WorldWideScience

Sample records for delayed motor development

  1. Impact of Compensatory Intervention in 6- to 18-Month-Old Babies at Risk of Motor Development Delays

    Science.gov (United States)

    Müller, Alessandra Bombarda; Saccani, Raquel; Valentini, Nadia Cristina

    2017-01-01

    Purpose: Research indicates that delayed motor development observed in the first years of life can be prevented through compensatory intervention programmes that provide proper care during this critical period of child development. Method: This study analysed the impact of a 12-week compensatory motor intervention programme on 32 babies with…

  2. OJKO-project: Longitudinal study on the development of young children with a serious cognitive and motor developmental delay

    NARCIS (Netherlands)

    Colla, Stephy; Van Keer, Ines; Schalen, Gertruud Henrike; van der Putten, Annette; Visser, Linda; Maes, Bea; Vlaskamp, Carla; van der Meulen, Bieuwe

    2015-01-01

    Recently, a longitudinal project on the development of children with a serious cognitive and motor developmental delay has started in Belgium and the Netherlands. The aims of this study are to evaluate the cognitive, motor, communicative and social-emotional abilities of young children with a severe

  3. Programme to encourage the development of fine motor skills with a girl with developmental delay

    OpenAIRE

    Ivančič, Urška

    2017-01-01

    Movement plays an important role in the integral development of a child. Good motor skills facilitate learning and thus they consequently have a positive impact on improved learning success. The theoretical part presents the importance and role of gross motor skills and its relationship to the development of fine motor skills. More specifically, we have focused on the following: the course of development of fine motor skills, the impact fine motor skills have on the child and we have also loo...

  4. Clonidine treatment delays postnatal motor development and blocks short-term memory in young mice.

    Directory of Open Access Journals (Sweden)

    Cristina Calvino-Núñez

    Full Text Available During the development of the nervous system, the perinatal period is particularly sensitive as neuronal connections are still forming in the brain of the neonate. Alpha2-adrenergic receptors are overexpressed temporarily in proliferative zones in the developing brain, reaching a peak during the first postnatal week of life. Both stimulation and blocking of these receptors during this period alter the development of neural circuits, affecting synaptic connectivity and neuronal responses. They even affect motor and cognitive skills later on in the adult. It's especially important to look for the early neurological consequences resulting from such modifications, because they may go unnoticed. The main objective of the present study has been to reaffirm the importance of the maturation of alpha-adrenergic system in mice, by carrying out a comprehensive examination of motor, behavioral and cognitive effects in neonates, during early postnatal development, following chronic administration of the drug Clonidine, an alpha2 adrenergic system agonist. Our study shows that mice treated postnatally with clonidine present a temporal delay in the appearance of developmental markers, a slow execution of vestibular reflexes during first postnatal week of life and a blockade of the short term memory in the novel object recognition task. Shortly after the treatment the startle response is hyperreactive.

  5. The motor intervention as delays prevention factor in motor and cognitive development of infants during the hospital stay

    Directory of Open Access Journals (Sweden)

    arolina Panceri

    2017-09-01

    Full Text Available Introduction: Cognitive-motor tasks intervention is beneficial for the infant’s motor and cognitive development. These interventions in the hospital setting, have been widely studied in neonatal intensive care units, however, few studies evaluate child development within pediatric units. Objective: To evaluate the impact of cognitive-motor intervention in motor and cognitive development of infants hospitalized with respiratory diseases. Method: The research was characterized as quasi-experimental, 22 babies hospitalized in the pediatric unit for respiratory disease were divided into 2 groups (10 in the control group and 12 in the intervention group without significant differences in biological and socioeconomic data. The mean age was 5.50 months (SD ± 4.51, ranging between 1 and 16 months. Questionnaire was conducted with the infant’s parent/guardian for sample characterization. The Alberta Infant Motor Scale (AIMS and the Bayley Scales of Infant Development (BSID-III was used to evaluate motor e cognitive development. Data analysis was performed using descriptive statistics, Student’s t test, General Linear Model and One Way ANOVA. Results: The results show a significant interaction between group x time in motor and cognitive scores. When comparing the two times, the intervention group changed positively and significantly from pre- to post-intervention in motor and cognitive scores. The same was not observed for the control group. Conclusion: The results of this study suggest that the intervention during the hospital stay contributes positively to the motor and cognitive development.

  6. The Relationship between Motor Delays and Language Development in Very Low Birthweight Premature Children at 18 Months Corrected Age

    Science.gov (United States)

    Ross, Gail; Demaria, Rebecca; Yap, Vivien

    2018-01-01

    Purpose: The aim of this study is to determine if there is a specific association between motor delays and receptive and expressive language function, respectively, in prematurely born children. Method: Retrospective data review: 126 premature children = 1,250-g birthweight from English-speaking families were evaluated on motor development…

  7. Development of an Android OS Based Controller of a Double Motor Propulsion System for Connected Electric Vehicles and Communication Delays Analysis

    Directory of Open Access Journals (Sweden)

    Pedro Daniel Urbina Coronado

    2015-01-01

    Full Text Available Developments of technologies that facilitate vehicle connectivity represent a market demand. In particular, mobile device (MD technology provides advanced user interface, customization, and upgradability characteristics that can facilitate connectivity and possibly aid in the goal of autonomous driving. This work explores the use of a MD in the control system of a conceptual electric vehicle (EV. While the use of MD for real-time control and monitoring has been reported, proper consideration has not been given to delays in data flow and their effects on system performance. The motor of a novel propulsion system for an EV was conditioned to be controlled in a wireless local area network by an ecosystem that includes a MD and an electronic board. An intended accelerator signal is predefined and sent to the motor and rotational speed values produced in the motor are sent back to the MD. Sample periods in which the communication really occurs are registered. Delays in the sample periods and produced errors in the accelerator and rotational speed signals are presented and analyzed. Maximum delays found in communications were of 0.2 s, while the maximum error produced in the accelerator signal was of 3.54%. Delays are also simulated, with a response that is similar to the behavior observed in the experiments.

  8. Exploring the motor development of young children with possible severe to profound cognitive and motor developmental delay by means of a questionnaire

    NARCIS (Netherlands)

    Schalen, Gertruud Henrike; van der Putten, Annette; Maes, Bea; Vlaskamp, Carla

    Aim: Early motor stimulation may be valuable for children with profound intellectual and multiple disabilities (PIMD), however limited knowledge of their typical motor developmental trajectory may be currently restraining the efficacy and specificity of this intervention. Research on young children

  9. Infant Motor Delay and Early Symptomatic Syndromes Eliciting Neurodevelopmental Clinical Examinations in Japan.

    Science.gov (United States)

    Hatakenaka, Yuhei; Kotani, Haruko; Yasumitsu-Lovell, Kahoko; Suzuki, Keita; Fernell, Elisabeth; Gillberg, Christopher

    2016-01-01

    Abnormalities of early motor development have been reported in autism spectrum disorder, attention-deficit/hyperactivity disorder, intellectual developmental disorder, developmental coordination disorder, and other Early Symptomatic Syndromes Eliciting Neurodevelopmental Clinical Examinations (ESSENCE). However, few studies have been conducted with a view to following up a clinically representative cohort of children coming for assessment of motor delay before age two years. We performed a prospective clinical cohort study to examine whether or not early motor delay is often an indication of ESSENCE. The sample comprised a one-year cohort of all children who came to a Japanese neurodevelopmental center before their second birthday because of delayed or abnormal gross motor development. The children were followed up from the ESSENCE viewpoint. Of the 30 children, 28 (18 boys and 10 girls) (93%) were given diagnoses subsumed under the ESSENCE umbrella. Of the 15 children with an identified or strongly suspected etiology, 13 (8 boys and 5 girls) (87%) had ESSENCE disorders or symptoms. Of the 15 children without a known etiology, all had ESSENCE disorders or symptoms. This study indicated that the vast majority of children with motor delay or abnormality in the first two years of life meet criteria for a disorder within the group of ESSENCE at follow-up; this means that young children, presenting with motor problems always need a broad clinical assessment, not just related to motor function, and systematic follow-up. Copyright © 2016 Elsevier Inc. All rights reserved.

  10. Evoluções motoras e linguísticas de bebês com atraso de desenvolvimento na perspectiva de mães Motor and language development of babies with delayed development from the mothers' perspective

    Directory of Open Access Journals (Sweden)

    Tatiany Hekavei

    2009-04-01

    Full Text Available O presente estudo teve por objetivo investigar a evolução do desenvolvimento motor e de linguagem em bebês com atraso de desenvolvimento a partir da perspectiva materna. Participaram do estudo seis mães de bebês com atraso de desenvolvimento. A pesquisa foi realizada numa instituição com programa de intervenção precoce e em ambiente domiciliar. Foram feitas entrevistas com as mães, por meio de um roteiro semiestruturado. O modo de compreensão das mães, tanto do processo de desenvolvimento motor, quanto linguístico dos filhos, indicou uma evolução no desenvolvimento dessas crianças. Uma das provas disso, foi a forma como essas mães se referiram ao desenvolvimento das crianças, antes destas ingressarem no programa de intervenção precoce e no momento atual. Conhecer e valorizar as percepções trazidas pelos cuidadores e particularmente pelas mães, implica em ampliar o entendimento dos seus saberes e práticas. Estes valores, por sua vez, podem ser utilizados no sentido de favorecer todo o processo de desenvolvimento infantil.The aim of the present study was to investigate the evolution of motor and language development in developmentally delayed babies from the mother's perspective. Six mothers of developmentally delayed babies participated in the study. This study was conducted in an institution that had an early intervention program and in the home environment. Interviews with the mothers were conducted using a semi-structured questionnaire. The way the mothers understood both their children's processes of motor and language development was indicative of an evolution in these children's development. The ways these mothers reported on the development of the children before they entered the early intervention program and at present is evidence to this effect. To know and to value the perception that caretakers have about their children has to do with broadening their understanding and practices. These values, in turn, can be

  11. Effect of Group Setting on Gross Motor Performance in Children 3-5 Years Old with Motor Delays.

    Science.gov (United States)

    Fay, Deanne; Wilkinson, Tawna; Wagoner, Michelle; Brooks, Danna; Quinn, Lauren; Turnell, Andrea

    2017-02-01

    The purpose of this study was to evaluate differences in gross motor performance of children 3-5 years of age with motor delays when assessed individually compared to assessment in a group setting among peers with typical development (TD). Twenty children with motor delays and 42 children with TD were recruited from a preschool program. A within-subject repeated measures design was used; each child with delay was tested both in an individual setting and in a group setting with two to four peers with TD. Testing sessions were completed 4-8 days apart. Ten different motor skills from the Peabody Developmental Motor Scales-2 were administered. Performance of each item was videotaped and scored by a blinded researcher. Overall gross motor performance was significantly different (p < .05) between the two settings, with 14 of 20 children demonstrating better performance in the group setting. In particular, children performed better on locomotion items (p < .05). The higher scores for locomotion in the group setting may be due to the influence of competition, motivation, or modeling. Assessing a child in a group setting is recommended as part of the evaluation process.

  12. Normal motor milestone development for use to promote child care

    Directory of Open Access Journals (Sweden)

    Mahdin A. Husaini

    2016-10-01

    Full Text Available Background Motor behavior is an essential aspect of child development, and usually assessed in terms of age of achievement of motor milestone. The early detection of infants experiencing subtle delays in motor maturation can allow early intervention in developmental problems. Intervention can be more effective if delays are identified early. In order to facilitate the identification of early delays, the Center of Nutrition and Foods Research and Development in Bogor has designed a simple tool to monitor the child (aged 3 to 18 months motor development. Objective To develop an observable of normal gross motor maturation for use to detect deviance or motor delay. Methods A total of 2100 healthy children, aged 3-18 months, from high socio-economic group, in urban and suburban areas, were studied. Body length, weight and motor development were measured on all children. Gross motor development was measured 17 pre selected milestones: lie, sit, crawl, creep, stand Mth assistance, walk with assistance, stand alone, walk alone, and run. Results There were no differences between males and females in the comparison of attainment motor maturation therefore a sex combined curve was developed. Conclusion The curve of normal motor milestone development can be used as a tool to evaluate motor development over time, and/or as a child development card for use in primary health care.

  13. Motor development of blind toddler

    OpenAIRE

    Likar, Petra

    2013-01-01

    For blind toddlers, development of motor skills enables possibilities for learning and exploring the environment. The purpose of this graduation thesis is to systematically mark the milestones in development of motor skills in blind toddlers, to establish different factors which affect this development, and to discover different ways for teachers for visually impaired and parents to encourage development of motor skills. It is typical of blind toddlers that they do not experience a wide varie...

  14. Repeated intermittent alcohol exposure during the third trimester-equivalent increases expression of the GABA(A) receptor δ subunit in cerebellar granule neurons and delays motor development in rats.

    Science.gov (United States)

    Diaz, Marvin R; Vollmer, Cyndel C; Zamudio-Bulcock, Paula A; Vollmer, William; Blomquist, Samantha L; Morton, Russell A; Everett, Julie C; Zurek, Agnieszka A; Yu, Jieying; Orser, Beverley A; Valenzuela, C Fernando

    2014-04-01

    Exposure to ethanol (EtOH) during fetal development can lead to long-lasting alterations, including deficits in fine motor skills and motor learning. Studies suggest that these are, in part, a consequence of cerebellar damage. Cerebellar granule neurons (CGNs) are the gateway of information into the cerebellar cortex. Functionally, CGNs are heavily regulated by phasic and tonic GABAergic inhibition from Golgi cell interneurons; however, the effect of EtOH exposure on the development of GABAergic transmission in immature CGNs has not been investigated. To model EtOH exposure during the 3rd trimester-equivalent of human pregnancy, neonatal pups were exposed intermittently to high levels of vaporized EtOH from postnatal day (P) 2 to P12. This exposure gradually increased pup serum EtOH concentrations (SECs) to ∼60 mM (∼0.28 g/dl) during the 4 h of exposure. EtOH levels gradually decreased to baseline 8 h after the end of exposure. Surprisingly, basal tonic and phasic GABAergic currents in CGNs were not significantly affected by postnatal alcohol exposure (PAE). However, PAE increased δ subunit expression at P28 as detected by immunohistochemical and western blot analyses. Also, electrophysiological studies with an agonist that is highly selective for δ-containing GABA(A) receptors, 4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridine-3-ol (THIP), showed an increase in THIP-induced tonic current. Behavioral studies of PAE rats did not reveal any deficits in motor coordination, except for a delay in the acquisition of the mid-air righting reflex that was apparent at P15 to P18. These findings demonstrate that repeated intermittent exposure to high levels of EtOH during the equivalent of the last trimester of human pregnancy has significant but relatively subtle effects on motor coordination and GABAergic transmission in CGNs in rats. Copyright © 2013 Elsevier Ltd. All rights reserved.

  15. Development of delayed radiation necrosis

    International Nuclear Information System (INIS)

    Ohara, ShigFeki; Takagi, Terumasa; Shibata, Taichiro; Nagai, Hajime.

    1983-01-01

    The authors discussed the developing process of delayed radiation necrosis of the brain from the case of a 42-year-old female who developed intracranial hypertension and left hemiparesis 5 and a half years after radiotherapy for pituitary adenoma. The initial sign of radiation necrosis was from a CT scan taken 3 and a half years after radiotherapy showing an irregular low density lesion in the right temporal lobe. CT scan 2 years later demonstrated displacement of the midline structures to the left and a larger low density lesion with partially high density in the right MCA territory that was enhanced with intravenous contrast medium. Recovery after a right temporal lobectomy and administration of steroid hormone were uneventful. Eight months later there were no signs of raised intracranial pressure nor of neurological deficits. Tissues obtained from the right temporal lobe at lobectomy revealed the characteristic changes of delayed radiation necrosis; a mixture of fresh, recent, and old vascular lesions in the same specimen. From these findings, it was speculated that delayed radiation necrosis might initially occur within several years after radiotherapy and might gradually take a progressive and extended course, even in cases whose clinical symptoms develop much later. (author)

  16. Motor delays in MDMA (ecstasy) exposed infants persist to 2 years.

    Science.gov (United States)

    Singer, Lynn T; Moore, Derek G; Min, Meeyoung O; Goodwin, Julia; Turner, John J D; Fulton, Sarah; Parrott, Andrew C

    2016-01-01

    Recreational use of 3,4 methylenedioxymethamphetamine (ecstasy, MDMA) is increasing worldwide. Its use by pregnant women causes concern due to potentially harmful effects on the developing fetus. MDMA, an indirect monoaminergic agonist and reuptake inhibitor, affects the serotonin and dopamine systems. Preclinical studies of fetal exposure demonstrate effects on learning, motor behavior, and memory. In the first human studies, we found prenatal MDMA exposure related to poorer motor development in the first year of life. In the present study we assessed the effects of prenatal exposure to MDMA on the trajectory of child development through 2 years of age. We hypothesized that exposure would be associated with poorer mental and motor outcomes. The DAISY (Drugs and Infancy Study, 2003-2008) employed a prospective longitudinal cohort design to assess recreational drug use during pregnancy and child outcomes in the United Kingdom. Examiners masked to drug exposures followed infants from birth to 4, 12, 18, and 24 months of age. MDMA, cocaine, alcohol, tobacco, cannabis, and other drugs were quantified through a standardized clinical interview. The Bayley Scales (III) of Mental (MDI) and Motor (PDI) Development and the Behavior Rating Scales (BRS) were primary outcome measures. Statistical analyses included a repeated measures mixed model approach controlling for multiple confounders. Participants were pregnant women volunteers, primarily white, of middle class socioeconomic status, average IQ, with some college education, in stable partner relationships. Of 96 women enrolled, children of 93 had at least one follow-up assessment and 81 (87%) had ≥ two assessments. Heavier MDMA exposure (M=1.3±1.4 tablets per week) predicted lower PDI (pMDMA use during pregnancy had motor delays from 4 months to two years of age that were not attributable to other drug or lifestyle factors. Women of child bearing age should be cautioned about the use of MDMA and MDMA-exposed infants

  17. DEVELOPMENT OF FINE MOTOR COORDINATION AND VISUAL-MOTOR INTEGRATION IN PRESCHOOL CHILDREN

    Directory of Open Access Journals (Sweden)

    Haris MEMISEVIC

    2013-03-01

    Full Text Available Fine motor skills are prerequisite for many everyday activities and they are a good predictor of a child's later academic outcome. The goal of the present study was to assess the effects of age on the development of fine motor coordination and visual-motor integration in preschool children. The sample for this study consisted of 276 preschool children from Canton Sara­jevo, Bosnia and Herzegovina. We assessed children's motor skills with Beery Visual Motor Integration Test and Lafayette Pegboard Test. Data were analyzed with one-way ANOVA, followed by planned com­parisons between the age groups. We also performed a regression analysis to assess the influence of age and motor coordination on visual-motor integration. The results showed that age has a great effect on the development of fine motor skills. Furthermore, the results indicated that there are possible sensitive periods at preschool age in which the development of fine motor skills is accelerated. Early intervention specialists should make a thorough evaluations of fine motor skills in preschool children and make motor (rehabilitation programs for children at risk of fine motor delays.

  18. Delayed benefit of naps on motor learning in preschool children.

    Science.gov (United States)

    Desrochers, Phillip C; Kurdziel, Laura B F; Spencer, Rebecca M C

    2016-03-01

    Sleep benefits memory consolidation across a variety of domains in young adults. However, while declarative memories benefit from sleep in young children, such improvements are not consistently seen for procedural skill learning. Here we examined whether performance improvements on a procedural task, although not immediately observed, are evident after a longer delay when augmented by overnight sleep (24 h after learning). We trained 47 children, aged 33-71 months, on a serial reaction time task and, using a within-subject design, evaluated performance at three time points: immediately after learning, after a daytime nap (nap condition) or equivalent wake opportunity (wake condition), and 24 h after learning. Consistent with previous studies, performance improvements following the nap did not differ from performance improvements following an equivalent interval spent awake. However, significant benefits of the nap were found when performance was assessed 24 h after learning. This research demonstrates that motor skill learning is benefited by sleep, but that this benefit is only evident after an extended period of time.

  19. Intelligence quotient discrepancy indicates levels of motor competence in preschool children at risk for developmental delays

    Directory of Open Access Journals (Sweden)

    Yu TY

    2016-02-01

    worse in the VIQ>PIQ group than in the NON and PIQ>VIQ groups. Significant negative correlations between IQD and most of the motor subtests (r=0.31–0.46, P<0.01 were found only in the VIQ>PIQ group.Conclusion: This study demonstrates that 1 IQD indicates the level of motor competence in preschoolers at risk for developmental delays and 2 IQD is negatively associated with motor competence in preschoolers with significant VIQ>PIQ discrepancy. The first finding was that preschoolers with VIQ>PIQ discrepancy greater than 1 SD performed significantly worse on motor competence than did preschoolers without significant IQD and preschoolers with PIQ>VIQ discrepancy greater than 1 SD. However, preschoolers with significant PIQ>VIQ discrepancy performed better on motor competence than did preschoolers without significant IQD, though the difference was not statistically significant. The second finding was that preschoolers with larger VIQ>PIQ discrepancy had worse motor competence in visual-motor integration and body-movement coordination. Professionals should pay attention to the motor development of children with VIQ>PIQ discrepancy and evaluate children’s IQD along with their motor competence. Keywords: IQ discrepancy, motor competence, child

  20. Motor Development and Motor Resonance Difficulties in Autism: Relevance to Early Intervention for Language and Communication Skills

    Directory of Open Access Journals (Sweden)

    Joseph P. Mccleery

    2013-04-01

    Full Text Available Research suggests that a sub-set of children with autism experience notable difficulties and delays in motor skills development, and that a large percentage of children with autism experience deficits in motor resonance. These motor-related deficiencies, which evidence suggests are present from a very early age, are likely to negatively affect social-communicative and language development in this population. Here, we review evidence for delayed, impaired, and atypical motor development in infants and children with autism. We then carefully review and examine the current language and communication-based intervention research that is relevant to motor and motor resonance (i.e., neural mirroring mechanisms activated when we observe the actions of others deficits in children with autism. Finally, we describe research needs and future directions and developments for early interventions aimed at addressing the speech/language and social-communication development difficulties in autism from a motor-related perspective.

  1. Motor development and motor resonance difficulties in autism: relevance to early intervention for language and communication skills

    Science.gov (United States)

    McCleery, Joseph P.; Elliott, Natasha A.; Sampanis, Dimitrios S.; Stefanidou, Chrysi A.

    2013-01-01

    Research suggests that a sub-set of children with autism experience notable difficulties and delays in motor skills development, and that a large percentage of children with autism experience deficits in motor resonance. These motor-related deficiencies, which evidence suggests are present from a very early age, are likely to negatively affect social-communicative and language development in this population. Here, we review evidence for delayed, impaired, and atypical motor development in infants and children with autism. We then carefully review and examine the current language and communication-based intervention research that is relevant to motor and motor resonance (i.e., neural “mirroring” mechanisms activated when we observe the actions of others) deficits in children with autism. Finally, we describe research needs and future directions and developments for early interventions aimed at addressing the speech/language and social-communication development difficulties in autism from a motor-related perspective. PMID:23630476

  2. MOTORIC STIMULATION RELATED TO FINE MOTORIC DEVELOPMENT ON CHILD

    Directory of Open Access Journals (Sweden)

    Mira Triharini

    2017-07-01

    Full Text Available Introduction: Motor developmental stimulation is an activity undertaken to stimulate the children basic skills and so they can grow and develop optimally. Children who obtain a direct stimulus will grow faster than who get less stimulus. Mother’s behavior of stimulation is very important for children, it is considering as the basic needs of children and it must be fulfilled. Providing good stimulation could optimize fine motor development in children. The purpose of this study was to analyze mother’s behavior about motor stimulation with fine motor development in toddler age 4-5 years old. Method: Design have been  used in this study was cross sectional. Population were mothers and their toddler in Group A of Dharma Wanita Persatuan Driyorejo Gresik Preschool. Sample were 51 respondents recruited by using purposive sampling technique according to inclusion and exclusion criteria. The independent variable was mother’s behavior about motor stimulation whereas dependent variable was fine motor development in toddler. The data were collected using questionnaire and conducting observation on fine motor development based on Denver Development Screening Test (DDST. Data then analyzed using Spearman Rho (r test to find relation between mother’s behaviors about stimulation motor on their toddler fine motor development. Result: Results  of this study showed that there were correlations between mother’s knowledge and fine motor development in toddler (p=0.000, between mother’s attitude and fine motor development in toddler (p=0.000, and between mother’s actions and fine motor development in toddler (p=0.000. Analysis: In sort study found that there were relation between fine motor development and mother’s behavior. Discussion: Therefore mother’s behavior needed to be improved. Further research about stimulation motor and fine motor development aspects in toddler is required.

  3. Gastrointestinal motor mechanisms in hyperglycaemia induced delayed gastric emptying in type I diabetes mellitus

    NARCIS (Netherlands)

    Samsom, M.; Akkermans, L. M.; Jebbink, R. J.; van Isselt, H.; vanBerge-Henegouwen, G. P.; Smout, A. J.

    1997-01-01

    BACKGROUND: Hyperglycaemia delays gastric emptying, both in healthy controls and in patients with diabetes mellitus. The effect of hyperglycaemia on antroduodenal motility in diabetes has not yet been studied. AIM: To investigate the gastrointestinal motor mechanisms involved in the hyperglycaemia

  4. Technology and Motor Ability Development

    Science.gov (United States)

    Wang, Lin; Lang, Yong; Luo, Zhongmin

    2014-01-01

    As a new member joining the technology family, active video games have been developed to promote physical exercise. This working-in-progress paper shares an ongoing project on examining the basic motor abilities that are enhanced through participating in commercially available active video games. [For the full proceedings see ED557181.

  5. Accuracy of the Alberta Infant Motor Scale (AIMS) to detect developmental delay of gross motor skills in preterm infants: a systematic review.

    Science.gov (United States)

    de Albuquerque, Plínio Luna; Lemos, Andrea; Guerra, Miriam Queiroz de Farias; Eickmann, Sophie Helena

    2015-02-01

    To assess, through a systematic review, the ability of Alberta Infant Motor Scale (AIMS) to diagnose delayed motor development in preterm infants. Systematic searches identified five studies meeting inclusion criteria. These studies were evaluated in terms of: participants' characteristics, main results and risk of bias. The risk of bias was assessed with the Quality Assessment of Diagnostic Accuracy Studies--second edition (QUADAS-2). All five studies included a high risk of bias in at least one of the assessed fields. The most frequent biases included were presented in patient selection and lost follow up. All studies used the Pearson correlation coefficient to assess the diagnostic capability of the Alberta Infant Motor Scale. None of the assessed studies used psychometric measures to analyze the data. Given the evidence, the research supporting the ability of Alberta Infant Motor Scale to diagnose delayed motor development in preterm infants presents limitations. Further studies are suggested in order to avoid the above-mentioned biases to assess the Alberta Infant Motor Scale accuracy in preterm babies.

  6. Time delays, population, and economic development

    Science.gov (United States)

    Gori, Luca; Guerrini, Luca; Sodini, Mauro

    2018-05-01

    This research develops an augmented Solow model with population dynamics and time delays. The model produces either a single stationary state or multiple stationary states (able to characterise different development regimes). The existence of time delays may cause persistent fluctuations in both economic and demographic variables. In addition, the work identifies in a simple way the reasons why economics affects demographics and vice versa.

  7. Does Bilingualism Delay the Development of Dementia?

    OpenAIRE

    Amy L Atkinson

    2016-01-01

    It has been suggested that bilingualism (where individuals speak two languages) may delay the development of dementia. However, much of the research is inconclusive. Some researchers have reported that bilingualism delays the onset and diagnosis of dementia, whilst other studies have found weak or even detrimental effects. This paper reviews a series of nine empirical studies, published up until March 2016, which investigated whether bilingualism significantly delays the onset of dementia. Th...

  8. Evaluation of motor development in children with learning disabilities

    Directory of Open Access Journals (Sweden)

    Josiane Medina-Papst

    2010-01-01

    Full Text Available The aim of this study was to determine whether children with learning disabilities present any impairment in the components of motor development. Thirty children (21 boys and 9 girls, aged 8 to 10 years, with learning difficulties in school were studied. The Motor Development Scale was used to evaluate the development of the children in terms of fine motor control, gross motor control, balance, body scheme, spatial organization, and temporal organization. A deficit in the development of the body scheme component was observed for all three age groups, as well as a delayed motor development in terms of balance and gross motor control. No significant differences in general motor age were observed between (age groups. In conclusion, the children studied, especially older ones, presented motor deficits in most of the components evaluated. The inclusion of tasks that assist in the development of motor components, in addition to regular school tasks, is recommended to improve the process of learning in these children..

  9. Comparison of motor delays in young children with fetal alcohol syndrome to those with prenatal alcohol exposure and with no prenatal alcohol exposure.

    Science.gov (United States)

    Kalberg, Wendy O; Provost, Beth; Tollison, Sean J; Tabachnick, Barbara G; Robinson, Luther K; Eugene Hoyme, H; Trujillo, Phyllis M; Buckley, David; Aragon, Alfredo S; May, Philip A

    2006-12-01

    Researchers are increasingly considering the importance of motor functioning of children with fetal alcohol spectrum disorder (FASD). The purpose of this study was to assess the motor development of young children with fetal alcohol syndrome (FAS) to determine the presence and degree of delay in their motor skills and to compare their motor development with that of matched children without FAS. The motor development of 14 children ages 20 to 68 months identified with FAS was assessed using the Vineland Adaptive Behavior Scales (VABS). In addition, 2 comparison groups were utilized. Eleven of the children with FAS were matched for chronological age, gender, ethnicity, and communication age to: (1) 11 children with prenatal alcohol exposure who did not have FAS and (2) 11 matched children without any reported prenatal alcohol exposure. The motor scores on the VABS were compared among the 3 groups. Most of the young children with FAS in this study showed clinically important delays in their motor development as measured on the VABS Motor Domain, and their fine motor skills were significantly more delayed than their gross motor skills. In the group comparisons, the young children with FAS had significantly lower Motor Domain standard (MotorSS) scores than the children not exposed to alcohol prenatally. They also had significantly lower Fine Motor Developmental Quotients than the children in both the other groups. No significant group differences were found in gross motor scores. For MotorSS scores and Fine Motor Developmental Quotients, the means and standard errors indicated a continuum in the scores from FAS to prenatal alcohol exposure to nonexposure. These findings strongly suggest that all young children with FAS should receive complete developmental evaluations that include assessment of their motor functioning, to identify problem areas and provide access to developmental intervention programs that target deficit areas such as fine motor skills. Fine motor

  10. Individualized behavioral assessments and maternal ratings of mastery motivation in mental age-matched toddlers with and without motor delay.

    Science.gov (United States)

    Wang, Pei-Jung; Morgan, George A; Hwang, Ai-Wen; Liao, Hua-Fang

    2013-01-01

    Mastery motivation is a precursor of future developmental outcomes. Evidence about whether toddlers with motor delay have lower mastery motivation is inconclusive. The purpose of this study was to examine differences between mental age-matched toddlers with and without motor delay on various mastery motivation indicators. A mental age- and sex-matched case-control study was performed. Twenty-two children with motor delay, aged 23 to 47 months, and 22 children who were developing typically, aged 15 to 29 months, were recruited. Persistence and mastery pleasure were measured with behavioral tasks that were moderately challenging for each child and with maternal ratings using the Dimensions of Mastery Questionnaire (DMQ). The DMQ was rated by each child's mother based on her perception of her child's motivation. Two types of structured tasks (a puzzle and a cause-effect toy selected to be moderately challenging for each child) were administered in a laboratory setting and recorded on videos. Paired t tests or Wilcoxon signed rank tests were used to examine group differences in persistence and mastery pleasure (α=.007, 2-tailed). Children with motor delay were rated lower on DMQ persistence than the typically developing group, but they did not show significantly lower persistence on the structured tasks. There were no significant differences in mastery pleasure between the 2 groups on either measure. Large within-sample variability on the tasks and small sample size makes subgroup analysis (eg, different severities) difficult. Toddlers with motor delay did not show lower persistence and pleasure when given tasks that were moderately challenging; however, their mothers tended to view them as having lower motivation. Clinicians and parents should provide appropriately challenging tasks to increase children's success and motivation.

  11. Auditory-Motor Interactions in Pediatric Motor Speech Disorders: Neurocomputational Modeling of Disordered Development

    Science.gov (United States)

    Terband, H.; Maassen, B.; Guenther, F.H.; Brumberg, J.

    2014-01-01

    Background/Purpose Differentiating the symptom complex due to phonological-level disorders, speech delay and pediatric motor speech disorders is a controversial issue in the field of pediatric speech and language pathology. The present study investigated the developmental interaction between neurological deficits in auditory and motor processes using computational modeling with the DIVA model. Method In a series of computer simulations, we investigated the effect of a motor processing deficit alone (MPD), and the effect of a motor processing deficit in combination with an auditory processing deficit (MPD+APD) on the trajectory and endpoint of speech motor development in the DIVA model. Results Simulation results showed that a motor programming deficit predominantly leads to deterioration on the phonological level (phonemic mappings) when auditory self-monitoring is intact, and on the systemic level (systemic mapping) if auditory self-monitoring is impaired. Conclusions These findings suggest a close relation between quality of auditory self-monitoring and the involvement of phonological vs. motor processes in children with pediatric motor speech disorders. It is suggested that MPD+APD might be involved in typically apraxic speech output disorders and MPD in pediatric motor speech disorders that also have a phonological component. Possibilities to verify these hypotheses using empirical data collected from human subjects are discussed. PMID:24491630

  12. Auditory-motor interactions in pediatric motor speech disorders: neurocomputational modeling of disordered development.

    Science.gov (United States)

    Terband, H; Maassen, B; Guenther, F H; Brumberg, J

    2014-01-01

    Differentiating the symptom complex due to phonological-level disorders, speech delay and pediatric motor speech disorders is a controversial issue in the field of pediatric speech and language pathology. The present study investigated the developmental interaction between neurological deficits in auditory and motor processes using computational modeling with the DIVA model. In a series of computer simulations, we investigated the effect of a motor processing deficit alone (MPD), and the effect of a motor processing deficit in combination with an auditory processing deficit (MPD+APD) on the trajectory and endpoint of speech motor development in the DIVA model. Simulation results showed that a motor programming deficit predominantly leads to deterioration on the phonological level (phonemic mappings) when auditory self-monitoring is intact, and on the systemic level (systemic mapping) if auditory self-monitoring is impaired. These findings suggest a close relation between quality of auditory self-monitoring and the involvement of phonological vs. motor processes in children with pediatric motor speech disorders. It is suggested that MPD+APD might be involved in typically apraxic speech output disorders and MPD in pediatric motor speech disorders that also have a phonological component. Possibilities to verify these hypotheses using empirical data collected from human subjects are discussed. The reader will be able to: (1) identify the difficulties in studying disordered speech motor development; (2) describe the differences in speech motor characteristics between SSD and subtype CAS; (3) describe the different types of learning that occur in the sensory-motor system during babbling and early speech acquisition; (4) identify the neural control subsystems involved in speech production; (5) describe the potential role of auditory self-monitoring in developmental speech disorders. Copyright © 2014 Elsevier Inc. All rights reserved.

  13. Delay-related cerebral activity and motor preparation

    NARCIS (Netherlands)

    Mars, R.B.; Coles, M.G.H.; Hulstijn, W.

    2008-01-01

    Flexible goal-oriented behavior requires the ability to carry information across temporal delays. This ability is associated with sustained neural firing. In cognitive terms, this ability has often been associated with the maintenance of sensory material online, as during short-term memory tasks, or

  14. Delayed Speech or Language Development

    Science.gov (United States)

    ... Parents Parents site Sitio para padres General Health Growth & Development Infections Diseases & Conditions Pregnancy & Baby Nutrition & Fitness Emotions & ... dada" well before their first birthday, and most toddlers can say about 20 words by the time ...

  15. Delays in early neuropsychic development: Approaches to diagnosis

    Directory of Open Access Journals (Sweden)

    N. N. Zavadenko

    2015-01-01

    Full Text Available The population frequency of neuropsychic developmental delays in infants is estimated at nearly 10%; that of global intellectual disability (mental retardation is at 1-3%. Delayed development is denned as a substantial retardation as compared to the standard indicators in any of the basic spheres: motor, communicative, cognitive, adaptive-behavioral, and socioemotional ones. Global developmental delay is characterized by a significant lag in two or more spheres. The use of current diagnostic techniques, such as the Bayley or Griffiths scales, can provide an objective quantitative assessment of both an infant's overall development and indicators in individual spheres. At the preliminary examination stage, it is expedient to carry out a Denver developmental screening test that may be directly used in a doctor's consulting room. The causes of global developmental delay/intellectual disability in infants may be perinatal central nervous system (CNS lesions; brain malformations; intrauterine infections; intrauterine intoxications; early-onset psychoneurological diseases (neuroinfections, CNS injuries, epilepsies, autism spectrum disorders, etc.; congenital hypothyroidism; genetic diseases. Among all genetic causes of global developmental delay/intellectual disability, there are chromosomal anomalies (25-30%, monogenic diseases (metabolic diseases, neuroectodermal syndromes, diseases with predominant grey and white matter involvement. The diagnostic possibilities of current genetic methods are considered.

  16. Permanent molars: Delayed development and eruption

    Directory of Open Access Journals (Sweden)

    Arathi R

    2006-05-01

    Full Text Available Delayed development and eruption of all the permanent molars is a rare phenomenon, which can cause disturbance in the developing occlusion. The eruption of permanent first and second molars is very important for the coordination of facial growth and for providing sufficient occlusal support for undisturbed mastication. In the case described, the first permanent molars were delayed in their development and were seen erupting at the age of nine and a half years. Severe disparity between the left and the right side of the dentition with respect to the rate of development of molars were also present.

  17. RhoE deficiency produces postnatal lethality, profound motor deficits and neurodevelopmental delay in mice.

    Directory of Open Access Journals (Sweden)

    Enric Mocholí

    Full Text Available Rnd proteins are a subfamily of Rho GTPases involved in the control of actin cytoskeleton dynamics and other cell functions such as motility, proliferation and survival. Unlike other members of the Rho family, Rnd proteins lack GTPase activity and therefore remain constitutively active. We have recently described that RhoE/Rnd3 is expressed in the Central Nervous System and that it has a role in promoting neurite formation. Despite their possible relevance during development, the role of Rnd proteins in vivo is not known. To get insight into the in vivo function of RhoE we have generated mice lacking RhoE expression by an exon trapping cassette. RhoE null mice (RhoE gt/gt are smaller at birth, display growth retardation and early postnatal death since only half of RhoE gt/gt mice survive beyond postnatal day (PD 15 and 100% are dead by PD 29. RhoE gt/gt mice show an abnormal body position with profound motor impairment and impaired performance in most neurobehavioral tests. Null mutant mice are hypoactive, show an immature locomotor pattern and display a significant delay in the appearance of the hindlimb mature responses. Moreover, they perform worse than the control littermates in the wire suspension, vertical climbing and clinging, righting reflex and negative geotaxis tests. Also, RhoE ablation results in a delay of neuromuscular maturation and in a reduction in the number of spinal motor neurons. Finally, RhoE gt/gt mice lack the common peroneal nerve and, consequently, show a complete atrophy of the target muscles. This is the first model to study the in vivo functions of a member of the Rnd subfamily of proteins, revealing the important role of Rnd3/RhoE in the normal development and suggesting the possible involvement of this protein in neurological disorders.

  18. Does Bilingualism Delay the Development of Dementia?

    Directory of Open Access Journals (Sweden)

    Amy L Atkinson

    2016-08-01

    Full Text Available It has been suggested that bilingualism (where individuals speak two languages may delay the development of dementia. However, much of the research is inconclusive. Some researchers have reported that bilingualism delays the onset and diagnosis of dementia, whilst other studies have found weak or even detrimental effects. This paper reviews a series of nine empirical studies, published up until March 2016, which investigated whether bilingualism significantly delays the onset of dementia. The article also explores whether the inconsistent findings can be attributed to differences in study designs or the definitions of bilingualism used between studies. Based on current evidence, it appears that lifelong bilingualism, where individuals frequently use both languages, may be protective against dementia. However, becoming bilingual in adulthood or using the second language infrequently is unlikely to substantially delay onset of the disease.

  19. Motor Development Programming in Trisomic-21 Babies

    Science.gov (United States)

    Sanz, Teresa; Menendez, Javier; Rosique, Teresa

    2011-01-01

    The present study contributes to the understanding of gross motor development in babies with Down's syndrome. Also, it facilitates the comprehension of the efficiency of the early motor stimulation as well as of beginning it as early as possible. We worked with two groups of babies with Down's syndrome, beginning the early motor training in each…

  20. Motor Asymmetry and Substantia Nigra Volume Are Related to Spatial Delayed Response Performance in Parkinson Disease

    Science.gov (United States)

    Foster, Erin R.; Black, Kevin J.; Antenor-Dorsey, Jo Ann V.; Perlmutter, Joel S.; Hershey, Tamara

    2008-01-01

    Studies suggest motor deficit asymmetry may help predict the pattern of cognitive impairment in individuals with Parkinson disease (PD). We tested this hypothesis using a highly validated and sensitive spatial memory task, spatial delayed response (SDR), and clinical and neuroimaging measures of PD asymmetry. We predicted SDR performance would be…

  1. Motor development of children with attention deficit hyperactivity disorder

    Directory of Open Access Journals (Sweden)

    Francisco Rosa Neto

    2015-09-01

    Full Text Available Objective:To compare both global and specific domains of motor development of children with attention deficit hyperactivity disorder (ADHD with that of typically developing children.Methods:Two hundred children (50 children with clinical diagnoses of ADHD, according to the DSM-IV-TR and 150 typically developing controls, aged 5 to 10 years, participated in this cross-sectional study. The Motor Development Scale was used to assess fine and global motricity, balance, body schema, and spatial and temporal organization.Results:Between-group testing revealed statistically significant differences between the ADHD and control groups for all domains. The results also revealed a deficit of nearly two years in the motor development of children with ADHD compared with the normative sample.Conclusion:The current study shows that ADHD is associated with a delay in motor development when compared to typically developing children. The results also suggested difficulties in certain motor areas for those with ADHD. These results may point to plausible mechanisms underlying the relationship between ADHD and motor difficulties.

  2. Television viewing associates with delayed language development.

    Science.gov (United States)

    Chonchaiya, Weerasak; Pruksananonda, Chandhita

    2008-07-01

    To identify impact of television viewing on language development. The case-control study included 56 new patients with language delay and 110 normal children, aged 15-48 months. Language delay was diagnosed by reviewing language milestones and Denver-II. Television viewing variables and child/parental characteristics between both groups were interviewed. The data were analyzed by ANOVA and chi-square test. Adjusted odds ratios and 95% confidence intervals were calculated from multivariate logistic regression model. Forty-six boys and 10 girls; mean [+/-SD] age, 2.11+/-0.47 years of the case group and 59 boys and 51 girls; mean [+/-SD] age, 2.23+/-0.80 years of the control group were enrolled. Children who had language delay usually started watching television earlier at age 7.22+/-5.52 months vs. 11.92+/-5.86 months, p-valuetelevision than normal children (3.05+/-1.90 h/day vs. 1.85+/-1.18 h/day; p-valuetelevision attelevision>2 h/day were approximately six times more likely to have language delays. There is a relationship between early onset and high frequency of TV viewing and language delay.

  3. Better working memory and motor inhibition in children who delayed gratification

    Directory of Open Access Journals (Sweden)

    Junhong Yu

    2016-07-01

    Full Text Available Background: Despite the extensive research on delayed gratification over the past few decades, the neurocognitive processes that subserve delayed gratification remains unclear. As an exploratory step in studying these processes, the present study aims to describe the executive function profiles of children who were successful at delaying gratification and those who were not. =Methods: A total of 138 kindergarten students (65 males, 73 females; Mage = 44 months, SD= 3.5; age range= 37 to 53 months were administered a delayed gratification task, a 1-back test, a Day/night Stroop test and a Go/no-go test. The outcome measures of these tests were then analyzed between groups using a Multivariate Analysis of Variance, and subsequently a Multivariate Analysis of Covariance incorporating age as a covariate.Results: Children who were successful in delaying gratification were significantly older and had significantly better outcomes in the 1-back test and go/no-go test. With the exception of the number of hits in the go/no-go test, all other group differences remained significant after controlling for age.Conclusion:Children who were successful in delaying gratification showed better working memory and motor inhibition relative to those who failed the delayed gratification task. The implications of these findings are discussed

  4. Better Working Memory and Motor Inhibition in Children Who Delayed Gratification

    Science.gov (United States)

    Yu, Junhong; Kam, Chi-Ming; Lee, Tatia M. C.

    2016-01-01

    Background: Despite the extensive research on delayed gratification over the past few decades, the neurocognitive processes that subserve delayed gratification remains unclear. As an exploratory step in studying these processes, the present study aims to describe the executive function profiles of children who were successful at delaying gratification and those who were not. Methods: A total of 138 kindergarten students (65 males, 73 females; Mage = 44 months, SD = 3.5; age range = 37–53 months) were administered a delayed gratification task, a 1-back test, a Day/night Stroop test and a Go/no-go test. The outcome measures of these tests were then analyzed between groups using a Multivariate Analysis of Variance, and subsequently a Multivariate Analysis of Covariance incorporating age as a covariate. Results: Children who were successful in delaying gratification were significantly older and had significantly better outcomes in the 1-back test and go/no-go test. With the exception of the number of hits in the go/no-go test, all other group differences remained significant after controlling for age. Conclusion: Children who were successful in delaying gratification showed better working memory and motor inhibition relative to those who failed the delayed gratification task. The implications of these findings are discussed. PMID:27493638

  5. Effects of overweight and obesity on motor and mental development in infants and toddlers.

    Science.gov (United States)

    Cataldo, R; Huang, J; Calixte, R; Wong, A T; Bianchi-Hayes, J; Pati, S

    2016-10-01

    A consequence of childhood obesity may be poor developmental outcomes. This study aimed to examine the relationship between weight and developmental delays in young children. We conducted a secondary analysis of the Early Childhood Longitudinal Study Birth Cohort data. Logistic regression models quantified the association between different weight statuses (normal weight obese ≥95th percentile for weight) and delays in motor and mental development. Children classified as overweight in both waves had higher percentages of delays in wave 2 (motor [7.5 vs. 6.2-6.4%], mental [8.6 vs. 5.9-6.7%]), as well as wave 1 and/or wave 2 (motor [14.8 vs. 10.9-13.0%], mental [11.9 vs. 9.0-10.1%]), compared with other children. This association was also found in children who were obese at both time points in wave 2 (motor delay [8.9 vs. 4.9-7.3%], mental delay [10.3 vs. 6.0-7.2%]), as well as wave 1 and/or wave 2 (motor delay [14.5 vs. 10.9-12.9%], mental delay [14.1 vs. 9.4-10.1%]). In the adjusted models, children classified as always obese were more likely to have a mental delay in wave 2 (adjusted odds ratio [aOR] 1.89, 95% confidence interval [CI]: 1.21-2.95) as well as wave 1 and/or wave 2 (aOR 1.56, 95% CI: 1.08-2.26). These children were also more likely to have motor delay (aOR 1.47, 95% CI: 1.02-2.13) in wave 1 and/or wave 2. Overweight children are more likely than their normal-weight peers to have motor and mental developmental delays. Preventing obesity during infancy may facilitate reducing developmental delays in young children. © 2015 World Obesity.

  6. Development of delayed radiation necrosis. Case report

    Energy Technology Data Exchange (ETDEWEB)

    Ohara, ShigFeki; Takagi, Terumasa [Meitetsu Hospital, Nagoya (Japan); Shibata, Taichiro; Nagai, Hajime

    1983-04-01

    The authors discussed the developing process of delayed radiation necrosis of the brain from the case of a 42-year-old female who developed intracranial hypertension and left hemiparesis 5 and a half years after radiotherapy for pituitary adenoma. The initial sign of radiation necrosis was from a CT scan taken 3 and a half years after radiotherapy showing an irregular low density lesion in the right temporal lobe. CT scan 2 years later demonstrated displacement of the midline structures to the left and a larger low density lesion with partially high density in the right MCA territory that was enhanced with intravenous contrast medium. Recovery after a right temporal lobectomy and administration of steroid hormone were uneventful. Eight months later there were no signs of raised intracranial pressure nor of neurological deficits. Tissues obtained from the right temporal lobe at lobectomy revealed the characteristic changes of delayed radiation necrosis; a mixture of fresh, recent, and old vascular lesions in the same specimen. From these findings, it was speculated that delayed radiation necrosis might initially occur within several years after radiotherapy and might gradually take a progressive and extended course, even in cases whose clinical symptoms develop much later.

  7. A dynamical systems approach to motor development.

    Science.gov (United States)

    Kamm, K; Thelen, E; Jensen, J L

    1990-12-01

    The study of motor development has long influenced the clinical practice of physical therapy. We first review the contributions and deficiencies of two traditional maturational and reflex-based models of motor development. Second, we describe basic principles of kinematic and kinetic analyses of movement and show how we have applied these techniques to understand infant stepping and kicking. Third, we propose a theory of motor development based on a dynamical systems perspective that is consistent with our infant studies. Finally, we explore the implications of the model for physical therapists.

  8. Caregiver-Provided Physical Therapy Home Programs for Children with Motor Delay: A Scoping Review.

    Science.gov (United States)

    Gorgon, Edward James R

    2018-06-01

    Caregiver-provided physical therapy home programs (PTHP) play an important role in enhancing motor outcomes in pediatric patient populations. This scoping review systematically mapped clinical trials of caregiver-provided PTHP that were aimed at enhancing motor outcomes in children who have or who are at risk for motor delay, with the purpose of (1) describing trial characteristics; (2) assessing methodologic quality; and (3) examining the reporting of caregiver-related components. Physiotherapy Evidence Database (PEDro), Cochrane CENTRAL, PubMed, Scopus, ScienceDirect, ProQuest Central, CINAHL, LILACS, and OTseeker were searched up to July 31, 2017. Two reviewers independently assessed study eligibility. Randomized or quasi-randomized controlled trials on PTHP administered by parents, other family members, friends, or informal caregivers to children who had or who were at risk for motor delay were included. Two reviewers independently appraised trial quality on the PEDro scale and extracted data. Twenty-four articles representing 17 individual trials were identified. Populations and interventions investigated were heterogeneous. Most of the trials had important research design limitations and methodological issues that could limit usefulness in ascertaining the effectiveness of caregiver-provided PTHP. Few (4 of 17) trials indicated involvement of caregivers in the PTHP planning, assessed how the caregivers learned from the training or instructions provided, or carried out both. Included studies were heterogeneous, and unpublished data were excluded. Although caregiver-provided PTHP are important in addressing motor outcomes in this population, there is a lack of evidence at the level of clinical trials to guide practice. More research is urgently needed to determine the effectiveness of care-giver-provided PTHP. Future studies should address the many important issues identified in this scoping review to improve the usefulness of the trial results.

  9. HAMLET treatment delays bladder cancer development.

    Science.gov (United States)

    Mossberg, Ann-Kristin; Hou, Yuchuan; Svensson, Majlis; Holmqvist, Bo; Svanborg, Catharina

    2010-04-01

    HAMLET is a protein-lipid complex that kills different types of cancer cells. Recently we observed a rapid reduction in human bladder cancer size after intravesical HAMLET treatment. In this study we evaluated the therapeutic effect of HAMLET in the mouse MB49 bladder carcinoma model. Bladder tumors were established by intravesical injection of MB49 cells into poly L-lysine treated bladders of C57BL/6 mice. Treatment groups received repeat intravesical HAMLET instillations and controls received alpha-lactalbumin or phosphate buffer. Effects of HAMLET on tumor size and putative apoptotic effects were analyzed in bladder tissue sections. Whole body imaging was used to study HAMLET distribution in tumor bearing mice compared to healthy bladder tissue. HAMLET caused a dose dependent decrease in MB49 cell viability in vitro. Five intravesical HAMLET instillations significantly decreased tumor size and delayed development in vivo compared to controls. TUNEL staining revealed selective apoptotic effects in tumor areas but not in adjacent healthy bladder tissue. On in vivo imaging Alexa-HAMLET was retained for more than 24 hours in the bladder of tumor bearing mice but not in tumor-free bladders or in tumor bearing mice that received Alexa-alpha-lactalbumin. Results show that HAMLET is active as a tumoricidal agent and suggest that topical HAMLET administration may delay bladder cancer development. Copyright (c) 2010 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

  10. [Fine motor and self-development assessment of preschool children with epilepsy].

    Science.gov (United States)

    Lendraĭtene, E B; Petrushiavichene, D P; Andronavichiute, Iu P; Vapzhaĭtite, L A; Krishchiunas, A I

    2014-01-01

    Objective. To assess fine motor and self-care skills in preschool children with epilepsy. Material and methods. The study included 22 children, 12 girls (54.5%) and 10 boys (45.5%), mean age 41.5±19.9 months. Children were tested with DISC and Munchen tests. Results and conclusion. Among preschool children with epilepsy, 50% have impaired and 22.7% - delayed development of fine motor skills. The mean coefficient of fine motor skills was 59.0±28.1. Among preschool children with epilepsy, 36.4% have impaired and 45.5% - delayed development of self-development skills. The coefficient of self-care skills was 57.8±26.1. DISC and Munchen tests for evaluation of small motor and self-care skills are equivalent for assessment in children with epilepsy (pskills were more often disturbed (pfine motor skills (p<0.05).

  11. Development of a miniature fan motor

    Science.gov (United States)

    Wang, Chien-Chang; Yao, Yeong-Der; Liang, Kun-Yi; Huang, Chung-Chun; Chang, Yu-Choung

    2012-04-01

    A novel compact axial flux fan motor was developed. Such a micromotor could be a potential candidate for using as the cooling solution for the next generation mobile devices, for example, smart phones and pico-projectors. The key parameters of the motor, such as back electromotive force, cogging torque, and axial preload are predicted using finite element method. In addition, new approaches are proposed to measure these items, and the corresponding experimental results are in good agreement with the simulated one. Moreover, the undesired vibration harmonic is successfully suppressed, and the fan motor represents a high static pressure and air flow rate.

  12. Identifying and comparing states of time-delayed systems: phase diagrams and applications to human motor control systems

    International Nuclear Information System (INIS)

    Frank, T.D.; Friedrich, R.; Beek, P.J.

    2005-01-01

    A data driven characterization of time-delayed stochastic systems is proposed in terms of linear delay differential equations and two drift parameters. It is shown how these parameters determine the states of such systems with respect to generalized phase diagrams. This approach allows for a comparison of systems with different parameters as exemplified for two motor control tasks: tracking and force production

  13. Superconducting homopolar motor and conductor development

    Science.gov (United States)

    Gubser, Donald U.

    1996-10-01

    The U.S. Navy has been developing superconducting homopolar motors for ship applications since 1969; a successful at-sea demonstration of the first motor, using NbTi wire for the magnet, was achieved in the early 1980s. Recently, this same motor was used as a test bed to demonstrate progress in high-critical-temperature superconducting magnet technology using bismuth-strontium- calcium-copper-oxide (BSCCO) compounds. In the fall of 1995, this motor achieved a performance of 124 kW operating at a temperature of 4.2 K and 91 kW while operating at 28 K. Future tests are scheduled using new magnets with conductors of both the 2223 and the 2212 BSCCO phases. This article describes the advantages of superconducting propulsion and recent progress in the development of BSCCO conductors for use in Navy power systems.

  14. Cross-cultural analysis of the motor development of Brazilian, Greek and Canadian infants assessed with the Alberta Infant Motor Scale

    Directory of Open Access Journals (Sweden)

    Raquel Saccani

    2013-09-01

    Full Text Available OBJECTIVE: To compare the motor development of infants from three population samples (Brazil, Canada and Greece, to investigate differences in the percentile curves of motor development in these samples, and to investigate the prevalence of motor delays in Brazilian children. METHODS: Observational, descriptive and cross-sectional study with 795 Brazilian infants from zero to 18 months of age, assessed by the Alberta Infant Motor Scale (AIMS at day care centers, nurseries, basic health units and at home. The Brazilian infants' motor scores were compared to the results of two population samples from Greece (424 infants and Canada (2,400 infants. Descriptive statistics was used, with one-sample t-test and binomial tests, being significant p≤0.05. RESULTS: 65.4% of Brazilian children showed typical motor development, although with lower mean scores. In the beginning of the second year of life, the differences in the motor development among Brazilian, Canadian and Greek infants were milder; at 15 months of age, the motor development became similar in the three groups. A non-linear motor development trend was observed. CONCLUSIONS: The lowest motor percentiles of the Brazilian sample emphasized the need for national norms in order to correctly categorize the infant motor development. The different ways of motor development may be a consequence of cultural differences in infant care.

  15. DO INFANTS USING BABY WALKERS SUFFER DEVELOPMENTAL DELAYS IN ACQUISITION OF MOTOR SKILLS?

    OpenAIRE

    A. Talebian; A. Honarpishe; A. Taghavi; E. Fakharian; M. Parsa; GA. Mousavi

    2008-01-01

     AbstractObjectiveDevelopment is a complex process, completed over a specific period of time, through the maturation of the nervous system. It is affected by genetic, ethnic, nutritional, social, and economic factors; one of the environmental factors affecting the acquisition of motor skills in infants is the use of baby walkers. Since this device is very commonly used for infants in our country, we conducted this study to evaluate its effects on the acquisition of motor skills in this age gr...

  16. Efeito da intervenção em esteira motorizada na aquisição da marcha independente e desenvolvimento motor em bebês de risco para atraso desenvolvimental Efecto de la intervención en caminadora automática en la adquisición de la marcha independiente y desarrollo motor en bebés de riesgo para retraso de desarrollo Treadmill training effects on walking acquisition and motor development in infants at risk of developmental delay

    Directory of Open Access Journals (Sweden)

    Diana Xavier C. Schlittler

    2011-03-01

    showed alternated walking steps on the treadmill, which increased during the intervention period (p<0,05. They also improved their global motor development compared to Risk Control Group of infants. CONCLUSIONS: Motorized treadmill intervention facilitates independent walking acquisition and improves global motor development of infants at risk of developmental delay.

  17. Motor skills development in children with inattentive versus combined subtypes of ADHD.

    Science.gov (United States)

    Vasserman, Marsha; Bender, H Allison; Macallister, William S

    2014-01-01

    The relations between attention-deficit hyperactivity disorder (ADHD) and motor skills are well documented, with research indicating both early and lifelong motor deficits in children with this disorder. Despite neuroanatomical and neurodevelopmental differences, which may predict differential rates of motor impairment between ADHD subtypes, evaluation of motor skill deficits in children with different presentations are limited in scope and equivocal in findings. The present investigation evaluated early motor development history and objectively measured motor skills in children with ADHD-Inattentive subtype (ADHD-I) and ADHD-Combined subtype (ADHD-C). One hundred and one children with ADHD-I (n = 53) and ADHD-C (n = 48) were included. Variables included Full-Scale IQ (FSIQ), history of motor delays, and utilization of early intervention services, as well as objectively measured motor impairment as assessed via tasks of fine-motor coordination. No between-group differences were found for FSIQ, but differences in age emerged, with the ADHD-I group being older. No differences in early motor delays were observed, though a considerably higher percentage of children with ADHD-C demonstrated early difficulties. Surprisingly, although children and adolescents with ADHD-C reported more frequent utilization of early intervention services, those with ADHD-I exhibited greater levels of current motor impairment on objective tasks. Given the over-representation of older children in the ADHD-I group, data were reanalyzed after excluding participants older than 10 years of age. Although the between-group differences were no longer significant, more than twice the number of parents of children with ADHD-C reported early motor delays, as compared with the ADHD-I group. Overall, children with ADHD-I were more likely to exhibit current objectively measured motor impairment, possibly due to later identification, less intervention, and/or different neurodevelopmental substrates

  18. Young Athletes program: impact on motor development.

    Science.gov (United States)

    Favazza, Paddy C; Siperstein, Gary N; Zeisel, Susan A; Odom, Samuel L; Sideris, John H; Moskowitz, Andrew L

    2013-07-01

    This study examined the effectiveness of the Young Athletes program to promote motor development in preschool-aged children with disabilities. In the study, 233 children were randomly assigned to a control group or the Young Athletes (YA) intervention group which consisted of 24 motor skill lessons delivered 3 times per week for 8 weeks. Hierarchical Linear Modeling (HLM) showed that children who participated in the YA intervention exhibited mean gains of 7-9 months on the Peabody Developmental Motor Subscales (PDMS) compared with mean gains of 3-5 months for the control group. Children in the YA intervention also exhibited significant gains on the gross motor subscale of the Vineland Teacher Rating Form (VTRF). Teachers and parents reported benefits for children not only in specific motor skills, but also kindergarten readiness skills and social/play skills. The necessity for direct and intentional instruction of motor skills, as well as the challenges of involving families in the YA program, are discussed.

  19. development of motorized development of motorized oil palm fruit

    African Journals Online (AJOL)

    eobe

    industrial activity in a number of developing West. African and ... pharmaceutical industries for the manufacture of drugs. ... production line of which oil palm fruit digestion is one. Thus, one ... For effective design of the machine, it was necessary.

  20. Environmental Factors Affecting Preschoolers' Motor Development

    Science.gov (United States)

    Venetsanou, Fotini; Kambas, Antonis

    2010-01-01

    The process of development occurs according to the pattern established by the genetic potential and also by the influence of environmental factors. The aim of the present study was to focus on the main environmental factors affecting motor development. The review of the literature revealed that family features, such as socioeconomic status,…

  1. Development of Traction Drive Motors for the Toyota Hybrid System

    Science.gov (United States)

    Kamiya, Munehiro

    Toyota Motor Corporation developed in 2005 a new hybrid system for a large SUV. This system included the new development of a high-speed traction drive motor achieving a significant increase in power weight ratio. This paper provides an overview of the hybrid system, discusses the characteristics required of a traction drive motor, and presents the technologies employed in the developed motor.

  2. Comparison of Tc-99m ECD brain SPECT between patients with delayed development and cerebral palsy

    International Nuclear Information System (INIS)

    Cho, I.; Chun, K.; Won, K.; Lee, H.; Jang, S.; Lee, J.

    2002-01-01

    Purpose: In previous study, thalamic or cerebellar hypoperfusion were reported in patients with cerebral palsy. This study was performed to evaluate cerebral perfusion abnormalities using Tc-99m ECD brain SPECT in patients with delayed motor development. Methods: Nineteen patients (9 boys, 10 girls, mean age 25.5 months) with delayed development underwent brain SPECT after injection of 185∼370 MBq of Tc-99m ECD. The imaging was obtained between 30 minutes and 1hr after injection. The patients were divided clinically as follows, patients with delayed development (n=5) and patients with cerebral palsy (n=14) who has delayed development and abnormal movement. The clinical subtypes of cerebral palsy were spastic quadriplegia (n=5), spastic diplegia (n=6) and spastic hemiplegia (n=3). In each group, decrease of cerebral perfusion was evaluated visually as mild, moderate and severe and quantitation of cerebral perfusion after Lassen's correction was also obtained. Results: SPECT findings showed normal or mildly decreased thalamic perfusion in patients with delayed development and severe decrease of thalamic or cerebellar perfusion in patients with spastic quadriplegia. In patients with spastic diplegia, mild decrease of perfusion was observed in thalamus. In quantified data, thalamic perfusion was lowest in patients with spastic quadriplegia and highest in patients with delayed development, but there were no statistically significant differences. Conclusion: Brain SPECT with Tc-99m ECD has a role in the detection of perfusion abnormalities in patients with delayed development and cerebral palsy

  3. Associations of Gross Motor Delay, Behavior, and Quality of Life in Young Children With Autism Spectrum Disorder.

    Science.gov (United States)

    Hedgecock, James B; Dannemiller, Lisa A; Shui, Amy M; Rapport, Mary Jane; Katz, Terry

    2018-04-01

    Young children with autism spectrum disorder (ASD) often have gross motor delays that may accentuate problem daytime behavior and health-related quality of life (QoL). The objective of this study was to describe the degree of gross motor delays in young children with ASD and associations of gross motor delays with problem daytime behavior and QoL. The primary hypothesis was that Gross motor delays significantly modifies the associations between internalizing or externalizing problem daytime behavior and QoL. This study used a cross-sectional, retrospective analysis. Data from 3253 children who were 2 to 6 years old and who had ASD were obtained from the Autism Speaks Autism Treatment Network and analyzed using unadjusted and adjusted linear regression. Measures included the Vineland Adaptive Behavior Scales, 2nd edition, gross motor v-scale score (VABS-GM) (for Gross motor delays), the Child Behavior Checklist (CBCL) (for Problem daytime behavior), and the Pediatric Quality of Life Inventory (PedsQL) (for QoL). The mean VABS-GM was 12.12 (SD = 2.2), representing performance at or below the 16th percentile. After adjustment for covariates, the internalizing CBCL t score decreased with increasing VABS-GM (β = - 0.64 SE = 0.12). Total and subscale PedsQL scores increased with increasing VABS-GM (for total score: β = 1.79 SE = 0.17; for subscale score: β = 0.9-2.66 SE = 0.17-0.25). CBCL internalizing and externalizing t scores decreased with increasing PedsQL total score (β = - 0.39 SE = 0.01; β = - 0.36 SE = 0.01). The associations between CBCL internalizing or externalizing t scores and PedsQL were significantly modified by VABSGM (β = - 0.026 SE = 0.005]; β = - 0.019 SE = 0.007). The study lacked ethnic and socioeconomic diversity. Measures were collected via parent report without accompanying clinical assessment. Cross motor delay was independently associated with Problem daytime behavior and QoL in children with ASD. Gross

  4. Superconducting coil development and motor demonstration: Overview

    Science.gov (United States)

    Gubser, D. U.

    1995-12-01

    Superconducting bismuth-cuprate wires, coils, and magnets are being produced by industry as part of a program to test the viability of using such magnets in Naval systems. Tests of prototype magnets, coils, and wires reveal progress in commercially produced products. The larger magnets will be installed in an existing superconducting homopolar motor and operated initially at 4.2K to test the performance. It is anticipated that approximately 400 Hp will be achieved by the motor. This article reports on the initial tests of the magnets, coils, and wires as well as the development program to improve their performance.

  5. Neuromodulation during motor development and behavior.

    Science.gov (United States)

    Pflüger, H J

    1999-12-01

    Important recent advances have been made in understanding the role of aminergic modulation during the maturation of Xenopus larvae swimming rhythms, including effects on particular ion channel types of component neurons, and the role of peptidergic modulation during development of adult central patterns generators in the stomatogastric ganglion of crustaceans. By recording from octopaminergic neuromodulatory neurons during ongoing motor behavior in the locust, new insights into the role of this peripheral neuromodulatory mechanism have been gained. In particular, it is now clear that the octopaminergic neuromodulatory system is automatically activated in parallel to the motor systems, and that both excitation and inhibition play important functional roles.

  6. DEVELOPMENT OF FINE MOTOR COORDINATION AND VISUAL-MOTOR INTEGRATION IN PRESCHOOL CHILDREN

    OpenAIRE

    MEMISEVIC Haris; HADZIC Selmir

    2015-01-01

    Fine motor skills are prerequisite for many everyday activities and they are a good predictor of a child's later academic outcome. The goal of the present study was to assess the effects of age on the development of fine motor coordination and visual-motor integration in preschool children. The sample for this study consisted of 276 preschool children from Canton Sara­jevo, Bosnia and Herzegovina. We assessed children's motor skills with Beery Visual Motor Integration Test and Lafayette Pegbo...

  7. Development of fine motor skills in preterm infants

    NARCIS (Netherlands)

    Bos, Arend F.; Van Braeckel, Koenraad N. J. A.; Hitzert, Marrit M.; Tanis, Jozien C.; Roze, Elise

    2013-01-01

    Fine motor skills are related to functioning in daily life and at school. We reviewed the status of knowledge, in preterm children, on the development of fine motor skills, the relation with gross motor skills, and risk factors for impaired fine motor skills. We searched the past 15 years in PubMed,

  8. Development of a Motorized Digital Cone Penetrometer

    OpenAIRE

    Chung, Sun–Ok; Cho, Jin–Woong; Yamakawa, Takeo; 山川, 武夫

    2012-01-01

    Quantification and management of variability in soil strength, or soil compaction, is an important issue in countries such as Korea and Japan where typical field sizes are small, but tractor mounted on–the–go sensors that have been developed in USA and European countries are not practical. Therefore, hand–operated digital penetrometers have been widely used in Asian countries, but maintaining standard penetration rate and angle would be difficult. In this study, a motorized digital cone penet...

  9. Delayed cerebral development in twins with congenital hyperthyroidism.

    Science.gov (United States)

    Kopelman, A E

    1983-09-01

    Twins had congenital hyperthyroidism and delayed cerebral development manifested as ventriculomegaly, increased space in the interhemispheric fissure, and an exaggerated gyral pattern on cranial computed tomographic scans. At 3 1/2 years of age, both children had delayed development. Fetal and neonatal hyperthyroidism may interfere with normal brain growth and maturation with both neuranatomic and developmental sequelae.

  10. Sociocultural predictors of motor development of athletes from ...

    African Journals Online (AJOL)

    Sociocultural predictors of motor development of athletes from Botswana, Lesotho and Swaziland. ... variables as they influenced the athletes' motor skill development. The social situations, family and the schools were found to significantly ...

  11. Auditory-Motor Interactions in Pediatric Motor Speech Disorders: Neurocomputational Modeling of Disordered Development

    NARCIS (Netherlands)

    Terband, H.R.; Maassen, B.A.M.; Guenther, F.H.; Brumberg, J.

    2014-01-01

    Background/Purpose: Differentiating the symptom complex due to phonological-level disorders, speech delay and pediatric motor speech disorders is a controversial issue in the field of pediatric speech and language pathology. The present study investigated the developmental interaction between

  12. Auditory-motor interactions in pediatric motor speech disorders: Neurocomputational modeling of disordered development

    NARCIS (Netherlands)

    Terband, H.; Maassen, B.; Guenther, F. H.; Brumberg, J.

    2014-01-01

    BACKGROUND/PURPOSE: Differentiating the symptom complex due to phonological-level disorders, speech delay and pediatric motor speech disorders is a controversial issue in the field of pediatric speech and language pathology. The present study investigated the developmental interaction between

  13. Minimum Competencies in Undergraduate Motor Development. Guidance Document

    Science.gov (United States)

    National Association for Sport and Physical Education, 2004

    2004-01-01

    The minimum competency guidelines in Motor Development described herein at the undergraduate level may be gained in one or more motor development course(s) or through other courses provided in an undergraduate curriculum. The minimum guidelines include: (1) Formulation of a developmental perspective; (2) Knowledge of changes in motor behavior…

  14. Anthropometric and motor development profiles of street children ...

    African Journals Online (AJOL)

    With regard to the gross motor development, deficits were found with regard to running speed and agility, bilateral coordination and strength. Fine motor deficits were found in upper limb speed and dexterity, response speed and visual motor control. The neuromotor development of street children also showed deficits, ...

  15. Associations of motor co-ordination and attention with motor-perceptual development in 3-year-old preterm and full-term children who needed neonatal intensive care.

    Science.gov (United States)

    Hemgren, E; Persson, K

    2007-01-01

    Children who have needed neonatal intensive care (NIC) are considered to be at risk for deficits such as developmental co-ordination disorder and attention-deficit/hyperactivity disorder. By assessing motor-perceptual development, motor co-ordination and attention already at 3 years of age, it might be possible to identify such deficits earlier than they are today. To investigate the motor-perceptual development in a group of 202 NIC children but had no major impairments, to describe associations of deficits in co-ordination and attention with motor-perceptual delays, and to estimate the prevalence of NIC children with combined deficits together with a motor-perceptual delay. Co-ordination and attention in children born very preterm (n = 57), moderately preterm (n = 75) and full-term (n = 70) were observed according to a model for Combined Assessment of Motor Performance and Behaviour while they were assessed using a developmental scale, Motor-Perceptual Development, 0-7 years, MPU. In two out of 14 MPU areas, a larger proportion of very preterm than of moderately preterm and full-term children had marked developmental delay. Overall, the proportion of NIC children having a motor-perceptual delay increased with increasing incoordination and especially increasing lack of attention. Twenty-one (11%) of the NIC children had different motor-perceptual delays combined with pronounced incoordination and pronounced lack of attention. Deficits in co-ordination and attention were associated with motor-perceptual delays in areas important for daily living and development of academic skills. Therefore, to find children at risk for developmental co-ordination disorder and attention-deficit/hyperactivity disorder, assessments of co-ordination and attention should be added to assessments of motor-perceptual development in 3-year-old NIC children.

  16. Transition from Target to Gaze Coding in Primate Frontal Eye Field during Memory Delay and Memory–Motor Transformation123

    Science.gov (United States)

    Sajad, Amirsaman; Sadeh, Morteza; Yan, Xiaogang; Wang, Hongying

    2016-01-01

    Abstract The frontal eye fields (FEFs) participate in both working memory and sensorimotor transformations for saccades, but their role in integrating these functions through time remains unclear. Here, we tracked FEF spatial codes through time using a novel analytic method applied to the classic memory-delay saccade task. Three-dimensional recordings of head-unrestrained gaze shifts were made in two monkeys trained to make gaze shifts toward briefly flashed targets after a variable delay (450-1500 ms). A preliminary analysis of visual and motor response fields in 74 FEF neurons eliminated most potential models for spatial coding at the neuron population level, as in our previous study (Sajad et al., 2015). We then focused on the spatiotemporal transition from an eye-centered target code (T; preferred in the visual response) to an eye-centered intended gaze position code (G; preferred in the movement response) during the memory delay interval. We treated neural population codes as a continuous spatiotemporal variable by dividing the space spanning T and G into intermediate T–G models and dividing the task into discrete steps through time. We found that FEF delay activity, especially in visuomovement cells, progressively transitions from T through intermediate T–G codes that approach, but do not reach, G. This was followed by a final discrete transition from these intermediate T–G delay codes to a “pure” G code in movement cells without delay activity. These results demonstrate that FEF activity undergoes a series of sensory–memory–motor transformations, including a dynamically evolving spatial memory signal and an imperfect memory-to-motor transformation. PMID:27092335

  17. Parenting Practices and Associations with Development Delays among Young Children in Dominican Republic.

    Science.gov (United States)

    Uwemedimo, Omolara Thomas; Howlader, Afrin; Pierret, Giselina

    According to the World Health Organization, >200 million children in low- and middle-income countries experience developmental delays. However, household structure and parenting practices have been minimally explored as potential correlates of developmental delay in low- and middle-income countries, despite potential as areas for intervention. The objective of the study was to examine associations of developmental delays with use of World Health Organization-recommended parenting practices among a clinic-based cohort of children aged 6-60 months attending in La Romana, Dominican Republic. This study was conducted among 74 caregiver-child pairs attending the growth-monitoring clinic at Hospital Francisco Gonzalvo in June 2015. The Malawi Developmental Assessment Tool was adapted and performed on each child to assess socioadaptive, fine motor, gross motor, and language development. The IMCI Household Level Survey Questionnaire was used to assess parenting practices. Fisher's exact test was used to determine associations significant at P children had a delay in at least 1 developmental domain. Most caregivers used scolding (43.2%) or spanking (44%) for child discipline. Children who were disciplined by spanking and scolding were more likely to have language delay (P = .007) and socioadaptive delay (P = .077), respectively. On regression analysis, children with younger primary caregivers had 7 times higher odds of language delay (adjusted odds ratio [AOR]: 7.35, 95% confidence interval [CI]: 1.52-35.61) and 4 times greater odds of any delay (AOR: 4.72, 95% CI: 1.01-22.22). In addition, children punished by spanking had 5 times higher odds of having language delay (AOR: 5.04, 95% CI: 1.13-22.39). Parenting practices such as harsh punishment and lack of positive parental reinforcement were found to have strong associations with language and socioadaptive delays. Likewise, delays were also more common among children with younger caregivers. Copyright © 2017 Icahn

  18. Development of a statistically based access delay timeline methodology.

    Energy Technology Data Exchange (ETDEWEB)

    Rivera, W. Gary; Robinson, David Gerald; Wyss, Gregory Dane; Hendrickson, Stacey M. Langfitt

    2013-02-01

    The charter for adversarial delay is to hinder access to critical resources through the use of physical systems increasing an adversarys task time. The traditional method for characterizing access delay has been a simple model focused on accumulating times required to complete each task with little regard to uncertainty, complexity, or decreased efficiency associated with multiple sequential tasks or stress. The delay associated with any given barrier or path is further discounted to worst-case, and often unrealistic, times based on a high-level adversary, resulting in a highly conservative calculation of total delay. This leads to delay systems that require significant funding and personnel resources in order to defend against the assumed threat, which for many sites and applications becomes cost prohibitive. A new methodology has been developed that considers the uncertainties inherent in the problem to develop a realistic timeline distribution for a given adversary path. This new methodology incorporates advanced Bayesian statistical theory and methodologies, taking into account small sample size, expert judgment, human factors and threat uncertainty. The result is an algorithm that can calculate a probability distribution function of delay times directly related to system risk. Through further analysis, the access delay analyst or end user can use the results in making informed decisions while weighing benefits against risks, ultimately resulting in greater system effectiveness with lower cost.

  19. Recent developments in esophageal motor disorders.

    Science.gov (United States)

    Beaumont, Hanneke; Boeckxstaens, Guy

    2007-07-01

    Every year more insight into the pathogenesis and treatment of esophageal motor disorders is obtained. This review highlights some interesting literature published in this area during the last year. Longitudinal and circular muscle contractions act in a well coordinated fashion to allow normal peristalsis. Techniques such as intraluminal impedance, high-resolution manometry and intraluminal ultrasound provide useful additional information on esophageal function both in the normal and abnormal situation. The dynamics of the gastroesophageal junction can be studied with a newly developed probe, and the mechanism behind transient lower esophageal sphincter relaxations is still being unravelled. New manometric criteria for nutcracker esophagus have been proposed, whereas further evidence is reported supporting an association between diabetes mellitus and cardiovascular disease and esophageal dysmotility and spasm, respectively. Finally, several long-term follow-up results of surgical myotomy and pneumodilatation have been reported. Due to the perfection of esophageal measuring techniques, our knowledge of esophageal function continues to increase. The studies reviewed here provide interesting information on the pathogenesis and treatment of several esophageal motor disorders.

  20. Studies in Motor Behavior: 75 Years of Research in Motor Development, Learning, and Control

    Science.gov (United States)

    Ulrich, Beverly D.; Reeve, T. Gilmour

    2005-01-01

    Research focused on human motor development, learning, and control has been a prominent feature in the Research Quarterly for Exercise and Sport (RQES) since it was first published in 1930. The purpose of this article is to provide an overview of the papers in the RQES that demonstrate the journal's contributions to the study of motor development,…

  1. Aspectos motores corporais e orais em um grupo de crianças com transtorno/atraso fonológico Body and oral motor aspects in a group of children with phonological delay/disorder

    Directory of Open Access Journals (Sweden)

    Ana Paula Ramos de Souza

    2010-01-01

    Full Text Available OBJETIVO: Comparar o desenvolvimento motor e aspectos orofaciais em crianças com transtorno e atraso fonológico. MÉTODOS: Participaram da pesquisa 80 crianças de cinco a 11 anos de idade pertencentes à rede escolar regular de um município da Grande Porto Alegre com alterações fonológicas. Foi realizada uma entrevista com os pais através de um questionário semi-estruturado. Em seguida, foram avaliados o sistema estomatognático e a fala das crianças, e o diagnóstico de transtorno ou atraso fonológico foi confirmado para cada sujeito. Para a análise estatística, foram utilizados os testes de Fisher e o Qui-quadrado com nível de significância de 5% (pPURPOSE: To compare the motor development and orofacial aspects in children with phonological disorder and delay. METHODS: The participants were 80 children with phonological deficits and ages ranging from five to 11 years, who belonged to the regular school system of a city in Rio Grande do Sul, Brazil. An interview with their parents was conducted, using a semi-structured questionnaire. After that, it was carried out the assessment of the subjects' stomatognathic system and speech, and the diagnosis of phonological delay or disorder was confirmed. The Chi-square test and the Fisher test were used for statistical analysis, with significance level of 5% (p<0,05. RESULTS: There were no statistically significant differences between the group with phonological delay and the group with phonological disorder in all aspects examined. CONCLUSION: Phonological delay and disorder do not show significant distinction regarding motor, oral and infectious aspects, together with deleterious oral habits, as shown by the homogeneity between the groups.

  2. The value of delay in tidal energy development

    International Nuclear Information System (INIS)

    MacDougall, Shelley L.

    2015-01-01

    Despite robust research, prototype development and demonstration of in-stream tidal energy devices, progress to the commercialization stage has been slow. Some of this can be attributed to a lack readiness or financing. However, when uncertainty is high, a developer may choose to delay a project until more is known. The option to delay has value for a company. This study applies the real option valuation model to an investment in a 10 MW array of in-stream tidal energy conversion devices at the Fundy Ocean Research Centre for Energy (FORCE) in the Bay of Fundy, Nova Scotia, Canada. The values of investing and the option to delay are calculated. A sensitivity analysis of key drivers and scenarios with various input values to the option model are constructed to observe the impact on the 'invest versus delay' decision. The analysis suggests there is value in owning the option to develop, by leasing a FORCE berth, but waiting while uncertainty is resolved. Implications for policy-setting are discussed. - Highlights: • Analyze an invest-vs-delay decision in tidal energy conversion using real options. • Assess whether conditions are conducive to an economically rational decision to delay. • Identify aspects of the decision that can be influenced by government policy.

  3. The role of older siblings in infant motor development.

    Science.gov (United States)

    Leonard, Hayley C; Hill, Elisabeth L

    2016-12-01

    Previous research has suggested that infant motor skills may be affected by older siblings but has not considered whether this is due to specific characteristics of the older sibling or of the quality of the sibling relationship. The current study used a longitudinal diary method to record infant motor milestones from 23 infants with older siblings along with parent reports and standardized assessments of motor skills. Parent reports of the older siblings' motor skills and the sibling relationship were also collected until the infants were 18months old. The motor skills, age, and sex of the older siblings were not significantly related to any measure of infant motor development. A significant correlation was revealed between perceived agonism between siblings and infant fine motor skills at 18months, suggesting the importance of considering reciprocal effects of motor development on sibling relationships. Overall, the suggestion that older siblings may provide a good model of motor skills for infants is not supported by the current data. In the future, it will be important to assess the dynamic interactions between different factors in predicting infant motor development, allowing early identification of motor difficulties, which could affect other areas of cognitive development and health. Copyright © 2016 Elsevier Inc. All rights reserved.

  4. Programmable dc motor controller

    Science.gov (United States)

    Hopwood, J. E.

    1982-11-01

    A portable programmable dc motor controller, with features not available on commercial instruments was developed for controlling fixtures during welding processes. The controller can be used to drive any dc motor having tachometer feedback and motor requirements not exceeding 30 volts, 3 amperes. Among the controller's features are delayed start time, upslope time, speed, and downslope time.

  5. Timing of motor milestones achievement and development of overweight in childhood

    DEFF Research Database (Denmark)

    Morgen, Camilla Schmidt; Andersen, Anne-Marie Nybo; Due, P

    2014-01-01

    WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT: The risk of childhood obesity is influenced by a number of pre- and post-natal factors. The risk of childhood obesity is correlated with body weight during infancy, which might be related to the psychomotor development of the child. The previous literature...... on motor milestones and childhood overweight is limited and results are inconsistent. WHAT THIS STUDY ADDS: Weight status in early life and timing of achievement of gross motor milestones (the ability to sit and walk) are largely independent of each other. Timing of achievement of motor milestones in early...... life does not predict overweight or increased BMI later in childhood. BACKGROUND: Overweight may hinder achievement of gross motor milestones and delayed achievement of milestones may increase the risk of later overweight for reasons involving physical activity and the building of lean body mass...

  6. Functional recovery of regenerating motor axons is delayed in mice heterozygously deficient for the myelin protein P(0) gene

    DEFF Research Database (Denmark)

    Rosberg, Mette Romer; Alvarez, Susana; Krarup, Christian

    2013-01-01

    Mice with a heterozygous knock-out of the myelin protein P0 gene (P0+/-) develop a neuropathy similar to human Charcot-Marie-Tooth disease. They are indistinguishable from wild-types (WT) at birth and develop a slowly progressing demyelinating neuropathy. The aim of this study was to investigate...... whether the regeneration capacity of early symptomatic P0+/- is impaired as compared to age matched WT. Right sciatic nerves were lesioned at the thigh in 7-8 months old mice. Tibial motor axons at ankle were investigated by conventional motor conduction studies and axon excitability studies using...... threshold tracking. To evaluate regeneration we monitored the recovery of motor function after crush, and then compared the fiber distribution by histology. The overall motor performance was investigated using Rotor-Rod. P0+/- had reduced compound motor action potential amplitudes and thinner myelinated...

  7. Analysis of an intervention directed to the development of balance and gross and fine motor coordination

    Directory of Open Access Journals (Sweden)

    Letícia Carrillo Maronesi

    2015-07-01

    Full Text Available Introduction: Children’s motor skills evolve according to age and the continuing influence of intrinsic and extrinsic factors that cause variations from one child to another; this makes the course of development unique in each child. Objective: To develop an intervention for a child with delays in fine motor coordination, gross motor coordination and balance and analyze its impact on the child’s development. Methods: Pre- and post-test quasi-experimental design. The instrument used was the Motor Development Scale applied to a 4 year old child. An intervention plan was developed based on the results obtained throught the tests. The plan consists of activities designed to stimulate the aforementioned acquisitions. The implementation of the intervention plan lasted two months. The child was tested at the beginning and at the end of the intervention to determine whether there was gain in the stimulated acquisitions. The JT method was adopted for data analysis and verification of occurrence of reliable and clinically relevant positive changes. Results: The results of this study demonstrate that reliable positive changes occurred with respect to the psychomotor items that underwent stimulation. Conclusion: It is possible to infer that this intervention had a positive effect on the child’s development . Hence, this study contributes to improve the care provided to children with delayed psychomotor development, illustrating possibilities of strategies and activities. It also allows the recognition of the action of occupational therapists as one of the professionals who compose the multidisciplinary team focused on early intervention.

  8. Young Athletes: A Special Olympics Motor Skill Development Program

    Science.gov (United States)

    Favazza, Paddy C.; Siperstein, Gary N.

    2013-01-01

    While motor skills develop naturally among most typically developing preschoolers, young children with disabilities often experience deficits in this area. Therefore, it is important that children with disabilities are provided with "direct and intentional instruction" for motor skill development during the preschool years. One program…

  9. Fine motor skills development of children with autism sepctrum disorder.

    OpenAIRE

    Marešová, Petra

    2010-01-01

    My diploma thesis topic is Fine motor skills development of children with autism spectrum disorder. The objective of this document is to create a well arranged group of exercises and structured tasks aimed to develop fine motor skills of children at pre-school age with autism spectrum disorder. Theoretical part of this diploma thesis contains basic information related to autism and various details about motor skills. Practical section describes individual jobs and structured tasks used for fi...

  10. Does Motor Development in Infancy Predict Spinal Pain in Later Childhood?

    DEFF Research Database (Denmark)

    Kamper, Steven J; Williams, Christopher M; Hestbaek, Lise

    2017-01-01

    Study Design Longitudinal cohort study. Background Spinal pain is responsible for a huge personal and societal burden but the aetiology remains unclear. Deficits in motor control have been implicated with spinal pain in adults, and delayed motor development is associated with a range of health...... a child first sits or walks without support does not influence the likelihood that they will experience spinal pain in later childhood. Level of Evidence Etiology 2b. J Orthop Sports Phys Ther, Epub 15 Sep 2017. doi:10.2519/jospt.2017.7484....

  11. Development of fine motor skills in preterm infants.

    Science.gov (United States)

    Bos, Arend F; Van Braeckel, Koenraad N J A; Hitzert, Marrit M; Tanis, Jozien C; Roze, Elise

    2013-11-01

    Fine motor skills are related to functioning in daily life and at school. We reviewed the status of knowledge, in preterm children, on the development of fine motor skills, the relation with gross motor skills, and risk factors for impaired fine motor skills. We searched the past 15 years in PubMed, using ['motor skills' or 'fine motor function' and 'preterm infant'] as the search string. Impaired gross and fine motor skills are among the most frequently occurring problems encountered by preterm children who do not develop cerebral palsy. The prevalence is around 40% for mild to moderate impairment and 20% for moderate impairment. Fine motor skill scores on the Movement Assessment Battery for Children are about 0.62 of a standard deviation lower compared with term children. Risk factors for fine motor impairments include moderately preterm birth (odds ratio [OR] 2.0) and, among very preterm children (development of and recovery from brain injury could guide future intervention attempts aimed at improving fine motor skills of preterm children. © The Authors. Developmental Medicine & Child Neurology © 2013 Mac Keith Press.

  12. Motor Importance of motor assessment in school children: analysis of the reliability of the motor development scale

    Directory of Open Access Journals (Sweden)

    Kassandra Nunes Amaro

    2010-09-01

    Full Text Available The objective of this study was to investigate the motor performance of school chil-dren aged 6 to 10 years without learning difficulties (n=101, and to analyze the reliability of the Motor Development Scale (MDS (Rosa Neto, 2002. Descriptive statistics with calculation of the mean, standard deviation, and range was used for data analysis. The internal consistency of the MDS was assessed using Cronbach’s alpha coefficient, and the correlation between variables was determined by Pearson’s linear correlation, with p<0.05. The results showed (1 that motor development was within normal limits in 96% of the children, and (2 a high correlation betwe-en chronological age and general motor age, indicating good internal consistency. These data demonstrate the logic and structured design of the MDS, confirming its reliability.

  13. Delayed speech development in children: Introduction to terminology

    Directory of Open Access Journals (Sweden)

    M. Yu. Bobylova

    2017-01-01

    Full Text Available There has been recently an increase in the number of children diagnosed with delayed speech development. There is delay compensation with age, but mild deficiency often remains for life. Delayed speech development is more common in boys than in girls. Its etiology is unknown in most cases, so a child should be followed up to make an accurate diagnosis. Genetic predisposition or environmental factors frequently influence speech development. The course of its delays is various. In the history of a number of disorders (childhood disintegrative disorder, Landau–Kleffner syndrome, there is evidence for the normal development of speech to a certain period and then stops or even regresses. By way of comparison, there are generally speech developmental changes in autism even during the preverbal stage (a complex of revival fails to form; babbling is poor, low emotional, gibberish; at the same time, the baby recipes whole phrases without using them to communicate. These speech disorders are considered not only as a delay, but also as a developmental abnormality. Speech disorders in children should be diagnosed as early as possible in order to initiative corrective measures in time. In this case, a physician makes a diagnosis and a special education teacher does corrective work. The successful collaboration and mutual understanding of the specialists in these areas will determine quality of life for a child in the future. This paper focusses on the terminology and classification of delays, which are necessary for physicians and teachers to speak the same language.

  14. Zebrafish embryos exposed to alcohol undergo abnormal development of motor neurons and muscle fibers.

    Science.gov (United States)

    Sylvain, Nicole J; Brewster, Daniel L; Ali, Declan W

    2010-01-01

    Children exposed to alcohol in utero have significantly delayed gross and fine motor skills, as well as deficiencies in reflex development. The reasons that underlie the motor deficits caused by ethanol (EtOH) exposure remain to be fully elucidated. The present study was undertaken to investigate the effects of embryonic alcohol exposure (1.5%, 2% and 2.5% EtOH) on motor neuron and muscle fiber morphology in 3 days post fertilization (dpf) larval zebrafish. EtOH treated fish exhibited morphological deformities and fewer bouts of swimming in response to touch, compared with untreated fish. Immunolabelling with anti-acetylated tubulin indicated that fish exposed to 2.5% EtOH had significantly higher rates of motor neuron axon defects. Immunolabelling of primary and secondary motor neurons, using znp-1 and zn-8, revealed that fish exposed to 2% and 2.5% EtOH exhibited significantly higher rates of primary and secondary motor neuron axon defects compared to controls. Examination of red and white muscle fibers revealed that fish exposed to EtOH had significantly smaller fibers compared with controls. These findings indicate that motor neuron and muscle fiber morphology is affected by early alcohol exposure in zebrafish embryos, and that this may be related to deficits in locomotion. Copyright 2010 Elsevier Inc. All rights reserved.

  15. NEW VECTORS OF THE MOTOR INSURANCE DEVELOPMENT IN UKRAINE

    Directory of Open Access Journals (Sweden)

    N. Prikazyuk

    2015-04-01

    Full Text Available The essence and features of different forms of motor insurance are studied. As investigated, the motor insurance is one of the most popular types of insurance in many countries, and continues its further quality development. It is stated that the following new vectors of development has been recently observed in developed countries: Internet sales are getting significantly prevalent along with the traditional channels of insurance distribution; insurers’ websites provide a wide range of online features in motor insurance; innovations in motor insurance based on the use of telematics, particularly the usage-based insurance, are widely spread. Basic types of motor insurance, which represent the domestic market, are analyzed. It was found that the share of motor insurance in the insurance market of Ukraine is significant. As established, the proportion of net premiums of motor insurance is decreasing, because its development is significantly influenced by economic factors. Measures, applied by insurance companies in the domestic market of motor insurance to attract new customers and retain the existing ones, are defined. In particular, insurers are trying to develop the implementation of insurance services online, and use possibilities offered by mobile technologies. It was found that the domestic market of motor insurance is characterized by a high level of fraud, that is why some innovative measures in the domestic and international motor insurance agreements are taken to decrease it, such as the introduction of mandatory registration of insurance agents, who have the right to perform mediatory activity in compulsory civil liability insurance of owners of motor vehicles (CCLIOMV, and procedures for contracting the international insurance “Green Card” agreements with simultaneous entering the information on concluded agreement into a unified centralized database of Motor (transport insurance bureau of Ukraine using the “Green Card online

  16. Relations between Playing Activities and Fine Motor Development

    Science.gov (United States)

    Suggate, Sebastian; Stoeger, Heidrun; Pufke, Eva

    2017-01-01

    Children's fine motor skills (FMS) are being increasingly recognized as an important aspect of preschool development; yet, we know very little about the experiences that foster their development. We utilized a parent-administered children's fine and gross motor activities questionnaire (MAQ) to investigate links with FMS. We recruited a sample of…

  17. Helping Preschoolers Prepare for Writing: Developing Fine Motor Skills

    Science.gov (United States)

    Huffman, J. Michelle; Fortenberry, Callie

    2011-01-01

    Early childhood is the most intensive period for the development of physical skills. Writing progress depends largely on the development of fine motor skills involving small muscle movements of the hand. Young children need to participate in a variety of developmentally appropriate activities intentionally designed to promote fine motor control.…

  18. Motor development profile in 9-11 year-old children from the municipal education system of Maceio, Alagoas State, presenting low school performance

    Directory of Open Access Journals (Sweden)

    Maria Natália Santos da Silva

    2014-04-01

    Full Text Available Introduction: Children may present motor development delays that can influence their learning process, hence the need for specific assessment for the early detection of such delays in an attempt to resolve or mitigate possible future damage. Objective: Profile of motor development in children aged 9-11 years old presenting low academic achievement in the municipal education system of Maceio, Alagoas state. Methodology: An exploratory, descriptive, transversal study which uses the Motor Development Scale (MDS to analyze the main components of performance. Evaluations were carried out with 43 children of both genders. Results: The children assessed presented motor profiles ranging from “normal” to “far below average”, corroborating the findings in the literature. Conclusions: The results obtained are in agreement with the literature, showing a close relation between motor development and low school performance, emphasizing the importance of psychomotor intervention for the maturation of more complex motor patterns.

  19. Output Feedback Adaptive Dynamic Surface Control of Permanent Magnet Synchronous Motor with Uncertain Time Delays via RBFNN

    Directory of Open Access Journals (Sweden)

    Shaohua Luo

    2014-01-01

    Full Text Available This paper focuses on an adaptive dynamic surface control based on the Radial Basis Function Neural Network for a fourth-order permanent magnet synchronous motor system wherein the unknown parameters, disturbances, chaos, and uncertain time delays are presented. Neural Network systems are used to approximate the nonlinearities and an adaptive law is employed to estimate accurate parameters. Then, a simple and effective controller has been obtained by introducing dynamic surface control technique on the basis of first-order filters. Asymptotically tracking stability in the sense of uniformly ultimate boundedness is achieved in a short time. Finally, the performance of the proposed control has been illustrated through simulation results.

  20. ASPECTS OF MOTOR DEVELOPMENT IN CHILDREN WITH CEREBRAL PALSY

    Directory of Open Access Journals (Sweden)

    Erna Žgur

    2017-01-01

    Full Text Available Child’s motor development is not an isolated process but it rather involves numerous other developmental aspects, such as cognitive and conative. The research is focused on defining the developmental principles of motor abilities and skills in children with prominent motor deficits who were diagnosed with cerebral palsy (CP. The research compares the motor maturity between two groups of children with CP; the younger group (up to 10 years of age and the older group (10 – 16 years of age. The research included 78 primary school children with different forms of CP (diplegia, hemiplegia, mixed forms, aged between 6 and 16. The discriminant analysis used in the research showed that there is a statistically significant relationship between age and motor maturity in children with CP. The structural matrix confirmed the different hierarchical representation of the motor components (strength, coordination, precision and graphomotor skills for the selected motor model, in relation to children’s age. The function of explosive strength showed significant differences between younger and older children as regards their motor maturity. We can conclude that there is a significant developmental difference between the groups of younger and older children with CP, in relation to their motor maturity (different hierarchical representation, with the most obvious difference in motor ability of explosive strength.

  1. Mnemonic abilities of primary school children with delayed mental development.

    Directory of Open Access Journals (Sweden)

    Murafa S.V.

    2015-07-01

    Full Text Available This paper presents the results of research regarding the mnemonic abilities of primary school children with developmental delays. Empirical studies of impaired mental development offer an opportunity to elucidate the psychological mechanisms underlying the process of normal development and enable us to consider at a micro level the formation of mental processes in ontogeny, which would, under normal conditions, be nondescript and not always amenable to psychological analysis. The research addresses an experimental investigation of productivity and qualitative characteristics of mnemonic abilities among primary school students with developmental delays. V.D. Shadrikov’s Theory of Abilities, developed in a systemic approach framework, is the theoretical basis of the research. The method of deploying a memorization activity, as elaborated by V.D. Shadrikov and L.V. Cheremoshkina, was the investigation tool used. The sample included students in grades 1 to 4 between ages 7 to 12 and included a total of 100 children (66 boys and 34 girls. The control group of primary school students with typical development included 105 children (50 boys and 55 girls. The research consisted of several stages: a pilot study, experimental research (the test task was to memorize card #1; the basic task was to memorize cards #2 and #3; to reproduce cards #2 and #3; and to poll the students, mathematical data processing, and a description of the levels of mnemonic ability development among primary students with developmental delays. The following procedures were employed during statistical analysis: Spearman r3, Mann-Whitney U-test, Jonckheere-Terpstra test, and Kruskal-Wallis test. The structure of mnemonic abilities in primary schoolchildren with developmental delays was determined to vary according to the underdevelopment of their operational mechanisms. For example, memory functions are based on the use of inborn mechanisms, and a portion of children differ in the

  2. Delayed Development of Pneumothorax After Pulmonary Radiofrequency Ablation

    International Nuclear Information System (INIS)

    Clasen, Stephan; Kettenbach, Joachim; Kosan, Bora; Aebert, Hermann; Schernthaner, Melanie; Kroeber, Stefan-Martin; Boemches, Andrea; Claussen, Claus D.; Pereira, Philippe L.

    2009-01-01

    Acute pneumothorax is a frequent complication after percutaneous pulmonary radiofrequency (RF) ablation. In this study we present three cases showing delayed development of pneumothorax after pulmonary RF ablation in 34 patients. Our purpose is to draw attention to this delayed complication and to propose a possible approach to avoid this major complication. These three cases occurred subsequent to 44 CT-guided pulmonary RF ablation procedures (6.8%) using either internally cooled or multitined expandable RF electrodes. In two patients, the pneumothorax, being initially absent at the end of the intervention, developed without symptoms. One of these patients required chest drain placement 32 h after RF ablation, and in the second patient therapy remained conservative. In the third patient, a slight pneumothorax at the end of the intervention gradually increased and led into tension pneumothorax 5 days after ablation procedure. Underlying bronchopleural fistula along the coagulated former electrode track was diagnosed in two patients. In conclusion, delayed development of pneumothorax after pulmonary RF ablation can occur and is probably due to underlying bronchopleural fistula, potentially leading to tension pneumothorax. Patients and interventionalists should be prepared for delayed onset of this complication, and extensive track ablation following pulmonary RF ablation should be avoided.

  3. MOTOR STRUCTURE AND BASIC MOVEMENT COMPETENCES IN EARLY CHILD DEVELOPMENT

    Directory of Open Access Journals (Sweden)

    Rado Pišot

    2010-12-01

    Full Text Available Motor development consists of dynamic and continuous development in motor behaviour and is reflected in motor competences (on the locomotive, manipulative and postural level and motor abilities (coordination, strength, speed, balance, flexibility, precision and endurance. This is a complex process in which a child acquires motor abilities and knowledge in interaction with inherited and environmental factors. A sample of 603 boys and girls, of which 263 were aged five (age deviation +/- 3 days; 18,5 ± 3,1kg body weight; 109,4 ± 4,3 cm body height and 340 were aged six and a half (age deviation +/- 3 days; 23, 7 ± 4, 3 kg body weight; 121 ± 4,8 cm body height, were involved in this study after written consent was obtained from their parents. The children's motor structure was established through the application of 28 tests that had been verified on the Slovene population and established as adequate for the study of motor abilities in the sample children. The factor analysis was applied to uncover the latent structure of motor space, and PB (Štalec Momirović criteria were used to establish the number of significant basic components. The analysis of the motor space structure revealed certain particularities for each age period. In the sample of 5 year old children, the use of PB criterion revealed four latent motor dimensions, in 6.5 year old children, the latent motor space structure was described with four (boys and five (girls factors. Despite the existence of gender differences in motor space structure and certain particularities in each age period mostly related to the factors which influence movement coordination, several very similar dimensions were discovered in both sexes.

  4. Comparação do desenvolvimento motor de lactentes de mães adolescentes e adultas Motor development comparison between infants of adolescent and adult mothers

    Directory of Open Access Journals (Sweden)

    Naiane Sartori

    2010-12-01

    Full Text Available Este estudo objetivou caracterizar o desempenho motor de bebês de 0 a 16 meses, comparando o de bebês nascidos de mães adolescentes ao de bebês de mães adultas. Participaram 80 bebês, sendo 40 de mães adolescentes e 40 de mães adultas. Os instrumentos avaliativos foram a escala motora infantil de Alberta AIMS (Alberta infant motor scale e questionário para identificar as características biológicas. Os dados foram analisados estatisticamente. Os resultados da AIMS mostram pior desempenho motor dos bebês de mães adolescentes (p=0,002; p=0,001, além de suas inadequadas aquisições motoras nas posturas prono e em pé. Não foi encontrada associação significativa entre a maioria dos fatores biológicos analisados e o desenvolvimento motor dos bebês. Os resultados sugerem que a idade materna pode ser considerada fator de risco para atraso motor em crianças, porém ressalta-se a interação de diferentes fatores, aqui não controlados, influenciando as aquisições motoras de crianças, tais como as demandas da tarefa e as condições do ambiente.The purpose of the study was to compare motor development of infants aged 0 to 16 months born of teenage mothers to those of adult mothers. Eighty babies were assessed, 40 of which the children of teenage mothers, and 40 of adult mothers. Instruments used were the Alberta infant motor scale (AIMS and a questionnaire to collect biological information. Data were statistically analysed. Results show teenage mothers' infants to have delayed motor development as compared to adult mothers' ones (p=0.002; p=0.001, as well as their poor motor acquisitions in prone and standing positions. No association was found between infants' motor development and most of the biological factors analysed. Results hence suggest that early maternal age may be considered a risk factor to motor delay in infants, but attention should be paid to other factors such as task requirements and environmental conditions (here

  5. Do active video games benefit the motor skill development of non-typically developing children and adolescents: A systematic review.

    Science.gov (United States)

    Page, Zoey E; Barrington, Stephanie; Edwards, Jacqueline; Barnett, Lisa M

    2017-12-01

    The use of interactive video gaming, known as 'exergames' or 'active video games (AVG)' may provide an opportunity for motor skill development. Youth with non-typical patterns of development may have deficits in gross motor skill capacities and are therefore an intervention target. The aim was to determine the effectiveness of AVG use on motor skill development in non-typically developing children and adolescents. Review article. The PRISMA protocol was used to conduct a systematic review of EBSCOhost, Embase, Gale Cengage, Informit, Ovid, ProQuest, PubMed, Scopus and Web of Science databases. A total of 19 articles met inclusion criteria (non-typically developing participants such as those with a learning or developmental delay aged 3-18, use of an AVG console, assessed one or more gross motor skills). Studies were excluded if gross motor skill outcomes encompassed fine motor skills or reflected mobility related to daily living. Interventions included children and adolescents with eight different conditions. The Nintendo Wii was the most utilised gaming platform (14/19 studies). Studies examined a combination of skills, with most examining balance (15/19), five studies examining ball skills, and other gross motor skills such as coordination (3 studies), running (3 studies) and jumping (3 studies). There was strong evidence that AVG's improved balance. AVG's also appeared to benefit participants with Cerebral Palsy. AVG's could be a valuable tool to improve gross motor skills of non-typically developing children. There is scope for further exploration, particularly of ball, coordination and locomotor skills and varying platforms to draw more conclusive evaluations. Copyright © 2017 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.

  6. Normative data on mental and motor development in Nigerian children

    African Journals Online (AJOL)

    Normative data on mental and motor development in Nigerian children. ... Inventory (DSI) and Bayley Scales of Infant Development (BSID): a screening and ... and the scores made blind to the researchers until after the subject\\'s assessment ...

  7. Electric vehicle traction motors - The development of an advanced motor concept

    Science.gov (United States)

    Campbell, P.

    1980-01-01

    An axial-field permanent magnet traction motor is described, similar to several advanced motors that are being developed in the United States. This type of machine has several advantages over conventional dc motors, particularly in the electric vehicle application. The rapidly changing cost of magnetic materials, particularly cobalt, makes it important to study the utilization of permanent magnet materials in such machines. The impact of different magnets on machine design is evaluated, and the advantages of using iron powder composites in the armature are assessed.

  8. Development of Motorized Oil Palm Fruit Rotary Digester | Asoiro ...

    African Journals Online (AJOL)

    A motorized oil palm fruit rotary digester comprising of a feed hopper, hammers, axle, screening plate, v-belt, 2hp electric motor, digesting chamber and frame was designed and developed using standard and locally sourced materials. The performance test analysis showed that its throughput capacity is 117.93kg/hr with a ...

  9. Studying Environmental Influence on Motor Development in Children

    Science.gov (United States)

    Gabbard, Carl; Krebs, Ruy

    2012-01-01

    There is a good argument that in order to truly understand the influences that shape child motor development, one must consider environmental influences that reflect the multilevel ecological contexts that interact with the changing biological characteristics of the child. Although there are theories typically associated with motor development…

  10. Gender Expression and Homophobia: A Motor Development and Learning Perspective

    Science.gov (United States)

    Garcia, Clersida

    2011-01-01

    Homosexuality and homophobia are rarely discussed in schools, yet they are relevant in motor-development and motor-learning settings because people hold gender-stereotyped beliefs about movement and about lesbian, gay, bisexual, or transgendered individuals. This article addresses homophobia and related stereotypes in physical education settings…

  11. The link between motor and cognitive development in children born preterm and/or with low birth weight : A review of current evidence

    NARCIS (Netherlands)

    Oudgenoeg-Paz, Ora; Mulder, Hanna; Jongmans, Marian J.; van der Ham, Ineke J.M.; Van der Stigchel, Stefan

    2017-01-01

    The current review focuses on evidence for a link between early motor development and later cognitive skills in children born preterm or with Low Birth Weight (LBW). Studies with term born children consistently show such a link. Motor and cognitive impairments or delays are often seen in children

  12. Delays in clinical development of neurological drugs in Japan.

    Science.gov (United States)

    Ikeda, Masayuki

    2017-06-28

    The delays in the approval and development of neurological drugs between Japan and other countries have been a major issue for patients with neurological diseases. The objective of this study was to analyze factors contributing to the delay in the launching of neurological drugs in Japan. We analyzed data from Japan and the US for the approval of 42 neurological drugs, all of which were approved earlier in the US than in Japan, and examined the potential factors that may cause the delay of their launch. Introductions of the 42 drugs in Japan occurred at a median of 87 months after introductions in the US. The mean review time of new drug applications for the 20 drugs introduced in Japan in January 2011 or later (15 months) was significantly shorter than that for the other 22 drugs introduced in Japan in December 2010 or earlier (24 months). The lag in the Japan's review time behind the US could not explain the approval delays. In the 31 of the 42 drugs, the application data package included overseas data. The mean review time of these 31 drugs (17 months) was significantly shorter than that of the other 11 drugs without overseas data (26 months). The mean approval lag behind the US of the 31 drugs (78 months) was also significantly shorter than that of the other 11 drugs (134 months). These results show that several important reforms in the Japanese drug development and approval system (e.g., inclusion of global clinical trial data) have reduced the delays in the clinical development of neurological drugs.

  13. Divergent Development of Gross Motor Skills in Children Who Are Blind or Sighted

    Science.gov (United States)

    Brambring, Michael

    2006-01-01

    This empirical study compared the average ages at which four congenitally blind children acquired 29 gross motor skills with age norms for sighted children. The results indicated distinct developmental delays in the acquisition of motor skills and a high degree of variability in developmental delays within and across the six subdomains that were…

  14. Recent developments in esophageal motor disorders

    NARCIS (Netherlands)

    Beaumont, Hanneke; Boeckxstaens, Guy

    2007-01-01

    PURPOSE OF REVIEW: Every year more insight into the pathogenesis and treatment of esophageal motor disorders is obtained. This review highlights some interesting literature published in this area during the last year. RECENT FINDINGS: Longitudinal and circular muscle contractions act in a well

  15. Experimental development of an ultrasonic linear motor

    CSIR Research Space (South Africa)

    M'Boungui, G

    2010-01-01

    Full Text Available the stator structure. In contrast to traditional travelling wave ultrasonic motors, which require two modes to be driven 90° out of phase, only one amplifier is required to drive the proposed device. A prototype device was characterised experimentally...

  16. Drawings of very preterm-born children at 5 years of age: a first impression of cognitive and motor development?

    Science.gov (United States)

    Schepers, Sasja; Deković, Maja; Feltzer, Max; de Kleine, Martin; van Baar, Anneloes

    2012-01-01

    The aim of this study was to examine differences in drawing skills between very preterm and term children, and to determine whether very preterm children's cognitive and motor development is reflected in the draw-a-person test (DAP) at age 5. Seventy-two very preterm children (birth weight children at 5 years of age were compared on the DAP. Cognitive and motor skills of the very preterm children had been assessed four times, at 1/2, 1, 2, and 5 years of age. Very preterm children showed a developmental delay in drawing ability. Structural equation modeling revealed a positive relation between both cognitive as well as motor development and the DAP. The DAP could be a crude parameter for evaluating cognitive and motor deficits of very preterm children. A worrisome result should be followed by more standardized tests measuring cognitive and motor skills.

  17. Research Review: Do motor deficits during development represent an endophenotype for schizophrenia?

    DEFF Research Database (Denmark)

    Burton, Birgitte Klee; Hjorthøj, Carsten; Jepsen, Jens Richardt M.

    2016-01-01

    to youth from families with other psychiatric disorders, the FDR group was distinguished by poorer gross and fine motor skills (k = 2, n = 275, g = 0.847, CI = [0.393, 1.300], p ...-analysis was conducted comparing individuals ≤21 years old with affected first-degree relatives (FDR) with (1) individuals from unaffected families (controls), or (2) individuals with FDR having other psychiatric disorders. Studies were classified by motor outcome and separate meta-analyses were performed across six...... correlated domains, with available N varying by domain. RESULTS: Inclusion criteria were met by k = 23 independent studies with a total N = 18,582, and N across domains varying from 167 to 8619. The youth from affected families had delays in gross and fine motor development in infancy (k = 3, n = 167, Hedges...

  18. Speech Motor Programming in Apraxia of Speech: Evidence from a Delayed Picture-Word Interference Task

    Science.gov (United States)

    Mailend, Marja-Liisa; Maas, Edwin

    2013-01-01

    Purpose: Apraxia of speech (AOS) is considered a speech motor programming impairment, but the specific nature of the impairment remains a matter of debate. This study investigated 2 hypotheses about the underlying impairment in AOS framed within the Directions Into Velocities of Articulators (DIVA; Guenther, Ghosh, & Tourville, 2006) model: The…

  19. DEVELOPING STUDENT SOCIALIZATION THROUGH MOTOR ACTIVITIES

    Directory of Open Access Journals (Sweden)

    Ioan Sabin SOPA

    2016-10-01

    Full Text Available : Starting from the assumption that motor activities are the perfect environment for socialization, communication and social integration of young people, this study aims to analyze the effectiveness of these activities in improving intergroup relations at the university level. In this research, the samples were composed of two groups, the experimental group (n = 25 with students from the Physical Education specialization and control group B (n = 25, composed of students from the Faculty of Sciences. The sociological survey applied on the two samples aimed to analyze the level of socialization, communication and social integration of students. The findings showed that the experimental group is more united, having a higher level of socialization and communication, compared to the control group B, proving once again the socializing effects of motor activities.

  20. Development of an electrically driven molecular motor.

    Science.gov (United States)

    Murphy, Colin J; Sykes, E Charles H

    2014-10-01

    For molecules to be used as components in molecular machinery, methods are required that couple individual molecules to external energy sources in order to selectively excite motion in a given direction. While significant progress has been made in the construction of synthetic molecular motors powered by light and by chemical reactions, there are few experimental examples of electrically driven molecular motors. To this end, we pioneered the use of a new, stable and tunable molecular rotor system based on surface-bound thioethers to comprehensively study many aspects of molecular rotation. As biological molecular motors often operate at interfaces, our synthetic system is especially amenable to microscopic interrogation as compared to solution-based systems. Using scanning tunneling microscopy (STM) and density functional theory, we studied the rotation of surface-bound thioethers, which can be induced either thermally or by electrons from the STM tip in a two-terminal setup. Moreover, the temperature and electron flux can be adjusted to allow each rotational event to be monitored at the molecular scale in real time. This work culminated in the first experimental demonstration of a single-molecule electric motor, where the electrically driven rotation of a butyl methyl sulfide molecule adsorbed on a copper surface could be directionally biased. The direction and rate of the rotation are related to the chirality of both the molecule and the STM tip (which serves as the electrode), illustrating the importance of the symmetry of the metal contacts in atomic-scale electrical devices. Copyright © 2014 The Chemical Society of Japan and Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  1. Motor Skill Interventions to Improve Fundamental Movement Skills of Preschoolers with Developmental Delay

    Science.gov (United States)

    Kirk, Megan A.; Rhodes, Ryan E.

    2011-01-01

    Preschoolers with developmental delay (DD) are at risk for poor fundamental movement skills (FMS), but a paucity of early FMS interventions exist. The purpose of this review was to critically appraise the existing interventions to establish direction for future trials targeting preschoolers with DD. A total of 11 studies met the inclusion…

  2. [Diagnostic evaluation of the developmental level in children identified at risk of delay through the Child Development Evaluation Test].

    Science.gov (United States)

    Rizzoli-Córdoba, Antonio; Campos-Maldonado, Martha Carmen; Vélez-Andrade, Víctor Hugo; Delgado-Ginebra, Ismael; Baqueiro-Hernández, César Iván; Villasís-Keever, Miguel Ángel; Reyes-Morales, Hortensia; Ojeda-Lara, Lucía; Davis-Martínez, Erika Berenice; O'Shea-Cuevas, Gabriel; Aceves-Villagrán, Daniel; Carrasco-Mendoza, Joaquín; Villagrán-Muñoz, Víctor Manuel; Halley-Castillo, Elizabeth; Sidonio-Aguayo, Beatriz; Palma-Tavera, Josuha Alexander; Muñoz-Hernández, Onofre

    The Child Development Evaluation (or CDE Test) was developed in Mexico as a screening tool for child developmental problems. It yields three possible results: normal, slow development or risk of delay. The modified version was elaborated using the information obtained during the validation study but its properties according to the base population are not known. The objective of this work was to establish diagnostic confirmation of developmental delay in children 16- to 59-months of age previously identified as having risk of delay through the CDE Test in primary care facilities. A population-based cross-sectional study was conducted in one Mexican state. CDE test was administered to 11,455 children 16- to 59-months of age from December/2013 to March/2014. The eligible population represented the 6.2% of the children (n=714) who were identified at risk of delay through the CDE Test. For inclusion in the study, a block randomization stratified by sex and age group was performed. Each participant included in the study had a diagnostic evaluation using the Battelle Development Inventory, 2 nd edition. From the 355 participants included with risk of delay, 65.9% were male and 80.2% were from rural areas; 6.5% were false positives (Total Development Quotient ˃90) and 6.8% did not have any domain with delay (Domain Developmental Quotient <80). The proportion of delay for each domain was as follows: communication 82.5%; cognitive 80.8%; social-personal 33.8%; motor 55.5%; and adaptive 41.7%. There were significant differences in the percentages of delay both by age and by domain/subdomain evaluated. In 93.2% of the participants, developmental delay was corroborated in at least one domain evaluated. Copyright © 2015 Hospital Infantil de México Federico Gómez. Publicado por Masson Doyma México S.A. All rights reserved.

  3. Gross motor skill development of kindergarten children in Japan.

    Science.gov (United States)

    Aye, Thanda; Kuramoto-Ahuja, Tsugumi; Sato, Tamae; Sadakiyo, Kaori; Watanabe, Miyoko; Maruyama, Hitoshi

    2018-05-01

    [Purpose] The purposes of this study were to assess and explore the gender-based differences in gross motor skill development of 5-year-old Japanese children. [Subjects and Methods] This cross-sectional study recruited 60 healthy 5-year-old (third-year kindergarten, i.e., nencho ) children (34 boys, 26 girls) from one local private kindergarten school in Otawara city, Tochigi Prefecture, Japan. Gross motor skills, including six locomotor and six object control skills, were assessed using the test of gross motor development, second edition (TGMD-2). All subjects performed two trials of each gross motor skill, and the performances were video-recorded and scored. Assessment procedures were performed according to the standardized guidelines of the TGMD-2. [Results] The majority of subjects had an average level of overall gross motor skills. Girls had significantly better locomotor skills. Boys had significantly better object control skills. [Conclusion] The gross motor skill development of 5-year-old Japanese children involves gender-based differences in locomotor and object control skills. This study provided valuable information that can be used to establish normative references for the gross motor skills of 5-year-old Japanese children.

  4. Symmetry in Infancy: Analysis of Motor Development in Autism Spectrum Disorders

    Directory of Open Access Journals (Sweden)

    Gianluca Esposito

    2009-12-01

    Full Text Available Motor asymmetry, defined as the lack of symmetry in movements or postures, is often observed briefly in many typically developing children. However, if such asymmetry persists, it may be a sign of neurological disease. Recent studies have suggested that motor asymmetries may be an early symptom of Autism Spectrum Disorders (ASD. ASD involve a range of social, cognitive, and behavioral problems, at different degrees of functioning, which are thought to be the final common pathway of multiple etiological mechanisms. Furthermore, early identification of ASD has been recognized as a critical aspect for treatment. Our study aims to analyze symmetry in the motor milestones of infants with ASD compared with typically developing infants (TD or infants with other developmental delay (DD during the first year of life. Our results highlight that there are different patterns of motor symmetry in the groups. In particular, infants with ASD scored significantly poorer (higher levels of asymmetry then the TD and DD infants. We also identified two subgroups of infants with ASD, one with a typical level and the other with a lower level of motor functioning. Implications of the study for diagnosis and treatment are described.

  5. Recreating the scene: an effective way to provide delayed punishment for inappropriate motor behavior.

    OpenAIRE

    Van Houten, R; Rolider, A

    1988-01-01

    A mediated punishment procedure that involved recreating a behavioral sequence by guiding the subject through the behavior in the situation in which it occurred was used to suppress several severe problem behaviors in two developmentally delayed children. The mediational procedure was first used with a 4-year-old autistic boy for biting and then for foot stomping. Next the procedure was used for stealing and hoarding behavior with a multiply handicapped 17-year-old girl. Results indicated tha...

  6. The Development of Fine Motor Skills and its Relation to Cognitive Development in Young Children

    OpenAIRE

    Geng, Da; Zhang, Xingli; Shi, Jiannong

    2015-01-01

    Fine motor skills refer to any movement where an individual uses the small muscles or muscle areas of the hands and fingers; these movements serve to development of muscle while also improving the cognitive recognition of the object. Automatic fine motor skills can save limited attention resources for advanced cognition tasks as required by an individual; in the development of fine motor skills and cognition, the two abilities interact, some motor skills are the prerequisite for some cognitio...

  7. [A 34-year-old woman with delayed motor milestones, high arched palate, and proximal muscle weakness].

    Science.gov (United States)

    Yamamoto, T; Kitada, T; Hirasawa, E; Mori, H; Mizuno, Y

    1996-07-01

    We report a right-handed 34-year-old woman with diffuse muscle atrophy. The patient was a full-term infant of uneventful delivery, however, motor milestones were delayed in that neck control was obtained at 10 months of the age and she started to walk unassisted at 2 years of the age. Mental development was normal. She was unable to run with her mates at her kindergarten and she required a handrail when she walk up the stairs. She could not close her mouth completely at the primary school. She was unable to use a straw as a middle school pupil. Recently, she noted difficulty in raising her head from the supine position, and has become unable to walk a long distance. She was admitted to our hospital in September 17, 1994 when she was 34-year-old. On admission, general physical examination revealed that she looked slender weighing 38 kg with 149.5 cm height. She showed a high arched palate, slight scoliosis, and pes equinus. Otherwise general physical examination was unremarkable. Upon neurologic examination, she was alert and well oriented. Cranial nerves were unremarkable except for bilateral facial atrophy and moderate weakness. Her voice was of nasal quality, and swallowing was slightly difficult. No atrophy was noted in the sternocleidomastoid muscle. She showed waddling gait and positive Gowers' sign. Diffuse muscle atrophy was noted and mild to moderate weakness was presented more in the proximal part in both upper and lower extremities, however, deltoid muscles retained normal power. No ataxia was noted. All the deep tendon reflexes were lost. Sensation was intact. Routine laboratory examination was unremarkable. Serum CK was 56 IU/l. Electromyography revealed myogenic changes in the deltoid, biceps, and quadriceps muscles. A diagnostic biopsy was performed in the left biceps brachii muscle. The patient was discussed in the neurologic CPC, and the chief discussant arrived at the conclusion that the patient had nemaline myopathy. Opinions were divided among

  8. Fever during pregnancy and motor development in children

    DEFF Research Database (Denmark)

    Holst, Charlotte; Jørgensen, Sanne Ellegaard; Wohlfahrt, Jan

    2015-01-01

    AIM: The aim of this study was to examine how fever during pregnancy is associated with motor development in the child. METHOD: This cohort study was based on data from females and their children, from the Danish National Birth Cohort, who took part in an 18-month and/or 7-year follow-up study....... Information regarding fever (number of episodes, temperature, duration, and pregnancy week) was obtained around gestation week 12 and at the end of pregnancy. Assessments of motor development in early childhood were based on the ages at which the motor milestones 'sitting unsupported' (n=44 256) and 'walking...... unassisted' (n=53 959) were attained. The Developmental Coordination Disorder Questionnaire 2007 (DCDQ'07) was used to identify children with indication of developmental coordination disorder (DCD) at age 7 years (n=29 401). Any associations between the exposure to fever during pregnancy and motor...

  9. Development of a Computerized Adaptive Test of Children's Gross Motor Skills.

    Science.gov (United States)

    Huang, Chien-Yu; Tung, Li-Chen; Chou, Yeh-Tai; Wu, Hing-Man; Chen, Kuan-Lin; Hsieh, Ching-Lin

    2018-03-01

    To (1) develop a computerized adaptive test for gross motor skills (GM-CAT) as a diagnostic test and an outcome measure, using the gross motor skills subscale of the Comprehensive Developmental Inventory for Infants and Toddlers (CDIIT-GM) as the candidate item bank; and (2) examine the psychometric properties and the efficiency of the GM-CAT. Retrospective study. A developmental center of a medical center. Children with and without developmental delay (N=1738). Not applicable. The CDIIT-GM contains 56 universal items on gross motor skills assessing children's antigravity control, locomotion, and body movement coordination. The item bank of the GM-CAT had 44 items that met the dichotomous Rasch model's assumptions. High Rasch person reliabilities were found for each estimated gross motor skill for the GM-CAT (Rasch person reliabilities =.940-.995, SE=.68-2.43). For children aged 6 to 71 months, the GM-CAT had good concurrent validity (r values =.97-.98), adequate to excellent diagnostic accuracy (area under receiver operating characteristics curve =.80-.98), and moderate to large responsiveness (effect size =.65-5.82). The averages of items administered for the GM-CAT were 7 to 11, depending on the age group. The results of this study support the use of the GM-CAT as a diagnostic and outcome measure to estimate children's gross motor skills in both research and clinical settings. Copyright © 2017 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.

  10. Development of a superconducting claw-pole motor

    International Nuclear Information System (INIS)

    Watanabe, E.; Kikukawa, K.; Satoh, Y.; Torii, S.

    2008-01-01

    We have developed and produced a superconducting claw-pole motor for a trial purpose as a method to make the best use of the characteristic of superconductivity without collector rings or rotating superconducting coils that need to be cryocooled, and made some examinations. The unique feature in this motor is to have the mechanism that supports the reaction magnetic force generated in the axial direction

  11. Motor development in individuals with congenital adrenal hyperplasia: strength, targeting, and fine motor skill.

    Science.gov (United States)

    Collaer, Marcia L; Brook, Charles G D; Conway, Gerard S; Hindmarsh, Peter C; Hines, Melissa

    2009-02-01

    This study investigated early androgen influence on the development of human motor and visuomotor characteristics. Participants, ages 12-45 years, were individuals with congenital adrenal hyperplasia (CAH), a disorder causing increased adrenal androgen production before birth (40 females, 29 males) and their unaffected relatives (29 females, 30 males). We investigated grip strength and visuomotor targeting tasks on which males generally outperform females, and fine motor pegboard tasks on which females generally outperform males. Physical characteristics (height and weight) were measured to explore whether body parameters could explain differences in motor skills. Females with CAH were stronger and showed better targeting than unaffected females and showed reduced fine visuomotor skill on one pegboard measure, with no difference on the other. Males with CAH were weaker than unaffected males in grip strength but did not differ on the targeting or pegboard measures. Correction for body size could not explain the findings for females, but suggests that the reduced strength of males with CAH may relate to their smaller stature. Further, the targeting advantage in females with CAH persisted following adjustment for their greater strength. Results in females support the hypothesis that androgen may masculinize, or promote, certain motor characteristics at which males excel, and contribute to defeminization of certain fine motor characteristics at which females excel. Thus, these data suggest that organizational effects of androgens on behavior during prenatal life may extend to motor characteristics and may contribute to general sex differences in motor-related behaviors; however, alternative explanations based on activational influences of androgen or altered experiential factors cannot be excluded without further study.

  12. Electric motor systems in developing countries: Opportunities for efficiency improvement

    Energy Technology Data Exchange (ETDEWEB)

    Meyers, S.; Monahan, P.; Lewis, P.; Greenberg, S. [Lawrence Berkeley Lab., CA (United States); Nadel, S. [American Council for an Energy-Efficient Economy, Washington, DC (United States)

    1993-08-01

    This report presents an overview of the current status and efficiency improvement potential of industrial motor systems in developing countries. Better management of electric motor systems is of particular relevance in developing countries, where improved efficiency can lead to increased productivity and slower growth in electricity demand. Motor systems currently consume some 65--80% of the industrial electricity in developing countries. Drawing on studies from Thailand, India, Brazil, China, Pakistan, and Costa Rica, we describe potential efficiency gains in various parts of the motor system, from the electricity delivery system through the motor to the point where useful work is performed. We report evidence of a significant electricity conservation potential. Most of the efficiency improvement methods we examine are very cost-effective from a societal viewpoint, but are generally not implemented due to various barriers that deter their adoption. Drawing on experiences in North America, we discuss a range of policies to overcome these barriers, including education, training, minimum efficiency standards, motor efficiency testing protocols, technical assistance programs, and financial incentives.

  13. Different phase delays of peripheral input to primate motor cortex and spinal cord promote cancellation at physiological tremor frequencies.

    Science.gov (United States)

    Koželj, Saša; Baker, Stuart N

    2014-05-01

    Neurons in the spinal cord and motor cortex (M1) are partially phase-locked to cycles of physiological tremor, but with opposite phases. Convergence of spinal and cortical activity onto motoneurons may thus produce phase cancellation and a reduction in tremor amplitude. The mechanisms underlying this phase difference are unknown. We investigated coherence between spinal and M1 activity with sensory input. In two anesthetized monkeys, we electrically stimulated the medial, ulnar, deep radial, and superficial radial nerves; stimuli were timed as independent Poisson processes (rate 10 Hz). Single units were recorded from M1 (147 cells) or cervical spinal cord (61 cells). Ninety M1 cells were antidromically identified as pyramidal tract neurons (PTNs); M1 neurons were additionally classified according to M1 subdivision (rostral/caudal, M1r/c). Spike-stimulus coherence analysis revealed significant coupling over a broad range of frequencies, with the strongest coherence at <50 Hz. Delays implied by the slope of the coherence phase-frequency relationship were greater than the response onset latency, reflecting the importance of late response components for the transmission of oscillatory inputs. The spike-stimulus coherence phase over the 6-13 Hz physiological tremor band differed significantly between M1 and spinal cells (phase differences relative to the cord of 2.72 ± 0.29 and 1.72 ± 0.37 radians for PTNs from M1c and M1r, respectively). We conclude that different phases of the response to peripheral input could partially underlie antiphase M1 and spinal cord activity during motor behavior. The coordinated action of spinal and cortical feedback will act to reduce tremulous oscillations, possibly improving the overall stability and precision of motor control. Copyright © 2014 the American Physiological Society.

  14. Five-Segment Solid Rocket Motor Development Status

    Science.gov (United States)

    Priskos, Alex S.

    2012-01-01

    In support of the National Aeronautics and Space Administration (NASA), Marshall Space Flight Center (MSFC) is developing a new, more powerful solid rocket motor for space launch applications. To minimize technical risks and development costs, NASA chose to use the Space Shuttle s solid rocket boosters as a starting point in the design and development. The new, five segment motor provides a greater total impulse with improved, more environmentally friendly materials. To meet the mass and trajectory requirements, the motor incorporates substantial design and system upgrades, including new propellant grain geometry with an additional segment, new internal insulation system, and a state-of-the art avionics system. Significant progress has been made in the design, development and testing of the propulsion, and avionics systems. To date, three development motors (one each in 2009, 2010, and 2011) have been successfully static tested by NASA and ATK s Launch Systems Group in Promontory, UT. These development motor tests have validated much of the engineering with substantial data collected, analyzed, and utilized to improve the design. This paper provides an overview of the development progress on the first stage propulsion system.

  15. Delayed neuropsychiatric sequelae after acute hydrogen sulfide poisoning: affection of motor function, memory, vision and hearing.

    Science.gov (United States)

    Tvedt, B; Edland, A; Skyberg, K; Forberg, O

    1991-10-01

    A shipyard worker was poisoned by hydrogen sulfide (H2S), and rescued after 15-20 min. He regained consciousness after 2 days. Three days later his condition deteriorated, and he was more or less comatose for a month. When he woke up, he was amnesic, nearly blind, had reduced hearing, and had a moderate spastic tetraparesis and ataxia. Two months after the accident, he had greatly improved. Audiograms showed hearing loss with maximum at 2000 Hz and significantly poorer speech discrimination. EEG showed generalized dysrhythmia. At follow-up 5 years later he had not been able to resume his work, and had slight motor, memory and visual symptoms. CT and MRI showed slight cerebral atrophy. EEG and evoked responses were normal.

  16. Motor development of preterm and term infants in the fundamental movement phase: a cross-sectional study

    Directory of Open Access Journals (Sweden)

    Joyce Karla Machado da Silva

    Full Text Available Abstract Introduction: Motor development is a continuous process of motor behavior changes throughout life, allowing for movement control. Premature birth can affect this process, with a greater risk of delays in acquiring these skills. Objective: Compare motor development during the fundamental movement phase of preterm infants submitted to early stimulation and full-term babies. Methods: An analytical cross-sectional study with convenience sampling, performed with twenty 3-year-old children of both sexes, distributed into two groups: the preterm group (n = 10, which received physical therapy in the first months of life, and the term group (n = 10. Motor development stages were assessed between January and April 2013, using the Motor Development Scale (Escala de Desenvolvimento Motor - EDM developed by Francisco Rosa Neto, with an average execution time of thirty minutes. Statistical analysis was performed using BioEstat 5.0 software, and the Shapiro-Wilk test was applied to verify data normality. A significance level of p ≤ 0.05 was adopted, analyzed using the Mann-Whitney test. Results: The term group exhibited significant differences in relation to the preterm group for the variables Fine and Gross Motor Skills, and Spatial and Temporal Awareness, with no differences in Balance and Body Scheme. Conclusion: Only the premature infants submitted to early intervention achieved normal levels of Balance and Body Scheme on the EDM Scale.

  17. Does Motor Development in Infancy Predict Spinal Pain in Later Childhood?

    DEFF Research Database (Denmark)

    Kamper, Steven J; Williams, Christopher M; Hestbaek, Lise

    2017-01-01

    first sat, and first walked without support. Predictors were measured by parent-report when the children were aged 6, and 18 months, along with a comprehensive list of covariates, including; child sex, birthweight and cognitive development, socioeconomic indicators, and parental health variables......Study Design Longitudinal cohort study. Background Spinal pain is responsible for a huge personal and societal burden but the aetiology remains unclear. Deficits in motor control have been implicated with spinal pain in adults, and delayed motor development is associated with a range of health...... problems and risks in children. Objectives To assess whether there is an independent relationship between the age at which infants first sit and walk without support, and spinal pain at age 11 years. Methods Data from the Danish National Birth Cohort were analysed. Predictors were age at which the child...

  18. Unilateral nasal obstruction affects motor representation development within the face primary motor cortex in growing rats.

    Science.gov (United States)

    Abe, Yasunori; Kato, Chiho; Uchima Koecklin, Karin Harumi; Okihara, Hidemasa; Ishida, Takayoshi; Fujita, Koichi; Yabushita, Tadachika; Kokai, Satoshi; Ono, Takashi

    2017-06-01

    Postnatal growth is influenced by genetic and environmental factors. Nasal obstruction during growth alters the electromyographic activity of orofacial muscles. The facial primary motor area represents muscles of the tongue and jaw, which are essential in regulating orofacial motor functions, including chewing and jaw opening. This study aimed to evaluate the effect of chronic unilateral nasal obstruction during growth on the motor representations within the face primary motor cortex (M1). Seventy-two 6-day-old male Wistar rats were randomly divided into control ( n = 36) and experimental ( n = 36) groups. Rats in the experimental group underwent unilateral nasal obstruction after cauterization of the external nostril at 8 days of age. Intracortical microstimulation (ICMS) mapping was performed when the rats were 5, 7, 9, and 11 wk old in control and experimental groups ( n = 9 per group per time point). Repeated-measures multivariate ANOVA was used for intergroup and intragroup statistical comparisons. In the control and experimental groups, the total number of positive ICMS sites for the genioglossus and anterior digastric muscles was significantly higher at 5, 7, and 9 wk, but there was no significant difference between 9 and 11 wk of age. Moreover, the total number of positive ICMS sites was significantly smaller in the experimental group than in the control at each age. It is possible that nasal obstruction induced the initial changes in orofacial motor behavior in response to the altered respiratory pattern, which eventually contributed to face-M1 neuroplasticity. NEW & NOTEWORTHY Unilateral nasal obstruction in rats during growth periods induced changes in arterial oxygen saturation (SpO 2 ) and altered development of the motor representation within the face primary cortex. Unilateral nasal obstruction occurring during growth periods may greatly affect not only respiratory function but also craniofacial function in rats. Nasal obstruction should be treated

  19. Motor skill delays in pre-school children with leukemia one year after treatment: Hematopoietic stem cell transplantation therapy as an important risk factor.

    Science.gov (United States)

    Taverna, Livia; Tremolada, Marta; Bonichini, Sabrina; Tosetto, Barbara; Basso, Giuseppe; Messina, Chiara; Pillon, Marta

    2017-01-01

    CNS-directed therapies for the treatment of leukemia can adversely affect the acquisition of new skills, such as reading/writing and math. Two years after the end of treatments, children show gross and fine motor skill delays that may persist even when patients are considered healed. The goal of the present study was to assess motor skills difficulties in pre-school children with leukemia one year after treatment. Particular attention has been paid to those patients who had undergone Hematopoietic Stem Cell Transplantation (HSCT) and to the relationship between motor delays and age bands. Participants were 60 children (median age of 5; inter quartile range: 3.07-5.76), including 31 females and 29 males, 91.7% of them were affected by acute lymphoblastic leukemia (ALL), and 8.3% by acute myeloid leukemia (AML). Five children had undergone HCST. Parents were interviewed by Vineland Adaptive Behavior Scales (VABS) on children's motor skills and filled in the Italian Temperament Questionnaire (QUIT). VABS's total scores were converted into equivalent mental age scores (EMA). A score difference of at least three months between current age and equivalent mental age was considered a developmental delay. Non-parametric analyses were run to understand if HSCT treatment and a specific age band influence children's motor skills. Significant delays were found in global motor skills (56.7%) as well as in fine and gross motor domains. Mann Whitney U tests showed that children with HSCT were reported to have lower gross motor mean ranks (U = 62; p = 0.004; Mean rank = 15.40) than peers without HSCT (Mean rank = 31.87) and lower mean rank values on motor temperament scale (U = 9; p = 0.003; HSCT Mean rank = 4.75 versus no HSCT Mean rank = 27.81). Kruskal Wallis' tests identified the high risk treatment showing that HSCT experience negatively impacted the motor skills and temperamental motor activity of pre-school children one year after the diagnosis of leukemia.

  20. Motor skill delays in pre-school children with leukemia one year after treatment: Hematopoietic stem cell transplantation therapy as an important risk factor.

    Directory of Open Access Journals (Sweden)

    Livia Taverna

    Full Text Available CNS-directed therapies for the treatment of leukemia can adversely affect the acquisition of new skills, such as reading/writing and math. Two years after the end of treatments, children show gross and fine motor skill delays that may persist even when patients are considered healed. The goal of the present study was to assess motor skills difficulties in pre-school children with leukemia one year after treatment. Particular attention has been paid to those patients who had undergone Hematopoietic Stem Cell Transplantation (HSCT and to the relationship between motor delays and age bands. Participants were 60 children (median age of 5; inter quartile range: 3.07-5.76, including 31 females and 29 males, 91.7% of them were affected by acute lymphoblastic leukemia (ALL, and 8.3% by acute myeloid leukemia (AML. Five children had undergone HCST. Parents were interviewed by Vineland Adaptive Behavior Scales (VABS on children's motor skills and filled in the Italian Temperament Questionnaire (QUIT. VABS's total scores were converted into equivalent mental age scores (EMA. A score difference of at least three months between current age and equivalent mental age was considered a developmental delay. Non-parametric analyses were run to understand if HSCT treatment and a specific age band influence children's motor skills. Significant delays were found in global motor skills (56.7% as well as in fine and gross motor domains. Mann Whitney U tests showed that children with HSCT were reported to have lower gross motor mean ranks (U = 62; p = 0.004; Mean rank = 15.40 than peers without HSCT (Mean rank = 31.87 and lower mean rank values on motor temperament scale (U = 9; p = 0.003; HSCT Mean rank = 4.75 versus no HSCT Mean rank = 27.81. Kruskal Wallis' tests identified the high risk treatment showing that HSCT experience negatively impacted the motor skills and temperamental motor activity of pre-school children one year after the diagnosis of leukemia.

  1. Motor skill delays in pre-school children with leukemia one year after treatment: Hematopoietic stem cell transplantation therapy as an important risk factor

    Science.gov (United States)

    Bonichini, Sabrina; Tosetto, Barbara; Basso, Giuseppe; Messina, Chiara; Pillon, Marta

    2017-01-01

    CNS-directed therapies for the treatment of leukemia can adversely affect the acquisition of new skills, such as reading/writing and math. Two years after the end of treatments, children show gross and fine motor skill delays that may persist even when patients are considered healed. The goal of the present study was to assess motor skills difficulties in pre-school children with leukemia one year after treatment. Particular attention has been paid to those patients who had undergone Hematopoietic Stem Cell Transplantation (HSCT) and to the relationship between motor delays and age bands. Participants were 60 children (median age of 5; inter quartile range: 3.07–5.76), including 31 females and 29 males, 91.7% of them were affected by acute lymphoblastic leukemia (ALL), and 8.3% by acute myeloid leukemia (AML). Five children had undergone HCST. Parents were interviewed by Vineland Adaptive Behavior Scales (VABS) on children’s motor skills and filled in the Italian Temperament Questionnaire (QUIT). VABS’s total scores were converted into equivalent mental age scores (EMA). A score difference of at least three months between current age and equivalent mental age was considered a developmental delay. Non-parametric analyses were run to understand if HSCT treatment and a specific age band influence children’s motor skills. Significant delays were found in global motor skills (56.7%) as well as in fine and gross motor domains. Mann Whitney U tests showed that children with HSCT were reported to have lower gross motor mean ranks (U = 62; p = 0.004; Mean rank = 15.40) than peers without HSCT (Mean rank = 31.87) and lower mean rank values on motor temperament scale (U = 9; p = 0.003; HSCT Mean rank = 4.75 versus no HSCT Mean rank = 27.81). Kruskal Wallis’ tests identified the high risk treatment showing that HSCT experience negatively impacted the motor skills and temperamental motor activity of pre-school children one year after the diagnosis of leukemia. PMID

  2. RISK FACTORS OF DELAYS OF CHILD PHYSICAL DEVELOPMENT

    Directory of Open Access Journals (Sweden)

    T.I. Kaganova

    2008-01-01

    Full Text Available Research targeted studying risk factors for delays physical development of children (n = 70 aged 7–11 years. Control group was comprised of 30 children of normal height of the same age. Physical development was evaluated by centile method using regional and international standards, studying data of life and disease anamnesis, family anamnesis, living conditions. Children had their thyroid glands studied ultrasonically. Blood levels of calcium, phosphor, magnesium, ferrum, zinc were identified by photometry method for some children in both groups. Correlation analysis makes it possible to state risk factors of children dwarfism: low educational status of parents, child height figures at the age of 1 and 3 years, calcium and phosphor blood levels, as well as thyroid hypo plasy.Key words: dwarfism, children, risk factors, calcium deficit.

  3. Children in Institutional Care: Delayed Development and Resilience

    Science.gov (United States)

    van IJzendoorn, Marinus H.; Palacios, Jesus; Sonuga-Barke, Edmund J. S.; Gunnar, Megan R.; Vorria, Panayiota; McCall, Robert B.; LeMare, Lucy; Bakermans-Kranenburg, Marian J.; Dobrova-Krol, Natasha A.; Juffer, Femmie

    2010-01-01

    Children exposed to institutional care often suffer from “structural neglect” which may include minimum physical resources, unfavorable and unstable staffing patterns, and social-emotionally inadequate caregiver-child interactions. This chapter is devoted to the analysis of the ill effects of early institutional experiences on resident children’s development. Delays in the important areas of physical, hormonal, cognitive, and emotional development are discussed. The evidence for and against the existence of a distinctive set of co-occurring developmental problems in institutionalized children is weighed and found to not yet convincingly demonstrate a “post-institutional syndrome”. Finally, shared and non-shared features of the institutional environment and specific genetic, temperamental, and physical characteristics of the individual child are examined that might make a crucial difference in whether early institutional rearing leaves irreversible scars. PMID:25125707

  4. Early motor development and cognitive abilities among Mexican preschoolers.

    Science.gov (United States)

    Osorio-Valencia, Erika; Torres-Sánchez, Luisa; López-Carrillo, Lizbeth; Rothenberg, Stephen J; Schnaas, Lourdes

    2017-07-18

    Psychomotricity plays a very important role in children's development, especially for learning involving reading-writing and mathematical calculations. Evaluate motor development in children 3 years old and its relationship with their cognitive abilities at the age of 5 years. Based on a cohort study, we analyzed the information about motor performance evaluated at 3 years old by Peabody Motor Scale and cognitive abilities at 5 years old. The association was estimated using linear regression models adjusted by mother's intelligence quotient, sex, Bayley mental development index at 18 months, and quality of the environment at home (HOME scale). 148 children whose motor performance was determined at age 3 and was evaluated later at age 5 to determine their cognitive abilities. Cognitive abilities (verbal, quantitative, and memory) measured by McCarthy Scales. Significant positive associations were observed between stationary balance at age 3 with verbal abilities (β = 0.67, p = .04) and memory (β = 0.81, p = .02) at 5 years. Grasping and visual-motor integration were significant and positively associated with quantitative abilities (β = 0.74, p = .005; β = 0.61, p = .01) and memory (β = 2.11, p = .001; β = 1.74, p = .004). The results suggest that early motor performance contributes to the establishment of cognitive abilities at 5 years. Evaluation and early motor stimulation before the child is faced with formal learning likely helps to create neuronal networks that facilitate the acquisition of academic knowledge.

  5. Motor development of kindergarten in 13 months interval

    Directory of Open Access Journals (Sweden)

    Lilian Teresa Bucken Gobbi

    2005-12-01

    Full Text Available Motor development is a changing process of individual functioning level where a better capacity to control movements is acquiring with time. Then, the purpose of this study was to analyze the changes in children motor behavior in 13 months interval. Thirty-five children ranging from 3 to 7 years of age participated and were distributed in 4 age groups. The motor performance of each participant were evaluated and reevaluated after 13 months by means of the Motor Development Scale, which is a test battery with specific tasks according to the age for each component: fine skill, global skill, balance, body schema/fastness, and spatial organization. Motor performance was compared inter and intra groups for each component. The results showed that the motor performance in the balance tasks improved after the 13 months for all age groups; for fine skill, global skill, and body schema children of 3, 4, and 5 years of age improved their performances between the evaluations; for spatial organization only children of 3 and 5 years of age improved their performances when reevaluated. These results suggest that the development in this age range occurs in a no homogeneous way, i.e., it presents different rhythms for the motor components. Environmental, individual and task factors can explain the developmental changes in a 13 months period. We conclude that the developmental process of each motor component is dynamic and it presents no linearity aspects. RESUMO O desenvolvimento motor é um processo de mudanças no nível de funcionamento de um indivíduo, onde uma maior capacidade de controlar movimentos é adquirida ao longo do tempo. Assim, o objetivo principal deste estudo foi analisar as mudanças no comportamento motor de crianças no intervalo de 13 meses. Participaram deste estudo 35 crianças entre 3 e 7 anos de idade distribuídas por faixa etária em 4 grupos. O desempenho motor de cada participante foi avaliado e re-avaliado após 13 meses por meio

  6. Perinatal Development of the Motor Systems Involved in Postural Control

    Directory of Open Access Journals (Sweden)

    Laurent Vinay

    2005-01-01

    Full Text Available Motor behaviors of some species, such as the rat and the human baby, are quite immature at birth. Here we review recent data on some of the mechanisms underlying the postnatal maturation of posture in the rat, in particular the development of pathways descending from the brain stem and projecting onto the lumbar enlargement of the spinal cord. A short-lasting depletion in serotonin affects both posture and the excitability of motoneurons. Here we try to extrapolate to human development and suggest that the abnormalities in motor control observed in childhood—e.g, deficits in motor coordination—might have their roots in the prenatal period, in particular serotonin depletion due to exposure to several environmental and toxicological factors during pregnancy.

  7. Older Siblings Influence Younger Siblings' Motor Development

    Science.gov (United States)

    Berger, Sarah E.; Nuzzo, Katie

    2008-01-01

    Evidence exists for two competing theories about the effects of having an older sibling on development. Previous research has found that having an older sibling has both advantages and disadvantages for younger siblings' development. This study examined whether and how older siblings influenced the onset of their own younger siblings' motor…

  8. The interrelationships between motor, cognitive, and language development in children with and without intellectual and developmental disabilities.

    Science.gov (United States)

    Houwen, Suzanne; Visser, Linda; van der Putten, Annette; Vlaskamp, Carla

    2016-01-01

    It is generally agreed that cognitive and language development are dependent on the emergence of motor skills. As the literature on this issue concerning children with developmental disabilities is scarce, we examined the interrelationships between motor, cognitive, and language development in children with intellectual and developmental disabilities (IDD) and compared them to those in children without IDD. In addition, we investigated whether these relationships differ between children with different levels of cognitive delay. Seventy-seven children with IDD (calendar age between 1;0 and 9;10 years; mean developmental age: 1;8 years) and 130 typically developing children (calendar age between 0;3 and 3;6 years; mean developmental age: 1;10 years) were tested with the Dutch Bayley Scales of Infant and Toddler Development, Third Edition, which assesses development across three domains using five subscales: fine motor development, gross motor development (motor), cognition (cognitive), receptive communication, and expressive communication (language). Results showed that correlations between the motor, cognitive, and language domains were strong, namely .61 to .94 in children with IDD and weak to strong, namely .24 to .56 in children without IDD. Furthermore, the correlations showed a tendency to increase with the severity of IDD. It can be concluded that both fine and gross motor development are more strongly associated with cognition, and consequently language, in children with IDD than in children without IDD. The findings of this study emphasize the importance of early interventions that boost both motor and cognitive development, and suggest that such interventions will also enhance language development. Copyright © 2016 Elsevier Ltd. All rights reserved.

  9. Automated delay estimation at signalized intersections : phase I concept and algorithm development.

    Science.gov (United States)

    2011-07-01

    Currently there are several methods to measure the performance of surface streets, but their capabilities in dynamically estimating vehicle delay are limited. The objective of this research is to develop a method to automate traffic delay estimation ...

  10. Perinatal asphyxia: CNS development and deficits with delayed onset

    Directory of Open Access Journals (Sweden)

    Mario eHerrera-Marschitz

    2014-03-01

    Full Text Available Perinatal asphyxia constitutes a prototype of obstetric complications occurring when pulmonary oxygenation is delayed or interrupted. The primary insult relates to the duration of the period lacking oxygenation, leading to death if not re-established. Re-oxygenation leads to a secondary insult, related to a cascade of biochemical events required for restoring proper function. Perinatal asphyxia interferes with neonatal development, resulting in long-term deficits associated to mental and neurological diseases with delayed clinical onset, by mechanisms not yet clarified.In the experimental scenario, the effects observed long after perinatal asphyxia have been explained by over expression of sentinel proteins, such as poly(ADP-ribose polymerase-1 (PARP-1, competing for NAD+ during re-oxygenation, leading to the idea that sentinel protein inhibition constitutes a suitable therapeutic strategy. Asphyxia induces transcriptional activation of pro-inflammatory factors, in tandem with PARP-1 overactivation, and pharmacologically induced PARP-1 inhibition also down-regulates the expression of proinflammatory cytokines. Nicotinamide has been proposed as a suitable PARP-1 inhibitor. Its effect has been studied in an experimental model of global hypoxia in rats. In that model, the insult is induced by immersing rat foetuses into a water bath for various periods of time. Following asphyxia, the pups are delivered, treated, and nursed by surrogate dams, pending further experiments. Nicotinamide rapidly distributes into the brain following systemic administration, reaching steady state concentrations sufficient to inhibit PARP-1 activity for several hours, preventing several of the long-term consequences of perinatal asphyxia, supporting the idea that it constitutes a lead for exploring compounds with similar or better pharmacological profiles.

  11. Motor development following in utero exposure to organochlorines

    DEFF Research Database (Denmark)

    Høyer, Birgit Bjerre; Ramlau-Hansen, Cecilia Høst; Pedersen, Henning Sloth

    2015-01-01

    of child age at the first time of crawling, standing-up and walking. RESULTS: We saw no associations between tertiles of CB-153 and p,p'-DDE or log-transformed exposures and retrospective reports of the developmental milestones crawling, standing-up and walking in infancy or the motor skills measured...... as developmental coordination disorder at young school age. CONCLUSIONS: In utero exposure to CB-153 and p,p'-DDE was not associated with parentally retrospectively assessed developmental milestones in infancy or parentally assessed motor skills at young school age. The use of a more sensitive outcome measure may......BACKGROUND: Prior studies on the association between prenatal exposure to polychlorinated biphenyls (PCBs) and dichlorodiphenyldichloroethylene (DDE) and child motor development have found contradicting results. Using data collected in the INUENDO cohort in Kharkiv (Ukraine), Warsaw (Poland...

  12. The Dynamic Association between Motor Skill Development and Physical Activity

    Science.gov (United States)

    Stodden, David F.; Goodway, Jacqueline D.

    2007-01-01

    Although significant attention has been given to promoting physical activity among children, little attention has been given to the developmental process of how children learn to move or to the changing role that motor skill development plays in children's physical activity levels as they grow. In order to successfully address the obesity…

  13. Motor Development of Deaf Children with and without Cochlear Implants

    Science.gov (United States)

    Gheysen, Freja; Loots, Gerrit; Van Waelvelde, Hilde

    2008-01-01

    The purpose of this study was to investigate the impact of a cochlear implant (CI) on the motor development of deaf children. The study involved 36 mainstreamed deaf children (15 boys, 21 girls; 4- to 12-years old) without any developmental problems. Of these children, 20 had been implanted. Forty-three hearing children constituted a comparison…

  14. METHODIC OF DEVELOPMENT OF MOTOR GIFTEDNESS OF PRESCHOOL CHILDREN

    Directory of Open Access Journals (Sweden)

    Светлана Юрьевна Федорова

    2013-05-01

    Full Text Available Education and training of gifted children today appropriate to consider as an important strategic task of modern society. In this context, the purpose of research is the development motor giftedness, which is particularly relevant at the stage of pre-school education, which is caused by age-preschoolers. Preschoolers' motor giftedness is considered by the author as developing integrated quality, including psychomotor skills, inclinations, increased motivation for motor activity. In the process of study the following methods are used:  the study and analysis of the scientific and methodological literature on studies, questioning, interview, testing of physical fitness, statistical data processing.The result of research work is methodic of development of motor giftedness on physical education in preschool. The author's methodic consists of four steps:  diagnostic, prognostic, practice and activity, social and pedagogical. Each step determines the inclusion of preschool children in sports and developing environment that meets his or her abilities and needs through the creation of certain social and educational conditions.The area of using results of the author's methodic is preschool and the system of improvement professional skill of teachers. DOI: http://dx.doi.org/10.12731/2218-7405-2013-4-31

  15. Psychologically Inspired Sensory-Motor Development in Early Robot Learning

    Directory of Open Access Journals (Sweden)

    M.H. Lee

    2008-11-01

    Full Text Available We present an implementation of a model of very early sensory-motor development, guided by results from developmental psychology. Behavioural acquisition and growth is demonstrated through constraint-lifting mechanisms initiated by global state variables. The results show how staged competence can be shaped by qualitative behaviour changes produced by anatomical, computational and maturational constraints.

  16. METHODIC OF DEVELOPMENT OF MOTOR GIFTEDNESS OF PRESCHOOL CHILDREN

    Directory of Open Access Journals (Sweden)

    Fedorova Svetlana Yurievna

    2013-04-01

    Full Text Available Education and training of gifted children today appropriate to consider as an important strategic task of modern society. In this context, the purpose of research is the development motor giftedness, which is particularly relevant at the stage of pre-school education, which is caused by age-preschoolers. Preschoolers' motor giftedness is considered by the author as developing integrated quality, including psychomotor skills, inclinations, increased motivation for motor activity. In the process of study the following methods are used: the study and analysis of the scientific and methodological literature on studies, questioning, interview, testing of physical fitness, statistical data processing. The result of research work is methodic of development of motor giftedness on physical education in preschool. The author's methodic consists of four steps: diagnostic, prognostic, practice and activity, social and pedagogical. Each step determines the inclusion of preschool children in sports and developing environment that meets his or her abilities and needs through the creation of certain social and educational conditions. The area of using results of the author's methodic is preschool and the system of improvement professional skill of teachers.

  17. Early Speech Motor Development: Cognitive and Linguistic Considerations

    Science.gov (United States)

    Nip, Ignatius S. B.; Green, Jordan R.; Marx, David B.

    2009-01-01

    This longitudinal investigation examines developmental changes in orofacial movements occurring during the early stages of communication development. The goals were to identify developmental trends in early speech motor performance and to determine how these trends differ across orofacial behaviors thought to vary in cognitive and linguistic…

  18. Individual Differences in Language Development: Relationship with Motor Skill at 21 Months

    Science.gov (United States)

    Alcock, Katherine J.; Krawczyk, Kirsty

    2010-01-01

    Language development has long been associated with motor development, particularly manual gesture. We examined a variety of motor abilities--manual gesture including symbolic, meaningless and sequential memory, oral motor control, gross and fine motor control--in 129 children aged 21 months. Language abilities were assessed and cognitive and…

  19. Delayed growth, motor function and learning in preterm pigs during early postnatal life

    DEFF Research Database (Denmark)

    Andersen, Anders D.; Sangild, Per T.; Munch, Sara L.

    2016-01-01

    Preterm birth interrupts normal fetal growth with consequences for postnatal growth and organ development. In preterm infants, many physiological deficits adapt and disappear with advancing postnatal age, but some may persist into childhood. We hypothesized that preterm birth would induce impaired......, and learning, relative to term pigs (all P

  20. Motor Development Skills of 1- to 4-Year-Old Iranian Children with Early Treated Phenylketonuria

    Directory of Open Access Journals (Sweden)

    Firouzeh Sajedi

    2014-03-01

    Full Text Available Objective: To gauge the gross and fine motor development of early treated phenylketonuria (ETPKU in children in the age range of 1–4 years. Materials & Methods: A cross-sectional analytic study was conducted in PKU clinics (reference clinics for PKU follow-up, Tehran, Iran. Seventy children with ETPKU were selected as the case group for the study. ETPKU children were those with early and continuous treatment with a phenylalaninerestricted diet (the mean of blood phenylalanine level during the recent 6 months was 2–6 mg/dL or 120–360 mmol/L. Also, 100 healthy and normal children matched with the ETPKU group for age were randomly selected from 4 kindergartens in four parts of Tehran as a control group. The measurements consisted of a demographic questionnaire, Peabody Developmental Motor Scale-2 (PDMS-2, and pediatrician assessment. Motor quotients were determined by PDMS-2 and then compared in both groups by two independent samples t-test. Results: The mean ages in case and control group were 28.5 (±11.6 and 29.7 (±11.3 months, respectively. Comparison of the mean fine, gross, and total developmental motor quotients (DMQs showed statistically significant differences between the two groups (P<0.05. The fine and total DMQs of ETPKU children were also correlated with age. In addition, there was a negative correlation between the phenylalanine level and fine (P<0.001 and total (P=0.001 DMQs. Conclusion: It seems that ETPKU Iranian children, regardless of following a phenylalanine-restricted diet or not, have lower motor development. It is recommended to plan programs for early detection and intervention of developmental delays in these children.

  1. Motor development skills of 1- to 4-year-old Iranian children with early treated phenylketonuria.

    Science.gov (United States)

    Nazi, Sepideh; Rohani, Farzaneh; Sajedi, Firoozeh; Biglarian, Akbar; Setoodeh, Arya

    2014-01-01

    Objective : To gauge the gross and fine motor development of early treated phenylketonuria (ETPKU) in children in the age range of 1-4 years. Methods : A cross-sectional analytic study was conducted in PKU clinics (reference clinics for PKU follow-up), Tehran, Iran. Seventy children with ETPKU were selected as the case group for the study. ETPKU children were those with early and continuous treatment with a phenylalanine-restricted diet (the mean of blood phenylalanine level during the recent 6 months was 2-6 mg/dL or 120-360 μmol/L). Also, 100 healthy and normal children matched with the ETPKU group for age were randomly selected from 4 kindergartens in four parts of Tehran as a control group. The measurements consisted of a demographic questionnaire, Peabody Developmental Motor Scale-2 (PDMS-2), and pediatrician assessment. Motor quotients were determined by PDMS-2 and then compared in both groups by two independent samples t-test. Results : The mean ages in case and control group were 28.5 (± 11.6) and 29.7 (± 11.3) months, respectively. Comparison of the mean fine, gross, and total developmental motor quotients (DMQs) showed statistically significant differences between the two groups (p fine and total DMQs of ETPKU children were also correlated with age. In addition, there was a negative correlation between the phenylalanine level and fine (p motor development. It is recommended to plan programs for early detection and intervention of developmental delays in these children.

  2. Development and Construct Validation of an Inventory for Assessing the Home Environment for Motor Development

    Science.gov (United States)

    Rodrigues, Luis Paulo; Saraiva, Linda; Gabbard, Carl

    2005-01-01

    A contemporary view of early childhood motor development considers environmental influences as critical factors in optimal growth and behavior, with the home being the primary agent. However, there has been minimal research examining the relationship between motor development and the home. The present study addresses this gap with the goal of…

  3. Transgenerational effects of environmental enrichment on repetitive motor behavior development.

    Science.gov (United States)

    Bechard, Allison R; Lewis, Mark H

    2016-07-01

    The favorable consequences of environmental enrichment (EE) on brain and behavior development are well documented. Much less is known, however, about transgenerational benefits of EE on non-enriched offspring. We explored whether transgenerational effects of EE might extend to the development of repetitive motor behaviors in deer mice. Repetitive motor behaviors are invariant patterns of movement that, across species, can be reduced by EE. We found that EE not only attenuated the development of repetitive behavior in dams, but also in their non-enriched offspring. Moreover, maternal behavior did not seem to mediate the transgenerational effect we found, although repetitive behavior was affected by reproductive experience. These data support a beneficial transgenerational effect of EE on repetitive behavior development and suggest a novel benefit of reproductive experience. Copyright © 2016 Elsevier B.V. All rights reserved.

  4. Risk Factors and Relationship Between Intestinal Parasites and the Growth Retardation and Psychomotor Development Delays of Children in Şanlıurfa, Turkey.

    Science.gov (United States)

    Yentur Doni, Nebiye; Yildiz Zeyrek, Fadile; Simsek, Zeynep; Gurses, Gulcan; Sahin, İbrahim

    2015-12-01

    The objective of this study was to determine the risk factors for and relationship among parasitic infections, growth retardation, and psychomotor developmental delays in children aged 6 years and below. This case-control study was performed in Şanlıurfa in southeastern Turkey between October and December 2007. Data were collected using a structured questionnaire, anthropometry, Ankara Development Screening Inventory, and laboratory analysis of stool specimens. The most common parasite was Giardia intestinalis (42.53%) followed by Enterobius vermicularis (27.58%), Ascaris lumbricoides (18.39%), Hymenolepis nana (5.75%), Trichuris trichiura (3.45%), Escherichia coli (1.15%), and Blastocystis spp. (1.15%). Fifty-eight percent of all children were infected with intestinal parasites; 55.2% had only one parasite, whereas 44.8% had multiple parasites. The children infected with G. intestinalis and other intestinal parasites had significantly higher levels of growth retardation and psychomotor development delay than non-infected children. Children with parasitic infections had growth delay up to 2.9 times, general development delay up to 1.9 times, language-cognitive development delay up to 2.2 times, and fine motor development delay up to 2.9 times higher than children without any parasitic infections. However, no significant relationship among intestinal parasites, gross motor development, social-self skills, and development delay was identified. The education level of parents, poor economic situation, number of households, not washing hands, playing with soil, family history of parasitic infection were the significant risk factors for intestinal parasites. Our study indicates that the presence of either malnutrition or intestinal parasites may put a child in a high-risk group for developmental delays and growth retardation. Therefore, public health interventions can embrace nationwide deworming in children.

  5. Focusing on dissociated motor development in Brazilian children

    OpenAIRE

    Minami, Maria Avanise Yumi; Funayama, Carolina A.R.; Daneluzzi, Julio Cesar

    2001-01-01

    Dissociated motor development (DMD) is considered when the baby starts independent walking late, with normality of the other fields of development. There is evidence that babies with DMD present an atypical crawling pattern and hypotonia. To investigate the frequency and characteristics of DMD, neurological examination was performed monthly in 177 healthy full-term babies from 6 months age, in urban and rural zone samples in Brazil. Among 20 children with atypical crawling, none presented hyp...

  6. Synchronous Spike Patterns in Macaque Motor Cortex during an Instructed-Delay Reach-to-Grasp Task.

    Science.gov (United States)

    Torre, Emiliano; Quaglio, Pietro; Denker, Michael; Brochier, Thomas; Riehle, Alexa; Grün, Sonja

    2016-08-10

    The computational role of spike time synchronization at millisecond precision among neurons in the cerebral cortex is hotly debated. Studies performed on data of limited size provided experimental evidence that low-order correlations occur in relation to behavior. Advances in electrophysiological technology to record from hundreds of neurons simultaneously provide the opportunity to observe coordinated spiking activity of larger populations of cells. We recently published a method that combines data mining and statistical evaluation to search for significant patterns of synchronous spikes in massively parallel spike trains (Torre et al., 2013). The method solves the computational and multiple testing problems raised by the high dimensionality of the data. In the current study, we used our method on simultaneous recordings from two macaque monkeys engaged in an instructed-delay reach-to-grasp task to determine the emergence of spike synchronization in relation to behavior. We found a multitude of synchronous spike patterns aligned in both monkeys along a preferential mediolateral orientation in brain space. The occurrence of the patterns is highly specific to behavior, indicating that different behaviors are associated with the synchronization of different groups of neurons ("cell assemblies"). However, pooled patterns that overlap in neuronal composition exhibit no specificity, suggesting that exclusive cell assemblies become active during different behaviors, but can recruit partly identical neurons. These findings are consistent across multiple recording sessions analyzed across the two monkeys. Neurons in the brain communicate via electrical impulses called spikes. How spikes are coordinated to process information is still largely unknown. Synchronous spikes are effective in triggering a spike emission in receiving neurons and have been shown to occur in relation to behavior in a number of studies on simultaneous recordings of few neurons. We recently published

  7. Shuttle Rocket Motor Program: NASA should delay awarding some construction contracts. Report to the Chair, Subcommittee on Government Activities and Transportation, Committee on Government Operations, House of Representatives

    Science.gov (United States)

    1992-01-01

    Even though the executive branch has proposed terminating the Advanced Solid Rocket Motor (ASRM) program, NASA is proceeding with all construction activity planned for FY 1992 to avoid schedule slippage if the program is reinstated by Congress. However, NASA could delay some construction activities for at least a few months without affecting the current launch data schedule. For example, NASA could delay Yellow Creek's motor storage and dock projects, Stennis' dock project, and Kennedy's rotation processing and surge facility and dock projects. Starting all construction activities as originally planned could result in unnecessarily incurring additional costs and termination liability if the funding for FY 1993 is not provided. If Congress decides to continue the program, construction could still be completed in time to avoid schedule slippage.

  8. A case of acutely developed delayed radiation myelopathy

    International Nuclear Information System (INIS)

    Hayashi, Shintaro; Amari, Masakuni; Fukuda, Toshio; Okamoto, Koichi

    2002-01-01

    A 66-year-old man with a history of hypertension received radiation therapy on his neck at age 61 because of laryngeal cancer (T1bN0M0). Five years after the radiation, he acutely developed dysuria, tetraparesis and dissociated sensory disturbances below bilateral Th4 level. T2 weighted MRI showed a high signal lesion affecting the central area of the spinal cord extending from C1 to C7. On the second clinical day, he developed respiratory arrest and was ventilated. The cerebrospinal fluid contained 20/mm 3 (monocyte 15, neutorophil 5) white cells; protein was 52.5 mg/dl; IgG index 0.54; Q albumin was 9.6; tests for oligoclonal band and myelin basic protein were negative; a culture yielded no microorganism. He was treated with steroids and supportive measures without improvement, and died of a sudden cardiac arrest on the 8th clinical day. postmortem examination confirmed conspicuous focal spongy changes with many axonal swellings, especially in the posterior and lateral columns at cervical and Th1 levels. The pathological findings were considered to be compatible with those of delayed radiation myelopathy (DRM). In the anterior horn of the cervical cord there were lesions of diffuse racification and the proliferation of small vessels. There were no findings of hyaline vascular changes, infarction or metastasis of laryngeal cancer at the spinal cord. It is considered that hyperintensity of signals on T2-weighted may originate from racification and proliferation of small vessels in the gray matter, and these pathological changes would be intimately associated with the severe neurologic morbidity of this patient. Acute development of neurological findings and the pathological changes in the gray matter of the spinal cord are rare manifestations of DRM. (author)

  9. Delayed Administration of VEGF Rescues Spinal Motor Neurons from Death with a Short Effective Time Frame in Excitotoxic Experimental Models in Vivo

    Directory of Open Access Journals (Sweden)

    Luis B Tovar-y-Romo

    2012-02-01

    Full Text Available VEGF (vascular endothelial growth factor prevents neuronal death in different models of ALS (amyotrophic lateral sclerosis, but few studies have addressed the efficacy of VEGF to protect motor neurons after the onset of symptoms, a critical point when considering VEGF as a potential therapeutic target for ALS. We studied the capability of VEGF to protect motor neurons after an excitotoxic challenge in two models of spinal neurodegeneration in rats induced by AMPA (α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid administered either chronically with osmotic minipumps or acutely by microdialysis. VEGF was administered through osmotic minipumps in the chronic model or injected intracerebroventricularly in the acute model, and its effects were assessed by immunohistochemical and histological analyses and motor performance tests. In the chronic model, VEGF stopped the progression of the paralysis and protected motor neurons when administered after AMPA before the onset of the motor symptoms, whereas no protection was observed when administered after the onset. VEGF was also protective in the acute model, but with a short time window, since the protection was effective when administered 1 h but not 2 h after AMPA. Our results indicate that while VEGF has an indubitable neuroprotective effect, its therapeutic potential for halting or delaying the progression of motor neuron loss in ALS would likely have a short effective time frame.

  10. A novel method for assessing the development of speech motor function in toddlers with autism spectrum disorders

    Directory of Open Access Journals (Sweden)

    Katherine eSullivan

    2013-03-01

    Full Text Available There is increasing evidence to show that indicators other than socio-cognitive abilities might predict communicative function in Autism Spectrum Disorders (ASD. A potential area of research is the development of speech motor function in toddlers. Utilizing a novel measure called ‘articulatory features’, we assess the abilities of toddlers to produce sounds at different timescales as a metric of their speech motor skills. In the current study, we examined 1 whether speech motor function differed between toddlers with ASD, developmental delay, and typical development; and 2 whether differences in speech motor function are correlated with standard measures of language in toddlers with ASD. Our results revealed significant differences between a subgroup of the ASD population with poor verbal skills, and the other groups for the articulatory features associated with the shortest time scale, namely place of articulation, (p<0.05. We also found significant correlations between articulatory features and language and motor ability as assessed by the Mullen and the Vineland scales for the ASD group. Our findings suggest that articulatory features may be an additional measure of speech motor function that could potentially be useful as an early risk indicator of ASD.

  11. Developments in delayed hydride cracking in zirconium alloys

    International Nuclear Information System (INIS)

    Puls, Manfred P.

    2008-01-01

    Delayed hydride cracking (DHC) is a process of diffusion assisted localized hydride embrittlement at flaws or regions of high stress. Models of DHC propagation and initiation have been developed that capture the essential elements of this phenomenon in terms of parameters describing processes occurring at the micro-scale. The models and their predictions of experimental results applied to Zr alloys are assessed. The propagation model allows rationalization of the effect of direction of approach to temperature and of the effect of the state and morphology of the beta phase in Zr-2.5Nb on DHC velocity. The K I dependence of the DHC velocity can only be approximately rationalized by the propagation models. This is thought to be because these models approximate the DHC velocity by a constant and shape-invariant rate of growth of the hydride at the flaw and have not incorporated a coupling between the applied stress field due to the flaw alone and the precipitated hydrides that would result in a variation of the shape and density of the hydrided region with K I . Separately, models have been developed for DHC initiation at cracks and blunt flaws. Expressions are obtained for the threshold stress intensity factor, K IH , for DHC initiation at a crack. A model for K IH has been used to rationalize the experimental result that DHC initiation is not possible above a certain temperature, even when hydrides can form at the crack tip. For blunt flaws with root radii in the μm range, and engineering process zone procedure has been derived to determine the initiation conditions requiring that both a critical stress and a critical flaw tip displacement must be achieved for hydride fracture. The engineering process zone procedure takes account of the dependence of DHC initiation on the flaw's root radius. Although all of the foregoing models are capable of describing the essential features of DHC, they are highly idealized and in need of further refinement. (author)

  12. Interaction between parental psychosis and early motor development and the risk of schizophrenia in a general population birth cohort.

    Science.gov (United States)

    Keskinen, E; Marttila, A; Marttila, R; Jones, P B; Murray, G K; Moilanen, K; Koivumaa-Honkanen, H; Mäki, P; Isohanni, M; Jääskeläinen, E; Miettunen, J

    2015-09-01

    Delayed motor development in infancy and family history of psychosis are both associated with increased risk of schizophrenia, but their interaction is largely unstudied. To investigate the association of the age of achieving motor milestones and parental psychosis and their interaction in respect to risk of schizophrenia. We used data from the general population-based prospective Northern Finland Birth Cohort 1966 (n=10,283). Developmental information of the cohort members was gathered during regular visits to Finnish child welfare clinics. Several registers were used to determine the diagnosis of schizophrenia among the cohort members and psychosis among the parents. Altogether 152 (1.5%) individuals had schizophrenia by the age of 46 years, with 23 (15.1%) of them having a parent with psychosis. Cox regression analysis was used in analyses. Parental psychosis was associated (Prisk for schizophrenia was increased if holding the head up (hazard ratio [HR]: 2.46; degrees of freedom [df]=1; 95% confidence interval [95% CI]: 1.07-5.66) and touching the thumb with the index finger (HR: 1.84; df=1; 95% CI: 1.11-3.06) was later. In the group without parental psychosis, a delay in the following milestones increased the risk of schizophrenia: standing without support and walking without support. Parental psychosis had an interaction with delayed touching thumb with index finger (HR: 1.87; df=1; 95% CI: 1.08-3.25) when risk of schizophrenia was investigated. Parental psychosis was associated with achieving motor milestones later in infancy, particularly the milestones that appear early in a child's life. Parental psychosis and touching the thumb with the index finger had a significant interaction on risk of schizophrenia. Genetic risk for psychosis may interact with delayed development to raise future risk of schizophrenia, or delayed development may be a marker of other risk processes that interact with genetic liability to cause later schizophrenia. Copyright © 2015

  13. Outcome and Process in Motor Performance: A Comparison of Jumping by Typically Developing Children and Those with Low Motor Proficiency

    Science.gov (United States)

    Williams, Morgan D.; Saunders, John E.; Maschette, Wayne E.; Wilson, Cameron J.

    2013-01-01

    The motivation for this study was to explore a conceptual framework to understand the outcomes and processes of motor performance in children. Vertical jumping, a fundamental movement skill, was used to compare children (ages 6-12 years) who were typically developing (TD) and those identified as having low motor proficiency (LMP). Jumps were…

  14. Follow-up of premature children with high risk for growth and development delay: a multiprofessional assessment

    Directory of Open Access Journals (Sweden)

    Marcia de Freitas

    2010-06-01

    Full Text Available Objective: To describe the activities of a multiprofessional outpatient clinic performed by neonatologist, physiatrist, physical therapist, occupational therapist, speech therapist, audiologist and psychologist, who evaluated the development of premature newborns. Methods: Twenty children born at a tertiary-care hospital (São Paulo, Brazil, between April 2006 and April 2007, with birth weight below 1250 g or less than 32 weeks of gestation, were evaluated. The multiprofessional evaluation included assessment of development using the Bayley III scale, at the corrected age of 3, 6, 9, 12, 18 and 24 months. Results: The mean gestation age at birth was 28.8 weeks; mean birth weight was 1055 g. The mean maternal age was 35 years and the mean length of stay of neonates was 46.3 days. Fifteen percent of children presented impaired sensory motor skills, 20% had hearing abnormalities and 10% motor alterations. Bayley III showed alterations in the communication area in 10% of subjects and in the motor area in 10% of individuals. The parents were oriented to stimulate the child or a specific intervention was suggested. The major development delay was observed between 6 and 18 months of age and the development was improved at 24 months of age. Conclusions: Most children evaluated had improved growth and development at 24 corrected-age months. Further studies with a larger sample are recommended, as well as the possibility to follow this population group up till the primary school.

  15. Drama for children with special needs (motor skill development)

    OpenAIRE

    Cameron, Fiona

    1991-01-01

    During placement in secondary schools, the author notice a general lack of confidence in the ability to use movement. Many of these "Clumsy Children" expressed difficulties with reading and writing and in the area of Mathematics. Was there a connection between under-developed motor skills and general academic and social behaviour? Primary 1-3 are structured around "learning by doing". After that the work changes to more cognitive based learning and more classroom structure. If the children do...

  16. Development of advanced diagnostic technologies for motor-operated valves

    International Nuclear Information System (INIS)

    Hegi, Kotaro; Shimizu, Shunichi; Higuma, Koji; Nishino, Koji; Osaki, Kenji; Watanabe, Kazumi; Hamano, Frank

    2010-01-01

    As use of condition-based maintenance is allowed in the new regulatory inspection system employed in Japan's nuclear power plants in 2009, development of advanced diagnostic technologies for motor-operated valves (MOVs) is now required. This report discusses advanced technologies in valve-setup verification, valve performance evaluation, monitoring of valve/actuator conditions by performance diagnostic system and moreover detection of stem crack by ultrasonic diagnostic system. (author)

  17. Object permanence development in infants with motor handicaps.

    Science.gov (United States)

    Fetters, L

    1981-03-01

    This study was an investigation of the effects of a motor handicap on the development of object permanence in the young child. Motor abilities were evaluated for 12 infants aged 13 to 29 months. Based on this evaluation, the children were described as manipulators or nonmanipulators in reference to their upper extremity skills. Their stage of object permanence was assessed using traditional and nontraditional assessments. Heart rate and visual tracking were recorded during the nontraditional assessment. Heart rate did not significantly relate to visual fixation or search response. There was, however, a significant difference (p less than .02) between stage achievement with traditional testing and age-appropriate levels. There was no significant difference between the nontraditional assessment and the age-appropriate levels. In addition, there was no significant difference in the development of object permanence between infants described as manipulators and those described as nonmanipulators. The last two findings suggest that infants with motor handicaps may develop object permanence at the expected ages, according to a nontraditional assessment.

  18. FreedomCAR Advanced Traction Drive Motor Development Phase I

    Energy Technology Data Exchange (ETDEWEB)

    Ley, Josh (UQM Technologies, Inc.); Lutz, Jon (UQM Technologies, Inc.)

    2006-09-01

    The overall objective of this program is to design and develop an advanced traction motor that will meet the FreedomCAR and Vehicle Technologies (FCVT) 2010 goals and the traction motor technical targets. The motor specifications are given in Section 1.3. Other goals of the program include providing a cost study to ensure the motor can be developed within the cost targets needed for the automotive industry. The program has focused on using materials that are both high performance and low costs such that the performance can be met and cost targets are achieved. In addition, the motor technologies and machine design features must be compatible with high volume manufacturing and able to provide high reliability, efficiency, and ruggedness while simultaneously reducing weight and volume. Weight and volume reduction will become a major factor in reducing cost, material cost being the most significant part of manufacturing cost at high volume. Many motor technology categories have been considered in the past and present for traction drive applications, including: brushed direct current (DC), PM (PM) brushless dc (BLDC), alternating current (AC) induction, switched reluctance and synchronous reluctance machines. Of these machine technologies, PM BLDC has consistently demonstrated an advantage in terms of power density and efficiency. As rare earth magnet cost has declined, total cost may also be reduced over the other technologies. Of the many different configurations of PM BLDC machines, those which incorporate power production utilizing both magnetic torque as well as reluctance torque appear to have the most promise for traction applications. There are many different PM BLDC machine configurations which employ both of these torque producing mechanisms; however, most would fall into one of two categories--some use weaker magnets and rely more heavily on reluctance torque (reluctance-dominant PM machines), others use strong PMs and supplement with reluctance torque

  19. Development of a linear induction motor based artificial muscle system.

    Science.gov (United States)

    Gruber, A; Arguello, E; Silva, R

    2013-01-01

    We present the design of a linear induction motor based on electromagnetic interactions. The engine is capable of producing a linear movement from electricity. The design consists of stators arranged in parallel, which produce a magnetic field sufficient to displace a plunger along its axial axis. Furthermore, the winding has a shell and cap of ferromagnetic material that amplifies the magnetic field. This produces a force along the length of the motor that is similar to that of skeletal muscle. In principle, the objective is to use the engine in the development of an artificial muscle system for prosthetic applications, but it could have multiple applications, not only in the medical field, but in other industries.

  20. Relationship between motor and cognitive development in children with developmental disabilities

    NARCIS (Netherlands)

    Houwen, Suzanne; Visser, Linda; van der Putten, Annette; Vlaskamp, Carla

    2014-01-01

    Background: There is an emerging body of evidence showing that motor and cognitive development are intertwined. However, little is known about (early) motor, cognitive, and language development in children with developmental disabilities. The aims of this study were to examine motor development in

  1. Developing language in a developing body: the relationship between motor development and language development*

    OpenAIRE

    Iverson, Jana M.

    2010-01-01

    During the first eighteen months of life, infants acquire and refine a whole set of new motor skills that significantly change the ways in which the body moves in and interacts with the environment. In this review article, I argue that motor acquisitions provide infants with an opportunity to practice skills relevant to language acquisition before they are needed for that purpose; and that the emergence of new motor skills changes infants’ experience with objects and people in ways that are r...

  2. CEREBELLUM: LINKS BETWEEN DEVELOPMENT, DEVELOPMENTAL DISORDERS AND MOTOR LEARNING

    Directory of Open Access Journals (Sweden)

    Mario U Manto

    2012-01-01

    Full Text Available The study of the links and interactions between development and motor learning has noticeable implications for the understanding and management of neurodevelopmental disorders. This is particularly relevant for the cerebellum which is critical for sensorimotor learning. The olivocerebellar pathway is a key pathway contributing to learning of motor skills. Its developmental maturation and remodelling are being unravelled. Advances in genetics have led to major improvements in our appraisal of the genes involved in cerebellar development, especially studies in mutant mice. Cerebellar neurogenesis is compartmentalized in relationship with neurotransmitter fate. The Engrailed-2 gene is a major actor of the specification of cerebellar cell types and late embryogenic morphogenesis. Math1, expressed by the rhombic lip (RL, is required for the genesis of glutamatergic neurons. Mutants deficient for the transcription factor Ptf1a display a lack of Purkinje cells and gabaergic interneurons. Rora gene contributes to the developmental signalling between granule cells and Purkinje neurons. The expression profile of SHH (Sonic hedgehog in postnatal stages determines the final size/shape of the cerebellum. Genes affecting the development impact upon the physiological properties of the cerebellar circuits. For instance, receptors are developmentally regulated and their action interferes directly with developmental processes. Another field of research which is expanding relates to very preterm neonates. They are at risk for cerebellar lesions, which may themselves impair the developmental events. Very preterm neonates often show sensori-motor deficits, highlighting another major link between impaired development and learning deficiencies. Pathways playing a critical role in cerebellar development are likely to become therapeutical targets for several neurodevelopmental disorders.

  3. The development of a screening tool to evaluate gross motor function in HIV-infected infants.

    Science.gov (United States)

    Hilburn, Nicole; Potterton, Joanne; Stewart, Aimee; Becker, Piet

    2011-12-01

    Neurodevelopmental delay or HIV encephalopathy is a stage four disease indicator for paediatric HIV/AIDS according to the World Health Organisation (WHO), and may be used as a criterion for initiation of highly active antiretroviral therapy (HAART). To date, the only means of prevention of this condition is early initiation of HAART. Studies which have been carried out in South African clinics have revealed the high prevalence of this condition. In developing countries, commencement of HAART is based on declining virologic and immunologic status, as standardised neurodevelopmental assessment tools are not widely available. A standardised developmental screening tool which is suitable for use in a developing country is therefore necessary in order to screen for neurodevelopmental delay to allow for further assessment and referral to rehabilitation services, as well as providing an additional assessment criterion for initiation of HAART. The infant gross motor screening test (IGMST) was developed for this purpose. The standardisation sample of the IGMST consisted of 112 HIV-infected infants between six and 18 months of age. Item selection for the IGMST was based on the Gross Motor scale of the Bayley Scales of Infant Development (BSID)-III. Content validity was assessed by a panel of experts using a nominal group technique (NGT; agreement >80%). Concurrent validity (n=60) of the IGMST was carried out against the BSID-III, and agreement was excellent (K=0.85). The diagnostic properties of the IGMST were evaluated and revealed: sensitivity 97.4%, specificity 85.7%, positive predictive value (PPV) 92.7%, and negative predictive value (NPV) 94.7%. Reliability testing (n=30) revealed inter-rater reliability as: r=1, test-retest reliability: r=0.98 and intra-rater reliability: r=0.98. The results indicate that the statistical properties of the IGMST are excellent, and the tool is suitable for use within the paediatric HIV setting.

  4. Delayed detection of motor pathway dysfunction after selective reduction of thoracic spinal cord blood flow in pigs

    NARCIS (Netherlands)

    Lips, Jeroen; de Haan, Peter; Bouma, Gerrit J.; Jacobs, Michael J.; Kalkman, Cor J.

    2002-01-01

    Objective: Clinical monitoring of myogenic motor evoked potentials to transcranial stimulation provides rapid evaluation of motor-pathway function during surgical procedures in which spinal cord ischemia can occur. However, a severe reduction of spinal cord blood flow that remains confined to the

  5. Developing Language in a Developing Body: The Relationship between Motor Development and Language Development

    Science.gov (United States)

    Iverson, Jana M.

    2010-01-01

    During the first eighteen months of life, infants acquire and refine a whole set of new motor skills that significantly change the ways in which the body moves in and interacts with the environment. In this review article, I argue that motor acquisitions provide infants with an opportunity to practice skills relevant to language acquisition before…

  6. Multiple intracerebroventricular injections of human umbilical cord mesenchymal stem cells delay motor neurons loss but not disease progression of SOD1G93A mice.

    Science.gov (United States)

    Sironi, Francesca; Vallarola, Antonio; Violatto, Martina Bruna; Talamini, Laura; Freschi, Mattia; De Gioia, Roberta; Capelli, Chiara; Agostini, Azzurra; Moscatelli, Davide; Tortarolo, Massimo; Bigini, Paolo; Introna, Martino; Bendotti, Caterina

    2017-12-01

    Stem cell therapy is considered a promising approach in the treatment of amyotrophic lateral sclerosis (ALS) and mesenchymal stem cells (MSCs) seem to be the most effective in ALS animal models. The umbilical cord (UC) is a source of highly proliferating fetal MSCs, more easily collectable than other MSCs. Recently we demonstrated that human (h) UC-MSCs, double labeled with fluorescent nanoparticles and Hoechst-33258 and transplanted intracerebroventricularly (ICV) into SOD1G93A transgenic mice, partially migrated into the spinal cord after a single injection. This prompted us to assess the effect of repeated ICV injections of hUC-MSCs on disease progression in SOD1G93A mice. Although no transplanted cells migrated to the spinal cord, a partial but significant protection of motor neurons (MNs) was found in the lumbar spinal cord of hUC-MSCs-treated SOD1G93A mice, accompanied by a shift from a pro-inflammatory (IL-6, IL-1β) to anti-inflammatory (IL-4, IL-10) and neuroprotective (IGF-1) environment in the lumbar spinal cord, probably linked to the activation of p-Akt survival pathway in both motor neurons and reactive astrocytes. However, this treatment neither prevented the muscle denervation nor delayed the disease progression of mice, emphasizing the growing evidence that protecting the motor neuron perikarya is not sufficient to delay the ALS progression. Copyright © 2017. Published by Elsevier B.V.

  7. Formulation, Development and Evaluation of delayed release capsules of Duloxetine Hydrochloride made of different Enteric Polymers

    OpenAIRE

    Pallavi Yerramsetty; J. Vijaya Ratna; Venkata Ramana Reddy; Praveen Kumar

    2012-01-01

    Delayed release systems have acquired a centre stage in the arena of pharmaceutical research and development. The present study involves formulation and evaluation of Duloxetine Hydrochloride delayed release capsules. Duloxetine Hydrochloride is an acid labile drug. It degrades in the acidic environment of the stomach thus leading to therapeutic inefficacy. Therefore it is necessary to bypass the acidic pH of the stomach which can be achieved by formulating delayed release dosage form by usin...

  8. Development of Young Adults' Fine Motor Skills when Learning to Play Percussion Instruments

    Science.gov (United States)

    Gzibovskis, Talis; Marnauza, Mara

    2012-01-01

    When playing percussion instruments, the main activity is done with the help of a motion or motor skills; to perform it, developed fine motor skills are necessary: the speed and precision of fingers, hands and palms. The aim of the research was to study and test the development of young adults' fine motor skills while learning to play percussion…

  9. Gross Motor Development of Malaysian Hearing Impaired Male Pre- and Early School Children

    Science.gov (United States)

    Zawi, Khairi; Lian, Denise Koh Choon; Abdullah, Rozlina Tan

    2014-01-01

    Acquisition of gross motor skill is a natural developmental process for children. This aspect of human development increases with one's chronological age, irrespective of any developmental conditions. The purpose of this study was to assess the level of gross motor skill development among pre- and early school-aged children with motor disability.…

  10. Development of a Portable Motor Learning Laboratory (PoMLab).

    Science.gov (United States)

    Takiyama, Ken; Shinya, Masahiro

    2016-01-01

    Most motor learning experiments have been conducted in a laboratory setting. In this type of setting, a huge and expensive manipulandum is frequently used, requiring a large budget and wide open space. Subjects also need to travel to the laboratory, which is a burden for them. This burden is particularly severe for patients with neurological disorders. Here, we describe the development of a novel application based on Unity3D and smart devices, e.g., smartphones or tablet devices, that can be used to conduct motor learning experiments at any time and in any place, without requiring a large budget and wide open space and without the burden of travel on subjects. We refer to our application as POrtable Motor learning LABoratory, or PoMLab. PoMLab is a multiplatform application that is available and sharable for free. We investigated whether PoMLab could be an alternative to the laboratory setting using a visuomotor rotation paradigm that causes sensory prediction error, enabling the investigation of how subjects minimize the error. In the first experiment, subjects could adapt to a constant visuomotor rotation that was abruptly applied at a specific trial. The learning curve for the first experiment could be modeled well using a state space model, a mathematical model that describes the motor leaning process. In the second experiment, subjects could adapt to a visuomotor rotation that gradually increased each trial. The subjects adapted to the gradually increasing visuomotor rotation without being aware of the visuomotor rotation. These experimental results have been reported for conventional experiments conducted in a laboratory setting, and our PoMLab application could reproduce these results. PoMLab can thus be considered an alternative to the laboratory setting. We also conducted follow-up experiments in university physical education classes. A state space model that was fit to the data obtained in the laboratory experiments could predict the learning curves

  11. Development of a Portable Motor Learning Laboratory (PoMLab.

    Directory of Open Access Journals (Sweden)

    Ken Takiyama

    Full Text Available Most motor learning experiments have been conducted in a laboratory setting. In this type of setting, a huge and expensive manipulandum is frequently used, requiring a large budget and wide open space. Subjects also need to travel to the laboratory, which is a burden for them. This burden is particularly severe for patients with neurological disorders. Here, we describe the development of a novel application based on Unity3D and smart devices, e.g., smartphones or tablet devices, that can be used to conduct motor learning experiments at any time and in any place, without requiring a large budget and wide open space and without the burden of travel on subjects. We refer to our application as POrtable Motor learning LABoratory, or PoMLab. PoMLab is a multiplatform application that is available and sharable for free. We investigated whether PoMLab could be an alternative to the laboratory setting using a visuomotor rotation paradigm that causes sensory prediction error, enabling the investigation of how subjects minimize the error. In the first experiment, subjects could adapt to a constant visuomotor rotation that was abruptly applied at a specific trial. The learning curve for the first experiment could be modeled well using a state space model, a mathematical model that describes the motor leaning process. In the second experiment, subjects could adapt to a visuomotor rotation that gradually increased each trial. The subjects adapted to the gradually increasing visuomotor rotation without being aware of the visuomotor rotation. These experimental results have been reported for conventional experiments conducted in a laboratory setting, and our PoMLab application could reproduce these results. PoMLab can thus be considered an alternative to the laboratory setting. We also conducted follow-up experiments in university physical education classes. A state space model that was fit to the data obtained in the laboratory experiments could predict the

  12. THE ROLE OF DYNAMIC SYSTEMS IN MOTOR DEVELOPMENT RESEARCH. JUST A METAPHOR OR A NOTABLE REALITY?

    OpenAIRE

    Ivan Šerbetar

    2015-01-01

    In the present article an application of a new theory of motor control in the context of motor development theories and research has been discussed. In a brief overview of traditional theories of motor development a neuro-maturational theory is mentioned along with the two prominent proponents - McGraw & Gesell. Bernstein’s fundamental insights in motor control were emphasized, such as the concepts of degrees of freedom and synergies, along with his contribution to the measurement technology ...

  13. Effectiveness of the teaching of perceptual-motor practices and rhythmic movement on motor development in children with intellectual disability

    Directory of Open Access Journals (Sweden)

    Behrouz Ghorban Zadeh

    2015-10-01

    Full Text Available Objective: Fundamental motor skills are the foundation of special skills. The purpose of this study was to study the effectiveness of the teaching of perceptual-motor practices and rhythmic movement on motor development in children with intellectual disability. Materials & Methods: In this quasi-excremental study, 30 children aged 7 to 10 years old were selected through random cluster sampling method from elementary schools in Tabriz city. They were homogenized in two experimental groups (perceptual-motor practices and rhythmic movement and one control group based on their age and IQ. Programs were held in 9 weeks, two sessions per week, and each session was 45 minutes. Before beginning the training and at the end of the last session, pre-test and post-test were conducted. In order to assess motor development TGMD-2 test was used, and to analyze data covariance and bonferroni postdoc test were used. Results: The results showed that both perceptual-motor practices and rhythmic movement groups performed better in locomotors and object control skills than the control group (P&le 0.05 and there was no significant difference between these two groups  (P&ge0.05Perceptual-motor skills training group had a greater impact on the development of control object skills than rhythmic movement group. Program rhythmic movement group had a greater impact on the development of object control skills than the control group. Conclusion: According to the results, educational programs which are used can be as an appropriate experiencing motion for children. These programs can be used at schools to to provide suitable program and the opportunity for training and developing motor skills.

  14. Impact of Vitamin D Supplementation on Gross Motor Development of Healthy Term Infants: A Randomized Dose-Response Trial.

    Science.gov (United States)

    Wicklow, Brandy; Gallo, Sina; Majnemer, Annette; Vanstone, Catherine; Comeau, Kathryn; Jones, Glenville; L'Abbe, Mary; Khamessan, Ali; Sharma, Atul; Weiler, Hope; Rodd, Celia

    2016-08-01

    In addition to benefits for bone health, vitamin D is implicated in muscle function in children and adults. To determine if vitamin D dosage positively correlated with gross motor development at 3 and 6 months of age. We hypothesized that higher doses would be associated with higher scores for gross motor skills. A consecutive sample of 55 healthy, term, and breastfed infants from Montreal, Canada were recruited from a randomized trial of vitamin D supplementation between 2009 and 2012. Infants were randomized to 400 International Units (IU) (n = 19), 800 IU (n = 18) or 1,200 IU (n = 18) vitamin D3/day. Motor performance at 3 and 6 months was quantified by the Alberta Infant Motor Scale (AIMS). Plasma vitamin D3 metabolites were measured by tandem mass spectrometry. AIMS scores did not differ at 3 months. However, total AIMS scores and sitting subscores were significantly higher at 6 months in infants receiving 400 IU/day compared to 800 IU/day and 1,200 IU/day groups (p gross motor achievements were significantly higher in infants receiving 400 IU/day vitamin D. Our findings also support longer infants being slightly delayed.

  15. The role of older siblings in infant motor development

    OpenAIRE

    Leonard, Hayley; Hill, EL

    2016-01-01

    Previous research has suggested that infant motor skills may be affected by older siblings, but has not considered whether this is due to specific characteristics of the older sibling, or of the quality of the sibling relationship. The current study used a longitudinal diary method to record infant motor milestones from 23 infants with older siblings, along with parent reports and standardised assessments of motor skills. Parent reports of the older siblings’ motor skills and the sibling rela...

  16. Wheel running from a juvenile age delays onset of specific motor deficits but does not alter protein aggregate density in a mouse model of Huntington's disease

    Directory of Open Access Journals (Sweden)

    Spires Tara L

    2008-04-01

    Full Text Available Abstract Background Huntington's disease (HD is a neurodegenerative disorder predominantly affecting the cerebral cortex and striatum. Transgenic mice (R6/1 line, expressing a CAG repeat encoding an expanded polyglutamine tract in the N-terminus of the huntingtin protein, closely model HD. We have previously shown that environmental enrichment of these HD mice delays the onset of motor deficits. Furthermore, wheel running initiated in adulthood ameliorates the rear-paw clasping motor sign, but not an accelerating rotarod deficit. Results We have now examined the effects of enhanced physical activity via wheel running, commenced at a juvenile age (4 weeks, with respect to the onset of various behavioral deficits and their neuropathological correlates in R6/1 HD mice. HD mice housed post-weaning with running wheels only, to enhance voluntary physical exercise, have delayed onset of a motor co-ordination deficit on the static horizontal rod, as well as rear-paw clasping, although the accelerating rotarod deficit remains unaffected. Both wheel running and environmental enrichment rescued HD-induced abnormal habituation of locomotor activity and exploratory behavior in the open field. We have found that neither environment enrichment nor wheel running ameliorates the shrinkage of the striatum and anterior cingulate cortex (ACC in HD mice, nor the overall decrease in brain weight, measured at 9 months of age. At this age, the density of ubiquitinated protein aggregates in the striatum and ACC is also not significantly ameliorated by environmental enrichment or wheel running. Conclusion These results indicate that enhanced voluntary physical activity, commenced at an early presymptomatic stage, contributes to the positive effects of environmental enrichment. However, sensory and cognitive stimulation, as well as motor stimulation not associated with running, may constitute major components of the therapeutic benefits associated with enrichment

  17. Genetic deficiency of GABA differentially regulates respiratory and non-respiratory motor neuron development.

    Directory of Open Access Journals (Sweden)

    Matthew J Fogarty

    Full Text Available Central nervous system GABAergic and glycinergic synaptic activity switches from postsynaptic excitation to inhibition during the stage when motor neuron numbers are being reduced, and when synaptic connections are being established onto and by motor neurons. In mice this occurs between embryonic (E day 13 and birth (postnatal day 0. Our previous work on mice lacking glycinergic transmission suggested that altered motor neuron activity levels correspondingly regulated motor neuron survival and muscle innervation for all respiratory and non respiratory motor neuron pools, during this period of development [1]. To determine if GABAergic transmission plays a similar role, we quantified motor neuron number and the extent of muscle innervation in four distinct regions of the brain stem and spinal cord; hypoglossal, phrenic, brachial and lumbar motor pools, in mice lacking the enzyme GAD67. These mice display a 90% drop in CNS GABA levels ( [2]; this study. For respiratory-based motor neurons (hypoglossal and phrenic motor pools, we have observed significant drops in motor neuron number (17% decline for hypoglossal and 23% decline for phrenic and muscle innervations (55% decrease. By contrast for non-respiratory motor neurons of the brachial lateral motor column, we have observed an increase in motor neuron number (43% increase and muscle innervations (99% increase; however for more caudally located motor neurons within the lumbar lateral motor column, we observed no change in either neuron number or muscle innervation. These results show in mice lacking physiological levels of GABA, there are distinct regional changes in motor neuron number and muscle innervation, which appear to be linked to their physiological function and to their rostral-caudal position within the developing spinal cord. Our results also suggest that for more caudal (lumbar regions of the spinal cord, the effect of GABA is less influential on motor neuron development compared to

  18. Impact of a Community-Based Programme for Motor Development on Gross Motor Skills and Cognitive Function in Preschool Children from Disadvantaged Settings

    Science.gov (United States)

    Draper, Catherine E.; Achmat, Masturah; Forbes, Jared; Lambert, Estelle V.

    2012-01-01

    The aims of the studies were to assess the impact of the Little Champs programme for motor development on (1) the gross motor skills, and (2) cognitive function of children in the programme. In study 1, 118 children from one Early Childhood Development Centre (ECDC) were tested using the Test of Gross Motor Development-2, and in study 2, 83…

  19. [Stimulation at home and motor development among 36-month-old Mexican children].

    Science.gov (United States)

    Osorio, Erika; Torres-Sánchez, Luisa; Hernández, María Del Carmen; López-Carrillo, Lizbeth; Schnaas, Lourdes

    2010-01-01

    To identify the relationship between stimulation at home and motor development among 36 month-old children. The development of gross and fine motor skills of 169 infants (50.9% boys and 49.1% girls) was assessed at the age of 36 months with the Peabody Developmental Motor Scale. The quality of home stimulation was determined during a prior evaluation (at 30 months) by means of the HOME Scale. Total stimulation at home was significantly associated with better performance in the gross and fine motor areas. Particular aspects of this home stimulation were related to better gross and fine motor functions. Static balance and locomotion (gross motor skills) and grasping and visual-motor integration (fine motor skills) are associated with particular aspects of home stimulation, such as parent-child interaction, verbal reinforcement of the child's positive actions and providing the child with clear boundaries.

  20. Early motor development and later language and reading skills in children at risk of familial dyslexia.

    Science.gov (United States)

    Viholainen, Helena; Ahonen, Timo; Lyytinen, Paula; Cantell, Marja; Tolvanen, Asko; Lyytinen, Heikki

    2006-05-01

    Relationships between early motor development and language and reading skills were studied in 154 children, of whom 75 had familial risk of dyslexia (37 females, 38 males; at-risk group) and 79 constituted a control group (32 females, 47 males). Motor development was assessed by a structured parental questionnaire during the child's first year of life. Vocabulary and inflectional morphology skills were used as early indicators of language skills at 3 years 6 months and 5 years or 5 years 6 months of age, and reading speed was used as a later indicator of reading skills at 7 years of age. The same subgroups as in our earlier study (in which the cluster analysis was described) were used in this study. The three subgroups of the control group were 'fast motor development', 'slow fine motor development', and 'slow gross motor development', and the two subgroups of the at-risk group were 'slow motor development' and 'fast motor development'. A significant difference was found between the development of expressive language skills. Children with familial risk of dyslexia and slow motor development had a smaller vocabulary with poorer inflectional skills than the other children. They were also slower in their reading speed at the end of the first grade at the age of 7 years. Two different associations are discussed, namely the connection between early motor development and language development, and the connection between early motor development and reading speed.

  1. A Direct Comparison of Self-Injurious and Stereotyped Motor Behavior Between Preschool-Aged Children With and Without Developmental Delays.

    Science.gov (United States)

    Hoch, John; Spofford, Lisa; Dimian, Adele; Tervo, Raymond; MacLean, William E; Symons, Frank J

    2016-06-01

    To compare the prevalence of self-injurious behavior (SIB) and stereotyped motor behavior (STY) of preschool-aged children with developmental delays (DD group) and their peers without developmental delays (TD group) using a standardized caregiver report scale. The Repetitive Behavior Scale-Revised was completed by caregivers of children with developmental delays and their peers without developmental delays. Frequency of occurrence and severity ratings for SIB and STY were compared between groups. SIB and STY were reported more often and at a greater level of severity in the DD group. Older chronological age was associated with more severe STY in the DD group but not the TD group. Gender was not related to STY or SIB for either group. Differences in STY and SIB were evident between preschoolers with and without DD. Findings are discussed from developmental and behavioral psychology perspectives regarding the expression of repetitive behavior in developmentally at-risk pediatric populations. © The Author 2015. Published by Oxford University Press on behalf of the Society of Pediatric Psychology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  2. Development and evaluation of the psychometric properties of the Adolescent Motor Competence Questionnaire (AMCQ) for Adolescents.

    NARCIS (Netherlands)

    Timler, Amanda; McIntyre, Fleur; Cantell, Marja; Crawford, Susan; Hands, Beth

    2016-01-01

    Background: There are no valid and reliable self-report measures designed to identify levelof motor competence and suspected motor difficulties among 12–18 year old adolescents.Aim: This paper reports the development and evaluation of a self-report questionnaire(Adolescent Motor Competence

  3. Attainment of gross motor milestones by preterm children with normal development upon school entry

    NARCIS (Netherlands)

    van Dokkum, Nienke H; de Kroon, Marlou L A; Bos, Arend F; Reijneveld, Sijmen A; Kerstjens, Jorien M

    BACKGROUND: Little is known on the motor development of moderately preterm born (MPT) children, in comparison with early preterm born (EPT) children and fullterm born (FT), for children with normal motor outcomes at school entry. AIMS: To compare attainment rates of gross motor milestones reached

  4. DISTURBANCE OF NORMAL MOTOR DEVELOPMENT IN THE FIRST YEAR OF LIFE

    OpenAIRE

    Lidija Dimitrijević; Hristina Čolović

    2005-01-01

    The adoption of the basic motor skills in the first year of life (postural head control, lateral transfers into a lying position, sitting, standing, walking, crawling, grasping...) goes on quite spontaneously. A child learns all the motor actions by itself and that is why it is not necessary to “teach” a child to seat, grasp, stand, walk... Teaching a child the basic motor skills stands for a rough, unnecessary and undesirable involvement into spontaneous motor development, and, due to this, ...

  5. Motor development during the first year: a comparative study.

    Science.gov (United States)

    Santos, D C; Gabbard, C; Goncalves, V M

    2001-06-01

    This investigation of the motor development characteristics of Brazilian infants during the 1st year of postnatal life compared the findings with those of a widely used U.S. sample (N. Bayley, 1993). Analysis of the 12 monthly assessments indicated that Brazilian infants' scores increased with age, with the greatest increase occurring over the first 8 months. As a general comparison, the results are similar to the U.S. patterns of development. However, the Brazilian sample exhibited mean scores significantly lower than the U.S. sample's in the 3rd, 4th, and 5th months. More specific analyses indicated that the difference within these months was on tasks of sitting and grasping. Possible explanations for the differences focus on variations in child-rearing practices and the influence of biological maturation in early movement behaviors.

  6. Focusing on dissociated motor development in Brazilian children

    Directory of Open Access Journals (Sweden)

    Minami Maria Avanise Yumi

    2001-01-01

    Full Text Available Dissociated motor development (DMD is considered when the baby starts independent walking late, with normality of the other fields of development. There is evidence that babies with DMD present an atypical crawling pattern and hypotonia. To investigate the frequency and characteristics of DMD, neurological examination was performed monthly in 177 healthy full-term babies from 6 months age, in urban and rural zone samples in Brazil. Among 20 children with atypical crawling, none presented hypotonia neither did they start independent walking late. The means of the ages at the begining of atypical crawling and independent walking acquisitions, 7.40mo (SD 1.4 and 12.76mo (SD 2.5 respectively, did not differ from the group with crossed crawling pattern. Thus, in this sample of Brazilian healthy children we did not find cases with DMD.

  7. Motor fuel taxation, energy conservation, and economic development: A regional approach

    International Nuclear Information System (INIS)

    England, Richard W.

    2007-01-01

    Combustion of motor fuels has a variety of environmental impacts on local, regional and global scales. Taxing motor fuels more heavily would mitigate those environmental impacts. However, many governments are reluctant to increase motor fuel taxes because they fear that the tax incidence will be regressive and that economic development will be impeded. Using data for the New England region of the United States, this paper argues that an oil-importing region can conserve energy, avoid regressive impacts and encourage economic development by taxing motor fuels more heavily and rebating the incremental revenues to owners of motor vehicles. (author)

  8. Edaravone, a Free Radical Scavenger, Delayed Symptomatic and Pathological Progression of Motor Neuron Disease in the Wobbler Mouse.

    Directory of Open Access Journals (Sweden)

    Ken Ikeda

    Full Text Available Edaravone, a free radical scavenger is used widely in Japanese patients with acute cerebral infarction. This antioxidant could have therapeutic potentials for other neurological diseases. Amyotrophic lateral sclerosis (ALS is a fatal neurodegenerative disease that affects the upper and the lower motor neuron, leading to death within 3-5 years after onset. A phase III clinical trial of edaravone suggested no significant effects in ALS patients. However, recent 2nd double-blind trial has demonstrated therapeutic benefits of edaravone in definite patients diagnosed by revised El Escorial diagnostic criteria of ALS. Two previous studies showed that edaravone attenuated motor symptoms or motor neuron degeneration in mutant superoxide dismutase 1-transgenic mice or rats, animal models of familial ALS. Herein we examined whether this radical scavenger can retard progression of motor dysfunction and neuropathological changes in wobbler mice, sporadic ALS-like model. After diagnosis of the disease onset at the postnatal age of 3-4 weeks, wobbler mice received edaravone (1 or 10 mg/kg, n = 10/group or vehicle (n = 10, daily for 4 weeks by intraperitoneal administration. Motor symptoms and neuropathological changes were compared among three groups. Higher dose (10 mg/kg of edaravone treatment significantly attenuated muscle weakness and contracture in the forelimbs, and suppressed denervation atrophy in the biceps muscle and degeneration in the cervical motor neurons compared to vehicle. Previous and the present studies indicated neuroprotective effects of edaravone in three rodent ALS-like models. This drug seems to be worth performing the clinical trial in ALS patients in the United States of American and Europe, in addition to Japan.

  9. Edaravone, a Free Radical Scavenger, Delayed Symptomatic and Pathological Progression of Motor Neuron Disease in the Wobbler Mouse.

    Science.gov (United States)

    Ikeda, Ken; Iwasaki, Yasuo

    2015-01-01

    Edaravone, a free radical scavenger is used widely in Japanese patients with acute cerebral infarction. This antioxidant could have therapeutic potentials for other neurological diseases. Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that affects the upper and the lower motor neuron, leading to death within 3-5 years after onset. A phase III clinical trial of edaravone suggested no significant effects in ALS patients. However, recent 2nd double-blind trial has demonstrated therapeutic benefits of edaravone in definite patients diagnosed by revised El Escorial diagnostic criteria of ALS. Two previous studies showed that edaravone attenuated motor symptoms or motor neuron degeneration in mutant superoxide dismutase 1-transgenic mice or rats, animal models of familial ALS. Herein we examined whether this radical scavenger can retard progression of motor dysfunction and neuropathological changes in wobbler mice, sporadic ALS-like model. After diagnosis of the disease onset at the postnatal age of 3-4 weeks, wobbler mice received edaravone (1 or 10 mg/kg, n = 10/group) or vehicle (n = 10), daily for 4 weeks by intraperitoneal administration. Motor symptoms and neuropathological changes were compared among three groups. Higher dose (10 mg/kg) of edaravone treatment significantly attenuated muscle weakness and contracture in the forelimbs, and suppressed denervation atrophy in the biceps muscle and degeneration in the cervical motor neurons compared to vehicle. Previous and the present studies indicated neuroprotective effects of edaravone in three rodent ALS-like models. This drug seems to be worth performing the clinical trial in ALS patients in the United States of American and Europe, in addition to Japan.

  10. Malnutrition and Its Determinants Are Associated with Suboptimal Cognitive, Communication, and Motor Development in Tanzanian Children.

    Science.gov (United States)

    Sudfeld, Christopher R; McCoy, Dana Charles; Fink, Günther; Muhihi, Alfa; Bellinger, David C; Masanja, Honorati; Smith, Emily R; Danaei, Goodarz; Ezzati, Majid; Fawzi, Wafaie W

    2015-12-01

    A large volume of literature has shown negative associations between stunting and child development; however, there is limited evidence for associations with milder forms of linear growth faltering and determinants of malnutrition in developing countries. The objective of this study was to assess the association between anthropometric growth indicators across their distribution and determinants of malnutrition with development of Tanzanian children. We used the Bayley Scales of Infant Development III to assess a cohort of 1036 Tanzanian children between 18 and 36 mo of age who were previously enrolled in a neonatal vitamin A trial. Linear regression models were used to assess standardized mean differences in child development for anthropometry z scores, along with pregnancy, delivery, and early childhood factors. Height-for-age z score (HAZ) was linearly associated with cognitive, communication, and motor development z scores across the observed range in this population (all P values for linear relation malnutrition was associated with increasing developmental deficits in Tanzanian children, whereas only wasted children exhibited developmental delays during acute malnutrition. Interventions to reduce SGA, improve sanitation, and increase maternal stature may have positive effects on child development. This trial was registered with the Australian New Zealand Clinical Trials Registry as ACTRN12610000636055. © 2015 American Society for Nutrition.

  11. The effect of height, weight and head circumference on gross motor development in achondroplasia.

    Science.gov (United States)

    Ireland, Penelope Jane; Ware, Robert S; Donaghey, Samantha; McGill, James; Zankl, Andreas; Pacey, Verity; Ault, Jenny; Savarirayan, Ravi; Sillence, David; Thompson, Elizabeth; Townshend, Sharron; Johnston, Leanne M

    2013-02-01

    This study aimed to investigate whether height, weight, head circumference and/or relationships between these factors are associated with gross motor milestone acquisition in children with achondroplasia. Population-based data regarding timing of major gross motor milestones up to 5 years were correlated with height, weight and head circumference at birth and 12 months in 48 children with achondroplasia born in Australia and New Zealand between 2000 and 2009. Although as a group children with achondroplasia showed delayed gross motor skill acquisition, within group differences in height, weight or head circumference did not appear to influence timing of gross motor skills before 5 years. The exception was lie to sit transitioning, which appears likely to occur earlier if the child is taller and heavier at 12 months, and later if the child has significant head-to-body disproportion. This is the first study to investigate the relationship between common musculoskeletal impairments associated with achondroplasia and timing of gross motor achievement. Identification of the musculoskeletal factors that exacerbate delays in transitioning from lying to sitting will assist clinicians to provide more proactive assessment, advice and intervention regarding motor skill acquisition for this population. © 2013 The Authors. Journal of Paediatrics and Child Health © 2013 Paediatrics and Child Health Division (Royal Australasian College of Physicians).

  12. Leaf development and photosynthetic properties of three tropical tree species with delayed greening

    NARCIS (Netherlands)

    Cai, Z.Q.; Slot, M.; Fan, Z.X.

    2005-01-01

    Leaf developmental patterns were characterized for three tropical tree species with delayed greening. Changes in the pigment contents, photosynthetic capacity, stomata development, photosystem 2 efficiency, rate of energy dissipation, and the activity of partial protective enzymes were followed in

  13. Mechanisms of motor recovery after subtotal spinal cord injury: insights from the study of mice carrying a mutation (WldS) that delays cellular responses to injury.

    Science.gov (United States)

    Zhang, Z; Guth, L; Steward, O

    1998-01-01

    Partial lesions of the mammalian spinal cord result in an immediate motor impairment that recovers gradually over time; however, the cellular mechanisms responsible for the transient nature of this paralysis have not been defined. A unique opportunity to identify those injury-induced cellular responses that mediate the recovery of function has arisen from the discovery of a unique mutant strain of mice in which the onset of Wallerian degeneration is dramatically delayed. In this strain of mice (designated WldS for Wallerian degeneration, slow), many of the cellular responses to spinal cord injury are also delayed. We have used this experimental animal model to evaluate possible causal relationships between these delayed cellular responses and the onset of functional recovery. For this purpose, we have compared the time course of locomotor recovery in C57BL/6 (control) mice and in WldS (mutant) mice by hemisecting the spinal cord at T8 and evaluating locomotor function at daily postoperative intervals. The time course of locomotor recovery (as determined by the Tarlov open-field walking procedure) was substantially delayed in mice carrying the WldS mutation: C57BL/6 control mice began to stand and walk within 6 days (mean Tarlov score of 4), whereas mutant mice did not exhibit comparable locomotor function until 16 days postoperatively. (a) The rapid return of locomotor function in the C57BL/6 mice suggests that the recovery resulted from processes of functional plasticity rather than from regeneration or collateral sprouting of nerve fibers. (b) The marked delay in the return of locomotor function in WldS mice indicates that the processes of neuroplasticity are induced by degenerative changes in the damaged neurons. (c) These strains of mice can be effectively used in future studies to elucidate the specific biochemical and physiological alterations responsible for inducing functional plasticity and restoring locomotor function after spinal cord injury.

  14. Contribution of parenting to complex syntax development in preschool children with developmental delays or typical development.

    Science.gov (United States)

    Moody, C T; Baker, B L; Blacher, J

    2018-05-10

    Despite studies of how parent-child interactions relate to early child language development, few have examined the continued contribution of parenting to more complex language skills through the preschool years. The current study explored how positive and negative parenting behaviours relate to growth in complex syntax learning from child age 3 to age 4 years, for children with typical development or developmental delays (DDs). Participants were children with or without DD (N = 60) participating in a longitudinal study of development. Parent-child interactions were transcribed and coded for parenting domains and child language. Multiple regression analyses were used to identify the contribution of parenting to complex syntax growth in children with typical development or DD. Analyses supported a final model, F(9,50) = 11.90, P < .001, including a significant three-way interaction between positive parenting behaviours, negative parenting behaviours and child delay status. This model explained 68.16% of the variance in children's complex syntax at age 4. Simple two-way interactions indicated differing effects of parenting variables for children with or without DD. Results have implications for understanding of complex syntax acquisition in young children, as well as implications for interventions. © 2018 MENCAP and International Association of the Scientific Study of Intellectual and Developmental Disabilities and John Wiley & Sons Ltd.

  15. Gross motor development and physical activity in kindergarten age children.

    Science.gov (United States)

    Colella, Dario; Morano, Milena

    2011-10-01

    Physical activity in kindergarten is a fundamental part of the child's educational process. Body experience and physical activity contribute to the development of self-awareness and the learning of different modes of expression, as well as encouraging the acquisition of physically active lifestyles. Recent scientific evidence has confirmed the role of physical activity in disease prevention and quality of life improvement, and stressed the importance of integrated educational programmes promoting physical activity and healthy eating habits. A key priority of scientific research is to identify the opportunities and methods of motor learning and to increase the daily physical activity levels of children by reducing sedentary time and promoting active play and transport (i.e. walking, cycling). Family, school and community involvement are all needed to assure adherence to the official guidelines on how much physical activity children need to boost their health and stave off obesity.

  16. The effects of perceived USB-delay for sensor and embedded system development.

    Science.gov (United States)

    Du, J; Kade, D; Gerdtman, C; Ozcan, O; Linden, M

    2016-08-01

    Perceiving delay in computer input devices is a problem which gets even more eminent when being used in healthcare applications and/or in small, embedded systems. Therefore, the amount of delay found as acceptable when using computer input devices was investigated in this paper. A device was developed to perform a benchmark test for the perception of delay. The delay can be set from 0 to 999 milliseconds (ms) between a receiving computer and an available USB-device. The USB-device can be a mouse, a keyboard or some other type of USB-connected input device. Feedback from performed user tests with 36 people form the basis for the determination of time limitations for the USB data processing in microprocessors and embedded systems without users' noticing the delay. For this paper, tests were performed with a personal computer and a common computer mouse, testing the perception of delays between 0 and 500 ms. The results of our user tests show that perceived delays up to 150 ms were acceptable and delays larger than 300 ms were not acceptable at all.

  17. Development of kinesthetic-motor and auditory-motor representations in school-aged children.

    Science.gov (United States)

    Kagerer, Florian A; Clark, Jane E

    2015-07-01

    In two experiments using a center-out task, we investigated kinesthetic-motor and auditory-motor integrations in 5- to 12-year-old children and young adults. In experiment 1, participants moved a pen on a digitizing tablet from a starting position to one of three targets (visuo-motor condition), and then to one of four targets without visual feedback of the movement. In both conditions, we found that with increasing age, the children moved faster and straighter, and became less variable in their feedforward control. Higher control demands for movements toward the contralateral side were reflected in longer movement times and decreased spatial accuracy across all age groups. When feedforward control relies predominantly on kinesthesia, 7- to 10-year-old children were more variable, indicating difficulties in switching between feedforward and feedback control efficiently during that age. An inverse age progression was found for directional endpoint error; larger errors increasing with age likely reflect stronger functional lateralization for the dominant hand. In experiment 2, the same visuo-motor condition was followed by an auditory-motor condition in which participants had to move to acoustic targets (either white band or one-third octave noise). Since in the latter directional cues come exclusively from transcallosally mediated interaural time differences, we hypothesized that auditory-motor representations would show age effects. The results did not show a clear age effect, suggesting that corpus callosum functionality is sufficient in children to allow them to form accurate auditory-motor maps already at a young age.

  18. Attention and Word Learning in Autistic, Language Delayed and Typically Developing Children

    Directory of Open Access Journals (Sweden)

    Elena eTenenbaum

    2014-05-01

    Full Text Available Previous work has demonstrated that patterns of social attention hold predictive value for language development in typically developing infants. The goal of this research was to explore how patterns of attention in autistic, language delayed, and typically developing children relate to early word learning and language abilities. We tracked patterns of eye movements to faces and objects while children watched videos of a woman teaching them a series of new words. Subsequent test trials measured participants’ recognition of these novel word-object pairings. Results indicated that greater attention to the speaker’s mouth was related to higher scores on standardized measures of language development for autistic and typically developing children (but not for language delayed children. This effect was mediated by age for typically developing, but not autistic children. When effects of age were controlled for, attention to the mouth among language delayed participants was negatively correlated with standardized measures of language learning. Attention to the speaker’s mouth and eyes while she was teaching the new words was also predictive of faster recognition of the newly learned words among autistic children. These results suggest that language delays among children with autism may be driven in part by aberrant social attention, and that the mechanisms underlying these delays may differ from those in language delayed participants without autism.

  19. Development and validation of a parent-report measure for detection of cognitive delay in infancy.

    Science.gov (United States)

    Schafer, Graham; Genesoni, Lucia; Boden, Greg; Doll, Helen; Jones, Rosamond A K; Gray, Ron; Adams, Eleri; Jefferson, Ros

    2014-12-01

    To develop a brief, parent-completed instrument (ERIC - Early Report by Infant Caregivers) for detection of cognitive delay in 10- to 24-month-olds born preterm, or of low birthweight, or with perinatal complications, and to establish ERIC's diagnostic properties. Scores for ERIC were collected from the parents of 317 children meeting ≥inclusion criterion (birthweight Toddler Development-III cognitive scale. Items were retained according to their individual associations with delay. Sensitivity, specificity, and positive and negative predictive values were estimated and a truncated ERIC was developed for use in children cognitive delay in 10- to 24-month-old preterm infants and as a screen for cognitive delay. © 2014 Mac Keith Press.

  20. Piezoelectric motor development at AlliedSignal Inc., Kansas City Division

    Science.gov (United States)

    Pressly, Robert B.; Mentesana, Charles P.

    1994-11-01

    The Kansas City Division of AlliedSignal Inc. has been investigating the fabrication and use of piezoelectric motors in mechanisms for United States Department of Energy (DOE) weapons applications for about four years. These motors exhibit advantages over solenoids and other electromagnetic actuators. Prototype processes have been developed for complete fabrication of motors from stock materials, including abrasive machining of piezoelectric ceramics and more traditional machining of other motor components, electrode plating and sputtering, electric poling, cleaning, bonding and assembly. Drive circuits have been fabricated and motor controls are being developed. Laboratory facilities have been established for electrical/mechanical testing and evaluation of piezo materials and completed motors. Recent project efforts have focused on the potential of piezoelectric devices for commercial and industrial use. A broad range of various motor types and application areas has been identified, primarily in Japan. The Japanese have been developing piezo motors for many years and have more recently begun commercialization. Piezoelectric motor and actuator technology is emerging in the United States and quickly gaining in commercial interest. The Kansas City Division is continuing development of piezoelectric motors and actuators for defense applications while supporting and participating in the commercialization of piezoelectric devices with private industry through various technology transfer and cooperative development initiatives.

  1. Premature Ejaculation, Selective Serotonin Reuptake Inhibitor (ssri) Induced Delayed Ejaculation In The Framework Of The Emotional Motor System

    NARCIS (Netherlands)

    Waldinger, Marcel D; Berendsen, Hemmie H.G.; Blok, Bertil F.M.; Olivier, Berend; Holstege, Gert

    1998-01-01

    Premature ejaculation has generally been considered a psychosexual disorder with psychogenic aetiology. Although still mainly treated by behavioural therapy, in recent years double-blind studies have indicated the beneficial effects of some of the serotonergic anti depressants (SSRIs) in delaying

  2. Do Fine Motor Skills Contribute to Early Reading Development?

    Science.gov (United States)

    Suggate, Sebastian; Pufke, Eva; Stoeger, Heidrun

    2018-01-01

    Background: Little is known about how fine motor skills (FMS) relate to early literacy skills, especially over and above cognitive variables. Moreover, a lack of distinction between FMS, grapho-motor and writing skills may have hampered previous work. Method: In Germany, kindergartners (n = 144, aged 6;1) were recruited before beginning formal…

  3. Development and validation of a fine-motor assessment tool for use with young children in a Chinese population.

    Science.gov (United States)

    Siu, Andrew M H; Lai, Cynthia Y Y; Chiu, Amy S M; Yip, Calvin C K

    2011-01-01

    Most of the fine-motor assessment tools used in Hong Kong have been designed in Western countries, so there is a need to develop a standardized assessment which is relevant to the culture and daily living tasks of the local (that is, Chinese) population. This study aimed to (1) develop a fine-motor assessment tool (the Hong Kong Preschool Fine-Motor Developmental Assessment [HK-PFMDA]) for use with young children in a Chinese population and (2) examine the HK-PFMDA's psychometric properties. The HK-PFMDA was developed by a group of occupational therapists specializing in the area of developmental disabilities in Hong Kong. A panel of 21 experts reviewed the content validity of the instrument. Rasch item analysis was used to examine the model fit of items against the rating scale model, and to explore the dimensionality of the test. Intra- and interrater reliability, convergent validity, and criterion-related validity were examined. The participants included 783 children without disabilities, 45 with autistic spectrum disorder, and 35 with developmental delay. The Rasch analysis suggested that the 87-item HK-PFMDA had a unidimensional structure, as the items explained most (91.6%) of the variance. The HK-PFMDA demonstrated excellent intra- (ICC = .99) and interrater reliability (ICC = .99), and internal consistency (α ranging from .83 to .92). In terms of validity, the HK-PFMDA had significant positive correlations with both age and the convergent measures of the Peabody Developmental Motor Scales (PDMS-2). A set of normative data for local children aged from birth to 6 years was established. The HK-PFMDA has shown excellent psychometric properties and is suitable for clinical application by occupational therapists in the assessment of fine-motor skills development of young children in Chinese populations. Copyright © 2010 Elsevier Ltd. All rights reserved.

  4. Development of delayed hydride cracking resistant-pressure tube

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Young Suk; Kwon, Sang Chul; Kim, S. S.; Yim, K. S

    2000-10-01

    For the first time, we demonstrate that the pattern of nucleation and growth of a DHC crack is governed by the precipitation of hydrides so that the DHC velocity and K{sub IH} are determined by an angle of the cracking plane and the hydride habit plane 10.7. Since texture controls the distribution of the 10.7 habit plane in Zr-2.5Nb pressure tube, we draw a conclusion that a textural change in Zr-2.5Nb tube from a strong tangential texture to the radial texture shall increase the threshold stress intensity factor, K{sub IH}, and decrease the delayed hydride cracking velocity. This conclusion is also verified by a complimentary experiment showing a linear dependence of DHCV and K{sub IH} with an increase in the basal component in the cracking plane. On the basis of the study on the DHC mechanism and the effect of manufacturing processes on the properties of Zr-2.5Nb tube, we have established a manufacturing procedure to make pressure tubes with improved DHC resistance. The main features of the established manufacturing process consist in the two step-cold pilgering process and the intermediate heat treatment in the {alpha} + {beta} phase for Zr-2.5Nb alloy and in the {alpha} phase for Zr-1Nb-1.2Sn-0.4Fe alloy. The manufacturing of DHC resistant-pressure tubes of Zr-2.5Nb and Zr-1N-1.2Sn-0.4Fe was made in the ChMP zirconium plant in Russia under a joint research with Drs. Nikulina and Markelov in VNIINM (Russia). Zr-2.5Nb pressure tube made with the established manufacturing process has met all the specification requirements put by KAERI. Chracterization tests have been jointly conducted by VNIINM and KAERI. As expected, the Zr-2.5Nb tube made with the established procedure has improved DHC resistance compared to that of CANDU Zr-2.5Nb pressure tube used currently. The measured DHC velocity of the Zr-2.5Nb tube meets the target value (DHCV <5x10{sup -8} m/s) and its other properties also were equivalent to those of the CANDU Zr-2.5Nb tube used currently. The Zr-1Nb-1

  5. Determining the Motor Skills Development of Mentally Retarded Children through the Contribution of Visual Arts

    Science.gov (United States)

    Erim, Gonca; Caferoglu, Müge

    2017-01-01

    Visual arts education is a process that helps the reflection of inner worlds, socialization via group works and healthier motor skills development of normally developing or handicapped children like the mentally retarded. This study aims to determine the influence of visual art studies on the motor skills development of primary school first grade…

  6. The motor development of 2 to 6-year old children infected with HIV ...

    African Journals Online (AJOL)

    The aim of the study was to determine the motor development of 2 to 6-year old children (53.74 months, sd 12.49) who were infected (Group 1, n = 17) with HIV and to compare their development with an affected (Group 2, n = 13) and unaffected group (Group 3, n = 12). The motor development of the group was determined ...

  7. Development of the Upgraded DC Brush Gear Motor for Spacebus Platforms

    Science.gov (United States)

    Berning, Robert H.; Viout, Olivier

    2010-01-01

    The obsolescence of materials and processes used in the manufacture of traditional DC brush gear motors has necessitated the development of an upgraded DC brush gear motor (UBGM). The current traditional DC brush gear motor (BGM) design was evaluated using Six-Sigma process to identify potential design and production process improvements. The development effort resulted in a qualified UBGM design which improved manufacturability and reduced production costs. Using Six-Sigma processes and incorporating lessons learned during the development process also improved motor performance for UBGM making it a more viable option for future use as a deployment mechanism in space flight applications.

  8. DISTURBANCE OF NORMAL MOTOR DEVELOPMENT IN THE FIRST YEAR OF LIFE

    Directory of Open Access Journals (Sweden)

    Lidija Dimitrijević

    2005-07-01

    Full Text Available The adoption of the basic motor skills in the first year of life (postural head control, lateral transfers into a lying position, sitting, standing, walking, crawling, grasping... goes on quite spontaneously. A child learns all the motor actions by itself and that is why it is not necessary to “teach” a child to seat, grasp, stand, walk... Teaching a child the basic motor skills stands for a rough, unnecessary and undesirable involvement into spontaneous motor development, and, due to this, the normal adoption of motor skills is slowed down. For the normal motor development, children do not need helping devices (baby buggy, baby jump.... Helping devices suppress in children their natural urge to walk, complicate its development and may have harmful effects like equinus feet, deformed feet and spine and so on.

  9. Speech development delay in a child with foetal alcohol syndrome

    Directory of Open Access Journals (Sweden)

    Jacek Wilczyński

    2016-09-01

    Full Text Available A female foetus in her mother’s womb was exposed to high concentrations of alcohol at each stage of pregnancy on a long-term basis, which resulted in a permanent disability. In addition to a number of deficiencies in the overall functioning of the body of the child, there are serious problems pertaining to verbal communication. This thesis aims to describe foetal alcohol syndrome (FAS disease and present the basic problems with communication functions in a child, caused by damage of brain structures responsible for speech development. The thesis includes a speech diagnosis and therapy program adapted to the presented case. In the Discussion Section we have presented characteristics of communication disorders in case of children with FAS and the description of developmental malformations, neurobehavioral disorders, and environmental factors affecting the development of the child’s speech.

  10. Kisspeptin regulates ovarian steroidogenesis during delayed embryonic development in the fruit bat, Cynopterus sphinx.

    Science.gov (United States)

    Anuradha; Krishna, Amitabh

    2017-11-01

    Cynopterus sphinx, a fruit bat, undergoes delayed embryonic development during the winter months, a period that corresponds to low levels of progesterone and estradiol synthesis by the ovary. Kisspeptins (KPs) are a group of neuropeptide hormones that act via G-protein coupled receptor 54 (GPR54) to stimulate hypothalamic secretion of Gonadotropin-releasing hormone, thereby regulating ovarian steroidogenesis, folliculogenesis, and ovulation. GPR54 is also expressed in the ovary, suggesting a direct role for KPs in ovarian steroidogenesis. The aim of present study was to determine if a low serum level of KP is responsible for reduced progesterone and estradiol levels during the period of delayed embryonic development in C. sphinx. Indeed, low serum KP abundance corresponded to reduced expression of GPR54 in ovarian luteal cells during the period of delayed development compared to normal development. In vitro and in vivo treatment with KP increased GPR54 abundance, via Extracellular signal regulated kinase and its downstream mediators, leading to increased progesterone synthesis in the ovary during delayed embryonic development. KP treatment also increased cholesterol uptake and elevated expression of Luteinizing hormone receptor and Steroid acute regulatory protein in the ovary, suggesting that elevation in circulating KP during delayed embryonic development may reactivate luteal activity. KPs may also enhance cell survival (BCL-2, reduced Caspase 3 activity) and angiogenesis (Vascular endothelium growth factor) during this period. The findings of this study thus demonstrate a regulatory role for KPs in the maintenance of luteal steroidogenesis during pregnancy in C. sphinx. © 2017 Wiley Periodicals, Inc.

  11. The role of the Occupational Therapist with children with neuropsychomotor development delay

    Directory of Open Access Journals (Sweden)

    Ariana Carramaschi de Souza

    2013-04-01

    Full Text Available Prematurity it is the birth of infants before 37 weeks gestation; it is known that such a condition associated with prolonged hospitalization is a risk factor to the development of infants. This study aimed to highlight the gains related to sensorial, neuromuscleskeletal and motor performance components occurred after occupational therapy intervention in a preterm infant. To this end, a literature survey as carried out, as well as weekly assistance of occupational therapy at the Lucy Montoro rehabilitation center in Ribeirao Preto, state of Sao Paulo, where the Alberta Infant Motor Scale (AIMS was used in an extremely preterm infant in order to evaluate and quantify motor performance. After assessment, we used playful resources to improve sensorial neuromuscleskeletal motor performance components so that, later, they assist in greater independence for effective participation in the playing. We verified that the intervention brought about the development of a repertoire of sensorial neuromuscleskeletal motor actions; through this process, when correction of the chronological age was made by the prematurity factor, it was possible to observe that the gains were very satisfactory and consistent with what is expected for the corrected age, demonstrating the effectiveness of occupational therapy assistance as an agent for minimizing the effects caused by risk factors to neuropsychomotor development.

  12. Delayed development of radiation sickness in animals following partial exposure

    International Nuclear Information System (INIS)

    Vershinina, S.F.; Markochev, A.V.

    1995-01-01

    Causes of reduction of the life span of animals after partial exposure of the head, thorax, and abdomen are analyzed. Pulmonosclerosis and cardiosclerosis were mainly responsible for animal death following partial radiation exposure of the thorax; these conditions appreciably shortened the life span of the animals. After exposure of the head deaths were due to pneumonias which negligibly reduced the duration of life. Exposure of the abdomen led to the development of diabetes mellitus which shortened the life span by half. 18 refs., 1 tab

  13. Motor control of handwriting in the developing brain: A review.

    Science.gov (United States)

    Palmis, Sarah; Danna, Jeremy; Velay, Jean-Luc; Longcamp, Marieke

    This review focuses on the acquisition of writing motor aspects in adults, and in 5-to 12-year-old children without learning disabilities. We first describe the behavioural aspects of adult writing and dominant models based on the notion of motor programs. We show that handwriting acquisition is characterized by the transition from reactive movements programmed stroke-by-stroke in younger children, to an automatic control of the whole trajectory when the motor programs are memorized at about 10 years old. Then, we describe the neural correlates of adult writing, and the changes that could occur with learning during childhood. The acquisition of a new skill is characterized by the involvement of a network more restricted in space and where neural specificity is increased in key regions. The cerebellum and the left dorsal premotor cortex are of fundamental importance in motor learning, and could be at the core of the acquisition of handwriting.

  14. Isl1 is required for multiple aspects of motor neuron development.

    Science.gov (United States)

    Liang, Xingqun; Song, Mi-Ryoung; Xu, ZengGuang; Lanuza, Guillermo M; Liu, Yali; Zhuang, Tao; Chen, Yihan; Pfaff, Samuel L; Evans, Sylvia M; Sun, Yunfu

    2011-07-01

    The LIM homeodomain transcription factor Islet1 (Isl1) is expressed in multiple organs and plays essential roles during embryogenesis. Isl1 is required for the survival and specification of spinal cord motor neurons. Due to early embryonic lethality and loss of motor neurons, the role of Isl1 in other aspects of motor neuron development remains unclear. In this study, we generated Isl1 mutant mouse lines expressing graded doses of Isl1. Our study has revealed essential roles of Isl1 in multiple aspects of motor neuron development, including motor neuron cell body localization, motor column formation and axon growth. In addition, Isl1 is required for survival of cranial ganglia neurons. Copyright © 2011 Elsevier Inc. All rights reserved.

  15. The role of parenting in the physical and motor development in young children

    NARCIS (Netherlands)

    van der Ploeg, N.; Oosterman, M.; Savelsbergh, G.J.P.; Schuengel, Carlo; Ledebt, A.; de Moor, M.H.M.

    2016-01-01

    The development of motor skills is important for children’s overall functioning. While children born preterm and/or with a low-birth-weight are known to be at risk for impaired motor development, little research has been conducted on how parents can support and stimulate children’s physical and

  16. A New Inventory for Assessing "Affordances in the Home Environment for Motor Development ("AHEMD-SR")

    Science.gov (United States)

    Gabbard, Carl; Cacola, Priscila; Rodrigues, Luis Paulo

    2008-01-01

    A contemporary view of motor development considers environmental influences as critical factors in optimal growth and behavior, with the home being the primary agent. The intent of this communication is to introduce the "Affordances in the Home Environment for Motor Development Self-Report" ("AHEMD-SR") to early childhood practitioners. The…

  17. The Effects of Modified Games on the Development of Gross Motor Skill in Preschoolers

    Science.gov (United States)

    Lestari, Indah; Ratnaningsih, Tri

    2016-01-01

    Gross motor skills on children must be optimized much earlier since it plays important role not only on their interaction process but also in supporting other multiple developments. One of the means in developing child's motor skill is by providing innovative games i.e. modified games including game format, game timing, and game sequence. The…

  18. Motor Skill Performance by Low SES Preschool and Typically Developing Children on the PDMS-2

    Science.gov (United States)

    Liu, Ting; Hoffmann, Chelsea; Hamilton, Michelle

    2017-01-01

    The purpose of this study was to compare the motor skill performance of preschool children from low socioeconomic (SES) backgrounds to their age matched typically developing peers using the Peabody Developmental Motor Scales-2 (PDMS-2). Sixty-eight children (34 low SES and 34 typically developing; ages 3-5) performed the PDMS-2. Standard scores…

  19. Corpus callosum tissue loss and development of motor and global cognitive impairment

    DEFF Research Database (Denmark)

    Frederiksen, Kristian S; Garde, Ellen; Skimminge, Arnold

    2011-01-01

    To examine the impact of corpus callosum (CC) tissue loss on the development of global cognitive and motor impairment in the elderly.......To examine the impact of corpus callosum (CC) tissue loss on the development of global cognitive and motor impairment in the elderly....

  20. Possible linkage between visual and motor development in children with cerebral palsy.

    Science.gov (United States)

    Lew, Helen; Lee, Hee Song; Lee, Jae Yeun; Song, Junyoung; Min, Kyunghoon; Kim, MinYoung

    2015-03-01

    The purpose of this study was to examine ophthalmic disorders associated with neurological disorders in children with cerebral palsy. Children clinically diagnosed as cerebral palsy with supportive abnormal magnetic resonance imaging results were included in this prospective study. All participants were recommended to have comprehensive ophthalmic exams. To assess motor function, the Gross Motor Function Classification System and the Gross Motor Function Measure were used. To assess motor and cognitive function, the Bayley Scales of Infant Development-II was used. Forty-seven children completed all the evaluations and the data were analyzed. Ametropia was seen in 78.7% and strabismus was seen in 44.7% of the 47 children. When subjects were divided into severely impaired and mildly impaired groups based on Gross Motor Function Classification System level, ametropia was more prevalent in the severely impaired than the mildly impaired (95.8% versus 60.9%, P gross motor impairment correlated with the degree of refractive error in the subjects older than 36 months (r = -0.65 for the Bayley Scales of Infant Development-II motor scale, P gross motor function have a high possibility of severe refractive disorder that becomes evident from 36 months after birth. These results suggest that brain injury and impaired motor development negatively affect ophthalmic development. Hence, an ophthalmic examination is recommended for young children with cerebral palsy to start early management. Copyright © 2015 Elsevier Inc. All rights reserved.

  1. Fine motor skill proficiency in typically developing children: On or off the maturation track?

    Science.gov (United States)

    Gaul, David; Issartel, Johann

    2016-04-01

    Fine motor skill proficiency is an essential component of numerous daily living activities such as dressing, feeding or playing. Poor fine motor skills can lead to difficulties in academic achievement, increased anxiety and poor self-esteem. Recent findings have shown that children's gross motor skill proficiency tends to fall below established developmental norms. A question remains: do fine motor skill proficiency levels also fall below developmental norms? The aim of this study was to examine the current level of fine motor skill in Irish children. Children (N=253) from 2nd, 4th and 6th grades (mean age=7.12, 9.11 and 11.02 respectively) completed the Fine Motor Composite of the Bruininks Oseretsky Test of Motor Proficiency 2nd Edition (BOT-2). Analysis revealed that only 2nd grade children met the expected level of fine motor skill proficiency. It was also found that despite children's raw scores improving with age, children's fine motor skill proficiency was not progressing at the expected rate given by normative data. This leads us to question the role and impact of modern society on fine motor skills development over the past number of decades. Copyright © 2015 Elsevier B.V. All rights reserved.

  2. Cross-cultural validity of standardized motor development screening and assessment tools: a systematic review.

    Science.gov (United States)

    Mendonça, Bianca; Sargent, Barbara; Fetters, Linda

    2016-12-01

    To investigate whether standardized motor development screening and assessment tools that are used to evaluate motor abilities of children aged 0 to 2 years are valid in cultures other than those in which the normative sample was established. This was a systematic review in which six databases were searched. Studies were selected based on inclusion/exclusion criteria and appraised for evidence level and quality. Study variables were extracted. Twenty-three studies representing six motor development screening and assessment tools in 16 cultural contexts met the inclusion criteria: Alberta Infant Motor Scale (n=7), Ages and Stages Questionnaire, 3rd edition (n=2), Bayley Scales of Infant and Toddler Development, 3rd edition (n=8), Denver Developmental Screening Test, 2nd edition (n=4), Harris Infant Neuromotor Test (n=1), and Peabody Developmental Motor Scales, 2nd edition (n=1). Thirteen studies found significant differences between the cultural context and normative sample. Two studies established reliability and/or validity of standardized motor development assessments in high-risk infants from different cultural contexts. Five studies established new population norms. Eight studies described the cross-cultural adaptation of a standardized motor development assessment. Standardized motor development assessments have limited validity in cultures other than that in which the normative sample was established. Their use can result in under- or over-referral for services. © 2016 Mac Keith Press.

  3. Influence of Affordances in the Home Environment on Motor Development of Young Children in Japan

    Directory of Open Access Journals (Sweden)

    Shiro Mori

    2013-01-01

    Full Text Available Previous research indicates that the home environment is a significant factor in early child development. The present study examined influence of the multidimensional home environment on young Japanese children’s motor development. A Japanese translation of the Affordances in the Home Environment for Motor Development-Self Report (AHEMD-SR was used to assess home motor affordances in 262 families. Motor ability was assessed by parental report using the Enjoji Infant Analytic Developmental Test. We also asked parents to rate their own physical activity in terms of level and years of experience. As results, we found that the home environment in Japan was generally sufficient for children’s motor development and that children’s access to Fine Motor Toys (FMT and Gross Motor Toys (GMT had the strongest influence on their development. Analysis also indicated that AHEMD-SR scores were higher for children of parents who had some level of physical activity experience compared to children whose parents indicated no physical activity experience. Parents’ self-reported activity level was correlated with higher scores for the subscales FMT and GMT and for total AHEMD-SR score. These results indicate that both the physical and social-psychological environments (parental experience and views of the home influenced children’s motor development.

  4. Early lexical development and risk of verbal and nonverbal cognitive delay at school age

    NARCIS (Netherlands)

    Ghassabian, A.; Rescorla, L.; Henrichs, J.; Jaddoe, V.W.; Verhulst, F.C.; Tiemeier, H.W.

    2014-01-01

    Aim To characterise the relationship between preschool lexical delay and language comprehension and nonverbal intelligence at school age. Methods The mothers of 2724 children completed the MacArthur Communicative Development Inventory when their child reached 1.5 years and the Language Development

  5. Development of Pointing Gestures in Children with Typical and Delayed Language Acquisition

    Science.gov (United States)

    Lüke, Carina; Ritterfeld, Ute; Grimminger, Angela; Liszkowski, Ulf; Rohlfing, Katharina J.

    2017-01-01

    Purpose: This longitudinal study compared the development of hand and index-finger pointing in children with typical language development (TD) and children with language delay (LD). First, we examined whether the number and the form of pointing gestures during the second year of life are potential indicators of later LD. Second, we analyzed the…

  6. Effects of Motor Skill Intervention on Gross Motor Development, Creative Thinking and Academic Performance in Preschool Children

    Directory of Open Access Journals (Sweden)

    Judith Jiménez Díaz

    2010-08-01

    Full Text Available The purpose of this study was to investigate how students (mean= 6.08±0.5 years benefit from a physical education program in motor performance, creative thinking and academic achievement. Students (n = 39 were randomly assigned to comparison group (6 boys and 7 girls who received the regular preschool program (which includes 1 session of 30 minutes per week; intervention group 1 (6 boys and 7 girls who received the regular preschool program plus 1 session of 30 minutes per week of the intervention program; or intervention group 2 (6 boys and 7 girls, who received the regular preschool program plus 1 session of 60 minutes per week of the intervention program; during 8 weeks. All participants performed the Test of Gross Motor Development (TGMD-2 and the Torrance Test of Creative Thinking (TTCT before and after the study. The academic achievement score was given by the school. The ANOVA (Group x Gender x Time pre and post analysis revealed a significant triple interaction in the object control. Significant double interactions in the locomotor subscale and in the gross motor quotient were also found. After the post-hoc analysis, the results suggest that the physical education program benefits the gross motor performance and did not have an effect on the creative thinking or on the academic achievement.

  7. Peripheral Nerve Injury in Developing Rats Reorganizes Representation Pattern in Motor Cortex

    Science.gov (United States)

    Donoghue, John P.; Sanes, Jerome N.

    1987-02-01

    We investigated the effect of neonatal nerve lesions on cerebral motor cortex organization by comparing the cortical motor representation of normal adult rats with adult rats that had one forelimb removed on the day of birth. Mapping of cerebral neocortex with electrical stimulation revealed an altered relationship between the motor cortex and the remaining muscles. Whereas distal forelimb movements are normally elicited at the lowest threshold in the motor cortex forelimb area, the same stimuli activated shoulder and trunk muscles in experimental animals. In addition, an expanded cortical representation of intact body parts was present and there was an absence of a distinct portion of motor cortex. These data demonstrate that representation patterns in motor cortex can be altered by peripheral nerve injury during development.

  8. A Study on the Development of BLDC Motor with High Power Density

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Hyun Cheol; Kong, Yeong Kyung; Choi, Tae In [Agency for Defense Development (Korea); Song, Jong Hwan [Hyosung Ltd., (Korea)

    2000-05-01

    The motor for torpedo propulsion is needed the compact and short rating high power characteristics. This paper describes the development of the motor through the theory and Finite Element Method(FEM) analysis for Brushless Direct Current Motor(BLDCM) of 7 phase 6 poles. Back EMF, inductance and eddy current loss were analyzed. The proposed methods like magnetic wedge acquired by these FEM analysis were introduced. Phase-leading angle using encoder was used. Test results on the motor of 7 phases 6 poles were showed the validity of proposed methods and phase-leading angle. (author). 9 refs., 12 figs., 5 tabs.

  9. Development of Ultra-Efficient Electric Motors Final Technical Report Covering work from April 2002 through September 2007

    International Nuclear Information System (INIS)

    Rich Schiferl

    2008-01-01

    High temperature superconducting (HTS) motors offer the potential for dramatic volume and loss reduction compared to conventional, high horsepower, industrial motors. This report is the final report on the results of eight research tasks that address some of the issues related to HTS motor development that affect motor efficiency, cost, and reliability

  10. Role of adiponectin in delayed embryonic development of the short-nosed fruit bat, Cynopterus sphinx.

    Science.gov (United States)

    Anuradha; Krishna, Amitabh

    2014-12-01

    The aim of this study was to evaluate the role of adiponectin in the delayed embryonic development of Cynopterus sphinx. Adiponectin receptor (ADIPOR1) abundance was first observed to be lower during the delayed versus non-delayed periods of utero-embryonic unit development. The effects of adiponectin treatment on embryonic development were then evaluated during the period of delayed development. Exogenous treatment increased the in vivo rate of embryonic development, as indicated by an increase in weight, ADIPOR1 levels in the utero-embryonic unit, and histological changes in embryonic development. Treatment with adiponectin during embryonic diapause showed a significant increase in circulating progesterone and estradiol concentrations, and in production of their receptors in the utero-embryonic unit. The adiponectin-induced increase in estradiol synthesis was correlated with increased cell survival (BCL2 protein levels) and cell proliferation (PCNA protein levels) in the utero-embryonic unit, suggesting an indirect effect of adiponectin via estradiol synthesis by the ovary. An in vitro study further confirmed the in vivo findings that adiponectin treatment increases PCNA levels together with increased uptake of glucose by increasing the abundance of glucose transporter 8 (GLUT8) in the utero-embryonic unit. The in vitro study also revealed that adiponectin, together with estradiol but not alone, significantly increased ADIPOR1 protein levels. Thus, adiponectin works in concert with estradiol to increase glucose transport to the utero-embryonic unit and promote cell proliferation, which together accelerate embryonic development. © 2014 Wiley Periodicals, Inc.

  11. Individual development of preschool children-prevalences and determinants of delays in Germany: a cross-sectional study in Southern Bavaria

    Directory of Open Access Journals (Sweden)

    Stich Heribert L

    2012-12-01

    Full Text Available Abstract Background Even minor abnormalities of early child development may have dramatic long term consequences. Accurate prevalence rates for a range of developmental impairments have been difficult to establish. Since related studies have used different methodological approaches, direct comparisons of the prevalence of developmental delays are difficult. The understanding of the key factors affecting child development, especially in preschool aged children remains limited. We used data from school entry examinations in Bavaria to measure the prevalence of developmental impairments in pre-school children beginning primary school in 1997–2009. Methods The developmental impairments of all school beginners in the district of Dingolfing- Landau, Bavaria were assessed using modified “Bavarian School Entry Model” examination from 1997 to 2009 (N=13,182. The children were assessed for motor, cognitive, language and psychosocial impairments using a standardised medical protocol. Prevalence rates of impairments in twelve domains of development were estimated. Using uni- and multivariable logistic regression models, association between selected factors and development delays were assessed. Results The highest prevalence existed for impairments of pronunciation (13.8% followed by fine motor impairments (12.2%, and impairments of memory and concentration (11.3% and the lowest for impairments of rhythm of speech (3.1%. Younger children displayed more developmental delays. Male gender was strongly associated with all developmental impairments (highest risk for fine motor impairments = OR 3.22, 95% confidence interval 2.86-3.63. Preschool children with siblings (vs. children without any siblings were at higher risk of having impairments in pronunciation (OR 1.31, 1.14-1.50. The influence of the non-German nationality was strong, with a maximum risk increase for the subareas of grammar and psychosocial development. Although children with non

  12. Individual development of preschool children-prevalences and determinants of delays in Germany: a cross-sectional study in Southern Bavaria.

    Science.gov (United States)

    Stich, Heribert L; Baune, Bernhard Th; Caniato, Riccardo N; Mikolajczyk, Rafael T; Krämer, Alexander

    2012-12-05

    Even minor abnormalities of early child development may have dramatic long term consequences. Accurate prevalence rates for a range of developmental impairments have been difficult to establish. Since related studies have used different methodological approaches, direct comparisons of the prevalence of developmental delays are difficult. The understanding of the key factors affecting child development, especially in preschool aged children remains limited. We used data from school entry examinations in Bavaria to measure the prevalence of developmental impairments in pre-school children beginning primary school in 1997-2009. The developmental impairments of all school beginners in the district of Dingolfing-Landau, Bavaria were assessed using modified "Bavarian School Entry Model" examination from 1997 to 2009 (N=13,182). The children were assessed for motor, cognitive, language and psychosocial impairments using a standardised medical protocol. Prevalence rates of impairments in twelve domains of development were estimated. Using uni- and multivariable logistic regression models, association between selected factors and development delays were assessed. The highest prevalence existed for impairments of pronunciation (13.8%) followed by fine motor impairments (12.2%), and impairments of memory and concentration (11.3%) and the lowest for impairments of rhythm of speech (3.1%). Younger children displayed more developmental delays. Male gender was strongly associated with all developmental impairments (highest risk for fine motor impairments = OR 3.22, 95% confidence interval 2.86-3.63). Preschool children with siblings (vs. children without any siblings) were at higher risk of having impairments in pronunciation (OR 1.31, 1.14-1.50). The influence of the non-German nationality was strong, with a maximum risk increase for the subareas of grammar and psychosocial development. Although children with non-German nationality had a reduced risk of disorders for the rhythm

  13. Melatonin regulates delayed embryonic development in the short-nosed fruit bat, Cynopterus sphinx.

    Science.gov (United States)

    Banerjee, Arnab; Meenakumari, K J; Udin, S; Krishna, A

    2009-12-01

    The aim of the present study was to evaluate the seasonal variation in serum melatonin levels and their relationship to the changes in the serum progesterone level, ovarian steroidogenesis, and embryonic development during two successive pregnancies of Cynopterus sphinx. Circulating melatonin concentrations showed two peaks; one coincided with the period of low progesterone synthesis and delayed embryonic development, whereas the second peak coincided with regressing corpus luteum. This finding suggests that increased serum melatonin level during November-December may be responsible for delayed embryonic development by suppressing progesterone synthesis. The study showed increased melatonin receptors (MTNR1A and MTNR1B) in the corpus luteum and in the utero-embryonic unit during the period of delayed embryonic development. The in vitro study showed that a high dose of melatonin suppressed progesterone synthesis, whereas a lower dose of melatonin increased progesterone synthesis by the ovary. The effects of melatonin on ovarian steroidogenesis are mediated through changes in the expression of peripheral-type benzodiazepine receptor, P450 side chain cleavage enzyme, and LH receptor proteins. This study further showed a suppressive impact of melatonin on the progesterone receptor (PGR) in the utero-embryonic unit; this effect might contribute to delayed embryonic development in C. sphinx. The results of the present study thus suggest that a high circulating melatonin level has a dual contribution in retarding embryonic development in C. sphinx by impairing progesterone synthesis as well as by inhibiting progesterone action by reducing expression of PGR in the utero-embryonic unit.

  14. Development of a subway operation incident delay model using accelerated failure time approaches.

    Science.gov (United States)

    Weng, Jinxian; Zheng, Yang; Yan, Xuedong; Meng, Qiang

    2014-12-01

    This study aims to develop a subway operational incident delay model using the parametric accelerated time failure (AFT) approach. Six parametric AFT models including the log-logistic, lognormal and Weibull models, with fixed and random parameters are built based on the Hong Kong subway operation incident data from 2005 to 2012, respectively. In addition, the Weibull model with gamma heterogeneity is also considered to compare the model performance. The goodness-of-fit test results show that the log-logistic AFT model with random parameters is most suitable for estimating the subway incident delay. First, the results show that a longer subway operation incident delay is highly correlated with the following factors: power cable failure, signal cable failure, turnout communication disruption and crashes involving a casualty. Vehicle failure makes the least impact on the increment of subway operation incident delay. According to these results, several possible measures, such as the use of short-distance and wireless communication technology (e.g., Wifi and Zigbee) are suggested to shorten the delay caused by subway operation incidents. Finally, the temporal transferability test results show that the developed log-logistic AFT model with random parameters is stable over time. Copyright © 2014 Elsevier Ltd. All rights reserved.

  15. Deliberate Laterality Practice Facilitates Sensory-Motor Processing in Developing Children

    Science.gov (United States)

    Pedersen, Scott J.

    2014-01-01

    Background: The innate ability for typically developing children to attain developmental motor milestones early in life has been a thoroughly researched area of inquiry. Nonetheless, as children grow and are required to perform more complex motor skills in order to experience success in physical activity and sport pursuits, the range of…

  16. Development of the Correspondence between Real and Imagined Fine and Gross Motor Actions

    Science.gov (United States)

    Sachet, Alison B.; Frey, Scott H.; Jacobs, Stéphane; Taylor, Marjorie

    2016-01-01

    The development of the correspondence between real and imagined motor actions was investigated in 2 experiments. Experiment 1 evaluated whether children imagine body position judgments of fine motor actions in the same way as they perform them. Thirty-two 8-year-old children completed a task in which an object was presented in different…

  17. Research on the Boost of Development on Young Children's Fine Motor by Folk Games

    Science.gov (United States)

    Wei, Xia

    2016-01-01

    As Chinese traditional folk culture, folk games have unique educational value which can boost the development of young children's fine motor. Based on previous investigation of fine motor skill of children in Nanchong, Sichuan Province, the researcher chose a middle class in public city kindergarten A with lower survey score as the study object.…

  18. Development of a dc motor with virtually zero powered magnetic bearing

    Science.gov (United States)

    1971-01-01

    The development of magnetic bearings for use in direct current electric motors is discussed. The characteristics of the magnets used in the construction of the bearings are described. A magnetic bearing using steel armoring on permanent magnets was selected for performance tests. The specifications of the motor are presented. The test equipment used in the evaluation is described.

  19. Development and face validity of a cerebral visual impairment motor questionnaire for children with cerebral palsy

    NARCIS (Netherlands)

    Salavati, Masoud; Waninge, Aly; Rameckers, E.A.A.; van der Steen, J; Krijnen, W.P.; van der Schans, C.P.; Steenbergen, B.

    2016-01-01

    AIM: The objectives of this study were (i) to develop two cerebral visual impairment motor questionnaires (CVI-MQ's) for children with cerebral palsy (CP): one for children with Gross Motor Function Classification System (GMFCS) levels I, II and III and one for children with GMFCS levels IV and V;

  20. The Effects of Basketball Basic Skills Training on Gross Motor Skills Development of Female Children

    Science.gov (United States)

    Bayazit, Betul

    2015-01-01

    The purpose of this study was to investigate the effects of basketball basic skills training on gross motor skills development of female children in Turkey. For that purpose, 40 female children took part in the study voluntarily. Basketball basic skills test was used to improve the gross motor skills of the female children in the study. Also,…

  1. Development and face validity of a cerebral visual impairment motor questionnaire for children with cerebral palsy

    NARCIS (Netherlands)

    Salavati, M.; Waninge, A.; Rameckers, E. A. A.; van der Steen, J.; Krijnen, W. P.; van der Schans, C. P.; Steenbergen, B.

    Aim The objectives of this study were (i) to develop two cerebral visual impairment motor questionnaires (CVI-MQ's) for children with cerebral palsy (CP): one for children with Gross Motor Function Classification System (GMFCS) levels I, II and III and one for children with GMFCS levels IV and V;

  2. development of a motorized kneader for groundnut oil extraction

    African Journals Online (AJOL)

    Dr Obe

    The machine was constructed, and evaluated for its performance in terms of, its kneading time and ... groundnut oil extraction is a profitable business, and mosly done by women. It was also .... (2.0 hp) single-phase electric motor and its small.

  3. A Senior Project-Based Multiphase Motor Drive System Development

    Science.gov (United States)

    Abdel-Khalik, Ayman S.; Massoud, Ahmed M.; Ahmed, Shehab

    2016-01-01

    Adjustable-speed drives based on multiphase motors are of significant interest for safety-critical applications that necessitate wide fault-tolerant capabilities and high system reliability. Although multiphase machines are based on the same conceptual theory as three-phase machines, most undergraduate electrical machines and electric drives…

  4. MotorSense: Using Motion Tracking Technology to Support the Identification and Treatment of Gross-Motor Dysfunction.

    Science.gov (United States)

    Arnedillo-Sánchez, Inmaculada; Boyle, Bryan; Bossavit, Benoît

    2017-01-01

    MotorSense is a motion detection and tracking technology that can be implemented across a range of environments to assist in detecting delays in gross-motor skills development. The system utilises the motion tracking functionality of Microsoft's Kinect™. It features games that require children to perform graded gross-motor tasks matched with their chronological and developmental ages. This paper describes the rationale for MotorSense, provides an overview of the functionality of the system and illustrates sample activities.

  5. Motor development in 9-month-old infants in relation to cultural differences and iron status.

    Science.gov (United States)

    Angulo-Barroso, Rosa M; Schapiro, Lauren; Liang, Weilang; Rodrigues, Onike; Shafir, Tal; Kaciroti, Niko; Jacobson, Sandra W; Lozoff, Betsy

    2011-03-01

    Motor development, which allows infants to explore their environment, promoting cognitive, social, and perceptual development, can be influenced by cultural practices and nutritional factors, such as iron deficiency. This study compared fine and gross motor development in 209 9-month-old infants from urban areas of China, Ghana, and USA (African-Americans) and considered effects of iron status. Iron deficiency anemia was most common in the Ghana sample (55%) followed by USA and China samples. Controlling for iron status, Ghanaian infants displayed precocity in gross motor development and most fine-motor reach-and-grasp tasks. US African-Americans performed the poorest in all tasks except bimanual coordination and the large ball. Controlling for cultural site, iron status showed linear trends for gross motor milestones and fine motor skills with small objects. Our findings add to the sparse literature on infant fine motor development across cultures. The results also indicate the need to consider nutritional factors when examining cultural differences in infant development. Copyright © 2010 Wiley Periodicals, Inc.

  6. Clubfoot Does Not Impair Gross Motor Development in 5-Year-Olds.

    Science.gov (United States)

    Zapata, Karina A; Karol, Lori A; Jeans, Kelly A; Jo, Chan-Hee

    2018-04-01

    To evaluate the gross motor development of 5-year-olds using the Peabody Developmental Motor Scales, 2nd Edition (PDMS-2), test after initial nonoperative management of clubfoot as infants. The PDMS-2 Stationary, Locomotion, and Object Manipulation subtests were assessed on 128 children with idiopathic clubfeet at the age of 5 years. Children were categorized by their initial clubfoot severity as greater than 13, unilateral or bilateral involvement, and required surgery. Children with treated clubfeet had average gross motor scores (99 Gross Motor Quotient) compared with age-matched normative scores. Children with more severe clubfeet required surgery significantly more than children with less severe scores (P < .01). Peabody scores were not significantly different according to initial clubfoot severity, unilateral versus bilateral involvement, and surgical versus nonsurgical outcomes. Clubfoot does not significantly impair gross motor development in 5-year-olds.

  7. Delayed speech development, facial asymmetry, strabismus, and transverse ear lobe creases: a new syndrome?

    OpenAIRE

    Méhes, K

    1993-01-01

    A 4 year 9 month old boy and his 3 year 5 month old sister presented with delayed speech development, facial asymmetry, strabismus, and transverse ear lobe creases. The same features were found in their mother, but the father had no such anomalies. To our knowledge this familial association has not been described before and may represent an autosomal dominant syndrome.

  8. IPRODIONE DELAYS MALE RAT PUBERTAL DEVELOPMENT, REDUCING SERUM TESTOSTERONE AND EX VIVO TESTOSTERONE PRODUCTION

    Science.gov (United States)

    Iprodione (IPRO) is a dichlorophenyl dicarboximide fungicide similar to the androgen receptor (AR) antagonist vinclozolin. The current studies were designed to determine if IPRO would delay male rat pubertal development like vinclozolin and to identify the mechanism(s) of action...

  9. Granger causality mapping during joint actions reveals evidence for forward models that could overcome sensory-motor delays.

    Directory of Open Access Journals (Sweden)

    Idil Kokal

    Full Text Available Studies investigating joint actions have suggested a central role for the putative mirror neuron system (pMNS because of the close link between perception and action provided by these brain regions [1], [2], [3]. In contrast, our previous functional magnetic resonance imaging (fMRI experiment demonstrated that the BOLD response of the pMNS does not suggest that it directly integrates observed and executed actions during joint actions [4]. To test whether the pMNS might contribute indirectly to the integration process by sending information to brain areas responsible for this integration (integration network, here we used Granger causality mapping (GCM [5]. We explored the directional information flow between the anterior sites of the pMNS and previously identified integrative brain regions. We found that the left BA44 sent more information than it received to both the integration network (left thalamus, right middle occipital gyrus and cerebellum and more posterior nodes of the pMNS (BA2. Thus, during joint actions, two anatomically separate networks therefore seem effectively connected and the information flow is predominantly from anterior to posterior areas of the brain. These findings suggest that the pMNS is involved indirectly in joint actions by transforming observed and executed actions into a common code and is part of a generative model that could predict the future somatosensory and visual consequences of observed and executed actions in order to overcome otherwise inevitable neural delays.

  10. Relationship between delayed embryonic development and metabolic factors and fat deposition in fruit bat Cynopterus sphinx.

    Science.gov (United States)

    Banerjee, Arnab; Meenakumari, K J; Krishna, Amitabh

    2007-01-01

    The present study was undertaken in the fruit bat Cynopterus sphinx, which breeds twice in quick succession at Varanasi, India. Its gestation period varies significantly in the two successive pregnancies of the year owing to delayed embryonic development during the first (winter) pregnancy. The primary aim of the present study was to determine the role of metabolic factors in delayed embryonic development in the fruit bat C. sphinx. Variation in bodyweight, fat deposition, oxygen (O(2)) consumption rate, basal metabolic rate (BMR), body temperature (Tb) and hepatic succinate dehydrogenase (SDH) activity, along with circulating levels of thyroid hormones (tri-iodothyronine and thyroxine), were examined as metabolic factors during the two successive pregnancies in C. sphinx. The increase in bodyweight observed in November was due to accumulation of white adipose tissue in the posterior abdominal region. A significant decline in O(2) consumption rate, BMR, Tb and SDH activity was found in early winter in November-December, which coincides closely with the period of fat accumulation and with the period of delayed embryonic development in C. sphinx. A significantly higher O(2) consumption rate, BMR, Tb and SDH activity was noted during the second pregnancy in, when embryonic development was relatively faster. Thyroid hormone levels were high during the period of embryonic delay compared with levels during the remaining months. The results of the present study suggest that the delayed embryonic development in C. sphinx during early winter may be due to a low O(2) consumption rate, BMR, Tb and SDH activity in November-December. The energy saved by suppressing embryonic development in this species may be advantageous for fat accumulation. Increased thyroid hormone levels during the early winter period might facilitate fat accumulation in C. sphinx.

  11. Development of Motor Bearings for a New SADA (BepiColombo)

    Science.gov (United States)

    Kreuser, J.; Bachman, R.; Bergrath, B.; Heinrich, B.; Zemann, J.

    2013-09-01

    The special requirements of the new MPO Solar Array Drive Assembly (SADA) developed for the BepiColombo program demanded also new ball bearing designs. In addition to typical requirements for other bearings in space mechanisms, the BepiColombo mission is characterized by a non-operating time of six years at extreme environmental conditions. In cooperation with RUAG Space CEROBEAR has developed different types of ball bearings for this SADA including motor bearings for the drive, a customized stepper motor.The purpose of this paper is to present and summarize the results of the development of the motor bearings of the SADA.

  12. Development of Motor-Life-Skills: Variations in Children at Risk for Motor Difficulties from the Toddler Age to Preschool Age

    Science.gov (United States)

    Moser, Thomas; Reikerås, Elin; Tønnessen, Finn Egil

    2018-01-01

    This article explores variations in development of everyday motor-life-skills in 661 children (329 girls and 332 boys) in Norwegian kindergartens of ages 2:9 (T1) and 4:9 (T2) years:months. The particular focus is on children at risk for problems in motor development (the 10% weakest children in the sample). The methodological approach chosen is…

  13. Liquid-Hydrogen-Cooled 450-hp Electric Motor Test Stand Being Developed

    Science.gov (United States)

    Kascak, Albert F.; Trudell, Jeffrey J.; Brown, Gerald V.

    2005-01-01

    With growing concerns about global warming, there is a need to develop pollution-free aircraft. One approach is to use hydrogen-fueled aircraft that use fuel cells or turbogenerators to produce electric power to drive the electric motors that turn the aircraft s propulsive fans. Hydrogen fuel would be carried as a liquid, stored at its boiling point of 20.5 K (-422.5 F). Conventional electric motors, however, are too heavy for aircraft propulsion. We need to develop high-power, lightweight electric motors (highpower- density motors). One approach is to increase the conductivity of the wires by cooling them with liquid hydrogen (LH2). This would allow superconducting rotors with an ironless core. In addition, the motor could use very pure aluminum or copper, substances that have low resistances at cryogenic temperatures. A preliminary design of a 450-hp LH2-cooled electric motor was completed and is being manufactured by a contractor. This motor will be tested at the NASA Glenn Research Center and will be used to test different superconducting materials such as magnesium diboride (MgB2). The motor will be able to operate at speeds of up to 6000 rpm.

  14. Delayed Development of Feeding Skills in Children with Feeding Difficulties—Cross-sectional Study in a Brazilian Reference Center

    Directory of Open Access Journals (Sweden)

    Cláudia C. Ramos

    2017-10-01

    Full Text Available BackgroundDelays in gross motor development, sensory processing issues, and organic and behavioral problems are known to interfere in the development of feeding skills (FS; and—therefore—in the success of the process of feeding a child. Children with feeding difficulties (FD commonly present inadequacy of FS.ObjectivesAssessment of five FS in Brazilian children with FD, and search of associations with types of FD.MethodsCross-sectional study with 70 children below 10 years old. Data were obtained from medical records: age, gender, age at texture transitions, feeding phase (breastfeeding, weaning to solids or full solids at first complaint; characteristics of the meal (duration, environment, and shared meals with adults, self-feeding practices, use of feeding equipment and bottle, mouthing, feeding position and FD diagnosis. Skills were categorized according to standards for age. Chi-Square, Anova Test (or non-parametric equivalent and Multinomial logistic regression tests were used, with a significance level of 5%.ResultsThere was no difference in FS (p > 0.05 or in the number of FS inadequateness (p = 0.84 according to FD diagnosis. The majority (94% of children presented at least one delayed development of FS; 1/3 presented delays in more than half of the FS. The most prevalent inadequacies in FS were inadequate feeding position (73.5%, prolonged bottle feeding (56.9%, and inadequate self-feeding practices (37.9%. Feeding complaints first appeared at 10.9 ± 11.4 months, and picky eating was the most prevalent type of FD (37.1%. Most children were fed in inadequate environments (55.2%, without the company of adults (78%. Transition to solid foods occurred at 16 ± 5.6 months. Multinomial logistic regression showed no difference in likelihood of presenting any type of FD compared to picky eating, according to FS. Age at texture transition both from breastfeeding to complementary feeding (p = 0.95, and from

  15. Development of Rotor Diagnosis Method via Motor Current Signature Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Park, Jin Seok; Huh, Hyung; Kim, Min Hwan; Jeong, Kyeong Hoon; Lee, Gyu Mhan; Park, Jin Ho; Park, Keun Bae; Lee, Cheol Kwon; Hur, S

    2006-01-15

    A study on motor current signature analysis has been performed to monitor a journal bearing fault due to increasing clearance. It was known that the journal bearing clearance produces side band frequencies, the supplied current frequency plus and minus rotational rotor frequency in motor current. But the existence information of the side band frequencies is not sufficient to diagnose whether the journal bearing is safe or not. Four journal bearing sets with different clearances are used to measure the side band frequency amplitude and the rotor vibration amplitude versus the journal bearing clearance. The side band frequency amplitude and the rotor vibration amplitude are increased as the journal bearing clearance is increasing. This trend assures that ASME OM vibration guide line can be applied to estimate the journal bearing clearance size. In this research, 2.5 times the reference side band amplitude is suggested as an indicator of a journal bearing fault. Further study is necessary to make out more specific quantitative relations between the side band frequency amplitude and the journal bearing clearance of a motor.

  16. Development of Rotor Diagnosis Method via Motor Current Signature Analysis

    International Nuclear Information System (INIS)

    Park, Jin Seok; Huh, Hyung; Kim, Min Hwan; Jeong, Kyeong Hoon; Lee, Gyu Mhan; Park, Jin Ho; Park, Keun Bae; Lee, Cheol Kwon; Hur, S.

    2006-01-01

    A study on motor current signature analysis has been performed to monitor a journal bearing fault due to increasing clearance. It was known that the journal bearing clearance produces side band frequencies, the supplied current frequency plus and minus rotational rotor frequency in motor current. But the existence information of the side band frequencies is not sufficient to diagnose whether the journal bearing is safe or not. Four journal bearing sets with different clearances are used to measure the side band frequency amplitude and the rotor vibration amplitude versus the journal bearing clearance. The side band frequency amplitude and the rotor vibration amplitude are increased as the journal bearing clearance is increasing. This trend assures that ASME OM vibration guide line can be applied to estimate the journal bearing clearance size. In this research, 2.5 times the reference side band amplitude is suggested as an indicator of a journal bearing fault. Further study is necessary to make out more specific quantitative relations between the side band frequency amplitude and the journal bearing clearance of a motor

  17. Motor and cognitive development: the role of karate.

    Science.gov (United States)

    Alesi, Marianha; Bianco, Antonino; Padulo, Johnny; Vella, Francesco Paolo; Petrucci, Marco; Paoli, Antonio; Palma, Antonio; Pepi, Annamaria

    2014-04-01

    regular physical activity has an effect on biological responses in both muscles and organs that, in turn, alter the structure and functions of the brain. Therefore, this study aims at comparing motor (sprint, coordination ability and explosive legs strength skills) and cognitive abilities (working memory, attention, executive functioning) in children. 39 children with average chronological age of 9 years were divided in: Karatekas (n=19) and Sedentary (n=20) groups. Their abilities were measured by motor and cognitive tests. Motor skills were assessed through a battery composed by the 20 mt Sprint test, the Agility test and the Standing board jump Test. Cognitive profile was assessed by a battery of tests derived from BVN 5-11, "Batteria di Valutazione Neuropsicologica per l'Et à Evolutiva": Visual discrimination test, Reaction time test, Forwards and Backwards Digit Span Tests, Corsi Block-Tapping test and Tower of London. our results reveal significant differences between two groups (p attention and executive functions. karate exercise training shows global benefits resulting in physiological and psychological gains in children.

  18. Development of a new generation solid rocket motor ignition computer code

    Science.gov (United States)

    Foster, Winfred A., Jr.; Jenkins, Rhonald M.; Ciucci, Alessandro; Johnson, Shelby D.

    1994-01-01

    This report presents the results of experimental and numerical investigations of the flow field in the head-end star grain slots of the Space Shuttle Solid Rocket Motor. This work provided the basis for the development of an improved solid rocket motor ignition transient code which is also described in this report. The correlation between the experimental and numerical results is excellent and provides a firm basis for the development of a fully three-dimensional solid rocket motor ignition transient computer code.

  19. Speech and language development in cognitively delayed children with cochlear implants.

    Science.gov (United States)

    Holt, Rachael Frush; Kirk, Karen Iler

    2005-04-01

    The primary goals of this investigation were to examine the speech and language development of deaf children with cochlear implants and mild cognitive delay and to compare their gains with those of children with cochlear implants who do not have this additional impairment. We retrospectively examined the speech and language development of 69 children with pre-lingual deafness. The experimental group consisted of 19 children with cognitive delays and no other disabilities (mean age at implantation = 38 months). The control group consisted of 50 children who did not have cognitive delays or any other identified disability. The control group was stratified by primary communication mode: half used total communication (mean age at implantation = 32 months) and the other half used oral communication (mean age at implantation = 26 months). Children were tested on a variety of standard speech and language measures and one test of auditory skill development at 6-month intervals. The results from each test were collapsed from blocks of two consecutive 6-month intervals to calculate group mean scores before implantation and at 1-year intervals after implantation. The children with cognitive delays and those without such delays demonstrated significant improvement in their speech and language skills over time on every test administered. Children with cognitive delays had significantly lower scores than typically developing children on two of the three measures of receptive and expressive language and had significantly slower rates of auditory-only sentence recognition development. Finally, there were no significant group differences in auditory skill development based on parental reports or in auditory-only or multimodal word recognition. The results suggest that deaf children with mild cognitive impairments benefit from cochlear implantation. Specifically, improvements are evident in their ability to perceive speech and in their reception and use of language. However, it may

  20. Delayed growth

    Science.gov (United States)

    ... Slow rate of growth; Retarded growth and development; Growth delay Images Toddler development References Cooke DW, Divall SA, Radovick S. Normal and aberrant growth in children. In: Melmed S, Polonsky KS, Larsen PR, ...

  1. Time-varying delays compensation algorithm for powertrain active damping of an electrified vehicle equipped with an axle motor during regenerative braking

    Science.gov (United States)

    Zhang, Junzhi; Li, Yutong; Lv, Chen; Gou, Jinfang; Yuan, Ye

    2017-03-01

    The flexibility of the electrified powertrain system elicits a negative effect upon the cooperative control performance between regenerative and hydraulic braking and the active damping control performance. Meanwhile, the connections among sensors, controllers, and actuators are realized via network communication, i.e., controller area network (CAN), that introduces time-varying delays and deteriorates the control performances of the closed-loop control systems. As such, the goal of this paper is to develop a control algorithm to cope with all these challenges. To this end, the models of the stochastic network induced time-varying delays, based on a real in-vehicle network topology and on a flexible electrified powertrain, were firstly built. In order to further enhance the control performances of active damping and cooperative control of regenerative and hydraulic braking, the time-varying delays compensation algorithm for the electrified powertrain active damping during regenerative braking was developed based on a predictive scheme. The augmented system is constructed and the H∞ performance is analyzed. Based on this analysis, the control gains are derived by solving a nonlinear minimization problem. The simulations and hardware-in-loop (HIL) tests were carried out to validate the effectiveness of the developed algorithm. The test results show that the active damping and cooperative control performances are enhanced significantly.

  2. Evaluation of motor and cognitive development among infants exposed to HIV.

    Science.gov (United States)

    da Silva, Kaitiana Martins; de Sá, Cristina Dos Santos Cardoso; Carvalho, Raquel

    2017-02-01

    This study of a prospective and cross-sectional nature compared the motor and cognitive development of HIV-exposed and unexposed infants in their first 18months of age. 40 infants exposed to HIV and antiretroviral therapy (Experimental Group - EG) and 40 unexposed infants (Control Group - CG) participated in the study. They were divided into four age groups of 4, 8, 12 and 18months old, with 10 infants from EG and 10 from CG in each group. The infants were evaluated once on motor and cognitive development by the Bayley Scale of Infant and Toddler Development. Performance category grading and comparisons among scaled score, composite score and percentile rank were held. There was significant group effect for scores in motor and cognitive domains showing lower scores for EG regardless of age. In comparison to the CG, the EG presented lower scores for cognitive domain at 8 and 18months. In the performance categories, all infants were classified at or above the average for motor and cognitive development, except of one EG-18month old infant classified as borderline for motor development. Infants exposed to HIV and antiretroviral therapy own adequate cognitive and motor development in the first 18months. However, the lower scores found, particularly on the 8th and 18th month for cognitive development, may indicate future problems, highlighting the need for systematic follow-up of this population. Copyright © 2017 Elsevier B.V. All rights reserved.

  3. A standardized motor imagery introduction program (MIIP) for neuro-rehabilitation: development and evaluation

    OpenAIRE

    Wondrusch, C.; Schuster-Amft, C.

    2013-01-01

    Background: For patients with central nervous system (CNS) lesions and sensorimotor impairments a solid motor imagery (MI) introduction is crucial to understand and use MI to improve motor performance. The study's aim was to develop and evaluate a standardized MI group introduction program (MIIP) for patients after stroke, multiple sclerosis (MS), Parkinson's disease (PD), and traumatic brain injury (TBI). Methods: Phase 1: Based on literature a MIIP was developed comprising MI theory (def...

  4. A standardized motor imagery introduction program (MIIP) for neuro-rehabilitation: development and evaluation

    OpenAIRE

    Christine eWondrusch; Corina eSchuster; Corina eSchuster

    2013-01-01

    Background: For patients with central nervous system lesions and sensorimotor impairments a solid motor imagery (MI) introduction is crucial to understand and use MI to improve motor performance. The study’s aim was to develop and evaluate a standardized MI group introduction program (MIIP) for patients after stroke, multiple sclerosis, Parkinson’s disease, and traumatic brain injury. Methods:Phase 1: Based on literature a MIIP was developed comprising MI theory (definition, type, mode, persp...

  5. A systematic review of clinimetric properties of measurements of motivation for children aged 5-16 years with a physical disability or motor delay.

    Science.gov (United States)

    Miller, Laura; Ziviani, Jenny; Boyd, Roslyn Nancy

    2014-02-01

    The purpose of this systematical review was to appraise the clinimetric properties of measures of motivation in children aged 5-16 years with a physical disability or motor delay. Six electronic databases were searched. Studies were included if they reported measuring motivation in school-aged children across occupational performance areas. Two reviewers independently identified measures from included articles. Evaluation of measures was completed using the COSMIN (consensus-based standards for the selection of health measurement instruments) checklist. A total of 13,529 papers were retrieved, 15 reporting measurement of motivation in this population. Two measures met criteria: Dimensions of Mastery Questionnaire (DMQ) and Pediatric Volitional Questionnaire (PVQ). There was evidence of adequate validity for DMQ, and preliminary evidence of test-retest reliability. Psychometric evidence for PVQ was poor. Both measures demonstrated good clinical utility. The large number of retrieved papers highlights the importance being attributed to motivation in clinical studies, although measurement is seldom performed. Both identified measures show promise but further psychometric research is required.

  6. Overweight and obese infants present lower cognitive and motor development scores than normal-weight peers.

    Science.gov (United States)

    Camargos, Ana Cristina Resende; Mendonça, Vanessa Amaral; Andrade, Camila Alves de; Oliveira, Katherine Simone Caires; Lacerda, Ana Cristina Rodrigues

    2016-12-01

    Compare the cognitive and motor development in overweight/obese infants versus normal-weight peers and investigate the correlation of body weight, body length and body mass index with cognitive and motor development. We conducted a cross-sectional study with 28 overweight/obese infants and 28 normal-weight peers between 6 and 24 months of age. Both groups were evaluated with cognitive and motor scales of the Bayley-III infant development test. The t-test for independent samples was performed to compare the groups, and the Spearman correlation was used to verify the association between variables. Overweight/obese infants showed lower cognitive and motor composite scores than their normal-weight peers. A significant negative association was found of body weight and body length with cognitive development and of body mass index with motor development. This is the first study that found an effect on both cognitive and motor development in overweight/obese infants when compared with normal-weight peers between 6 and 24 months of age. Copyright © 2016 Elsevier Ltd. All rights reserved.

  7. Delayed embryonic development in the Indian short-nosed fruit bat, Cynopterus sphinx.

    Science.gov (United States)

    Meenakumari, Karukayil J; Krishna, Amitabh

    2005-01-01

    The unusual feature of the breeding cycle of Cynopterus sphinx at Varanasi is the significant variation in gestation length of the two successive pregnancies of the year. The aim of this study was to investigate whether the prolongation of the first pregnancy in C. sphinx is due to delayed embryonic development. The first (winter) pregnancy commences in late October and lasts until late March and has a gestation period of about 150 days. The second (summer) pregnancy commences in April and lasts until the end of July or early August with a gestation period of about 125 days. Changes in the size and weight of uterine cornua during the two successive pregnancies suggest retarded embryonic growth during November and December. Histological analysis during the period of retarded embryonic development in November and December showed a slow gastrulation process. The process of amniogenesis was particularly slow. When the embryos attained the early primitive streak stage, their developmental rate suddenly increased considerably. During the summer pregnancy, on the other hand, the process of gastrulation was much faster and proceeded quickly. A comparison of the pattern of embryonic development for 4 consecutive years consistently showed retarded or delayed embryonic development during November and December. The time of parturition and post-partum oestrus showed only a limited variation from 1 year to another. This suggests that delayed embryonic development in C. sphinx may function to synchronize parturition among females. The period of delayed embryonic development in this species clearly coincides with the period of fat deposition. The significance of this correlation warrants further investigation.

  8. Oportunidades do ambiente domiciliar para o desenvolvimento motor Oportunidades del ambiente domiciliar para el desarrollo motor Opportunities in the home environment for motor development

    Directory of Open Access Journals (Sweden)

    Érica Cesário Defilipo

    2012-08-01

    Full Text Available OBJETIVO: Avaliar as oportunidades presentes no ambiente domiciliar para o desenvolvimento motor de lactentes. MÉTODOS: Estudo epidemiológico de base populacional, transversal, realizado com 239 lactentes com idade entre três e 18 meses, residentes no município de Juiz de Fora, MG, em 2010. Os participantes foram selecionados por amostragem aleatória estratificada, conglomerada, em múltiplos estágios. Para avaliar a qualidade e quantidade de estímulo motor no ambiente domiciliar foi utilizado o instrumento Affordance in the Home Environment for Motor Development - Infant Scale. Procedeu-se a análise bivariada com aplicação do teste qui-quadrado, seguida de regressão logística multinomial para verificar a associação entre as oportunidades presentes no domicílio e fatores biológicos, comportamentais, demográficos e socioeconômicos. RESULTADOS: As oportunidades de estimulação ambiental foram relativamente baixas. Na análise bivariada, para a faixa etária de três a nove meses, foi encontrada associação com os fatores: ordem de nascimento (p = 0,06, classificação socioeconômica (p = 0,08, renda mensal (p = 0,06 e renda per capita (p = 0,03. No modelo de regressão, prevaleceu a classificação socioeconômica (RC = 7,46; p = 0,03. Para a faixa etária de dez a 18 meses, os fatores associados, na análise bivariada, foram: estado civil materno (p OBJETIVO: Evaluar las oportunidades presentes en el ambiente domiciliar para el desarrollo motor de lactantes. MÉTODOS: Estudio epidemiológico de base poblacional, transversal, realizado con 239 lactantes con edad entre tres y 18 meses, residentes en el municipio de Juiz de Fora, Sureste de Brasil, en 2010. Los participantes se seleccionaron por muestreo aleatorio estratificado, conglomerado, en múltiples fases. Para evaluar la calidad y cantidad de estimulo motor en el ambiente domiciliar se utilizó el instrumento Affordance in the Home Environment for Motor Development

  9. Guided play and free play in an enriched environment: Impact on motor development

    Directory of Open Access Journals (Sweden)

    Míriam Stock Palma

    2014-06-01

    Full Text Available The purpose of this study was to investigate the effects of guided play and free play in an enriched environmentintervention programs using motor skill development in kindergarten children. Seventy-one children attending kindergarten classes were assigned to two experimental groups and one control group. Participants performed the Test of Gross Motor Development-2 before and after the intervention period. Results revealed that both boys and girls in the guided play group showed motor skill improvement, whereas no changes were observed in motor development in the boys and girls assigned to the free play in enriched environment group, nor in those in the control group. These findings indicate that the teacher's role in the guided play intervention was crucial to help preschool children to improve their performance.

  10. The Dutch motor skills assessment as tool for talent development in table tennis : a reproducibility and validity study

    NARCIS (Netherlands)

    Faber, Irene R.; Nijhuis-Van der Sanden, Maria W. G.; Elferink-Gemser, Marije T.; Oosterveld, Frits G. J.

    2015-01-01

    A motor skills assessment could be helpful in talent development by estimating essential perceptuo-motor skills of young players, which are considered requisite to develop excellent technical and tactical qualities. The Netherlands Table Tennis Association uses a motor skills assessment in their

  11. Motor Skill Abilities in Toddlers with Autistic Disorder, Pervasive Developmental Disorder-Not Otherwise Specified, and Atypical Development

    Science.gov (United States)

    Matson, Johnny L.; Mahan, Sara; Fodstad, Jill C.; Hess, Julie A.; Neal, Daniene

    2010-01-01

    Motor skills were assessed in 397 toddlers, and it was demonstrated that atypically developing toddlers exhibited significantly greater motor skill abilities than toddlers with autistic disorder. No significant difference on gross or fine motor skill abilities were found between atypically developing toddlers and toddlers with pervasive…

  12. The Dutch motor skills assessment as tool for talent development in table tennis: a reproducibility and validity study

    NARCIS (Netherlands)

    Faber, I.R.; Nijhuis-Van der Sanden, M.W.G.; Elferink-Gemser, M.T.; Oosterveld, F.G.

    2015-01-01

    A motor skills assessment could be helpful in talent development by estimating essential perceptuo-motor skills of young players, which are considered requisite to develop excellent technical and tactical qualities. The Netherlands Table Tennis Association uses a motor skills assessment in their

  13. The Dutch motor skills assessment as tool for talent development in table tennis: a reproducibility and validity study

    NARCIS (Netherlands)

    Faber, I.R.; Nijhuis-Van der Sanden, M.W.; Elferink-Gemser, M.T.; Oosterveld, F.G.J.

    2014-01-01

    Abstract A motor skills assessment could be helpful in talent development by estimating essential perceptuo-motor skills of young players, which are considered requisite to develop excellent technical and tactical qualities. The Netherlands Table Tennis Association uses a motor skills assessment in

  14. DEVELOPMENT OF MOTOR QUALITIES ADOLESCENTS IN IMPROVING COMPLEX

    Directory of Open Access Journals (Sweden)

    Abdullahat Rashidovich Mamaev

    2015-02-01

    Full Text Available The purpose of the study the actualization of the problem of improvement of children and adolescents in the wellness center, which consists in urgent need of modernization sports and recreation activities with adolescents 13-14 years in terms of stay in the health complex. The paper presents the survey of adolescents Romodanovskaya secondary school number 3 of the Republic of Mordovia. Identified motor abilities using tests of physical fitness. Application of the results will increase the efficiency of the process of physical education, positive impact on the formation of personality traits of adolescents and strengthen the health effect of physical exercise.

  15. Development of magneto-rheologial fluid (MRF) based clutch for output torque control of AC motors

    Science.gov (United States)

    Nguyen, Q. Hung; Do, H. M. Hieu; Nguyen, V. Quoc; Nguyen, N. Diep; Le, D. Thang

    2018-03-01

    In industry, the AC motor is widely used because of low price, power availability, low cost maintenance. The main disadvantages of AC motors compared to DC motors are difficulty in speed and torque control, requiring expensive controllers with complex control algorithms. This is the basic limitations in the widespread adoption of AC motor systems for industrial automation. One feasible solution for AC motor control is using MRF (magneto-rheological fluid) based clutches (shortly called MR clutches) Although there have been many studies on MR clutches, most of these clutches used traditional configuration with coils wound on the middle cylindrical part and a compotator is used to supply power to the coils. Therefore, this type of MR clutches possesses many disadvantages such as high friction and unstable applied current due to commutator, complex structure which causes difficulty in manufacture, assembly, and maintenance. In addition, the bottleneck problem of magnetic field is also a challenging issue. In this research, we will develop a new type of MR clutches that overcomes the abovementioned disadvantages of traditional MR clutches and more suitable for application in controlling of AC motor. Besides, in this study, speed and torque control system for AC motors using developed MR clutches is designed and experimental validated.

  16. THE ROLE OF DYNAMIC SYSTEMS IN MOTOR DEVELOPMENT RESEARCH. JUST A METAPHOR OR A NOTABLE REALITY?

    Directory of Open Access Journals (Sweden)

    Ivan Šerbetar

    2015-01-01

    Full Text Available In the present article an application of a new theory of motor control in the context of motor development theories and research has been discussed. In a brief overview of traditional theories of motor development a neuro-maturational theory is mentioned along with the two prominent proponents - McGraw & Gesell. Bernstein’s fundamental insights in motor control were emphasized, such as the concepts of degrees of freedom and synergies, along with his contribution to the measurement technology and quantification. Basic principles of dynamic systems theory and common concepts such as self-organization, patterns, attractors or non-equilibrium systems are briefly described. In the main part, an example of research in motor development carried out in dynamical perspective was introduced. The chosen example was the body of the research performed by Thelen et al. (1982, 1984, 1990 on a newborn’s stepping. The distinction between the maturational perspective in which all the sequences of motor development are the result of maturation of nervous system, and the dynamic perspective in which development is seen as a mutual interaction between a number of body systems, including neural and muscular systems, which continuously affect the movement although none of them dominate (Kamm et al., 1990 has been made.

  17. The attitudes of family physicians toward a child with delayed growth and development.

    Science.gov (United States)

    Aker, Servet; Şahin, Mustafa Kürşat; Kınalı, Ömer; Şimşek Karadağ, Elif; Korkmaz, Tuğba

    2017-09-01

    Aim The purpose of this study was to assess the attitude of family physicians toward a child with delayed growth and development. Primary healthcare professionals play a key role in monitoring growth and development, the best indicator of the child's health status. If delayed growth and development can be detected early, then it is usually possible to restore functioning. This descriptive study was performed in Samsun, Turkey, in May and June 2015. In total, 325 family physicians were included. The study consisted of two parts. In the first session of the research, the story of an 18-month-old child with delayed growth and development was presented using visual materials. An interview between the child's mother and a member of primary healthcare staff was then enacted by two of the authors using role-playing. Subsequently, participants were given the opportunity to ask the mother and member of primary healthcare staff questions about the case. During the sessions, two observers observed the participants, took notes and compared these after the presentation. In the second part of the study, the participants were asked to complete a questionnaire consisting of three open-ended questions. Findings When asking questions of the mother, family physicians generally used accusatory and judgmental language. One of the questions most commonly put to the mother was 'Do you think you are a good mother?' Family physicians were keen to provide instruction for the patient and relatives. Family physicians to a large extent thought that the problem of a child with delayed growth and development can be resolved through education. Family physicians' manner of establishing relations with the patient and relatives is inappropriate. We therefore think that they should receive on-going in-service training on the subject.

  18. Modulation of ovarian steroidogenesis by adiponectin during delayed embryonic development of Cynopterus sphinx.

    Science.gov (United States)

    Anuradha; Krishna, Amitabh

    2014-09-01

    The aim of present study was to evaluate role of adiponectin in ovarian steroidogenesis during delayed embryonic development of Cynopterus sphinx. This study showed significantly low circulating adiponectin level and a decline in expression of adiponectin receptor 1 (AdipoR1) in the ovary during the period of delayed embryonic development as compared with the normal development. The adiponectin treatment in vivo during the period of delayed development caused significantly increased in circulating progesterone and estradiol levels together with increased expression of AdipoR1 in the ovary. The in vitro study confirmed the stimulatory effect of adiponectin on progesterone synthesis. Both in vivo and in vitro studies showed that the effects of adiponectin on ovarian steroidogenesis were mediated through increased expression of luteinizing hormone-receptor, steroidogenic acute regulatory protein and 3β-hydroxyl steroid dehydrogenase enzyme. The adiponectin treatment may also promote progesterone synthesis by modulating ovarian angiogenesis, cell survival and rate of apoptosis. Copyright © 2014 Elsevier Ltd. All rights reserved.

  19. [Delayed identity development, family relationships and psychopathology: Links between healthy and clinically disturbed youth].

    Science.gov (United States)

    Seiffge-Krenke, Inge; Escher, Fabian J

    2018-05-01

    This study compared three groups of various age and health status (total N = 732) with respect to their identity status, stress level, and parental behavior. As expected, patients were characterized by delayed identity development, particularly ruminative exploration. Further, patients experienced high identity stress and described high levels of anxious paternal rearing and intrusive maternal psychological control. The patients‘ levels of both internalizing and externalizing symptomatology were high, and the impact of externalizing symptoms on identity arrest was strong. Identity status was delayed, albeit age adequate in both groups of healthy youths, with comparably high levels of anxious parental monitoring. Compared to adolescents, young adults were particularly active in their identity development, showing a high level of identity stress but no increase in psychopathology.

  20. Early gross motor skills predict the subsequent development of language in children with autism spectrum disorder.

    Science.gov (United States)

    Bedford, Rachael; Pickles, Andrew; Lord, Catherine

    2016-09-01

    Motor milestones such as the onset of walking are important developmental markers, not only for later motor skills but also for more widespread social-cognitive development. The aim of the current study was to test whether gross motor abilities, specifically the onset of walking, predicted the subsequent rate of language development in a large cohort of children with autism spectrum disorder (ASD). We ran growth curve models for expressive and receptive language measured at 2, 3, 5 and 9 years in 209 autistic children. Measures of gross motor, visual reception and autism symptoms were collected at the 2 year visit. In Model 1, walking onset was included as a predictor of the slope of language development. Model 2 included a measure of non-verbal IQ and autism symptom severity as covariates. The final model, Model 3, additionally covaried for gross motor ability. In the first model, parent-reported age of walking onset significantly predicted the subsequent rate of language development although the relationship became non-significant when gross motor skill, non-verbal ability and autism severity scores were included (Models 2 & 3). Gross motor score, however, did remain a significant predictor of both expressive and receptive language development. Taken together, the model results provide some evidence that early motor abilities in young children with ASD can have longitudinal cross-domain influences, potentially contributing, in part, to the linguistic difficulties that characterise ASD. Autism Res 2016, 9: 993-1001. © 2015 The Authors Autism Research published by Wiley Periodicals, Inc. on behalf of International Society for Autism Research. © 2015 The Authors Autism Research published by Wiley Periodicals, Inc. on behalf of International Society for Autism Research.

  1. Development and testing of a decision aid for women considering delayed breast reconstruction.

    Science.gov (United States)

    Metcalfe, Kelly; Zhong, Toni; O'Neill, Anne C; McCready, David; Chan, Linda; Butler, Kate; Brennenstuhl, Sarah; Hofer, Stefan O P

    2018-03-01

    The decision to have post-mastectomy breast reconstruction (PMBR) is highly complex and many women feel ill equipped to make this decision. Decision aids have been advocated to promote patient involvement in decision-making by streamlining and standardizing communication between the patient and the health care professional. In this study, we report on the development and testing of a decision aid (DA) for breast cancer survivors considering delayed PMBR. The DA was developed and evaluated in three phases. The first phase included the development of the DA with input and review by practitioners and key stakeholders. The second phase involved pilot testing of the feasibility and acceptability of the DA with a convenience sample of women with delayed PMBR. The third phase involved a pretest/post-test evaluation of the DA for women who were making decisions about their PMBR options. The DA was developed using the Ottawa Decision Support Framework. In the second phase of the study, 21 women completed the acceptability survey, of whom 100% reported that they would recommend the DA to other women. In the third phase, decisional conflict decreased significantly (p < 0.001) and knowledge increased significantly (p < 0.001) from prior to using the DA to 1-2 weeks after using the DA. The DA is feasible and acceptable to women considering delayed PMBR. Furthermore, the DA is effective at reducing decisional conflict and increasing knowledge about delayed PMBR. The DA is an appropriate tool to be used in addition with standard care in women considering PMBR. Copyright © 2017 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.

  2. Gross motor skill development of 5-year-old Kindergarten children in Myanmar.

    Science.gov (United States)

    Aye, Thanda; Oo, Khin Saw; Khin, Myo Thuzar; Kuramoto-Ahuja, Tsugumi; Maruyama, Hitoshi

    2017-10-01

    [Purpose] The purpose of this study was to examine the gross motor skill development of 5-year-old Kindergarten children in Myanmar. [Subjects and Methods] Total 472 healthy Kindergarten children (237 males, 235 females) of 2016-2017 academic year from four schools in urban area and four schools in rural area of Myanmar were recruited. The gross motor skill development of all subjects was assessed with the test of gross motor development second edition (TGMD-2). All subjects performed two trials for each gross motor skill and the performance was video recorded and scored. The assessment procedures were done according to the standardized guidelines of TGMD-2. [Results] The majority of subjects had average level of gross motor skill rank. The significant differences were found on the run and gallop of locomotor skills and the most of object control skills except the catch between males and females. The significant differences were also found between subjects from urban and rural areas. [Conclusion] Gross motor skill development of 5-year-old Kindergarten children in Myanmar had gender-based and region-based differences on both locomotor and object control skills. This study added a valuable information to the establishment of a normative reference of Kindergarten aged children for future studies.

  3. Simulation of Axial Combustion Instability Development and Suppression in Solid Rocket Motors

    OpenAIRE

    David R. Greatrix

    2009-01-01

    In the design of solid-propellant rocket motors, the ability to understand and predict the expected behaviour of a given motor under unsteady conditions is important. Research towards predicting, quantifying, and ultimately suppressing undesirable strong transient axial combustion instability symptoms necessitates a comprehensive numerical model for internal ballistic simulation under dynamic flow and combustion conditions. An updated numerical model incorporating recent developments in predi...

  4. Sport stacking activities in school children's motor skill development.

    Science.gov (United States)

    Li, Yuhua; Coleman, Diane; Ransdell, Mary; Coleman, Lyndsie; Irwin, Carol

    2011-10-01

    This study examined the impact of a 12-wk. sport stacking intervention on reaction time (RT), manual dexterity, and hand-eye coordination in elementary school-aged children. 80 Grade 2 students participated in a 15-min. sport stacking practice session every school day for 12 wk., and were tested on psychomotor performance improvement. Tests for choice RT, manual dexterity, and photoelectric rotary pursuit tracking were conducted pre- and post-intervention for both experimental group (n = 36) and the controls (n = 44) who did no sport stacking. Students who had the intervention showed a greater improvement in two-choice RT. No other group difference was found. Such sport stacking activities may facilitate children's central processing and perceptual-motor integration.

  5. Delayed Disease Onset and Extended Survival in the SOD1G93A Rat Model of Amyotrophic Lateral Sclerosis after Suppression of Mutant SOD1 in the Motor Cortex

    Science.gov (United States)

    Thomsen, Gretchen M.; Gowing, Genevieve; Latter, Jessica; Chen, Maximus; Vit, Jean-Philippe; Staggenborg, Kevin; Avalos, Pablo; Alkaslasi, Mor; Ferraiuolo, Laura; Likhite, Shibi; Kaspar, Brian K.

    2014-01-01

    Sporadic amyotrophic lateral sclerosis (ALS) is a fatal disease with unknown etiology, characterized by a progressive loss of motor neurons leading to paralysis and death typically within 3–5 years of onset. Recently, there has been remarkable progress in understanding inherited forms of ALS in which well defined mutations are known to cause the disease. Rodent models in which the superoxide dismutase-1 (SOD1) mutation is overexpressed recapitulate hallmark signs of ALS in patients. Early anatomical changes in mouse models of fALS are seen in the neuromuscular junctions (NMJs) and lower motor neurons, and selective reduction of toxic mutant SOD1 in the spinal cord and muscle of these models has beneficial effects. Therefore, much of ALS research has focused on spinal motor neuron and NMJ aspects of the disease. Here we show that, in the SOD1G93A rat model of ALS, spinal motor neuron loss occurs presymptomatically and before degeneration of ventral root axons and denervation of NMJs. Although overt cell death of corticospinal motor neurons does not occur until disease endpoint, we wanted to establish whether the upper motor neuron might still play a critical role in disease progression. Surprisingly, the knockdown of mutant SOD1 in only the motor cortex of presymptomatic SOD1G93A rats through targeted delivery of AAV9–SOD1–shRNA resulted in a significant delay of disease onset, expansion of lifespan, enhanced survival of spinal motor neurons, and maintenance of NMJs. This datum suggests an early dysfunction and thus an important role of the upper motor neuron in this animal model of ALS and perhaps patients with the disease. PMID:25411487

  6. Effects of music therapy in the treatment of children with delayed speech development - results of a pilot study

    OpenAIRE

    Linden Ulrike; Groß Wibke; Ostermann Thomas

    2010-01-01

    Abstract Background Language development is one of the most significant processes of early childhood development. Children with delayed speech development are more at risk of acquiring other cognitive, social-emotional, and school-related problems. Music therapy appears to facilitate speech development in children, even within a short period of time. The aim of this pilot study is to explore the effects of music therapy in children with delayed speech development. Methods A total of 18 childr...

  7. Parental practices and beliefs on motor development in the first year of life

    Directory of Open Access Journals (Sweden)

    Alcilene Maria Gomes

    Full Text Available Abstract Introduction: In the child’s first year of life, motor development is critical for the other areas of child development. Beliefs and parenting practices influence the parents’ care and encouragement of their children, reflecting in their motor development; however, the Brazilian literature on this subject is scarce. Objective: to characterize the parental practices and beliefs associated with motor development in the first year of life; and to verify if practices and beliefs are interrelated. Methods: Two questionnaires were developed and applied, one about parenting practices and the other about parental beliefs on motor development in the first year life, to 27 caregivers of children between 12 and 24 months of age, who participated in an aquatic stimulation program. The agreement between practices and beliefs was verified by a graphical method, based on the transformation of ordinal scores to an interval scale using Rasch analysis. Results: The participants had higher levels of education and economic status. They reported a variety of practices focused on the motor development of their children, such as family interaction through playing, toy offers, lap time and free movement space. Conclusion: Most of the practices were based on parental beliefs, for some activities, however, beliefs and practices diverged, demonstrating the complexity inherent to the formation of parental beliefs.

  8. Mental and motor development before and during growth hormone treatment in infants and toddlers with Prader-Willi syndrome.

    Science.gov (United States)

    Festen, D A M; Wevers, M; Lindgren, A C; Böhm, B; Otten, B J; Wit, J M; Duivenvoorden, H J; Hokken-Koelega, A C S

    2008-06-01

    Prader-Willi syndrome (PWS) is a neurogenetic disorder characterized by muscular hypotonia, psychomotor delay, feeding difficulties and failure to thrive in infancy. GH treatment improves growth velocity and body composition. Research on the effects of GH on psychomotor development in infants with PWS is limited. To evaluate psychomotor development in PWS infants and toddlers during GH treatment compared to randomized controls. Forty-three PWS infants were evaluated at baseline. Twenty-nine of them were randomized into a GH group (n = 15) receiving 1 mg/m(2)/day GH or a non-GH-treated control group (n = 14). At baseline and after 12 months of follow-up, analysis with Bayley Scales of Infant Development II (BSID-II) was performed. Data were converted to percentage of expected development for age (%ed), and changes during follow-up were calculated. Infants in the GH group had a median age of 2.3 years [interquartile range (IQR) 1.7-3.0] and in the control group of 1.5 years (IQR 1.2-2.7) (P = 0.17). Both mental and motor development improved significantly during the first year of study in the GH group vs. the control group: median (IQR) change was +9.3% (-5.3 to 13.3) vs.-2.9% (-8.1 to 4.9) (P development and +11.2% (-4.9 to 22.5) vs.-18.5% (-27.9 to 1.8) (P development, respectively. One year of GH treatment significantly improved mental and motor development in PWS infants compared to randomized controls.

  9. Virtual process of product development for electric motors; Virtueller Produktentwicklungsprozess fuer Elektromotoren

    Energy Technology Data Exchange (ETDEWEB)

    Schoening, Marc Christian

    2008-07-01

    In order to consider all relevant design aspects and their mutual interdependences, current design practice uses a selection of different software packages. The design tools as a rule specialize in a single design criterion, so that tools must be combined in order to consider the mutual interaction of electromagnetic, thermal, and acoustic effects. So far, this has been done individually and manually, with a new model of the motor under investigation generated in every single program. This means that the parameters of a motor must be managed several times. The publication presents a novel simulation tool which provides a comprehensive methodology in which all design aspects of electric motors are considered by a standardised and uniform virtual development process. Further, the virtual reality method is used for representing 3D motor models in their natural dimensions, thus providing better understanding of the numeric simulation results. (orig.)

  10. [Breastfeeding, gross motor development and obesity, is there any causal association?

    Science.gov (United States)

    Weisstaub N, Gerardo; Schonhaut B, Luisa; Salazar R, Gabriela

    2017-01-01

    Childhood obesity is the main nutritional and public health problem in Chile, being the principal causes, the increase in energy dense foods and the decline of physical activity. Interventions to prevent obesity at infancy are focused mainly in improving quality and quantity of dietary intake, without taking into account physical activity, which is expressed under two years of age, mainly by motor development. Some studies have proven that motor development at early age, may influence the ability to perform physical activity. Thus, infants scoring a lower motor development may have a greater risk of becoming obese. It isn’t know if childhood obesity causes lower motor development (given that children may have greater difficulty to move), or on the contrary, it is the lower ability to move, which increases the obesity risk. The objective of this manuscriptis analize the evidence regards the relation between breastfeeding, motor development and obesity in the childhood.To be able to understand this asocation and casual mecanism, it is important to develop stategys focused in early infancy to promote breastfeeding, healthy eating and early stimulation, starting in pediatric office.

  11. Challenges and Approaches for Developing Ultrafine Particle Emission Inventories for Motor Vehicle and Bus Fleets

    Directory of Open Access Journals (Sweden)

    Diane U. Keogh

    2011-03-01

    Full Text Available Motor vehicles in urban areas are the main source of ultrafine particles (diameters < 0.1 µm. Ultrafine particles are generally measured in terms of particle number because they have little mass and are prolific in terms of their numbers. These sized particles are of particular interest because of their ability to enter deep into the human respiratory system and contribute to negative health effects. Currently ultrafine particles are neither regularly monitored nor regulated by ambient air quality standards. Motor vehicle and bus fleet inventories, epidemiological studies and studies of the chemical composition of ultrafine particles are urgently needed to inform scientific debate and guide development of air quality standards and regulation to control this important pollution source. This article discusses some of the many challenges associated with modelling and quantifying ultrafine particle concentrations and emission rates for developing inventories and microscale modelling of motor vehicles and buses, including the challenge of understanding and quantifying secondary particle formation. Recommendations are made concerning the application of particle emission factors in developing ultrafine particle inventories for motor vehicle fleets. The article presents a précis of the first published inventory of ultrafine particles (particle number developed for the urban South-East Queensland motor vehicle and bus fleet in Australia, and comments on the applicability of the comprehensive set of average particle emission factors used in this inventory, for developing ultrafine particle (particle number and particle mass inventories in other developed countries.

  12. Parents' and speech and language therapists' explanatory models of language development, language delay and intervention.

    Science.gov (United States)

    Marshall, Julie; Goldbart, Juliet; Phillips, Julie

    2007-01-01

    Parental and speech and language therapist (SLT) explanatory models may affect engagement with speech and language therapy, but there has been dearth of research in this area. This study investigated parents' and SLTs' views about language development, delay and intervention in pre-school children with language delay. The aims were to describe, explore and explain the thoughts, understandings, perceptions, beliefs, knowledge and feelings held by: a group of parents from East Manchester, UK, whose pre-school children had been referred with suspected language delay; and SLTs working in the same area, in relation to language development, language delay and language intervention. A total of 24 unstructured interviews were carried out: 15 with parents whose children had been referred for speech and language therapy and nine with SLTs who worked with pre-school children. The interviews were transcribed verbatim and coded using Atlas/ti. The data were analysed, subjected to respondent validation, and grounded theories and principled descriptions developed to explain and describe parents' and SLTs' beliefs and views. Parent and SLT data are presented separately. There are commonalities and differences between the parents and the SLTs. Both groups believe that language development and delay are influenced by both external and internal factors. Parents give more weight to the role of gender, imitation and personality and value television and videos, whereas the SLTs value the 'right environment' and listening skills and consider that health/disability and socio-economic factors are important. Parents see themselves as experts on their child and have varied ideas about the role of SLTs, which do not always accord with SLTs' views. The parents and SLTs differ in their views of the roles of imitation and play in intervention. Parents typically try strategies before seeing an SLT. These data suggest that parents' ideas vary and that, although parents and SLTs may share some

  13. Delayed puberty in girls

    Science.gov (United States)

    ... sexual development - girls; Pubertal delay - girls; Constitutional delayed puberty ... In most cases of delayed puberty, growth changes just begin later than usual, sometimes called a late bloomer. Once puberty begins, it progresses normally. This pattern runs ...

  14. Fine Motor Development of Low Birth Weight Infants Corrected Aged 8 to 12 Months

    Directory of Open Access Journals (Sweden)

    Sepideh Nazi

    2012-10-01

    Full Text Available Objectives: The aim of this study was to compare the fine motor development between Low Birth Weight (LBW infants and Normal Birth Weight infants (NBW at the age of 8-12 months by using the Peabody Developmental Motor Scale-2 (PDMS-2 . Methods: This was a non experimental and cross sectional study which was conducted on the 18 LBW infants and 14 normal infants. By referring to the profile of infants in NICU of Aliasghar Hospital, those with defined inclusion criteria was recognized (case group. The normal weight infants, randomly selected from Health Center of that hospital, matched with case group for date of birth. After completing the questionnaire about demographic variables, their gross motor development was assessed with PDMS-2. Finally the scores of the motor quotient were analyzed by independent t-test statistical method. Results: There was a significant difference between Fine motor quotient of groups (P=0.007. Discussion: This study showed that LBW infants are significantly lower than normal weight infants in attaining Fine motor skills. It means that the LBW infants are more prone to developmental difficulties.

  15. Gross motor development in full-term Greek infants assessed by the Alberta Infant Motor Scale: reference values and socioeconomic impact.

    Science.gov (United States)

    Syrengelas, Dimitrios; Kalampoki, Vassiliki; Kleisiouni, Paraskevi; Konstantinou, Dimitrios; Siahanidou, Tania

    2014-07-01

    The aims of this study were to investigate gross motor development in Greek infants and establish AIMS percentile curves and to examine possible association of AIMS scores with socioeconomic parameters. Mean AIMS scores of 1068 healthy Greek full-term infants were compared at monthly age level with the respective mean scores of the Canadian normative sample. In a subgroup of 345 study participants, parents provided, via interview, information about family socioeconomic status. Multiple linear regression analysis was performed to evaluate the relationship of infant motor development with socioeconomic parameters. Mean AIMS scores did not differ significantly between Greek and Canadian infants in any of the 19 monthly levels of age. In multiple linear regression analysis, the educational level of the mother and also whether the infant was being raised by grandparents/babysitter were significantly associated with gross motor development (p=0.02 and psocioeconomic factors are associated with the infants' motor development. Copyright © 2014 Elsevier Ltd. All rights reserved.

  16. Longitudinal motor development of "apparently normal" high-risk infants at 18 months, 3 and 5 years.

    Science.gov (United States)

    Goyen, Traci Anne; Lui, Kei

    2002-12-01

    Motor development appears to be more affected by premature birth than other developmental domains, however few studies have specifically investigated the development of gross and fine motor skills in this population. To examine longitudinal motor development in a group of "apparently normal" high-risk infants. Developmental follow-up clinic in a perinatal centre. Longitudinal observational cohort study. Fifty-eight infants born less than 29 weeks gestation and/or 1000 g and without disabilities detected at 12 months. Longitudinal gross and fine motor skills at 18 months, 3 and 5 years using the Peabody Developmental Motor Scales. The HOME scale provided information of the home environment as a stimulus for development. A large proportion (54% at 18 months, 47% at 3 years and 64% at 5 years) of children continued to have fine motor deficits from 18 months to 5 years. The proportion of infants with gross motor deficits significantly increased over this period (14%, 33% and 81%, pmotor development was positively influenced by the quality of the home environment. A large proportion of high-risk infants continued to have fine motor deficits, reflecting an underlying problem with fine motor skills. The proportion of infants with gross motor deficits significantly increased, as test demands became more challenging. In addition, the development of gross and fine motor skills appears to be influenced differently by the home environment.

  17. Balance, Proprioception, and Gross Motor Development of Chinese Children Aged 3 to 6 Years.

    Science.gov (United States)

    Jiang, Gui-Ping; Jiao, Xi-Bian; Wu, Sheng-Kou; Ji, Zhong-Qiu; Liu, Wei-Tong; Chen, Xi; Wang, Hui-Hui

    2018-01-01

    The authors' aim was to find the features of balance, proprioception, and gross motor development of Chinese children 3-6 years old and their correlations, provide theoretical support for promoting children's motor development, and enrich the world theoretical system of motor development. This study used a Tekscan foot pressure measurement instrument (Tekscan, Inc., Boston, MA), walking on a balance beam, Xsens 3-dimensional positional measuring system (Xsens Technologies, Enschede, the Netherlands), and Test of Gross Motor Development-2 to assess static balance, dynamic balance, knee proprioception, and levels of gross motor development (GMD) of 3- to 6-year-old children (n = 60) in Beijing. The results are as follows: children had significant age differences in static balance, dynamic balance, proprioception, and levels of GMD; children had significant gender differences in static balance, proprioception, and levels of GMD; children's static balance, dynamic balance, and proprioception had a very significant positive correlation with GMD (p < .01), but no significant correlation with body mass index.

  18. Effects of Physical Activity on Motor Skills and Cognitive Development in Early Childhood: A Systematic Review

    Directory of Open Access Journals (Sweden)

    Nan Zeng

    2017-01-01

    Full Text Available Objective. This study synthesized literature concerning casual evidence of effects of various physical activity programs on motor skills and cognitive development in typically developed preschool children. Methods. Electronic databases were searched through July 2017. Peer-reviewed randomized controlled trials (RCTs examining the effectiveness of physical activity on motor skills and cognitive development in healthy young children (4–6 years were screened. Results. A total of 15 RCTs were included. Of the 10 studies assessing the effects of physical activity on motor skills, eight (80% reported significant improvements in motor performance and one observed mixed findings, but one failed to promote any beneficial outcomes. Of the five studies investigating the influence of physical activity on cognitive development, four (80% showed significant and positive changes in language learning, academic achievement, attention, and working memory. Notably, one indicated no significant improvements were observed after the intervention. Conclusions. Findings support causal evidence of effects of physical activity on both motor skills and cognitive development in preschool children. Given the shortage of available studies, future research with large representative samples is warranted to explore the relationships between physical activity and cognitive domains as well as strengthen and confirm the dose-response evidence in early childhood.

  19. Effects of Physical Activity on Motor Skills and Cognitive Development in Early Childhood: A Systematic Review.

    Science.gov (United States)

    Zeng, Nan; Ayyub, Mohammad; Sun, Haichun; Wen, Xu; Xiang, Ping; Gao, Zan

    2017-01-01

    This study synthesized literature concerning casual evidence of effects of various physical activity programs on motor skills and cognitive development in typically developed preschool children. Electronic databases were searched through July 2017. Peer-reviewed randomized controlled trials (RCTs) examining the effectiveness of physical activity on motor skills and cognitive development in healthy young children (4-6 years) were screened. A total of 15 RCTs were included. Of the 10 studies assessing the effects of physical activity on motor skills, eight (80%) reported significant improvements in motor performance and one observed mixed findings, but one failed to promote any beneficial outcomes. Of the five studies investigating the influence of physical activity on cognitive development, four (80%) showed significant and positive changes in language learning, academic achievement, attention, and working memory. Notably, one indicated no significant improvements were observed after the intervention. Findings support causal evidence of effects of physical activity on both motor skills and cognitive development in preschool children. Given the shortage of available studies, future research with large representative samples is warranted to explore the relationships between physical activity and cognitive domains as well as strengthen and confirm the dose-response evidence in early childhood.

  20. Association between obesity-related biomarkers and cognitive and motor development in infants.

    Science.gov (United States)

    Camargos, Ana Cristina R; Mendonça, Vanessa A; Oliveira, Katherine S C; de Andrade, Camila Alves; Leite, Hércules Ribeiro; da Fonseca, Sueli Ferreira; Vieira, Erica Leandro Marciano; Teixeira Júnior, Antônio Lúcio; Lacerda, Ana Cristina Rodrigues

    2017-05-15

    This study aimed to verify the association between obesity-related biomarkers and cognitive and motor development in infants between 6 and 24 months of age. A cross-sectional study was conducted with 50 infants and plasma levels of leptin, adiponectin, resistin, soluble tumor necrosis factor receptors 1 and 2 (sTNFR1 and sTNFR2), chemokines, brain-derived neurotrophic factor (BDNF), serum cortisol and redox status were measured. The Bayley-III test was utilized to evaluate cognitive and motor development, and multiple linear stepwise regression models were performed to verify the association between selected biomarkers and cognitive and motor development. A significant association was found among plasma leptin and sTNFR1 levels with cognitive composite scores, and these two independents variables together explained 37% of the variability of cognitive composite scores (p=0.001). Only plasma sTNFR1 levels were associated and explained 24% of the variability of motor composite scores (p=0.003). Plasma levels of sTNFR1 were associated with the increase in cognitive and motor development scores in infants between 6 and 24 months of age through a mechanism not directly related to excess body weight. Moreover, increase in plasma levels of leptin reduced the cognitive development in this age range. Copyright © 2017 Elsevier B.V. All rights reserved.

  1. Delayed Traumatic Intracranial Haemorrhage and Progressive Traumatic Brain Injury in a Major Referral Centre Based in a Developing Country

    Science.gov (United States)

    Jeng, Toh Charng; Haspani, Mohd Saffari Mohd; Adnan, Johari Siregar; Naing, Nyi Nyi

    2008-01-01

    A repeat Computer Tomographic (CT) brain after 24–48 hours from the 1st scanning is usually practiced in most hospitals in South East Asia where intracranial pressure monitoring (ICP) is routinely not done. This interval for repeat CT would be shortened if there was a deterioration in Glasgow Coma Scale (GCS). Most of the time the prognosis of any intervention may be too late especially in hospitals with high patient-to-doctor ratio causing high mortality and morbidity. The purpose of this study was to determine the important predictors for early detection of Delayed Traumatic Intracranial Haemorrhage (DTICH) and Progressive Traumatic Brain Injury (PTBI) before deterioration of GCS occurred, as well as the most ideal timing of repeated CT brain for patients admitted in Malaysian hospitals. A total of 81 patients were included in this study over a period of six months. The CT scan brain was studied by comparing the first and second CT brain to diagnose the presence of DTICH/PTBI. The predictors tested were categorised into patient factors, CT brain findings and laboratory investigations. The mean age was 33.1 ± 15.7 years with a male preponderance of 6.36:1. Among them, 81.5% were patients from road traffic accidents with Glasgow Coma Scale ranging from 4 – 15 (median of 12) upon admission. The mean time interval delay between trauma and first CT brain was 179.8 ± 121.3 minutes for the PTBI group. The DTICH group, 9.9% of the patients were found to have new intracranial clots. Significant predictors detected were different referral hospitals (p=0.02), total GCS status (p=0.026), motor component of GCS (p=0.043), haemoglobin level (p<0.001), platelet count (p=0.011) and time interval between trauma and first CT brain (p=0.022). In the PTBI group, 42.0% of the patients were found to have new changes (new clot occurrence, old clot expansion and oedema) in the repeat CT brain. Univariate statistical analysis revealed that age (p=0.03), race (p=0.035), types of

  2. Associations of biological factors and affordances in the home with infant motor development.

    Science.gov (United States)

    Saccani, Raquel; Valentini, Nadia C; Pereira, Keila Rg; Müller, Alessandra B; Gabbard, Carl

    2013-04-01

    Whereas considerable work has been published regarding biological factors associated with infant health, much less is known about the associations of environmental context with infant development - the focus of the present cross-sectional study. Data were collected on 561 infants, aged newborn to 18 months. Measures included the Affordances in the Home Environment for Motor Development-Infant Scale, Alberta Infant Motor Scale, and selected bio/medical factors. Correlation and regression were used to analyze the data. Home environmental factors were associated with children's motor development as much as some typically high-risk biologic factors. The home environment partially explained infant development outcomes and infants at risk could possibly be helped with a home assessment for affordances. © 2012 The Authors. Pediatrics International © 2012 Japan Pediatric Society.

  3. DEVELOPMENT OF SOME OF STUDENTS` MOTORIC ABILITIES AFTER TEN-DAY-SKIING COURSE

    Directory of Open Access Journals (Sweden)

    Ljubiša Lilić

    2007-05-01

    Full Text Available Considering the fact that one of the most fundamental tasks of training is developing motoric dimensions of sportsmen, the common goal of this work was to achieve relevant knowledge on the infl uence of ten-day-skiing course on students`* development and to establish their level. The special aim of this work was diagnosing the amount of some of the students` motoric abilities. According to the subjects, problems and goal of the research, there was a hypothesis put: motoric and morphological dimensions of students are coherent with their chrono logical growth and development ten-day-skiing course has signifi cant infl uence on developing some of the students` motoric abilities Besides remaining, the choice of examined samples was put under limits of organizational capacities for realizing researching procedure.It was necessary to insure required devices and standardized conditions under which planned research was supposed to be realized. The sample is taken from students` population implied in regular skiing course. Examined sample consists of thirty male students, each of which is twenty years old. Because of technical and organizational reasons it was not possible to diagnose the whole motoric range of tested students. Due to that a specifi c selection of tests was done and only six variables (that reliably predict levels of motoric abilities on which the training affects were taken: foot tapping, medicine ball throwing, pull-ups with undertaking, trunk lifting in 60 seconds and deep forward band. The level of students` motoric abilities after ten-day-skiing course is on a higher level then initial measuring, and we can certainly claim that it is the result of programmed training process during skiing course. According to the data gained from control and fi nal measuring you can fi nd out the effects of applied resources towards initial measuring.

  4. Assessment of global motor performance and gross and fine motor skills of infants attending day care centers.

    Science.gov (United States)

    Souza, Carolina T; Santos, Denise C C; Tolocka, Rute E; Baltieri, Letícia; Gibim, Nathália C; Habechian, Fernanda A P

    2010-01-01

    To analyze the global motor performance and the gross and fine motor skills of infants attending two public child care centers full-time. This was a longitudinal study that included 30 infants assessed at 12 and 17 months of age with the Motor Scale of the Bayley Scales of Infant and Toddler Development, Third Edition (Bayley-III). This scale allows the analysis of global motor performance, fine and gross motor performance, and the discrepancy between them. The Wilcoxon test and Spearman's correlation coefficient were used. Most of the participants showed global motor performance within the normal range, but below the reference mean at 12 and 17 months, with 30% classified as having "suspected delays" in at least one of the assessments. Gross motor development was poorer than fine motor development at 12 and at 17 months of age, with great discrepancy between these two subtests in the second assessment. A clear individual variability was observed in fine motor skills, with weak linear correlation between the first and the second assessment of this subtest. A lower individual variability was found in the gross motor skills and global motor performance with positive moderate correlation between assessments. Considering both performance measurements obtained at 12 and 17 months of age, four infants were identified as having a "possible delay in motor development". The study showed the need for closer attention to the motor development of children who attend day care centers during the first 17 months of life, with special attention to gross motor skills (which are considered an integral part of the child's overall development) and to children with suspected delays in two consecutive assessments.

  5. Motor Development and Physical Activity: A Longitudinal Discordant Twin-Pair Study.

    Science.gov (United States)

    Aaltonen, Sari; Latvala, Antti; Rose, Richard J; Pulkkinen, Lea; Kujala, Urho M; Kaprio, Jaakko; Silventoinen, Karri

    2015-10-01

    Previous longitudinal research suggests that motor proficiency in early life predicts physical activity in adulthood. Familial effects including genetic and environmental factors could explain the association, but no long-term follow-up studies have taken into account potential confounding by genetic and social family background. The present twin study investigated whether childhood motor skill development is associated with leisure-time physical activity levels in adulthood independent of family background. Altogether, 1550 twin pairs from the FinnTwin12 study and 1752 twin pairs from the FinnTwin16 study were included in the analysis. Childhood motor development was assessed by the parents' report of whether one of the co-twins had been ahead of the other in different indicators of motor skill development in childhood. Leisure-time physical activity (MET·h·d) was self-reported by the twins in young adulthood and adulthood. Statistical analyses included conditional and ordinary linear regression models within twin pairs. Using all activity-discordant twin pairs, the within-pair difference in a sum score of motor development in childhood predicted the within-pair difference in the leisure-time physical activity level in young adulthood (P men and women.

  6. Sit to Talk: Relation between Motor Skills and Language Development in Infancy.

    Science.gov (United States)

    Libertus, Klaus; Violi, Dominic A

    2016-01-01

    Relations between walking skills and language development have been reported in 10- to 14-month-old infants. However, whether earlier emerging motor milestones also affect language skills remains unknown. The current research fills this gap by examining the relation between reaching and sitting skills and later language development, respectively. Reaching and sitting were assessed eight times, starting when infants (N = 29) were around 3 months of age. All assessments were completed and recorded remotely via videoconference using Skype or FaceTime. Subsequently, infants' language and motor skills were assessed via parent questionnaires (Communicative Development Inventories and Early Motor Questionnaire) at 10 and 14 months of age. Results revealed a significant correlation between the emergence of sitting skills and receptive vocabulary size at 10 and 14 months of age. Regression analyses further confirmed this pattern and revealed that the emergence of sitting is a significant predictor of subsequent language development above and beyond influences of concurrent motor skills. These findings suggest that the onset of independent sitting may initiate a developmental cascade that results in increased language learning opportunities. Further, this study also demonstrates how infants' early motor skills can be assessed remotely using videoconference.

  7. Can Kinesiological Activities Change "Pure" Motor Development in Preschool Children during One School Year?

    Science.gov (United States)

    Krneta, Željko; Casals, Cristina; Bala, Gustav; Madić, Dejan; Pavlović, Slobodan; Drid, Patrik

    2015-07-01

    The purpose of this study was to evaluate the effects of an additional, organized, and more intensive kinesiological treatment on "pure" motor abilities in preschool children. In the present study an experimental treatment was carried out on a sample of 37 preschool boys by applying kinesiological activities. The 60 minute treatment was applied over a period of one school year (9 months), twice a week. A control group of 31 boys were trained according to the regular program for preschool institutions. Treatment effects were assessed by 8 motor ability tests and 5 anthropometric measures. The significant differences between the groups, which were observed after the final measurement and compared to the initial one, proved that the kinesiological treatment had a positive impact on the general development of "pure" motor abilities. The most significant effect of experimental kinesiological treatment was the improvement in whole body force, flexibility and coordination of preschool boys. These findings, obtained only in one school year, point to the importance of physical exercise and the application of additional kinesiological activities with various modalities, to improve motor development, even morphological growth and development in preschool children. The effects of the perennial application of kinesiological activities, under the supervision of kinesiological professionals, could be beneficial and could form the basis for a better biological and motor development in older age.

  8. Sit to talk: Relation between motor skills and language development in infancy

    Directory of Open Access Journals (Sweden)

    Klaus eLibertus

    2016-03-01

    Full Text Available Relations between walking skills and language development have been reported in 10- to 14-month-old infants. However, whether earlier emerging motor milestones also affect language skills remains unknown. The current research fills this gap by examining the relation between reaching and sitting skills and later language development respectively. Reaching and sitting were assessed eight times, starting when infants (N=29 were around three months of age. All assessments were completed and recorded remotely via videoconference using Skype or FaceTime. Subsequently, infants’ language and motor skills were assessed via parent questionnaires (Communicative Development Inventories and Early Motor Questionnaire at 10 and 14 months of age. Results revealed a significant correlation between the emergence of sitting skills and receptive vocabulary size at 10 and 14 months of age. Regression analyses further confirmed this pattern and revealed that the emergence of sitting is a significant predictor of subsequent language development above and beyond influences of concurrent motor skills. These findings suggest that the onset of independent sitting may initiate a developmental cascade that results in increased language learning opportunities. Further, this study also demonstrates how infants’ early motor skills can be assessed remotely using videoconference.

  9. Development of motors and drives for main coolant pump and CEDM

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Do Hyun; Ha, Hoi Doo; Park, Jung Woo; Koo, Dae Hyun; Chang, Ki Chan; Kim, Jong Moo; Kim, Won Ho; Rim, Geun Hie; Baek, Ju Won; Park, Doh Young; Hwang, Don Ha; Jeon, Jeong Woo [Korea Electrotechnology Research Institute, Changwon (Korea)

    1999-03-01

    A canned type 170kW induction motor for the main coolant pump (MCP) of the integral reactor SMART was designed to minimize the eddy current loss in the can and the volume of motor. In order to verify the design and analysis methodology, a canned type 30kW induction motor and an inverter were developed and tested. The motor was designed to have two poles with squirrel cage solid rotor and open slot stator. The motor driver was designed as VVVF inverter to operate both at 900(r.p.m) and at 3600(r.p.m). The calculated design values showed a good agreement with the experimental results. The measured efficiencies of the canned motor and the inverter were 70(%) and 96(%), respectively. A variable reluctance type linear pulse motor (LPM) with double air-gaps for the Control Element Drive Mechanism (CEDM) to lift 100kg was designed, analyzed, manufactured and tested. A converter and a test facility were manufactured to verity the dynamic performance of the LPM. The mover of the LPM was welded with magnetic material(SUS430) and non-magnetic material(SUS304) to get flux path between inner stator and outer stator. The measured thrust force was about 20(%) less than the designed thrust force. As for the rotary stepping motors for CEDM-II, which have transverse flux pattern, three design options were proposed with thrust force density of 8kN/m{sup 2}, 14kN/m{sup 2} and 52kN/m{sup 2} respectively. (author). 31 refs., 219 figs., 60 tabs.

  10. Luteal cell steroidogenesis in relation to delayed embryonic development in the Indian short-nosed fruit bat, Cynopterus sphinx.

    Science.gov (United States)

    Meenakumari, Karukayil J; Banerjee, Arnab; Krishna, Amitabh

    2009-01-01

    The primary aim of this study was to determine the possible cause of slow or delayed embryonic development in Cynopterus sphinx by investigating morphological and steroidogenic changes in the corpus luteum (CL) and circulating hormone concentrations during two pregnancies of a year. This species showed delayed post-implantational embryonic development during gastrulation of the first pregnancy. Morphological features of the CL showed normal luteinization during both pregnancies. The CL did not change significantly in luteal cell size during the delay period of the first pregnancy as compared with the second pregnancy. The circulating progesterone and 17beta-estradiol concentrations were significantly lower during the period of delayed embryonic development as compared with the same stage of embryonic development during the second pregnancy. We also showed a marked decline in the activity of 3beta-hydroxysteroid dehydrogenase, P450 side chain cleavage enzyme, and steroidogenic acute regulatory peptide in the CL during the delay period. This may cause low circulating progesterone and estradiol synthesis and consequently delay embryonic development. What causes the decrease in steroidogenic factors in the CL during the period of delayed development in C. sphinx is under investigation.

  11. Ramathibodi Language Development Questionnaire: A Newly Developed Screening Tool for Detection of Delayed Language Development in Children Aged 18-30 Months.

    Science.gov (United States)

    Chuthapisith, Jariya; Wantanakorn, Pornchanok; Roongpraiwan, Rawiwan

    2015-08-01

    To develop a parental questionnaire for screening children with delayed language development in primary care settings. Ramathibodi Language Development (RLD) questionnaire was developed and completed by groups of 40 typically developing children age 18 to 30 months old and 30 children with delayed language development. The mean score was significantly lower in the delay language group (6.7 ± 1.9), comparing with the typically developing group (9.6 ± 0.7). The optimal ROC curve cut-off score was 8 with corresponding sensitivity and specificity were 98% and 72%, respectively. The corresponding area under the curve was 0.96 (95% CI = 0.92-0.99). The RLD questionnaire was the promising language developmental screening instrument that easily utilized in well-child examination settings.

  12. Development of Displacement Gages Exposed to Solid Rocket Motor Internal Environments

    Science.gov (United States)

    Bolton, D. E.; Cook, D. J.

    2003-01-01

    The Space Shuttle Reusable Solid Rocket Motor (RSRM) has three non-vented segment-to-segment case field joints. These joints use an interference fit J-joint that is bonded at assembly with a Pressure Sensitive Adhesive (PSA) inboard of redundant O-ring seals. Full-scale motor and sub-scale test article experience has shown that the ability to preclude gas leakage past the J-joint is a function of PSA type, joint moisture from pre-assembly humidity exposure, and the magnitude of joint displacement during motor operation. To more accurately determine the axial displacements at the J-joints, two thermally durable displacement gages (one mechanical and one electrical) were designed and developed. The mechanical displacement gage concept was generated first as a non-electrical, self-contained gage to capture the maximum magnitude of the J-joint motion. When it became feasible, the electrical displacement gage concept was generated second as a real-time linear displacement gage. Both of these gages were refined in development testing that included hot internal solid rocket motor environments and simulated vibration environments. As a result of this gage development effort, joint motions have been measured in static fired RSRM J-joints where intentional venting was produced (Flight Support Motor #8, FSM-8) and nominal non-vented behavior occurred (FSM-9 and FSM-10). This data gives new insight into the nominal characteristics of the three case J-joint positions (forward, center and aft) and characteristics of some case J-joints that became vented during motor operation. The data supports previous structural model predictions. These gages will also be useful in evaluating J-joint motion differences in a five-segment Space Shuttle solid rocket motor.

  13. Assessment of gait in toddlers with normal motor development and in hemiplegic children with mild motor impairment: a validity study

    Directory of Open Access Journals (Sweden)

    Priscilla R. P. Figueiredo

    2013-08-01

    Full Text Available BACKGROUND: The optimization of gait performance is an important goal in the rehabilitation of children with cerebral palsy (CP who present a prognosis associated with locomotion. Gait analysis using videos captured by digital cameras requires validation. OBJECTIVE: To evaluate the validity of a method that involves the analysis of videos captured using a digital camera for quantifying the temporal parameters of gait in toddlers with normal motor development and children with CP. METHOD: Eleven toddlers with normal motor development and eight children with spastic hemiplegia who were able to walk without assistive devices were asked to walk through a space contained in the visual field of two instruments: a digital camera and a three-dimensional motion analysis system, Qualisys Pro-Reflex. The duration of the stance and swing phases of gait and of the entire gait cycle were calculated by analyzing videos captured by a digital camera and compared to those obtained by Qualisys Pro-Reflex, which is considered a highly accurate system. RESULTS: The Intraclass Correlation Coefficient (ICC demonstrated excellent agreement (ICC>0.90 between the two procedures for all measurements, except for the swing phase of the normal toddlers (ICC=0.35. The standard error of measurement was less than 0.02 seconds for all measures. CONCLUSIONS: The results reveal similarities between the two instruments, suggesting that digital cameras can be valid instruments for quantifying two temporal parameters of gait. This congruence is of clinical and scientific relevance and validates the use of digital cameras as a resource for helping the assessment and documentation of the therapeutic effects of interventions targeted at the gait of children with CP.

  14. In-operation inspection technology development-4 ''development of degradation prediction technology for motor-operated valves''

    International Nuclear Information System (INIS)

    Kikuo, Takeshima; Yuichi, Higashikawa; Masahiro, Koike; Kenji, Matsumoto; Eiji, O'shima

    2001-01-01

    A method for degradation predicting technology has been proposed for motor operated valves in nuclear power plants which is based on the concept of condition monitoring for maintenance. This method (degradation prediction technology) eliminates the unnecessary overhaul of valves and realizes high reliability and economy. The degradation mechanism was clarified by long time heating experiments of gasket and gland packing and the wear test for them and stem nut to research valve parts degradation by stress (pressure, temperature, etc) during plant operation. Effective electric power measurements for motor operated valves were confirmed to be useful discovering valve part failures. The motor operated valve degradation prediction system was developed on the basis of the experiment results and mechanism. The system is able to predict the degradation of valve parts (gasket/gland packing, stem, stem nut, etc) utilizing plant data (pressure, temperature, etc) and effective power of the motor. The life of valve parts can be estimated from the experimental results. (authors)

  15. Factors affecting development of motor skills in extremely low birth weight children.

    Science.gov (United States)

    O'Connor, Anna R; Birch, Eileen E; Spencer, Rand

    2009-01-01

    The aim of this study is to analyze the impact of ophthalmic and neonatal factors on motor development in extremely low birth weight (ELBW) children. Sixty-four ELBW children at least 3 years of age were recruited. Visual acuity (VA) was assessed using the Teller acuity cards (TACs) and a letter test, if possible. A validated questionnaire assessing 25 fine (part A) and 20 gross motor (part B) skills was administered to the parents. Data were collected on retinopathy of prematurity (ROP) zone, intraventricular haemorrhage (IVH), length of stay in hospital, and number of days on oxygen. Abnormal TAC acuity was associated with significantly lower scores on both parts A and B (part A: 21.5 versus 11.8, p development, particularly fine motor development.

  16. A longitudinal study on gross motor development in children with learning disorders

    NARCIS (Netherlands)

    Westendorp, Marieke; Hartman, Esther; Houwen, Suzanne; Huijgen, Barbara C. H.; Smith, Joanne; Visscher, Chris

    This longitudinal study examined the development of gross motor skills, and sex-differences therein, in 7; to 11-years-old children with learning disorders (LD) and compared the results with typically developing children to determine the performance level of children with LD. In children with LD (n

  17. Gender Differences in Fundamental Motor Skill Development in Disadvantaged Preschoolers from Two Geographical Regions

    Science.gov (United States)

    Goodway, Jacqueline D.; Robinson, Leah E.; Crowe, Heather

    2010-01-01

    This study examined the influence of gender and region on object control (OC) and locomotor skill development. Participants were 275 midwestern African American and 194 southwestern Hispanic preschool children who were disadvantaged. All were evaluated on the Test of Gross Motor Development-2 (Ulrich, 2000). Two, 2 Gender (girls, boys) x 2 Region…

  18. Longitudinal development of gross motor function among Dutch children and young adults with cerebral palsy: an investigation of motor growth curves.

    Science.gov (United States)

    Smits, Dirk-Wouter; Gorter, Jan Willem; Hanna, Steven E; Dallmeijer, Annet J; van Eck, Mirjam; Roebroeck, Marij E; Vos, Rimke C; Ketelaar, Marjolijn

    2013-04-01

    The aim of this study was to describe patterns for gross motor development by level of severity in a Dutch population of individuals with cerebral palsy (CP). This longitudinal study included 423 individuals (260 males, 163 females) with CP. The mean age at baseline was 9 years 6 months (SD 6y 2mo, range 1-22y). The level of severity of CP among participants, according to the Gross Motor Function Classification System (GMFCS), was 50% level I, 13% level II, 14% level III, 13% level IV, and 10% level V. Participants had been assessed up to four times with the Gross Motor Function Measure (GMFM-66) at 1- or 2-year intervals between 2002 and 2009. Data were analysed using non-linear mixed effects modelling. For each GMFCS level, patterns were created by contrasting a stable limit model (SLM) with a peak and decline model (PDM), followed by estimating limits and rates of gross motor development. The SLM showed a better fit for all GMFCS levels than the PDM. Within the SLM, significant differences between GMFCS levels were found for both the limits (higher values for lower GMFCS levels) and the rates (higher values for GMFCS levels I-II vs level IV and for GMFCS levels I-IV vs level V) of gross motor development. The results validate the existence of five distinct patterns for gross motor development by level of severity of CP. ©The Authors. Developmental Medicine & Child Neurology © 2013 Mac Keith Press.

  19. A longitudinal study on gross motor development in children with learning disorders.

    Science.gov (United States)

    Westendorp, Marieke; Hartman, Esther; Houwen, Suzanne; Huijgen, Barbara C H; Smith, Joanne; Visscher, Chris

    2014-02-01

    This longitudinal study examined the development of gross motor skills, and sex-differences therein, in 7- to 11-years-old children with learning disorders (LD) and compared the results with typically developing children to determine the performance level of children with LD. In children with LD (n=56; 39 boys, 17 girls), gross motor skills were assessed with the Test of Gross Motor Development-2 and measured annually during a 3-year period. Motor scores of 253 typically developing children (125 boys, 112 girls) were collected for references values. The multilevel analyses showed that the ball skills of children with LD improved with age (p50). Boys had higher ball skill scores than girls (p=.002) and these differences were constant over time. Typically developing children outperformed the children with LD on the locomotor skills and ball skills at all ages, except the locomotor skills at age 7. Children with LD develop their ball skills later in the primary school-period compared to typically developing peers. However, 11 year-old children with LD had a lag in locomotor skills and ball skills of at least four and three years, respectively, compared to their peers. Copyright © 2013 Elsevier Ltd. All rights reserved.

  20. Development of Pointing Gestures in Children With Typical and Delayed Language Acquisition.

    Science.gov (United States)

    Lüke, Carina; Ritterfeld, Ute; Grimminger, Angela; Liszkowski, Ulf; Rohlfing, Katharina J

    2017-11-09

    This longitudinal study compared the development of hand and index-finger pointing in children with typical language development (TD) and children with language delay (LD). First, we examined whether the number and the form of pointing gestures during the second year of life are potential indicators of later LD. Second, we analyzed the influence of caregivers' gestural and verbal input on children's communicative development. Thirty children with TD and 10 children with LD were observed together with their primary caregivers in a seminatural setting in 5 sessions between the ages of 12 and 21 months. Language skills were assessed at 24 months. Compared with children with TD, children with LD used fewer index-finger points at 12 and 14 months but more pointing gestures in total at 21 months. There were no significant differences in verbal or gestural input between caregivers of children with or without LD. Using more index-finger points at the beginning of the second year of life is associated with TD, whereas using more pointing gestures at the end of the second year of life is associated with delayed acquisition. Neither the verbal nor gestural input of caregivers accounted for differences in children's skills.

  1. Motor Skill Development in Italian Pre-School Children Induced by Structured Activities in a Specific Playground.

    Directory of Open Access Journals (Sweden)

    Patrizia Tortella

    Full Text Available This study examined the effects and specificity of structured and unstructured activities played at the playground Primo Sport 0246 in Northern Italy on motor skill competence in five years old children. The playground was specifically designed to promote gross motor skills in preschool children; in this study 71 children from local kindergartens came to the park once a week for ten consecutive weeks and were exposed to 30 minutes of free play and 30 minutes of structured activities. Before and after the ten visits, each child completed nine tests to assess levels of motor skills, three for fine-motor skills and six for gross-motor skills. As control, motor skills were also assessed on 39 children from different kindergartens who did not come to the park. The results show that the experimental group who practiced gross-motor activities in the playground for 1 hour a week for 10 weeks improved significantly in 4 out of the 6 gross motor tasks and in none of the fine motor tasks. The data indicate that limited transfer occurred between tasks referring to different domains of motor competences while suggesting cross feeding for improvement of gross-motor skills between different exercises when domains related to physical fitness and strength of specific muscle groups are involved. These results are relevant to the issue of condition(s appropriate for maintaining and developing motor skills in this age group as well as for the planning, organization and implementation of play and physical activities in kindergartens.

  2. Motor Skill Development in Italian Pre-School Children Induced by Structured Activities in a Specific Playground.

    Science.gov (United States)

    Tortella, Patrizia; Haga, Monika; Loras, Håvard; Sigmundsson, Hermundur; Fumagalli, Guido

    2016-01-01

    This study examined the effects and specificity of structured and unstructured activities played at the playground Primo Sport 0246 in Northern Italy on motor skill competence in five years old children. The playground was specifically designed to promote gross motor skills in preschool children; in this study 71 children from local kindergartens came to the park once a week for ten consecutive weeks and were exposed to 30 minutes of free play and 30 minutes of structured activities. Before and after the ten visits, each child completed nine tests to assess levels of motor skills, three for fine-motor skills and six for gross-motor skills. As control, motor skills were also assessed on 39 children from different kindergartens who did not come to the park. The results show that the experimental group who practiced gross-motor activities in the playground for 1 hour a week for 10 weeks improved significantly in 4 out of the 6 gross motor tasks and in none of the fine motor tasks. The data indicate that limited transfer occurred between tasks referring to different domains of motor competences while suggesting cross feeding for improvement of gross-motor skills between different exercises when domains related to physical fitness and strength of specific muscle groups are involved. These results are relevant to the issue of condition(s) appropriate for maintaining and developing motor skills in this age group as well as for the planning, organization and implementation of play and physical activities in kindergartens.

  3. Motor Skill Development in Italian Pre-School Children Induced by Structured Activities in a Specific Playground

    Science.gov (United States)

    Tortella, Patrizia; Haga, Monika; Loras, Håvard

    2016-01-01

    This study examined the effects and specificity of structured and unstructured activities played at the playground Primo Sport 0246 in Northern Italy on motor skill competence in five years old children. The playground was specifically designed to promote gross motor skills in preschool children; in this study 71 children from local kindergartens came to the park once a week for ten consecutive weeks and were exposed to 30 minutes of free play and 30 minutes of structured activities. Before and after the ten visits, each child completed nine tests to assess levels of motor skills, three for fine-motor skills and six for gross-motor skills. As control, motor skills were also assessed on 39 children from different kindergartens who did not come to the park. The results show that the experimental group who practiced gross-motor activities in the playground for 1 hour a week for 10 weeks improved significantly in 4 out of the 6 gross motor tasks and in none of the fine motor tasks. The data indicate that limited transfer occurred between tasks referring to different domains of motor competences while suggesting cross feeding for improvement of gross-motor skills between different exercises when domains related to physical fitness and strength of specific muscle groups are involved. These results are relevant to the issue of condition(s) appropriate for maintaining and developing motor skills in this age group as well as for the planning, organization and implementation of play and physical activities in kindergartens. PMID:27462985

  4. Effect of Spark Motor Program on the development of gross motor skills in intellectually disabled educable boys

    Directory of Open Access Journals (Sweden)

    Hashem Faal Moganloo

    2013-11-01

    Results: Spark Program caused significant changes in all the variables of the study, except speed and agility, in the experimental group after 24 sessions. The changes included: agility and speed (P=0.731, balance (P=0, strength (P=0.002, and bilateral coordination (P=0. Conclusion: Spark Motor Program can improve gross motor skills in intellectually disabled educable students.

  5. Advanced axial field D.C. motor development for electric passenger vehicle

    Science.gov (United States)

    Jones, W. J.

    1982-01-01

    A wound-field axial-flux dc motor was developed for an electric vehicle drive system. The motor is essentially an axial-flux version of the classical Gramme-ring winding motor, but the active conductors are recessed into slots cut into the two opposite faces of the laminated tape-wound core ring. Three motors were built and tested in the program. The second (functional) model was a six-pole machine which weighed 88.5 kg. It developed 16.9 km (33.0 hp), and a max speed of 4800 rpm. Full load efficiency was 92% and predicted SAE D-cycle efficiency was 88%. The last engineering) model was a 4-pole machine with compoles, allowing a weight reduction to 45 kg (100 lbs.) while addressing some manufacturability problems. The engineering model was rated at 13.2 kw (17.6 hp) at 3000 rpm, with a peak power of 19.8 km (26.4 hp) and a max speed of 7200 rpm. Initial test results on this motor showed poor commutation and efficiency; the program was terminated without resolution of these problems.

  6. Development and validation of a new kind of coupling element for wheel-hub motors

    Science.gov (United States)

    Perekopskiy, Sergey; Kasper, Roland

    2018-05-01

    For the automotive industry, electric powered vehicles are becoming an increasingly relevant factor in the competition against climate change. Application of one special example - a wheel-hub motor, for electric powered vehicle can support this challenge. Patented slotless air gap winding invented at the chair of mechatronics of the Otto von Guericke University Magdeburg has great application potential in constantly growing e-mobility field, especially for wheel-hub motors based on this technology due to its advantages, such as a high gravimetric power density and high efficiency. However, advantages of this technology are decreased by its sensibility to the loads out of driving maneuvers by dimensional variations of air gap consistency. This article describes the development and validation of a coupling element for the designed wheel-hub motor. To find a suitable coupling concept first the assembly structure of the motor was analyzed and developed design of the coupling element was checked. Based on the geometry of the motor and wheel a detailed design of the coupling element was generated. The analytical approach for coupling element describes a potential of the possible loads on the coupling element. The FEM simulation of critical load cases for the coupling element validated results of the analytical approach.

  7. Ibuprofen or piroxicam protects nigral neurons and delays the development of l-dopa induced dyskinesia in rats with experimental Parkinsonism: Influence on angiogenesis.

    Science.gov (United States)

    Teema, Asmaa M; Zaitone, Sawsan A; Moustafa, Yasser M

    2016-08-01

    Neuroinflammation and angiogenesis have been involved in the pathogenesis of Parkinson's disease (PD). This study investigated the effect of ibuprofen or piroxicam on the motor response to l-dopa and development of dyskinesia in Parkinsonian rats focusing on the anti-angiogenic role of the two non-steroidal anti-inflammatory drugs (NSAIDs). Rats were divided into nine groups as follows: Group I: the vehicle group, Group II: rotenone group, rats were injected with nine doses of rotenone (1 mg/kg/48 h), group III&IV: rats received rotenone + ibuprofen (10 or 30 mg/kg), Group V-VI: rats received rotenone + piroxicam (1 or 3 mg/kg), Group VII: rats received rotenone + l-dopa/carbidopa (100/10 mg/kg), Group VIII-IX: rats received rotenone + l-dopa/carbidopa + ibuprofen (30 mg/kg) or piroxicam (3 mg/kg). In general, drugs were administered daily for ten weeks. Rotenone-treated rats showed motor dysfunction, lower striatal dopamine, lower staining for nigral tyrosine hydroxylase but higher level of striatal cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) compared to vehicle-treated rats (P piroxicam in combination with l-dopa preserved the effect of l-dopa at the end of week 10, delayed the development of dyskinesia and decreased striatal COX-2 and VEGF levels. In conclusion, the current study suggests that ibuprofen and piroxicam are promising candidates for neuroprotection in PD and may have utility in conjunction with l-dopa in order to ensure the longevity of its action and to delay the development of dyskinesia. Copyright © 2016 Elsevier Ltd. All rights reserved.

  8. The role of pre-school children motor behavior in developing their self-concept

    Directory of Open Access Journals (Sweden)

    Perić Dušan

    2014-01-01

    Full Text Available The assessment of motor behavior and general intellectual abilities were performed on a sample of 42 pre-school children (22 boys and 20 girls aged 6 (±3 months; moreover, the self-concept of those children was analysed. For the assessment of their motor behavior six movement tasks were chosen and the Mary Gutrich scale was applied for the analysis of the results. The children's intellectual abilities were assessed by the means of Raven's colored progressive matrices so as to enable the groups to homogenise, as well as to eliminate potential parasite factors when drawing conclusions. The self-concept analysis was performed using the pshychological interview during the course of which the children described their impression of their own abilities with regard to the past, present and future. The data related to the self-concept were complemented with the analysis of the children's drawings. The statistical analysis of the data gathered showed that motor behavior plays a significant role in developing one's self-concept, which is especially true of boys. Even though there is no significant statistical difference between boys and girls with respect to the quality of their motor behavior, there are significant differences between them pertaining to the vocabulary they use when describing their own selves, i.e. their self-concept, especially with respect to the present and future. Boys seem to use more extensive motor-related vocabulary when describing themselves, especially those with greater motor skills. Both boys and girls show a tendency to describe themselves as incapable in the past. When describing their present moment capabilities, girls tend to use vocabulary related to play and independence, whereas they mostly use vocabulary related to professions and sex roles when referring to the future. These findings indicate that social factors are of immense importance from a very early age, especially among girls. Moreover, the results show that

  9. Seasonal life history trade-offs in two leafwing butterflies: Delaying reproductive development increases life expectancy.

    Science.gov (United States)

    McElderry, Robert M

    2016-04-01

    Surviving inhospitable periods or seasons may greatly affect fitness. Evidence of this exists in the prevalence of dormant stages in the life cycles of most insects. Here I focused on butterflies with distinct seasonal morphological types (not a genetic polymorphism) in which one morphological type, or form, delays reproduction until favorable conditions return, while the other form develops in an environment that favors direct reproduction. For two butterflies, Anaea aidea and A. andria, I tested the hypothesis that the development of each seasonal form involves a differential allocation of resources to survival at eclosion. I assayed differences in adult longevity among summer and winter forms in either a warm, active environment or a cool, calm environment. Winter form adults lived 40 times longer than summer form but only in calm, cool conditions. The magnitude of this difference provided compelling evidence that the winter form body plan and metabolic strategy (i.e. resource conservatism) favor long term survival. This research suggests that winter form adults maintain lowered metabolic rate, a common feature of diapause, to conserve resources and delay senescence while overwintering. Copyright © 2016 Elsevier Ltd. All rights reserved.

  10. How do maternal subclinical symptoms influence infant motor development during the first year of life?

    Directory of Open Access Journals (Sweden)

    Giulia Piallini

    2016-11-01

    Full Text Available An unavoidable reciprocal influence characterizes mother-infant’s dyad.Within this relationship,the presence of depression,somatization,hostility,paranoid ideation and interpersonal sensitivity symptoms at a subclinical level and their possible input on infant motor competences has not been yet considered.Bearing in mind that motor abilities represent not only an indicator of infant’s health-status,but also the principal field to infer his/her needs, eelings and intentions,in this study the quality of infants’movements were assessed and analyzed in relationship with the maternal attitudes.The aim of this research was to investigate if/how maternal symptomatology may lead infant's motor development during his/her first year of life by observing the characteristics of motor development in infants aged 0-11months.Participants included 123 mothers and their infants (0-11months-old.Mothers’ symptomatology was screened with SymptomChecklist-90-Revised(SCL-90-R,while infants were tested with Peabody Developmental Motor Scale-Second Edition.All dyads belonged to a non-clinical population, however,on the basis of SCL-90-Rscores, mothers’sample was divided into two groups: normative and subclinical.Descriptive,T-test,correlational analysis between PDMS-2scores and SCL-90-R results are reported,as well as regression models results.Both positive and negative correlations were found between maternal perceived symptomatology,Somatization(SOM,Interpersonal Sensitivity(IS,Depression(DEP,Hostility(HOSand Paranoid Ideation(PARand infants’motor abilities.These results were then further verified by applying regression models to predict the infant motor outcomes on the basis of babies’ age and maternal status.The presence of positive symptoms in SCL-90-Rquestionnaire (subclinical group predicted good visual-motor integration and stationary competences in the babies.In particular,depressive and hostility feelings in mothers seemed to induce an infant

  11. Effect of zinc intake on mental and motor development in infants: a meta-analysis.

    Science.gov (United States)

    Nissensohn, Mariela; Sánchez-Villegas, Almudena; Fuentes Lugo, Daniel; Henríquez Sánchez, Patricia; Doreste Alonso, Jorge; Skinner, Anna L; Medina, Marisol W; Lowe, Nicola M; Hall Moran, Victoria; Serra-Majem, Lluis

    2013-01-01

    A systematic review and meta-analysis of available randomized controlled trials (RCTs) was conducted to evaluate the effect of zinc (Zn) intake on mental and motor development in infants. Out of 5500 studies identified through electronic searches and reference lists, 5 RCTs were selected after applying the exclusion/inclusion criteria. The influence of Zn intake on mental and motor development was considered in the overall meta-analysis. Other variables were also taken into account as possible effect modifiers: doses of Zn intake, intervention duration, nutritional situation, and risk of bias. Indices of mental and motor development assessed were the Mental Development Index (MDI) and Psychomotor Development Index (PDI). Additionally we carried out a sensitivity analysis. The pooled β was -0.01 (95 %CI -0.02, 0) for MDI and 0 (95 %CI -0.03, 0.02) for PDI, with a substantial heterogeneity in both analyses. When we performed a meta-regression, the effect of Zn supplementation on MDI changed depending on the dose of supplementation. Regarding PDI, there was a differential effect of Zn intake depending on intervention duration, dose of supplementation, nutritional situation, and risk of bias. Zn supplementation showed a negative, weak and significant effect on PDI score in those studies with a length of 4 to 20 weeks (β= -0.05; CI 95 % -0.06 to -0.04). In conclusion, no association was found between Zn intake and mental and motor development in infants. Further standardized research is urgently needed to clarify the role of Zn supplementation upon infant mental and motor development, particularly in Europe.

  12. Characterization of fine motor development: dynamic analysis of children's drawing movements.

    Science.gov (United States)

    Lin, Qiushi; Luo, Jianfei; Wu, Zhongcheng; Shen, Fei; Sun, Zengwu

    2015-04-01

    In this study, we investigated children's fine motor development by analyzing drawing trajectories, kinematics and kinetics. Straight lines drawing task and circles drawing task were performed by using a force sensitive tablet. Forty right-handed and Chinese mother-tongue students aged 6-12, attending classes from grade 1 to 5, were engaged in the experiment. Three spatial parameters, namely cumulative trace length, vector length of straight line and vertical diameter of circle were determined. Drawing duration, mean drawing velocity, and number of peaks in stroke velocity profile (NPV) were derived as kinematic parameters. Besides mean normal force, two kinetic indices were proposed: normalized force angle regulation (NFR) and variation of fine motor control (VFC) for circles drawing task. The maturation and automation of fine motor ability were reflected by increased drawing velocity, reduced drawing duration, NPV and NFR, with decreased VFC in circles drawing task. Grade and task main effects as well as significant correlations between age and parameters suggest that factors such as schooling, age and task should be considered in the assessment of fine motor skills. Compared with kinematic parameters, findings of NFR and VFC revealed that kinetics is another important perspective in the analysis of fine motor movement. Copyright © 2014 Elsevier B.V. All rights reserved.

  13. Development of a hermetically sealed brushless DC motor for a J-T cryocooler

    Science.gov (United States)

    Joscelyn, Edwin; Hochler, Irwin; Ferri, Andrew; Rott, Heinz; Soukaris, Ted

    1996-01-01

    This development was sponsored by Ball Aerospace for the Cryogenic On-Orbit LongLife Active Refrigerator (COOLLAR) program. The cryocooler is designed to cool objects to 65 K and operate in space for at least 7 years. The system also imports minimal impact to the spacecraft in terms of vibration and heat. The basic Joule-Thompson cycle involves compressing a working fluid, nitrogen in this case, at near-constant temperature from 17.2 KPa to 6.89 MPa. The nitrogen is then expanded through a Joule-Thompson valve. The pure nitrogen gas must be kept clean; therefore, any contamination from motor organic materials must be eliminated. This requirement drove the design towards sealing of the motor within a titanium housing without sacrificing motor performance. It is estimated that an unsealed motor would have contributed 1.65 g of contaminants, due to the organic insulation and potting materials, over the 7-year life. This paper describes the motor electrical and mechanical design, as well as the sealing difficulties encountered, along with their solutions.

  14. The Motor and Cognitive Development of Overweight Preschool Children

    Science.gov (United States)

    Krombholz, Heinz

    2012-01-01

    The aim of this study was to investigate the development of overweight compared with healthy-weight children attending kindergartens in Munich, Germany. Mean age of the children at the beginning of the study was 53.2 months (SD = 7.5); the duration of the study was 20 months. At the beginning of the study children were classified as overweight (n…

  15. Normative data on mental and motor development in Nigerian children

    African Journals Online (AJOL)

    Background: In Nigeria and sub-Saharan Africa at large, there has been heavy reliance on the “Caucasian data” in the developmental assessment of children. Hence, this study set out to establish normative data for psychomotor development on Nigerian children. Study design: One hundred and twenty eight children ...

  16. Development of a Forward Model for the Assimilation of Delay-Doppler Maps (DDMs)

    Science.gov (United States)

    Garrison, J. L.; Huang, F.; Leidner, M.; Annane, B.; Hoffman, R.

    2017-12-01

    Ocean wind measurements from CYGNSS have the potential to improve the observation and analysis of tropical cyclones globally. The standard Level-2 wind product, however, is defined by the 25-km spatial resolution requirement using only 15 out of a total of 187 delay-Doppler bins. The full forward model relating a surface wind field to the delay-Doppler map (DDM) involves a surface integral over the glistening zone (which can be expressed in a variety of more numerically efficient convolutional forms) and incorporates variation of the receiver antenna pattern over the surface. Combined with the well-known ambiguity in the mapping between surface coordinates and delay-Doppler space, this model cannot be inverted to provide wind speed estimates away from the specular point. Two approaches are being studied to improve wind retrievals through use of the full DDM. The first uses sequential DDM measurements which cover a large common area on the sea surface, but provide some variation in geometry due to satellite motion. An Extended Kalman filter (EKF) is used to integrate these sequential observations. Numerical simulations have been performed to show the sensitivity of the filter stability to the initial covariance matrix. Although it was found that the EKF wind field still retains artifacts of the delay-Doppler ambiguity, the wind speed at the specular point can be estimated with lower error than that of the baseline Level 2 products. Another approach is to assimilate DDMs directly into a 2-dimensional, Variational vector wind Analysis Method (VAM). Sample results from this forward model will be generated from idealized and real wind fields, and compared to results from the CYGNSS Science Team End-to-End simulator (E2ES). In both of these approaches, an accurate forward model for the calibrated level 1a DDM data is required. This presentation will emphasize the development of this model and the results of testing the forward model through comparison with early CYGNSS

  17. Motor Development of Premature Infants Born between 32 and 34 Weeks

    Directory of Open Access Journals (Sweden)

    S. A. Prins

    2010-01-01

    Full Text Available Little is known about motor development in late preterm born infants. Our objective was to determine long-term outcome of motor skills of infants born between 32 and 34 weeks. All infants were assessed at corrected ages of 3 and 9 months, using the Alberta Infant Motor Scale. At corrected ages of 4 years, the Movement Assessment Battery for Children was done. Seventy infants were seen at 4 years of age (median of 3 assessments per infant. Abnormal assessment at 3 or 9 months of age resulted in normal outcome in almost 80% at 4 years. On the other hand, a normal outcome in the first year of life resulted in an abnormal outcome at 4 years in 10% of the infants. Our results suggest that long-term followup of these late preterm born infants is necessary, as the assessments in the first year do not predict the long-term outcome.

  18. Simulation of Axial Combustion Instability Development and Suppression in Solid Rocket Motors

    Directory of Open Access Journals (Sweden)

    David R. Greatrix

    2009-03-01

    Full Text Available In the design of solid-propellant rocket motors, the ability to understand and predict the expected behaviour of a given motor under unsteady conditions is important. Research towards predicting, quantifying, and ultimately suppressing undesirable strong transient axial combustion instability symptoms necessitates a comprehensive numerical model for internal ballistic simulation under dynamic flow and combustion conditions. An updated numerical model incorporating recent developments in predicting negative and positive erosive burning, and transient, frequency-dependent combustion response, in conjunction with pressure-dependent and acceleration-dependent burning, is applied to the investigation of instability-related behaviour in a small cylindrical-grain motor. Pertinent key factors, like the initial pressure disturbance magnitude and the propellant's net surface heat release, are evaluated with respect to their influence on the production of instability symptoms. Two traditional suppression techniques, axial transitions in grain geometry and inert particle loading, are in turn evaluated with respect to suppressing these axial instability symptoms.

  19. Modified Delphi Investigation of Motor Development and Learning in Physical Education Teacher Education

    Science.gov (United States)

    Ross, Susan; Metcalf, Amanda; Bulger, Sean M.; Housner, Lynn D.

    2014-01-01

    Purpose: As the scope of motor development and learning knowledge has successfully broadened over the years, there is an increased need to identify the content and learning experiences that are essential in preparing preservice physical educators. The purpose of this study was to generate expert consensus regarding the most critical motor…

  20. Osteogenesis imperfecta: profiles of motor development as assessed by a postal questionnaire

    NARCIS (Netherlands)

    Engelbert, R. H.; Uiterwaal, C. S.; Gulmans, V. A.; Pruijs, H. E.; Helders, P. J.

    2000-01-01

    This study was performed to achieve more detailed information regarding the age and sequence in the development of motor milestones in the different types of osteogenesis imperfecta (OI). The parents of 98 patients with a diagnosis of OI were sent a questionnaire regarding the age at which patients

  1. Osteogenesis imperfecta : profiles of motor development as assessed by a postal questionnaire

    NARCIS (Netherlands)

    Engelbert, RHH; Uiterwaal, CSPM; Gulmans, VAM; Pruijs, HEH; Helders, PJM

    This study was performed to achieve more detailed information regarding the age and sequence in the development of motor milestones in the different types of osteogenesis imperfecta (OI). The parents of 98 patients with a diagnosis of OI were sent a questionnaire regarding the age at which patients

  2. Development of Early Handwriting: Visual-Motor Control during Letter Copying

    Science.gov (United States)

    Maldarelli, Jennifer E.; Kahrs, Björn A.; Hunt, Sarah C.; Lockman, Jeffrey J.

    2015-01-01

    Despite the importance of handwriting for school readiness and early academic progress, prior research on the development of handwriting has focused primarily on the product rather than the process by which young children write letters. In contrast, in the present work, early handwriting is viewed as involving a suite of perceptual, motor, and…

  3. Educational Gymnastics: The Effectiveness of Montessori Practical Life Activities in Developing Fine Motor Skills in Kindergartners

    Science.gov (United States)

    Bhatia, Punum; Davis, Alan; Shamas-Brandt, Ellen

    2015-01-01

    Research Findings: A quasi-experiment was undertaken to test the effect of Montessori practical life activities on kindergarten children's fine motor development and hand dominance over an 8-month period. Participants were 50 children age 5 in 4 Montessori schools and 50 students age 5 in a kindergarten program in a high-performing suburban…

  4. Development of EPICS based beam-line experimental control employing motor controller for precision positioning

    International Nuclear Information System (INIS)

    Tuli, Anupriya; Jain, Rajiv; Vora, H.S.

    2015-01-01

    In a Synchrotron Radiation Source the beamline experiments are carried out in radiation prone environment, inside the hutch, which demands to conduct experiments remotely. These experiments involves instrument control and data acquisition from various devices. Another factor which attributes to system complexity is precise positioning of sample and placement of detectors. A large number of stepper motors are engaged for achieving the required precision positioning. This work is a result of development of Experimental Physics and Industrial Control System (EPICS) based control system to interface a stepper motor controller developed indigenously by Laser Electronics Support Division of RRCAT. EPICS is an internationally accepted open source software environment which follows toolkit approach and standard model paradigm. The operator interface for the control system software was implemented using CSS BOY. The system was successfully tested for Ethernet based remote access. The developed control software comprises of an OPI and alarm handler (EPICS ALH). Both OPI and ALH are linked with PV's defined in database files. The development process resulted into a set of EPICS based commands for controlling stepper motor. These commands are independent of operator interface, i.e. stepper motor can be controlled by using these set of commands directly on EPICS prompt. This command set is illustrated in the above table. EPICS Alarm Handler was also tested independently by running these commands on EPIC prompt. If not using ALH, operator can read the alarm status of a PV using 'SEVR' and 'STAT' attributes. (author)

  5. Delayed Ego Strength Development in Opioid Dependent Adolescents and Young Adults

    Science.gov (United States)

    Abramoff, Benjamin A.; Lange, Hannah L. H.; Matson, Steven C.; Cottrill, Casey B.; Bridge, Jeffrey A.; Abdel-Rasoul, Mahmoud; Bonny, Andrea E.

    2015-01-01

    Objective. To evaluate ego strengths, in the context of Erikson's framework, among adolescents and young adults diagnosed with opioid dependence as compared to non-drug using youth. Methods. Opioid dependent (n = 51) and non-drug using control (n = 31) youth completed the self-administered Psychosocial Inventory of Ego Strengths (PIES). The PIES assesses development in the framework of Erikson's ego strength stages. Multivariate linear regression modeling assessed the independent association of the primary covariate (opioid dependent versus control) as well as potential confounding variables (e.g., psychiatric comorbidities, intelligence) with total PIES score. Results. Mean total PIES score was significantly lower in opioid dependent youth (231.65 ± 30.39 opioid dependent versus 270.67 ± 30.06 control; p development. A treatment approach acknowledging this delay may be needed in the counseling and treatment of adolescents with opioid dependence. PMID:26664819

  6. Target tissue influences on cholinergic development of parasympathetic motor neurons

    International Nuclear Information System (INIS)

    Tuttle, J.B.; Pilar, G.

    1986-01-01

    The normal function of neurons in the nervous system depends upon the orderly formation and maintenance of appropriate connections with other neurons and with non-neural target tissues. Having formed an appropriate synapse, the authors attempt to find how the interaction influences the subsequent program of neuronal differentiation and survival. The studies were made on neurons from the avian ciliary ganglion and their terminals in the iris. Concomitantly in time with the shift from an embryonic, fatiguable junction to the mature, more secure transmission, there is a large change in the capacity for ACh synthesis measured using radiolableled substrate. Only at this point in development does one detect and increase in the amount of tritium-ACh synthesized from tritium-choline in response to a pre-conditioning depolarization. The studies of development in vivo have provided a description of the steps taking place during maturation of a neuromuscular junction

  7. Optimized energy-delay sub-network routing protocol development and implementation for wireless sensor networks

    International Nuclear Information System (INIS)

    Fonda, James W; Zawodniok, Maciej; Jagannathan, S; Watkins, Steve E

    2008-01-01

    The development and the implementation issues of a reactive optimized energy-delay sub-network routing (OEDSR) protocol for wireless sensor networks (WSN) are introduced and its performance is contrasted with the popular ad hoc on-demand distance vector (AODV) routing protocol. Analytical results illustrate the performance of the proposed OEDSR protocol, while experimental results utilizing a hardware testbed under various scenarios demonstrate improvements in energy efficiency of the OEDSR protocol. A hardware platform constructed at the University of Missouri-Rolla (UMR), now the Missouri University of Science and Technology (MST), based on the Generation 4 Smart Sensor Node (G4-SSN) prototyping platform is also described. Performance improvements are shown in terms of end-to-end (E2E) delay, throughput, route-set-up time and drop rates and energy usage is given for three topologies, including a mobile topology. Additionally, results from the hardware testbed provide valuable lessons for network deployments. Under testing OEDSR provides a factor of ten improvement in the energy used in the routing session and extends network lifetime compared to AODV. Depletion experiments show that the time until the first node failure is extended by a factor of three with the network depleting and network lifetime is extended by 6.7%

  8. Alpha-1 antitrypsin protein and gene therapies decrease autoimmunity and delay arthritis development in mouse model

    Directory of Open Access Journals (Sweden)

    Atkinson Mark A

    2011-02-01

    Full Text Available Abstract Background Alpha-1 antitrypsin (AAT is a multi-functional protein that has anti-inflammatory and tissue protective properties. We previously reported that human AAT (hAAT gene therapy prevented autoimmune diabetes in non-obese diabetic (NOD mice and suppressed arthritis development in combination with doxycycline in mice. In the present study we investigated the feasibility of hAAT monotherapy for the treatment of chronic arthritis in collagen-induced arthritis (CIA, a mouse model of rheumatoid arthritis (RA. Methods DBA/1 mice were immunized with bovine type II collagen (bCII to induce arthritis. These mice were pretreated either with hAAT protein or with recombinant adeno-associated virus vector expressing hAAT (rAAV-hAAT. Control groups received saline injections. Arthritis development was evaluated by prevalence of arthritis and arthritic index. Serum levels of B-cell activating factor of the TNF-α family (BAFF, antibodies against both bovine (bCII and mouse collagen II (mCII were tested by ELISA. Results Human AAT protein therapy as well as recombinant adeno-associated virus (rAAV8-mediated hAAT gene therapy significantly delayed onset and ameliorated disease development of arthritis in CIA mouse model. Importantly, hAAT therapies significantly reduced serum levels of BAFF and autoantibodies against bCII and mCII, suggesting that the effects are mediated via B-cells, at least partially. Conclusion These results present a new drug for arthritis therapy. Human AAT protein and gene therapies are able to ameliorate and delay arthritis development and reduce autoimmunity, indicating promising potential of these therapies as a new treatment strategy for RA.

  9. Delayed Development of Brain Connectivity in Adolescents With Schizophrenia and Their Unaffected Siblings.

    Science.gov (United States)

    Zalesky, Andrew; Pantelis, Christos; Cropley, Vanessa; Fornito, Alex; Cocchi, Luca; McAdams, Harrison; Clasen, Liv; Greenstein, Deanna; Rapoport, Judith L; Gogtay, Nitin

    2015-09-01

    Abnormalities in structural brain connectivity have been observed in patients with schizophrenia. Mapping these abnormalities longitudinally and understanding their genetic risk via sibship studies will provide crucial insight into progressive developmental changes associated with schizophrenia. To identify corticocortical connections exhibiting an altered developmental trajectory in adolescents with childhood-onset schizophrenia (COS) and to determine whether similar alterations are found in patients' unaffected siblings. Using prospective structural brain magnetic resonance imaging, large-scale corticocortical connectivity was mapped from ages 12 to 24 years in 109 patients with COS (272 images), 86 of their unaffected siblings (184 images), and 102 healthy controls (262 images) over a 20-year period beginning January 1, 1991, through April 30, 2011, as part of the ongoing COS study at the National Institute of Mental Health. Structural connectivity between pairs of cortical regions was estimated using a validated technique based on across-subject covariation in magnetic resonance imaging-derived cortical thickness measurements. Compared with normally developing controls, significant left-hemisphere occipitotemporal deficits in cortical thickness correlations were found in patients with COS as well as their healthy siblings (P siblings normalized by mid-adolescence, whereas patients with COS showed significantly longer maturational delays, with cortical thickness correlations between the left temporal lobe and left occipital cortex not showing evidence of development until early adulthood. The normalization of deficits with age in patients with COS correlated with improvement in symptoms. Compared with controls, left-hemisphere occipitotemporal thickness correlations in a subgroup of patients with high positive symptoms were significantly reduced from age 14 to 18 years (P siblings associated with resilience to developing schizophrenia. These findings indicate

  10. Glycoconjugates distribution during developing mouse spinal cord motor organizers.

    Science.gov (United States)

    Vojoudi, Elham; Ebrahimi, Vahid; Ebrahimzadeh-Bideskan, Alireza; Fazel, Alireza

    2015-01-01

    The aim of this research was to study the distribution and changes of glycoconjugates particularly their terminal sugars by using lectin histochemistry during mouse spinal cord development. Formalin-fixed sections of mouse embryo (10-16 fetal days) were processed for lectin histochemical method. In this study, two groups of horseradish peroxidase-labeled specific lectins were used: N-acetylgalactosamine, including Dolichos biflorus, Wisteria floribunda agglutinin (WFA), Vicia villosa, Glycine max as well as focuse-binding lectins, including tetragonolobus, Ulex europaeus, and Orange peel fungus (OFA). All sections were counterstained with alcian blue (pH 2.5). Our results showed that only WFA and OFA reacted strongly with the floor plate cells from early to late embryonic period of developing spinal cord. The strongest reactions were related to the 14, 15, and 16 days of tissue sections incubated with OFA and WFA lectins. The present study demonstrated that cellular and molecular differentiation of the spinal cord organizers is a wholly regulated process, and α-L-fucose, α-D-GalNAc, and α/β-D-GalNAc terminal sugars play a significant role during the prenatal spinal cord development.

  11. Divergence of fine and gross motor skills in prelingually deaf children: implications for cochlear implantation.

    Science.gov (United States)

    Horn, David L; Pisoni, David B; Miyamoto, Richard T

    2006-08-01

    The objective of this study was to assess relations between fine and gross motor development and spoken language processing skills in pediatric cochlear implant users. The authors conducted a retrospective analysis of longitudinal data. Prelingually deaf children who received a cochlear implant before age 5 and had no known developmental delay or cognitive impairment were included in the study. Fine and gross motor development were assessed before implantation using the Vineland Adaptive Behavioral Scales, a standardized parental report of adaptive behavior. Fine and gross motor scores reflected a given child's motor functioning with respect to a normative sample of typically developing, normal-hearing children. Relations between these preimplant scores and postimplant spoken language outcomes were assessed. In general, gross motor scores were found to be positively related to chronologic age, whereas the opposite trend was observed for fine motor scores. Fine motor scores were more strongly correlated with postimplant expressive and receptive language scores than gross motor scores. Our findings suggest a disassociation between fine and gross motor development in prelingually deaf children: fine motor skills, in contrast to gross motor skills, tend to be delayed as the prelingually deaf children get older. These findings provide new knowledge about the links between motor and spoken language development and suggest that auditory deprivation may lead to atypical development of certain motor and language skills that share common cortical processing resources.

  12. Motor Importance of motor assessment in school children: analysis of the reliability of the motor development scale doi: 10.5007/1980-0037.2010v12n6p422

    Directory of Open Access Journals (Sweden)

    Francisco Rosa Neto

    2010-09-01

    Full Text Available The objective of this study was to investigate the motor performance of school chil-dren aged 6 to 10 years without learning difficulties (n=101, and to analyze the reliability of the Motor Development Scale (MDS (Rosa Neto, 2002. Descriptive statistics with calculation of the mean, standard deviation, and range was used for data analysis. The internal consistency of the MDS was assessed using Cronbach’s alpha coefficient, and the correlation between variables was determined by Pearson’s linear correlation, with p<0.05. The results showed (1 that motor development was within normal limits in 96% of the children, and (2 a high correlation betwe-en chronological age and general motor age, indicating good internal consistency. These data demonstrate the logic and structured design of the MDS, confirming its reliability.

  13. Piano training in youths with hand motor impairments after damage to the developing brain

    Science.gov (United States)

    Lampe, Renée; Thienel, Anna; Mitternacht, Jürgen; Blumenstein, Tobias; Turova, Varvara; Alves-Pinto, Ana

    2015-01-01

    Damage to the developing brain may lead to impairment of the hand motor function and negatively impact on patients’ quality of life. Development of manual dexterity and finger and hand motor function may be promoted by learning to play the piano. The latter brings together music with the intensive training of hand coordination and fine finger mobility. We investigated if learning to play the piano helped to improve hand motor skills in 18 youths with hand motor disorders resulting from damage during early brain development. Participants trained 35–40 minutes twice a week for 18 months with a professional piano teacher. With the use of a Musical Instrument Digital Interface piano, the uniformity of finger strokes could be objectively assessed from the timing of keystrokes. The analysis showed a significant improvement in the uniformity of keystrokes during the training. Furthermore, the youths showed strong motivation and engagement during the study. This is nevertheless an open study, and further studies remain needed to exclude effects of growth and concomitant therapies on the improvements observed and clarify which patients will more likely benefit from learning to play the piano. PMID:26345312

  14. Spontaneous movements of preterm infants is associated with outcome of gross motor development.

    Science.gov (United States)

    Miyagishima, Saori; Asaka, Tadayoshi; Kamatsuka, Kaori; Kozuka, Naoki; Kobayashi, Masaki; Igarashi, Lisa; Hori, Tsukasa; Tsutsumi, Hiroyuki

    2018-04-30

    We conducted a longitudinal cohort study to analyze the relationship between outcome of gross motor development in preterm infants and factors that might affect their development. Preterm infants with a birth weight of antigravity limbs movements by 3D motion capture system at 3 months corrected age. Gross motor developmental outcomes at 6 and 12 months corrected age were evaluated using the Alberta Infant Motor Scale (AIMS). Statistical analysis was carried out by canonical correlation analysis. Eighteen preterm infants were included. In the 6 months corrected age analysis, spontaneous movement had a major effect on Prone and Sitting at 6 months corrected age of AIMS. In the 12 months corrected age analysis, spontaneous movement had a major effect on Sitting and Standing at 12 months corrected age of AIMS. In preterm infants, better antigravity spontaneous movements at 3 months corrected age were significantly correlated with better gross motor development at 6 or 12 months corrected age. Copyright © 2018 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.

  15. Gross Motor Development in Children Aged 3-5 Years, United States 2012.

    Science.gov (United States)

    Kit, Brian K; Akinbami, Lara J; Isfahani, Neda Sarafrazi; Ulrich, Dale A

    2017-07-01

    Objective Gross motor development in early childhood is important in fostering greater interaction with the environment. The purpose of this study is to describe gross motor skills among US children aged 3-5 years using the Test of Gross Motor Development (TGMD-2). Methods We used 2012 NHANES National Youth Fitness Survey (NNYFS) data, which included TGMD-2 scores obtained according to an established protocol. Outcome measures included locomotor and object control raw and age-standardized scores. Means and standard errors were calculated for demographic and weight status with SUDAAN using sample weights to calculate nationally representative estimates, and survey design variables to account for the complex sampling methods. Results The sample included 339 children aged 3-5 years. As expected, locomotor and object control raw scores increased with age. Overall mean standardized scores for locomotor and object control were similar to the mean value previously determined using a normative sample. Girls had a higher mean locomotor, but not mean object control, standardized score than boys (p  0.05). Conclusions In a nationally representative sample of US children aged 3-5 years, TGMD-2 mean locomotor and object control standardized scores were similar to the established mean. These results suggest that standardized gross motor development among young children generally did not differ by demographic or weight status.

  16. Concurrent validity between instruments of assessment of motor development in infants exposed to HIV.

    Science.gov (United States)

    Siegle, Cristhina Bonilha Huster; Dos Santos Cardoso de Sá, Cristina

    2018-02-01

    Exposure to HIV during pregnancy is a risks to development. Exposed child should have assessed its development since birth. Alberta Infant Motor Scale is a tool which assess gross motor skills, with easy application and low cost. Up to now, this scale had not proven its validity for the population exposed to HIV. It's necessary to compare its with a gold standard tool, Bayley scale, which assess gross and fine motor skills, has a high cost and longer application time required. Studies compare results of Alberta with Bayley's total motor score (gross + fine). However, it's also necessary to compare Alberta's result with only Bayley's gross motor result, because it's what both evaluate in common. to verify the concurrent validity of AIMS in infants exposed to HIV; to verify the correlation of AIMS and BSITD III for this population and to compare if these coefficients differ in the central age groups and extremities of the AIMS. 82 infants exposed to HIV evaluated in 1st, 2nd, 3rd, 4th, 8th, 12th, 15th, 16th, 17th and 18th months, with Alberta Infant Motor Scale and Bayley Scale (motor subscale). For analysis of concurrent validity, results of raw scores of the scales were compared with the correlation analysis. First analysis: Alberta's score with Bayley's total (gross + fine) motor score. Second analysis: Alberta's score with Bayley's gross motor score. In the first correlation analysis, results were: r = 0.62 in 1 st month, r = 0.64 in 2nd month, r = 0.08 in 3rd month, r = 0.45 in 4th month; r = 0.62 in 8th month, r = 0.60 in the 12th month. In the second correlation analysis, results were: r = 0.69 in 1 st month; r = 0.58 in 2nd month; r = 0.25 in 3rd month; r = 0.45 in the 4th month; r = 0.77 in 8th month; r = 0.73 in 12th month. Analyzes of the 15th, 16th, 17th and 18th months couldn't be performed because at these ages all the children had already reached the maximum score in the AIMS. Results were

  17. Deliberate play and preparation jointly benefit motor and cognitive development: mediated and moderated effects

    Directory of Open Access Journals (Sweden)

    Caterina ePesce

    2016-03-01

    Full Text Available In light of the interrelation between motor and cognitive development and the predictive value of the former for the latter, the secular decline observed in motor coordination ability as early as preschool urges identification of interventions that may jointly impact motor and cognitive efficiency.The aim of this study was twofold. It (1 explored the outcomes of enriched physical education, centered on deliberate play and cognitively challenging variability of practice, on motor coordination and cognitive processing; (2 examined whether motor coordination outcomes mediate intervention effects on children’s cognition, while controlling for moderation by lifestyle factors as outdoor play habits and weight status. Four hundred and sixty children aged 5-10 years participated in a 6-month group randomized intervention in physical education, with or without playful coordinative and cognitive enrichment. The weight status and spontaneous outdoor play habits of children (parental report of outdoor play were evaluated at baseline. Before and after the intervention, motor developmental level (Movement Assessment Battery for Children was evaluated in all children, who were then assessed either with a test of working memory (Random Number Generation task, or with a test of attention (from the Cognitive Assessment System, CAS.Children assigned to the ‘enriched’ intervention showed more pronounced improvements in all motor coordination assessments (manual dexterity, ball skills, static/dynamic balance. The beneficial effect on ball skills was amplified by the level of spontaneous outdoor play and weight status. Among indices of executive function and attention, only that of inhibition showed a differential effect of intervention type. Moderated mediation showed that the better outcome of the enriched physical education on ball skills mediated the better inhibition outcome, but only when the enrichment intervention was paralleled by a medium

  18. The Development of the Safety Related Valve Class 1E Electrical Motor, the Target and the Results

    International Nuclear Information System (INIS)

    Saban, I.; Grgic, D.; Fancev, T.; Flegar, Lj.; Novosel, N.

    1996-01-01

    The development of the safety related valves class 1E electric motor is described. The design implemented in order to satisfy the 1E requirements, and a way in which related 1E standards are addressed, are shown. The development was realized in three stages. In the first stage eight motorettes were made and the insulation system was tested. In the second stage the motor was produced in accordance with producer's prototype QA program. In the third stage part of the testing of the produced motor was made. The results of the testing, finished until now, show that produced motor, as well as similarly produced motors, is able to perform its safety function in the design bases accident conditions as requested by class 1E requirements. The rest of the testing (LOCA test) can be made on the same or similar motor in the future. (author)

  19. The interrelationships between motor, cognitive, and language development in children with and without intellectual and developmental disabilities

    NARCIS (Netherlands)

    Houwen, Suzanne; Visser, Linda; van der Putten, Annette; Vlaskamp, Carla

    2016-01-01

    It is generally agreed that cognitive and language development are dependent on the emergence of motor skills. As the literature on this issue concerning children with developmental disabilities is scarce, we examined the interrelationships between motor, cognitive, and language development in

  20. Targeting surface nucleolin with a multivalent pseudopeptide delays development of spontaneous melanoma in RET transgenic mice

    International Nuclear Information System (INIS)

    El Khoury, Diala; Courty, José; Hovanessian, Ara G; Prévost-Blondel, Armelle; Destouches, Damien; Lengagne, Renée; Krust, Bernard; Hamma-Kourbali, Yamina; Garcette, Marylène; Niro, Sandra; Kato, Masashi; Briand, Jean-Paul

    2010-01-01

    The importance of cell-surface nucleolin in cancer biology was recently highlighted by studies showing that ligands of nucleolin play critical role in tumorigenesis and angiogenesis. By using a specific antagonist that binds the C-terminal tail of nucleolin, the HB-19 pseudopeptide, we recently reported that HB-19 treatment markedly suppressed the progression of established human breast tumor cell xenografts in the athymic nude mice without apparent toxicity. The in vivo antitumoral action of HB-19 treatment was assessed on the spontaneous development of melanoma in the RET transgenic mouse model. Ten days old RET mice were treated with HB-19 in a prophylactic setting that extended 300 days. In parallel, the molecular basis for the action of HB-19 was investigated on a melanoma cell line (called TIII) derived from a cutaneous nodule of a RET mouse. HB-19 treatment of RET mice caused a significant delay in the onset of cutaneous tumors, several-months delay in the incidence of large tumors, a lower frequency of cutaneous nodules, and a reduction of visceral metastatic nodules while displaying no toxicity to normal tissue. Moreover, microvessel density was significantly reduced in tumors recovered from HB-19 treated mice compared to corresponding controls. Studies on the melanoma-derived tumor cells demonstrated that HB-19 treatment of TIII cells could restore contact inhibition, impair anchorage-independent growth, and reduce their tumorigenic potential in mice. Moreover, HB-19 treatment caused selective down regulation of transcripts coding matrix metalloproteinase 2 and 9, and tumor necrosis factor-α in the TIII cells and in melanoma tumors of RET mice. Although HB-19 treatment failed to prevent the development of spontaneous melanoma in the RET mice, it delayed for several months the onset and frequency of cutaneous tumors, and exerted a significant inhibitory effect on visceral metastasis. Consequently, HB-19 could provide a novel therapeutic agent by itself or

  1. Development of a methodology for analysis of delayed-neutron signals

    International Nuclear Information System (INIS)

    Gross, K.C.; Strain, R.V.; Fryer, R.M.

    1980-02-01

    Experimental and analytical techniques have been developed for analysis and characterization of delayed-neutron (DN) signals that can provide diagnostic information to augment data from cover-gas analyses in the detection and identification of breached elements in an LMFBR. Eleven flow-reduction tests have been run in EBR-II to provide base data support for predicting DN signal characteristics during exposed-fuel operation. Results from the tests demonstrate the feasibility and practicability of response-analysis techniques for determining (a) the transit time, T/sub tr/, for DN emitters traveling from the core to the detector and (b) the isotropic holdup time, T/sub h/, of DN precursors in the fuel element

  2. Larval development of hoplias cf. Lacerdae (Pisces: Erythrinidae and delayed initial feeding effects

    Directory of Open Access Journals (Sweden)

    Rodolfo N. Sirol

    1998-06-01

    Full Text Available Larval development of Hoplias cf. lacerdae was studied under laboratory conditions. After hatching, ontogenetic changes were recorded on food-deprived larvae in 12-hour intervals. Mouth opening occurred after 2.5 days and notochord terminated flexure in 6.5 days. Notochord length increased at a constant rate until complete yolk absorption (13,5 days. Larval dry weight and body height diminished gradually up to 21 days after hatching, when all starved larvae died. Every 12 hours after yolk absorption, groups of larvae (n=15, were separeted, and fed with Artemia nauplii for 10 days. The point-of-no-return (when 50% of larvae were unable to feed or to assimilate ingested food after delayed feeding, was not apparent in this species.

  3. Windows of sensitivity to toxic chemicals in the motor effects development.

    Science.gov (United States)

    Ingber, Susan Z; Pohl, Hana R

    2016-02-01

    Many chemicals currently used are known to elicit nervous system effects. In addition, approximately 2000 new chemicals introduced annually have not yet undergone neurotoxicity testing. This review concentrated on motor development effects associated with exposure to environmental neurotoxicants to help identify critical windows of exposure and begin to assess data needs based on a subset of chemicals thoroughly reviewed by the Agency for Toxic Substances and Disease Registry (ATSDR) in Toxicological Profiles and Addenda. Multiple windows of sensitivity were identified that differed based on the maturity level of the neurological system at the time of exposure, as well as dose and exposure duration. Similar but distinct windows were found for both motor activity (GD 8-17 [rats], GD 12-14 and PND 3-10 [mice]) and motor function performance (insufficient data for rats, GD 12-17 [mice]). Identifying specific windows of sensitivity in animal studies was hampered by study designs oriented towards detection of neurotoxicity that occurred at any time throughout the developmental process. In conclusion, while this investigation identified some critical exposure windows for motor development effects, it demonstrates a need for more acute duration exposure studies based on neurodevelopmental windows, particularly during the exposure periods identified in this review. Published by Elsevier Inc.

  4. Development of an induction motor abnormality monitoring system(IMAMS) using power line signal analysis

    International Nuclear Information System (INIS)

    Jung, Jae Cheon

    1997-02-01

    An induction motor abnormality monitoring system using power line signal analysis is developed in this work. Various studies have focused their attention on the detection of particular harmonic frequencies produced from each defect mode of motors. However, these harmonic frequencies are valuable only when the motor has a continuous slip frequency and operate in constant torque/load condition. The basic concept of the system developed in this work is to detect the characteristic harmonic frequencies occurred when the motor is in abnormal state and to compare it with a predetermined setpoint. Based on these analyses, the place and degree of defect can be easily identified. The experimental results under test bench simulation are also introduced. To find out an alternative way to obtain a threshold level independent of slip/torque, with the rotating field theory, the ratio between harmonic current and total current was calculated with the simplified circuit that is equivalent to two abnormal cases, such as the spatial rotor resistance variation and the symmetrical components changes with field. Also, the threshold level calculation was done with performed the rotating field theory. The results show that they are in good agreement with a experimental results. Further studies are undertaken to extend this work to the on-line monitoring and diagnostic system with a likelihood ratio test method for field application

  5. Ambulatory EEG NeuroMonitor platform for engagement studies of children with development delays

    Science.gov (United States)

    Mahajan, Ruhi; Consul-Pacareu, Sergi; Abusaud, Mohammed; Sahadat, Md N.; Morshed, Bashir I.

    2013-05-01

    Engagement monitoring is crucial in many clinical and therapy applications such as early learning preschool classes for children with developmental delays including autism spectrum disorder (ASD), attention-deficit hyperactivity disorder (ADHD), or cerebral palsy; as it is challenging for the instructors to evaluate the individual responses of these children to determine the effectiveness of the teaching strategies due to the diverse and unique need of each child who might have difficulty in verbal or behavioral communication. This paper presents an ambulatory scalp electroencephalogram (EEG) NeuroMonitor platform to study brain engagement activities in natural settings. The developed platform is miniature (size: 2.2" x 0.8" x 0.36", weight: 41.8 gm with 800 mAh Li-ion battery and 3 snap leads) and low-power (active mode: 32 mA low power mode: under 5mA) with 2 channels (Fp1, Fp2) to record prefrontal cortex activities of the subject in natural settings while concealed within a headband. The signals from the electrodes are amplified with a low-power instrumentation amplifier; notch filtered (fc = 60Hz), then band-passed by a 2nd-order Chebyshev-I low-pass filter cascaded with a 2nd-order low-pass (fc = 125Hz). A PSoC ADC (16-bit, 256 sps) samples this filtered signal, and can either transmit it through a Class-2 Bluetooth transceiver to a remote station for real-time analysis or store it in a microSD card for offline processing. This platform is currently being evaluated to capture data in the classroom settings for engagement monitoring of children, aimed to study the effectiveness of various teaching strategies that will allow the development of personalized classroom curriculum for children with developmental delays.

  6. Prolactin modulates luteal activity in the short-nosed fruit bat, Cynopterus sphinx during delayed embryonic development.

    Science.gov (United States)

    Anuradha; Krishna, Amitabh

    2017-07-01

    The aim of this study was to evaluate the role of prolactin as a modulator of luteal steroidogenesis during the period of delayed embryonic development in Cynopterus sphinx. A marked decline in circulating prolactin levels was noted during the months of November through December coinciding with the period of decreased serum progesterone and delayed embryonic development. The seasonal changes in serum prolactin levels correlated positively with circulating progesterone (P) level, but inversely with circulating melatonin level during first pregnancy showing delayed development in Cynopterus sphinx. The results also showed decreased expression of prolactin receptor-short form (PRL-RS) both in the corpus luteum and in the utero-embryonic unit during the period of delayed embryonic development. Bats treated in vivo with prolactin during the period of delayed development showed significant increase in serum progesterone and estradiol levels together with significant increase in the expression of PRL-RS, luteinizing hormone receptor (LH-R), steroidogenic acute receptor protein (STAR) and 3β-hydroxysteroid dehydrogenase (3β-HSD) in the ovary. Prolactin stimulated ovarian angiogenesis (vascular endothelial growth factor) and cell survival (B-cell lymphoma 2) in vivo. Significant increases in ovarian progesterone production and the expression of prolactin-receptor, LH-R, STAR and 3β-HSD proteins were noted following the exposure of LH or prolactin in vitro during the delayed period. In conclusion, short-day associated increased melatonin level may be responsible for decreased prolactin release during November-December. The decline in prolactin level might play a role in suppressing P and estradiol-17β (E2) estradiol levels thereby causing delayed embryonic development in C. sphinx. Copyright © 2017 Elsevier Inc. All rights reserved.

  7. Development of an education campaign to reduce delays in pre-hospital response to stroke.

    Science.gov (United States)

    Caminiti, Caterina; Schulz, Peter; Marcomini, Barbara; Iezzi, Elisa; Riva, Silvia; Scoditti, Umberto; Zini, Andrea; Malferrari, Giovanni; Zedde, Maria Luisa; Guidetti, Donata; Montanari, Enrico; Baratti, Mario; Denti, Licia

    2017-06-24

    Systematic reviews call for well-designed trials with clearly described intervention components to support the effectiveness of educational campaigns to reduce patient delay in stroke presentation. We herein describe the systematic development process of a campaign aimed to increase stroke awareness and preparedness. Campaign development followed Intervention Mapping (IM), a theory- and evidence-based tool, and was articulated in two phases: needs assessment and intervention development. In phase 1, two cross-sectional surveys were performed, one aiming to measure stroke awareness in the target population and the other to analyze the behavioral determinants of prehospital delay. In phase 2, a matrix of proximal program objectives was developed, theory-based intervention methods and practical strategies were selected and program components and materials produced. In phase 1, the survey on 202 citizens highlighted underestimation of symptom severity, as in only 44% of stroke situations respondents would choose to call the emergency service (EMS). In the survey on 393 consecutive patients, 55% presented over 2 hours after symptom onset; major determinants were deciding to call the general practitioner first and the reaction of the first person the patient called. In phase 2, adult individuals were identified as the target of the intervention, both as potential "patients" and witnesses of stroke. The low educational level found in the patient survey called for a narrative approach in cartoon form. The family setting was chosen for the message because 42% of patients who presented within 2 hours had been advised by a family member to call EMS. To act on people's tendency to view stroke as an untreatable disease, it was decided to avoid fear-arousal appeals and use a positive message providing instructions and hope. Focus groups were used to test educational products and identify the most suitable sites for message dissemination. The IM approach allowed to develop a

  8. Effects of parenting role and parent-child interaction on infant motor development in Taiwan Birth Cohort Study.

    Science.gov (United States)

    Chiang, Yi-Chen; Lin, Dai-Chan; Lee, Chun-Yang; Lee, Meng-Chih

    2015-04-01

    Previous studies have rarely focused on healthy infants' motor development, and nationwide birth cohort studies in Taiwan are limited. It has been shown that parent-child interactions significantly influence infant motor development and the effect of mother-infant attachment on infant development is stronger than father-infant attachment. However, it is not well understood that whether the mother-infant or father-infant interaction has the confounding effect on infant motor development. To understand healthy infant motor development in Taiwan; and to investigate the effects of parenting roles and parent-child interactions on infant motor development. Data were derived from the 1st through the 2nd waves of the Taiwan Birth Cohort Study-Pilot Database. Infants were classified into two categories (complete or incomplete development) according to their developmental milestones. Generalized estimating equations (GEE) and random effects models were used to clarify the possible long-term effects. The rate of infants who completed development in 6 months was 30.50%; however the rate was increased in 18 month-old children (80.01%). A mother's perceived infant care competence was the most important factor for infant motor development. "Whether or not the infant was the only baby in the family" and "parent-child interaction" had slightly significant effect on infant motor development. In conclusion, the mother's perceived competence must be strengthened and parent-infant interactions should be emphasized on a daily basis. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  9. Visual strategies underpinning the development of visual-motor expertise when hitting a ball.

    Science.gov (United States)

    Sarpeshkar, Vishnu; Abernethy, Bruce; Mann, David L

    2017-10-01

    It is well known that skilled batters in fast-ball sports do not align their gaze with the ball throughout ball-flight, but instead adopt a unique sequence of eye and head movements that contribute toward their skill. However, much of what we know about visual-motor behavior in hitting is based on studies that have employed case study designs, and/or used simplified tasks that fall short of replicating the spatiotemporal demands experienced in the natural environment. The aim of this study was to provide a comprehensive examination of the eye and head movement strategies that underpin the development of visual-motor expertise when intercepting a fast-moving target. Eye and head movements were examined in situ for 4 groups of cricket batters, who were crossed for playing level (elite or club) and age (U19 or adult), when hitting balls that followed either straight or curving ('swinging') trajectories. The results provide support for some widely cited markers of expertise in batting, while questioning the legitimacy of others. Swinging trajectories alter the visual-motor behavior of all batters, though in large part because of the uncertainty generated by the possibility of a variation in trajectory rather than any actual change in trajectory per se. Moreover, curving trajectories influence visual-motor behavior in a nonlinear fashion, with targets that curve away from the observer influencing behavior more than those that curve inward. The findings provide a more comprehensive understanding of the development of visual-motor expertise in interception. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  10. Prevalence of motor-skill impairment in preterm children who do not develop cerebral palsy: a systematic review.

    Science.gov (United States)

    Williams, Jacqueline; Lee, Katherine J; Anderson, Peter J

    2010-03-01

    Motor skill impairment is a common negative outcome in children born preterm who do not develop cerebral palsy (CP). This study aimed to conduct a systematic review of current data to provide an accurate estimate of the prevalence of non-CP motor impairment in preterm children at school age. We searched the Medline, PubMed, and PsycInfo databases and relevant journals to identify all studies published post-1990 that reported the prevalence of motor impairment in school-aged children born preterm (children was 40.5/100. and for moderate motor impairment the estimate was 19.0/100. There was also a trend for lower motor impairment levels in samples born before 1990 compared with those born after 1990. Children born preterm are at increased risk of motor impairment, with prevalence three to four times greater than in the general population. This highlights the need for improved surveillance and intervention strategies in this group of children.

  11. Development of a new esomeprazole delayed release gastro-resistant pellet formulation with improved storage stability.

    Science.gov (United States)

    Barmpalexis, Panagiotis; Grypioti, Agni

    2018-06-01

    This study describes the development of a new esomeprazole (ESO) delayed release gastro-resistant formulation with improved storage stability. A three-step (drug-, sub(seal)- and enteric-) coating process was employed with the aid of a fluid bed coater. Several formulation factors (namely, size and quantity of starting non-pareil sugar spheres, binder quantity during drug-layering, sub(seal)-coating polymer type, and quantity and enteric coating quantity) were evaluated and the whole process was modeled with the aid of feed-forward back-propagation artificial neural networks (ANNs). Results showed that the selection of small-sized starting spheres (45/60 mesh size) leads to pellet agglomeration, while as sub(seal)-coating weight gain increases a reduction in ESO dissolution rate is observed. The enteric-coating applied (Eudragit L30D-55) showed good gastro-resistant performance in both 0.1 N HCl and pH 4.5 media, while immediate release profiles with more than 85% of ESO being released in less than 30 min were obtained. The effect of cellulose-based sub(seal)-coating polymers, (namely, hydroxypropyl cellulose and hydroxypropylmethyl cellulose) on formulation's storage stability at 40 ± 2 °C/75 ± 5%RH indicated that only hydroxypropylmethyl cellulose was able to stabilize ESO delayed-release formulations in terms of assay, dissolution, impurities, and gastro-resistance performance. Finally, scanning electron microscopy (SEM) analysis revealed smooth and homogeneous external surface/coating layers in all three levels (drug-, sub(seal)-, and enteric- coating), while x-ray diffraction showed no polymorphic transformations.

  12. Increased risk of schizophrenia from additive interaction between infant motor developmental delay and obstetric complications: evidence from a population-based longitudinal study.

    LENUS (Irish Health Repository)

    Clarke, Mary C

    2011-12-01

    Obstetric complications and developmental delay are well-established risk factors for schizophrenia. The authors investigated whether these risk factors interact in an additive manner to further increase risk for schizophrenia.

  13. Developing particulate thin filter using coconut fiber for motor vehicle emission

    Science.gov (United States)

    Wardoyo, A. Y. P.; Juswono, U. P.; Riyanto, S.

    2016-03-01

    Amounts of motor vehicles in Indonesia have been recognized a sharply increase from year to year with the increment reaching to 22 % per annum. Meanwhile motor vehicles produce particulate emissions in different sizes with high concentrations depending on type of vehicles, fuels, and engine capacity. Motor Particle emissions are not only to significantly contribute the atmosphric particles but also adverse to human health. In order to reduce the particle emission, it is needed a filter. This study was aimed to develop a thin filter using coconut fiber to reduce particulate emissions for motor vehicles. The filter was made of coconut fibers that were grinded into power and mixed with glues. The filter was tested by the measurements of particle concentrations coming out from the vehicle exhaust directly and the particle concentrations after passing through the filter. The efficiency of the filter was calculated by ratio of the particle concentrations before comming in the filter to the particle conentrations after passing through the filter. The results showed that the efficiency of the filter obtained more than 30 %. The efficiency increases sharply when a number of the filters are arranged paralelly.

  14. Focal Stroke in the Developing Rat Motor Cortex Induces Age- and Experience-Dependent Maladaptive Plasticity of Corticospinal System.

    Science.gov (United States)

    Gennaro, Mariangela; Mattiello, Alessandro; Mazziotti, Raffaele; Antonelli, Camilla; Gherardini, Lisa; Guzzetta, Andrea; Berardi, Nicoletta; Cioni, Giovanni; Pizzorusso, Tommaso

    2017-01-01

    Motor system development is characterized by an activity-dependent competition between ipsilateral and contralateral corticospinal tracts (CST). Clinical evidence suggests that age is crucial for developmental stroke outcome, with early lesions inducing a "maladaptive" strengthening of ipsilateral projections from the healthy hemisphere and worse motor impairment. Here, we investigated in developing rats the relation between lesion timing, motor outcome and CST remodeling pattern. We induced a focal ischemia into forelimb motor cortex (fM1) at two distinct pre-weaning ages: P14 and P21. We compared long-term motor outcome with changes in axonal sprouting of contralesional CST at red nucleus and spinal cord level using anterograde tracing. We found that P14 stroke caused a more severe long-term motor impairment than at P21, and induced a strong and aberrant contralesional CST sprouting onto denervated spinal cord and red nucleus. The mistargeted sprouting of CST, and the worse motor outcome of the P14 stroke rats were reversed by an early skilled motor training, underscoring the potential of early activity-dependent plasticity in modulating lesion outcome. Thus, changes in the mechanisms controlling CST plasticity occurring during the third postnatal week are associated with age-dependent regulation of the motor outcome after stroke.

  15. Development of a non-delay-line constant-fraction discriminator

    International Nuclear Information System (INIS)

    Yang Tao; Zhao Bo; Zhang Chi

    2002-01-01

    A Non-Delay-Line Constant-Fraction Discriminator (CFD) timing circuit is introduced. The delay line in the CFD is replaced with a low pass filter in this simplified circuit. The timing resolution of the CFD is better than 150 ps

  16. ALK1 heterozygosity delays development of late normal tissue damage in the irradiated mouse kidney

    International Nuclear Information System (INIS)

    Scharpfenecker, Marion; Floot, Ben; Korlaar, Regina; Russell, Nicola S.; Stewart, Fiona A.

    2011-01-01

    Background and Purpose: Activin receptor-like kinase 1 (ALK1) is a transforming growth factor β (TGF-β) receptor, which is mainly expressed in endothelial cells regulating proliferation and migration in vitro and angiogenesis in vivo. Endothelial cells also express the co-receptor endoglin, which modulates ALK1 effects on endothelial cells. Our previous studies showed that mice with reduced endoglin levels develop less irradiation-induced vascular damage and fibrosis, caused by an impaired inflammatory response. This study was aimed at investigating the role of ALK1 in late radiation toxicity. Material and Methods: Kidneys of ALK +/+ and ALK1 +/- mice were irradiated with 14 Gy. Mice were sacrificed at 10, 20, and 30 weeks after irradiation and gene expression and protein levels were analyzed. Results: Compared to wild type littermates, ALK1 +/- mice developed less inflammation and fibrosis at 20 weeks after irradiation, but displayed an increase in pro-inflammatory and pro-fibrotic gene expression at 30 weeks. In addition, ALK1 +/- mice showed superior vascular integrity at 10 and 20 weeks after irradiation which deteriorated at 30 weeks coinciding with changes in the VEGF pathway. Conclusions: ALK1 +/- mice develop a delayed normal tissue response by modulating the inflammatory response and growth factor expression after irradiation.

  17. Blocked, delayed, or obstructed: What causes poor white matter development in intrauterine growth restricted infants?

    Science.gov (United States)

    Tolcos, Mary; Petratos, Steven; Hirst, Jonathan J; Wong, Flora; Spencer, Sarah J; Azhan, Aminath; Emery, Ben; Walker, David W

    2017-07-01

    Poor white matter development in intrauterine growth restricted (IUGR) babies remains a major, untreated problem in neonatology. New therapies, guided by an understanding of the mechanisms that underlie normal and abnormal oligodendrocyte development and myelin formation, are required. Much of our knowledge of the mechanisms that underlie impaired myelination come from studies in adult demyelinating disease, preterm brain injury, or experimental models of hypoxia-ischemia. However, relatively less is known for IUGR which is surprising because IUGR is a leading cause of perinatal mortality and morbidity, second only to premature birth. IUGR is also a significant risk factor for the later development of cerebral palsy, and is a greater risk compared to some of the more traditionally researched antecedents - asphyxia and inflammation. Recent evidence suggests that the white matter injury and reduced myelination in the brains of some preterm babies is due to impaired maturation of oligodendrocytes thereby resulting in the reduced capacity to synthesize myelin. Therefore, it is not surprising that the hypomyelination observable in the central nervous system of IUGR infants has similarly lead to investigations identifying a delay or blockade in the progress of maturation of oligodendrocytes in these infants. This review will discuss current ideas thought to account for the poor myelination often present in the neonate's brain following IUGR, and discuss novel interventions that are promising as treatments that promote oligodendrocyte maturation, and thereby repair the myelination deficits that otherwise persist into infancy and childhood and lead to neurodevelopmental abnormalities. Copyright © 2017 Elsevier Ltd. All rights reserved.

  18. Fine motor control

    Science.gov (United States)

    ... gross (large, general) motor control. An example of gross motor control is waving an arm in greeting. Problems ... out the child's developmental age. Children develop fine motor skills over time, by practicing and being taught. To ...

  19. Nature Elements and Fundamental Motor Skill Development Opportunities at Five Elementary School Districts in British Columbia.

    Science.gov (United States)

    Lim, Christopher; Donovan, Andrew M; Harper, Nevin J; Naylor, Patti-Jean

    2017-10-24

    The majority of Canadian children are not physically active enough for healthy development. School playgrounds are a primary location to promote physical activity and motor skill practice. The benefits of children's play in nature have also been highlighted, but few studies have evaluated children's access and exposure to nature for play on school grounds. This study examined children's access to nature on school grounds and the opportunities afforded by those natural elements for motor skill practice. Extensive naturescapes (multiple nature elements in one setting) were not common, and natural elements were limited, ranging from 1.97 to 5.71 elements/school. The most common element was a forested area (26.5% of all natural elements identified). In comparison to built structures, the number of natural elements was low. Some elements differed between school districts and appeared to be related to local geography and terrain (hilly, rocky terrain, tidal flats, etc.). Our assessment showed that naturescape elements afforded opportunities for the development of some key fundamental motor skills (FMS), specifically, locomotor and stability skills, but opportunities to develop manipulative skills were limited. To maximize potential FMS development, physical literacy, and psycho-social benefits, additional elements or more comprehensive multi-element naturescapes and facilitation (social or environmental) are recommended.

  20. Development of motor imagery and anticipatory action planning in children with developmental coordination disorder: A longitudinal approach

    NARCIS (Netherlands)

    Adams, I.L.J.; Lust, J.M.; Wilson, P.H.; Steenbergen, B.

    2017-01-01

    Children with impaired motor coordination (or Development Coordination Disorder - DCD) have difficulty with the predictive control of movements, evidenced by cross-sectional studies that show impaired motor imagery and action planning abilities. What remains unclear is whether this deficit in

  1. Implications of a neural network model of early sensori-motor development for the field of developmental neurology

    NARCIS (Netherlands)

    van Heijst, JJ; Touwen, BCL; Vos, JE

    This paper reports on a neural network model for early sensori-motor development and on the possible implications of this research for our understanding and, eventually, treatment of motor disorders like cerebral palsy. We recapitulate the results we published in detail in a series of papers [1-4].

  2. DIFFERENCES BETWEEN PUPILS FROM URBAN AND RURAL AREAS IN MORPHOLOGICAL AND MOTORIC DEVELOPMENT

    Directory of Open Access Journals (Sweden)

    Mamaj Driton

    2015-05-01

    Full Text Available One of the most important preconditions for effective influence of physical body exercises among pupils during regular classes of physical education in schools is increased volume and quality of work and study. In order to increase volume and quality of work and study, it is necessary to carry out reform of education at elementary and lower level secondary education in Kosova in order to advance professional personnel and increase number of hours for sport and health education classes. Methods: This research is of a transversal nature, meaning that there has been a measurement of morphological and motoric indicators in the sample of 26 pupils of the age group of 15 years of the elementary and lower level school “Faik Konica” from Prishtina as an urbane center and sample of 30 pupils of elementary and lower level school „Avdulla Tahiri“ from Malisheva. 6 anthropometric and 4 motoric variables have been used (Kurelić et al., 1975. Anthropometric variables included: body height (ATV, length of foot (ADS, body mass (ATT, volume of upper arm in down position (AONL, volume of upper leg (AONK, volume of lower leg (AOPK. Motoric variables included: standing position distance jump (MFESDM, 30 meters distance running (MTR30V, bench bending (MFLPRK, and push-ups (MSKLEK. T-test analysis has been used for independent variables. Results: Obtained results from the statistical analysis demonstrate that anthropometric characteristics and motoric skills of two independent groups of pupils have normal distribution and no visible asymmetry and have tendency toward higher values (epikurtic. T-test analysis demonstrates that pupils from rural areas have lower muscular mass and lower motoric results. Discussion: Conditions for execution of physical education classes and lack of physical activities in the rural environment have strong influence on developments of morphological and motoric characteristics of pupils. Significant statistical differences obtained

  3. Effects of metal exposure on motor neuron development, neuromasts and the escape response of zebrafish embryos.

    Science.gov (United States)

    Sonnack, Laura; Kampe, Sebastian; Muth-Köhne, Elke; Erdinger, Lothar; Henny, Nicole; Hollert, Henner; Schäfers, Christoph; Fenske, Martina

    2015-01-01

    Low level metal contaminations are a prevalent issue with often unknown consequences for health and the environment. Effect-based, multifactorial test systems with zebrafish embryos to assess in particular developmental toxicity are beneficial but rarely used in this context. We therefore exposed wild-type embryos to the metals copper (CuSO4), cadmium (CdCl2) and cobalt (CoSO4) for 72 h to determine lethal as well as sublethal morphological effects. Motor neuron damage was investigated by immunofluorescence staining of primary motor neurons (PMNs) and secondary motor neurons (SMNs). In vivo stainings using the vital dye DASPEI were used to quantify neuromast development and damage. The consequences of metal toxicity were also assessed functionally, by testing fish behavior following tactile stimulation. The median effective concentration (EC50) values for morphological effects 72 h post fertilization (hpf) were 14.6 mg/L for cadmium and 0.018 mg/L for copper, whereas embryos exposed up to 45.8 mg/L cobalt showed no morphological effects. All three metals caused a concentration-dependent reduction in the numbers of normal PMNs and SMNs, and in the fluorescence intensity of neuromasts. The results for motor neuron damage and behavior were coincident for all three metals. Even the lowest metal concentrations (cadmium 2mg/L, copper 0.01 mg/L and cobalt 0.8 mg/L) resulted in neuromast damage. The results demonstrate that the neuromast cells were more sensitive to metal exposure than morphological traits or the response to tactile stimulation and motor neuron damage. Copyright © 2015 Elsevier Inc. All rights reserved.

  4. Prostaglandin-mediated recovery from bacteremia delays larval development in fall armyworm, Spodoptera frugiperda.

    Science.gov (United States)

    Zhang, Lei; Ringbauer, Joseph A; Goodman, Cynthia L; Reall, Tamra; Jiang, Xing-Fu; Stanley, David

    2018-04-01

    Insect immunity includes a surveillance system that detects and signals infections, coupled with hemocytic and humoral immune functions. These functions are signaled and coordinated by several biochemicals, including biogenic amines, insect cytokines, peptides, and prostaglandins (PGs). The actions of these mediators are coordinated within cells by various forms of cross-talk among the signaling systems and they result in effective reactions to infection. While this is well understood, we lack information on how immune-mediated recovery influences subsequent juvenile development in surviving insects. We investigated this point by posing the hypothesis that PG signaling is necessary for larval recovery, although the recovery imposes biological costs, registered in developmental delays and failures in surviving individuals. Here, we report that nodulation responses to infections by the bacterium, Serratia marcescens, increased over time up to 5 h postinfection, with no further nodulation; it increased in a linear manner with increasing bacterial dosages. Larval survivorship decreased with increasing bacterial doses. Treating larvae with the PG-biosynthesis inhibitor, indomethacin, led to sharply decreased nodulation reactions to infection, which were rescued in larvae cotreated with indomethacin and the PG-precursor, arachidonic acid. Although nodulation was fully rescued, all bacterial challenged larvae suffered reduced survivorship compared to controls. Bacterial infection led to reduced developmental rates in larvae, but not pupae. Adult emergence from pupae that developed from experimental larvae was also decreased. Taken together, our data potently bolster our hypothesis. © 2018 Wiley Periodicals, Inc.

  5. Anoxia Treatment for Delaying Skin Browning, Inhibiting Disease Development and Maintaining the Quality of Litchi Fruit

    Directory of Open Access Journals (Sweden)

    Yueming Jiang

    2004-01-01

    Full Text Available Litchi fruit has a very short shelf life after harvest, so marketers and consumers alike desire longer periods of storage, transportation and distribution. To extend shelf life, anoxia treatments were used for the fruit. Litchi fruit were exposed to pure N2 for 0, 3, 6, 12 or 24 h. They were then kept individually in closed but vented containers for 6 days in the dark at 20 °C and 95–100 % relative humidity. Exposure of litchi fruit to N2 for 3 or 6 h markedly delayed skin browning, reduced rot development and maintained higher concentrations of total soluble solids, titratable acidity and ascorbic acid after 6 days of storage. Anoxia treatment for 24 h reduced browning index, but it accelerated disease development, compared to the control. Thus, a pre-storage pure N2 treatment for 3 or 6 h can be an effective means of reducing rotting while maintaining the physical quality of the fruit.

  6. Are cognitive "insomnia" processes involved in the development and maintenance of delayed sleep wake phase disorder?

    Science.gov (United States)

    Richardson, Cele E; Gradisar, Michael; Barbero, Sebastian C

    2016-04-01

    Although individuals with delayed sleep wake phase disorder (DSWPD) and chronic insomnia disorder (CID) share many of the same phenomenological experiences, theories relating to the development and maintenance of these disorders are distinct in focus. Unlike CID, theory relating to DSWPD is primarily physiologically based and assumes almost no cognitive pathway. However, recent research findings suggest that individuals with DSWPD also display many of the sleep-disordered cognitive processes that were previously assumed to be unique to the insomnia experience. As such, this review aims to summarise current research findings to address the question "Could cognitive processes be involved in the development and maintenance of DSWPD?" In particular, the presence of cognitive and physiological pre-sleep arousal, sleep-related attentional bias, distorted perception of sleep and daytime functioning, dysfunctional beliefs and safety behaviours will be investigated. As this emerging area of research requires a stronger evidence base, we highlight suggestions for future investigation and provide preliminary practice points for clinicians assessing and treating "insomnia" in patients with DSWPD. Copyright © 2015 Elsevier Ltd. All rights reserved.

  7. Effect of Tactile-Kinesthetic Stimulation on Motor Development of Low Birth Weight Neonates

    Directory of Open Access Journals (Sweden)

    Reihaneh Askary Kachoosangy

    2011-04-01

    Full Text Available Objectives: Low Birth Weight neonates need complementary interventions (e.g. tactile kinesthetic stimulation to promote their development. This study was conducted to determine the effect of Tactile- Kinesthetic Stimulation (TKS on motor development of Low Birth Weight neonates. Methods: In this clinical trial study, sample was made out of 40 inborn LBW neonates who were divided into two groups randomly. TKS was provided for three 15-minute periods per day for 10 consecutive days to the test group, with the massages consisting of moderate of pressure strokes in prone position and kinesthetic exercises consisting of flexion and extension of limbs in supine position. All measurements were taken before and after completion of the study with the same equipment and by the same person. Results: Results indicated that motor behavior in the intervention group was significantly higher than the control group after the 10 days TKS (P-Value≤0.0001. Discussion: TKS could be an effective intervention in development of motor behavior of LBW neonates. Because very little is known about neonate's behavior, it seems to need more studies in other aspects of behavior in LBW neonates.

  8. Desenvolvimento motor de crianças prematuras e a termo: uso da Alberta Infant Motor Scale Desarrollo motor de niños prematuros y a término: uso de la Alberta Infant Motor Scale Motor development of preterm and term infants: using the Alberta Infant Motor Scale

    Directory of Open Access Journals (Sweden)

    Polyana Candeia Maia

    2011-01-01

    Full Text Available OBJETIVOS: Comparar o desenvolvimento motor de crianças nascidas pré-termo e a termo aos quatro e seis meses de idade, aplicando a Alberta Infant Motor Scale-AIMS na versão brasileira. MÉTODOS: Estudo longitudinal, comparativo, realizado em Fortaleza-Ceará, entre novembro/ 2009 e maio/2010. amostragem por conveniência, foi constituída por 24 crianças pré-termo e 24 a termo. RESULTADOS: Nas crianças de quatro meses, verificou-se diferença estatisticamente significante na posição em pé (p=0,014 e, nas de seis meses, em todas as posições (prono, supina, sentada, em pé e escores totais. Quanto ao percentil, aos quatro e seis meses, respectivamente, 37,5% das crianças pré-termo mostraram desempenho excelente e 54,2%, normais. CONCLUSÃO: A análise estatística do desempenho motor grosso entre os grupos de crianças estudadas mostrou diferenças no desenvolvimento e evolução dos percentis da AIMS.OBJETIVOS: Comparar el desarrollo motor de niños nacidos pretérmino y a término a los cuatro y seis meses de edad, aplicando la Alberta Infant Motor Scale-AIMS en la versión brasileña. MÉTODOS: Estudio longitudinal, comparativo, realizado en Fortaleza-Ceará, entre noviembre/2009 y mayo/2010. La muestra por conveniencia, estuvo constituída por 24 niños pretérmino y 24 a término. RESULTADOS: En los niños de cuatro meses, se verificó una diferencia estadísticamente significativa en la posición podálica (p=0,014 y, en las de seis meses, en todas las posiciones (prona, supina, sentada, podálica y scores totales. En cuanto al percentil, a los cuatro y seis meses, respectivamente, el 37,5% de los niños pretérmino mostraron desempeño excelente y el 54,2%, normales. CONCLUSIÓN: El análisis estadístico del desempeño motor grueso entre los grupos de niños estudiados mostró diferencias en el desarrollo y evolución de los percentiles de la AIMS.OBJECTIVES: To compare the motor development of infants born preterm and term at

  9. The relationship between motor skills and cognitive skills in 4-16 year old typically developing children: A systematic review.

    Science.gov (United States)

    van der Fels, Irene M J; Te Wierike, Sanne C M; Hartman, Esther; Elferink-Gemser, Marije T; Smith, Joanne; Visscher, Chris

    2015-11-01

    This review aims to give an overview of studies providing evidence for a relationship between motor and cognitive skills in typically developing children. A systematic review. PubMed, Web of Science, and PsychINFO were searched for relevant articles. A total of 21 articles were included in this study. Methodological quality was independently assessed by two reviewers. Motor and cognitive skills were divided into six categories. There was either no correlation in the literature, or insufficient evidence for or against many correlations between motor skills and cognitive skills. However, weak-to-strong evidence was found for some correlations between underlying categories of motor and cognitive skills, including complex motor skills and higher order cognitive skills. Furthermore, a stronger relationship between underlying categories of motor and cognitive skills was found in pre-pubertal children compared to pubertal children (older than 13 years). Weak-to-strong relations were found between some motor and cognitive skills. The results suggest that complex motor intervention programs can be used to stimulate both motor and higher order cognitive skills in pre-pubertal children. Copyright © 2014 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.

  10. Development of an acoustic steam generator leak detection system using delay-and-sum beamformer

    International Nuclear Information System (INIS)

    Chikazawa, Yoshitaka

    2009-01-01

    A new acoustic steam generator leak detection system using delay-and-sum beamformer is proposed. The major advantage of the delay-and-sum beamformer is it could provide information of acoustic source direction. An acoustic source of a sodium-water reaction is supposed to be localized while the background noise of the steam generator operation is uniformly distributed in the steam generator tube region. Therefore the delay-and-sum beamformer could distinguish the acoustic source of the sodium-water reaction from steam generator background noise. In this paper, results from numerical analyses are provided to show fundamental feasibility of the new method. (author)

  11. Piano training in youths with hand motor impairments after damage to the developing brain

    Directory of Open Access Journals (Sweden)

    Lampe R

    2015-08-01

    Full Text Available Renée Lampe,1,* Anna Thienel,2 Jürgen Mitternacht,1 Tobias Blumenstein,1 Varvara Turova,1 Ana Alves-Pinto1,* 1Research Unit for Paediatric Neuroorthopaedics and Cerebral Palsy, Orthopaedics Department, Klinikum Rechts der Isar, Technische Universität München, 2Department Sonderpädagogik, Ludwig Maximilians-Universität München, Munich, Germany *These authors contributed equally to this work Abstract: Damage to the developing brain may lead to impairment of the hand motor function and negatively impact on patients’ quality of life. Development of manual dexterity and finger and hand motor function may be promoted by learning to play the piano. The latter brings together music with the intensive training of hand coordination and fine finger mobility. We investigated if learning to play the piano helped to improve hand motor skills in 18 youths with hand motor disorders resulting from damage during early brain development. Participants trained 35–40 minutes twice a week for 18 months with a professional piano teacher. With the use of a Musical Instrument Digital Interface piano, the uniformity of finger strokes could be objectively assessed from the timing of keystrokes. The analysis showed a significant improvement in the uniformity of keystrokes during the training. Furthermore, the youths showed strong motivation and engagement during the study. This is nevertheless an open study, and further studies remain needed to exclude effects of growth and concomitant therapies on the improvements observed and clarify which patients will more likely benefit from learning to play the piano. Keywords: manual skill, cerebral palsy, neurodevelopmental disorder, music, rehabilitation

  12. Site Development and Teaching of Motor Skills in Early Childhood Education

    Directory of Open Access Journals (Sweden)

    Pedro Gil Madrona

    2014-11-01

    Full Text Available In the stage of Early Childhood Education children continue a progressive discovery of their body itself as a source of feelings and sensations, exploring the different possibilities of action and body functions, will constitute the necessary experiences upon which children’s thought is being built. Besides, affective relationships established in situations of psychomotor education, and particularly through game, will be essential for children’s emotional development. In this sense, this article is focused on justifying the necessary presence of Psychomotor education in Early Childhood Education as well as on showing a pedagogical proposal based on an attractive and entertaining motor intervention for children at this stage. This article contains concepts and assumptions about the psychomotor development, movement contents, motor game and the methodological approach where psychomotor storytelling, learning corners, workshops and projects based on action and adventure spaces shine in their own right. Moreover, a didactic design based on programming motor skills at this stage of Early Childhood Education in a funny and lively way also plays a relevant role in this article. We argue that professionals working in the field of Early Childhood psychomotor skills may know and recognize the value of the proposals shown here so that they can teach us to be more critical regarding our professional practice, increasing our concern about the development of motor skills – physical education in Early Childhood Education in its systematic form – which without any doubt will result in children’s higher levels of welfare and health with regards to their own construction of the reality which surrounds them.

  13. Tractography of the corticospinal tracts in infants with focal perinatal injury: comparison with normal controls and to motor development

    International Nuclear Information System (INIS)

    Roze, Elise; Harris, Polly A.; Ball, Gareth; Braga, Rodrigo M.; Allsop, Joanna M.; Counsell, Serena J.; Elorza, Leire Zubiaurre; Merchant, Nazakat; Arichi, Tomoki; Edwards, A.D.; Cowan, Frances M.; Porter, Emma; Rutherford, Mary A.

    2012-01-01

    Our aims were to (1) assess the corticospinal tracts (CSTs) in infants with focal injury and healthy term controls using probabilistic tractography and (2) to correlate the conventional magnetic resonance imaging (MRI) and tractography findings in infants with focal injury with their later motor function. We studied 20 infants with focal lesions and 23 controls using MRI and diffusion tensor imaging. Tract volume, fractional anisotropy (FA), apparent diffusion coefficient (ADC) values, axial diffusivity and radial diffusivity (RD) of the CSTs were determined. Asymmetry indices (AIs) were calculated by comparing ipsilateral to contralateral CSTs. Motor outcome was assessed using a standardized neurological examination. Conventional MRI was able to predict normal motor development (n = 9) or hemiplegia (n = 6). In children who developed a mild motor asymmetry (n = 5), conventional MRI predicted a hemiplegia in two and normal motor development in three infants. The AIs for tract volume, FA, ADC and RD showed a significant difference between controls and infants who developed a hemiplegia, and RD also showed a significant difference in AI between controls and infants who developed a mild asymmetry. Conventional MRI was able to predict subsequent normal motor development or hemiplegia following focal injury in newborn infants. Measures of RD obtained from diffusion tractography may offer additional information for predicting a subsequent asymmetry in motor function. (orig.)

  14. Motor System Development Depends on Experience: A Microgravity Study of Rats

    Science.gov (United States)

    Walton, Kerry D.; Llinas, Rodolfo R.; Kalb, Robert; Hillman, Dean; DeFelipe, Javier; Garcia-Segura, Luis Miguel

    2003-01-01

    Animals move about their environment by sensing their surroundings and making adjustments according to need. All animals take the force of gravity into account when the brain and spinal cord undertake the planning and execution of movements. To what extent must animals learn to factor in the force of gravity when making neural calculations about movement? Are animals born knowing how to respond to gravity, or must the young nervous system learn to enter gravity into the equation? To study this issue, young rats were reared in two different gravitational environments (the one-G of Earth and the microgravity of low Earth orbit) that necessitated two different types of motor operations (movements) for optimal behavior. We inquired whether those portions of the young nervous system involved in movement, the motor system, can adapt to different gravitational levels and, if so, the cellular basis for this phenomenon. We studied two groups of rats that had been raised for 16 days in microgravity (eight or 14 days old at launch) and compared their walking and righting (ability to go from upside down to upright) and brain structure to those of control rats that developed on Earth. Flight rats were easily distinguished from the age-matched ground control rats in terms of both motor function and central nervous system structure. Mature surface righting predominated in control rats on the day of landing (R+O), while immature righting predominated in the flight rats on landing day and 30 days after landing. Some of these changes appear to be permanent. Several conclusions can be drawn from these studies: (1) Many aspects of motor behavior are preprogrammed into the young nervous system. In addition, several aspects of motor behavior are acquired as a function of the interaction of the developing organism and the rearing environment; (2) Widespread neuroanatomical differences between one-G- and microgravity-reared rats indicate that there is a structural basis for the adaptation

  15. A Systematic Review of Barriers to Breast Cancer Care in Developing Countries Resulting in Delayed Patient Presentation

    Directory of Open Access Journals (Sweden)

    Ketan Sharma

    2012-01-01

    Full Text Available Background. Within the developing world, many personal, sociocultural, and economic factors cause delayed patient presentation, a prolonged interval from initial symptom discovery to provider presentation. Understanding these barriers to care is crucial to optimizing interventions that pre-empt patient delay. Methods. A systematic review was conducted querying: PubMed, Embase, Web of Science, CINAHL, Cochrane Library, J East, CAB, African Index Medicus, and LiLACS. Of 763 unique abstracts, 122 were extracted for full review and 13 included in final analysis. Results. Studies posed variable risks of bias and produced mixed results. There is strong evidence that lower education level and lesser income status contribute to patient delay. There is weaker and, sometimes, contradictory evidence that other factors may also contribute. Discussion. Poverty emerges as the underlying common denominator preventing earlier presentation in these settings. The evidence for sociocultural variables is less strong, but may reflect current paucity of high-quality research. Conflicting results may be due to heterogeneity of the developing world itself. Conclusion. Future research is required that includes patients with and without delay, utilizes a validated questionnaire, and controls for potential confounders. Current evidence suggests that interventions should primarily increase proximal and affordable healthcare access and secondarily enhance breast cancer awareness, to productively reduce patient delay.

  16. World-wide developments in motor vehicle inspection/maintenance (I/M) programs

    Energy Technology Data Exchange (ETDEWEB)

    Klausmeier, R. [Consulting Inc., Austin, TX (United States); Kishan, S. [Radian Corporation, Austin, TX (United States)

    1995-12-31

    Motor vehicles contribute much to urban air pollution. As a result, most governments have enacted emission standards that significantly lower pollutant emission levels from new motor vehicles. For example, vehicles built in the United States emit 95 % fewer pollutants than uncontrolled vehicles when they are new. However, studies indicate that proper maintenance is needed to obtain the full benefit of vehicle emission controls. Furthermore, there is evidence that a significant percentage of the vehicle fleet is not properly maintained. This has led to the creation of motor vehicle Inspection/Maintenance (I/M) Programs. I/M programs inspect vehicles for indications that they are emitting excessive quantities of pollutants. Vehicles that fail the inspection must be repaired in order to comply with program requirements. The first I/M programs were implemented in the United States in the early 1970s. With substantial urging from the federal government, most of the U.S. states with severe air pollution problems have implemented I/M programs. Recently, with the passage of the U.S. Clean Air Act Amendments of 1990, many states have been required to significantly upgrade the performance and coverage of their I/M programs. I/M programs also have been implemented in Europe and recently in Asia. This presentation reviews developments in I/M programs for light-duty gasoline powered vehicles. Developments in I/M programs for diesel powered vehicles are briefly described. (author)

  17. Test of Gross Motor Development: expert validity, confirmatory validity and internal consistence

    Directory of Open Access Journals (Sweden)

    Nadia Cristina Valentini

    2008-01-01

    The Test of Gross Motor Development (TGMD-2 is an instrument used to evaluate children’s level of motor development. The objective of this study was to translate and verify the clarity and pertinence of the TGMD-2 items by experts and the confirmatory factorial validity and the internal consistence by means of test-retest of the Portuguese TGMD-2. A cross-cultural translation was used to construct the Portuguese version. The participants of this study were 7 professionals and 587 children, from 27 schools (kindergarten and elementary from 3 to 10 years old (51.1% boys and 48.9% girls. Each child was videotaped performing the test twice. The videotaped tests were then scored. The results indicated that the Portuguese version of the TGMD-2 contains clear and pertinent motor items; demonstrated satisfactory indices of confirmatory factorial validity (÷2/gl = 3.38; Goodness-of-fit Index = 0.95; Adjusted Goodness-of-fit index = 0.92 and Tucker and Lewis’s Index of Fit = 0.83 and test-retest internal consistency (locomotion r = 0.82; control of object: r = 0.88. The Portuguese TGMD-2 demonstrated validity and reliability for the sample investigated.

  18. Development of Erosive Burning Models for CFD Predictions of Solid Rocket Motor Internal Environments

    Science.gov (United States)

    Wang, Qun-Zhen

    2003-01-01

    Four erosive burning models, equations (11) to (14). are developed in this work by using a power law relationship to correlate (1) the erosive burning ratio and the local velocity gradient at propellant surfaces; (2) the erosive burning ratio and the velocity gradient divided by centerline velocity; (3) the erosive burning difference and the local velocity gradient at propellant surfaces; and (4) the erosive burning difference and the velocity gradient divided by centerline velocity. These models depend on the local velocity gradient at the propellant surface (or the velocity gradient divided by centerline velocity) only and, unlike other empirical models, are independent of the motor size. It was argued that, since the erosive burning is a local phenomenon occurring near the surface of the solid propellant, the erosive burning ratio should be independent of the bore diameter if it is correlated with some local flow parameters such as the velocity gradient at the propellant surface. This seems to be true considering the good results obtained by applying these models, which are developed from the small size 5 inch CP tandem motor testing, to CFD simulations of much bigger motors.

  19. World-wide developments in motor vehicle inspection/maintenance (I/M) programs

    Energy Technology Data Exchange (ETDEWEB)

    Klausmeier, R [Consulting Inc., Austin, TX (United States); Kishan, S [Radian Corporation, Austin, TX (United States)

    1996-12-31

    Motor vehicles contribute much to urban air pollution. As a result, most governments have enacted emission standards that significantly lower pollutant emission levels from new motor vehicles. For example, vehicles built in the United States emit 95 % fewer pollutants than uncontrolled vehicles when they are new. However, studies indicate that proper maintenance is needed to obtain the full benefit of vehicle emission controls. Furthermore, there is evidence that a significant percentage of the vehicle fleet is not properly maintained. This has led to the creation of motor vehicle Inspection/Maintenance (I/M) Programs. I/M programs inspect vehicles for indications that they are emitting excessive quantities of pollutants. Vehicles that fail the inspection must be repaired in order to comply with program requirements. The first I/M programs were implemented in the United States in the early 1970s. With substantial urging from the federal government, most of the U.S. states with severe air pollution problems have implemented I/M programs. Recently, with the passage of the U.S. Clean Air Act Amendments of 1990, many states have been required to significantly upgrade the performance and coverage of their I/M programs. I/M programs also have been implemented in Europe and recently in Asia. This presentation reviews developments in I/M programs for light-duty gasoline powered vehicles. Developments in I/M programs for diesel powered vehicles are briefly described. (author)

  20. PROGame: A process framework for serious game development for motor rehabilitation therapy.

    Science.gov (United States)

    Amengual Alcover, Esperança; Jaume-I-Capó, Antoni; Moyà-Alcover, Biel

    2018-01-01

    Serious game development for rehabilitation therapy is becoming increasingly popular because of the motivational advantages that these types of applications provide. Consequently, the need for a common process framework for this category of software development has become increasingly evident. The goal is to guarantee that products are developed and validated by following a coherent and systematic method that leads to high-quality serious games. This paper introduces a new process framework for the development of serious games for motor rehabilitation therapy. We introduce the new model and demonstrate its application for the development of a serious game for the improvement of the balance and postural control of adults with cerebral palsy. The development of this application has been facilitated by two technological transfer contracts and is being exploited by two different organizations. According to clinical measurements, patients using the application improved from high fall risk to moderate fall risk. We believe that our development strategy can be useful not only for motor rehabilitation therapy, but also for the development of serious games in many other rehabilitation areas.

  1. Toddler Developmental Delays After Extensive Hospitalization: Primary Care Practitioner Guidelines.

    Science.gov (United States)

    Lehner, Dana C; Sadler, Lois S

    2015-01-01

    This review investigated developmental delays toddlers may encounter after a lengthy pediatric hospitalization (30 days or greater). Physical, motor, cognitive, and psychosocial development of children aged 1 to 3 years was reviewed to raise awareness of factors associated with developmental delay after extensive hospitalization. Findings from the literature suggest that neonatal and pediatric intensive care unit (NICU/PICU) graduates are most at risk for developmental delays, but even non-critical hospital stays interrupt development to some extent. Primary care practitioners (PCPs) may be able to minimize risk for delays through the use of formal developmental screening tests and parent report surveys. References and resources are described for developmental assessment to help clinicians recognize delays and to educate families about optimal toddler development interventions. Pediatric PCPs play a leading role in coordinating health and developmental services for the young child following an extensive hospital stay.

  2. Enhanced insulin sensitivity in prepubertal children with constitutional delay of growth and development.

    Science.gov (United States)

    Wilson, Dyanne A; Hofman, Paul L; Miles, Harriet L; Sato, Tim A; Billett, Nathalie E; Robinson, Elizabeth M; Cutfield, Wayne S

    2010-02-01

    To test the hypothesis that prepubertal children with presumed constitutional delay of growth and development (CDGD) have enhanced insulin sensitivity and, therefore, insulin sensitivity is associated with later onset of puberty. Twenty-one prepubertal children with presumed CDGD and 23 prepubertal control children, underwent a frequently sampled intravenous glucose tolerance test to evaluate insulin sensitivity and other markers of insulin, glucose, and growth regulation. Children in the CDGD group were shorter and leaner than control subjects. Children with presumed CDGD were 40% more insulin sensitive (17.0 x 10(-4) min(-1)/[mU/L] versus 12.1 x 10(-4) min(-1)/[mU/L]; P = .0006) and had reduced acute insulin response, thus maintaining euglycemia (216 mU/L versus 330 mU/L; P = .02) compared with control subjects. In addition, the CDGD group had lower serum insulin-like growth factor binding protein 3 levels (3333 ng/mL versus 3775 ng/mL; P = .0004) and a trend toward lower serum insulin-like growth factor-II levels (794 ng/mL versus 911 ng/mL; P = .06). Prepubertal children with presumed CDGD have enhanced insulin sensitivity, supporting the hypothesis that insulin sensitivity is associated with timing of puberty. It may signify long-term biological advantages with lower risk of metabolic syndrome and malignancy. Copyright 2010 Mosby, Inc. All rights reserved.

  3. Development and test of an axial flux type PM synchronous motor with liquid nitrogen cooled HTS armature windings

    International Nuclear Information System (INIS)

    Sugimoto, H; Morishita, T; Tsuda, T; Takeda, T; Togawa, H; Oota, T; Ohmatsu, K; Yoshida, S

    2008-01-01

    We developed an axial gap permanent magnet type superconducting synchronous motor cooled by liquid nitrogen (LN 2 ). The motor includes 8 poles and 6 armature windings. The armature windings are made from BSCCO wire operated at the temperature level between 66K∼70K. The design of the rated output is 400kW at 250rpm. Because HTS wires produce AC loss, there are few motors developed with a superconducting armature winding. In a large capacity motor, HTS windings need to be connected in parallel way. However, the parallel connection causes different current flowing to each HTS winding. To solve this problem, we connected a current distributor to the motor. As a result, not only the current difference can be suppressed, but also the current of each winding can be adjusted freely. The low frequency and less flux penetrating HTS wire because of current distributor contribute to low AC loss. This motor is an axial gap rotating-field one, the cooling parts are fixed. This directly leads to simple cooling system. The motor is also brushless. This paper presents the structure, the analysis of the motor and the tests

  4. FIM-Minimum Data Set Motor Item Bank: Short Forms Development and Precision Comparison in Veterans.

    Science.gov (United States)

    Li, Chih-Ying; Romero, Sergio; Simpson, Annie N; Bonilha, Heather S; Simpson, Kit N; Hong, Ickpyo; Velozo, Craig A

    2018-03-01

    To improve the practical use of the short forms (SFs) developed from the item bank, we compared the measurement precision of the 4- and 8-item SFs generated from a motor item bank composed of the FIM and the Minimum Data Set (MDS). The FIM-MDS motor item bank allowed scores generated from different instruments to be co-calibrated. The 4- and 8-item SFs were developed based on Rasch analysis procedures. This article compared person strata, ceiling/floor effects, and test SE plots for each administration form and examined 95% confidence interval error bands of anchored person measures with the corresponding SFs. We used 0.3 SE as a criterion to reflect a reliability level of .90. Veterans' inpatient rehabilitation facilities and community living centers. Veterans (N=2500) who had both FIM and the MDS data within 6 days during 2008 through 2010. Not applicable. Four- and 8-item SFs of FIM, MDS, and FIM-MDS motor item bank. Six SFs were generated with 4 and 8 items across a range of difficulty levels from the FIM-MDS motor item bank. The three 8-item SFs all had higher correlations with the item bank (r=.82-.95), higher person strata, and less test error than the corresponding 4-item SFs (r=.80-.90). The three 4-item SFs did not meet the criteria of SE bank composed of existing instruments across the continuum of care in veterans. We also found that the number of items, not test specificity, determines the precision of the instrument. Copyright © 2017 American Congress of Rehabilitation Medicine. All rights reserved.

  5. Cross-Cultural Differences in Parental Beliefs About Infant Motor Development : A Quantitative and Qualitative Report of Middle-Class Israeli and Dutch Parents

    NARCIS (Netherlands)

    van Schaik, S.D.M.|info:eu-repo/dai/nl/357534689; Oudgenoeg-Paz, O.|info:eu-repo/dai/nl/341157627; Atun-Einy, Osnat

    The present study explored cultural differences in parental beliefs about motor development across 2 Western cultures: Israel and the Netherlands. Can 2 cultural models be distinguished regarding infant motor development in Israel and the Netherlands or are parental beliefs about motor development

  6. The Dutch motor skills assessment as tool for talent development in table tennis: a reproducibility and validity study.

    Science.gov (United States)

    Faber, Irene R; Nijhuis-Van Der Sanden, Maria W G; Elferink-Gemser, Marije T; Oosterveld, Frits G J

    2015-01-01

    A motor skills assessment could be helpful in talent development by estimating essential perceptuo-motor skills of young players, which are considered requisite to develop excellent technical and tactical qualities. The Netherlands Table Tennis Association uses a motor skills assessment in their talent development programme consisting of eight items measuring perceptuo-motor skills specific to table tennis under varying conditions. This study aimed to investigate this assessment regarding its reproducibility, internal consistency, underlying dimensions and concurrent validity in 113 young table tennis players (6-10 years). Intraclass correlation coefficients of six test items met the criteria of 0.7 with coefficients of variation between 3% and 8%. Cronbach's alpha valued 0.853 for internal consistency. The principal components analysis distinguished two conceptually meaningful factors: "ball control" and "gross motor function." Concurrent validity analyses demonstrated moderate associations between the motor skills assessment's results and national ranking; boys r = -0.53 (P motor skills assessment seems to be a reproducible, objective part of a talent development programme, more longitudinal studies are required to investigate its predictive validity.

  7. A Diagnostic Marker to Discriminate Childhood Apraxia of Speech from Speech Delay: I. Development and Description of the Pause Marker

    Science.gov (United States)

    Shriberg, Lawrence D.; Strand, Edythe A.; Fourakis, Marios; Jakielski, Kathy J.; Hall, Sheryl D.; Karlsson, Heather B.; Mabie, Heather L.; McSweeny, Jane L.; Tilkens, Christie M.; Wilson, David L.

    2017-01-01

    Purpose: The goal of this article (PM I) is to describe the rationale for and development of the Pause Marker (PM), a single-sign diagnostic marker proposed to discriminate early or persistent childhood apraxia of speech from speech delay. Method: The authors describe and prioritize 7 criteria with which to evaluate the research and clinical…

  8. Effects of music therapy in the treatment of children with delayed speech development - results of a pilot study.

    Science.gov (United States)

    Gross, Wibke; Linden, Ulrike; Ostermann, Thomas

    2010-07-21

    Language development is one of the most significant processes of early childhood development. Children with delayed speech development are more at risk of acquiring other cognitive, social-emotional, and school-related problems. Music therapy appears to facilitate speech development in children, even within a short period of time. The aim of this pilot study is to explore the effects of music therapy in children with delayed speech development. A total of 18 children aged 3.5 to 6 years with delayed speech development took part in this observational study in which music therapy and no treatment were compared to demonstrate effectiveness. Individual music therapy was provided on an outpatient basis. An ABAB reversal design with alternations between music therapy and no treatment with an interval of approximately eight weeks between the blocks was chosen. Before and after each study period, a speech development test, a non-verbal intelligence test for children, and music therapy assessment scales were used to evaluate the speech development of the children. Compared to the baseline, we found a positive development in the study group after receiving music therapy. Both phonological capacity and the children's understanding of speech increased under treatment, as well as their cognitive structures, action patterns, and level of intelligence. Throughout the study period, developmental age converged with their biological age. Ratings according to the Nordoff-Robbins scales showed clinically significant changes in the children, namely in the areas of client-therapist relationship and communication. This study suggests that music therapy may have a measurable effect on the speech development of children through the treatment's interactions with fundamental aspects of speech development, including the ability to form and maintain relationships and prosodic abilities. Thus, music therapy may provide a basic and supportive therapy for children with delayed speech development

  9. Psychometric properties of the motor diagnostics in the German football talent identification and development programme.

    Science.gov (United States)

    HÖner, Oliver; Votteler, Andreas; Schmid, Markus; Schultz, Florian; Roth, Klaus

    2015-01-01

    The utilisation of motor performance tests for talent identification in youth sports is discussed intensively in talent research. This article examines the reliability, differential stability and validity of the motor diagnostics conducted nationwide by the German football talent identification and development programme and provides reference values for a standardised interpretation of the diagnostics results. Highly selected players (the top 4% of their age groups, U12-U15) took part in the diagnostics at 17 measurement points between spring 2004 and spring 2012 (N = 68,158). The heterogeneous test battery measured speed abilities and football-specific technical skills (sprint, agility, dribbling, ball control, shooting, juggling). For all measurement points, the overall score and the speed tests showed high internal consistency, high test-retest reliability and satisfying differential stability. The diagnostics demonstrated satisfying factorial-related validity with plausible and stable loadings on the two empirical factors "speed" and "technical skills". The score, and the technical skills dribbling and juggling, differentiated the most among players of different performance levels and thus showed the highest criterion-related validity. Satisfactory psychometric properties for the diagnostics are an important prerequisite for a scientifically sound rating of players' actual motor performance and for the future examination of the prognostic validity for success in adulthood.

  10. Development of Model for Pedestrian Gap Based on Land Use Pattern at Midblock Location and Estimation of Delay at Intersections

    Science.gov (United States)

    Ramesh, Adepu; Ashritha, Kilari; Kumar, Molugaram

    2018-04-01

    Walking has always been a prime source of human mobility for short distance travel. Traffic congestion has become a major problem for safe pedestrian crossing in most of the metropolitan cities. This has emphasized for providing a sufficient pedestrian gap for safe crossing on urban road. The present works aims in understanding factors that influence pedestrian crossing behaviour. Four locations were chosen for identification of pedestrian crossing behaviour, gap characteristics, waiting time etc., in Hyderabad city. From the study it was observed that pedestrian behaviour and crossing patterns are different and is influenced by land use pattern. A gap acceptance model was developed from the data for improving pedestrian safety at mid-block location; the model was validated using the existing data. Pedestrian delay was estimated at intersection using Highway Capacity Manual (HCM). It was observed that field delays are less when compared to delay arrived from HCM method.

  11. Development and Characterization of Fast Burning Solid Fuels/Propellants for Hybrid Rocket Motors with High Volumetric Efficiency

    Data.gov (United States)

    National Aeronautics and Space Administration — The objective of this proposed work is to develop several fast burning solid fuels/fuel-rich solid propellants for hybrid rocket motor applications. In the...

  12. The validity of parental reports on motor skills performance level in preschool children: a comparison with a standardized motor test.

    Science.gov (United States)

    Zysset, Annina E; Kakebeeke, Tanja H; Messerli-Bürgy, Nadine; Meyer, Andrea H; Stülb, Kerstin; Leeger-Aschmann, Claudia S; Schmutz, Einat A; Arhab, Amar; Ferrazzini, Valentina; Kriemler, Susi; Munsch, Simone; Puder, Jardena J; Jenni, Oskar G

    2018-05-01

    Motor skills are interrelated with essential domains of childhood such as cognitive and social development. Thus, the evaluation of motor skills and the identification of atypical or delayed motor development is crucial in pediatric practice (e.g., during well-child visits). Parental reports on motor skills may serve as possible indicators to decide whether further assessment of a child is necessary or not. We compared parental reports on fundamental motor skills performance level (e.g., hopping, throwing), based on questions frequently asked in pediatric practice, with a standardized motor test in 389 children (46.5% girls/53.5% boys, M age = 3.8 years, SD = 0.5, range 3.0-5.0 years) from the Swiss Preschoolers' Health Study (SPLASHY). Motor skills were examined using the Zurich Neuromotor Assessment 3-5 (ZNA3-5), and parents filled in an online questionnaire on fundamental motor skills performance level. The results showed that the answers from the parental report correlated only weakly with the objectively assessed motor skills (r = .225, p skills would be desirable, the parent's report used in this study was not a valid indicator for children's fundamental motor skills. Thus, we may recommend to objectively examine motor skills in clinical practice and not to exclusively rely on parental report. What is Known: • Early assessment of motor skills in preschool children is important because motor skills are essential for the engagement in social activities and the development of cognitive abilities. Atypical or delayed motor development can be an indicator for different developmental needs or disorders. • Pediatricians frequently ask parents about the motor competences of their child during well-child visits. What is New: • The parental report on fundamental motor skills performance level used in this study was not a reliable indicator for describing motor development in the preschool age. • Standardized examinations of motor skills are

  13. Longitudinal Theory of Mind (ToM) Development From Preschool to Adolescence With and Without ToM Delay.

    Science.gov (United States)

    Peterson, Candida C; Wellman, Henry M

    2018-04-16

    Longitudinal tracking of 107 three- to-thirteen-year-olds in a cross-sequential design showed a 6-step theory of mind (ToM) sequence identified by a few past cross-sectional studies validly depicted longitudinal ToM development from early to middle childhood for typically developing (TD) children and those with ToM delays owing to deafness or autism. Substantively, all groups showed ToM progress throughout middle childhood. Atypical development was more extended and began and ended at lower levels than for TD children. Yet most children in all groups progressed over the study's mean 1.5 years. Findings help resolve theoretical debates about ToM development for children with and without delay and gain strength and weight via their applicability to three disparate groups varying in ToM timing and sequencing. © 2018 Society for Research in Child Development.

  14. The Development of a Motor-Free Short-Form of the Wechsler Intelligence Scale for Children-Fifth Edition.

    Science.gov (United States)

    Piovesana, Adina M; Harrison, Jessica L; Ducat, Jacob J

    2017-12-01

    This study aimed to develop a motor-free short-form of the Wechsler Intelligence Scale for Children-Fifth Edition (WISC-V) that allows clinicians to estimate the Full Scale Intelligence Quotients of youths with motor impairments. Using the reliabilities and intercorrelations of six WISC-V motor-free subtests, psychometric methodologies were applied to develop look-up tables for four Motor-free Short-form indices: Verbal Comprehension Short-form, Perceptual Reasoning Short-form, Working Memory Short-form, and a Motor-free Intelligence Quotient. Index-level discrepancy tables were developed using the same methods to allow clinicians to statistically compare visual, verbal, and working memory abilities. The short-form indices had excellent reliabilities ( r = .92-.97) comparable to the original WISC-V. This motor-free short-form of the WISC-V is a reliable alternative for the assessment of intellectual functioning in youths with motor impairments. Clinicians are provided with user-friendly look-up tables, index level discrepancy tables, and base rates, displayed similar to those in the WISC-V manuals to enable interpretation of assessment results.

  15. Role of leptin in delayed embryonic development in the Indian short-nosed fruit bat, Cynopterus sphinx.

    Science.gov (United States)

    Banerjee, A; Meenakumari, K J; Krishna, A

    2010-08-01

    An adiposity-associated rise in leptin occurs at the time of delayed embryonic development in Cynopterus sphinx. The aim of present study was to examine the mechanism by which leptin may inhibit progesterone, and therefore could be responsible for delayed development. The study showed a significant increase in circulating leptin level during the period of increased fat accumulation, which coincided with significant decrease in serum progesterone level and delayed embryonic development in C. sphinx. The study showed increased Ob-R expression in the corpus luteum and in the utero-embryonic unit during the period of delayed embryonic development. The in vitro study showed suppressive effect of leptin on progesterone synthesis. The effect of high dose of leptin on ovarian steroidogenesis was found to be mediated through decreased expression of StAR and LH-R proteins in the ovary. The treatment with leptin caused increased expression of STAT 3 and iNOS proteins in the ovary, which correlated with decreased expression of StAR protein in the ovary. The inhibitory effects of leptin on progesterone synthesis in the ovary are thus mediated through STAT 3 and iNOS-NO signaling pathways. This study further demonstrated low expression of PCNA coinciding with the increased concentration of the leptin receptor in the utero-embryonic unit and high circulating leptin level during November. In conclusion, adiposity associated increased leptin level during November-December might play role in suppressing progesterone synthesis in the corpus luteum as well as suppressing the rate of cell-proliferation in the utero-embryonic unit thereby causing delayed embryonic development in C. sphinx. Copyright 2010 Elsevier Inc. All rights reserved.

  16. Delayed post-treatment with bone marrow-derived mesenchymal stem cells is neurorestorative of striatal medium-spiny projection neurons and improves motor function after neonatal rat hypoxia-ischemia.

    Science.gov (United States)

    Cameron, Stella H; Alwakeel, Amr J; Goddard, Liping; Hobbs, Catherine E; Gowing, Emma K; Barnett, Elizabeth R; Kohe, Sarah E; Sizemore, Rachel J; Oorschot, Dorothy E

    2015-09-01

    Perinatal hypoxia-ischemia is a major cause of striatal injury and may lead to cerebral palsy. This study investigated whether delayed administration of bone marrow-derived mesenchymal stem cells (MSCs), at one week after neonatal rat hypoxia-ischemia, was neurorestorative of striatal medium-spiny projection neurons and improved motor function. The effect of a subcutaneous injection of a high-dose, or a low-dose, of MSCs was investigated in stereological studies. Postnatal day (PN) 7 pups were subjected to hypoxia-ischemia. At PN14, pups received treatment with either MSCs or diluent. A subset of high-dose pups, and their diluent control pups, were also injected intraperitoneally with bromodeoxyuridine (BrdU), every 24h, on PN15, PN16 and PN17. This permitted tracking of the migration and survival of neuroblasts originating from the subventricular zone into the adjacent injured striatum. Pups were euthanized on PN21 and the absolute number of striatal medium-spiny projection neurons was measured after immunostaining for DARPP-32 (dopamine- and cAMP-regulated phosphoprotein-32), double immunostaining for BrdU and DARPP-32, and after cresyl violet staining alone. The absolute number of striatal immunostained calretinin interneurons was also measured. There was a statistically significant increase in the absolute number of DARPP-32-positive, BrdU/DARPP-32-positive, and cresyl violet-stained striatal medium-spiny projection neurons, and fewer striatal calretinin interneurons, in the high-dose mesenchymal stem cell (MSC) group compared to their diluent counterparts. A high-dose of MSCs restored the absolute number of these neurons to normal uninjured levels, when compared with previous stereological data on the absolute number of cresyl violet-stained striatal medium-spiny projection neurons in the normal uninjured brain. For the low-dose experiment, in which cresyl violet-stained striatal medium-spiny neurons alone were measured, there was a lower statistically

  17. Visual-Motor Integration in Children with Prader-Willi Syndrome

    Science.gov (United States)

    Lo, S. T.; Collin, P. J. L.; Hokken-Koelega, A. C. S.

    2015-01-01

    Background: Prader-Willi syndrome (PWS) is characterised by hypotonia, hypogonadism, short stature, obesity, behavioural problems, intellectual disability, and delay in language, social and motor development. There is very limited knowledge about visual-motor integration in children with PWS. Method: Seventy-three children with PWS aged 7-17 years…

  18. Morphological features of the neonatal brain support development of subsequent cognitive, language, and motor abilities.

    Science.gov (United States)

    Spann, Marisa N; Bansal, Ravi; Rosen, Tove S; Peterson, Bradley S

    2014-09-01

    Knowledge of the role of brain maturation in the development of cognitive abilities derives primarily from studies of school-age children to adults. Little is known about the morphological features of the neonatal brain that support the subsequent development of abilities in early childhood, when maturation of the brain and these abilities are the most dynamic. The goal of our study was to determine whether brain morphology during the neonatal period supports early cognitive development through 2 years of age. We correlated morphological features of the cerebral surface assessed using deformation-based measures (surface distances) of high-resolution MRI scans for 33 healthy neonates, scanned between the first to sixth week of postmenstrual life, with subsequent measures of their motor, language, and cognitive abilities at ages 6, 12, 18, and 24 months. We found that morphological features of the cerebral surface of the frontal, mesial prefrontal, temporal, and occipital regions correlated with subsequent motor scores, posterior parietal regions correlated with subsequent language scores, and temporal and occipital regions correlated with subsequent cognitive scores. Measures of the anterior and middle portions of the cingulate gyrus correlated with scores across all three domains of ability. Most of the significant findings were inverse correlations located bilaterally in the brain. The inverse correlations may suggest either that a more protracted morphological maturation or smaller local volumes of neonatal brain tissue supports better performance on measures of subsequent motor, language, and cognitive abilities throughout the first 2 years of postnatal life. The correlations of morphological measures of the cingulate with measures of performance across all domains of ability suggest that the cingulate supports a broad range of skills in infancy and early childhood, similar to its functions in older children and adults. Copyright © 2014 Wiley Periodicals, Inc.

  19. FY1995 development of artificial arm 'SMART ARM' by spherical ultrasonic motor; 1995 nendo kyumen choonpa motor wo mochiita jinko gishu smart arm no kaihatsu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-03-01

    The project has an intention of development of new type artificial arm by spherical ultrasonic motor. We have succeeded in developing new type of spherical ultrasonic motor with three DOF. And we have succeeded in applying the motor to an artificial arm. This arm have advantages of small size, low weight torque comparing with conventional ones. We demonstrated them the new arm behaved well and it had good controlabilty. (NEDO)

  20. Development of High-Speed Switched Reluctance Motor for Electric Power Tools

    Science.gov (United States)

    Nakamura, Kenji; Kumasaka, Yuya; Ichinokura, Osamu

    2017-10-01

    This paper presents design and experimental evaluation of a switched reluctance (SR) motor used for electric power tools. First, characteristics of a previous designed 6/4-pole SR motor is shown and compared to a permanent magnet (PM) motor used in present electric power tools. Next, to further improve characteristics, a 12/8-pole SR motor is designed and evaluated in experiment. It is proved that the performance of the prototype 12/8-pole SR motor is almost comparable or superior to the present PM motor.

  1. Can Adolescents Learn Self-control? Delay of Gratification in the Development of Control over Risk Taking

    Science.gov (United States)

    Duckworth, Angela L.; Sznitman, Sharon; Park, Sunhee

    2010-01-01

    Recent findings from developmental neuroscience suggest that the adolescent brain is too immature to exert control over impulsive drives, such as sensation seeking, that increase during adolescence. Using a discounting of delayed reward paradigm, this research examines the ability to delay gratification as a potential source of control over risk-taking tendencies that increase during adolescence. In addition, it explores the role of experience resulting from risk taking as well as future time perspective as contributors to the development of this ability. In a nationally representative sample (n=900) of young people aged 14–22, a structural equation analysis shows that risk taking as assessed by use of three popular drugs (tobacco, marijuana, and alcohol) is inversely related to the ability to delay gratification. The relation is robust across gender, age, and different levels of sensation seeking. In addition, high sensation seekers exhibit dramatic age-related increase in delay of gratification, lending support to the hypothesis that engaging in risky behavior provides experience that leads to greater patience for long-term rewards. The findings support the conclusion that a complete understanding of the development of self-control must consider individual differences not easily explained by universal trends in brain maturation. PMID:20306298

  2. Urinary Levels of IL-1β and GDNF in Preterm Neonates as Potential Biomarkers of Motor Development: A Prospective Study

    Directory of Open Access Journals (Sweden)

    Rafael Coelho Magalhães

    2017-01-01

    Full Text Available Objectives. To evaluate the association between inflammatory biomarkers, neurotrophic factors, birth conditions, and the presence of motor development abnormalities in preterm neonates. Methods. Plasma and urinary levels of cytokines (IL-1β, IL-6, IL-10, TNF, and IL-12p70, chemokines (CXCL8/IL-8, CCL2/MCP-1, CCL5/RANTES, CXCL10/IP-10, and CXCL9/MIG, and neurotrophic factors (BDNF and GDNF were evaluated in 40 preterm neonates born between 28 and 32 incomplete weeks of gestation, at four distinct time points: at birth (umbilical cord blood (T0, at 48 (T1, at 72 hours (T2, and at 3 weeks after birth (T3. Biomarkers levels were compared between different time points and then associated with Test of Infant Motor Performance (TIMP percentiles. Results. Maternal age, plasma, and urinary concentrations of inflammatory molecules and neurotrophic factors were significantly different between groups with normal versus lower than expected motor development. Higher levels of GDNF were found in the group with lower than expected motor development, while IL-1β and CXCL8/IL-8 values were higher in the group with typical motor development. Conclusion. Measurements of cytokines and neurotrophic factors in spot urine may be useful in the follow-up of motor development in preterm neonates.

  3. Development of friction welding method by electric servo motors; Dendo servo shiki masatsu assetsuho no kaihatsu

    Energy Technology Data Exchange (ETDEWEB)

    Suzuki, H; Onuma, M; Hasegawa, T; Sakamoto, T [Toyota Motor Corp., Aichi (Japan)

    1997-10-01

    The standard friction welding has two methods; the brake method and the inertia method. We have developed a new friction welding method with the electric servo motor system. The forming of plastic fluidity layers of interface is evaluated quantitatively with the feedback control characteristics. The new method has enabled to reduce the heat effect and the burr of friction welding. In the method, we could reduce the getting heat energy, from one-third to half less than the previous methods. 6 refs., 16 figs.

  4. Development of Vestibular Stochastic Resonance as a Sensorimotor Countermeasure: Improving Otolith Ocular and Motor Task Responses

    Science.gov (United States)

    Mulavara, Ajitkumar; Fiedler, Matthew; DeDios,Yiri E.; Galvan, Raquel; Bloomberg, Jacob; Wood, Scott

    2011-01-01

    Astronauts experience disturbances in sensorimotor function after spaceflight during the initial introduction to a gravitational environment, especially after long-duration missions. Stochastic resonance (SR) is a mechanism by which noise can assist and enhance the response of neural systems to relevant, imperceptible sensory signals. We have previously shown that imperceptible electrical stimulation of the vestibular system enhances balance performance while standing on an unstable surface. The goal of our present study is to develop a countermeasure based on vestibular SR that could improve central interpretation of vestibular input and improve motor task responses to mitigate associated risks.

  5. Advanced Motor Control Test Facility for NASA GRC Flywheel Energy Storage System Technology Development Unit

    Science.gov (United States)

    Kenny, Barbara H.; Kascak, Peter E.; Hofmann, Heath; Mackin, Michael; Santiago, Walter; Jansen, Ralph

    2001-01-01

    This paper describes the flywheel test facility developed at the NASA Glenn Research Center with particular emphasis on the motor drive components and control. A four-pole permanent magnet synchronous machine, suspended on magnetic bearings, is controlled with a field orientation algorithm. A discussion of the estimation of the rotor position and speed from a "once around signal" is given. The elimination of small dc currents by using a concurrent stationary frame current regulator is discussed and demonstrated. Initial experimental results are presented showing the successful operation and control of the unit at speeds up to 20,000 rpm.

  6. Development of Interior Permanent Magnet Motors with Concentrated Windings for Reducing Magnet Eddy Current Loss

    Science.gov (United States)

    Yamazaki, Katsumi; Kanou, Yuji; Fukushima, Yu; Ohki, Shunji; Nezu, Akira; Ikemi, Takeshi; Mizokami, Ryoichi

    In this paper, we present the development of interior magnet motors with concentrated windings, which reduce the eddy current loss of the magnets. First, the mechanism of the magnet eddy current loss generation is investigated by a simple linear magnetic circuit. Due to the consideration, an automatic optimization method using an adaptive finite element method is carried out to determine the stator and rotor shapes, which decrease the eddy current loss of the magnet. The determined stator and rotor are manufactured in order to proof the effectiveness by the measurement.

  7. Avaliação e intervenção no desenvolvimento motor de uma criança com Síndrome de Down Assessment and intervention in the motor development of a child with Down Syndrome

    Directory of Open Access Journals (Sweden)

    Ana Paula Maurilia dos Santos

    2010-04-01

    Full Text Available o objetivo deste estudo foi analisar o desenvolvimento motor de uma criança com síndrome de Down e verificar os efeitos de um programa de intervenção motora específica. Trata-se de uma pesquisa descritiva do tipo estudo de caso. Para a avaliação do desenvolvimento motor foram utilizados os testes da Escala de Desenvolvimento Motor - EDM que analisa as áreas da motricidade fina e global, equilíbrio, esquema corporal, organização espacial e temporal/linguagem, e lateralidade. Essa criança participou, respectivamente, de avaliação motora, intervenção motora (32 sessões, 2 vezes semanais e reavaliação motora. As intervenções motoras mostraram avanços positivos nas áreas da motricidade global, equilíbrio e organização espacial. A motricidade fina, esquema corporal e a organização temporal /linguagem não apresentaram avanços. Verificou-se que a linguagem foi a área de maior prejuízo. O quociente motor em todos os itens foi classificado como muito inferior, o que se caracteriza como déficit motor. Esses dados justificam a relevância de programas de intervenção motora para essa população.the objective of this study was to analyze the motor development of a child with Down syndrome and to verify the effect of a specific motor intervention program. This is a descriptive research case study. Motor development was evaluated using the Motor Development Scale - MDS, which analyzes both fine and gross motor skills as well as balance, body schema, spatial and temporal organization, language, and laterality. This child participated, respectively, of the motor assessment, motor intervention (32 sessions, twice weekly and motor reevaluation. Gains were demonstrated in motor intervention in the areas of the gross motor skills, balance and spatial organization. No improvement was shown in fine motor skills, body schema and temporal organization/ language. Language was found to be the area of lowest achievement. The motor

  8. Influence of motor skills training on children’s development evaluated in the Motor skills in PreSchool (MiPS) study-DK: study protocol for a randomized controlled trial, nested in a cohort study

    DEFF Research Database (Denmark)

    Hestbaek, Lise; Andersen, Sara Thurøe; Skovgaard, Thomas

    2017-01-01

    BACKGROUND: Good motor skills are considered important for children's physical, social, and psychological development, but the relationship is still poorly understood. Preschool age seems to be decisive for the development of motor skills and probably the most promising time-window in relation...... to preventive strategies based on improved motor skills. This research program has four overall aims: (1) investigation of the effect of a structured program aimed at improving motor skills in 3-6-year-old children on current and future motor skills, health, cognition, and wellbeing; (2) establish reference...... data on motor skills in 3-6-year-olds; (3) description of early development of musculoskeletal problems; and (4) establishment of a population-based cohort of 3-6-year-olds. METHODS: Over a four-year period, all preschools in a Danish municipality, Svendborg, will implement a new program aimed...

  9. Development of an X-ray delay unit for correlation spectroscopy and pump-probe experiments

    Energy Technology Data Exchange (ETDEWEB)

    Roseker, Wojciech

    2008-07-15

    Probing condensed matter on time scales ranging from femtoseconds to nanoseconds will be one of the key topics for future X-ray Free Electron Laser (XFEL) sources. The accessible time windows are, however, compromised by the intrinsic time structure of the sources. One way to overcome this limitation is the usage of a time delay unit. A prototype device capable of splitting an X-ray pulse into two adjustable fractions, delaying one of them with the aim to perform X-ray Photon Correlation Spectroscopy and pump-probe type studies was designed and manufactured. The device utilizes eight perfect crystals in vertical 90 scattering geometry. Its performance has been verified with 8.39 keV and 12.4 keV Xrays at various synchrotron sources. The measured throughput of the device with a Si(333) monochromator at 8.39 keV under ambient conditions is 0.6%. The stability was verified at 12.4 keV and operation without realignment and feedback was possible for more than 30 minutes. Time delays up to 2.95 ns have been achieved. The highest resolution achieved in an experiment was 15.4 ps, a value entirely determined by the diagnostics system. The influence of the delay unit optics on the coherence properties of the beam was investigated by means of Fraunhofer diffraction and static speckle analysis. The obtained high fringe visibility and contrast values larger than 23% indicate the feasibility of performing coherence based experiments with the delay line. (orig.)

  10. Feeding behaviors and other motor development in healthy children (2-24 months).

    Science.gov (United States)

    Carruth, Betty Ruth; Skinner, Jean D

    2002-04-01

    To monitor infant's gross, fine and oral motor development patterns related to feeding. An incomplete block design was used with 57 to 60 (sample = 98) mothers interviewed when their children were 2, 3, 4, 6, 8, 10, 12, 16 and 24 months (within +/- 5 days of birth date). Each mother had 5 to 6 interviews. Selected developmental feeding behaviors were monitored using in-home interviews conducted by trained interviewers (n = 2). At each interview, mothers reported the child's age when behaviors first occurred, and anthropometric measurements were performed. Subjects were healthy white children who lived mostly in homes with educated two-parent families of upper socioeconomic status. Mean behavioral ages were within normal ranges reported in the literature, whereas individuals exhibited a wide diversity in reported ages. Examples of gross motor skills (age in months, +/- SD) included sitting without help (5.50+/-2.08) and crawling (8.00+/-1.55). Mean ages for self-feeding fine motor skills showed children reaching for a spoon when hungry (5.47+/-1.44), using fingers to rake food toward self (8.87+/-2.58) and using fingers to self-feed soft foods (13.52+/-2.83). Oral behaviors included children opening their mouth when food approached (4.46+/-1.37), eating food with tiny lumps (8.70+/-2.03) and chewing and swallowing firmer foods without choking (12.17+/-2.28). Mean ages for feeding behaviors occurred within expected age ranges associated with normal development. However, mothers reported that individual children exhibited a wide age range for achieving these behaviors. Our results should be considered in counseling mothers about infant feeding practices.

  11. Organization of Physical Activities as a Precondition of Quality Development of Motor Abilities of Pre-School and School Children

    Science.gov (United States)

    Markovic, Živorad; Kopas-Vukašinovic, Emina

    2015-01-01

    In their work authors consider the significance of the organization of physical activities for the development of abilities of pre-school and school children. Led by theoretical basis that physical development of children represents the basis of their whole development, and that "fine motor skills" are determined by the development of…

  12. Peripheral nerve injury in developing rats reorganizes representation pattern in motor cortex.

    OpenAIRE

    Donoghue, J P; Sanes, J N

    1987-01-01

    We investigated the effect of neonatal nerve lesions on cerebral motor cortex organization by comparing the cortical motor representation of normal adult rats with adult rats that had one forelimb removed on the day of birth. Mapping of cerebral neocortex with electrical stimulation revealed an altered relationship between the motor cortex and the remaining muscles. Whereas distal forelimb movements are normally elicited at the lowest threshold in the motor cortex forelimb area, the same stim...

  13. The malleability of infant motor development: cautions based on studies of child-rearing practices in Yucatan.

    Science.gov (United States)

    Solomons, H C

    1978-11-01

    Tests with the Bayley Motor Scale were given to 288 infants, equally divided by sex, in Yucatan, Mexico. These were 2 to 54 weeks in age and came from three sociocultural levels. In comparison to USA infants, early acceleration of motor development was followed by a marked downward trend. This phenomenon, if observed in a single child, may indicate progressive neurologic disease. Child-rearing practices would appear to account for the difference in pattern of test performance.

  14. Organization of Physical Activities as a Precondition of Quality Development of Motor Abilities of Pre-School and School Children

    Directory of Open Access Journals (Sweden)

    Marković Živorad

    2015-08-01

    Full Text Available In their work authors consider the significance of the organization of physical activities for the development of abilities of pre-school and school children. Led by theoretical basis that physical development of children represents the basis of their whole development, and that “fine motor skills” are determined by the development of its large motorics, the authors point to the significance of the content and structure of physical education programme in preschool institutions and younger age school classes. It is evident that the effects of cultivating of children development during preschool period can be seen in younger primary school classes. The goal of this research was to determine if and how much the different organization of preparatory part of physical education lesson for younger school children, determines the differences in the development of their motor abilities. By the use of experimental method, the effects of prolonged preparatory part of a lesson in younger school classes. This part was realized through complex of exercises which were supposed to have influence on transformation of motor abilities in relation to the structure with standard duration of certain parts of a lesson. It is determined that certain increase in body movement of students during physical activity can significantly contribute to better development of motor abilities. These abilities determine correct physical development and strengthening of health, which determines general aim of physical education.

  15. Development in Children with Achondroplasia: A Prospective Clinical Cohort Study

    Science.gov (United States)

    Ireland, Penelope J.; Donaghey, Samantha; McGill, James; Zankl, Andreas; Ware, Robert S.; Pacey, Verity; Ault, Jenny; Savarirayan, Ravi; Sillence, David; Thompson, Elizabeth; Townshend, Sharron; Johnston, Leanne M.

    2012-01-01

    Aim: Achondroplasia is characterized by delays in the development of communication and motor skills. While previously reported developmental profiles exist across gross motor, fine motor, feeding, and communication skills, there has been no prospective study of development across multiple areas simultaneously. Method: This Australasian…

  16. New perspectives on the development of muscle contractures following central motor lesions

    DEFF Research Database (Denmark)

    Pingel, Jessica; Bartels, Else Marie; Nielsen, Jens Bo

    2017-01-01

    Muscle contractures are common in patients with central motor lesions, but the mechanisms responsible for the development of contractures are still unclear. Increased or decreased neural activation, protracted placement of a joint with the muscle in a short position and muscle atrophy have been...... suggested to be involved, but none of these mechanisms are sufficient to explain the development of muscle contractures alone. Here we propose that changes in tissue homeostasis in the neuro-muscular-tendon-connective tissue complex is at the heart of the development of contractures, and that an integrated...... physiological understanding of the interaction between neural, mechanical and metabolic factors, as well as genetic and epigenetic factors, is necessary in order to unravel the mechanisms that result in muscle contractures. We hope thereby to contribute to a reconsideration of how and why muscle contractures...

  17. [Comparing development with physical fitness, motor ability, and health of children among various living environment].

    Science.gov (United States)

    Nagata, A; Takimoto, M; Ishida, R

    1989-10-01

    This study had the purpose to compare with development of fitness, motor ability and health among various living environments of the sea-side, the urban, and the mountain districts, where were situated at Nadachi town on the suburbs of Niigata Prefecture. Five hundred thirty-five children (aged 4-15 yrs) were measured at the kindergarten, the fundamental school, and the junior high school. Measuring items of the physique were the height, the weight, the chest circumference, the sitting height, and the foot area. Physical fitness tests were the muscular grip-strength, the lung vital capacity, the closed-eye single-leg balance, the dipping time of the upper extremity, the vertical jump, the standing trunk flexibility, the endurance run, and pull-up. And, motor ability tests were the finger tapping, 5m shuttle run, 50m dash, and the ball throwing. As items of health inspection, the blood pressure (systolic and diasystolic) and the visual ability were adopted. As results of this study, following data were obtained; 1) At the sea-side environment, development of the muscle power, the respiratory function, and the physique were showed much faster rate of growth at the childhood than that of the other ones, significantly (P less than 0.01). 2) At the mountain environment, the arch-bend of the foot print only were appeared larger areas than that of the other ones, significantly (P less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)

  18. Development of 1 MW-class HTS motor for podded ship propulsion system

    Energy Technology Data Exchange (ETDEWEB)

    Umemoto, K; Aizawa, K; Yokoyama, M; Yoshikawa, K [Kawasaki Heavy Industries LTD., 673-8666, Hyogo (Japan); Kimura, Y; Izumi, M [Tokyo University of Marine Science Technology, 135-8533, Tokyo (Japan); Ohashi, K; Numano, M [National Maritime Research Institute, 181-0004, Tokyo (Japan); Okumura, K; Yamaguchi, M; Gocho, Y; Kosuge, E, E-mail: umemoto@ati.khi.co.j [Japan Super-conductivity Organization Co. LTD., 135-8533, Tokyo (Japan)

    2010-06-01

    To reduce fuel consumption and lead to a major reduction of pollution from NOx, SOx and CO{sub 2}, the electric ship propulsion system is one of the most prospective substitutes for conventional ship propulsion systems. In order to spread it, innovative technologies for the improvement of the power transmission are required. The high temperature superconducting technology has the possibility for a drastic reduction of power transmission loss. Recently, electric podded propulsions have become popular for large cruise vessels, icebreakers and chemical tankers because of the flexibility of the equipment arrangement and the stern hull design, and better maneuverability in harbour, etc. In this paper, a 1 MW-class High temperature superconducting (HTS) motor with high efficiency, smaller size and simple structure, which is designed and manufactured for podded propulsion, is reported. For the case of a coastal ship driven by the optimized podded propulsion in which the 1MW HTS motor is equipped, the reductions of fluid dynamic resistance and power transmission losses are demonstrated. The present research and development has been supported by the New Energy and Industrial Technology Development Organization (NEDO).

  19. Digital Trainer for the Development of the Fine Motor Ability in Children with Cerebral Palsy

    Directory of Open Access Journals (Sweden)

    Berrezueta-Guzmán Jonnathan

    2016-01-01

    Full Text Available The leading cause of disability in Ecuadorian children is cerebral palsy, this disorder in most cases produces a deficiency of the ability to move fingers, hands and wrists at various levels, this happens too with the intellect of the patient. Many of the treatments and therapies are seeking that the patient can develop all of your motor ability and intellectual skills, using activities that involve the part Intellectual and practicality of their extremities. Today technology gives us the opportunity to manage devices of aid and assistance that not only complement the daily activities that are performed during the therapies in the help centers, they need to give results that show leaps and bounds in the progress that you want to get. The purpose of this project is to make a device that helps a patient to develop their fine motor ability to the patient can use their hands, fingers and wrists movements in various ways in coordination with their vision in conjunction with occipital lobe causing that brain activity in the patient, present alterations of amplitude in the beta waves in the hemispheres of the brain that allow move muscles, with only maneuver a fully digital device and low cost. These brain and muscles signals will be analyzed in this project, to test the efficiency of this project.

  20. MRI in spastic cerebral palsy - correlations with motor development and mental retardation

    International Nuclear Information System (INIS)

    Kulal, W.; Sobaniec, W.; Kubas, B.

    2004-01-01

    The introduction of magnetic resonance (MR) has improved our understanding of the pathophysiology and early diagnosis of cerebral palsy (CP). The aim of this study was to evaluate types of lesions on MR in children with CP in correlations with motor development, cognitive impairment and risk factors. Twenty-two children aged 4-17 years (boys 12, girls 10) with CP diplegia - 16 and tetraplegia - 6 were studied. Routine MR images were performed in all children. Results: All patients had periventricular leukomalacia (PVL) in MR findings. In addition three different degrees of MRI lesion patterns were defined: a mild pattern (nucleus lentiformis and thalamus) moderate (nucleus lentiformis, thalamus and pericentral region)and a severe pattern (nucleus lentiformis , thalamus, pericentral region and hippocampus). Significant correlations of the MR findings with the motor development and mental retardation were found. No significant relationships between the MR findings and the etiological factors (prematurity, low birthweight, Apgar score, sepsis, seizures, pre-eclamsia , and gestational age) were noted. MR imaging is useful in the evaluation structural abnormalities in the brains in the children with spastic diplegia and tetraplegia. (author)

  1. A study on the development of the computerized safety evaluation system of the motor operated valve

    International Nuclear Information System (INIS)

    Kim, J. C.; Park, S. G.; Lee, D. H.; Ahn, N. S.; Bae, H. J.; Hong, J. S.

    2001-01-01

    The MOVIDIK (Motor-Operated Valves Integrated Database and Information of KEPCO) system was developed to assist the design basis safety evaluation and to manage the overall data made by evaluation on the safety-related Motor-operated Valves(MOV) in the nuclear power plant. The huge amount of safety evaluation data of the MOV is being piled up as the safety evaluation work goes on. Much time and manpower was needed to do safety evaluation works without computerized system and it was not easy to obtain the statistic information from the evaluation data. The MOVIDIK will improve the efficiency of safety evaluation works and standardize the analysis process. But the some process which needs specific evaluation codes and engineering calculation by the specialists was not computerized. The MOVIDIK was developed by JAVA/JSP language known by the flexibility of language and the easiness of transplantation between operating systems. The Oracle 8i which is the world's most popular database was used for MOVIDIK database

  2. Abbreviated exposure to hypoxia is sufficient to induce CNS dysmyelination, modulate spinal motor neuron composition, and impair motor development in neonatal mice.

    Directory of Open Access Journals (Sweden)

    Jens O Watzlawik

    Full Text Available Neonatal white matter injury (nWMI is an increasingly common cause of cerebral palsy that results predominantly from hypoxic injury to progenitor cells including those of the oligodendrocyte lineage. Existing mouse models of nWMI utilize prolonged periods of hypoxia during the neonatal period, require complex cross-fostering and exhibit poor growth and high mortality rates. Abnormal CNS myelin composition serves as the major explanation for persistent neuro-motor deficits. Here we developed a simplified model of nWMI with low mortality rates and improved growth without cross-fostering. Neonatal mice are exposed to low oxygen from postnatal day (P 3 to P7, which roughly corresponds to the period of human brain development between gestational weeks 32 and 36. CNS hypomyelination is detectable for 2-3 weeks post injury and strongly correlates with levels of body and brain weight loss. Immediately following hypoxia treatment, cell death was evident in multiple brain regions, most notably in superficial and deep cortical layers as well as the subventricular zone progenitor compartment. PDGFαR, Nkx2.2, and Olig2 positive oligodendrocyte progenitor cell were significantly reduced until postnatal day 27. In addition to CNS dysmyelination we identified a novel pathological marker for adult hypoxic animals that strongly correlates with life-long neuro-motor deficits. Mice reared under hypoxia reveal an abnormal spinal neuron composition with increased small and medium diameter axons and decreased large diameter axons in thoracic lateral and anterior funiculi. Differences were particularly pronounced in white matter motor tracts left and right of the anterior median fissure. Our findings suggest that 4 days of exposure to hypoxia are sufficient to induce experimental nWMI in CD1 mice, thus providing a model to test new therapeutics. Pathological hallmarks of this model include early cell death, decreased OPCs and hypomyelination in early postnatal life

  3. Lactational exposure to hexavalent chromium delays puberty by impairing ovarian development, steroidogenesis and pituitary hormone synthesis in developing Wistar rats

    International Nuclear Information System (INIS)

    Banu, Sakhila K.; Samuel, Jawahar B.; Arosh, Joe A.; Burghardt, Robert C.; Aruldhas, Michael M.

    2008-01-01

    Hexavalent chromium (Cr-VI) is used in a wide range of industries. Cr-VI from chromate industries and atmospheric emissions contribute to the Cr contamination in the environment. Cr is a reproductive metal toxicant that can traverse the placental barrier and cause a wide range of fetal effects including ovotoxicity. Therefore, the goal of this study was to investigate the basic mechanisms involved in Cr(VI)-induced ovotoxicity, and the protective role of vitamin C on ovarian follicular development and function in Cr(VI)-induced reproductive toxicity using both in vivo and in vitro approaches. Lactating rats received potassium dichromate (200 mg/L) with or without vitamin C (500 mg/L), through drinking water from postpartum days 1-21. During postnatal days (PND) 1-21 the pups received Cr(VI) via the mother's milk. Pups from both control and treatment groups were continued on regular diet and water from PND-21 onwards, and euthanized on PND-21, -45 and -65. Cr(VI) decreased steroidogenesis, GH and PRL, increased FSH and did not alter LH. Cr(VI) delayed puberty, decreased follicle number, and extended estrous cycle. Spontaneously immortalized rat granulosa cells were treated with 12.5 μM (IC 50 ) potassium dichromate for 12 and 24 h, with or without vitamin C pre-treatment. Cr(VI) decreased the mRNA expressions of StAR, SF-1, 17β-HSD-1, 17β-HSD-2, FSHR, LHR, ERα and ERβ. Vitamin C pre-treatment protected ovary and granulosa cells from the deleterious effects of Cr(VI) toxicity, both in vivo and in vitro. Therefore, Cr(VI) toxicity could be a potential risk to the reproductive system in developing females, and vitamin C plays a protective role against Cr(VI)-induced ovotoxicity

  4. Co-occurring development of early childhood communication and motor skills: results from a population-based longitudinal study.

    Science.gov (United States)

    Wang, M V; Lekhal, R; Aarø, L E; Schjølberg, S

    2014-01-01

    Communicative and motor development is frequently found to be associated. In the current study we investigate to what extent communication and motor skills at 1½ years predict skills in the same domains at 3 years of age. This study is based on the Norwegian Mother and Child Cohort Study (MoBa) conducted by the Norwegian Institute of Public Heath. Data stem from 62,944 children and their mothers. Mothers completed questionnaires on their child's communication and motor skills at ages 1½ and 3. Associations between communication and motor skills were estimated in a cross-lagged model with latent variables. Early communication skills were correlated with early motor skills (0.72). Stability was high (0.81) across time points for motor skills and somewhat lower (0.40) for communication skills. Early motor skills predicted later communication skills (0.38) whereas early communication skills negatively predicted later motor skills (-0.14). Our findings provide support for the hypothesis that these two difficulties are not symptoms of separate disorders, but might rather be different manifestations of a common underlying neurodevelopmental weakness. However, there also seem to be specific developmental pathways for each domain. Besides theoretical interest, more knowledge about the relationship between these early skills might shed light upon early intervention strategies and preventive efforts commonly used with children with problems in these areas. Our findings suggest that the relationship between language and motor skills is not likely to be simple and directional but rather to be complex and multifaceted. © 2012 John Wiley & Sons Ltd.

  5. MR findings of congenital craniocerebral anomaly: correlation with seizures and development delay

    International Nuclear Information System (INIS)

    Ko, Seog Wan; Seo, Jeong Jin; Kim, Yun Hyeon; Yoon, Jong Hun; Kim, Hyun Ju; Kim, Hyeong Kil; Kang, Heoung Keun; Chung, Hyon De

    1995-01-01

    To evaluate characteristic MR findings of craniocerebral anomaly and its relationship with neurologic manifestations. We retrospectively reviewed MR images of 36 patients with craniocerebral anomaly diagnosed by MRI and clinical courses. We correlated the characteristic MR findings in 41 lesions with neurologic manifestations focusing on seizures and developmental delay. Twenty-three patients with seizures consisted of 14 patients(60%) with neuronal migration disorders and seven(30%) with phakomatosis, among which 18 patients(78%) had generalized type of seizures. Locations of the lesions were the parietal lobes in 11 patients(52%) and the subependymal or periventricular regions in seven(33%). Two patients with tuberous sclerosis had the lesions in both parietal and subependymal areas. Nine patients had the signs of developmental delay that were seen in the four(44%) with schizencephaly, two (22%) with tuberous sclerosis, two(22%) with heterotopia, and noe(11%) with pachygyria. Neuronal migration anomaly was relatively common lesion that presented neurologic festations such as seizures and developmental delay. Generalized type of seizures were common. We were able to diagnose these anomalies using the MRI that helped establish therapeutic plans

  6. Development of a New Method for Assembling a Bipolar DC Motor as a Teaching Material

    Science.gov (United States)

    Matsumoto, Yuki; Sakaki, Kei; Sakaki, Mamoru

    2017-05-01

    A simple handmade motor is a commonly used teaching aid for explaining the theory of the DC motor in science classes around the world. Kits that can be used by children to craft a simple motor are commercially available, and videos of assembling these motors are easily found on the internet. Although the design of this motor is simple, it is unipolar, meaning that the rotor consists of a single dipole. Thus, the Lorentz force acts only on one side of the coil per revolution. This decreases the energy conversion efficiency and requires the learners to turn the rotor using their hands in order to initiate rotation.

  7. Delayed Puberty

    DEFF Research Database (Denmark)

    Kolby, Nanna; Busch, Alexander Siegfried; Juul, Anders

    2017-01-01

    . The underlying reasons for the large variation in the age at pubertal onset are not fully established; however, nutritional status and socioeconomic and environmental factors are known to be influencing, and a significant amount of influencing genetic factors have also been identified. The challenges...... optimal in discriminating especially CDGP from HH. Management of the delayed puberty depends on the etiology. For boys with CDGP an observational period will often reveal imminent puberty. If puberty is not progressing spontaneously, sex steroid replacement is effective in stimulating the development...

  8. Summary Report of 1st Research Coordination Meeting on Development of Reference Database for Beta-delayed Neutron Emission

    International Nuclear Information System (INIS)

    Dillmann, Iris; Dimitriou, Paraskevi; Singh, Balraj

    2014-03-01

    A summary is given of the 1st Research Coordination Meeting of the new IAEA Coordinated Research Project (CRP) on Development of a Reference Database for Beta-delayed neutron emission data. Participants presented their work, reviewed the current status of the field with regards to individual precursors and aggregate data, and discussed the scope of the work to be undertaken. A list of priorities and task assignments was produced. (author)

  9. The discovery of human auditory-motor entrainment and its role in the development of neurologic music therapy.

    Science.gov (United States)

    Thaut, Michael H

    2015-01-01

    The discovery of rhythmic auditory-motor entrainment in clinical populations was a historical breakthrough in demonstrating for the first time a neurological mechanism linking music to retraining brain and behavioral functions. Early pilot studies from this research center were followed up by a systematic line of research studying rhythmic auditory stimulation on motor therapies for stroke, Parkinson's disease, traumatic brain injury, cerebral palsy, and other movement disorders. The comprehensive effects on improving multiple aspects of motor control established the first neuroscience-based clinical method in music, which became the bedrock for the later development of neurologic music therapy. The discovery of entrainment fundamentally shifted and extended the view of the therapeutic properties of music from a psychosocially dominated view to a view using the structural elements of music to retrain motor control, speech and language function, and cognitive functions such as attention and memory. © 2015 Elsevier B.V. All rights reserved.

  10. The relationship between body mass index and gross motor development in children aged 3 to 5 years.

    Science.gov (United States)

    Nervik, Deborah; Martin, Kathy; Rundquist, Peter; Cleland, Joshua

    2011-01-01

    To investigate the relationship between obesity and gross motor development in children who are developing typically and determine whether body mass index (BMI) predicts difficulty in gross motor skills. BMIs were calculated and gross motor skills examined in 50 children who were healthy aged 3 to 5 years using the Peabody Developmental Motor Scales, 2nd edition (PDMS-2). Pearson chi-square statistic and stepwise linear hierarchical regression were used for analysis. A total of 24% of the children were overweight/obese, whereas 76% were found not to be overweight/obese. Fifty-eight percent of the overweight/obese group scored below average on the PDMS-2 compared to 15% of the nonoverweight group. Association between BMI and gross motor quotients was identified with significance of less than 0.002. Regression results were nonsignificant with all 50 subjects, yet showed significance (P = 0.018) when an outlier was excluded. Children aged 3 to 5 years with high BMIs may have difficulty with their gross motor skills. Further research is needed.

  11. Evolution and Development of the Inner Ear Efferent System: Transforming a Motor Neuron Population to Connect to the Most Unusual Motor Protein via Ancient Nicotinic Receptors

    Directory of Open Access Journals (Sweden)

    Bernd Fritzsch

    2017-04-01

    Full Text Available All craniate chordates have inner ears with hair cells that receive input from the brain by cholinergic centrifugal fibers, the so-called inner ear efferents (IEEs. Comparative data suggest that IEEs derive from facial branchial motor (FBM neurons that project to the inner ear instead of facial muscles. Developmental data showed that IEEs develop adjacent to FBMs and segregation from IEEs might depend on few transcription factors uniquely associated with IEEs. Like other cholinergic terminals in the peripheral nervous system (PNS, efferent terminals signal on hair cells through nicotinic acetylcholine channels, likely composed out of alpha 9 and alpha 10 units (Chrna9, Chrna10. Consistent with the evolutionary ancestry of IEEs is the even more conserved ancestry of Chrna9 and 10. The evolutionary appearance of IEEs may reflect access of FBMs to a novel target, possibly related to displacement or loss of mesoderm-derived muscle fibers by the ectoderm-derived ear vesicle. Experimental transplantations mimicking this possible aspect of ear evolution showed that different motor neurons of the spinal cord or brainstem form cholinergic synapses on hair cells when ears replace somites or eyes. Transplantation provides experimental evidence in support of the evolutionary switch of FBM neurons to become IEEs. Mammals uniquely evolved a prestin related motor system to cause shape changes in outer hair cells regulated by the IEEs. In summary, an ancient motor neuron population drives in craniates via signaling through highly conserved Chrna receptors a uniquely derived cellular contractility system that is essential for hearing in mammals.

  12. Development of a Test for Evaluating Beginning Taekwondo Students’ Motor Skills

    Directory of Open Access Journals (Sweden)

    Willy Pieter

    2012-07-01

    Full Text Available The purpose of the present investigation was to develop a motor skills test for beginners in tae-kwondo. Subjects were students enrolled in a beginning taekwondo class at a university on the West Coast of the USA. The taekwondo skills test battery was based on previous work in gymnastics and wrestling. Test-retest reliability, i.e., repeatability of the test, and objectivity coefficients, i.e., an index of the consistency between the raters, were calculated. The objectivity, i.e., a measure of the consistency between the raters over both days for Group 1 was very high, and for Group 2, high. The reliability, or the consistency of the results of the test when administered on two different occasions, was very high for both groups. Future research should comprise more subjects, while test batteries for intermediate and advanced students should be developed.

  13. Test of Gross Motor Development : Expert Validity, confirmatory validity and internal consistence

    Directory of Open Access Journals (Sweden)

    Nadia Cristina Valentini

    2008-12-01

    Full Text Available The Test of Gross Motor Development (TGMD-2 is an instrument used to evaluate children’s level of motordevelopment. The objective of this study was to translate and verify the clarity and pertinence of the TGMD-2 items by expertsand the confirmatory factorial validity and the internal consistence by means of test-retest of the Portuguese TGMD-2. Across-cultural translation was used to construct the Portuguese version. The participants of this study were 7 professionalsand 587 children, from 27 schools (kindergarten and elementary from 3 to 10 years old (51.1% boys and 48.9% girls.Each child was videotaped performing the test twice. The videotaped tests were then scored. The results indicated thatthe Portuguese version of the TGMD-2 contains clear and pertinent motor items; demonstrated satisfactory indices ofconfirmatory factorial validity (χ2/gl = 3.38; Goodness-of-fit Index = 0.95; Adjusted Goodness-of-fit index = 0.92 and Tuckerand Lewis’s Index of Fit = 0.83 and test-retest internal consistency (locomotion r = 0.82; control of object: r = 0.88. ThePortuguese TGMD-2 demonstrated validity and reliability for the sample investigated.

  14. MORE MINUTES OF PHYSICAL EDUCATION CLASSES SUPPORT MOTOR DEVELOPMENT IN PRESCHOOL CHILDREN

    Directory of Open Access Journals (Sweden)

    Judith Jiménez Díaz

    2010-12-01

    Full Text Available The aim of this study was to determine the effect of physical education classes in 12 fundamental motor skills (FMS. Preschool students (M = 6.09±0.5 years old were randomly assigned to a control group (6 boys and 7 girls who performed the regular preschool class (which includes one 30- minutes session per week; experimental group 1 (6 boys and 6 girls who received the regular preschool class plus 1 session of 30 minutes per week of the intervention program; or experimental group 2 (6 boys and 7 girls, who received the regular preschool class plus 1 session of 60 minutes per week of the intervention program; during 8 weeks (n=38. All participants performed the Test of Gross Motor Development (TGMD-2 before and after the study. A one-way MANOVA reflected a similar behavior in al FMS in the pre-test. A two-way MANOVA (group x time reflected no interaction in the 12 FMS; also in the 6 object control FMS; but there was an interaction in the 6 locomotor FMS. In conclusion, 90-minutes of physical education classes per week only benefit the FMS of galloping and hopping.

  15. Development and characterization of magnetic HTS bearings for a 400 kW synchronous HTS motor

    International Nuclear Information System (INIS)

    Kummeth, P; Ries, G; Nick, W; Neumueller, H-W

    2004-01-01

    Promising results of static and dynamic investigations on various journal type test bearings encouraged us to develop a scaled-up HTS bearing, able to carry the HTS rotor of a 400 kW superconducting motor. The stator, a YBCO hollow cylinder of 203 mm inner diameter and 250 mm length, is cooled by liquid nitrogen. Permanent magnet rings with a diameter of 200 mm were mounted on a shaft with alternating polarity. Characterization of the bearing capacity was performed with three different YBCO stators at temperatures between 66 and 86 K in a test set-up. A significant influence of the temperature was found. At a stator temperature of 72 K and a rotation frequency of 25 Hz (corresponding to nominal motor speed) a radial bearing force of 2700 N was measured for the shaft at centre position. Under rotation of the shaft the bearing capacity is reduced. At present our results range within the highest radial bearing capacities reported world-wide

  16. Development of Digital Control for High Power Permanent-Magnet Synchronous Motor Drives

    Directory of Open Access Journals (Sweden)

    Ming-Hung Chen

    2014-01-01

    Full Text Available This paper is concerned with the development of digital control system for high power permanent-magnet synchronous motor (PMSM to yield good speed regulation, low current harmonic, and stable output speed. The design of controller is conducted by digitizing the mathematical model of PMSM using impulse invariance technique. The predicted current estimator, which is insensitive to motor feedback currents, is proposed to function under stationary frame for harmonic current suppression. In the AC/DC power converter, mathematical model and dc-link voltage limit of the three-phase switch-mode rectifier are derived. In addition, a current controller under synchronous frame is introduced to reduce the current harmonics and increase the power factor on the input side. A digital control system for 75 kW PMSM is realized with digital signal processor (R5F5630EDDFP. Experimental results indicate that the total harmonic distortion of current is reduced from 4.1% to 2.8% for 50 kW output power by the proposed predicted current estimator technique.

  17. Specific language impairment as a maturational lag: evidence from longitudinal data on language and motor development.

    Science.gov (United States)

    Bishop, D V; Edmundson, A

    1987-08-01

    Longitudinal language-test data on 87 language-impaired children assessed at the ages of four, 4 1/2 and 5 1/2 years were converted to age-equivalent scores to compare the rates of development of children who recover from early language delay with those who have more persisting problems. On most measures, over the 18-month period all the children progressed by about 18 months. Thus although children with good and poor outcomes were distinguished in terms of initial level of performance, they did not differ in rate of progress. Speed on a peg-moving task was closely related to language performance. Children who had a good outcome after early language delay had significantly impaired scores at four years, but subsequently were indistinguishable from a control group. Quantitative but not qualitative differences in peg-moving performance were found for children with good and poor outcomes. No association was found between presumptive aetiological factors and language or pegboard performance. These findings are interpreted in terms of a theory which attributes specific language impairment to a maturational lag in neurological development.

  18. Effects of music therapy in the treatment of children with delayed speech development - results of a pilot study

    Science.gov (United States)

    2010-01-01

    Background Language development is one of the most significant processes of early childhood development. Children with delayed speech development are more at risk of acquiring other cognitive, social-emotional, and school-related problems. Music therapy appears to facilitate speech development in children, even within a short period of time. The aim of this pilot study is to explore the effects of music therapy in children with delayed speech development. Methods A total of 18 children aged 3.5 to 6 years with delayed speech development took part in this observational study in which music therapy and no treatment were compared to demonstrate effectiveness. Individual music therapy was provided on an outpatient basis. An ABAB reversal design with alternations between music therapy and no treatment with an interval of approximately eight weeks between the blocks was chosen. Before and after each study period, a speech development test, a non-verbal intelligence test for children, and music therapy assessment scales were used to evaluate the speech development of the children. Results Compared to the baseline, we found a positive development in the study group after receiving music therapy. Both phonological capacity and the children's understanding of speech increased under treatment, as well as their cognitive structures, action patterns, and level of intelligence. Throughout the study period, developmental age converged with their biological age. Ratings according to the Nordoff-Robbins scales showed clinically significant changes in the children, namely in the areas of client-therapist relationship and communication. Conclusions This study suggests that music therapy may have a measurable effect on the speech development of children through the treatment's interactions with fundamental aspects of speech development, including the ability to form and maintain relationships and prosodic abilities. Thus, music therapy may provide a basic and supportive therapy for

  19. Effects of music therapy in the treatment of children with delayed speech development - results of a pilot study

    Directory of Open Access Journals (Sweden)

    Linden Ulrike

    2010-07-01

    Full Text Available Abstract Background Language development is one of the most significant processes of early childhood development. Children with delayed speech development are more at risk of acquiring other cognitive, social-emotional, and school-related problems. Music therapy appears to facilitate speech development in children, even within a short period of time. The aim of this pilot study is to explore the effects of music therapy in children with delayed speech development. Methods A total of 18 children aged 3.5 to 6 years with delayed speech development took part in this observational study in which music therapy and no treatment were compared to demonstrate effectiveness. Individual music therapy was provided on an outpatient basis. An ABAB reversal design with alternations between music therapy and no treatment with an interval of approximately eight weeks between the blocks was chosen. Before and after each study period, a speech development test, a non-verbal intelligence test for children, and music therapy assessment scales were used to evaluate the speech development of the children. Results Compared to the baseline, we found a positive development in the study group after receiving music therapy. Both phonological capacity and the children's understanding of speech increased under treatment, as well as their cognitive structures, action patterns, and level of intelligence. Throughout the study period, developmental age converged with their biological age. Ratings according to the Nordoff-Robbins scales showed clinically significant changes in the children, namely in the areas of client-therapist relationship and communication. Conclusions This study suggests that music therapy may have a measurable effect on the speech development of children through the treatment's interactions with fundamental aspects of speech development, including the ability to form and maintain relationships and prosodic abilities. Thus, music therapy may provide a basic

  20. Environmental opportunities questionnaire: development of a measure of the environment supporting early motor development in the first year of life.

    Science.gov (United States)

    Doralp, Samantha; Bartlett, Doreen J

    2013-09-01

    The development and testing of a measure evaluating the quality and variability in the home environment as it relates to the motor development of infants during the first year of life. A sample of 112 boys and 95 girls with a mean age of 7.1 months (SD 1.8) and GA of 39.6 weeks (SD 1.5) participated in the study. The measurement development process was divided into three phases: measurement development (item generation or selection of items from existing measurement tools), pilot testing to determine acceptability and feasibility to parents, and exploratory factor analysis to organize items into meaningful concepts. Test-retest reliability and internal consistency were also determined. The environmental opportunities questionnaire (EOQ) is a feasible 21-item measure comprised of three factors including opportunities in the play space, sensory variety and parental encouragement. Overall, test-retest reliability was 0.92 (CI 0.84-0.96) and the internal consistency is 0.79. The EOQ emphasizes quality of the environment and access to equipment and toys that have the potential to facilitate early motor development. The preliminary analyses reported here suggest more work could be done on the EOQ to strengthen its use for research or clinical purposes; however, it is adequate for use in its current form. Implications for Rehabilitation New and feasible 21-item questionnaire that enables identification of malleable environmental factors that serve as potential points of intervention for children that are not developing typically. Therapeutic tool for use by therapists to inform and guide discussions with caregivers about potential influences of environmental, social and attitudinal factors in their child's early development.

  1. Affordances in the home environment for motor development: Validity and reliability for the use in daycare setting.

    Science.gov (United States)

    Müller, Alessandra Bombarda; Valentini, Nadia Cristina; Bandeira, Paulo Felipe Ribeiro

    2017-05-01

    The range of stimuli provided by physical space, toys and care practices contributes to the motor, cognitive and social development of children. However, assessing the quality of child education environments is a challenge, and can be considered a health promotion initiative. This study investigated the validity of the criterion, content, construct and reliability of the Affordances in the Home Environment for Motor Development - Infant Scale (AHEMD-IS), version 3-18 months, for the use in daycare settings. Content validation was conducted with the participation of seven motor development and health care experts; and, face validity by 20 specialists in health and education. The results indicate the suitability of the adapted AHEMD-IS, evidencing its validity for the daycare setting a potential tool to assess the opportunities that the collective context offers to child development. Copyright © 2017 Elsevier Inc. All rights reserved.

  2. Meta-analyses of cognitive and motor function in youth aged 16 years and younger who subsequently develop schizophrenia.

    Science.gov (United States)

    Dickson, H; Laurens, K R; Cullen, A E; Hodgins, S

    2012-04-01

    Previous reviews have reported cognitive and motor deficits in childhood and adolescence among individuals who later develop schizophrenia. However, these reviews focused exclusively on studies of individuals with affected relatives or on population/birth cohorts, incorporated studies with estimated measures of pre-morbid intelligence, or included investigations that examined symptomatic at-risk participants or participants 18 years or older. Thus, it remains unclear whether cognitive and motor deficits constitute robust antecedents of schizophrenia. Meta-analyses were conducted on published studies that examined cognitive or motor function in youth aged 16 years or younger who later developed schizophrenia or a schizophrenia spectrum disorder (SSD) and those who did not. Twenty-three studies fulfilled the following inclusion criteria: (1) written in English; (2) prospective investigations of birth or genetic high-risk cohorts, or follow-back investigations of population samples; (3) objective measures of cognitive or motor performance at age 16 or younger; (4) results provided for individuals who did and who did not develop schizophrenia/SSD later in life; and (5) sufficient data to calculate effect sizes. Four domains of function were examined: IQ; Motor Function; General Academic Achievement; and Mathematics Achievement. Meta-analyses showed that, by age 16, individuals who subsequently developed schizophrenia/SSD displayed significant deficits in IQ (d=0.51) and motor function (d=0.56), but not in general academic achievement (d=0.25) or mathematics achievement (d=0.21). Subsidiary analysis indicated that the IQ deficit was present by age 13. These results demonstrate that deficits in IQ and motor performance precede the prodrome and the onset of illness.

  3. Delayed development of neural language organization in very preterm born children.

    Science.gov (United States)

    Mürner-Lavanchy, Ines; Steinlin, Maja; Kiefer, Claus; Weisstanner, Christian; Ritter, Barbara Catherine; Perrig, Walter; Everts, Regula

    2014-01-01

    This study investigates neural language organization in very preterm born children compared to control children and examines the relationship between language organization, age, and language performance. Fifty-six preterms and 38 controls (7-12 y) completed a functional magnetic resonance imaging language task. Lateralization and signal change were computed for language-relevant brain regions. Younger preterms showed a bilateral language network whereas older preterms revealed left-sided language organization. No age-related differences in language organization were observed in controls. Results indicate that preterms maintain atypical bilateral language organization longer than term born controls. This might reflect a delay of neural language organization due to very premature birth.

  4. Development of an analogue multiplexed regulation for periodic 1. order delayed processes

    International Nuclear Information System (INIS)

    Amblard, J.C.

    1967-07-01

    The present note deals with the study regulations of the sampled type, for 1. order process with simple delay. In order to obtain a good stability in such regulations, together with acceptable performances, it is interesting to use polynomial type correctors acting directly on the sampled error signals. The active elements of these correctors can be shared by all the channels to be controlled. Furthermore, the determination of the correction parameters results from an optimal study of the system. In the second part is described the construction of a multiplexed regulation for diffusion ovens. (author) [fr

  5. A standardized motor imagery introduction program (MIIP for neuro-rehabilitation: development and evaluation

    Directory of Open Access Journals (Sweden)

    Christine eWondrusch

    2013-08-01

    Full Text Available Background: For patients with central nervous system lesions and sensorimotor impairments a solid motor imagery (MI introduction is crucial to understand and use MI to improve motor performance. The study’s aim was to develop and evaluate a standardized MI group introduction program (MIIP for patients after stroke, multiple sclerosis, Parkinson’s disease, and traumatic brain injury. Methods:Phase 1: Based on literature a MIIP was developed comprising MI theory (definition, type, mode, perspective, planning and MI practice (performance, control. Phase 2: Development of a 27-item self-administered MIIP evaluation questionnaire, assessing MI knowledge self-evaluation of the ability to perform MI and patient satisfaction with the MIIP. Phase 3: Evaluation of MIIP and MI questionnaire by 2 independent MI experts based on predefined criteria and 2 patients using semi-structured interviews.Phase 4: Case series with a pre-post design to evaluate MIIP (3x30minutes using the MI questionnaire, Imaprax, Kinaesthetic and Visual Imagery Questionnaire, and Mental Chronometry. The paired t-test and the Wilcoxon signed-rank test were used to determine significant changes.Results: Data of eleven patients were analysed (5 females; age 62.3±14.1 years. Declarative MI knowledge improved significantly from 5.4±2.2 to 8.8±2.9 (p=0.010. Patients demonstrated good satisfaction with MIIP (mean satisfaction score: 83.2±11.4 %. MI ability remained on a high level but showed no significant change, except a significant decrease in the Kinaesthetic and Visual Imagery Questionnaire score.Conclusion: The presented MIIP seems to be valid and feasible for patients with central nervous system lesions and sensorimotor impairments resulting in improved MI knowledge. MIIP sessions can be held in groups of four or less. MI ability and Mental Chronometry remained unchanged after 3 training sessions.

  6. A standardized motor imagery introduction program (MIIP) for neuro-rehabilitation: development and evaluation.

    Science.gov (United States)

    Wondrusch, C; Schuster-Amft, C

    2013-01-01

    For patients with central nervous system (CNS) lesions and sensorimotor impairments a solid motor imagery (MI) introduction is crucial to understand and use MI to improve motor performance. The study's aim was to develop and evaluate a standardized MI group introduction program (MIIP) for patients after stroke, multiple sclerosis (MS), Parkinson's disease (PD), and traumatic brain injury (TBI). Phase 1: Based on literature a MIIP was developed comprising MI theory (definition, type, mode, perspective, planning) and MI practice (performance, control). Phase 2: Development of a 27-item self-administered MIIP evaluation questionnaire, assessing MI knowledge self-evaluation of the ability to perform MI and patient satisfaction with the MIIP. Phase 3: Evaluation of MIIP and MI questionnaire by 2 independent MI experts based on predefined criteria and 2 patients using semi-structured interviews. Phase 4: Case series with a pre-post design to evaluate MIIP (3 × 30 min) using the MI questionnaire, Imaprax, Kinaesthetic and Visual Imagery Questionnaire, and Mental Chronometry. The paired t-test and the Wilcoxon signed-rank test were used to determine significant changes. Data of eleven patients were analysed (5 females; age 62.3 ± 14.1 years). Declarative MI knowledge improved significantly from 5.4 ± 2.2 to 8.8 ± 2.9 (p = 0.010). Patients demonstrated good satisfaction with MIIP (mean satisfaction score: 83.2 ± 11.4%). MI ability remained on a high level but showed no significant change, except a significant decrease in the Kinaesthetic and Visual Imagery Questionnaire score. The presented MIIP seems to be valid and feasible for patients with CNS lesions and sensorimotor impairments resulting in improved MI knowledge. MIIP sessions can be held in groups of four or less. MI ability and Mental Chronometry remained unchanged after 3 training sessions.

  7. Timing of motor milestones achievement and development of overweight in childhood: a study within the Danish National Birth Cohort.

    Science.gov (United States)

    Schmidt Morgen, C; Andersen, A M N; Due, P; Neelon, S B; Gamborg, M; Sørensen, T I A

    2014-08-01

    Overweight may hinder achievement of gross motor milestones and delayed achievement of milestones may increase the risk of later overweight for reasons involving physical activity and the building of lean body mass. To investigate whether increased birth weight and body mass index (BMI) at 5 months is associated with the achievement of the ability to sit up and walk and whether delayed achievement of these milestones is associated with overweight at age 7 years. We used data from the Danish National Birth Cohort on 25,148 children born between 1998 and 2003. Follow-up took place from 2003 to 2010. Mean age at follow-up was 7.04 years. We used logistic and linear regression analyses. Birth weight and BMI at 5 months were marginally associated with earlier achievement of the ability to sit up and walk (regression coefficients between -0.027 months; [CI -0.042; -0.013] and -0.092 months [CI -0.118; -0.066]). Age in months of sitting and walking were not associated with overweight at age 7 years (ORs between 0.97 [CI 0.95-1.00] and 1.00 [CI 0.96-1.04]). Later achievement of sitting and walking predicted lower BMI at age 7 years (ln-BMI -z-scores between -0.023 [CI -0.029; -0.017] and -0.005 [CI -0.015; 0.005)). All observed associations were of negligible magnitude and we conclude that birth weight or BMI at age 5 months and motor milestones appear largely independent of each other and that timing of achievement of motor milestones seems not to be associated with later overweight or increased BMI. © 2013 The Authors. Pediatric Obesity © 2013 International Association for the Study of Obesity.

  8. Development of a sub-nanometer positioning device: combining a new linear motor with linear motion ball guide ways

    International Nuclear Information System (INIS)

    Otsuka, J; Tanaka, T; Masuda, I

    2010-01-01

    A new type of linear motor described in this note has some advantages compared with conventional motors. The attractive magnetic force between the stator (permanent magnets) and mover (armature) is diminished almost to zero. The efficiency is better because the magnetic flux leakage is very small, the size of motor is smaller and detent (force ripple) is smaller than for conventional motors. Therefore, we think that this motor is greatly suitable for ultra-precision positioning as an actuator. An ultra-precision positioning device using this motor and linear motion ball guide ways is newly developed by making the device very rigid and using a suitable control method. Moreover, the positioning performance is evaluated by a positioning resolution, and deviation and dispersion errors. As a result of repeated step response tests, the positioning resolution is 0.3 nm, with the deviation error and dispersion error (3σ) being sub-nanometer. Consequently, the positioning device achieves sub-nanometer positioning. (technical design note)

  9. Motor cortex hand area and speech: implications for the development of language.

    Science.gov (United States)

    Meister, Ingo Gerrit; Boroojerdi, Babak; Foltys, Henrik; Sparing, Roland; Huber, Walter; Töpper, Rudolf

    2003-01-01

    Recently a growing body of evidence has suggested that a functional link exists between the hand motor area of the language dominant hemisphere and the regions subserving language processing. We examined the excitability of the hand motor area and the leg motor area during reading aloud and during non-verbal oral movements using transcranial magnetic stimulation (TMS). During reading aloud, but not before or afterwards, excitability was increased in the hand motor area of the dominant hemisphere. This reading effect was found to be independent of the duration of speech. No such effect could be found in the contralateral hemisphere. The excitability of the leg area of the motor cortex remained unchanged during reading aloud. The excitability during non-verbal oral movements was slightly increased in both hemispheres. Our results are consistent with previous findings and may indicate a specific functional connection between the hand motor area and the cortical language network.

  10. Space Launch System Base Heating Test: Sub-Scale Rocket Engine/Motor Design, Development & Performance Analysis

    Science.gov (United States)

    Mehta, Manish; Seaford, Mark; Kovarik, Brian; Dufrene, Aaron; Solly, Nathan

    2014-01-01

    ATA-002 Technical Team has successfully designed, developed, tested and assessed the SLS Pathfinder propulsion systems for the Main Base Heating Test Program. Major Outcomes of the Pathfinder Test Program: Reach 90% of full-scale chamber pressure Achieved all engine/motor design parameter requirements Reach steady plume flow behavior in less than 35 msec Steady chamber pressure for 60 to 100 msec during engine/motor operation Similar model engine/motor performance to full-scale SLS system Mitigated nozzle throat and combustor thermal erosion Test data shows good agreement with numerical prediction codes Next phase of the ATA-002 Test Program Design & development of the SLS OML for the Main Base Heating Test Tweak BSRM design to optimize performance Tweak CS-REM design to increase robustness MSFC Aerosciences and CUBRC have the capability to develop sub-scale propulsion systems to meet desired performance requirements for short-duration testing.

  11. Finger-Based Numerical Skills Link Fine Motor Skills to Numerical Development in Preschoolers.

    Science.gov (United States)

    Suggate, Sebastian; Stoeger, Heidrun; Fischer, Ursula

    2017-12-01

    Previous studies investigating the association between fine-motor skills (FMS) and mathematical skills have lacked specificity. In this study, we test whether an FMS link to numerical skills is due to the involvement of finger representations in early mathematics. We gave 81 pre-schoolers (mean age of 4 years, 9 months) a set of FMS measures and numerical tasks with and without a specific finger focus. Additionally, we used receptive vocabulary and chronological age as control measures. FMS linked more closely to finger-based than to nonfinger-based numerical skills even after accounting for the control variables. Moreover, the relationship between FMS and numerical skill was entirely mediated by finger-based numerical skills. We concluded that FMS are closely related to early numerical skill development through finger-based numerical counting that aids the acquisition of mathematical mental representations.

  12. [A delayed motor production of open chains of linear strokes presented visually in static and dynamic modes: a comparison between 9 to 11 years old children and adults].

    Science.gov (United States)

    Antonova, A A; Absatova, K A; Korneev, A A; Kurgansky, A V

    2015-01-01

    The production of drawing movements was studied in 29 right-handed children of 9-to-11 years old. The movements were the sequences of horizontal and vertical linear stokes conjoined at right angle (open polygonal chains) referred to throughout the paper as trajectories. The length of a trajectory varied from 4 to 6. The trajectories were presented visually to a subject in static (linedrawing) and dynamic (moving cursor that leaves no trace) modes. The subjects were asked to draw (copy) a trajectory in response to delayed go-signal (short click) as fast as possible without lifting the pen. The production latency time, the average movement duration along a trajectory segment, and overall number of errors committed by a subject during trajectory production were analyzed. A comparison of children's data with similar data in adults (16 subjects) shows the following. First, a substantial reduction in error rate is observed in the age range between 9 and 11 years old for both static and dynamic modes of trajectory presentation, with children of 11 still committing more error than adults. Second, the averaged movement duration shortens with age while the latency time tends to increase. Third, unlike the adults, the children of 9-11 do not show any difference in latency time between static and dynamic modes of visual presentation of trajectories. The difference in trajectory production between adult and children is attributed to the predominant involvement of on-line programming in children and pre-programming in adults.

  13. De novo alloreactive memory CD8+ T cells develop following allogeneic challenge when CNI immunosuppression is delayed.

    Science.gov (United States)

    Hart-Matyas, M; Gareau, A J; Hirsch, G M; Lee, T D G

    2015-01-01

    Allospecific memory T cells are a recognized threat to the maintenance of solid-organ transplants. Limited information exists regarding the development of alloreactive memory T cells when post-transplant immunosuppression is present. The clinical practice of delaying calcineurin inhibitor (CNI) initiation post-transplant may permit the development of a de novo allospecific memory population. We investigated the development of de novo allospecific memory CD8+ T cells following the introduction of CNI immunosuppression in a murine model using allogeneic cell priming. Recipient mice alloprimed with splenocytes from fully mismatched donors received cyclosporine (CyA), initiated at 0, 2, 6, or 10days post-prime. Splenocytes from recipients were analyzed by flow cytometry or enzyme-linked immunosorbent assay for evidence of memory cell formation. Memory and effector CD8+ T cell development was prevented when CyA was initiated at 0day or 2days post-prime (p0.05). Delaying CyA up to 6days or later post-prime permits the development of functional de novo allospecific memory CD8+ T cells. The development of this potentially detrimental T cell population in patients could be prevented by starting CNI immunosuppression early post-transplant. Copyright © 2014 Elsevier B.V. All rights reserved.

  14. Development and Performance of the 10 kN Hybrid Rocket Motor for the Stratos II Sounding Rocket

    NARCIS (Netherlands)

    Werner, R.M.; Knop, T.R.; Wink, J; Ehlen, J; Huijsman, R; Powell, S; Florea, R.; Wieling, W; Cervone, A.; Zandbergen, B.T.C.

    2016-01-01

    This paper presents the development work of the 10 kN hybrid rocket motor DHX-200 Aurora. The DHX-200 Aurora was developed by Delft Aerospace Rocket Engineering (DARE) to power the Stratos II and Stratos II+ sounding rocket, with the later one being launched in October 2015. Stratos II and Stratos

  15. Factors Affecting Psychosocial and Motor Development in 3-Year-Old Children Who Are Deaf or Hard of Hearing

    Science.gov (United States)

    Leigh, Greg; Ching, Teresa Y. C.; Crowe, Kathryn; Cupples, Linda; Marnane, Vivienne; Seeto, Mark

    2015-01-01

    Previous research has shown an association between children's development of psychosocial and motor skills. This study evaluated the development of these skills in 301 three-year-old deaf and hard of hearing children (M: 37.8 months) and considered a range of possible predictors including gender, birth weight, age at first fitting with hearing…

  16. Development of regenerative peripheral nerve interfaces for motor control of neuroprosthetic devices

    Science.gov (United States)

    Kemp, Stephen W. P.; Urbanchek, Melanie G.; Irwin, Zachary T.; Chestek, Cynthia A.; Cederna, Paul S.

    2017-05-01

    Traumatic peripheral nerve injuries suffered during amputation commonly results in debilitating neuropathic pain in the affected limb. Modern prosthetic technologies allow for intuitive, simultaneous control of multiple degrees of freedom. However, these state-of-the-art devices require separate, independent control signals for each degree of freedom, which is currently not possible. As a result, amputees reject up to 75% of myoelectric devices preferring instead to use body-powered artificial limbs which offer subtle sensory feedback. Without meaningful and intuitive sensory feedback, even the most advanced myoelectric prostheses remain insensate, burdensome, and are associated with enormous cognitive demand and mental fatigue. The ideal prosthetic device is one which is capable of providing intuitive somatosensory feedback essential for interaction with the environment. Critical to the design of such a bioprosthetic device is the development of a reliable biologic interface between human and machine. This ideal patient-prosthetic interface allows for transmission of both afferent somatosensory information and efferent motor signals for a closed-loop feedback system of neural control. Our lab has developed the Regenerative Peripheral Nerve Interface (RPNI) as a biologic nerve interface designed for stable integration of a prosthetic device with transected peripheral nerves in a residual limb. The RPNI is constructed by surgically implanting the distal end of a transected peripheral nerve into an autogenous muscle graft. Animal experiments in our lab have shown recording of motor signals from RPNI's implanted into both rodents and monkeys. Here, we achieve high amplitude EMG signals with a high signal to noise (SNR) ratio.

  17. Development and face validity of a cerebral visual impairment motor questionnaire for children with cerebral palsy.

    Science.gov (United States)

    Salavati, M; Waninge, A; Rameckers, E A A; van der Steen, J; Krijnen, W P; van der Schans, C P; Steenbergen, B

    2017-01-01

    The objectives of this study were (i) to develop two cerebral visual impairment motor questionnaires (CVI-MQ's) for children with cerebral palsy (CP): one for children with Gross Motor Function Classification System (GMFCS) levels I, II and III and one for children with GMFCS levels IV and V; (ii) to describe their face validity and usability; and (iii) to determine their sensitivity and specificity. The initial versions of the two CVI-MQ's were developed based on literature. Subsequently, the Delphi method was used in two groups of experts, one familiar with CVI and one not familiar with CVI, in order to gain consensus about face validity and usability. The sensitivity and specificity of the CVI-MQ's were subsequently assessed in 82 children with CP with (n = 39) and without CVI (n = 43). With the receiver operating curve the cut-off scores were determined to detect possible presence or absence of CVI in children with CP. Both questionnaires showed very good face validity (percentage agreement above 96%) and good usability (percentage agreement 95%) for practical use. The CVI-MQ version for GMFCS levels I, II and III had a sensitivity of 1.00 and specificity of 0.96, with a cut-off score of 12 points or higher, and the version for GMFCS levels IV and V had a sensitivity of 0.97 and a specificity of 0.98, with a cut-off score of eight points or higher. The CVI-MQ is able to identify at-risk children with CP for the probability of having CVI. © 2016 John Wiley & Sons Ltd.

  18. Development of a smart type motor operated valve for nuclear power plants

    Science.gov (United States)

    Kim, Chang-Hwoi; Park, Joo-Hyun; Lee, Dong-young; Koo, In-Soo

    2005-12-01

    In this paper, the design concept of the smart type motor operator valve for nuclear power plant was described. The development objective of the smart valve is to achieve superior accuracy, long-term reliability, and ease of use. In this reasons, developed smart valve has fieldbus communication such as deviceNet and Profibus-DP, auto-tuning PID controller, self-diagnostics, and on-line calibration capabilities. And also, to achieve pressure, temperature, and flow control with internal PID controller, the pressure sensor and transmitter were included in this valve. And, temperature and flow signal acquisition port was prepared. The developed smart valve will be performed equipment qualification test such as environment, EMI/EMC, and vibration in Korea Test Lab. And, the valve performance is tested in a test loop which is located in Seoul National University Lab. To apply nuclear power plant, the software is being developed according to software life cycle. The developed software is verified by independent software V and V team. It is expected that the smart valve can be applied to an existing NPPs for replacing or to a new nuclear power plants. The design and fabrication of smart valve is now being processed.

  19. Goal orientation and conflicts: Motors of change in development projects in health care service.

    Science.gov (United States)

    Elg, Mattias; Kollberg, Beata; Lindmark, Jan; Olsson, Jesper

    2007-01-01

    In this article we present parts of a larger research study, which aims at explaining how a process-oriented innovation unfolds and develops over time in Swedish health care. Through a longitudinal field study of a national and a local development project, we analyze how the flow model--a process-oriented innovation that emphasizes the sequence of activities a patient undertakes through the health care system--has been developed in Swedish health care. We propose to explain how the development projects unfold over time through the use of process theories of organizational development and change. The national project is best understood as a process of evolution from the phase of selection of projects and teleological (goal-oriented, socially constructed development) and dialectic theory (development via conflict of 2 opposing ideas from different organizational entities) through the process in which national ideas face real-world practice. We also propose a synthesis of dialectics and teleological motors for explaining local development. This synthesis proposes that local development teams have a rather broad notion of what it takes to implement the flow model. The team knows the goal, procedures, and activities from a broad perspective. Through a search-and-interact process, in which other organizational entities such as IT consultants, medical units and politicians have a heavy influence, the group sets and implements goals. Details of how to proceed are, however, constructed in the process of acting. This occurs as ideas are developed and tested in real settings. We conclude the article by presenting managerial implications for understanding these process patterns.

  20. Balance maintenance as an acquired motor skill: Delayed gains and robust retention after a single session of training in a virtual environment.

    Science.gov (United States)

    Elion, Orit; Sela, Itamar; Bahat, Yotam; Siev-Ner, Itzhak; Weiss, Patrice L Tamar; Karni, Avi

    2015-06-03

    Does the learning of a balance and stability skill exhibit time-course phases and transfer limitations characteristic of the acquisition and consolidation of voluntary movement sequences? Here we followed the performance of young adults trained in maintaining balance while standing on a moving platform synchronized with a virtual reality road travel scene. The training protocol included eight 3 min long iterations of the road scene. Center of Pressure (CoP) displacements were analyzed for each task iteration within the training session, as well as during tests at 24h, 4 weeks and 12 weeks post-training to test for consolidation phase ("offline") gains and assess retention. In addition, CoP displacements in reaction to external perturbations were assessed before and after the training session and in the 3 subsequent post-training assessments (stability tests). There were significant reductions in CoP displacements as experience accumulated within session, with performance stabilizing by the end of the session. However, CoP displacements were further reduced at 24h post-training (delayed "offline" gains) and these gains were robustly retained. There was no transfer of the practice-related gains to performance in the stability tests. The time-course of learning the balance maintenance task, as well as the limitation on generalizing the gains to untrained conditions, are in line with the results of studies of manual movement skill learning. The current results support the conjecture that a similar repertoire of basic neuronal mechanisms of plasticity may underlay skill (procedural, "how to" knowledge) acquisition and skill memory consolidation in voluntary and balance maintenance tasks. Copyright © 2015 Elsevier B.V. All rights reserved.