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Sample records for delft leiden bsdl

  1. Milieupagina Delft is Europroof

    NARCIS (Netherlands)

    Borst, H.C.

    2006-01-01

    TNO en de gemeente Delft hebben een website ontwikkeld om lokale milieu-informatie toegankelijk te maken voor een breed publiek. Op deze site staan interactieve miliekaarten van geluid en luchtverontreiniging door wegverkeer. Met dit initiatief voldoet de gemeente Delft in één klap voor een

  2. Leerstoel Installaties TU Delft

    NARCIS (Netherlands)

    Luscuere, P.G.; Zeiler, W.; Cauberg, J.J.M.; van der Linden, A.C.; Dobbelsteen, A.A.J.F.

    2007-01-01

    De leerstoel Installaties aan de TU Delft heeft een lange geschiedenis. De laatste decennia heeft Peter Luscuere de leerstoel in deeltijd bezet en zo een belangrijke bijdrage geleverd aan de koppeling van Onderzoek, Onderwijs en Ondernemen. Het artikel start met een korte beschrijving van de huidige

  3. Standhouden in Delft

    NARCIS (Netherlands)

    De Jong, F.

    1997-01-01

    Technology is still masculine, and so is the Technical University at Delft. Frequently the question is asked: who were the first woman teacher and woman student? More interesting, however, is the question how women participated in this domain throughout history and how they managed to survive. This

  4. The Delft-Java Engine

    NARCIS (Netherlands)

    Glossner III, C.J.

    2001-01-01

    In this dissertation, we describe the DELFT-JAVA engine - a 32-bit RISC-based architecture that provides high performance JAVA program execution. More specifically we describe a microarchitecture that accelerates JAVA execution and provide details of the DELFT-JAVA architecture for executing JAVA

  5. Study of Delft aerospace alumni

    NARCIS (Netherlands)

    Smits, G.N.

    2008-01-01

    This thesis reports on an alumni study of the Faculty Aerospace Engineering at Delft University of Technology to discover what the impact is of the degree in aerospace engineering on an alumnus' professional success and comment on what are important qualities for aerospace engineers to have in order

  6. Teaching urbanism : the Delft approach

    NARCIS (Netherlands)

    Nijhuis, S.; Stolk, E.H.; Hoekstra, M.J.

    2016-01-01

    The Department of Urbanism at the Faculty of Architecture and Built Environment at the Delft University of Technology has a long tradition in educating generations of internationally oriented designers, planners and researchers in urbanism. Here the domain of urbanism is defined as an

  7. Psychology students from Leiden University

    DEFF Research Database (Denmark)

    Singla, Rashmi

    2017-01-01

    We are glad to share with our department that a group of 41 Psychology students from Leiden university, Holland were on a three hours visit to RUC Psychology department on Friday , 10.3.2017. The department is a valuable partner for students’ exchange , almost every semester there are RUC students...... travelling to Leiden. The trip was planned by Study Association Labyrint Leiden, and consisted of students at all levels from the bachelor as well as masters programs. A group of RUC psychology students Wiebke Sandermann; Emma Stinne Engstrøm; Mikkel Brilner Lund were in the organising group along...... with the study director Hans Sønderstrup Hansen and Rashmi Singla. It was an enriching experience for the RUC organizing group. International coordinator for Psychology Dieuwerke de Groot in Leiden reciprocated by writing: “A very enthusiastic mail from our students telling me they had such a wonderful time...

  8. The Delft-FEWS flow forecasting system

    NARCIS (Netherlands)

    Werner, M.; Schellekens, J.; Gijsbers, P.; van Dijk, M.; van den Akker, O.; Heynert, K.

    2013-01-01

    Since its introduction in 2002/2003, the current generation of the Delft-FEWS operational forecasting platform has found application in over forty operational centres. In these it is used to link data and models in real time, producing forecasts on a daily basis. In some cases it forms a building

  9. Options for the Delft advanced neutron source

    International Nuclear Information System (INIS)

    Gibcus, H.P.M.; Leege, P.F.A. de; Labohm, F.; Vries, J.W. de; Verkooijen, A.H.M.; Valko, J.; Feltes, W.; Heinecke, J.

    2003-01-01

    Results of feasibility studies are presented for options for an advanced neutron source for the Delft reactor including upgrading the HOR, a 2 MW pool-type research reactor at the Delft University of Technology. The primary utilisation of the HOR focuses on beam research applications with neutrons and positrons. The aim of being scientifically competitive in that research area requires a thermal neutron flux level of at least 1x10 14 n/cm 2 /s. The feasibility of an accelerator driven neutron source and upgrading the present core to a super compact core for reaching this goal has been investigated at large from a safety and operational point of view. For the upgraded core, a 3x3 fuel assembly arrangement and beryllium reflected at all sides was chosen. Figures on the system performance, including the merits of a cold neutron source application feeding the neutron guide system, are presented. (author)

  10. Factor V Leiden mutation in pregnancy.

    Science.gov (United States)

    Cohen, Susan Murphy

    2004-01-01

    Normal maternal adaptation to pregnancy significantly increases the risk for thrombus formation. Inherited thrombophilias further increase risk for deep venous thrombosis and adverse outcome in pregnancy. Factor V Leiden mutation is the most common inherited thrombophilia, occurring in approximately 5% of the White and 1% of the Black populations. Nurses should be knowledgeable about screening for and diagnosis of factor V Leiden mutation, risk reduction counseling, recommended care of the affected patient, and implications of anticoagulant therapy during the perinatal period.

  11. TU Delft expert judgment data base

    International Nuclear Information System (INIS)

    Cooke, Roger M.; Goossens, Louis L.H.J.

    2008-01-01

    We review the applications of structured expert judgment uncertainty quantification using the 'classical model' developed at the Delft University of Technology over the last 17 years [Cooke RM. Experts in uncertainty. Oxford: Oxford University Press; 1991; Expert judgment study on atmospheric dispersion and deposition. Report Faculty of Technical Mathematics and Informatics No.01-81, Delft University of Technology; 1991]. These involve 45 expert panels, performed under contract with problem owners who reviewed and approved the results. With a few exceptions, all these applications involved the use of seed variables; that is, variables from the experts' area of expertise for which the true values are available post hoc. Seed variables are used to (1) measure expert performance, (2) enable performance-based weighted combination of experts' distributions, and (3) evaluate and hopefully validate the resulting combination or 'decision maker'. This article reviews the classical model for structured expert judgment and the performance measures, reviews applications, comparing performance-based decision makers with 'equal weight' decision makers, and collects some lessons learned

  12. Cryogenic rocket engine development at Delft aerospace rocket engineering

    NARCIS (Netherlands)

    Wink, J; Hermsen, R.; Huijsman, R; Akkermans, C.; Denies, L.; Barreiro, F.; Schutte, A.; Cervone, A.; Zandbergen, B.T.C.

    2016-01-01

    This paper describes the current developments regarding cryogenic rocket engine technology at Delft Aerospace Rocket Engineering (DARE). DARE is a student society based at Delft University of Technology with the goal of being the first student group in the world to launch a rocket into space. After

  13. Parking Spoorzone Delft : Addressing expected parking challenges 2015-2017

    NARCIS (Netherlands)

    Piccot, C.; Groenendijk, L.; Rot, M.; Van der Meijs, P.; Rakers, T.; Negenborn, R.R.; Annema, J.A.; Pel, A.; Vleugel, J.

    2014-01-01

    This project is carried out on request of the BVOW, the interest group of the neighbourhoods Olofsbuurt and Westerkwartier in Delft, in order to propose solutions for the parking issue of Spoorzone Delft expected between 2015 and 2017. They are worried that parking disturbances will emerge in their

  14. Defining a Pedagogical Model: The TU Delft Online Learning Experience

    NARCIS (Netherlands)

    Ribeiro Jorge, N.; Dopper, S.M.; van Valkenburg, W.F.

    2015-01-01

    In early 2014, the Delft University of Technology (TU Delft) started an innovation program with the aim to respond even more effectively to recent developments in open and online education. Drawing on the fields of Distance Education research and the university’s vision of the “engineer of the

  15. Het oude en nieuwe gasthuis te Delft, (1252-1795)

    NARCIS (Netherlands)

    Oosterbaan, Dinant Petrus

    1954-01-01

    Il est fait mention pour la première fois de l'Ancien et du Nouvel Hopital de Delft (Oude en Nieuwe Gasthuis) dans une bulle du Pape Innocent IV, datée du 11 Octobre 1252. On cite également cette institution dans un récit de voyage de ce temps, publié dans la Description de la Ville de Delft par

  16. Integrated Biogeomorphological Modeling Using Delft3D

    Science.gov (United States)

    Ye, Q.; Jagers, B.

    2011-12-01

    The skill of numerical morphological models has improved significantly from the early 2D uniform, total load sediment models (with steady state or infrequent wave updates) to recent 3D hydrodynamic models with multiple suspended and bed load sediment fractions and bed stratigraphy (online coupled with waves). Although there remain many open questions within this combined field of hydro- and morphodynamics, we observe an increasing need to include biological processes in the overall dynamics. In riverine and inter-tidal environments, there is often an important influence by riparian vegetation and macrobenthos. Over the past decade more and more researchers have started to extend the simulation environment with wrapper scripts and other quick code hacks to estimate their influence on morphological development in coastal, estuarine and riverine environments. Although one can in this way quickly analyze different approaches, these research tools have generally not been designed with reuse, performance and portability in mind. We have now implemented a reusable, flexible, and efficient two-way link between the Delft3D open source framework for hydrodynamics, waves and morphology, and the water quality and ecology modules. The same link will be used for 1D, 2D and 3D modeling on networks and both structured and unstructured grids. We will describe the concepts of the overall system, and illustrate it with some first results.

  17. Mechanisms of the factor V Leiden paradox

    NARCIS (Netherlands)

    van Stralen, K. J.; Doggen, C. J. M.; Bezemer, I. D.; Pomp, E. R.; Lisman, T.; Rosendaal, F. R.

    2008-01-01

    Objective-Carriers of the factor V Leiden mutation (FVL-carriers) have a substantially increased risk of deep venous thrombosis (DVT), whereas the risk of pulmonary embolism (PE) is only mildly increased compared with noncarriers. So far few studies have investigated possible mechanisms for this

  18. Frequency of factor V Leiden mutation

    International Nuclear Information System (INIS)

    Nasiruddin; Ali, W.; Rehman, Z.; Anwar, M.; Ayyub, M.; Ali, W.; Ahmed, S.

    2005-01-01

    Objective: To determine the frequency of factor V Leiden mutation. Design: Observational study. Patients and Methods: Two hundred subjects each of apparently healthy and unrelated Punjabi and Pathan origins were included in the study. Peripheral blood samples were collected in EDTA and DNA extracted by phenol- chloroform extraction method. DNA analysis was done by PCR for restriction fragment length polymorphism. The product was digested overnight with Mn/1 and electrophoresed on acrylamide gel to detect 67 and 153 base pair fragments of factor V Leiden against 37, 67 and 116 base pair fragments of normal factor V. Results: In the 400 subjects studied, only 5 cases of heterozygotes for factor V Leiden were detected. The overall carrier rate was 1.3% (95% CI 0.2-2.2%). The carrier rate in Punjabis and Pathans was 1 % and 1.5% respectively. Conclusion: This study confirms that the prevalence of factor V Leiden is low in Asians and Africans as compared to the European population. (author)

  19. Polychaeten aus den Zoologischen Museen von Leiden und Amsterdam I

    NARCIS (Netherlands)

    Augener, H.

    1933-01-01

    In der vorliegenden Arbeit ist die Untersuchung eines sehr umfangreichen Polychaeten-Materials niedergelegt, das mir von Herrn Prof. Dr. E. D. van Oort in Leiden und Herrn Prof. Dr. L. F. de Beaufort in Amsterdam zur Bearbeitung übergeben wurde. Von diesem Material ist der dem Museum in Leiden

  20. 3E. Climate policy plan Delft, Netherlands, 2003-2012. Effectiveness, Efficiency, Energy Consumption

    International Nuclear Information System (INIS)

    2003-09-01

    The 3E: Klimaatplan Delft; (Delft Climate Plan)' is the Delft interpretation of the Kyoto Convention, and is furthermore in line with the objectives of '3D: Duurzaamheidsplan Delft 2000-2003; (2002-2003 Delft Sustainability Plan)'. 3E stands for: effective, efficient energy consumption. The principal objective is an annual reduction of 33,500 tons of CO2 emissions, compared to 1999. This level of reduction should be realised not later than by 2012 (the final year of the plan period). On the basis of the Climate Scan performed by Novem, the largest environmental gain appears to come from (re-)construction processes and the use of sustainable energy [nl

  1. Comparison. US P-61 and Delft sediment samplers

    Science.gov (United States)

    Beverage, Joseph P.; Williams, David T.

    1990-01-01

    The Delft Bottle (DB) is a flow-through device designed by the Delft Hydraulic Laboratory (DHL), The Netherlands, to sample sand-sized sediment suspended in streams. The US P-61 sampler was designed by the Federal Interagency Sedimentation Project (FISP) at the St. Anthony Falls Hydraulic Laboratory, Minneapolis, Minnesota, to collect suspended sediment from deep, swift rivers. The results of two point-sampling tests in the United States, the Mississippi River near Vicksburg, Mississippi, in 1983 and the Colorado River near Blythe, California, in 1984, are provided in this report. These studies compare sand-transport rates, rather than total sediment-transport rates, because fine material washes through the DB sampler. In the United States, the commonly used limits for sand-sized material are 0.062 mm to 2.00 mm (Vanoni 1975).

  2. Leiden Mutation and the Course of Severe Acute Pancreatitis

    Directory of Open Access Journals (Sweden)

    A. V. Ershov

    2013-01-01

    Full Text Available Objective: to evaluate the impact of Leiden mutation on the course of severe acute pancreatitis. Subjects and methods. One hundred and twelve people were examined. Group 1 comprised 50 patients diagnosed with severe acute pancreatitis without coagulation factor V (Leiden mutation. Group 2 included 42 patients with severe acute pancreatitis who were found to have Leiden mutation. Acute pancreatitis was first diagnosed in both groups. Group 3 consisted of 20 apparently healthy individuals (a control group. The severity of the underlying disease was determined in accordance with the clinical and laboratory parameters recommended by the I. I. Dzhanelidze Saint Petersburg Research Institute of Emergence Care. Results. This investigation revealed an association of Leiden mutation with trends in the development of acute pancreatitis. Group 2 exhibited a more severe disease: large focal pancreatic necrosis was twice more common and infectious complications developed more frequently; more aggressive and radical treatments were more often used. The patients with Leiden mutation had higher mortality rates (33% in the Leiden mutation group and 24% in the non-mutation group. Conclusion. The findings should be kept in mind in elaborating new diagnostic methods and principles in the treatment of the underlying disease and in the prevention of its complications in patients with severe acute pancreatitis. Key words: acute pancreatitis, Leiden mutation.

  3. Fuel shuffling optimization for the Delft research reactor

    Energy Technology Data Exchange (ETDEWEB)

    Geemert, R. van; Hoogenboom, J.E.; Gibcus, H.P.M. [Delft Univ. of Technology, Interfaculty Reactor Inst., Delft (Netherlands); Quist, A.J. [Delft Univ., Fac. of Applied Mathematics and Informatics, Delft (Netherlands)

    1997-07-01

    A fuel shuffling optimization procedure is proposed for the Hoger Onderwijs Reactor (HOR) in Delft, the Netherlands, a 2 MWth swimming-pool type research reactor. In order to cope with the fluctuatory behaviour of objective functions in loading pattern optimization, the proposed cyclic permutation optimization procedure features a gradual transition from global to local search behaviour via the introduction of stochastic tests for the number of fuel assemblies involved in a cyclic permutation. The possible objectives and the safety and operation constraints, as well as the optimization procedure, are discussed, followed by some optimization results for the HOR. (author) 5 figs., 4 refs.

  4. Fuel shuffling optimization for the Delft research reactor

    International Nuclear Information System (INIS)

    Geemert, R. van; Hoogenboom, J.E.; Gibcus, H.P.M.; Quist, A.J.

    1997-01-01

    A fuel shuffling optimization procedure is proposed for the Hoger Onderwijs Reactor (HOR) in Delft, the Netherlands, a 2 MWth swimming-pool type research reactor. In order to cope with the fluctuatory behaviour of objective functions in loading pattern optimization, the proposed cyclic permutation optimization procedure features a gradual transition from global to local search behaviour via the introduction of stochastic tests for the number of fuel assemblies involved in a cyclic permutation. The possible objectives and the safety and operation constraints, as well as the optimization procedure, are discussed, followed by some optimization results for the HOR. (author)

  5. Fuel shuffling optimization for the Delft research reactor

    Energy Technology Data Exchange (ETDEWEB)

    Geemert, R. van; Hoogenboom, J.E.; Gibcus, H.P.M. [Delft Univ. of Technology, Interfaculty Reactor Inst., Delft (Netherlands); Quist, A.J. [Delft Univ., Fac. of Applied Mathematics and Informatics, Delft (Netherlands)

    1997-07-01

    A fuel shuffling optimization procedure is proposed for the Hoger Onderwijs Reactor (HOR) in Delft, the Netherlands, a 2 MWth swimming-pool type research reactor. In order to cope with the fluctuatory behaviour of objective functions in loading pattern optimization, the proposed cyclic permutation optimization procedure features a gradual transition from global to local search behaviour via the introduction of stochastic tests for the number of fuel assemblies involved in a cyclic permutation. The possible objectives and the safety and operation constraints, as well as the optimization procedure, are discussed, followed by some optimization results for the HOR. (author)

  6. Survey of HTR related research at IRI, Delft, Netherlands

    Energy Technology Data Exchange (ETDEWEB)

    Hoogenboom, J.E.; Wallerbos, E.J.M.; Van der Hagen, T.H.J.J.; Van Dam, H. [Interfaculty Reactor Institute IRI, Delft University of Technology, Delft (Netherlands); Tuerkcan, E. [ECN Nuclear Research, Petten (Netherlands)

    1998-09-01

    High temperature helium-cooled reactors have a large potential for inherent safety. Therefore, several projects on HTR research are being carried out or were carried out at the Interfaculty Reactor Institute (IRI) of the Delft University of Technology in Delft, Netherlands. As part of a larger research programme measurements of core reactivity, reactivity worth of safety rods and of small samples being oscillated in the reactor core were carried out at the PROTEUS facility of the Paul Scherrer Institute at Villigen, Switzerland. Together with other partners in the Netherlands a small inherently safe co-generation plant with a pebble-bed HTR core was designed and analysed. It was verified that such a reactor can operate continuously for 10 years by adding continuously fuel pebbles until the maximum available core height is reached. As a new, innovative, inherently safe reactor type the design of a fluidized-bed reactor with coated fuel particles on a helium gas stream is discussed and results are shown for the analysis of inherent criticality safety under varying coolant flow rates. IRI is also taking part in the new IAEA Co-ordinated Research Programme, which involves participation in the start-up experiments of the Japanese HTTR and carrying out calculations for the core physics benchmark test. 11 refs.

  7. Fire and collapse, Faculty of Architecture building, Delft University of Technology: Data collection and preliminary analyses

    NARCIS (Netherlands)

    Meacham, B.; Park, H.; Engelhardt, M.; Kirk, A.; Kodur, V.; Straalen, IJ.J.; Maljaars, J.; Weeren, K. van; Feijter, R. de; Both, K.

    2010-01-01

    On the morning of May 13, 2008, a fire that started in a coffee vending machine on the 6th floor of the 13-story Faculty of Architecture Building at the Delft University of Technology (TUD), Delft, the Netherlands, quickly developed into an extreme loading event. Although all building occupants

  8. CWI and TU Delft at TREC 2013: Contextual Suggestion, Federated Web Search, KBA, and Web Tracks

    NARCIS (Netherlands)

    A. Bellogín Kouki (Alejandro); G.G. Gebremeskel (Gebre); J. He (Jiyin); J.J.P. Lin (Jimmy); A. Said (Alan); T. Samar (Thaer); A.P. de Vries (Arjen); J.B.P. Vuurens (Jeroen)

    2014-01-01

    htmlabstractThis paper provides an overview of the work done at the Centrum Wiskunde & Informatica (CWI) and Delft University of Technology (TU Delft) for different tracks of TREC 2013. We participated in the Contextual Suggestion Track, the Federated Web Search Track, the Knowledge Base

  9. 'Most Rare Workmen': Optical Practitioners in Early Seventeenth-Century Delft

    NARCIS (Netherlands)

    Zuidervaart, Huib J.; Rijks, Marlise

    2015-01-01

    A special interest in optics among various seventeenth-century painters living in the Dutch city of Delft has intrigued historians, including art historians, for a long time. Equally, the impressive career of the Delft microscopist Antoni van Leeuwenhoek has been studied by many historians of

  10. Influence of the factor V Leiden mutation on infectious disease susceptibility and outcome

    DEFF Research Database (Denmark)

    Benfield, Thomas L; Dahl, Mortens; Nordestgaard, Borge G

    2005-01-01

    The effect of the coagulation factor V Leiden mutation on infectious disease susceptibility and outcome is controversial.......The effect of the coagulation factor V Leiden mutation on infectious disease susceptibility and outcome is controversial....

  11. Multi-beam neutron guide system at IRI, Delft

    Energy Technology Data Exchange (ETDEWEB)

    Well, A.A. van; Gibcus, H.P.M.; Gommers, R.M.; Haan, V.O. de; Labohm, F.; Verkooijen, A.H.M. [Technische Univ. Delft (Netherlands). Interfacultair Reactor Inst.; Schebetov, A.; Pusenkov, V. [St. Petersburg Inst. of Nuclear Physics, Gatchina (Russian Federation)

    2001-07-01

    One of the main facilities of the Interfaculty Reactor Institute (IRI) at the Delft University of Technology is the swimming-pool type research reactor HOR. In 1963 it was critical for the first time. The power raised from 100 kW in 1963 to 500 kW in 1965. In 1968, forced cooling was introduced. From that time on, the reactor is operated at 2 MW, 5 days per week. The reactor comprises a variety of irradiation facilities, used among others for radioisotope production and neutron activation analysis. It is equipped with six horizontal radial beam tubes, originally used for neutron-scattering experiments. Throughout the years, the research activities have grown steadily, both in the development of new techniques and in applying these techniques in new research areas. (orig.)

  12. 21 CFR 864.7280 - Factor V Leiden DNA mutation detection systems.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Factor V Leiden DNA mutation detection systems....7280 Factor V Leiden DNA mutation detection systems. (a) Identification. Factor V Leiden deoxyribonucleic acid (DNA) mutation detection systems are devices that consist of different reagents and...

  13. Factor V Leiden is associated with increased sperm count

    NARCIS (Netherlands)

    van Mens, T. E.; Joensen, U. N.; Bochdanovits, Z.; Takizawa, A.; Peter, J.; Jørgensen, N.; Szecsi, P. B.; Meijers, J. C. M.; Weiler, H.; Rajpert-de Meyts, E.; Repping, S.; Middeldorp, S.

    2017-01-01

    STUDY QUESTION: Is the thrombophilia mutation factor V Leiden (FVL) associated with an increased total sperm count? SUMMARY ANSWER: Carriers of FVL have a higher total sperm count than non-FVL-carriers, which could not be explained by genetic linkage or by observations in a FVL-mouse model. WHAT IS

  14. Apolipoprotein E*3-Leiden transgenic mice mode for hypolipidaemic drugs

    NARCIS (Netherlands)

    Vlijmen, B.J.M. van; Pearce, N.J.; Bergö, M.; Staels, B.; Yates, J.W.; Gribble, A.D.; Bond, B.C.; Hofker, M.H.; Havekes, L.M.; Groot, P.H.E.

    1998-01-01

    Apolipoprotein (APO) E*3-Leiden mice with impaired chylomicron and VLDL (very low density lipoprotein) remnant metabolism display hyperlipidaemia and atherosclerosis. In the present study, these mice were used for testing the hypolipidaemic effect of two marketed agents, lovastatin (CAS 75330-75-5)

  15. Note sur les Buprestides du Museum de Leiden

    NARCIS (Netherlands)

    Thery, A.

    1935-01-01

    M. le Dr. H. C. Blöte, entomologiste du Rijksmuseum van Natuurlijke Historie à Leiden (Hollande) m'a confié l'étude de matériaux indéterminés appartenant aux collections de cet établissement, parmi ceux-ci j'ai trouvé quelques espèces nouvelles dont je donne ci-dessous la description. Les types de

  16. Die Leiden des jungen Werthers: Den unge Werthers lidelser

    OpenAIRE

    Wibe, Henriette Nøddebo; Mathiassen, Jonas Bundgaard; Villadsen, Line Møgelvang; Aeppli, Jon Marius Brogaard; Hvidtfeldt, Sidi Sami Idrissi; Jakobsen, Mathias Simonsen

    2013-01-01

    This project investigate the philosophical influence of Jean-Jaques Rousseau’s Discours sur I’origine et les fondemens de I’inégalité parmi les hommes on Johann Wolfgang von Goethe’s Die Leiden des jungen Werthers. The concepts of the natural and conscious man that are set forth in the second Discours are compared to Werthers dualistic selfhood and the influence this has on the understanding of the narrative of Werther. Furthermore the project assesses the extent to which the revised 1787 ver...

  17. Delft-FEWS:A Decision Making Platform to Intergrate Data, Model, Algorithm for Large-Scale River Basin Water Management

    Science.gov (United States)

    Yang, T.; Welles, E.

    2017-12-01

    In this paper, we introduce a flood forecasting and decision making platform, named Delft-FEWS, which has been developed over years at the Delft Hydraulics and now at Deltares. The philosophy of Delft-FEWS is to provide water managers and operators with an open shell tool, which allows the integratation of a variety of hydrological, hydraulics, river routing, and reservoir models with hydrometerological forecasts data. Delft-FEWS serves as an powerful tool for both basin-scale and national-scale water resources management. The essential novelty of Delft-FEWS is to change the flood forecasting and water resources management from a single model or agency centric paradigm to a intergrated framework, in which different model, data, algorithm and stakeholders are strongly linked together. The paper will start with the challenges in water resources managment, and the concept and philosophy of Delft-FEWS. Then, the details of data handling and linkages of Delft-FEWS with different hydrological, hydraulic, and reservoir models, etc. Last, several cases studies and applications of Delft-FEWS will be demonstrated, including the National Weather Service and the Bonneville Power Administration in USA, and a national application in the water board in the Netherland.

  18. Clashes of discourses: Humanists and Calvinists in seventeenth-century academic Leiden

    NARCIS (Netherlands)

    Kromhout, D.

    2016-01-01

    Using Michel Foucault's concept of discursive change and Stephen Greenblatt's ideas about social poetics and self-fashioning, 'Clashes of Discourses: Calvinists and Humanists in Seventeenth-Century Academic Leiden' explains developments in the literary works of leading Leiden humanists against the

  19. Progression and regression of atherosclerosis in APOE3-Leiden transgenic mice : An immunohistochemical study

    NARCIS (Netherlands)

    Gijbels, M.J.J.; Cammen, M. van der; Laan, L.J.W. van der; Emeis, J.J.; Havekes, L.M.; Hofker, M.H.; Kraal, G.

    1999-01-01

    Apolipoprotein E3-Leiden (APOE3-Leiden) transgenic mice develop hyperlipidemia and are highly susceptible to diet-induced atherosclerosis. We have studied the progression and regression of atherosclerosis using immunohistochemistry. Female transgenic mice were fed a moderate fat diet to study

  20. Scavenger receptor deficiency leads to more complex atherosclerotic lesions in APOE3Leiden transgenic mice

    NARCIS (Netherlands)

    Winther, M.P.J. de; Gijbels, M.J.J.; Dijk, K.W. van; Gorp, P.J.J. van; Suzuki, H.; Kodama, T.; Frants, R.R.; Havekes, L.M.; Hofker, M.H.

    1999-01-01

    Apolipoprotein (apo) E3Leiden is a dysfunctional apo E variant associated with familial dysbetalipoproteinemia in humans. Transgenic mice carrying the APOE3Leiden gene develop hyperlipidemia and are highly susceptible to diet-induced atherosclerosis. An early step in atherosclerosis is foam cell

  1. Weldenkende burgers en Oranjeliefhebbers. Patriotten en Prinsgezinden in Leiden, 1775-1795

    NARCIS (Netherlands)

    de Jong, E.H.

    2014-01-01

    This book deals with the conflicts between Patriots and Orangists in Leiden, which will be assessed with the help of the theory of collective action by the American sociologist Charles Tilly. The urban economy in Leiden was dominated by a textile industry that concentrated on exports and was very

  2. Delft Dashboard: a quick setup tool for coastal and estuarine models

    Science.gov (United States)

    Nederhoff, C., III; Van Dongeren, A.; Van Ormondt, M.; Veeramony, J.

    2016-02-01

    We developed easy-to-use Delft DashBoard (DDB) software for the rapid set-up of coastal and estuarine hydrodynamic and basic morphological numerical models. In the "Model Maker" toolbox, users have the capability to set-up Delft3D models, in a minimal amount of time (in the order of a hour), for any location in the world. DDB draws upon public internet data sources of bathymetry and tidesto construct the model. With additional toolboxes, these models can be forced with parameterized hurricane wind fields, uplift of the sea surface due to tsunamis nested in publically available ocean models and forced with meteo data (wind speed, pressure, temperature) In this presentation we will show the skill of a model which is setup with Delft Dashboard and compare it to well-calibrated benchmark models. These latter models have been set-up using detailed input data and boundary conditions. We have tested the functionality of Delft DashBoard and evaluate the performance and robustness of the DDB model system on a variety of cases, ranging from a coastal to basin models. Furthermore, we have performed a sensitivity study to investigate the most critical physical and numerical processes. The software can benefit operational modellers, as well as scientists and consultants.

  3. English Language Screening for Scientific Staff at Delft University of Technology,

    NARCIS (Netherlands)

    Klaassen, R.G.; Bos, M.H.P.C.

    2010-01-01

    Delft University of Technology (DUT) screened her (non-native English) scientific staff on their level of English proficiency in the academic year of 2006/2007. In this paper this large scale operation, involving planning, policy decisions, assessment means, advice and training are discussed. Since

  4. Hop, Step, Step and Jump : Towards Real-World Complexity @ Delft University of Technology

    NARCIS (Netherlands)

    Pruyt, E.; Slinger, J.H.; Van Daalen, C.; Yucel, G.; Thissen, W.A.H.

    2009-01-01

    This paper deals with System Dynamics education at Delft University of Technology, the Netherlands. It focuses more specifically on the quadruple jump approach towards dealing with real-world dynamic complexity. The paper starts with an overview of the System Dynamics courses, situated within the

  5. Essential Skills for System Dynamics Practitioners : A Delft University of Technology Perspective

    NARCIS (Netherlands)

    Meyers, W.K.; Slinger, J.H.; Pruyt, E.; Yucel, G.; Van Daalen, C.

    2010-01-01

    There is little consensus on the skills set required of a system dynamics practitioner. In this paper we use the teaching approach and learning goals of the system dynamics courses at the Delft University of Technology as a starting point to explore the development of system dynamics modeling

  6. The trail of six design projects in the Delft bachelor Aerospace Engineering

    NARCIS (Netherlands)

    Kamp, A.

    2012-01-01

    Tomorrow’s engineers are required to have a good balance between deep working knowledge of engineering sciences and engineering skills. In the Bachelor Aerospace Engineering at TU Delft, students are educated to master these competences so that they are ready to engineer when they graduate. The

  7. You can't just blame the crocodile : Delft engineers travel into sustainability

    NARCIS (Netherlands)

    Van der Sanden, M.C.A., et al

    2007-01-01

    This book contains stories of young people who made a journey into sustainability. It is about engineers from TU Delft and the inspiration they derived from the people they met and the projects they have seen throughout the world. It is about construction, sanitation, mobile networks,

  8. Antony van Leeuwenhoek's microscopes and other scientific instruments: new information from the Delft archives

    NARCIS (Netherlands)

    Zuidervaart, Huib J.

    2016-01-01

    This paper discusses the scientific instruments made and used by the microscopist Antony van Leeuwenhoek (1632–1723). The immediate cause of our study was the discovery of an overlooked document from the Delft archive: an inventory of the possessions that were left in 1745 after the death of

  9. One Thousand Flowers in Delft: A Bottom-up approach to improve teaching international students

    NARCIS (Netherlands)

    Brummelink, M.L.; Frantzeskaki, N.; Klaassen, R.G.; Blom, E.M.; Kooij, R.E.; Kroesen, J.O.; Stadler D.I.; Boogaard, M.E.D. van den

    2009-01-01

    Delft University of Technology (DUT) is becoming more and more an international community. Since lectures on master level are all conducted in English, the numbers of students from foreign countries attending DUT are rising and international cooperation within educational projects is a necessity. To

  10. One Thousand Flowers in Delft : A Bottom-up approach to improve teaching international students

    NARCIS (Netherlands)

    Brummelink, M.L.; Frantzeskaki, N.; Klaassen, R.G.; Blom, E.M.; Kooij, R.E.; Kroesen, J.O.; Stadler, D.I.; Van den Boogaard, M.E.D.

    2009-01-01

    Delft University of Technology (DUT) is becoming more and more an international community. Since lectures on master level are all conducted in English, the numbers of students from foreign countries attending DUT are rising and international cooperation within educational projects is a necessity. To

  11. Creating the integral engineer : Combining development education, sustainability, entrepreneurship and technology at Delft University of Technology

    NARCIS (Netherlands)

    Zwarteveen, J.W.; Blom, E.M.; Vastbinder, B.; Brezet, J.C.

    2010-01-01

    A modern engineer is more than a technical specialist. Training an integral engineer requires education in non-technical skills, including social and ethical aspects. Therefore, Delft University of Technology (DUT) introduced sustainable development and entrepreneurship into its bachelor and master

  12. Teaching Sustainable Entrepreneurship to Engineering Students: The Case of Delft University of Technology

    Science.gov (United States)

    Bonnet, Hans; Quist, Jaco; Hoogwater, Daan; Spaans, Johan; Wehrmann, Caroline

    2006-01-01

    Sustainability, enhancement of personal skills, social aspects of technology, management and entrepreneurship are of increasing concern for engineers and therefore for engineering education. In 1996 at Delft University of Technology this led to the introduction of a subject on sustainable entrepreneurship and technology in the course programmes of…

  13. Dirc van Delfts Tafel van den Kersten Ghelove en de stervensliteratuur

    DEFF Research Database (Denmark)

    Robbe, Joost Roger

    2015-01-01

    treatise, Dirc van Delft presents a veritable ars moriendi which provides practical guidance for the dying and those attending them. The treatise culminates in a vivid drama in which the soul, being subject to three temptations of the devil, can benefit from the protection of its guardian angel as well...

  14. Factor V Leiden is associated with increased sperm count

    DEFF Research Database (Denmark)

    van Mens, T E; Joensen, U N; Bochdanovits, Z

    2017-01-01

    STUDY QUESTION: Is the thrombophilia mutation factor V Leiden (FVL) associated with an increased total sperm count? SUMMARY ANSWER: Carriers of FVL have a higher total sperm count than non-FVL-carriers, which could not be explained by genetic linkage or by observations in a FVL-mouse model. WHAT...... IS KNOWN ALREADY: FVL has a high prevalence in Caucasians despite detrimental health effects. Carriers have been shown to have higher fecundity, which might partly explain this evolutionary paradox. STUDY DESIGN, SIZE, DURATION: We determined FVL status in two cohorts (Dutch, n = 627; Danish, n = 854....... There were differences in smoking, abstinence time and age between the cohorts. We corrected for these in the primary analysis, which consisted of a mixed linear effects model, also incorporating unobjectified population differences. In public haplotype data from subjects of European descent, we explored...

  15. Indigenous Peoples: Local Impacts of International Rights. Valedictory Lecture Leiden University

    OpenAIRE

    Persoon, G.A.

    2017-01-01

    Valedictory lecture given by Prof.dr. Gerard A. Persoon Professor of Environment and Development and in particular Indigenous Peoples in Southeast Asia at Leiden University on Monday, October 23 2017Museum Volkenkunde / Ethnographic Museum

  16. Gewenst beleid tegen ongewenst gedrag : onveiligheid binnen de organisatie kan leiden tot ziekteverzuim

    NARCIS (Netherlands)

    Dalen, E.J. van; Nuyens, M.

    2005-01-01

    Indimidatie en agressie en geweld op het werk kunnen leiden tot gevoelens van onveiligheid en ziekteverzuim. Bepalingen in de Arbowet hebben onvoldoende effect op beleidsvorming ter voorkoming van ongewenste omgangsvormen. Goede praktijkvoorbeelden van beleid tegen ongewenst gedrag kunnen

  17. Indigenous Peoples : Local Impacts of International Rights. Valedictory Lecture Leiden University

    NARCIS (Netherlands)

    Persoon, G.A.

    2017-01-01

    Valedictory lecture given by Prof.dr. Gerard A. Persoon Professor of Environment and Development and in particular Indigenous Peoples in Southeast Asia at Leiden University on Monday, October 23 2017Museum Volkenkunde / Ethnographic Museum

  18. Push or Pull Students into Blended Education A Case Study at Delft University of Technology

    OpenAIRE

    Cervone, A.; Melkert, J.A.; Mebus, L.F.M.; Saunders, G.N.

    2016-01-01

    Blended education, or “flipping the classroom” is rapidly becoming a mainstream form of teaching within universities. Within Engineering Education, it is popular as it allows more time in-class to focus on hands on activities such as demonstrations and solving complex problems. This paper discusses the effort conducted to restructure, according to the blended learning principles, the “Propulsion and Power” course of the Aerospace Engineering Bachelor degree programme at Delft University of Te...

  19. Delft3D turbine turbulence module v. 1.0.0

    Energy Technology Data Exchange (ETDEWEB)

    2016-08-25

    The DOE has funded Sandia National Labs (SNL) to develop an open-source modeling tool to guide the design and layout of marine hydrokinetic (MHK) arrays to maximize power production while minimizing environmental effects. This modeling framework simulates flows through and around a MHK arrays while quantifying environmental responses. As an augmented version of the Dutch company, Deltares’s, environmental hydrodynamics code, Delft3D, Delft3D-CEC includes a new module that simulates energy conversion (momentum withdrawal) by MHK current energy conversion devices with commensurate changes in the turbulent kinetic energy and its dissipation rate. The Following is a description of Deltares’s open-source code Delft3D from which Delft3D-CEC is built upon. “Delft3D is a world leading 3D modeling suite to investigate hydrodynamics, sediment transport and morphology and water quality for fluvial, estuarine and coastal environments. As per 1 January 2011, the Delft3D flow (FLOW), morphology (MOR) and waves (WAVE) modules are available in open source. The software is used and has proven his capabilities on many places around the world, like the Netherlands, USA, Hong Kong, Singapore, Australia, Venice, etc. The software is continuously improved and developed with innovating advanced modelling techniques as consequence of the research work of our institute and to stay world leading. The FLOW module is the heart of Delft3D and is a multi-dimensional (2D or 3D) hydrodynamic (and transport) simulation programme which calculates non-steady flow and transport phenomena resulting from tidal and meteorological forcing on a curvilinear, boundary fitted grid or sperical coordinates. In 3D simulations, the vertical grid is defined following the so-called sigma coordinate approach or Z-layer approach. The MOR module computes sediment transport (both suspended and bed total load) and morphological changes for an arbitrary number of cohesive and non-cohesive fractions. Both currents

  20. Ethics and engineering courses at Delft University of Technology: contents, educational setup and experiences.

    Science.gov (United States)

    van de Poel, I R; Zandvoort, H; Brumsen, M

    2001-04-01

    This article reports on the development and teaching of compulsory courses on ethics and engineering at Delft University of Technology (DUT). Attention is paid to the teaching goals, the educational setup and methods, the contents of the courses, involvement of staff from engineering schools, experiences to date, and challenges for the future. The choices made with respect to the development and teaching of the courses are placed within the European and Dutch context and are compared and contrasted with the American situation and experiences.

  1. Reconstructing the Middle Ages. Dirck van Bleyswijck’s Beschryvinge der stadt Delft and its uneasy relationship with the past

    Directory of Open Access Journals (Sweden)

    Marcin Polkowski

    2013-12-01

    Full Text Available Dirck van Bleyswijck's Beschryvinge der stadt Delft presents an ambiguous and problematic attitude to the medieval history of Delft, which makes it interesting to scholars wishing to explore the perception of the Middle Ages as it crystallized during the early modern period. The aim of this contribution is to determine the intellectual origins of Van Bleyswijck's work as a historian in the context of his perception of the medieval past. The analysis of Van Bleyswijck's performance as a historian is based on a case study derived from the narrative: quotations from source texts and commentary about the life of the medieval Delft beguine Geertruyd van Oosten will be compared. Van Bleyswijck's representation of the Middle Ages was formed by a combination of humanist and proto-Enlightenment concepts, which entailed a critical reaction to forms of religious culture known to medieval society.

  2. Prevalentie van chronische-vermoeidheidsyndroom in 4 huisartspraktijken in de regio Leiden [Prevalence of chronic fatigue syndrome in four general practices in Leyden region

    NARCIS (Netherlands)

    Versluis, R.G.J.A.; Waal, M.W.M. de; Opmeer, C.; Petri, H.; Springer, M.P.

    1997-01-01

    Doel. De prevalentie vaststellen van chronische-vermoeidheidsyndroom (CVS) in de huisartspraktijk. Opzet. Descriptief. Plaats. Huisartspraktijken in Leiden en omstreken. Methode. Het geanonimiseerde geautomatiseerde databestand van het Registratie Netwerk Universitaire Huisartspraktijken Leiden en

  3. IAEA Activities in Nuclear Security, 18 April 2013, Delft, The Netherlands

    International Nuclear Information System (INIS)

    Amano, Y.

    2013-01-01

    I am pleased to take part in this event marking the launch of the new Masters Programme in Nuclear Security at the Reactor Institute Delft. The Institute has been an IAEA Collaborating Centre for nearly four years. Our two organisations have worked closely together in training and research, as well as in areas such as establishing quality management systems at nuclear analytical laboratories in IAEA Member States. The launch of the new Masters Programme in Nuclear Security by the Delft University of Technology marks a new stage in our cooperation. Four other European universities are also taking part in the programme: the University of Oslo, the Technical University of Vienna, the Brandenburg University of Applied Sciences, and the University of Manchester Dalton Nuclear Institute. I am pleased that the syllabus for the course has been developed from the IAEA's Educational Programme in Nuclear Security. I commend this effort to train a new generation of experts who can help to improve global nuclear security. Strengthening nuclear security throughout the world remains a challenge for all of us. National governments have primary responsibility for nuclear security, but international cooperation is vital.

  4. Differential effects of amlodipine and atorvastatin treatment and their combination on atherosclerosis in ApoE*3-Leiden transgenic mice

    NARCIS (Netherlands)

    Delsing, D.J.; Jukema, J.W.; van de Wiel, M.A.; Emeis, J.; van der Laarse, A.; Havekes, L.M.; Princen, H.M.G.

    2003-01-01

    This study was designed to investigate the potential antiatherosclerotic effects of the calcium antagonist amlodipine as compared with the HMG-CoA reductase inhibitor atorvastatin and the combination of both in ApoE*3-Leiden transgenic mice. Four groups of 15 ApoE*3-Leiden mice were put on a

  5. Factor V Leiden is associated with increased sperm count.

    Science.gov (United States)

    van Mens, T E; Joensen, U N; Bochdanovits, Z; Takizawa, A; Peter, J; Jørgensen, N; Szecsi, P B; Meijers, J C M; Weiler, H; Rajpert-De Meyts, E; Repping, S; Middeldorp, S

    2017-11-01

    Is the thrombophilia mutation factor V Leiden (FVL) associated with an increased total sperm count? Carriers of FVL have a higher total sperm count than non-FVL-carriers, which could not be explained by genetic linkage or by observations in a FVL-mouse model. FVL has a high prevalence in Caucasians despite detrimental health effects. Carriers have been shown to have higher fecundity, which might partly explain this evolutionary paradox. We determined FVL status in two cohorts (Dutch, n = 627; Danish, n = 854) of consecutively included men without known causes for spermatogenic failure, and performed an individual patient data meta-analysis of these two cohorts together with one previously published (Dutch, n = 908) cohort. We explored possible biological underpinnings for the relation between sperm count and FVL, by use of a FVL-mouse model and investigations of genetic linkage. Participants were male partners of subfertile couples (two Dutch cohorts) and young men from the general population (Danish cohort): FVL carrier rate was 4.0%, 4.6% and 7.3%, respectively. There were differences in smoking, abstinence time and age between the cohorts. We corrected for these in the primary analysis, which consisted of a mixed linear effects model, also incorporating unobjectified population differences. In public haplotype data from subjects of European descent, we explored linkage disequilibrium of FVL with all known single nucleotide polymorphisms in a 1.5 MB region around the F5 gene with an R2 cutoff of 0.8. We sequenced exons of four candidate genes hypothesized to be linked to FVL in a subgroup of FVL carriers with extreme sperm count values. The animal studies consisted of never mated 15-18-week-old C57BL/J6 mice heterozygous and homozygous for FVL and wild-type mice. We compared spermatogenesis parameters (normalized internal genitalia weights, epididymis sperm content and sperm motility) between FVL and wild-type mice. Human FVL carriers have a higher total sperm

  6. Increased sperm count may account for high population frequency of factor V Leiden

    NARCIS (Netherlands)

    Cohn, D. M.; Repping, S.; Büller, H. R.; Meijers, J. C. M.; Middeldorp, S.

    2010-01-01

    Background: Factor V Leiden (FVL) increases the risk of venous thrombosis and pregnancy loss in carriers. Nevertheless, this relatively old mutation is prevalent in Caucasion populations, which could be explained by positive selection pressure. Men with FVL have previously been found to have higher

  7. CETP does not affect triglyceride production or clearance in APOE*3-Leiden mice

    NARCIS (Netherlands)

    Bijland, S.; Berg, S.A.A. van den; Voshol, P.J.; Hoek, A.M. van den; Princen, H.M.G.; Havekes, L.M.; Rensen, P.C.N.; Dijk, K.W. van

    2010-01-01

    The cholesteryl ester transfer protein (CETP) facilitates the bidirectional transfer of cholesteryl esters and triglycerides (TG) between HDL and (V)LDL. By shifting cholesterol in plasma from HDL to (V)LDL in exchange for VLDL-TG, CETP aggravates atherosclerosis in hyperlipidemic APOE*3-Leiden

  8. Mistaken Identity and Mirror Images: Albert and Carl Einstein, Leiden and Berlin, Relativity and Revolution

    NARCIS (Netherlands)

    van Dongen, J.A.E.F.

    2012-01-01

    Albert Einstein accepted a “special” visiting professorship at the University of Leiden in the Netherlands in February 1920. Although his appointment should have been a mere formality, it took until October of that year before Einstein could occupy his special chair. Why the delay? The explanation

  9. History and highlights of the teratological collection in the Museum Anatomicum of Leiden University, The Netherlands

    NARCIS (Netherlands)

    Boer, Lucas L.; Boek, Peter L. J.; van Dam, Andries J.; Oostra, Roelof-Jan

    2018-01-01

    The anatomical collection of the Anatomical Museum of Leiden University Medical Center (historically referred to as Museum Anatomicum Academiae Lugduno-Batavae) houses and maintains more than 13,000 unique anatomical, pathological and zoological specimens, and include the oldest teratological

  10. Orthopterological notes I : On the Lesini of the Leiden Museum (Tettigoniidae, Copiphorinae)

    NARCIS (Netherlands)

    Jong, de C.

    1942-01-01

    When rearranging a part of the collections of Orthoptera in the Rijksmuseum van Natuurlijke Historie at Leiden I found a number of specimens belonging to this tribus, which by former authors is considered as a separate subfamily with the name Eumegalodontinae (Kirby, 1906, p. 289; Caudell, 1927, p.

  11. PXR agonism decreases plasma HDL levels in ApoE*3-Leiden.CETP mice

    NARCIS (Netherlands)

    Haan, W. de; Vries-van der Weij, J. de; Mol, I.M.; Hoekstra, M.; Romijn, J.A.; Jukema, J.W.; Havekes, L.M.; Princen, H.M.G.; Rensen, P.C.N.

    2009-01-01

    Pregnane X receptor (PXR) agonism has been shown to affect multiple steps in both the synthesis and catabolism of HDL, but its integrated effect on HDL metabolism in vivo remains unclear. The aim of this study was to evaluate the net effect of PXR agonism on HDL metabolism in ApoE*3-Leiden (E3L) and

  12. Verzeichnis der Echiuridae, Sipunculidae und Priapulidae des Naturhistorichen Reichsmuseums in Leiden

    NARCIS (Netherlands)

    Stiasny, G.

    1930-01-01

    Die vorliegende Mitteilung ist das Ergebnis der Bearbeitung zumeist älteren Materiales an Echiuriden, Sipunculiden und Priapuliden des Naturhistorischen Reichs-Museums in Leiden. Obwohl die Sammlung nach Anzahl der Exemplare nicht umfangreich ist, zeigt sie einen überraschenden Reichtum an Formen

  13. Subacute Budd-Chiari syndrome associated with polycythemia vera and factor V Leiden mutation

    NARCIS (Netherlands)

    Simsek, S; Verheesen, RV; Haagsma, EB; Lourens, J

    We describe a 48-year-old caucasian woman with a subacute Budd-Chiari syndrome attributed to the presence of polycythaemia vera, heterozygosity for the factor V Leiden mutation and the use of an oral contraceptive pill. Two diagnostic pitfalls were encountered. First, on CT scanning of the abdomen

  14. The Association of Factor V Leiden Mutation with Recurrent Pregnancy Loss

    International Nuclear Information System (INIS)

    Kashif, M.; Saeed, A.

    2015-01-01

    Objective: To determine the association of factor V Leiden mutation with recurrent pregnancy loss. Methods: The case-control study was conducted at the Department of Haematology, Armed Forces Institute of Pathology, Rawalpindi, Pakistan, from January to June 2012, and comprised women of 18 to 45 years of age who had a history of recurrent pregnancy loss, and controls with no history of pregnancy loss. All the subjects belonged to Punjabi ethnic group. Three ml blood was taken from cases and controls and deoxyribonucleic acid was extracted. In order to identify Factor V Leiden mutation, polymerase chain reaction method was utilised combined with the amplification refractory mutation system. Data was analysed using SPSS 17. Results: Of the 112 subjects, 56(50 percent) were in each of the two groups. The presence of factor V Leiden mutation among the cases was 3(5.4 percent) while it was absent among the controls. The mutation was significantly associated with recurrent pregnancy loss (p=0.017).Recurrent pregnancy loss was higher in cases than controls (p=0.001). Conclusion: Factor V Leiden mutation was significantly associated with recurrent pregnancy loss. It should be considered one of the causes of recurrent pregnancy loss. (author)

  15. On some Hymenoptera from the collection of Guerin-Méneville in the Leiden museum

    NARCIS (Netherlands)

    Vecht, van der J.

    1957-01-01

    About thirty years ago, while studying the Sphecinae of the Leiden Museum, I found two species of Sphex, described by F. E. Guérin-Méneville, represented here by specimens originating from the collection of this author. A note on these species, Sphex lanierii Guérin and Sphex paulinieri Guérin, was

  16. Plasma hepcidin levels and anemia in old age. The Leiden 85-Plus Study

    NARCIS (Netherlands)

    Elzen, W.P. den; Craen, A.J. de; Wiegerinck, E.T.G.; Westendorp, R.G.J.; Swinkels, D.W.; Gussekloo, J.

    2013-01-01

    Hepcidin, an important regulator of iron homeostasis, is suggested to be causally related to anemia of inflammation. The aim of this study was to explore the role of plasma hepcidin in anemia among older persons from the general population. The Leiden 85-Plus Study is a population-based study of

  17. Die Scyphomedusen-Sammlung des Naturhistorischen Reichsmuseums in Leiden : II. Stauromedusae, Coronatae, Semaeostomeae

    NARCIS (Netherlands)

    Stiasny, G.

    1919-01-01

    ALLGEMEINER TEIL. Die Bearbeitung der umfangreichen Scyphomedusen-Sammlung im Rijksmuseum van Natuurlijke Historie in Leiden ist nunmehr so weit vorgeschritten, dass sich eine Übersicht über dieselbe gewinnen lässt. In einer früheren Mitteilung wurde über die Cubomedusen berichtet, eine weitere zur

  18. A half century of abstracting at the African Studies Centre Leiden

    NARCIS (Netherlands)

    Doorn, van M.C.A.

    2013-01-01

    The article discusses the history of the abstracts and indexing journal originally known as 'Documentatieblad,' which was renamed to 'African Studies Abstracts (ASA)' and later to 'African Studies Abstracts Online' (ASAO), published by the African Studies Centre (ASC) in Leiden, the Netherlands

  19. Distribution of some hydrocarbons in ambient air near Delft and the influence on the formation of secondary air pollutants

    NARCIS (Netherlands)

    Bos, R.; Guicherit, R.; Hoogeveen, A.

    1977-01-01

    The relative concentrations of hydrocarbons in the atmosphere may provide information concerning their origin. It appears that the hydrocarbon composition measured in Delft (The Netherlands) is entirely different for northern and southern wind directions. This points to different sources. The most

  20. [R]MIT Research Centre at Delft University of Technology: A Bridge between Research, Education, Society and Profession

    Science.gov (United States)

    Zijlstra, Hielkje

    2009-01-01

    In 2006, we launched the [R]MIT Research Centre (Modification, Intervention Transformation) at the Faculty of Architecture at Delft University of Technology. [R]MIT was founded to respond to the need for an integrated, multi-disciplinary approach to the transformation of the built environment. [R]MIT aims to bring momentum to the renewal of…

  1. Collaboration of the Dutch research program for radioactive waste disposal (OPERA) and TU Delft

    Energy Technology Data Exchange (ETDEWEB)

    Bykov, D.M.; Kloosterman, J.L. [TU Delft (Netherlands). Reactor Inst. Delft; Neeft, E.A.C.; Verhoef, E.V. [COVRA N.V., Nieuwdorp (Netherlands)

    2015-07-01

    awarded research proposals available at www.covra.nl/downloads/o pera. Building up competences and knowledge on radioactive waste management and geological disposal is an important goal of OPERA. To this end OPERA collaborates with TU Delft to develop an academic curriculum for the chair Chemistry of the Nuclear Fuel Cycle in the Master of Science Engineering. Furthermore, the results obtained in OPERA will be presented at a Summer School which is planned to be organized at the end of the Program. TU Delft educates young specialists, bachelor and master students, by research projects on geological disposal at the new actinide laboratory (U and Th). For such purpose the knowledge transfer from other OPERA partners is also foreseen, including students internships and visits of the research facilities. Reactor Institute Delft (RID) is part of the Applied Sciences faculty of TU Delft and houses the Radiation Science and Technology (RST) department. RID operates the Hoger Onderwijs Reactor (HOR), a 2 MW pool- type research reactor in an academic setting. The reactor is used as a source of neutrons and positrons for research purposes, including those of OPERA. It also provides neutrons to a variety of facilities for radioisotope production and neutron activation analysis. OPERA is financed by the Dutch Ministry of Economic Affairs and the public limited liability company Elektriciteits-Produktiemaatschappij Zuid-Nederland (EPZ) and coordinated by COVRA.

  2. Collaboration of the Dutch research program for radioactive waste disposal (OPERA) and TU Delft

    International Nuclear Information System (INIS)

    Bykov, D.M.; Kloosterman, J.L.

    2015-01-01

    awarded research proposals available at www.covra.nl/downloads/o pera. Building up competences and knowledge on radioactive waste management and geological disposal is an important goal of OPERA. To this end OPERA collaborates with TU Delft to develop an academic curriculum for the chair Chemistry of the Nuclear Fuel Cycle in the Master of Science Engineering. Furthermore, the results obtained in OPERA will be presented at a Summer School which is planned to be organized at the end of the Program. TU Delft educates young specialists, bachelor and master students, by research projects on geological disposal at the new actinide laboratory (U and Th). For such purpose the knowledge transfer from other OPERA partners is also foreseen, including students internships and visits of the research facilities. Reactor Institute Delft (RID) is part of the Applied Sciences faculty of TU Delft and houses the Radiation Science and Technology (RST) department. RID operates the Hoger Onderwijs Reactor (HOR), a 2 MW pool- type research reactor in an academic setting. The reactor is used as a source of neutrons and positrons for research purposes, including those of OPERA. It also provides neutrons to a variety of facilities for radioisotope production and neutron activation analysis. OPERA is financed by the Dutch Ministry of Economic Affairs and the public limited liability company Elektriciteits-Produktiemaatschappij Zuid-Nederland (EPZ) and coordinated by COVRA.

  3. The Prebiotic Inulin Aggravates Accelerated Atherosclerosis in Hypercholesterolemic APOE*3-Leiden Mice

    OpenAIRE

    Lisa R. Hoving; Margreet R. de Vries; Rob C. M. de Jong; Saeed Katiraei; Amanda Pronk; Paul H. A. Quax; Vanessa van Harmelen; Ko Willems van Dijk

    2018-01-01

    The prebiotic inulin has proven effective at lowering inflammation and plasma lipid levels. As atherosclerosis is provoked by both inflammation and hyperlipidemia, we aimed to determine the effect of inulin supplementation on atherosclerosis development in hypercholesterolemic APOE*3-Leiden (E3L) mice. Male E3L mice were fed a high-cholesterol (1%) diet, supplemented with or without 10% inulin for 5 weeks. At week 3, a non-constrictive cuff was placed around the right femoral artery to induce...

  4. Ein Werther der DDR : Plenzdorfs Neue Leiden des jungen W. im gespaltenen Deutschland

    OpenAIRE

    Jäger, Georg

    2009-01-01

    Die neuen Leiden des jungen W. wurden »bewußt auf Auslegbarkeit geschrieben« und irritierten die Kritiker durch »die ungeheure Breite der Assoziationsmöglichkeiten«. Durch die vier »strukturtragenden Schichten« oder Informationsebenen des Textes kommt es zu interferierenden Perspektiven: 1. die voranstehenden Dokumente (Zeitungsnotiz, drei Todesanzeigen), 2. »die szenisch-dialogisch objektivierte Erinnerungsperspektive der Eltern und Arbeitskollegen«, 3. die Kommentare Edgars »von jenseits de...

  5. Human Diversity : Design for life: 9th International Congress of Physiological Anthropology: Proceedings, Delft, The Netherlands, 22-26 August 2008

    NARCIS (Netherlands)

    Louts, T.; Reitenbach, M.E.F.R.; Molenbroek, J.F.M.

    2009-01-01

    This book of full papers contains the proceedings of the ICPA (International Congress of Physiological Anthropology) conference, held at the faculty of Industrial Design Engineering, TU Delft, from 22-26 August 2008.

  6. Sandia’s Current Energy Conversion module for the Flexible-Mesh Delft3D flow solver v. 1.0

    Energy Technology Data Exchange (ETDEWEB)

    2018-04-25

    The DOE has funded Sandia National Labs (SNL) to develop an open-source modeling tool to guide the design and layout of marine hydrokinetic (MHK) arrays to maximize power production while minimizing environmental effects. This modeling framework simulates flows through and around a MHK arrays while quantifying environmental responses. As an augmented version of the Dutch company, Deltares’s, environmental hydrodynamics code, Delft3D, SNL-Delft3D-CEC-FM includes a new module that simulates energy conversion (momentum withdrawal) by MHK current energy conversion devices with commensurate changes in the turbulent kinetic energy and its dissipation rate. SNL-Delft3D-CEC-FM modified the Delft3D flexible mesh flow solver, DFlowFM.

  7. Technische universiteiten en duurzame ontwikkeling in Afrika : Een interfacultair studenten onderzoeksproject voor het 33e lustrumsymposium van de Technische Universiteit Delft

    NARCIS (Netherlands)

    Duijvestein, C.A.J.; de Vries, G.; Bos, M.; Cozijnse, K.; Findlater, J.W.; Fremouw, M.; Jonkman, J.; Oijevaar, K.; Peters, S.; van Rattinghe, K.; Sack-van Straaten, K.; De Vries, G.; Wessels, R.

    2007-01-01

    In 2007, Delft University of Technology celebrates its 165th birthday. This unique occasion is celebrated with several activities revolving around the subject "Sustainable Solutions, with a focus on Africa". For the interdisciplinary course "Technical Universities and Sustainable development of

  8. Gas concentration and temperature in acoustically excited Delft turbulent jet flames

    Energy Technology Data Exchange (ETDEWEB)

    Ana Maura A. Rocha; Joao A. Carvalho Jr.; Pedro T. Lacava [Sao Paulo State University, Guaratingueta (Brazil)

    2008-11-15

    This paper shows the experimental results for changes in the flame structure when acoustic fields are applied in natural gas Delft turbulent diffusion flames. The acoustic field (pulsating combustion) generates zones of intense mixture of reactants in the flame region, promoting a more complete combustion and, consequently, lower pollutant emissions, increase in convective heat transfer rates, and lower fuel consumption. The results show that the presence of the acoustic field changes drastically the flame structure, mainly in the burner natural frequencies. However, for higher acoustic amplitudes, or acoustic pressures, a hydrogen pilot flame is necessary in order to keep the main flame anchored. In the flame regions where the acoustic field is more intense, premixed flame characteristics were observed. Besides, the pulsating regime modifies the axial and radial combustion structure, which could be verified by the radial distribution of concentrations of O{sub 2}, CO, CO{sub 2}, and NOx, and by the temperature profile. The experiments also presented the reduction of flame length with the increase of acoustic amplitude. 30 refs., 15 figs., 3 tabs.

  9. Green micro-resistojet research at Delft University of Technology: new options for Cubesat propulsion

    Science.gov (United States)

    Cervone, A.; Zandbergen, B.; Guerrieri, D. C.; De Athayde Costa e Silva, M.; Krusharev, I.; van Zeijl, H.

    2017-03-01

    The aerospace industry is recently expressing a growing interest in green, safe and non-toxic propellants for the propulsion systems of the new generation of space vehicles, which is especially true in the case of Cubesat micro-propulsion systems. Demanding requirements are associated to the future missions and challenges offered by this class of spacecraft, where the availability of a propulsion system might open new possibilities for a wide range of applications including orbital maintenance and transfer, formation flying and attitude control. To accomplish these requirements, Delft University of Technology is currently developing two different concepts of water-propelled micro-thrusters based on MEMS technologies: a free molecular micro-resistojet operating with sublimating solid water (ice) at low plenum gas pressure of less than 600 Pa, and a more conventional micro-resistojet operating with liquid water heated and vaporized by means of a custom designed silicon heating chamber. In this status review paper, the current design and future expected developments of the two micro-propulsion concepts is presented and discussed, together with an initial analysis of the expected performance and potential operational issues. Results of numerical simulations conducted to optimize the design of the heating and expansion slots, as well as a detailed description of the manufacturing steps for the conventional micro-resistojet concept, are presented. Some intended steps for future research activities, including options for thrust intensity and direction control, are briefly introduced.

  10. Nuclear Science and Engineering education at the Delft University of Technology

    International Nuclear Information System (INIS)

    Bode, P.

    2009-01-01

    There is a national awareness in the Netherlands for strengthening education in the nuclear sciences, because of the ageing workforce, and to ensure competence as acceptability increases of nuclear power as an option for diversification of the energy supply. This may be reflected by the rapidly increasing number of students at the Delft University of Technology with interest in nuclear science oriented courses, and related bachelor and MSc graduation projects. These considerations formed the basis of the Nuclear Science and Engineering concentration, effectively starting in 2009. The programme can be taken as focus of the Research and Development Specialisation within the Master Programme in Applied Physics or as a Specialisation within the Master's Programme in Chemical Engineering. Both programmes require successful completion of a total of 120 ECTS study points, consisting of two academic years of 60 ECTS (1680 hours of study). Of that total, 100 ECTS are in the field of Nuclear Science and Engineering, depending on students choices within the programme, including a (industrial) internship, to be taken in companies all over the world. In Chemical Engineering, there is a compulsory design project during which a product or process should be developed. Both programmes also require a final graduation project. In both curricula, Nuclear Science and Engineering comprises compulsory and elective courses, which allow students to focus on either health or energy. Examples of courses include Nuclear Science, Nuclear Chemistry, Nuclear Engineering, Reactor Physics, Chemistry of the Nuclear Fuel Cycle, Medical Physics and Radiation Technology and Radiological Health Physics. (Author)

  11. Filtration Characterization Method as Tool to Assess Membrane Bioreactor Sludge Filterability—The Delft Experience

    Directory of Open Access Journals (Sweden)

    Maria Lousada-Ferreira

    2014-04-01

    Full Text Available Prevention and removal of fouling is often the most energy intensive process in Membrane Bioreactors (MBRs, responsible for 40% to 50% of the total specific energy consumed in submerged MBRs. In the past decade, methods were developed to quantify and qualify fouling, aiming to support optimization in MBR operation. Therefore, there is a need for an evaluation of the lessons learned and how to proceed. In this article, five different methods for measuring MBR activated sludge filterability and critical flux are described, commented and evaluated. Both parameters characterize the fouling potential in full-scale MBRs. The article focuses on the Delft Filtration Characterization method (DFCm as a convenient tool to characterize sludge properties, namely on data processing, accuracy, reproducibility, reliability, and applicability, defining the boundaries of the DFCm. Significant progress was made concerning fouling measurements in particular by using straight forward approaches focusing on the applicability of the obtained results. Nevertheless, a fouling measurement method is still to be defined which is capable of being unequivocal, concerning the fouling parameters definitions; practical and simple, in terms of set-up and operation; broad and useful, in terms of obtained results. A step forward would be the standardization of the aforementioned method to assess the sludge filtration quality.

  12. Evaluation the frequency of factor V Leiden mutation in pregnant women with preeclampsia syndrome in an Iranian population

    Directory of Open Access Journals (Sweden)

    Azadeh Azinfar

    2012-01-01

    Full Text Available Background: Role of genetic factors in etiology of preeclampsia is not confirmed yet.Objective: Gene defect frequency varies in different geographic areas as well as ethnic groups. In this study, the role of factor V Leiden mutation in the pathogenesis of preeclampsia syndrome among the pregnant population of northern shore of Persian Gulf in Iran, were considered.Materials and Methods: Between Jan. 2008 and Dec. 2009, in a nested case control study, pregnant women with preeclampsia (N=198 as cases and healthy (N=201 as controls were enrolled in the study. DNA were extracted from 10 CC peripheral blood and analyzed for presence of factor V Leiden mutation in these subjects. The maternal and neonatal outcomes of pregnancy according to the distribution of factor V Leiden were also compared among cases.Results: In total, 17(8.6% of cases and 2(1% of controls showed the factor V Leiden mutation. The incidence of factor V Leiden was typically higher in preeclamptic women than control group (OR: 9.34 %95 CI: 2.12-41.01. There was no difference in incidence rate of preterm delivery< 37 weeks (OR: 1.23 %95 CI: 0.38-4.02, very early preterm delivery<32 weeks (OR: 1.00 %95 CI: 0.12-8.46, intra uterine fetal growth restriction (IUGR (OR: 1.32 %95 CI: 0.15-11.30 ,and the rate of cesarean section (OR: 0.88 %95 CI: 0.29-2.62 among cases based on the prevalence of factor V Leiden mutation.Conclusion: The pregnant women with factor V Leiden mutation are prone for preeclampsia syndrome during pregnancy, but this risk factor was not correlated to pregnancy complications in the studied women

  13. Storm Surge Modeling of Typhoon Haiyan at the Naval Oceanographic Office Using Delft3D

    Science.gov (United States)

    Gilligan, M. J.; Lovering, J. L.

    2016-02-01

    The Naval Oceanographic Office provides estimates of the rise in sea level along the coast due to storm surge associated with tropical cyclones, typhoons, and hurricanes. Storm surge modeling and prediction helps the US Navy by providing a threat assessment tool to help protect Navy assets and provide support for humanitarian assistance/disaster relief efforts. Recent advancements in our modeling capabilities include the use of the Delft3D modeling suite as part of a Naval Research Laboratory (NRL) developed Coastal Surge Inundation Prediction System (CSIPS). Model simulations were performed on Typhoon Haiyan, which made landfall in the Philippines in November 2013. Comparisons of model simulations using forecast and hindcast track data highlight the importance of accurate storm track information for storm surge predictions. Model runs using the forecast track prediction and hindcast track information give maximum storm surge elevations of 4 meters and 6.1 meters, respectively. Model results for the hindcast simulation were compared with data published by the JSCE-PICE Joint survey for locations in San Pedro Bay (SPB) and on the Eastern Samar Peninsula (ESP). In SPB, where wind-induced set-up predominates, the model run using the forecast track predicted surge within 2 meters in 38% of survey locations and within 3 meters in 59% of the locations. When the hindcast track was used, the model predicted within 2 meters in 77% of the locations and within 3 meters in 95% of the locations. The model was unable to predict the high surge reported along the ESP produced by infragravity wave-induced set-up, which is not simulated in the model. Additional modeling capabilities incorporating infragravity waves are required to predict storm surge accurately along open coasts with steep bathymetric slopes, such as those seen in island arcs.

  14. Jewish Medical Students and Graduates at the Universities of Padua and Leiden: 1617–1740

    Directory of Open Access Journals (Sweden)

    Kenneth Collins

    2013-01-01

    Full Text Available The first Jewish medical graduates at the University of Padua qualified in the fifteenth century. Indeed, Padua was the only medical school in Europe for most of the medieval period where Jewish students could study freely. Though Jewish students came to Padua from many parts of Europe the main geographical sources of its Jewish students were the Venetian lands. However, the virtual Padua monopoly on Jewish medical education came to an end during the seventeenth century as the reputation of the Dutch medical school in Leiden grew. For aspiring medieval Jewish physicians Padua was, for around three hundred years, the first, simplest, and usually the only choice.

  15. Die Leiden des jungen Werthers à luz da história do conceito de subjetividade

    OpenAIRE

    Silva, Felipe Vale da

    2013-01-01

    O artigo analisa os paralelos entre o retrato do 'sujeito moderno em crise' visto no romance Die Leiden des jungen Werthers de Goethe e, por outro lado, o perfil psicossocial do 'homem do sentimento' do século XVIII, fruto da cultura da Empfindsamkeit. Defendo a perspectiva de que, no romance, Goethe não apenas se utiliza do formato literário mais tradicional da Empfindsamkeit (o do romance epistolar), como também se apropria de topói e técnicas discursivas que lhe são próprias em registro ra...

  16. HELLP Syndrome and Cerebral Venous Sinus Thrombosis Associated with Factor V Leiden Mutation during Pregnancy

    Directory of Open Access Journals (Sweden)

    Zeynep Ozcan Dag

    2014-01-01

    Full Text Available Preeclampsia is a leading cause of maternal mortality and morbidity worldwide. The neurological complications of preeclampsia and eclampsia are responsible for a major proportion of the morbidity and mortality for women and their infants alike. Hormonal changes during pregnancy and the puerperium carry an increased risk of venous thromboembolism including cerebral venous sinus thrombosis (CVST. Factor 5 leiden (FVL is a procoagulant mutation associated primarily with venous thrombosis and pregnancy complications. We report a patient with FVL mutation who presented with CVST at 24th week of pregnancy and was diagnosed as HELLP syndrome at 34th week of pregnancy.

  17. Plasma lipoproteins in familial dysbetalipoproteinemia associated with apolipoproteins E2 (Arg158 -->Cys), E3-Leiden, and E2 (Lys146-->Gln), and effects of treatment with simvastatin

    NARCIS (Netherlands)

    Zhao, S.P.; Smelt, A.H.; Maagdenberg, A.M. van den; Tol, A. van; Vroom T.F.; Gevers Leuven, J.A.; Frants, R.R.; Havekes, L.M.; Laarse, A. van der; Hooft, F.M. van 't

    1994-01-01

    Using a density-gradient ultracentrifugation technique, we analyzed in detail the plasma lipoprotein profiles of 18 patients with familial dysbetalipoproteinemia (FD) who had apolipoprotein (apo) E2(Arg158-->Cys) homozygosity (the E2-158 variant, n = 6), apoE3-Leiden heterozygosity (the E3-Leiden

  18. In the absence of endogenous mouse apolipoprotein E, apolipoprotein E*2(Arg-158 → Cys) transgenic mice develop more severe hyperlipoproteinemia than apolipoprotein E*3-Leiden transgenic mice

    NARCIS (Netherlands)

    Vlijmen, B.J.M. van; Dijk, K.W. van; Hof, H.B. van 't; Gorp, P.J.J. van; Zee, A. van der; Boom, H. van der; Breuer, M.L.; Hofker, M.H.; Havekesf, L.M.

    1996-01-01

    Apolipoprotein E*2(Arg-155 → Cys) (APOE*2) transgenic mice were generated and compared to the previously generated apolipoprotein E*3- Leiden (APOE*3-Leiden) transgenic mice to study the variable expression of hyperlipoproteinemia associated with these two APOE variants. In the presence of the

  19. Reversal of hypercholesterolemia in apolipoprotein E2 and apolipoprotein E3-Leiden transgenic mice by adenovirus-mediated gene transfer of the VLDL receptor

    NARCIS (Netherlands)

    Dijk, K.W. van; Vlijmen, B.J.M. van; Zee, A. van der; Hof, B. van 't; Boom, H. van der; Kobayashi, K.; Chan, L.; Havekes, L.M.; Hofker, M.H.

    1998-01-01

    We have investigated the interaction of apolipoprotein E2(Arg158- Cys) (apoE2) and apolipoprotein E3Leiden (apoE3-Leiden) with the very low density lipoprotein (VLDL) receptor in vivo and in vitro to define the possible role of this receptor in lipoprotein metabolism and atherosclerosis. The in vivo

  20. Growth in The Hague versus decline in Leiden. A comparison of spatial development in two Dutch cities between 1700 and 1870

    Directory of Open Access Journals (Sweden)

    Jelmer van der Zweep

    2017-04-01

    1830–1870 The Hague underwent considerable densification inside the canal ring as well as extensions north and south of the city. The number of new tenements built on inner yards in The Hague can give a distorted impression, as can the number of demolished buildings in Leiden, because the 1870 maps were much more detailed. In Leiden the advent of new factories prompted new construction on the former city walls. The Hague, too, became a major industrial player, while continuing to profit from its function as the centre of government. In 1870, The Hague had almost twoand-a-half times as many inhabitants as Leiden (92,000 versus 39,000, but within the canal girdle Leiden was still more densely built up. Between 1700 and 1870, The Hague developed into one of the Netherlands’ biggest cities, which it still is. Leiden plummeted from second place to the middle bracket, where it continues to sit today.

  1. Effects of dietary fish oil on serum lipids and VLDL kinetics in hyperlipidemic apolipoprotein E*3-Leiden transgenic mice

    NARCIS (Netherlands)

    Vlijmen, B.J.M. van; Mensink, R.P.; Hof, H.B. van 't; Offermans, R.F.G.; Hofker, M.H.; Havekes, L.M.

    1998-01-01

    Studying the effects of dietary fish oil on VLDL metabolism in humans is subject to both large intra- and interindividual variability. In the present study we therefore used hyperlipidentic apolipoprotein (APO) E*3-Leiden mice, which have impaired chylomicron and very low density lipoprotein (VDL)

  2. Factor V G1691A (Leiden is a major etiological factor in Egyptian Budd-Chiari syndrome patients

    Directory of Open Access Journals (Sweden)

    Tawhida Y. Abdel Ghaffar

    2011-12-01

    Full Text Available Objective: Budd-Chiari syndrome is a multifactorial disease in which several prothrombotic disorders may predispose patients to the development of thrombosis at this uncommon location (hepatic veins. The aim of this study was to determine the prevalence and characteristics of inherited thrombophilia in Egyptian Budd-Chiari syndrome patients.Materials and Methods: The study included 47 Budd-Chiari syndrome patients (20 children and 27 adults. Genotyping of Factor V G1691A (Leiden, prothrombin G20210A (PT, and methylenetetrahydrofolate reductase C677T were performed using real-time PCR and fluorescence melting curve detection analysis.Results: Factor V Leiden was observed in 29 patients (61.7%. It is the only factor that caused Budd-Chiari syndrome in 18 of the patients and in 5 of the patients with inferior vena cava involvement. Myeloproliferative disease was noted in 12 (25.5% patients, antiphospholipid syndrome in 5 (10.6%, and Behcet’s disease in 3 (6.4%. Interestingly, 3 of the children with Budd-Chiari syndrome had lipid storage disease.Conclusion: Factor V Leiden was a major etiological factor in Egyptian Budd-Chiari syndrome patients, which may have been related to the high frequency of this mutation in the study region. Factor V Leiden was also a strong thrombophilic factor and the leading cause of inferior vena cava thrombosis in these patients. Lipid storage disease should be included as a risk factor for Budd-Chiari syndrome.

  3. Risk of venous thromboembolism and myocardial infarction associated with factor V Leiden and prothrombin mutations and blood type

    DEFF Research Database (Denmark)

    Sode, Birgitte F; Allin, Kristine H; Dahl, Morten

    2013-01-01

    ABO blood type locus has been reported to be an important genetic determinant of venous and arterial thrombosis in genome-wide association studies. We tested the hypothesis that ABO blood type alone and in combination with mutations in factor V Leiden R506Q and prothrombin G20210A is associated...

  4. Has one of Captain Cook’s possums landed in Leiden? The possible holotype of Pseudocheirus peregrinus (Boddaert, 1785)

    NARCIS (Netherlands)

    Smeenk, C.

    2009-01-01

    The identity of an old female specimen of Pseudocheirus peregrinus (Boddaert, 1785) in the National Museum of Natural History, Leiden, is discussed and the early descriptions and nomenclatural history of the species are reviewed. The assumption by Temminck (1824) and Jentink (1888) that the animal

  5. Charles Darwin’s lost Cinereous Harrier found in the collection of the National Museum of Natural History Leiden

    NARCIS (Netherlands)

    Grouw, van H.; Steinheimer, F.D.

    2008-01-01

    During reorganisation of the Leiden bird collection a mounted harrier was found what seemed to be one of the still lost specimens collected by Darwin. After closer research it turned out it was indeed the last missing harrier of the Darwin collection.

  6. Cholesteryl ester transfer protein decreases high-density lipoprotein and severely aggravates atherosclerosis in APOE*3-Leiden mice

    NARCIS (Netherlands)

    Westerterp, M.; Hoogt, C.C. van der; Haan, W. de; Offerman, E.H.; Dallinga-Thie, G.M.; Jukema, J.W.; Havekes, L.M.; Rensen, P.C.N.

    2006-01-01

    OBJECTIVE - The role of cholesteryl ester transfer protein (CETP) in the development of atherosclerosis is still undergoing debate. Therefore, we evaluated the effect of human CETP expression on atherosclerosis in APOE*3-Leiden (E3L) mice with a humanized lipoprotein profile. METHODS AND RESULTS -

  7. The original Pathologische Anatomie Leiden-Endothelium monoclonal antibody recognizes a vascular endothelial growth factor binding site within neuropilin-1

    NARCIS (Netherlands)

    Jaalouk, Diana E.; Ozawa, Nfichael G.; Sun, Jessica; Lahdenranta, Johanna; Schlingemann, Reinier O.; Pasqualini, Renata; Arap, Wadih

    2007-01-01

    For two decades, the antigen recognized by the Pathologische Anatomie Leiden-Endothelium (PAL-E) monoclonal antibody, a standard vascular endothelial cell marker, has remained elusive. Here, we used a combinatorial phage display-based approach ("epitope mapping") to select peptides binding to the

  8. Relative validity of the food frequency questionnaire used to assess dietary intake in the Leiden Longevity Study

    NARCIS (Netherlands)

    Streppel, M.T.; Vries, de J.H.M.; Meyboom, S.; Beekman, M.; Craen, A.J.M.; Slagboom, P.E.; Feskens, E.J.M.

    2013-01-01

    Background - Invalid information on dietary intake may lead to false diet-disease associations. This study was conducted to examine the relative validity of the food frequency questionnaire (FFQ) used to assess dietary intake in the Leiden Longevity Study. Methods - A total of 128 men and women

  9. Impact of the factor V Leiden mutation on the outcome of pneumococcal pneumonia: a controlled laboratory study

    NARCIS (Netherlands)

    Schouten, Marcel; van 't Veer, Cornelis; Roelofs, Joris Jth; Levi, Marcel; van der Poll, Tom

    2010-01-01

    Introduction: Streptococcus (S.) pneumoniae is the most common cause of community-acquired pneumonia. The factor V Leiden (FVL) mutation results in resistance of activated FV to inactivation by activated protein C and thereby in a prothrombotic phenotype. Human heterozygous FVL carriers have been

  10. Meta-analysis of factor V Leiden and ischemic stroke in young adults: the importance of case ascertainment.

    Science.gov (United States)

    Hamedani, Ali G; Cole, John W; Mitchell, Braxton D; Kittner, Steven J

    2010-08-01

    The factor V Leiden mutation is associated with ischemic stroke in children but not in adults. Whether it is associated with ischemic stroke in young adults, however, is uncertain. To address this issue, we performed a meta-analysis of 18 case-control studies of ischemic stroke in adults 50 years of age and younger published before June 2009. Across all studies, factor V Leiden was detected in 154 of 2045 cases (7.5%) and 217 of 5307 controls (4.1%), yielding a fixed-effect odds ratio of 2.00 (95% CI, 1.59-2.51). However, further analyses revealed substantial heterogeneity among these studies (P=0.005 for Q-test of heterogeneity). Hypothesizing that this heterogeneity could be related to differences among studies in case selection criteria, we stratified the meta-analysis into studies for which case samples were enriched or not enriched to include cases having an increased likelihood of prothrombotic genetic involvement ("selected" ischemic stroke studies, n=9) and those that recruited cases from consecutive neurology referrals or hospitalizations ("unselected" ischemic stroke studies, n=8). Among the 9 "selected" ischemic stroke studies, factor V Leiden was more strongly associated with stroke (OR, 2.73; 95% CI, 1.98-3.75), whereas among the 8 "unselected" ischemic stroke studies, the association between factor V Leiden and stroke was substantially weaker (OR, 1.40; 95% CI, 0.998-1.95). This difference was found to be statistically significant (P=0.003 for Woolf test for heterogeneity). We conclude that factor V Leiden is associated with ischemic stroke in young adults, particularly in patient populations in which there is an increased clinical suspicion of prothrombotic state.

  11. What We Have Learned from San Francisco Declaration on Research Assessment and Leiden Manifesto?

    Directory of Open Access Journals (Sweden)

    Carey Ming-Li Chen

    2017-03-01

    Full Text Available In recent years, the research performance evaluation of members of the academic community conducted by government or institutions has been applied with multiple indicators and peer review, however, there are many controversies about the design and application of research evaluation indicators. This article aims to introduce the development process of San Francisco Declaration on Research Assessment (DORA and Leiden Manifesto and summarize their contents of guidelines and attempts to compare the differences between these two documents. It hopes that this article can arise the attention and reflection of research evaluation indicators and relevant issues from Taiwan academic community to reach consensus of utilization of research evaluation indicators. It will be beneficial to develop the version of declaration with local characteristics in the future.

  12. Die Leiden des jungen Werthers à luz da história do conceito de subjetividade

    Directory of Open Access Journals (Sweden)

    Felipe Vale da Silva

    2013-06-01

    Full Text Available O artigo analisa os paralelos entre o retrato do 'sujeito moderno em crise' visto no romance Die Leiden des jungen Werthers de Goethe e, por outro lado, o perfil psicossocial do 'homem do sentimento' do século XVIII, fruto da cultura da Empfindsamkeit. Defendo a perspectiva de que, no romance, Goethe não apenas se utiliza do formato literário mais tradicional da Empfindsamkeit (o do romance epistolar, como também se apropria de topói e técnicas discursivas que lhe são próprias em registro radicalmente heterodoxo. A argumentação nos ligará a uma dedução da visão do conceito de subjetividade moderna com que Goethe trabalha em sua fase final do Sturm und Drang, e que o situa como importante nome do discurso filosófico da modernidade.

  13. Sensitized mutagenesis screen in Factor V Leiden mice identifies thrombosis suppressor loci.

    Science.gov (United States)

    Westrick, Randal J; Tomberg, Kärt; Siebert, Amy E; Zhu, Guojing; Winn, Mary E; Dobies, Sarah L; Manning, Sara L; Brake, Marisa A; Cleuren, Audrey C; Hobbs, Linzi M; Mishack, Lena M; Johnston, Alexander J; Kotnik, Emilee; Siemieniak, David R; Xu, Jishu; Li, Jun Z; Saunders, Thomas L; Ginsburg, David

    2017-09-05

    Factor V Leiden ( F5 L ) is a common genetic risk factor for venous thromboembolism in humans. We conducted a sensitized N -ethyl- N -nitrosourea (ENU) mutagenesis screen for dominant thrombosuppressor genes based on perinatal lethal thrombosis in mice homozygous for F5 L ( F5 L/L ) and haploinsufficient for tissue factor pathway inhibitor ( Tfpi +/- ). F8 deficiency enhanced the survival of F5 L/L Tfpi +/- mice, demonstrating that F5 L/L Tfpi +/- lethality is genetically suppressible. ENU-mutagenized F5 L/L males and F5 L/+ Tfpi +/- females were crossed to generate 6,729 progeny, with 98 F5 L/L Tfpi +/- offspring surviving until weaning. Sixteen lines, referred to as "modifier of Factor 5 Leiden ( MF5L1-16 )," exhibited transmission of a putative thrombosuppressor to subsequent generations. Linkage analysis in MF5L6 identified a chromosome 3 locus containing the tissue factor gene ( F3 ). Although no ENU-induced F3 mutation was identified, haploinsufficiency for F3 ( F3 +/- ) suppressed F5 L/L Tfpi +/- lethality. Whole-exome sequencing in MF5L12 identified an Actr2 gene point mutation (p.R258G) as the sole candidate. Inheritance of this variant is associated with suppression of F5 L/L Tfpi +/- lethality ( P = 1.7 × 10 -6 ), suggesting that Actr2 p.R258G is thrombosuppressive. CRISPR/Cas9 experiments to generate an independent Actr2 knockin/knockout demonstrated that Actr2 haploinsufficiency is lethal, supporting a hypomorphic or gain-of-function mechanism of action for Actr2 p.R258G Our findings identify F8 and the Tfpi/F3 axis as key regulators in determining thrombosis balance in the setting of F5 L and also suggest a role for Actr2 in this process.

  14. Computational Modeling on Concrete, Masonry and Fiber-reinforced Composites : Proceedings of the Workshop on 17 – 18 June 2009, Delft, The Netherlands

    NARCIS (Netherlands)

    Hendriks, M.A.N.; Billington, S.L.

    2009-01-01

    This booklet comprises the extended abstracts to be presented at the Ma(gni)FiCo workshop held in Delft, The Netherlands, on 17-18 June 2009. The spirit of this workshop is to have a small gathering with ample time for lively conversation and interaction among the student and faculty researchers. As

  15. Advances in computer-aided engineering : CAD/CAM-research at Delft University of Technology. Report of the VF-project CAD/CAM 1989-1994

    NARCIS (Netherlands)

    Undetermined, U.

    1994-01-01

    This book contains a collection of articles describing on-going CAD/CAM-research at several engineering faculties at Delft University of Technology. Two main themes covered in this book are 'Conceptual design of complex products' and 'Product modelling and product data exchange'.

  16. Institute of place making : A project by the chair of Landscape Architecture at the TU Delft. Oerol 2013: Sense of place

    NARCIS (Netherlands)

    Pouderoijen, M.T.; Piccinini, D.

    2013-01-01

    This booklet shows the results of a project developed by TU Delft in a Master elective course offered by the chair of Landscape Architecture: Landscape Architecture ON site, being part of Oerol Festival 2013. The aim of the project was to express the landscape of Terschelling into a temporarily

  17. Key Inflammatory Processes in Human NASH Are Reflected in Ldlr-/-.Leiden Mice: A Translational Gene Profiling Study.

    Science.gov (United States)

    Morrison, Martine C; Kleemann, Robert; van Koppen, Arianne; Hanemaaijer, Roeland; Verschuren, Lars

    2018-01-01

    Introduction: It is generally accepted that metabolic inflammation in the liver is an important driver of disease progression in NASH and associated matrix remodeling/fibrosis. However, the exact molecular inflammatory mechanisms are poorly defined in human studies. Investigation of key pathogenic mechanisms requires the use of pre-clinical models, for instance for time-resolved studies. Such models must reflect molecular disease processes of importance in patients. Herein we characterized inflammation in NASH patients on the molecular level by transcriptomics and investigated whether key human disease pathways can be recapitulated experimentally in Ldlr -/- .Leiden mice, an established pre-clinical model of NASH. Methods: Human molecular inflammatory processes were defined using a publicly available NASH gene expression profiling dataset (GSE48452) allowing the comparison of biopsy-confirmed NASH patients with normal controls. Gene profiling data from high-fat diet (HFD)-fed Ldlr -/- .Leiden mice (GSE109345) were used for assessment of the translational value of these mice. Results: In human NASH livers, we observed regulation of 65 canonical pathways of which the majority was involved in inflammation (32%), lipid metabolism (16%), and extracellular matrix/remodeling (12%). A similar distribution of pathways across these categories, inflammation (36%), lipid metabolism (24%) and extracellular matrix/remodeling (8%) was observed in HFD-fed Ldlr -/- .Leiden mice. Detailed evaluation of these pathways revealed that a substantial proportion (11 out of 13) of human NASH inflammatory pathways was recapitulated in Ldlr -/- .Leiden mice. Furthermore, the activation state of identified master regulators of inflammation (i.e., specific transcription factors, cytokines, and growth factors) in human NASH was largely reflected in Ldlr -/- .Leiden mice, further substantiating its translational value. Conclusion: Human NASH is characterized by upregulation of specific

  18. Key Inflammatory Processes in Human NASH Are Reflected in Ldlr−/−.Leiden Mice: A Translational Gene Profiling Study

    Science.gov (United States)

    Morrison, Martine C.; Kleemann, Robert; van Koppen, Arianne; Hanemaaijer, Roeland; Verschuren, Lars

    2018-01-01

    Introduction: It is generally accepted that metabolic inflammation in the liver is an important driver of disease progression in NASH and associated matrix remodeling/fibrosis. However, the exact molecular inflammatory mechanisms are poorly defined in human studies. Investigation of key pathogenic mechanisms requires the use of pre-clinical models, for instance for time-resolved studies. Such models must reflect molecular disease processes of importance in patients. Herein we characterized inflammation in NASH patients on the molecular level by transcriptomics and investigated whether key human disease pathways can be recapitulated experimentally in Ldlr−/−.Leiden mice, an established pre-clinical model of NASH. Methods: Human molecular inflammatory processes were defined using a publicly available NASH gene expression profiling dataset (GSE48452) allowing the comparison of biopsy-confirmed NASH patients with normal controls. Gene profiling data from high-fat diet (HFD)-fed Ldlr−/−.Leiden mice (GSE109345) were used for assessment of the translational value of these mice. Results: In human NASH livers, we observed regulation of 65 canonical pathways of which the majority was involved in inflammation (32%), lipid metabolism (16%), and extracellular matrix/remodeling (12%). A similar distribution of pathways across these categories, inflammation (36%), lipid metabolism (24%) and extracellular matrix/remodeling (8%) was observed in HFD-fed Ldlr−/−.Leiden mice. Detailed evaluation of these pathways revealed that a substantial proportion (11 out of 13) of human NASH inflammatory pathways was recapitulated in Ldlr−/−.Leiden mice. Furthermore, the activation state of identified master regulators of inflammation (i.e., specific transcription factors, cytokines, and growth factors) in human NASH was largely reflected in Ldlr−/−.Leiden mice, further substantiating its translational value. Conclusion: Human NASH is characterized by upregulation of specific

  19. Republic of Letters, Academies and Scientific Societies in the 18th Century: Leiden jar and science in teaching

    Directory of Open Access Journals (Sweden)

    Wagner Tadeu Jardim

    2017-12-01

    Full Text Available In this paper, the panorama that underpins the construction of the first electric condenser, known as the Leiden Jar, will be presented. Besides, the themes about the construction of science which are relevant to be discussed in Physics classes that concerns the development of this apparatus will be pointed. For this purpose, a historical narrative was constructed from primary and secondary sources, and it was inspired by the historiographical strand called Cultural History of Science. Thus, we seek to emphasize how ways of spreading knowledge in the context of Scientific Academies, Scientific Societies and what has been called Republic of Letters in the eighteenth century, constitute substantial extra-laboratory scientific practices for an understanding of the development of the Leiden Jar. Finally, in accordance with results from researches in the area of Science Teaching, we present some thoughts upon which elements of this narrative could be taken to the classroom.

  20. Plasma and liver lipidomics response to an intervention of rimonabant in ApoE*3Leiden.CETP transgenic mice.

    Directory of Open Access Journals (Sweden)

    Chunxiu Hu

    Full Text Available Lipids are known to play crucial roles in the development of life-style related risk factors such as obesity, dyslipoproteinemia, hypertension and diabetes. The first selective cannabinoid-1 receptor blocker rimonabant, an anorectic anti-obesity drug, was frequently used in conjunction with diet and exercise for patients with a body mass index greater than 30 kg/m(2 with associated risk factors such as type II diabetes and dyslipidaemia in the past. Less is known about the impact of this drug on the regulation of lipid metabolism in plasma and liver in the early stage of obesity.We designed a four-week parallel controlled intervention on apolipoprotein E3 Leiden cholesteryl ester transfer protein (ApoE*3Leiden.CETP transgenic mice with mild overweight and hypercholesterolemia. A liquid chromatography-linear ion trap-Fourier transform ion cyclotron resonance-mass spectrometric approach was employed to investigate plasma and liver lipid responses to the rimonabant intervention. Rimonabant was found to induce a significant body weight loss (9.4%, p<0.05 and a significant plasma total cholesterol reduction (24%, p<0.05. Six plasma and three liver lipids in ApoE*3Leiden.CETP transgenic mice were detected to most significantly respond to rimonabant treatment. Distinct lipid patterns between the mice were observed for both plasma and liver samples in rimonabant treatment vs. non-treated controls. This study successfully applied, for the first time, systems biology based lipidomics approaches to evaluate treatment effects of rimonabant in the early stage of obesity.The effects of rimonabant on lipid metabolism and body weight reduction in the early stage obesity were shown to be moderate in ApoE*3Leiden.CETP mice on high-fat diet.

  1. The Prebiotic Inulin Aggravates Accelerated Atherosclerosis in Hypercholesterolemic APOE*3-Leiden Mice.

    Science.gov (United States)

    Hoving, Lisa R; de Vries, Margreet R; de Jong, Rob C M; Katiraei, Saeed; Pronk, Amanda; Quax, Paul H A; van Harmelen, Vanessa; Willems van Dijk, Ko

    2018-02-03

    The prebiotic inulin has proven effective at lowering inflammation and plasma lipid levels. As atherosclerosis is provoked by both inflammation and hyperlipidemia, we aimed to determine the effect of inulin supplementation on atherosclerosis development in hypercholesterolemic APOE*3-Leiden ( E3L ) mice. Male E3L mice were fed a high-cholesterol (1%) diet, supplemented with or without 10% inulin for 5 weeks. At week 3, a non-constrictive cuff was placed around the right femoral artery to induce accelerated atherosclerosis. At week 5, vascular pathology was determined by lesion thickness, vascular remodeling, and lesion composition. Throughout the study, plasma lipids were measured and in week 5, blood monocyte subtypes were determined using flow cytometry analysis. In contrast to our hypothesis, inulin exacerbated atherosclerosis development, characterized by increased lesion formation and outward vascular remodeling. The lesions showed increased number of macrophages, smooth muscle cells, and collagen content. No effects on blood monocyte composition were found. Inulin significantly increased plasma total cholesterol levels and total cholesterol exposure. In conclusion, inulin aggravated accelerated atherosclerosis development in hypercholesterolemic E3L mice, accompanied by adverse lesion composition and outward remodeling. This process was not accompanied by differences in blood monocyte composition, suggesting that the aggravated atherosclerosis development was driven by increased plasma cholesterol.

  2. The Prebiotic Inulin Aggravates Accelerated Atherosclerosis in Hypercholesterolemic APOE*3-Leiden Mice

    Directory of Open Access Journals (Sweden)

    Lisa R. Hoving

    2018-02-01

    Full Text Available The prebiotic inulin has proven effective at lowering inflammation and plasma lipid levels. As atherosclerosis is provoked by both inflammation and hyperlipidemia, we aimed to determine the effect of inulin supplementation on atherosclerosis development in hypercholesterolemic APOE*3-Leiden (E3L mice. Male E3L mice were fed a high-cholesterol (1% diet, supplemented with or without 10% inulin for 5 weeks. At week 3, a non-constrictive cuff was placed around the right femoral artery to induce accelerated atherosclerosis. At week 5, vascular pathology was determined by lesion thickness, vascular remodeling, and lesion composition. Throughout the study, plasma lipids were measured and in week 5, blood monocyte subtypes were determined using flow cytometry analysis. In contrast to our hypothesis, inulin exacerbated atherosclerosis development, characterized by increased lesion formation and outward vascular remodeling. The lesions showed increased number of macrophages, smooth muscle cells, and collagen content. No effects on blood monocyte composition were found. Inulin significantly increased plasma total cholesterol levels and total cholesterol exposure. In conclusion, inulin aggravated accelerated atherosclerosis development in hypercholesterolemic E3L mice, accompanied by adverse lesion composition and outward remodeling. This process was not accompanied by differences in blood monocyte composition, suggesting that the aggravated atherosclerosis development was driven by increased plasma cholesterol.

  3. Factor V Leiden does not have a role in cryptogenic ischemic stroke among Iranian young adults.

    Science.gov (United States)

    Kheradmand, Ehsan; Pourhossein, Meraj; Amini, Gilda; Saadatnia, Mohammad

    2014-01-01

    Different risk factors have been suggested for ischemic stroke in young adults. In a group of these patients despite of extensive diagnostic work-up, the primary cause remains unknown. Coagulation tendency is accounted as a possible cause in these patients. Previous studies on factor V Leiden (FVL) as the main cause of inherited thrombophilia for clarifying the role of FVL in stroke have resulted in controversial findings. The current study investigates the role of this factor in ischemic stroke among Iranians. This case-control study was performed between September 2007 and December 2008 in Isfahan, Iran. The case group comprised of 22 patients of which 15 were males and 7 were females with age range of ≤50 years, diagnosed as ischemic stroke without classic risk factors and the control group consisted of 54 healthy young adults. After filling consent form, venous blood samples were obtained and sent to the laboratory for genetic examination. No FVL mutation was found in the case group. There was one carrier of the mutation as heterozygous in the control group (relative frequency = 1.85%). Based on our study, FVL might not be considered as an independent risk factor for ischemic stroke in Iranian individuals who are not suffering from other risk factors of ischemic stroke.

  4. Factor V leiden and ischemic stroke risk: the Genetics of Early Onset Stroke (GEOS) study.

    Science.gov (United States)

    Hamedani, Ali G; Cole, John W; Cheng, Yuching; Sparks, Mary J; O'Connell, Jeffrey R; Stine, Oscar C; Wozniak, Marcella A; Stern, Barney J; Mitchell, Braxton D; Kittner, Steven J

    2013-05-01

    Factor V Leiden (FVL) has been associated with ischemic stroke in children but not in adults. Although the FVL mutation is associated with increased risk for venous thrombosis, its association with ischemic stroke in young adults remains uncertain. Therefore, we examined the association between FVL and ischemic stroke in participants of the Genetics of Early Onset Stroke (GEOS) study. A population-based case control study identified 354 women and 476 men 15 to 49 years of age with first-ever ischemic stroke and 907 controls. Participant-specific data included vascular risk factors, FVL genotype and, for cases, the ischemic stroke subtype by modified Trial of ORG 10172 in Acute Stroke criteria. Logistic regression was used to calculate odds ratios for the entire population and for subgroups stratified by risk factors and ischemic stroke subtype. The frequency of the FVL mutation was similar between ischemic stroke patients (3.6%; 95% confidence interval [CI] 2.5%-5.1%) and nonstroke controls (3.8%; 95% CI 2.7%-5.2%). This frequency did not change significantly when cases were restricted to patients with stroke of undetermined etiology (4.1%; 95% CI 2.6%-6.4%). Among young adults, we found no evidence for an association between FVL and either all ischemic stroke or the subgroup with stroke of undetermined etiology. Published by Elsevier Inc.

  5. Familial longevity is marked by better cognitive performance at middle age: the Leiden Longevity Study.

    Directory of Open Access Journals (Sweden)

    Marjon Stijntjes

    Full Text Available BACKGROUND: Decline in cognitive performance is a highly prevalent health condition in elderly. We studied whether offspring of nonagenarian siblings with a familial history of longevity, perform better on cognitive tests compared to their partners as controls. This is relevant since it could provide insights into determinants underlying decline in cognitive performance. METHODS: Cross-sectional analysis within the longitudinal cohort of the Leiden Longevity Study consisting of middle-aged offspring of nonagenarian siblings together with their partners (n = 500, mean age (SD 66.3 (6.1 and 65.7 (7.2 years, respectively as controls. Memory function, attention and processing speed were tested using the 15-Picture Learning Test, Stroop test and Digit Symbol Substitution Test. Data were analyzed with regression adjusted for age, gender, years of education and additionally for diabetes mellitus, cardiovascular diseases, alcohol use, smoking, inflammatory markers and apolipoprotein E genotype. Robust standard errors were used to account for familial relationships among the offspring. RESULTS: Cognitive performance was worse at higher calendar age (p<0.001, all except Stroop test part 1. The offspring performed better compared to their partners on trial 3 (p = 0.005, the immediate (p = 0.016 and delayed (p = 0.004 recall of the 15-Picture Learning Test as well as on the interference and combined interference score of the Stroop test (p = 0.014 and p = 0.036, respectively in the fully adjusted model. The difference between offspring and partners was estimated to be more than three years according to the observed difference in calendar age. CONCLUSIONS: Offspring of nonagenarian siblings with a familial history of longevity have better cognitive performance compared to the group of their partners of comparable age. This effect is independent of age-related diseases and known possible confounders. Possible explanations might be differences in subclinical

  6. Thromboembolic events in Fabry disease and the impact of factor V Leiden.

    Science.gov (United States)

    Lenders, Malte; Karabul, Nesrin; Duning, Thomas; Schmitz, Boris; Schelleckes, Michael; Mesters, Rolf; Hense, Hans-Werner; Beck, Michael; Brand, Stefan-Martin; Brand, Eva

    2015-03-10

    Although several reports suggest an increased thromboembolic event rate, especially regarding strokes and TIAs at early age in patients with Fabry disease (FD), the risk for patients with FD to experience these events, the clinical relevance of additional risk factors including the concurrence of factor V Leiden (FVL), and the benefit of enzyme replacement therapy (ERT) regarding these events remain unclear. Three hundred four consecutively recruited patients with FD were evaluated for their lifetime occurrence of thromboembolic events such as stroke, TIA, deep vein thrombosis, and pulmonary embolism. The thromboembolic risk was determined in patients with FD and concurrent FVL, and the impact of ERT was assessed. The 304 patients with FD had a median age of 41 years and 53 (17.4%) had experienced at least one thromboembolic event during their lifetime. Among 226 patients with FD screened for FVL, 16 gene carriers were identified (7.1%). The occurrence of thromboembolic events in patients with FD and concurrent FVL was significantly increased compared to those without FVL (hazard ratio = 5.45, 95% confidence interval 2.29-12.99; p risk of thromboembolic events compared to those without ERT (hazard ratio = 0.362, 95% confidence interval 0.132-0.992; p = 0.0422). This observational study confirms that patients with FD have a high risk of clinically relevant thromboembolic events, which could be aggravated by a concurrence of FVL. ERT might be of benefit in preventing vascular events in patients with FD. The latter observation needs confirmation, however, by randomized and controlled clinical trials. © 2015 American Academy of Neurology.

  7. Phenotypic presentation of thrombophilia in double heterozygote for factor v leiden and prothrombin 20210 G>A mutations: Case report

    Directory of Open Access Journals (Sweden)

    Nagorni-Obradović Ljudmila

    2014-01-01

    Full Text Available Physicians usually do not suspect pulmonary thromboembolism in younger patients except in those who have thrombophilia. In those latter patients some special conditions such as trauma or surgery may provoke the disease. In some adult persons, thrombophilia may still remain unrecognized, until appearance of additional conditions influence development of thrombosis. A 55-year-old Caucasian female, non-smoker, experienced sudden chest pain and hemoptysis without chest trauma. History taking revealed type 2 diabetes mellitus and hypothyroidism. She was overweight with body mass index 29.0. The review of the family history revealed that her father and mother died of brain infarction, while her 22-year-old son and 24-year-old daughter were healthy. Due to suspicion for thrombosis, multi-slice computerized tomography thorax scan was done and pulmonary embolism was diagnosed. Although without clear risk factor for thrombosis in our patient, we performed laboratory investigation for congenital thrombophilia. Genetic analysis showed double heterozygous for factor V Leiden and prothrombin 20210 G>A mutations. Congenital thrombophilia was risk factor for thrombosis in our patient but haemostatic imbalance was not previously clinically recognized. She had two pregnancies without complications. Appearance of other associative factors such as endocrine disorders - hypothyroidism and metabolic syndrome with diabetes type 2, and overweigh were additional potential triggers for clinical manifestation of pulmonary thromboembolism in her adult age. Her children underwent genetic analysis, too. The son was also double heterozygous for factor V Leiden and prothrombin 20210 G>A mutations, while daughter was heterozygous for factor V Leiden, and none had clinical signs of thrombosis. [Projekat Ministarstva nauke Republike Srbije, br. ON175081 i br. ON 175091

  8. Contributions of radiochemistry and nuclear analytical techniques to society and technology: some examples of 35 years’ experience in Delft

    International Nuclear Information System (INIS)

    Bode, Peter

    2013-01-01

    Budget cuts and the oscillating public debates on the benefits of nuclear research reactor facilities are a continuous threat to many nuclear institutions. University affiliated institutions often face additional problems if their facilities offer sufficient scientific challenge and if an education in nuclear sciences provide students a sound outlook for a professional career. Such discussions may be an excuse for non-fulfilment of vacancies and reduced priority in the academic curriculum. Universities tend to reallocate their funds to more contemporary sciences such as molecular biology and nanotechnology. Their choices are based on relevance, quality viability and productivity. Relevance is often measured on the basis of external funding of research programs as well as on career opportunities for students. However, the areas with opportunities for external funding are largely determined by socio-economic developments, sometimes even at the (inter)national political level. The thematic areas in the scientific Framework Programs of the European Union illustrate this. The relevance and viability of an expensive facility like a nuclear reactor centre can also be demonstrated by making the facilities available to provide measurements on request by outsiders. Ideally, such services should be sustainable, but even the existence may lead to consider the centre being of regional or national importance. Nuclear reactor centres have various options for such services, like production of radionuclides; neutron transmutation doping; neutron activation analysis; neutron radiography and others. This contribution gives examples of the typical analytical services provided by the Interuniversity Reactor Institute of the Delft University of Technology. This institute houses the only university research reactor in the Netherlands, a 2 MW swimming pool reactor, with associated facilities for neutron research, neutron activation and radiochemistry. Within the services provided by the

  9. Coagulopathy triggered autoimmunity: experimental antiphospholipid syndrome in factor V Leiden mice

    Science.gov (United States)

    2013-01-01

    Background We investigated interactions between genetically and autoimmune-mediated coagulopathies by inducing experimental antiphospholipid syndrome (eAPS) in mice carrying the factor V Leiden (FVL) mutation. Methods eAPS was induced in heterozygous and homozygous FVL transgenic mice (C57BL/6 background) by immunization with β2-glycoprotein I (β2-GPI). Autoantibody levels were measured at 1 and 5 months post-immunization. Mice were tested at 4 months post-immunization for behavior and cognitive function in the staircase, elevated plus-maze, and swim T-maze tests. Brains were removed and analyzed by immunohistochemistry for inflammatory markers and neurodegenerative processes. Results A single immunization with β2-GPI induced significantly higher and longer-lasting immune responses, and this was dependent on the number of FVL alleles. At 1 and 5 months post-immunization, levels of antibodies rose from 1.17 ± 0.07 to 1.62 ± 0.17 (optical density units; ODU) in homozygous FVL mice, compared with stable levels of 0.59 ± 0.17 and 0.48 ± 0.16 ODU in heterozygous FVL mice and a drop from 1.62 ± 0.21 to 0.61 ± 0.13 ODU in wild-type mice. Behavioral and cognitive clinical features of eAPS were also correlated with FVL allele load, as assessed by the elevated plus-maze (altered anxiety), staircase (hyperactivity and higher exploration), and swim T-maze (impaired learning) tests. Histological studies identified significant neurodegenerative changes in both grey and white matter in the eAPS-FVL brains. In spite of the potential interaction of two prothrombotic disease states, there were no ischemic lesions seen in this group. Conclusions The results indicate that genetically mediated coagulopathies increase the risk of developing coagulation-targeted autoimmune responses, and suggest the importance of antibody-mediated neurodegenerative processes in the brain in APS. PMID:23566870

  10. List of the primary types of social wasps (Hymenoptera: Vespidae) deposited in the Nationaal Natuurhistorisch Museum, Leiden, and the Zoölogisch Museum, Amsterdam

    NARCIS (Netherlands)

    Kojima, J.; Achterberg, van C.

    1997-01-01

    The primary types of social wasp subfamilies Vespinae, Polistinae and Stenogastrinae housed in the Nationaal Natuurhistorisch Museum in Leiden and the Zoölogisch Museum in Amsterdam are listed. Their complete label data are given unless they are available elsewhere. Lectotypes of Polistes snelleni

  11. China Back in the Frame. A comparative study of Canton, Whampoa and Macao harbour views in the Leiden Museum of Ethnology and in the Guangzhou Museum

    NARCIS (Netherlands)

    Poel, van der R.H.M.; Groenendijk, E.; Viallé, C.; Blussé, L.

    2009-01-01

    This article presents a brief overview of research results deriving from the investigation of a group of 18th and 19th century export oil paintings from China in the collection of the National Museum of Ethnology n Leiden. The oils were compared with a group of reverse glass paintings in the same

  12. Prothrombin 20210 G: a mutation and Factor V Leiden mutation in women with a history of severe preeclampsia and (H)ELLP syndrome

    NARCIS (Netherlands)

    van Pampus, M. G.; Wolf, H.; Koopman, M. M.; van den Ende, A.; Buller, H. R.; Reitsma, P. H.

    2001-01-01

    The 20210 G-A prothrombin gene variant and the Factor V Leiden mutation are mutations associated with venous thrombotic risk. The aim of our study was to assess the prevalence of these specific mutations in women with a history of preeclampsia or hemolysis elevated liver enzymes, and low platelet

  13. The Leiden/Argentine/Bonn (LAB) Survey of Galactic HI : Final data release of the combined LDS and IAR surveys with improved stray-radiation corrections

    NARCIS (Netherlands)

    Kaberla, P.M.W.; Burton, W.B.; Hartmann, L.; Arnal, E.M.; Bajaja, E.; Morras, R.; Pöppel, W.G.L.

    2005-01-01

    We present the final data release of observations of ?21-cm emission from Galactic neutral hydrogen over the entire sky, merging the Leiden/Dwingeloo Survey (LDS: Hartmann & Burton 1997, Atlas of Galactic Neutral Hydrogen) of the sky north of ? = ?30? with the Instituto Argentino de Radioastronomía

  14. Enhancement by factor V Leiden mutation of risk of deep-vein thrombosis associated with oral contraceptives containing a third-generation progestagen

    NARCIS (Netherlands)

    Bloemenkamp, K. W.; Rosendaal, F. R.; Helmerhorst, F. M.; Büller, H. R.; Vandenbroucke, J. P.

    1995-01-01

    Recent concern about the safety of combined oral contraceptives (OCs) with third-generation progestagens prompted an examination of data from a population-based case-control study (Leiden Thrombophilia Study). We compared the risk of deep-vein thrombosis (DVT) during use of the newest OCs,

  15. An early 'handwritten' shell exchange catalogue of the Leiden Museum, with notes on the collectors Rethaan Macaré and Tischbein

    NARCIS (Netherlands)

    Bruggen, van A.C.

    2013-01-01

    A ‘handwritten’ (lithographed) shell exchange catalogue of the National Museum of Natural History, Leiden (The Netherlands), dated 1850 and containing 864 nominal taxa (861 molluscs and 3 brachiopods), is discussed in the context of the history of the museum. This catalogue must have been

  16. Influence of Factor V Leiden on susceptibility to and outcome from critical illness: a genetic association study

    DEFF Research Database (Denmark)

    Benfield, Thomas; Ejrnæs, Karen; Juul, Klaus

    2010-01-01

    ABSTRACT: INTRODUCTION: Disturbance of the pro-coagulatant and anti-coagulant balance is associated with a poor outcome from critical illness. The objective of this study is to determine whether the Factor V Leiden (FVL) mutation is associated with susceptibility to or death from critical illness....... METHODS: A genetic association study involving four case cohorts comprising two Gram negative sepsis, one invasive pneumococcal disease and one intensive care unit cohort with a total of 1,249 patients. Controls were derived from a population-based cohort study (N = 8,147). DNA from patients and controls...... not appear to increase the risk of admission due to severe invasive infections. Nevertheless, in the subgroup of patients admitted to intensive care an increased risk and a poorer long-term outcome for individuals with critical illness were observed for FVL mutation carriers....

  17. Teaching Engineering Ethics to PhD Students : A Berkeley–Delft Initiative: Commentary on “Ethics Across the Curriculum: Prospects for Broader (and Deeper) Teaching and Learning in Research and Engineering Ethics”

    NARCIS (Netherlands)

    Taebi, B.; Kastenberg, William E.

    2016-01-01

    A joint effort by the University of California at Berkeley and Delft University of Technology to develop a graduate engineering ethics course for PhD students encountered two types of challenges: academic and institutional. Academically, long-term collaborative research efforts between

  18. Exploring the use of automated vehicles as last mile connection of train trips through an agent-based simulation model: An application to Delft, Netherlands

    Directory of Open Access Journals (Sweden)

    Arthur Scheltes

    2017-06-01

    Full Text Available The last mile in a public transport trip is known to bring a large disutility for passengers, because the conventional transport modes for this stage of the trip can, in many cases, be rather slow, inflexible and not provide a seamless experience to passengers. Fully automated vehicles (AVs, that is, those which do not need a driver, could act as a first mile/last mile connection to mass public transport modes. In this paper, we study a system that we call Automated Last-Mile Transport (ALMT, which consists of a fleet of small, fully automated, electric vehicles to improve the last mile performance of a trip done in a train. An agent-based simulation model was proposed for the ALMT whereby a dispatching algorithm distributes travel requests amongst the available vehicles using a FIFO sequence and selects a vehicle based on a set of specified control conditions (e.g. travel time to reach a requesting passenger. The model was applied to the case-study of the connection between the train station Delft Zuid and the Technological Innovation Campus (Delft, The Netherlands in order to test the methodology and understand the performance of the system in function of several operational parameters and demand scenarios. The most important conclusion from the baseline scenario was that the ALMT system was only able to compete with the walking mode and that additional measures were needed to increase the performance of the ALMT system in order to be competitive with cycling. Relocating empty vehicles or allowing pre-booking of vehicles led to a significant reduction in average waiting time, whilst allowing passengers to drive at a higher speed led to a large reduction in average travel time, whilst simultaneously reducing system capacity as energy use is increased.

  19. An early (1850) 'handwritten' shell exchange catalogue of the Leiden Museum, with notes on the collectors Rethaan Macaré and Tischbein

    OpenAIRE

    Bruggen, van, A.C.

    2013-01-01

    A ‘handwritten’ (lithographed) shell exchange catalogue of the National Museum of Natural History, Leiden (The Netherlands), dated 1850 and containing 864 nominal taxa (861 molluscs and 3 brachiopods), is discussed in the context of the history of the museum. This catalogue must have been distributed in a limited edition to shell collectors interested in the exchange of specimens. Among the exchange partners of the museum were the well-known 19th century Dutch collector Lady (later Dowager) F...

  20. Macht, machinaties en musea. Jan van der Hoeven, Hermann Schlegel en hun strijd om het Rijksmuseum van natuurlijke historie te Leiden

    Directory of Open Access Journals (Sweden)

    H.L. de Jonge

    2005-01-01

    Full Text Available Might, machinations and museums. Jan van der Hoeven, Hermann Schlegel and their battle over the National Museum for Natural History in LeidenMuseums had a central place in nineteenth-century natural history. Aside from being important places for carrying out research into nature, they were also powerful vehicles for transmitting and communicating scientific knowledge. That is why, in the nineteenth century, natural history museums were frequently battlegrounds for rival scientists. Often, clashes over scientific matters were at the same time conflicts about power and space. After all, the naturalist who could get control over a museum’s collection and decide how the specimens should be classified and exhibited ultimately had the power to dictate which scientific knowledge was communicated; which story was told by a collection of specimens. This article is about the power struggle over the directorate of the National Museum of Natural History in Leiden that broke out between Jan van der Hoeven, Professor of Natural History and Comparative Anatomy at Leiden and Herman Schlegel, the museum’s chief curator. Both were rooted in very different natural historical traditions and had completely different views on the role of the museum and how the collection should be arranged and exhibited. In this article, we follow the two scientists in their attempts to gain support for their nominations. In this way, we also get a picture of nineteenth century Dutch political culture and the role scientists could play in it.

  1. Intravenous Remifentanil Analgaesia for an Obstetric Patient with Type I Neurofibromatosis and a Factor V Leiden Mutation

    Directory of Open Access Journals (Sweden)

    José L. Gálvez

    2018-01-01

    Full Text Available Type I neurofibromatosis is characterised by altered skin pigmentation and the growth of benign tumours, particularly along the peripheral nerves and central nervous system. We report a 36-year-old primigravida woman in labour who was admitted to the obstetric suite of the Hospital Sant Joan de Déu, Barcelona, Spain, in 2007 with hypothyroidism, type I neurofibromatosis and a factor V Leiden mutation. Due to a lack of cranial and spinal imaging data, an epidural was not indicated; instead, continuous intravenous remifentanil analgaesia was administered. The remifentanil infusion was self-titrated by the patient using a visual analogue scale, with the dosage ranging from 0.01 to 0.25 μg/kg/minute. Due to rotational dystocia, Kjelland-type forceps were used during the delivery. After birth, the infant was found to have Apgar scores of 9 and 10, with no maternal or neonatal adverse effects observed. Although still controversial, remifentanil may be a successful alternative for analgaesia in similar cases; however, the specific risks and benefits for each patient should be considered prior to administration.

  2. Timo de Rijk : 'We plant the seed'; interview

    NARCIS (Netherlands)

    De Rijk, T.; Bonger, S.

    2013-01-01

    Art historian Timo de Rijk was appointed Professor of Design, Culture and Society in Delft and Leiden last September. He calls this combination ‘a real breakthrough’. ‘Leiden University studies the workings of culture, while TU Delft aims at creating new things. These are fundamentally different

  3. Plasminogen activator inhibitor-1 4G/5G polymorphism, factor V Leiden, prothrombin mutations and the risk of VTE recurrence.

    Science.gov (United States)

    Sundquist, Kristina; Wang, Xiao; Svensson, Peter J; Sundquist, Jan; Hedelius, Anna; Larsson Lönn, Sara; Zöller, Bengt; Memon, Ashfaque A

    2015-11-25

    Plasminogen-activator inhibitor (PAI)-1 is an important inhibitor of the plasminogen/plasmin system. PAI-1 levels are influenced by the 4G/5G polymorphism in the PAI-1 promoter. We investigated the relationship between the PAI-1 polymorphism and VTE recurrence, and its possible modification by factor V Leiden (FVL) and prothrombin (PTM) mutations. Patients (n=1,069) from the Malmö Thrombophilia Study were followed from discontinuation of anticoagulant treatment until diagnosis of VTE recurrence or the end of the study (maximum follow-up 9.8 years). One hundred twenty-seven patients (11.9 %) had VTE recurrence. PAI-1 was genotyped by TaqMan PCR. Cox regression analysis adjusted for age, sex and acquired risk factors of VTE showed no evidence of an association between PAI-1 genotype and risk of VTE recurrence in the study population as a whole. However, by including an interaction term in the analysis we showed that FVL but not PTM modified the effect of PAI-1 genotype: patients with the 4G allele plus FVL had a higher risk of VTE recurrence [hazard ratio (HR) =2.3, 95 % confidence interval (CI) =1.5-3.3] compared to patients with the 4G allele but no FVL (reference group) or FVL irrespective of PAI-1 genotype (HR=1.8, 95 % CI=1.3-2.5). Compared to reference group, 5G allele irrespective of FVL was associated with lower risk of VTE recurrence only when compared with 4G allele together with FVL. In conclusion, FVL has a modifying effect on PAI-1 polymorphism in relation to risk of VTE recurrence. The role of PAI-1 polymorphism as a risk factor of recurrent VTE may be FVL dependent.

  4. Report on the International Workshop “The Golden Horde in a Global Perspective: Imperial Strategies”, Leiden University, May 7–8, 2015 »

    Directory of Open Access Journals (Sweden)

    Roman Hautala

    2015-09-01

    Full Text Available This article contains a report on the international conference organized by the University of Leiden in May 2015. According to its organizers, this conference has become the first Western European symposium dedicated to the study of the long history of the Golden Horde. The conference became a fruitful meeting place of the leading Russian and Tatar historians and archaeologists with their Western colleagues from the Netherlands, United Kingdom, United States of America, Hungary, Poland, and Finland. International participants of the Leiden conference discussed the most topical issues of historiography associated with eventful history of the Golden Horde. In particular, the conference participants paid special attention to the study of the administration of the ulus of Jochi that naturally combined governmental models of the Mongol Empire of the Chingizids with local administrative elements. A separate section of the conference was devoted to the analysis of the religious policy of the Golden Horde khans, where special attention was paid to the historiographical debate on the Islamization of the ulus of Jochi. The conference participants also paid considerable attention to the consideration of the material culture of the Golden Horde known both from written sources and, above all, from the materials of archaeological findings. Also, a number of reports of the confe­rence was devoted to foreign and domestic policies of the Golden Horde rulers, at the same time reflecting the central geopolitical role of the ulus of Jochi on the Eurasian continent and the high level of civilization of the Golden Horde. The main achievement of the Leiden conference was a statement on the need of deeper study of the Golden Horde history in order to overcome a number of stereotypes regarding misconceptions of the ulus of Jochi represented as backward and parasitic State formation. The conference participants agreed in general opinion about the necessity of similar

  5. Research Positioning & Trend Identification : a data-analytics toolbox

    NARCIS (Netherlands)

    Ranjbarsahraei, Bijan; Negenborn, R.R.

    2017-01-01

    AIDA was an initiative of TU Delft scientific staff in cooperation with TU Delft Library and Leiden University’s Centre for Science and Technology Studies (CWTS). The aim of the AIDA project was to provide TU Delft researchers and faculties with easy-to-use tools for research positioning and trend

  6. Association analysis of insulin-like growth factor-1 axis parameters with survival and functional status in nonagenarians of the Leiden Longevity Study

    DEFF Research Database (Denmark)

    van der Spoel, Evie; Rozing, Maarten P; Houwing-Duistermaat, Jeanine J

    2015-01-01

    Reduced insulin/insulin-like growth factor 1 (IGF-1) signaling has been associated with longevity in various model organisms. However, the role of insulin/IGF-1 signaling in human survival remains controversial. The aim of this study was to test whether circulating IGF-1 axis parameters associate...... with old age survival and functional status in nonagenarians from the Leiden Longevity Study. This study examined 858 Dutch nonagenarian (males≥89 years; females≥91 years) siblings from 409 families, without selection on health or demographic characteristics. Nonagenarians were divided over sex...

  7. The Frequency of Factor V Leiden, Prothrombin G20210A and Methylenetetrahydrofolate Reductase C677T Mutations in Migraine Patients

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    Ruhsen Öcal

    2010-12-01

    Full Text Available OBJECTIVE: Migraine is an independent risk factor for ischemic stroke, but its pathophysiology is still unclear. Genetic factors that predispose patients to thrombosis have been studied in patients with migraine to highlight the pathogenesis, but the results remain controversial. In this study, the frequencies of factor V Leiden (FVL, prothrombin (Pt G20210A and methylenetetrahydrofolate reductase (MTHFR C677T mutations were investigated. METHODS: One hundred and sixty patients aged of 15 to 55 years with no history of systemic disease and who had been diagnosed as migraine according to the International Headache Society (IHS diagnostic criteria at Baskent University Hospital Neurology Outpatient Clinics were investigated for FVL, Pt G20210A and MTHFR C677T mutations from their genomic DNA, and the results were compared with those of healthy controls. RESULTS: One hundred and fifty five (96.9% of 160 migraine patients were homozygote normal, 5 (3.1% were heterozygote and none of them were homozygote mutant for FVL. The control group had 9.8% heterozygote individuals but the difference between the percentages was not statistically significant (p> 0.05. There were no homozygote mutant individuals in the Turkish population study in normal subjects like our study. Thirty nine (24.4% of 160 migraine patients were heterozygote and 8 (5% were homozygote mutant for MTHFR C677T. The control group had 37 (34.9% heterozygote and 6 (5.6% homozygote mutant individuals. The difference between the percentages was not statistically significant (p= 0.15. Three (1.9% of 160 migraine patients were heterozygote and 5 (2.9% of the control group were heterozygote mutant for Pt G20210A mutation. The control group had 37 (34.9% heterozygote and 6 (5.6% homozygote mutant individuals. The difference between the percentages was not statistically significant (p= 0.420. CONCLUSION: Our study indicates that FVL, Pt G20210A and MTHFR C677T gene mutations, which are considered

  8. The Frequency of Factor V Leiden, Prothrombin G20210A and Methylenetetrahydrofolate Reductase C677T Mutations in Migraine Patients

    Directory of Open Access Journals (Sweden)

    Ruhsen Öcal

    2010-12-01

    Full Text Available OBJECTIVE: Migraine is an independent risk factor for ischemic stroke, but its pathophysiology is still unclear. Genetic factors that predispose patients to thrombosis have been studied in patients with migraine to highlight the pathogenesis, but the results remain controversial. In this study, the frequencies of factor V Leiden (FVL, prothrombin (Pt G20210A and methylenetetrahydrofolate reductase (MTHFR C677T mutations were investigated. METHODS: One hundred and sixty patients aged of 15 to 55 years with no history of systemic disease and who had been diagnosed as migraine according to the International Headache Society (IHS diagnostic criteria at Baskent University Hospital Neurology Outpatient Clinics were investigated for FVL, Pt G20210A and MTHFR C677T mutations from their genomic DNA, and the results were compared with those of healthy controls. RESULTS: One hundred and fifty five (96.9% of 160 migraine patients were homozygote normal, 5 (3.1% were heterozygote and none of them were homozygote mutant for FVL. The control group had 9.8% heterozygote individuals but the difference between the percentages was not statistically significant (p> 0.05. There were no homozygote mutant individuals in the Turkish population study in normal subjects like our study. Thirty nine (24.4% of 160 migraine patients were heterozygote and 8 (5% were homozygote mutant for MTHFR C677T. The control group had 37 (34.9% heterozygote and 6 (5.6% homozygote mutant individuals. The difference between the percentages was not statistically significant (p= 0.15. Three (1.9% of 160 migraine patients were heterozygote and 5 (2.9% of the control group were heterozygote mutant for Pt G20210A mutation. The control group had 37 (34.9% heterozygote and 6 (5.6% homozygote mutant individuals. The difference between the percentages was not statistically significant (p= 0.420. CONCLUSION: Our study indicates that FVL, Pt G20210A and MTHFR C677T gene mutations, which are considered

  9. A genetic study of Factor V Leiden (G1691A) mutation in young ischemic strokes with large vessel disease in a South Indian population.

    Science.gov (United States)

    Anadure, Ravi; Christopher, Rita; Nagaraja, Dindagur; Narayanan, Coimbatore

    2017-10-01

    Factor V Leiden (FVL) has been, by far, the most investigated gene mutation, with 26 studies to date, on its role in arterial strokes. Overall, a meta-analysis of all these studies taken together showed that carriers of the Factor V Leiden allele were 1.33times more likely to develop arterial strokes when compared to controls. We subjected a highly select subset of young strokes, with large vessel infarcts, to genetic analysis for FVL mutation and compared them with matched healthy controls to look for a statistically significant association. In this prospective study, 6/120 cases (5%) and 2/120 controls (1.6%) were positive for heterozygous FVL (G1691A) mutation. The higher prevalence of FVL mutation in cases (5%) compared to controls (1.6%) did not show statistical significance with a Pearson's Chi square P value of 0.15. The Odds Ratio (OR) for risk of large vessel disease in FVL positive cases was 3.10 (95% CI of 0.61-15.7). FVL mutation (G1691A) in young Indian subjects with ischemic strokes does not seem to be significantly associated with large vessel disease. Copyright © 2017 Elsevier Ltd. All rights reserved.

  10. Anécdotas castellanas en escritura hebraica. Apuntes paremiológicos conservados en las anotaciones hebreas de Alfonso de Zamora (Ms. Leiden Or. 645

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    Alonso Fontela, Carlos

    2011-12-01

    Full Text Available Problems of translation and interpretation are addressed in this presentation of Alfonso de Zamora’s Hebrew and Hebrew “Aljamiado” Spanish notes (ca. 1530 from Leiden University Library Ms. Or. 645 (ol. Warner 65 containing anecdotes, sayings and short tales. Additional notes dealing with a manuscript copy of the Targum to the Prophets comissioned by the University of Salamanca are also discussed.

    Este artículo estudia algunas notas manuscritas de Alfonso de Zamora en hebreo y en aljamía hebraico-castellana datadas hacia 1530, y procedentes del ms. Or. 645 (ol. Warner 65 de la Biblioteca de la Universidad de Leiden. Dichas notas contienen anécdotas, refranes y «cuentecillos», tales como las anécdotas «de fray Palomo», «de un portugués», y «de lo que dijo el gallego». Otras anotaciones de Zamora tratan de un trabajo de copia del Targum a los Profetas por encargo de la Universidad de Salamanca.

  11. Factor V Leiden mutation, prothrombin gene mutation, and deficiencies in coagulation inhibitors associated with Budd-Chiari syndrome and portal vein thrombosis: results of a case-control study

    NARCIS (Netherlands)

    Janssen, H. L.; Meinardi, J. R.; Vleggaar, F. P.; van Uum, S. H.; Haagsma, E. B.; van der Meer, F. J.; van Hattum, J.; Chamuleau, R. A.; Adang, R. P.; Vandenbroucke, J. P.; van Hoek, B.; Rosendaal, F. R.

    2000-01-01

    In a collaborative multicenter case-control study, we investigated the effect of factor V Leiden mutation, prothrombin gene mutation, and inherited deficiencies of protein C, protein S, and antithrombin on the risk of Budd-Chiari syndrome (BCS) and portal vein thrombosis (PVT). We compared 43 BCS

  12. Factor V Leiden mutation, prothrombin gene mutation, and deficiencies in coagulation inhibitors associated with Budd-Chiari syndrome and portal vein thrombosis : results of a case-control study

    NARCIS (Netherlands)

    Janssen, HLA; Meinardi, [No Value; Vleggaar, FP; van Uum, SHM; Haagsma, EB; van der Meer, FJM; van Hattum, J; Chamuleau, RAFM; Adang, RP; Vandenbroucke, JP; van Hoek, B; Rosendaal, FR

    2000-01-01

    In a collaborative multicenter case-control study, we investigated the effect of factor V Leiden mutation, prothrombin gene mutation, and inherited deficiencies of protein C, protein S, and antithrombin on the risk of Budd-Chiari syndrome (BCS) and portal vein thrombosis (PVT), We compared 43 BCS

  13. Arachidonic acid/docosahexaenoic acid-supplemented diet in early life reduces body weight gain, plasma lipids, and adiposity in later life in ApoE*3 Leiden mice

    NARCIS (Netherlands)

    Wielinga, P.Y.; Harthoorn, L.F.; Verschuren, L.; Schoemaker, M.H.; Jouni, Z.E.; Tol, E.A.F. van; Kleemann, R.; Kooistra, T.

    2012-01-01

    Scope: This study addresses whether early life arachidonic acid (ARA)/docosahexaenoic acid (DHA) supplementation or eicosapentaenoic acid (EPA)/DHA (Omacor) supplementation affects body weight gain, lipid metabolism, and adipose tissue quantity and quality in later life in ApoE*3Leiden-transgenic

  14. TU Delft en online media

    NARCIS (Netherlands)

    Speekenbrink, R.J.H.

    2013-01-01

    Dit boek behandelt een visie op online media bij Nederlandse universiteiten. Daarbij beperk ik me tot die aspecten waarin online communicatie en/of online marketing een rol speelt. Dit boek behandelt niet de onderwijsgerelateerde aspecten van online media. Elektronische leeromgevingen, sociale media

  15. The Trouble with Opium. Taste, Reason and Experience in Late Galenic Pharmacology with Special Regard to the University of Leiden (1575-1625).

    Science.gov (United States)

    Klerk, Saskia

    2014-01-01

    In the seventeenth century, the discrepancy between the taste of some drugs and their effects on the body was used to criticize Galenic medicine. In this paper, I argue that such contradictions were brought to light by the sixteenth-century study of drug properties within the Galenic tradition itself. Investigating how the taste of a drug corresponded to the effects it had on the body became a core problem for maintaining a medical practice that was both rational and effective. I discuss four physicians, connected to the University of Leiden, who attempted to understand drug properties, including taste, within a Galenic framework. The sixteenth-century discussions about the relationship between the senses, reason and experience, will help us understand the seventeenth-century criticism of Galenic medicine and the importance of discussions about materia medica for ideas regarding the properties of matter proposed in this period.

  16. Blood group AB and factor V Leiden as risk factors for pre-eclampsia: a population-based nested case-control study.

    Science.gov (United States)

    Hiltunen, Leena M; Laivuori, Hannele; Rautanen, Anna; Kaaja, Risto; Kere, Juha; Krusius, Tom; Paunio, Mikko; Rasi, Vesa

    2009-06-01

    Pre-eclampsia is an important cause of maternal morbidity and mortality. Its etiology is still unknown. Clinical symptoms correlate with activation of coagulation and inherited thrombophilia has been associated with pre-eclampsia. ABO blood group has been associated with thrombotic disorders and pre-eclampsia. We assessed ABO blood group, seven thrombophilia associated polymorphisms, and anti-beta2-glycoprotein I antibodies as risk factors for pre-eclampsia. We performed a population-based nested case-control study of 100,000 consecutive pregnancies in Finland. Cases and controls were identified by combining national registers and medical records were reviewed. We studied 248 cases fulfilling strict criteria for pre-eclampsia and 679 controls. Severe pre-eclampsia, early pre-eclampsia, and pre-eclampsia with intra-uterine growth restriction (IUGR) were analyzed separately. Blood group AB increased the risk for pre-eclampsia as a whole (OR 2.1, 95% CI 1.3-3.5), and in the three subgroups (OR 2.3, 3.8, 3.4; 95% CI 1.3-3.9, 2.0-7.1, 1.6-7.1). FV Leiden increased the risk as a whole (OR 1.7, 95% CI 0.8-3.9), and in the three subgroups, although not statistically significantly. Anti-beta2-glycoprotein I antibodies were not associated with pre-eclampsia. High body mass index, diabetes, first pregnancy, and twin pregnancy increased the risk from 1.5-fold to 8.2-fold. Our results confirm and extend the prior observation of blood group AB being a risk factor for pre-eclampsia. ABO blood group is known from all pregnant women. The value of blood group as risk factor for pre-eclampsia should be further assessed in prospective studies. In this study, FV Leiden was not statistically significant risk factor.

  17. The relationship of the factor V Leiden mutation or the deletion-deletion polymorphism of the angiotensin converting enzyme to postoperative thromboembolic events following total joint arthroplasty

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    Fang Carrie

    2001-04-01

    Full Text Available Abstract Background Although all patients undergoing total joint arthroplasty are subjected to similar risk factors that predispose to thromboembolism, only a subset of patients develop this complication. The objective of this study was to determine whether a specific genetic profile is associated with a higher risk of developing a postoperative thromboembolic complication. Specifically, we examined if the Factor V Leiden (FVL mutation or the deletion polymorphism of the angiotensin-converting enzyme (ACE gene increased a patient's risk for postoperative thromboembolic events. The FVL mutation has been associated with an increased risk of idiopathic thromboembolism and the deletion polymorphism of the ACE gene has been associated with increased vascular tone, attenuated fibrinolysis and increased platelet aggregation. Methods The presence of these genetic profiles was determined for 38 patients who had a postoperative symptomatic pulmonary embolus or proximal deep venous thrombosis and 241 control patients without thrombosis using molecular biological techniques. Results The Factor V Leiden mutation was present in none of the 38 experimental patients and in 3% or 8 of the 241 controls (p = 0.26. Similarly there was no difference detected in the distribution of polymorphisms for the ACE gene with the deletion-deletion genotype present in 36% or 13 of the 38 experimental patients and in 31% or 74 of the 241 controls (p = 0.32. Conclusions Our results suggest that neither of these potentially hypercoaguable states are associated with an increased risk of symptomatic thromboembolic events following total hip or knee arthroplasty in patients receiving pharmacological thromboprophylaxis.

  18. Cerebral infarction and femoral venous thrombosis detected in a patient with diabetic ketoacidosis and heterozygous factor V Leiden G1691A and PAI-1 4G/5G mutations.

    Science.gov (United States)

    Yaroglu Kazanci, Selcen; Yesilbas, Osman; Ersoy, Melike; Kihtir, Hasan Serdar; Yildirim, Hamdi Murat; Sevketoglu, Esra

    2015-09-01

    Cerebral infarction is one of the serious neurological complications of diabetic ketoacidosis (DKA). Especially in patients who are genetically prone to thrombosis, cerebral infarction may develop due to inflammation, dehydration, and hyperviscocity secondary to DKA. A 6-year-old child with DKA is diagnosed with cerebral infarction after respiratory insufficiency, convulsion, and altered level of consciousness. Femoral and external iliac venous thrombosis also developed in a few hours after central femoral catheter had been inserted. Heterozygous type of factor V Leiden and PAI-14G/5G mutation were detected. In patients with DKA, cerebral infarction may be suspected other than cerebral edema when altered level of consciousness, convulsion, and respiratory insufficiency develop and once cerebral infarction occurs the patients should also be evaluated for factor V Leiden and PAI-14G/5G mutation analysis in addition to the other prothrombotic risk factors.

  19. Wer sich den Göttern widersetzt, der stirbt jung : Untersuchung der Unvermeidbarkeit des Suizids in Die Leiden des jungen Werthers hinsichtlich der Strömung des „Sturm und Drang“

    OpenAIRE

    Andersson, Rasmus

    2015-01-01

    Der Ausgang des Romans Die Leiden des Jungen Werther (1774, von Johann Wolfgang von Goethe) wird beim ersten Anblick oft als tragische Folge einer unglücklichen und unerwiderten Liebe zu Lotte angesehen. In dieser vorliegenden Arbeit wird der weit erforschten Frage der Unvermeidbarkeit des Suizids im Werk eine alternative Deutung geliefert. Diese ist außerhalb des Romans angesiedelt, und zeigt, dass der Suizid schon in der Epoche angelegt ist.

  20. The association of factor V G1961A (factor V Leiden), prothrombin G20210A, MTHFR C677T and PAI-1 4G/5G polymorphisms with recurrent pregnancy loss in Bosnian women.

    Science.gov (United States)

    Jusić, Amela; Balić, Devleta; Avdić, Aldijana; Pođanin, Maja; Balić, Adem

    2018-08-01

    Aim To investigate association of factor V Leiden, prothrombin G20210A, MTHFR C677T and PAI-1 4G/5G polymorphisms with recurrent pregnancy loss in Bosnian women. Methods A total of 60 women with two or more consecutive miscarriages before 20 weeks of gestation with the same partners and without history of known causes or recurrent pregnancy loss were included. A control group included 80 healthy women who had one or more successful pregnancies without history of any complication which could be associated with miscarriages. Genotyping of factor V Leiden, prothrombin G20210A, MTHFR C677T and PAI-1 4G/5G polymorphisms were performed by polymerase chain reaction/restriction fragments length polymorphism method (PCR/RFLP). Results Both factor V Leiden and MTHFR C677T polymorphisms were significantly associated with recurrent pregnancy loss (RPL) in Bosnian women while prothrombin G20210A and PAI-1 4G/5G polymorphisms did not show strongly significant association. Conclusion The presence of thrombophilic polymorphisms may predispose women to recurrent pregnancy loss. Future investigation should be addressed in order to find when carriers of those mutations, polymorphisms should be treated with anticoagulant therapy. Copyright© by the Medical Assotiation of Zenica-Doboj Canton.

  1. A prepared speech in front of a pre-recorded audience: subjective, physiological, and neuroendocrine responses to the Leiden Public Speaking Task.

    Science.gov (United States)

    Westenberg, P Michiel; Bokhorst, Caroline L; Miers, Anne C; Sumter, Sindy R; Kallen, Victor L; van Pelt, Johannes; Blöte, Anke W

    2009-10-01

    This study describes a new public speaking protocol for youth. The main question asked whether a speech prepared at home and given in front of a pre-recorded audience creates a condition of social-evaluative threat. Findings showed that, on average, this task elicits a moderate stress response in a community sample of 83 12- to 15-year-old adolescents. During the speech, participants reported feeling more nervous and having higher heart rate and sweatiness of the hands than at baseline or recovery. Likewise, physiological (heart rate and skin conductance) and neuroendocrine (cortisol) activity were higher during the speech than at baseline or recovery. Additionally, an anticipation effect was observed: baseline levels were higher than recovery levels for most variables. Taking the anticipation and speech response together, a substantial cortisol response was observed for 55% of participants. The findings indicate that the Leiden Public Speaking Task might be particularly suited to investigate individual differences in sensitivity to social-evaluative situations.

  2. Lower blood pressure and apathy coincide in older persons with poorer functional ability: the Discontinuation of Antihypertensive Treatment in Elderly People (DANTE) Study Leiden.

    Science.gov (United States)

    Moonen, Justine E F; Bertens, Anne Suzanne; Foster-Dingley, Jessica C; Smit, Roelof A J; van der Grond, Jeroen; de Craen, Anton J M; de Ruijter, Wouter; van der Mast, Roos C

    2015-01-01

    To examine the association between blood pressure (BP) measures and symptoms of apathy and depression in older adults with various levels of functional ability. Cross-sectional study using baseline data from the Discontinuation of Antihypertensive Treatment in Elderly people (DANTE) Study Leiden. Primary care setting, the Netherlands. Community-dwelling individuals aged 75 and older (N = 430). Systolic BP (SBP), diastolic BP (DBP), and mean arterial pressure (MAP) were measured during home visits. Symptoms of apathy and depression were assessed using the Apathy Scale and the Geriatric Depression Scale (GDS-15), respectively. Stratified linear regression was performed in participants with better and worse functional ability according to the median of the Groningen Activity Restriction Scale. In participants with lower functional ability, each 10-mmHg lower SBP, DBP, and MAP was associated with higher Apathy Scale scores (0.63, 0.92, and 0.94 points, respectively, all P < .005) but not with GDS-15 scores. In participants with higher functional ability, BP measures were not associated with Apathy Scale or GDS-15 scores. In older participants with poorer functional ability, lower BP was associated with more symptoms of apathy but not depression. © 2015, Copyright the Authors Journal compilation © 2015, The American Geriatrics Society.

  3. Favorable glucose tolerance and lower prevalence of metabolic syndrome in offspring without diabetes mellitus of nonagenarian siblings: the Leiden longevity study.

    Science.gov (United States)

    Rozing, Maarten P; Westendorp, Rudi G J; de Craen, Anton J M; Frölich, Marijke; de Goeij, Moniek C M; Heijmans, Bastiaan T; Beekman, Marian; Wijsman, Carolien A; Mooijaart, Simon P; Blauw, Gerard-Jan; Slagboom, P Eline; van Heemst, Diana

    2010-03-01

    To explore measures of metabolic syndrome and glucose metabolism in families with exceptional longevity. Case-control study. A university hospital in Leiden, the Netherlands. One hundred twenty-one offspring of nonagenarian siblings, who were enriched for familial factors promoting longevity, and 113 of their partners. No subject had diabetes mellitus. Prevalence of metabolic syndrome was determined according to the criteria of the Third Report of the National Cholesterol Education Program. Glucose tolerance was assessed according to a 2-hour oral glucose tolerance test. The offspring of nonagenarians siblings had a lower prevalence of metabolic syndrome (P=.03), similar body composition, lower mean fasting blood glucose levels (4.99 vs 5.16 mmol/L; P=.01), lower mean fasting insulin levels (5.81 vs 6.75 mU/L; P=.04), a higher mean homeostasis model assessment of insulin sensitivity (0.78 vs 0.65; P=.02), and a more-favorable glucose tolerance (mean area under the receiver operating characteristic curve for glucose (13.2 vs 14.3; P=.007) than their partners. No significant differences were observed between the offspring and their partners in beta-cell function (insulogenic index 13.6 vs 12.5; P=.38). Despite similar body composition, the offspring of nonagenarian siblings showed a lower prevalence of metabolic syndrome and better glucose tolerance than their partners, centralizing the role of favorable glucose metabolism in familial longevity.

  4. Deep vein thrombosis, ecythyma gangrenosum and heparin-induced thrombocytopenia occurring in a man with a heterozygous Factor V Leiden mutation

    Directory of Open Access Journals (Sweden)

    Mariya Apostolova

    2012-11-01

    Full Text Available Skin necrosis and limb gangrene are occasional thrombotic manifestations of anticoagulation therapy. We report a man heterozygous for the Factor V Leiden (FVL mutation, and with a history of recurrent deep venous thrombosis, who initially presented with a necrotic skin lesion of the right flank while on warfarin therapy with a therapeutic international normalized ratio. Warfarin was discontinued and he received intravenous heparin. Thereafter he developed thrombocytopenia and pedal erythema and was diagnosed with heparin-induced thrombocytopenia (HIT. Heparin was replaced with argatroban. He ultimately underwent bilateral below-knee amputations for the thrombotic complications of the HIT. The initial necrotic lesion healed with antibiotics and wound care. Pathologic examination of multiple biopsy specimens revealed two separate lesions. One was necrotic tissue infiltrated with methicillin resistant Staphylococcus aureus having features of ecthyma gangrenosum. The second showed thrombotic changes consistent with HIT. The case illustrates the differential diagnosis of skin necrosis and limb gangrene in patients on warfarin and heparin, and also the clinical complexities that can occur in a FVL heterozygote.

  5. Las plantas vasculares de la Península Ibérica en la obra de Clusio: envíos de semillas de Sevilla a Leiden

    Directory of Open Access Journals (Sweden)

    Menéndez de Luarca, Luis Ramón-Laca

    1997-12-01

    Full Text Available Before 1575 Carolus Clusius visited Spain and Portugal, in what can be considered the first extensive botanical collection trip for the Iberian Peninsula. He published in 1576 Rariorum aliquot stirpium per Hispanias observatarum historia, mainly based on materials collected during that expedition. The content of this book was later merged with additional information to créate a more comprehensive work dealing with the whole European flora, Rariorum plantarum historiae, published in 1601. An important element in the generation of this second book was the collaboration of Simón de Tovar, from Seville, who contributed with shipments of seeds and bulbs to Clusius. Thanks to Tovar, the number of plants recorded in Rar. stirp. hispan, hist, was increased with some remarkable examples in Rar. pl. hist. It is particularly interesting to note that at that moment American plants were a great novelty and Seville was the gate for the introduction of most of them, i.e. Sprekelia formosissima (L. Herbert [• Amaryllis formosissima L.] or Psidium guajava L. A reconstruction of Clusius itinerary based on the collection localities is given in this paper. A discussion of the correspondence between both botanists, including a critical list of the plants sent to Leiden by Tovar is presented.Carolus Clusius, o sencillamente Clusio, visitó España y Portugal antes de 1575, en lo que puede considerarse la primera herborización sistemática de la Península Ibérica. En 1576 fue publicada en Amberes la obra Rariorum aliquot stirpium per Hispanias observatarum historia, basada fundamentalmente en el material colectado durante este viaje. Esta obra fue refundida posteriormente con información adicional en Rariorum plantarían historiae, publicada en 1601, que trataba de abarcar el conjunto de la flora europea. Un elemento importante en la génesis de esta segunda obra fue la colaboración del sevillano Simón de Tovar, quien contribuyó con envíos de semillas

  6. Predictive value of a profile of routine blood measurements on mortality in older persons in the general population: the Leiden 85-plus Study.

    Directory of Open Access Journals (Sweden)

    Anne H van Houwelingen

    Full Text Available BACKGROUND: Various questionnaires and performance tests predict mortality in older people. However, most are heterogeneous, laborious and a validated consensus index is not available yet. Since most older people are regularly monitored by laboratory tests, we compared the predictive value of a profile of seven routine laboratory measurements on mortality in older persons in the general population with other predictors of mortality; gait speed and disability in instrumental activities of daily living (IADL. METHODOLOGY/PRINCIPAL FINDINGS: Within the Leiden 85-plus Study, a prospective population-based study, we followed 562 participants aged 85 years for mortality over five years. At baseline (age 85 years high-density lipoprotein cholesterol, albumin, alanine transaminase, hemoglobin, creatinin clearance, C-reactive protein and homocysteine were measured. Participants were stratified based on their number of laboratory abnormalities (0, 1, 2-4 and 5-7. The predictive capacity was compared with gait speed (6-meter walking test and disability in IADL (Groningen Activity Restriction Scale by C-statistics. At baseline, 418 (74% 85-year old participants had at least one laboratory abnormality. All cause mortality risk increased with increasing number of laboratory abnormalities to a hazard ratio of 5.64 [95% CI 3.49-9.12] for those with 5-7 laboratory abnormalities (p<0.001 compared to those without abnormalities. The c-statistic was 0.66 [95% CI 0.59-0.69], similar to that of gait speed and disability in IADL. CONCLUSIONS/SIGNIFICANCE: In the general population of oldest old, the number of abnormalities in seven routine laboratory measurements predicts five-year mortality as accurately as gait speed and IADL disability.

  7. Impact of valvular heart disease on activities of daily living of nonagenarians: the Leiden 85-plus study a population based study.

    Science.gov (United States)

    van Bemmel, Thomas; Delgado, Victoria; Bax, Jeroen J; Gussekloo, Jacobijn; Blauw, Gerard J; Westendorp, Rudi G; Holman, Eduard R

    2010-04-01

    Data on the prevalence of valvular heart disease in very old individuals are scarce and based mostly on in-hospital series. In addition, the potential detrimental effect of valvular heart disease on the activities of daily living is unknown. The present study evaluated the prevalence of significant valvular heart disease and the impact of valvular heart disease on the activities of daily living in community dwelling nonagenarians. Nested within the Leiden 85-plus study, a population based follow-up study of the oldest old, a sample of 81 nonagenarians was recruited. The left ventricular (LV) dimensions, function and the presence and severity of heart valvular disease were evaluated by echocardiography. Significant valvular heart disease included any mitral or aortic stenosis severity, moderate or severe mitral regurgitation, moderate or severe aortic regurgitation and moderate or severe tricuspid regurgitation. Activities of daily living were assessed using the Groningen Activity Restriction Scale (GARS). LV cavity diameters (end-diastolic diameter 47 +/- 8 mm, end-systolic diameter 30 +/- 8 mm) and systolic LV function (LV ejection fraction 66 +/- 13%) were within normal for the majority of the participants. Significant valvular disease was present in 57 (70%) individuals, with mitral regurgitation and aortic regurgitation as the most frequent valve diseases (49% and 28% respectively). The GARS score between individuals with and without significant valvular heart disease was similar (36.2 +/- 9.2 vs. 34.4 +/- 13.2, p = 0.5). Nonagenarian, outpatient individuals have a high prevalence of significant valvular heart disease. However, no relation was observed between the presence of significant valvular heart disease and the ability to perform activities of daily living.

  8. Evaluation of Factor V Leiden, Prothrombin G20210A, MTHFR C677T and MTHFR A1298C gene polymorphisms in retinopathy of prematurity in a Turkish cohort.

    Science.gov (United States)

    Aydin, Hatip; Gunay, Murat; Celik, Gokhan; Gunay, Betul Onal; Aydin, Umeyye Taka; Karaman, Ali

    2016-12-01

    To assess Factor V Leiden (FVL) (rs6025), Prothrombin G20210A (rs1799963), MTHFR C677T (rs1801133), and MTHFR A1298C (rs1801131) gene mutations as risk factors in the development of retinopathy of prematurity (ROP). A total of 105 children were included in this cross-sectional study. Patients were divided into two groups. The study group consisted of 55 infants with a history of ROP and the control group comprised 50 healthy infants with term birth. All subjects were screened for the presence of certain mutations (FVL, Prothrombin G20210A, MTHFR C677T and MTHFR A1298C) by Real-Time PCR at 1 year of age. The mean gestational age (GA) and birth weight (BW) of the study group were, 28.65 ± 2.85 weeks and 1171 ± 385.74 g, respectively. There were no significant differences of genotype and allele frequency of Prothrombin G20210A, MTHFR A1298C and MTHFR C677T between the study and control groups (p > 0.05). Eight children (14.5 %) had heterozygous and one child (1.8%) had homozygous FVL mutation in the study group. One child (2%) in the control group had heterozygous FVL mutation. There was statistically significant differences of FVL allele and genotype frequencies between the groups (p < 0.05). The prevalence of FVL polymorphism (16.3 %) was higher in ROP patients than control subjects in this Turkish cohort. We suggest a possible association of FVL mutation with ROP at the end of the study.

  9. Thrombophilic Genetic Factors PAI-1, MTHFRC677T, V Leiden 506Q, and Prothrombin 20210A in Noncirrhotic Portal Vein Thrombosis and Budd-Chiari Syndrome in a Caucasian Population

    Directory of Open Access Journals (Sweden)

    Mario D’Amico

    2013-01-01

    Full Text Available Thrombophilic genetic factors PAI-1, MTHFRC677T, V Leiden 506Q, and Prothrombin 20210A were studied as risk factors in 235 Caucasian subjects: 85 patients with abdominal thrombosis (54 with portal vein thrombosis (PVT and 31 with Budd-Chiari syndrome (BCS without liver cirrhosis or hepatocellular carcinoma and 150 blood bank donors. Seventy-five patients with PVT/BCS showed associated disease or particular clinical status (46 PVT/29 BCS: 37 myeloproliferative neoplasm (20 PVT/17 BCS, 12 abdominal surgery (10 PVT/2 BCS, 10 contraception or pregnancy (6 PVT/4 BCS, 7 abdominal acute disease (6 PVT/1 BCS, and 9 chronic disease (4 PVT/5 BCS; ten patients did not present any association (8 PVT/2 BCS. PAI-14G-4G, MTHFR677TT, and V Leiden 506Q were significantly frequent (OR 95% CI and χ2 test with P value in abdominal thrombosis; in these patients PAI-14G-4G and MTHFR677TT distributions deviated from that expected from a population in the Hardy-Weinberg equilibrium (PAI-1: χ2=13.8, P<0.001; MTHFR677: χ2=7.1, P<0.01, whereas the equilibrium was respected in healthy controls. V Leiden Q506 and Prothrombin 20210A were in the Hardy-Weinberg equilibrium both in patients with abdominal thrombosis and healthy controls. Our study shows an important role of PAI-14G-4G and MTHFR677TT in abdominal thrombosis without liver cirrhosis or hepatocellular carcinoma.

  10. The frequency of β-globin gene haplotypes, α-thalassemia and genetic polymorphisms of methylenetetrahydrofolate reductase, factor V Leiden and prothrombin genes in children with sickle cell disease in Rio de Janeiro, Brazil Frequência dos haplótipos da globina beta, da talassemia alfa e dos polimorfismos genéticos dos genes da metilenotetrahidrofolato redutase, do fator V Leiden e da protrombina em crianças com doença falciforme no Rio de Janeiro, Brasil

    Directory of Open Access Journals (Sweden)

    Isaac L. Silva Filho

    2010-02-01

    Full Text Available A freqüência dos haplótipos beta S e beta C do gene da globina e a prevalência de talassemia alfa e de mutações nos genes da metilenotetrahidrofolato redutase (MTHFR-C677T, do fator V de Leiden e da protrombina (G20210A foi estudada em crianças com doença falciforme do Rio de Janeiro. O haplótipo Bantu foi o mais freqüente (65,9%, 21,2% das crianças (18% heterozigotas e 3% homozigotas apresentam talassemia com mutação alfa 3.7kb, ao contrário da mutação alfa 4.2kb que não foi encontrada. Os alelos 677CT e 677TT da MTHFR foram observados em 20,2% e 4,8%, respectivamente. Os haplótipos Camarões, Árabe-Indiano e Senegal não foram detectados na amostra estudada, bem como mutações no gene do fator V de Leiden e da protrombina. Somente o haplótipo beta C CI foi observado. Esse é o primeiro estudo realizado em uma amostra proveniente do Programa de Triagem Neonatal para Hemoglobinopatias do estado do Rio de Janeiro. Apesar do Rio de Janeiro ser a segunda maior cidade brasileira e seus habitantes expressarem o elevado grau de miscigenação ocorrida no país, nossos resultados ainda coincidem com os registros históricos dos fluxos migratórios do gene beta S para o Brasil, bem como refletem a forte influência de indivíduos de origem africana na população do Rio de Janeiro.

  11. Bιβλιοκρισία του: V. SYROS, Die Rezeption der aristotelischen politischen Philosophie bei Marsilius von Padua. Eine Untersuchung zur ersten Diktion des Defensor pacis [Studies in Medieval and Reformation Traditions, ed. by A. C. Gow, v. 134], Leiden, 2007

    Directory of Open Access Journals (Sweden)

    Στυλιανός ΛΑΜΠΑΚΗΣ

    2012-01-01

    Full Text Available   Βιβλιοκρισία του : V. SYROS, Die Rezeption der aristotelischen politischen Philosophie bei Marsilius von Padua. Eine Untersuchung zur ersten Diktion des Defensor pacis. [Studies in Medieval and Reformation Traditions, edited by Andrew Colin Gow, volume 134], Brill, Leiden-Boston 2007, σελ. X+364, ISSN 1573-4188

  12. Effects of probiotic Lactobacillus rhamnosus GG and Propionibacterium freudenreichii ssp. shermanii JS supplementation on intestinal and systemic markers of inflammation in ApoE*3Leiden mice consuming a high-fat diet.

    Science.gov (United States)

    Oksaharju, Anna; Kooistra, Teake; Kleemann, Robert; van Duyvenvoorde, Wim; Miettinen, Minja; Lappalainen, Jani; Lindstedt, Ken A; Kovanen, Petri T; Korpela, Riitta; Kekkonen, Riina A

    2013-07-14

    A high-fat diet disturbs the composition and function of the gut microbiota and generates local gut-associated and also systemic responses. Intestinal mast cells, for their part, secrete mediators which play a role in the orchestration of physiological and immunological functions of the intestine. Probiotic bacteria, again, help to maintain the homeostasis of the gut microbiota by protecting the gut epithelium and regulating the local immune system. In the present study, we explored the effects of two probiotic bacteria, Lactobacillus rhamnosus GG (GG) and Propionibacterium freudenreichii spp. shermanii JS (PJS), on high fat-fed ApoE*3Leiden mice by estimating the mast cell numbers and the immunoreactivity of TNF-α and IL-10 in the intestine, as well as plasma levels of several markers of inflammation and parameters of lipid metabolism. We found that mice that received GG and PJS exhibited significantly lower numbers of intestinal mast cells compared with control mice. PJS lowered intestinal immunoreactivity of TNF-α, while GG increased intestinal IL-10. PJS was also observed to lower the plasma levels of markers of inflammation including vascular cell adhesion molecule 1, and also the amount of gonadal adipose tissue. GG lowered alanine aminotransferase, a marker of hepatocellular activation. Collectively, these data demonstrate that probiotic GG and PJS tend to down-regulate both intestinal and systemic pro-inflammatory changes induced by a high-fat diet in this humanised mouse model.

  13. [A clinical case of young, oral combined contraceptive using women, heterozygous carrier of the Factor V (Leiden) which revealed thrombosis of the left internal jugular vein and brain ischemia with cerebral infarction and ischemic stroke].

    Science.gov (United States)

    Kovachev, S; Ramshev, K; Ramsheva, Z; Ivanov, A; Ganovska, A

    2013-01-01

    Thrombophilia is associated with increased risks of venous thrombosis in women taking oral contraceptive preparations. Universal thrombophilia screening in women prior to prescribing oral contraceptive preparations is not supported by current evidence. The case is presented of a 23 year-old women with a personal history of interruption and on the same day started with oral contraceptive (0.03 microg ethynil estradiol - 0.075 microg gestodene), which due on a 18 pill/day to acute headache, increasing vomiting and speaking defects. Physical/neurologic/gynecologic examinations observed a normal status. The MRI and CT revealed thrombosis of the left internal jugular vein and brain ischemia with cerebral infarction and ischemic stroke. The acute therapy of thrombotic findings was accompanied with many tests. The thrombophilia PCR-Real time - test finds heterozygous carrier of the Factor V (Leiden). This case shows the need of large prospective studies that should be undertaken to refine the risks and establish the associations of thrombophilias with venous thrombosis among contraceptive users. The key to a prompt diagnosis is to know the risk factors. The relative value of a thrombophilia screening programme before contraceptive using needs to be established.

  14. Extra-Virgin Olive Oil with Natural Phenolic Content Exerts an Anti-Inflammatory Effect in Adipose Tissue and Attenuates the Severity of Atherosclerotic Lesions in Ldlr-/-.Leiden Mice.

    Science.gov (United States)

    Luque-Sierra, Amparo; Alvarez-Amor, Leticia; Kleemann, Robert; Martín, Franz; Varela, Lourdes M

    2018-05-15

    The present study investigates the effect of olive oils with different phenolic content in high-fat diets (HFDs) on hypertrophy and inflammation in adipose tissue and associated atherosclerosis, in the context of obesity. Ldlr-/-.Leiden mice were fed three different HFDs for 32 weeks and were compared with mice fed the standard low-fat diet (LFD). The different fats provided in the HFDs were lard (HFD-L), extra-virgin olive oil (EVOO; 79 mg kg -1 of phenolic compounds, HFD-EVOO), or EVOO rich in phenolic compounds (OL, 444 mg kg -1 of phenolic compounds, HFD-OL). All HFD-fed mice became obese, but only HFD-L-induced adipocyte hypertrophy. HFD-EVOO mice exhibited the greatest levels of Adiponectin in adipose tissue and presented atherosclerotic lesions similar to the LFD group, with a very low count of monocyte/macrophage compared with HFD-L and HFD-OL mice. Enrichment of the phenolic content of olive oil reduced the secretion of nitrites/nitrates in the aorta, but atherosclerosis was not attenuated in HFD-OL mice compared to other HFD mice. Consumption of olive oil with a natural content of phenolic compounds attenuates adipose tissue hypertrophy and inflammation and exerts antiatherosclerotic effects in mice. A higher phenolic content of olive oil did not provide further benefits in the prevention of atherosclerosis. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  15. Learning about Factor V Leiden Thrombophilia

    Science.gov (United States)

    ... Care Genomic Medicine Working Group New Horizons and Research Patient Management Policy and Ethics Issues Quick Links for Patient Care Education All About the Human Genome Project Fact Sheets Genetic Education Resources for ...

  16. Liebe ohne Leiden? Love without Sorrows?

    Directory of Open Access Journals (Sweden)

    Stefan Müller

    2008-11-01

    Full Text Available Im vorliegenden Sammelband werden unterschiedliche Zugänge und Herangehensweisen zum Thema ‚Liebe im Kapitalismus‘ nebeneinandergestellt. Die Idee der Liebe innerhalb der ‚Logik des Kapitalismus‘ soll genauer untersucht werden. Dafür werden Erfahrungen und Reflexionen aus Kunst, Literatur, Philosophie und Psychoanalyse sowie aus Datenerhebungen und Interviews herangezogen und analysiert. Die Beiträge gruppieren sich zumeist allerdings stärker um das Themenfeld der Liebe. Veränderungen der kapitalistischen Logik nachzuzeichnen, wird in den Ausführungen kaum angestrebt.The volume at hand compares varying approaches to the theme of ‘love under capitalism.’ The intention is to more closely examine the idea of love within the ‘logic of capitalism.’ In order to achieve this, experiences and reflections from art, literature, philosophy, and psychoanalysis as well as data collections and interviews are drawn out and analyzed. The contributions, however, are mostly grouped around the thematic of love. Most of the studies barely begin to sketch the changes of capitalist logic.

  17. Ruimtelijke transformaties van de steden in het Randstadgebied (12de-20ste eeuw) : Een vergelijkende analyse van de stadsplattegronden

    NARCIS (Netherlands)

    Zweerink, K.A.

    2017-01-01

    In this study, the transformation of the form of nine cities in the Randstad between 1250 and 1940 in relation to changes in infrastructure is central, namely Utrecht, Dordrecht, Leiden, Haarlem, Delft, Gouda, Amsterdam, Rotterdam and The Hague. Within this time span three periods of great spatial

  18. Going Dutch: Higher Education in the Netherlands

    Science.gov (United States)

    Law, David

    2016-01-01

    This article outlines some of the policy issues currently faced by research-based universities in the Netherlands. The focus is on four leading universities (University of Amsterdam: UvA; Free University of Amsterdam: VU; Leiden University; and Delft University of Technology: TUD). The author visited these institutions as part of a Study Tour…

  19. Assessment of Delft3D Morphodynamic Model During Duck94

    National Research Council Canada - National Science Library

    Welsch, Charlotte

    2002-01-01

    ... over a wide range of conditions. The Delfi3D 2- DH model utilizes shallow water equations to phase resolve the mean and infragravity motions in combination with an advection diffusion equation for the sediment transport...

  20. Evaluation of Delft3D Performance in Nearshore Flows

    National Research Council Canada - National Science Library

    Hsu, Y. L; Dykes, James D; Allard, Richard A; Kaihatu, James M

    2006-01-01

    .... All three bottom friction formulations, i.e., Chezy, White-Colebrook, and Manning, are evaluated and all can produce good longshore current results, if proper empirical bottom friction coefficient is used. The RMS error for longshore current is about 0.2 m/s.

  1. Changing culture - the experience of TU Delft Library

    NARCIS (Netherlands)

    Heijne, M.; Van der Sar, E.

    2004-01-01

    When seeking to introduce change into an organisation, it is usually the organisational structure that is the main focus of attention. A reorganisation, however, does not necessarily resolve underlying cultural problems. It can, in fact, be just these cultural problems that prevent the organisation

  2. DUNBID, the Delft University neutron backscattering imaging detector

    International Nuclear Information System (INIS)

    Bom, V.R.; Eijk, C.W.E. van; Ali, M.A.

    2005-01-01

    In the search for low-metallic land mines, the neutron backscattering technique may be applied if the soil is sufficiently dry. An advantage of this method is the speed of detection: the scanning speed may be made comparable to that of a metal detector. A two-dimensional position sensitive detector is tested to obtain an image of the back scattered thermal neutron radiation. Results of experiments using a radionuclide neutron source are presented. The on-mine to no-mine signal ratio can be improved by the application of a window on the neutron time-of-flight. Results using a pulsed neutron generator are also presented

  3. On Rhinoceros simus, Burchell in the Leiden Museum

    NARCIS (Netherlands)

    Jentink, F.A.

    1890-01-01

    According to Dr. P. L. Sclater (Nature, September 25, 1890, p. 520) Mr. F. Selous says in the Field of August 16 as follows: — »it was within a mile of this spot that, two years previously (i. e. in 1888), I shot two white Rhinoceroses Rhinoceros simus), the last of their kind that have been killed

  4. Prevalence of activated protein C resistance (Factor V Leiden) in ...

    African Journals Online (AJOL)

    Four (67%) of the six subjects with APCr were non-O blood group. Whereas only two (0.9%) of 226 non-A subjects (blood groups 0 and B) had APCr, 4 (6%) of 71 subjects with A gene (blood groups A and AB) had APCr. The inheritance of A gene appears to constitute a risk to inheritance of APCr (P = 0.03). No association ...

  5. HI shells in the Leiden-Dwingeloo HI survey

    Czech Academy of Sciences Publication Activity Database

    Ehlerová, Soňa; Palouš, Jan; Wünsch, Richard

    2004-01-01

    Roč. 289, 3-4 (2004), s. 279-282 ISSN 0004-640X. [From observations to self-consistent modelling of the ISM in galaxies. Porto, 02.09.2002-07.09.2002] R&D Projects: GA AV ČR IAB3003106 Institutional research plan: CEZ:AV0Z1003909 Keywords : HI shells * HI holes Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics Impact factor: 0.597, year: 2004

  6. Italiaans stucwerk in Den Haag en Leiden 1700-1800

    NARCIS (Netherlands)

    Jager, G.W.M.; Fock, C.W.

    1984-01-01

    Italiaanse stucwerkers waren reeds in de 17de eeuw in heel Europa beroemd, maar pas aan het eind van die eeuw, toen de tendens naar hogere en lichtere kamers ook in Holland doordrong, kwam stucwerk in de mode. In de vertrekken beperkte de rol zich hoofdzakelijk tot de plafonds, in de gangen en

  7. Factor V Leiden Mutation and PT 20210 Mutation Test

    Science.gov (United States)

    ... Disorders Fibromyalgia Food and Waterborne Illness Fungal Infections Gout Graves Disease Guillain-Barré Syndrome Hashimoto Thyroiditis Heart ... Tested? To determine whether you have an inherited gene mutation that increases your risk of developing a ...

  8. Canonische data-analyse : leiden verschillende procedures tot verschillende resultaten ?

    NARCIS (Netherlands)

    Vogelesang, A.W. Verhoef, P.J.G. & Oppe, S.

    2000-01-01

    Concerning the analysis of problems in road safety, the classical techniques for multivariate analysis are often not applicable. Non-linear canonical analysis can be used, when one wants to study the relations between non-linear characteristics. A canonical analysis can take place, according to

  9. HI shells in the Leiden/Argentina/Bonn HI survey

    Czech Academy of Sciences Publication Activity Database

    Ehlerová, Soňa; Palouš, Jan

    2013-01-01

    Roč. 550, February (2013), A23/1-A23/9 ISSN 0004-6361 R&D Projects: GA ČR GAP209/12/1795 Institutional support: RVO:67985815 Keywords : ISM bubbles * ISM general Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics Impact factor: 4.479, year: 2013

  10. Innovative collection development for e-books at the TU Delft Library

    NARCIS (Netherlands)

    Brinkman Dzwig, Z.E.

    2013-01-01

    Thanks to new technologies libraries worldwide go digital and are accessible 24/7 from remote locations. The innovation is even more visible in traditional library tasks such as collection development and acquisitions. Those tasks are undergoing rapid transformation as well. One of the reasons is

  11. Fire safety aspects in cultural heritage : a case study in historical Delft

    NARCIS (Netherlands)

    Öhlin Lostetter, S.M.; Breunese, A.J.

    2005-01-01

    Fire is an important threat to cultural heritage. Therefore 12 fire laboratories and consultants across the EU have joined together for the European Thematic-Network Fire Risk Evaluation to European Cultural Heritage (Fire-Tech). The final goal of this thematic network was to develop a decision

  12. Application of the Delft Numerical models in the Lower Yellow River

    NARCIS (Netherlands)

    De Vriend, H.J.; Wang, Z.B.; Winterwerp, H.; Visser, P.J.; Sloff, C.J.; Liu, H.L.; Liang, G.T.; Wu, S.Q.; Ji, Z.W.

    2002-01-01

    Because of heavy deposition and water shortage, the Yellow River faces the risk of flooding and no-flow since the middle of 1980s. The problem could be solved only by integrated water management. However, Dutch has a long history fighting the flood and gets a lot of experiences in water management,

  13. Delfts blauwe dood: de gevolgen van de cholera in de negentiende eeuw

    NARCIS (Netherlands)

    Ekamper, P.; Buzing, G.

    2013-01-01

    Cholera-epidemieën waren in de 19de eeuw verantwoordelijk voor vele dodelijke slachtoffers. De ziekte maakte bovendien geen onderscheid tussen arm en rijk. Normaal gesproken relatief minder kwetsbare groepen in die tijd, zoals wat oudere kinderen en jongere volwassenen, liepen juist een groter

  14. Voorlichting voor het verkeer. Syllabus College Verkeerstechniek T.H. Delft.

    NARCIS (Netherlands)

    Schreuder, D.A.

    1980-01-01

    After a general introduction (1) on the human eye, photometry and sources of light, the report deals with the functional aspects of public lighting (2), its design (3), and the cost benefit analysis (4). In chapter 2 the function of traffic provisions in general and those of traffic lighting are

  15. Delft3D-Modelling of Hydrodynamic and Water Quality Processes in San Diego Bight

    Science.gov (United States)

    2010-09-30

    Terrill (SIO Scripps), Dr. Lyle Hibler ( PNL ) and Mark Moline (CalPoly) who are funded separately. LONG-TERM GOALS The long-term goal of this effort is...October 3, 2002. RELATED PROJECTS This work is a cooperation with Dr. Eric Terrill (SIO Scripps), Dr. Lyle Hibler ( PNL ) and Mark Moline (CalPoly) who are funded separately. 5

  16. Aging of Asphalt Symposium, September 17th 2014, Delft, the Netherlands

    NARCIS (Netherlands)

    Erkens, S.M.J.G.; Scarpas, A.; Blab, R.; Glaser, R.; Glover, C.; Oeser, M.; Porot, L.; Soenen, H.

    2015-01-01

    Technical specifications for the asphalt concrete properties are developed to be able to specify mixtures that will perform well in pavement applications. Being able to identify and determine properties related to pavement performance in practice is crucial for both road authorities and contractors,

  17. Aging of Asphalt Symposium : Delft, the Netherlands September 17th 2014

    NARCIS (Netherlands)

    Erkens, Sandra; Scarpas, Athanasios

    2015-01-01

    Technical specifications for the asphalt concrete properties are developed to be able to specify mixtures that will perform well in pavement applications. Being able to identify and determine properties related to pavement performance in practice is crucial for both road authorities and contractors,

  18. Bean counting : Fair trade, Delft Reactor Institute shoots neutrons at coffee beans

    NARCIS (Netherlands)

    Schrauwers, A.

    2003-01-01

    Apart from oil, coffee is the worlds most important export product. The large-scale intensive coffee plantations are also one of the worlds biggest users of pesticides. But cautious signs are emerging of return to the traditional, practically pesticide-free, organic growing methods, a trend that

  19. A safer road environment for cyclists. Proefschrift Technische Universiteit Delft TUD.

    NARCIS (Netherlands)

    Schepers, P.

    2013-01-01

    This thesis focuses on the question of how the road environment (road design and network characteristics) affects road safety for cyclists through effects on risk and exposure to risk. In this thesis, the term ‘road design’ is used to denote the location level (e.g. intersection design) while the

  20. Push or Pull Students into Blended Education A Case Study at Delft University of Technology

    NARCIS (Netherlands)

    Cervone, A.; Melkert, J.A.; Mebus, L.F.M.; Saunders, G.N.

    2016-01-01

    Blended education, or “flipping the classroom” is rapidly becoming a mainstream form of teaching within universities. Within Engineering Education, it is popular as it allows more time in-class to focus on hands on activities such as demonstrations and solving complex problems. This paper discusses

  1. Green micro-resistojet research at Delft University of Technology: the new frontiers of Cubesat propulsion

    NARCIS (Netherlands)

    Cervone, A.; Zandbergen, B.T.C.; Cordeiro Guerrieri, D. C.; de Athayde Costa e Silva, Marsil A. C.; van Zeijl, H.W.

    2016-01-01

    The aerospace industry is recently expressing a growing interest in green, safe and non-toxic propellants for the propulsion systems of the new generation of space vehicles, which is especially true in the case of Cubesat micro-propulsion systems. Demanding requirements are associated to the future

  2. Delft Aerospace Design Projects 2016 : Inspring Designs in Aeronautics, Astronautics and Wind Energy

    NARCIS (Netherlands)

    Melkert, J.A.

    2016-01-01

    This book presents an overview of the results of the Fall Design Synthesis Exercise 2015 and the Spring Design Synthesis Exercise of 2016, based on summaries of each of the projects. The Design Synthesis Exercise Coordination Committee, responsible for the organisation and execution of the exercise,

  3. Delft Aerospace Design Projects 2015 : Challenging New Designs in Aeronautics, Astronautics and Wind Energy

    NARCIS (Netherlands)

    Melkert, J.A.

    2015-01-01

    This book presents an overview of the results of the Fall Design Synthesis Exercise 2014 and the Spring Design Synthesis Exercise of 2015, based on summaries of each of the projects. The Design Synthesis Exercise Coordination Committee, responsible for the organisation and execution of the exercise,

  4. Delft Aerospace Design Projects 2014 : New Designs in Aeronautics, Astronautics and Wind Energy

    NARCIS (Netherlands)

    Melkert, J.A.

    2014-01-01

    This book presents an overview of the results of the Fall Design Synthesis Exercise 2013 and the Spring Design Synthesis Exercise of 2014, based on summaries of each of the projects. The Design Synthesis Exercise Coordination Committee, responsible for the organisation and execution of the exercise,

  5. Biotechnology in developing countries : Proceedings of the symposium, Delft, The Netherlands, 13-14 October 1982

    NARCIS (Netherlands)

    Van Hemert, P.A.; Lelieveld, H.L.M.; La Rivière, J.W.M.

    1983-01-01

    Biotechnology in Developing Countries aims to be more than the cleverly chosen combination of two hot topics of today. It is obvious that Biotechnology, as the technology of using microorganisms and tissue cells, has certain intrinsic advantages over other technologies in the setting of a Developing

  6. Validation of Delft3D as a Coastal Surge and Inundation Prediction System

    Science.gov (United States)

    2016-04-07

    control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 5d. PROJECT NUMBER...H. Holthuijsen, R. A. Luettich Jr., M. D. Powell, V. J. Cardone , A. T. Cox, H. Pourtaheri, H. J. Roberts, J. H. Atkinson, S. Tanaka, H. J

  7. Grondwatereffecten aan de oppervlakte (gebracht) : Onderzoek naar effecten van stopzetting grondwaterontrekking DSM Delft - Technisch rapport

    NARCIS (Netherlands)

    Buma, J.; Van Gessel, S.; Goes, B.; De Lange, G.; Van Meerten, H.; Van Oostrom, N.; Oude Essink, G.; Weiland, F.S.; Veldkamp, H.; Vergroesen, T.; Verkaik, J.; Gehrels, H.; Roelofsen, F.; Goorden, N.

    2008-01-01

    Deze rapportage bevat de beschrijving van de afzonderlijke modellen en is om die reden opgebouwd uit 5 delen. Deel I beschrijft de totstandkoming van de geo(hydro)logie van de ondergrond. Daarbij wordt onderscheid gemaakt tussen Pleistoceen en Holoceen waarbij het Holoceen zowel regionaal als ook in

  8. Slurry Transport : Fundamentals, a historical overview and the Delft Head Loss & Limit Deposit Velocity Framework

    NARCIS (Netherlands)

    Miedema, S.A.; Ramsdell, RC

    2016-01-01

    In dredging, trenching, (deep sea) mining, drilling, tunnel boring and many other applications, sand, clay or rock has to be excavated. After the soil has been excavated it is usually transported hydraulically as a slurry over a short (TSHD’s) or a long distance (CSD’s). Estimating the pressure

  9. Managing the risks of a large-scale infrastructure project : The case of Spoorzone Delft

    NARCIS (Netherlands)

    Priemus, H.

    2012-01-01

    Risk management in large-scale infrastructure projects is attracting the attention of academics and practitioners alike. After a brief summary of the theoretical background, this paper describes how the risk analysis and risk management shaped up in a current large-scale infrastructure project in

  10. The Delft Filtration Characterisation method : Assessing membrane bioreactor activated sludge filterability

    NARCIS (Netherlands)

    Geilvoet, S.P.

    2010-01-01

    Clean water is becoming a scarce resource. As a consequence reclaimed wastewater can be an attractive alternative to replace existing water resources for non-potable reuse options. In order to achieve this goal advanced treatment technologies are required. An example of such technology is the

  11. Valuing Craftsmanship: In particular the crafting of Chinese porcelain and Dutch Delft Blue

    NARCIS (Netherlands)

    L. Jiang (Lili)

    2018-01-01

    markdownabstract“How important are crafts for a society?” When a conventional economist gets the question, the answer is most likely about the prices of craft products, the income of craftspeople, and the contribution that the crafts sector makes to GDP. This thesis gives another answer. Applying

  12. Pancreatic adenocarcinoma, chronic pancreatitis, and MODY-8 diabetes: is bile salt-dependent lipase (or carboxyl ester lipase) at the crossroads of pancreatic pathologies?

    Science.gov (United States)

    Lombardo, Dominique; Silvy, Françoise; Crenon, Isabelle; Martinez, Emmanuelle; Collignon, Aurélie; Beraud, Evelyne; Mas, Eric

    2018-02-23

    Pancreatic adenocarcinomas and diabetes mellitus are responsible for the deaths of around two million people each year worldwide. Patients with chronic pancreatitis do not die directly of this disease, except where the pathology is hereditary. Much current literature supports the involvement of bile salt-dependent lipase (BSDL), also known as carboxyl ester lipase (CEL), in the pathophysiology of these pancreatic diseases. The purpose of this review is to shed light on connections between chronic pancreatitis, diabetes, and pancreatic adenocarcinomas by gaining an insight into BSDL and its variants. This enzyme is normally secreted by the exocrine pancreas, and is diverted within the intestinal lumen to participate in the hydrolysis of dietary lipids. However, BSDL is also expressed by other cells and tissues, where it participates in lipid homeostasis. Variants of BSDL resulting from germline and/or somatic mutations (nucleotide insertion/deletion or nonallelic homologous recombination) are expressed in the pancreas of patients with pancreatic pathologies such as chronic pancreatitis, MODY-8, and pancreatic adenocarcinomas. We discuss the possible link between the expression of BSDL variants and these dramatic pancreatic pathologies, putting forward the suggestion that BSDL and its variants are implicated in the cell lipid metabolism/reprogramming that leads to the dyslipidemia observed in chronic pancreatitis, MODY-8, and pancreatic adenocarcinomas. We also propose potential strategies for translation to therapeutic applications.

  13. High blood pressure at old age : The Leiden 85 plus study

    NARCIS (Netherlands)

    Bemmel, Thomas van

    2010-01-01

    The last decades have shown an increasing interest in treatment of high blood pressure. Copious amounts of data have been published on the mortality and morbidity risks of high blood pressure. Overall these data have resulted in an increasing awareness of the deleterious effects of only modest

  14. A systematic catalogue of the Coleopterous family Helotidae in the Leiden Museum

    NARCIS (Netherlands)

    Ritsema, C.

    1915-01-01

    Gen. HELOTA Mc L.1) Mc Leay, Annulosa Javanica, 1825, p. 42; ed. Lequien, 1833, p. 151. INDOMALAYAN SPECIES. (Nos. 1—69). 1. Vigorsi Mc L. Annul. Javan. 1825, p. 43, tab. 1, fig. 9; ed. Lequien, 1833, p. 152, tab. 5, fig. 4. a. ♀. Java or.: Mt. Ardjoeno (W. E. J. Hekmeyer). b. ♀. Java (A. B. v.

  15. Species of Ganoderma and related genera mainly of the Bogor and Leiden Herbaria

    NARCIS (Netherlands)

    Steyaert, R.L.

    1972-01-01

    This contribution to the knowledge of the Aphyllophorales is dedicated to Dr. M. A. Donk as a tribute to his life-long endeavour to put the systematics and the taxonomy of this challenging order on a sound basis. A collection of South Asian specimens of Ganoderma and various other collections have

  16. Familial Longevity Is Marked by Better Cognitive Performance at Middle Age: The Leiden Longevity Study

    NARCIS (Netherlands)

    Stijntjes, M.; Craen, A.J.M.; van Heemst, D.; Meskers, C.G.M.; van Buchem, M.A.; Westendorp, R.G.J.; Slagboom, P.E.; Maier, A.B.

    2013-01-01

    Background: Decline in cognitive performance is a highly prevalent health condition in elderly. We studied whether offspring of nonagenarian siblings with a familial history of longevity, perform better on cognitive tests compared to their partners as controls. This is relevant since it could

  17. Printed and Mimeographed Issues Obtainable from Flora Malesiana Foundation, Rijksherbarium, Leiden

    NARCIS (Netherlands)

    NN,

    1967-01-01

    Index to the Enumeration of the Orchidaceae of Sumatra, by J.J. Smith. At the Rijksherbarium there was a handwritten copy compiled by the late Dr. J.J. Smith of his important enumeration of Sumatran Orchids, published in Fedde, Repertorium 32 (1933) 130-386, which was obviously for reasons of

  18. Dietary sphingolipids lower plasma cholesterol and triacylglycerol and prevent liver steatosis in APOE*3Leiden mice

    NARCIS (Netherlands)

    Duivenvoorden, Ilse; Voshol, Peter J.; Rensen, Patrick C. N.; van Duyvenvoorde, Wim; Romijn, Johannes A.; Emeis, Jef J.; Havekes, Louis M.; Nieuwenhuizen, Willem F.

    2006-01-01

    The prevalence of dyslipidemia and obesity resulting from excess energy intake and physical inactivity is increasing. The liver plays a pivotal role in systemic lipid homeostasis. Effective, natural dietary interventions that lower plasma lipids and promote liver health are needed. Our goal was to

  19. Dietary sphingolipids lower plasma cholesterol and triacylglycerol and prevent liver steatosis in APOE*3Leiden mice

    NARCIS (Netherlands)

    Duivenvoorden, I.; Voshol, P.J.; Rensen, P.C.N.; Duyvenvoorde, W. van; Romijn, J.A.; Emeis, J.J.; Havekes, L.M.; Nieuwenhuizen, W.F.

    2006-01-01

    Background: The prevalence of dyslipidemia and obesity resulting from excess energy intake and physical inactivity is increasing. The liver plays a pivotal role in systemic lipid homeostasis. Effective, natural dietary interventions that lower plasma lipids and promote liver health are needed.

  20. From Innovation Community to Community Innovation User-initiated Innovation in Wireless Leiden

    NARCIS (Netherlands)

    van Oost, Elizabeth C.J.; Verhaegh, Stefan; Oudshoorn, Nelly E.J.

    2009-01-01

    The role of users in innovation processes has gained increasing attention in innovation studies, technology studies, and media studies. Scholars have identified users and use practices as a source of innovation. So far, however, little insight has been generated in innovation processes in which

  1. Clinical gait analysis : A review of research at the Interdepartmental Research group of Kinesiology in Leiden

    NARCIS (Netherlands)

    Daanen, H. A M

    1990-01-01

    In this article the methodology used in the Interdepartmental Research Group of Kinesiology to quantify (clinical) human gait is elaborated upon. Four methods are described: analysis of temporal parameters, goniometry, accelerometry and electromyography. A correct representation of electromyographic

  2. The gem collection of the Rijksmuseum van Geologie en Mineralogie of Leiden The Peridots

    NARCIS (Netherlands)

    Zwaan, P.C.

    1957-01-01

    The peridots in the gem collection of our Museum were acquired a long time ago (part of them were from the collection of King William I of the Netherlands). We should be sceptical about data on the origin of this material. Firstly we do not generally know whether the stones were bought or received

  3. Some unusual gemstones in the collection of the Rijksmuseum van Geologie en Mineralogie of Leiden

    NARCIS (Netherlands)

    Zwaan, P.C.

    1955-01-01

    Our Museum can take pride in a very valuable gem collection for, besides the numerous specimens which were gathered by King William I of the Netherlands a great many of the more unusual stones are to be found in it. Especially since World War II the Museum has acquired many interesting and important

  4. Reference values for anxiety questionnaires: the Leiden Routine Outcome Monitoring Study.

    Science.gov (United States)

    Schulte-van Maaren, Yvonne W M; Giltay, Erik J; van Hemert, Albert M; Zitman, Frans G; de Waal, Margot W M; Carlier, Ingrid V E

    2013-09-25

    The monitoring of patients with an anxiety disorder can benefit from Routine Outcome Monitoring (ROM). As anxiety disorders differ in phenomenology, several anxiety questionnaires are included in ROM: Brief Scale for Anxiety (BSA), PADUA Inventory Revised (PI-R), Panic Appraisal Inventory (PAI), Penn State Worry Questionnaire (PSWQ), Worry Domains Questionnaire (WDQ), Social Interaction, Anxiety Scale (SIAS), Social Phobia Scale (SPS), and the Impact of Event Scale-Revised (IES-R). We aimed to generate reference values for both 'healthy' and 'clinically anxious' populations for these anxiety questionnaires. We included 1295 subjects from the general population (ROM reference-group) and 5066 psychiatric outpatients diagnosed with a specific anxiety disorder (ROM patient-group). The MINI was used as diagnostic device in both the ROM reference group and the ROM patient group. To define limits for one-sided reference intervals (95th percentile; P95) the outermost 5% of observations were used. Receiver Operating Characteristics (ROC) analyses were used to yield alternative cut-off values for the anxiety questionnaires. For the ROM reference-group the mean age was 40.3 years (SD=12.6), and for the ROM patient-group it was 36.5 years (SD=11.9). Females constituted 62.8% of the reference-group and 64.4% of the patient-group. P95 ROM reference group cut-off values for reference versus clinically anxious populations were 11 for the BSA, 43 for the PI-R, 37 for the PAI Anticipated Panic, 47 for the PAI Perceived Consequences, 65 for the PAI Perceived Self-efficacy, 66 for the PSWQ, 74 for the WDQ, 32 for the SIAS, 19 for the SPS, and 36 for IES-R. ROC analyses yielded slightly lower reference values. The discriminative power of all eight anxiety questionnaires was very high. Substantial non-response and limited generalizability. For eight anxiety questionnaires a comprehensive set of reference values was provided. Reference values were generally higher in women than in men, implying the use of gender-specific cut-off values. Each instrument can be offered to every patient with MAS disorders to make responsible decisions about continuing, changing or terminating therapy. © 2013 Elsevier B.V. All rights reserved.

  5. Handgrip strength at midlife and familial longevity : The Leiden Longevity Study

    NARCIS (Netherlands)

    Ling, Carolina H.Y.; De Craen, Anton J.M.; Eline Slagboom, P.; Westendorp, Rudi G.J.; Maier, Andrea B.

    2012-01-01

    Low handgrip strength has been linked with premature mortality in diverse samples of middle-aged and elderly subjects. The value of handgrip strength as marker of "exceptional" human longevity has not been previously explored. We postulated that the genetic influence on extreme survival might also

  6. Identification of prognostic and diagnostic biomarkers of glucose intolerance in ApoE3Leiden mice

    NARCIS (Netherlands)

    Wopereis, S.; Radonjic, M.; Rubingh, C.; Erk, M. van; Smilde, A.; Duyvenvoorde, W. van; Cnubben, N.; Kooistra, T.; Ommen, B. van; Kleemann, R.

    2012-01-01

    The prevalence of diabetes mellitus Type 2 could be significantly reduced by early identification of subjects at risk, allowing for better prevention and earlier treatment. Glucose intolerance (GI) is a hallmark of the prediabetic stage. This study aims at identifying 1) prognostic biomarkers

  7. [Prevalence of chronic fatigue syndrome in 4 family practices in Leiden].

    Science.gov (United States)

    Versluis, R G; de Waal, M W; Opmeer, C; Petri, H; Springer, M P

    1997-08-02

    To determine the prevalence of chronic fatigue syndrome (CFS) in general practice. Descriptive. General practice and primary health care centres in Leyden region, the Netherlands. RNUH-LEO is a computerized database which contains the anonymous patient information of one general practice (with two practitioners) and four primary health care centres. The fourteen participating general practitioners were asked what International Classification of Primary Care (ICPC) code they used to indicate a patient with chronic fatigue or with CFS. With these codes and with the code for depression patients were selected from the database. It then was determined whether these patients met the criteria of CFS by Holmes et al. The general practitioners used 10 codes. Including the code for depression a total of 601 patients were preselected from a total of 23,000 patients in the database. Based on the information from the patients' records in the database, 42 of the preselected patients were selected who might fulfill the Holmes' criteria of CFS. According to the patients' own general practitioner, 25 of the 42 patients would fulfil the Holmes' criteria. The men:women ratio was 1:5. The prevalence of CFS in the population surveyed was estimated to be at least 1.1 per 1,000 patients.

  8. A life of learning in Leiden. The mathematician Frans van Schooten (1615-1660)

    NARCIS (Netherlands)

    Dopper, J.G.

    2014-01-01

    Frans van Schooten jr. (1615-1660) was one of the most influential Dutch mathematicians of the seventeenth century. He is best known for his two Latin editions (1649, 1659-61) of the Géométrie (1637) of Descartes, which originally appeared in French as an appendix to the Discours de la Methode. This

  9. Reference values for generic instruments used in routine outcome monitoring: the leiden routine outcome monitoring study

    Directory of Open Access Journals (Sweden)

    Schulte-van Maaren Yvonne WM

    2012-11-01

    Full Text Available Abstract Introduction The Brief Symptom Inventory (BSI, Mood & Anxiety Symptom Questionnaire −30 (MASQ-D30, Short Form Health Survey 36 (SF-36, and Dimensional Assessment of Personality Pathology-Short Form (DAPP-SF are generic instruments that can be used in Routine Outcome Monitoring (ROM of patients with common mental disorders. We aimed to generate reference values usually encountered in 'healthy' and ‘psychiatrically ill’ populations to facilitate correct interpretation of ROM results. Methods We included the following specific reference populations: 1294 subjects from the general population (ROM reference group recruited through general practitioners, and 5269 psychiatric outpatients diagnosed with mood, anxiety, or somatoform (MAS disorders (ROM patient group. The outermost 5% of observations were used to define limits for one-sided reference intervals (95th percentiles for BSI, MASQ-D30 and DAPP-SF, and 5th percentiles for SF-36 subscales. Internal consistency and Receiver Operating Characteristics (ROC analyses were performed. Results Mean age for the ROM reference group was 40.3 years (SD=12.6 and 37.7 years (SD=12.0 for the ROM patient group. The proportion of females was 62.8% and 64.6%, respectively. The mean for cut-off values of healthy individuals was 0.82 for the BSI subscales, 23 for the three MASQ-D30 subscales, 45 for the SF-36 subscales, and 3.1 for the DAPP-SF subscales. Discriminative power of the BSI, MASQ-D30 and SF-36 was good, but it was poor for the DAPP-SF. For all instruments, the internal consistency of the subscales ranged from adequate to excellent. Discussion and conclusion Reference values for the clinical interpretation were provided for the BSI, MASQ-D30, SF-36, and DAPP-SF. Clinical information aided by ROM data may represent the best means to appraise the clinical state of psychiatric outpatients.

  10. The polyporoid types of Junghuhn preserved at Leiden. Letter No. 37

    NARCIS (Netherlands)

    Lloyd, C.G.

    1912-01-01

    JUNGHUHN was among the first to name foreign species of fungi. He made large collections in Java and published a paper that was finely illustrated, in 1839. If all of his types were destroyed many of his species would still live, for he gave good accounts of them and good figures of many of them.

  11. Veiligheid in de verschillende wijzen van transport : samenhang, diversiteit en overdraagbaarheid : lezing symposium "Toekomstig transport, veiligheid voorzien ?", georganiseerd door het Genootschap van Veiligheidswetenschappen en de Vakgroep Veiligheidskunde van de TU Delft, Delft, 21 mei 1991.

    NARCIS (Netherlands)

    Koornstra, M.J.

    1991-01-01

    The analysis of the lack of safety in a transport system depends on the opinion about the conception 'lack of safety' and the possibilities to put the characteristics within this system into operation in a reliable way. Dependent on these conditions, a transport system is considered as a safe one or

  12. First Quantification of Calcium Intake from Calcium-Dense Dairy Products in Dutch Fracture Patients (The Delft Cohort Study

    Directory of Open Access Journals (Sweden)

    Peter van den Berg

    2014-06-01

    Full Text Available Recommendations for daily calcium intake from dairy products are variable and based on local consensus. To investigate whether patients with a recent fracture complied with these recommendations, we quantified the daily dairy calcium intake including milk, milk drinks, pudding, yoghurt, and cheese in a Dutch cohort of fracture patients and compared outcomes with recent data of a healthy U.S. cohort (80% Caucasians. An observational study analyzed dairy calcium intakes of 1526 female and 372 male Dutch fracture patients older than 50. On average, participants reported three dairy servings per day, independently of age, gender or population density. Median calcium intake from dairy was 790 mg/day in females and males. Based on dairy products alone, 11.3% of women and 14.2% of men complied with Dutch recommendations for calcium intake (adults ≤ 70 years: 1100 mg/day and >70 years: 1200 mg/day. After including 450 mg calcium from basic nutrition, compliance raised to 60.5% and 59.1%, respectively, compared to 53.2% in the U.S. cohort. Daily dairy calcium intake is not associated with femoral neck bone mineral density (BMD T-scores or WHO Fracture Assessment Tool (FRAX risk scores for major fracture or hip fracture. However, when sub analyzing the male cohort, these associations were weakly negative. The prevalence of maternal hip fracture was a factor for current fracture risks, both in women and men. While daily dairy calcium intake of Dutch fracture patients was well below the recommended dietary intake, it was comparable to intakes in a healthy U.S. cohort. This questions recommendations for adding more additional dairy products to preserve adult skeletal health, particularly when sufficient additional calcium is derived from adequate non-dairy nutrition.

  13. First Quantification of Calcium Intake from Calcium-Dense Dairy Products in Dutch Fracture Patients (The Delft Cohort Study)

    OpenAIRE

    van den Berg, Peter; van Haard, Paul M. M.; van den Bergh, Joop P. W.; Niesten, Dieu Donné; van der Elst, Maarten; Schweitzer, Dave H.

    2014-01-01

    Recommendations for daily calcium intake from dairy products are variable and based on local consensus. To investigate whether patients with a recent fracture complied with these recommendations, we quantified the daily dairy calcium intake including milk, milk drinks, pudding, yoghurt, and cheese in a Dutch cohort of fracture patients and compared outcomes with recent data of a healthy U.S. cohort (80% Caucasians). An observational study analyzed dairy calcium intakes of 1526 female and 372 ...

  14. First quantification of calcium intake from calcium-dense dairy products in Dutch fracture patients (the Delft cohort study).

    Science.gov (United States)

    van den Berg, Peter; van Haard, Paul M M; van den Bergh, Joop P W; Niesten, Dieu Donné; van der Elst, Maarten; Schweitzer, Dave H

    2014-06-23

    Recommendations for daily calcium intake from dairy products are variable and based on local consensus. To investigate whether patients with a recent fracture complied with these recommendations, we quantified the daily dairy calcium intake including milk, milk drinks, pudding, yoghurt, and cheese in a Dutch cohort of fracture patients and compared outcomes with recent data of a healthy U.S. cohort (80% Caucasians). An observational study analyzed dairy calcium intakes of 1526 female and 372 male Dutch fracture patients older than 50. On average, participants reported three dairy servings per day, independently of age, gender or population density. Median calcium intake from dairy was 790 mg/day in females and males. Based on dairy products alone, 11.3% of women and 14.2% of men complied with Dutch recommendations for calcium intake (adults ≤ 70 years: 1100 mg/day and >70 years: 1200 mg/day). After including 450 mg calcium from basic nutrition, compliance raised to 60.5% and 59.1%, respectively, compared to 53.2% in the U.S. cohort. Daily dairy calcium intake is not associated with femoral neck bone mineral density (BMD) T-scores or WHO Fracture Assessment Tool (FRAX) risk scores for major fracture or hip fracture. However, when sub analyzing the male cohort, these associations were weakly negative. The prevalence of maternal hip fracture was a factor for current fracture risks, both in women and men. While daily dairy calcium intake of Dutch fracture patients was well below the recommended dietary intake, it was comparable to intakes in a healthy U.S. cohort. This questions recommendations for adding more additional dairy products to preserve adult skeletal health, particularly when sufficient additional calcium is derived from adequate non-dairy nutrition.

  15. A study on sedimentation of tidal rivers and channels flowing into deep bay with a Delft3D model

    NARCIS (Netherlands)

    Wang, Z.B.; Tse, M.L.; Lau, S.C.

    2011-01-01

    For supporting Drainage Services Department of the Government of the Hong Kong SAR to develop a comprehensive strategy for overall land drainage and flood control in Yuen Long and North Districts, 3D hydrodynamic and sediment transport model is set up. The model deploys Domain Decomposition

  16. Exploring the acceptable travel time concept in the US and European contexts. Results from Berkeley, CA and Delft, The Netherlands

    NARCIS (Netherlands)

    Milakis, D.; van Wee, G.P.

    2016-01-01

    “Do people consider an acceptable travel time?” We raised this question in Milakis, Cervero, and van Wee (2015) to explore the validity of the acceptable travel time concept as a possible factor in the travel and destination decision-making process. Results from interviews with 20 subjects in

  17. Teaching nanoscience across scientific and geographical borders - A European Master programme in nanoscience and nanotechnology

    International Nuclear Information System (INIS)

    Chesneau, A; Schwille, P; Groeseneken, G; Heremans, P; Rep, D; Rudquist, P; Wendin, G; Sluijter, B

    2008-01-01

    Within the Erasmus Mundus Master (EMM) Programme, five European Universities (KU Leuven, Belgium, Chalmers University of Technology, Sweden, Delft University of Technology and Leiden University, the Netherlands, and the University of Dresden, Germany) have joined forces to offer a unique master programme in Nanoscience and Nanotechnology, 'EMM-nano', at the cutting edge of state-of-the-art research. The students design and build their individual area of specialisation within nanophysics, nanotechnology, biophysics, biotechnology through their choice of trajectory between the partners. We discuss some of the challenges related to the crossdisciplinary nature of the field, educational activities in cleanrooms, and issues related to the integration of teaching programmes across the borders within Europe

  18. Construction, jobs and affordable energy in the north of the Netherlands; Bouwen, Banen en Betaalbare energie in Noord-Nederland

    Energy Technology Data Exchange (ETDEWEB)

    Blom, M.; Schepers, B. [CE Delft, Delft (Netherlands); Tieben, B. [SEO Economic Research, Amsterdam (Netherlands)

    2013-03-15

    Additional investments to boost the energy efficiency of the housing stock in the north of the Netherlands can create a substantial number of new jobs in construction and supply industries. That is the conclusion of a pilot study carried out by CE Delft and SEO Economic Research. Depending on the energy efficiency target adopted, an annual investment of around euro 400 million would lead to some 4,500 new jobs (in the first year). This would mean over 2,000 unemployed construction workers being able to return to work. To realise these investments requires a 'quantum leap' in funding. For an efficiency improvement scenario of 2% per annum this would mean a quadrupling of present investment plans in this part of the country [Dutch] Extra investeringen in energiebesparing van bestaande woningen kunnen voor Noord-Nederland een fors aantal banen in de bouw en de toeleverende industrie op leveren. Dat is de conclusie uit een verkenning die door CE Delft en SEO Economisch Onderzoek in opdracht van de Natuur en Milieufederatie Drenthe is uitgevoerd. Afhankelijk van de besparingsdoelstelling leiden investeringen van zo'n 400 miljoen per jaar tot zo'n 4.500 extra banen (eerste jaar). Daarmee kunnen ruim 2.000 werkloze bouwvakkers aan het werk worden geholpen. Om deze investeringen te kunnen realiseren, is een forse schaalsprong nodig in het financieringsaanbod. In het scenario van 2%+ per jaar komt dit neer op een verviervoudiging van de huidige investeringsambitie in Noord-Nederland.

  19. Stemcell Information: SKIP000532 [SKIP Stemcell Database[Archive

    Lifescience Database Archive (English)

    Full Text Available yology, Leiden University Medical Center, Leiden, and Interuniversity Cardiology Institute of the Netherland...ty Medical Center, Leiden, and Interuniversity Cardiology Institute of the Netherlands, Utrecht, the Netherl...ands Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, and Interuniversity Cardiology...University Medical Center, Leiden, and Interuniversity Cardiology Institute of th... Embryology, Leiden University Medical Center, Leiden, and Interuniversity Cardiology Institute of the Nethe

  20. Preferential campesterol incorporation into various tissues in apolipoprotein E*3-Leiden mice consuming plant sterols or stanols

    NARCIS (Netherlands)

    Plat, J.; Jong, A.de; Volger, O.L.; Princen, H.M.G.; Mensink, R.P.

    2008-01-01

    Intestinal absorption of plant sterols and stanols is much lower as compared with that of cholesterol; and therefore, serum concentrations are low. Circulating plant sterols and stanols are incorporated into tissues. However, hardly any data are available about tissue distributions of individual

  1. De blinde vlek van de filosofie : Een leven leiden: Over nut en nadeel van de filosofie voor het leven

    NARCIS (Netherlands)

    Boomkens, R.

    2016-01-01

    Age-old philosophical texts, from Plato to Montaigne or from Lao-tse to Rousseau, are still being read by many. What makes these texts so attractive and ‘contemporary’ today, other than scientific texts from long ago? Most of the time these texts do not address empirical or conceptual questions, but

  2. How community innovation works : a material-semiotic analysis of the wireless Leiden Wi-Fi network

    NARCIS (Netherlands)

    Verhaegh, Stefan

    2010-01-01

    Het doel van dit proefschrift is op basis van empirisch onderzoek op het terrein van informatie- en communicatietechnologie een bijdrage te leveren aan theorievorming over innovatiepraktijken door gebruikers. Dat doe ik door innovatie door gebruikers vanuit een materieel-semiotisch perspectief te

  3. Atorvastatin increases HDL cholesterol by reducing CETP expression in cholesterol-fed APOE*3-Leiden.CETP mice

    NARCIS (Netherlands)

    Haan, W. de; Hoogt, C.C. van der; Westerterp, M.; Hoekstra, M.; Dallinga-Thie, G.M.; Princen, H.M.G.; Romijn, J.A.; Jukema, J.W.; Havekes, L.M.; Rensen, P.C.N.

    2008-01-01

    Objective: In addition to lowering low-density lipoprotein (LDL)-cholesterol, statins modestly increase high-density lipoprotein (HDL)-cholesterol in humans and decrease cholesteryl ester transfer protein (CETP) mass and activity. Our aim was to determine whether the increase in HDL depends on CETP

  4. Kwartaire Bovidae van Nederland. De schedels en hoornpitten, welke zich bevinden in het Rijksmuseum van Geologie te Leiden

    NARCIS (Netherlands)

    Vlerk, van der I.M.

    1942-01-01

    The plates I—XI contain illustrations of all the skulls and horn-cores of Bovidae from the Quaternary of the Netherlands, brought together in the National Museum of Geology at Leyden, Holland. They were all photographed with the occiputs vertical or what is thought to be vertical. They are described

  5. Felipe II y la conquista de reliquias por los Tercios de Flandes: el ejemplo de Leiden (1570-1574

    Directory of Open Access Journals (Sweden)

    Ferrer García, Félix A.

    2014-06-01

    Full Text Available The patrimonial principles and the exaggerated religious beliefs of Phillip II of Spain, placed in the complex foreign affairs of the 16th century, led to the presence of the castilian troops in many european battlefields. Phillip II had to cope with a raising international hostility, not only due to strategic reasons but also to his clear imperialist ideas. But we can´t avoid some ideological statements because the King considered himself as the true protector of Christianity. The Spanish Tercios, and specially the Duke of Alba, developed military purposes but they were also finders and guardians of the numerous relics from the northern european territories.La concepción patrimonial y el inflamado ímpetu religioso de Felipe II, en el marco de la compleja política exterior del siglo XVI, provocaron la presencia de las tropas castellanas en numerosos campos de batalla europeos. Durante su gobierno el rey contempló la creciente hostilidad internacional, bien por factores estratégicos, bien por un no disimulado afán imperialista, sin olvidar algunos elementos ideológicos, pues el monarca se consideraba defensor de la cristiandad. Los Tercios de Flandes, con el Gran Duque de Alba, ejercitaron su función militar, pero también actuaron como buscadores, acopiadores y custodios de numerosas reliquias depositadas en los territorios europeos septentrionales.

  6. Effect of discontinuation of antihypertensive medication on orthostatic hypotension in older persons with mild cognitive impairment: the DANTE Study Leiden.

    Science.gov (United States)

    Moonen, Justine E F; Foster-Dingley, Jessica C; de Ruijter, Wouter; van der Grond, Jeroen; de Craen, Anton J M; van der Mast, Roos C

    2016-03-01

    the relationship between antihypertensive medication and orthostatic hypotension in older persons remains ambiguous, due to conflicting observational evidence and lack of data of clinical trials. to assess the effect of discontinuation of antihypertensive medication on orthostatic hypotension in older persons with mild cognitive impairment. a total of 162 participants with orthostatic hypotension were selected from the Discontinuation of Antihypertensive Treatment in Elderly people (DANTE) Study. This randomised clinical trial included community-dwelling participants aged ≥75 years, with mild cognitive impairment, using antihypertensive medication and without serious cardiovascular disease. Participants were randomised to discontinuation or continuation of antihypertensive treatment (ratio 1:1). Orthostatic hypotension was defined as a drop of at least 20 mmHg in systolic blood pressure and/or 10 mmHg in diastolic blood pressure on standing from a seated position. Outcome was the absence of orthostatic hypotension at 4-month follow-up. Relative risks (RR) were calculated by intention-to-treat and per-protocol analyses. at follow-up, according to intention-to-treat analyses, of the 86 persons assigned to discontinuation of antihypertensive medication, 43 (50%) were free from orthostatic hypotension, compared with 29 (38%) of the 76 persons assigned to continuation of medication [RR 1.31 (95% confidence interval (CI) 0.92-1.87); P = 0.13]. Per-protocol analysis showed that recovery from orthostatic hypotension was significantly higher in persons who completely discontinued all antihypertensive medication (61%) compared with the continuation group (38%) [RR 1.60 (95% CI 1.10-2.31); P = 0.01]. in older persons with mild cognitive impairment and orthostatic hypotension receiving antihypertensive medication, discontinuation of antihypertensive medication may increase the probability of recovery from orthostatic hypotension. © The Author 2016. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  7. Key Inflammatory Processes in Human NASH Are Reflected in Ldlr−/−.Leiden Mice: A Translational Gene Profiling Study

    NARCIS (Netherlands)

    Morrison, M.C.; Kleemann, R.; Koppen, A. van; Hanemaaijer, R.; Verschuren, L.

    2018-01-01

    Introduction: It is generally accepted that metabolic inflammation in the liver is an important driver of disease progression in NASH and associated matrix remodeling/fibrosis. However, the exact molecular inflammatory mechanisms are poorly defined in human studies. Investigation of key pathogenic

  8. Effect of Discontinuation of Antihypertensive Treatment in Elderly People on Cognitive Functioning-the DANTE Study Leiden

    DEFF Research Database (Denmark)

    Moonen, Justine E F; Foster-Dingley, Jessica C; de Ruijter, Wouter

    2015-01-01

    whether discontinuation of antihypertensive treatment in older persons with mild cognitive deficits improves cognitive, psychological, and general daily functioning. DESIGN, SETTING, AND PARTICIPANTS: A community-based randomized clinical trial with a blinded outcome assessment at the 16-week follow...... in secondary outcomes, including differences (95% CIs) in change in compound scores of the 3 cognitive domains (executive function, -0.07 [-0.29 to 0.15; P = .52], memory, 0.08 [-0.12 to 0.29; P = .43], and psychomotor speed, -0.85 [-1.72 to 0.02; P = .06]), symptoms of apathy (0.17 [-0.65 to 0.99; P = .68...

  9. Biografische notities betreffende verzamelaars voor het Rijksmuseum van Natuurlijke Historie te Leiden. I. Hendrik Severinus Pel (1818-1876)

    NARCIS (Netherlands)

    Holthuis, L.B.

    1968-01-01

    INHOUD Inleiding (tot de serie)................ Hendrik Severinus Pel (1818-1876)............. 5 I. Leidse tijd (1818-1840).............. 5 II. Verblijf in West Afrika (1840-1855).......... 7 A. Voorgeschiedenis............... 7 B. Chronologisch overzicht van Pel's verblijf in West Afrika .... 10 C.

  10. Pre-adult versus adult onset major depressive disorder in a naturalistic patient sample: the Leiden Routine Outcome Monitoring Study.

    Science.gov (United States)

    van Noorden, M S; Minkenberg, S E; Giltay, E J; den Hollander-Gijsman, M E; van Rood, Y R; van der Wee, N J; Zitman, F G

    2011-07-01

    Pre-adult onset of major depressive disorder (MDD) may predict a more severe phenotype of depression. As data from naturalistic psychiatric specialty care settings are scarce, we examined phenotypic differences between pre-adult and adult onset MDD in a large sample of consecutive out-patients. Altogether, 1552 out-patients, mean age 39.2 ± 11.6 years, were diagnosed with current MDD on the Mini-International Neuropsychiatric Interview Plus diagnostic interview as part of the usual diagnostic procedure. A total of 1105 patients (71.2%) had complete data on all variables of interest. Pre-adult onset of MDD was defined as having experienced the signs and symptoms of a first major depressive episode before the age of 18 years. Patients were stratified according to the age at interview (20-40/40-65 years). Correlates of pre-adult onset were analysed using logistic regression models adjusted for age, age squared and gender. Univariate analyses showed that pre-adult onset of MDD had a distinct set of demographic (e.g. less frequently living alone) and clinical correlates (more co-morbid DSM-IV - Text Revision diagnoses, more social phobia, more suicidality). In the multivariate model, we found an independent association only for a history of suicide attempts [odds ratio (OR) 3.15, 95% confidence intervals (CI) 1.97-5.05] and current suicidal thoughts (OR 1.81, 95% CI 1.26-2.60) in patients with pre-adult versus adult onset MDD. Pre-adult onset of MDD is associated with more suicidality than adult onset MDD. Age of onset of depression is an easy to ascertain characteristic that may help clinicians in weighing suicide risk.

  11. Patient experiences with self-monitoring renal function after renal transplantation: results from a single-center prospective pilot study

    Directory of Open Access Journals (Sweden)

    van Lint CL

    2015-12-01

    Full Text Available Céline L van Lint,1 Paul JM van der Boog,1 Wenxin Wang,2,3 Willem-Paul Brinkman,2 Ton JM Rövekamp,3 Mark A Neerincx,2 Ton J Rabelink,1 Sandra van Dijk1,4 1Department of Nephrology, Leiden University Medical Centre (LUMC, Leiden, 2Faculty of Electrical Engineering, Mathematics and Computer Science, Delft University of Technology, Delft, 3Department of Technology in Healthcare, Prevention and Health, Dutch Organization for Applied Scientific Research (TNO, Leiden, 4Department of Health, Medical and Neuropsychology, Faculty of Social and Behavioural Sciences, Leiden University, Leiden, the Netherlands Background: After a kidney transplantation, patients have to visit the hospital often to monitor for early signs of graft rejection. Self-monitoring of creatinine in addition to blood pressure at home could alleviate the burden of frequent outpatient visits, but only if patients are willing to self-monitor and if they adhere to the self-monitoring measurement regimen. A prospective pilot study was conducted to assess patients’ experiences and satisfaction.Materials and methods: For 3 months after transplantation, 30 patients registered self-measured creatinine and blood pressure values in an online record to which their physician had access to. Patients completed a questionnaire at baseline and follow-up to assess satisfaction, attitude, self-efficacy regarding self-monitoring, worries, and physician support. Adherence was studied by comparing the number of registered with the number of requested measurements.Results: Patients were highly motivated to self-monitor kidney function, and reported high levels of general satisfaction. Level of satisfaction was positively related to perceived support from physicians (P<0.01, level of self-efficacy (P<0.01, and amount of trust in the accuracy of the creatinine meter (P<0.01. The use of both the creatinine and blood pressure meter was considered pleasant and useful, despite the level of trust in the

  12. Study of the performance of three micromixing models in transported scalar PDF simulations of a piloted jet diffusion flame ('Delft Flame III')

    Energy Technology Data Exchange (ETDEWEB)

    Merci, Bart [Department of Flow, Heat and Combustion Mechanics, Ghent University-UGent, B-9000 Ghent (Belgium); Roekaerts, Dirk [Department of Multi-Scale Physics, Delft University of Technology, Delft (Netherlands); Naud, Bertrand [CIEMAT, Madrid (Spain)

    2006-02-01

    Numerical simulation results are presented for a turbulent nonpremixed flame with local extinction and reignition. The transported scalar PDF approach is applied to the turbulence-chemistry interaction. The turbulent flow field is obtained with a nonlinear two-equation turbulence model. A C{sub 1} skeletal scheme is used as the chemistry model. The performance of three micromixing models is compared: the interaction by exchange with the mean model (IEM), the modified Curl's coalescence/dispersion model (CD) and the Euclidean minimum spanning tree model (EMST). With the IEM model, global extinction occurs. With the standard value of model constant C{sub f}=2, the CD model yields a lifted flame, unlike the experiments, while with the EMST model the correct flame shape is obtained. However, the conditional variances of the thermochemical quantities are underestimated with the EMST model, due to a lack of local extinction in the simulations. With the CD model, the flame becomes attached when either the value of C{sub f} is increased to 3 or the pilot flame thermal power is increased by a factor of 1.5. With increased value of C{sub f} better results for mixture fraction variance are obtained with both the CD and the EMST model. Lowering the value of C{sub f} leads to better predictions for mean temperature with EMST, but at the cost of stronger overprediction of mixture fraction variance. These trends are explained as a consequence of variance production by macroscopic inhomogeneity and the specific properties of the micromixing models. Local time stepping is applied so that convergence is obtained more quickly. Iteration averaging reduces statistical error so that the limited number of 50 particles per cell is sufficient to obtain accurate results. (author)

  13. Confidence in and beliefs about first-year engineering student success : Case study from KU Leuven, TU Delft, and TU Graz

    NARCIS (Netherlands)

    de Laet, Tinne; Broos, Tom; van Staalduinen, J.P.; Ebner, Martin; Langie, G.; van Soom, Carolien; Schepers, Wim

    2017-01-01

    This paper explores the confidence starting first-year engineering students have in being successful in the first study year and which study-related behaviour they believe to be important to this end. Additionally, this paper studies which feedback these students would like to receive and compares

  14. HPDC ´12 : proceedings of the 21st ACM symposium on high-performance parallel and distributed computing, June 18-22, 2012, Delft, The Netherlands

    NARCIS (Netherlands)

    Epema, D.H.J.; Kielmann, T.; Ripeanu, M.

    2012-01-01

    Welcome to ACM HPDC 2012! This is the twenty-first year of HPDC and we are pleased to report that our community continues to grow in size, quality and reputation. The program consists of three days packed with presentations on the latest developments in high-performance parallel and distributed

  15. Assessment of the relationship between observed crashes and simulated conflicts at intersections. Master of Science Thesis Delft University of Technology, Department of Civil Engineering.

    NARCIS (Netherlands)

    Marchesini, P.A.

    2009-01-01

    The goal of this M.Sc. thesis project is to investigate a traffic safety indicator calculated on the basis of micro-simulation. This safety indicator, TTC (time-to-collision), is based on the concept of a conflict situation; i.e. two vehicles approaching each other in such a way that if they do not

  16. In_sight : Using Existing Wi-Fi networks to Provide Information on Occupancy and Exploitation of Educational Facilities using at Delft University of Technology

    NARCIS (Netherlands)

    van der Spek, S.C.; Verbree, E.; Meijers, B.M.; Bot, F.J.; Braaksma, H.H.; Braggaar, R.C.; Ligtvoet, B.R.; Staats, B.R.; Gartner, G.; Huang, H.

    2016-01-01

    The distribution of people in buildings, the occupancy of lecture-, work- and study places and the accessibility of facilities are essential information at university campuses who have to cope with limited and even shrinking budgets and huge, rising real estate costs. Only little insight is gained

  17. Post-war public housing in trouble : Papers presented at the Congress 'Post-war Public Housing in trouble', Delft, the Netherlands, October 4-5, 1984

    NARCIS (Netherlands)

    Prak, N.L.; Priemus, H.

    1985-01-01

    In a number of countries the social housing sector was given serious food for thought when some relatively new housing estates had to be demolished: Pruitt Igoe (St. Louis), Quarry Hills (Leeds), la Démocratie (Lyon), Linnaeusstraat (Leeuwarden, NL). The management of many other estates proves to be

  18. Konference o srovnávacím výzkumu bydlení, Delft, Nizozemsko, 24.3. – 25.3. 2010

    Czech Academy of Sciences Publication Activity Database

    Sládek, Jan

    2010-01-01

    Roč. 8, č. 5 (2010), s. 9 ISSN 1214-1720 R&D Projects: GA ČR GA403/09/1915 Institutional research plan: CEZ:AV0Z70280505 Keywords : methodology * city * theory Subject RIV: AO - Sociology, Demography http://www.socioweb.cz/upl/editorial/download/179_soc.web._05-2010%20final!.pdf

  19. Heavy metal pollution and sediment transport in the rhinemeuse estuary, using a 2D model Delft3D : Water quality and calamities. Case study Biesbosch

    NARCIS (Netherlands)

    Jose Alonso, J.J.

    2010-01-01

    Different measures will be executed in the framework PKB “Room for the River” in order to lower the water levels in the river area during normative high discharges. The plan Ontpoldering Noordwaard is one of them and has as aim to inundate parts of the Noordwaard during high discharges. Water coming

  20. Exploring the use of automated vehicles as last mile connection of train trips through an agent-based simulation model : An application to Delft, Netherlands

    NARCIS (Netherlands)

    Homem de Almeida Correia, G.

    2017-01-01

    The last mile in a public transport trip is known to bring a large disutility for passengers, because the conventional transport modes for this stage of the trip can, in many cases, be rather slow, inflexible and not provide a seamless experience to passengers. Fully automated vehicles (AVs), that

  1. Ventilation of ETA3-spaces in buildings. Part 1. Design and realization of a smoking area for the Faculty of Architecture in the Delft University of Technology; Ventilatie van ETA3-ruimten in gebouwen. Deel 1. Ontwerp en realisatie van een rookserre voor de faculteit Bouwkunde van de TU Delft

    Energy Technology Data Exchange (ETDEWEB)

    Bronsema, B. [Faculteit Bouwkinde, Technische Universiteit Delft, Delft (Netherlands); Marra, J. [Philips Research, Eindhoven (Netherlands)

    2006-10-15

    The European standard prEN 13779 (CEN 2004) distinguishes four classes of interior spaces in buildings focusing on air quality. The classes are named ETA1 to ETA4. Class ETA3 concerns spaces with a high level of air pollution due to emissions of water vapour, industrial process emissions, chemical pollutants, etc., which substantially impair the air quality. The examples given include toilets, washrooms, kitchens, some chemical laboratories, print shops and specially designed smoking rooms. Hot restaurant kitchens and certain workshops may also be considered to belong to this class. Class ETA4 relates to spaces with an extremely high level of air pollution due to gaseous and other air pollutants which present health hazards. [Dutch] De Europese norm prEN 13779 (CEN 2004) onderscheidt voor verschillende ruimten in gebouwen vier klassen van afnemende luchtkwaliteit, ETA1 t/m ETA4. Klasse ETA3 staat voor ruimten met een hoge graad van luchtverontreiniging door emissie van vocht, processen, chemische verontreinigingen e.d., die de luchtkwaliteit substantieel verminderen. AIs voorbeelden worden genoemd toilet- en wasruimten, keukens, sommige chemische laboratoria, reproruimten, en speciaal ontworpen rookruimten. Ook warme restaurants en sommige werkplaatsen zouden tot deze klasse kunnen worden gerekend. Klasse ETA4 staat voor ruimten met een zeer hoge graad van luchlverontreiniging door geuren en verontreinigingen die schadelijk voor de gezondheid kunnen zijn.

  2. Ventilation of ETA3-spaces in buildings. Part 2. Performance measurements of a smoking area for the Faculty of Architecture in the Delft University of Technology; Ventilatie van ETA3-ruimten in gebouwen. Deel 2. Prestatiemetingen van een rookserre voor de faculteit Bouwkunde van de TU Delft

    Energy Technology Data Exchange (ETDEWEB)

    Bronsema, B. [Faculteit Bouwkinde, Technische Universiteit Delft, Delft (Netherlands); Marra, J. [Philips Research, Eindhoven (Netherlands)

    2006-10-15

    The European standard prEN 13779 (CEN 2004) distinguishes four classes of interior spaces in buildings focusing on air quality. The classes are named ETA1 to ETA4. Class ETA3 concerns spaces with a high level of air pollution due to emissions of water vapour, industrial process emissions, chemical pollutants, etc., which substantially impair the air quality. Part 2 considers the measurement of separation effectiveness and discusses measuring methods using particle sensors. The concept of TRIO concentration mentioned in part 1 is important in this connection. TRIO is a Dutch acronym meaning Environmental Tobacco Smoke, which serves as a criterion for separation effectiveness and ventilation effectiveness. The article then goes on to discuss the theory behind particle sensors, the measurement methods and the measurement results. Finally, the environmental tobacco smoke concentrations are assessed and related to particulate concentrations in reference situations. [Dutch] De Europese norm prEN 13779 (CEN 2004) onderscheidt voor verschillende ruimten in gebouwen vier klassen van afnemende luchtkwaliteit, ETA1 t/m ETA4. Klasse ETA3 staat voor ruimten met een hoge graad van luchtverontreiniging door emissie van vocht, processen, chemische verontreinigingen e.d., die de luchtkwaliteit substantieel verminderen. AIs voorbeelden worden genoemd toilet- en wasruimten, keukens, sommige chemische laboratoria, reproruimten, en speciaal ontworpen rookruimten. Ook warme restaurants en sommige werkplaatsen zouden tot deze klasse kunnen worden gerekend. Klasse ETA4 staat voor ruimten met een zeer hoge graad van luchlverontreiniging door geuren en verontreinigingen die schadelijk voor de gezondheid kunnen zijn. In dit deel 2 wordt de scheidingseffectiviteit in de praktijk gemeten en wordt ingegaan op meetmethodes met behulp van partikelsensoren. Belangrijk hierbij is het begrip TRIO concentratie dat in deel 1 is benoemd. TRIO staat voor TabaksRook In de Omgeving en wordt gebruikt als maatstaf voor de scheidingseffectiviteit en de ventilatie-effectiviteit. Achtereenvolgens wordt ingegaan op de theorie achter partikelsensoren, de meetmethodiek en meetresultaten, en ten slotte worden de TRIO concentraties beoordeeld en gerelateerd aan stofconcentraties in referentiesituaties.

  3. A quick scan of economic value of offshore wind versus biomass co-combustion; Quick scan economische waarde van wind op zee versus biomassabijstook

    Energy Technology Data Exchange (ETDEWEB)

    Rooijers, F.J.; Bennink, D.; Blom, M.J.

    2013-05-15

    Co-combustion of biomass in conventional power stations is currently cheaper than offshore wind power. By the year 2025, though, both forms of renewable energy are expected to be similarly priced. Because offshore wind yields more added value for the Dutch economy and employment than biomass cocombustion, it would seem more logical to earmark more of the funds under the SDE (Dutch renewable energy subsidy scheme) for the former. At the request of the Netherlands Society for Nature and Environment (Natuur en Milieu) CE Delft compared the two generating options to assess how the Netherlands can boost use of renewable energy in the economically wisest manner in the years ahead. This issue is also to be discussed in upcoming consultations under the umbrella of the Netherlands Social and Economic Council (SER), where a new national energy agreement is to be hammered out [Dutch] Biomassabijstook is op dit moment goedkoper dan wind op zee. De verwachting is echter dat tegen 2025 de prijs van beide vormen van hernieuwbare energie vergelijkbaar kunnen zijn. Doordat de toegevoegde waarde voor de Nederlandse economie en werkgelegenheid van wind op zee groter is dan van biomassabijstook, lijkt het logischer dat uit de SDE-gelden meer wind op zee dan biomassa bijstook wordt betaald. Voor Natuur en Milieu heeft CE Delft een vergelijking gemaakt tussen deze twee technieken om de vraag te beantwoorden op welke economisch verstandige manier Nederland de komende jaren het gebruik van hernieuwbare energie kan realiseren. Die vraag is ook aan de orde in het SER-overleg dat de komende maand moet leiden tot een Energieakkoord.

  4. Sensitive Dual Color in vivo Bioluminescence Imaging Using a New Red Codon Optimized Firefly Luciferase and a Green Click Beetle Luciferase

    Science.gov (United States)

    2011-04-01

    Bologna, Italy, 2 Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands, 3 Department of...and approved by the Bioethics Committee of Leiden University, The Netherlands (Animal protocol 08158). Allanimals received humane care in compliance

  5. The effect of PPE-induced emphysema and chronic LPS-induced pulmonary inflammation on atherosclerosis development in APOE*3-LEIDEN mice

    NARCIS (Netherlands)

    Khedoe, P.P.S.J.; Wong, M.C.; Wagenaar, G.T.M.; Plomp, J.J.; Eck, M. van; Havekes, L.M.; Rensen, P.C.N.; Hiemstra, P.S.; Berbée, J.F.P.

    2013-01-01

    Background: Chronic obstructive pulmonary disease (COPD) is characterized by pulmonary inflammation, airways obstruction and emphysema, and is a risk factor for cardiovascular disease (CVD). However, the contribution of these individual COPD components to this increased risk is unknown. Therefore,

  6. Kossmann Maarten, The Arabic Influence on Northern Berber, Leiden - Boston, Brill, (collection Studies in Semitic Languages and Linguistics, Vol. 67, 2013, 461 p.

    Directory of Open Access Journals (Sweden)

    Ana Landgrave Ponce

    2014-05-01

    Full Text Available Les études consacrées à l’influence de l’arabe sur les différents parlers berbères sont anciennes et assez nombreuses (Schuchardt, Pellat, Taïfi, Chaker…. La plupart d’entre elles sont très circonscrites (emprunts lexicaux notamment ou ne portent que sur un parler bien déterminé (touareg, tamazight du Moyen-Atlas, kabyle, etc.. Le principal intérêt de l’ouvrage de Maarten Kossmann est d’être une étude d’ensemble de ce phénomène de contact. The Arabic Influence on Northern Berber est une an...

  7. Inhibition of Glycosphingolipid Synthesis Induces a Profound Reduction of Plasma Cholesterol and Inhibits Atherosclerosis Development in APOE*3 Leiden and Low-Density Lipoprotein Receptor-/- Mice

    NARCIS (Netherlands)

    Bietrix, Florence; Lombardo, Elisa; van Roomen, Cindy P. A. A.; Ottenhoff, Roelof; Vos, Mariska; Rensen, Patrick C. N.; Verhoeven, Arthur J.; Aerts, Johannes M.; Groen, Albert K.

    Objective-The iminosugar N-(5'-adamantane-1'-yl-methoxy)-pentyl-1-deoxynoijirimycin (AMP-DNM), an inhibitor of the enzyme glucosylceramide synthase catalyzing glycosphingolipid (GSL) biosynthesis, ameliorates diabetes and reduces liver steatosis in ob/ob mice. Because an accumulation of

  8. The Demise of the Preformed Embryo: Edinburgh, Leiden, and the Physician-Poet Mark Akenside's Contribution to Re-Establishing Epigenetic Embryology.

    Science.gov (United States)

    Dix, Robin

    2014-01-01

    Seventeenth-century advances in microscopy prompted a shift in the dominant theory of human reproduction from one of epigenesis, derived from such ancient authorities as Aristotle, which posited that the mixing of male and female reproductive material generated a being which had not existed before, to one of preformation, whereby embryologists argued that the offspring of an animal already existed in miniature in the reproductive material. This chapter reveals that the poet, Mark Akenside, anticipated the Enlightenment's challenge to the prevailing preformationist orthodoxy when a medical student at Edinburgh in the late 1730s, as evident in his May 1744 thesis entitled De ortu et incremento foetus humani ('On the Origin and Growth of the Human Foetus'). What prompted Akenside to take such a bold step? Faced with a scarcity of biographical sources, Akenside's major poem on The Pleasures of Imagination (1744) suggests how the poet had been thinking about reproductive processes in innovative contexts and that his medical research informed his concept of poetic creation.

  9. Resveratrol protects against atherosclerosis, but does not add to the antiatherogenic effect of atorvastatin, in APOE*3-Leiden.CETP mice

    NARCIS (Netherlands)

    Berbée, Jimmy F. P.; Wong, Man C.; Wang, Yanan; van der Hoorn, José W. A.; Khedoe, Padmini P. S. J.; van Klinken, Jan B.; Mol, Isabel M.; Hiemstra, Pieter S.; Tsikas, Dimitrios; Romijn, Johannes A.; Havekes, Louis M.; Princen, Hans M. G.; Rensen, Patrick C. N.

    2013-01-01

    Resveratrol is a major constituent of traditional Asian medicinal herbs and red wine and is suggested to be a potential antiatherosclerotic drug due to its proposed hypolipidemic, anti-inflammatory and antioxidative properties. The aim of this study was to evaluate whether resveratrol protects

  10. Resveratrol protects against atherosclerosis, but does not add to the antiatherogenic effect of atorvastatin, in APOE * 3-Leiden.CETP mice

    NARCIS (Netherlands)

    Berbée, J.F.P.; Wong, M.C.; Wang, Y.; Hoorn, J.W.A. van der; Khedoe, P.P.S.J.; Klinken, J.B. van; Mol, I.M.; Hiemstra, P.S.; Tsikas, D.; Romijn, J.A.; Havekes, L.M.; Princen, H.M.G.; Rensen, P.C.N.

    2013-01-01

    Resveratrol is a major constituent of traditional Asian medicinal herbs and red wine and is suggested to be a potential antiatherosclerotic drug due to its proposed hypolipidemic, anti-inflammatory and antioxidative properties. The aim of this study was to evaluate whether resveratrol protects

  11. Risk of venous thromboembolism associated with single and combined effects of Factor V Leiden, Prothrombin 20210A and Methylenetethraydrofolate reductase C677T

    DEFF Research Database (Denmark)

    Simone, Benedetto; De Stefano, Valerio; Leoncini, Emanuele

    2013-01-01

    for interaction = 0.036) and of PT20210A in women using oral contraceptives (p-value for interaction = 0.045). In this large pooled analysis, inclusive of large studies like MEGA, no effect was found for C677T MTHFR on VTE; FVL and PT20210A were confirmed to be moderate risk factors. Notably, double carriers...

  12. Mirtoselect, an anthocyanin-rich bilberry extract, attenuates non-alcoholic steatohepatitis and associated fibrosis in ApoE*3Leiden mice

    NARCIS (Netherlands)

    Morrison, Martine C.; Liang, Wen; Mulder, Petra; Verschuren, Lars; Pieterman, Elsbet; Toet, Karin; Heeringa, Peter; Wielinga, Peter Y.; Kooistra, Teake; Kleemann, Robert

    Background & Aims: Anthocyanins may have beneficial effects on lipid metabolism and inflammation and are demonstrated to have hepatoprotective properties in models of restraint-stressand chemically-induced liver damage. However, their potential to protect against non-alcoholic steatohepatitis (NASH)

  13. Aliskiren inhibits atherosclerosis development and improves plaque stability in APOE*3Leiden.CETP transgenic mice with or without treatment with atorvastatin

    NARCIS (Netherlands)

    Kühnast, S.; Hoorn, J.W.A. van der; Hoek, A.M. van den; Havekes, L.M.; Liau, G.; Jukema, J.W.; Princen, H.M.G.

    2012-01-01

    Objective: Aliskiren is the first commercially available, orally active, direct renin inhibitor approved to treat hypertension. The renin-angiotensin system has been shown to be a significant contributor to the development of hypercholesterolemia-induced atherosclerosis. The aim of this study was to

  14. Presymptomatic testing for BRCA1 and BRCA2: how distressing are the pre-test weeks? Rotterdam/Leiden Genetics Working Group

    NARCIS (Netherlands)

    L.N. Lodder; P. Devilee (Peter); M.F. Niermeijer (Martinus); C.J. Cornelisse (Cees); P.G. Frets; R.W. Trijsburg (Wim); E.J. Meijers-Heijboer (Hanne); J.G.M. Klijn (Jan); H.J. Duivenvoorden (Hugo); A. Tibben (Arend); A. Wagner (Anja); C.A. van der Meer

    1999-01-01

    textabstractPresymptomatic DNA testing for autosomal dominant hereditary breast/ovarian cancer (HBOC) became an option after the identification of the BRCA1 and BRCA2 genes in 1994-1995. Healthy female mutation carriers have a high lifetime risk for breast cancer

  15. A fish oil diet does not reverse insulin resistance despite decreased adipose tissue TNF-alpha protein concentration in ApoE-3*Leiden mice

    NARCIS (Netherlands)

    Muurling, Martin; Mensink, Ronald P.; Pijl, Hanno; Romijn, Johannes A.; Havekes, Louis M.; Voshol, Peter J.

    2003-01-01

    Dietary interventions with fish oil have been found to protect against the development of high-fat diet-induced insulin resistance and to decrease the expression of tumor necrosis factor (TNF)-alpha. However, the effect of fish oil administration on preexisting insulin resistance is subject to

  16. Intervention with a caspase-1 inhibitor reduces obesity-associated hyperinsulinemia, non-alcoholic steatohepatitis and hepatic fibrosis in LDLR-/-.Leiden mice

    NARCIS (Netherlands)

    Morrison, M. C.; Mulder, P.; Salic, K.; Verheij, J.; Liang, W.; van Duyvenvoorde, W.; Menke, A.; Kooistra, T.; Kleemann, R.; Wielinga, P. Y.

    BACKGROUND/OBJECTIVES: Non-alcoholic steatohepatitis (NASH) is a serious liver condition, closely associated with obesity and insulin resistance. Recent studies have suggested an important role for inflammasome/caspase-1 in the development of NASH, but the potential therapeutic value of caspase-1

  17. Anastasiadou M., Salonique, 1830-1912. Une ville ottomane à l'âge des Réformes, Leiden, New York, Koln, Brill, 1997.

    Directory of Open Access Journals (Sweden)

    Jean-Luc Arnaud

    2004-12-01

    Full Text Available Directement tiré d'une thèse soutenue à l'école des Hautes études en sciences sociales, sous la direction de G. Veinstein, ce livre traite des mutations de la ville de Thessalonique au cours de la seconde moitié du XIXe siècle, soit durant la période des réformes (tanzimat de l'Empire ottoman. Il constitue un document de référence à la fois sur la question de la mise en oeuvre des tanzimat en milieu urbain (le premier règlement explicitement urbain date de 1848 et aussi, de manière plus gén...

  18. Perfluoroalkyl sulfonates cause alkyl chain length-dependent hepatic steatosis and hypolipidemia mainly by impairing lipoprotein production in APOE*3-leiden CETP mice

    NARCIS (Netherlands)

    Bijland, S.; Rensen, P.C.N.; Pieterman, E.J.; Maas, A.C.E.; Hoorn, J.W. van der; Erk, M.J. van; Havekes, L.M.; Dijk, K.W. van; Chang, S.C.; Ehresman, D.J.; Butenhoff, J.L.; Princen, H.M.G.

    2011-01-01

    Perfluorobutane sulfonate (PFBS), perfluorohexane sulfonate (PFHxS), and perfluorooctane sulfonate (PFOS) are stable perfluoroalkyl sulfonate (PFAS) surfactants, and PFHxS and PFOS are frequently detected in human biomonitoring studies. Some epidemiological studies have shown modest positive

  19. Thirty Years of Pancreas Transplantation at Leiden University Medical Center : Long-Term Follow-Up in a Large Eurotransplant Center

    NARCIS (Netherlands)

    Kopp, Wouter H; Verhagen, Merel J J; Blok, Joris J; Huurman, Volkert A L; de Fijter, Johan W; de Koning, Eelco J; Putter, Hein; Baranski, Andzrej G; Schaapherder, Alexander F M; Braat, Andries E; Ringers, Jan

    2015-01-01

    BACKGROUND: An overview of 30 years of pancreas transplantation at a high volume center. Analysis of patient survival- and graft survival-associated risk factors. METHODS: All pancreas transplantations performed in our center from January 1, 1984, till December 31, 2012, were evaluated. Covariates

  20. Effects of up to 15 years of recombinant human GH (rhGH) replacement on bone metabolism in adults with growth hormone deficiency (GHD): the Leiden Cohort Study.

    Science.gov (United States)

    Appelman-Dijkstra, Natasha M; Claessen, Kim M J A; Hamdy, Neveen A T; Pereira, Alberto M; Biermasz, Nienke R

    2014-11-01

    Growth hormone deficiency (GHD) in adulthood may be associated with a decreased bone mineral density (BMD), a decreased bone mineral content (BMC) and an increased fracture risk. Recombinant human GH (rhGH) replacement induces a progressive increase in BMD for up to 5-7 years of treatment. Data on longer follow-up are, however, scarce. Two hundred and thirty-adult GHD patients (mean age 47·1 years, 52·6% female), of whom 88% patients had adult-onset (AO) GHD, receiving rhGH replacement for ≥5 years were included in the study. Most patients had multiple pituitary hormone deficiencies. Bone turnover markers, BMC and BMD and T-scores at the lumbar spine and femoral neck were evaluated at baseline, and after 5, 10 and 15 years of rhGH replacement. In addition, clinical fracture incidence was assessed. Mean lumbar spine BMD, lumbar spine BMC and T-scores gradually increased during the first 10 years of rhGH replacement and remained stable thereafter. Largest effects of rhGH supplementation were found in men. In the small subset of patients using bisphosphonates, use of bisphosphonates did not impact additional beneficial effects in the long term. Low baseline BMD positively affected the change in BMD and BMC over time, but there was a negative effect of high GH dose at 1 year on the change in BMD and BMC over time. Clinical fracture incidence during long-term rhGH replacement was 20.1/1000 py. Fifteen years of rhGH replacement in GHD adults resulted in a sustained increase in BMD values at the lumbar spine, particularly in men, and stabilization of BMD values at the femoral neck. Clinical fracture incidence was suggested not to be increased during long-term rhGH replacement. © 2014 John Wiley & Sons Ltd.

  1. Diepgaand-onderzoek verkeersongevallen (DOVO) : bijdrage aan een methodologische verkenning. SWOV-bijdrage aan "Diepgaand onderzoek van verkeersongevallen : ontwerp van een onderzoeksprotocoll", Werkgroep DOVO in opdracht van de Raad voor Verkeersveiligheid, Technische Hogeschool Delft, 1984.

    NARCIS (Netherlands)

    Oppe, S.

    1984-01-01

    When a severe traffic accident occurs, in which many vehicles are involved and many persons are killed or severely injured, when it can be called a disaster which shocks society, there should be a thorough investigation of the accident. The whole accident process, not just the outcome must be

  2. Are you in Control? : That was the key question discussed at the second Dutch Second Dutch Process Control Security Event at the Technical University of Delft, December 4, 2008

    NARCIS (Netherlands)

    Luiijf, H.A.M.

    2009-01-01

    The second Dutch Process Control Security Event attracted many process control people. The event was organised by the National Infrastructure against Cybercrime (NICC). Over hundred people responsible for the security of process control systems (PCS) and related networks in many of the Dutch

  3. Book review: The success of policy analysis studies: an actor perspective, a search for success definitions based on cases in the field of transport and infrastructure in The Netherlands / by Patricia G.J. Twaalfhoven. - Eburon, Delft, 1999

    NARCIS (Netherlands)

    Klok, Pieter J.

    2001-01-01

    This doctoral dissertation is an attempt to formulate a theory on how different actors define the success of a policy analysis study and on the factors that underlie the various definitions of success. The choice for an actor perspective is motivated by the fact that many actors play different roles

  4. Green chemical feedstocks. Potential in the EU and sustainability aspects. Support for the Biofeedstocks Sub-commission of the Corbey Commission; Groene chemische grondstoffen, potentieel in de EU en duurzaamheidsaspecten. Ondersteuning van de Subcommissie Biochemie van de Commissie Corbey

    Energy Technology Data Exchange (ETDEWEB)

    Croezen, H.; Bergsma, G.

    2012-09-15

    Besides applications for power generation and as a transport fuel, biomass can also be used as a chemical feedstock. If the chemical industry in Europe were to switch to 25% biofeedstocks, the sector's demand for biomass would approximate or even slightly exceed that of the transport sector. There are a number of options for biomass use in the chemical industry, with varying requirements for specific types of biomass. To a large extent, the raw biomass used by the chemical industry would be roughly equivalent to that currently used for transport biofuels, although certain routes would involve different bio resources. Compared with applications for transport fuels, use of biomass as a chemical feedstock often has greater environmental benefits, at lower cost. It would be very useful to establish sustainability criteria for the use of biomass by the chemical industry, too. Based partly on this study by CE Delft, the Commission for Sustainability Aspects of Biomass (the Corbey Commission) has drawn up an advisory document recommending introduction of sustainability criteria for use of biomass by the chemical industry [Dutch] Biomassa kan gebruikt wordt als bron voor elektriciteit en transportbrandstof maar ook als grondstof voor de chemie. Als de chemie in Europa voor 25% over zou schakelen op biomassa als grondstof dan zou de vraag vanuit deze sector naar vergelijkbaar of nog iets groter worden dan de vraag naar biomassa van de transportsector. Er zijn verschillende manieren om biomassa in te zetten in de chemie. Deze keuzes leiden tot een verschillende vraag naar soorten biomassa. Een groot deel van de grondstoffen voor biochemie komt overeen met grondstoffen voor de biotransportsector. Sommige routes vragen om andere grondstoffen. Vergeleken met biomassa in transport geeft inzet van biomassa in chemie vaak een hoger milieuvoordeel tegen lagere kosten. Het zou heel nuttig zijn om ook voor biomassa die gebruikt wordt door de chemie duurzaamheidscriteria op te

  5. Electrochemical Oxidation and Detection of Sodium Urate in ...

    African Journals Online (AJOL)

    DR. MIKE HORSFALL

    3 Delft University of Technology, 2600 GA Delft, The Netherlands. ABSTRACT: ... both sodium urate and mixture of urate and tartrate as a cumulative response, in alkaline media, the target ..... electrochemical oxygen demand (EOD) using a.

  6. Bible for boats

    NARCIS (Netherlands)

    Keuning, L.; Wassink, J.

    2013-01-01

    After nearly forty years researching yacht hulls in the Delft towing tank, boat expert Dr. Lex Keuning has decided to share his life’s work with yacht builders and researchers. The Delft Systematic Yacht Hull Series is available online.

  7. Perspectieven in de robotica : Overzicht van samenwerkende disciplines

    NARCIS (Netherlands)

    Horne, C.; De Wolf, S.; Abd El Ghany, M.; Dumay, A.

    1986-01-01

    Symposium gehouden op 20 juni 1986 in het gebouw van de afdeling der Elektrotechniek, Technische Hogeschool Delft, georganiseerd door de IEEE Student Branch Delft, in samenwerking met IEEE Benelux Section NERG en KIvI

  8. Judgments of Learning in Collaborative Learning Environments

    NARCIS (Netherlands)

    Helsdingen, Anne

    2010-01-01

    Helsdingen, A. S. (2010, March). Judgments of Learning in Collaborative Learning Environments. Poster presented at the 1st International Air Transport and Operations Symposium (ATOS 2010), Delft, The Netherlands: Delft University of Technology.

  9. Learning content and the creative cloud

    NARCIS (Netherlands)

    Specht, Marcus

    2012-01-01

    Specht, M. (2012, 18 April). Learning content and the creative cloud. Presentation given at the workshop for creative cloud CLICK workshop Faculteit Bouwkunde & Architectuur TU Delft, Delft, The Netherlands.

  10. Architecture of instruction and delight : a socio-historical analysis of World Exhibitions as a didactic phenomenon (1798-1851-1970)

    NARCIS (Netherlands)

    Wesemael, van P.J.V.

    2001-01-01

    Vert. en bew. van het proefschrift Technische Universiteit Delft: Architectuur van instructie en vermaak : een maatschappij-historische analyse van de wereldtentoonstelling als didactisch verschijnsel (1798-1851-1970). - Delft : Publicatiebureau Bouwkunde, Faculteit der Bouwkunde, Technische

  11. Book Reviews

    Directory of Open Access Journals (Sweden)

    Hans Antlöv

    1996-04-01

    Full Text Available - R. Anderson Sutton, Wim van Zanten, Ethnomusicology in the Netherlands: present situation and traces of the past. Leiden: Centre of Non-Western Studies, Leiden University, 1995, ix + 330 pp. [Oideion; The performing arts worldwide 2. Special Issue]., Marjolijn van Roon (eds. - T.E. Behrend, Willem Remmelink, The Chinese War and the collapse of the Javanese state, 1725-1743. Leiden: KITLV Press, 1994, 297 pp. [Verhandelingen 162]. - Erik Brandt, Eric Venbrux, A death in the Tiwi Islands; Conflict, ritual and social life in an Australian Aboriginal Community. Cambridge: Cambridge University Press, 1995, xvii + 269 pp. - Madelon Djajadiningrat-Nieuwenhuis, Tineke Hellwig, In the shadow of change; Images of women in Indonesian literature. Berkeley: University of California, Centers for South and Southeast Asia Studies, 1994, xiii + 259 pp. [Monograph 35]. - M. Estellie Smith, Peter J.M. Nas, Issues in urban development; Case studies from Indonesia. Leiden: Research School CNWS, 1995, 293 pp. [CNWS Publications 33]. - Uta Gärtner, Jan Becka, Historical dictionary of Myanmar. Metuchen, N.J.: Scarecrow Press, xxii + 328 pp. [Asian Historical Dictionaries 15]. - Beatriz van der Goes, H. Slaats, Wilhelm Middendorp over de Karo Batak, 1914-1919. Deel 1. Nijmegen: Katholieke Universiteit, Faculteit der Rechtsgeleerdheid, 1994, xvii + 313 pp. [Reeks Recht en Samenleving 11]., K. Portier (eds. - Stephen C. Headley, Janet Carsten, About the house, Lévi-Strauss and beyond. Cambridge: Cambridge University Press, 1995, xiv + 300 pp., Stephen Hugh-Jones (eds. - Stephen C. Headley, James J. Fox, Inside Austronesian houses; Perspectives on domestic designs for living. Canberra: Department of Anthropology, Research School of Pacific Studies, The Australian National University, 1993, x + 237 pp. - M. Hekker, Helmut Buchholt, Continuity, change and aspirations; Social and cultural life in Minahasa, Indonesia. Singapore: Institute of Southeast Asian Studies, 1994

  12. Johannes Müller, Exile Memories and the Dutch Revolt: The Narrated Diaspora, 1550-1750

    Directory of Open Access Journals (Sweden)

    C.A. (Annemieke Romein

    2017-10-01

    Full Text Available Johannes Müller, Exile Memories and the Dutch Revolt: The Narrated Diaspora, 1550-1750 (Dissertation Leiden University 2014; Leiden/ Boston: Brill. 2016, 254 pp., ISBN 9789004315914.

  13. [Favorable current prognosis after HLA-identical bone marrow transplantation for children with required severe aplastic anemia; evaluation of 30 years of bone marrow transplantation at the Leiden University Medical Center

    NARCIS (Netherlands)

    Steekelenburg, M. van; Weel-Sipman, M.H. van; Zwinderman, A.H.; Hoogerbrugge, P.M.; Vossen, J.M.J.J.; Egeler, R.M.

    2002-01-01

    OBJECTIVE: To evaluate the results of 30 years of allogeneic HLA-identical bone marrow transplantation (BMT) as the treatment for children with acquired severe aplastic anaemia. DESIGN: Retrospective, descriptive. METHOD: Of all patients who underwent an HLA-identical sibling-donor BMT for severe

  14. World-Maps for Finding the Direction and Distance to Mecca. Innovation and Tradition in Islamic Science. Series: Islamic Philosophy, Theology and Science, Text and Studies 36, Leiden (Brill) / London (Furqan Foundation), 1999. (Awarded the world prize for

    OpenAIRE

    Dalen, Benno van

    2010-01-01

    This beautifully executed book with numerous colour photographs deals with two fascinating metal instruments that surfaced in 1989 and 1995 (a third copy was identified too late to be included in the study). Both consist of a world-map centered around Mecca with a rule that enables one to read off the qibla (sacred direction for Muslim prayer) of more than one hundred localities engraved on the map as well as their distance from Mecca. The metalwork is clearly Safavid and can be dated to appr...

  15. Male apoE*3-Leiden.CETP mice on high-fat high-cholesterol diet exhibit a biphasic dyslipidemic response, mimicking the changes in plasma lipids observed through life in men

    NARCIS (Netherlands)

    Paalvast, Yared; Gerding, Albert; Wang, Yanan; Bloks, Vincent W; van Dijk, Theo H; Havinga, Rick; Willems van Dijk, Ko; Rensen, Patrick C N; Bakker, Barbara M; Kuivenhoven, Jan Albert; Groen, Albert K

    2017-01-01

    Physiological adaptations resulting in the development of the metabolic syndrome in man occur over a time span of several decades. This combined with the prohibitive financial cost and ethical concerns to measure key metabolic parameters repeatedly in subjects for the major part of their life span

  16. No associations between self-reported knee joint instability and radiographic features in knee osteoarthritis patients prior to Total Knee Arthroplasty: A cross-sectional analysis of the Longitudinal Leiden Orthopaedics Outcomes of Osteo-Arthritis study (LOAS) data.

    Science.gov (United States)

    Leichtenberg, Claudia S; Meesters, Jorit J L; Kroon, Herman M; Verdegaal, Suzan H M; Tilbury, Claire; Dekker, Joost; Nelissen, Rob G H H; Vliet Vlieland, Thea P M; van der Esch, Martin

    2017-08-01

    To describe the prevalence of self-reported knee joint instability in patients with pre-surgery knee osteoarthritis (OA) and to explore the associations between self-reported knee joint instability and radiological features. A cross-sectional study including patients scheduled for primary Total Knee Arthroplasty (TKA). Self-reported knee instability was examined by questionnaire. Radiological features consisted of osteophyte formation and joint space narrowing (JSN), both scored on a 0 to three scale. Scores >1 are defined as substantial JSN or osteophyte formation. Regression analyses were provided to identify associations of radiological features with self-reported knee joint instability. Two hundred and sixty-five patients (mean age 69years and 170 females) were included. Knee instability was reported by 192 patients (72%). Substantial osteophyte formation was present in 78 patients (41%) reporting and 33 patients (46%) not reporting knee joint instability. Substantial JSN was present in 137 (71%) and 53 patients (73%), respectively. Self-reported knee instability was not associated with JSN (relative to score 0, odds ratios (95% CI) of score 1, 2 and 3 were 0.87 (0.30-2.54), 0.98 (0.38-2.52), 0.68 (0.25-1.86), respectively) or osteophyte formation (relative to score 0, odds ratios (95% CI) of score 1, 2 and 3 were 0.77 (0.36-1.64), 0.69 (0.23-1.45), 0.89 (0.16-4.93), respectively). Stratified analysis for pain, age and BMI showed no associations between self-reported knee joint instability and radiological features. Self-reported knee joint instability is not associated with JSN or osteophyte formation. Copyright © 2017 Elsevier B.V. All rights reserved.

  17. Aurica Nutt: Gott, Geschlecht und Leiden. Die feministische Theologie Elisabeth A. Johnsons im Vergleich mit den Theologien David Tracys und Mary Dalys. Hamburg u.a.: LIT Verlag 2010.

    Directory of Open Access Journals (Sweden)

    Anja Maria Middelbeck-Varwick

    2010-07-01

    Full Text Available Das theologische Nachdenken über die Rede von Gott angesichts der Leidensgeschichte der Welt erfährt durch das Eintragen der Geschlechterperspektive eine Neuausrichtung, die die Vorstellungen des klassischen Theismus durchbricht. Es gilt, angesichts der nicht abschließend zu beantwortenden Theodizeefrage zu einem angemessenen Sprechen von Gott zurückzufinden. Zur Revision des Gottesbildes haben die feministischen Theologien Entscheidendes beigetragen. Anhand dreier theologischer Gotteskonzeptionen, die im deutschsprachigen Raum bisher vergleichsweise wenig rezipiert wurden, wird der Zusammenhang von „Gott, Geschlecht und Leiden“ vergleichend erörtert. Die Untersuchung mündet und bündelt sich im besonderen Bild des „weinenden Gottes“.The insertion of the gender perspective offers a new direction to theological ruminations on the discussion of God in light of the world’s suffering by breaking through classical conceptions of theism. Given that the theodicy question cannot be conclusively answered, it is necessary to return to an appropriate manner of speaking about God. Feminist theologians have contributed to the decisive revision of God’s image. The book comparatively discusses the connection between “God, gender, and suffering” by using three theological conceptions of God, which have received relatively little attention in German-speaking regions. The study culminates and concentrates itself in the specific image of the “weeping God.”

  18. Ruimtelijke transformaties van de steden in het Randstadgebied (12de-20ste eeuw– Een vergelijkende analyse van de stadsplattegronden

    Directory of Open Access Journals (Sweden)

    Kim Anne-Marie Zweerink

    2017-09-01

    Full Text Available In this study, the transformation of the form of nine cities in the Randstad between 1250 and 1940 in relation to changes in infrastructure is central, namely Utrecht, Dordrecht, Leiden, Haarlem, Delft, Gouda, Amsterdam, Rotterdam and The Hague. Within this time span, three periods of great spatial dynamics are identified, namely the period 1240-1450, 1580-1680 and 1870-1940. From the eleventh century, large areas of hitherto inaccessible peatland were reclaimed and made suitable for agriculture and habitation, creating a number of peatland streams. Water became the main vehicle for goods transport. Along the peat streams, small settlements were formed, part of which developed as market centres for the environment. After the establishment of a system of continuous shipping links through the Randstad area in the thirteenth century, Central Holland became an alternative to the goods transport between the trading centres of the moment, namely the German Rhineland, Flanders and the Baltic Sea. Central Holland performed a role as a transit between the trading chains. Some cities transformed from a pre-urban to an urban settlement. The interlocal infrastructure formed the main structure of the cities. In the second phase of urbanization around 1350, cities developed into industrial centres. In this study, this development is referred to as the term spatial maturity. Typical for this period is that at the intersection of long-distance (water ways an urban centre developed with a port and public buildings. The street pattern was oriented on this centre. The cities showed a remarkable resemblance to size and spatial thematic. Location for economic functions was found in particular by using existing structures. Harbors were made in inland waterways, markets were held on quays, bridges and streets. The main spatial themes in this period are the development of ports, the development of the street pattern, the extensions and the emergence of an urban centre

  19. Book Reviews

    Directory of Open Access Journals (Sweden)

    Redactie KITLV

    1994-07-01

    . Cambridge: Cambridge University Press, 1993. xxii + 322 pp. -Robert Fatton, Jr., Brian Weinstein ,Haiti: The failure of politics. New York: Praeger, 1992. ix + 203 pp., Aaron Segal (eds -Uli Locher, Michel S. Laguerre, The military and society in Haiti. Knoxville: University of Tennessee Press, 1993. x + 223 pp. -Paul E. Brodwin, Leslie G. Desmangles, The faces of the Gods: Vodou and Roman Catholicism in Haiti. Chapel Hill: University of North Carolina Press, 1992. xiii + 218 pp. -Marian Goslinga, Enid Brown, Bibliographical guide to Caribbean mass communication. John A. Lent (comp.. Westport CT: Greenwood Press, 1992. xi + 301 pp.''Suriname and the Netherlands Antilles: An annotated English-language bibliography. Metuchen NJ: Scarecrow Press, 1992. xi + 276 pp. -Jay B. Haviser, F.R. Effert, J.P.B. de Josselin de Jong, curator and archaeologist: A study of his early career (1910-1935. Leiden: Centre of Non-Western studies, University of Leiden, 1992. v + 119 pp. -Hans van Amersfoort, Anil Ramdas, De papegaai, de stier en de klimmende bougainvillea. Essays. Amsterdam: De Bezige Bij, 1992. -Ineke van Wetering, Deonarayan, Curse of the Devtas. Paramaribo: J.J. Buitenweg, 1992. v + 103 pp. -Ineke van Wetering, G. Mungra, Hindoestaanse gezinnen in Nederland. Leiden: Centrum voor Onderzoek Maatschappelijke Tegenstellingen, Rijksuniversiteit Leiden, 1990. 313 pp. -J.M.R. Schrils, Alex Reinders, Politieke geschiedenis van de Nederlandse Antillen en Aruba 1950-1993. Zutphen: Walburg Pers, 1993. 430 pp. -Gert Oostindie, G.J. Cijntje ,Stemmen OK, maar op wie? Delft: Eburon, 1991. 150 pp., A. Nicatia, F. Quirindongo (eds -Genevieve Escure, Donald Winford, Predication in Caribbean English Creoles. Amsterdam & Philadelphia: John Benjamins, 1993, viii + 419 pp. -Jean D'Costa, Lise Winer, Trinidad and Tobago. Amsterdam & Philadelphia: John Benjamins, 1993. xi + 369 pp. (plus cassette

  20. Book Reviews

    Directory of Open Access Journals (Sweden)

    Redactie KITLV

    2002-07-01

    Full Text Available -Martin Baier, Han Knapen, Forests of fortune?; The environmental history of Southeast Borneo, 1600-1880. Leiden: The KITLV Press, 2001, xiv + 487 pp. [Verhandelingen 189] -Jean-Pascal Bassino, Per Ronnas ,Entrepreneurship in Vietnam; Transformations and dynamics. Copenhagen: Nordic Institute of Asian Studies (NIAS and Singapore: Institute of Southeast Asian Studies, 2001, xii + 354 pp., Bhargavi Ramamurty (eds -Adriaan Bedner, Renske Biezeveld, Between individualism and mutual help; Social security and natural resources in a Minangkabau village. Delft: Eburon, 2001, xi + 307 pp. -Linda Rae Bennett, Alison Murray, Pink fits; Sex, subcultures and discourses in the Asia-Pacific. Clayton, Victoria: Monash Asia Institute, 2001, xii + 198 pp. [Monash Papers on Southeast Asia 53.] -Peter Boomgaard, Laurence Monnais-Rousselot, Médecine et colonisation; L'aventure indochinoise 1860-1939. Paris: CNRS Editions, 1999, 489 pp. -Ian Coxhead, Yujiro Hayami ,A rice village saga; Three decades of Green revolution in the Philippines. Houndmills, Basingstoke: MacMillan, 2000, xviii + 274 pp., Masao Kikuchi (eds -Robert Cribb, Frans Hüsken ,Violence and vengeance; Discontent and conflict in New Order Indonesia. Saarbrücken: Verlag für Entwicklungspolitik, 2002, 163 pp. [Nijmegen Studies in Development and Cultural Change 37.], Huub de Jonge (eds -Frank Dhont, Michael Leifer, Asian nationalism. London: Routledge, 2000, x + 210 pp. -David van Duuren, Joseph Fischer ,The folk art of Bali; The narrative tradition. Kuala Lumpur: Oxford University Press, 1998, xx + 116 pp., Thomas Cooper (eds -Cassandra Green, David J. Stuart-Fox, Pura Besakih; Temple, religion and society in Bali. Leiden: KITLV Press, xvii + 470 pp. [Verhandelingen 193.] -Hans Hägerdal, Vladimir I. Braginsky ,Images of Nusantara in Russian literature. Leiden: KITLV Press, 1999, xxvi + 516 pp., Elena M. Diakonova (eds -Hans Hägerdal, David Chandler, A history of Cambodia (third edition. Boulder

  1. A Compact Fluorescence Lifetime Excitation-Emission Spectrometer (FLEXEMS) for Detecting Trace Organics, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — In this Small Business Innovative Research (SBIR) effort, Leiden Measurement Technology (LMT) proposes to design and build the Fluorescence Lifetime Excitation...

  2. A Compact Fluorescence Lifetime Excitation-Emission Spectrometer (FLEXEMS) for Detecting Trace Organics, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — In this Small Business Innovative Research (SBIR) effort, Leiden Measurement Technology (LMT) proposes to design and build the Fluorescence Lifetime Excitation...

  3. Communicatie-architectuur PLC’s en Unity

    NARCIS (Netherlands)

    J.L. Scholte

    2017-01-01

    Voor het afronden van de studie Technische Informatica aan de Haagse Hogeschool te Delft is het noodzakelijk om een afstudeeropdracht uit te voeren. In de loop van zeventien weken is deze opdracht uitgevoerd bij het bedrijf JB Systems te Vlaardingen en Delft door de afstudeerder Jordy Scholte. Dit

  4. Production and Testing of Kiln-cast Glass Components for an Interlocking, Dry-assembled Transparent Bridge

    NARCIS (Netherlands)

    Bristogianni, T.; Oikonomopoulou, F.; Veer, F.A.; Snijder, A.H.; Nijsse, R.

    A pedestrian glass bridge, located at the TU Delft campus site, is being designed by the TU Delft Glass & Transparency Lab. Specifically, the arch-formed bridge consists of cast glass, dry-assembled, interlocking components. To validate the shape of the components, glass mock-ups in 1:2 scale

  5. Delfi?n3Xt Nanosatellite Subsystems : Buying, Outsourcing or Internal Development

    NARCIS (Netherlands)

    Bouwmeester, J.; Hamann, R.J.

    2009-01-01

    This paper provides the results of a study of project management and systems engineering effectiveness regarding the allocation of work and procurement policy of a nanosatellite project. The Delfi-n3Xt nanosatellite is currently under development at Delft University of Technology (TU Delft) and will

  6. What have they done with the MOOCs?! The impact of MOOCs on Campus Education

    NARCIS (Netherlands)

    Barbosa de Almeida Cabral, P.M.; van Valkenburg, W.F.; Dopper, S.M.; Ubachs, George; Konings, Lizzie

    2016-01-01

    In 2013 Delft University of Technology (TU Delft) started to offer Massive Open Online Courses (MOOCs) on the EdX platform. One of the main principles in the MOOC development process was to publish all educational resources under an open license (Creative Commons License) (Ouwehand, 2015). This

  7. Editorial: Driving, cycling and flying : Trends in planning and operational transportation research in Europe

    NARCIS (Netherlands)

    Homem de Almeida Correia, G.; Lopes dos Santos, Bruno F.; Kroesen, M.

    2017-01-01

    In this special issue we present three papers selected from the 18th meeting of the EURO Working Group on Transportation (EWGT) which was held in July 2015 in Delft, the Netherlands, organized by Delft University of Technology. The selected contributions reflect the diversity of topics that were

  8. Windvanger: EWICON wekt energie op zonder rotor

    NARCIS (Netherlands)

    Jaeger, de P.; Balendonck, J.

    2008-01-01

    De Elektrostatische Windenergie Convertor (Ewicon), ontwikkeld door onderzoekers uit Wageningen en Delft, kan wind direct omzetten in elektriciteit, zonder gebruik te maken van bewegende delen. Het rendement van het prototype is echter nog erg laag, zo blijkt uit tests aan de TU Delft. De

  9. Summer Conference on General Topology and Applications (10th) Held in Amsterdam on 15-18 August 1994

    Science.gov (United States)

    1994-08-18

    topology. Joint work by: I. Juhisz and Z. Szentmiid6ssy. Room: KC1.37 Time: TUE 16:40-1 7:00 ABSTRACTS 89 Forcing and Normality, II LUcia R. Junqueira...Gerard A. Venema (Calvin College, Grand Rapids, MI, USA) J. Vermeer (TU Delft, Delft, the Netherlands) Paolo Vitolo (Universita della Basilicata, Potenza

  10. Search for life - VSV symposium 2011; an account of the wonderful symposium organised by the VSV 'Leonardo da Vinci'

    NARCIS (Netherlands)

    Noordam, N.

    2011-01-01

    On March 8th, the Search for Life symposium took place in the TU Delft Auditorium. A day full of new visions on the hunt for extraterrestrial life was programmed. The TU Delft Auditorium provided the perfect playground for the 180 attendants to exchange thoughts on this topic

  11. Project Stratos; reaching space with a student-built rocket

    NARCIS (Netherlands)

    Haneveer, M.

    2013-01-01

    In the spring of 2009 a team of 15 TU Delft students travelled to Kiruna, Sweden with only one goal: to launch the rocket Stratos I they had been working on for 2 years to an altitude of over 12km, thereby claiming the European Amateur Rocket Altitude record. These students were part of Delft

  12. Prêt-à-Loger : Zero-energy home with maximum living quality increase

    NARCIS (Netherlands)

    Van den Dobbelsteen, A.A.J.F.

    2015-01-01

    At the Solar Decathlon Europe 2014 (SDE2014) competition (Versailles, France), the team from the Delft University of Technology (TU Delft) took a stance by not constructing a new-built house but demonstrating the energy renovation of a typical Dutch terraced house. Around a quarter of Dutch housing

  13. C2-C5 hydrocarbon measurements in the Netherlands 1981-1991

    NARCIS (Netherlands)

    Roemer, M.; Builtjes, P.; Esser, P.; Guicherit, R.; Thijsse, T.

    1999-01-01

    Measurements of C2-C5 hydrocarbons on an hourly basis at the TNO site in Delft from 1982 to 1984 and at Moerdijk over the period 1981-1991 are presented. In combination with meteorological data (wind direction and wind speed) the Delft and Moerdijk series are evaluated to identify source categories,

  14. A fundamental study on materials for Li-ion batteries

    NARCIS (Netherlands)

    Verhoeven, V.W.J.

    2001-01-01

    In April 1997 the program "Decentralized Production and Storage for Large-Scale Application of Renewable Energy" of the Delft Interfaculty Research Centre (DIOC) was launched. In this program various groups from several Faculties of the Delft University of Technology studied the feasibility of large

  15. Effect of Short-Crestedness on Wave Loads on Caisson

    DEFF Research Database (Denmark)

    Frigaard, Peter; Helm-Petersen, J.; Christensen, M.

    1995-01-01

    This repor concerns experiments carried out as a combined LIP-MAST-TAW PROJECT DURING May to July, 1994, in the Vinje-Basin at Delft Hydraulics......This repor concerns experiments carried out as a combined LIP-MAST-TAW PROJECT DURING May to July, 1994, in the Vinje-Basin at Delft Hydraulics...

  16. Beyond the photocopy machine revisited : Document delivery in a digital library environment

    NARCIS (Netherlands)

    Delhez, A.N.; De Leeuwe, J.; Dekker, R.

    2005-01-01

    Purpose – To discuss the recent strategic developments of Library at TU Delft. Design/methodology/approach – Developments at TU Delft are contrasted with the five key requirements for document delivery identified in an earlier article in 2001. Findings – That the strategy in most libraries is to

  17. Urbanism on Track : Application of tracking technologies in urbanism

    NARCIS (Netherlands)

    Van der Hoeven, F.D.; Van Schaick, J.; Van der Spek, S.C.; Smit, M.G.J.

    2008-01-01

    Tracking technologies such as GPS, mobile phone tracking, video and RFID monitoring are rapidly becoming part of daily life. Technological progress offers huge possibilities for studying human activity patterns in time and space in new ways. Delft University of Technology (TU Delft) held an

  18. REPORT FROM THE ORGANIZERS: The 25th International Conference on Low Temperature Physics

    Science.gov (United States)

    Kes, Peter

    2009-03-01

    The 25th International Conference on Low Temperature Physics (LT25) was hosted by the Kamerlingh Onnes Laboratorium of the Leiden Institute of Physics and held in the RAI Convention Center in Amsterdam, The Netherlands, 6-13 August 2008. It was the second time that the Kamerlingh Onnes Laboratory had the privilege of organizing an LT conference. In 1958, at LT6, 50 years of liquid helium temperatures were commemorated; in 2008 we celebrated the 100th anniversary of the remarkable achievements of Heike Kamerlingh Onnes and his collaborators in Leiden. In 1958 there were 323 participants and 145 papers appeared in the proceedings; in 2008 these numbers had increased to 1390 participants and 900 papers, of which eventually 849 were accepted. This large participation required adequate conference and housing facilities. These could not be found in Leiden, but were conveniently available in Amsterdam. The triennial International Low Temperature Conferences are organized under the auspices of the International Union of Pure and Applied Physics (IUPAP) through Commission C5 on Low Temperature Physics. It is the most important global meeting that brings together the international scientific community in the broad field of Low Temperature Physics. Because the meeting is held only every third year the 11 plenary and 22 half plenary talks (of 45 or 30 min.) generally provide an overview of important new discoveries over the last few years, whereas the 161 short oral presentations (20 min.) are mainly focused on very recent developments. Since the field is broad, embracing a large section of condensed matter physics, the program is divided into five parallel program lines: A. Quantum Gases, Fluids and Solids B. Superconductivity C. Quantum Phase Transitions and Magnetism D. Electronic Quantum Transport in Condensed Matter E. Cryogenic Techniques and Applications This distinction was used both to group the 1625 accepted abstracts, and the short-oral and poster presentations; the

  19. Report from the organizers Report from the organizers

    Science.gov (United States)

    Kes, Peter

    2009-04-01

    The 25th International Conference on Low Temperature Physics (LT25) was hosted by the Kamerlingh Onnes Laboratorium of the Leiden Institute of Physics and held in the RAI Convention Center in Amsterdam, The Netherlands, 6-13 August 2008. It was the second time that the Kamerlingh Onnes Laboratory had the privilege of organizing an LT conference. In 1958, at LT6, 50 years of liquid helium temperatures were commemorated; in 2008 we celebrated the 100th anniversary of the remarkable achievements of Heike Kamerlingh Onnes and his collaborators in Leiden. In 1958 there were 323 participants and 145 papers appeared in the proceedings; in 2008 these numbers increased to 1390 participants and 900 submitted papers, of which eventually 849 were accepted. This large participation required adequate conference and housing facilities. These could not be found in Leiden, but were conveniently available in Amsterdam. The triennial international low temperature conferences are organized under the auspices of the international union of pure and applied physics (IUPAP) through commission C5 on low temperature physics. It is the most important global meeting that brings together the international scientific community in the broad field of low temperature physics. Because the meeting is held only every third year the 11 plenary and 22 half-plenary talks (of 45 or 30 min) generally provide an overview of important new discoveries over the last few years, whereas the 161 short oral presentations (20 min) are mainly focused on very recent and ongoing developments. Since the field is broad, embracing a large section of condensed matter physics, the program is divided into five parallel program lines: A. Quantum gases, fluids and solids. B. Superconductivity. C. Quantum phase transitions and magnetism. D. Electronic quantum transport in condensed matter. E. Cryogenic techniques and applications. This distinction was used both to group the 1625 accepted abstracts, and the short-oral and

  20. Use of transgenic mice in lipoprotein metabolism and atherosclerosis research

    NARCIS (Netherlands)

    Havekes, L.M.; Vlijmen, B.J.M. van; Jong, M.C.; Dijk, K.W. van; Hofker, M.H.

    1997-01-01

    In APOE*3-Leiden transgenic mice the atherosclerotic lesion size is correlated with plasma cholesterol. In these mice the plasma lipid levels are positively correlated with the relative amount of APOE 3-Leiden protein on the VLDL particle. The plasma cholesterol levels are influenced by diet, age

  1. The Dutch constitution beyond 200 : Tradition and innovation in a multilevel legal order

    NARCIS (Netherlands)

    Franco Ferrari, Giuseppe; Passchier, Reijer; Voermans, W.J.M.

    2018-01-01

    This book covers the updated papers presented at a seminar in Leiden, the Netherlands in November 2016, which was organized by the Italian Public Comparative and European Law Association (DPCE) and the Department of Constitutional and Administrative Law of Leiden University in celebration of the

  2. The Westward Movement of Chinese Export Harbour Views : Significant Paintings with a Social Function

    NARCIS (Netherlands)

    Poel, van der R.H.M.

    2012-01-01

    Article (Chapter) in proceedings of the First Rombouts Graduate Conference Globalization and Glocalization in China, at Leiden University, held in Leiden on 6 and 7 September 2011. This article offers a closer examination of Chinese export harbour views and, in doing so, reveals that waterfronts and

  3. Quiggin's Rank Dependent Model. Review of Generalized Expected Utility Theory: The Rank-Dependent Model, by John Quiggin

    OpenAIRE

    Wakker, Peter

    1994-01-01

    textabstractJohn Quiggin is a professor at the centre for Economic Policy Research of the Australian National University. His research interests are decision making under risk and agricultural economics. The reviewer is an associate professor at the Medical Decision Making Unit, University of Leiden, Leiden, The Netherlands. His main interest is decision making under uncertainty.

  4. Safety and effects of two red blood cell transfusion strategies in pediatric cardiac surgery patients: a randomized controlled trial

    NARCIS (Netherlands)

    de Gast-Bakker, D. H.; de Wilde, R. B. P.; Hazekamp, M. G.; Sojak, V.; Zwaginga, J. J.; Wolterbeek, R.; de Jonge, E.; Gesink-van der Veer, B. J.

    2013-01-01

    To investigate the safety and effects of a restrictive red blood cell (RBC) transfusion strategy in pediatric cardiac surgery patients. Randomized controlled trial. Pediatric ICU in an academic tertiary care center, Leiden University Medical Center, Leiden, The Netherlands. One hundred seven

  5. Prof. Dr. Hilbrand Boschma 22 April 1893 - 22 July 1976 : Obituary and bibliography

    NARCIS (Netherlands)

    Vervoort, W.

    1977-01-01

    Hilbrand Boschma, professor emeritus of systematic zoology and former director of the Rijksmuseum van Natuurlijke Historie (National Museum of Natural History), Leiden, Netherlands, passed away on 22 July, 1976, in Leiden at the age of 83. Born of peasant stock in IJsbrechtum, Wymbritseradeel, in

  6. Erratum to : Daphnia revisited: local stability and bifurcation theory for physiologically structured population models explained by way of an example (Journal of Mathematical Biology, , 61, 2, (277-318), 10.1007/s00285-009-0299-y)

    NARCIS (Netherlands)

    Diekmann, Odo; Gyllenberg, Mats; Metz, J. A.J.; Nakaoka, Shinji; de Roos, André M.

    2017-01-01

    In the original publication, the addresses of the authors Dr. J.A.J. Metz and Dr. S. Nakaoka were incorrectly published. The correct address list for the authors are: J.A.J. Metz: Institute of Biology and Institute of Mathematics, Leiden University, P.O. Box 9516, 2300RA Leiden, The Netherlands. S.

  7. Computational Linguistics in the Netherlands 2004 : Selected papers from the fifteenth CLIN meeting

    NARCIS (Netherlands)

    Wouden, Ton van der; Poß, Michaela; Reckman, Hilke; Cremers, Crit

    2005-01-01

    This volume contains a selection of the papers presented at the fifteenth installment of Computational Linguistics in the Netherlands, held at Leiden University on Friday, December 17th, 2004. Organized by the computational linguists of what was at that time called the Leiden Centre for Linguistics

  8. The Rijksherbarium, in past and present

    NARCIS (Netherlands)

    Kalkman, C.

    1979-01-01

    As is explained in other papers in this jubilee volume (v. Steenis – Kruseman, Smit) it was not on purpose, but by coincidence that the Rijksherbarium came to Leiden. However, Leiden will have been the obvious alternative after Brussels, for Fischer as well as for Von Siebold. There Reinwardt,

  9. Higgs production at next-to-next-to-leading order

    Indian Academy of Sciences (India)

    Instituut-Lorentz, University of Leiden, Leiden, The Netherlands. Abstract. We describe the calculation of inclusive Higgs boson production at hadronic colliders at next-to-next-to-leading order (NNLO) in perturbative quantum chromody- namics. We have used the technique developed in ref. [4]. Our results agree with those.

  10. The emotional impact of genetic testing and aspects of counseling prior to prescription of oral contraceptives.

    Science.gov (United States)

    Gartner, Verena; Weber, Michael; Eichinger, Sabine

    2008-11-01

    Oral contraceptives increase the thrombotic risk in women with factor V Leiden. Emotional aspects of genetic testing prior to the prescription of oral contraceptives (OC), aspects of counseling and referral patterns are widely unknown. Two hundred forty-seven women with and 132 women without factor V Leiden were interviewed by questionnaire. One hundred sixty-one women (65%) with factor V Leiden and 63 (48%) with wild-type factor V responded. One hundred seventy-one women (76%) reported being emotionally disturbed by genetic testing. Eighty percent of women with factor V Leiden and 16% of women with wild-type factor V were discouraged from OC use. Three percent of women with factor V Leiden were encouraged to take OC. Forty-one percent of women with factor V Leiden used at least one hormone contraceptive method after diagnosis. Only 46 women (29%) with factor V Leiden were counseled about the relevance of the mutation in case of pregnancy. Testing for factor V Leiden has considerable emotional impact. Recommendations after testing are not consistently driven by the test result.

  11. Jan Hendrik Oort – A Complete Astronomer (1900 –1992)

    Indian Academy of Sciences (India)

    IAS Admin

    to Leiden to give secret lectures to his loyal students. One of the topics he worked on after joining the Leiden Observatory was to confirm earlier speculations about the rotation of our Galaxy. He analyzed the motions of distant stars and found that our Galaxy rotates differentially, the inner parts moved ahead of the outer parts ...

  12. Report on a collection of Crustacea Decapoda and Stomatopoda from Turkey and the Balkans

    NARCIS (Netherlands)

    Holthuis, L.B.

    1961-01-01

    Under the auspices of Leiden University and with the financial aid of various organisations and institutions, Messrs. E. Hennipman, P. Nijhoff, C. Swennen, A. S. Tulp, W. J. M. Vader, and W. J. J. O. de Wilde, most of whom are biological students of Leiden University, made a collecting trip to

  13. Twintig jaar coeliakie bij kinderen in Nederland: Meer diagnosen en een veranderde verschijningsvorm [Twenty years of childhood coeliac disease in the Netherlands: More diagnoses and changed clinical picture

    NARCIS (Netherlands)

    George, E.K.; Mearin, M.L.; Kanhai, Sh.M.; Franken, H.C.M.; Houwen, R.H.J.; Hirasing, R.A.; Vandenbroucke, J.P.

    1998-01-01

    Objective. To assess the incidence of childhood coeliac disease in the Netherlands and to study the clinical features. Design. Prospective. Setting. Leiden University Medical Centre, Leiden, the Netherlands. Method. Cases of childhood coeliac disease in the Netherlands in 1993-1995 were identified

  14. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    2007-03-26

    Mar 26, 2007 ... Plasticity is a crucial component of the life cycle of invertebrates that live as active ... in terms of resources, or mainly in a dry season that is more stressful. ... Leiden University, PO Box 9516, 2300 RA Leiden, The Netherlands ...

  15. Essay review: Een eeuw op zijn kop

    Directory of Open Access Journals (Sweden)

    Ad Maas

    2015-02-01

    Full Text Available Beschouwing naar aanleiding van de publicatie van (1 Andreas Weber, Hybrid ambitions. Science, governance, and empire (Leiden: Leiden University Press 2012. xi+263 pp., ISBN: 978-90-8728-1663, € 49,95; (2 Martin P.M. Weiss, The masses and the muses. A history of Teylers Museum in the nineteenth century (Dissertatie: Universiteit Leiden 2013. ix+332 pp.; (3 Hieke Huistra, Preparations on the move. The Leiden anatomical collections in the nineteenth century (Dissertatie: Universiteit Leiden 2013. ix+163 pp.; (4 P.A.J. Caljé, Student, universiteit en samenleving. De Groningse universiteit in de negentiende eeuw (Hilversum: Verloren 2009. 631 pp., ISBN: 978-90-6550-978-9, € 49,-.

  16. [Proceedings of the VII international symposium 'Cultural heritage in geosciences, mining and metallurgy : libraries, archives, museums' : "Museums and their collections" held at the Nationaal Natuurhistorisch Museum Leiden (The Netherlands), 19-23 May, 2003 / Cor F. Winkler Prins and Stephen K. Donovan (editors)]: Johann Jacob Scheuchzer (1672-1733) und die Alpenerforschung in der Schweiz - aus den Beständen der Eisenbibliothek

    NARCIS (Netherlands)

    Bouheiry, A.

    2004-01-01

    A short introduction provides some information about the Iron Library, a foundation of Georg Fischer Ltd, at Schaffhausen, which was established in 1949, to enable scientists and students the study of its historic collection, which is mainly concentrated on mining and metals, but includes all other

  17. [Proceedings of the VII international symposium 'Cultural heritage in geosciences, mining and metallurgy : libraries, archives, museums' : "Museums and their collections" held at the Nationaal Natuurhistorisch Museum Leiden (The Netherlands), 19-23 May, 2003 / Cor F. Winkler Prins and Stephen K. Donovan (editors)]: Collections in libraries: a collection of travel-books in the University Library Leoben

    NARCIS (Netherlands)

    Jontes, L.

    2004-01-01

    Collecting seems to be a topic, which has become more and more interesting during the last years. It is not only the passion that seizes people of all parts of our society, it is more than some sort of eccentricity, it goes back to our roots, when we were hunters and gatherers to gain our living.

  18. [Proceedings of the VII international symposium 'Cultural heritage in geosciences, mining and metallurgy : libraries, archives, museums' : "Museums and their collections" held at the Nationaal Natuurhistorisch Museum Leiden (The Netherlands), 19-23 May, 2003 / Cor F. Winkler Prins and Stephen K. Donovan (editors)]: Towards modern petrological collections

    NARCIS (Netherlands)

    Kriegsman, L.M.

    2004-01-01

    Petrological collections result from sampling for academic research, for aesthetic or commercial reasons, and to document natural diversity. Selection criteria for reducing and enhancing collections include adequate documentation, potential for future use, information density, time and money

  19. [Proceedings of the VII international symposium 'Cultural heritage in geosciences, mining and metallurgy : libraries, archives, museums' : "Museums and their collections" held at the Nationaal Natuurhistorisch Museum Leiden (The Netherlands), 19-23 May, 2003 / Cor F. Winkler Prins and Stephen K. Donovan (editors)]: Überlegungen zu einem "Haus der österreichischen (Zeit)Geschichte"

    NARCIS (Netherlands)

    Karner, S.

    2004-01-01

    The installation of a „Haus der Geschichte Österreichs im 20. Jahrhundert" is incorporated in the programme of the Austrian Government, based on a preliminary study by the author. It should be realised in 2006 and will include the history of the Austrian Republic from 1918 to the present,

  20. [Proceedings of the VII international symposium 'Cultural heritage in geosciences, mining and metallurgy : libraries, archives, museums' : "Museums and their collections" held at the Nationaal Natuurhistorisch Museum Leiden (The Netherlands), 19-23 May, 2003 / Cor F. Winkler Prins and Stephen K. Donovan (editors)]: The Alexander the First collection of the Lausanne Museum

    NARCIS (Netherlands)

    Minina, E.L.

    2004-01-01

    Study of written sources in archives sometimes allows to restore the history of collections. A good example is the Alexander the First collection. In 1819, de la Harpe had sent an Etruscan vase to Alexander I as a gift, and had received a collection of Russian minerals in return. Alexander's

  1. [Proceedings of the VII international symposium 'Cultural heritage in geosciences, mining and metallurgy : libraries, archives, museums' : "Museums and their collections" held at the Nationaal Natuurhistorisch Museum Leiden (The Netherlands), 19-23 May, 2003 / Cor F. Winkler Prins and Stephen K. Donovan (editors)]: The 2003 Peter Schmidt award presented to Joanne Lerud

    NARCIS (Netherlands)

    Winkler Prins, C.F.

    2004-01-01

    It was decided 'en petit comite' to present the Peter Schmidt award for 2003 to Joanne Lerud, a dear friend who attended many of the 'Erbe Symposia' and made valuable contributions to them. The award is especially for organising in such an excellent way the Fifth International Symposium 'Cultural

  2. [Proceedings of the VII international symposium 'Cultural heritage in geosciences, mining and metallurgy : libraries, archives, museums' : "Museums and their collections" held at the Nationaal Natuurhistorisch Museum Leiden (The Netherlands), 19-23 May, 2003 / Cor F. Winkler Prins and Stephen K. Donovan (editors)]: Written reports on the effects of mining activities on the natural environment in Idrija in the 19th Century

    NARCIS (Netherlands)

    Car, J.; Dizdarevic, T.

    2004-01-01

    The environmental conditions in the Idrija Mercury Mine and its broader surroundings were strongly affected in the first half of the 19th century by two disastrous pit fires. The fire could only be extinguished by flooding of the pit. The consequences of such flooding was extensive poisoning with

  3. [Proceedings of the VII international symposium 'Cultural heritage in geosciences, mining and metallurgy : libraries, archives, museums' : "Museums and their collections" held at the Nationaal Natuurhistorisch Museum Leiden (The Netherlands), 19-23 May, 2003 / Cor F. Winkler Prins and Stephen K. Donovan (editors)]: How old maps are used to investigate modern environmental issues in the Czech Republic

    NARCIS (Netherlands)

    Cernajsek, T.; Hauser, C.; Posmourny, K.

    2004-01-01

    The Austrian Geological Survey and Czech geological organizations have in their archives source materials that can be used for the landscape restoration. At many places in the Czech Republic, considerable changes of the environment took place due to building and other industrial activities,

  4. [Proceedings of the VII international symposium 'Cultural heritage in geosciences, mining and metallurgy : libraries, archives, museums' : "Museums and their collections" held at the Nationaal Natuurhistorisch Museum Leiden (The Netherlands), 19-23 May, 2003 / Cor F. Winkler Prins and Stephen K. Donovan (editors)]: Landesmuseum Karnten - the Collections of Natural Sciences

    NARCIS (Netherlands)

    Stumfohl, R.

    2004-01-01

    Public museums collections had a hard start in Carinthia: only in 1848 did the first Museum of Natural Sciences open, maintained by the 'Naturhistorischer Verein für Kärnten'. For a long time the collections were based on private donations. In 1884, the 'Naturhistorischer Verein' and the

  5. [Proceedings of the VII international symposium 'Cultural heritage in geosciences, mining and metallurgy : libraries, archives, museums' : "Museums and their collections" held at the Nationaal Natuurhistorisch Museum Leiden (The Netherlands), 19-23 May, 2003 / Cor F. Winkler Prins and Stephen K. Donovan (editors)]: Trautschold's collections in the Vernadsky State Geological Museum of the Russian Academy of Science (Moscow, Russia)

    NARCIS (Netherlands)

    Starodubtseva, I.A.

    2004-01-01

    Hermann (German) Trautschold (1817-1902) is an outstanding researcher of the Carboniferous, Jurassic and Cretaceous geology of central Russia. Three decades (1857-1888) he lived in Moscow and moved from tutor and lecturer of the German language to Professor of Geology of Peter's Agricultural

  6. [Proceedings of the VII international symposium 'Cultural heritage in geosciences, mining and metallurgy : libraries, archives, museums' : "Museums and their collections" held at the Nationaal Natuurhistorisch Museum Leiden (The Netherlands), 19-23 May, 2003 / Cor F. Winkler Prins and Stephen K. Donovan (editors)]: Historical mineral collections in the silver mining town of Kongsberg, Norway

    NARCIS (Netherlands)

    Nordrum, F.S.; Berg, B.I.

    2004-01-01

    The discovery of native silver deposits at Kongsberg, Norway, in 1623 created interest for silver specimens and mineral collecting, also among mining officers. Large collections were donated by J. Hiort, M.T. Brünnich and J. Esmark to the Mining Academy at Kongsberg. The Academy's collections were

  7. [Proceedings of the VII international symposium 'Cultural heritage in geosciences, mining and metallurgy : libraries, archives, museums' : "Museums and their collections" held at the Nationaal Natuurhistorisch Museum Leiden (The Netherlands), 19-23 May, 2003 / Cor F. Winkler Prins and Stephen K. Donovan (editors)]: The distribution of silver specimens from the Kongsberg Silver Mines, Norway, 17th and 18th centuries

    NARCIS (Netherlands)

    Berg, B.I.; Nordrum, F.S.

    2004-01-01

    Specimens of native silver from the Kongsberg mines in Norway are world famous and have been distributed through sales and gifts during the whole period of mining from 1623 to 1958. Names of customers, the number of sold specimens and their silver content are documented in accounts which are

  8. Ultra-fast calculations using diamond

    NARCIS (Netherlands)

    Van Dijk, T.

    2011-01-01

    TU Delft researchers have managed to use a piece of diamond to hold four quantum bits that can be spun, flipped and entangled with each other. This is an important step towards a working quantum computer

  9. FAIR Data; GDPR - Open Data Meeting @ TUD TPM

    OpenAIRE

    Boehmer, Jasmin

    2018-01-01

    Presentation given to academic staff and external researcher at TU Delft Open Data Meeting of Faculty Technology, Policy and Management on 12th March 2018. Topics: Lightweight intro for FAIR data; and the new EU General Data Protection Regulation (GDPR)

  10. Review Article

    African Journals Online (AJOL)

    2012-12-29

    Dec 29, 2012 ... Department of Electrical Engineering, Faculty of Electrical ... proposes several architectures for implementing a rasterizor unit on smart-display, ... Embedded systems ..... Master's thesis, Delft University of Technology.

  11. Prediction of RO/NF membrane rejections of PhACs and organic compounds : A statistical analysis

    NARCIS (Netherlands)

    Yangali-Quintanilla, V.; Kim, T.U.; Kennedy, M.; Amy, G.

    2008-01-01

    OA fund TU Delft Rejections of pharmaceutical compounds (Ibuprofen, Diclofenac, Clofibric acid, Naproxen, Primidone, Phenacetin) and organic compounds (Dichloroacetic acid, Trichloroacetic acid, Chloroform, Bromoform, Trichloroethene, Perchloroethene, Car-bontetrachloride, Carbontetrabromide) by NF

  12. Second International Diagnostic Competition - DXC'10

    Data.gov (United States)

    National Aeronautics and Space Administration — A framework to compare and evaluate diagnosis algorithms (DAs) has been created jointly by NASA Ames Research Center, Palo Alto Research Center, and Delft University...

  13. Marine traffic systems + Supplement

    NARCIS (Netherlands)

    Langeraar, W.; Glansdorp, C.C.

    1976-01-01

    Proceedings of an international symposium organized by Department of Naval Architecture and Maritime Studies of the Delft University of Technology, Liverpool Polytechnic, The Netherlands Maritime Institute, The Royal Institute of Navigation, The University of Wales Institute of Science and

  14. From go-faster stripes to sliding tracksuits

    NARCIS (Netherlands)

    Tigges, J.

    2012-01-01

    Today sports and science go increasingly hand in hand. Together with private companies, sporting bodies and other research centres, TU Delft is involved in many innovative sports-related projects, particularly in water sports, where materials can be crucial.

  15. Ketenregie hard nodig. Siem van Merrienboer (TNO) over slimmere bouwlogistiek

    NARCIS (Netherlands)

    Merrienboer, S.A. van

    2015-01-01

    Er is nog veel te winnen bij de logistieke processen in de bouw met zogenoemde proeftuin bouwprojecten willen diverse partijen samen ervaringen opdoen en vaststellen wat wel en niet werkt. Initiatiefnemers in Tno in Delft

  16. Spectrum Fatigue of 7075-T651 Aluminum Alloy under Overloading and Underloading

    Science.gov (United States)

    2016-03-15

    Ewalds: Report, Delft University of Technology, Dept. of Metallurgy , Delft, The Nethermands, Oct 1978. 14. P. Bristol, and J. A. Roeleveld: in...Proceedings, European Offshore Steels Research Seminar, The Welding Institute, Abbington Hall, Abbington, Cambridge, U. K., 1980, pp. VI/p. 18-1- VI/p. 18... Welding Institute, Abbington Hall, Abbington, Cambridge, U. K., 1980, pp. VI/p. 15-VI/p. 15-15. 16. J. C. Radon, C. M. Branco, and L. E. Culver

  17. Numerical simulation of the hydrodynamic processes in the Red Sea Region

    OpenAIRE

    Madah, Fawaz

    2017-01-01

    The semi-enclosed Red Sea basin presents a unique large marine ecosystem. Therefore it deserves scientific attention. The processes under concern are studied using a combination of very few available observations (water levels and oceanographic data), remotely sensed data as well as numerical modelling approach. The numerical simulations are performed using the three-dimensional modeling system Delft3D, developed by WL | Delft Hydraulics. The first part of the present thesis investigates ...

  18. Building a Green Metropolis. Costs and impacts. Plan of the Dutch environmental organization Milieudefensie; Bouwen aan een Groene Metropool. Kosten en effecten. Plan van Milieudefensie

    Energy Technology Data Exchange (ETDEWEB)

    Doenszelmann, C.E.P.; Schroten, A.

    2011-05-15

    The plan of the Dutch environmental organization Milieudefensie contains various proposals for a more sustainable realization of accessibility in the Rotterdam region. CE Delft mapped the costs and environmental effects of these proposals. [Dutch] In het plan van Milieudefensie worden verschillende voorstellen gedaan om tot een duurzamere invulling van de bereikbaarheid in de Rotterdamse regio te komen. CE Delft heeft de kosten en de milieueffecten van deze voorstellen in beeld gebracht.

  19. Editorial: Driving, cycling and flying: Trends in planning and operational transportation research in Europe

    OpenAIRE

    Homem de Almeida Correia, G.; Lopes dos Santos, Bruno F.; Kroesen, M.

    2017-01-01

    In this special issue we present three papers selected from the 18th meeting of the EURO Working Group on Transportation (EWGT) which was held in July 2015 in Delft, the Netherlands, organized by Delft University of Technology. The selected contributions reflect the diversity of topics that were addressed in this conference, which is dedicated to mathematical modeling of transportation problems. We are happy to have a small but representative sample in which three different modes of transport...

  20. Hybrid computer simulation of the dynamics of the Hoger Onderwijs Reactor

    International Nuclear Information System (INIS)

    Moers, J.C.; Vries, J.W. de.

    1976-01-01

    A distributed parameter model for the dynamics of the Hoger Onderwijs Reactor (HOR) at Delft is presented. The neutronic and the thermodynamic part of this model have been separately implemented on the AD4-IBM1800 Hybrid Computer of the Delft University of Technology Computation Centre. A continuous Space/Discrete Time solution method has been employed. Some test results of the simulation are included

  1. Supporting home based health care in South African rural communities using USSD technology

    CSIR Research Space (South Africa)

    Wouters, B

    2009-08-01

    Full Text Available . The proposed solution was a remote monitoring system, which facilitated transmission of patient information from caregiver to clinic sister. One of the main challenges of the project was to understand the social context of the problem and embodiment... the Dutch University of Technology Delft (TU Delft) and the South African Council for Scientific and Industrial Research (CSIR). The prototype, a USSD application on caregivers’ mobile phones (a sort of ‘interactive SMS’), was mainly used to study users...

  2. New jobs in the building sector. Employment effects of energy conservation in the built environment; Bouwen en banen. Werkgelegenheidseffecten van energiebesparing in de gebouwde omgeving

    Energy Technology Data Exchange (ETDEWEB)

    Volkerink, M.; Rougoor, W.; Tieben, B.; Blom, M.; Schepers, B.

    2012-12-15

    Extra investment in energy efficiency in the existing Dutch housing stock would create a significant number of jobs in construction and upstream supply. Depending on the efficiency targets adopted, annual investments of between euro 2.5 and 4 billion would lead to net additional employment of 67,000 to 110,000 man-years through to 2020. Such a programme would entail improving the energy performance of virtually all Dutch homes and would create new jobs in construction and upstream supply, many segments of which are currently suffering a considerable downturn in demand. Unemployment in the building industry is rising rapidly and presently stands at around 40,000. A 2% per annum improvement in energy efficiency through to 2020 would require a total additional investment of around euro 20 billion. Adopting a more robust target (2%+ p.a.) would entail all privately owned homes being upgraded to energy label C and all rented homes to label B. For this scenario a total additional investment of euro 33 billion would be needed. Over and against these investments stand annual savings on energy bills for Dutch households, amounting to euro 1 billion and euro 1.5 billion respectively in the 2% and 2%+ scenario. Depending on how the scheme is funded, there may be a net monthly windfall for households as a result of such investments in energy efficiency [Dutch] Extra investeringen in energiebesparing bij bestaande gebouwen leveren een fors aantal banen in de bouw en de toeleverende industrie op. Dat is de conclusie uit een studie van SEO Economisch Onderzoek en CE Delft voor het ministerie van Infrastructuur en Milieu. Afhankelijk van de besparingsdoelstelling leiden de investeringen van 2,5 tot 4 miljard euro per jaar tot netto werkgelegenheid van 67.000 tot 110.000 arbeidsjaren tot 2020. Het betekent dat vrijwel alle woningen energetisch verbeterd moeten worden. De investeringen leveren nieuwe werkgelegenheid in de bouw en toeleverende industrie, waar op veel fronten nu

  3. ExoGeoLab Pilot Project for Landers, Rovers and Instruments

    Science.gov (United States)

    Foing, Bernard

    2010-05-01

    )#, S. Direito(6)#, S. Voute (15)#, A. Olmedo-Soler(17)#, T. E. Zegers(1, 15)#, D. Scheer(12)#, K. Bickert(12)#, D. Schildhammer(12)#, B. Jantscher(1, 11, 12)#, MECA Team(6)#, ExoGeoLab ILEWG ExoHab teams(1,4,11) EuroGeoMars team(1,4,5); 1)ESTEC/SRE-S Postbus 299, 2200 AG Noordwijk, NL, 2)NASA Ames , 3)Delft TU , 4)ESTEC TEC Technology Dir., 5)ESTEC HSF Human Spaceflight, 6)VU Amsterdam, 7)ESTEC Education Office, 8)FU Berlin, 9)Max Planck Goettingen, 10)Leiden/GWU , 11)ILEWG ExoHab Team, 12)Austrian Space Forum (OEWF Innsbruck); 14) Ecole de l'Air, Salons de Provence, 15) Utrecht U., 16) MECA Team, 17) Olmedo Knowledge Systems S.L.; * EuroGeoMars Utah crew , # ILEWG Eifel crew, EuroMoonMars/DOMMEX Utah crew.

  4. JTAG boundary-scan of the Belle II pixel vertex detector

    Energy Technology Data Exchange (ETDEWEB)

    Leitl, Philipp [Max-Planck-Institut fuer Physik (Germany); Collaboration: Belle II-Collaboration

    2016-07-01

    For the upgrade of the Vertex Detector at the Belle II experiment, DEPFET sensors will be used. This new technology requires specific electronics for controlling and readout. Therefore three different kinds of Application-Specific Integrated Circuits (ASICs) are mounted very close to the sensors. Because of space limitations ball grid arrays (BGAs) are used for the contacts to the electronic circuitry. After the mounting process this results in a lack of physical access to the electrical connections. With Boundary-Scan tests, following the IEEE Std 1149.1, it is possible to regain access to the pins for interconnection tests. In this way a quality assurance (QA) is possible to verify that the integration was done correctly and that the circuitry and the electronics are working properly. The present user-friendly system is presented, including the description of additionally developed hardware as well as necessary adjustments to the netlist files and Boundary-Scan Description Language (BSDL) Files of the ASICs. Achieved measurement results from the so far produced detector modules are shown.

  5. Climatology of extreme rainfall from rain gauges and weather radar

    NARCIS (Netherlands)

    Overeem, A.

    2009-01-01

    Extreme neerslaggebeurtenissen hebben een grote invloed op de maatschappij en kunnen leiden tot materi¨ele schade en slachtoffers. Daarom is een betrouwbare klimatologie van extreme neerslag belangrijk, bijvoorbeeld voor het ontwerp van afvoersystemen. Een dergelijke klimatologie kan worden

  6. Is this a FAIR data repository?

    OpenAIRE

    Boehmer, Jasmin

    2017-01-01

    Presentation given as part of coaching task for University Leiden LIACS TEAM TASKS INFORMATICS ORIENTATION, on 17th November 2017. Group 3 - FAIR data with Rolf Kleef from International Aid Transparency Initiative (IATI).

  7. Bestrijdingsmiddelen en teelten; een verkenning van de risico's van het gebruik van bestrijdingsmiddelen voor waterorganismen binnen enkele landbouwkundige teelten

    NARCIS (Netherlands)

    Deneer, J.W.

    2003-01-01

    Voor de vijftien landbouwkundige gewassen met het grootste areaal in Nederland is geonventarisseerd tot welke toxische belasting de driftbelasting met bestrijdingsmiddelen zal leiden. Slechts bij twee van de vijftien onderzochte teelten bleeft de belasting van algen, kreeftachtigen en vissen beneden

  8. Opteren voor de Netherlands Commercial Court

    NARCIS (Netherlands)

    Hoeben, J.; Keirse, A.L.M.; Reijneveld, M.D.

    Internationale contracten leiden tot internationale handelsgeschillen. Deze kunnen onder meer worden beslecht bij een commercial court. In Nederland wordt momenteel een Netherlands Commercial Court (NCC) opgericht. Dit introduceert een keuze voor (contracts)partijen voor een nieuw forum voor

  9. Bloedzuigers in pluimveestallen

    NARCIS (Netherlands)

    Mul, M.F.; Mullens, B.A.; Koenraadt, S.

    2010-01-01

    De ornithonyssus sylviarum (noordelijke vogelmijt) vormt in de ons omringende landen een net zo groot probleem als de bloedluis (dermanyssus gallinae). Informatie over deze parasieten moet er toe leiden dat eigenaren van pluimvee ze beter gaan herkennen.

  10. Experiments on chemical and physical evolution of interstellar grain mantles

    International Nuclear Information System (INIS)

    Greenberg, J.M.

    1984-01-01

    The Astrophysical Laboratory at the University of Leiden is the first to succeed in simulating the essential conditions in interstellar space as they affect the evolution of interstellar grains. (author)

  11. Fulltext PDF

    Indian Academy of Sciences (India)

    IAS Admin

    . Leiden: 1927, 1932. Jan Hendrik Oort. Deriving a Unified Equation for Doppler Effect for any. Wave in any Medium from Lorentz Transformations. Kottilil Dileep. 931. 940. Classroom. Face to Face. Leading a Full Life in Two Worlds – Arts and.

  12. Antropoloog esitleb raamatut

    Index Scriptorium Estoniae

    2008-01-01

    Kultuurantropoloog Lorenzo Cañás Bottos esitleb Tallinna Ülikoolis raamatut "Old colony mennonites in Argentina and Bolivia : nation making, religious conflict and imagination of the future" (Leiden ; Boston : Brill, 2008)

  13. Cultivating critical thinking: The effects of instructions on economics students’ reasoning

    NARCIS (Netherlands)

    A.E.G. Heijltjes (Anita)

    2014-01-01

    markdownabstract__Abstract__ Korte, eenvoudig te organiseren instructies leiden al tot betere redeneerprestaties. Dat stelt Anita Heijltjes in haar proefschrift ‘Cultivating Critical Thinking: The Effects of Instructions on Economics Students’ Reasoning’. Heijltjes deed onderzoek naar effectieve

  14. 78 FR 7399 - Application(s) for Duty-Free Entry of Scientific Instruments

    Science.gov (United States)

    2013-02-01

    ... Solenoid Superconducting Magnet. Manufacturer: Leiden Cryogenics, the Netherlands. Intended Use: The...-lived localized states (nitrogen- vacancy centers) and delocalized states (superconducting resonators... the natural tendency of SrTiO 3 to become superconducting to develop superconducting structures with...

  15. NOx emission trade. What is the state-of-the-art?

    International Nuclear Information System (INIS)

    Witkamp, J.

    2003-01-01

    In Leiden, Netherlands, 28 November 2002, a symposium was organized on the subject of NOx emission trade in preparation of a NOx emission trade system. In this article an overview is given of the developments so far [nl

  16. Steviol glycosides in food : Exposure scenarios and health effect assessment

    NARCIS (Netherlands)

    Tijhuis MJ; Wapperom D; Wolterink G; van Oosterhout CHM; Temme EHM; van Klaveren J; Verhagen H; Fransen HP; CVG; vgc

    2011-01-01

    Het gebruik van steviol glycosiden (extracten van de Stevia plant) als zoetstof in voedingsmiddelen is recent goedgekeurd door de Europese Commissie. De marktintroductie van deze producten zal waarschijnlijk niet leiden tot een gezondheidsprobleem in Nederland. Echter, extreme gebruikers van

  17. Verslag uit de jungle is ook jungle van papier : interview door Geertje Dekkers met Andreas Weber en Lambert Schomaker

    NARCIS (Netherlands)

    Weber, Andreas

    2017-01-01

    In de archieven van Naturalis in Leiden ligt een goudmijn te wachten op historici. Maar de 17 duizend pagina's aantekeningen van 19de-eeuwse wetenschappelijke avonturiers vormen een te grote kluif voor menselijke onderzoekers. Beeldherkenning moet uitkomst bieden.

  18. Effect van volledig roostervloer en dichte vloer en doorlaatbaarheid van vloeren in varkensstallen op milieu, diergezondheid en -welzijn en voedselveiligheid: een literatuur review

    NARCIS (Netherlands)

    Vermeij, I.; Enting, J.; Spoolder, H.A.M.

    2009-01-01

    Een integrale benadering kan leiden tot het verbeteren van een vloeruitvoering. Niet alleen spleetbreedte of aandeel roostervloer is belangrijk, maar een minimum percentage doorlaatbaarheid van het totale vloeroppervlak is doorslaggevend

  19. Gebruik van TaqMan PCR voor het kwantificeren van Fusarium spp. en Microdochium nivale in gewassen en gewasresten van tarwe.

    NARCIS (Netherlands)

    Köhl, J.; Haas, de B.H.; Kastelein, P.; Burgers, S.L.G.E.; Waalwijk, C.

    2005-01-01

    Infecties van tarwe door toxigene Fusarium spp. kunnen leiden tot contaminatie van graan met diverse mycotoxines. Voorkoming van mycotoxinebesmetting is uit oogpunt van voedselveiligheid, diergezondheid, maar ook bedrijfseconomisch, vereist. Voor vier Fusariumsoorten is een kwantitatieve detectie

  20. Behavioral Response Research Evaluation Workshop (BRREW)

    Science.gov (United States)

    2015-09-30

    Len Thomas & Catriona Harris Centre for Research into Ecological and Environmental Modelling (CREEM) University of St Andrews St Andrews , UK...Specifically Dr. Hans Slabbekoorn (University of Leiden), Professor Vincent Janik (University of St Andrews ) and Professor Douglas Wartzok (Florida

  1. Potentiële ziekten en plagen in brandnetel (Urtica dioica) : een beknopt literatuur overzicht

    NARCIS (Netherlands)

    Alebeek, van F.A.N.

    2006-01-01

    Wilde brandnetelvegetaties vormen een biotoop waarin grote aantallen verschillende insecten zich thuis voelen. Slechts een paar soorten bereiken dichtheden die leiden tot zware aantasting van de planten. Het zou kunnen dat bij grootschalige teelten van geselecteerde brandnetelklonen, en door de

  2. Betaalde arbeid als verdringer van vrijwilligerswerk? Overbelasting als mogelijke verklaring

    NARCIS (Netherlands)

    Jo Thijssen; Sascha Kraus-Hoogeveen; Peter Leisink; Angela Kok- van Meer

    2014-01-01

    De afgelopen jaren hebben zich enkele maatschappelijke veranderingen voorgedaan, die wellicht tot schaarste op de Nederlandse vrijwilligersmarkt zouden kunnen leiden. Enerzijds neemt de vraag naar vrijwilligers toe doordat subsidieregelingen versoberen (bijvoorbeeld in zorg en welzijn) en de

  3. [Recent books on international law] / Yoonie Kim, Paul R Williams

    Index Scriptorium Estoniae

    Kim, Yoonie

    2005-01-01

    Arvustus: Lauri Mälksoo. Illegal Annexation and State Continuity : The Case of the Incorporation of the Baltic States by the USSR. Study of the Tension between Normativity and Power in International Law. Leiden ; Boston, 2003

  4. Mittheilungen über Scyphomedusen I

    NARCIS (Netherlands)

    Stiasny, G.

    1921-01-01

    Hiemit beabsichtige ich eine Reihe kleinerer Mittheilungen über Semaeostomeen und Rhizostomeen des Rijksmuseums van Natuurlijke Historie in Leiden zu veröffentlichen, welche die Systematik, Biologie, Entwicklungsgeschichte und Anatomie verschiedener Scyphomedusen behandeln. Die vorliegenden beiden

  5. Role of Transglutaminase 2 in vascular remodeling

    NARCIS (Netherlands)

    van den Akker, H.H.O.

    2011-01-01

    Verschillende vasculaire ziektebeelden, waaronder hoge bloeddruk en verminderde doorbloeding, leiden tot vernauwing van slagadertjes. Het enzym Transglutaminase 2 (TG2) speelt hierbij een belangrijke rol. Jeroen van den Akker onderzocht het achterliggende proces en ontdekte een nieuwe activatieroute

  6. Experimental melanoma metastasis in lungs of mice with congenital coagulation disorders

    NARCIS (Netherlands)

    Brüggemann, Lois W.; Versteeg, Henri H.; Niers, Tatjana M.; Reitsma, Pieter H.; Spek, C. Arnold

    2008-01-01

    Experimental animal studies as well as clinical trials have shown that interventions targeting the blood coagulation cascade inhibit cancer cell metastasis. These data support the hypothesis that congenital prothrombotic disorders, like factor V Leiden, facilitate metastasis whereas bleeding

  7. Detection of antipolymer antibodies (APA) in serum of women with silicone breast implants. Introduction and performance of the assay in the RIVM

    NARCIS (Netherlands)

    de Jong WH; Spiekstra SW; van Loveren H; LPI

    1998-01-01

    Siliconen bevattende borst implantaten (SBI) worden veelvuldig gebruikt om medische en kosmetische redenen. De laatste tijd is een discussie op gang gekomen dat het aanwezig zijn van een siliconen borstimplantaat mogelijk kan leiden tot gezondheidsklachten. Recentelijk is een laboratoriumtest

  8. Gedragsverandering bij diabetes

    NARCIS (Netherlands)

    Ellen Boslooper; Sanne ter Schegget; dr. A.F. de Wild

    2016-01-01

    Gedragseconomen onderzoeken waarom mensen zich vaak niet laten leiden door hun eigen doel, maar door hun omgeving. Zij onderzoeken bijvoorbeeld gedragsverandering, zoals leefstijlaanpassing bij diabetes. Het blijkt dat diverse psychologische en sociologische fenomenen invloed hebben op

  9. Adriaan van Veldhuizen, De partij. Over het politieke leven in de vroege S.D.A.P.

    Directory of Open Access Journals (Sweden)

    Dirk Jan Wolffram

    2016-11-01

    Full Text Available Adriaan van Veldhuizen, De partij. Over het politieke leven in de vroege S.D.A.P. (Dissertatie Universiteit Leiden 2015; Amsterdam: Prometheus/Bert Bakker, 2015, 375 pp., isbn 978 90 3513 857 5.

  10. [Deniss Hanovs, Valdis Tēraudkalns: Ultimate Freedom - no choice] / Olaf Mertelsmann

    Index Scriptorium Estoniae

    Mertelsmann, Olaf, 1969-

    2014-01-01

    Arvustus: Deniss Hanovs, Valdis Tēraudkalns: Ultimate Freedom - no choice. The culture of authoritarianism in Latvia, 1934-1940. (Central and Eastern Europe. Reginal perspectives in global context, Bd. 2.) Brill. Leiden-Boston 2013

  11. Mechanisms of neuro- and cytotoxicity of local anesthetics and their adjuvants

    NARCIS (Netherlands)

    Stevens, M.F.

    2012-01-01

    Plaatselijke verdovingsmiddelen zetten een mechanisme in gang waarbij zenuwcellen zichzelf vernietigen. Dit kan leiden tot zenuwschade. Stevens wilde achterhalen hoe die zenuwschade ontstaat. Hij toont aan dat alle gangbare plaatselijke verdovingsmiddelen een soort zelfmoordmechanisme van

  12. Isaac Vossius’ Sylloge of Greek Technopaegnia

    Directory of Open Access Journals (Sweden)

    Guillermo Galán-Vioque

    2012-05-01

    Full Text Available Tracing the sources that Vossius (1618–1689 used in compiling his anthology of Greek technopaegnia (Leiden ms. Vossius misc. 13 illuminates both his research methods and the evolution of his dispute with Salmasius.

  13. Campylobacteriose in Nederland

    NARCIS (Netherlands)

    Havelaar AH; MGB

    2002-01-01

    Infecties met bacterien van het geslacht Campylobacter vormen een belangrijk volksgezondheidsprobleem in Nederland. Jaarlijks leiden deze infecties tot circa honderdduizend gevallen van gastroenteritis. Daarnaast zijn er ongeveer zestig gevallen van het Guillain-Barre syndroom en enkele duizenden

  14. African Studies Abstracts Online : number 53, 2016

    NARCIS (Netherlands)

    African Studies Centre Leiden (ASCL),

    2016-01-01

    ASA Online provides a quarterly overview of journal articles and edited works on Africa in the field of the social sciences and the humanities available in the ASC library. Issue 53 (2016). African Studies Centre, Leiden.

  15. African Studies Abstracts Online: number 53, 2016

    OpenAIRE

    African Studies Centre Leiden (ASCL)

    2016-01-01

    ASA Online provides a quarterly overview of journal articles and edited works on Africa in the field of the social sciences and the humanities available in the ASC library. Issue 53 (2016). African Studies Centre, Leiden.

  16. Environmental performances of gas pipe materials

    International Nuclear Information System (INIS)

    Van Nifterik, G.

    1996-01-01

    In constructing new gas pipelines energy distribution companies are increasingly dealing with the question of which material has the lowest environmental impact. Gastec (Dutch gas research institute) and the 'Centrum voor Milieukunde Leiden' (Centre for Environmental Studies of the University of Leiden) studied and compared the environmental aspects of such materials. The study concerns the entire life cycle from raw materials production through digging and welding or fusion joining to the moment the materials are discarded as waste. 2 figs

  17. Cognitive function in the oldest old: women perform better than men

    OpenAIRE

    van Exel, E; Gussekloo, J; de Craen, A J M; d Bootsma-van,; Houx, P; Knook, D; Westendorp, R

    2001-01-01

    OBJECTIVE—Limited formal education is associated with poor cognitive function. This could explain sex differences in cognitive function in the oldest old. Whether limited formal education explains differences in cognitive function between elderly women and men was explored.
METHODS—The Leiden 85-plus Study is a population based study investigating all 85 year old inhabitants of Leiden with an overall response rate of 87%. A sample of 599 participants were visited at their...

  18. Book Reviews

    OpenAIRE

    Mary Somers Heidhues; U. Wikan; Henk Schulte Nordholt; Gehan Wijeyewardene; Oscar Salemink; James J. Fox; Jerome Rousseau; H. Claessen; Ratna Saptari; Marijke Barend-van Haeften; Harry A. Poeze; Wolfgang Marschall; G.E. Marrison; H. den Hertog; A. M. Luyendijk-Elshout

    1992-01-01

    - Jet Bakels, Robert Layton, The anthropology of art. Cambridge: Cambridge University Press, 1991, 258 pp. - J.M.S. Baljon, Herman Leonard Beck, De Islam in Nederland: Romancing religion? [Inaugurele rede theologische faculteit Tilburg 14.2.1992.] Tilburg: Tilburg University Press 1992. - R.H. Barnes, J.D.M. Platenkamp, North Halmahera: Non-Austronesian Languages, Austronesian cultures?, Lecture presented to the Oosters Genootschap in Nederland at Leiden on 23 May 1989, Leiden: Oost...

  19. Book reviews

    Directory of Open Access Journals (Sweden)

    Redactie KITLV

    1992-07-01

    Hoogbergen, The Boni Maroon wars in Suriname. Leiden, the Netherlands: E.J. Brill, 1990. xvii + 254 pp. -Rafael Duharte Jiménez, Carlos Esteban Dieve, Los guerrilleros negros: esclavos fugitivos y cimarrones en Santo Domingo. Santo Domingo: Fundación Cultural Dominicana, 1989. 307 pp. -Rosemarijn Hoefte, Hans Ramsoedh, Suriname 1933-1944: koloniale politiek en beleid onder Gouverneur Kielstra. Delft, the Netherlands: Eburon, 1990. 255 pp. -Gert Oostindie, Kees Lagerberg, Onvoltooid verleden: de dekolonisatie van Suriname en de Nederlandse Antillen. Tilburg, the Netherlands: Instituut voor Ontwikkelingsvraagstukken, Katholieke Universiteit Brabant, 1989. ii + 265 pp. -Aisha Khan, Anthony de Verteuil, Eight East Indian immigrants. Port of Spain: Paria, 1989. xiv + 318 pp. -John Stiles, Willie L. Baber, The economizing strategy: an application and critique. New York: Peter Lang, 1988. xiii + 232 pp. -Faye V. Harrison, M.G. Smith, Poverty in Jamaica. Kingston: Institute of social and economic research, 1989. xxii + 167 pp. -Sidney W. Mintz, Dorian Powell ,Street foods of Kingston. Mona, Jamaica: Institute of social and economic research, 1990. xii + 125 pp., Erna Brodber, Eleanor Wint (eds -Yona Jérome, Michel S. Laguerre, Urban poverty in the Caribbean: French Martinique as a social laboratory. New York: St. Martin's Press, 1990. xiv + 181 pp.

  20. ESO and Fokker Space Sign Contract about VLTI Delay Line

    Science.gov (United States)

    1998-03-01

    instruments within the present collaboration. About Fokker Space Fokker Space is the largest company in the Dutch space industry. It is based in Leiden, has 481 employees and an operating income of 220 million Netherlands Guilders in 1996. Fokker Space is mainly active in the field of solar arrays, launcher structures, thermal products, instruments and simulators. It also plays a key role in the development of robotics and is responsible as a prime contractor for the European Robotics Arm (ERA) to be used on the International Space Station. Fokker Space is well embedded in the Dutch aerospace infrastructure, thanks to close relations with the Dutch Space Agency (NIVR) , the National Aerospace Laboratory (NLR) , the Delft University of Technology and other Dutch space industries and institutes like TNO-TPD (Netherlands Organization for Applied Scientific Research - Institute of Applied Physics) . Fokker Space has also entered into strategic partnerships in Europe, Russia and North America. These facts, combined with the long lasting relation with the European Space Agency ESA and with the Dutch Government imply that Fokker Space has secured a solid base for continuation of its business far into the next millennium. Some technical details about the VLTI Delay Line The VLT Delay Line forms an essential part of the VLT Interferometer (VLTI) . It represents the current limit of high technology in this field and includes many innovative features. Some of the technical details are given below. In order to enable a useful combination of the light beams from the individual telescopes of the VLT (that is, to produce interferometric fringes at the focal point), the optical path length differences must be corrected by the Delay Line system. These differences are caused by: * the static geometric path length difference between the telescopes in a certain configuration; * the diurnal motion of the astronomical source during observation due to Earth's rotation; and * the rapid path length

  1. [Proceedings of the VII international symposium 'Cultural heritage in geosciences, mining and metallurgy : libraries, archives, museums' : "Museums and their collections" held at the Nationaal Natuurhistorisch Museum Leiden (The Netherlands), 19-23 May, 2003 / Cor F. Winkler Prins and Stephen K. Donovan (editors)]: Die Schloenbach-Reisestipendien-Stiftung: ein wertvoller Beitrag fur die geowissenschaftliche Forschung und Acquisition für die Sammlungen der Geologischen Reichsanstalt in Wien

    NARCIS (Netherlands)

    Cernajsek, T.

    2004-01-01

    The "Geologischen Bundesanstalt" (GBA: Austrian Geological Survey) still holds hidden treasures. A good example is a collection of bills and other papers labelled "Schloenbach-Reisestipendien-Stiftung" (SF: Schloenbach Foundation for travel grants) accidentally found in the attic. Also in the

  2. Potential for energy saving and renewable energy in Utrecht, Netherlands. Preliminary validation for the Utrecht municipality; Potentieel energiebesparing en duurzame energie Utrecht. Onderbouwingsnotitie voor de gemeente Utrecht

    Energy Technology Data Exchange (ETDEWEB)

    Benner, J.H.B.; Warringa, G.E.A.

    2012-10-15

    Utrecht has stated its intention to achieve CO2 neutrality of the local energy supply by 2030. Having conducted its own exploratory study into the steps that would need to be taken to achieve this aim, City Hall asked CE Delft to pass judgment on the target and how it is hoped to be achieved. While characterized by both CE Delft and interviewed scientists as very substantial, Utrecht's ambitions are also regarded as a worthy aim to pursue. City Hall's estimates of the reduction potential of the envisaged measures 28% of total projected emission cuts in 2030 via energy efficiency measures and 35% via renewable energy - are deemed realistic by CE Delft. Although the potential reduction via all options was estimated on the basis of the maximum feasible potential, there still remains a substantial policy gap. The analysis makes clear that robust policy choices are required in order to come close to achieving the stated ambitions [Dutch] De gemeente Utrecht heeft zich tot doel gesteld om in 2030 de lokale energievoorziening CO2-neutraal te hebben. Binnen de gemeente is een ambtelijke verkenning uitgevoerd naar de maatregelen om invulling te geven aan deze ambitie. Utrecht heeft CE Delft gevraagd een oordeel te geven over de ambitie en de invulling daarvan. De ambitie van Utrecht wordt zowel door CE Delft als geïnterviewde wetenschappers getypeerd als fors, maar tegelijk als een goed punt aan de horizon om naar toe te werken. De inschattingen van Utrecht rond het reductiepotentieel van de maatregelen worden door CE Delft beoordeeld als realistisch. Dit houdt in dat 28% van de totaal verwachte uitstoot in 2030 wordt gereduceerd door besparingsmaatregelen en 35% met de inzet van duurzame energie. Hoewel bij de inschatting van de mogelijke reductie voor alle opties is gerekend met het maximaal haalbare potentieel resteert er een aanzienlijk beleidsgat. De analyse maakt duidelijk dat echte beleidskeuzen nodig zijn om realisatie van de ambitie te benaderen.

  3. Changes in nearshore waves during the active sea/land breeze period off Vengurla, central west coast of India

    Digital Repository Service at National Institute of Oceanography (India)

    Amrutha, M.M.; SanilKumar, V.; Singh, J.

    zones with use of mechanized boats and this area is also extensively used for tourism-related activities. Therefore, it is important to un- derstand the changes in wave parameters during the active land/sea breeze system in the nearshore region... and interaction. The wave computations in Delft3D-wave are stable due to the fully implicit schemes that have been implemented. In the Delft3D-wave module, the governing equation of wave transformation is based on action balance spectrum, in ge- ographical space...

  4. A Real-Time Nearshore Wave and Current Prediction System

    Science.gov (United States)

    2008-01-01

    this component of the The Dclfl3D system, developed by Delft Hydraulics nearshorc modeling system was tailored specifically tbr ( htp :,’www.wldelft.nl...Walstra. DA-., 2004. Keeping it simple by using Tolman. ILL., 2002. U.ser Manual and Systrn [Documentation of complex models, The 6th tnt. Conf. an...Stelling, 6.S., Van Kester, J.A.TM., 1994. Otil the approximation of WL D)elft I lvdratifis. 2001. User Manual l)MIUD-FLIAW. horizontal gradients in

  5. Field analysis of two-dimensional focusing grating

    OpenAIRE

    Borsboom, P.P.; Frankena, H.J.

    1995-01-01

    The method that we have developed [P-P. Borsboom, Ph.D. dissertation (Delft University of Technology, Delft, The Netherlands); P-P. Borsboom and H. J. Frankena, J. Opt. Soc. Am. A 12, 1134–1141 (1995)] is successfully applied to a two-dimensional focusing grating coupler. The field in the focal region has been determined for symmetrical chirped gratings consisting of as many as 124 corrugations. The intensity distribution in the focal region agrees well with the approximate predictions of geo...

  6. Sustainable building; Duurzaam bouwen

    Energy Technology Data Exchange (ETDEWEB)

    Hendriks, Ch.F. [ed.] [Interfacultair Onderzoek Centrum ' De Ecologische Stad' DIOC, Delft (Netherlands)

    1999-07-01

    A complete overview is given of starting points and targets for the sustainable construction of buildings. The notion of sustainable indicates the necessity of managing specific flows: materials, energy, water and transport (traffic). Also, the monitoring and calculation of environmental effects must be clarified by the generally accepted method of life cycle analysis. This book is for the larger part the result of research carried out at the Interdepartmental Research Centre 'The Ecological City' at the Delft University of Technology in Delft, Netherlands. refs.

  7. Improved real-time dosimetry using the radioluminescence signal from Al2O3:C

    DEFF Research Database (Denmark)

    Damkjær, Sidsel Marie Skov; Andersen, Claus Erik; Aznar, Marianne

    2008-01-01

    15th International Conference on Solid State Dosimetry Location: Delft Univ Technol, Delft, NETHERLANDS Date: JUL 08-13, 2007 Abstract: Carbon-doped aluminum oxide (Al2O3:C) is a highly sensitive luminescence material for ionizing radiation dosimetry, and it is well established that the optically...... to greatly reduce the influence of shallow traps in the range from 0 to 3 Gy and the RL dose-rate measurements with a time resolution of 0. 1 s closely matched dose-rate changes monitored with in ionization chamber. (c) 2007 Elsevier Ltd. All rights reserved....

  8. Using the Engineering Design Cycle to Develop Integrated Project Based Learning in Aerospace Engineering

    NARCIS (Netherlands)

    Saunders-Smits, G.N.; Roling, P.; Brügemann, V.; Timmer, N.; Melkert, J.

    2012-01-01

    Over the past four years the Faculty of Aerospace Engineering at Delft University of Technology in the Netherlands has redeveloped its BSc curriculum to mimic an engineering design cycle. Each semester represents a step in the design cycle: exploration; system design; sub-system design; test,

  9. Dutch tests

    NARCIS (Netherlands)

    Pauwelussen, J.P.

    1999-01-01

    For a long time, vehicle technology has been a stimulating and flourishing activity at TNO and the Delft University of Technology. The tire is a key element, and its research into this, that has given both organisations their strong international profile

  10. Testing ground for bio-innovations

    NARCIS (Netherlands)

    Verdult, E.

    2012-01-01

    Scaled-up research is difficult to execute due to the amount of expensive equipment necessary for an individual party. DSM, CSM/Purac and TU Delft have therefore set up a consortium for research into biotechnological processes. With support from the EU and the Ministry of Economic Affairs, some 100

  11. IRI annual report 1989

    International Nuclear Information System (INIS)

    1990-01-01

    In this annual report of the Dutch Interfacultary Reactor Institute, summary reports are presented of current research and teaching activities during 1989 of the departments radiochemistry, radiation chemistry, radiation physics and reactor physics, operation and maintenance of, and experiments with the Delft Hoger Onderwijs reactor, nuclear instrumentation projects and supporting services. (H.W.). 299 refs.; 2 figs.; 7 tabs

  12. Safety in offshore engineering an academic course covering safety in offshore wind

    NARCIS (Netherlands)

    Cerda Salzmann, D.J.

    2011-01-01

    Offshore projects are known for their challenging conditions, generally leading to high risks. Therefore no offshore project can go without a continuous and extensive assessment on safety issues. The Delft University of Technology is currently developing a course "Safety in Offshore Engineering"

  13. The Reclaim Screw in Mammoth Silos Operating on a Free Surface: Comparison Between Horizontal and Inclined Operation on Free Flowing Bulk Solids

    NARCIS (Netherlands)

    Oosterhuis, E.J.; Schott, Dingena; van Wijk, Arjen

    2004-01-01

    Although the screw conveyor, operating on a free surface, has been used for years as reclaim and storage equipment in mammoth silos, there is no documented knowledge about its spill characteristics. Research at Delft University of Technology together with ESI Eurosilo B.V. on the inclined use of the

  14. 78 FR 52560 - Hurricane Sandy Rebuilding Task Force-Rebuild-by-Design; Announcement of Selection of Design Teams

    Science.gov (United States)

    2013-08-23

    ... Infrastructure Planning Program; TU Delft; Project Projects; RFA Investments; IMG Rebel; Center for Urban...; Hargreaves Associates; Alamo Architects; Urban Green Council; Ironstate Development; New City America. SCAPE... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5727-N-02] Hurricane Sandy Rebuilding...

  15. Buoyancy-stirring interactions in a subtropical embayment: a ...

    African Journals Online (AJOL)

    A potential energy anomaly model was used to demonstrate that this periodic component of stratification was largely a result of tidal straining acting locally, with an additional contribution of stratified water advected from outside the bay during the last stages of the flood tide. Simulations using the Delft3D-Flow hydrodynamic ...

  16. Optimal setpoint operation to reduce peak drying of a church organ

    NARCIS (Netherlands)

    Schijndel, van A.W.M.

    2008-01-01

    The paper presents the characteristics of the Walloon Church in Delft (Netherlands) and a description of constraints for the indoor climate, giving criteria for the indoor air temperature and relative humidity with the focus on the preservation of the monumental church organ. The set point operation

  17. Optimal setpoint operation of the climate control of a monumental church

    NARCIS (Netherlands)

    Schijndel, van A.W.M.; Neilen, D.; Schellen, H.L.; Aarle, van M.A.P.; Carmeliet, J.

    2003-01-01

    The paper presents the characteristics of the Walloon Church in Delft (Netherlands) and a description of constraints for the indoor climate, giving criteria for the indoor air temperature and relative humidity with the focus on the preservation of the monumental organ. The setpoint operation of the

  18. Optimal setpoint operation of the climate controle of a monumental church

    NARCIS (Netherlands)

    Schijndel, van A.W.M.

    2003-01-01

    The paper presents the characteristics of the Walloon Church in Delft (Netherlands) and a description of constraints for the indoor climate, giving criteria for the indoor air temperature and relative humidity with the focus on the preservation of the monumental organ. The setpoint operation of the

  19. Optimal setpoint operation of the climate control of a church

    NARCIS (Netherlands)

    Schijndel, van A.W.M.; Schellen, H.L.

    2010-01-01

    The report presents the characteristics of the Walloon Church in Delft (Netherlands) and a description of constraints for the indoor climate, giving criteria for the indoor air temperature and relative humidity with the focus on the preservation of the monumental organ. The setpoint operation of the

  20. Dewatering behavior of fine oil sands tailings : A summary of laboratory results

    NARCIS (Netherlands)

    Yao, Y.; van Tol, A.F.; van Paassen, L.A.; Vardon, P.J.; Sego, D.C.; Wilson, G.W.; Beier, N.A.

    2016-01-01

    To evaluate the disposal technology for fine oil sands tailings, the appropriate engineering properties of the tailings should be ascertained. A laboratory study was conducted by Delft University of Technology (the Netherlands) on the geotechnical properties and dewatering behavior of the fine oil

  1. Sustainability in Design Engineering Education; Experiences in Northern Europe

    NARCIS (Netherlands)

    Dewulf, K.; Wever, R.; Boks, C.; Bakker, C.; D'hulster, F.

    2009-01-01

    In recent years, the implementation of sustainability into the curricula of engineering has become increasingly important. This paper focuses on the experiences of integrating sustainability in Design Engineering education in the academic bachelor programs at Delft University of Technology in The

  2. Universities' Intermediary Role in the "Design for Sustainability" Field

    Science.gov (United States)

    Küçüksayraç, Elif; Wever, Renee; Brezet, Han

    2017-01-01

    Purpose: This paper aims to investigate the intermediary role of universities in spreading design for sustainability into industry. Design/methodology/approach: Three case studies were undertaken on Delft University of Technology, Design for Sustainability Program from The Netherlands; a center on sustainable consumption and production; and Prof.…

  3. Identification of a Cessna Citation II Model Based on Flight Test Data

    NARCIS (Netherlands)

    de Visser, C.C.; Pool, D.M.

    2017-01-01

    As a result of new aviation legislation, from 2019 on all air-carrier pilots are obliged to go through flight simulator-based stall recovery training. For this reason the Control and Simulation division at Delft University of Technology has set up a task force to develop a new methodology for

  4. Respirable dust meter locates super polluters in traffic

    NARCIS (Netherlands)

    Schmidt-Ott's, A.; Kurniawan, A.; Schrauwers, A.

    2006-01-01

    The Netherlands is having trouble with the EU standards for respirable dust (PM 10). The Dutch Council of State recently blocked a number of residential development projects because local conditions failed to meet the PM 10 standard. Research by the Nano Structured Materials group at TU Delft shows

  5. Integrated sensor array for on-line monitoring micro bioreactors

    NARCIS (Netherlands)

    Krommenhoek, E.E.

    2007-01-01

    The “Fed��?batch on a chip��?��?project, which was carried out in close cooperation with the Technical University of Delft, aims to miniaturize and parallelize micro bioreactors suitable for on-line screening of micro-organisms. This thesis describes an electrochemical sensor array which has been

  6. Terrain Relative Navigation for Planetary Landing using Stereo Vision : Measurements Obtained from Hazard Mapping

    NARCIS (Netherlands)

    Woicke, S.; Mooij, E.

    2017-01-01

    As a result of new aviation legislation, from 2019 on all air-carrier pilots are obliged to go through flight simulator-based stall recovery training. For this reason the Control and Simulation division at Delft University of Technology has set up a task force to develop a new methodology for

  7. Development and Realisation of the Concept House ‘Delft’ Prototype : An Example of a Collaborative Concept Development for Energy Positive Apartments

    NARCIS (Netherlands)

    Eekhout, A.J.C.M.; Van Timmeren, A.

    2016-01-01

    The Delft Prototype is a single apartment from a not yet realized Concept House Urban Villa, which consists of 16 apartments on 4 floors. Both the urban villa and the prototype demonstrate the characteristics of high level industrial production with an extremely low ecological footprint, as well as

  8. Passive WiFi monitoring of the rhythm of the campus

    NARCIS (Netherlands)

    Kalogianni, E.; Sileryte, R.; Lam, M.; Zhou, K.; Van der Ham, M.; Van der Spek, S.C.; Verbree, E.

    2015-01-01

    Within this research-driven project, passive WiFi monitoring of WiFi enabled devices was used to detect users (students, employees, visitors) of buildings at the campus of Delft University of Technology to gain insight into the Rhythm of the Campus: the occupation, duration of stay and moving

  9. English Language Test for Scientific Staff at D.U.T.

    NARCIS (Netherlands)

    Klaassen, R.G.; Bos, M.H.P.C.; Roubos, Tim; Veronesi, Daniela; Nickenig, Christoph

    2009-01-01

    Delft University of Technology (DUT) screened her (non-native English) scientific staff on their level of language proficiency over the year academic 2006/2007. In this paper the large scale operation, involving planning, policy decisions, assessment means, advise and training are discussed. Results

  10. Five Years of IT Management Improvement Eight Cases from the Master of IT Management

    CERN Document Server

    De Mari, G

    2009-01-01

    Displays the results of a handful of graduates of the postgraduate Master of IT Management at TU Delft. This title presents summaries of eight these written between 2003 and 2008, selected to provide a picture of a range of graduation projects

  11. SENZ Umbrellas: taking the world by storm

    NARCIS (Netherlands)

    Smits, A.A.J.; Bodewes, W.

    2011-01-01

    This case describes the start-up of SENZ Umbrellas, a Dutch venture founded by three graduates of Delft University of Technology (the Netherlands) who aimed to introduce an asymmetrical, storm-proof umbrella onto a mass-market where product innovation was limited. It demonstrates the marketing

  12. Bed-load transportmeter for find sand "Sphinx"

    NARCIS (Netherlands)

    Vinckers, J.B.; Bijker, E.W.; Schijf, J.B.

    1953-01-01

    A new bed-load transportmeter has been designed particularly for very fine bed material (below 400 micron). The basic conception is the same as for the so-called Delft-bottle used for measuring transport by turbulent suspension. The instrument is of the flow-through type. The flow enters through a

  13. Challenging and valuable

    NARCIS (Netherlands)

    Van Hal, J.D.M.

    2008-01-01

    Challenging and valuable Inaugural speech given on May 7th 2008 at the occasion of the acceptance of the position of Professor Sustainable Housing Transformation at the faculty of Architeeture of the Delft University of Technology by Prof. J.D.M. van Hal MSc PhD.

  14. Uitdagend en waardevol

    NARCIS (Netherlands)

    Van Hal, J.D.M.

    2008-01-01

    Uitdagend en waardevol Intreerede Uitgesproken op 7 mei 2008 ter gelegenheid van de aanvaarding van het ambt van hoogleraar Sustainable Housing Transformation aan de Faculteit Bouwkunde van de Technische Universiteit Delft door Prof. Dr. Ir. J.D.M. van Hal.

  15. Coastal changes, caused by a shallow water sanddam in front of the Delfland coast

    NARCIS (Netherlands)

    Bakker, W.T.; Delver, G.

    1986-01-01

    Along tht coastline at Ter Heijde, near Delft, a dam parallel to the coast in shallow water will be constructed havlng a horizontal crest at the level NAP -3 m on the landward side, merging into the existing coastal profile and having on the seaward side a slope 1:20. The dam will have a length of

  16. Towards sustainable and clean 3D Geoinformation

    NARCIS (Netherlands)

    Stoter, J.E.; Ledoux, H.; Zlatanova, S.; Biljecki, F.; Kolbe, T.H.; Bill, R.; Donaubauer, A.

    2016-01-01

    This paper summarises the on going research activities of the 3D Geoinformation Group at the Delft University of Technology. The main challenge underpinning the research of this group is providing clean and appropriate 3D data about our environment in order to serve a wide variety of applications.

  17. Our start-up could never have been successful

    NARCIS (Netherlands)

    Van Kranendonk, J.; De Leeuw, T.; Bonger, S.

    2014-01-01

    In July 2013, TU Delft alumnus Jan van Kranendonk and his business partner Thomas de Leeuw decided to discontinue their start-up company Sunuru. The reason was that customers were not interested in their ingenious solar project. Van Kranendonk spoke about his failure during the Failcon event in

  18. Control design and optimization for the DOT500 hydraulic wind turbine

    NARCIS (Netherlands)

    Mulders, S.P.; Jager, Stéphane; Diepeveen, N.F.B.; van Wingerden, J.W.

    2017-01-01

    The drivetrain of most wind turbines currently being deployed commercially consists of a rotor-gearboxgenerator configuration in the nacelle. This abstract introduces the control system design and optimization for a wind turbine with a hydraulic drivetrain, based on the Delft Offshore Turbine (DOT)

  19. Centrifuge modeling of LNAPL transport in partially saturated sand

    NARCIS (Netherlands)

    Esposito, G.; Allersma, H.G.B.; Selvadurai, A.P.S.

    1999-01-01

    Model tests were performed at the Geotechnical Centrifuge Facility of Delft University of Technology, The Netherlands, to examine the mechanics of light nonaqueous phase liquid (LNAPL) movement in a partially saturated porous granular medium. The experiment simulated a 2D spill of LNAPL in an

  20. Online math education (MUMIE) for numerical analysis and linear algebra

    NARCIS (Netherlands)

    Vuik, K.; Daalderop, F.; Wilders, P.; Daudt, J.; Van Kints, R.; Koolstra, K.; Van den Oever, J.; Lobbezoo, B.

    2013-01-01

    This report gives an overview of the work done on MUMIE [2] at TU Delft for the academic year 2012 - 2013. Reports from previous years can be found on our relevant support website [3]. In October 2012 there was a kick-off meeting at TU Berlin regarding the S3M2 project [1]. During this meeting,

  1. Bayesian Belief Networks (BBN) and Expert Systems for supporting model based sensor fault detection analysis of smart building systems

    NARCIS (Netherlands)

    Schagen, J.D.; Taal, A.; Itard, L.C.M.; Heiselberg, Per Kvols

    2016-01-01

    The Hague University in Delft uses an advanced climate control system. All sensors and actuators are monitored and deviations from the sensor data are reported daily. The building manager will have to combine the information from the sensor data in order to draw the right conclusions. In this paper,

  2. Noise barriers and the harmonoise sound propagation model

    NARCIS (Netherlands)

    Salomons, E.M.; Maercke, D. van; Randrianoelina, A.

    2009-01-01

    The Harmonoise sound propagation model ('the Harmonoise engineering model') was developed in the European project Harmonoise (2001-2004) for road and rail traffic noise. In 2008, CSTB Grenoble and TNO Delft have prepared a detailed description of the various steps involved in a calculation with the

  3. Formation flying within a constellation of nano-satellites the QB50 mission

    NARCIS (Netherlands)

    Gill, E.K.A.; Sundaramoorthy, P.; Bouwmeester, J.; Zandbergen, B.; Reinhard, R.

    2010-01-01

    QB50 is a mission establishing an international network of 50 nano-satellites for multi-point, in-situ measurements in the lower thermosphere and re-entry research. As part of the QB50 mission, the Delft University of Technology intends to contribute two nano-satellites both being equipped with a

  4. Internet pathfinder SAMCRA for irritation-free internet phoning

    NARCIS (Netherlands)

    Van Mieghem, P.; Kuipers, F.; Van Wayenburg, B.

    2004-01-01

    The growth of the Internet is going to grind to a halt unless fundamental changes are made in its organisation, predicts Piet Van Mieghem, Professor of Telecommunication Networks at TU Delft. Routing, the information highways traffic control system, is already a cause for concern. And, as in the

  5. IRI annual report 1989

    International Nuclear Information System (INIS)

    1990-01-01

    In this annual report of the Dutch Interfacultary Reactor Institute, summary reports are presented of current research and teaching activities during 1989 of the departments radiochemistry, radiation chemistry, radiation physics and reactor physics, operation and maintenance of, and experiments with the Delft Hoger Onderwijs reactor, nuclear instrumentation projects and supporting services. (H.W.). 145 refs.; 20 figs.; 4 fotos; 2 tabs

  6. Evaluation of safety, performance and emissions of synthetic fuel blends in a Cessna Citation II

    NARCIS (Netherlands)

    Snijders, T.A.; Melkert, J.A.

    2011-01-01

    Prior to being used in aviation, alternative fuels have to be tested thoroughly to ensure safe operation. At Delft University of Technology, a test programme was performed to evaluate the safety, performance and emissions of synthetic fuel blends. During test preparations, compatibility of the

  7. Mixing and In situ product removal in micro-bioreactors

    NARCIS (Netherlands)

    Li, X.

    2009-01-01

    Summary Of the thesis :’ Mixing and In-situ product removal in micro bioreactors’ by Xiaonan Li The work presented in this thesis is a part of a large cluster project, which was formed between DSM, Organon, Applikon and two university groups (TU Delft and University of Twente), under the ACTS and

  8. Otoliths of the wolf-fishes (genus Anarrhichas Linnaeus, 1758) from the Northern Atlantic (Pisces, Perciformes)

    NARCIS (Netherlands)

    Nijssen, H.

    1964-01-01

    While working at the Rijksinstituut voor Visserijonderzoek (R.V.I.O.) at IJmuiden, I received through the courtesy of Mr. C. van Delft some specimens of the three northern Atlantic species of wolf-fishes. At IJmuiden they are brought in by commercial trawlers. The only data in the literature known

  9. The physics of big sample instrumental neutron activation analysis

    NARCIS (Netherlands)

    Overwater, R.M.W.

    1994-01-01

    Proefschrift ter verkrijging van de graad van doctor aan de Technische Universiteit Delft, op gezag van de Rector Magnificus Prof.ir. K.F. Wakker, in het openbaar te verdedigen ten overstaan van een commissie, door het College van Dekanen aangewezen, op maandag 14 november 1994 te 16.00 uur.

  10. Making System Dynamics Cool? Using Hot Testing & Teaching Cases

    NARCIS (Netherlands)

    Pruyt, E.

    2009-01-01

    This paper deals with the use of ‘hot’ real-world cases for both testing and teaching purposes such as in the Introductory System Dynamics course at Delft University of Technology in the Netherlands. The paper starts with a brief overview of the System Dynamics curriculum. Then the problem-oriented

  11. Making System Dynamics Cool II : New Hot Teaching and Testing Cases of Increasing Complexity

    NARCIS (Netherlands)

    Pruyt, E.

    2010-01-01

    This follow-up paper presents several actual cases for testing and teaching System Dynamics. The cases were developed between April 2009 and January 2010 for the Introductory System Dynamics courses at Delft University of Technology in the Netherlands. They can be used for teaching and testing

  12. Making System Dynamics Cool III : New Hot Teaching & Testing Cases

    NARCIS (Netherlands)

    Pruyt, E.

    2011-01-01

    This follow-up paper presents seven actual cases for testing and teaching System Dynamics developed and used between January 2010 and January 2011 for one of the largest System Dynamics courses (250+ students per year) at Delft University of Technology in the Netherlands. The cases presented in this

  13. De Bank The Bench

    NARCIS (Netherlands)

    Breen, J.; Olsthoorn, B.

    1996-01-01

    This book and the accompanying exhibition are the result of a Form Studies exercise held at the Faculty of Architecture at Delft University of Technology (TU Dellt). This practical exercise, entitled 'The Beneh', is part of a second year teaching "Block" (coordinated by Max Risselada) with 'Imaging

  14. Strengthening the Link between Theory and Practice in Teaching Design Engineering: An Empirical Study on a New Approach

    Science.gov (United States)

    Tempelman, E.; Pilot, A.

    2011-01-01

    In 2007, the Faculty of Industrial Design Engineering of the Delft University of Technology introduced a new bachelor program. Based on theories of learning and instruction three design principles were used to develop an approach that aims to make it easier for students to bridge the gap between theoretical design engineering courses and practical…

  15. Assessment of concrete characteristics during the deliberate deformation of a flexible mould after casting

    NARCIS (Netherlands)

    Schipper, H.R.; Grunewald, S.; Troian, S.; Raghunath, P.; Schlangen, H.E.J.G.; Copuroglu, O.; Pecur, I.B.; Baricevic, A.; Stirmer, N; Bjegovic, D.

    2017-01-01

    Expensive CNC (computer numerical controlled)-milled formwork is required for the production of double-curved precast concrete elements for cladding or shell structures. The innovative flexible mould method for economically efficient and sustainable production of such elements, developed at Delft

  16. Full vehicle ABS braking using the SWIFT rigid ring tyre model

    NARCIS (Netherlands)

    Pauwelussen, J.P.; Gootjes, L.; Schröder, C.; Köhne, K.-U.; Jansen, S.T.H.; Schmeitz, A.J.C.

    2003-01-01

    In recent years, at the Delft University of Technology and TNO-Automotive and in conjunction with an industrial consortium, a pragmatic tyre model has been developed going by the name SWIFT, which is geared to the analysis of tyre oscillations and its effects on vehicle behaviour. The SWIFT tyre

  17. ThreeFive photonics : searching for the holy grail?

    NARCIS (Netherlands)

    Burg, van J.C.; Berends, J.J.; Dolmans, S.A.M.

    2011-01-01

    In 2001, the Dutch company ThreeFive Photonics was founded by telecom professional Wouter Deelman and PhD student Chretien Herben attached to Delft University of Technology. The founders set out to develop revolutionary opto-electronic chips with the potential to change the telecom industry. That

  18. Call for papers: Cities and Citizenship in Contemporary Latin America and the Caribbean

    NARCIS (Netherlands)

    E.S. Martens (Emiel)

    2016-01-01

    markdownabstractThe Netherlands Association for Latin American and Caribbean Studies (NALACS), in cooperation with the Faculty of Architecture and the Built Environment of the Delft University of Technology, is pleased to announce the joint conference, ‘Cities and Citizenship in Contemporary Latin

  19. Regio producten, Usp of Utopie?

    NARCIS (Netherlands)

    Scheer, F.P.; Snels, J.C.M.A.

    2013-01-01

    Hoe kan de logistiek rondom de vele initiatieven om streekproducten bij de consument te krijgen slimmer worden georganiseerd? Lastig, blijkt uit de discussie tijdens de bijeenkomst over Agrologistiek georganiseerd door het platform Agrologistiek bij Connekt in Delft. Toch lijken de oplossingen

  20. Educating engineering practice in six design projects in a row

    NARCIS (Netherlands)

    Kamp, A.

    2013-01-01

    Tomorrow’s engineers are required to have a good balance between deep working knowledge of engineering sciences and engineering skills. In the Bachelor in Aerospace Engineering at TU Delft, students are educated to master these competences so that they are ready to engineer when they graduate. The

  1. HORECA. Hoger onderwijs reactor elementary core analysis system. User's manual

    International Nuclear Information System (INIS)

    Battum, E. van; Serov, I.V.

    1993-07-01

    HORECA is developed at IRI Delft for quick analysis of power distribution, burnup and safety for the HOR. It can be used for the manual search of a better loading of the reactor. HORECA is based on the Penn State Fuel Management Package and uses the MCRAC code included in this package as a calculation engine. (orig./HP)

  2. Overal robots : automatisering van de liefde tot de dood

    NARCIS (Netherlands)

    Royakkers, L.; Damen, F.; Est, R. van; Besters, M.; Brom, F.; Dorren, G.; Smits, M.W.

    2012-01-01

    Amerikaanse drones, onbemande luchtvaartuigen, vliegen boven Afghanistan, op zoek naar terroristen. Tegelijkertijd speelt in Japan een robot de hoofdrol in een toneelstuk. Eva, een zorgrobot – gebouwd door studenten aan de TU Delft – verricht huishoudelijke taken en voegt zich al lerend naar de

  3. 'Landscape Mirror' & 'Feed the Wind' : Teaching Landscape Architecture on Site at Oerol Festival in the Wadden Sea

    NARCIS (Netherlands)

    Jauslin, D.T.; Bobbink, I.

    2012-01-01

    In the projects 'Landscape Mirror' 2011 and 'Feed the Wind' 2012 students of the Master of Landscape Architecture of the TU Delft have made an interactive project that evolved over the course of Oerol, a unique yearly recurring festival on the Wadden-Sea island Terschelling for landscape theatre &

  4. Physics with low energy pions and muons

    International Nuclear Information System (INIS)

    Konijn, J.

    1981-01-01

    This document is a collection of texts used for a course of lectures given by the author at the Technical University of Delft (NL) in 1981. It is therefore a comprehensive, Dutch language, review article starting with the discovery of pions and muons, describing their properties and finally discussing their applications in low energy physics. (C.F.)

  5. Private equity leveraged buyout and public values : The bankruptcy of Eircom, Ireland

    NARCIS (Netherlands)

    Lemstra, W.; Groenewegen, J.P.M.

    2012-01-01

    In 2008 the Delft University of Technology was commissioned by the Ministry of Economic Affairs of the Netherlands to investigate the potential impact of private equity leverage buy-out in the telecommunication sector on the public values that the government wished to safeguard. The study provided

  6. Thermo-mechanical challenges for quantum devices

    NARCIS (Netherlands)

    Gielen, A.W.J.; McKenzie, F.V.

    2014-01-01

    In the last few years Technical University of Delft, under leadership of Prof.dr.ir. Leo Kouwenhoven, has developed several successful concepts for quantum devices that are suitable for quantum computing and quantum communication. From a quantum research point of view we are still in a very

  7. Een kijkje in de vroegmoderne Nederlandse keuken vanuit archeobotanisch, historisch en experimenteel perspectief

    NARCIS (Netherlands)

    Hondelink, Merit

    2017-01-01

    Past food consumption is traditionally independently studied by two disciplines, namely Archaeology and History. To study the early modern food preparation and consumption by middle class Delft and Antwerp citizens (1500-1850), archaeobotanical material and historical texts are studied as part of

  8. Ethics, Design and Planning of the Built Environment

    NARCIS (Netherlands)

    Basta, C.; Moroni, S.

    2013-01-01

    The book proposes a set of original contributions in research areas shared by planning theory, architectural research, design and ethical inquiry. The contributors gathered in 2010 at the Ethics of the Built Environment seminar organized by the editors at Delft University of Technology. Both

  9. 3, 2, 1, Launch!

    NARCIS (Netherlands)

    De Kat, R.; Saunders-Smits, G.N.

    2009-01-01

    It is important that young people who chose to pursue a degree in engineering stick with their choice. Unfortunately students often loose their motivation during their first year. This paper gives an example of how the Faculty of Aerospace Engineering of Delft University in The Netherlands manages

  10. T-Minus engineering : A company in rocketry

    NARCIS (Netherlands)

    Olthof, H.; Uitendaal, M.

    2013-01-01

    The idea started when a group of students from Delft Aerospace Rocket Engineering were sitting at the breakfast table of the Esrange launch base canteen, in the far north of Sweden. It was the day after the successful launch of the self-built Stratos rocket, that broke the European altitude record

  11. Jacobus Henricus van 't Hoff

    Indian Academy of Sciences (India)

    looks like the attitude of parents about the education of their wards was not ... Polytechnic School at Delft in 1869 and received a Technology. Diploma in 1871. .... was overloaded with the task of giving elementary lectures and evaluating a ...

  12. Modeling ethanol spray jet flame in hot-diluted coflow with transported PDF

    NARCIS (Netherlands)

    Ma, L.; Naud, B.; Roekaerts, D.J.E.M.

    2014-01-01

    MILD Combustion, also known as flameless combustion, is attracting wide scientific interest due to its potential of high efficiency and low NOx emission. This paper focuses on the numerical modeling of one of the ethanol spray flame cases from the Delft Spray-in-Hot-Coflow (DSHC) burner, which has

  13. Persona?based development of a new discovery system using MERESCO open?source components

    NARCIS (Netherlands)

    Clavel, K.

    2009-01-01

    Sophie and Rogier are students at Delft University of Technology. Sophie is a master student of Architecture. She searches for information mostly to get inspired. Sometimes she’s looking for a specific book and uses Amazon first, because she knows what the cover looks like, but can’t remember the

  14. Building a repository on European colonial architecture and town planning

    NARCIS (Netherlands)

    Suijker, P.M.

    2014-01-01

    During the past two years the TU Delft Library has developed a repository to store data about architecture and town planning in the former Dutch colonies. Historical images, books, journals and archives coming from libraries and museums are scanned and stored into the repository. Information about

  15. Visualising pedestrian flow using PGS tracking to improve inner city quality

    NARCIS (Netherlands)

    Van Langelaar, T.; Van der Spek, S.C.

    2010-01-01

    Every environment has its own characteristics and people react individually to that structure; in an interactive, passive or avoiding way. This paper focuses on pedestrian movement in the city centre of Delft, the Netherlands. It is dedicated to find new and exciting ways of improving city centres

  16. The visco-elastic multilayer program VEROAD

    NARCIS (Netherlands)

    Hopman, P.C.

    1996-01-01

    The mathematical principles and derivation of a linear visco-elastic multilayer computer program are described. The mathematical derivation is based on Fourier Transformation. The program is called VEROAD, which is an acronym for Visco-Elastic ROad Analysis Delft. The program allows calculation of

  17. Using GPS-tracking technology for urban design interventions

    NARCIS (Netherlands)

    Van der Spek, S.C.; Van Langelaar, C.M.

    2011-01-01

    The aim of this paper is to express the application of tracking technologies in Urban Design and Planning. Tracking technologies can be used to monitor different user groups in different occasions. Since 2005, TU Delft has explored and developed two types of research using GPS to collect spatio

  18. Water-hydraulic power transmission for offshore wind farms

    NARCIS (Netherlands)

    Diepeveen, N.F.B.; Jarquin Laguna, A.; Kempenaar, A.S.

    2012-01-01

    The current state of the art of offshore wind turbine power transmission technology is expensive, heavy and maintenance intensive. The Delft Offshore Turbine project considers a radically new concept for power transmission in an offshore wind farm: using seawater as power transmission medium. For

  19. Vehicle rollover sensor test modeling

    NARCIS (Netherlands)

    McCoy, R.W.; Chou, C.C.; Velde, R. van de; Twisk, D.; Schie, C. van

    2007-01-01

    A computational model of a mid-size sport utility vehicle was developed using MADYMO. The model includes a detailed description of the suspension system and tire characteristics that incorporated the Delft-Tyre magic formula description. The model was correlated by simulating a vehicle suspension

  20. SMART Infrastructure & Mobility : Exploring Water, Mobility & Infrastructure in São Paulo

    NARCIS (Netherlands)

    Piccinini, D.; Rocco, R.; Bacchin, T.

    2015-01-01

    This booklet presents the outcomes of the 2014 eligible course ‘Smart Infrastructure and Mobility’ (SIM), of the Delft University of Technology, Faculty of Architecture and the Built Environment Urbanism MSc. The course builds on the theme of the São Paulo Water Ring, locally known as ‘Hidro-Anel’ –

  1. Optical performance of B-layer ultra-shallow-junction silicon photodiodes in the VUV spectral range

    NARCIS (Netherlands)

    Shi, L.; Sarubbi, F.; Nanver, L.K.; Kroth, U.; Gottwald, A.; Nihtianov, S.

    2010-01-01

    In recent work, a novel silicon-based photodiode technology was reported to be suitable for producing radiation detectors for 193 nm deep-ultraviolet light and for the extreme-ultraviolet (EUV) spectral range. The devices were developed and fabricated at the Delft Institute of Microsystems and

  2. Inzicht interactie tussen TBM en doorboorde grond

    NARCIS (Netherlands)

    Festa, D.

    2012-01-01

    Doordat er onvoldoende bekend is over de interactie tussen de tunnelboormachine (TBM) en de doorboorde grond zijn zettingspredicties niet altijd realistisch. Daniele Festa, promovendus aan de TU Delft, wil het inzicht in de TBM-grondinteractie verbeteren door enerzijds het gedrag van het boorschild

  3. A Fair Approach to Flooding

    NARCIS (Netherlands)

    Doorn, N.

    2017-01-01

    Floods can be some of the most unexpected and devastating natural phenomena. Reducing their risks everywhere is near impossible, whether due to financial reasons or more physical obstacles. Dr Neelke Doorn at Delft University of Technology is working to improve policies related to water, with the

  4. Nanopow(d)er : Clay improves the mechanical properties of fibre composites

    NARCIS (Netherlands)

    Picken, S.; Elmendorp, S.; Van de Graaf, A.

    2006-01-01

    Lighter, stronger, and best of all, cheaper these are the basic requirements for the development of new high-tech aircraft construction materials. Following the success of the composite material GLARE, Delft University of Technology is again scoring with the development of a new composite material.

  5. Environmental impacts of international shipping. A case study of the port of Rotterdam

    International Nuclear Information System (INIS)

    Den Boer, E.; Verbraak, G.

    2010-01-01

    As part of the project 'Environmental Impacts of International Shipping: the role of ports' of the Working Group on Transport under OECD's Environment Policy Committee, CE Delft carried out this case study focusing on how the port of Rotterdam and the Dutch authorities address the environmental impacts of the port and its interactions with the hinterlands.

  6. Aircraft Performance for Open Air Traffic Simulations

    NARCIS (Netherlands)

    Metz, I.C.; Hoekstra, J.M.; Ellerbroek, J.; Kugler, D.

    2016-01-01

    The BlueSky Open Air Tra_c Simulator developed by the Control & Simulation section of TU Delft aims at supporting research for analysing Air Tra_c Management concepts by providing an open source simulation platform. The goal of this study was to complement BlueSky with aircraft performance

  7. Fulltext PDF

    Indian Academy of Sciences (India)

    from Delft, Netherlands. Making microscopes was Leeuwen- hoek's passion and he used his lenses to observe virtually every- thing around him. His microscope consisted of a single lens ... In 1675, he discovered 'living things' in ordinary ditch water, which ... species and also to produce a systematic classification of them.

  8. Designing socio-technical systems : Structures and processes

    NARCIS (Netherlands)

    Bots, P.W.G.; Van Daalen, C.

    2012-01-01

    The Systems Engineering, Policy Analysis and Management (SEPAM) MSc curriculum taught at Delft University of Technology focuses on the design of socio-technical systems (STS). We teach our students to structure design activities by considering what we call the TIP aspects: Technical systems,

  9. Scaling Flight Tests of Unmanned Air Vehicles

    Science.gov (United States)

    2006-09-01

    wind tunnel experiments, the wind tunnel remains one of the most widely used, useful tools in the field of aerodynamics. Other Scaled Vehicles and...propensity of automobiles. In other research carried out at the University of Delft, Netherlands, the project DAVINCI was developed for

  10. Water hammer and column separation due to accidental simultaneous closure of control valves in a large scale two-phase flow experimental test rig

    NARCIS (Netherlands)

    Bergant, A.; Westende, van 't J.M.C.; Koppel, T.; Gale, J.; Hou, Q.; Pandula, Z.; Tijsseling, A.S.

    2010-01-01

    A large-scale pipeline test rig at Deltares, Delft, The Netherlands has been used for filling and emptying experiments. Tests have been conducted in a horizontal 250 mm diameter PVC pipe of 258 m length with control valves at the downstream and upstream ends. This paper investigates the accidental

  11. Open access wind tunnel measurements of a downwind free yawing wind turbine

    DEFF Research Database (Denmark)

    Verelst, David Robert; Larsen, Torben J.; van Wingerden, Jan-Willem

    2016-01-01

    A series of free yawing wind tunnel experiments was held in the Open Jet Facility (OJF) of the TU Delft. The ≈ 300 W turbine has three blades in a downwind configuration and is optionally free to yaw. Different 1.6m diameter rotor configurations are tested such as blade flexibility and sweep...

  12. Earth, Wind & Fire : Natuurlijke Airconditioning

    NARCIS (Netherlands)

    Bronsema, B.

    2013-01-01

    Collaboration between the Universities of Technology in Delft and Eindhoven has resulted in the development of a new concept for natural air conditioning of buildings. According to the so-called Climate Responsive Architecture developed in this research, the design of the indoor climate system,

  13. A systems description of flow through porous media

    NARCIS (Netherlands)

    Jansen, J.D.

    2013-01-01

    This text forms part of material taught during a course in advanced reservoir simulation at Delft University of Technology over the past 10 years. The contents have also been presented at various short courses for industrial and academic researchers interested in background knowledge needed to

  14. Development and Performance of the 10 kN Hybrid Rocket Motor for the Stratos II Sounding Rocket

    NARCIS (Netherlands)

    Werner, R.M.; Knop, T.R.; Wink, J; Ehlen, J; Huijsman, R; Powell, S; Florea, R.; Wieling, W; Cervone, A.; Zandbergen, B.T.C.

    2016-01-01

    This paper presents the development work of the 10 kN hybrid rocket motor DHX-200 Aurora. The DHX-200 Aurora was developed by Delft Aerospace Rocket Engineering (DARE) to power the Stratos II and Stratos II+ sounding rocket, with the later one being launched in October 2015. Stratos II and Stratos

  15. Modeling of Mud-Wave Interaction: Mud-Induced Wave Transport & Wave-Induced Mud Transport

    National Research Council Canada - National Science Library

    Winterwerp, Johan C

    2007-01-01

    .... Also a new rheological model has been proposed to describe liquefaction of soft mud by waves, and the subsequent strength recovery after the passage of the waves. A scheme is presented on how to implement these formulations in Delft3D.

  16. Perceptions of brick architecture : interview with Jeroen Geurst

    NARCIS (Netherlands)

    Agyin, J.N.K.F.; Jenniskens, D.P.H.

    Jeroen Geurst (1960) studied architecture at Delft University of Technology and co-founded Geurst & Schulze architects with Rens Schulze in 1984. Over the span of more than three decades, the office has developed a large oeuvre of predominantly brick buildings. Geurst furthermore recently

  17. Intending the Faculty and its Relation with the City

    NARCIS (Netherlands)

    Vande Putte, H.

    2014-01-01

    This paper presents an analysis of the preparation of the idea competition 'Building for Bouwkunde' that was held in 2008. The competition intended entrants to design a replacement building for the lost building of the Faculty of Architecture of the Delft University of Technology, based on the

  18. A five-year research program in one book : Reading guide

    NARCIS (Netherlands)

    Kothuis, B.L.M.; Kothuis, Baukje; Kok, Matthijs

    2017-01-01

    Dr. Baukje Kothuis was a Postdoc in the STW-MFFD program at the Faculty of Technology, Policy & Management, TU Delft in the project ‘Integrated design’. Currently she works at the Faculty of Civil Engineering & Geosciences as a researcher in the NWO Program ‘Integral & sustainable design

  19. Modeling, Simulation, and Testing of Surf Kites for Power Generation

    NARCIS (Netherlands)

    Williams, P.; Lansdorp, B.; Ruiterkamp, R.; Ockels, W.J.

    2008-01-01

    Non-powered flight vehicles such as kites can provide a means of transmitting wind energy from higher altitudes to the ground via tethers. At Delft University of Technology, construction and testing of such a high altitude wind machine is ongoing. The concept is called the Laddermill. It generates

  20. Update estimate emissions degassing inland tank vessels

    Energy Technology Data Exchange (ETDEWEB)

    De Buck, A.; Hoen, M. ' t; Den Boer, E.

    2013-11-15

    At the exchange of cargos of petroleum or chemical products, ships can be degassed, resulting in emissions of VOCs (volatile organic compounds). CE Delft investigated the current size of degassing in the Netherlands. Results can serve as a basis for feasible and effective policies.