysis of mutants using systematic PTGS/RNAi, knockout and TILLING approaches. However, one crucial set of data especially relevant in the case of multicellular organisms is lacking: the knowledge of the spatial and temporal profiles of metabolite levels at cellular and subcellular levels. Methods We therefore developed genetically encoded nanosensors for several metabolites to provide a basic set of tools for the determination of cytosolic and subcellular metabolite levels in real time by using fluorescence microscopy. Results Prototypes of these sensors were successfully used in vitro and also in vivo, i.e., to measure sugar levels in fungal and animal cells. Conclusions One of the future goals will be to expand the set of sensors to a wider spectrum of substrates by using the natural spectrum of periplasmic binding proteins from bacteria and by computational design of proteins with altered binding pockets in conjunction with mutagenesis. This toolbox can then be applied for four-dimensional imaging of cells and tissues to elucidate the spatial and temporal distribution of metabolites as a discovery tool in functional genomics, as a tool for high-throughput, high-content screening for drugs, to test metabolic models, and to analyze the interplay of cells in a tissue or organ. PMID:15688353

  6. Metabolite profiles of common Stemphylium species

    DEFF Research Database (Denmark)

    Andersen, Birgitte; Solfrizzo, Michelle; Visconti, Angelo

    1995-01-01

    Thirty-three isolates of Stemphylium spp. have been analysed for their metabolite profiles. Five metabolites, stemphylin, stemphyloxin II, stemphyperylenol, stemphol and a stemphol related compound, have been detected by high-performance liquid chromatography and thin-layer chromatography...

  7. From Natural to Design River Deltas

    Science.gov (United States)

    Giosan, Liviu

    2016-04-01

    Productive and biologically diverse, deltaic lowlands attracted humans since prehistory and may have spurred the emergence of the first urban civilizations. Deltas continued to be an important nexus for economic development across the world and are currently home for over half a billion people. But recently, under the double whammy of sea level rise and inland sediment capture behind dams, they have become the most threatened coastal landscape. Here I will address several deceptively simple questions to sketch some unexpected answers using example deltas from across the world from the Arctic to the Tropics, from the Danube to the Indus, Mississippi to Godavari and Krishna, Mackenzie to Yukon. What is a river delta? What is natural and what is not in a river delta? Are the geological and human histories of a delta important for its current management? Is maintaining a delta the same to building a new one? Can we design better deltas than Nature? These answers help us see clearly that survival of deltas in the next century depends on human intervention and is neither assured nor simple to address or universally applicable. Empirical observations on the hydrology, geology, biology and biochemistry of deltas are significantly lagging behind modeling capabilities endangering the applicability of numerical-based reconstruction solutions and need to be ramped up significantly and rapidly across the world.

  8. Charged current weak electroproduction of $\\Delta$ resonance

    CERN Document Server

    Alvarez-Ruso, L; Vacas, M J V

    1998-01-01

    We study the weak production of $\\Delta$ (i.e. $e^{-} + p \\to \\Delta^{0}+ energy range corresponding to the Mainz and TJNAF electron accelerators. The differential cross sections $\\sigma(\\theta)$ are found to be of the order of $ 10^{-39}$ cm$^2$/sr, over a range of angles which increases with energy. The possibility of observing these reactions with the high luminosities available at these accelerators, and studying the weak N-$\\Delta$ transition form factors through these reactions is discussed. The production cross section of N$^*(1440)$ in the kinematic region of $\\Delta$ production is also estimated and found to be small.

  9. Delta Semantics Defined By Petri Nets

    DEFF Research Database (Denmark)

    Jensen, Kurt; Kyng, Morten; Madsen, Ole Lehrmann

    This report is identical to an earlier version of May 1978 except that Chapter 5 has been revised. A new paper: "A Petri Net Definition of a System Description Language", DAIMI, April 1979, 20 pages, extends the Petri net model to include a data state representing the program variables. Delta...... and the possibility of using predicates to specify state changes. In this paper a formal semantics for Delta is defined and analysed using Petri nets. Petri nets was chosen because the ideas behind Petri nets and Delta concide on several points. A number of proposals for changes in Delta, which resulted from...

  10. SNC 80 and related delta opioid agonists.

    Science.gov (United States)

    Calderon, S N; Coop, A

    2004-01-01

    The discovery of the selective delta (delta) opioid agonists SNC 80 and BW373U86, which possess a diarylmethylpiperazine structure unique among opioids, was a major advance in the field of delta-opioid ligands. Much research has been performed to uncover the structure-activity relationships (SAR) of this class of ligands and also to compare the diarylmethylpiperazines with the traditional morphinan-based delta opioids. This review focuses on the development of the SAR of this unique series of ligands, and discusses questions which remain unanswered.

  11. Pharmacokinetics of Tyrosol Metabolites in Rats

    OpenAIRE

    Da-Hye Lee; Yang-Ji Kim; Min Jung Kim; Jiyun Ahn; Tae-Youl Ha; Sang Hee Lee; Young Jin Jang; Chang Hwa Jung

    2016-01-01

    Tyrosol is considered a potential antioxidant; however, little is known regarding the pharmacokinetics of its metabolites. To study the pharmacokinetics of tyrosol-derived metabolites after oral administration of a single dose of tyrosol, we attempted to identify tyrosol metabolites in rat plasma by using ultra-performance liquid chromatography and quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS). Two tyrosol metabolites (M1 and M2) were detected in the plasma. M1 was identified as...

  12. $\\Delta$ decay in nuclear medium

    CERN Document Server

    Jain, B K; Kundu, Bijoy

    1996-01-01

    Proton-nucleus collisions, where the beam proton gets excited to the delta resonance and then decays to p\\pi ^+, either inside or outside the nuclear medium, are studied. Cross-sections for various kinematics for the (p,p' \\pi ^+) reaction between 500 MeV and 1 GeV beam energy are calculated to see the effects of the nuclear medium on the propagation and decay of the resonance. The cross-sections studied include proton energy spectra in coincidence with the pion, four momentum transfer distributions, and the invariant p\\pi^+ mass distributions. We find that the effect of the nuclear medium on these cross-sections mainly reduces their magnitudes. Comparing these cross-sections with those considering the decay of the delta outside the nucleus only, we further find that at 500 MeV the two sets of cross-sections have large differences, while by 1 GeV the differences between them become much smaller.

  13. Comparative assessment of the vulnerability and resilience of deltas : extended version with 14 deltas : synthesis report

    NARCIS (Netherlands)

    Bucx, T.; Driel, van W.F.; Boer, de H.; Graas, S.; Langenberg, V.; Marchand, M.; Guchte, van de C.

    2014-01-01

    Worldwide, deltas host dense populations and are important centres of agricultural and industrial production, and economic activity. Many deltas are areas of great ecological importance as well, featuring wetlands of high and unique biodiversity. Deltas are vulnerable to changes by natural forces an

  14. $\\Delta I=4$ and $\\Delta I=8$ bifurcations in rotational bands of diatomic molecules

    CERN Document Server

    Bonatsos, Dennis; Lalazissis, G A; Drenska, S B; Minkov, N; Raychev, P P; Roussev, R P; Bonatsos, Dennis

    1996-01-01

    It is shown that the recently observed $\\Delta I=4$ bifurcation seen in superdeformed nuclear bands is also occurring in rotational bands of diatomic molecules. In addition, signs of a $\\Delta I=8$ bifurcation, of the same order of magnitude as the $\\Delta I=4$ one, are observed both in superdeformed nuclear bands and rotational bands of diatomic molecules.

  15. INFLUENCE OF THE DELTA-DELTA-MESON COUPLING ON NUCLEON AND DELTA PROPERTIES IN NUCLEAR-MATTER

    NARCIS (Netherlands)

    DEJONG, F; MALFLIET, R

    1994-01-01

    We introduce a scalar and a vector DELTADELTA-meson vertex in the relativistic Dirac-Brueckner model for nuclear matter and investigate the consequences. We find small effects on the effective nucleon properties. The effects in the DELTA sector are more profound, although the DELTA is still effectiv

  16. 10 CFR 26.163 - Cutoff levels for drugs and drug metabolites.

    Science.gov (United States)

    2010-01-01

    ... metabolites Cutoff level Marijuana metabolites 50 Cocaine metabolites 300 Opiate metabolites 2000... Levels for Drugs and Drug Metabolites Drug or metabolites Cutoff level(ng/mL) Marijuana metabolite 1...

  17. Fungal metabolites with anticancer activity.

    Science.gov (United States)

    Evidente, Antonio; Kornienko, Alexander; Cimmino, Alessio; Andolfi, Anna; Lefranc, Florence; Mathieu, Véronique; Kiss, Robert

    2014-05-01

    Covering: 1964 to 2013. Natural products from bacteria and plants have played a leading role in cancer drug discovery resulting in a large number of clinically useful agents. In contrast, the investigations of fungal metabolites and their derivatives have not led to a clinical cancer drug in spite of significant research efforts revealing a large number of fungi-derived natural products with promising anticancer activity. Many of these natural products have displayed notable in vitro growth-inhibitory properties in human cancer cell lines and select compounds have been demonstrated to provide therapeutic benefits in mouse models of human cancer. Many of these compounds are expected to enter human clinical trials in the near future. The present review discusses the reported sources, structures and biochemical studies aimed at the elucidation of the anticancer potential of these promising fungal metabolites.

  18. Secondary metabolites from Eremostachys laciniata

    DEFF Research Database (Denmark)

    Calis, Ihsan; Güvenc, Aysegül; Armagan, Metin;

    2008-01-01

    From the aerial parts of Eremostachys laciniata (Lamiaceae), a new acidic iridoid glucoside, 5-desoxysesamosidic acid (1) was isolated in addition to thirteen known iridoid glucosides, 5-desoxysesamoside (2), sesamoside (3), 6β-hydroxy-7-epi-loganin (4), chlorotuberoside (5), 5-deoxypulchelloside...... elucidated from spectroscopic (UV, IR, 1D- and 2D-NMR) and ESI-MS evidence, as well as from their specific optical rotation. The presence of these metabolites of three different classes strongly supports the close relationship of the genera Eremostachys and Phlomis.......), and forsythoside B (18), and five flavone derivatives, luteolin (19), luteolin 7-O-β-D-glucopyranoside (20), luteolin 7-O-(6''-O-β-D-apiofuranosyl)-β-D-glucopyranoside (21), apigenin 7-O-β-D-glucopyranoside (22), and apigenin 7-O-(6''-O-p-coumaroyl)-β-D-glucopyranoside (23). The structures of the metabolites were...

  19. Electromagnetic excitation of the Delta(1232) resonance

    Energy Technology Data Exchange (ETDEWEB)

    V. Pascalutsa; M. Vanderhaeghen; Shin Nan Yang

    2006-09-05

    We review the description of the lowest-energy nucleon excitation--the Delta(1232)-resonance. Much of the recent effort has been focused on the precision measurements of the nucleon to Delta transition by means of electromagnetic probes. We review the results of those measurements and confront them with the state-of-the-art calculations based on chiral effective-field theories (EFT), lattice QCD, and QCD-inspired models. Some of the theoretical approaches are reviewed in detail. In particular, we describe the chiral EFT of QCD in the energy domain of the Delta-resonance, and its applications to the electromagnetic nucleon-to-Delta transition (gamma N Delta). We also describe the recent dynamical and unitary-isobar models of pion electroproduction which are extensively used in the extraction of the gamma* N Delta form factors from experiment. Furthermore, we discuss the link of the gamma* N Delta form factors to generalized parton distributions (GPDs), as well as the predictions of perturbative QCD for these transition form factors. The present status of understanding the Delta-resonance properties and the nature of its excitation is summarized.

  20. Structure and replication of hepatitis delta virus

    African Journals Online (AJOL)

    STORAGESEVER

    2008-12-29

    Dec 29, 2008 ... Unidade de Biologia Molecular, Centro de Malária e outras Doenças Tropicais, Instituto de Higiene e Medicina Tropical, ... molecules of both delta antigens (Ryu et al., 1993). This ..... Glenn JS, Watson JA, Havel CM, White JO (1992). ... HDV RNA encoding the large delta antigen cannot replicate. J. Gen.

  1. Generalised CP and $\\Delta (96)$ Family Symmetry

    CERN Document Server

    Ding, Gui-Jun

    2014-01-01

    We perform a comprehensive study of the $\\Delta (96)$ family symmetry combined with the generalised CP symmetry $H_{\\rm{CP}}$. We investigate the lepton mixing parameters which can be obtained from the original symmetry $\\Delta (96)\\rtimes H_{\\rm{CP}}$ breaking to different remnant symmetries in the neutrino and charged lepton sectors, namely $G_{\

  2. Delta Blues Scholarship and Imperialist Nostalgia.

    Science.gov (United States)

    Nye, William P.

    When Delta blues are considered to be "folk music," the genre is inextricably tied to the neocolonial, sharecropping system of cotton production characteristic of the Mississippi Delta region between the Civil War and World War II. "Imperialist nostalgia," then, arises in accounts which pay primary and positive tribute to blues…

  3. The delta opioid receptor tool box.

    Science.gov (United States)

    Vicente-Sanchez, Ana; Segura, Laura; Pradhan, Amynah A

    2016-12-03

    In recent years, the delta opioid receptor has attracted increasing interest as a target for the treatment of chronic pain and emotional disorders. Due to their therapeutic potential, numerous tools have been developed to study the delta opioid receptor from both a molecular and a functional perspective. This review summarizes the most commonly available tools, with an emphasis on their use and limitations. Here, we describe (1) the cell-based assays used to study the delta opioid receptor. (2) The features of several delta opioid receptor ligands, including peptide and non-peptide drugs. (3) The existing approaches to detect delta opioid receptors in fixed tissue, and debates that surround these techniques. (4) Behavioral assays used to study the in vivo effects of delta opioid receptor agonists; including locomotor stimulation and convulsions that are induced by some ligands, but not others. (5) The characterization of genetically modified mice used specifically to study the delta opioid receptor. Overall, this review aims to provide a guideline for the use of these tools with the final goal of increasing our understanding of delta opioid receptor physiology.

  4. Entendiendo Delta desde las Humanidades

    Directory of Open Access Journals (Sweden)

    José Calvo Tello

    2016-05-01

    Full Text Available Stylometry is one of the research areas in greater development within Digital Humanities. However, few studies have worked until recently with texts in Spanish and even less so from Spanish-speaking countries. The aim of this paper is to present in Spanish, and without prior statistical knowledge from the reader, one of the main methods used in stylometry, the measure of textual distance Burrows’ Delta. This paper explains this measure using a very small corpus of proverbs and then checks the results in a corpus of Spanish novels. Both data and Python scripts are available to the community through GitHub, commented step by step so that you can play and visualize each step.

  5. Jiaxing: Delicacy of the Yangtze River Delta

    Institute of Scientific and Technical Information of China (English)

    WUXINYI; WANGNAN

    2004-01-01

    THE yangtze River Delta,where the Yangtzc River crosses China's east coast,has one of the country's most dynamic economies.In 1976Jcan Gottmann.a french geographer,called shanghai and its neighboring Yangtze River Delta the world's "sixth largest megalopolis." The Yangtze River Delta has 15 cities. Its territory accounts for one percent of China's total, 5.8 percent of hthe population, and 19.5 percent of the national GDP.In terms of both aggregate economy and growth speed, the Delta currently leads China and could likely be the "enginc" of the world's future economic growth. Located at the juncition of Shanghai Jiangsu and Zhejiang, Jiaxing City holds a central economic belt. It is within 100 kilometers of Shanghai, Hangzhou and Suzhou. In 200 and 2003, Jiaxing's GDP growth rate was first in Zhejiang Province and second among the 1.5 Delta cities.

  6. A review of environmental and human exposure to persistent organic pollutants in the Pearl River Delta, South China.

    Science.gov (United States)

    Zhang, Kai; Wei, Yan-Li; Zeng, Eddy Y

    2013-10-01

    Rapid economic growth in South China (including Guangdong Province, Hong Kong, and Macau), particularly within the Pearl River Delta region, has resulted in severe pollution of the natural eco-environment in the last three decades. Large amounts of monitoring data on organic pollution in the Pearl River Delta have been accumulated, which allows us to conduct a fairly comprehensive assessment of the state of the Pearl River Delta and elucidate spatial and temporal patterns of pollution on a regional scale. Of various causes for environmental deterioration, negative impact from persistent organic pollutants (POPs) is a global concern. This review examines the current levels and distribution patterns of several POPs, namely DDT (and its metabolites DDD and DDE), hexachlorocyclohexanes, and polybrominated diphenyl ethers, in various environmental compartments of South China. The general information on environmental occurrence, regional behaviors, ecological effects, and human exposure of these POPs in this region are reviewed.

  7. Metabolite

    Science.gov (United States)

    Kumar V, Abbas AK, Aster JC. Cellular responses to stress and toxic insults: Adaptation, injury, and death. In: Kumar V, Abbas AK, Aster JC, eds. Robbins and Cotran Pathologic Basis of Disease . 9th ed. Philadelphia, PA: ...

  8. Differentiation of Boc-protected alpha,delta-/delta,alpha- and beta,delta-/delta,beta-hybrid peptide positional isomers by electrospray ionization tandem mass spectrometry.

    Science.gov (United States)

    Raju, G; Ramesh, V; Srinivas, R; Sharma, G V M; Shoban Babu, B

    2010-06-01

    Two new series of Boc-N-alpha,delta-/delta,alpha- and beta,delta-/delta,beta-hybrid peptides containing repeats of L-Ala-delta(5)-Caa/delta(5)-Caa-L-Ala and beta(3)-Caa-delta(5)-Caa/delta(5)-Caa-beta(3)-Caa (L-Ala = L-alanine, Caa = C-linked carbo amino acid derived from D-xylose) have been differentiated by both positive and negative ion electrospray ionization (ESI) ion trap tandem mass spectrometry (MS/MS). MS(n) spectra of protonated isomeric peptides produce characteristic fragmentation involving the peptide backbone, the Boc-group, and the side chain. The dipeptide positional isomers are differentiated by the collision-induced dissociation (CID) of the protonated peptides. The loss of 2-methylprop-1-ene is more pronounced for Boc-NH-L-Ala-delta-Caa-OCH(3) (1), whereas it is totally absent for its positional isomer Boc-NH-delta-Caa-L-Ala-OCH(3) (7), instead it shows significant loss of t-butanol. On the other hand, second isomeric pair shows significant loss of t-butanol and loss of acetone for Boc-NH-delta-Caa-beta-Caa-OCH(3) (18), whereas these are insignificant for its positional isomer Boc-NH-beta-Caa-delta-Caa-OCH(3) (13). The tetra- and hexapeptide positional isomers also show significant differences in MS(2) and MS(3) CID spectra. It is observed that 'b' ions are abundant when oxazolone structures are formed through five-membered cyclic transition state and cyclization process for larger 'b' ions led to its insignificant abundance. However, b(1)(+) ion is formed in case of delta,alpha-dipeptide that may have a six-membered substituted piperidone ion structure. Furthermore, ESI negative ion MS/MS has also been found to be useful for differentiating these isomeric peptide acids. Thus, the results of MS/MS of pairs of di-, tetra-, and hexapeptide positional isomers provide peptide sequencing information and distinguish the positional isomers.

  9. Influence of different organic fertilizers on quality parameters and the delta(15)N, delta(13)C, delta(2)H, delta(34)S, and delta(18)O values of orange fruit (Citrus sinensis L. Osbeck).

    Science.gov (United States)

    Rapisarda, Paolo; Camin, Federica; Fabroni, Simona; Perini, Matteo; Torrisi, Biagio; Intrigliolo, Francesco

    2010-03-24

    To investigate the influence of different types of fertilizers on quality parameters, N-containing compounds, and the delta(15)N, delta(13)C, delta(2)H, delta (34)S, and delta(18)O values of citrus fruit, a study was performed on the orange fruit cv. 'Valencia late' (Citrus sinensis L. Osbeck), which was harvested in four plots (three organic and one conventional) located on the same farm. The results demonstrated that different types of organic fertilizers containing the same amount of nitrogen did not effect important changes in orange fruit quality parameters. The levels of total N and N-containing compounds such as synephrine in fruit juice were not statistically different among the different treatments. The delta(15)N values of orange fruit grown under fertilizer derived from animal origin as well as from vegetable compost were statistically higher than those grown with mineral fertilizer. Therefore, delta(15)N values can be used as an indicator of citrus fertilization management (organic or conventional), because even when applied organic fertilizers are of different origins, the natural abundance of (15)N in organic citrus fruit remains higher than in conventional ones. These treatments also did not effect differences in the delta(13)C, delta(2)H, delta(34)S, and delta(18)O values of fruit.

  10. Identifying hazards associated with lava deltas

    Science.gov (United States)

    Poland, Michael P.; Orr, Tim R.

    2014-01-01

    Lava deltas, formed where lava enters the ocean and builds a shelf of new land extending from the coastline, represent a significant local hazard, especially on populated ocean island volcanoes. Such structures are unstable and prone to collapse—events that are often accompanied by small explosions that can deposit boulders and cobbles hundreds of meters inland. Explosions that coincide with collapses of the East Lae ‘Apuki lava delta at Kīlauea Volcano, Hawai‘i, during 2005–2007 followed an evolutionary progression mirroring that of the delta itself. A collapse that occurred when the lava–ocean entry was active was associated with a blast of lithic blocks and dispersal of spatter and fine, glassy tephra. Shortly after delta growth ceased, a collapse exposed hot rock to cold ocean water, resulting in an explosion composed entirely of lithic blocks and lapilli. Further collapse of the delta after several months of inactivity, by which time it had cooled significantly, resulted in no recognizable explosion deposit. Seaward displacement and subsidence of the coastline immediately inland of the delta was measured by both satellite and ground-based sensors and occurred at rates of several centimeters per month even after the lava–ocean entry had ceased. The anomalous deformation ended only after complete collapse of the delta. Monitoring of ground deformation may therefore provide an indication of the potential for delta collapse, while the hazard associated with collapse can be inferred from the level of activity, or the time since the last activity, on the delta.

  11. Epigenome targeting by probiotic metabolites

    Directory of Open Access Journals (Sweden)

    Licciardi Paul V

    2010-12-01

    Full Text Available Abstract Background The intestinal microbiota plays an important role in immune development and homeostasis. A disturbed microbiota during early infancy is associated with an increased risk of developing inflammatory and allergic diseases later in life. The mechanisms underlying these effects are poorly understood but are likely to involve alterations in microbial production of fermentation-derived metabolites, which have potent immune modulating properties and are required for maintenance of healthy mucosal immune responses. Probiotics are beneficial bacteria that have the capacity to alter the composition of bacterial species in the intestine that can in turn influence the production of fermentation-derived metabolites. Principal among these metabolites are the short-chain fatty acids butyrate and acetate that have potent anti-inflammatory activities important in regulating immune function at the intestinal mucosal surface. Therefore strategies aimed at restoring the microbiota profile may be effective in the prevention or treatment of allergic and inflammatory diseases. Presentation of the hypothesis Probiotic bacteria have diverse effects including altering microbiota composition, regulating epithelial cell barrier function and modulating of immune responses. The precise molecular mechanisms mediating these probiotic effects are not well understood. Short-chain fatty acids such as butyrate are a class of histone deacetylase inhibitors important in the epigenetic control of host cell responses. It is hypothesized that the biological function of probiotics may be a result of epigenetic modifications that may explain the wide range of effects observed. Studies delineating the effects of probiotics on short-chain fatty acid production and the epigenetic actions of short-chain fatty acids will assist in understanding the association between microbiota and allergic or autoimmune disorders. Testing the hypothesis We propose that treatment with

  12. Radioligand-binding study of noribogaine, a likely metabolite of ibogaine.

    Science.gov (United States)

    Pearl, S M; Herrick-Davis, K; Teitler, M; Glick, S D

    1995-03-27

    Radioligand-binding studies were performed to ascertain the actions of noribogaine, a suspected metabolite of ibogaine, on opioid receptors. Consistent with previous results, ibogaine showed highest affinity for kappa opioid receptors (Ki = 3.77 +/- 0.81 microM), less affinity for mu receptors (Ki = 11.04 +/- 0.66 microM) and no affinity for delta receptors (Ki > 100 microM). Noribogaine showed a higher affinity than ibogaine for all of the opioid receptors: kappa Ki = 0.96 +/- 0.08 microM, mu Ki = 2.66 +/- 0.62 microM and delta Ki = 24.72 +/- 2.26 microM. These data suggest that noribogaine is active in vivo and that it may contribute to ibogaine's pharmacological effects.

  13. Delta Electroproduction in 12-C

    Energy Technology Data Exchange (ETDEWEB)

    McLauchlan, Steven [Univ. of Glasgow, Scotland (United Kingdom)

    2003-01-01

    The Δ-nucleus potential is a crucial element in the understanding of the nuclear system. Previous electroexcitation measurements in the delta region reported a Q2 dependence of the Δ mass indicating that this potential is dependent on the momentum of the Δ. Such a dependence is not observed for protons and neutrons in the nuclear medium. This thesis presents the experimental study of the electroexcitation of the Δ resonance in 12C, performed using the high energy electron beam at the Thomas Jefferson National Accelerator Facility, and the near 4π acceptance detector CLAS that enables the detection of the full reaction final state. Inclusive, semi inclusive, and exclusive cross sections were measured with an incident electron beam energy of 1.162GeV over the Q2 range 0.175-0.475 (GeV/c)2. A Q2 dependence of the Δ mass was only observed in the exclusive measurements indicating that the Δ-nucleus potential is affected by the momentum of the Δ.

  14. Novel diazabicycloalkane delta opioid agonists.

    Science.gov (United States)

    Loriga, Giovanni; Lazzari, Paolo; Manca, Ilaria; Ruiu, Stefania; Falzoi, Matteo; Murineddu, Gabriele; Bottazzi, Mirko Emilio Heiner; Pinna, Giovanni; Pinna, Gérard Aimè

    2015-09-01

    Here we report the investigation of diazabicycloalkane cores as potential new scaffolds for the development of novel analogues of the previously reported diazatricyclodecane selective delta (δ) opioid agonists, as conformationally constrained homologues of the reference δ agonist (+)-4-[(αR)-α((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide (SNC80). In particular, we have simplified the diazatricyclodecane motif of δ opioid agonist prototype 1a with bridged bicyclic cores. 3,6-diazabicyclo[3.1.1]heptane, 3,8-diazabicyclo[3.2.1]octane, 3,9-diazabicyclo[3.3.1]nonane, 3,9-diazabicyclo[4.2.1]nonane, and 3,10-diazabicyclo[4.3.1]decane were adopted as core motifs of the novel derivatives. The compounds were synthesized and biologically assayed as racemic (3-5) or diastereoisomeric (6,7) mixtures. All the novel compounds 3-7 showed δ agonism behaviour and remarkable affinity to δ receptors. Amongst the novel derivatives, 3,8-diazabicyclo[3.2.1]octane based compound 4 evidenced improved δ affinity and selectivity relative to SNC80. Published by Elsevier Ltd.

  15. Metabolite Profiling of Red Sea Corals

    KAUST Repository

    Ortega, Jovhana Alejandra

    2016-12-01

    Looking at the metabolite profile of an organism provides insights into the metabolomic state of a cell and hence also into pathways employed. Little is known about the metabolites produced by corals and their algal symbionts. In particular, corals from the central Red Sea are understudied, but interesting study objects, as they live in one of the warmest and most saline environments and can provide clues as to the adjustment of corals to environmental change. In this study, we applied gas chromatography – mass spectrometry (GC–MS) metabolite profiling to analyze the metabolic profile of four coral species and their associated symbionts: Fungia granulosa, Acropora hemprichii, Porites lutea, and Pocillopora verrucosa. We identified and quantified 102 compounds among primary and secondary metabolites across all samples. F. granulosa and its symbiont showed a total of 59 metabolites which were similar to the 51 displayed by P. verrucosa. P. lutea and A. hemprichii both harbored 40 compounds in conjunction with their respective isolated algae. Comparing across species, 28 metabolites were exclusively present in algae, while 38 were exclusive to corals. A principal component and cluster analyses revealed that metabolite profiles clustered between corals and algae, but each species harbored a distinct catalog of metabolites. The major classes of compounds were carbohydrates and amino acids. Taken together, this study provides a first description of metabolites of Red Sea corals and their associated symbionts. As expected, the metabolites of coral hosts differ from their algal symbionts, but each host and algal species harbor a unique set of metabolites. This corroborates that host-symbiont species pairs display a fine-tuned complementary metabolism that provide insights into the specific nature of the symbiosis. Our analysis also revealed aquatic pollutants, which suggests that metabolite profiling might be used for monitoring pollution levels and assessing

  16. GPCR-Mediated Signaling of Metabolites

    DEFF Research Database (Denmark)

    Husted, Anna Sofie; Trauelsen, Mette; Rudenko, Olga

    2017-01-01

    in adipose tissue, the liver, and the endocrine pancreas. Importantly, distinct metabolite GPCRs act as efficient pro- and anti-inflammatory regulators of key immune cells, and signaling metabolites may thus function as important drivers of the low-grade inflammation associated with insulin resistance...... and obesity. The concept of key metabolites as ligands for specific GPCRs has broadened our understanding of metabolic signaling significantly and provides a number of novel potential drug targets....

  17. Metabolites from Alternaria Fungi and Their Bioactivities

    Directory of Open Access Journals (Sweden)

    Ligang Zhou

    2013-05-01

    Full Text Available Alternaria is a cosmopolitan fungal genus widely distributing in soil and organic matter. It includes saprophytic, endophytic and pathogenic species. At least 268 metabolites from Alternaria fungi have been reported in the past few decades. They mainly include nitrogen-containing metabolites, steroids, terpenoids, pyranones, quinones, and phenolics. This review aims to briefly summarize the structurally different metabolites produced by Alternaria fungi, as well as their occurrences, biological activities and functions. Some considerations related to synthesis, biosynthesis, production and applications of the metabolites from Alternaria fungi are also discussed.

  18. Damped Oscillator with Delta-Kicked Frequency

    Science.gov (United States)

    Manko, O. V.

    1996-01-01

    Exact solutions of the Schrodinger equation for quantum damped oscillator subject to frequency delta-kick describing squeezed states are obtained. The cases of strong, intermediate, and weak damping are investigated.

  19. Delta-nucleus dynamics: proceedings of symposium

    Energy Technology Data Exchange (ETDEWEB)

    Lee, T.S.H.; Geesaman, D.F.; Schiffer, J.P. (eds.)

    1983-10-01

    The appreciation of the role in nuclear physics of the first excited state of the nucleon, the delta ..delta..(1232), has grown rapidly in the past decade. The delta resonance dominates nuclear reactions induced by intermediate energy pions, nucleons, and electromagnetic probes. It is also the most important non-nucleonic degree of freedom needed to resolve many fundamental problems encountered in the study of low-energy nuclear phenomena. Clearly, a new phase of nuclear physics has emerged and conventional thinking must be extended to account for this new dimension of nuclear dynamics. The most challenging problem we are facing is how a unified theory can be developed to describe ..delta..-nucleus dynamics at all energies. In exploring this new direction, it is important to have direct discussions among researchers with different viewpoints. Separate entries were prepared for the 49 papers presented. (WHK)

  20. in the Niger Delta of Nigeria

    African Journals Online (AJOL)

    suggestions as policy options for the resolution of the armed conflict in the. Niger Delta ... indiscriminate use of lethal weapons by local militias, the cumulative effect of which is the ... of many 'child' soldiers in local conflicts or wars nowadays.

  1. Contemporary depositional environments of the Omo delta.

    Science.gov (United States)

    Butzer, K W

    1970-05-02

    Geomorphological and sedimentological studies of depositional environments of the modern Omo River delta and floodplain are essential to an understanding of the Pliocene to Pleistocene Mursi, Nkalabong and Kibish Formations of the Lower Omo Basin (southwestern Ethiopia).

  2. Legal Delta Boundary, 2001, DWR [ds586

    Data.gov (United States)

    California Department of Resources — The original topographic maps containing the drawn delta border were scanned from the Department of Water Resources. Images were registered to 1:24,000 USGS DRG's in...

  3. Cackling Canada goose nesting populations, Yukon Delta

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Number of potential territories, number of cackling Canada Goose nests, and percent occupancy of available territories from CCG plots on the Yukon Delta National...

  4. Water quality in the Okavango Delta

    African Journals Online (AJOL)

    2010-03-12

    Mar 12, 2010 ... water and sediments in the Okavango Delta published between 2000 and 2010. Despite the shortage ... Their interactions with light, water, dissolved nutrients and suspended solids ...... temporal remote sensing. Int. J. Remote ...

  5. California Black Rail - Central Delta [ds17

    Data.gov (United States)

    California Department of Resources — Results of taped-call black rail surveys of in-stream habitat within certain waterways in the central Sacramento / San Joaquin Delta during 1992 and 1993. TIME...

  6. Propagator for the double delta potential

    Energy Technology Data Exchange (ETDEWEB)

    Cacciari, Ilaria [Istituto di Fisica Applicata ' Nello Carrara' , CNR, via Madonna del Piano 10, 50019 Sesto Fiorentino, Florence (Italy); Moretti, Paolo [Istituto dei Sistemi Complessi, CNR, Sezione di Firenze, via Madonna del Piano 10, 50019 Sesto Fiorentino, Florence (Italy)]. E-mail: paolo.moretti@isc.cnr.it

    2006-12-04

    The propagator for the double delta potential is calculated starting from the integral form of the Schroedinger equation. A compact expression of its Laplace transform is found, that can be explicitly inverted in some limiting cases.

  7. The Atchafalaya River Delta. Report 4. Generic Analysis of Delta Development.

    Science.gov (United States)

    1984-01-01

    contemporaneously with delta growth (Donaldson, Martin , and Kanes 1970). The average rate of contour advancement has been ap- proximately 12 m/yr. Assuming the...Donaldson, Martin , ’, and Kanes 1970) shows that the delta has transgressed over 60 m. Average rates of deterioration are reported to be 2.75 m/yr...after 1965 ( Keown , Dardeau, and Causey 1980). Coarse sediment not reaching the delta is precisely the material needed for subaerial land. Third, the

  8. Optimized $\\delta$ expansion for relativistic nuclear models

    CERN Document Server

    Krein, G I; Peres-Menezes, D; Nielsen, M; Pinto, M B

    1998-01-01

    The optimized $\\delta$-expansion is a nonperturbative approach for field theoretic models which combines the techniques of perturbation theory and the variational principle. This technique is discussed in the $\\lambda \\phi^4$ model and then implemented in the Walecka model for the equation of state of nuclear matter. The results obtained with the $\\delta$ expansion are compared with those obtained with the traditional mean field, relativistic Hartree and Hartree-Fock approximations.

  9. Migration in Vulnerable Deltas: A Research Strategy

    Science.gov (United States)

    Hutton, C.; Nicholls, R. J.; Allan, A.

    2015-12-01

    C. Hutton1, & R. J. Nicholls1, , 1 University of Southampton, University Road, Southampton, Hampshire, United Kingdom, SO17 1BJ. cwh@geodata. soton.ac.ukAbstractGlobally, deltas contain 500 million people and with rising sea levels often linked to large number of forced migrants are expected in the coming century. However, migration is already a major process in deltas, such as the growth of major cities such as Dhaka and Kolkata. Climate and environmental change interacts with a range of catchment and delta level drivers, which encompass a nexus of sea-level rise, storms, freshwater and sediment supply from the catchment, land degradation, subsidence, agricultural loss and socio-economic stresses. DECCMA (Deltas, Vulnerability and Climate Change: Migration and Adaptation/CARRIA) is investigating migration in the Ganges-Brahmaputra-Meghna (GBM), Mahanadi and Volta Deltas, including the influence of climate change. The research will explore migration from a range of perspectives including governance and stakeholder analysis, demographic analysis, household surveys of sending and receiving areas, macro-economic analysis, and hazards and hotspot analysis both historically and into the future. Migration under climate change will depend on other adaptation in the deltas and this will be examined. Collectively, integrated analysis will be developed to examine migration, other adaptation and development pathways with a particular focus on the implications for the poorest. This will require the development of input scenarios, including expert-derived exogenous scenarios (e.g., climate change) and endogenous scenarios of the delta developed in a participatory manner. This applied research will facilitate decision support methods for the development of deltas under climate change, with a focus on migration and other adaptation strategies.

  10. Stellar delta matter with delta-meson coupling constants constrained by QCD sum rule

    Energy Technology Data Exchange (ETDEWEB)

    Silva, Antonio Ferreira da [Secretaria de Educacao, Cultura e Desportos do Estado de Roraima (SECD/RR), Boa Vista, RR (Brazil); Oliveira, Jose Carlos Teixeira de [Universidade Federal de Roraima (UFRR), Boa Vista, RR (Brazil); Rodrigues, Hilario [Centro Federal de Educacao Tecnologica (CEFET-RJ), Rio de Janeiro, RJ (Brazil); Duarte, Sergio Barbosa [Centro Brasileiro de Pesquisas Fisicas (CBPF), Rio de Janeiro, RJ (Brazil); Chiapparini, Marcelo [Universidade do Estado do Rio de Janeiro (UERJ), RJ (Brazil)

    2010-07-01

    The considerable presence of delta-resonances (30% of baryonic population) in the dense phase of relativistic heavy ion collisions leads to a great interest in the study of the delta matter formation in the deep interior of compact stars. In the present work we determine the equation of state and the population of baryons and leptons and discuss the effects of the baryon-meson coupling constants to the formation of delta matter in the stellar medium. We use the non-linear Walecka model consisting of the octet of baryons of spin 1=2 (n, p, {Lambda}{sup 0}, {Sigma}{sup -}, {Sigma}{sup 0}, {Sigma}{sup +}, {Xi}{sup -}, {Xi}{sup 0}) and baryonic resonances of spin 3=2, represented by the delta resonances ({Delta}{sup -}, ({Delta}{sup 0}, ({Delta}{sup +}, ({Delta}{sup ++}) and {Omega}{sup -}, in the baryonic sector. In the leptonic sector we consider the electrons and muons. The coupling constants between the hyperons {Lambda}, {Sigma}, and {Xi} and the mesons {omega} and {rho} are fixed by using SU(6) symmetry, while the hyperons-{sigma} coupling constants are constrained by the consistence of the hypernuclear potential in the nuclear matter with hypernuclear data. In addition, we use the finite density QCD sum rule to determine the possible values of delta-meson coupling constants. (author)

  11. delta(13)C and delta(2)H isotope ratios in amphetamine synthesized from benzaldehyde and nitroethane.

    Science.gov (United States)

    Collins, Michael; Salouros, Helen; Cawley, Adam T; Robertson, James; Heagney, Aaron C; Arenas-Queralt, Andrea

    2010-06-15

    Previous work in these laboratories and by Butzenlechner et al. and Culp et al. has demonstrated that the delta(2)H isotope value of industrial benzaldehyde produced by the catalytic oxidation of toluene is profoundly positive, usually in the range +300 per thousand to +500 per thousand. Synthetic routes leading to amphetamine, methylamphetamine or their precursors and commencing with such benzaldehyde may be expected to exhibit unusually positive delta(2)H values. Results are presented for delta(13)C and delta(2)H isotope values of 1-phenyl-2-nitropropene synthesized from an industrial source of benzaldehyde, having a positive delta(2)H isotope value, by a Knoevenagel condensation with nitroethane. Results are also presented for delta(13)C and delta(2)H isotope values for amphetamine prepared from the resulting 1-phenyl-2-nitropropene. The values obtained were compared with delta(13)C and delta(2)H isotope values obtained for an amphetamine sample prepared using a synthetic route that did not involve benzaldehyde. Finally, results are presented for samples of benzaldehyde, 1-phenyl-2-nitropropene and amphetamine that had been seized at a clandestine amphetamine laboratory.

  12. Radiosynthesis and in vivo evaluation of the pseudopeptide {delta}-opioid antagonist [{sup 125}I]-ITIPP({psi})

    Energy Technology Data Exchange (ETDEWEB)

    Collier, T.L. E-mail: TC311@columbia.edu; Schiller, P.W.; Waterhouse, R.N

    2001-05-01

    The radioiodinated tetrapeptide {delta}-opioid antagonist [{sup 125}I]ITIPP({psi}) [H-Tyr(3'I)-Tic{psi}[CH{sub 2}NH]Phe-Phe-OH] (Ki({delta}) 2.08 nM; Ki({mu})/Ki({delta}) = 1280) has been synthesized and evaluated as a potential lung tumour imaging agent. [{sup 125}I]ITIPP({psi}) was obtained, via electrophilic iodination, in 46% yield (>44,000 MBq/{mu}mol) from the parent TIPP({psi}). The biodistribution of [{sup 125}I]ITIPP({psi}) in nu/nu mice bearing SCLC-SW210.5 xenographs revealed good uptake and prolonged retention of radioactivity in organs known to possess {delta}-opioid receptors. Metabolite analysis showed that [{sup 125}I]ITIPP({psi}) was largely unmetabolized at 25 min PI and blocking studies showed significant reduction of uptake of the tracer in the brain, liver, intestine and tumor indicating that the iodinated tetrapeptide binds to {delta} opioid receptors in vivo.

  13. Correcting ligands, metabolites, and pathways

    Directory of Open Access Journals (Sweden)

    Vriend Gert

    2006-11-01

    Full Text Available Abstract Background A wide range of research areas in bioinformatics, molecular biology and medicinal chemistry require precise chemical structure information about molecules and reactions, e.g. drug design, ligand docking, metabolic network reconstruction, and systems biology. Most available databases, however, treat chemical structures more as illustrations than as a datafield in its own right. Lack of chemical accuracy impedes progress in the areas mentioned above. We present a database of metabolites called BioMeta that augments the existing pathway databases by explicitly assessing the validity, correctness, and completeness of chemical structure and reaction information. Description The main bulk of the data in BioMeta were obtained from the KEGG Ligand database. We developed a tool for chemical structure validation which assesses the chemical validity and stereochemical completeness of a molecule description. The validation tool was used to examine the compounds in BioMeta, showing that a relatively small number of compounds had an incorrect constitution (connectivity only, not considering stereochemistry and that a considerable number (about one third had incomplete or even incorrect stereochemistry. We made a large effort to correct the errors and to complete the structural descriptions. A total of 1468 structures were corrected and/or completed. We also established the reaction balance of the reactions in BioMeta and corrected 55% of the unbalanced (stoichiometrically incorrect reactions in an automatic procedure. The BioMeta database was implemented in PostgreSQL and provided with a web-based interface. Conclusion We demonstrate that the validation of metabolite structures and reactions is a feasible and worthwhile undertaking, and that the validation results can be used to trigger corrections and improvements to BioMeta, our metabolite database. BioMeta provides some tools for rational drug design, reaction searches, and

  14. Synthetic cannabinoids: analysis and metabolites.

    Science.gov (United States)

    Elsohly, Mahmoud A; Gul, Waseem; Wanas, Amira S; Radwan, Mohamed M

    2014-02-27

    Cannabimimetics (commonly referred to as synthetic cannabinoids), a group of compounds encompassing a wide range of chemical structures, have been developed by scientists with the hope of achieving selectivity toward one or the other of the cannabinoid receptors CB1 and CB2. The goal was to have compounds that could possess high therapeutic activity without many side effects. However, underground laboratories have used the information generated by the scientific community to develop these compounds for illicit use as marijuana substitutes. This chapter reviews the different classes of these "synthetic cannabinoids" with particular emphasis on the methods used for their identification in the herbal products with which they are mixed and identification of their metabolites in biological specimens.

  15. The Okavango: Whose Delta is it?

    Science.gov (United States)

    Magole, Lapologang; Magole, Lefatshe Innocent

    The Okavango Delta is amongst the largest Ramsar sites ( http://www.ramsar.org/sitelist.pdf) in the world and an important wetland for community livelihoods, conservation and tourism in Botswana. Over the years, the utilization of the delta has shifted from communal use to state control, with an increased use for conservation and tourism. This increased use for conservation and tourism has manifested in the physical expansion of the conservation area - Moremi Game Reserve and the formation of Wildlife Management Areas (WMAs) around the reserve, whose primary land use is wildlife utilization. The expansion of the conservation area has translated into several practical matters, including expansion of the area for non-hunting activities or photographic areas. The livelihoods of local communities of the Okavango delta who depended on fishing, hunter-gathering, livestock rearing, rain-fed agriculture and flood recession farming have been negatively affected by the expansion of conservation and tourism in the delta. The livelihoods alternatives in the form of Community Based Natural Resource Management (CBNRM) and tourism have not provided substitutes for the people as the communities are still reliant on the same old livelihood sources as in the past, albeit within smaller and restricted areas. This paper explores the ownership of the natural resources within the Okavango Delta. It asks and attempts to answer the following questions: Who owns and controls the use of the land? Who has access to other resources there in? Who makes the decisions on how the delta resources should be managed and used? Who benefits from the delta resources? We argue firstly that ownership of the delta as defined by legal parameters and demonstrated in natural resource management practice is vested on government. Secondly, government, after assuming ownership of the delta continues to sell its stake to the international community, at the expense of local ownership and access to resources. We

  16. Microsomal metabolism of trenbolone acetate metabolites ...

    Science.gov (United States)

    Trenbolone acetate (TBA) is a synthetic growth promoter widely used in animal agriculture, and its metabolites are suspected endocrine disrupting compounds in agriculturally impacted receiving waters. However, beyond the three widely recognized TBA metabolites (17-trenbolone, 17-trenbolone and trendione), little is known about other metabolites formed in vivo and subsequently discharged into the environment, with some evidence suggesting these unknown metabolites comprise a majority of the TBA mass dosed to the animal. Here, we explored the metabolism of the three known TBA metabolites using rat liver microsome studies. All TBA metabolites are transformed into a complex mixture of monohydroxylated products. Based on product characterization, the majority are more polar than the parent metabolites but maintain their characteristic trienone backbone. A minor degree of interconversion between known metabolites was also observed, as were higher order hydroxylated products with a greater extent of reaction. Notably, the distribution and yield of products were generally comparable across a series of variably induced rat liver microsomes, as well as during additional studies with human and bovine liver microsomes. Bioassays conducted with mixtures of these transformation products suggest that androgen receptor (AR) binding activity is diminished as a result of the microsomal treatment, suggesting that the transformation products are generally less potent than

  17. [Biologically active metabolites of the marine actinobacteria].

    Science.gov (United States)

    Sobolevskaia, M P; Kuznetsova, T A

    2010-01-01

    This review systematically data on the chemical structure and biological activity of metabolites of obligate and facultative marine actinobacteria, published from 2000 to 2007. We discuss some structural features of the five groups of metabolites related to macrolides and compounds containing lactone, quinone and diketopiperazine residues, cyclic peptides, alkaloids, and compounds of mixed biosynthesis. Survey shows a large chemical diversity of metabolites actinobacteria isolated from marine environment. It is shown that, along with metabolites, identical to previously isolated from terrestrial actinobacteria, marine actinobacteria synthesize unknown compounds not found in other natural sources, including micro organisms. Perhaps the biosynthesis of new chemotypes bioactive compounds in marine actinobacteria is one manifestation of chemical adaptation of microorganisms to environmental conditions at sea. Review stresses the importance of the chemical study of metabolites of marine actinobacteria. These studies are aimed at obtaining new data on marine microorganisms producers of biologically active compounds and chemical structure and biological activity of new low-molecular bioregulators of natural origin.

  18. Impact of sea-level rise in a Mediteranean delta: The Ebro delta cast

    NARCIS (Netherlands)

    Sánchez-Arcilla, A.; Stive, M.D.F.; Jiménez, J.A.; García, M.A.

    1993-01-01

    In anticipation of a comprehensive, multidisciplinary study on the impact of climatic change on the Ebro Delta preliminary results are here presented of the response of the outer delta coast to present and future relative sea-level rise. Due to the absence of observations and predictions of regional

  19. Final State Interactions and Delta S=-1, Delta C=\\pm 1 B--decays

    CERN Document Server

    Fayyazuddin, A

    2002-01-01

    The final state interactions (FSI) in Delta S=-1, Delta C=\\pm 1, decays of B-meson are discussed. The rescattering corrections are found to be of order of 15-20%. The strong interaction phase shifts are estimated and their effects on CP-asymmetry are discussed.

  20. A model for the Delta(1600) resonance and gamma N -> Delta(1600) transition

    CERN Document Server

    Ramalho, G

    2010-01-01

    A covariant spectator constituent quark model is applied to study the gamma N -> Delta(1600) transition. Two processes are important in the transition: a photon couples to the individual quarks of the Delta(1600) core (quark core), and a photon couples to the intermediate pion-baryon states (pion cloud). While the quark core contributions are estimated assuming Delta(1600) as the first radial excitation of Delta(1232), the pion cloud contributions are estimated based on an analogy with the gamma N -> Delta(1232) transition. To estimate the pion cloud contributions in the gamma N -> Delta(1600) transition, we include the relevant intermediate states, pi-N, pi-Delta, pi-N(1440) and pi-Delta(1600). Dependence on the four-momentum transfer squared, Q2, is predicted for the magnetic dipole transition form factor, GM*(Q2), as well as the helicity amplitudes, A_1/2(Q2) and A_3/2(Q2). The results at Q2=0 are compared with the existing data.

  1. A model for the Delta(1600) resonance and gamma N -> Delta(1600) transition

    Energy Technology Data Exchange (ETDEWEB)

    G. Ramalho, K. Tsushima

    2010-10-01

    A covariant spectator constituent quark model is applied to study the gamma N -> Delta(1600) transition. Two processes are important in the transition: a photon couples to the individual quarks of the Delta(1600) core (quark core), and a photon couples to the intermediate pion-baryon states (pion cloud). While the quark core contributions are estimated assuming Delta(1600) as the first radial excitation of Delta(1232), the pion cloud contributions are estimated based on an analogy with the gamma N -> Delta(1232) transition. To estimate the pion cloud contributions in the gamma N -> Delta(1600) transition, we include the relevant intermediate states, pi-N, pi-Delta, pi-N(1440) and pi-Delta(1600). Dependence on the four-momentum transfer squared, Q2, is predicted for the magnetic dipole transition form factor, GM*(Q2), as well as the helicity amplitudes, A_1/2(Q2) and A_3/2(Q2). The results at Q2=0 are compared with the existing data.

  2. Impact of sea-level rise in a Mediteranean delta: The Ebro delta cast

    NARCIS (Netherlands)

    Sánchez-Arcilla, A.; Stive, M.D.F.; Jiménez, J.A.; García, M.A.

    1993-01-01

    In anticipation of a comprehensive, multidisciplinary study on the impact of climatic change on the Ebro Delta preliminary results are here presented of the response of the outer delta coast to present and future relative sea-level rise. Due to the absence of observations and predictions of regional

  3. The Enabling Delta Life Initiative - Global Programme of Action on Deltas - Programme description

    NARCIS (Netherlands)

    Driel, van W.F.; Skyllerstedt, S.; Wosten, J.H.M.

    2014-01-01

    Being ‘hotspots’ of human activity with generally high population densities, deltas are vulnerable to changes induced by a range of driving forces, both natural and anthropogenic. In addition to already existing challenges, uncertainty of the possible impacts of climate change, low lying deltas arou

  4. Houtman Abrolhos Isotope (delta 18O, delta 13C) Data for 1795 to 1994

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — DESCRIPTION: VARIABLES AND UNITS: Column #1: core depth in mm Column #2: delta C-13 vs V-PDB Column #3: delta O-18 vs V-PDB Column #4: assigned date in years A.D....

  5. \\Delta Y/ \\Delta Z from the analysis of local K dwarfs

    CERN Document Server

    Gennaro, Mario; Degl'Innocenti, Scilla

    2010-01-01

    The stellar helium-to-metal enrichment ratio, \\Delta Y/\\Delta Z, is a widely studied astrophysical quantity. However, its value is still not precisely constrained. This paper is focused on the study of the main sources of uncertainty which affect the \\Delta Y/\\Delta Z derived from the analysis of the low-main sequence (MS) stars in the solar neighborhood. The possibility to infer the value of \\Delta Y/\\Delta Z from the study of low-MS stars relies on the dependence of the stellar luminosity and effective temperature on the initial Y and Z. The \\Delta Y/\\Delta Z ratio is obtained by comparing the magnitude difference between the observed stars and a reference theoretical zero age main sequence (ZAMS) with the related theoretical magnitude differences computed from a new set of stellar models with up-to-date input physics and a fine grid of chemical compositions. A Monte Carlo approach has been used to evaluate the impact on the result of different sources of uncertainty, i.e. observational errors, evolutionary...

  6. Holocene delta plain development in the Song Hong (Red River) delta, Vietnam

    Science.gov (United States)

    Funabiki, Ayako; Haruyama, Shigeko; Quy, Nguyen Van; Hai, Pham Van; Thai, Dinh Hung

    2007-05-01

    Holocene delta plain development was investigated based on three sediment cores analyzed in detail from the Song Hong (Red River) delta plain in Vietnam. Two cores (DA and PD) from the western delta plain showed both the landward limit of the transgressive estuarine system in the valley incised during the last glacial maximum and floodplain evolution since the middle Holocene. On the other hand, a core (TL) from the eastern delta plain revealed a Pleistocene terrace buried under the deltaic sediments and a slow accumulation rate compared with that in the west. At 8 cal ky BP, the shoreline migrated very close to the present Hanoi city area, and the sedimentary environment changed to tidal flat or salt marsh. Hanoi city marks the northern limit of shoreline transgression. The mangrove swamp expanded from 8 to 5 cal ky BP to the landward limit of the delta plain. Subsequently, the shoreline migrated seaward as a result of delta progradation and sea-level lowering. From 5 cal ky BP, the emerged area evolved into a floodplain and natural levees formed along the abandoned river channels on the western delta plain, but at 2 cal ky, archeological sites indicate that the Holocene terrace in the eastern delta plain was still inundated.

  7. Delta(9)-tetrahydrocannabinol, 11-hydroxy-delta(9)-tetrahydrocannabinol and 11-nor-9-carboxy-delta(9)-tetrahydrocannabinol in human plasma after controlled oral administration of cannabinoids.

    Science.gov (United States)

    Goodwin, Robert S; Gustafson, Richard A; Barnes, Allan; Nebro, Wesenyalsh; Moolchan, Eric T; Huestis, Marilyn A

    2006-08-01

    A clinical study to investigate the pharmacokinetics and pharmacodynamics of oral tetrahydrocannabinol was performed. This randomized, double-blind, placebo-controlled, within-subject, inpatient study compared the effects of THC-containing hemp oils in liquid and capsule form to dronabinol (synthetic THC) in doses used for appetite stimulation. The National Institute on Drug Abuse Institutional Review Board approved the protocol and each participant provided informed consent. Detection times and concentrations of THC, 11-hydroxy-Delta-tetrahydrocannabinol (11-OH-THC), and 11-nor-9-carboxy-Delta-tetrahydrocannabinol (THCCOOH) in plasma were determined by gas chromatography-mass spectrometry [limits of quantification (LOQ)=0.5, 0.5, and 1.0 ng/mL, respectively] after oral THC administration. Six volunteers ingested liquid hemp oil (0.39 and 14.8 mg THC/d), hemp oil in capsules (0.47 mg THC/d), dronabinol capsules (7.5 mg THC/d), and placebo. Plasma specimens were collected during and after each dosing condition. THC and 11-OH-THC concentrations were low and never exceeded 6.1 ng/mL. Analytes were detectable 1.5 hour after initiating dosing with the 7.5 mg THC/d regimen and 4.5 hour after starting the 14.8 mg THC/d sessions. THCCOOH was detected 1.5 hour after the first dose, except for the 0.47 mg THC/d session, which required 4.5 hour for concentrations to reach the LOQ. THCCOOH concentrations peaked at 3.1 ng/mL during dosing with the low-dose hemp oils. Plasma THC and 11-OH-THC concentrations were negative for all participants at all doses within 15.5 hours after the last THC dose. Plasma THCCOOH persisted for at least 39.5 hours after the end of dosing and at much higher concentrations (up to 43.0 ng/mL). This study demonstrated that subjects who used high THC content hemp oil (347 mug/mL) as a dietary supplement had THC and metabolites in plasma in quantities comparable to those of patients using dronabinol for appetite stimulation. There was a significant

  8. MODIFICATION OF DELTA FOR CHOOSER OPTIONS

    Directory of Open Access Journals (Sweden)

    Marek Ďurica

    2015-09-01

    Full Text Available Correctly used financial derivatives can help investors increase their expected returns and minimize their exposure to risk. To ensure the specific needs of investors, a large number of different types of non-standard exotic options is used. Chooser option is one of them. It is an option that gives its holder the right to choose at some predetermined future time whether the option will be a standard call or put with predetermined strike price and maturity time. Although the chooser options are more expensive than standard European-style options, in many cases they are a more suitable instrument for investors in hedging their portfolio value. For an effective use of the chooser option as a hedging instrument, it is necessary to check the values of the Greek parameters delta and gamma for the options. Especially, if the value of the parameter gamma is too large, hedging of the portfolio value using only parameter delta is insufficient and brings high transaction costs because the portfolio has to be reviewed relatively often. Therefore, in this article, a modification of delta-hedging as well as using the value of parameter gamma is suggested. Error of the delta modification is analyzed and compared with the error of widely used parameter delta. Typical patterns for the modified hedging parameter variation with various time to choose time for chooser options are also presented in this article.

  9. Notched delta, phenotype, and Angelman syndrome.

    Science.gov (United States)

    Korff, Christian M; Kelley, Kent R; Nordli, Douglas R

    2005-08-01

    The notched delta pattern is one of the characteristic EEG features found in Angelman syndrome patients. The purpose of this study was to evaluate the possibility of using the notched delta pattern as a detection tool for Angelman syndrome patients by analyzing its frequency in a tertiary care pediatric center, its specificity for Angelman syndrome, and the age at which it was observed. The authors performed a retrospective review of the video-EEG recordings of all the patients who had either the notched delta pattern or a phenotype consistent with Angelman syndrome. The notched delta was observed in 1.1% of all the EEGs performed. Its specificity for Angelman syndrome was evaluated at 38%. The youngest age at which it was noted was 14 months. The results indicate that the notched delta pattern is relatively rare, but more frequent than expected, and is easily recognizable. The pattern was observed not only in Angelman syndrome patients, but also in children with a spectrum of conditions wider than reported. It is a powerful detection tool for Angelman syndrome when correlated to a suggestive phenotype, and the association of these features should raise suspicion for Angelman syndrome in both infants and adults.

  10. Tracking Nile Delta vulnerability to Holocene change.

    Directory of Open Access Journals (Sweden)

    Nick Marriner

    Full Text Available Understanding deltaic resilience in the face of Holocene climate change and human impacts is an important challenge for the earth sciences in characterizing the full range of present and future wetland responses to global warming. Here, we report an 8000-year mass balance record from the Nile Delta to reconstruct when and how this sedimentary basin has responded to past hydrological shifts. In a global Holocene context, the long-term decrease in Nile Delta accretion rates is consistent with insolation-driven changes in the 'monsoon pacemaker', attested throughout the mid-latitude tropics. Following the early to mid-Holocene growth of the Nile's deltaic plain, sediment losses and pronounced erosion are first recorded after ~4000 years ago, the corollaries of falling sediment supply and an intensification of anthropogenic impacts from the Pharaonic period onwards. Against the backcloth of the Saharan 'depeopling', reduced river flow underpinned by a weakening of monsoonal precipitation appears to have been particularly conducive to the expansion of human activities on the delta by exposing productive floodplain lands for occupation and irrigation agriculture. The reconstruction suggests that the Nile Delta has a particularly long history of vulnerability to extreme events (e.g. floods and storms and sea-level rise, although the present sediment-starved system does not have a direct Holocene analogue. This study highlights the importance of the world's deltas as sensitive archives to investigate Holocene geosystem responses to climate change, risks and hazards, and societal interaction.

  11. QCD in the {delta}-regime

    Energy Technology Data Exchange (ETDEWEB)

    Bietenholz, W. [Universidad Nacional Autonoma de Mexico, Mexico City (Mexico). Inst. de Ciencias Nucleares; Cundy, N. [Seoul National Univ. (Korea, Republic of). Lattice Gauge Theory Research Center; Goeckeler, M. [Regensburg Univ. (Germany). Inst. fuer Theoretische Physik; Horsley, R.; Zanotti, J.M. [Edinburgh Univ. (United Kingdom). School of Physics; Nakamura, Y. [Tsukuba Univ., Ibaraki (Japan). Center for Computational Sciences; Pleiter, D. [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany); Rakow, P.E.L. [Liverpool Univ. (United Kingdom). Theoretical Physics Div.; Schierholz, G. [Regensburg Univ. (Germany). Inst. fuer Theoretische Physik; Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany)

    2011-03-15

    The {delta}-regime of QCD is characterised by light quarks in a small spatial box, but a large extent in (Euclidean) time. In this setting a specific variant of chiral perturbation theory - the {delta}-expansion - applies, based on a quantum mechanical treatment of the quasi onedimensional system. In particular, for vanishing quark masses one obtains a residual pion mass M{sup R}{sub {pi}}, which has been computed to the third order in the {delta}-expansion. A comparison with numerical measurements of this residual mass allows for a new determination of some Low Energy Constants, which appear in the chiral Lagrangian. We first review the attempts to simulate 2-flavour QCD directly in the {delta}-regime. This is very tedious, but results compatible with the predictions for M{sup R}{sub {pi}} have been obtained. Then we show that an extrapolation of pion masses measured in a larger volume towards the {delta}-regime leads to good agreement with the theoretical predictions. From those results, we also extract a value for the (controversial) sub-leading Low Energy Constant anti l{sub 3}. (orig.)

  12. Interactions among mu- and delta-opioid receptors, especially putative delta1- and delta2-opioid receptors, promote dopamine release in the nucleus accumbens.

    NARCIS (Netherlands)

    Hirose, N.; Murakawa, K.; Takada, K.; Oi, Y.; Suzuki, T.; Nagase, H.; Cools, A.R.; Koshikawa, N.

    2005-01-01

    The effect of interactions among mu- and delta-opioid receptors, especially the putative delta(1)- and delta(2)-opioid receptors, in the nucleus accumbens on accumbal dopamine release was investigated in awake rats by in vivo brain microdialysis. In agreement with previous studies, perfusion of the

  13. Hydraulic engineering in the social-ecological delta: understanding the interplay between social, ecological, and technological systems in the Dutch delta by means of “delta trajectories”

    NARCIS (Netherlands)

    Staveren, van M.F.; Tatenhove, van J.P.M.

    2016-01-01

    Several of the world's largest deltas have recently been conceptualized as social-ecological delta systems. Although such conceptualizations are valuable in emphasizing complex interaction between social actors and ecological processes in deltas, they do not go into specific dynamics that surround t

  14. Interactions among mu- and delta-opioid receptors, especially putative delta1- and delta2-opioid receptors, promote dopamine release in the nucleus accumbens.

    NARCIS (Netherlands)

    Hirose, N.; Murakawa, K.; Takada, K.; Oi, Y.; Suzuki, T.; Nagase, H.; Cools, A.R.; Koshikawa, N.

    2005-01-01

    The effect of interactions among mu- and delta-opioid receptors, especially the putative delta(1)- and delta(2)-opioid receptors, in the nucleus accumbens on accumbal dopamine release was investigated in awake rats by in vivo brain microdialysis. In agreement with previous studies, perfusion of the

  15. El plan del delta - Holanda

    Directory of Open Access Journals (Sweden)

    Editorial, Equipo

    1963-09-01

    Full Text Available Holland is very poor in land resources. Hence its development has been directed towards intensive industrialization and maximum agricultural exploitation. The western part of the country is below sea level and is occupied by 65 percent of the population. Originally the coast consisted of a number of islands, estuaries and slight elevations. Man has transformed this coastline, first making a number of artificial lakes, or polders, and then converting these into fertile districts. These projects protect the soil by means of dykes, which require careful conservation, but even so violent floods are not infrequent. One of the difficult problems involved in this vast enterprise is the complex system of water supply, lines of communication and flow of the rivers into the sea along the estuary zone. This zone is on the south west, and to protect it a National Commission has been set up. After careful study, it was decided that the best defense against the violence of the sea would consist in closing off the inroads of the sea into the continental coastline. The set of hydraulic projects which constitutes this plan for the improvement of the sea defences will take 25 years to fulfil. The general project is highly ambitious and includes both maritime, road and structural works, in which there is a variety of stonework constructions. This paper describes, in brief outline, the main contents of the 11 headings into which the general construction project has been subdivided. In addition, this is supplemented with information on the projects which are already initiated and on the constructional procedure that is being adopted. Of these latter projects, the Nabla bridge is of particular interest. It is situated on the delta. It is made in prestressed concrete, and consists of 17 spans, of 60 length each. This enormous structure, in addition to its great length, and supporting a 22.8 ms wide roadway, is subjected to the tremendous forces 11» of the sea on one

  16. NATO-3C/Delta launch

    Science.gov (United States)

    1978-01-01

    NATO-3C, the third in a series of NATO defense-related communication satellites, is scheduled to be launched on a delta vehicle from the Eastern Test Range no earlier than November 15, 1978. NATO-3A and -3B were successfully launched by Delta vehicles in April 1976 and January 1977, respectively. The NATO-3C spacecraft will be capable of transmitting voice, data, facsimile, and telex messages among military ground stations. The launch vehicle for the NATO-3C mission will be the Delta 2914 configuration. The launch vehicle is to place the spacecraft in a synchronous transfer orbit. The spacecraft Apogee Kick motor is to be fired at fifth transfer orbit apogee to circularize its orbit at geosynchronous altitude of 35,900 km(22,260 miles) above the equator over the Atlantic Ocean somewhere between 45 and 50 degrees W longitude.

  17. Fluxomics with ratiometric metabolite dyes.

    Science.gov (United States)

    Chaudhuri, Bhavna; Niittylä, Totte; Hörmann, Friederike; Frommer, Wolf B

    2007-03-01

    Today's major excitement in biology centers on signaling: How can a cell or organism measure the myriad of environmental cues, integrate it, and acclimate to the new conditions? Hormonal signals and second messengers are in the focus of most of these studies, e.g., regulation of glucose transporter GLUT4 cycling by insulin, or regulation of plant growth by auxin or brassinosteroids.1-3 In comparison, we generally assume that we know almost everything about basic metabolism since it has been studied for many decades; for example we know since the early 80s that allosteric regulation by fructose-2,6-bisphophate plays an important role in regulating glycolysis in plants and animals.4 This may be the reason why studies of metabolism appear to be a bit out of fashion. But if we look to other organisms such as E. coli or yeast, we rapidly realize that metabolism is controlled by complex interconnected signaling networks, and that we understand little of these signaling networks in humans and plants.5,6 As it turns out, the cell registers many metabolites, and flux through the pathways is regulated using complex signaling networks that involve calcium as well as hormones.

  18. Secondary Metabolites from Rubiaceae Species

    Directory of Open Access Journals (Sweden)

    Daiane Martins

    2015-07-01

    Full Text Available This study describes some characteristics of the Rubiaceae family pertaining to the occurrence and distribution of secondary metabolites in the main genera of this family. It reports the review of phytochemical studies addressing all species of Rubiaceae, published between 1990 and 2014. Iridoids, anthraquinones, triterpenes, indole alkaloids as well as other varying alkaloid subclasses, have shown to be the most common. These compounds have been mostly isolated from the genera Uncaria, Psychotria, Hedyotis, Ophiorrhiza and Morinda. The occurrence and distribution of iridoids, alkaloids and anthraquinones point out their chemotaxonomic correlation among tribes and subfamilies. From an evolutionary point of view, Rubioideae is the most ancient subfamily, followed by Ixoroideae and finally Cinchonoideae. The chemical biosynthetic pathway, which is not so specific in Rubioideae, can explain this and large amounts of both iridoids and indole alkaloids are produced. In Ixoroideae, the most active biosysthetic pathway is the one that produces iridoids; while in Cinchonoideae, it produces indole alkaloids together with other alkaloids. The chemical biosynthetic pathway now supports this botanical conclusion.

  19. Liquefaction potential of Nile delta, Egypt

    Science.gov (United States)

    Fergany, Elsayed; Omar, Khaled

    2017-06-01

    Understanding how sedimentary basins respond to seismic-wave energy generated by earthquake events is a significant concern for seismic-hazard estimation and risk analysis. The main goal of this study is assessing the vulnerability index, Kg, as an indicator for liquefaction potential sites in the Nile delta basin based on the microtremor measurements. Horizontal to Vertical spectral ratio analyses (HVSR) of ambient noise data, which was conducted in 2006 at 120 sites covering the Nile delta from south to north were reprocessed using Geopsy software. HVSR factors of amplification, A, and fundamental frequency, F, were calculated and Kg was estimated for each measurement. The Kg value varies widely from south toward north delta and the potential liquefaction places were estimated. The higher vulnerability indices are associated with sites located in southern part of the Nile delta and close to the branches of Nile River. The HVSR factors were correlated with geologic setting of the Nile delta and show good correlations with the sediment thickness and subsurface stratigraphic boundaries. However, we note that sites located in areas that have greatest percentage of sand also yielded relatively high Kg values with respect to sites in areas where clay is abundant. We concluded that any earthquake with ground acceleration more than 50 gal at hard rock can cause a perceived deformation of sandy sediments and liquefaction can take place in the weak zones of Kg ≥ 20. The worst potential liquefaction zones (Kg > 30) are frequently joined to the Damietta and Rosetta Nile River branches and south Delta where relatively coarser sand exists. The HVSR technique is a very sensitive tool for lithological stratigraphy variations in two dimensions and varying liquefaction susceptibility.

  20. Discovery of novel metabolites from marine actinomycetes.

    Science.gov (United States)

    Lam, Kin S

    2006-06-01

    Recent findings from culture-dependent and culture-independent methods have demonstrated that indigenous marine actinomycetes exist in the oceans and are widely distributed in different marine ecosystems. There is tremendous diversity and novelty among the marine actinomycetes present in marine environments. Progress has been made to isolate novel actinomycetes from samples collected at different marine environments and habitats. These marine actinomycetes produce different types of new secondary metabolites. Many of these metabolites possess biological activities and have the potential to be developed as therapeutic agents. Marine actinomycetes are a prolific but underexploited source for the discovery of novel secondary metabolites.

  1. Metabolism and metabolites of polychlorinated biphenyls.

    Science.gov (United States)

    Grimm, Fabian A; Hu, Dingfei; Kania-Korwel, Izabela; Lehmler, Hans-Joachim; Ludewig, Gabriele; Hornbuckle, Keri C; Duffel, Michael W; Bergman, Åke; Robertson, Larry W

    2015-03-01

    Abstract The metabolism of polychlorinated biphenyls (PCBs) is complex and has an impact on toxicity, and thereby on the assessment of PCB risks. A large number of reactive and stable metabolites are formed in the processes of biotransformation in biota in general, and in humans in particular. The aim of this document is to provide an overview of PCB metabolism, and to identify the metabolites of concern and their occurrence. Emphasis is given to mammalian metabolism of PCBs and their hydroxyl, methylsulfonyl, and sulfated metabolites, especially those that persist in human blood. Potential intracellular targets and health risks are also discussed.

  2. All optical binary delta-sigma modulator

    Science.gov (United States)

    Sayeh, Mohammad R.; Siahmakoun, Azad

    2005-09-01

    This paper describes a novel A/D converter called "Binary Delta-Sigma Modulator" (BDSM) which operates only with nonnegative signal with positive feedback and binary threshold. This important modification to the conventional delta-sigma modulator makes the high-speed (>100GHz) all-optical implementation possible. It has also the capability to modify its own sampling frequency as well as its input dynamic range. This adaptive feature helps designers to optimize the system performance under highly noisy environment and also manage the power consumption of the A/D converters.

  3. Measurement of the Muon Decay Parameter delta

    CERN Document Server

    Gaponenko, A N; Davydov, Yu I; Depommier, P; Doornbos, J; Faszer, W; Fujiwara, M C; Gagliardi, C A; Gill, D R; Green, P; Gumplinger, P; Hasinoff, M D; Henderson, R S; Hu, J; Jamieson, B; Kitching, P; Koetke, D D; Krushinsky, A A; Lachin, Yu Yu; MacDonald, J A; MacDonald, R P; Marshall, G M; Mathie, E L; Miasoedov, L V; Mischke, R E; Musser, J R; Nord, P M; Nozar, M; Olchanski, K; Olin, A; Openshaw, R; Porcelli, T A; Poutissou, J M; Poutissou, R; Quraan, M A; Rodning, N L; Selivanov, V; Sheffer, G; Shin, B; Sobratee, F; Stanislaus, T D S; Tacik, R; Torokhov, V D; Tribble, R E; Vasilev, M A; Wright, D H

    2004-01-01

    The muon decay parameter delta has been measured by the TWIST collaboration. We find delta = 0.74964 +- 0.00066(stat.) +- 0.00112(syst.), consistent with the Standard Model value of 3/4. This result implies that the product Pmuxi of the muon polarization in pion decay, Pmu, and the muon decay parameter xi falls within the 90% confidence interval 0.9960 < Pmuxi < xi < 1.0040. It also has implications for left-right-symmetric and other extensions of the Standard Model.

  4. Flood Inundation Modelling in Data Sparse Deltas

    Science.gov (United States)

    Hawker, Laurence; Bates, Paul; Neal, Jeffrey

    2017-04-01

    An estimated 7% of global population currently live in deltas, and this number is increasing over time. This has resulted in numerous human induced impacts on deltas ranging from subsidence, upstream sediment trapping and coastal erosion amongst others. These threats have already impacted on flood dynamics in deltas and could intensify in line with human activities. However, the myriad of threats creates a large number of potential scenarios that need to be evaluated. Therefore, to assess the impacts of these scenarios, a pre-requisite is a flood inundation model that is both computationally efficient and flexible in its setup so it can be applied in data-sparse settings. An intermediate scale, which compromises between the computational speed of a global model and the detail of a case specific bespoke model, was chosen to achieve this. To this end, we have developed an intermediate scale flood inundation model at a resolution of 540m of the Mekong Delta, built with freely available data, using the LISFLOOD-FP hydrodynamic model. The purpose of this is to answer the following questions: 1) How much detail is required to accurately simulate flooding in the Mekong Delta? , 2) What characteristics of deltas are most important to include in flood inundation models? Models were run using a vegetation removed SRTM DEM and a hind-casting of tidal heights as a downstream boundary. Results indicate the importance of vegetation removal in the DEM for inundation extent and the sensitivity of water level to roughness coefficients. The propagation of the tidal signal was found to be sensitive to bathymetry, both within the river channel and offshore, yet data availability for this is poor, meaning the modeller has to be careful in his or her choice of bathymetry interpolation Supplementing global river channel data with more localised data demonstrated minor improvements in results suggesting detailed channel information is not always needed to produce good results. It is

  5. DNA polymerase III accessory proteins. I. holA and holB encoding delta and delta'.

    Science.gov (United States)

    Dong, Z; Onrust, R; Skangalis, M; O'Donnell, M

    1993-06-05

    The genes encoding the delta and delta' subunits of the 10-subunit Escherichia coli replicase, DNA polymerase III holoenzyme, have been identified and sequenced. The holA gene encoding delta is located downstream of rlpB at 15.2 min and predicts a 38.7 kda protein. The holB gene encoding delta' is located at 24.3 min and predicts a 36.9-kDa protein. Hence the delta and delta' subunits are unrelated proteins encoded by separate genes. The genes have been used to express and purify delta and delta' in quantity. The predicted amino acid sequence of delta' is homologous to the sequences of the tau and gamma subunits revealing a large amount of structural redundancy within the holoenzyme.

  6. Heat Kernel Estimate for $\\Delta+\\Delta^{\\alpha/2}$ in $C^{1,1}$ open sets

    CERN Document Server

    Chen, Zhen-Qing; Song, Renming

    2010-01-01

    We consider a family of pseudo differential operators $\\{\\Delta+ a^\\alpha \\Delta^{\\alpha/2}; a\\in (0, 1]\\}$ on $\\bR^d$ for every $d\\geq 1$ that evolves continuously from $\\Delta$ to $\\Delta + \\Delta^{\\alpha/2}$, where $\\alpha \\in (0, 2)$. It gives rise to a family of L\\'evy processes $\\{X^a, a\\in (0, 1]\\}$ in $\\bR^d$, where $X^a$ is the sum of a Brownian motion and an independent symmetric $\\alpha$-stable process with weight $a$. We establish sharp two-sided estimates for the heat kernel of $\\Delta + a^{\\alpha} \\Delta^{\\alpha/2}$ with zero exterior condition in a family of open subsets, including bounded $C^{1, 1}$ (possibly disconnected) open sets. This heat kernel is also the transition density of the sum of a Brownian motion and an independent symmetric $\\alpha$-stable process with weight $a$ in such open sets. Our result is the first sharp two-sided estimates for the transition density of a Markov process with both diffusion and jump components in open sets. Moreover, our result is uniform in $a$ in the s...

  7. Abraham Reef Stable Isotope Data (delta 13C, delta 18O, delta 14C) for 1635-1957

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Site: Abraham Reef, 22ó 06'S, 153ó 00'E, Porites australiensus, Radiocarbon (delta 14C) and Stable Isotope (del 18O and del 13C) results from bi-annual samples from...

  8. The microscopic structure of $\\pi NN$, $\\pi N\\Delta$ and $\\pi\\Delta\\Delta$ vertices in a hybrid constituent quark model

    CERN Document Server

    Jung, Ju-Hyun

    2016-01-01

    We present a microscopic description of the strong $\\pi NN$, $\\pi N\\Delta$ and $\\pi\\Delta\\Delta$ vertices. Our starting point is a constituent-quark model supplemented by an additional $3q\\pi$ non-valence component. In the spirit of chiral constituent-quark models, quarks are allowed to emit and reabsorb a pion. This multichannel system is treated in a relativistically invariant way within the framework of point-form quantum mechanics. Starting with a common $SU(6)$ spin-flavor-symmetric wave function for $N$ and $\\Delta$, we calculate the strength of the $\\pi NN$, $\\pi N\\Delta$ and $\\pi\\Delta\\Delta$ couplings and the corresponding vertex form factors. Our results are in accordance with phenomenological fits of these quantities that have been obtained within purely hadronic multichannel models for baryon resonances.

  9. Secondary metabolites of slime molds (myxomycetes).

    Science.gov (United States)

    Dembitsky, Valery M; Rezanka, Tomás; Spízek, Jaroslav; Hanus, Lumír O

    2005-04-01

    The compounds reported from the slime molds (myxomycetes) species are described. Almost 100 natural compounds including their chemical structures and biological activities are described in this review article. Only metabolites with a well-defined structure are included.

  10. Secondary metabolites of cyanobacteria Nostoc sp.

    Science.gov (United States)

    Kobayashi, Akio; Kajiyama, Shin-Ichiro

    1998-03-01

    Cyanobacteria attracted much attention recently because of their secondary metabolites with potent biological activities and unusual structures. This paper reviews some recent studies on the isolation, structural, elucidation and biological activities of the bioactive compounds from cyanobacteria Nostoc species.

  11. Streptopyrrole: An antimicrobial metabolite from Streptomyces armeniacus

    DEFF Research Database (Denmark)

    Breinholt, J.; Gürtler, Hanne; Kjær, Anders

    1998-01-01

    A colourless, crystalline metabolite, C14H12ClNO4, named streptopyrrole, has been isolated from submerged fermentation cultures of Streptomyces armeniacus by extraction, followed by chromatographic purification. Its tricyclic molecular framework, seemingly without natural product precedents...

  12. Antibacterial activity of secondary metabolites isolated from ...

    African Journals Online (AJOL)

    Aghomotsegin

    2015-10-28

    Oct 28, 2015 ... The metabolites were determined and extracted for GC analysis using the method of ... Gas chromatography-mass spectrometry (GC-MS) analysis. Bioactive ..... Ostry V (2008). Alternaria mycotoxins: an overview of chemical.

  13. Detecting beer intake by unique metabolite patterns

    DEFF Research Database (Denmark)

    Gürdeniz, Gözde; Jensen, Morten Georg; Meier, Sebastian

    2016-01-01

    Evaluation of health related effects of beer intake is hampered by the lack of accurate tools for assessing intakes (biomarkers). Therefore, we identified plasma and urine metabolites associated with recent beer intake by untargeted metabolomics and established a characteristic metabolite pattern...... representing raw materials and beer production as a qualitative biomarker of beer intake. In a randomized, crossover, single-blinded meal study (MSt1) 18 participants were given one at a time four different test beverages: strong, regular and non-alcoholic beers and a soft drink. Four participants were...... assigned to have two additional beers (MSt2). In addition to plasma and urine samples, test beverages, wort and hops extract were analyzed by UPLC-QTOF. A unique metabolite pattern reflecting beer metabolome, including metabolites derived from beer raw material (i.e. N-methyl tyramine sulfate and the sum...

  14. Psychomotor performance in relation to acute oral administration of Delta9-tetrahydrocannabinol and standardized cannabis extract in healthy human subjects.

    Science.gov (United States)

    Roser, Patrik; Gallinat, Jürgen; Weinberg, Gordon; Juckel, Georg; Gorynia, Inge; Stadelmann, Andreas M

    2009-08-01

    Abnormalities in psychomotor performance are a consistent finding in schizophrenic patients as well as in chronic cannabis users. The high levels of central cannabinoid (CB(1)) receptors in the basal ganglia, the cerebral cortex and the cerebellum indicate their implication in the regulation of motor activity. Based on the close relationship between cannabis use, the endogenous cannabinoid system and motor disturbances found in schizophrenia, we expected that administration of cannabinoids may change pattern of psychomotor activity like in schizophrenic patients. This prospective, double-blind, placebo-controlled cross-over study investigated the acute effects of cannabinoids on psychomotor performance in 24 healthy right-handed volunteers (age 27.9 +/- 2.9 years, 12 male) by comparing Delta(9)-tetrahydrocannabinol (Delta(9)-THC) and standardized cannabis extract containing Delta(9)-THC and cannabidiol. Psychomotor performance was assessed by using a finger tapping test series. Cannabis extract, but not Delta(9)-THC, revealed a significant reduction of right-hand tapping frequencies that was also found in schizophrenia. As to the pure Delta(9)-THC condition, left-hand tapping frequencies were correlated with the plasma concentrations of the Delta(9)-THC metabolite 11-OH-THC. These effects are thought to be related to cannabinoid actions on CB(1) receptors in the basal ganglia, the cerebral cortex and the cerebellum. Our data further demonstrate that acute CB(1) receptor activation under the cannabis extract condition may also affect intermanual coordination (IMC) as an index of interhemispheric transfer. AIR-Scale scores as a measure of subjective perception of intoxication were dose-dependently related to IMC which was shown by an inverted U-curve. This result may be due to functional changes involving GABAergic and glutamatergic neurotransmission within the corpus callosum.

  15. Tailoring specialized metabolite production in streptomyces.

    Science.gov (United States)

    Hiltner, Jana K; Hunter, Iain S; Hoskisson, Paul A

    2015-01-01

    Streptomycetes are prolific producers of a plethora of medically useful metabolites. These compounds are made by complex secondary (specialized) metabolic pathways, which utilize primary metabolic intermediates as building blocks. In this review we discuss the evolution of specialized metabolites and how expansion of gene families in primary metabolism has lead to the evolution of diversity in these specialized metabolic pathways and how developing a better understanding of expanded primary metabolic pathways can help enhance synthetic biology approaches to industrial pathway engineering.

  16. Synthesis of the major metabolites of Tolvaptan

    Institute of Scientific and Technical Information of China (English)

    Wei Li Wan; Jian Bo Wu; Fan Lei; Xiao Long Li; Li Hai; Yong Wu

    2012-01-01

    Tolvaptan is a nonpeptide arginine vasopressin (AVP) V2-receptor antagonist and used in the treatment of heart failure,cirrhosis,syndrome of inappropriate antidiuretic hormone secretion or other high-volume capacity of hyponatremia.The metabolites of tolvaptan are mainly produced by CYP3A4,including two major compounds named DM-4103 and DM-4107.Herein,the chemical synthesis of those two metabolites is described in this article for further study.

  17. The Significance of Lichens and Their Metabolites

    Science.gov (United States)

    Huneck, S.

    Lichens, symbiontic organisms of fungi and algae, synthesize numerous metabolites, the "lichen substances," which comprise aliphatic, cycloaliphatic, aromatic, and terpenic compounds. Lichens and their metabolites have a manifold biological activity: antiviral, antibiotic, antitumor, allergenic, plant growth inhibitory, antiherbivore, and enzyme inhibitory. Usnic acid, a very active lichen substance is used in pharmaceutical preparations. Large amounts of Pseudevernia furfuracea and Evernia prunastri are processed in the perfume industry, and some lichens are sensitive reagents for the evaluation of air pollution.

  18. Secondary metabolites in bryophytes: an ecological aspect.

    Science.gov (United States)

    Xie, Chun-Feng; Lou, Hong-Xiang

    2009-03-01

    Bryophytes frequently grow in an unfavorable environment as the earliest land plants, and inevitably biosynthesize secondary metabolites against biotic or abiotic stress. They not only defend against the plant competition, microbial attack, and insect or animal predation, but also function in UV protection, drought tolerance, and freezing survival. This review covers the ecological aspect of secondary metabolites in bryophytes and is taxonomically presented according to the ecological significances.

  19. Flux balance analysis accounting for metabolite dilution.

    Science.gov (United States)

    Benyamini, Tomer; Folger, Ori; Ruppin, Eytan; Shlomi, Tomer

    2010-01-01

    Flux balance analysis is a common method for predicting steady-state flux distributions within metabolic networks, accounting for the growth demand for the synthesis of a predefined set of essential biomass precursors. Ignoring the growth demand for the synthesis of intermediate metabolites required for balancing their dilution leads flux balance analysis to false predictions in some cases. Here, we present metabolite dilution flux balance analysis, which addresses this problem, resulting in improved metabolic phenotype predictions.

  20. Pharmacokinetics of Tyrosol Metabolites in Rats

    Directory of Open Access Journals (Sweden)

    Da-Hye Lee

    2016-01-01

    Full Text Available Tyrosol is considered a potential antioxidant; however, little is known regarding the pharmacokinetics of its metabolites. To study the pharmacokinetics of tyrosol-derived metabolites after oral administration of a single dose of tyrosol, we attempted to identify tyrosol metabolites in rat plasma by using ultra-performance liquid chromatography and quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS. Two tyrosol metabolites (M1 and M2 were detected in the plasma. M1 was identified as tyrosol-4-sulfate (T4S with an [M − H]− ion at m/z 217. While M2 showed an [M − H]− ion at m/z 151.0, its metabolite was not identified. Pharmacokinetic analysis of T4S and M2 showed rapid uptake after oral administration of tyrosol within 1 h. The metabolites were rapidly distributed in most organs and tissues and eliminated within 4 h. The greatest T4S deposition by tissue weight was observed in the liver, followed by the kidney and spleen, while M2 was most concentrated in the kidney followed by the liver and spleen. These findings indicate that T4S and M2 were distributed mainly in tissues with an abundant blood supply and were rapidly excreted in urine.

  1. Pharmacokinetics of Tyrosol Metabolites in Rats.

    Science.gov (United States)

    Lee, Da-Hye; Kim, Yang-Ji; Kim, Min Jung; Ahn, Jiyun; Ha, Tae-Youl; Lee, Sang Hee; Jang, Young Jin; Jung, Chang Hwa

    2016-01-21

    Tyrosol is considered a potential antioxidant; however, little is known regarding the pharmacokinetics of its metabolites. To study the pharmacokinetics of tyrosol-derived metabolites after oral administration of a single dose of tyrosol, we attempted to identify tyrosol metabolites in rat plasma by using ultra-performance liquid chromatography and quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS). Two tyrosol metabolites (M1 and M2) were detected in the plasma. M1 was identified as tyrosol-4-sulfate (T4S) with an [M - H](-) ion at m/z 217. While M2 showed an [M - H](-) ion at m/z 151.0, its metabolite was not identified. Pharmacokinetic analysis of T4S and M2 showed rapid uptake after oral administration of tyrosol within 1 h. The metabolites were rapidly distributed in most organs and tissues and eliminated within 4 h. The greatest T4S deposition by tissue weight was observed in the liver, followed by the kidney and spleen, while M2 was most concentrated in the kidney followed by the liver and spleen. These findings indicate that T4S and M2 were distributed mainly in tissues with an abundant blood supply and were rapidly excreted in urine.

  2. Reduced complexity MASH delta-sigma modulator

    OpenAIRE

    Ye, Zhipeng; Kennedy, Michael Peter

    2007-01-01

    A reduced complexity digital multi-stage noise shaping (MASH) delta-sigma modulator for fractional-N frequency synthesizer applications is proposed. A long word is used for the first modulator in a MASH structure; the sequence length is maximized by setting the least significant bit of the input to 1; shorter words are used in subsequent stages. Experimental results confirm simulations

  3. Strong decays of nucleon and $\\Delta$ resonances

    CERN Document Server

    Bijker, R

    1996-01-01

    We study the strong couplings of the nucleon and delta resonances in a collective model. In the ensuing algebraic treatment we derive closed expressions for decay widths which are used to analyze the experimental data for strong decays into the pion and eta channels.

  4. How stable is the Mississippi Delta?

    NARCIS (Netherlands)

    Törnqvist, T.E.; Bick, S.J.; van der Borg, K.; de Jong, A.F.M.

    2006-01-01

    Large deltas are commonly believed to exhibit rapid rates of tectonic subsidence, largely due to sediment loading of the lithosphere. As a result, deltaic plains are prone to accelerated relative sea-level rise, coastal erosion, and wetland loss. Hurricane Katrina's devastation testifies to the seve

  5. Design of Low Power Sigma Delta ADC

    Directory of Open Access Journals (Sweden)

    Mohammed Arifuddin Sohel

    2012-08-01

    Full Text Available A Low power discrete time sigma delta ADC consisting of a second order sigma delta modulator and third order Cascaded Integrated Comb (CIC filter is proposed. The second order modulator is designed to work at a signal band of 20 K Hz at an oversampling ratio of 64 with a sampling frequency of 2.56 MHz. It achieves a signal to noise ratio of 85.2dB and a resolution of 14 bits. The CIC digital filter is designed to implement a decimation factor of 64, operating at a maximum sampling frequency of 2.56 MHz. A second order sigma delta modulator is implemented in 0.18 micron CMOS technology using full custom design and the third order digital CIC decimation filter is implemented in verilog HDL. The complete Sigma Delta ADC, consisting of analog block of second order modulator and digital block of decimator consumes a total power 1.96mW.

  6. Design of Low Power Sigma Delta ADC

    Directory of Open Access Journals (Sweden)

    Mohammed Arifuddin Sohel

    2012-09-01

    Full Text Available A Low power discrete time sigma delta ADC consisting of a second order sigma delta modulator and third order Cascaded Integrated Comb (CIC filter is proposed. The second order modulator is designed to work at a signal band of 20K Hz at an oversampling ratio of 64 with a sampling frequency of 2.56 MHz. It achieves a signal to noise ratio of 85.2dB and a resolution of 14 bits. The CIC digital filter is designed to implement a decimation factor of 64, operating at a maximum sampling frequency of 2.56 MHz. A second order sigma delta modulator is implemented in 0.18micron CMOS technology using full custom design and the third order digital CIC decimation filter is implemented in verilog HDL. The complete Sigma Delta ADC, consisting of analog block of second order modulator and digital block of decimator consumes a total power 1.96mW.

  7. The Niger Delta Avengers, Autonomous Ethnic Clans and Common ...

    African Journals Online (AJOL)

    Nneka Umera-Okeke

    The situation in Niger Delta region has remained an unanswered research question. When oil was discovered .... From the foregone analysis, the greed factor is sufficient to explain the crisis in Niger. Delta given the ..... homeless. The sizeable ...

  8. Habitat Management Plan for Delta and Breton National Wildlife Refuges

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The Delta and Breton NWRs Habitat Management Plan provides a long-term vision and specific guidance on managing habitats for the resources of concern at Delta and...

  9. $\\delta-\\delta^\\prime$ generalized Robin boundary conditions and quantum vacuum fluctuations

    CERN Document Server

    Munoz-Castaneda, J M

    2014-01-01

    The effects induced by the quantum vacuum fluctuations of one massless real scalar field on a configuration of two partially transparent plates are investigated. The physical properties of the infinitely thin plates are simulated by means of Dirac-$\\delta-\\delta^\\prime$ point interactions. It is shown that the distortion caused on the fluctuations by this external background gives rise to a generalization of Robin boundary conditions. The $T$-operator for potentials concentrated on points with non defined parity is computed with total generality. The quantum vacuum interaction energy between the two plates is computed using the $TGTG$ formula to find positive, negative, and zero Casimir energies. The parity properties of the $\\delta-\\delta^\\prime$ potential allow repulsive quantum vacuum force between identical plates.

  10. Delta-Bar-Delta and directed random search algorithms to study capacitor banks switching overvoltages

    Directory of Open Access Journals (Sweden)

    Sadeghkhani Iman

    2012-01-01

    Full Text Available This paper introduces an approach to analyse transient overvoltages during capacitor banks switching based on artificial neural networks (ANN. Three learning algorithms, delta-bar-delta (DBD, extended delta-bar-delta (EDBD and directed random search (DRS were used to train the ANNs. The ANN training is based on equivalent parameters of the network and therefore, a trained ANN is applicable to every studied system. The developed ANN is trained with extensive simulated results and tested for typical cases. The new algorithms are presented and demonstrated for a partial 39-bus New England test system. The simulated results show the proposed technique can accurately estimate the peak values of switching overvoltages.

  11. Delta Delta Excitation in Proton-Proton Induced pi0pi0 Production

    CERN Document Server

    Skorodko, T; Bogoslawsky, D; Calen, H; Clement, H; Doroshkevich, E; Demiroers, L; Ekstroem, C; Fransson, K; Gustafsson, L; Hoistad, B; Ivanov, G; Jacewicz, M; Jiganov, E; Johansson, T; Khakimova, O; Keleta, S; Koch, I; Kren, F; Kullander, S; Kupsc, A; Marciniewski, P; Meier, R; Morosov, B; Pauly, C; Petren, H; Petukhov, Y; Povtorejko, A; Ruber, R J M Y; Schoenning, K; Scobel, W; Shwartz, B; Stepaniak, J; Thoerngren-Engblom, P; Tikhomirov, V; Wagner, G J; Wolke, M; Yamamoto, A; Zabierowski, J; Zlomanczuk, J

    2010-01-01

    Exclusive measurements of the $pp \\to pp\\pi^0\\pi^0$ reaction have been performed at CELSIUS/WASA at energies from threshold up to $T_p$ = 1.3 GeV. Total and differential cross sections have been obtained. Here we concentrate on energies $T_p \\ge$ 1 GeV, where the $\\Delta\\Delta$ excitation becomes the leading process. No evidence is found for a significant ABC effect beyond that given by the conventional $t$-channel $\\Delta\\Delta$ excitation. This holds also for the double-pionic fusion to the quasibound $^2$He. The data are compared to model predictions, which are based on both pion and $\\rho$ exchange. Total and differential cross sections are at variance with these predictions and call for a profound modification of the $\\rho$-exchange. A phenomenological modification allowing only a small $\\rho$ exchange contribution leads to a quantitative description of the data.

  12. {Delta}{Delta} excitation in proton-proton induced {pi}{sup 0{pi}0} production

    Energy Technology Data Exchange (ETDEWEB)

    Skorodko, T.; Bashkanov, M. [Physikalisches Institut der Universitaet Tuebingen, D-72076 Tuebingen (Germany); Bogoslawsky, D. [Joint Institute for Nuclear Research, Dubna (Russian Federation); Calen, H. [The Svedberg Laboratory, Uppsala (Sweden); Clement, H., E-mail: Clement@pit.physik.uni-tuebingen.d [Physikalisches Institut der Universitaet Tuebingen, D-72076 Tuebingen (Germany); Doroshkevich, E. [Physikalisches Institut der Universitaet Tuebingen, D-72076 Tuebingen (Germany); Demiroers, L. [Hamburg University, Hamburg (Germany); Ekstroem, C.; Fransson, K. [The Svedberg Laboratory, Uppsala (Sweden); Gustafsson, L.; Hoeistad, B. [Uppsala University, Uppsala (Sweden); Ivanov, G. [Joint Institute for Nuclear Research, Dubna (Russian Federation); Jacewicz, M. [Uppsala University, Uppsala (Sweden); Jiganov, E. [Joint Institute for Nuclear Research, Dubna (Russian Federation); Johansson, T. [Uppsala University, Uppsala (Sweden); Khakimova, O. [Physikalisches Institut der Universitaet Tuebingen, D-72076 Tuebingen (Germany); Keleta, S.; Koch, I. [Uppsala University, Uppsala (Sweden); Kren, F. [Physikalisches Institut der Universitaet Tuebingen, D-72076 Tuebingen (Germany); Kullander, S. [Uppsala University, Uppsala (Sweden)

    2011-01-10

    Exclusive measurements of the pp{yields}pp{pi}{sup 0{pi}0} reaction have been performed at CELSIUS/WASA at energies from threshold up to T{sub p}=1.3 GeV. Total and differential cross sections have been obtained. Here we concentrate on energies T{sub p{>=}}1 GeV, where the {Delta}{Delta} excitation becomes the leading process. No evidence is found for a significant ABC effect beyond that given by the conventional t-channel {Delta}{Delta} excitation. This holds also for the double-pionic fusion to the quasibound {sup 2}He. The data are compared to model predictions, which are based on both {pi}- and {rho}-exchange. Total and differential cross sections are at variance with these predictions and call for a profound modification of the {rho}-exchange. A phenomenological modification allowing only a small {rho}-exchange contribution leads to a quantitative description of the data.

  13. A delta-catenin signaling pathway leading to dendritic protrusions.

    Science.gov (United States)

    Abu-Elneel, Kawther; Ochiishi, Tomoyo; Medina, Miguel; Remedi, Monica; Gastaldi, Laura; Caceres, Alfredo; Kosik, Kenneth S

    2008-11-21

    Delta-catenin is a synaptic adherens junction protein pivotally positioned to serve as a signaling sensor and integrator. Expression of delta-catenin induces filopodia-like protrusions in neurons. Here we show that the small GTPases of the Rho family act coordinately as downstream effectors of delta-catenin. A dominant negative Rac prevented delta-catenin-induced protrusions, and Cdc42 activity was dramatically increased by delta-catenin expression. A kinase dead LIMK (LIM kinase) and a mutant Cofilin also prevented delta-catenin-induced protrusions. To link the effects of delta-catenin to a physiological pathway, we noted that (S)-3,5-dihydroxyphenylglycine (DHPG) activation of metabotropic glutamate receptors induced dendritic protrusions that are very similar to those induced by delta-catenin. Furthermore, delta-catenin RNA-mediated interference can block the induction of dendritic protrusions by DHPG. Interestingly, DHPG dissociated PSD-95 and N-cadherin from the delta-catenin complex, increased the association of delta-catenin with Cortactin, and induced the phosphorylation of delta-catenin within the sites that bind to these protein partners.

  14. Morphodynamics of a cyclic prograding delta: the Red River, Vietnam

    NARCIS (Netherlands)

    Maren, D.S. van

    2004-01-01

    River deltas are inhabited by over 60% of the world population, and are, consequently, of paramount agricultural and economical importance. They constitute unique wetland envi ronments which gives river deltas ecological importance as well. Additionally, many deltas contain large accumulations of oi

  15. 78 FR 45592 - DeltaPoint Capital IV, LP;

    Science.gov (United States)

    2013-07-29

    ... ADMINISTRATION DeltaPoint Capital IV, LP; Notice Seeking Exemption Under Section 312 of the Small Business Investment Act, Conflicts of Interest Notice is hereby given that DeltaPoint Capital IV, L.P., 45 East Avenue... Business Administration (``SBA'') Rules and Regulations (13 CFR 107.730). DeltaPoint Capital IV,...

  16. Comparative assessment of the vulnerability and resilience of 10 deltas : work document

    NARCIS (Netherlands)

    Bucx, T.; Marchand, M.; Makaske, B.; Guchte, van de C.

    2010-01-01

    Background information about: Nile delta (Egypt), Incomati delta (Mozambique), Ganges-Brahmaputra-Meghna (Bangladesh), Yangtze (China), Ciliwung (Indonesia), Mekong (Vietnam), Rhine-Meuse (The Netherlands), Danube (Romania), California Bay-Delta, Mississippi River Delta (USA)

  17. Milk metabolites and their genetic variability.

    Science.gov (United States)

    Wittenburg, D; Melzer, N; Willmitzer, L; Lisec, J; Kesting, U; Reinsch, N; Repsilber, D

    2013-04-01

    The composition of milk is crucial to evaluate milk performance and quality measures. Milk components partly contribute to breeding scores, and they can be assessed to judge metabolic and energy status of the cow as well as to serve as predictive markers for diseases. In addition to the milk composition measures (e.g., fat, protein, lactose) traditionally recorded during milk performance test via infrared spectroscopy, novel techniques, such as gas chromatography-mass spectrometry, allow for a further analysis of milk into its metabolic components. Gas chromatography-mass spectrometry is suitable for measuring several hundred metabolites with high throughput, and thus it is applicable to study sources of genetic and nongenetic variation of milk metabolites in dairy cows. Heritability and mode of inheritance of metabolite measurements were studied in a linear mixed model approach including expected (pedigree) and realized (genomic) relationship between animals. The genetic variability of 190 milk metabolite intensities was analyzed from 1,295 cows held on 18 farms in Mecklenburg-Western Pomerania, Germany. Besides extensive pedigree information, genotypic data comprising 37,180 single nucleotide polymorphism markers were available. Goodness of fit and significance of genetic variance components based on likelihood ratio tests were investigated with a full model, including marker- and pedigree-based genetic effects. Broad-sense heritability varied from zero to 0.699, with a median of 0.125. Significant additive genetic variance was observed for highly heritable metabolites, but dominance variance was not significantly present. As some metabolites are particularly favorable for human nutrition, for instance, future research should address the identification of locus-specific genetic effects and investigate metabolites as the molecular basis of traditional milk performance test traits.

  18. Evidence for a parity doublet Delta(1920)P33 and Delta(1940)D33 from gammap-->ppi;{0}eta.

    Science.gov (United States)

    Horn, I; Anisovich, A V; Anton, G; Bantes, R; Bartholomy, O; Beck, R; Beloglazov, Yu; Bogendörfer, R; Castelijns, R; Crede, V; Ehmanns, A; Ernst, J; Fabry, I; Flemming, H; Fösel, A; Fuchs, M; Funke, Chr; Gothe, R; Gridnev, A; Gutz, E; Höffgen, St; Hössl, J; Junkersfeld, J; Kalinowsky, H; Klein, F; Klempt, E; Koch, H; Konrad, M; Kopf, B; Krusche, B; Langheinrich, J; Löhner, H; Lopatin, I; Lotz, J; Matthäy, H; Menze, D; Messchendorp, J; Metag, V; Nikonov, V A; Novinski, D; Ostrick, M; van Pee, H; Sarantsev, A V; Schmidt, C; Schmieden, H; Schoch, B; Suft, G; Sumachev, V; Szczepanek, T; Thoma, U; Walther, D; Weinheimer, Chr

    2008-11-14

    Evidence is reported for the existence of a parity doublet of Delta resonances with total angular momentum J=3/2 from photoproduction of the ppi;{0}eta final state. The two parity partners Delta(1920)P33 and Delta(1940)D33 make significant contributions to the reaction. Cascades of resonances into Delta(1232)eta, N(1535)pi, and Na0(980) are clearly observed.

  19. [Secondary Metabolites from Marine Microorganisms. I. Secondary Metabolites from Marine Actinomycetes].

    Science.gov (United States)

    Orlova, T I; Bulgakova, V G; Polin, A N

    2015-01-01

    Review represents data on new active metabolites isolated from marine actinomycetes published in 2007 to 2014. Marine actinomycetes are an unlimited source of novel secondary metabolites with various biological activities. Among them there are antibiotics, anticancer compounds, inhibitors of biochemical processes.

  20. 78 FR 22911 - Delta Air Lines, Inc., Reservation Sales and Customer Care Call Center, Seatac, WA; Delta Air...

    Science.gov (United States)

    2013-04-17

    ... Employment and Training Administration Delta Air Lines, Inc., Reservation Sales and Customer Care Call Center, Seatac, WA; Delta Air Lines, Inc., Reservation Sales and Customer Care Call Center, Sioux City, IA... workers and former workers of Delta Air Lines, Inc., Reservation Sales and Customer Care Call...

  1. Pharmaceutically active secondary metabolites of marine actinobacteria.

    Science.gov (United States)

    Manivasagan, Panchanathan; Venkatesan, Jayachandran; Sivakumar, Kannan; Kim, Se-Kwon

    2014-04-01

    Marine actinobacteria are one of the most efficient groups of secondary metabolite producers and are very important from an industrial point of view. Many representatives of the order Actinomycetales are prolific producers of thousands of biologically active secondary metabolites. Actinobacteria from terrestrial sources have been studied and screened since the 1950s, for many important antibiotics, anticancer, antitumor and immunosuppressive agents. However, frequent rediscovery of the same compounds from the terrestrial actinobacteria has made them less attractive for screening programs in the recent years. At the same time, actinobacteria isolated from the marine environment have currently received considerable attention due to the structural diversity and unique biological activities of their secondary metabolites. They are efficient producers of new secondary metabolites that show a range of biological activities including antibacterial, antifungal, anticancer, antitumor, cytotoxic, cytostatic, anti-inflammatory, anti-parasitic, anti-malaria, antiviral, antioxidant, anti-angiogenesis, etc. In this review, an evaluation is made on the current status of research on marine actinobacteria yielding pharmaceutically active secondary metabolites. Bioactive compounds from marine actinobacteria possess distinct chemical structures that may form the basis for synthesis of new drugs that could be used to combat resistant pathogens. With the increasing advancement in science and technology, there would be a greater demand for new bioactive compounds synthesized by actinobacteria from various marine sources in future. Copyright © 2013 Elsevier GmbH. All rights reserved.

  2. Spectral factorization using the delta operator

    DEFF Research Database (Denmark)

    Rostgaard, Morten; Poulsen, Niels Kjølstad; Ravn, Ole

    1994-01-01

    In recent years many papers have been published abouth the gamma-operator, mostly caused by the better numerical properties and the rapprochement between continuous and discrete time. A major problem within the LQG-design of a delta-based input-output relation has been how to spectral-factorize i......In recent years many papers have been published abouth the gamma-operator, mostly caused by the better numerical properties and the rapprochement between continuous and discrete time. A major problem within the LQG-design of a delta-based input-output relation has been how to spectral......-factorize in an efficient way. The discrete-time method of Kuccera will not be applied since numerical word-length characteristics will be poor for fast sampling rates. In this paper a new approach is considered. A new gamma-operator (Tustin operator) is introduced, in order to make an iterative and numerical stable...

  3. Nucleon and Delta structure in continuum QCD

    Science.gov (United States)

    Cloet, Ian

    2014-03-01

    Quantum Chromodynamics (QCD) is the only known example in nature of a fundamental quantum field theory that is innately non-perturbative. Solving QCD will have profound implications for our understanding of the natural world, for example, it will explain how light quarks and massless gluons bind together to form the observed mesons and baryons; hence explaining the origin of more than 98% of the mass in the visible universe. Given the challenges posed by QCD, it is insufficient to study hadron ground-states alone if one seeks a solution; in this regard the delta plays a special role as the lightest baryon resonance. I will discuss recent progress using continuum QCD approaches to the study of nucleon and delta properties, with a focus on insights gained by the calculation (and measurement) of their electromagnetic form factors.

  4. Pluviometric anomaly in the Llobregat Delta

    Directory of Open Access Journals (Sweden)

    J. Mazón

    2009-01-01

    Full Text Available The data from surface automatic weather stations show that in the area of the Llobregat delta (northeast of the Iberian Peninsula we can observe greater precipitation than in nearby inland areas (Ordal, Collserola, Garraf, than on the other side of a massif located on the coast (Garraf and than on the northern coast. This distribution of the precipitation could be explained by the formation of a nocturnal surface cold front in the Llobregat delta. In order to analyze in-depth the physical mechanisms that can influence the formation of this front (topography, sea and drainage winds, two rain episodes in the area were simulated with the MM5 mesoscale model, reproducing satisfactorily the physical mechanisms that favor the appearance of the front.

  5. On regularizations of the Dirac delta distribution

    Science.gov (United States)

    Hosseini, Bamdad; Nigam, Nilima; Stockie, John M.

    2016-01-01

    In this article we consider regularizations of the Dirac delta distribution with applications to prototypical elliptic and hyperbolic partial differential equations (PDEs). We study the convergence of a sequence of distributions SH to a singular term S as a parameter H (associated with the support size of SH) shrinks to zero. We characterize this convergence in both the weak-* topology of distributions and a weighted Sobolev norm. These notions motivate a framework for constructing regularizations of the delta distribution that includes a large class of existing methods in the literature. This framework allows different regularizations to be compared. The convergence of solutions of PDEs with these regularized source terms is then studied in various topologies such as pointwise convergence on a deleted neighborhood and weighted Sobolev norms. We also examine the lack of symmetry in tensor product regularizations and effects of dissipative error in hyperbolic problems.

  6. Matrix multiplication on the Intel Touchstone Delta

    Energy Technology Data Exchange (ETDEWEB)

    Huss-Lederman, S.; Jacobson, E.M.; Tsao, A. [Supercomputing Research Center, Bowie, MD (United States); Zhang, G. [CONVEX Computer Corp., Richardson, TX (United States)

    1993-12-31

    Matrix multiplication is a key primitive in block matrix algorithms such as those found in LAPACK. We present results from our study of matrix multiplication algorithms on the Intel Touchstone Delta, a distributed memory message-passing architecture with a two-dimensional mesh topology. We obtain an implementation that uses communication primitives highly suited to the Delta and exploits the single node assembly-coded matrix multiplication. Our algorithm is completely general, able to deal with arbitrary mesh aspect ratios and matrix dimensions, and has achieved parallel efficiency of 86% with overall peak performance in excess of 8 Gflops on 256 nodes for an 8800 {times} 8800 matrix. We describe our algorithm design and implementation, and present performance results that demonstrate scalability and robust behavior over varying mesh topologies.

  7. Clostridium perfringens Delta-Toxin Induces Rapid Cell Necrosis.

    Directory of Open Access Journals (Sweden)

    Soshi Seike

    Full Text Available Clostridium perfringens delta-toxin is a β-pore-forming toxin and a putative pathogenic agent of C. perfringens types B and C. However, the mechanism of cytotoxicity of delta-toxin remains unclear. Here, we investigated the mechanisms of cell death induced by delta-toxin in five cell lines (A549, A431, MDCK, Vero, and Caco-2. All cell lines were susceptible to delta-toxin. The toxin caused rapid ATP depletion and swelling of the cells. Delta-toxin bound and formed oligomers predominantly in plasma membrane lipid rafts. Destruction of the lipid rafts with methyl β-cyclodextrin inhibited delta-toxin-induced cytotoxicity and ATP depletion. Delta-toxin caused the release of carboxyfluorescein from sphingomyelin-cholesterol liposomes and formed oligomers; toxin binding to the liposomes declined with decreasing cholesterol content in the liposomes. Flow cytometric assays with annexin V and propidium iodide revealed that delta-toxin treatment induced an elevation in the population of annexin V-negative and propidium iodide-positive cells. Delta-toxin did not cause the fragmentation of DNA or caspase-3 activation. Furthermore, delta-toxin caused damage to mitochondrial membrane permeability and cytochrome c release. In the present study, we demonstrate that delta-toxin produces cytotoxic activity through necrosis.

  8. Elastic and transition form factors of the \\Delta(1232)

    CERN Document Server

    Segovia, Jorge; Cloët, Ian C; Roberts, Craig D; Schmidt, Sebastian M; Wan, Shaolong

    2013-01-01

    Predictions obtained with a confining, symmetry-preserving treatment of a vector-vector contact interaction at leading-order in a widely used truncation of QCD's Dyson-Schwinger equations are presented for \\Delta and \\Omega baryon elastic form factors and the \\gamma N -> \\Delta transition form factors. This simple framework produces results that are practically indistinguishable from the best otherwise available, an outcome which highlights that the key to describing many features of baryons and unifying them with the properties of mesons is a veracious expression of dynamical chiral symmetry breaking in the hadron bound-state problem. The following specific results are of particular interest. The \\Delta elastic form factors are very sensitive to m_\\Delta. Hence, given that the parameters which define extant simulations of lattice-regularised QCD produce \\Delta-resonance masses that are very large, the form factors obtained therewith are a poor guide to properties of the \\Delta(1232). Considering the \\Delta-b...

  9. [Quantitative relationship between molecular structure of polychlorinated biphenyls (PCBs) and enthalpy change (deltaH), entropy change (deltaS') in chromatographic process].

    Science.gov (United States)

    Zhang, Qing; Dai, Chaozheng

    2005-09-01

    The relationship between the rule of chromatographic retention value and molecular structure is an important part in the research of chromatographic thermodynamics. The topological index structural parameter JG and the topological index adjoining parameter LJ are put forward. Parameter J(G) describes the correlation of quantity and position of chlorine atoms in polychlorinated biphenyl (PCB) molecules. Parameter L(J) describes the ortho-position correlation of chlorine atoms in PCB molecules. The relational expression between the PCB molecular structures and their enthalpy change (deltaH), entropy change (deltaS') in chromatographic process was discovered. The values of enthalpy change and entropy change for about 140 kinds of polychlorinated biphenyls in chromatographic process on three stationary phases, DB-1, DB-5 and DB-1701, were determined. In comparison with deltaH and deltaS' of the experimental data those calculated from the relational expression had the average relative deviations for deltaH and deltaS' are 0.56% -0.97% and 0.55% - 1.06%, respectively.

  10. Performance evaluation of photonic Sigma Delta ADCS

    OpenAIRE

    Tan, Yean Wee

    2010-01-01

    Approved for public release; distribution is unlimited The integration of photonic and electronic components to realize a photonic sigma delta ADC is considered in this thesis. The integration process was broken up into steps. First, the performance of a pair of dual-port Mach-Zehnder interferometers (MZI) modulating a train of narrow high-speed laser pulses from a mode-locked laser was investigated. Various parameters like the half-wave voltage (V) and insertion loss were verified. Nex...

  11. Delta Greenbriar - Atlanta – (EE. UU.

    Directory of Open Access Journals (Sweden)

    Heery, George

    1975-05-01

    Full Text Available «Delta Greenbriar» is a corporate centre for the Delta air line company. The complex comprises four buildings containing: 1 the installations for flight simulation; 2 the air training base; 3 the control centre for flights and communications; 4 the department for tickets and reservations. They consist of one of two storeys. The lower ones can be extended both horizontally as well as vertically, whereas the other ones can only be enlarged in horizontal direction. The unit has been designed like a university campus, with patios, inner gardens and exterior corridors which apart from connecting the various buildings with each other also provide a close contact between the office premises and the park.El «Delta Greenbriar» es un centro corporativo para la compañía de líneas aéreas Delta. El complejo está constituido por cuatro edificios, que alojan: 1 las instalaciones para la simulación de vuelo; 2 la base de entrenamiento aéreo; 3 el centro de control de vuelo y comunicaciones; 4 el departamento de reservas y venta de billetes. Constan de una o dos plantas, pudiéndose ampliar los más bajos tanto horizontal como verticalmente, mientras que los otros sólo pueden aumentarse en sentido horizontal. El conjunto se ha diseñado como un campus universitario, con patios, ajardinamiento interior y corredores exteriores que, además de enlazar los distintos edificios entre sí, ponen en estrecha relación los espacios de oficinas con el parque.

  12. Probing Delta structure with pion electromagnetic production

    CERN Document Server

    Yang, S N; Yang, Shin Nan

    2003-01-01

    The Dubna-Mainz-Taipei dynamical model for pion electromagnetic production, which can describe well the existing data from threshold up to 1 GeV photon lab energy, is presented and used to analyze the recent precision data in the $\\Delta$ region. We find that, within our model, the bare Delta is almost spherical while the physical Delta is oblate. The deformation is almost saturated by the pion cloud effects. We further find that up to Q^2 = 4.0 (GeV/c)^2, the extracted helicity amplitude A_{3/2} and A_{1/2} remain comparable with each other, implying that hadronic helicity is not conserved at this range of Q^2. The ratio E_{1+}/M_{1+} obtained show, starting from a small and negative value at the real photon point, a clear tendency to cross zero, and to become positive with increasing Q^2. This is a possible indication of a very slow approach toward the pQCD region. Finally, we find that the bare helicity amplitude A_{1/2} and S_{1/2}, but not A_{3/2}, starts exhibiting the scaling behavior at about Q^2 \\ge ...

  13. Evolution of Modern Yellow River Delta Coast

    Institute of Scientific and Technical Information of China (English)

    尹延鸿; 周永青; 丁东

    2004-01-01

    This paper deals with the development and evolution of modem Yellow River delta and the erosion or deposition rates of its different sections. In June, 1996,Yellow Rivers terminal course was artificially turned eastwards to empty into the sea and then the 11th lobe of the modern Yellow River delta began to form. This course change may mark the beginning of the 3rd subdelta formation. As a result of that, the Yellow River delta advances towards east by north with the 1st, 2nd and 3rd subdeltas arranged in succession. Coast zone in the deltaic area is divided into 7 different sections according to their different erosion or deposition rates: the relatively stable section from Dakou River to Shunjiang Stream, the weakly retreating section from Shun jiang Stream to the Tiaohe River mouth, the strongly retreating section from the Tiaohe River mouth to the station 106, the artificially stable section due to stone dam protection from the station 106 to Gudong Oilfield, the strong deposition section from Gudong Oilfield to Dawenliu Haipu, the weakly deposition section from Dawenliu Haipu to the Zimai Stream mouth, and the stable section from the Zimai Stream mouth to the Jiaolai River mouth. It is predicted that the erosion and deposition situations of the sections will nearly remain the same in 10 years, but the retreating and silting-up rates will tend to become slower gradually. Human activities have an evident influence on the changes of the coastline.

  14. GLOBAL CHARM OF THE CHANGJIANG RIVER DELTA

    Institute of Scientific and Technical Information of China (English)

    CHEN Shu-peng; ZHOU Cheng-hu; CHEN Qiu-xiao

    2003-01-01

    Based on the theory of geo-economy, under the new situation of global economy, information network and China's entry into WTO, also with the holding of APEC (in 2001) and the International Exposition in the near future, the Changjiang (Yangtze) River Delta is striding toward the spectacular international multi-polar situation and becomes one of core regions with high-speed development. Facing the ocean and world all along, leading the progressive tides of the age and scintillating the splendor of the nation, she does advance with time. Through a long period of irrigation projects construction and intensive operation of lands in previous agricultural society, the artificial wetland ecosystem with a positive cycle had ever been formed in this region. At present, environmental pollution and urban expansion resulted from post-industrialization are being rectified. The delta will be the paradigm of industrial and agricultural modernization along the sustainable development road. With the rapid development of urbanization,she has been one of the regions with the highest density population and high urbanization level. Taking the Changjiang River estuary and the Hangzhou Bay as two parts, she is continuously strengthening and adjusting her interiorstructure, expanding mothball space and constructing the oriental modern "logistics center" to link the whole world. The butterfly-style urban system of the Changjiang River Delta is flying, probably engendering earthshaking "butterfly effect".

  15. Delta: Data Reduction for Integrated Application Workflows.

    Energy Technology Data Exchange (ETDEWEB)

    Lofstead, Gerald Fredrick [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Jean-Baptiste, Gregory [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Oldfield, Ron A. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-06-01

    Integrated Application Workflows (IAWs) run multiple simulation workflow components con- currently on an HPC resource connecting these components using compute area resources and compensating for any performance or data processing rate mismatches. These IAWs require high frequency and high volume data transfers between compute nodes and staging area nodes during the lifetime of a large parallel computation. The available network band- width between the two areas may not be enough to efficiently support the data movement. As the processing power available to compute resources increases, the requirements for this data transfer will become more difficult to satisfy and perhaps will not be satisfiable at all since network capabilities are not expanding at a comparable rate. Furthermore, energy consumption in HPC environments is expected to grow by an order of magnitude as exas- cale systems become a reality. The energy cost of moving large amounts of data frequently will contribute to this issue. It is necessary to reduce the volume of data without reducing the quality of data when it is being processed and analyzed. Delta resolves the issue by addressing the lifetime data transfer operations. Delta removes subsequent identical copies of already transmitted data during transfers and restores those copies once the data has reached the destination. Delta is able to identify duplicated information and determine the most space efficient way to represent it. Initial tests show about 50% reduction in data movement while maintaining the same data quality and transmission frequency.

  16. Modelling repeatedly flaring delta-sunspots

    CERN Document Server

    Chatterjee, Piyali; Carlsson, Mats

    2016-01-01

    Active regions (AR) appearing on the surface of the Sun are classified into $\\alpha$, $\\beta$, $\\gamma$, and $\\delta$ by the rules of the Mount Wilson Observatory, California on the basis of their topological complexity. Amongst these, the $\\delta$-sunspots are known to be super-active and produce the most X-ray flares. Here, we present results from a simulation of the Sun by mimicking the upper layers and the corona, but starting at a more primitive stage than any earlier treatment. We find that this initial state consisting of only a thin sub-photospheric magnetic sheet breaks into multiple flux-tubes which evolve into a colliding-merging system of spots of opposite polarity upon surface emergence, similar to those often seen on the Sun. The simulation goes on to produce many exotic $\\delta$-sunspot associated phenomena: repeated flaring in the range of typical solar flare energy release and ejective helical flux ropes with embedded cool-dense plasma filaments resembling solar coronal mass ejections.

  17. Understanding delta-sigma data converters

    CERN Document Server

    Pavan, Shanti; Temes, Gabor C

    2017-01-01

    This new edition introduces novel analysis and design techniques for delta-sigma (ΔΣ) converters in physical and conceptual terms, and includes new chapters that explore developments in the field over the last decade. This book explains the principles and operation of delta-sigma analog-to-digital converters (ADCs) in physical and conceptual terms in accordance with the most recent developments in the field. The interest of ΔΣ converter designers has shifted significantly over the past decade, due to many new applications for data converters at the far ends of the frequency spectrum. Continuous-time delta-sigma A/D converters with GHz clocks, of both lowpass and bandpass types, are required for wireless applications. At the other extreme, multiplexed ADCs with very narrow (sometimes 10 Hz wide) signal bandwidths, but very high accuracy are needed in the interfaces of biomedical and environmental sensors. To reflect the changing eeds of designers, the second edition includes significant new material on bo...

  18. Adaptive Delta Management: cultural aspects of dealing with uncertainty

    Science.gov (United States)

    Timmermans, Jos; Haasnoot, Marjolijn; Hermans, Leon; Kwakkel, Jan

    2016-04-01

    Deltas are generally recognized as vulnerable to climate change and therefore a salient topic in adaptation science. Deltas are also highly dynamic systems viewed from physical (erosion, sedimentation, subsidence), social (demographic), economic (trade), infrastructures (transport, energy, metropolization) and cultural (multi-ethnic) perspectives. This multi-faceted dynamic character of delta areas warrants the emergence of a branch of applied adaptation science, Adaptive Delta Management, which explicitly focuses on climate adaptation of such highly dynamic and deeply uncertain systems. The application of Adaptive Delta Management in the Dutch Delta Program and its active international dissemination by Dutch professionals results in the rapid dissemination of Adaptive Delta Management to deltas worldwide. This global dissemination raises concerns among professionals in delta management on its applicability in deltas with cultural conditions and historical developments quite different from those found in the Netherlands and the United Kingdom where the practices now labelled as Adaptive Delta Management first emerged. This research develops an approach and gives a first analysis of the interaction between the characteristics of different approaches in Adaptive Delta Management and their alignment with the cultural conditions encountered in various delta's globally. In this analysis, first different management theories underlying approaches to Adaptive Delta Management as encountered in both scientific and professional publications are identified and characterized on three dimensions: The characteristics dimensions used are: orientation on today, orientation on the future, and decision making (Timmermans, 2015). The different underlying management theories encountered are policy analysis, strategic management, transition management, and adaptive management. These four management theories underlying different approaches in Adaptive Delta Management are connected to

  19. On the determination of low-energy constants for {delta}S=1 transitions

    Energy Technology Data Exchange (ETDEWEB)

    Giusti, L.; Pena, C. [European Organization for Nuclear Research, Geneva (Switzerland); Hernandez, P. [Dpto. Fisica Teorica and IFIC, Edificio Institutos Investigacion, Valencia (Spain); Laine, M. [Bielefeld Univ. (Germany). Fakultaet fuer Physik; Wennekers, J.; Wittig, H. [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany)

    2005-10-01

    We present our preliminary results for three-point correlation functions involving the operators entering the {delta}S=1 effective Hamiltonian with an active charm quark, obtained using overlap fermions in the quenched approximation. This is the first computation carried out for valence quark masses small enough so as to permit a matching to Quenched Chiral Perturbation Theory in the {epsilon}-regime. The commonly observed large statistical fluctuations are tamed by means of low-mode averaging techniques, combined with restrictions to individual topological sectors. We also discuss the matching of the resulting hadronic matrix elements to the effective low-energy constants for {delta}S=1 transitions. This involves (a) finite-volume corrections which can be evaluated at NLO in Quenched Chiral Perturbation Theory, and (b) the short-distance renormalization of the relevant four-quark operators in discretizations based on the overlap operator. We discuss perturbative estimates for the renormalization factors and possible strategies for their non-perturbative evaluation. Our results can be used to isolate the long-distance contributions to the {delta}I=1/2 rule, coming from physics effects around the intrinsic QCD scale. (orig.)

  20. Metabolites from mangrove endophytic fungus Dothiorella sp.

    Institute of Scientific and Technical Information of China (English)

    XUQingyan; WANGJianfeng; HUANGYaojian; ZHENGZhonghui; SONGSiyang; ZHANGYongmin; SUWenjin

    2004-01-01

    Mangroves are special woody plant communities in the intertidal zone of tropical and subtropical coasts. They prove to be a natural microorganisms and new metabolites storage. In the study of mangrove endophytic fungi metabolites, four new compounds, Compounds 1, 2, 3 and 4, as well as a known octaketide, cytosporone B (5), are isolated from an endophytic fungus, Dothiorella sp., HTF3. They all show cytotoxic activities. The elucidation of these structures is mainly based on 1D/2D NMR and ESI-MS spectral analyses.

  1. Keanekaragaman metabolit sekunder Genus Artocarpus (Moraceae

    Directory of Open Access Journals (Sweden)

    ALIEFMAN HAKIM

    2011-11-01

    Full Text Available Hakim A. 2011. Keanekaragaman metabolit sekunder Genus Artocarpus (Moraceae. Bioteknologi 8: 86-98. Beberaapa spesies dari genus Artocarpus (Moraceae telah diteliti kandungan bahan alamnya. Metabolit sekunder yang berhasil diisolasi dari genus Artocarpus terdiri dari terpenoid, flavonoid, stilbenoid, arilbenzofuran, neolignan, dan adduct Diels-Alder. Kelompok flavonoid merupakan senyawa yang paling banyak ditemukan dari tumbuhan Artocarpus. Senyawa flavonoid yang telah berhasil diisolasi dari tumbuhan Artocarpus memiliki kerangka yang beragam seperti calkon, flavanon, flavan-3-ol, flavon sederhana, prenilflavon, oksepinoflavon, piranoflavon, dihidrobenzosanton, furanodi hidrobenzosanton, piranodihidrobenzosanton, kuinonosanton, siklolopentenosanton, santonolid, dihidrosanton.

  2. Network analysis of metabolite GWAS hits

    DEFF Research Database (Denmark)

    Matone, Alice; Scott-Boyer, Marie-Pier; Carayol, Jerome

    2016-01-01

    . Altered plasma metabolites concentration could partly explain weight loss maintenance mechanisms. In the present work, a systems biology approach has been applied to investigate the potential mechanisms involved in weight loss maintenance within the Diogenes weight-loss intervention study. METHODS...... were associated with successful weight maintenance and with several SNPs within CPS1 (cis-eQTL). In order to contextualize these results, a gene-metabolite interaction network of CPS1 and glycine has been built and analyzed, showing functional enrichment in genes involved in lipid metabolism and one...

  3. Acceleration of intestinal polyposis through prostaglandin receptor EP2 in Apc(Delta 716) knockout mice.

    Science.gov (United States)

    Sonoshita, M; Takaku, K; Sasaki, N; Sugimoto, Y; Ushikubi, F; Narumiya, S; Oshima, M; Taketo, M M

    2001-09-01

    Arachidonic acid is metabolized to prostaglandin H(2) (PGH(2)) by cyclooxygenase (COX). COX-2, the inducible COX isozyme, has a key role in intestinal polyposis. Among the metabolites of PGH(2), PGE(2) is implicated in tumorigenesis because its level is markedly elevated in tissues of intestinal adenoma and colon cancer. Here we show that homozygous deletion of the gene encoding a cell-surface receptor of PGE(2), EP2, causes decreases in number and size of intestinal polyps in Apc(Delta 716) mice (a mouse model for human familial adenomatous polyposis). This effect is similar to that of COX-2 gene disruption. We also show that COX-2 expression is boosted by PGE(2) through the EP2 receptor via a positive feedback loop. Homozygous gene knockout for other PGE(2) receptors, EP1 or EP3, did not affect intestinal polyp formation in Apc(Delta 716) mice. We conclude that EP2 is the major receptor mediating the PGE2 signal generated by COX-2 upregulation in intestinal polyposis, and that increased cellular cAMP stimulates expression of more COX-2 and vascular endothelial growth factor in the polyp stroma.

  4. Analysis, testing, and evaluation of faulted and unfaulted Wye, Delta, and open Delta connected electromechanical actuators

    Science.gov (United States)

    Nehl, T. W.; Demerdash, N. A.

    1983-07-01

    Mathematical models capable of simulating the transient, steady state, and faulted performance characteristics of various brushless dc machine-PSA (power switching assembly) configurations were developed. These systems are intended for possible future use as primemovers in EMAs (electromechanical actuators) for flight control applications. These machine-PSA configurations include wye, delta, and open-delta connected systems. The research performed under this contract was initially broken down into the following six tasks: development of mathematical models for various machine-PSA configurations; experimental validation of the model for failure modes; experimental validation of the mathematical model for shorted turn-failure modes; tradeoff study; and documentation of results and methodology.

  5. Human pharmacokinetics of proguanil and its metabolites

    DEFF Research Database (Denmark)

    Bygbjerg, Ib Christian; Ravn, P; Rønn, A;

    1987-01-01

    The pharmacokinetics of proguanil and its metabolites cycloguanil and p-chlorophenylbiguanide were studied in five healthy volunteers taking 200 mg orally for 14 days. A highly sensitive and specific high-performance liquid chromatographic assay was applied, clearly identifying all three compound...

  6. Clinical chemistry of serotonin and metabolites

    NARCIS (Netherlands)

    Kema, IP; de Vries, EGE; Muskiet, FAJ

    2000-01-01

    Analyses of serotonin and other 5-hydroxyindoles, such as its precursor 5-hydroxytryptophan and major metabolite 5-hydroxyindoleacetic acid (5-HIAA), are indispensable for the elucidation of their (patho)physiological roles. In clinical chemistry attention is mainly focused on the diagnosis and foll

  7. Clinical chemistry of serotonin and metabolites

    NARCIS (Netherlands)

    Kema, IP; de Vries, EGE; Muskiet, FAJ

    2000-01-01

    Analyses of serotonin and other 5-hydroxyindoles, such as its precursor 5-hydroxytryptophan and major metabolite 5-hydroxyindoleacetic acid (5-HIAA), are indispensable for the elucidation of their (patho)physiological roles. In clinical chemistry attention is mainly focused on the diagnosis and

  8. Antiinflammatory and immunomodulating properties of fungal metabolites

    NARCIS (Netherlands)

    Lull Noguera, C.; Wichers, H.J.; Savelkoul, H.F.J.

    2005-01-01

    We discuss current information on the ability of extracts and isolated metabolites from mushrooms to modulate immune responses. This can result in a more enhanced innate and acquired disease resistance. The major immunomodulating effects of these active substances derived from mushrooms include mito

  9. A review: trichloroethylene metabolites: potential cardiac teratogens.

    Science.gov (United States)

    Johnson, P D; Dawson, B V; Goldberg, S J

    1998-08-01

    This review is a a series of the authors' studies designed to test the hypothesis that administration of trichloroethylene (TCE), dichloroethylene (DCE), their metabolites, and related compounds are responsible for fetal cardiac teratogenesis when given to pregnant rats during organogenesis. Identification of teratogenic compounds will allow more accurate assessment of environmental contaminants and public health risks. Epidemiologic studies and previous teratogenic studies using chick embryos and fetal rats have reported an increased number of congenital cardiac defects when exposed to TCE or DCE during fetal development. Metabolites of TCE and DCE studied in the drinking-water exposure study include trichloroacetic acid TCAA), monochloroacetic acid, trichloroethanol, carboxymethylcysteine, trichloroacetaldehyde, dichloroacetaldehyde, and dichlorovinyl cysteine. Varying doses of each were given in drinking water to pregnant rats during the period of fetal heart development. Rats receiving 2730 ppm TCAA in drinking water were the only metabolite group demonstrating a significant increase in the number of cardiac defects in fetuses on a per-litter basis (p = 0.0004 Wilcoxon test and p =0.0015 exact permutation test). Maternal and fetal variables showed no statistically significant differences between treated and untreated groups. When treated with TCAA the increased cardiac defects, as compared to controls, do not preclude the involvement of other metabolites as cardiac teratogens, but indicates TCAA as a specific cardiac teratogen. Further studies of drinking-water exposure and potential mechanisms of action on the developing heart are proceeding.

  10. The Membrane Gradostat Reactor: Secondary metabolite production ...

    African Journals Online (AJOL)

    SERVER

    2007-05-16

    May 16, 2007 ... gies are now well accepted and cost effective (Wiesner and Chellam ... uce these secondary metabolites continuously were .... and ammonium sources in the feed and permeates reco- .... when the solutions were fed through the lumen of the .... Progress from batch culture to a membrane bioreactor for the.

  11. Spatial distribution of metabolites in the human lens.

    Science.gov (United States)

    Tamara, Semen O; Yanshole, Lyudmila V; Yanshole, Vadim V; Fursova, Anjella Zh; Stepakov, Denis A; Novoselov, Vladimir P; Tsentalovich, Yuri P

    2016-02-01

    Spatial distribution of 34 metabolites along the optical and equatorial axes of the human lens has been determined. For the majority of metabolites, the homogeneous distribution has been observed. That suggests that the rate of the metabolite transformation in the lens is low due to the general metabolic passivity of the lens fiber cells. However, the redox processes are active in the lens; as a result, some metabolites, including antioxidants, demonstrate the "nucleus-depleted" type of distribution, whereas secondary UV filters show the "nucleus-enriched" type. The metabolite concentrations at the lens poles and equator are similar for all metabolites under study. The concentric pattern of the "nucleus-depleted" and "nucleus-enriched" distributions testifies that the metabolite distribution inside the lens is mostly governed by a passive diffusion, relatively free along the fiber cells and retarded in the radial direction across the cells. No significant difference in the metabolite distribution between the normal and cataractous human lenses was found.

  12. Discovering the secondary metabolite potential encoded within entomopathogenic fungi.

    Science.gov (United States)

    Gibson, Donna M; Donzelli, Bruno G G; Krasnoff, Stuart B; Keyhani, Nemat O

    2014-10-01

    This highlight discusses the secondary metabolite potential of the insect pathogens Metarhizium and Beauveria, including a bioinformatics analysis of secondary metabolite genes for which no products are yet identified.

  13. Antioxidant status, immune system, blood metabolites and carcass ...

    African Journals Online (AJOL)

    Antioxidant status, immune system, blood metabolites and carcass characteristic of broiler ... African Journal of Biotechnology ... rhizome powder (TP) on performance, blood metabolite, immune system, antioxidant status, and relative weight of ...

  14. The role of natural chlorinated hydroquinone metabolites in ligninolytic fungi

    NARCIS (Netherlands)

    Teunissen, P.J.M.

    1999-01-01

    Ligninolytic Basidiomycetes have been reported to produce a wide variety of chloroaromatic compounds as secondary metabolites, which are structurally similar to environmental pollutants. Among these are chlorinated hydroquinone metabolites (CHM), such as 2-chloro-1,4-dimethoxybenzene

  15. Tidal river dynamics: Implications for deltas

    Science.gov (United States)

    Hoitink, A. J. F.; Jay, D. A.

    2016-03-01

    Tidal rivers are a vital and little studied nexus between physical oceanography and hydrology. It is only in the last few decades that substantial research efforts have been focused on the interactions of river discharge with tidal waves and storm surges into regions beyond the limit of salinity intrusion, a realm that can extend inland hundreds of kilometers. One key phenomenon resulting from this interaction is the emergence of large fortnightly tides, which are forced long waves with amplitudes that may increase beyond the point where astronomical tides have become extinct. These can be larger than the linear tide itself at more landward locations, and they greatly influence tidal river water levels and wetland inundation. Exploration of the spectral redistribution and attenuation of tidal energy in rivers has led to new appreciation of a wide range of consequences for fluvial and coastal sedimentology, delta evolution, wetland conservation, and salinity intrusion under the influence of sea level rise and delta subsidence. Modern research aims at unifying traditional harmonic tidal analysis, nonparametric regression techniques, and the existing understanding of tidal hydrodynamics to better predict and model tidal river dynamics both in single-thread channels and in branching channel networks. In this context, this review summarizes results from field observations and modeling studies set in tidal river environments as diverse as the Amazon in Brazil, the Columbia, Fraser and Saint Lawrence in North America, the Yangtze and Pearl in China, and the Berau and Mahakam in Indonesia. A description of state-of-the-art methods for a comprehensive analysis of water levels, wave propagation, discharges, and inundation extent in tidal rivers is provided. Implications for lowland river deltas are also discussed in terms of sedimentary deposits, channel bifurcation, avulsion, and salinity intrusion, addressing contemporary research challenges.

  16. THE RURAL TOURISM IN DANUBE DELTA

    Directory of Open Access Journals (Sweden)

    Ionica SOARE

    2014-06-01

    Full Text Available Purpose - the purpose of this paper is to evaluate the rural areas has market size and forecast its development as an economic activity. The present paper aims at analyzing the rural areas has in Danube Delta. In an enviable BAs which have responsibility for their particular isolated, such as the Danube Delta and the Danube that used, fishing and rural areas has the main activities that provide jobs and income sources for local populations. Design/methodology/approach - A survey was administered to customers’ rural hostel accommodation in Danube Delta. Descriptive statistics method was mainly adopted to calculate the mean with standard deviation of entry assumes variable, and to examine the different levels of consumers' awareness. The index values of product familiarity, the ratio between entries assumes product's familiarity value and the average value. Findings - the research results show hash has rural consumers have different perception and accomplished through behaviour. The information channels of brand hash mainly from friends, relatives and neighbours, so word of mouth spreading is very important for a brand. Women show a higher sensitivity in health and are currently operating the propensity than referred to follow the recommendations for nutrition. Research limitations/implications - This item is intended to synthesize developments and challenges," on June 13th rural market growth has. The results of this paper should be considered tentatively until has also features replicated by larger has rural consumers. Originality/value - members of rural areas has consumer's behavior would improve marketing and the development of rural areas has products, in order to reduce consumer confusion.

  17. Delta Shell: Integrated Modeling by Example

    Science.gov (United States)

    Donchyts, G.; Jagers, B.; Baart, F.; Geer, P. V.

    2011-12-01

    We present the integrated modeling environment Delta Shell. It supports the full workflow of integrated environmental modeling: setup, configuration, simulation, analysis and reporting of results. Many components of the environment can be reused independently, allowing development of scientific, geospatial and other applications focused on data analysis, editing, visualization and storage. One of the unique features is that the Delta Shell environment integrates models from many different fields, such as hydrodynamics, hydrology, morphology, ecology, water quality, geospatial and decision support systems. This integration is possible due to flexible general data types, lightweight model coupling framework, the plugin system and the inclusion of a number of high quality open source components. Here we will use the open source morphological model XBeach as an example showing how to integrate models into the Delta Shell environment. Integration of XBeach adds a graphical interface which can be used to make testing coastal safety for complicated coastal areas easier. By using this example, we give an overview of the modeling framework and its possibilities. To increase the usability, the model is integrated with a coastal profile data set covering the whole coast of the Netherlands. This gives the end user a system to easily use the model for scanning the safety of the Dutch coast. The reuse of the components of the environment individually or combined is encouraged. They are available as separate components and have minimal or no dependencies on other components. This includes libraries to work with scientific multidimensional data, geospatial data (in particular geospatial coverages: values of some quantities defined on a spatial domain), editors, visualisation of time-dependent data and the modeling framework (projects, data linking, workflow management, model integration). Most components and the XBeach example are available as open source.

  18. Upper-division student difficulties with the Dirac delta function

    CERN Document Server

    Wilcox, Bethany R

    2015-01-01

    The Dirac delta function is a standard mathematical tool that appears repeatedly in the undergraduate physics curriculum in multiple topical areas including electrostatics, and quantum mechanics. While Dirac delta functions are often introduced in order to simplify a problem mathematically, students still struggle to manipulate and interpret them. To characterize student difficulties with the delta function at the upper-division level, we examined students' responses to traditional exam questions and a standardized conceptual assessment, and conducted think-aloud interviews. Our analysis was guided by an analytical framework that focuses on how students activate, construct, execute, and reflect on the Dirac delta function in the context of problem solving in physics. Here, we focus on student difficulties using the delta function to express charge distributions in the context of junior-level electrostatics. Common challenges included: invoking the delta function spontaneously, translating a description of a c...

  19. Compositeness of the Delta(1232) resonance in pi N scattering

    CERN Document Server

    Sekihara, Takayasu; Yamagata-Sekihara, Junko; Yasui, Shigehiro

    2015-01-01

    We evaluate the $\\pi N$ compositeness of the $\\Delta (1232)$ resonance so as to clarify the internal structure of $\\Delta (1232)$ in terms of the $\\pi N$ component. Here the compositeness is defined as contributions from two-body wave functions to the normalization of the total wave function and is extracted from the $\\pi N$ scattering amplitude. In this study we employ the chiral unitary approach with the interaction up to the next-to-leading order plus a bare $\\Delta$ term in chiral perturbation theory and describe $\\Delta (1232)$ in an elastic $\\pi N$ scattering. Fitting the $\\pi N$ scattering amplitude to the solution of the partial wave analysis, we obtain a large real part of the $\\pi N$ compositeness for $\\Delta (1232)$ comparable to unity and non-negligible imaginary part as well, with which we reconfirm the result in the previous study on the $\\pi N$ compositeness for $\\Delta (1232)$.

  20. A defect in the activity of Delta6 and Delta5 desaturases may be a factor predisposing to the development of insulin resistance syndrome.

    Science.gov (United States)

    Das, Undurti N

    2005-05-01

    GLUT-4 (glucose transporter) receptor, tumor necrosis factor-alpha (TNF-alpha), interleukins-6 (IL-6), daf-genes and PPARs (peroxisomal proliferation activator receptors) play a role in the development of insulin resistance syndrome and associated conditions. But, the exact interaction between these molecules/factors and the mechanism(s) by which they produce insulin resistance syndrome is not clear. I propose that a defect in the activity of the enzymes Delta6 and Delta5 desaturases that are essential for the formation of long chain metabolites of essential fatty acids, linoleic acid and alpha-linolenic acid, is a factor in the development of insulin resistance syndrome. Long chain polyunsaturated fatty acids (LCPUFAs) increase cell membrane fluidity and enhance the number of insulin receptors and the affinity of insulin to its receptors; suppress TNF-alpha, IL-6, macrophage migration inhibitory factor (MIF) and leptin synthesis; increase the number of GLUT-4 receptors, serve as endogenous ligands of PPARs, modify lipolysis, and regulate the balance between pro- and anti-oxidants, and thus, play a critical role in the pathogenesis of insulin resistance. In the nematode, Caenorhabditis elegans, the protein encoded by daf-2 is 35% identical to the human insulin receptor; daf-7 codes a transforming growth factor-beta (TGF-beta) type signal and daf-16 enhances superoxide dismutase (SOD) expression. Melatonin has anti-oxidant actions similar to daf-16, TGF-beta and SOD. Calorie restriction enhances the activity of Delta6 and Delta5 desaturases, melatonin production, decreases daf-2 signaling, free radical generation, and augments anti-oxidant defenses that may explain the beneficial effect of diet control in the management of obesity, insulin resistance, and type II diabetes mellitus. These evidences suggest that the activities of Delta6 and Delta5 enzymes play a critical role in the expression and regulation of GLUT-4, TNF-alpha, IL-6, MIF, daf-genes, melatonin, and

  1. Monitoring the Polarimetric Variability of \\delta\\ Scorpii

    CERN Document Server

    Bednarski, Daniel

    2012-01-01

    The Be star \\delta\\ Scorpii is an interesting binary system, whose primary companion created a circumstellar disk after the periastron passage of the secondary in 2000, being since then classified as Be. This work presents the results of a long-term monitoring of this star in broad-band imaging polarimetry. The observational data collected since 2006 in the Pico dos Dias Observatory (Brazil) show a variable polarization that seems to correlate with the photometric light curve. From this data we see that the disk density varied since 2006; furthermore, the data suggests that there was some disturbance of the disk during the last periastron passage in July, 2011.

  2. Error Minimization of Polynomial Approximation of Delta

    Indian Academy of Sciences (India)

    Islam Sana; Sadiq Muhammad; Qureshi Muhammad Shahid

    2008-09-01

    The difference between Universal time (UT) and Dynamical time (TD), known as Delta ( ) is tabulated for the first day of each year in the Astronomical Almanac. During the last four centuries it is found that there are large differences between its values for two consecutive years. Polynomial approximations have been developed to obtain the values of for any time of a year for the period AD 1620 to AD 2000 (Meeu 2000) as no dynamical theories describe the variations in . In this work, a new set of polynomials for is obtained for the period AD 1620 to AD 2007 that is found to produce better results compared to previous attempts.

  3. International Financial Centers Delta in China

    Institute of Scientific and Technical Information of China (English)

    Emily Yu

    2009-01-01

    @@ It has called a lot of attention tnat China should build a pattern of International Financial Centers Delta:Make Beijing the centre of International Finance Management and Cooperation,working as the management and cooperation base and headquarter for China's participation in the iriternational Financial competition;Make Shanghai the centre of International Finance Market.working as the main battlefield of China's participation in international financial competition;Make Hong Kong the centre of Intemational Finance Open and Innovation,working as the frontier of China's participation in international financial competition.

  4. Hepatitis Delta Virus: A Peculiar Virus

    OpenAIRE

    Carolina Alves; Cristina Branco; Celso Cunha

    2013-01-01

    The hepatitis delta virus (HDV) is distributed worldwide and related to the most severe form of viral hepatitis. HDV is a satellite RNA virus dependent on hepatitis B surface antigens to assemble its envelope and thus form new virions and propagate infection. HDV has a small 1.7 Kb genome making it the smallest known human virus. This deceivingly simple virus has unique biological features and many aspects of its life cycle remain elusive. The present review endeavors to gather the available ...

  5. Qualitative and quantitative determination of drotaverine metabolites in rat bile.

    Science.gov (United States)

    Vargay, Z; Simon, G; Winter, M; Szüts, T

    1980-01-01

    After oral and intravenous administration of drotaverin-14C its metabolites were determined in rat bile. Three major metabolites were identified by tlc. All the metabolites appeared in conjugated form. No unchanged drotaverine was detectable in the bile, except after treatment with doses much in excess of the therapeutic range. The ratio of major metabolites to unchanged product was determined by two-dimensional densitometry using a Telechrom Video Densitometer.

  6. Stratigraphy and Evolution of Delta Channel Deposits, Jezero Crater, Mars

    Science.gov (United States)

    Goudge, T. A.; Mohrig, D.; Cardenas, B. T.; Hughes, C. M.; Fassett, C. I.

    2017-01-01

    The Jezero impact crater hosted an open-basin lake that was active during the valley network forming era on early Mars. This basin contains a well exposed delta deposit at the mouth of the western inlet valley. The fluvial stratigraphy of this deposit provides a record of the channels that built the delta over time. Here we describe observations of the stratigraphy of the channel deposits of the Jezero western delta to help reconstruct its evolution.

  7. Delta Doping High Purity CCDs and CMOS for LSST

    Science.gov (United States)

    Blacksberg, Jordana; Nikzad, Shouleh; Hoenk, Michael; Elliott, S. Tom; Bebek, Chris; Holland, Steve; Kolbe, Bill

    2006-01-01

    A viewgraph presentation describing delta doping high purity CCD's and CMOS for LSST is shown. The topics include: 1) Overview of JPL s versatile back-surface process for CCDs and CMOS; 2) Application to SNAP and ORION missions; 3) Delta doping as a back-surface electrode for fully depleted LBNL CCDs; 4) Delta doping high purity CCDs for SNAP and ORION; 5) JPL CMP thinning process development; and 6) Antireflection coating process development.

  8. Delta Plaza kohvik = The Delta Plaza Café / Margit Mutso

    Index Scriptorium Estoniae

    Mutso, Margit, 1966-

    2010-01-01

    Tallinnas Pärnu mnt. 141 asuva kohviku Delta Plaza sisekujundusest. Sisearhitektid Tiiu Truus ja Marja Viltrop (Stuudio Truus OÜ). Hoone arhitektid Jüri Okas ja Marika Lõoke (AB J. Okas & M. Lõoke). Žürii liikme Mait Summataveti arvamus kohvikust

  9. Global Heat Kernel Estimates for $\\Delta+\\Delta^{\\alpha/2}$ in Half-space-like domains

    CERN Document Server

    Chen, Zhen-Qing; Song, Renming

    2011-01-01

    Suppose that $d\\ge 1$ and $\\alpha\\in (0, 2)$. In this paper, by using probabilistic methods, we establish sharp two-sided pointwise estimates for the Dirichlet heat kernels of $\\{\\Delta+ a^\\alpha \\Delta^{\\alpha/2}; \\ a\\in (0, 1]\\}$ on half-space-like $C^{1, 1}$ domains in ${\\mathbb R}^d$ for all time $t>0$. The large time estimates for half-space-like domains are very different from those for bounded domains. Our estimates are uniform in $a \\in (0, 1]$ in the sense that the constants in the estimates are independent of $a\\in (0, 1]$. Thus it yields the Dirichlet heat kernel estimates for Brownian motion in half-space-like domains by taking $a\\to 0$. Integrating the heat kernel estimates in time $t$, we obtain uniform sharp two-sided estimates for the Green functions of $\\{\\Delta+ a^\\alpha \\Delta^{\\alpha/2}; \\ a\\in (0, 1]\\}$ in half-space-like $C^{1, 1}$ domains in ${\\mathbb R}^d$.

  10. Delta Plaza kohvik = The Delta Plaza Café / Margit Mutso

    Index Scriptorium Estoniae

    Mutso, Margit, 1966-

    2010-01-01

    Tallinnas Pärnu mnt. 141 asuva kohviku Delta Plaza sisekujundusest. Sisearhitektid Tiiu Truus ja Marja Viltrop (Stuudio Truus OÜ). Hoone arhitektid Jüri Okas ja Marika Lõoke (AB J. Okas & M. Lõoke). Žürii liikme Mait Summataveti arvamus kohvikust

  11. Hydraulic Geometry of a tidally influenced delta channel network: the Mahakam Delta, East Kalimantan, Indonesia

    Science.gov (United States)

    Sassi, M.; Hoitink, A.; de Brye, B.; Deleersnijder, E.

    2011-12-01

    Hydraulic Geometry (HG) refers to relations between the characteristics of channels in a network, including mean depth, width, and bed slope, and the discharge conveyed by the channel during bank-full conditions. HG relations are of fundamental importance to water management in channel networks, and they bear an interesting relation with geomorphology. River delta channel networks typically scale according to HG relations such as log(A) ~ p*log(Q), where A is channel cross sectional area, Q water discharge, and the exponent p is in between 0.8 and 1.2. In tidal networks, the tidal prism or tidal discharge can be used, instead of a discharge with a constant frequency of occurrence. In the tidal case, the exponent often shows the same range of variation. Tidal rivers are intrinsically complex, as tidal propagation is influenced by river discharge and vice-versa. Consequently, channel geometry in tidally influenced river deltas may show a mixed scaling behavior of river and tidal channel networks, as the channel forming discharges may both be of river and tidal origin. In tidal regions, the tidal dynamics may lead to a cyclic variation in water discharge distribution at bifurcations, readily affecting HG relations. We present results from the Mahakam delta channel network in Indonesia, a tide-river dominated delta which has been prograding for 60 km over the last 5000 years. Bathymetric surveys were conducted over the distributary network and connected tidal channels. Based on a geomorphic analysis of the present distributary network, we show that channel geometry of the fluvial distributary network scales with bifurcation order. The bifurcation order does not feature a clear relation with bifurcate branch length or bifurcate width ratio, as in the case of river deltas. HG relations of the area of selected cross-sections are well represented by the tidal prism or by the river discharge, when scaled with the bifurcation order. Numerical simulations show that river

  12. Non-peptide metabolites from the genus Bacillus.

    Science.gov (United States)

    Hamdache, Ahlem; Lamarti, Ahmed; Aleu, Josefina; Collado, Isidro G

    2011-04-25

    Bacillus species produce a number of non-peptide metabolites that display a broad spectrum of activity and structurally diverse bioactive chemical structures. Biosynthetic, biological, and structural studies of these metabolites isolated from Bacillus species are reviewed. This contribution also includes a detailed study of the activity of the metabolites described, especially their role in biological control mechanisms.

  13. SPE-NMR metabolite sub-profiling of urine

    NARCIS (Netherlands)

    Jacobs, D.M.; Spiesser, L.; Garnier, M.; Roo, de N.; Dorsten, van F.; Hollebrands, B.; Velzen, van E.; Draijer, R.; Duynhoven, van J.P.M.

    2012-01-01

    NMR-based metabolite profiling of urine is a fast and reproducible method for detection of numerous metabolites with diverse chemical properties. However, signal overlap in the (1)H NMR profiles of human urine may hamper quantification and identification of metabolites. Therefore, a new method has b

  14. SPE-NMR metabolite sub-profiling of urine

    NARCIS (Netherlands)

    Jacobs, D.M.; Spiesser, L.; Garnier, M.; Roo, de N.; Dorsten, van F.; Hollebrands, B.; Velzen, van E.; Draijer, R.; Duynhoven, van J.P.M.

    2012-01-01

    NMR-based metabolite profiling of urine is a fast and reproducible method for detection of numerous metabolites with diverse chemical properties. However, signal overlap in the (1)H NMR profiles of human urine may hamper quantification and identification of metabolites. Therefore, a new method has

  15. QCD corrections to inclusive $\\Delta S=1,2$ transitions

    OpenAIRE

    Jamin, Matthias

    1994-01-01

    The talk summarises a calculation of the two-point functions for $\\Delta S=1$ current-current and QCD-penguin operators, as well as for the $\\Delta S=2$ operator, at the next-to-leading order. The size of the gluonic corrections to current-current operators is large, providing a qualitative understanding of the observed enhancement in $\\Delta I=1/2$ transitions. In the $\\Delta S=2$ sector the QCD corrections are quite moderate ($\\approx -20\\%$). This work has been done in collaboration with A...

  16. [A study of 158 cases of acute delta hepatitis].

    Science.gov (United States)

    Castro, A; Buti, M; Esteban, R; Jardí, R; Allende, H; Roget, M; Rodríguez-Frías, F; Guardia, J

    1990-09-22

    We have prospectively studied 158 cases of acute hepatitis delta observed during the last 7 years in a general hospital. Among them 136 were male and 22 female. The mean age was 22.7 years with a range between 16 and 61 years. The epidemiologic factors were drug addiction by parenteral route in 145 cases (92%), sexual transmission in 5 (3%), post transfusional in 2 (1%) and unknown in 6 (4%). With respect to the delta type infection, 105 cases (66%) were coinfections with type B and delta, and 53 patients had a type delta superinfection (34%). The clinical course was a fulminant hepatitis in three cases (two cases of coinfection B and delta an one case of delta superinfection), and an acute benign hepatitis in 155 patients. The follow-up of 118 patients revealed that 96% of coinfections by type B and delta evolved to the chronicity showing findings of active chronic hepatitis or hepatic cirrhosis. It should be noted that in 4 cases of superinfection delta type (11%) the HBsAg was negative after several months of positivity. In these patients the level of transaminases normalized and the hepatic histology evidenced alterations of chronic active hepatitis (2 cases) and hepatic cirrhosis (2 cases) without identification of tissular delta antigen.

  17. A global analysis of human habitation on river deltas

    Science.gov (United States)

    Edmonds, Douglas; Caldwell, Rebecca; Baumgardner, Sarah; Paola, Chris; Roy, Samapriya; Nelson, Amelia; Nienhuis, Jaap

    2017-04-01

    River deltas are ideal sites for human habitation because of their fertile floodplains, easy access to the ocean, and abundant land. But anthropogenic and natural processes are causing deltas to sink, which increases the probability of coastal flooding and human exposure to risk. The full extent of the risk posed to humans is unclear because the number of people living on river deltas is unknown. Towards this end we mapped the locations and areas of all deltas in the world (n= 1813). Using Google Earth we identified all river mouths (≥ 50 m wide) on marine coastlines that are also connected to an upstream catchment. Rivers that split into two or more active or relict distributary channels, end in a depositional protrusion from the shoreline, or do both, are defined as deltas. The depositional protrusion and distributary channel network define the geomorphic area of each delta. We mark the position of the delta apex at the first bifurcation, or for a single channel delta at the intersection of the regional shoreline and the main channel. We mark three lateral extents, one on either side of the main channel at the maximum displacement of the depositional protrusion or the distributary network, and one on the most basinward position of the delta. We define delta area as the convex hull around these extent points and the delta apex. For each delta area polygon we extract elevation from the Shuttle Radar Topography Mission dataset and population count in years 2000, 2005, 2010, 2015, and 2020 from Gridded Population of the World, version 4. In total, deltas cover 0.56% of the total area of the world yet contain 4.1% of the world's population. The population on deltas has grown from 237 million in 2000 to projected values of 322 million in 2020. Deltaic population is growing at 1.59% per year, which outpaces the world growth rate of 1.11%. Additionally, population density is increasing with time from 322 people per km2 in year 2000 to projected values of 422 people per

  18. Superconducting bandpass delta-sigma modulator

    Science.gov (United States)

    Bulzacchelli, J. F.; Lee, H.-S.; Misewich, J. A.; Ketchen, M. B.

    1999-11-01

    Bandpass delta-sigma modulators digitize narrowband signals with high dynamic range and linearity. The required sampling rate is only a few times higher than the centre frequency of the input. This paper presents a superconducting bandpass delta-sigma modulator for direct analogue-to-digital conversion of RF signals in the GHz range. The input signal is capacitively coupled to one end of a microstrip transmission line, and a single flux quantum balanced comparator quantizes the current flowing out of the other end. Quantization noise is suppressed at the quarter-wave resonance of the transmission line (about 2 GHz in our design). Circuit performance at a 20 GHz sampling rate has been studied with several long JSIM simulations. Full-scale (FS) input sensitivity is 20 mV (rms), and in-band noise is -53 dBFS and -57 dBFS over bandwidths of 39 MHz and 19.5 MHz, respectively. In-band intermodulation distortion is better than -69 dBFS.

  19. Superconducting bandpass delta-sigma modulator

    Energy Technology Data Exchange (ETDEWEB)

    Bulzacchelli, J.F.; Lee, H.-S. [Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139 (United States); Misewich, J.A.; Ketchen, M.B. [IBM Research Division, T. J. Watson Research Center, Yorktown Heights, NY 10598 (United States)

    1999-11-01

    Bandpass delta-sigma modulators digitize narrowband signals with high dynamic range and linearity. The required sampling rate is only a few times higher than the centre frequency of the input. This paper presents a superconducting bandpass delta-sigma modulator for direct analogue-to-digital conversion of RF signals in the GHz range. The input signal is capacitively coupled to one end of a microstrip transmission line, and a single flux quantum balanced comparator quantizes the current flowing out of the other end. Quantization noise is suppressed at the quarter-wave resonance of the transmission line (about 2 GHz in our design). Circuit performance at a 20 GHz sampling rate has been studied with several long JSIM simulations. Full-scale (FS) input sensitivity is 20 mV (rms), and in-band noise is -53 dBFS and -57 dBFS over bandwidths of 39 MHz and 19.5 MHz, respectively. In-band intermodulation distortion is better than -69 dBFS. (author)

  20. Catalyzing action towards the sustainability of deltas: deltas as integrated socio-ecological systems and sentinels of regional and global change

    Science.gov (United States)

    Foufoula-Georgiou, E.; Tessler, Z. D.; Brondizio, E.; Overeem, I.; Renaud, F.; Sebesvari, Z.; Nicholls, R. J.; Anthony, E.

    2016-12-01

    Deltas are highly dynamic and productive environments: they are food baskets of the world, home to biodiverse and rich ecosystems, and they play a central role in food and water security. However, they are becoming increasingly vulnerable to risks arising from human activities, land subsidence, regional water management, global sea-level rise, and climate extremes. Our Belmont Forum DELTAS project (BF-DELTAS: Catalyzing actions towards delta sustainability) encompasses an international network of interdisciplinary research collaborators with focal areas in the Mekong, Ganges Brahmaputra, and the Amazon deltas. The project is organized around five main modules: (1) developing an analytical framework for assessing delta vulnerability and scenarios of change (Delta-SRES), (2) developing an open-acess, science-based integrative modeling framework for risk assessment and decision support (Delta-RADS), (3) developing tools to support quantitative mapping of the bio-physical and socio-economic environments of deltas and consolidate bio-physical and social data within shared data repositories (Delta-DAT), (4) developing Global Delta Vulnerability Indices (Delta-GDVI) that capture current and projected scenarios for major deltas around the world , and (5) collaborating with regional stakeholders to put the science, modeling, and data into action (Delta-ACT). In this talk, a research summary will be presented on three research domains around which significant collaborative work was developed: advancing biophysical classification of deltas, understanding deltas as coupled socio-ecological systems, and analyzing and informing social and environmental vulnerabilities in delta regions.

  1. delta13C and delta18O trends across overstory environments in whole foliage and cellulose of three Pinus species.

    Science.gov (United States)

    Powers, Matthew D; Pregitzer, Kurt S; Palik, Brian J

    2008-09-01

    Stable isotope ratios of carbon (delta(13)C) and oxygen (delta(18)O) are increasingly used to investigate environmental influences on plant physiology. Cellulose is often isolated for isotopic studies, but some authors have questioned the value of this process. We studied trends in delta(13)C and delta(18)O of whole foliage and holocellulose from seedlings of three Pinus species across three overstory environments to evaluate the benefits of holocellulose extraction in the context of a traditional ecological experiment. Both tissue types showed increasing delta(13)C from closed-canopy controls to thinned plots to 0.3 ha canopy gaps, and no change in delta(18)O between overstory environments. delta(13)C of P. resinosa and P. strobus was greater than delta(13)C of P. banksiana in whole foliage and holocellulose samples, and there were no differences in delta(18)O associated with species in either tissue type. Our results suggest whole foliage and holocellulose provide similar information about isotopic trends across broad environmental gradients and between species, but holocellulose may be better suited for studying differences in stable isotope composition between multiple species across several treatments.

  2. Novel bioactive metabolites of dipyrone (metamizol).

    Science.gov (United States)

    Rogosch, Tobias; Sinning, Christian; Podlewski, Agnes; Watzer, Bernhard; Schlosburg, Joel; Lichtman, Aron H; Cascio, Maria G; Bisogno, Tiziana; Di Marzo, Vincenzo; Nüsing, Rolf; Imming, Peter

    2012-01-01

    Dipyrone is a common antipyretic drug and the most popular non-opioid analgesic in many countries. In spite of its long and widespread use, molecular details of its fate in the body are not fully known. We administered dipyrone orally to mice. Two unknown metabolites were found, viz. the arachidonoyl amides of the known major dipyrone metabolites, 4-methylaminoantipyrine (2) and 4-aminoantipyrine (3). They were identified by ESI-LC-MS/MS after extraction from the CNS, and comparison with reference substances prepared synthetically. The arachidonoyl amides were positively tested for cannabis receptor binding (CB(1) and CB(2)) and cyclooxygenase inhibition (COX-1 and COX-2 in tissues and as isolated enzymes), suggesting that the endogenous cannabinoid system may play a role in the effects of dipyrone against pain. Copyright © 2011 Elsevier Ltd. All rights reserved.

  3. Biologically Active Metabolites Synthesized by Microalgae

    Science.gov (United States)

    de Morais, Michele Greque; Vaz, Bruna da Silva; de Morais, Etiele Greque; Costa, Jorge Alberto Vieira

    2015-01-01

    Microalgae are microorganisms that have different morphological, physiological, and genetic traits that confer the ability to produce different biologically active metabolites. Microalgal biotechnology has become a subject of study for various fields, due to the varied bioproducts that can be obtained from these microorganisms. When microalgal cultivation processes are better understood, microalgae can become an environmentally friendly and economically viable source of compounds of interest, because production can be optimized in a controlled culture. The bioactive compounds derived from microalgae have anti-inflammatory, antimicrobial, and antioxidant activities, among others. Furthermore, these microorganisms have the ability to promote health and reduce the risk of the development of degenerative diseases. In this context, the aim of this review is to discuss bioactive metabolites produced by microalgae for possible applications in the life sciences. PMID:26339647

  4. Deep Sea Actinomycetes and Their Secondary Metabolites

    Directory of Open Access Journals (Sweden)

    Kui Hong

    2017-05-01

    Full Text Available Deep sea is a unique and extreme environment. It is a hot spot for hunting marine actinomycetes resources and secondary metabolites. The novel deep sea actinomycete species reported from 2006 to 2016 including 21 species under 13 genera with the maximum number from Microbacterium, followed by Dermacoccus, Streptomyces and Verrucosispora, and one novel species for the other 9 genera. Eight genera of actinomycetes were reported to produce secondary metabolites, among which Streptomyces is the richest producer. Most of the compounds produced by the deep sea actinomycetes presented antimicrobial and anti-cancer cell activities. Gene clusters related to biosynthesis of desotamide, heronamide, and lobophorin have been identified from the deep sea derived Streptomyces.

  5. The neurotoxicity of pyridinium metabolites of haloperidol

    Directory of Open Access Journals (Sweden)

    Agnieszka Górska

    2015-10-01

    Full Text Available Haloperydol is a butyrophenone, typical neuroleptic agent characterized as a high antipsychotics effects in the treatment of schizophrenia and in palliative care to alleviation many syndromes, such as naursea, vomiting and delirium. Clinical problems occurs during and after administration of the drug are side effects, particularly extrapyrramidal symptoms (EPS. The neurotoxicity of haloperydol may be initiated by the cationic metabolites of haloperydol, HPP+, RHPP+, formed by oxidation and reduction pathways. These metabolites are transported by human organic cation transporters (hOCT to several brain structures for exapmle, in substantia nigra, striatum, caudate nucleus, hippocampus. After reaching the dopaminergic neurons inhibits mitochondrial complex I, evidence for free radical involvement, thus leading to neurodegeneration.

  6. Metabolite production by differnt Ulocladium species

    DEFF Research Database (Denmark)

    Andersen, Birgitte; Hollensted, Morten

    2008-01-01

    Ulocladium, which is phylogenetically related to Alternaria, contains species that are food spoilers and plant pathogens, but also species that have potential as enzyme producers and bio-control agents. Ulocladium spp. are often found on dead vegetation, in soil, air and dust, but also on food...... and feedstuffs and on water-damaged building materials. The aim was to study the morphological and chemical diversity within the genus Ulocladium. Cultures of 52 Ulocladium strains were identified morphologically, and then extracted and analyzed using automated Chemical Image Analysis. Production of individual...... metabolites was correlated to species identity and source of isolation (substratum). Chemical analyses corroborated the morphological identifications and showed the existence of several species species-specific metabolites, of which most were known Compounds. The production of curvularins was specific...

  7. Biologically Active Metabolites Synthesized by Microalgae

    Directory of Open Access Journals (Sweden)

    Michele Greque de Morais

    2015-01-01

    Full Text Available Microalgae are microorganisms that have different morphological, physiological, and genetic traits that confer the ability to produce different biologically active metabolites. Microalgal biotechnology has become a subject of study for various fields, due to the varied bioproducts that can be obtained from these microorganisms. When microalgal cultivation processes are better understood, microalgae can become an environmentally friendly and economically viable source of compounds of interest, because production can be optimized in a controlled culture. The bioactive compounds derived from microalgae have anti-inflammatory, antimicrobial, and antioxidant activities, among others. Furthermore, these microorganisms have the ability to promote health and reduce the risk of the development of degenerative diseases. In this context, the aim of this review is to discuss bioactive metabolites produced by microalgae for possible applications in the life sciences.

  8. Differences in urinary trichloroethylene metabolites of animals.

    Directory of Open Access Journals (Sweden)

    Ogata,Masana

    1979-12-01

    Full Text Available Differences in urinary excretion of trichloroethylene were studied in rabbits, rats and mice. Trichloretylene (1 m mole/kg was injected intra-peritoneally, then urinary trichloroacetic acid and trichloroethanol glucuronide were measured. The results were: 1. The ratio of total excretion of trichloroethylene metabolites to the administered trichloroethylene decreased in the order of mice, rats and rabbits. 2. The ratio of total trichloroethanol to trichloroacetic acid in urine decreased in the order of rabbits (69.2, mice (12.8 and rats (2.3. The high ratio in rabbits was due to the extremely small amount of trichloroacetic acid in the urine. 3. Differences in these two urinary metabolites in the three kinds of animals and in human subjects were discussed.

  9. Multidecadal Fluvial Sediment Fluxes to Deltas under Environmental Change Scenarios

    Science.gov (United States)

    Dunn, Frances; Darby, Stephen; Nicholls, Robert

    2016-04-01

    Sediment delivery is vital to sustain delta environments on which over half a billion people live worldwide. Due to factors such as subsidence and sea level rise, deltas sink relative to sea level if sediment is not delivered to and retained on their surfaces. Deltas which sink relative to sea level experience flooding, land degradation and loss, which endangers anthropogenic activities and populations. The future of fluvial sediment fluxes, a key mechanism for sediment delivery to deltas, is uncertain due to complex environmental changes which are predicted to occur over the coming decades. This research investigates fluvial sediment fluxes under environmental changes in order to assess the sustainability of delta environments under potential future scenarios up to 2100. Global datasets of climate change, reservoir construction, and population and GDP as proxies for anthropogenic influence through land use changes are used to drive the catchment numerical model WBMsed, which is being used to investigate the effects of these environmental changes on fluvial sediment delivery. This process produces fluvial sediment fluxes under multiple future scenarios which will be used to assess the future sustainability of a selection of 8 vulnerable deltas, although the approach can be applied to deltas worldwide. By modelling potential future scenarios of fluvial sediment flux, this research contributes to the prognosis for delta environments. The future scenarios will inform management at multiple temporal scales, and indicate the potential consequences for deltas of various anthropogenic activities. This research will both forewarn managers of potentially unsustainable deltas and indicate those anthropogenic activities which encourage or hinder the creation of sustainable delta environments.

  10. Indoor fungi and their ciliostatic metabolites.

    Science.gov (United States)

    Piecková, Elena; Kunová, Zuzana

    2002-01-01

    According to epidemiological studies, it is possible that some secondary metabolites of indoor airborne fungi could be responsible for health troubles which occupants suffer from. In our previous experiments, a model with tracheal rings of 1-day-old chicks in vitro was shown to be a very suitable method to study the ciliostatic chloroform-extractable endo- and/or exometabolites of filamentous fungi. In this study we isolated the filamentous fungi from walls of "mouldy" dwellings and schools (cultivation on dichloran 18% glycerol agar at 25 and 37 degrees C for 10 d) in Slovakia. We studied the ciliostatic effect of the chloroform-extractable endo- and exometabolites of 96 representative isolates (stationary cultivation on the liquid medium with 2% of yeast extract and 10% of sucrose at 25 degrees C for 10 days) on the cilia movement in tracheal organ cultures of 1-day-old chickens in vitro after 24, 48 and 72 hrs (incubation in the minimal essential medium according to Eagle with Earl s salts and 20 microg of extract of metabolites dissolved in dimethylsulfoxide per 1 mL). Strains of Penicillium Link: Fr. sp., Aspergillus versicolor (Vuill.) Tiraboschi, A. flavus Link, Cladosporium sphaerospermum Penzig and C. cladosporioides (Fres.) de Vries were isolated most frequently. Two A. flavus isolates were able to produce aflatoxins B1, B2, G1, G2 in vitro after cultivation on the liquid medium with 20% sucrose and 2% yeast extract. This is the first isolation of aflatoxigenic A. flavus strains from dwellings in Slovakia. All frequently isolated strains produced secondary metabolites with the strongest ciliostatic activity -- their exo- and endometabolites stopped tracheal ciliary movement in chicks till 24 h. There are some toxic fungal metabolites in the indoor air not only with the ability to destroy ciliary movement in the upper airways in vitro but, probably, during long-lasting exposure to cause general intoxication of macroorganism via lung tissue.

  11. Three new metabolites from Botrytis cinerea.

    Science.gov (United States)

    Wang, Tian-Shan; Zhou, Jin-Yan; Tan, Hong

    2008-01-01

    Three new metabolites, gamma-abscisolactone (1), botrytisic acids A (3) and B (4) were isolated from the fermentation broth of Botrytis cinerea TB-3-H8. Their structures were elucidated on the basis of MS, IR, UV, and NMR spectroscopic data. Compound 2 was isolated from natural resource for the first time. The structure of 1 was further confirmed by single-crystal X-ray diffraction (CCDC-265897).

  12. A review: trichloroethylene metabolites: potential cardiac teratogens.

    OpenAIRE

    Johnson, P. D.; Dawson, B V; Goldberg, S J

    1998-01-01

    This review is a a series of the authors' studies designed to test the hypothesis that administration of trichloroethylene (TCE), dichloroethylene (DCE), their metabolites, and related compounds are responsible for fetal cardiac teratogenesis when given to pregnant rats during organogenesis. Identification of teratogenic compounds will allow more accurate assessment of environmental contaminants and public health risks. Epidemiologic studies and previous teratogenic studies using chick embryo...

  13. [Actinomycetes from mangrove and their secondary metabolites].

    Science.gov (United States)

    Hong, Kui

    2013-11-04

    Mangroves are woody plants located in tropical and subtropical intertidal coastal regions. Driven by the discovery of novel natural products from marine environment, mangrove is becoming a hot spot for actinomycetes resources collection and secondary metabolites (natural products) identification as well as their biosynthesis mechanism investigation. Salinaspora A produced by a Salinispora strain isolated from Bahamas mangrove environment, is in the first clinical trial. Till the time of writing this paper, 24 genera of 11 families and 8 suborders under the actinomycetale have been reported from mangrove, among which 3 are new genera, and 31 are new species. At the same time, secondary metabolites were identified from the mangrove actinomycetes culture, including alkanoids and quinines, azalomycins, antimycins, bezamides and quinazolines, divergolides, indole derivatives, kandenols, macrocyclic dilactones, and the attractive structures, such as the Streptocarbazoles, the multicyclic indolsesquiterpenes, and xiamycin presented unique structures. Their biosynthetic mechanism has also been investigated. Most of the metabolites were isolated from streptomycetes, with a few from Micromonospora and Saccharopolyspora.

  14. Natural metabolites for parasitic weed management.

    Science.gov (United States)

    Vurro, Maurizio; Boari, Angela; Evidente, Antonio; Andolfi, Anna; Zermane, Nadjia

    2009-05-01

    Compounds of natural origin, such as phytotoxins produced by fungi or natural amino acids, could be used in parasitic weed management strategies by interfering with the early growth stages of the parasites. These metabolites could inhibit seed germination or germ tube elongation, so preventing attachment to the host plant, or, conversely, stimulate seed germination in the absence of the host, contributing to a reduction in the parasite seed bank. Some of the fungal metabolites assayed were very active even at very low concentrations, such as some macrocyclic trichothecenes, which at 0.1 microM strongly suppressed the germination of Orobanche ramosa L. seeds. Interesting results were also obtained with some novel toxins, such as phyllostictine A, highly active in reducing germ tube elongation and seed germination both of O. ramosa and of Cuscuta campestris Yuncker. Among the amino acids tested, methionine and arginine were particularly interesting, as they were able to suppress seed germination at concentrations lower than 1 mM. Some of the fungal metabolites tested were also able to stimulate the germination of O. ramosa seeds. The major findings in this research field are described and discussed.

  15. Phthalate Metabolites, Consumer Habits and Health Effects

    Directory of Open Access Journals (Sweden)

    Peter Wallner

    2016-07-01

    Full Text Available Phthalates are multifunctional chemicals used in a wide variety of consumer products. The aim of this study was to investigate whether levels of urinary phthalate metabolites in urine samples of Austrian mothers and their children were associated with consumer habits and health indicators. Within an Austrian biomonitoring survey, urine samples from 50 mother-child pairs of five communities (two-stage random stratified sampling were analysed. The concentrations of 14 phthalate metabolites were determined, and a questionnaire was administered. Monoethyl phthalate (MEP, mono-n-butyl phthalate (MnBP, mono-isobutyl phthalate (MiBP, monobenzyl phthalate (MBzP, mono-(2-ethylhexyl phthalate (MEHP, mono-(2-ethyl-5-hydroxyhexyl phthalate (5OH-MEHP, mono-(2-ethyl-5-oxohexyl phthalate (5oxo-MEHP, mono-(5-carboxy-2-ethylpentyl phthalate (5cx-MEPP, and 3-carboxy-mono-propyl phthalate (3cx-MPP could be quantified in the majority of samples. Significant correlations were found between the use of hair mousse, hair dye, makeup, chewing gum, polyethylene terephthalate (PET bottles and the diethyl phthalate (DEP metabolite MEP. With regard to health effects, significant associations of MEP in urine with headache, repeated coughing, diarrhoea, and hormonal problems were observed. MBzP was associated with repeated coughing and MEHP was associated with itching.

  16. Phthalate Metabolites, Consumer Habits and Health Effects

    Science.gov (United States)

    Wallner, Peter; Kundi, Michael; Hohenblum, Philipp; Scharf, Sigrid; Hutter, Hans-Peter

    2016-01-01

    Phthalates are multifunctional chemicals used in a wide variety of consumer products. The aim of this study was to investigate whether levels of urinary phthalate metabolites in urine samples of Austrian mothers and their children were associated with consumer habits and health indicators. Within an Austrian biomonitoring survey, urine samples from 50 mother-child pairs of five communities (two-stage random stratified sampling) were analysed. The concentrations of 14 phthalate metabolites were determined, and a questionnaire was administered. Monoethyl phthalate (MEP), mono-n-butyl phthalate (MnBP), mono-isobutyl phthalate (MiBP), monobenzyl phthalate (MBzP), mono-(2-ethylhexyl) phthalate (MEHP), mono-(2-ethyl-5-hydroxyhexyl) phthalate (5OH-MEHP), mono-(2-ethyl-5-oxohexyl) phthalate (5oxo-MEHP), mono-(5-carboxy-2-ethylpentyl) phthalate (5cx-MEPP), and 3-carboxy-mono-propyl phthalate (3cx-MPP) could be quantified in the majority of samples. Significant correlations were found between the use of hair mousse, hair dye, makeup, chewing gum, polyethylene terephthalate (PET) bottles and the diethyl phthalate (DEP) metabolite MEP. With regard to health effects, significant associations of MEP in urine with headache, repeated coughing, diarrhoea, and hormonal problems were observed. MBzP was associated with repeated coughing and MEHP was associated with itching. PMID:27428989

  17. Optimizing metabolite production using periodic oscillations.

    Directory of Open Access Journals (Sweden)

    Steven W Sowa

    2014-06-01

    Full Text Available Methods for improving microbial strains for metabolite production remain the subject of constant research. Traditionally, metabolic tuning has been mostly limited to knockouts or overexpression of pathway genes and regulators. In this paper, we establish a new method to control metabolism by inducing optimally tuned time-oscillations in the levels of selected clusters of enzymes, as an alternative strategy to increase the production of a desired metabolite. Using an established kinetic model of the central carbon metabolism of Escherichia coli, we formulate this concept as a dynamic optimization problem over an extended, but finite time horizon. Total production of a metabolite of interest (in this case, phosphoenolpyruvate, PEP is established as the objective function and time-varying concentrations of the cellular enzymes are used as decision variables. We observe that by varying, in an optimal fashion, levels of key enzymes in time, PEP production increases significantly compared to the unoptimized system. We demonstrate that oscillations can improve metabolic output in experimentally feasible synthetic circuits.

  18. Delta-doping in diffusion studies

    Science.gov (United States)

    Bénière, François; Chaplain, René; Gauneau, Marcel; Reddy, Viswanatha; Régrény, André

    1993-12-01

    The δ-doping where the dopant is confined on the length-scale of the lattice constant provides perfectly ideal conditions to study the atomic transport processes. We have studied MBE-grown GaAs samples δ-doped with Si and Al layers. Long time diffusion anneals have been performed in the temperature range 550 800 °C. The distribution profiles are examined by SIMS-profiling. We obtain Si diffusion coefficients in good agreement with the other recent studies using different techniques (rapid thermal annealing, capacitance-voltage profiling, sandwiched diffusion source). This contrasts with the earlier measurements based on diffusion of implanted dopants which were much more widely spread. We conclude that the more accurate data allowed with the δ-doping show that the diffusion coefficient is an intrinsic parameter provided that the amount of dopant and the dislocation density are kept sufficiently small. Le dopage-delta, où le dopant est confiné à l'échelle du paramètre du réseau, fournit les conditions parfaitement idéales pour étudier les processus de transport atomique. Nous avons étudié des échantillons de GaAs obtenus par épitaxie par jet moléculaire dopés par des couches-delta de Si et Al. Des traitements de diffusion de longue durée ont été réalisés dans l'intervalle de température 550 à 800°C. Les profils de distribution sont examinés par spectrométrie d'émission d'ions secondaires. Nous obtenons des coefficients de diffusion de Si en bon accord avec les autres études récentes utilisant des techniques différentes (traitement thermique ultrarapide, profil de distribution par la méthode capacité-voltage, diffusion d'une couche “ sandwich ”). Ceci diffère des mesures antérieures qui, basées sur la diffusion de dopants implantés, étaient beaucoup plus dispersées. Nous concluons que les données plus précises rendues possibles par le dopage-delta montrent que le coefficient de diffusion est un paramètre intrinsèque

  19. A NOTE ON DELTA-PERTURBATION EXPANSION METHOD

    Institute of Scientific and Technical Information of China (English)

    何吉欢

    2002-01-01

    The Delta-perturbation expansion method, a kind of new perturbation technique depending upon an artificial parameter Delta was studied. The study reveals that the method exits some advantages, but also exits some limitations. To overcome the limitations, the socalled linearized perturbation method proposed by HE Ji-huan can be powerfully applied.

  20. Automatisierte VHDL-Code-Generierung eines Delta-Sigma Modulators

    Science.gov (United States)

    Spilka, R.; Ostermann, T.

    2006-09-01

    Im vorliegenden Beitrag wird eine automatische Generierung des VHDL-Codes eines Delta-Sigma Modulators präsentiert. Die Koeffizientenmultiplikation wird hierbei durch Bit-Serielle-Addition durchgeführt. Mit Hilfe zweier neuer Matlab Funktionen wird der Systementwurf durch die bekannte Delta-Sigma Toolbox von R. Schreier erweitert und direkt synthesefähiger VHDL Code erzeugt.

  1. A BRITE view on delta Scuti and gamma Doradus stars

    CERN Document Server

    Zwintz, Konstanze

    2016-01-01

    BRITE-Constellation has obtained data for a few delta Scuti and gamma Doradus type stars. A short overview of the pulsational content found in five stars - beta Cassiopeiae, epsilon Cephei, M Velorum, beta Pictoris and QW Puppis - is given and the potential of BRITE-Constellation observations of delta Scuti and gamma Doradus pulsators is discussed.

  2. Terahertz radiation from delta-doped GaAs

    DEFF Research Database (Denmark)

    Birkedal, Dan; Hansen, Ole; Sørensen, Claus Birger;

    1994-01-01

    Terahertz pulse emission from four different delta-doped molecular beam epitaxially grown GaAs samples is studied. We observe a decrease of the emitted THz pulse amplitude as the distance of the delta-doped layer from the surface is increased, and a change in polarity of the THz pulses as compared...

  3. Women in Leadership Roles in Phi Delta Kappa.

    Science.gov (United States)

    Harder, Martha B.; And Others

    The professional and personal characteristics of the men and women in Phi Delta Kappa who hold the top elected positions in local chapters were compared, and the perceptions of these leaders of the impact of allowing women to be members of Phi Delta Kappa were assessed. A 43-item questionnaire was developed and mailed to 1,340 chapter presidents…

  4. Downstream hydraulic geometry of a tidally influenced river delta

    NARCIS (Netherlands)

    Sassi, M.G.; Hoitink, A.J.F.; Brye, de B.; Deleersnijder, E.

    2012-01-01

    Channel geometry in tidally influenced river deltas can show a mixed scaling behavior between that of river and tidal channel networks, as the channel forming discharge is both of river and tidal origin. We present a method of analysis to quantify the tidal signature on delta morphology, by extendin

  5. Towards a Comprehensive Framework for Adaptive Delta Management

    NARCIS (Netherlands)

    Marchand, M.; Ludwig, F.

    2014-01-01

    Deltas are dynamic landforms at the boundary of land and sea, involving intricate mazes of rivers and small waterways, wetlands, estuaries and coastal barrier islands. They are home to over half a billion people. Deltas are also home to rich ecosystems, such as mangroves and marshes. They are

  6. Delta's paradise: a challenge for lan[d]scape architects

    NARCIS (Netherlands)

    Boekhorst, te J.K.M.; Toorn, van den M.W.M.

    1996-01-01

    Paradise as a metaphor has always played an important role in art. This is definitely true for the art of garden design, but paradise is also a metaphor that can be used for the landscape. Some of the most interesting landscapes are found in deltas. Deltas are rich in natural and economic potential.

  7. Towards a Comprehensive Framework for Adaptive Delta Management

    NARCIS (Netherlands)

    Marchand, M.; Ludwig, F.

    2014-01-01

    Deltas are dynamic landforms at the boundary of land and sea, involving intricate mazes of rivers and small waterways, wetlands, estuaries and coastal barrier islands. They are home to over half a billion people. Deltas are also home to rich ecosystems, such as mangroves and marshes. They are econom

  8. An annotated list of Fishes from the Niger Delta

    NARCIS (Netherlands)

    Boeseman, M.

    1963-01-01

    At the end of November 1960, the Leiden Museum received an interesting collection of animals, mostly fishes, from the Niger delta. All specimens were collected by Mr. H. J. G. Beets, at the time employed by Shell B.P. — Delta Investigations, during the period May to August 1960, and in the region

  9. Delta's paradise: a challenge for lan[d]scape architects

    NARCIS (Netherlands)

    te Boekhorst, J.K.M.; Toorn, van den M.W.M.

    1996-01-01

    Paradise as a metaphor has always played an important role in art. This is definitely true for the art of garden design, but paradise is also a metaphor that can be used for the landscape. Some of the most interesting landscapes are found in deltas. Deltas are rich in natural and economic potential.

  10. Emerging leadership from communities in the Lower Mississippi Delta (LMD)

    Science.gov (United States)

    The Delta NIRI (Nutrition Intervention Research Initiative) team has conducted several research studies in the Lower Mississippi Delta (LMD) region employing the community-based participatory research (CBPR) model. Our collaborative work in the LMD focuses on interventions conducted in each of our c...

  11. Spatio-temporal distributions of delta18O, delta D and salinity in the Arabian Sea: Identifying processes and controls

    Digital Repository Service at National Institute of Oceanography (India)

    Deshpande, R.D.; Muraleedharan, P.M.; Singh, R.L.; Kumar, B.; Rao, M.S.; Dave, M.; Sivakumar, K.U.; Gupta, S.K.

    of these parameters. From the distributions of delta18O and salinity (S), and the relationships between delta18OdeltaD and delta18O–S, the following inferences have been drawn: (1) there is a broad correspondence between...

  12. 78 FR 21491 - DeltaPoint Capital IV, L.P., DeltaPoint Capital IV (New York), L.P.; Notice Seeking Exemption...

    Science.gov (United States)

    2013-04-10

    ... ADMINISTRATION DeltaPoint Capital IV, L.P., DeltaPoint Capital IV (New York), L.P.; Notice Seeking Exemption Under Section 312 of the Small Business Investment Act, Conflicts of Interest Notice is hereby given that DeltaPoint Capital IV, L.P. and DeltaPoint Capital IV (New York), L.P., 45 East Avenue, 6th...

  13. The Concentration Dependence of the (Delta)s Term in the Gibbs Free Energy Function: Application to Reversible Reactions in Biochemistry

    Science.gov (United States)

    Gary, Ronald K.

    2004-01-01

    The concentration dependence of (delta)S term in the Gibbs free energy function is described in relation to its application to reversible reactions in biochemistry. An intuitive and non-mathematical argument for the concentration dependence of the (delta)S term in the Gibbs free energy equation is derived and the applicability of the equation to…

  14. Metabolic origin of the {delta}{sup 13}C of respired CO{sub 2} in roots of Phaseolus vulgaris

    Energy Technology Data Exchange (ETDEWEB)

    Bathellier, C.; Tcherkez, G.; Cornic, G.; Ghashghaie, J. [Laboratoire d' Ecologie, Systematique et Evolution - ESE, CNRS-UMR 8079 - IFR 87, Batiment 362, Universite Paris-Sud, 91405-Orsay Cedex (France); Tcherkez, G. [Plateforme Metabolisme-Metabolome, IFR87 La Plante et son Environnement, Institut de Biotechnologie des Plantes, Batiment 630, Universite Paris-Sud, 91405-Orsay Cedex (France); Bligny, R.; Gout, E. [Laboratoire de Physiologie Cellulaire Vegetale CEA-Grenoble 17, rue des Martyrs, 38054 Grenoble Cedex 9 (France)

    2009-07-01

    - Root respiration is a major contributor to soil CO{sub 2} efflux, and thus an important component of ecosystem respiration. But its metabolic origin, in relation to the carbon isotope composition ({delta}{sup 13}C), remains poorly understood. - Here, {sup 13}C analysis was conducted on CO{sub 2} and metabolites under typical conditions or under continuous darkness in French bean (Phaseolus vulgaris) roots. {sup 13}C contents were measured either under natural abundance or following pulse-chase labeling with {sup 13}C-enriched glucose or pyruvate, using isotope ratio mass spectrometer (IRMS) and nuclear magnetic resonance (NMR) techniques. - In contrast to leaves, no relationship was found between the respiratory quotient and the {delta}{sup 13}C of respired CO{sub 2}, which stayed constant at a low value (c. -27.5 per thousand) under continuous darkness. With labeling experiments, it is shown that such a pattern is explained by the {sup 13}C-depleting effect of the pentose phosphate pathway; and the involvement of the Krebs cycle fueled by either the glycolytic input or the lipid/protein recycling. The anaplerotic phosphoenolpyruvate carboxylase (PEPc) activity sustained glutamic acid (Glu) synthesis, with no net effect on respired CO{sub 2}. - These results indicate that the root {delta}{sup 13}C signal does not depend on the availability of root respiratory substrates and it is thus plausible that, unless the {sup 13}C photosynthetic fractionation varies at the leaf level, the root {delta}{sup 13}C signal hardly changes under a range of natural environmental conditions. (authors)

  15. Surface Delta Interaction and g factors

    CERN Document Server

    Yu, Xiaofei

    2015-01-01

    Using an attractive surface delta interaction we obtain wave functions for 2 neutrons (or neutron holes) in the model space of 2 orbits (l=4, j=7/2) and (l=2, j=5/2). If we take the single particle energies to be degenerate we find that the g factors for I=2, 4 and 6 are all the same -namely the orbital g factor of the single nucleon. For a free neutron this quantity zero all 2particle or 2 hole g factors are equal to zero as well.. Only the orbital part of the g -factors contribute - the spin part cancels out. We then consider the effects of introducing a single energy splititng between the 2 orbits.

  16. Historical floods in the Dutch Rhine Delta

    Directory of Open Access Journals (Sweden)

    R. Glaser

    2003-01-01

    Full Text Available Historical records provide direct information about the climatic impact on society. Especially great natural disasters such as river floods have been for long attracting the attention of humankind. Time series for flood development on the Rhine branches Waal, Nederrijn/Lek and IJssel in the Dutch Rhine Delta are presented in this paper. In the case of the Waal it is even possible to compare historical flood frequencies based on documentary data with the recent development reconstructed from standardized instrumental measurements. In brief, we will also discuss various parameters concerning the structure of the flood series and the "human dimension" of natural disaster, i.e. the vulnerability of society when facing natural disasters.

  17. Head orientation prediction: delta quaternions versus quaternions.

    Science.gov (United States)

    Himberg, Henry; Motai, Yuichi

    2009-12-01

    Display lag in simulation environments with helmet-mounted displays causes a loss of immersion that degrades the value of virtual/augmented reality training simulators. Simulators use predictive tracking to compensate for display lag, preparing display updates based on the anticipated head motion. This paper proposes a new method for predicting head orientation using a delta quaternion (DQ)-based extended Kalman filter (EKF) and compares the performance to a quaternion EKF. The proposed framework operates on the change in quaternion between consecutive data frames (the DQ), which avoids the heavy computational burden of the quaternion motion equation. Head velocity is estimated from the DQ by an EKF and then used to predict future head orientation. We have tested the new framework with captured head motion data and compared it with the computationally expensive quaternion filter. Experimental results indicate that the proposed DQ method provides the accuracy of the quaternion method without the heavy computational burden.

  18. Spectral factorization using the delta operator

    DEFF Research Database (Denmark)

    Rostgaard, Morten; Poulsen, Niels Kjølstad; Ravn, Ole

    1994-01-01

    In recent years many papers have been published abouth the gamma-operator, mostly caused by the better numerical properties and the rapprochement between continuous and discrete time. A major problem within the LQG-design of a delta-based input-output relation has been how to spectral......-factorize in an efficient way. The discrete-time method of Kuccera will not be applied since numerical word-length characteristics will be poor for fast sampling rates. In this paper a new approach is considered. A new gamma-operator (Tustin operator) is introduced, in order to make an iterative and numerical stable...... solution to the spectral factorization problem. The key idea is to use the gamma-operator resembled by its behavior to the differential operator....

  19. Delta-excitations and the three-nucleon force

    CERN Document Server

    Epelbaum, E; Meißner, Ulf-G

    2007-01-01

    We study the three-nucleon force in chiral effective field theory with explicit Delta-resonance degrees of freedom. We show that up to next-to-next-to-leading order, the only contribution to the isospin symmetric three-nucleon force involving the spin-3/2 degrees of freedom is given by the two-pion-exchange diagram with an intermediate delta, frequently called the Fujita-Miyazawa force. We also analyze the leading isospin-breaking corrections due to the delta. For that, we give the first analysis of the delta quartet mass splittings in chiral effective field theory. The charge-symmetry breaking three-nucleon force due to an intermediate delta excitation is small, of the order of a few keV.

  20. Automatic Detection of Magnetic delta in Sunspot Groups

    CERN Document Server

    Padinhatteeri, Sreejith; Bloomfield, D Shaun; Gallagher, Peter T

    2015-01-01

    Large and magnetically complex sunspot groups are known to be associated with flares. To date, the Mount Wilson scheme has been used to classify sunspot groups based on their morphological and magnetic properties. The most flare prolific class, the delta sunspot-group, is characterised by opposite polarity umbrae within a common penumbra, separated by less than 2 degrees. In this article, we present a new system, called the Solar Monitor Active Region Tracker - Delta Finder (SMART-DF), that can be used to automatically detect and classify magnetic deltas in near-realtime. Using continuum images and magnetograms from the Helioseismic and Magnetic Imager (HMI) onboard NASA's Solar Dynamics Observatory (SDO), we first estimate distances between opposite polarity umbrae. Opposite polarity pairs having distances of less that 2 degrees are then identified, and if these pairs are found to share a common penumbra, they are identified as a magnetic delta configuration. The algorithm was compared to manual delta detect...

  1. Effects of isovector scalar $\\delta$-meson on hypernuclei

    CERN Document Server

    Ikram, M; Biswal, S K; Patra, S K

    2014-01-01

    We analyze the effects of $\\delta-$ meson on hypernuclei within the frame-work of relativistic mean field theory. The $\\delta-$ meson is included into the Lagrangian for hypernuclei. The extra nucleon-meson coupling ($g_\\delta$) affects the every piece of physical observables, like binding energy, radii and single particle energy of hypernuclei. The lambda mean field potential is investigated which is consistent with other predictions. Flipping of single particle energy levels are observed with the strength of $g_\\delta$ in the considered hypernuclei as well as normal nuclei. The spin-orbit potentials are observed for considered hypernuclei and the effect of $g_\\delta$ on spin-orbit potentials is also analyzed. The calculated single-$\\Lambda$ binding energies ($B_\\Lambda$) are quite agreeable with the experimental data.

  2. Isolation of Delta9-THCA-A from hemp and analytical aspects concerning the determination of Delta9-THC in cannabis products.

    Science.gov (United States)

    Dussy, Franz E; Hamberg, Cornelia; Luginbühl, Marco; Schwerzmann, Thomas; Briellmann, Thomas A

    2005-04-20

    A simple procedure based on a common silica gel column chromatography for the isolation of Delta9-tetrahydrocannabinolic acid A (Delta9-THCA-A) from hemp in a multi-milligram scale is presented. Further, the decarboxylation reaction of Delta9-THCA-A to the toxicologically active Delta9-tetrahydrocannabinol (Delta9-THC) at different analytical and under-smoking conditions is investigated. Maximal conversion in an optimised analytical equipment yields about 70% Delta9-THC. In the simulation of the smoking process, only about 30 % of the spiked substance could be recovered as Delta9-THC.

  3. Multimode delta-E effect magnetic field sensors with adapted electrodes

    Energy Technology Data Exchange (ETDEWEB)

    Zabel, Sebastian; Fichtner, Simon; Kirchhof, Christine; Quandt, Eckhard; Faupel, Franz, E-mail: ff@tf.uni-kiel.de [Faculty of Engineering, Institute for Materials Science, Kiel University, Kaiserstraße 2, 24143 Kiel (Germany); Reermann, Jens; Schmidt, Gerhard [Faculty of Engineering, Institute for Electrical Engineering, Kiel University, Kaiserstraße 2, 24143 Kiel (Germany); Wagner, Bernhard [Fraunhofer Institute for Silicon Technology ISIT, Fraunhoferstraße 1, 25524 Itzehoe (Germany)

    2016-05-30

    We present an analytical and experimental study on low-noise piezoelectric thin film resonators that utilize the delta-E effect of a magnetostrictive layer to measure magnetic fields at low frequencies. Calculations from a physical model of the electromechanical resonator enable electrode designs to efficiently operate in the first and second transversal bending modes. As predicted by our calculations, the adapted electrode design improves the sensitivity by a factor of 6 and reduces the dynamic range of the sensor output by 16 dB, which significantly eases the requirements on readout electronics. Magnetic measurements show a bandwidth of 100 Hz at a noise level of about 100 pTHz{sup −0.5}.

  4. Multimode delta-E effect magnetic field sensors with adapted electrodes

    Science.gov (United States)

    Zabel, Sebastian; Reermann, Jens; Fichtner, Simon; Kirchhof, Christine; Quandt, Eckhard; Wagner, Bernhard; Schmidt, Gerhard; Faupel, Franz

    2016-05-01

    We present an analytical and experimental study on low-noise piezoelectric thin film resonators that utilize the delta-E effect of a magnetostrictive layer to measure magnetic fields at low frequencies. Calculations from a physical model of the electromechanical resonator enable electrode designs to efficiently operate in the first and second transversal bending modes. As predicted by our calculations, the adapted electrode design improves the sensitivity by a factor of 6 and reduces the dynamic range of the sensor output by 16 dB, which significantly eases the requirements on readout electronics. Magnetic measurements show a bandwidth of 100 Hz at a noise level of about 100 pTHz-0.5.

  5. Dependence of {delta}E effect on internal stresses in nickel: Experimental results by laser interferometry

    Energy Technology Data Exchange (ETDEWEB)

    Chicharro, J.M. [Dept. de Mecanica Aplicada e Ingenieria de Proyectos, E.T.S.I. Industriales, Universidad de Castilla-La Mancha, Avd. Camilo Jose Cela s/n, 13071 Ciudad Real (Spain)]. E-mail: josemanuel.chicharro@uclm.es; Bayon, A. [Dept. de Fisica Aplicada a los Recursos Naturales, E.T.S.I. Minas, Universidad Politecnica de Madrid, c/Rios Rosas, 21, 28003 Madrid (Spain); Salazar, F. [Dept. de Fisica Aplicada a los Recursos Naturales, E.T.S.I. Minas, Universidad Politecnica de Madrid, c/Rios Rosas, 21, 28003 Madrid (Spain)

    2006-02-15

    The speckle heterodyne interferometry is applied to the study of the dependence of Young's modulus on both the magnetic field and the internal stresses in a soft ferromagnetic material. Young's modulus is determined from the first natural longitudinal frequency of a slender magnetic rod positioned within a solenoid. Vibration of the sample is detected by an optical heterodyne system with a wide bandwidth. The samples are heated to above the Curie point and then cooled at several rates in order to induce different internal stresses. The study refers to nickel rods 10mm in diameter and 110mm in length. The grain sizes of the samples are also determined and related to changes in {delta}E.

  6. Extensive junctional diversity of rearranged human T cell receptor delta genes.

    Science.gov (United States)

    Hata, S; Satyanarayana, K; Devlin, P; Band, H; McLean, J; Strominger, J L; Brenner, M B; Krangel, M S

    1988-06-10

    The human T cell receptor delta (TCR delta) gene encodes one component of the TCR gamma delta-CD3 complex found on subsets of peripheral blood and thymic T cells. Human TCR delta diversity was estimated by characterizing rearrangements in TCR gamma delta cell lines and determining the structures of complementary DNA clones representing functional and nonfunctional transcripts in these cell lines. One V delta segment and one J delta segment were identified in all functional transcripts, although a distinct J delta segment was identified in a truncated transcript. Further, one D delta element was identified, and evidence for the use of an additional D delta element was obtained. Thus human TCR delta genes appear to use a limited number of germline elements. However, the apparent use of two D delta elements in tandem coupled with imprecise joining and extensive incorporation of N nucleotides generates unprecedented variability in the junctional region.

  7. Potency of Mahakam Delta in East Kalimantan, Indonesia

    Directory of Open Access Journals (Sweden)

    Zairin Zain

    2014-04-01

    Full Text Available Normal 0 false false false IN X-NONE X-NONE Mahakam Delta is not only utilized for fishery activities but also for several industrial purposes such as coal and oil mining, shipping and timber. The objective of this paper is to provide information in term of the potency of Mahakam Delta located in East Kalimantan province, Indonesia. The study was conducted in Mahakam Delta, East Kalimantan Province, Indonesia. Participatory rural appraisal is a group of methods to collect information in a participatory fashion from rural communities. The method employed in this research was descriptive analysis describing the environmental potency found in Mahakam Delta. Massive conversion of mangrove forest particularly Nypa (Nypa fruticans area into pond has driven conflict among related stakeholders on the utilization of natural resource and land which subsequently impacts on the fish and shrimp source regeneration, loss of ecological functions of mangrove forest for feeding, nursery and spawning ground of fish and other organisms. Besides of fisheries, oil and gas activity also exists in Mahakam Delta. Mahakam Delta is regarded as important area due to the largest producer of oil and gas mining. Thus, oil and gas industry is the most reliable sector that contributes to the economic development of Kutai Kartanegara district. As a resource provider, Mahakam Delta ecosystem provides various resources for livelihoods. As a life-support service provider, Mahakam Delta ecosystem provides habitat and ideal environment to support variety of living kinds. As a convenience provider, Mahakam Delta ecosystem provides unique and interesting recreation site. As a protector from natural disaster, Mahakam Delta ecosystem is able to protect human kinds from natural disaster threatening coastal area.

  8. Sustainable Growth in Urbanised Delta Areas: the Opportunities of a Geographical Approach to the Pearl River Delta

    NARCIS (Netherlands)

    Van Rens, G.; Nillisen, A.L.; Schamhart, C.; Lugt, N.

    2006-01-01

    The attractions of delta areas have boomed economies and founded major cities, but the threats of the adjacent water have persisted and natural resources have declined. The objective to facilitate sustainable urban growth in delta areas can only be met by a simultaneous approach of all the stakehold

  9. Preservation potential of the Last Interglacial lower Rhine delta relative to the Holocene Rhine-Meuse delta

    NARCIS (Netherlands)

    Peeters, J.; Martinius, A.W.; Cohen, K.M.; Middelkoop, H.; Stouthamer, E.

    2013-01-01

    In order to improve our insights in the sequence stratigraphic and architectural development of lower deltaic hydrocarbon reservoirs we study the Last Interglacial Rhine delta (MIS-5), and compare it to its well investigated counterpart, the Holocene (MIS-1) Rhine- Meuse delta (Berendsen & Stouthame

  10. Regulatory Roles of Metabolites in Cell Signaling Networks

    Institute of Scientific and Technical Information of China (English)

    Feng Li; Wei Xu; Shimin Zhao

    2013-01-01

    Mounting evidence suggests that cellular metabolites,in addition to being sources of fuel and macromolecular substrates,are actively involved in signaling and epigenetic regulation.Many metabolites,such as cyclic AMP,which regulates phosphorylation/dephosphorylation,have been identified to modulate DNA and histone methylation and protein stability.Metabolite-driven cellular regulation occurs through two distinct mechanisms:proteins allosterically bind or serve as substrates for protein signaling pathways,and metabolites covalently modify proteins to regulate their functions.Such novel protein metabolites include fumarate,succinyl-CoA,propionyl-CoA,butyryl-CoA and crontonyl-CoA.Other metabolites,including α-ketoglutarate,succinate and fumarate,regulate epigenetic processes and cell signaling via protein binding.Here,we summarize recent progress in metabolite-derived post-translational protein modification and metabolite-binding associated signaling regulation.Uncovering metabolites upstream of cell signaling and epigenetic networks permits the linkage of metabolic disorders and human diseases,and suggests that metabolite modulation may be a strategy for innovative therapeutics and disease prevention techniques.

  11. Endogenous cross-talk of fungal metabolites.

    Directory of Open Access Journals (Sweden)

    Kevin J Sheridan

    2015-01-01

    Full Text Available Non-ribosomal peptide synthesis in fungi requires a ready supply of proteogenic and non-proteogenic amino acids which are subsequently incorporated into the nascent non-ribosomal peptide via a thiotemplate mechanism catalysed by non-ribosomal peptide synthetases. Substrate amino acids can be modified prior to or during incorporation into the non-ribosomal peptide, or following incorporation into an early stage amino acid-containing biosynthetic intermediate. These post-incorporation modifications involve a range of additional enzymatic activities including but not exclusively, monooxygenases, methyltransferases, epimerases, oxidoreductases and glutathione transferases which are essential to effect biosynthesis of the final non-ribosomal peptide. Likewise, polyketide biosynthesis is directly by polyketide synthase megaenzymes and cluster-encoded ancilliary decorating enzymes. Additionally, a suite of additional primary metabolites, for example: CoA, acetyl CoA, S-adenosylmethionine, glutathione, NADPH, malonyl CoA and molecular oxygen, amongst others are required for non-ribosomal peptide and polyketide synthesis. Clearly these processes must involve exquisite orchestration to facilitate the simultaneous biosynthesis of different types of non-ribosomal peptides, polyketides, and related metabolites requiring identical or similar biosynthetic precursors or co-factors. Moreover, the near identical structures of many natural products within a given family (e.g., ergot alkaloids, along with localization to similar regions within fungi (e.g., conidia suggests that cross-talk may exist, in terms of biosynthesis and functionality. Finally, we speculate if certain biosynthetic steps involved in non-ribosomal peptide and polyketide synthesis play a role in cellular protection or environmental adaptation, and wonder if these enzymatic reactions are of equivalent importance to the actual biosynthesis of the final metabolite.

  12. Marine metabolites: The sterols of soft coral

    Digital Repository Service at National Institute of Oceanography (India)

    Sarma, N.S.; Krishna, M.S.; Pasha, Sk.G.; Rao, T.S.P.; Venkateswarlu, Y.; Parameswaran, P.S.

    stream_size 141933 stream_content_type text/plain stream_name Chem_Rev_109_2803.pdf.txt stream_source_info Chem_Rev_109_2803.pdf.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 Marine Metabolites... nuclear structure or of the “usual” C 8 or C 9 side chain. The side chains of corals can have from nil to eleven carbons. Their structures are given in Figures 1-5inthe sequence of increasing number of carbon atomsstwo, three, four, five, and seven carbon...

  13. New Secondary Metabolites from Quercus coccifera L.

    Directory of Open Access Journals (Sweden)

    Didem Şöhretoğlu

    2014-07-01

    Full Text Available Three new secondary metabolites kermesoside (1, cocciferoside (2 and (--8-chlorocatechin (3, were isolated from the the stems with barks of Quercus coccifera along with five known phenolic compounds, 3-hydroxy-1-(4-hydroxy-3-methoxyphenyl-propan-1-one (4 and 3-hydroxy-1-(4-hydroxy-3,5-dimethoxyphenyl-propan-1-one (5, trans-resveratrol-3-O-β-glucopyranoside (6 lyoniresinol-9-O-β-xylopyranoside (7, lyoniresinol-9-O-β-glucopyranoside (8. The structure elucidation of the isolated compounds was performed by spectroscopic methods (UV, 1D- and 2D- NMR and HR-MS.

  14. The fluvial evolution of the Holocene Nile Delta

    Science.gov (United States)

    Pennington, B. T.; Sturt, F.; Wilson, P.; Rowland, J.; Brown, A. G.

    2017-08-01

    The evolution of the Nile Delta, the largest delta system in the Mediterranean Sea, has both high palaeoenvironmental and archaeological significance. A dynamic model of the landscape evolution of this delta system is presented for the period c.8000-4500 cal BP. Analysis of sedimentary data and chronostratigraphic information contained within 1640 borehole records has allowed for a redefinition of the internal stratigraphy of the Holocene delta, and the construction of a four-dimensional landscape model for the delta's evolution through time. The mid-Holocene environmental evolution is characterised by a transition from an earlier set of spatially varied landscapes dominated by swampy marshland, to better-drained, more uniform floodplain environments. Archaeologically important Pleistocene inliers in the form of sandy hills protruding above the delta plain surface (known as ;turtlebacks;), also became smaller as the delta plain continued to aggrade, while the shoreline and coastal zone prograded north. These changes were forced by a decrease in the rate of relative sea-level rise under high rates of sediment-supply. This dynamic environmental evolution needs to be integrated within any discussion of the contemporary developments in the social sphere, which culminated in the emergence of the Ancient Egyptian State c.5050 cal BP.

  15. Hot deformation behavior of delta-processed superalloy 718

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Y., E-mail: wangyanhit@yahoo.cn [State Key Laboratory of Powder Metallurgy, Central South University, Changsha 410083 (China); School of Aeronautics and Astronautics, Central South University, Changsha 410083 (China); Shao, W.Z.; Zhen, L.; Zhang, B.Y. [School of Materials Science and Engineering, Harbin Institute of Technology, Harbin 150001 (China)

    2011-03-25

    Research highlights: {yields} The peak stress for hot deformation can be described by the Z parameter. {yields} The grain size of DRX was inversely proportional to the Z parameter. {yields} The dissolution of {delta} phases was greatly accelerated under hot deformation. {yields}The {delta} phase stimulated nucleation can serve as the main DRX mechanism. - Abstract: Flow stress behavior and microstructures during hot compression of delta-processed superalloy 718 at temperatures from 950 to 1100 deg. C with strain rates of 10{sup -3} to 1 s{sup -1} were investigated by optical microscopy (OM), electron backscatter diffraction (EBSD) technique and transmission electron microscopy (TEM). The relationship between the peak stress and the deformation conditions can be expressed by a hyperbolic-sine type equation. The activation energy for the delta-processed superalloy 718 is determined to be 467 kJ/mol. The change of the dominant deformation mechanisms leads to the decrease of stress exponent and the increase of activation energy with increasing temperature. The dynamically recrystallized grain size is inversely proportional to the Zener-Hollomon (Z) parameter. It is found that the dissolution rate of {delta} phases under hot deformation conditions is much faster than that under static conditions. Dislocation, vacancy and curvature play important roles in the dissolution of {delta} phases. The main nucleation mechanisms of dynamic recrystallization (DRX) for the delta-processed superalloy 718 include the bulging of original grain boundaries and the {delta} phase stimulated DRX nucleation, which is closely related to the dissolution behavior of {delta} phases under certain deformation conditions.

  16. Primary production in the Delta: Then and now

    Science.gov (United States)

    Cloern, James E.; Robinson, April; Richey, Amy; Grenier, Letitia; Grossinger, Robin; Boyer, Katharyn E.; Burau, Jon; Canuel, Elizabeth A.; DeGeorge, John F.; Drexler, Judith Z.; Enright, Chris; Howe, Emily R.; Kneib, Ronald; Mueller-Solger, Anke; Naiman, Robert J.; Pinckney, James L.; Safran, Samuel M.; Schoellhamer, David H.; Simenstad, Charles A.

    2016-01-01

    To evaluate the role of restoration in the recovery of the Delta ecosystem, we need to have clear targets and performance measures that directly assess ecosystem function. Primary production is a crucial ecosystem process, which directly limits the quality and quantity of food available for secondary consumers such as invertebrates and fish. The Delta has a low rate of primary production, but it is unclear whether this was always the case. Recent analyses from the Historical Ecology Team and Delta Landscapes Project provide quantitative comparisons of the areal extent of 14 habitat types in the modern Delta versus the historical Delta (pre-1850). Here we describe an approach for using these metrics of land use change to: (1) produce the first quantitative estimates of how Delta primary production and the relative contributions from five different producer groups have been altered by large-scale drainage and conversion to agriculture; (2) convert these production estimates into a common currency so the contributions of each producer group reflect their food quality and efficiency of transfer to consumers; and (3) use simple models to discover how tidal exchange between marshes and open water influences primary production and its consumption. Application of this approach could inform Delta management in two ways. First, it would provide a quantitative estimate of how large-scale conversion to agriculture has altered the Delta's capacity to produce food for native biota. Second, it would provide restoration practitioners with a new approach—based on ecosystem function—to evaluate the success of restoration projects and gauge the trajectory of ecological recovery in the Delta region.

  17. Using Hairy Roots for Production of Valuable Plant Secondary Metabolites.

    Science.gov (United States)

    Tian, Li

    2015-01-01

    Plants synthesize a wide variety of natural products, which are traditionally termed secondary metabolites and, more recently, coined specialized metabolites. While these chemical compounds are employed by plants for interactions with their environment, humans have long since explored and exploited plant secondary metabolites for medicinal and practical uses. Due to the tissue-specific and low-abundance accumulation of these metabolites, alternative means of production in systems other than intact plants are sought after. To this end, hairy root culture presents an excellent platform for producing valuable secondary metabolites. This chapter will focus on several major groups of secondary metabolites that are manufactured by hairy roots established from different plant species. Additionally, the methods for preservations of hairy roots will also be reviewed.

  18. Holocene evolution of the western Orinoco Delta, Venezuela

    Science.gov (United States)

    Aslan, A.; White, W.A.; Warne, A.G.; Guevara, E.H.

    2003-01-01

    The pristine nature of the Orinoco Delta of eastern Venezuela provides unique opportunities to study the geologic processes and environments of a major tropical delta. Remote-sensing images, shallow cores, and radiocarbon-dating of organic remains form the basis for describing deltaic environments and interpreting the Holocene history of the delta. The Orinoco Delta can be subdivided into two major sectors. The southeast sector is dominated by the Rio Grande-the principal distributary-and complex networks of anastomosing fluvial and tidal channels. The abundance of siliciclastic deposits suggests that fluvial processes such as over-bank flooding strongly influence this part of the delta. In contrast, the northwest sector is represented by few major distributaries, and overbank sedimentation is less widespread relative to the southeast sector. Peat is abundant and occurs in herbaceous and forested swamps that are individually up to 200 km2 in area. Northwest-directed littoral currents transport large volumes of suspended sediment and produce prominent mudcapes along the northwest coast. Mapping of surface sediments, vegetation, and major landforms identified four principal geomorphic systems within the western delta plain: (1) distributary channels, (2) interdistributary flood basins, (3) fluvial-marine transitional environments, and (4) marine-influenced coastal environments. Coring and radiocarbon dating of deltaic deposits show that the northern delta shoreline has prograded 20-30 km during the late Holocene sea-level highstand. Progradation has been accomplished by a combination of distributary avulsion and mudcape progradation. This style of deltaic progradation differs markedly from other deltas such as the Mississippi where distributary avulsion leads to coastal land loss, rather than shoreline progradation. The key difference is that the Orinoco Delta coastal zone receives prodigious amounts of sediment from northwest-moving littoral currents that transport

  19. Regional pole assignment for uncertain delta-operator systems

    Institute of Scientific and Technical Information of China (English)

    Man LIU; Yuanwei JING; Siying ZHANG

    2004-01-01

    The pole assignment in a specified disk by state feedback for uncertain delta-operator systems is studied.By making use of algebra Riccati equations,a sufficient and necessary condition of pole assignment for a kind of parameter uncertain delta-operator system in a specified disk by state feedback is presented.And the design method of state feedback controller is also developed.The proposed method can unify some previous related results of continuous and discrete time systems into the delta framework.The efficiency of the design method is illustrated by a numerical example.

  20. Electromagnetic form factors of the Delta with D-waves

    CERN Document Server

    Ramalho, G; Gross, Franz

    2010-01-01

    The electromagnetic form factors of the Delta baryon are evaluated within the framework of a covariant spectator quark model, where S and D-states are included in the $\\Delta$ wave function. We predict all the four Delta multipole form factors: the electric charge GE0, the magnetic dipole GM1, the electric quadrupole GE2 and the magnetic octupole GM3. We compare our predictions with other theoretical calculations. Our results are compatible with the available experimental data and recent lattice QCD data.

  1. Late quaternary evolution of the Orinoco Delta, Venezuela

    Science.gov (United States)

    Warne, A.G.; Guevara, E.H.; Aslan, A.

    2002-01-01

    The modern Orinoco Delta is the latest of a series of stacked deltas that have infilled the Eastern Venezuelan Basin (EVB) since the Oligocene. During the late Pleistocene sea-level lowstand (20,000 to 16,000 yrs BP), bedrock control points at the position of the present delta apex prevented the river channel from incising as deeply as many other major river systems. Shallow seismic data indicate that the late Pleistocene Orinoco incised into the present continental shelf, where it formed a braided-river complex that transported sediment to a series of shelf-edge deltas. As sea level rose from 16,000 to 9,500 yrs BP, the Orinoco shoreline shifted rapidly landward, causing shallow-marine waves and currents to form a widespread transgressive sand unit. Decelerating sea-level rise and a warmer, wetter climate during the early Holocene (9,500 to 6,000 yrs BP) induced delta development within the relatively quiet-water environment of the EVB embayment. Sea level approached its present stand in the middle Holocene (6,000 to 3,000 yrs BP), and the Orinoco coast prograded, broadening the delta plain and infilling the EVB embayment. Significant quantities of Amazon sediment began to be transported to the Orinoco coast by littoral currents. Continued progradation in the late Holocene caused the constriction at Boca de Serpientes to alter nearshore and shelf hydrodynamics and subdivide the submarine delta into two distinct areas: the Atlantic shelf and the Gulf of Paria. The increased influence of littoral currents along the coast promoted mudcape development. Because most of the water and sediment were transported across the delta plain through the Rio Grande distributary in the southern delta, much of the central and northwestern delta plain became sediment starved, promoting widespread accumulation of peat deposits. Human impacts on the delta are mostly associated with the Volca??n Dam on Can??o Manamo. However, human activities have had relatively little effect on the

  2. On generalized {delta}-semiclosed sets in topological spaces

    Energy Technology Data Exchange (ETDEWEB)

    Park, Jin Han [Division of Mathematical Sciences, Pukyong National University, Pusan 608-737 (Korea, Republic of)]. E-mail: jihpark@pknu.ac.kr; Song, Dae Seob [Division of Mathematical Sciences, Pukyong National University, Pusan 608-737 (Korea, Republic of); Saadati, Reza [Department of Mathematics, and Computer Science, Amirkabir University of Technology, 424 Hafez Avenue, Tehran 15914 (Iran, Islamic Republic of) and Department of Mathematics, Amol Islamic Azad University, Amol 46176-54553 (Iran, Islamic Republic of)]. E-mail: rsaadati@eml.cc

    2007-08-15

    The aim of this paper is to introduce the class of g{delta}s-closed sets and obtain the characterizations of T {sub 3/4} space due to Dontchev and Ganster [Dontchev J, Ganster M. On {delta}-generalized closed set and T {sub 3/4}-spaces. Mem Fac Sci Kochi Univ Ser A (Math) 1996;17:15-31]. We also introduce the notion of g{delta}s-continuity and investigate the relationships between it and other types of continuity.

  3. Is there a self-organization principle of river deltas?

    Science.gov (United States)

    Tejedor, Alejandro; Longjas, Anthony; Foufoula-Georgiou, Efi

    2017-04-01

    River deltas are known to possess a complex topological and flux-partitioning structure which has recently been quantified using spectral graph theory [Tejedor et al., 2015a,b]. By analysis of real and simulated deltas it has also been shown that there is promise in formalizing relationships between this topo-dynamic delta structure and the underlying delta forming processes [e.g., Tejedor et al., 2016]. The question we pose here is whether there exists a first order organizational principle behind the self-organization of river deltas and whether this principle can be unraveled from the co-evolving topo-dynamic structure encoded in the delta planform. To answer this question, we introduce a new metric, the nonlocal Entropy Rate (nER) that captures the information content of a delta network in terms of the degree of uncertainty in delivering fluxes from any point of the network to the shoreline. We hypothesize that if the "guiding principle" of undisturbed deltas is to efficiently and robustly build land by increasing the diversity of their flux pathways over the delta plane, then they would exhibit maximum nonlocal Entropy Rate at states at which geometry and flux dynamics are at equilibrium. At the same time, their nER would be non-optimal at transient states, such as before and after major avulsions during which topology and dynamics adjust to each other to reach a new equilibrium state. We will present our results for field and simulated deltas, which confirm this hypothesis and open up new ways of thinking about self-organization, complexity and robustness in river deltas. One particular connection of interest might have important implications since entropy rate and resilience are related by the fluctuation theorem [Demetrius and Manke, 2005], and therefore our results suggest that deltas might in fact self-organize to maximize their resilience to structural and dynamic perturbations. References: Tejedor, A., A. Longjas, I. Zaliapin, and E. Foufoula

  4. Monte Carlo simulations of the stability of delta-Pu

    CERN Document Server

    Landa, A; Ruban, A

    2003-01-01

    The transition temperature (T sub c) for delta-Pu has been calculated for the first time. A Monte Carlo method is employed for this purpose and the effective cluster interactions are obtained from first-principles calculations incorporated with the Connolly-Williams and generalized perturbation methods. It is found that at T sub c approx 548 K, delta-Pu undergoes transformation from a disordered magnetic state to a structure with an antiferromagnetic spin alignment that is mechanically unstable with respect to tetragonal distortion. The calculated transition temperature is in good agreement with the temperature measured at the gamma -> delta transition (593 K). (letter to the editor)

  5. Exploring laser-guided metal deposition through a microbe metabolite

    OpenAIRE

    2009-01-01

    Purpose: The purpose of the paper is to describe exploring laser-guided metal deposition through a microbe metabolite.Design/methodology/approach: A maskless micro-fabrication of laser-guided deposition process through the metabolite of Acidophilic bacteria Thiobacillus ferrooxidans (T.f.) is explored.Findings: The authors have conducted an analysis of the metal deposition process using the point thermal-source of the Nd:YAG laser through the metabolite of Acidophilic bacteria Thiobacillus. A...

  6. Differences between human plasma and serum metabolite profiles.

    Directory of Open Access Journals (Sweden)

    Zhonghao Yu

    Full Text Available BACKGROUND: Human plasma and serum are widely used matrices in clinical and biological studies. However, different collecting procedures and the coagulation cascade influence concentrations of both proteins and metabolites in these matrices. The effects on metabolite concentration profiles have not been fully characterized. METHODOLOGY/PRINCIPAL FINDINGS: We analyzed the concentrations of 163 metabolites in plasma and serum samples collected simultaneously from 377 fasting individuals. To ensure data quality, 41 metabolites with low measurement stability were excluded from further analysis. In addition, plasma and corresponding serum samples from 83 individuals were re-measured in the same plates and mean correlation coefficients (r of all metabolites between the duplicates were 0.83 and 0.80 in plasma and serum, respectively, indicating significantly better stability of plasma compared to serum (p = 0.01. Metabolite profiles from plasma and serum were clearly distinct with 104 metabolites showing significantly higher concentrations in serum. In particular, 9 metabolites showed relative concentration differences larger than 20%. Despite differences in absolute concentration between the two matrices, for most metabolites the overall correlation was high (mean r = 0.81±0.10, which reflects a proportional change in concentration. Furthermore, when two groups of individuals with different phenotypes were compared with each other using both matrices, more metabolites with significantly different concentrations could be identified in serum than in plasma. For example, when 51 type 2 diabetes (T2D patients were compared with 326 non-T2D individuals, 15 more significantly different metabolites were found in serum, in addition to the 25 common to both matrices. CONCLUSIONS/SIGNIFICANCE: Our study shows that reproducibility was good in both plasma and serum, and better in plasma. Furthermore, as long as the same blood preparation procedure is

  7. Novel pyrazine metabolites found in polymyxin biosynthesis by Paenibacillus polymyxa

    DEFF Research Database (Denmark)

    Beck, Hans Christian; Hansen, Anne M; Lauritsen, Frants R

    2003-01-01

    A complex mixture of methyl-branched alkyl-substituted pyrazines was found in the growth medium of the polymyxin-producing bacterium Paenibacillus polymyxa, and of these, seven are new natural compounds. A total of 19 pyrazine metabolites were identified. The dominant metabolite was 2...... supplementation. The other pyrazine metabolites, all related pyrazines with either one, two or three alkyl substituents, were identified by means of their mass spectral data and/or co-elution with authentic standards....

  8. Metabolite Profiles of Lactic Acid Bacteria in Grass Silage▿

    OpenAIRE

    Broberg, Anders; Jacobsson, Karin; Ström, Katrin; Schnürer, Johan

    2007-01-01

    The metabolite production of lactic acid bacteria (LAB) on silage was investigated. The aim was to compare the production of antifungal metabolites in silage with the production in liquid cultures previously studied in our laboratory. The following metabolites were found to be present at elevated concentrations in silos inoculated with LAB strains: 3-hydroxydecanoic acid, 2-hydroxy-4-methylpentanoic acid, benzoic acid, catechol, hydrocinnamic acid, salicylic acid, 3-phenyllactic acid, 4-hydro...

  9. In vivo metabolite compartmentalization probed using intracellular GdDTPA

    DEFF Research Database (Denmark)

    Peters, David Alberg; Rowland, Ian

    Fast trans-membrane water exchange enables in- tracellular relaxation enhancement of water by contrast agents in the extracellular space. For me- tabolites not in fast exchange across membranes, intracellular metabolite relaxation enhancement will only occur if the contrast agent and metabolite a...... are in the same compartment. Extracellular contrast has utilized electroporation methods to deliver GdDTPA into the cytosol of rat muscle in vivo in order to probe the intracellular compart- mentalization of MR-visible metabolites....

  10. Benzene metabolites induce apoptosis in lymphocytes.

    Science.gov (United States)

    Martínez-Velázquez, M; Maldonado, V; Ortega, A; Meléndez-Zajgla, J; Albores, A

    2006-08-01

    Benzene is an important environmental pollutant with important health implications. Exposure to this aromatic hydrocarbon is associated with hematotoxicity, and bone marrow carcinogenic effects. It has been shown that benzene induces oxidative stress, cell cycle alterations, and programmed cell death in cultured cells. Hepatic metabolism of benzene is thought to be a prerequisite for its bone marrow toxicity. Nevertheless, there are no reports on the cellular effects of reactive intermediates derived from hepatic metabolism of benzene. Thus, the goal of this project was to determine the cellular alterations of benzene metabolites produced by the cultured hepatic cell line HepG2. Supernatants collected from these cells were applied to a culture of freshly isolated lymphocytes. A higher decrease in cell viability was found in cells exposed to these supernatants than to unmetabolized benzene. This viability decrease was due to apoptosis, as determined by Terminal deoxynucleotidyl Transferase Biotin-dUTP Nick End Labeling (TUNEL) assay and internucleosomal fragmentation of DNA. When supernatants were analyzed by HPLC, we found that not all the hydrocarbon was biotransformed, since a 28 microM concentration (37%) remained. The only metabolite found in the culture medium was muconic acid. The present results show that muconic acid derived from benzene metabolism is able to cooperate with the pollutant for the induction of apoptosis in rat lymphocytes.

  11. Urinary estrogen metabolites and breast cancer

    DEFF Research Database (Denmark)

    Dallal, Cher M; Stone, Roslyn A; Cauley, Jane A

    2013-01-01

    Background: Circulating estrogens are associated with increased breast cancer risk, yet the role of estrogen metabolites in breast carcinogenesis remains unclear. This combined analysis of 5 published studies evaluates urinary 2-hydroxyestrone (2-OHE1), 16a-hydroxyestrone (16a-OHE1......), and their ratio (2:16a-OHE1) in relation to breast cancer risk. ¿Methods: Primary data on 726 premenopausal women (183 invasive breast cancer cases and 543 controls) and 1,108 postmenopausal women (385 invasive breast cancer cases and 723 controls) were analyzed. Urinary estrogen metabolites were measured using...... premenopausal 2:16a-OHE1 was suggestive of reduced breast cancer risk overall (study-adjusted ORIIIvsI=0.80; 95% CI: 0.49-1.32) and for estrogen receptor negative (ER-) subtype (ORIIIvsI=0.33; 95% CI: 0.13-0.84). Among postmenopausal women, 2:16a-OHE1 was unrelated to breast cancer risk (study-adjusted ORIIIvs...

  12. Genomic organization of the human T-cell antigen-receptor alpha/delta locus.

    Science.gov (United States)

    Satyanarayana, K; Hata, S; Devlin, P; Roncarolo, M G; De Vries, J E; Spits, H; Strominger, J L; Krangel, M S

    1988-11-01

    Two clusters of overlapping cosmid clones comprising about 100 kilobases (kb) at the human T-cell antigen-receptor alpha/delta locus were isolated from a genomic library. The structure of the germ-line V delta 1 variable gene segment was determined. V delta 1 is located 8.5 kb downstream of the V alpha 13.1 gene segment, and both V segments are arranged in the same transcriptional orientation. The V alpha 17.1 segment is located between V delta 1 and the D delta, J delta, C delta region (containing the diversity, joining, and constant gene segments). Thus, V delta and V alpha segments are interspersed along the chromosome. The germ-line organization of the D delta 2, J delta 1, and J delta 2 segments was determined. Linkage of C delta to the J alpha region was established by identification of J alpha segments within 20 kb downstream of C delta. The organization of the locus was also analyzed by field-inversion gel electrophoresis. The unrearranged V delta 1 and D delta, J delta, C delta regions are quite distant from each other, apparently separated by a minimum of 175-180 kb.

  13. Expression profiling of peroxisome proliferator-activated receptor-delta (PPAR-delta) in mouse tissues using tissue microarray.

    Science.gov (United States)

    Higashiyama, Hiroyuki; Billin, Andrew N; Okamoto, Yuji; Kinoshita, Mine; Asano, Satoshi

    2007-05-01

    Peroxisome proliferator-activated receptor-delta (PPAR-delta) is known as a transcription factor involved in the regulation of fatty acid oxidation and mitochondrial biogenesis in several tissues, such as skeletal muscle, liver and adipose tissues. In this study, to elucidate systemic physiological functions of PPAR-delta, we examined the tissue distribution and localization of PPAR-delta in adult mouse tissues using tissue microarray (TMA)-based immunohistochemistry. PPAR-delta positive signals were observed on variety of tissues/cells in multiple systems including cardiovascular, urinary, respiratory, digestive, endocrine, nervous, hematopoietic, immune, musculoskeletal, sensory and reproductive organ systems. In these organs, PPAR-delta immunoreactivity was generally localized on the nucleus, although cytoplasmic localization was observed on several cell types including neurons in the nervous system and cells of the islet of Langerhans. These expression profiling data implicate various physiological roles of PPAR-delta in multiple organ systems. TMA-based immunohistochemistry enables to profile comprehensive protein localization and distribution in a high-throughput manner.

  14. Regulation of Vascular and Renal Function by Metabolite Receptors*

    Science.gov (United States)

    Peti-Peterdi, János; Kishore, Bellamkonda K.; Pluznick, Jennifer L.

    2016-01-01

    To maintain metabolic homeostasis, the body must be able to monitor the concentration of a large number of substances, including metabolites, in real time and to use that information to regulate the activities of different metabolic pathways. Such regulation is achieved by the presence of sensors, termed metabolite receptors, in various tissues and cells of the body, which in turn convey the information to appropriate regulatory or positive or negative feedback systems. In this review, we cover the unique roles of metabolite receptors in renal and vascular function. These receptors play a wide variety of important roles in maintaining various aspects of homeostasis—from salt and water balance to metabolism—by sensing metabolites from a wide variety of sources. We discuss the role of metabolite sensors in sensing metabolites generated locally, metabolites generated at distant tissues or organs, or even metabolites generated by resident microbes. Metabolite receptors are also involved in various pathophysiological conditions and are being recognized as potential targets for new drugs. By highlighting three receptor families—(a) citric acid cycle intermediate receptors, (b) purinergic receptors, and (c) short-chain fatty acid receptors—we emphasize the unique and important roles that these receptors play in renal and vascular physiology and pathophysiology. PMID:26667077

  15. Regulation of Vascular and Renal Function by Metabolite Receptors.

    Science.gov (United States)

    Peti-Peterdi, János; Kishore, Bellamkonda K; Pluznick, Jennifer L

    2016-01-01

    To maintain metabolic homeostasis, the body must be able to monitor the concentration of a large number of substances, including metabolites, in real time and to use that information to regulate the activities of different metabolic pathways. Such regulation is achieved by the presence of sensors, termed metabolite receptors, in various tissues and cells of the body, which in turn convey the information to appropriate regulatory or positive or negative feedback systems. In this review, we cover the unique roles of metabolite receptors in renal and vascular function. These receptors play a wide variety of important roles in maintaining various aspects of homeostasis-from salt and water balance to metabolism-by sensing metabolites from a wide variety of sources. We discuss the role of metabolite sensors in sensing metabolites generated locally, metabolites generated at distant tissues or organs, or even metabolites generated by resident microbes. Metabolite receptors are also involved in various pathophysiological conditions and are being recognized as potential targets for new drugs. By highlighting three receptor families-(a) citric acid cycle intermediate receptors, (b) purinergic receptors, and

  16. Global metabolite analysis of yeast: evaluation of sample preparation methods

    DEFF Research Database (Denmark)

    Villas-Bôas, Silas Granato; Højer-Pedersen, Jesper; Åkesson, Mats Fredrik;

    2005-01-01

    , which is the analysis of a large number of metabolites with very diverse chemical and physical properties. This work reports the leakage of intracellular metabolites observed during quenching yeast cells with cold methanol solution, the efficacy of six different methods for the extraction...... of intracellular metabolites, and the losses noticed during sample concentration by lyophilization and solvent evaporation. A more reliable procedure is suggested for quenching yeast cells with cold methanol solution, followed by extraction of intracellular metabolites by pure methanol. The method can be combined...

  17. Consumption and quantitation of delta9-tetrahydrocannabinol in commercially available hemp seed oil products.

    Science.gov (United States)

    Bosy, T Z; Cole, K A

    2000-10-01

    There has been a recent and significant increase in the use and availability of hemp seed oil products. These products are being marketed as a healthy source of essential omega fatty acids when taken orally. Although the health aspects of these oils is open to debate, the probability that oils derived from the hemp seed will contain delta9-tetrahyrdocannabinol (THC) is noteworthy. Recent additions to the literature cite a number of studies illustrating that the ingestion of these products results in urinary levels of the THC metabolite, delta9-tetrahyrdocannabinol carboxylic acid (THCA), well above the administrative cutoff (50 ng/mL) used during random drug screens. Testing performed by our laboratory found that the concentration of THC in hemp oil products has been reduced considerably since the publication of earlier studies. The purpose of this study is to quantitate the THC levels in commercially available hemp oils and to administer those oils tested to THC-free volunteers to determine urine metabolite levels following several 15-g doses. Two extraction protocols were evaluated for removing THC from the oil matrix: a single step liquid-liquid extraction was compared to a two-phase process using both liquid-liquid and solid-phase techniques. Gas chromatography-mass spectrometry was used to determine THC levels in several products: four from Spectrum Essentials (3 bottled oils and 1-g capsules), two from Health from the Sun (1-g capsules and bottled oil) oils, and single samples of both Hempstead and Hempola hemp oils. These hemp oil products contained THC concentrations of 36.0, 36.4, 117.5, 79.5, 48.6, 45.7, 21.0, and 11.5 mg/g, respectively. The Abbott AxSYM FPIA and Roche On-Line KIMS immunoassays were used to screen the urine samples, and GC-MS was used to determine the amount of THC in each oil as well as confirm and quantitate THCA in the urine of study participants immediately before and 6 h after each dose. Peak THCA levels in the participants' urine

  18. Sharecropping Contract Experience in Delta State, Nigeria

    Institute of Scientific and Technical Information of China (English)

    Albert Ukaro Ofuoku

    2015-01-01

    Sharecropping has been an age long practice from ancient times. Some scholars saw the practice as being exploitative of the tenants, yet it is still being practiced. The reasons behind it continual practice need to be unveiled. This study was therefore conducted to examine the sharecropping contract experience in Delta State, Nigeria. The landlords decided to practice sharecropping as a result of emigration of their household members, farm size and cost of labours, some of them gave age and their primary occupation as factors for their decisions to opt for sharecropping arrangement. The yields were shared on the basis of 60% for the landlord to 40% for the tenant. The landlords provided all the equipment and inputs, while the tenant's carried out all the farm operations. They faced the constraints of stress, but were able to cope with them, because of hospitals and health centres nearby. The result of the test of hypothesis confirmed the reasons given for deciding on sharecropping arrangement. It was concluded that sharecropping was not exploitative. It was recommended that the practice of sharecropping should be encouraged and not diversified into other sources of livelihood should do so.

  19. The DELTA 181 lithium thionyl chloride battery

    Science.gov (United States)

    Sullivan, Ralph M.; Brown, Lawrence E.; Leigh, A. P.

    In 1986, the Johns Hopkins University/Applied Physics Laboratory (JHU/APL) undertook the development of a sensor module for the DELTA 181 spacecraft, a low earth orbit (LEO) mission of less than two months duration. A large lithium thionyl chloride battery was developed as the spacecraft's primary power source, the first known such use for this technology. The exceptionally high energy density of the lithium thionyl chloride cell was the primary driver for its use, resulting in a completed battery with a specific energy density of 120 Wh/lb. Safety requirements became the primary driver shaping all aspects of the power system design and development due to concerns about the potential hazards of this relatively new, high-energy technology. However, the program was completed without incident. The spacecraft was launched on February 8, 1988, from Kennedy Space Center (KSC) with over 60,000 Wh of battery energy. It reentered on April 2, 1988, still operating after 55 days, providing a successful, practical, and visible demonstration of the use of this technology for spacecraft applications.

  20. Delta Haptic Device as a nanomanipulator

    Science.gov (United States)

    Grange, Sebastien; Conti, Francois; Helmer, Patrick; Rouiller, Patrice; Baur, Charles

    2001-10-01

    At the EPFL, we have developed a force-feedback device and control architecture for high-end research and industrial applications. The Delta Haptic Device (DHD) consists of a 6 degrees-of-freedom (DOF) mecatronic device driven by a PC. Several experiments have been carried out in the fields of manipulation and simulation to assess the dramatic improvement haptic information brings to manipulation. This system is particularly well suited for scaled manipulation such as micro-, nano- and biomanipulation. Not only can it perform geometric and force scaling, but it can also include fairly complex physical models into the control loop to assist manipulation and enhance human understanding of the environment. To demonstrate this ability, we are currently interfacing our DHD with an atomic force microscope (AFM). In a first stage, we will be able to feel in real-time the topology of a given sample while visualizing it in 3D. The aim of the project is to make manipulation of carbon nanotubes possible by including physical models of such nanotubes behavior into the control loop, thus allowing humans to control complex structures. In this paper, we give a brief description of our device and present preliminary results of its interfacing with the AFM.

  1. Delta Morphodynamics Matters! Ecosystem Services, Poverty and Morphodynamic Change in the Ganges-Brahmaputra Mega-Delta

    Science.gov (United States)

    Nicholls, R. J.; Adger, N.; Allan, A.; Darby, S. E.; Hutton, C.; Matthews, Z.; Rahman, M.; Whitehead, P. G.; Wolf, J.

    2013-12-01

    The world's deltas are probably the most vulnerable type of coastal environment, and they face multiple stresses in the coming decades. These stresses include, amongst others, local drivers due to land subsidence, population growth and urbanisation within the deltas, regional drivers due to changes in catchment management (e.g. upstream land use and dam construction), as well as global climate change impacts such as sea-level rise. At the same time, the ecosystem services of river deltas support high population densities, with around 14% of the global population inhabiting deltas. A large proportion of these people experience extremes of poverty and they are therefore severely exposed to vulnerability from environmental and ecological stress and degradation. In areas close to or below the poverty boundary, both subsistence and cash elements of the economy tend to rely disproportionately heavily on ecosystem services which underpin livelihoods. Therefore, to sustainably manage delta environments they must be viewed as complex social-environmental systems where change is only partially driven by physical drivers such as sea level rise and climate change, and human-induced development activities are also critical. Here we outline a new conceptual framework for the development of methods to understand and characterise the key drivers of change in ecosystem services that affect the environment and economic status of populous deltas, focusing specifically on the Ganges-Brahmaputra-Meghna (GBM) mega-delta. The GBM delta is characterised by densely populated coastal lowlands with significant poverty, with livelihoods supported to a large extent by natural ecosystems such as the Sunderbahns (the largest mangrove forest in the world). However, the GBM delta is under severe development pressure due to many growing cities. At present the importance of ecosystems services to poverty and livelihoods is poorly understood. This is due to due to the complexity of interactions

  2. EAARL Coastal Topography--Pearl River Delta 2008: First Surface

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — A first surface elevation map (also known as a Digital Elevation Model, or DEM) of the Pearl River Delta in Louisiana and Mississippi was produced from remotely...

  3. EAARL Coastal Topography--Pearl River Delta 2008: Bare Earth

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — A bare earth elevation map (also known as a Digital Elevation Model, or DEM) of the Pearl River Delta in Louisiana and Mississippi was produced from remotely sensed,...

  4. GPC Using a Delta-Domain Emulator-Based Approach

    DEFF Research Database (Denmark)

    Lauritsen, Morten Bach; Jensen, Morten Rostgaard; Poulsen, Niels Kjølstad

    1997-01-01

    This paper describes new approaches to generalized predictive control formulated in the delta (delta) domain. A new delta-domain version of the continuous-time emulator-based predictor is presented. It is shown to contain the optimal discrete-time predictor based on incomplete information...... as a special case. Usually, a good estimate is obtained in a much longer range of samples than obtained by the optimal predictor of the same complexity. This is particularly advantageous at fast sampling rates where a `conventional' predictor is bound to become very computationally demanding. Two controllers...... are considered: one having a well-defined limit as the sampling period tends to zero, the other being a close approximation to the conventional discrete-time GPC. Both algorithms are discrete in nature and well-suited for adaptive control. The fact that delta-domain models are used does not introduce...

  5. Yukon Delta National Wildlife Refuge : Narrative Report : Calendar Year 1990

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Yukon Delta National Wildlife Refuge outlines Refuge accomplishments during the 1990 calendar year. The report begins with a summary...

  6. Delta- Sigma Modulator with Signal Dependant Feedback Gain

    National Research Council Canada - National Science Library

    K.Diwakar; V.Vinoth Kumar

    2015-01-01

    Higher order Delta-Sigma Modulator (DSM) is basically an unstable system. The approximate conditions for stability cannot be used for the design of a DSM for industrial applications where risk is involved...

  7. A High Performance Delta-Sigma Modulator for Neurosensing

    National Research Council Canada - National Science Library

    Xu, Jian; Zhao, Menglian; Wu, Xiaobo; Islam, Md Kafiul; Yang, Zhi

    2015-01-01

    ... to achieve and would require excessive circuit area and power for implementation. In this paper, we present a high performance Delta-Sigma modulator along with several design techniques and enabling blocks to reduce circuit area and power...

  8. An integrated delta-sigma based IIR filter

    Science.gov (United States)

    Au, Dennis Kin-Wah

    Delta-sigma based infinite impulse response (IIR) filters are a recently developed circuit technique for efficiently realizing IIR filters operating directly on oversampled delta-sigma modulated signals. The design and single-chip implementation of a fifth-order delta-sigma based IIR filter are described. The filter coefficients are fully programmable and with the use of a structure that is inherently scaled for dynamic range, good filter performance is maintained over a wide variety of transfer functions. To eliminate multi-bit multiplications, five second-order digital delta-sigma modulators were used and dynamic range improvement was obtained through the use of multi-bit quantizers in these modulators. The filter was implemented as a very large scale integration chip using 1.2 micron complementary metal oxide semiconductor technology, occupying an area of 4,355 by 5,962 square microns. Simulations indicate that the clock range should operate up to 45 MHz.

  9. Yukon Delta National Wildlife Refuge coastal survey, final report

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Aerial surveys were conducted along the coastline of the Yukon Delta National Wildlife Refuge to determine the distribution and abundance of waterfowl and...

  10. Alternative Interpretation for the Eberswalde Delta, Holden NE Crater, Mars

    Science.gov (United States)

    Fedo, C. M.; Finkelstein, D. B.; Moersch, J. E.

    2008-03-01

    Examination of HiRISE images from the Eberswalde Delta reveal that it is hard to identify sedimentologic and stratigraphic components of a fluvio-deltaic system, leaving open alternative interpretations for the origin of the strata and geomorphpology.

  11. Linear delta expansion technique for the solution of anharmonic oscillations

    Indian Academy of Sciences (India)

    P K Bera; J Datta

    2007-01-01

    The linear delta expansion technique has been developed for solving the differential equation of motion for symmetric and asymmetric anharmonic oscillators. We have also demonstrated the sophistication and simplicity of this new perturbation technique.

  12. Lead analysis of waterfowl from Yukon Delta NWR

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — In 1995, WAES received funds from the Yukon Delta Ecosystem Team to analyze livers of waterfowl, other than spectacled eiders, for lead concentrations. Nineteen...

  13. LiDAR data for the Delta Area of California

    Data.gov (United States)

    California Department of Resources — LiDAR data for the Delta Area of California from the California Department of Water Resources. Bare earth grids from LiDAR.This data is in ESRI Grid format with 2...

  14. Yukon Delta National Wildlife Refuge : Narrative Report : Calendar Year 1992

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Yukon Delta National Wildlife Refuge outlines Refuge accomplishments during the 1992 calendar year. The report begins with a summary...

  15. Migratory Bird Avian Influenza Sampling; Yukon Kuskokwim Delta, Alaska, 2015

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Data set containing avian influenza sampling information for spring and summer waterbirds on the Yukon Kuskokwim Delta, 2015. Data contains sample ID, species common...

  16. Delta and Breton National Wildlife Refuges: Comprehensive Conservation Plan

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This Comprehensive Conservation Plan (CCP) was written to guide management on Delta and Breton NWRs for the next 15 years. This plan outlines the refuges' vision and...

  17. Yukon Delta National Wildlife Refuge : Narrative Report : Calendar Year 1995

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Yukon Delta National Wildlife Refuge outlines Refuge accomplishments during the 1995 calendar year. The report begins with a summary...

  18. EAARL Coastal Topography--Pearl River Delta 2008: Bare Earth

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — A bare earth elevation map (also known as a Digital Elevation Model, or DEM) of the Pearl River Delta in Louisiana and Mississippi was produced from remotely sensed,...

  19. Topography data from the Elwha River delta, Washington, September 2014

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This part of the data release presents topography data from the Elwha River delta collected in September 2014. Topography data were collected on foot with global...

  20. Calculating Lake Morphology in the Colville River Delta, Alaska

    Science.gov (United States)

    McGraw, M.; Walker, H. J.

    2013-12-01

    The morphology and surface area of a lake can be determined using simple mathematical formulas. These formulas can be plugged into a Geographic Information System (GIS) and used to calculate the circularity, smoothness, compactness and orientation of a lake or pond in remotely sensed imagery. The calculated output can then be used to differentiate circular lakes from elongated lakes, lakes with smooth shorelines from those with complex shorelines, and lake orientation; such information can then be used to classify and quantify different types of lakes in complex environments such as river deltas. The Colville River delta is located on the North Slope of Arctic Alaska. Previous studies have classified the delta's 230,000+ lakes into five types: 1. thermokarst (thaw) lakes, 2. oriented lakes, 3. perched lakes, 4 channel lakes and 5. ice-wedge polygon ponds. This study uses 2004 aerial photography and 2011 satellite imagery to quantify the different types of lake in the delta.

  1. Water Quality Assessment of River Areba, Niger Delta, Nigeria ...

    African Journals Online (AJOL)

    Water Quality Assessment of River Areba, Niger Delta, Nigeria Using Physical ... phosphate (0.78mg/l) were above World Health Organization limits for drinking water. Seasonally, water temperatures, total dissolved solids, biological oxygen ...

  2. Yukon Delta National Wildlife Refuge : Narrative Report : Calendar Year 1983

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Yukon Delta National Wildlife Refuge outlines Refuge accomplishments during the 1983 calendar year. The report begins with a summary...

  3. Hypertension in a Rural Community in Rivers State, Niger Delta ...

    African Journals Online (AJOL)

    Hypertension in a Rural Community in Rivers State, Niger Delta Region of Nigeria: ... (SSA), is now a serious endemic threat and an important public health issue. ... Medical history such as prior knowledge of blood pressure status and family ...

  4. Yukon Delta National Wildlife Refuge : Narrative Report : Calendar Year 1994

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Yukon Delta National Wildlife Refuge outlines Refuge accomplishments during the 1994 calendar year. The report begins with a summary...

  5. Yukon Delta National Wildlife Refuge : Narrative Report : Calendar Year 1987

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Yukon Delta National Wildlife Refuge outlines Refuge accomplishments during the 1987 calendar year. The report begins with a summary...

  6. Yukon Delta National Wildlife Refuge : Narrative Report : Calendar Year 2001

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Yukon Delta National Wildlife Refuge outlines Refuge accomplishments during the 2001 calendar year. The report begins with a summary...

  7. Yukon Delta National Wildlife Refuge : Narrative Report : Calendar Year 1986

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Yukon Delta National Wildlife Refuge outlines Refuge accomplishments during the 1986 calendar year. The report begins with a summary...

  8. Birds and mammals of the Copper River Delta

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The objectives of this report are: (1) to describe the habitats available for birds and mammals on the Copper River Delta (2) to present an annotated list of birds...

  9. Inventory Management in Delta Allied Wire Industries Limited Asaba ...

    African Journals Online (AJOL)

    Inventory Management in Delta Allied Wire Industries Limited Asaba. ... review and customers' handling processes equally studied for improvement. The data collated were collated were analyzed using the Economic Order Quantity (EOQ) ...

  10. Profiling risk and sustainability in coastal deltas of the world

    Science.gov (United States)

    Tessler, Z. D.; Vörösmarty, C. J.; Grossberg, M.; Gladkova, I.; Aizenman, H.; Syvitski, J. P. M.; Foufoula-Georgiou, E.

    2015-08-01

    Deltas are highly sensitive to increasing risks arising from local human activities, land subsidence, regional water management, global sea-level rise, and climate extremes. We quantified changing flood risk due to extreme events using an integrated set of global environmental, geophysical, and social indicators. Although risks are distributed across all levels of economic development, wealthy countries effectively limit their present-day threat by gross domestic product-enabled infrastructure and coastal defense investments. In an energy-constrained future, such protections will probably prove to be unsustainable, raising relative risks by four to eight times in the Mississippi and Rhine deltas and by one-and-a-half to four times in the Chao Phraya and Yangtze deltas. The current emphasis on short-term solutions for the world’s deltas will greatly constrain options for designing sustainable solutions in the long term.

  11. EAARL Coastal Topography--Pearl River Delta 2008: First Surface

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — A first surface elevation map (also known as a Digital Elevation Model, or DEM) of the Pearl River Delta in Louisiana and Mississippi was produced from remotely...

  12. LiDAR data for the Delta Area of California

    Data.gov (United States)

    California Department of Resources — LiDAR data for the Delta Area of California from the California Department of Water Resources. Bare earth grids from LiDAR.This data is in ESRI Grid format with 2...

  13. Yukon Delta National Wildlife Refuge : Narrative Report : Calendar Year 1998

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Yukon Delta National Wildlife Refuge outlines Refuge accomplishments during the 1998 calendar year. The report begins with a summary...

  14. Yukon Delta National Wildlife Refuge : Narrative Report : Calendar Year 2002

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Yukon Delta National Wildlife Refuge outlines Refuge accomplishments during the 2002 calendar year. The report begins with a summary...

  15. Yukon Delta National Wildlife Refuge : Narrative Report : Calendar Year 1996

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Yukon Delta National Wildlife Refuge outlines Refuge accomplishments during the 1996 calendar year. The report begins with a summary...

  16. Yukon Delta National Wildlife Refuge : Narrative Report : Calendar Year 1997

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Yukon Delta National Wildlife Refuge outlines Refuge accomplishments during the 1997 calendar year. The report begins with a summary...

  17. Yukon Delta National Wildlife Refuge : Narrative Report : Calendar Year 1982

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Yukon Delta, Nunivak National Wildlife Refuge outlines Refuge accomplishments during the 1982 calendar year. The report begins with...

  18. Yukon Delta National Wildlife Refuge : Narrative Report : Calendar Year 1989

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Yukon Delta National Wildlife Refuge outlines Refuge accomplishments during the 1989 calendar year. The report begins with a summary...

  19. The Byron Syring DELTA Center--Leadership in Action.

    Science.gov (United States)

    Snyder, Timothy

    1997-01-01

    Byron Spring DELTA Center serves a small farming community in Colorado offers high school diploma programs, English-as-a-Second-Language courses, lifelong learning, and a variety of other programs for teens and adults. (JOW)

  20. Rarotonga Radiocarbon (delta 14C) for 1950 to 1997

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Rarotonga coral radiocarbon (14C) timeseries. Coral radiocarbon (Delta-14C) on untreated, low-speed drilled samples. Precision is +/- 4 per mil as documented by an...

  1. precise delta extraction scheme for reprogramming of wireless ...

    African Journals Online (AJOL)

    eobe

    Keywords- reprogramming; operating system, wireless sensor network, Delta. 1. ... implemented via the use of embedded operating systems. Jun-Zhao in [6] as well as Dunkiels et al. in [7] ..... Pister, “System architecture directions for.

  2. Yukon Delta National Wildlife Refuge : Narrative Report : Calendar Year 1999

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Yukon Delta National Wildlife Refuge outlines Refuge accomplishments during the 1999 calendar year. The report begins with a summary...

  3. Yukon Delta National Wildlife Refuge : Narrative Report : Calendar Year 2000

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Yukon Delta National Wildlife Refuge outlines Refuge accomplishments during the 2000 calendar year. The report begins with a summary...

  4. Morphologic and stratigraphic evolution of muddy ebb-tidal deltas along a subsiding coast: Barataria Bay, Mississippi River delta

    Science.gov (United States)

    FitzGerald, D.M.; Kulp, M.; Penland, S.; Flocks, J.; Kindinger, J.

    2004-01-01

    The Barataria barrier coast formed between two major distributaries of the Mississippi River delta: the Plaquemines deltaic headland to the east and the Lafourche deltaic headland to the west. Rapid relative sea-level rise (1??03 cm year-1) and other erosional processes within Barataria Bay have led to substantial increases in the area of open water (> 775 km2 since 1956) and the attendant bay tidal prism. Historically, the increase in tidal discharge at inlets has produced larger channel cross-sections and prograding ebb-tidal deltas. For example, the ebb delta at Barataria Pass has built seaward > 2??2 km since the 1880s. Shoreline erosion and an increasing bay tidal prism also facilitated the formation of new inlets. Four major lithofacies characterize the Barataria coast ebb-tidal deltas and associated sedimentary environments. These include a proximal delta facies composed of massive to laminated, fine grey-brown to pale yellow sand and a distal delta facies consisting of thinly laminated, grey to pale yellow sand and silty sand with mud layers. The higher energy proximal delta deposits contain a greater percentage of sand (75-100%) compared with the distal delta sediments (60-80%). Associated sedimentary units include a nearshore facies consisting of horizontally laminated, fine to very fine grey sand with mud layers and an offshore facies that is composed of grey to dark grey, laminated sandy silt to silty clay. All facies coarsen upwards except the offshore facies, which fines upwards. An evolutionary model is presented for the stratigraphic development of the ebb-tidal deltas in a regime of increasing tidal energy resulting from coastal land loss and tidal prism growth. Ebb-tidal delta facies prograde over nearshore sediments, which interfinger with offshore facies. The seaward decrease in tidal current velocity of the ebb discharge produces a gradational contact between proximal and distal tidal delta facies. As the tidal discharge increases and the inlet

  5. The late-Holocene progradation of the Mahakam Delta, Indonesia - A case study of tidal, tropical deltas

    Science.gov (United States)

    Dalman, R.; Ranawijaya, D.; Missiaen, T.; Kroonenberg, S.; Storms, J.

    2011-12-01

    The Mahakam Delta is an oft-cited example of a mixed fluvial-tidally influenced delta. Yet the distinct separation of the tide-dominated delta plain and the fluvial distributaries make the delta unique amongst tidally influenced deltas. The delta prograded an average of 60 km over the last 5000 years. Most sediment transport is induced by tidal currents and fluvial discharge, which resulted in a distinct, dense network of distributary and tidal channels. In order to characterize the Holocene sedimentary architecture we describe a dataset of 10 new cores and a large survey of very high-resolution, shallow seismics. The seismics are recorded using an echosounder with a novel parametric source, allowing subsurface penetration in excess of 15 m while achieving a vertical resolution of 0.2 m. Distinct sedimentary facies are described in detail for delta plain, delta front, distributary and mouthbar deposits. A notable difference in stratal pattern has been observed between the inner and outer tide-dominated delta plain facies. The inner tidal channels cut deeply into the underlying deltafront deposits and form a distinct heterogenic laterally accreting and intercutting facies. Whereas the outer tide-dominated delta plain deposits accrete conformably on the marine deltafront facies and show a much more homogenous sedimentary architecture. The continual reworking of the inner tide-dominated delta plain results in a patchwork of deposits greatly varying in thickness and age albeit with a similar silty clay lithology. The area of the present-day delta was largely flooded after the early to mid-Holocene transgression, our data indicate that a small branch of fluvial distributaries was active on the current delta plain around 5 ka. Subsequently, the northernmost fluvial distributary built out rapidly over a period of 3 kyrs. The southern distributaries built out later, from 2 ka to the present. The mouthbar deposits in the south are significantly thicker than in the northern

  6. Longitudinal spin asymmetries and $\\Delta G$ at COMPASS

    CERN Document Server

    Le Goff, Jean-Marc

    2008-01-01

    The spin structure $g_{1}$ of the deuteron has been measured by COMPASS with unprecedented accuracy at low $x$, providing much more reliable values for the first moment $\\Gamma_{1}$ and for the quark spin contribution $\\Delta\\Sigma$. Difference-charge semi-inclusive asymmetries have been measured and seem to favor a flavor asymmetric polarized sea. The gluon polarization has been measured in the open-charm and high-$p_{t}$ channels. Large values of $\\Delta G$ are now unlikely.

  7. delta. t tuneup procedure for the LAMPF 805-MHz linac

    Energy Technology Data Exchange (ETDEWEB)

    Crandall, K.R.

    1976-05-01

    An important part of tuning the LAMPF accelerator is the adjustment of the phases and amplitudes in the 805-MHz linac. The technique used is called the ..delta..t procedure because of the time-of-flight measurements that are required. The theory behind the ..delta..t procedure, a brief description of the hardware, and a description of the many computer programs that have been written to implement the procedure are presented.

  8. Properties of the $\\delta$ Scorpii Circumstellar Disk from Continuum Modeling

    OpenAIRE

    Carciofi, A. C.; Miroshnichenko, A. S.; Kusakin, A. V.; Bjorkman, J. E.; Bjorkman, K. S.; Marang, F.; Kuratov, K.S.; a-Lario, P. Garcí; Calderón, J. V. Perea; Fabregat, J.; Magalhães, A.M.

    2006-01-01

    We present optical $WBVR$ and infrared $JHKL$ photometric observations of the Be binary system $\\delta$ Sco, obtained in 2000--2005, mid-infrared (10 and $18 \\mu$m) photometry and optical ($\\lambda\\lambda$ 3200--10500 \\AA) spectropolarimetry obtained in 2001. Our optical photometry confirms the results of much more frequent visual monitoring of $\\delta$ Sco. In 2005, we detected a significant decrease in the object's brightness, both in optical and near-infrared brightness, which is associate...

  9. Multimegawatt DAE$\\delta$ALUS Cyclotrons for Neutrino Physics

    CERN Document Server

    Abs, M; Alonso, J R; Barletta, W A; Barlow, R; Calabretta, L; Calanna, A; Campo, D; Celona, L; Conrad, J M; Gammino, S; Kleeven, W; Koeth, T; Maggiore, M; Okuno, H; Piazza, L A C; Seidel, M; Shaevitz, M H; Stingelin, L; Yang, J J; Yeck, J

    2012-01-01

    DAE$\\delta$ALUS (Decay-At-rest Experiment for $\\delta_{CP}$ studies At the Laboratory for Underground Science) provides a new approach to the search for CP violation in the neutrino sector. High-power continuous-wave proton cyclotrons efficiently provide the necessary proton beams with an energy of up to 800 MeV to create neutrinos from pion and muon decay-at-rest. The experiment searches for $\\bar{\

  10. Automatisierte VHDL-Code-Generierung eines Delta-Sigma Modulators

    Directory of Open Access Journals (Sweden)

    R. Spilka

    2006-01-01

    Full Text Available Im vorliegenden Beitrag wird eine automatische Generierung des VHDL-Codes eines Delta-Sigma Modulators präsentiert. Die Koeffizientenmultiplikation wird hierbei durch Bit-Serielle-Addition durchgeführt. Mit Hilfe zweier neuer Matlab Funktionen wird der Systementwurf durch die bekannte Delta-Sigma Toolbox von R. Schreier erweitert und direkt synthesefähiger VHDL Code erzeugt.

  11. Sedimentation patterns in floodplains of the Mekong Delta - Vietnam

    Science.gov (United States)

    Van Manh, Nguyen; Merz, Bruno; Viet Dung, Nguyen; Apel, Heiko

    2013-04-01

    Quantification of floodplain sedimentation during the flood season in the Mekong Delta (MD) plays a very important role in the assessment of flood deposits for a sustainable agro-economic development. Recent studies on floodplain sedimentation in the region are restricted to small pilot sites because of the large extend of the Delta, and the complex channel. This research aims at a quantification of the sediment deposition in floodplains of the whole Mekong Delta, and to access the impacts of the upstream basin development on the sedimentation in the Delta quantitatively. To achieve this, a suspended sediment transport model is developed based on the quasi-2D hydrodynamic model of the whole Mekong Delta developed by Dung et al. (2011). The model is calibrated and validated using observed data derived from several sediment measurement campaigns in channel networks and floodplains. Measured sediment data and hydrodynamic model quantify the spatio-temporal variability of sediment depositions in different spatial units: individual dyke compartments, and the sub-regions Plain of Reeds, Long Xuyen Quadrangle and the area between Tien River and Hau River. It is shown that the distribution of sediment deposition over the delta is highly depended on the flood magnitude, that in turn drives the operation policy of flood control systems in floodplains of the Mekong Delta. Thus, the sedimentation distribution is influenced by the protection level of the dyke systems in place and the distance to the Tien River and Hau River, the main branches of the Mekong in the Delta. This corroborates the main findings derived from data analysis obtained from a small scale test site by Hung et al, (2011, 2012a). Moreover, the results obtained here underlines the importance of the main channels for the sediment transport into the floodplains, and the deposition rate in floodplains is strongly driven by the intake locations and the distance from these to the main channels as well.

  12. An integrated assessment framework for land subsidence in delta cities

    Directory of Open Access Journals (Sweden)

    T. H. M. Bucx

    2015-11-01

    Full Text Available In many delta cities land subsidence exceeds absolute sea level rise up to a factor of ten by excessive groundwater extraction related to rapid urbanization and population growth. Without change, parts of Jakarta, Ho Chi Minh City, Bangkok and numerous other delta (and coastal cities will sink below sea level. Increased flooding and also other widespread impacts of land subsidence result already in damage of billions of dollars per year. In order to gain insight in the complex, multi-sectoral aspects of subsidence, to raise awareness and to support decision making on appropriate adaptation strategies and measures, an Integrated Assessment Framework (IAF for subsidence is introduced, illustrated by several (delta case studies. Based on that a list of 10 generic key issues and possible solutions is presented in order to further develop and support a (generic approach how to deal with subsidence in current and future subsidence-prone areas. For exchange of experiences and knowledge development.on subsidence in deltas the Delta Alliance, a knowledge network of deltas worldwide, can be supportive.

  13. Near-infrared spectropolarimetry of a delta-spot

    CERN Document Server

    Balthasar, H; Louis, R E; Verma, M; Denker, C

    2014-01-01

    Sunspots harboring umbrae of both magnetic polarities within a common penumbra (delta-spots) are often but not always related to flares. We present first near-infrared (NIR) observations (Fe I 1078.3 nm and Si I 1078.6 nm spectra) obtained with the Tenerife Infrared Polarimeter (TIP) at the Vacuum Tower Telescope (VTT) in Tenerife on 2012 June 17, which afford accurate and sensitive diagnostics to scrutinize the complex fields along the magnetic neutral line of a delta-spot within active region NOAA 11504. We examine the vector magnetic field, line-of-sight (LOS) velocities, and horizontal proper motions of this rather inactive delta-spot. We find a smooth transition of the magnetic vector field from the main umbra to that of opposite polarity (delta-umbra), but a discontinuity of the horizontal magnetic field at some distance from the delta-umbra on the polarity inversion line. The magnetic field decreases faster with height by a factor of two above the delta-umbra. The latter is surrounded by its own Eversh...

  14. An integrated assessment framework for land subsidence in delta cities

    Science.gov (United States)

    Bucx, T. H. M.; van Ruiten, C. J. M.; Erkens, G.; de Lange, G.

    2015-11-01

    In many delta cities land subsidence exceeds absolute sea level rise up to a factor of ten by excessive groundwater extraction related to rapid urbanization and population growth. Without change, parts of Jakarta, Ho Chi Minh City, Bangkok and numerous other delta (and coastal) cities will sink below sea level. Increased flooding and also other widespread impacts of land subsidence result already in damage of billions of dollars per year. In order to gain insight in the complex, multi-sectoral aspects of subsidence, to raise awareness and to support decision making on appropriate adaptation strategies and measures, an Integrated Assessment Framework (IAF) for subsidence is introduced, illustrated by several (delta) case studies. Based on that a list of 10 generic key issues and possible solutions is presented in order to further develop and support a (generic) approach how to deal with subsidence in current and future subsidence-prone areas. For exchange of experiences and knowledge development.on subsidence in deltas the Delta Alliance, a knowledge network of deltas worldwide, can be supportive.

  15. Governance of ‘long term delta planning’ in Bangladesh, Vietnam and the Netherlands

    NARCIS (Netherlands)

    Staveren, van M.F.

    2014-01-01

    The Deltas in Times of Climate Change Conference II, taking place in September 2014, Rotterdam, presented a suitable occasion to discuss both delta challenges and interesting approaches to how ‘delta dynamics’ are being dealt with worldwide.1 Delta dynamics include here both environmental (including

  16. Identifying environmental controls on the shoreline of a natural river delta

    NARCIS (Netherlands)

    Geleynse, N.; Hiatt, M.; Sangireddy, H.; Passalacqua, P.

    River deltas form where sediment-laden water debouches into a basin. The spatial delineation of a delta is nontrivial and yet is fundamental to systematically evaluating fluxes across its surface. Here we study shoreline dynamics of the Wax Lake Delta (WLD), a naturally developing delta, downstream

  17. Identifying environmental controls on the shoreline of a natural river delta

    NARCIS (Netherlands)

    Geleynse, N.; Hiatt, M.; Sangireddy, H.; Passalacqua, P.

    2015-01-01

    River deltas form where sediment-laden water debouches into a basin. The spatial delineation of a delta is nontrivial and yet is fundamental to systematically evaluating fluxes across its surface. Here we study shoreline dynamics of the Wax Lake Delta (WLD), a naturally developing delta, downstream

  18. Secondary metabolites: applications on cultural heritage.

    Science.gov (United States)

    Sasso, S; Scrano, L; Bonomo, M G; Salzano, G; Bufo, S A

    2013-01-01

    Biological sciences and related bio-technology play a very important role in research projects concerning protection and preservation of cultural heritage for future generations. In this work secondary metabolites of Burkholderia gladioli pv. agaricicola (Bga) ICMP 11096 strain and crude extract of glycoalkaloids from Solanaceae plants, were tested against a panel of microorganisms isolated from calcarenite stones of two historical bridges located in Potenza and in Campomaggiore (Southern Italy). The isolated bacteria belong to Bacillus cereus and Arthrobacter agilis species, while fungi belong to Aspergillus, Penicillium, Coprinellus, Fusarium, Rhizoctonio and Stemphylium genera. Bga broth (unfiltered) and glycoalkaloids extracts were able to inhibit the growth of all bacterial isolates. Bga culture was active against fungal colonies, while Solanaceae extract exerted bio-activity against Fusarium and Rhizoctonia genera.

  19. [Electrochemical reduction of pentaerythrityltetranitrate (PETN) and metabolites].

    Science.gov (United States)

    Hess, U; Brosig, H; König, G; Stoeter, M; Stalleicken, D

    2002-07-01

    The reduction-cascade of PETN is described as a combination of cyclic-voltammetric measurements and analytical results together with synthesis of PETN-metabolites; furthermore the electroreduction of pentaerythityldinitrate (PEDN) in the presence and absence of cystine as well as cystine and electrogenerated superoxide-radicalanions to elucidate the interaction of PETN with thiol-species. PETN was recognized as precursor for a initial radicalic process, followed by intermediate formation of pentaerythityltrinitratealdehyde (PENA) inside a self-reducing nitrate-system with NO as final product, which may explain its special position in comparison with other pharmaceutically applied nitratestructures. It could be proved, that a cystine-pool reacts as a selective moderator inside the reduction of PEDN without being interfered by O2.-, yielding pentaerythitylmononitrate (PEMN) meanwhile in the absence of cystine only pentaerythrite (PE) is formed.

  20. Encapsulates for Food Bioconversions and Metabolite Production

    Science.gov (United States)

    Breguet, Véronique; Vojinovic, Vojislav; Marison, Ian W.

    The control of production costs in the food industry must be very strict as a result of the relatively low added value of food products. Since a wide variety of enzymes and/or cells are employed in the food industry for starch processing, cheese making, food preservation, lipid hydrolysis and other applications, immobilization of the cells and/or enzymes has been recognized as an attractive approach to improving food processes while minimizing costs. This is due to the fact that biocatalyst immobilization allows for easier separation/purification of the product and reutilization of the biocatalyst. The advantages of the use of immobilized systems are many, and they have a special relevance in the area of food technology, especially because industrial processes using immobilized biosystems are usually characterized by lower capital/energy costs and better logistics. The main applications of immobilization, related to the major processes of food bioconversions and metabolite production, will be described and discussed in this chapter.

  1. Simulating radiation damage in {delta}-plutonium

    Energy Technology Data Exchange (ETDEWEB)

    Robinson, M. [Department of Mathematical Sciences, Loughborough University, Loughborough, LE11 3TU (United Kingdom)], E-mail: m.robinson@lboro.ac.uk; Kenny, S.D.; Smith, R. [Department of Mathematical Sciences, Loughborough University, Loughborough, LE11 3TU (United Kingdom); Storr, M.T.; McGee, E. [Atomic Weapons Establishment, Aldermaston, Reading, RG7 4PR (United Kingdom)

    2009-09-15

    Radiation events in {delta}-Pu (fcc) have been simulated in an attempt to understand the fundamental mechanisms that contribute to the Pu ageing process. The Pu interactions are modelled using a potential based on the modified embedded atom method (MEAM). The energetics of point defects have been investigated using static calculations together with molecular dynamics (MD) to simulate radiation events. All MD simulations were carried out with Pu initially in the face-centred-cubic (fcc) structure, although this is not the lowest energy configuration for the pure metal. The point defect study suggests that the mono-vacancy has the lowest formation energy (0.46 eV), with interstitial defects favouring the <100> - split orientation over occupation of the native fcc octahedral site. Displacement threshold energy calculations at room temperature give a minimum value of between 5 and 6 eV, increasing to 8-14 eV along the major crystallographic directions. Low energy collision cascades, initiated with energies in the range of 0.4-1 keV, show that the cascades form in a similar manner to other fcc metals with a vacancy rich zone at the cascade core, surrounded by isolated interstitial defects. Higher energy cascades show similar features but with occasional channelling of energetic atoms and sub-cascade branching which significantly reduces defect production. A common trait observed across all the cascades was the relatively slow annealing period, compared to cascades in other fcc metals, with simulations at energies above 5 keV requiring many 10's of picoseconds before the ballistic phase was completed.

  2. 基于Delta-s的高速果奶装箱机器人工程示范%Demonstration project of high-speed robot packing fruit milk based on the Delta-s

    Institute of Scientific and Technical Information of China (English)

    刘凤臣; 陈凯; 张良安; 尤晨; 周东; 刘黎明; 冯进友

    2011-01-01

    This paper focus on the practical application of the Delta-s robot on the fruit milk packing machine, including its system layout and functional requirements, gripper design based on Delta-S robot, software design and engineering practice. Based on the analysis of the basic design, this paper selects filling stations to make a specific analysis. The results showed that the application of the Delta-s robot on the fruit milk packing machine made a substantial increase in the level of automation and speed of packing! Which proved the application of the Delta-s robot on the industrial production line had very good prospects.%研究Delta-S机器人在果奶装箱机上的工程示范应用,包括其系统布局及功能要求及Delta-S机器人的抓取器设计、软件设计和工程实践等问题.在基本设计分析的基础上,选取装填工位做具体分析.分析结果表明,Delta-S机器人在高速果奶装箱机上的应用使得装箱自动化水平和速度都大幅提高,进一步说明Delta-S机器人在工业生产线上的应用具有很好的应用前景.

  3. Low-molecular-weight metabolite systems chemistry

    Directory of Open Access Journals (Sweden)

    Franz eHadacek

    2015-03-01

    Full Text Available Low-molecular-weight metabolites (LMWMs comprise primary or central and a plethora of intermediary or secondary metabolites, all of which are characterized by a molecular weight below 900 Dalton. The latter are especially prominent in sessile higher organisms, such as plants, corals, sponges and fungi, but are produced by all types of microbial organisms too. Common to all of these carbon molecules are oxygen, nitrogen and, to a lesser extent, sulfur, as heteroatoms. The latter can contribute as electron donators or acceptors to cellular redox chemistry and define the potential of the molecule to enter charge-transfer complexes. Furthermore, they allow LMWMs to serve as organic ligands in coordination complexes of various inorganic metals as central atoms. Especially the transition metals Fe, Cu and Mn can catalyze one electron reduction of molecular oxygen, which results in formation of free radical species and reactive follow-up reaction products. As antioxidants LMWMs can scavenge free radicals. Depending on the chemical environment, the same LMWMs can act as pro-oxidants by reducing molecular oxygen. The cellular regulation of redox homeostasis, a balance between oxidation and reduction, is still far from being understood. Charge-transfer and coordination complex formation with metals shapes LMWMs into gel-like matrices in the cytosol. The quasi-polymer structure is lost usually during the isolation procedure. In the gel state, LMWMs possess semiconductor properties. Also proteins and membranes are semiconductors. Together they can represent biotransistor components that can be part of a chemoelectrical signaling system that coordinates systems chemistry by initiating cell differentiation or tissue homeostasis, the activated and the resting cell state, when it is required. This concept is not new and dates back to Albert Szent-Györgyi.

  4. Delta isobars in relativistic mean-field models with $\\sigma$-scaled hadron masses and couplings

    CERN Document Server

    Kolomeitsev, E E; Voskresensky, D N

    2016-01-01

    We extend the relativistic mean-field models with hadron masses and meson-baryon coupling constants dependent on the scalar $\\sigma$ field, studied previously to incorporate $\\Delta(1232)$ baryons. Available empirical information is analyzed to put constraints on the couplings of $\\Delta$s with meson fields. Conditions for the appearance of $\\Delta$s are studied. We demonstrate that with inclusion of the $\\Delta$s our equations of state continue to fulfill majority of known empirical constraints including the pressure-density constraint from heavy-ion collisions, the constraint on the maximum mass of the neutron stars, the direct Urca and the gravitational-baryon mass ratio constraints.

  5. Production of unusual dispiro metabolites in Pestalotiopsis virgatula endophyte cultures

    DEFF Research Database (Denmark)

    Kesting, Julie Regitze; Olsen, Lars; Stærk, Dan;

    2011-01-01

    The endophytic fungus Pestalotiopsis virgatula, derived from the plant Terminalia chebula and previously found to produce a large excess of a single metabolite when grown in the minimal M1D medium, was induced to produce a variety of unusual metabolites by growing in potato dextrose broth medium...

  6. Fatty acid metabolites in rapidly proliferating breast cancer.

    Directory of Open Access Journals (Sweden)

    Joseph T O'Flaherty

    Full Text Available PURPOSE: Breast cancers that over-express a lipoxygenase or cyclooxygenase are associated with poor survival possibly because they overproduce metabolites that alter the cancer's malignant behaviors. However, these metabolites and behaviors have not been identified. We here identify which metabolites among those that stimulate breast cancer cell proliferation in vitro are associated with rapidly proliferating breast cancer. EXPERIMENTAL DESIGN: We used selective ion monitoring-mass spectrometry to quantify in the cancer and normal breast tissue of 27 patients metabolites that stimulate (15-, 12-, 5-hydroxy-, and 5-oxo-eicosatetraenoate, 13-hydroxy-octadecaenoate [HODE] or inhibit (prostaglandin [PG]E2 and D2 breast cancer cell proliferation. We then related their levels to each cancer's proliferation rate as defined by its Mib1 score. RESULTS: 13-HODE was the only metabolite strongly, significantly, and positively associated with Mib1 scores. It was similarly associated with aggressive grade and a key component of grade, mitosis, and also trended to be associated with lymph node metastasis. PGE2 and PGD2 trended to be negatively associated with these markers. No other metabolite in cancer and no metabolite in normal tissue had this profile of associations. CONCLUSIONS: Our data fit a model wherein the overproduction of 13-HODE by 15-lipoxygenase-1 shortens breast cancer survival by stimulating its cells to proliferate and possibly metastasize; no other oxygenase-metabolite pathway, including cyclooxygenase-PGE2/D2 pathways, uses this specific mechanism to shorten survival.

  7. UV-guided isolation of fungal metabolites by HSCCC

    DEFF Research Database (Denmark)

    Dalsgaard, P.W.; Nielsen, K.F.; Larsen, Thomas Ostenfeld

    2005-01-01

    Analytical standardised reversed phase liquid chromatography (RPLC) data can be helpful in finding a suitable solvent combination for isolation of fungal metabolites by high-speed counter current chromatography. Analysis of the distribution coefficient (K-D) of fungal metabolites in a series of b...

  8. Circulating acetaminophen metabolites are toxicokinetic biomarkers of acute liver injury.

    Science.gov (United States)

    Vliegenthart, Adb; Kimmitt, R A; Seymour, J H; Homer, N Z; Clarke, J I; Eddleston, M; Gray, A; Wood, D M; Dargan, P I; Cooper, J G; Antoine, D J; Webb, D J; Lewis, S C; Bateman, D N; Dear, J W

    2017-04-01

    Acetaminophen (paracetamol-APAP) is the most common cause of drug-induced liver injury in the Western world. Reactive metabolite production by cytochrome P450 enzymes (CYP-metabolites) causes hepatotoxicity. We explored the toxicokinetics of human circulating APAP metabolites following overdose. Plasma from patients treated with acetylcysteine (NAC) for a single APAP overdose was analyzed from discovery (n = 116) and validation (n = 150) patient cohorts. In the discovery cohort, patients who developed acute liver injury (ALI) had higher CYP-metabolites than those without ALI. Receiver operator curve (ROC) analysis demonstrated that at hospital presentation CYP-metabolites were more sensitive/specific for ALI than alanine aminotransferase (ALT) activity and APAP concentration (optimal CYP-metabolite receiver operating characteristic area under the curve (ROC-AUC): 0.91 (95% confidence interval (CI) 0.83-0.98); ALT ROC-AUC: 0.67 (0.50-0.84); APAP ROC-AUC: 0.50 (0.33-0.67)). This enhanced sensitivity/specificity was replicated in the validation cohort. Circulating CYP-metabolites stratify patients by risk of liver injury prior to starting NAC. With development, APAP metabolites have potential utility in stratified trials and for refinement of clinical decision-making. © 2016 American Society for Clinical Pharmacology and Therapeutics.

  9. Synthesis of an Albendazole Metabolite: Characterization and HPLC Determination

    Science.gov (United States)

    Mahler, Graciela; Davyt, Danilo; Gordon, Sandra; Incerti, Marcelo; Nunez, Ivana; Pezaroglo, Horacio; Scarone, Laura; Serra, Gloria; Silvera, Mauricio; Manta, Eduardo

    2008-01-01

    In this laboratory activity, students are introduced to the synthesis of an albendazole metabolite obtained by a sulfide oxidation reaction. Albendazole as well as its metabolite, albendazole sulfoxide, are used as anthelmintic drugs. The oxidation reagent is H[subscript 2]O[subscript 2] in acetic acid. The reaction is environmental friendly,…

  10. A Latex Metabolite Benefits Plant Fitness under Root Herbivore Attack

    NARCIS (Netherlands)

    Huber, M.; Epping, Janina; Schulze Gronover, C.; Fricke, Julia; Aziz, Zohra; Brillatz, Théo; Swyers, Michael; Kollner, T.G.; Vogel, H.; Hammerbacher, Almuth; Triebwasser-Freese, Daniella; Robert, Christelle A.M.; Verhoeven, K.J.F.; Preite, V.; Gershenzon, J.; Erb, M.

    2016-01-01

    Plants produce large amounts of secondary metabolites in their shoots and roots and store them in specialized secretory structures. Although secondary metabolites and their secretory structures are commonly assumed to have a defensive function, evidence that they benefit plant fitness under herbivor

  11. Leach and mold resistance of essential oil metabolites

    Science.gov (United States)

    Carol A. Clausen; Vina W. Yang

    2011-01-01

    Purified primary metabolites from essential oils were previously shown to be bioactive inhibitors of mold fungi on unleached Southern pine sapwood, either alone or in synergy with a second metabolite. This study evaluated the leachability of these compounds in Southern pine that was either dip- or vacuum-treated. Following laboratory leach tests, specimens were...

  12. Between Metabolite Relationships: an essential aspect of metabolic change.

    NARCIS (Netherlands)

    Jansen, J.J.; Szymanska, E.; Hoefsloot, H.C.J.; Jacobs, D.M.; Strassburg, K.; Smilde, A.K.

    2012-01-01

    Not only the levels of individual metabolites, but also the relations between the levels of different metabolites may indicate (experimentally induced) changes in a biological system. Component analysis methods in current ‘standard’ use for metabolomics, such as Principal Component Analysis (PCA),

  13. Natural occurrence of fungi and fungal metabolites in moldy tomatoes

    DEFF Research Database (Denmark)

    Andersen, B.; Frisvad, Jens Christian

    2004-01-01

    . extracted, and analyzed for fungal metabolites. Extracts from pure cultures were compared with extracts from the moldy tomatoes and fungal metabolite standards in two HPLC systems with DAD and FLD detection. The results showed that Penicillium tularense, Stemphylium eturmiunum. and S. cf. lycopersici were...

  14. Synthesis of an Albendazole Metabolite: Characterization and HPLC Determination

    Science.gov (United States)

    Mahler, Graciela; Davyt, Danilo; Gordon, Sandra; Incerti, Marcelo; Nunez, Ivana; Pezaroglo, Horacio; Scarone, Laura; Serra, Gloria; Silvera, Mauricio; Manta, Eduardo

    2008-01-01

    In this laboratory activity, students are introduced to the synthesis of an albendazole metabolite obtained by a sulfide oxidation reaction. Albendazole as well as its metabolite, albendazole sulfoxide, are used as anthelmintic drugs. The oxidation reagent is H[subscript 2]O[subscript 2] in acetic acid. The reaction is environmental friendly,…

  15. Architecture of a Coarse-Grained Upper Middle Cambrian Alluvial Delta Dominated by Braidplain and Gilbert-Style Delta Components

    Science.gov (United States)

    Pound, K. S.

    2014-12-01

    The ~500-m thick upper Middle Cambrian Lockett Conglomerate was deposited as part of an alluvial delta that includes Gilbert-type mega-crossbeds as well as braidplain conglomerates, and was constructed across an accretionary prism. Internal Lockett Conglomerate architecture indicates at least three phases of progradation are recorded by Gilbert-type, delta-front deposits that are separated by delta-top distributaries and/or braidplain deposits, all of which form discontinuous sheets and lenses, and record aggradation. Evaluation of sedimentary features (particle size and organization, bedding features) allows identification of eight facies within the Lockett Conglomerate; sedimentary features were used to infer transportational and depositional mechanisms. Conglomerate facies HL-1 - HL-8 were assigned to one or more of the following depositional associations: Beachface/shoreface, Deltafront, Alluvial fan, Braidplain (fluvial, unchannelized), Delta-top distributaries, and Mouth-bars. A series of Depositional Packages was identified, and mapped; integration with measured sections allowed development of a facies model for an alluvial delta in which the subaerial component is dominated by the braidplain association, and the subaqueous component by the (Gilbert-type) deltafront association as well as the delta-top distributary and mouthbar associations. Locally, the beachface association marks the transition between the subaqueous and subaerial components of the alluvial delta. Alluvial fan deposits are absent, but the rounded pebbles, cobbles and boulders with a new and distinctive provenance signature indicate derivation from a newly exposed igneous and metamorphic basement, and abrasion during transport through the fluvial (braidplain) system prior to deposition as part of the alluvial delta.

  16. A Conceptual Framework for Analyzing Deltas as Coupled Social-Ecological Systems: An example from the Amazon Delta

    Science.gov (United States)

    Brondizio, E.; Vogt, N. D.; Hetrick, S.; da Costa, S. M. F.; Anthony, E.

    2015-12-01

    At the nexus of watersheds, land, coastal areas, oceans, and human settlements, river delta regions pose specific challenges to environmental governance and sustainability. Using the Amazon Delta (AD) as our focus we reflect on the challenges created by the high degree of functional interdependencies shaping social-ecological dynamics of delta regions. The article introduces the initial design of an integrated conceptual framework to analyze delta regions as coupled social-ecological systems (SES). The first component of the framework is used to provide integrated definitions of delta regions according to a problem and/or collective action dilemma. Five different systematic components are suggested: social-economic systems, governance systems, ecosystems-resource systems, topographic-hydrological systems, and oceanic-climate systems. The second component of the framework presents a strategy for nested social ecological analysis to examine collective action situations in delta regions from local to regional and basin levels. The article provides illustrative applications of the framework to the Amazon Delta. First, it is used to define the AD region as a coupled, multi-level SES. We further proposed a definition of what we call the core SES of the AD. We then utilize the framework to diagnose an example collective action problem related to the impacts of urban growth and pollution on small-scale fishing resources. We argue that the functional interdependencies characteristic of delta regions require new approaches to understand, diagnose, and evaluate the current and future impact of social and environmental changes and potential solutions to the sustainability dilemmas characteristic of these regions.

  17. Hybrid isoprenoid secondary metabolite production in terrestrial and marine actinomycetes.

    Science.gov (United States)

    Gallagher, Kelley A; Fenical, William; Jensen, Paul R

    2010-12-01

    Terpenoids are among the most ubiquitous and diverse secondary metabolites observed in nature. Although actinomycete bacteria are one of the primary sources of microbially derived secondary metabolites, they rarely produce compounds in this biosynthetic class. The terpenoid secondary metabolites that have been discovered from actinomycetes are often in the form of biosynthetic hybrids called hybrid isoprenoids (HIs). HIs include significant structural diversity and biological activity and thus are important targets for natural product discovery. Recent screening of marine actinomycetes has led to the discovery of a new lineage that is enriched in the production of biologically active HI secondary metabolites. These strains represent a promising resource for natural product discovery and provide unique opportunities to study the evolutionary history and ecological functions of an unusual group of secondary metabolites. Copyright © 2010 Elsevier Ltd. All rights reserved.

  18. Development of cell metabolite analysis on microfluidic platform

    Institute of Scientific and Technical Information of China (English)

    Luyao Lin; Jin-Ming Lin

    2015-01-01

    abstract Cell metabolite analysis is of great interest to analytical chemists and physiologists, with some meta-bolites having been identified as important indicators of major diseases such as cancer. A high-throughput and sensitive method for drug metabolite analysis will largely promote the drug discovery industry. The basic barrier of metabolite analysis comes from the interference of complex components in cell biological system and low abundance of target substances. As a powerful tool in biosample analysis, microfluidic chip enhances the sensitivity and throughput by integrating multiple functional units into one chip. In this review, we discussed three critical steps of establishing functional microfluidic platform for cellular metabolism study. Cell in vitro culture model, on chip sample pretreatment, and microchip combined detectors were described in details and demonstrated by works in five years. And a brief summary was given to discuss the advantages as well as challenges of applying microchip method in cell metabolite and biosample analysis.

  19. Land-ocean interaction in modern delta formation and development: A case study of the Pearl River delta, China

    Institute of Scientific and Technical Information of China (English)

    李春初; 雷亚平; 何为; 戴志军

    2001-01-01

    The distinctive characteristics of the modern Pearl River delta formation and development are divided phases, diversity and imbalance in spatial and temporal. The delta was moving seaward gradually in a long period after the last Holocene glacial stage and the ancient drowned Pearl River estuary was predominated by tide. The delta was expanding quickly since fluvial force was turned to be leading status about 2500 years ago. The sediment grain size was changing longitudinally from coarser to finer. As well as the finer sediment may be reworked and redistributed shoreward by tidal current nearby the river mouth. And the fluvial-dominated delta is developed by the mutual deposition reflected in the vertical direction. According to the spatial difference of land-ocean interaction, the main body of the Pearl River delta which is the fluvial-dominated and protruding seaward is coupled with or concomitant with the estuaries and tide-dominated deltas which are adjoined to both sides of the main part like two wi

  20. Individual protein balance strongly influences delta15N and delta13C values in Nile tilapia, Oreochromis niloticus.

    Science.gov (United States)

    Gaye-Siessegger, Julia; Focken, Ulfert; Abel, Hansjörg; Becker, Klaus

    2004-02-01

    Although stable isotope ratios in animals have often been used as indicators of the trophic level and for the back-calculation of diets, few experiments have been done under standardized laboratory conditions to investigate factors influencing delta(15)N and delta(13)C values. An experiment using Nile tilapia [ Oreochromis niloticus (L.)] was therefore carried out to test the effect of different dietary protein contents (35.4, 42.3, and 50.9%) on delta(15)N and delta(13)C values of the whole tilapia. The fish were fed the isoenergetic and isolipidic semi-synthetic diets at a relatively low level. delta(15)N and delta(13)C values of the lipid-free body did not differ between the fish fed the diets with different protein contents, but the trophic shift for N and C isotopes decreased with increasing protein accretion in the individual fish, for N from 6.5 per thousand to 4 per thousand and for C in the lipid-free body from 4 per thousand to 2.5 per thousand. This is the first study showing the strong influence of the individual protein balance to the degree to which the isotopic signature of dietary protein was modified in tissue protein of fish. The extrapolation of the trophic level or the reconstruction of the diet of an animal from stable isotope ratios without knowledge of the individual physiological condition and the feeding rate may lead to erroneous results.

  1. Mean proloculus size, delta super(13) C and delta super(18) O variations in recent benthic foraminifera from the west coast of India and their climatic implications

    Digital Repository Service at National Institute of Oceanography (India)

    Nigam, R.; Sarkar, A.

    The interrelationship between mean proloculus size (MPS), delta super(18) O and delta super(13) C vatiations in benthic foraminiferal species Rotalidium annectens and their relation with temperature (T) and salinity (S) have been studied in samples...

  2. Structure and stability of Ba(4)CaCu(3)O(8+delta) and Ba(6)CaCu(3)O(10+delta)

    National Research Council Canada - National Science Library

    Xuan, H.Nguyen; Bertrand, Christiane; Beauquis, Sandrine; PISCH, Alexander; Soubeyroux, Jean-Louis; Galez, Philippe

    2006-01-01

    The crystal structure and thermal stability of Ba(4)CaCu(3)O(8+delta) and Ba(6)CaCu(3)O(10+delta) has been investigated by neutron powder diffration, differential thermal analysis and thermogravimetry...

  3. Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets

    DEFF Research Database (Denmark)

    Adriaenssens, Alice E; Svendsen, Berit; Lam, Brian Y H;

    2016-01-01

    and delta cells. METHODS: Sst-Cre mice crossed with fluorescent reporters were used to identify delta cells, while Glu-Venus (with Venus reported under the control of the Glu [also known as Gcg] promoter) mice were used to identify alpha and beta cells. Alpha, beta and delta cells were purified using flow...... cytometry and analysed by RNA sequencing. The role of the ghrelin receptor was validated by imaging delta cell calcium concentrations using islets with delta cell restricted expression of the calcium reporter GCaMP3, and in perfused mouse pancreases. RESULTS: A database was constructed of all genes...... expressed in alpha, beta and delta cells. The gene encoding the ghrelin receptor, Ghsr, was highlighted as being highly expressed and enriched in delta cells. Activation of the ghrelin receptor raised cytosolic calcium levels in primary pancreatic delta cells and enhanced somatostatin secretion in perfused...

  4. Urinary pesticide metabolites in school students from northern Thailand.

    Science.gov (United States)

    Panuwet, Parinya; Prapamontol, Tippawan; Chantara, Somporn; Barr, Dana B

    2009-05-01

    We evaluated exposure to pesticides among secondary school students aged 12-13 years old in Chiang Mai Province, Thailand. Pesticide-specific urinary metabolites were used as biomarkers of exposure for a variety of pesticides, including organophosphorus insecticides, synthetic pyrethroid insecticides and selected herbicides. We employed a simple solid-phase extraction with analysis using isotope dilution high-performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS). A total of 207 urine samples from Thai students were analyzed for 18 specific pesticide metabolites. We found 14 metabolites in the urine samples tested; seven of them were detected with a frequency > or=17%. The most frequently detected metabolites were 2-[(dimethoxyphosphorothioyl) sulfanyl] succinic acid (malathion dicarboxylic acid), para-nitrophenol (PNP), 3,5,6-trichloro-2-pyridinol (TPCY; metabolite of chlorpyrifos), 2,4-dichlorophenoxyacetic acid (2,4-D), cis- and trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane-1-carboxylic acids (c-DCCA and t-DCCA; metabolite of permethrin) and 3-phenoxybenzoic acid (3-PBA; metabolite of pyrethroids). The students were classified into 4 groups according to their parental occupations: farmers (N=60), merchants and traders (N=39), government and company employees (N=52), and laborers (N=56). Children of farmers had significantly higher urinary concentrations of pyrethroid insecticide metabolites than did other children (p<0.05). Similarly, children of agricultural families had significantly higher pyrethroid metabolite concentrations. Males had significantly higher values of PNP (Mann-Whitney test, p=0.009); however, no other sex-related differences were observed. Because parental occupation and agricultural activities seemed to have little influence on pesticide levels, dietary sources were the likely contributors to the metabolite levels observed.

  5. Identification of metabolites with anticancer properties by computational metabolomics

    Directory of Open Access Journals (Sweden)

    Bowen Nathan J

    2008-06-01

    Full Text Available Abstract Background Certain endogenous metabolites can influence the rate of cancer cell growth. For example, diacylglycerol, ceramides and sphingosine, NAD+ and arginine exert this effect by acting as signaling molecules, while carrying out other important cellular functions. Metabolites can also be involved in the control of cell proliferation by directly regulating gene expression in ways that are signaling pathway-independent, e.g. by direct activation of transcription factors or by inducing epigenetic processes. The fact that metabolites can affect the cancer process on so many levels suggests that the change in concentration of some metabolites that occurs in cancer cells could have an active role in the progress of the disease. Results CoMet, a fully automated Computational Metabolomics method to predict changes in metabolite levels in cancer cells compared to normal references has been developed and applied to Jurkat T leukemia cells with the goal of testing the following hypothesis: Up or down regulation in cancer cells of the expression of genes encoding for metabolic enzymes leads to changes in intracellular metabolite concentrations that contribute to disease progression. All nine metabolites predicted to be lowered in Jurkat cells with respect to lymphoblasts that were examined (riboflavin, tryptamine, 3-sulfino-L-alanine, menaquinone, dehydroepiandrosterone, α-hydroxystearic acid, hydroxyacetone, seleno-L-methionine and 5,6-dimethylbenzimidazole, exhibited antiproliferative activity that has not been reported before, while only two (bilirubin and androsterone of the eleven tested metabolites predicted to be increased or unchanged in Jurkat cells displayed significant antiproliferative activity. Conclusion These results: a demonstrate that CoMet is a valuable method to identify potential compounds for experimental validation, b indicate that cancer cell metabolism may be regulated to reduce the intracellular concentration of

  6. Initial isotopic geochemistry ({delta} 18 O, {delta} D) of fluids from wells of the Los Humeros, Pue., geothermal field; Geoquimica isotopica ({delta} 18 O, {delta} D) inicial de fluidos de pozos del campo geotermico de Los Humeros, Pue.

    Energy Technology Data Exchange (ETDEWEB)

    Barragan Reyes, Rosa Maria; Arellano Gomez, Victor Manuel [Instituto de Investigaciones Electricas, Gerencia de Geotermia, Cuernavaca, Morelos (Mexico)]. E-mail: rmb@iie.org.mx; Ramirez Montes, Miguel; Tovar Aguado, Rigoberto [Comision Federal de Electricidad, Gerencia de Proyectos Geotermoelectricos, Morelia, Michoacan (Mexico)

    2010-01-15

    Isotopic data ({delta} 18 O, {delta} D) from fluids from production wells at the Los Humeros, Pue., geothermal field were analyzed to investigate the possible origin of these fluids and the dominant processes of the reservoir at its initial state. According to pre-exploitation data, it is suggested the Los Humeros reservoir fluids are made of a mixture of meteoric water of very light isotopic composition (paleo-fluids) and andesitic water. The relationship {delta} D vs {delta} 18 O from pre-exploitation data indicates the produced fluids are composed of a mixture of (at least) two fluids with distinct isotopic compositions. At the more enriched end of the mixing relationship are the isotopic compositions of the wells H-23 and H-18 (located in the southern area of the field), while the lighter fluids were found in well H-16 (originally) and then in well H-16 (repaired). It was found that the liquid phases of deep wells are more enriched in {delta} 18 O while the shallow wells present lower values, suggesting a convection process at the initial state. Based on this isotopic profile, it is considered that even the production depths of the wells H-1, H-12 and H-16 (repaired) are just about the same, but their respective isotopic compositions are quite different. The {delta} 18 O value for well H-16 (repaired) seems to be that of condensate steam, while the corresponding values for wells H-1 and H-12 fall within the value interval of the deep wells (H-23). This suggests wells H-1 and H-12 are collecting very deep fluids enriched in {delta} 18 O. These results could be useful in creating a conceptual model of the reservoir. [Spanish] Se analizaron datos isotopicos ({delta}18 O, {delta}D) de los fluidos de pozos productores del campo geotermico de Los Humeros, Pue., para investigar el posible origen de los fluidos asi como los procesos dominantes del yacimiento en su estado inicial. De acuerdo con datos previos a la explotacion, se plantea que los fluidos del yacimiento

  7. Profile and behavior of antiviral drugs in aquatic environments of the Pearl River Delta, China.

    Science.gov (United States)

    Peng, Xianzhi; Wang, Chunwei; Zhang, Kun; Wang, Zhifang; Huang, Qiuxin; Yu, Yiyi; Ou, Weihui

    2014-01-01

    Occurrence and behavior of six antiviral pharmaceuticals (acyclovir, ganciclovir, oseltamivir, ribavirin, stavudine and zidovudine) and one active metabolite oseltamivir carboxylate were investigated in wastewater, landfill leachate, river water, reservoir and well water in the vicinity of municipal landfills in the Pearl River Delta, China. Acyclovir was the only antiviral detected in the wastewater at 177-406 (mean=238) and 114-205 (mean=154) ng L(-1) in the influent and final effluent, respectively. Aerobic biodegradation appeared to be the main process for the elimination of acyclovir in the wastewater. Acyclovir was also the only antiviral quantitatively detected in the Pearl River and its tributaries, with a maximum concentration up to 113 ng L(-1). Treated wastewater was a major source of acyclovir in the rivers. The highest concentration of acyclovir was observed in winter in the river water and the dilution effect by precipitation was suggested to be the dominant factor impacting the seasonal pattern of acyclovir in the rivers. No antivirals were quantitatively detected in the well water whereas acyclovir was frequently detected in the reservoirs at a maximal concentration of 33.6 ng L(-1) in the vicinity of the municipal landfills. However, source identification and fate of acyclovir in the reservoirs pend on further research.

  8. Passive inhalation of marijuana smoke: urinalysis and room air levels of delta-9-tetrahydrocannabinol

    Energy Technology Data Exchange (ETDEWEB)

    Cone, E.J.; Johnson, R.E.; Darwin, W.D.; Yousefnejad, D.; Mell, L.D.; Paul, B.D.; Mitchell, J.

    1987-05-01

    In two separate studies, 5 drug-free male volunteers with a history of marijuana use were passively exposed to the sidestream smoke of 4 and 16 marijuana cigarettes (2.8% delta-9-tetrahydrocannabinol (THC)) for 1 h each day for 6 consecutive days. A third study was similarly performed with 2 marijuana-naive subjects passively exposed to the smoke of 16 marijuana cigarettes. Passive smoke exposure was conducted in a small, unventilated room. Room air levels of THC and CO were monitored frequently. All urine specimens were collected and analyzed by EMIT d.a.u. assay, Abuscreen radioimmunoassay and GC/MS. The studies show that significant amounts of THC were absorbed by all subjects at the higher level of passive smoke exposure (eg., smoke from 16 marijuana cigarettes), resulting in urinary excretion of significant amounts of cannabinoid metabolites. However, it seems improbable that subjects would unknowingly tolerate the noxious smoke conditions produced by this exposure. At the lower level of passive marijuana-smoke exposure, specimens tested positive only infrequently or were negative. Room air levels of THC during passive smoke exposure appeared to be the most critical factor in determining whether a subject produced cannabinoid-positive urine specimens.

  9. Structural Insights into Clostridium perfringens Delta Toxin Pore Formation.

    Science.gov (United States)

    Huyet, Jessica; Naylor, Claire E; Savva, Christos G; Gibert, Maryse; Popoff, Michel R; Basak, Ajit K

    2013-01-01

    Clostridium perfringens Delta toxin is one of the three hemolysin-like proteins produced by C. perfringens type C and possibly type B strains. One of the others, NetB, has been shown to be the major cause of Avian Nectrotic Enteritis, which following the reduction in use of antibiotics as growth promoters, has become an emerging disease of industrial poultry. Delta toxin itself is cytotoxic to the wide range of human and animal macrophages and platelets that present GM2 ganglioside on their membranes. It has sequence similarity with Staphylococcus aureus β-pore forming toxins and is expected to heptamerize and form pores in the lipid bilayer of host cell membranes. Nevertheless, its exact mode of action remains undetermined. Here we report the 2.4 Å crystal structure of monomeric Delta toxin. The superposition of this structure with the structure of the phospholipid-bound F component of S. aureus leucocidin (LukF) revealed that the glycerol molecules bound to Delta toxin and the phospholipids in LukF are accommodated in the same hydrophobic clefts, corresponding to where the toxin is expected to latch onto the membrane, though the binding sites show significant differences. From structure-based sequence alignment with the known structure of staphylococcal α-hemolysin, a model of the Delta toxin pore form has been built. Using electron microscopy, we have validated our model and characterized the Delta toxin pore on liposomes. These results highlight both similarities and differences in the mechanism of Delta toxin (and by extension NetB) cytotoxicity from that of the staphylococcal pore-forming toxins.

  10. Factors of soil diversity in the Batumi delta (Georgia)

    Science.gov (United States)

    Turgut, Bülent; Ateş, Merve

    2017-01-01

    The aim of this study was to determine certain basic properties of soils in the Batumi delta (southwestern Georgia) to determine the relationships of studied properties and to identify differences with regards to these properties between different sampling sites in the delta that were selected based on the delta morphology. In this context, a total of 125 soil samples were collected from five different sampling sites, and the clay, silt and sand content of the samples were determined along with their mean weight diameter (MWD) values, aggregate stability (AS) values, amount of water retained under -33 (FC) and -1500 kPa (WP) pressure and organic matter (OM) content. Correlation analysis indicated that clay content and OM were positively correlated with MWD, and OM was positively correlated with AS. However, the sand content was found to be negatively correlated with MWD. In addition, clay, silt and OM content were positive correlated with FC and WP. Variance analysis results determined statistically significant differences between the sampling sites with respect to all of the evaluated properties. The active delta section of the study area was characterized by high sand content, while the lower delta plain was characterized by high OM and AS values, and the upper delta plain was characterized by high MWD values, high FC and WP moisture content levels and high clay and silt content. In conclusion, it was demonstrated that the examined properties were significantly affected by the different morphological positions and usages of these different areas. These results may help with the management of agricultural lands in the Batumi delta, which has never been studied before.

  11. Anadromous salmonids in the Delta: New science 2006–2016

    Science.gov (United States)

    Perry, Russell W.; Buchanan, Rebecca A.; Brandes, Patricia L.; Burau, Jon R.; Israel, Joshua A

    2016-01-01

    As juvenile salmon enter the Sacramento–SanJoaquin River Delta (“the Delta”) they disperse among its complex channel network where they are subject to channel-specific processes that affect their rate of migration, vulnerability to predation, feeding success, growth rates, and ultimately, survival. In the decades before 2006, tools available to quantify growth, dispersal, and survival of juvenile salmon in this complex channel network were limited.Fortunately, thanks to technological advances such as acoustic telemetry and chemical and structural otolith analysis, much has been learned over the past decade about the role of the Delta in the life cycle of juvenile salmon. Here, we review new science between 2006and 2016 that sheds light on how different life stages and runs of juvenile salmon grow, move, and survive in the complex channel network of the Delta. One of the most important advances during the past decade has been the widespread adoption of acoustic telemetry techniques. Use of telemetry has shed light on how survival varies among alternative migration routes and the proportion of fish that use each migration route. Chemical and structural analysis of otoliths has provided insights about when juveniles left their natal river and provided evidence of extended rearing in the brackish or saltwater regions of the Delta. New advancements in genetics now allow individuals captured by trawls to be assigned to specific runs. Detailed information about movement and survival in the Delta has spurred development of agent-based models of juvenile salmon that are coupled to hydrodynamic models. Although much has been learned, knowledge gaps remain about how very small juvenile salmon (fry and parr) use the Delta. Understanding how all life stages of juvenile salmon grow, rear, and survive in the Delta is critical for devising management strategies that support a diversity of life history strategies.

  12. Characterizing protein modifications by reactive metabolites using magnetic bead bioreactors and LC-MS/MS.

    Science.gov (United States)

    Li, Dandan; Fu, You-Jun; Rusling, James F

    2015-03-18

    We report here label-free metabolite-protein adduct detection and identification employing magnetic beads coated with metabolic enzymes as bioreactors to generate metabolites and possible metabolite-protein adducts for analysis by liquid chromatography-tandem mass spectrometry.

  13. Challenges and Approaches in Delta Planning and Management - Sharing experiences from SE Asian Deltas and the Rhine-Meuse Delta -Report on Regional Training Workshop

    NARCIS (Netherlands)

    Long Phi, H.; Fida Abdullah Khan, M.; Wosten, J.H.M.; Douven, W.

    2014-01-01

    The training workshop consisted of a balanced mix of lectures on specific delta topics, work on group assignments, group and plenary discussions, and group presentations. Due to high professional level of the participants the discussions often reached the level of a policy dialogue among equals rath

  14. Hydrology and morphology of two river mouth regions (temperate Vistula Delta and subtropical Red River Delta

    Directory of Open Access Journals (Sweden)

    Zbigniew Pruszak

    2005-09-01

    Full Text Available The paper presents a comparative analysis of two different river mouths from two different geographical zones (subtropical and temperate climatic regions. One is the multi-branch and multi-spit mouth of the Red River on the Gulf of Tonkin (Vietnam, the other is the smaller delta of the river Vistula on a bay of the Baltic Sea (Poland. The analysis focuses on the similarities and differences in the hydrodynamics between these estuaries and the adjacent coastal zones, the features of sediment transport, and the long-term morphodynamics of the river outlets. Salinity and water level are also discussed, the latter also in the context of the anticipated global effect of accelerated sea level rise. The analysis shows that the climatic and environmental conditions associated with geographical zones give rise to fundamental differences in the generation and dynamic evolution of the river mouths.

  15. Vortex Breakdown over Slender Delta Wings (Eclatement tourbillonnaire sur les ailes delta effil es)

    Science.gov (United States)

    2009-11-01

    Velocity Component VB 21-33 A.4 Tangential Velocity Component WB 21-34 A.5 Axial Velocity Induced on the Centreline 21-34 A.6 Numerical...Three Dimensional Vortex Sheet Structure on Delta Wings,” AGARD-CP-438, October 1988. [59] Brandon, J.M. and Shah , G.H., “Effect of Large Amplitude...TR-AVT-080 5 - 25 403020100-10-20-30-40 0.2 0.3 0.4 0.5 0.6 0.7 0.8 0.9 dynamic Static ( σ=30°, ∆φ=33°, =0.14 )k φ° x VB 15c15c 403020100-10

  16. Preparing the Dutch delta for future droughts: model based support in the national Delta Programme

    Science.gov (United States)

    ter Maat, Judith; Haasnoot, Marjolijn; van der Vat, Marnix; Hunink, Joachim; Prinsen, Geert; Visser, Martijn

    2014-05-01

    Keywords: uncertainty, policymaking, adaptive policies, fresh water management, droughts, Netherlands, Dutch Deltaprogramme, physically-based complex model, theory-motivated meta-model To prepare the Dutch Delta for future droughts and water scarcity, a nation-wide 4-year project, called Delta Programme, is established to assess impacts of climate scenarios and socio-economic developments and to explore policy options. The results should contribute to a national adaptive plan that is able to adapt to future uncertain conditions, if necessary. For this purpose, we followed a model-based step-wise approach, wherein both physically-based complex models and theory-motivated meta-models were used. First step (2010-2011) was to make a quantitative problem description. This involved a sensitivity analysis of the water system for drought situations under current and future conditions. The comprehensive Dutch national hydrological instrument was used for this purpose and further developed. Secondly (2011-2012) our main focus was on making an inventory of potential actions together with stakeholders. We assessed efficacy, sell-by date of actions, and reassessed vulnerabilities and opportunities for the future water supply system if actions were (not) taken. A rapid assessment meta-model was made based on the complex model. The effects of all potential measures were included in the tool. Thirdly (2012-2013), with support of the rapid assessment model, we assessed the efficacy of policy actions over time for an ensemble of possible futures including sea level rise and climate and land use change. Last step (2013-2014) involves the selection of preferred actions from a set of promising actions that meet the defined objectives. These actions are all modeled and evaluated using the complex model. The outcome of the process will be an adaptive management plan. The adaptive plan describes a set of preferred policy pathways - sequences of policy actions - to achieve targets under

  17. Hepatitis delta virus: protein composition of delta antigen and its hepatitis B virus-derived envelope.

    Science.gov (United States)

    Bonino, F; Heermann, K H; Rizzetto, M; Gerlich, W H

    1986-01-01

    Hepatitis delta virus (HDV)-associated particles were purified from the serum of an experimentally infected chimpanzee by size chromatography and by density centrifugation. Hepatitis delta antigen (HDAg) was detected after mild detergent treatment at a column elution volume corresponding to 36-nm particles and banded at a density of 1.25 g/ml. The serum had an estimated titer of 10(9) to 10(10) HDV-associated particles and had only a 10-fold excess of hepatitis B surface antigen (HBsAg) not associated with HDAg. Therefore, HDV appears to be much more efficiently packed and secreted than is its helper virus, hepatitis B virus (HBV), which is usually accompanied by a 1,000-fold excess of HBsAg. The protein compositions of the HDAg-containing particles were analyzed by immunoblotting with HDAg-, HBsAg-, and hepatitis B core antigen-specific antisera and monoclonal antibodies to HBV surface gene products. The HBsAg envelope of HDAg contained approximately 95% P24/GP27s, 5% GP33/36s, and 1% P39/GP42s proteins. This protein composition was more similar to that of the 22-nm particles of HBsAg than to that of complete HBV. The significant amount of GP33/36s suggests that the HBsAg component of the HDV-associated particle carries the albumin receptor. Two proteins of 27 and 29 kilodaltons which specifically bound antibody to HDAg but not HBV-specific antibodies were detected in the interior of the 36-nm particle. Since these proteins were structural components of HDAg and were most likely coded for by HDV, they were designated P27d and P29d. Images PMID:3701932

  18. DeltaA/DeltaD regulate multiple and temporally distinct phases of notch signaling during dopaminergic neurogenesis in zebrafish.

    Science.gov (United States)

    Mahler, Julia; Filippi, Alida; Driever, Wolfgang

    2010-12-08

    Dopaminergic neurons develop at distinct anatomical sites to form some of the major neuromodulatory systems in the vertebrate brain. Despite their relevance in neurodegenerative diseases and the interests in reconstitutive therapies from stem cells, mechanisms of the neurogenic switch from precursor populations to dopaminergic neurons are not well understood. Here, we investigated neurogenesis of different dopaminergic and noradrenergic neuron populations in the zebrafish embryo. Birth-dating analysis by EdU (5-ethynyl-2'-deoxyuridine) incorporation revealed temporal dynamics of catecholaminergic neurogenesis. Analysis of Notch signaling mutants and stage-specific pharmacological inhibition of Notch processing revealed that dopaminergic neurons form by temporally distinct mechanisms: dopaminergic neurons of the posterior tuberculum derive directly from neural plate cells during primary neurogenesis, whereas other dopaminergic groups form in continuous or wavelike neurogenesis phases from proliferating precursor pools. Systematic analysis of Notch ligands revealed that the two zebrafish co-orthologs of mammalian Delta1, DeltaA and DeltaD, control the neurogenic switch of all early developing dopaminergic neurons in a partially redundant manner. DeltaA/D may also be involved in maintenance of dopaminergic precursor pools, as olig2 expression in ventral diencephalic dopaminergic precursors is affected in dla/dld mutants. DeltaA/D act upstream of sim1a and otpa during dopaminergic specification. However, despite the fact that both dopaminergic and corticotropin-releasing hormone neurons derive from sim1a- and otpa-expressing precursors, DeltaA/D does not act as a lineage switch between these two neuronal types. Rather, DeltaA/D limits the size of the sim1a- and otpa-expressing precursor pool from which dopaminergic neurons differentiate.

  19. Large infrequently operated river diversions for Mississippi delta restoration

    Science.gov (United States)

    Day, John W.; Lane, Robert R.; D'Elia, Christopher F.; Wiegman, Adrian R. H.; Rutherford, Jeffrey S.; Shaffer, Gary P.; Brantley, Christopher G.; Kemp, G. Paul

    2016-12-01

    Currently the Mississippi delta stands as a highly degraded and threatened coastal ecosystem having lost about 25% of coastal wetlands during the 20th century. To address this problem, a 50 billion, 50-year restoration program is underway. A central component of this program is reintroduction of river water back into the deltaic plain to mimic natural functioning of the delta. However, opposition to diversions has developed based on a number of perceived threats. These include over-freshening of coastal estuaries, displacement of fisheries, perceived water quality problems, and assertions that nutrients in river water leads to wetland deterioration. In addition, growing climate impacts and increasing scarcity and cost of energy will make coastal restoration more challenging and limit restoration options. We address these issues in the context of an analysis of natural and artificial diversions, crevasse splays, and small sub-delta lobes. We suggest that episodic large diversions and crevasses (>5000 m3 s-1) can build land quickly while having transient impacts on the estuarine system. Small diversions (water level stress. We use land building rates for different sized diversions and impacts of large periodic inputs of river water to coastal systems in the Mississippi delta to conclude that high discharge diversions operated episodically will lead to rapid coastal restoration and alleviate concerns about diversions. Single diversion events have deposited sediments up to 40 cm in depth over areas up to 130-180 km2. This approach should have broad applicability to deltas globally.

  20. ThemeDelta: Dynamic Segmentations over Temporal Topic Models.

    Science.gov (United States)

    Gad, Samah; Javed, Waqas; Ghani, Sohaib; Elmqvist, Niklas; Ewing, Tom; Hampton, Keith N; Ramakrishnan, Naren

    2015-05-01

    We present ThemeDelta, a visual analytics system for extracting and visualizing temporal trends, clustering, and reorganization in time-indexed textual datasets. ThemeDelta is supported by a dynamic temporal segmentation algorithm that integrates with topic modeling algorithms to identify change points where significant shifts in topics occur. This algorithm detects not only the clustering and associations of keywords in a time period, but also their convergence into topics (groups of keywords) that may later diverge into new groups. The visual representation of ThemeDelta uses sinuous, variable-width lines to show this evolution on a timeline, utilizing color for categories, and line width for keyword strength. We demonstrate how interaction with ThemeDelta helps capture the rise and fall of topics by analyzing archives of historical newspapers, of U.S. presidential campaign speeches, and of social messages collected through iNeighbors, a web-based social website. ThemeDelta is evaluated using a qualitative expert user study involving three researchers from rhetoric and history using the historical newspapers corpus.

  1. On the precipitation of delta phase in ALLVAC® 718Plus

    Science.gov (United States)

    Messé, O. M.; Barnard, J. S.; Pickering, E. J.; Midgley, P. A.; Rae, C. M. F.

    2014-04-01

    ALLVAC 718Plus is a new commercial superalloy derived from Inconel 718, but possessing a higher temperature capability whilst employing the same philosophy regarding the microstructure. Many articles have been published describing various heat treatments exploiting the precipitation of intermetallic phases at grain boundaries to optimize the mechanical properties over a range of testing conditions. The requirement to further improve the mechanical properties of this alloy drives our interest in the precipitation mechanism of the delta and eta phases found in this alloy. We report the presence of finely layered structures composed of two phases, delta and eta, with distinct structures and chemistries. Possible pathways to explain this precipitation in 718Plus are considered as follows: (i) the sequential formation of the delta from eta phase and (ii) the simultaneous precipitation of both eta and delta facilitated via solute rejection. Both can result in the formation of those small delta layers observed in HRSTEM. We discuss which is most likely by comparing the relative alignment of the phases by image processing and the analysis of the HRSTEM images, and propose formation mechanisms consistent with the distinctive dislocation structures observed at the interface.

  2. Analysis of Marketing of Garri in Delta State, Nigeria

    Institute of Scientific and Technical Information of China (English)

    Ebewore S O; Idoge D E

    2015-01-01

    The study examined the marketing of a cassava-based product (garri) in Delta State, Nigeria. Data was collected from 168 respondents using structured questionnaire. A multi-stage sampling procedure was employed in selecting 168 respondents from six markets in Delta State where garri is produced and marketed. Data was analyzed by the calculation of percentages, means and running of regression. The study revealed that the marketing of garri in Delta State was predominantly a female activity. The study also revealed that the garri was marketed in three channels and that 46.4% were retailers. The study further revealed a reasonable degree of freedom of entry and exit in the garri business in Delta State. Each trader or marketer was able to earn an average profit margin of N2 190.00 (for garri marketers), while the marketing margins for garri was 13.1%. Although the marketers were faced with some challenges the average profit per marketer per month was reasonably high (N40 722). The study further showed that the socio-economic characteristics of the marketers to a large extent had a positive influence on the quantity of garri sold in the study area. From the findings it was recommended that storage facilities, extension services and good road network among others should be provided to improve the marketing of garri in Delta State, Nigeria.

  3. The case for selection at CCR5-Delta32.

    Directory of Open Access Journals (Sweden)

    Pardis C Sabeti

    2005-11-01

    Full Text Available The C-C chemokine receptor 5, 32 base-pair deletion (CCR5-Delta32 allele confers strong resistance to infection by the AIDS virus HIV. Previous studies have suggested that CCR5-Delta32 arose within the past 1,000 y and rose to its present high frequency (5%-14% in Europe as a result of strong positive selection, perhaps by such selective agents as the bubonic plague or smallpox during the Middle Ages. This hypothesis was based on several lines of evidence, including the absence of the allele outside of Europe and long-range linkage disequilibrium at the locus. We reevaluated this evidence with the benefit of much denser genetic maps and extensive control data. We find that the pattern of genetic variation at CCR5-Delta32 does not stand out as exceptional relative to other loci across the genome. Moreover using newer genetic maps, we estimated that the CCR5-Delta32 allele is likely to have arisen more than 5,000 y ago. While such results can not rule out the possibility that some selection may have occurred at C-C chemokine receptor 5 (CCR5, they imply that the pattern of genetic variation seen at CCR5-Delta32 is consistent with neutral evolution. More broadly, the results have general implications for the design of future studies to detect the signs of positive selection in the human genome.

  4. The case for selection at CCR5-Delta32.

    Directory of Open Access Journals (Sweden)

    2005-11-01

    Full Text Available The C-C chemokine receptor 5, 32 base-pair deletion (CCR5-Delta32 allele confers strong resistance to infection by the AIDS virus HIV. Previous studies have suggested that CCR5-Delta32 arose within the past 1,000 y and rose to its present high frequency (5%-14% in Europe as a result of strong positive selection, perhaps by such selective agents as the bubonic plague or smallpox during the Middle Ages. This hypothesis was based on several lines of evidence, including the absence of the allele outside of Europe and long-range linkage disequilibrium at the locus. We reevaluated this evidence with the benefit of much denser genetic maps and extensive control data. We find that the pattern of genetic variation at CCR5-Delta32 does not stand out as exceptional relative to other loci across the genome. Moreover using newer genetic maps, we estimated that the CCR5-Delta32 allele is likely to have arisen more than 5,000 y ago. While such results can not rule out the possibility that some selection may have occurred at C-C chemokine receptor 5 (CCR5, they imply that the pattern of genetic variation seen atCCR5-Delta32 is consistent with neutral evolution. More broadly, the results have general implications for the design of future studies to detect the signs of positive selection in the human genome.

  5. Using Molecular Networking for Microbial Secondary Metabolite Bioprospecting

    Directory of Open Access Journals (Sweden)

    Kevin Purves

    2016-01-01

    Full Text Available The oceans represent an understudied resource for the isolation of bacteria with the potential to produce novel secondary metabolites. In particular, actinomyces are well known to produce chemically diverse metabolites with a wide range of biological activities. This study characterised spore-forming bacteria from both Scottish and Antarctic sediments to assess the influence of isolation location on secondary metabolite production. Due to the selective isolation method used, all 85 isolates belonged to the phyla Firmicutes and Actinobacteria, with the majority of isolates belonging to the genera Bacillus and Streptomyces. Based on morphology, thirty-eight isolates were chosen for chemical investigation. Molecular networking based on chemical profiles (HR-MS/MS of fermentation extracts was used to compare complex metabolite extracts. The results revealed 40% and 42% of parent ions were produced by Antarctic and Scottish isolated bacteria, respectively, and only 8% of networked metabolites were shared between these locations, implying a high degree of biogeographic influence upon secondary metabolite production. The resulting molecular network contained over 3500 parent ions with a mass range of m/z 149–2558 illustrating the wealth of metabolites produced. Furthermore, seven fermentation extracts showed bioactivity against epithelial colon adenocarcinoma cells, demonstrating the potential for the discovery of novel bioactive compounds from these understudied locations.

  6. Using Molecular Networking for Microbial Secondary Metabolite Bioprospecting.

    Science.gov (United States)

    Purves, Kevin; Macintyre, Lynsey; Brennan, Debra; Hreggviðsson, Guðmundur Ó; Kuttner, Eva; Ásgeirsdóttir, Margrét E; Young, Louise C; Green, David H; Edrada-Ebel, Ruangelie; Duncan, Katherine R

    2016-01-08

    The oceans represent an understudied resource for the isolation of bacteria with the potential to produce novel secondary metabolites. In particular, actinomyces are well known to produce chemically diverse metabolites with a wide range of biological activities. This study characterised spore-forming bacteria from both Scottish and Antarctic sediments to assess the influence of isolation location on secondary metabolite production. Due to the selective isolation method used, all 85 isolates belonged to the phyla Firmicutes and Actinobacteria, with the majority of isolates belonging to the genera Bacillus and Streptomyces. Based on morphology, thirty-eight isolates were chosen for chemical investigation. Molecular networking based on chemical profiles (HR-MS/MS) of fermentation extracts was used to compare complex metabolite extracts. The results revealed 40% and 42% of parent ions were produced by Antarctic and Scottish isolated bacteria, respectively, and only 8% of networked metabolites were shared between these locations, implying a high degree of biogeographic influence upon secondary metabolite production. The resulting molecular network contained over 3500 parent ions with a mass range of m/z 149-2558 illustrating the wealth of metabolites produced. Furthermore, seven fermentation extracts showed bioactivity against epithelial colon adenocarcinoma cells, demonstrating the potential for the discovery of novel bioactive compounds from these understudied locations.

  7. Antimicrobial Activity of Metabolites of Various Strains of Lactobacillus acidophilus

    Directory of Open Access Journals (Sweden)

    Hassan Pyar Ali Hassan

    2011-01-01

    Full Text Available The antimicrobial activity of metabolites of eight strains of Lactobacillus acidophilus (FTDC 2804, FTDC 0785, FTDC 8592, FTDC 1295, FTDC 4793, FTDC 4462, FTDC 0582 and FTDC 2916 against  Staphylococcus aureus (gram positive and Escherichia coli (gram negative, was examined and compared using agar well diffusion method.  Lactobacillus acidophilus was cultivated in two different types of dairy growth medium namely, full cream milk and skim milk. The results showed that the metabolites of all the eight strains had significant antimicrobial effect based on zone of inhibition results when compared to control. There was a statistically significant difference in the zone of inhibition data for Staphylococcus aureus and Escherichia coli among the metabolites of the eight strains cultivated in the two different growth medium. Certain L. acidophilus strains were more effective against  Staphylococcus aureus, while other strains were more effective against  Escherichia coli. On the other hand, the growth medium had no significant influence on the antimicrobial effect of metabolites of seven strains except  L. acidophilus FTDC 4462 against Escherichia coli. As for  Staphylococcus aureus, the growth medium only affected the antimicrobial effect of metabolite of strain  L. acidophilus FTDC 1295, but did not affect the antimicrobial effect of metabolites of the other seven strains. It can be concluded that L. acidophilus cultivated in dairy products produced metabolites with antimicrobial property, which could provide beneficial medicinal values to human.

  8. Metabolites of alectinib in human: their identification and pharmacological activity

    Directory of Open Access Journals (Sweden)

    Mika Sato-Nakai

    2017-07-01

    Full Text Available Two metabolites (M4 and M1b in plasma and four metabolites (M4, M6, M1a and M1b in faeces were detected through the human ADME study following a single oral administration of [14C]alectinib, a small-molecule anaplastic lymphoma kinase inhibitor, to healthy subjects. In the present study, M1a and M1b, which chemical structures had not been identified prior to the human ADME study, were identified as isomers of a carboxylate metabolite oxidatively cleaved at the morpholine ring. In faeces, M4 and M1b were the main metabolites, which shows that the biotransformation to M4 and M1b represents two main metabolic pathways for alectinib. In plasma, M4 was a major metabolite and M1b was a minor metabolite. The contribution to in vivo pharmacological activity of these circulating metabolites was assessed from their in vitro pharmacological activity and plasma protein binding. M4 had a similar cancer cell growth inhibitory activity and plasma protein binding to that of alectinib, suggesting its contribution to the antitumor activity of alectinib, whereas the pharmacological activity of M1b was insignificant.

  9. Secondary Metabolites from Higher Fungi: Discovery, Bioactivity, and Bioproduction

    Science.gov (United States)

    Zhong, Jian-Jiang; Xiao, Jian-Hui

    Medicinal higher fungi such as Cordyceps sinensis and Ganoderma lucidum have been used as an alternative medicine remedy to promote health and longevity for people in China and other regions of the world since ancient times. Nowadays there is an increasing public interest in the secondary metabolites of those higher fungi for discovering new drugs or lead compounds. Current research in drug discovery from medicinal higher fungi involves a multifaceted approach combining mycological, biochemical, pharmacological, metabolic, biosynthetic and molecular techniques. In recent years, many new secondary metabolites from higher fungi have been isolated and are more likely to provide lead compounds for new drug discovery, which may include chemopreventive agents possessing the bioactivity of immunomodulatory, anticancer, etc. However, numerous challenges of secondary metabolites from higher fungi are encountered including bioseparation, identification, biosynthetic metabolism, and screening model issues, etc. Commercial production of secondary metabolites from medicinal mushrooms is still limited mainly due to less information about secondary metabolism and its regulation. Strategies for enhancing secondary metabolite production by medicinal mushroom fermentation include two-stage cultivation combining liquid fermentation and static culture, two-stage dissolved oxygen control, etc. Purification of bioactive secondary metabolites, such as ganoderic acids from G. lucidum, is also very important to pharmacological study and future pharmaceutical application. This review outlines typical examples of the discovery, bioactivity, and bioproduction of secondary metabolites of higher fungi origin.

  10. Development of competitive immunoassays to hydroxyl containing fungicide metabolites.

    Science.gov (United States)

    Gough, Kevin C; Jarvis, Shila; Maddison, Ben C

    2011-01-01

    This paper describes the isolation of monoclonal antibodies and the development of competitive immunoassays to pesticide metabolites of the fungicides imazalil, carbendazim and thiabendazole. The metabolite specific hydroxyl residues were used as the reactive group with which to link the metabolite to the carrier proteins Keyhole Limpet Haemocyanin (KLH) and Bovine Serum Albumin (BSA). In each case immune responses in mice were raised and monoclonal antibodies were produced. Antibodies were developed into competitive ELISAs to the appropriate metabolite. The antibody raised to a metabolite of imazalil was optimised into a competitive ELISA format which had an assay IC50 of 7.5 μg/L and a limit of detection (LOD) of 1.1 μg/L. A single antibody isolated against the metabolite of carbendazim had assay IC50s of 3.2 and 2.7 μg/L for the metabolites of carbendazim and thiabendazole respectively with an LOD of 0.38 μg/L for both. These sensitive immunoassays may have application in the monitoring of human exposure to these fungicide residues either by occupational or non-occupational routes.

  11. Metabolomics and Cheminformatics Analysis of Antifungal Function of Plant Metabolites

    Directory of Open Access Journals (Sweden)

    Miroslava Cuperlovic-Culf

    2016-09-01

    Full Text Available Fusarium head blight (FHB, primarily caused by Fusarium graminearum, is a devastating disease of wheat. Partial resistance to FHB of several wheat cultivars includes specific metabolic responses to inoculation. Previously published studies have determined major metabolic changes induced by pathogens in resistant and susceptible plants. Functionality of the majority of these metabolites in resistance remains unknown. In this work we have made a compilation of all metabolites determined as selectively accumulated following FHB inoculation in resistant plants. Characteristics, as well as possible functions and targets of these metabolites, are investigated using cheminformatics approaches with focus on the likelihood of these metabolites acting as drug-like molecules against fungal pathogens. Results of computational analyses of binding properties of several representative metabolites to homology models of fungal proteins are presented. Theoretical analysis highlights the possibility for strong inhibitory activity of several metabolites against some major proteins in Fusarium graminearum, such as carbonic anhydrases and cytochrome P450s. Activity of several of these compounds has been experimentally confirmed in fungal growth inhibition assays. Analysis of anti-fungal properties of plant metabolites can lead to the development of more resistant wheat varieties while showing novel application of cheminformatics approaches in the analysis of plant/pathogen interactions.

  12. 10 CFR 26.133 - Cutoff levels for drugs and drug metabolites.

    Science.gov (United States)

    2010-01-01

    ... cutoff levels. Otherwise, the following cutoff levels must be used for initial testing of urine specimens... Cocaine metabolites 300 Opiate metabolites 2000 Phencyclidine (PCP) 25 Amphetamines 1000...

  13. Selected Secondary Plant Metabolites for Cancer Therapy

    Directory of Open Access Journals (Sweden)

    Simone Fulda

    2015-01-01

    Full Text Available Secondary plant metabolites reveal numerous biological activities making them attractive as resource for drug development of human diseases. As the majority of cancer drugs clinically established during the past half century is derived from nature, cancer researchers worldwide try to identify novel natural products as lead compounds for cancer therapy. Natural products are considered as promising cancer therapeutics, either as single agents or in combination protocols, to enhance the antitumor activity of additional therapeutic modalities. Most natural compounds exert pleotrophic effects and modulate various signal transduction pathways. A better understanding of the complex mechanisms of action of natural products is expected to open new perspectives in coming years for their use alone or in combination therapies in oncology. Two major strategies to identify novel drug candidates from nature are the bioactivity-guided fractionation of medicinal plant extracts to isolate cytotoxic chemicals and the identification of small molecules inhibiting specific targets in cancer cells. In the present review, we report on our own efforts to unravel the molecular modes of action of phytochemicals in cancer cells and focus on resveratrol, betulinic acid, artesunate, dicentrine and camptothecin derivatives.

  14. Glutamine and glutamate as vital metabolites

    Directory of Open Access Journals (Sweden)

    Newsholme P.

    2003-01-01

    Full Text Available Glucose is widely accepted as the primary nutrient for the maintenance and promotion of cell function. This metabolite leads to production of ATP, NADPH and precursors for the synthesis of macromolecules such as nucleic acids and phospholipids. We propose that, in addition to glucose, the 5-carbon amino acids glutamine and glutamate should be considered to be equally important for maintenance and promotion of cell function. The functions of glutamine/glutamate are many, i.e., they are substrates for protein synthesis, anabolic precursors for muscle growth, they regulate acid-base balance in the kidney, they are substrates for ureagenesis in the liver and for hepatic and renal gluconeogenesis, they act as an oxidative fuel for the intestine and cells of the immune system, provide inter-organ nitrogen transport, and act as precursors of neurotransmitter synthesis, of nucleotide and nucleic acid synthesis and of glutathione production. Many of these functions are interrelated with glucose metabolism. The specialized aspects of glutamine/glutamate metabolism of different glutamine-utilizing cells are discussed in the context of glucose requirements and cell function.

  15. Dichlorodiphenyltrichloroethane (DDT), DDT Metabolites and Pregnancy Outcomes

    Science.gov (United States)

    Kezios, Katrina L.; Liu, Xinhua; Cirillo, Piera M.; Cohn, Barbara A.; Kalantzi, Olga I.; Wang, Yunzhu; Petreas, Myrto X.; Park, June-Soo; Factor-Litvak, Pam

    2012-01-01

    Organochlorine pesticides (OCPs) are persistent endocrine disruptors. OCPs cross the placenta; this prenatal exposure has been associated with adverse pregnancy outcomes. We investigated associations between prenatal exposure to OCPs and gestational age and birth weight in 600 infants born between 1960 and 1963. The primary OCP was 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (p,p′-DDT), its primary metabolite, 1,1′-dichloro-2,2'-bis(p-chlorophenyl)ethylene(p,p′-DDE) and the contaminant, 1,1,1-trichloro-2-(p-chlorophenyl)-2-(o-chlorophenyl)-ethane (o,p′-DDT). Regression analysis indicated that for each natural log unit increase in p,p′-DDT, birth weight increased by 274 grams (95% CI 122, 425) when controlling for p,p′-DDE and o,p′-DDT. At a given level of p,p′-DDT exposure, o,p′-DDT and p,p′-DDE were associated with decreased birth weight. p,p′-DDE was negatively associated with length of gestation, controlling for p,p′-DDT and o,p′-DDT. These findings suggest opposing associations between exposure to p,p′-DDT and p,p′-DDE and birth weight. We did not find evidence to support mediation by maternal thyroid hormone status nor that the association differed by sex. PMID:23142753

  16. Dietary Metabolites and Chronic Kidney Disease

    Directory of Open Access Journals (Sweden)

    Sho Hasegawa

    2017-04-01

    Full Text Available Dietary contents and their metabolites are closely related to chronic kidney disease (CKD progression. Advanced glycated end products (AGEs are a type of uremic toxin produced by glycation. AGE accumulation is not only the result of elevated glucose levels or reduced renal clearance capacity, but it also promotes CKD progression. Indoxyl sulfate, another uremic toxin derived from amino acid metabolism, accumulates as CKD progresses and induces tubulointerstitial fibrosis and glomerular sclerosis. Specific types of amino acids (d-serine or fatty acids (palmitate are reported to be closely associated with CKD progression. Promising therapeutic targets associated with nutrition include uremic toxin absorbents and inhibitors of AGEs or the receptor for AGEs (RAGE. Probiotics and prebiotics maintain gut flora balance and also prevent CKD progression by enhancing gut barriers and reducing uremic toxin formation. Nrf2 signaling not only ameliorates oxidative stress but also reduces elevated AGE levels. Bardoxolone methyl, an Nrf2 activator and NF-κB suppressor, has been tested as a therapeutic agent, but the phase 3 clinical trial was terminated owing to the high rate of cardiovascular events. However, a phase 2 trial has been initiated in Japan, and the preliminary analysis reveals promising results without an increase in cardiovascular events.

  17. Arachidonic acid metabolites in pathogenic yeasts

    Directory of Open Access Journals (Sweden)

    Ells Ruan

    2012-08-01

    Full Text Available Abstract Although most of what is known about the biology and function of arachidonic acid metabolites comes from the study of mammalian biology, these compounds can also be produced by lower eukaryotes, including yeasts and other fungi. It is also in this group of organisms that the least is known about the metabolic pathways leading to the production of these compounds as well as the functions of these compounds in the biology of fungi and yeasts. This review will deal with the discovery of oxylipins from polyunsaturated fatty acids, and more specifically the arachidonic acid derived eicosanoids, such as 3-hydroxy eicosatetraenoic acid, prostaglandin F2α and prostaglandin E2, in yeasts starting in the early 1990s. This review will also focus on what is known about the metabolic pathways and/or proteins involved in the production of these compounds in pathogenic yeasts. The possible roles of these compounds in the biology, including the pathology, of these organisms will be discussed.

  18. Medicinal chemistry of drugs with active metabolites following conjugation.

    Science.gov (United States)

    Kalász, Huba; Petroianu, Georg; Hosztafi, Sándor; Darvas, Ferenc; Csermely, Tamás; Adeghate, Ernest; Siddiq, Afshan; Tekes, Kornélia

    2013-10-01

    Authorities of Drug Administration in the United States of America approved about 5000 drugs for use in the therapy or management of several diseases. About two hundred of these drugs have active metabolites and the knowledge of their medicinal chemistry is important both in medical practice and pharmaceutical research. This review gives a detailed description of the medicinal chemistry of drugs with active metabolites generated after conjugation. This review focused on glucuronide-, acetyl-, sulphate- and phosphate-conjugation of drugs, converting the drug into an active metabolite. This conversion essentially changed the lipophilicity of the drug.

  19. Interconvertions between delta-lactam and delta-lactone derivatives initiated by unique transannular interactions of the rigid cyclohexane boat structure in pentacycloundecane.

    Science.gov (United States)

    Kruger, Hendrik G; Martins, Frans J C; Viljoen, Agatha M

    2004-07-09

    The pentacycloundecane (PCU) cage structure resembles a perfect boat conformation, and for the first time unique lactam/lactone interconversions on the flagpole carbons of a cyclohexane boat structure are reported. The syntheses of a novel dihydroxy-PCU-delta-lactone and two novel N-substituted PCU-delta-lactams are reported. Hydrolysis of some of the PCU-delta-lactam compounds produced delta-lactones, and reaction of the lactones with ammonia or primary amines again produced delta-lactams. Reaction mechanisms to account for the unusual interconversion reactions induced by transannular interactions are proposed.

  20. Morphology of river deltas on Titan and Earth

    Science.gov (United States)

    Witek, Piotr; Czechowski, Leszek

    2016-07-01

    The Cassini-Huygens mission is entering its final phase. The landing of Huygens on Titan and flybys performed by the Cassini probe during the last ten years revolutionized our knowledge about that moon, revealing a complex fluvio-lacustrine environment. Despite significant differences in composition, temperature and gravity, the processes of sediment transport and deposition are similar on Earth and Titan. We performed numerical simulations of development of river deltas in Titanian and terrestrial conditions, under various discharges and with different dominant grain sizes. We found that evolution of deltaic deposits is more rapid on Titan due to higher efficiency of transport, but the flat, lobate river deltas may form in narrower range of parameters than on Earth. Our results help in understanding the evolution of sedimentary deposits and may partially explain the paucity of river deltas in Titan's lakes.

  1. Fluvial transport on Titan: formation and evolution of river deltas

    Science.gov (United States)

    Witek, Piotr Przemyslaw; Czechowski, Leszek

    2016-10-01

    The Cassini-Huygens mission provided numerous observations indicating that processes of sediment transport are currently operating on the surface of Titan. We performed numerical simulations of flow and sediment transport on Titan with particular emphasis on formation of sedimentary landforms in Titan's lakes. We compared the morphology and evolution of landforms formed in Titanian and terrestrial conditions, under various discharges and with different dominant grain sizes. The processes are similar in both environments; in some cases we observed bifurcation of the flow and switching of the active distributaries. Such processes may lead to abandonment of some delta lobes, as hypothesized for the delta observed in Ontario Lacus on Titan. The lower gravity of Titan and higher buoyancy of the most plausible kinds of sediment result in higher efficiency of transport and generally faster evolution of the deltaic deposits. Our results suggest also that the flat, lobate river deltas may form in narrower range of parameters than on Earth.

  2. Sliding mode control the delta-sigma modulation approach

    CERN Document Server

    Sira-Ramírez, Hebertt

    2015-01-01

    This monograph presents a novel method of sliding mode control for switch-regulated nonlinear systems. The Delta Sigma modulation approach allows one to implement a continuous control scheme using one or multiple, independent switches, thus effectively merging the available linear and nonlinear controller design techniques with sliding mode control.   Sliding Mode Control: The Delta-Sigma Modulation Approach, combines rigorous mathematical derivation of the unique features of Sliding Mode Control and Delta-Sigma modulation with numerous illustrative examples from diverse areas of engineering. In addition, engineering case studies demonstrate the applicability of the technique and the ease with which one can implement the exposed results. This book will appeal to researchers in control engineering and can be used as graduate-level textbook for a first course on sliding mode control.

  3. An analysis of nonlinear behavior in delta-sigma modulators

    Science.gov (United States)

    Ardalan, Sasan H.; Paulos, John J.

    1987-06-01

    The paper introduces a new method of analysis for delta-sigma modulators based on modeling the nonlinear quantizer with a linearized gain, obtained by minimizing a mean-square-error criterion, followed by an additive noise source representing distortion components. In the paper, input signal amplitude dependencies of delta-sigma modulator stability and signal-to-noise ratio are analyzed. It is shown that due to the nonlinearity of the quantizer, the signal-to-noise ratio of the modulator may decrease as the input amplitude increases prior to saturation. Also, a stable third-order delta-sigma modulator may become unstable by increasing the input amplitude beyond a certain threshold. Both of these phenomena are explained by the nonlinear analysis of this paper. The analysis is carried out for both dc and sinusoidal excitations.

  4. Cystic fibrosis Delta F508 heterozygotes, smoking, and reproduction

    DEFF Research Database (Denmark)

    Dahl, Morten; Tybjaerg-Hansen, A; Wittrup, H H

    1998-01-01

    Cystic fibrosis is the most common fatal autosomal recessive disease affecting Caucasian populations. It remains a puzzle how this disease is maintained at such a remarkably high incidence, however, it could be due to a reproductive advantage in cystic fibrosis heterozygotes. We tested this hypot......Cystic fibrosis is the most common fatal autosomal recessive disease affecting Caucasian populations. It remains a puzzle how this disease is maintained at such a remarkably high incidence, however, it could be due to a reproductive advantage in cystic fibrosis heterozygotes. We tested.......001). In conclusion, overall these results do not support a reproductive advantage for cystic fibrosis DeltaF508 heterozygotes. However, the data cannot totally exclude the possibility that nonsmoking DeltaF508 heterozygotes experience a reproductive advantage while smoking DeltaF508 heterozygotes experience...... the opposite, a reproductive disadvantage. Accordingly, the data suggest a previously undocumented role of smoking on fecundity among cystic fibrosis heterozygotes....

  5. Hints on the quadrupole deformation of the $\\Delta$(1232)

    CERN Document Server

    Fernandez-Ramirez, C; Udias, J M

    2006-01-01

    The E2/M1 ratio (EMR) of the $\\Delta$(1232) extracted from the world data in pion photoproduction by means of an Effective Lagrangian Approach (ELA). For the first time this quantity has been derived within a crossing symmetric, gauge invariant, and chiral symmetric Lagrangian model which also contains a consistent modern treatment of the $\\Delta$(1232) resonance. The \\textit{bare} s-channel $\\Delta$(1232) contribution is well isolated and Final State Interactions (FSI) are effectively taken into account fulfilling Watson's theorem. The obtained EMR value, EMR$=(-1.30\\pm0.52)$%, is in good agreement with the latest lattice QCD calculations [Phys. Rev. Lett. 94, 021601 (2005)] and disagrees with results of current quark model calculations.

  6. Water pollution remote sensing for Pearl River Delta

    Science.gov (United States)

    Deng, Ruru; Xiong, Shouping; Qin, Yan

    2008-10-01

    Water pollution on the Delta of Pearl River is increasingly serious and to command the fact of pollution is the key of the control. A remote sensing model for water pollution base on single scattering is deduced in this paper. To avoid the effect by turbidity of water, by analysis the characteristics of the energy composition of multiple scattering, a factor of second scattering is deduced to build a double scattering model, and the practical arithmetic for the calculation of the model is put forwarded and then used to the pollution remote sensing over the Pearl River Delta. The precision of the result is validated by the synchronous measured data on water surface. The result of remote sensing showed that all of the North River, East River and West River are polluted in Pearl River Delta, and the most serious pollution is take place around Guang Zhou City and Dong Guan City.

  7. Electroproduction of the {Delta}(1232) Resonance at High Momentum Transfer

    Energy Technology Data Exchange (ETDEWEB)

    Frolov, V.V.; Adams, G.S.; Davidson, R.M.; Klusman, M.; Mukhopadhyay, N.C.; Napolitano, J.; Nozar, M.; Price, J.W.; Stoler, P.; Witkowski, M. [Physics Department, Rensselaer Polytechnic Institute, Troy, New York 12180 (United States); Bosted, P. [Physics Department, American University, Washington, D.C. 20016 (United States); Armstrong, C.S.; Meekins, D. [Department of Physics, College of William Mary, Williamsburg, Virginia 23187 (United States); Assamagan, K.; Avery, S.; Baker, O.K.; Eden, T.; Gaskell, D.; Gueye, P.; Hinton, W.; Keppel, C.; Madey, R.; Niculescu, G.; Niculescu, I.; Tang, L. [Physics Department, Hampton University, Hampton, Virginia 23668 (United States); Ahmidouch, A.; Madey, R. [Physics Department, Kent State University, Kent, Ohio 44242 (United States); Kim, W. [Physics Department, Kyungpook National University, Taegu, South (Korea); Baker, O.K.; Burkert, V.; Carlini, R.; Dunne, J.; Ent, R.; Keppel, C.; Mack, D.; Mitchell, J.; Tang, L.; Wood, S. [Thomas Jefferson National Accelerator Facility, Newport News, Virginia 23606 (United States); Koltenuk, D. [Physics Department, University of Pennsylvania, Philadelphia, Pennsylvania 19104 (United States); Minehart, R. [Physics Department, University of Virginia, Charlottesville, Virginia 22903 (United States); Mkrtchyan, H.; Tadevosian, V. [Yerevan Physics Institute, Yerevan (Armenia)

    1999-01-01

    We studied the electroproduction of the {Delta}(1232) resonance via the reaction p(e,thinspe{sup {prime}}p){pi}{sup 0} at four-momentum transfers Q{sup 2}=2.8 and 4.0 GeV{sup 2} . This is the highest Q{sup 2} for which exclusive resonance electroproduction has ever been observed. Decay angular distributions for {Delta}{r_arrow}p{pi}{sup 0} were measured over a wide range of barycentric energies covering the resonance. The N{endash}{Delta} transition form factor G{sup {asterisk}}{sub M} and ratios of resonant multipoles E{sub 1+}/M{sub 1+} and S{sub 1+}/M{sub 1+} were extracted from the decay angular distributions. These ratios remain small, indicating that perturbative QCD is not applicable for this reaction at these momentum transfers. {copyright} {ital 1998} {ital The American Physical Society }

  8. Monitoring the urbanization of the Nile Delta, Egypt.

    Energy Technology Data Exchange (ETDEWEB)

    Sultan, M.; Fiske, M.; Stein, T.; Gamal, M.; El Araby, H.; Madani, A.; Mehanee, S.; Becker, R.; Environmental Research; Washington Univ.; Cairo Univ. Center for Environmental Hazard Mitigation

    1999-11-01

    Comparisons of satellite images of the Nile Delta, acquired in 1972, 1984 and 1990, indicate that urban growth is endangering Egypt's agricultural productivity. Urban areas occupied a minimum of 3.6%, 4.7% and 5.7% of the Delta in 1972, 1984 and 1990, respectively, an increase of 58% in 18 years. Approximately half of this increase occurred between 1984 and 1990. If this trend continues, Egypt could lose 12% of its total agricultural area to urbanization by 2010. Despite the fact that growth is pronounced around the cities, it is the growth around the thousands of small villages that poses the largest threat to the agricultural productivity of the Nile Delta. The cumulative growth rate for the cities and large villages between 1972 and 1990 is 37%, and that for the small villages is 77% for the same time period.

  9. Stable isotope deltas: Tiny, yet robust signatures in nature

    Science.gov (United States)

    Brand, Willi A.; Coplen, Tyler B.

    2012-01-01

    Although most of them are relatively small, stable isotope deltas of naturally occurring substances are robust and enable workers in anthropology, atmospheric sciences, biology, chemistry, environmental sciences, food and drug authentication, forensic science, geochemistry, geology, oceanography, and paleoclimatology to study a variety of topics. Two fundamental processes explain the stable isotope deltas measured in most terrestrial systems: isotopic fractionation and isotope mixing. Isotopic fractionation is the result of equilibrium or kinetic physicochemical processes that fractionate isotopes because of small differences in physical or chemical properties of molecular species having different isotopes. It is shown that the mixing of radioactive and stable isotope end members can be modelled to provide information on many natural processes, including 14C abundances in the modern atmosphere and the stable hydrogen and oxygen isotopic compositions of the oceans during glacial and interglacial times. The calculation of mixing fractions using isotope balance equations with isotope deltas can be substantially in error when substances with high concentrations of heavy isotopes (e.g. 13C, 2H, and 18O ) are mixed. In such cases, calculations using mole fractions are preferred as they produce accurate mixing fractions. Isotope deltas are dimensionless quantities. In the International System of Units (SI), these quantities have the unit 1 and the usual list of prefixes is not applicable. To overcome traditional limitations with expressing orders of magnitude differences in isotope deltas, we propose the term urey (symbol Ur), after Harold C. Urey, for the unit 1. In such a manner, an isotope delta value expressed traditionally as−25 per mil can be written as−25 mUr (or−2.5 cUr or−0.25 dUr; the use of any SI prefix is possible). Likewise, very small isotopic differences often expressed in per meg ‘units’ are easily included (e.g. either+0.015 ‰ or+15 per meg

  10. Structure of the [delta]-opioid receptor bound to naltrindole

    Energy Technology Data Exchange (ETDEWEB)

    Granier, Sébastien; Manglik, Aashish; Kruse, Andrew C.; Kobilka, Tong Sun; Thian, Foon Sun; Weis, William I.; Kobilka, Brian K. (Stanford-MED)

    2012-07-11

    The opioid receptor family comprises three members, the {mu}-, {delta}- and {kappa}-opioid receptors, which respond to classical opioid alkaloids such as morphine and heroin as well as to endogenous peptide ligands like endorphins. They belong to the G-protein-coupled receptor (GPCR) superfamily, and are excellent therapeutic targets for pain control. The {delta}-opioid receptor ({delta}-OR) has a role in analgesia, as well as in other neurological functions that remain poorly understood. The structures of the {mu}-OR and {kappa}-OR have recently been solved. Here we report the crystal structure of the mouse {delta}-OR, bound to the subtype-selective antagonist naltrindole. Together with the structures of the {mu}-OR and {kappa}-OR, the {delta}-OR structure provides insights into conserved elements of opioid ligand recognition while also revealing structural features associated with ligand-subtype selectivity. The binding pocket of opioid receptors can be divided into two distinct regions. Whereas the lower part of this pocket is highly conserved among opioid receptors, the upper part contains divergent residues that confer subtype selectivity. This provides a structural explanation and validation for the 'message-address' model of opioid receptor pharmacology, in which distinct 'message' (efficacy) and 'address' (selectivity) determinants are contained within a single ligand. Comparison of the address region of the {delta}-OR with other GPCRs reveals that this structural organization may be a more general phenomenon, extending to other GPCR families as well.

  11. Stable isotope deltas: tiny, yet robust signatures in nature.

    Science.gov (United States)

    Brand, Willi A; Coplen, Tyler B

    2012-09-01

    Although most of them are relatively small, stable isotope deltas of naturally occurring substances are robust and enable workers in anthropology, atmospheric sciences, biology, chemistry, environmental sciences, food and drug authentication, forensic science, geochemistry, geology, oceanography, and paleoclimatology to study a variety of topics. Two fundamental processes explain the stable isotope deltas measured in most terrestrial systems: isotopic fractionation and isotope mixing. Isotopic fractionation is the result of equilibrium or kinetic physicochemical processes that fractionate isotopes because of small differences in physical or chemical properties of molecular species having different isotopes. It is shown that the mixing of radioactive and stable isotope end members can be modelled to provide information on many natural processes, including (14)C abundances in the modern atmosphere and the stable hydrogen and oxygen isotopic compositions of the oceans during glacial and interglacial times. The calculation of mixing fractions using isotope balance equations with isotope deltas can be substantially in error when substances with high concentrations of heavy isotopes (e.g. (13)C, (2)H, and (18)O ) are mixed. In such cases, calculations using mole fractions are preferred as they produce accurate mixing fractions. Isotope deltas are dimensionless quantities. In the International System of Units (SI), these quantities have the unit 1 and the usual list of prefixes is not applicable. To overcome traditional limitations with expressing orders of magnitude differences in isotope deltas, we propose the term urey (symbol Ur), after Harold C. Urey, for the unit 1. In such a manner, an isotope delta value expressed traditionally as-25 per mil can be written as-25 mUr (or-2.5 cUr or-0.25 dUr; the use of any SI prefix is possible). Likewise, very small isotopic differences often expressed in per meg 'units' are easily included (e.g. either+0.015 ‰ or+15 per meg

  12. Salinity Impacts on Agriculture and Groundwater in Delta Regions

    Science.gov (United States)

    Clarke, D.; Salehin, M.; Jairuddin, M.; Saleh, A. F. M.; Rahman, M. M.; Parks, K. E.; Haque, M. A.; Lázár, A. N.; Payo, A.

    2015-12-01

    Delta regions are attractive for high intensity agriculture due to the availability of rich sedimentary soils and of fresh water. Many of the world's tropical deltas support high population densities which are reliant on irrigated agriculture. However environmental changes such as sea level rise, tidal inundation and reduced river flows have reduced the quantity and quality of water available for successful agriculture. Additionally, anthropogenic influences such as the over abstraction of ground water and the increased use of low quality water from river inlets has resulted in the accumulation of salts in the soils which diminishes crop productivity. Communities based in these regions are usually reliant on the same water for drinking and cooking because surface water is frequently contaminated by commercial and urban pollution. The expansion of shallow tube well systems for drinking water and agricultural use over the last few decades has resulted in mobilisation of salinity in the coastal and estuarine fringes. Sustainable development in delta regions is becoming constrained by water salinity. However salinity is often studied as an independent issue by specialists working in the fields of agriculture, community water supply and groundwater. The lack of interaction between these disciplines often results in corrective actions being applied to one sector without fully assessing the effects of these actions on other sectors. This paper describes a framework for indentifying the causes and impacts of salinity in delta regions based on the source-pathway-receptor framework. It uses examples and scenarios from the Ganges-Brahmaputra-Meghna delta in Bangladesh together with field measurements and observations made in vulnerable coastal communities. The paper demonstrates the importance of creating an holistic understanding of the development and management of water resources to reduce the impact of salinity in fresh water in delta regions.

  13. Nigeria. Petroleum, pollution and poverty in the Niger Delta

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2009-06-15

    The oil industry has operated in the Niger Delta in Nigeria for more than half a century - bringing almost no benefit to the people living there. Instead, widespread and unchecked human rights violations have pushed many people deeper into poverty and deprivation, fuelled conflict and led to a pervasive sense of powerlessness and frustration. This multidimensional crisis is driven by many factors - abuses committed by the security forces and militant groups, extensive pollution of land and water, corruption, serious corporate bad practice and government neglect. Nigeria: Petroleum, pollution and poverty in the Niger Delta focuses on one dimension of the crisis: the impact of pollution and environmental damage caused by the oil industry on the human rights of those living in the Niger Delta. Many people in the oil-producing areas of the delta rely on fisheries, subsistence agriculture and associated processing industries for their livelihood. Decades of pollution and environmental damage have resulted in violations of the right to an adequate standard of living - including food and water - violations of the right to gain a living through work, and violations of the right to health. The report examines who is responsible for this situation in a context where multinational oil companies have been operating for decades. It highlights how companies take advantage of the weak regulatory systems that characterize many poor countries, and how the poorest people are often the most vulnerable to exploitation. The people of the Niger Delta have seen their human rights undermined by oil companies that their government can not - or will not - hold to account. They have been systematically denied access to information about how oil exploration and production will affect them, and are repeatedly denied access to justice. The Niger Delta provides a stark case study of the lack of accountability of a government to the people, and of multinational companies' almost total lack

  14. Diversity of V delta-J delta gene rearrangement in peripheral blood lymphocytes and intrathecal IgG synthesis in multiple sclerosis.

    Science.gov (United States)

    Michałowska-Wender, G; Nowak, J; Losy, J; Januszkiewicz, D; Wender, M

    1999-01-01

    The object of the study is a comparison of intrathecal IgG synthesis and gamma/delta TCR genes rearrangement in multiple sclerosis. The subgroup of 13 cases with intrathecal IgG synthesis and positive oligoclonal bands was compared with 8 cases with IgG index below 0.75 and with undetectable oligoclonal bands. TCR gene rearrangement was studied in peripheral blood lymphocytes by PCR analysis. In majority of cases of the first group the V delta-J delta junctional repertoire was restricted as evidenced by oligoclonal rearrangement. Monoclonal pattern of rearrangement was also established in some cases concerning V delta 1-J delta 1 and V delta 5-J delta 1. In all cases with one exception, demonstrating IgG index < 0.75 and with negative oligoclonal bands in CSF the oligo- or polyclonal pattern of V delta-J delta gene rearrangement was noticed. It is therefore suggested that subset T and B lymphocytes may undergo clonal expansion in MS as evidenced by restricted pattern of V delta-J delta rearrangement and intrathecal oligoclonal IgG synthesis, respectively. Oligoclonal expansion at certain B and T cells may occur due to stimulation by an antigen related to MS pathogen.

  15. Transgenic expression of salmon delta-5 and delta-6 desaturase in zebrafish muscle inhibits the growth of Vibrio alginolyticus and affects fish immunomodulatory activity.

    Science.gov (United States)

    Wang, Yi-Da; Peng, Kuan-Chieh; Wu, Jen-Leih; Chen, Jyh-Yih

    2014-08-01

    Marine fish are an important nutritional source for highly polyunsaturated fatty acids (PUFAs). PUFA biosynthesis requires the following key enzymes: delta-4 (Δ-4) desaturase, delta-5 (Δ-5) desaturase, delta-6 (Δ-6) desaturase, delta-5 (Δ-5) elongase, and delta-6 (Δ-6) elongase. The effect of overexpressing delta-5 desaturase and/or delta-6 desaturase in zebrafish muscle has not previously been reported. Herein, we investigated the effects of these proteins on antibacterial and immunomodulatory activity in transgenic zebrafish infected with Vibrio alginolyticus. Overexpression of delta-5 and delta-6 desaturase enhanced antibacterial activity at 4 and 12 h after injection of bacteria into muscle, as compared to controls. Furthermore, expression of immune-related genes (IL-1β, IL-22, and TNF-α) was observed to be altered in transgenic fish after 4 h of bacterial infection, resulting in a significant decrease in the inflammatory response, as compared to control fish. These results demonstrate that muscle-specific expression of transgenic desaturases in zebrafish not only enhance PUFA production, but also enhance antibacterial and anti-inflammatory activity. Overall, these results identify delta-5 and delta-6 desaturase as novel candidate genes for use in aquaculture, to enhance both disease resistance and fish oil production.

  16. All optical asynchronous binary delta-sigma modulator

    Science.gov (United States)

    Tafazoli, M.; Davoudzadeh, N.; Sayeh, M. R.

    2013-03-01

    We present the first all optical delta-sigma modulator using a bistable device and a leaky integrator. In this paper, a novel tri-coupled ring geometry is utilized, resulting in resonance which is a building block for delta-sigma modulator. In each ring, the main active element is a semiconductor optical amplifier (SOA). The experimental result of the implemented setup is in a good agreement with our presented theory. Applying optical discrete components leads to a sampling rate of 660 kS/s. The higher frequency can be reached easily by using faster bistable devices and shorter loops.

  17. On the meaning of {Delta}T/T

    Energy Technology Data Exchange (ETDEWEB)

    Stebbins, A.

    1993-02-01

    One of the most interesting aspects of the discovery of Microwave Background Radiation (MBR) anisotropy by the COBE satellite is the ability to compare these anisotropies with the amplitude of density inhomogeneities we measure. Combining these two, we can get a ``unified`` view of the inhomogeneities present in our universe on a broad range of scales. To make this comparison we must be able to translate {Delta}T/T into {delta}p/{bar p}, the mass overdensity. This latter quantity we may try to determine from the distribution of galaxies and their velocities.

  18. On the meaning of [Delta]T/T

    Energy Technology Data Exchange (ETDEWEB)

    Stebbins, A.

    1993-02-01

    One of the most interesting aspects of the discovery of Microwave Background Radiation (MBR) anisotropy by the COBE satellite is the ability to compare these anisotropies with the amplitude of density inhomogeneities we measure. Combining these two, we can get a unified'' view of the inhomogeneities present in our universe on a broad range of scales. To make this comparison we must be able to translate [Delta]T/T into [delta]p/[bar p], the mass overdensity. This latter quantity we may try to determine from the distribution of galaxies and their velocities.

  19. {ital {Delta}I}=4 Bifurcation in Identical Superdeformed Bands

    Energy Technology Data Exchange (ETDEWEB)

    Haslip, D.; Flibotte, S.; Gervais, G.; Nieminen, J.; Svensson, C.; Waddington, J.; Wilson, J. [Department of Physics and Astronomy, McMaster University, Hamilton, Ontario, L8S 4M1 (CANADA); de France, G. [Centre de Recherches Nucleaires et ULP, F-67037 Strasbourg Cedex 2 (France); Devlin, M.; LaFosse, D.; Lerma, F.; Sarantites, D. [Chemistry Department, Washington University, St. Louis, Missouri 63130 (United States); Galindo-Uribarri, A. [AECL, Chalk River Laboratories, Chalk River, Ontario, K0J 1J0 (CANADA); Hackman, G. [Argonne National Laboratory, Argonne, Illinois 60439 (United States); Lee, I.; Macchiavelli, A.; MacLeod, R. [Nuclear Science Division, Lawrence Berkeley Laboratory, Berkeley, California 94720 (United States); Mullins, S. [Department of Nuclear Physics, RSPhysSE, ANU, Canberra, ACT 0200 (Australia)

    1997-05-01

    {Delta}I=4 bifurcation has been observed in two superdeformed bands, the newly discovered yrast superdeformed band of {sup 148}Eu, and a previously known excited band in {sup 148}Gd. Both of these bands have moments of inertia that are identical to the yrast band of {sup 149}Gd, the first superdeformed band in which this bifurcation was observed. This first observation of {Delta}I=4 bifurcation in identical superdeformed bands provides a crucial test of recent models. {copyright} {ital 1997} {ital The American Physical Society}

  20. Strategic Thoughts on Economic Integration of Yangtze Delta

    Institute of Scientific and Technical Information of China (English)

    Xu Cong

    2008-01-01

    @@ Importance of integration to China's economy Shanghai,Jiangsu and Zhejiang,the three provinces and cities around Yangtze Delta area,are not only related in geography,but also enjoy similar type of culture and economy.With 2.2%of the national land area.10.4%of national population.the Yangtze Delta has created 22.1%of the national GDP,24.5%of the national fiscal revenues and 28.5%of the total imports and exports in the country.which has already made it become one of the most advanced areas in science,technology and culture in China.

  1. CMOS sigma-delta converters practical design guide

    CERN Document Server

    De la Rosa, Jose M

    2013-01-01

    A comprehensive overview of Sigma-Delta Analog-to-Digital Converters (ADCs) and a practical guide to their design in nano-scale CMOS for optimal performance. This book presents a systematic and comprehensive compilation of sigma-delta converter operating principles, the new advances in architectures and circuits, design methodologies and practical considerations - going from system-level specifications to silicon integration, packaging and measurements, with emphasis on nanometer CMOS implementation. The book emphasizes practical design issues - from high-level behavioural modelling i

  2. Feedback Linearization Controller Of The Delta WingRock Phenomena

    Directory of Open Access Journals (Sweden)

    Mohammed Alkandari

    2015-05-01

    Full Text Available This project deals with the control of the wing rock phenomena of a delta wing aircraft. a control schemeis proposed to stabilize the system. The controlleris a feedback linearization controller. It is shown that the proposed control scheme guarantee the asymptotic convergence to zero of all the states of the system. To illustrate the performance of the proposed controller, simulation results are presented and discussed. It is found that the proposed control scheme work well for the wing rock phenomena of a delta wing aircraft.

  3. Monte Carlo simulations of the stability of delta-Pu

    DEFF Research Database (Denmark)

    Landa, A.; Soderlind, P.; Ruban, Andrei

    2003-01-01

    The transition temperature (T-c) for delta-Pu has been calculated for the first time. A Monte Carlo method is employed for this purpose and the effective cluster interactions are obtained from first-principles calculations incorporated with the Connolly-Williams and generalized perturbation methods....... It is found that at T-c similar to 548 K, delta-Pu undergoes transformation from a disordered magnetic state to a structure with an anti ferromagnetic spin alignment that is mechanically unstable with respect to tetragonal distortion. The calculated transition temperature is in good agreement...

  4. Metabolite Signatures of Metabolic Risk Factors and their Longitudinal Changes

    NARCIS (Netherlands)

    Yin, X.; Subramanian, S.; Willinger, C.M.; Chen, G.; Juhasz, P.; Courchesne, P.; Chen, B.H.; Li, X.; Hwang, S.J.; Fox, C.S.; O'Donnell, C.J.; Muntendam, P.; Fuster, V.; Bobeldijk-Pastorova, I.; Sookoian, S.C.; Pirola, C.J.; Gordon, N.; Adourian, A.; Larson, M.G.; Levy, D.

    2016-01-01

    Context: Metabolic dysregulation underlies key metabolic risk factors—obesity, dyslipidemia, and dysglycemia. Objective: To uncover mechanistic links between metabolomic dysregulation and metabolic risk by testing metabolite associations with risk factors cross-sectionally and with risk factor

  5. β-Orcinol Metabolites from the Lichen Hypotrachyna revoluta

    Directory of Open Access Journals (Sweden)

    Panagiota Papadopoulou

    2007-05-01

    Full Text Available Four new β-orcinol metabolites, hypotrachynic acid (1, deoxystictic acid (2, cryptostictinolide (3 and 8 ́-methylconstictic acid (4 along with the metabolites 8 ́-methylstictic acid (5, 8 ́-methylmenegazziaic acid (6, stictic acid (7, 8 ́-ethylstictic acid (8 and atranorin (9, that have been previously described, were isolated for the first time from the tissue extracts of the lichen Hypotrachyna revoluta (Flörke Hale. The structures of the new metabolites were elucidated on the basis of extensive spectroscopic analyses. Radical scavenging activity (RSA of the metabolites isolated in adequate amounts, was evaluated using luminol chemiluminescence and comparison with Trolox®.

  6. Metabolite Signatures of Metabolic Risk Factors and their Longitudinal Changes

    NARCIS (Netherlands)

    Yin, X.; Subramanian, S.; Willinger, C.M.; Chen, G.; Juhasz, P.; Courchesne, P.; Chen, B.H.; Li, X.; Hwang, S.J.; Fox, C.S.; O'Donnell, C.J.; Muntendam, P.; Fuster, V.; Bobeldijk-Pastorova, I.; Sookoian, S.C.; Pirola, C.J.; Gordon, N.; Adourian, A.; Larson, M.G.; Levy, D.

    2016-01-01

    Context: Metabolic dysregulation underlies key metabolic risk factors—obesity, dyslipidemia, and dysglycemia. Objective: To uncover mechanistic links between metabolomic dysregulation and metabolic risk by testing metabolite associations with risk factors cross-sectionally and with risk factor chang

  7. Ruta graveolens Extracts and Metabolites against Spodoptera frugiperda.

    Science.gov (United States)

    Ayil-Gutiérrez, Benjamin A; Villegas-Mendoza, Jesús M; Santes-Hernndez, Zuridai; Paz-González, Alma D; Mireles-Martínez, Maribel; Rosas-García, Ninfa M; Rivera, Gildardo

    2015-11-01

    The biological activity of Ruta graveolens leaf tissue extracts obtained with different solvents (ethyl acetate, ethanol, and water) and metabolites (psoralen, 2- undecanone and rutin) against Spodoptera frugiperda was evaluated. Metabolites levels in extracts were quantified by HPLC and GC. Ethyl acetate and ethanol extracts showed 94% and 78% mortality, respectively. Additionally, psoralen metabolite showed a high mortality as cypermethrin. Metabolite quantification in extracts shows the presence of 2-undecanone (87.9 µmoles mg(-1) DW), psoralen (3.6 µmoles mg(-1) DW) and rutin (0.001 pmoles mg(-1) DW). We suggest that these concentrations of 2-undecanone and psoralen in R. graveolens leaf tissue extracts could be responsible for S. frugiperda mortality.

  8. Detection of mastitis pathogens by analysis of volatile bacterial metabolites

    NARCIS (Netherlands)

    Hettinga, K.A.; Valenberg, van H.J.F.; Lam, T.J.G.M.; Hooijdonk, van A.C.M.

    2008-01-01

    The ability to detect mastitis pathogens based on their volatile metabolites was studied. Milk samples from cows with clinical mastitis, caused by Staphylococcus aureus, coagulase-negative staphylococci, Streptococcus uberis, Streptococcus dysgalactiae, and Escherichia coli were collected. In

  9. Metabolite essentiality elucidates robustness of Escherichia coli metabolism

    CERN Document Server

    Kim, Pan-Jun; Kim, Tae Yong; Lee, Kwang Ho; Jeong, Hawoong; Lee, Sang Yup; Park, Sunwon

    2007-01-01

    Complex biological systems are very robust to genetic and environmental changes at all levels of organization. Many biological functions of Escherichia coli metabolism can be sustained against single-gene or even multiple-gene mutations by using redundant or alternative pathways. Thus, only a limited number of genes have been identified to be lethal to the cell. In this regard, the reaction-centric gene deletion study has a limitation in understanding the metabolic robustness. Here, we report the use of flux-sum, which is the summation of all incoming or outgoing fluxes around a particular metabolite under pseudo-steady state conditions, as a good conserved property for elucidating such robustness of E. coli from the metabolite point of view. The functional behavior, as well as the structural and evolutionary properties of metabolites essential to the cell survival, was investigated by means of a constraints-based flux analysis under perturbed conditions. The essential metabolites are capable of maintaining a...

  10. Comparison of the selected secondary metabolite content present in ...

    African Journals Online (AJOL)

    Comparison of the selected secondary metabolite content present in the ... and gravimetric methods, to the effect of quantitative comparison of their phenolic, ... The extracts were also qualitatively analyzed so as to evaluate the presence of ...

  11. Induced sclerotium formation exposes new bioactive metabolites from Aspergillus sclerotiicarbonarius.

    Science.gov (United States)

    Petersen, Lene M; Frisvad, Jens C; Knudsen, Peter B; Rohlfs, Marko; Gotfredsen, Charlotte H; Larsen, Thomas O

    2015-10-01

    Sclerotia are known to be fungal survival structures, and induction of sclerotia may prompt production of otherwise undiscovered metabolites. Aspergillus sclerotiicarbonarius (IBT 28362) was investigated under sclerotium producing conditions, which revealed a highly altered metabolic profile. Four new compounds were isolated from cultivation under sclerotium formation conditions and their structures elucidated using different analytical techniques (HRMS, UV, 1D and 2D NMR). This included sclerolizine, an alkylated and oxidized pyrrolizine, the new emindole analog emindole SC and two new carbonarins; carbonarins I and J. We have identified the three latter as true sclerotial metabolites. All metabolites were tested for antifungal and antiinsectan activity, and sclerolizine and carbonarin I displayed antifungal activity against Candida albicans, while all four showed antiinsectan activity. These results demonstrate induction of sclerotia as an alternative way of triggering otherwise silent biosynthetic pathways in filamentous fungi for the discovery of novel bioactive secondary metabolites.

  12. High Resolution Screening of biologically active compounds and metabolites

    NARCIS (Netherlands)

    Kool, J.

    2007-01-01

    High Resolution Screening of biologically active compounds and metabolites Jeroen Kool Biotransformation enzymes play a crucial role in the metabolism of both endogenous compounds and xenobiotics. Usually, the detoxication of these compounds by biotransformation enzymes results in harmless metab

  13. Fusarial toxins: secondary metabolites of Fusarium fungi.

    Science.gov (United States)

    Nesic, Ksenija; Ivanovic, Snezana; Nesic, Vladimir

    2014-01-01

    Exposure to mycotoxins occurs worldwide, even though there are geographic and climatic differences in the amounts produced and occurrence of these substances.Mycotoxins are secondary chemical metabolites of different fungi. They are natural contaminants of cereals, so their presence is often inevitable. Among many genera that produce mycotoxins, Fusarium fungi are the most widespread in cereal-growing areas of the planet. Fusarium fungi produce a diversity of mycotoxin types, whose distributions are also diverse. What is produced and where it is produced is influenced primarily by environmental conditions, and crop production and storage methods. The amount of toxin produced depends on physical (viz., moisture, relative humidity, temperature, and mechanical damage), chemical (viz., carbon dioxide,oxygen, composition of substrate, insecticides and fungicides), and biological factors (viz., plant variety, stress, insects, spore load, etc.). Moisture and temperature have a major influence on mold growth rate and mycotoxin production.Among the most toxic and prevalent fusaria) toxins are the following: zearalenone,fumonisins, moniliformin and trichothecenes (T-2/HT-2 toxin, deoxynivalenol,diacetoxyscirpenol, nivalenol). Zearalenone (ZEA; ZON, F-2 toxin) isaphy to estrogenic compound, primarily a field contaminant, which exhibits estrogenic activity and has been implicated in numerous mycotoxicoses of farm animals,especially pigs. Recently, evidence suggests that ZEA has potential to stimulate the growth of human breast cancer cells. Fumonisins are also cancer-promoting metabolites,of which Fumonisin 8 I (FBI) is the most important. Moniliformin (MON) isalso highly toxic to both animals and humans. Trichothecenes are classified as gastrointestinal toxins, dermatotoxins, immunotoxins, hematotoxins, and gene toxins.T-2 and HT-2 toxin, and diacetoxyscirpenol (DAS, anguidine) are the most toxic mycotoxins among the trichothecene group. Deoxynivalenol (DON, vomitoxin) and

  14. Acrolein metabolites, diabetes and insulin resistance.

    Science.gov (United States)

    Feroe, Aliya G; Attanasio, Roberta; Scinicariello, Franco

    2016-07-01

    Acrolein is a dietary and environmental pollutant that has been associated in vitro to dysregulate glucose transport. We investigated the association of urinary acrolein metabolites N-acetyl-S-(3-hydroxypropyl)-l-cysteine (3-HPMA) and N-acetyl-S-(carboxyethyl)-l-cysteine (CEMA) and their molar sum (∑acrolein) with diabetes using data from investigated 2027 adults who participated in the 2005-2006 National Health and Nutrition Examination Survey (NHANES). After excluding participants taking insulin or other diabetes medication we, further, investigated the association of the compounds with insulin resistance (n=850), as a categorical outcome expressed by the homeostatic model assessment (HOMA-IR>2.6). As secondary analyses, we investigated the association of the compounds with HOMA-IR, HOMA-β, fasting insulin and fasting plasma glucose. The analyses were performed using urinary creatinine as independent variable in the models, and, as sensitivity analyses, the compounds were used as creatinine corrected variables. Diabetes as well as insulin resistance (defined as HOMA-IR>2.6) were positively associated with the 3-HPMA, CEMA and ∑Acrolein with evidence of a dose-response relationship (pCEMA compared to the lowest quartile were significantly associated with higher HOMA-IR, HOMA-β and fasting insulin with a dose-response relationship. The highest 3rd quartile of 3-HPMA and ∑Acrolein were positively and significantly associated with HOMA-IR, HOMA-β and fasting insulin. These results suggest a need of further studies to fully understand the implications of acrolein with type 2 diabetes and insulin.

  15. Metabolic Enzymes of Cocaine Metabolite Benzoylecgonine.

    Science.gov (United States)

    Chen, Xiabin; Zheng, Xirong; Zhan, Max; Zhou, Ziyuan; Zhan, Chang-Guo; Zheng, Fang

    2016-08-19

    Cocaine is one of the most addictive drugs without a U.S. Food and Drug Administration (FDA)-approved medication. Enzyme therapy using an efficient cocaine-metabolizing enzyme is recognized as the most promising approach to cocaine overdose treatment. The actual enzyme, known as RBP-8000, under current clinical development for cocaine overdose treatment is our previously designed T172R/G173Q mutant of bacterial cocaine esterase (CocE). The T172R/G173Q mutant is effective in hydrolyzing cocaine but inactive against benzoylecgonine (a major, biologically active metabolite of cocaine). Unlike cocaine itself, benzoylecgonine has an unusually stable zwitterion structure resistant to further hydrolysis in the body and environment. In fact, benzoylecgonine can last in the body for a very long time (a few days) and, thus, is responsible for the long-term toxicity of cocaine and a commonly used marker for drug addiction diagnosis in pre-employment drug tests. Because CocE and its mutants are all active against cocaine and inactive against benzoylecgonine, one might simply assume that other enzymes that are active against cocaine are also inactive against benzoylecgonine. Here, through combined computational modeling and experimental studies, we demonstrate for the first time that human butyrylcholinesterase (BChE) is actually active against benzoylecgonine, and that a rationally designed BChE mutant can not only more efficiently accelerate cocaine hydrolysis but also significantly hydrolyze benzoylecgonine in vitro and in vivo. This sets the stage for advanced studies to design more efficient mutant enzymes valuable for the development of an ideal cocaine overdose enzyme therapy and for benzoylecgonine detoxification in the environment.

  16. Choline metabolites: gene by diet interactions.

    Science.gov (United States)

    Smallwood, Tangi; Allayee, Hooman; Bennett, Brian J

    2016-02-01

    The review highlights recent advances in our understanding of the interactions between genetic polymorphisms in genes that metabolize choline and the dietary requirements of choline and how these interactions relate to human health and disease. The importance of choline as an essential nutrient has been well established, but our appreciation of the interaction between our underlying genetic architecture and dietary choline requirements is only beginning. It has been shown in both human and animal studies that choline deficiencies contribute to diseases such as nonalcoholic fatty liver disease and various neurodegenerative diseases. An adequate supply of dietary choline is important for optimum development, highlighted by the increased maternal requirements during fetal development and in breast-fed infants. We discuss recent studies investigating variants in PEMT and MTHFR1 that are associated with a variety of birth defects. In addition to genetic interactions, we discuss several recent studies that uncover changes in fetal global methylation patterns in response to maternal dietary choline intake that result in changes in gene expression in the offspring. In contrast to the developmental role of adequate choline, there is now an appreciation of the role choline has in cardiovascular disease through the gut microbiota-mediated metabolite trimethylamine N-oxide. This pathway highlights some of our understanding of how the microbiome affects nutrient processing and bioavailability. Finally, to better characterize the genetic architecture regulating choline requirements, we discuss recent results focused on identifying polymorphisms that regulate choline and its derivative products. Here we discuss recent studies that have advanced our understanding of how specific alleles in key choline metabolism genes are related to dietary choline requirements and human disease.

  17. Bioactive Metabolites from Spilanthes acmella Murr.

    Directory of Open Access Journals (Sweden)

    Virapong Prachayasittikul

    2009-02-01

    Full Text Available Spilanthes acmella Murr. (Compositae has been used as a traditional medicine for toothache, rheumatism and fever. Its extracts had been shown to exhibit vasorelaxant and antioxidant activities. Herein, its antimicrobial, antioxidant and cytotoxic activities were evaluated. Agar dilution method assays against 27 strains of microorganisms were performed. Results showed that fractions from the chloroform and methanol extracts inhibited the growth of many tested organisms, e.g. Corynebacterium diphtheriae NCTC 10356 with minimum inhibitory concentration (MIC of 64-256 mg/mL and Bacillus subtilis ATCC 6633 with MIC of 128-256 mg/mL. The tested fractions all exhibited antioxidant properties in both DPPH and SOD assays. Potent radical scavenging activity was observed in the DPPH assay. No cytotoxic effects of the extracts against KB and HuCCA-1 cell lines were evident. Bioassay-guided isolation resulted in a diverse group of bioactive compounds such as phenolics [vanillic acid (2, trans-ferulic acid (5 and trans-isoferulic acid (6], coumarin (scopoletin, 4 and triterpenoids like 3-acetylaleuritolic acid (1, b-sitostenone (3, stigmasterol and stigmasteryl-3-O-b-D-glucopyranosides, in addition to a mixture of stigmasteryl-and b-sitosteryl-3-O-b-D-glucopyranosides. The compounds 1–6 represent bioactive metabolites of S. acmella Murr. that were never previously reported. Our findings demonstrate for the first time the potential benefits of this medicinal plant as a rich source of high therapeutic value compounds for medicines, cosmetics, supplements and as a health food.

  18. Biologically active secondary metabolites from Asphodelus microcarpus.

    Science.gov (United States)

    Ghoneim, Mohammed M; Ma, Guoyi; El-Hela, Atef A; Mohammad, Abd-Elsalam I; Kottob, Saeid; El-Ghaly, Sayed; Cutler, Stephen J; Ross, Samir A

    2013-08-01

    Bioassay guided fractionation of the ethanolic extract of Asphodelus microcarpus Salzm.et Vivi (Asphodelaceae) resulted in the isolation of one new metabolite, 1,6-dimethoxy-3-methyl-2-naphthoic acid (1) as well as nine known compounds: asphodelin (2), chrysophanol (3), 8-methoxychrysophanol (4), emodin (5), 2-acetyl-1,8-dimethoxy-3-methylnaphthalene (6), 10-(chrysophanol-7'-yl)-10-hydroxychrysophanol-9-anthrone (7), aloesaponol-III-8-methyl ether (8), ramosin (9) and aestivin (10). The compounds were identified by 1D and 2D NMR and HRESIMS. Compounds 3, 6 and 10 were isolated for the first time from this species. Compounds 3 and 4 showed moderate to weak antileishmanial activity with IC50 values of 14.3 and 35.1 microg/mL, respectively. Compound 4 exhibited moderate antifungal activity against Cryptococcus neoformans with an IC50 value of 15.0 microg/mL, while compounds 5, 7 and 10 showed good to potent activity against methicillin resistant Staphylococcus aureus (MRSA) with IC50 values of 6.6, 9.4 microg/mL and 1.4 microg/mL respectively. Compounds 5, 8 and 9 displayed good activity against S. aureus with IC50 values of 3.2, 7.3 and 8.5 microg/mL, respectively. Compounds 7 and 9 exhibited a potent cytotoxic activity against leukemia LH60 and K562 cell lines. Compound 10 showed potent antimalarial activities against both chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum with IC50 values in the range of 0.8-0.7 microg/mL without showing any cytotoxicity to mammalian cells.

  19. Metabolites of Hypoxic Cardiomyocytes Induce the Migration of Cardiac Fibroblasts.

    Science.gov (United States)

    Shi, Huairui; Zhang, Xuehong; He, Zekun; Wu, Zhiyong; Rao, Liya; Li, Yushu

    2017-01-01

    The migration of cardiac fibroblasts to the infarct region plays a major role in the repair process after myocardial necrosis or damage. However, few studies investigated whether early hypoxia in cardiomyocytes induces the migration of cardiac fibroblasts. The purpose of this study was to assess the role of metabolites of early hypoxic cardiomyocytes in the induction of cardiac fibroblast migration. Neonatal rat heart tissue was digested with a mixture of trypsin and collagenase at an appropriate ratio. Cardiomyocytes and cardiac fibroblasts were cultured via differential adhesion. The cardiomyocyte cultures were subjected to hypoxia for 2, 4, 6, 8, 10, and 12 h. The supernatants of the cardiomyocyte cultures were collected to determine the differences in cardiac fibroblast migration induced by hypoxic cardiomyocyte metabolites at various time points using a Transwell apparatus. Meanwhile, ELISA was performed to measure TNF-α, IL-1β and TGF-β expression levels in the cardiomyocyte metabolites at various time points. The metabolites of hypoxic cardiomyocytes significantly induced the migration of cardiac fibroblasts. The induction of cardiac fibroblast migration was significantly enhanced by cardiomyocyte metabolites in comparison to the control after 2, 4, and 6 h of hypoxia, and the effect was most significant after 2 h. The expression levels of TNF-α, IL-1β, IL-6, and TGF-β were substantially increased in the metabolites of cardiomyocytes, and neutralization with anti-TNF-α and anti-IL-1β antibodies markedly reduced the induction of cardiac fibroblast migration by the metabolites of hypoxic cardiomyocytes. The metabolites of early hypoxic cardiomyocytes can induce the migration of cardiac fibroblasts, and TNF-α and IL-1β may act as the initial chemotactic inducers. © 2017 The Author(s) Published by S. Karger AG, Basel.

  20. Phytotoxic metabolites produced by Botryosphaeriaceae involved in grapevine trunk diseases

    OpenAIRE

    Basso, Sara; Andolfi, Anna; Maddau, Lucia; Linaldeddu, Benedetto Teodoro; Deidda, Antonio; Serra, Salvatorica; Cimmino, Alessio; Evidente, Antonio

    2013-01-01

    Fungi belonging to the Botryosphaeriaceae family are well known as cosmopolitan pathogens, saprophytes and endophytes and occur on a wide range of hosts including grapevine. More recently, a new species of Lasiodiplodia was isolated from declining grapevines in Sardinia (Italy). This still undescribed species showed to produce in liquid culture several phytotoxic secondary metabolites. In this communication the chemical and biological characterization of these bioactive secondary metabolit...