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Sample records for del tronco cerebral

  1. Hernias cerebrais intracranianas e lesões secundarias do tronco cerebral

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    João Guidugli Neto

    1976-06-01

    Full Text Available Estudando casos com deslocamento intracraniano de massa encefálica e hemorragia secundária do tronco cerebral o autor assinala lesões ao nível de artérias Os tipos de lesões encontradas sugerem uma etiologia mecânica. São discutidos os demais fatores e o achado de hemorragias venosas e capilares. O deslocamento caudal do tronco cerebral é interpretado como o fator lesivo mais importante.

  2. Potencial evocado auditivo na monitorização de 15 microlaser cirurgias do tronco cerebral

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    Luiz Henrique Mattos Pimenta

    1989-12-01

    Full Text Available Baseados na experiência de 15 casos, os autores salientam a importância do uso sistemático do potencial evocado auditivo do tronco cerebral na monitorização peroperatória do tronco cerebral, área das mais delicadas do cérebro, evitando que o cirurgião seja advertido pelo anestesista de que seu paciente está apresentando bradicardia ou arritmia. Apenas a cirurgia com Laser (acoplado a microscópio permite monitorização contínua, sem interferência de aparelhagem elétrica. Além disso, nos casos relatados, foi verificada a existência de alterações da fisiologia do tronco cerebral quando usados o bipolar ou micro-dissectores, o que não ocorre com o Laser a. CO2.

  3. Tumores do tronco cerebral: estudo anatomopatológico em 35 casos de necrópsia

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    Carmen Lúcia Penteado Lancellotti

    1989-09-01

    Full Text Available Os tumores do tronco cerebral são raros e geralmente tratados sem diagnóstico histopatológico. Sua incidência varia na literatura entre 1,09% e 17,5% dos tumores cerebrais. O objetivo do trabalho foi relatar a casuísti desses tumores em 28500 necrópsias realizadas de 1952 a 1985 no Departamento de Anatomia Patológica da Santa Casa de São Paulo. Enfatizamos os aspectos neuropatológicos, comparamos nossos casos com os de outras séries e salientamos os tumores mais observados nessa região, com a finalidade de procurar contribuir para melhor abordagem terapêutica. Utilizamos alguns dados clínicos e, através do exame anatomopatológico, localizamos o tumor no tronco cerebral sendo o diagnóstico microscópico estabelecido segundo os critérios da Organização Mundial da Saúde. Dos 428 tumores intracranianos observados, 35 estavam localizados no tronco cerebral. Foram aqui incluídos os tumores próprios do tronco cerebral e as metástases e excluídos os tumores que infiltravam o tronco. A maior incidência ocorreu na primeira década e a causa de óbito predominante foi edema cerebral. A localização preferencial foi a ponte e o tumor mais freqüente foi o glioblas-tomia multiforme (19 casos. As metástases ficaram em segundo lugar na freqüência (9 casos, na maioria dos casos de origem pulmonar. Apesar de alguns autores se posicionarem contra a biópsia de tumor nessa região, baseando-se no alto risco cirúrgico, discordamos dessa opinião, pois acreditamos que, frente ao diagnóstico de glioma, será importante a caracterização ou não de malignidade. Ainda, não devemos deixar de considerar os diagnósticos diferenciais de processo expansivo no tronco. Enfim, com o diagnóstico anatomopatológico de glioma ou de uma das possibilidades aventadas, o procedimento terapêutico poderá ser mais adequado.

  4. INFLUÊNCIA DA EQUOTERAPIA NO CONTROLE CERVICAL E DE TRONCO EM UMA CRIANÇA COM PARALISIA CEREBRAL

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    Alessanda Gregório

    2013-01-01

    Full Text Available A equoterapia é um método fisioterápico que se baseia na utilização do trote do cavalo como meio de tratamento em pacientes com sequelas sensoriais e motoras decorrentes de distúrbios neurológicos. Por tratar-se de um estudo de caso, o objetivo deste trabalho é avaliar a influência da equoterapia no controle cervical e de tronco em uma criança com paralisia cerebral (PC. A criança participante possui dois anos de idade e diagnóstico médico de tetraparesia espastica. Foram realizadas duas avaliações utilizando a escala de Gross Motor Function Measure (GMFM antes e após todo o período das sessões de equoterapia. Esse método de avaliação consiste em 88 itens divididos em cinco dimensões: A, deitar e rolar; B, sentar; C, engatinhar e ajoelhar; D, em pé; e E, correndo e pulando. Utilizaram-se as dimensões A e B da escala GMFM no presente estudo. A equoterapia foi desenvolvida durante dez sessões de trinta minutos, utilizando montarias distintas. Observou-se que o controle cervical e o controle de tronco estavam presentes ao término do tratamento, que é comprovado com o aumento de 19,5% e 7,7% para as dimensões A e B da escala GMFM, respectivamente. A equoterapia apresentou grande eficiência no ganho do controle cervical e de tronco da criança com PC.

  5. Activación de los músculos del tronco durante situaciones que requieren de la estabilización del raquis. Estudio de caso único

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    Francisco J. Vera-García

    2007-03-01

    Full Text Available El objetivo de este estudio fue analizar la intensidad de la contracción y la coordinación de 14 músculos del tronco y del hombro de un sujeto durante la recepción y el lanzamiento de un balón medicinal (acción pliométrica, una acción de empuje en bipedestación (press de pecho horizontal con polea y el uso del Bodyblade® (barra flexible cuya oscilación somete al cuerpo a vibraciones y desequilibrios continuos. Asimismo, con el objeto de facilitar la discusión en relación con la estabilización activa del raquis, se registró la respuesta de los músculos referidos durante la aplicación controlada sobre el tronco de cargas y descargas desequilibrantes. Nuestros resultados indican que la activación de los músculos del tronco es importante tanto para estabilizar el raquis ante perturbaciones y desequilibrios bruscos, como para la ejecución de acciones donde los miembros superiores manejan objetos. En este sentido, la coactivación de los músculos del tronco fue necesaria para estabilizar el raquis ante las oscilaciones del Bodyblade® y ante las fuerzas de reacción producidas al empujar una carga pesada en postura erecta. Asimismo, la recepción y lanzamiento inmediato del balón medicinal es una actividad relativamente compleja que requiere de la acción coordinada de los músculos del tronco y de las extremidades

  6. Test de campo para valorar la resistencia de los músculos del tronco

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    Casto Juan-Recio

    2014-09-01

    Full Text Available El Biering-Sorensen test (BST, el Side Bridge test (SBT y el Ito test (IT son tres de los test de campo más utilizados para medir la resistencia de los músculos del tronco. El objetivo de este estudio fue analizar la fiabilidad absoluta y relativa de los test referidos, así como valorar el efecto de la antropometría de los participantes en el rendimiento en las pruebas. En el estudio participaron 27 jóvenes varones (23,5 ± 4,0 años y físicamente activos. Los participantes realizaron dos sesiones de registro en las que ejecutaron los tres test (recuperación de 8 min entre pruebas y donde se midieron diversas variables antropométricas. La fiabilidad relativa fue buena, con ICC mayores de 0.80 en todos los test, pero no así la fiabilidad absoluta, con SEM que oscilaron entre el 13,36 % en el BST y el 19,89 % en el IT. El IT mostró una correlación negativa con la masa (r= – ,475; p= ,014 y el diámetro bileocrestal (r = – ,404; p = ,040 y el SBT una correlación negativa con la masa (r = –,610; p = ,001, el diámetro bileocrestal (r = –,546; p = ,004, el diámetro biacromial (r= - ,456; p = ,019 y el índice acromioiliaco (r= –,413; p = ,036. Los datos de fiabilidad ab-soluta cuestionan la utilidad de estas pruebas en programas de entrenamiento donde los participantes tienen poco margen de mejora. Además, si se realizan comparaciones entre sujetos es importante tener en cuenta sus diferencias antropométricas, ya que durante la ejecución de los test el cuerpo se utiliza como instrumento de medida.

  7. Células-tronco

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    Elizabeth Obino Cirne-Lima

    2008-01-01

    Considerando a origem de obtenção, as células-tronco podem ser classificadas como células-tronco embrionárias (ES) ou como células-tronco adultas. Mas, se a plasticidade for considerada, as células-tronco podem ser classificadas como células totipotentes, quando as células-tronco preservam a capacidade de dar origem a um novo indivíduo completo. Quando as células-tronco perdem esta capacidade, passam a ser classificadas como células-tronco pluripotentes, que podem dar origem a praticamente to...

  8. Angioplastia del tronco de la arteria coronaria izquierda no protegido en pacientes con alto riesgo quirúrgico

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    Victor Mauro

    2008-01-01

    Full Text Available IntroducciónEl tratamiento de elección de la enfermedad del tronco de la coronaria izquierda (TCI es la cirugía de revascularización miocárdica (CRM. Un número creciente de pacientes presenta comorbilidades y/o inestabilidad clínica que condicionan un alto riesgo quirúrgico.ObjetivosEvaluar los resultados de la angioplastia (ATC del TCI no protegido en pacientes con alto riesgo para CRM (EUROSCORE = 6.Material y métodosDe 59 pacientes con ATC de TCI no protegido se excluyeron 8 con infarto agudo de miocardio (IAM en shock cardiogénico y 12 sin características de alto riesgo; de los restantes pacientes de alto riesgo fueron objeto de este estudio los 32 tratados con stents convencionales.Se comparó la mortalidad hospitalaria predicha por EUROSCORE logístico con la observada, así como la incidencia de complicaciones mayores y su evolución alejada.ResultadosLa mediana de edad fue de 76,5 años, el 41% tenía 80 años o más, el 22% eran mujeres, el 28% diabéticos, el 56% tenía disfunción ventricular moderada a grave, el 31% insuficiencia renal crónica, el 50% vasculopatía periférica, el 53% angina refractaria, el 22% IAM reciente, el 28% procedimientos de emergencia y la mediana de EUROSCORE fue de 10,5 puntos.El 41% de los pacientes presentaban compromiso del TCI distal. El éxito angiográfico fue del 94%. Se utilizaron inhibidores IIb/IIIa en el 47%, cutting balloon en el 28%, Rotablator® en el 3% y balón de contrapulsación en el 31%. En todos se implantó un stent y en el 50% se trataron otras obstrucciones.La mortalidad hospitalaria fue del 3,1% (intervalo de confianza del 95% 0,2%-14,5%, p = 0,003, en tanto que la predicha era del 23,8%. Ningún paciente presentó déficit neurológico, IAM transmural ni requirió diálisis. Un paciente debió ser sometido a CRM electiva por fracaso del procedimiento.La mediana de seguimiento fue de 15,5 meses, período en el que se registraron 6 muertes (2 cardiovasculares y 4

  9. Tratamiento de la compresión del tronco de la arteria coronaria izquierda en pacientes con hipertensión pulmonar

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    María L. Talavera

    2011-10-01

    Full Text Available La angina de pecho es un síntoma frecuente en pacientes con hipertensión pulmonar (HP de cualquier etiología. Aunque su fisiopatología no está aclarada, las causas propuestas son: la isquemia subendocárdica por aumento del estrés parietal del ventrículo derecho, la dilatación de la arteria pulmonar por incrementos transitorios de la presión pulmonar y la compresión extrínseca del tronco de la arteria coronaria izquierda (TCI por la arteria pulmonar (AP dilatada. Se presentan tres casos que muestran la relación entre la angina de pecho y la compresión del TCI en pacientes con HP asociada a cardiopatías congénitas, tratados mediante implante de stent coronario.

  10. Estudio de la vía auditiva central por medio de las respuestas evocadas auditivas del tronco encefálico (ABR, en niños con retraso en el lenguaje

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    Manuel Gallardo

    2003-03-01

    Full Text Available Objetivo: Determinar la integridad funcional de la vía auditiva en el tronco encefálico a través de las respuestas evocadas auditivas del tronco encefálico (ABR en niños con retardo en el lenguaje sin patología en oído medio y sistema nervioso central y sin factores de riesgo de hipoacusia neonatal. Diseño: Estudio retrospectivo transversal. Lugar: Servicios de otorrinolaringología del Centro Médico Naval y del Hospital Central de la Fuerza Aérea del Perú. Material y Métodos: Se analizó el ABR realizado en los últimos diez años a niños con retardo en el lenguaje, que incluyó 48 niños, 28 varones y 20 mujeres, con edades entre 1 y 11 años. Se evaluó los tiempos de latencia y la morfología de las ondas I, II, III, IV y V del ABR. Resultados: Se encontró las latencias dentro de lo normal para cada edad. En 77% de los pacientes hubo distorsión morfológica y/o hipovoltaje de las ondas, más frecuentemente (58% en las ondas I y II, correspondientes al nervio auditivo y núcleos cocleares en el tronco encefálico. Conclusiones: Los resultados sugieren que existe trastorno en la sincronización neural de la vía auditiva en el VIII par y en el tronco encefálico en 77% de los pacientes evaluados, lo cual afectaría el procesamiento auditivo central.

  11. Avaliação isocinética da musculatura envolvida na flexão e extensão do tronco: efeito do método Pilates® Evaluación isocinética de la musculatura comprendida en la flexion y en la extensión del tronco: efecto del método Pilates® Isokinetic evaluation of the musculature involved in trunk flexion and extension: Pilates© method effect

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    Inélia Ester Garcia Garcia Kolyniak

    2004-12-01

    Full Text Available O desequilíbrio entre a função dos músculos extensores e flexores do tronco é um forte indício para o desenvolvimento de distúrbios da coluna lombar. O objetivo do presente trabalho foi avaliar o efeito do método Pilates® sobre a função de extensores e flexores do tronco. Para tanto, foram selecionadas 20 pessoas (16 mulheres com idade média de 34,06 ± 7,21; quatro homens com idade média de 33,5 ± 6,68 anos com habilidade para executar os exercícios do nível intermediário-avançado, que completaram 25 sessões durante 12 semanas. Os voluntários foram submetidos ao teste isocinético de avaliação da flexão e extensão do tronco no início e ao final do período de treinamento. A função dos extensores do tronco apresentou aumento em todos parâmetros analisados (pico de torque _ 25%, p = 0,0004; trabalho total - 28%, p = 0,0002; potência - 30%, p = 0,0002; quantidade total de trabalho - 21%, p = 0,002 em relação ao período pré-treinamento. Com relação aos músculos flexores, foi detectado discreto aumento para trabalho total (10%, p = 0,0003 e para quantidade total de trabalho (10%, p = 0,002. Analisando a razão flexor:extensor, em todos os parâmetros, foi detectada redução significativa em relação aos índices obtidos no pré-treinamento (pico de torque - 24%, p = 0,0001; trabalho total - 23%, p = 0,002; potência - 25%, p = 0,01; quantidade total de trabalho - 14%, p = 0,04. O método Pilates® (nível intermediário-avançado mostrou-se uma eficiente ferramenta para o fortalecimento da musculatura extensora do tronco, atenuando o desequilíbrio entre a função dos músculos envolvidos na extensão e flexão do tronco.El desequilibrio entre la función de los músculos extensores y flexores del tronco es un fuerte indicio para el desarrollo de disturbios de la columna lumbar. El objetivo del presente trabajo fue avaluar el efecto del método Pilates® sobre la función de los extensores y flexores del tronco

  12. Cirugía del tronco común con y sin circulación extracorpórea

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    Remedios Ríos Barrera

    2006-01-01

    Conclusiones: Los resultados en ambos grupos han sido similares, por lo que, en la actualidad, la existencia de estenosis del TC no condiciona la técnica de revascularización miocárdica quirúrgica con o sin CEC, quedando su elección a criterio del cirujano.

  13. Avaliação dos achados ao exame dos potenciais evocados do tronco cerebral em indivíduos com síndrome de West Evaluation of the brainstem evoked potentials in West syndrome

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    Alfredo Lopes Pereira Filho

    2004-01-01

    Full Text Available A síndrome de West é um tipo de espasmo infantil caracterizado por encefalopatia epiléptica associado a espasmos em flexão e deficiência mental de instalação no primeiro ano de vida e de etiologia incerta. Acredita-se ser determinada por diferentes fatores etiológicos como infeção intrauterina, esclerose tuberosa, asfixia perinatal ou afecções pós-natais. FORMA DE ESTUDO: Observacional coorte com corte transversal. MATERIAL E MÉTODO: No presente estudo dez pacientes com Síndrome de West foram submetidos ao exame de Potencial Evocado de Tronco Cerebral (BERA para avaliar o envolvimento do tronco cerebral e das vias auditivas a este nível. RESULTADO: Os achados anormais ao BERA incluem alteração na morfologia das curvas com reprodutibilidade apenas de onda I e II, (caso 7, aumento do intervalo interpico da onda I-V (casos 1, 2 e 9, aumento da proporção de amplitude da onda I/V (caso 8 e alteração do limiar eletrofisiológico (caso 7. Tais achados ao BERA sugerem que a disfunção do sistema nervoso resulte principalmente da hipogênese ou degeneração das células nervosas, em parte como resultado da dismielinização. CONCLUSÃO: Os autores recomendam o uso de estudos eletrofisiológicos para avaliar a disfunção do sistema nervoso central no paciente com suspeita de espasmo infantil.The West syndrome is a pediatric disease that involves muscular spasm, mental deficiency and epileptic encephalopathy. This disease tends to be noticed in the first year of life and has no etiology known. It is believed to be caused by different etiology factors as uterine infection, tuberous sclerosis, perinatal asphyxia, or post-born diseases. STUDY DESIGN: Observacional cohort with transversal cut. MATERIAL AND METHOD: In this study, ten West Syndrome patients were submitted to Auditory Brainstem Response (ABR to evaluate the involvement of the hearing system. RESULTS: The abnormal results consisted in morphological alterations (case 7

  14. Paralisia Facial Periférica por comprometimento do tronco cerebral: A propósito de um caso clínico Peripheral Facial Paralisys of brainstem origin: A clinical case description

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    Paulo R. Lazarini

    Full Text Available É apresentado um caso clínico de paciente portador de paralisia facial periférica com comprometimento de toda a hemiface direita. Durante a investigação clínica, esperava-se que o comprometimento topográfico do nervo facial se desse a partir de sua emergência na ponte. Após exames de imagem, evidenciou-se lesão expansiva no tronco cerebral. Deste modo, a classificação de paralisia facial como periférica ou central não atende a este caso. O uso de uma classificação utilizando os núcleos do nervo facial como referência pode ser mais adequado na investigação clínica da paralisia facial.It is presented a clinical case of a patient with a peripheral facial paralysis with hemifacial compromise. During the clinical investigation it was expected that the topographic compromise of the facial nerve would arise out of the emergence of the nerve from the pons. After some image examinations, an expansive brain trunk lesion was evidenced. Thus, the classification of facial paralysis - either peripheral or central - is not applicable to this case. The use of a classification having the facial nerve nucleus as reference could be more adequate in the clinical investigation of the paralysis.

  15. Troncos de Salix Humboldtiana en depósitos aluviales del Holoceno tardío, río Sauce Grande (Provincia de Buenos Aires

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    Jorge Rabassa

    1991-01-01

    Full Text Available El presente trabajo tiene como objetivo la presentación de este hallazgo, discutir la estratigrafía y la cronología de los sedimentos portadores e intentar la reconstrucción de las características paleoambientales. Para ello, fueron realizados perfiles estratigráficos en las localidades estudiadas, muestreo de las unidades reconocidas, estudio palinológico en doce niveles distintos, muestreo de materiales orgánicos para fechado radiocarbónico y recolección de troncos para su estudio xilològico.

  16. Cirurgia do arco aórtico com perfusão cerebral bilateral pelo isolamento do tronco braquiocefálico e da artéria carótida esquerda Aortic arch surgery with bilateral cerebral perfusion by isolation of brachiocephalic trunk and left carotid artery

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    Valdo José Carreira

    2008-03-01

    Full Text Available OBJETIVO: Estudar os resultados da técnica descrita por Carreira et al. com utilização de perfusão cerebral seletiva bilateral (PCSAB pelo isolamento do tronco braquiocefálico e artéria carótida esquerda. MÉTODOS: Quinze pacientes foram operados consecutivamente entre de junho de 2005 e setembro de 2007. Os dados foram analisados por programa informatizado Epi Info e significância estatística com p0,05. CONCLUSÃO: A técnica de PCSAB é reprodutível e apresenta resultados semelhantes aos da literatura mundial. A excelente evolução neurológica e o fácil controle de sangramentos nas linhas de sutura podem ter contribuído com os resultados obtidos.OBJECTIVE: To evaluate the results of a technique described by Carreira et al. using bilateral antegrade selective cerebral perfusion by isolating the brachiocephalic trunk and the left carotid artery. METHODS: Fifteen patients were operated between June 2005 and September 2007. Data analysis were performed using Epi Info and statistical significance was set at p0.05. CONCLUSION: The technique of bilateral selective cerebral perfusion described by Carreira et al. can be performed by others and presents similar results to the international literature. The excellent neurological outcome and easy bleeding control on surgical sutures lines are the major advantages of this new procedure.

  17. Variation of water potential and trunk diameter answer as sensitivity to the water availability in table grapes Variación del potencial hídrico y del diámetro del tronco como respuestas sensibles a la disponibilidad de agua en uva de mesa

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    Claudio Silva-Contreras

    2012-12-01

    Full Text Available Variation in trunk diameter (TDV has been proposed as an indicator of the water status of grape vines, with apparently contradictory results. In Vitis vinifera L. var. Crimson Seedless we evaluated the water potential (Ψ, an indicator normally used to determine the water status of grapes, and TDV, comparing two irrigation treatments which restored 100% or 50% of the ETc, to compare the sensitivity of these two indicators to a decrease in soil water. Two evaluation periods of 23 d each were used, the first during the exponential growth phase and the second in the post-veraison period, when the trunk stops growing. In both periods TDV showed coefficients of variation greater than 25%, compared to the 7-10% recorded for water potential. However, during the first measuring period (82-105 d after bud break the TDV of the treatment with water deficit decreased by more than 30%, while water potential only decreased from 6-12%. In the second measurement period (112-155 d after bud break in which fruit growth is predominant, the control showed TDV values 100% greater than those of the treatment with water deficit, while the differences in water potential were between 10% and 13%. These results demonstrate the sensitivity of the continuous variation of the trunk diameter and the utility of TDV as a criterion for irrigation control, taking into consideration the development stage of the vines.La variación del diámetro del tronco (TDV ha sido propuesta como un indicador del estado hídrico de las plantas, con resultados aparentemente contradictorios. En Vitis vinifera L. var. Crimson Seedless se evaluó la respuesta del potencial hídrico (Ψ, indicador normalmente utilizado para definir el estado hídrico de las plantas y TDV, frente a dos tratamientos de riego, 100% y 50% de reposición de la evapotranspiración del cultivo (ETc, para determinar si la TDV es más apropiada que el Ψ para la evaluación del estrés hídrico en vides. Se consideraron dos

  18. O BERA como instrumento de avaliação funcional do tronco cerebral em cirurgias com hipotermia profunda e parada circulatória total The ABR as a tool in the evaluation of brainstem function in surgeries with deep hypothermia and total cardiac arrest

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    Luiz Carlos Alves de Sousa

    2003-10-01

    Full Text Available OBJETIVO: Monitoramento do tronco cerebral através da análise dos traçados do BERA em cirurgia cardíaca com hipotermia profunda e parada circulatória total (PCT, registrando a recuperação funcional (eletrofisiológica do tronco cerebral. FORMA DE ESTUDO: Coorte Longitudinal. MATERIAL E MÉTODO: Foram estudados o comportamento do traçado do BERA de 8 pacientes submetidos a cirurgia cardíaca com hipotermia profunda e PCT para correção de aneurisma de aorta torácica. Etapas: resfriamento corporal até 18ºC C; PCT por até 60 minutos; reaquecimento. Registros do BERA: 35ºC, 32ºC, 26ºC, 18ºC, 27ºC, 35ºC. RESULTADOS: Os traçados iniciais (35ºC se apresentavam normais. Aos 26ºC há o desaparecimento de todas as ondas. Aos 18ºC o traçado do BERA mostrava um padrão isoelétrico. Aos 27ºC, recuperação das ondas I, III e V. A partir de 35ºC as latências das ondas retornam ao normal. CONCLUSÃO: O BERA constitui-se em competente instrumento de monitoramento da integridade funcional do tronco cerebral em cirurgia cardíaca com hipotermia profunda e PCT. As ondas desaparecem no período de resfriamento corporal, atingem um padrão isoelétrico a 18ºC, e reaparecem durante o reaquecimento. No final do procedimento, os médicos anestesistas não dispõem de exame clínico fidedigno para acessar a integridade funcional do tronco cerebral, devido ao uso de drogas depressoras do SNC. O reaparecimento das ondas do BERA é o parâmetro proposto para este fim. A manutenção do padrão isoelétrico após o reaquecimento corporal sugere grave comprometimento funcional do tronco cerebral.AIM: The authors propose the use of ABR as an instrument for the detection of brainstem dysfunction in the trans- and post-operatory period of surgeries with total circulatory arrest (TCA and deep hypothermia for correction of aneurysms of the thoracic aorta. STUDY DESIGN: Longitudinal Cohort. MATERIAL AND METHOD: Eight adult patients that underwent

  19. Encefalitis del tallo cerebral y mielitis por Listeria monocytogenes

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    Aracelly Castro

    2013-09-01

    Full Text Available La romboencefalitis por Listeria monocytogenes es una presentación poco común de la listeriosis del sistema nervioso central; sin embargo, es la presentación más común en personas inmunocompetentes. Aun más rara es la combinación de romboencefalitis con mielitis causada por L. monocytogenes; no obstante, en este artículo se reporta un caso de encefalitis del tallo y mielitis grave en un paciente sin compromiso del sistema inmunitario. Se presenta un paciente de 21 años de edad, sin deficiencias del sistema inmunitario, que consumió productos lácteos no pasteurizados y, posteriormente, presentó un cuadro de cefalea, vómito, deterioro de su estado general y, finalmente, alteración del estado de conciencia y muerte. Consultó al Instituto Neurológico de Colombia y se hizo diagnóstico de encefalitis del tallo y mielitis por L. monocytogenes. Se discuten las diferencias entre el caso presentado y los reportados en la literatura científica. Ante un paciente con signos de compromiso del tallo cerebral, de posible origen infeccioso, es prudente iniciar tratamiento antibiótico para L. monocytogenes y, en caso de poca respuesta, escalar rápidamente en dicho tratamiento. También lo es extender el estudio radiológico hacia la columna vertebral, con el fin de descartar compromiso de la médula espinal.   doi: http://dx.doi.org/10.7705/biomedica.v33i3.1482

  20. Hemorragia de tronco cerebral após remoção cirúrgica de cisto aracnóide da fissura silviana: Relato de caso Brainstem hemorrhage after surgical removal of arachnoid cyst of the sylvian fissure: case report

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    Guilherme Borges

    1995-12-01

    Full Text Available Os autores relatam um caso de hemorragia de tronco cerebral após craniotomia para ressecção de grande cisto aracnóide de fissura silviana esquerda. A sintomatologia inicial pré-operatória incluía sinais de hipertensão intracraniana e a tomografia computadorizada mostrava desvio de linha média. Diversos fatores são discutidos para explicar o sangramento parenquimatoso pós-operatório: edema cerebral, diminuição do retorno venoso e de fluxo sanguíneo no lado comprimido. Entretanto a fisiopatologia da hemorragia parenquimatosa em casos como o relatado permanece obscura. Uma abordagem cirúrgica mais cautelosa é proposta nesses pacientes com de hipertensão intracraniana.The authors report a case of a hemorrhage of the brainstem after craniotomy for resection of a huge arachnoid cyst of the sylvian fissure on the left hemisphere. The previous simptomatology included clinical signs of increased intracranial pressure, and the computerized tomography showed midline shift. Some factors may contribute to brain hemorrhage post-operatively: cerebral edema, ipsilateral changes in the venous reflux and blood perfusion, although the physiopathology remains obscure. A more careful approach is suggested in such cases with intracranial hypertension.

  1. Avaliação radiográfica da descompensação do tronco após artrodese seletiva torácica em portadores de escoliose idiopática do adolescente King II (Lenke B e C Evaluación radiográfica de la descompensación del tronco después de una artrodesis selectiva torácica en portadores de escoliosis idiopática del adolescente King II (Lenke B y C Radiographic evaluation of trunk decompensation with selective thoracic arthrodesis in patients with adolescent idiopathic scoliosis type King II (Lenke B e C

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    Osmar Avanzi

    2009-12-01

    Full Text Available OBJETIVO: avaliar a incidência de descompensação radiográfica do tronco após a artrodese seletiva torácica com instrumental de 3º geração na escoliose idiopática do adolescente (EIA King II (Lenke B e C após acompanhamento mínimo de um ano. MÉTODOS: foram avaliadas retrospectivamente as radiografias pré-operatórias, pós-operatórias imediatas e do último acompanhamento de 22 pacientes tratadas no período de 1993 a 2007. Observou-se a porcentagem de correção da curva torácica e lombar pelo método de Cobb, e o balanço coronal do tronco do início e do final do acompanhamento foi avaliado pelos critérios da Scoliosis Research Society. RESULTADOS: após correção média da curva torácica de 56 ± 11% e da lombar de 49 ±13%, verificamos descompensação coronal imediata em seis pacientes (27,20%. Após acompanhamento médio de 65 meses, quatro pacientes (18,18% estavam com o tronco descompensado. Em apenas um paciente foi necessária extensão da artrodese, incluindo a curva lombar. CONCLUSÕES: a descompensação grave do tronco com necessidade de segundo procedimento para artrodese lombar foi complicação não frequente nesta série de casos.OBJETIVO: evaluar la incidencia de descompensación radiográfica del tronco después de una artrodesis selectiva torácica con instrumental de tercera generación en la escoliosis idiopática del adolescente (EIA King II (Lenke B y C, después de un acompañamiento mínimo de un año. MÉTODOS: fueron evaluados retrospectivamente las radiografías preoperatorias, postoperatorias inmediatas y del último acompañamiento de 22 pacientes tratados en el periodo de 1993 a 2007. Se observó un porcentaje de correlación de la curva torácica y lumbar, por el método de Cobb, y el balance coronal del tronco al inicio y al final del acompañamiento por los criterios de la Scoliosis Research Society. RESULTADOS: después de la corrección promedio de la curva torácica de 56±11% y de la

  2. Resultados inmediatos y a los 5 años de la cirugía de pacientes portadores de lesión del tronco de la coronaria izquierda

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    Rodolfo A. Ahuad Guerrero

    2008-01-01

    Full Text Available AntecedentesLa cirugía de revascularización miocárdica se considera hasta el momento el mejor tratamiento para los pacientes portadores de enfermedad del tronco de la coronaria izquierda (TCI; pese a ello existen pocos datos locales que comuniquen los resultados de esta cirugía.ObjetivosDescribir los resultados inmediatos y a los 5 años de una serie de cirugías coronarias en pacientes con lesiones del TCI.Material y métodosEn el período 2003-2007 se estudiaron 174 cirugías coronarias del TCI realizadas en forma consecutiva en tres servicios quirúrgicos asociados. Se analizaron los resultados quirúrgicos a los 30 días y en el seguimiento hasta 5 años, en los que se tuvieron en cuenta la mortalidad de causa cardiovascular y por otras causas, los eventos cardiovasculares mayores, la necesidad de nueva revascularización y la supervivencia libre de síntomas. Las curvas se compararon con la supervivencia esperada para el mismo grupo de edad y sexo.ResultadosEl 90,8% de los pacientes tuvieron lesiones múltiples. La mortalidad a los 30 días fue del 4,0%, similar a la esperada según el EuroSCORE (6,4%, OR = 0,62, IC 95% 0,21-1,78; p = 0,333, y los eventos cardiovasculares mayores incluyeron 2,9% de infarto y 1,7% de accidente cerebrovascular (ACV. El seguimiento fue de 506 pacientes-años (12 a 60 meses e involucró al 91% de los pacientes. Al considerar la mortalidad cardiovascular, la supervivencia a los 5 años fue del 83,7%, similar a la esperada en la población general. La supervivencia en el mismo plazo descendió al 77,6% cuando se computaron todas las causas de muerte (p = 0,436. La supervivencia a los 5 años libre de angina y de nueva revascularización fue del 72,2% y del 88,1%, respectivamente.ConclusionesEn este estudio observacional de pacientes operados con lesión del TCI se demostró una mortalidad quirúrgica algo inferior a la calculada con el EuroSCORE y una tasa de ACV e infarto de entre el 1,7% y el 2,9%. El

  3. Aneurisma del tronco principal de la arteria coronaria izquierda Descripción de un caso clínico y revisión de tema

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    Julio C. Rodríguez, MD

    2010-05-01

    Full Text Available El aneurisma arterial coronario constituye una entidad rara en la población; su incidencia varía entre 1,5% y 5%, siendo más frecuente en hombres. Existe escasa bibliografía acerca de esta patología a pesar de que su estudio se remonta a finales del siglo XVIII. La arteria que se afecta con mayor frecuencia es la coronaria derecha, aproximadamente en 40% de los casos. La dificultad al momento del diagnóstico clínico radica en que inicialmente el enfoque está dirigido a confirmar y tratar de manera oportuna el síndrome coronario agudo que con insistencia constituye la manifestación inicial con que cursan este tipo de pacientes; por ello el diagnóstico necesariamente requiere ayudas imaginológicas e intervencionistas, o ambas. Hay muchas causas que puedan producir aneurismas en la circulación coronaria, la más común de ellas es la aterosclerosisseguida por trastornos congénitos, enfermedades del tejido conectivo, vasculitis y consumo de cocaína entre otros. Recientemente se han publicado innovadores estudios respecto a la fisiopatología y los avances en terapéutica farmacológica e intervencionista, aunque el tratamiento debe enfocarse en los factores de riesgo, las patologías y las manifestaciones clínicas que presente el paciente.

  4. Thrombotic obstruction of the central venous catheter in patients undergoing hematopoietic stem cell transplantation Obstrucción trombótica del catéter venoso central en pacientes sometidos al trasplante de células-tronco hematopoyéticas Obstrução trombótica do cateter venoso central em pacientes submetidos ao transplante de células-tronco hematopoéticas

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    Kátia Michelli Bertoldi Arone

    2012-08-01

    Full Text Available This is an integrative literature review with the aim of summarizing the prevention measures and treatment of thrombotic obstruction of long-term semi-implanted central venous catheters, in patients undergoing hematopoietic stem cell transplantation. The sample consisted of seven studies, being two randomized controlled clinical trials, three cohort studies and two case series. Regarding the prevention measures, one single study demonstrated effectiveness, which was a cohort study on the oral use of warfarin. In relation to the treatment measures, three studies evidenced effectiveness, one highlighted the efficacy of streptokinase or urokinase, one demonstrated the benefit of using low-molecular-weight heparin and the other treated the obstruction with heparin or urokinase. Catheter patency research shows a restricted evolution that does not follow the evolution of transplantations, mainly regarding nursing care.Se trata de una revisión integradora de la literatura con objeto de sintetizar las medidas de prevención y tratamiento de obstrucción trombótica del catéter venosos central de larga permanencia y semi-implantado, en pacientes sometidos al trasplante de células-tronco hematopoyéticas. La muestra abarcó a siete estudios: dos ensayos clínicos controlados aleatorizados, tres estudios de cohorte y dos series de casos. Respecto a las medidas de prevención, fue identificado un único estudio efectivo, uno cohorte sobre el uso de la warfarina oral. Sobre las medidas de tratamiento, tres estudios evidenciaron efectividad, uno apuntó la eficacia de la estreptoquinasa o uroquinasa, otro mostró beneficio del uso de heparina de bajo peso molecular y otro trató la obstrucción con heparina o uroquinasa. Se observa que la evolución de la investigación sobre la permeabilidad del catéter fue limitada, no acompañando la evolución del trasplante, principalmente respecto a los cuidados de enfermería.Trata-se de revisão integrativa da

  5. ESTUDIO DEL EFECTO DE LA CRANEOACUPUNTURA EN PACIENTES CON ENFERMEDAD VASCULAR CEREBRAL. (EVC)

    OpenAIRE

    PEREZ BRAVO, MIGUEL

    2009-01-01

    LA ENFERMEDAD VASCULAR CEREBRAL (EVC) EN MEXICO ES UN IMPORTANTE PROBLEMA DE SALUD PUBLICA, ES LA TERCERA CAUSA DE MUERTE Y LA SEGUNDA EN PRODUCIR INCAPACIDAD NEUROLOGICA. EL OBJETIVO DE ESTE ESTUDIO FUE EVALUAR EL EFECTO DE LA CRANEOACUPUNTURA EN PACIENTES CON ENFERMEDAD VASCULAR CEREBRAL (ZHONG FENG). EL PRESENTE ES UN ESTUDIO EXPERIMENTAL, PROSPECTIVO Y LONGITUDINAL, REALIZADO EN EL HOSPITAL DEL ISSSTE DE LA CIUDAD DE PUEBLA, A UN GRUPO DE 11 PACIENTES DE AMBOS SEXOS, CON...

  6. Uso rutinario del balón de contra-pulsación aórtica preoperatorio en pacientes con enfermedad del tronco común izquierdo sometidos a cirugía de revascularización coronaria Routine use of preoperative intra-aortic balloon pump counterpulsation (IABP implantation in patients with left main coronary artery disease undergoing coronary revascularization surgery

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    Andrés Fernández

    2008-08-01

    Full Text Available Generalidades: la enfermedad del tronco común izquierdo como único criterio para la colocación de balón de contra-pulsación aórtica, es una indicación cuya evidencia se limita a la recomendación de expertos y, por lo tanto, se requieren estudios que puedan aportar mayor nivel de evidencia al respecto. Por este motivo, en nuestra institución se desarrolló un estudio que evaluó la experiencia del uso de balón de contra-pulsación aórtica preoperatorio, en pacientes sometidos a cirugía de revascularización cardiaca electiva, con enfermedad del tronco común izquierdo. Objetivo: describir la letalidad, el tiempo de estancia y el porcentaje de infecciones y sepsis en la unidad de cuidados intensivos, así como el tiempo de ventilación mecánica, en los pacientes sometidos a cirugía de revascularización coronaria electiva con y sin el uso preoperatorio de balón de contra pulsación aórtica. Métodos: estudio descriptivo retrospectivo, que se llevó a cabo en la Clínica Cardiovascular Santa María, con los pacientes que se sometieron a revascularización coronaria quirúrgica electiva acompañados o no de balón de contra-pulsación aórtica preoperatorio entre 1999 y 2003, y en el que se observó el comportamiento post-operatorio de los pacientes con enfermedad severa del tronco común izquierdo (entendida como estenosis mayor de 50% sometidos a dicha intervención. Resultados: se analizaron en total 79 pacientes sometidos a revascularización quirúrgica electiva, a 46 de los cuales se les implantó balón preoperatorio y a 33 se les practicó intervención quirúrgica sin balón. El promedio de edad fue de 62 años. El 67,4% de los pacientes tenía 60 años o más. Las principales patologías previas a la cirugía fueron hipertensión arterial (67% e infarto agudo del miocardio antiguo, (59%. 87% de los pacientes con balón y 45,5% de aquellos sin éste, tenían angina severa (clase III antes de la cirugía. En la unidad de

  7. Anestesia en el tronco arterioso común

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    Lincoln de la Parte Pérez

    2003-04-01

    Full Text Available El tronco arterioso es una anomalía congénita del corazón poco frecuente, que se asocia con una alta mortalidad. El 50 % de los pacientes fallece antes de los 3 meses de edad y el 80 % antes del año. La causa más frecuente de muerte es el fallo cardíaco agudo. Presentamos una experiencia en 2 lactantes operados en el Cardiocentro del Hospital Pediátrico Universitario "William Soler", durante el año 2001: una niña de 7 meses de edad, desnutrida, con un tronco común tipo II, hipertensión pulmonar y síndrome de DiGeorge, el segundo paciente era un lactante de 3 meses de edad, con un tronco común tipo I. Se utilizó fentanyl en la inducción y el mantenimiento de la anestesia. La temperatura recta se bajó a 25 °C y los tiempos de circulación extracorpórea fueron de 100 y 121 min y el de pinzamiento aórtico de 30 y 31 min. Se utilizó apoyo farmacológico con dobutrex en dosis bajas. Se emplearon fentanyl, vasodilatadores en infusión continua e hiperventilación, como medidas para evitar la crisis de hipertensión pulmonar. Los enfermos evolucionaron satisfactoriamente durante todo el transoperatorio.The truncus arteriosus is a rare congenital abnormality that is associated with high mortality. 50 % of the patients died before being 3 months old and 80 % before the first year. The most frequent cause of death is acute heart failure. The cases of 3 infants operated on at the Heart Center of William Soler Pediatric Teaching Hospital during 2001 are presented: a seven-old month malnourished girl with a type II common truncus, pulmonary hypertension and DiGiorgio's syndrome, and a 3-month-old female infant with type I common truncus. Fentanyl was used in the induction and maintenance of anesthesia. The straight temperature was lowered to 25 °C, whereas the times of extracorporeal circulation were 100 and 121 min and those of the aortic clamping were 30 and 31 min. Low doses of dobutrex were administered as pharmacological support

  8. 297. Resultados de la sustitución parcial del arco aórtico con perfusión del tronco braquiocefálico sin parada circulatoria

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    J.M. González Santos

    2012-04-01

    Conclusiones: La sustitución parcial del arco es factible sin necesidad de hacer PCHP. Esta técnica acorta los tiempos quirúrgicos y disminuye sus complicaciones, especialmente el daño neurológico y el sangrado postoperatorio.

  9. Papel de la plasticidad cerebral en las alteraciones del neurodesarrollo: autismo y retraso mental

    OpenAIRE

    Miranda García, Rubén

    2014-01-01

    La plasticidad cerebral es la propiedad que permite al cerebro adaptarse a las condiciones cambiantes del ambiente y de la experiencia, y es el mecanismo que permite su readaptación o reparación ante lesiones. Tal flexibilidad del cerebro puede expresarse tanto a nivel celular, incluyendo procesos de neurogénesis, como o a nivel sináptico, implicando cambios en la estructura y función de las conexiones neuronales. Numerosos trastornos del neurodesarrollo, inducidos por distintas mutaciones ge...

  10. Resultados del tratamiento quirúrgico de los aneurismas del complejo cerebral anterior-arteria comunicante anterior

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    Armando Alemán Rivera

    2001-06-01

    Full Text Available Se realiza un estudio de 30 pacientes con aneurismas localizados en el complejo de la arteria cerebral anterior-arteria comunicante anterior (ACoA, operados en el Servicio de Neurocirugía del Hospital Universitario "Arnaldo Milián Castro", durante un período de 7 años. Se analizan variables tales como edad, sexo, estado neurológico preoperatorio, momento quirúrgico, complicaciones y estado al egreso. La mortalidad general fue del 10 %The authors carried out a study in 30 patients with aneurysms located in the anterior communicating artery-anterior cerebral complex (ACA-ACC, that were operated on at the Neurosurgery Service of "Arnaldo Milián Castro" Teaching Hospital, during a period of 7 years. Variables such as age, sex, preoperative neurologic state, surgical moment, complications and status on discharge were analyzed. General mortality was 10 %

  11. Sistema cerebral del placer y de la drogodependencia

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    Rafael A. Ulloque

    1999-12-01

    Full Text Available Hace cuatro décadas se describió un circuito neurona1 que sería el substrato neuroanatómico y neurobioquimico del placer, la recompensa y la drogodependencia. Algunos animales de experimentación son capaces de autoestimularse eléctricamente o de autoadministrarse sustancias de abuso en las áreas de este sistema de una manera compulsiva, produciéndose manifestaciones que se interpretan como conducta placentera. En esta situación, los animales son capaces de abandonar totalmente otras actividades placenteras como la alimentación y el sexo. El núcleo accumbens, el hipocampo, la corteza prefrontal y la amígdala son los núcleos o áreas cerebrales más importantes de este circuito; el núcleo accumbens (y su fisiología es el centro crítico de la iniciación y del mantenimiento del refuerzo de la conducta y del abuso de drogas. Allí llegan aferencias de estructuras corticales como la corteza prefrontal y el hipocampo, y de otras como la amígdala y el área ventral del tegmento. El núcleo accumbens proyecta al pálido ventral y a los núcleos motores mesencefálicos desde los cuales salen eferencias a la médula espinal. Esta sería la vía de difusión de estímulos nacidos en el núcleo accumbens, los cuales están involucrados en la actividad sicomotriz. Se enfatizará especialmente la neurotransmisión del núcleo accumbens y del hipocampo. Se piensa que la dopamina y algunos neurotransmisores aminoacidérgicos son importantes en la regulación sináptica de este sistema. Existe consenso sobre el papel relevante de la dopamina en este circuito de recompensa, neurotrasmisor que está muy involucrado en los condicionamientos y en la drogodependencia. Sin embargo, no debe dejarse de lado la función de los otros neurotransmisores. Esta revisión destaca principalmente el papel que juegan el GABA, el glutamato y el aspartato y, muy recientemente, la participación del oxido nítrico.

  12. Evaluación diagnóstica del niño con parálisis cerebral Diagnostic evaluation of cerebral palsy in the child

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    Gerardo R. Robaina Castellanos

    2007-06-01

    Full Text Available La parálisis cerebral es la discapacidad física más frecuente de la niñez. A pesar de ello, a menudo se presentan dificultades en su diagnóstico. Se realiza una actualización de la evaluación diagnóstica del niño con parálisis cerebral. El diagnóstico de esta discapacidad es fundamentalmente clínico, lo cual comprende una anamnesia detallada de los factores de riesgo y del desarrollo psicomotor del niño, además del examen neuromotor. Resulta necesaria la aplicación de una serie de instrumentos para determinar el grado de limitación funcional y las alteraciones asociadas. Dentro de los exámenes complementarios, los exámenes neuroimaginológicos son los más importantes en la búsqueda de causas probables y la determinación del momento de la lesión cerebral. Otros exámenes (electroencefalograma, estudios genéticos, metabólicos y de coagulación tienen indicaciones específicas. Para la evaluación integral de estos niños se requiere del concurso de múltiples especialidades médicas, psicopedagógicas y sociales.Cerebral palsy is the most frequent physical disability in childhood. In spite of this, it is often difficult to diagnose it. An updating on the diagnostic evaluation of the child with cerebral palsy was provided in this paper. The diagnosis is essentially clinical, which comprises a detailed description of risk factors and the psychomotor development of the affected child in addition to a neuromotor exam. The application of a series of instruments to determine the level of functional limitation and associated disturbances is required. Among the supplementary tests, neuroimaging is the most important to search for likely causes and to determine the moment of cerebral injure. Other tests (electroencephalogram, genetic, metabolic and coagulation studies, etc have specific indications. For a comprehensive assessment of these children, the participation of many medical, psychoeducational and social specialties is

  13. Reconstrucción de defectos amplios en tronco mediante colgajo de perforante en piedra clave

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    J. Aguilera-Sáez

    Full Text Available El colgajo en piedra clave (Keystone Perforator Island Flap KPIF, es un colgajo local fasciocutáneo en isla que no requiere identificación de perforantes, descrito por Behan en 2003, que permite el cierre en un único acto quirúrgico tanto del defecto como de la zona dadora sin precisar, generalmente, autoinjerto cutáneo. Nuestro objetivo es el mostrar la utilidad de este colgajo para la cobertura de defectos amplios en tronco. De los más de 120 casos realizados en nuestro Servicio con esta técnica sin tener en cuenta la localización del problema entre abril de 2011 y abril de 2013, presentamos 5 casos que, tras resección quirúrgica por diferentes etiologías, fueron los que presentaron defectos de cobertura de mayor tamaño en tronco (entre 10 y 25 cm de diámetro máximo que fueron solventados satisfactoriamente mediante el KPIF. En todos obtuvimos un cierre directo tanto de la zona del defecto como de la zona dadora, sin complicaciones durante el acto quirúrgico ni en el postoperatorio, con resultados estéticos óptimos, sin deformidades significativas ni alteraciones funcionales. Creemos que el KPIF es un colgajo óptimo para la cobertura de defectos amplios en el tronco ya que permite cubrir el defecto y hacer un cierre primario de la zona dadora generando poca morbilidad, con un buen resultado estético, con un corto tiempo quirúrgico y con un bajo coste.

  14. Utilidad de la ecocardiografía en la detección de la insuficiencia cardiaca en un adulto joven con síndrome de origen anómalo de la arteria coronaria izquierda del tronco de la arteria pulmonar y válvula mitral asimétrica similar al paracaídas

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    Luis Cordero

    2018-03-01

    Full Text Available Resumen: Objetivo: describir un caso de un paciente joven con insuficiencia cardiaca, secundaria a dos malformaciones cardiacas infrecuentes, síndrome de ALCAPA y válvula mitral asimétrica, parecida al paracaídas, resaltando la utilidad de la ecocardiografía. Métodos: se analiza el caso a la luz de la literatura médica. Conclusiones: El origen anómalo de la arteria coronaria izquierda del tronco de la arteria pulmonar y la válvula mitral asimétrica parecida al paracaídas, son malformaciones raras, asociadas a insuficiencia mitral severa e insuficiencia cardiaca. No se encontraron reportes en la literatura acerca de la coexistencia de las dos patologías en un paciente. Abstract: Objective: To describe a case of a young adult with heart failure, secondary to two rare cardiac malformations, anomalous left coronary artery from the pulmonary artery (ALCAPA syndrome and parachute-like asymmetric mitral valve, highlighting the use of echocardiography. Material and methods: A case is analysed along with a search in the medical literature. Conclusions: The anomalous origin of left coronary artery from the pulmonary artery and parachute-like asymmetric mitral valve are rare malformations associated with severe mitral insufficiency and heart failure. No reports were found in the literature as regards the existence of these two diseases in a patient. Palabras clave: Insuficiencia cardiaca, Insuficiencia mitral, Coronaria izquierda, Cardiopatía congénita, Keywords: Heart failure, Mitral insufficiency, Left coronary artery, Congenital heartdisease

  15. Anatomía funcional del cuerpo estriado y la corteza cerebral: su relación con el movimiento

    OpenAIRE

    Buffone, Gabriel Darío; Dalto, Carlos

    2013-01-01

    El objetivo de la siguiente ponencia es revalorizar y reconocer aquellos aspectos anatómicos y funcionales de algunos elementos del sistema nervioso imprescindibles para el correcto funcionamiento del cuerpo humano, tanto en los movimientos deportivos, como en la variedad infinita de los actos motores resumidos en las contracciones musculares. Ante los diferentes rangos articulares posibles y las determinadas acciones musculares específicas, la corteza cerebral y el cuerpo estriado partici...

  16. Clonagem e células-tronco

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    Mayana Zatz

    2004-08-01

    Full Text Available APESAR do muito que se tem discutido, ainda existe muita confusão em relação aos conceitos de clonagem (reprodutiva e terapêutica , células-tronco ( embrionárias e não embrionárias e terapia celular bem como isso pode afetar as nossas vidas. Portanto a proposta desse artigo é o de tentar definir esses conceitos e expressar a minha posição sobre aspectos éticos não só como cientista mas também como representante de inúmeras famílias que vêem nessa nova tecnologia uma esperança futura de cura para inúmeras doenças neurodegenerativas , muitas vezes letais ou gravemente incapacitantes.ALTHOUGH concepts such as human cloning (reproductive and therapeutic, stem cells (embryonic and non-embryonic , and stem cell therapy and how these issues may affect our lives have been extensively discussed, there is still a lot of misunders-tanding. Therefore the aim of this article is to try to better explain these definitions and express my personal opinion on ethical aspects not only as a scientist but also as a representative of inumerous families who hope that this technology might represent in the future a treatment for many neurodegenerative disorders often lethal or severely disabling.

  17. Efecto de la pregabalina sobre la expresión de Fos en el tronco del encéfalo y la médula espinal en dos modelos de dolor neuropático

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    Villanueva Pérez, Vicente Luis

    2012-01-01

    En las últimas décadas, se han producido avances muy significativos en la búsqueda y hallazgo de nuevas estrategias terapéuticas contra el dolor. Esto ha sido posible gracias, en gran medida, al mayor conocimiento de los mecanismos subyacentes al dolor. Particularmente sustanciales han sido los datos obtenidos acerca del sustrato anatómico de la transmisión dolorosa y de su modulación endógena. En base a estos datos de carácter anatómico se ha ido clasificando el dolor en diferentes tipos: el...

  18. Cerebral physiology and preservation during cardiac arrest Fisiología y preservación cerebral durante el paro cardíaco: vulnerabilidad del cerebro

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    Luis M. Gómez

    1991-03-01

    Full Text Available

    Cerebral physiology during cardiac arrest is discussed with particular Interest on selective neuronal damage. Previous concepts on brain tolerance to hypoxia are analyzed and new information about brain function prognosis after cardiac arrest is presented. Therapeutic alternatives for brain preservation are discussed with emphasis on the lack of effectiveness of barbiturates, the results of research with other drugs and the future role that blockers of excitatory neurotransmission may have as elements of cerebral preservation.

    Se hace una aproximación a la fisiología cerebral durante el paro cardíaco, destacando el concepto de darlo neuronal selectivo. Se presentan elementos que permiten modificar concepciones antiguas sobre la tolerancia del cerebro a la hipoxia severa. Además, se hace un nuevo planteamiento sobre el pronóstico cerebral luego de un paro cardíaco y se esbozan las alternativas terapéuticas utilizadas hasta la fecha para la preservación cerebral. Se hace énfasis en la inefectividad de los barbitúricos, en la investigación sobre la terapia con otras drogas y en el futuro abierto hacia los bloqueadores de los neurotransmisores excitadores, como elementos terapéuticos para la preservación cerebral.

  19. Síndromes del hemisferio no dominante Syndrome of cerebral non-dominant hemisphere

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    Newra Rotta

    2007-01-01

    Full Text Available En este trabajo de revisión se discute lo que entendemos de las funciones hemisféricas y se abordan los principales hallazgos que forman parte del síndrome del hemisferio cerebral no dominante, que en la mayor parte de los casos es el derecho, con énfasis en las alteraciones de la sustancia blanca o sea de las fibras comisurales, de asociación y de proyección. Los diferentes aspectos de los síndromes tienen relación con la etiología, localización, extensión y etapa del desarrollo en que el daño ocurrió. Se observan: hemiplejía izquierda; alteración de la prosodia, así como alteraciones en la comunicación no verbal; percepción visuo-espacial; organización, secuenciación de actividades e interacción social. Estos comportamientos se observan también en trastornos del desarrollo, tales como disturbio de déficit de atención/hiperactividad, y síndrome de Asperger. Con el objetivo de destacar cuáles son los hallazgos más frecuentes y más persistentes en niños con lesión adquirida en el hemisferio derecho, presentamos siete casos de accidente vascular isquémico. Todos los pacientes fueron controlados por más de dos años y se les realizó examen neurológico, examen neurológico evolutivo y evaluación psicológica. Con el seguimiento de los siete casos fue posible observar que las alteraciones motoras son menos severas y menos definitivas que las alteraciones cognitivas, afectivas y conductuales.In this review the meaning of cerebral hemispheric function is discussed with special emphasis in non-dominant cerebral hemisphere and particularly in the lesion of commissural, association, projection of white matter fibers. Clinical characteristics depend on etiology, localization, extension and particularly the period of brain development. The following are common findings in these patients: left hemiplegia, abnormal prosody and non verbal communication, anomalies visiospatial perception, organization, and social interaction

  20. Pseudo-aneurisma post-traumático de tronco de arteria coronaria izquierda

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    Melina M. Gallo

    2011-08-01

    Full Text Available El pseudo-aneurisma de arteria coronaria es extremadamente raro. Su historia natural es poco conocida y su tratamiento discutido. Se presenta el caso de un paciente con pseudo-aneurisma de tronco de la coronaria izquierda e infarto antero-apical del ventrículo izquierdo cinco años después de un paro cardíaco secundario a un traumatismo no penetrante de tórax. Se consideró entonces que la lesión no era pasible de corrección percutánea o quirúrgica por lo que se optó por tratamiento médico conservador. Una angiografía coronaria por tomografía computarizada multicorte realizada 10 años después del evento inicial mostró ausencia de progresión de la lesión.

  1. Evaluación neurofuncional del tallo cerebral Parte II: Reflejo mandibular = Neurofunctional evaluation of brain stem. II. Mandibular reflex

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    Leon Sarmiento, Fidias E.

    2011-09-01

    Full Text Available El reflejo mandibular o maseterino posee conexiones nerviosas únicas, diferentes de las exhi­bidas por otros reflejos monosinápticos humanos, y permite evaluar, de forma fácil y eficien­te, el tallo cerebral por medio de la estimulación mecánica, eléctrica o magnética. Diversos estudios han demostrado la participación en este reflejo de las interneuronas del tallo cerebral y su modulación por estructuras supraespinales, que hacen parte fundamental de su integra­ción motora. El reflejo mandibular es útil para evaluar la afectación trigémino-trigeminal en polineuropatías como la diabetes, neuromiopatías como la esclerosis múltiple y en pacientes con trastornos del movimiento, con o sin disfunción oromandibular. La evaluación neuro­funcional de este reflejo craneofacial ayuda a identificar la integración sensorimotora del tallo cerebral y las posibles alteraciones de estas vías reflejas, debidas a anormalidades del sistema nervioso central o del periférico. Su apropiada ejecución e interpretación, clínica y neurológica, permite aplicar de manera más personalizada diversos protocolos de neurorre­habilitación, con el fin de ayudar a mejorar la calidad de vida de los individuos con afectación de estas vías neurales.

  2. RARE TRIPLE ANATOMICAL VARIATION OF THE CEREBRAL ARTERIAL CIRCLE; Rara triple variación del círculo arterial cerebral.

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    Joaquín García Pisón

    2017-04-01

    Full Text Available Se reporta la rara asociación de un aneurisma de arteria trigeminal persistente lateral derecha (Tipo II de Saltzman, aplasia del segmento pre-comunicante de ambas arterias cerebrales posteriores y la presencia de arterias cerebrales posteriores fetales en forma bilateral, en una mujer de 64 años que consultó de diplopía y parálisis del nervio abducens derecho, probablemente debida a compresión del nervio en el espacio latero-celar. Se realizó con éxito la embolización endovascular con coils, sin complicaciones inmediatas. Los hallazgos de CT, RM y angiografía son presentados. Aunque cada una de estas variaciones son infrecuentes en forma individual, la combinación de las mismas no ha sido reportada en la literatura hasta nuestro conocimiento, siendo de enorme importancia en el manejo diagnóstico y terapéutico de pacientes con stroke de mecanismo embolico, así como para la planificación de procedimientos endovasculares diagnósticos y terapéuticos. We report the rare association of an aneurysm of a lateral right persistent trigeminal artery (Saltzman type II, bilateral aplasia of the pre-communicating segment of both posterior cerebral arteries and bilateral fetal posterior cerebral arteries, in a 64 years old woman who suffered from progressive diplopia and right abducens nerve palsy, most likely due to nerve compression in the latero-cellar space. Successful endovascular coils embolization of the aneurysm was performed, with no immediate complications. CT, MR and angiographic findings are presented. Although infrequent as single variations, the association of these three arterial variations has not been reported in literature to our knowledge, having special importance in the diagnostic workup and therapeutic procedures in a patient with an embolic stroke, as well as in the planification of intracranial endovascular diagnostic and therapeutic procedures.

  3. Isquemia cerebral focal transitoria en rata: caracterización y utilidad del modelo de la sutura intraluminal en el estudio de estrategias neuroprotectoras

    OpenAIRE

    Pérez Asensio, Fernando Jesús

    2005-01-01

    RESUMEN Los accidentes cerebrovasculares agudos (ictus cerebrales) son trastornos neurológicos originados por la disminución brusca del aporte sanguíneo cerebral (isquemia cerebral). La incidencia del ictus en España es de unos 200 casos por cada 100.000 habitantes, lo que le sitúa como la segunda causa de muerte, la primera de invalidez permanente y segunda de demencia. A excepción de la aplicación de la terapia trombolítica, actualmente no existe otro tratamiento eficaz del ictus en c...

  4. Autoayuda cerebral y nuevas gramáticas del bienestar. Cuidar el cerebro para una vida saludable

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    María Jimena Mantilla

    2017-03-01

    Full Text Available En este artículo utilizo el caso de la bibliografía de “autoayuda cerebral” para analizar la organización y combinación de las definiciones neurocientíficas sobre el cerebro en torno a una gramática del bienestar personal. A partir del análisis de un corpus de publicaciones de autoayuda cerebral, describo los modos en que se construye una narrativa cerebralista de la conducta y de las emociones y cómo ésta se articula con una propuesta de cambio personal. El análisis ilumina cómo la vulgarización del discurso neurocientífico provée recursos narrativos para lidiar y dotar de sentido a las experiencias vitales.

  5. ESTUDIO COMPARATIVO DEL EFECTO DE CRANEO-ACUPUNTURA VS ACUPUNTURA CORPORAL, EN PACIENTES CON SECUELAS DE ENFERMEDAD VASCULAR CEREBRAL EN EL HOSPITAL REGIONAL DEL INSTITUTO DE SEGURIDAD SOCIAL AL SERVICIO DE LOS TRABAJADORES DEL ESTADO DE PUEBLA

    OpenAIRE

    MENDEZ MENDEZ, NAZARIO CELSO

    2011-01-01

    ESTUDIO COMPARATIVO DEL EFECTO DE LA CRANEOACUPUNTURA VS ACUPUNTURA CORPORAL, EN PACIENTES CON SECUELAS DE ENFERMEDAD VASCULAR CEREBRAL EN EL HOSPITAL REGIONAL DEL INSTITUTO DE SEGURIDAD SOCIAL AL SERVICIO DE LOS TRABAJADORES DEL ESTADO DE PUEBLA. LAS SECUELAS DE EVC SON UN PROBLEMA DE SALUD PUBLICA, CON MAYOR FRECUENCIA DE LA ISQUEMIA 81.25 POR CIENTO POR CIENTO Y EN SEGUNDO LUGAR LA HEMORRÁGICA CON EL 18.75 POR CIENTO, EL SEXO FEMENINO ES LA MAS FRECUENTE Y LA EDAD MAS AFECTADA ES DE LO...

  6. Efectos de la comida sobre variables antropométricas y de grasa de tronco y visceral por bioimpedancia

    OpenAIRE

    Diego-Acosta, Ángel Mario; Fernández-Vázquez, R; García-Vega, MM; García-Lavigne, JA; Martínez-Blanco, J; Rodríguez-Linares, MV; Ramos-Gil, R; Alvero-Cruz, Jose Ramon

    2014-01-01

    Los efectos de la comida y la bebida sobre las mediciones masa grasa (MG) derivadas por bioimpedancia eléctrica (BIA) tienen efectos que pueden modificar las estimaciones de MG Y masa libre de grasa. El objetivo del trabajo fue determinar si existen diferencias en el perímetro abdominal máximo (PAbM), diámetro sagital abdominal (DSA) como indicadores de obesidad central y en las variables de grasa de tronco y visceral estimadas por BIA. Universidad de Málaga. Campus de Excelencia Internaci...

  7. Atividade eletromiográfica dos músculos extensores do tronco durante exercícios de estabilização lumbar do método Pilates

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    G.A. Paz

    2014-06-01

    Conclusión: Por lo tanto, los ejercicios anteriores se pueden realizar buscando mejorar la activación de los músculos del tronco y la estabilidad de la columna vertebral. Asimismo, los resultados encontrados en el estudio actual pueden ser una referencia para seleccionar los ejercicios durante los programas de entrenamiento para los músculos de la espalda lumbar.

  8. Relación entre la potencia muscular de extremidades inferiores y tronco con la velocidad de salida de la bola en el swing de drive en golf

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    Lorena Torres Ronda

    2010-09-01

    Full Text Available A pesar del interés emergente en el acondicionamiento físico en el golf, se han llevado a cabo pocos estudios para valorar la relación entre la potencia mecánica y el rendimiento en golf. El objetivo de este estudio fue valorar si existía una correlación entre la velocidad de salida de la bola del swing de drive y la potencia muscular de extremidades inferiores y tronco, en un grupo de 8 golfistas (16,8 ± 1,4 años; 2,2 ± 1,8 Handicap; 63,1 ± 6,4 kg.; 172,7 ± 7,5 cm. El test incluyó mediciones de la velocidad de salida de la bola y tests de potencia mecánica (prensa de piernas horizontal, press de banca y rotaciones de tronco. Los resultados de este estudio indican que existe una correlación significativa entre la velocidad de salida de la bola y la potencia piernas (prensa de piernas horizontal: r2=,933; p=,000 y del tronco (press de banca: r2 = 0,66; p = ,014. La prensa de piernas se mostró como el predictor más representativo para la velocidad de salida de la bola (r2 = 0,934; p = ,000.

  9. Células-tronco em odontologia Stem cells in Dentistry

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    Ana Prates Soares

    2007-02-01

    Full Text Available INTRODUÇÃO: existe um grande interesse no desenvolvimento de técnicas para a manipulação de células-tronco, no intuito de instituirem-se tratamentos restauradores de tecidos e órgãos. Para que a bioengenharia seja eficaz, faz-se necessária a presença de três fatores: as próprias células-tronco, uma matriz extracelular e fatores de crescimento. Existem inúmeros fatores de crescimento envolvidos no desenvolvimento do órgão dentário. Por isso pesquisadores ainda não foram capazes de formar um órgão completo, embora existam diversos estudos evidenciando a formação de esmalte e dentina a partir de células-tronco isoladas da polpa dentária. Recentemente, também foram isoladas células-tronco da polpa dos dentes decíduos. Sabe-se que estas células são altamente proliferativas, sendo de grande importância para o cirurgião-dentista o conhecimento do seu comportamento biológico e técnicas de obtenção. OBJETIVO: este estudo teve como objetivo realizar uma revisão de literatura acerca das atuais tendências das pesquisas com células-tronco na Odontologia, além de discorrer sobre os fatores implicados para o sucesso na utilização prática dessas células.INTRODUCTION: there is great interest in developing techniques for manipulation of stem cells for the use in restoring organs and tissues. The effectiveness of bioengineering is based on the existence of stem cells, an extra cellular matrix and growth factors. Innumerous growth factors are involved in the development of dental organs, and this complexity of factors makes it extremely difficult to grow a complete organ, even though there are multiple essays reporting the formation of enamel and dentin from isolated stem cell, originating from dental pulp tissues. More recently, deciduous teeth have been used to extract stem cells from their pulp tissues. We know that these cells are highly proliferate. The recognition of the biological behavior of these cells and

  10. Aneurismas del complejo arteria cerebral anterior / arteria comunicante anterior: Resultados del tratamiento quirúrgico Aneurysms of the anterior cerebral artery-anterior communicating artery complex: Results of the surgical treatment

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    Justo L González González

    2006-03-01

    Full Text Available Los aneurismas del complejo arteria cerebral anterior-arteria comunicante anterior figuran entre los más frecuentes de localización intracraneal y, debido a su variabilidad anatómica y características hemodinámicas, constituyen un reto especial para cualquier esfuerzo terapéutico. Con el objetivo de caracterizarlos y evaluar los resultados del tratamiento quirúrgico de estas lesiones, se estudian los pacientes operados en el Servicio de Neurocirugía del Hospital Clinicoquirúrgico «Hermanos Ameijeiras», entre enero de 1983 y agosto de 1998. Se observó que el 71,1 % de la muestra egresó en excelente estado; el 13,44 %, con secuelas mínimas; el 3,48 %, con secuelas graves y que la mortalidad fue del 11,53 %. Se concluye que estos aneurismas son más frecuentes en el sexo masculino, en la cuarta y quinta décadas de la vida (media de 39,9 años y que el tamaño crítico de ruptura se ubica mayoritariamente entre 6 mm y 11 mm. De igual forma se observó que la edad, el tamaño sacular, el vasoespasmo y la ruptura transoperatoria influyen sobre los resultados y que la influencia de estas dos últimas complicaciones es muy fuerte. El infarto cerebral isquémico fue la causa de muerte más frecuente

  11. Study of the association degree between cerebral magnetic resonance signal and the transcranial sonography Estudio del grado de asociación entre la señal de resonancia magnética cerebral y la ecografía transcraneal Estudi del grau d'associació entre el senya de ressonancia magnètica cerebral i l'ecografia transcranial

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    Carrascosa Morales, Rafael

    2012-01-01

    El coregistre d'una imatge d'ecografia transcraneal amb un volum de ressonància magnètica cerebral i estudi del grau d'associació entre elles. Projecte el·laborat amb Transmural Biotech SL English: The study tries to achieve a multimodal registration between a transcranial sonography (TCS) and a cerebral magnetic resonance volume. After the registration stage, a statistical analysis of each brain matter (white matter, gray matter and cerebrospinal fluid) was performed to demonstrate the...

  12. Discinesias y la agresividad del paciente subnormal, refractarias al tratamiento, pueden aliviarse con la estimulación cerebral profunda.

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    Jaime Weisner Durán

    2007-06-01

    La estimulación cerebral profunda, iniciada por el celebérrimo José M.R. Delgado3, en 1952 (Horgan, 2005, es muy ventajosa, no provoca sino mínima destrucción porque la lesión introductora del microelectrodo es también mínima, es reversible, todo el instrumento foráneo se puede extraer, la estimulación provista es ajustable y el microelectrodo es implantado estereotáxicamente (con enorme exactitud o precisión en el núcleo deficiente, el cual esta conectado a un neuro-estimulador graduador que provee la estimulación eléctrica deseada a uno de los núcleos cerebrales profundos, unilateral o bilateralmente...

  13. ANGIOPLASTIA PERCUTÁNEA CON STENT EN EL TRONCO PRINCIPAL DE LA ARTERIA CORONARIA IZQUIERDA / Percutaneous angioplasty with stent in the left main coronary artery

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    Javier Almeida Gómez

    2012-10-01

    Full Text Available ResumenIntroducción y objetivos: La afectación significativa del tronco común izquierdo, es la más letal de las presentaciones de la enfermedad arterial coronaria. El tratamiento de elección, es la cirugía de derivación aorto-coronaria. En varios estudios multicéntricos, se sugiere la posibilidad de tratar la enfermedad de tronco mediante el intervencionismo coronario percutáneo con implantación de prótesis endoluminal o stent. El objetivo de esta investigación fue caracterizar la angioplastia percutánea con stent en el tronco principal de la arteria coronaria izquierda. Método: Se realizó un estudio observacional, descriptivo y transversal en 21 pacientes con angioplastia percutánea con stent en el tronco principal de la arteria coronaria izquierda, realizadas en el laboratorio de Hemodinámica y Cardiología Intervencionista del Hospital "Hermanos Ameijeiras", entre enero 2010 y julio 2011. Resultados: No existió diferencia significativa en el sexo. Predominó el grupo de edad entre 50-64 años (47,6 % y el color de la piel blanca (76,19 %. El factor de riesgo cardiovascular más encontrado fue la HTA (85,71 %, seguido de dislipidemia (47,61 %. El diagnóstico más observado fue la angina de esfuerzo estable, 14 casos (66,66 %. La lesión en el cuerpo del tronco (12 pacientes, 57,1 %, fue la más encontrada, seguida de la ostial (8 casos. El tipo de stent más utilizado fue el liberador de fármacos (61,9 %, y solamente 4 pacientes presentaban troncos protegidos quirúrgicamente. Conclusiones: La mayor cantidad de casos fueron electivos, con predominio de los troncos no protegidos. El factor de riesgo coronario más encontrado fue la HTA. Se encontró asociación significativa entre la diabetes mellitus y la localización ostial de la lesión tratada. / AbstractIntroduction and Objectives: Significant impairment of the left main coronary artery is the most lethal presentation of coronary artery disease. The treatment of choice

  14. Potencial evocado auditivo de tronco encefálico no prognóstico do coma superficial

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    Libia Camargo Ribeiro Leite

    2013-08-01

    Full Text Available O coma é a redução persistente do nível de consciência, arresponsivo a estímulos, devido à baixa atividade cerebral. Para verificar o nível de consciência, um recurso frequentemente utilizado é a Escala de Coma de Glasgow. Outro método que se destaca é o Potencial Evocado Auditivo de Tronco Encefálico, o qual avalia a atividade elétrica das vias auditivas ascendentes, desde o trajeto periférico até o mesencéfalo. O exame é simples, imune a medicamentos depressores e ambientes eletricamente carregados, sendo o mais adequado dos potenciais para a monitoração dos estados de coma. O presente estudo teve por objetivo verificar as características do Potencial Evocado Auditivo de Tronco Encefálico no estado de coma leve (Glasgow 7 - 8 e suas respectivas contribuições. Foi realizado um estudo prospectivo transversal em dois pacientes em coma (Glasgow 7, estado secundário a traumatismo cranioencefálico. Os resultados do exame evidenciaram presença de atividade elétrica em toda extensão da via estudada, em ambos os casos, com indicações de diferentes alterações, quanto à redução na latência entre os intervalos, morfologia e replicação das ondas. Tais diferenças foram contempladas com a evolução de cada caso: caso 1 evoluiu a alta hospitalar e caso 2 evoluiu a óbito. Os resultados confirmaram os achados da literatura, que descreve que a presença do Potencial Evocado Auditivo de Tronco Encefálico normal está associada à boa evolução do caso clínico, enquanto alterações no exame podem sinalizar para um mau prognóstico.

  15. Características biológicas das células-tronco mesenquimais

    OpenAIRE

    Bydlowski,Sergio P.; Debes,Adriana A.; Maselli,Luciana M. F.; Janz,Felipe L.

    2009-01-01

    Células-tronco são células indiferenciadas. Como tal, apresentam uma série de características que as tornam candidatas à utilização terapêutica. As principais características das células-tronco são a capacidade de autorrenovação e de se diferenciarem em diversos tipos celulares. Desta forma, acredita-se que células-tronco presentes nos diferentes tecidos tenham papel regenerativo quando estes sofrem uma lesão ou injúria. Entre os tecidos conhecidos por apresentarem células-tronco após a vida ...

  16. Células-tronco hematopoéticas em cães

    OpenAIRE

    Nakage,Ana Paula Massae; Santana,Aureo Evangelista

    2006-01-01

    As células-tronco hematopoéticas promovem a reconstituição hematopoética e de outros tecidos, estando presentes no embrião, sangue periférico, medula óssea e sangue do cordão umbilical. Os modelos experimentais de células-tronco em cães têm propiciado informações relevantes para transplantes de células-tronco em humanos. A capacidade de reconstituição hematopoética e da plasticidade das células-tronco de cães permite o emprego do modelo canino em várias propostas científicas e terapêuticas, q...

  17. Cerebral Aneurysm in the Evolution of Cardiac Myxoma: Clinical and Physiopathological Interpretations; El aneurisma cerebral en la evolucion del mixoma cardiaco: planteamientos clinicos y fisopatologicos

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    Rodriguez, R.; Garcia, M. L. [Hospital General Universitario Morales Meseguer. Murcia (Spain)

    2003-07-01

    We present the case of a patient with stroke, cerebral aneurysms (small distal and large proximal) who had been treated for cardiac myxoma 18 years earlier. We compared the imaging findings (localization, size, density and associated cerebral lesions) with those of other publications. The data obtained from other works and those that we could derive from our patient suggest that the cerebral aneurysms are responsible for neurological symptoms observed some time after removal of the tumor. On the other hand, such aneurysms tend to grow larger and more proximal with increasing time after surgery. (Author) 15 refs.

  18. A compreensão do significado cultural do aneurisma cerebral e do tratamento atribuídos pelo paciente e familiares: um estudo etnográfico La comprensión del significado cultural del aneurisma cerebral y del tratamiento atribuídos por el paciente y los familiares: un estudio etnográfico The cultural meaning of cerebral aneurysm and its treatment for the patient and relatives: an ethnographic study

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    Maria Helena Pinto

    2000-01-01

    Full Text Available Este trabalho consiste de um estudo etnográfico descritivo, com 13 pacientes acometidos pelo aneurisma cerebral e seus familiares, com o objetivo de compreender o significado da doença e do tratamento. Os dados foram coletados por entrevistas e observações durante a hospitalização e depois da alta, no ambulatório e na residência. O tema central obtido do estudo foi "Tinha que ser para mim. Deus sabe o que faz". Este tema revela uma interpretação religiosa para a doença e uma fundamentação mágica para o tratamento. Assim, o aneurisma cerebral é interpretado como uma doença material (corpo e uma doença espiritual (alma.Esta investigación consiste en un estudio etnográfico de los pacientes afectados por aneurisma cerebral y sus familiares, con el objetivo de objetivo de comprender el significado de la enfermedad y el tratamiento. Los datos fueron recolectados por entrevistas y observaciones durante la hospitalización y después del alta en la consulta externa y en la residencia. El tema central obtenido del estudio fue: "Tenia que ser para mi. Dios sabe lo que hace". Este tema manifiesta una interpretación religiosa para la enfermedad y una fundamentación mágica para el tratamiento. Así, el aneurisma cerebral es comprendido como una enfermedad material (del cuerpo y una enfermedad espiritual (del alma.This is a descriptive ethnographic study with 13 patients with cerebral aneurysm and their relatives aiming at understanding the meaning of the illness and the treatment. The data were collected by interviews and observations during the hospitalization and, after the discharge, in the outpatient clinic and at home. The central theme obtained from the study was "It had to be for me! God knows what He does". This theme reveals a religious interpretation for the illness and a magic basis for its cure.Thus, cerebral aneurysm is interpreted as a material illness (body and a spiritual illness (soul.

  19. El trastorno de conducta del sueño rem

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    Alex Iranzo De Riquer, Dr.

    2013-05-01

    Full Text Available El trastorno de conducta durante el sueño REM (TCSR se caracteriza por conductas motoras vigorosas, pesadillas y ausencia de atonía muscular durante el sueño REM. Se debe a la disfunción directa o indirecta de las estructuras del tronco cerebral que regulan el sueño REM, especialmente el núcleo subceruleus. El TCSR puede ser idiopático o asociado a enfermedades neurológicas como la enfermedad de Parkinson (EP, la demencia con cuerpos de Lewy (DCL, la atrofia multisistémica (AMS y la narcolepsia. Los pacientes con la forma idiopática, especialmente los que tienen alterados el SPECT del transportador de la dopamina, la sonografía de la sustancia negra, los test de olfato y de la visión de colores, tienen un elevado riesgo de desarrollar la E P, DCL y AMS. El TCSR no debe considerarse como un simple trastorno del sueño, sino como una manifestación de una enfermedad neurológica. El clonazepam (0.25-4 mg y la melatonina (3-12 mg a la hora de acostarse mejoran los síntomas del TCSR pero no evitan, en la forma idiopática, la conversión a una enfermedad neurodegenerativa.

  20. Transition of care for the elderly after cerebrovascular accidents - from hospital to the home Transición del cuidado del adulto mayor despues del accidente cerebral vascular del hospital para casa Transição do cuidado com o idoso após acidente vascular cerebral do hospital para casa

    Directory of Open Access Journals (Sweden)

    Rosalina Aparecida Partezani Rodrigues

    2013-02-01

    Full Text Available OBJECTIVE: to examine the transition of care in families caring for elderly persons who suffered the first episode of a cerebrovascular accident. METHODOLOGY: an instrumental ethnographic case study was used. The sample comprised 20 subjects: 10 caregivers and 10 elderly persons aged 65 or over, of both sexes, with diagnoses of first episode of cerebrovascular accident, capable of communicating, and requiring care from a main carer in their family. The data was collected through interviews, observation, existing documentation and field notes. Qualitative analysis techniques were used to codify and classify the data and to formulate significant categories, which generated typologies of care. RESULTS AND DISCUSSION: The central idea was the Transition of Care and showed the context in three typologies: The care process for the dependent elderly person, Strategies for the care process and Impact and acceptance of the limitations. CONCLUSION: The data indicates that caring for an elderly person after a cerebrovascular accident is a challenge for the family. The data permitted it possible to elaborate a proposal for a model for the organization of the work, with a view to holistic care delivery in the health services, forming a care network, which constitutes an advance for the area of nursing.OBJETIVO: examinar la transición del cuidado en familias que cuidan de adultos mayores que sufrieron el primer episodio de accidente cerebral vascular. METODOLOGÍA: Fue utilizado el estudio de caso etnográfico instrumental. La muestra fue constituida de 20 sujetos, siendo 10 cuidadores y 10 adultos con 65 años y más, de ambos sexos, con diagnóstico de primer episodio de accidente cerebral vascular, capaces de comunicarse, demandando cuidado de un cuidador principal en la familia. Los datos fueron colectados por medio de entrevistas, observaciones, documentos existentes y notas de campo. Fueron utilizadas las técnicas de análisis cualitativo para

  1. La parálisis cerebral como una condición dinámica del cerebro: un estudio secuencial del desarrollo de niños hasta los 6 años de edad / Cerebral Palsy as a Dynamic Condition of the Brain: A Sequential Study of the Development of Children up to 6 Years of Age

    Directory of Open Access Journals (Sweden)

    Enrique Moraleda Barreno

    2013-03-01

    Full Text Available La parálisis cerebral es un trastorno motor debido a inmadurez cerebral con numerosos déficits asociados, incluidos los adaptativos, sociales, motores, cognitivos y de la comunicación, y con gran impacto en el desarrollo. El objetivo del presente estudio fue estudiar el desarrollo durante un año de niños con parálisis cerebral de uno a seis años. El método empleado fue un diseño ex post facto evolutivo secuencial. Se utilizó la prueba de screening del Inventario de Desarrollo de Battelle en un pretest y en un postest transcurrido un año. La muestra estuvo compuesta por 41 niños de entre 1 y 6 años de edad con diagnóstico de parálisis cerebral infantil. Los niños mostraban puntuaciones en el postest significativamente superiores en todas las áreas estudiadas. Se observó una mejora generalizada en las capacidades de la mayoría de los sujetos. Se discuten las posibles influencias que contribuyen a estas mejoras en los cocientes de desarrollo en la obtención de estos resultados.

  2. Relación entre la potencia muscular de extremidades inferiores y tronco con la velocidad de salida de la bola en el swing de drive en golf

    OpenAIRE

    Lorena Torres Ronda; Joan Solé Fortó; Lisímaco Vallejo Cuéllar; Xavier Balius Matas

    2010-01-01

    A pesar del interés emergente en el acondicionamiento físico en el golf, se han llevado a cabo pocos estudios para valorar la relación entre la potencia mecánica y el rendimiento en golf. El objetivo de este estudio fue valorar si existía una correlación entre la velocidad de salida de la bola del swing de drive y la potencia muscular de extremidades inferiores y tronco, en un grupo de 8 golfistas (16,8 ± 1,4 años; 2,2 ± 1,8 Handicap; 63,1 ± 6,4 kg.; 172,7 ± 7,5 cm). El test incluyó medicione...

  3. La atorvastatina protege las neuronas gabérgicas y dopaminérgicas del sistema nigroestriatal en un modelo experimental de isquemia cerebral focal transitoria en ratas

    OpenAIRE

    Angélica María Sabogal; Cesar Augusto Arango; Gloria Patricia Cardona; Ángel Enrique Céspedes

    2014-01-01

    Introducción. La isquemia cerebral es la tercera causa de muerte y la primera de discapacidad permanente en el mundo. La atorvastatina es un fármaco neuroprotector prometedor para el tratamiento de la apoplejía; sin embargo, su acción sobre las poblaciones neuronales del sistema nigroestriatal después de la isquemia aún se desconoce. Objetivo. Evaluar el efecto de la atorvastatina sobre poblaciones gabérgicas y dopaminérgicas en regiones exofocales en un modelo de oclusión transitoria de ...

  4. Biomechanical analysis of countermovement jump in people with cerebral palsy Análisis biomecánico del salto vertical con contramovimiento en personas con parálisis cerebral

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    K. Gianikellis

    2010-09-01

    Full Text Available

    The main purpose of the study was to evaluate the patterns of the developed ground reaction forces in the two – legged countermovement jumping, performed by persons affected by tetraparesis with ataxia, tetraparesis with athetosis, tetraparesis with spasticity, diplegia with spasticity, right and left hemiplegia and, finally, right and left hemiparesis. After twenty subjects jumped on the surface of a force plate analysis of the ground reaction force – time trend took place. The obtained results confirm the accomplishment of the biomechanical principle of the initial force as in the case of persons not affected by neurological disorders. Finally the calculated ratio between the breaking impulse and the acceleration impulse is very near to optimum values.
    KEY WORDS: cerebral palsy, biomechanics, countermovement jump.

     

    El valor óptimo del impulso de aceleración en el salto vertical con contra -movimiento, es aproximadamente tres veces superior al impulso de “frenaje”. El objetivo de este estudio ha sido investigar el modo de actuación de la cadena biocinemática del tren inferior en el salto vertical con contra -movimiento para personas afectadas por parálisis cerebral, concretamente, tetraparesia con ataxia, tetraparesia con atetosis, tetraparesia con espasticidad, diplegia con espasticidad, hemiplegia izquierda y derecha, y finalmente, hemiparesia izquierda y derecha. Para ello, se han analizado las fuerzas de reacción de veintitrés sujetos que han realizado saltos con contramovimiento sobre una plataforma de fuerzas. El hallazgo de un valor medio de la ratio entre el impulso de “frenaje” y el de aceleración muy próximo al valor teórico para los veintitrés sujetos con diferentes síntomas de parálisis cerebral, confirma el principio de la fuerza inicial mientras que el alto coeficiente de variación de los parámetros utilizados en este estudio confirma la esperada

  5. Aplicación de la clasificación internacional del funcionamiento, de la discapacidad y de la salud para elaborar un perfil de necesidades de apoyo a una persona con parálisis cerebral

    OpenAIRE

    Chiorino Arroyo, Odemaris

    2004-01-01

    El presente artículo resume un trabajo llevado a cabo en un centro de adultos para personas con parálisis cerebral en Salamanca, pertenecientes a la Asociación de Padres de Personas con Parálisis Cerebral y Encefalopatías Afines (ASPACE). El objetivo fue aplicar la Clasificación Internacional del Funcionamiento, de la Discapacidad y de la Salud (CIF) a una persona con parálisis cerebral y discapacidad intelectual, con el fin de elaborar un perfil de necesidades de apoyo.

  6. Potenciais evocados auditivos de tronco encefálico em frentistas Auditory brainstem response in gas station attendants

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    Lenita da Silva Quevedo

    2012-12-01

    Full Text Available A ototoxidade dos solventes orgânicos pode atingir o sistema auditivo a nível coclear e retrococlear. OBJETIVO: Avaliar a integridade neurofisiológica do sistema auditivo até tronco cerebral por meio do PEATE. MÉTODO: Estudo prospectivo. Estudados frentistas de três postos de gasolina da cidade de Santa Maria/RS. A amostra ficou composta por 21 sujeitos, que foram avaliados por meio de potenciais evocados auditivos de tronco encefálico. RESULTADOS: Alteração nas latências absolutas das ondas I e III e em todas as latências interpicos, na orelha direita. Na orelha esquerda houve alteração na latência absoluta de todas as ondas, e em todos os intervalos interpicos. Alteração na diferença interaural da onda V foi verificada em 19% dos sujeitos. No grupo exposto há mais de cinco anos, foram estatisticamente significantes o número de sujeitos com alteração: no intervalo interpico I-V da orelha direita; na latência absoluta da onda I e no intervalo interpico III-V da orelha esquerda. CONCLUSÃO: A exposição a combustíveis pode causar alterações no sistema auditivo central.Ototoxicity of organic solvents can affect the hearing system up to the cochlea level and the central structures of hearing. OBJECTIVE: To evaluate the neurophysiological integrity of the hearing system in subjects exposed to fuels using ABR. METHOD: Prospective study. We evaluated attendants from three gas stations in Santa Maria/RS. The sample had 21 subjects, who were evaluated by auditory brainstem response. RESULTS: We found an alteration in the absolute latencies of Waves I and III and in all the interpeak latencies, in the right ear. In the left ear there was a change in the absolute latencies of all Waves, and in all the interpeak intervals. A change in the interaural difference of Wave V was found in 19% of the individuals. In the group exposed for more than five years, there were subjects with a statistically significant changes: in the I

  7. LA GIMNASIA CEREBRAL Y LA CREATIVIDAD DE LOS NIÑOS Y LAS NIÑAS DE 4 A 5 AÑOS DE EDAD DE LA UNIDAD EDUCATIVA LUIS A MARTINEZ DEL CANTÓN AMBATO PROVINCIA DEL TUNGURAHUA

    OpenAIRE

    Salazar Garcés, María Cristina

    2016-01-01

    El mundo actual requiere seres humanos con formación integral que fusione conocimientos, habilidades, destrezas, valores, la presente investigación sobre la gimnasia cerebral y la creatividad de los niños y las niñas de 4 a 5 años de edad de la Unidad Educativa Luis A. Martínez del Cantón Ambato, Provincia de Tungurahua, tiene como finalidad investigar el nivel de desarrollo de la creatividad de los niños mencionados, aplicando para ello encuestas dirigidas a los docentes, entrevistas a las a...

  8. Aneurisma del tronco principal de la arteria coronaria izquierda: Descripción de un caso clínico y revisión de tema Aneurysm of the main trunk of the left coronary artery: Description of a clinical case and literature review

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    Julio C Rodríguez

    2010-06-01

    Full Text Available El aneurisma arterial coronario constituye una entidad rara en la población; su incidencia varía entre 1,5% y 5%, siendo más frecuente en hombres. Existe escasa bibliografía acerca de esta patología a pesar de que su estudio se remonta a finales del siglo XVIII. La arteria que se afecta con mayor frecuencia es la coronaria derecha, aproximadamente en 40% de los casos. La dificultad al momento del diagnóstico clínico radica en que inicialmente el enfoque está dirigido a confirmar y tratar de manera oportuna el síndrome coronario agudo que con insistencia constituye la manifestación inicial con que cursan este tipo de pacientes; por ello el diagnóstico necesariamente requiere ayudas imaginológicas e intervencionistas, o ambas. Hay muchas causas que puedan producir aneurismas en la circulación coronaria, la más común de ellas es la aterosclerosisseguida por trastornos congénitos, enfermedades del tejido conectivo, vasculitis y consumo de cocaína entre otros. Recientemente se han publicado innovadores estudios respecto a la fisiopatología y los avances en terapéutica farmacológica e intervencionista, aunque el tratamiento debe enfocarse en los factores de riesgo, las patologías y las manifestaciones clínicas que presente el paciente.Coronary artery aneurysm is a rare entity in the population. Its incidence rates vary between 1.5% - 5%, and is more frequent in males. There is limited literature on this disease, although its study goes back to the late eighteenth century. The most frequently affected artery is the right coronary artery, in approximately 40% of cases. The initial diagnostic difficulty lies in the fact that the initial approach is focused in confirming and treating properly the coronary acute syndrome, which is the most frequent initial presentation in these patients. Therefore, its diagnosis requires necessarily imaging or interventionist aid, or both. Many causes account for coronary aneurysms, being the most

  9. La atorvastatina protege las neuronas gabérgicas y dopaminérgicas del sistema nigroestriatal en un modelo experimental de isquemia cerebral focal transitoria en ratas

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    Angélica María Sabogal

    2014-06-01

    Full Text Available Introducción. La isquemia cerebral es la tercera causa de muerte y la primera de discapacidad permanente en el mundo. La atorvastatina es un fármaco neuroprotector prometedor para el tratamiento de la apoplejía; sin embargo, su acción sobre las poblaciones neuronales del sistema nigroestriatal después de la isquemia aún se desconoce. Objetivo. Evaluar el efecto de la atorvastatina sobre poblaciones gabérgicas y dopaminérgicas en regiones exofocales en un modelo de oclusión transitoria de la arteria cerebral media. Materiales y métodos. Se utilizaron 28 ratas Wistar macho de ocho semanas de edad. Los ejemplares con isquemia simulada y los ejemplares sometidos a isquemia fueron tratados con atorvastatina (10 mg/kg y carboximetilcelulosa (placebo administrados por medio de sonda a las 6, 24, 48 y 72 horas después de la reperfusión. Se analizó la inmunorreacción de la descarboxilasa del ácido glutámico y de la tirosina hidroxilasa en el globo pálido, el putamen caudado y la sustancia negra. Resultados. Los datos confirmaron el daño neurológico y la pérdida celular en el putamen caudado. Se incrementó la inmunorreacción de la tirosina hidroxilasa en el globo pálido medial y la sustancia negra pars reticulata, disminuyendo la inmunorreacción de la descarboxilasa del ácido glutámico en el globo pálido lateral de los animales isquémicos tratados con placebo; sin embargo, el tratamiento con atorvastatina pudo revertirla, lo que logró una disminución significativa de la tirosina hidroxilasa en el globo pálido medial y la sustancia negra pars reticulata y aumentando los niveles de descarboxilasa del ácido glutámico en el globo pálido lateral. Conclusión. Nuestros datos sugieren que la atorvastatina en el tratamiento posterior a la isquemia ejerce neuroprotección en las zonas exofocales, modulando las poblaciones neuronales gabérgicas y dopaminérgicas del sistema nigroestriatal, lo que podría prevenir trastornos neurológicos.

  10. Anatomía Cerebral del mono araña Ateles geoffroyi estudiada utilizando imágenes de resonancia magnética. Primer reporte: estudio comparativo con el cerebro humano Homo Sapiens

    OpenAIRE

    Chico-Ponce de León, Fernando; Platas-Neri, Diana; Muñoz-Delgado, Jairo; Santillán-Doherty, Ana-María; Arenas-Rosas, Rita; Trejo, David; Conde, Rubén; Ojeda-Flores, Rafael; Campos-Romo, Aurelio; Castro-Sierra, Eduardo; Cervantes, Juan José; Braun, Marc

    2010-01-01

    El objetivo del presente estudio cualitativo fue analizar los aspectos morfológicos de la anatomía cerebral interna utilizando imágenes de resonancia magnética (IRM) en dos especies de primates, El mono Araña (A. geoffroyi) y el humano (H. sapiens), tomando como base un estudio comparativo de las estructuras cerebrales de las dos especies, concentrándose primordialmente en el sistema límbico del cerebro del mono araña. Aunque es una especie común en el hemisferio occidental, es interesante pa...

  11. Células-tronco do líquido amniótico

    OpenAIRE

    Bydlowski,Sergio P.; Debes,Adriana A.; Duarte,Sergio A.; Janz,Felipe L.; Cavaglieri,Rita de Cássia; Maselli,Luciana M. F.

    2009-01-01

    Desde o primeiro isolamento e cultivo de células-tronco embrionárias humanas, há mais de 10 anos, seu uso na pesquisa e terapia foi inibida por considerações éticas complexas e pelo risco de transformação maligna destas células indiferenciadas após transplante no paciente. As células-tronco adultas são eticamente aceitas e o risco de transformação maligna é muito baixo. Entretanto, seu potencial de diferenciação e sua capacidade proliferativa são limitados. Cerca de 6 anos atrás, a descoberta...

  12. Células tronco mesenquimales: definiciones, cultivo y aplicaciones potenciales

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    Willy Ceron

    Full Text Available En los últimos años, las células troncales mesenquimales (Mesenchymal Stem Cells, MSC han adquirido mucha importancia debido a su gran plasticidad y su capacidad de liberar factores paracrinos con capacidad de interactuar con diversos tipos celulares, tejidos y órganos. El uso de MSC en medicina regenerativa es importante debido a que, al no expresar las moléculas del complejo mayor de histocompatibilidad (MHC clase II ni moléculas co-estimuladoras y tener baja expresión del MHC clase I, haría que no sean rechazadas por individuos de la misma especie, es posible utilizarlas no sólo de manera autóloga, sino también, eventualmente, alogénica. Sin embargo, es importante demostrar científicamente muchas de sus propiedades, entre ellas las inmunomoduladoras. Al tener varias fuentes de obtención, se debe estandarizar la que sea la mejor para garantizar la pureza y calidad de las MSC. Finalmente, es importante que cuando se trabaje con estas células se demuestre completamente las características del cultivo celular, la inmunotipificación y su capacidad de diferenciación. Se están ensayando muchas aplicaciones clínicas de las MSC. Dentro de ellas, su capacidad para mejorar la recuperación y potencial curación de úlceras crónicas como las diabéticas, ha atraído la atención por su potencial impacto terapéutico.

  13. Parálisis del músculo oblicuo superior atípica

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    Pedro Daniel Castro Pérez

    Full Text Available Las paresias y parálisis oculomotoras implican todos aquellos procesos susceptibles de producir un déficit parcial o total de los movimientos del globo ocular. La lesión puede estar en cualquier parte del sistema oculomotor que incluye la corteza cerebral, el tronco cerebral, nervios, placa neuromuscular y del propio músculo. Las paresias y/o parálisis del músculo oblicuo superior o IV par craneal constituye una de las más frecuentes en la práctica médica estrabológica, puede ser de etiología congénita o adquirida, se caracteriza por hipertropía que aumenta con la inclinación de la cabeza hacia el hombro del lado del ojo afectado (signo de Bielschowsky, anisotropía en V, exciclotropía. Los pacientes con paresias y/o parálisis adquirida muestran diplopía vertical y torsional que aumenta con la mirada hacia abajo, tortícolis con inclinación de la cabeza hacia el lado opuesto del ojo afectado y descenso del mentón. El paciente acude a consulta por presentar diplopía vertical y torsional de 13 años de evolución. Al examen de la motilidad ocular había ortotropía en la Posición Primaria de la Mirada con hiperforia al cover test ojo izquierdo, 10 Dp base inferior por barra de prismas, exciclotropía 5*, tortícolis hacia la derecha y Bielschowsky positivo hacia el lado izquierdo. La impresión diagnóstica fue paresia adquirida del músculo OS izquierdo de etiología no precisada. El tratamiento realizado fue la retroinserción del recto superior del ojo izquierdo 4 mm más el desplazamiento temporal de un 1/4 de la inserción con el objetivo de eliminar la diplopía vertical y torsional y la posición anómala de la cabeza.

  14. Atividade eletromiográfica dos extensores de tronco durante manuseio pelo Método Neuroevolutivo Bobath

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    Aline de Souza Pagnussat

    Full Text Available INTRODUÇÃO: Paralisia cerebral é um distúrbio caracterizado por alterações no desenvolvimento da atividade, do movimento e da postura. O Conceito Neuroevolutivo Bobath é um método utilizado na reabilitação neuropediátrica, fundamentando-se na facilitação da aquisição de habilidades sensório-motoras de acordo com a sequência de desenvolvimento neuropsicomotor normal. OBJETIVO: Verificar atividade eletromiográfica de músculos envolvidos no controle cervical nos planos frontal, sagital e transverso, mediante manuseio em pontos-chave de controle, objetivando transferência de peso e estabilização corporal. MATERIAIS E MÉTODOS: Trata-se de uma avaliação quantitativa em um estudo de caso, no qual uma paciente de sete anos de idade, com diagnóstico clínico de paralisia cerebral e síndrome de West, foi submetida à análise eletromiográfica da musculatura envolvida no controle cervical, mediante manuseio em pontos-chave de controle. O registo ocorreu durante o manuseio utilizando postura de decúbito ventral sobre cunha e postura de decúbito lateral sobre o solo. RESULTADOS: O sinal eletromiográfico dos extensores e flexores na região cervical intensificou-se mediante manuseio para transferência de peso em ponto-chave de quadril em ambas as posturas. Embora o sinal de base tenha sido ampliado durante a transferência de peso para o quadril, o registro eletromiográfico nos segmentos musculares avaliados foi superior no decúbito lateral. CONCLUSÕES: Verificou-se que a transferência de peso para o quadril induziu facilitação do controle cervical e que o decúbito lateral de forma repetida e sustentada, mediante correto manuseio, alinhamento e transferência de peso, facilitou de forma mais pronunciada a atividade muscular na região cervical e de tronco superior do que o manuseio em decúbito ventral sobre a cunha.

  15. Comparação dos valores do índice bispectral em pacientes com paralisia cerebral em estado de vigília Comparación de los valores del índice bispectral en pacientes con parálisis cerebral en estado de vigilia Comparison of the bispectral index in awake patients with cerebral palsy

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    Verônica Vieira da Costa

    2007-08-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: O EEG-BIS foi criado por meio de estudos em pacientes adultos saudáveis e as primeiras publicações em crianças surgiram a partir de 1998. A paralisia cerebral (PC é secundária à lesão estática do encéfalo em desenvolvimento. A necessidade de realização de exames e procedimentos cirúrgicos para correção de deformidades sob anestesia ou sedação é comum nesses pacientes. Torna-se cada vez mais necessária a monitorização do estado de hipnose do paciente anestesiado e pode-se incluir nesse grupo os pacientes com paralisia cerebral. O objetivo desse estudo foi avaliar a eficiência do EEG-BIS nos pacientes com paralisia cerebral (PC em comparação com os pacientes sem doenças neurológicas (sem PC, em estado de vigília. MÉTODO: Foram avaliados dois grupos de pacientes: um com diagnóstico de paralisia cerebral e outro sem doença do sistema nervoso central (SNC. Na véspera da intervenção cirúrgica, na enfermaria, junto aos pacientes despertos era colocado o monitor de EEG-BIS e solicitado que fechassem os olhos. Os valores que apareciam na tela do monitor, em um intervalo de 10 minutos, eram anotados e registrados em ficha padronizada, sendo calculado um valor médio por paciente. RESULTADOS: Foram avaliados 188 pacientes, de ambos os sexos, com idade média de 10, 07 ± 2,9 (PC e 10,21 ± 3,1 (sem PC anos. O grupo PC apresentou EEG-BIS basal de 95,83 ± 5,142 e o grupo sem PC de 96,56 ± 1,941 sem haver diferença estatística significativa entre eles. CONCLUSÕES: Os sinais de EEG são captados normalmente e os valores de EEG-BIS dos pacientes com PC são semelhantes ao dos pacientes sem PC no estado de vigília.JUSTIFICATIVA Y OBJETIVOS: El EEG-BIS fue creado a través de estudios en pacientes adultos saludables y las primeras publicaciones en niños surgieron a partir de 1998. La parálisis cerebral (PC es secundaria a la lesión estática del encéfalo en desarrollo. La necesidad de

  16. Valor pronóstico del mapeo cerebral en la recuperación funcional del paciente con enfermedad cerebrovascular isquémica Pronostic value of brain mapping in the functional recovery of patients with ischemic cerebrovascular disease

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    Freddy Torres Candebat

    2012-10-01

    Full Text Available Se efectuó un estudio descriptivo longitudinal y prospectivo de 22 pacientes con ictus isquémico, que fueron ingresados en el Hospital General Docente "Dr. Juan Bruno Zayas Alfonso" de Santiago de Cuba desde enero de 2010 hasta igual mes de 2011, con vistas a establecer un pronóstico de recuperación funcional a partir del mapeo cerebral. Se realizó la valoración neurofisiológica y funcional mediante el índice de Barthel. En la serie estudiada la edad media fue de 57,2 años y predominó el sexo masculino. El mapeo cerebral se caracterizó por la presencia de actividad lenta (theta, delta y disminución de beta y alfa en regiones corticales ipsilaterales y contralaterales al territorio afectado por el foco isquémico; asimismo, la magnitud de estas alteraciones se correlacionó estrechamente con la ganancia funcional. La disminución de energía en las bandas alfa, asociada al incremento de esta en las bandas theta y delta, de tipo global, constituyeron índices de mal pronóstico rehabilitador.A longitudinal and prospective descriptive study was made in 22 patients with ischemic ictus that were admitted to "Dr. Juan Bruno Zayas Alfonso" Teaching General Hospital in Santiago de Cuba from January, 2010 to the same month of 2011, aimed at establishing a prognosis of functional recovery from the cerebral mapping. A neurophysiological and functional evaluation was carried out by means of Barthel index. In the studied series the mean age was 57.2 years and the male sex prevailed. Cerebral mapping was characterized by the presence of slow activity (theta, delta and beta and alpha decreases in cortical ipsilateral and contralateral regions to the territory affected by the ischemic focus; likewise, the magnitude of these changes was closely correlated with the functional gain. The energy decrease in the alpha bands associated with its increment in the theta and delta bands, of global type, constituted rates of bad rehabilitation prognosis.

  17. La aprehensión de las marcas a través del sistema de recompensa cerebral

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    Fredy Sánchez Merino

    2014-11-01

    Full Text Available La verdadera marca es la unión entre signo y producto/servicio, en cuanto tal unión es aprehendida por los consumidores, siendo entonces dicha aprehensión el fin último de los productores/proveedores. No existe una fórmula exacta para lograr tal grado de identificación entre las marcas y el público, pero los avances de las neurociencias aplicados al marketing han revelado una nueva perspectiva acerca de cómo estimular al cliente al punto límite, en aras de lograr la fidelización del mismo. Este intercambio derivaría en una continua evolución del cliente y la marca, dando lugar a toda una serie de nuevas cuestiones como las que conciernen a la segmentación permanente del mercado o a la invalidación de la autonomía del consumidor.

  18. La aprehensión de las marcas a través del sistema de recompensa cerebral

    Directory of Open Access Journals (Sweden)

    Fredy Sánchez Merino

    2014-12-01

    Full Text Available La verdadera marca es la unión entre signo y producto/servicio, en cuanto tal unión es aprehendida por los consumidores, siendo entonces dicha aprehensión el fin último de los productores/proveedores. No existe una fórmula exacta para lograr tal grado de identificación entre las marcas y el público, pero los avances de las neurociencias aplicados al marketing han revelado una nueva perspectiva acerca de cómo estimular al cliente al punto límite, en aras de lograr la fidelización del mismo. Este intercambio derivaría en una continua evolución del cliente y la marca, dando lugar a toda una serie de nuevas cuestiones como las que conciernen a la segmentación permanente del mercado o a la invalidación de la autonomía del consumidor.

  19. Efectos del consumo de ácidos grasos omega-3 sobre la salud cardiovascular, cerebral y diversas enfermedades del sistema nervioso central

    Directory of Open Access Journals (Sweden)

    Elba Cubero Castillo

    2016-10-01

    Full Text Available Se realizó una revisión de los trabajos publicados sobre los efectos del consumo de ácidos grasos omega-3, (ácido alfa-linolénico (AAL, ácido docosahexaenoico (ADH y ácido eicosapentaenoico (AEP sobre la salud de las personas en diferentes periodos de la vida. Se discuten los beneficios obtenidos en el ámbito de la salud sobre los sistemas circulatorio y nervioso. Se mencionan diferentes fuentes alimenticias de origen animal y vegetal en las que se encuentran disponibles los ácidos grasos omega-3, especialmente ADH y AEP. Se encontró que muchos de los tratamientos actuales de trastornos del sistema nervioso y de problemas cognitivos involucran el consumo de ácidos grasos omega-3, dando resultados positivos en diversos cuadros clínicos.

  20. Estudio de la conectividad del núcleo subtalámico y su aplicación a la cirugía de estimulación cerebral profunda.

    OpenAIRE

    Conde Sardón, Rebeca

    2015-01-01

    El papel modulatorio de la corteza motora y premotora sobre el n. subtámico representa la base de la terapia de Estimulación Cerebral Profunda (DBS). El objetivo del trabajo es la visualización de dicha conectividad mediante RM-dti y establecer su relación con los efectos clínicos de registro neuronal intraoperatorio y la estimulación crónica del n.subtalámico. Material y Métodos: Hemos estudiado 30 pacientes diagnosticados de enfermedad de Parkinson e intervenidos de estimulación Cere...

  1. Efectos del tratamiento fisioterapéutico con el Wii Balance board en las alteraciones posturales de dos niños con parálisis cerebral. Estudio de caso

    OpenAIRE

    Córdoba Castillo, Luisa Fernanda; Gómez Lozano, Viviana Carolina; Tello Fernández, Leidy Karina; Tovar Ruiz, Luz Ángela

    2015-01-01

    Introducción: Este estudio pretendió determinar los efectos del tratamiento fisioterapéutico con el accesorio Wii Balance Board y el juego Wii Fit Plus -ambos de la consola Wii, de la empresa Nintendo Company Limited- en las alteraciones posturales de niños con hemiparesia espástica. Materiales y métodos: Estudio de caso, realizado con la participación de dos niños con parálisis cerebral, tipo hemiparesia espástica del municipio de Popayán, Cauca, a quienes se les realizó una evaluación de la...

  2. Evaluación Neurofisiológica del Entrenamiento de la Imaginación Motora con Realidad Virtual en Pacientes Pediátricos con Parálisis Cerebral

    Directory of Open Access Journals (Sweden)

    M.D. Del Castillo

    2018-03-01

    Full Text Available Existen diversas evidencias que indican que los déficits motores en los pacientes de parálisis cerebral se asocian con problemas en la planificación motora que, a su vez, apuntan a una mermada capacidad para imaginar movimientos. La imaginación motora se ha revelado como una herramienta efectiva en el aprendizaje y la adquisición de habilidades motoras ya que comparte estructuras neuronales similares con la ejecución motora. En este trabajo se presenta un paradigma basado en un juego de realidad virtual para guiar la actividad mental del paciente que sirve a dos fines: estudiar su capacidad de imaginar movimientos e implicar y motivar al paciente en el entrenamiento de dicha capacidad. El estudio ha involucrado cuatro niños con parálisis cerebral espástica (edad media = 13.25 años, DS = 1.5 con lesión cerebral bilateral. Los resultados obtenidos del análisis de su actividad electroencefalográfica muestran que estos pacientes son capaces de emplear la imaginación motora en una tarea de marcha, indicada por la presencia del fenómeno ERD (Event Related Desynchronization en zonas corticales motoras, independientemente de su nivel funcional y de los miembros afectados.

  3. Isolamento e caracterização de células-tronco mesenquimais derivadas de anexos fetais equinos

    OpenAIRE

    De Vita, Bruna [UNESP

    2011-01-01

    O interesse nas pesquisas com células-tronco obtidas dos anexos fetais de diversas espécies aumentou muito nas últimas décadas em virtude de serem fontes de células-tronco adultas com potencial de diferenciação em diversas linhagens celulares, sem riscos de desenvolvimento de tumores malignos ao serem transplantadas e com a vantagem de possibilitar bancos de armazenamento, no entanto, os estudos para espécie equina ainda são escassos. O objetivo deste trabalho foi isolar, caracterizar e difer...

  4. Análise do comportamento do hemometabolismo cerebral durante endarterectomia carotídea com pinçamento transitório Análisis del comportamiento del hemometabolismo cerebral durante endarterectomia carotídea con pinzamiento transitorio Analysis of brain hemometabolism behavior during carotid endarterectomy with temporary clamping

    Directory of Open Access Journals (Sweden)

    Gastão Fernandes Duval Neto

    2004-04-01

    hipóxia oliguemica o desacoplamiento hemometabólico. El objetivo del presente estudio fue identificar las alteraciones del hemometabolismo cerebral, evaluados por medio de las alteraciones de la saturación de la oxihemoglobina en el bulbo de la vena yugular interna (SjO2, durante endarterectomia carotídea con pinzamiento, correlacionando esas alteraciones con factores con potencialidad de interferir con las mismas, principalmente la presión de CO2 expirada (P ET CO2 y la presión de perfusión cerebral (PPC. MÉTODO: Participaron del estudio 16 pacientes con enfermedad estenosante unilateral y sometidos al pinzamiento arterial transitorio durante endarterectomia carotídea. Los parámetros monitorizados (saturación de la oxihemoglobina en el bulbo de la vena yugular interna, stump pressure y la presión de CO2 expirado fueron analizados en los siguientes momentos: M1 - pre-pinzamiento; M2 - 3 minutos pos-pinzamiento; M3 - pre-despinzamiento; M4 - pos-despinzamiento. RESULTADOS: La comparación entre la SjO2 (%, Media ± DP en los períodos estudiados evidenció una diferencia entre la registrada en los momentos M1 (52,25 ± 7,87 y M2 (47,43 ± 9,19. Esa reducción inicial estabilizó durante el pinzamiento transitorio, con disminución en la comparación entre M2 y M3 (46,56 ± 9,25, sin significado estadístico (p = ns. En la fase pos despinzamiento, M4 (47,68 ± 9,12, la media de la SjO2 presentó una elevación, cuando comparada con los momentos de pinzamiento M2 e M3, más inferior al momento pre-pinzamiento M1 (M4 x M1 - p BACKGROUND AND OBJECTIVES: Carotid endarterectomy with temporary clamping changes cerebral blood flow and cerebral metabolic oxygen demand ratio with consequent oligemic hypoxia or hemometabolic uncoupling. This study aimed at identifying changes in brain hemometabolism, evaluated through changes in oxyhemoglobin saturation in internal jugular vein bulb (SvjO2 during carotid endarterectomy with clamping, and at correlating these changes

  5. Daño cerebral adquirido: percepción del familiar de las secuelas y su malestar psicológico

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    Elena López de Arróyabe Castillo

    2013-01-01

    Full Text Available Este estudio tuvo como objetivo evaluar la percepción que el familiar tiene de los problemas de la persona afectada por un daño cerebral adquirido y su asociación a sus propios síntomas de estrés, depresión y duelo. Participaron 223 familiares (cuidadores principales. Se desarrolló un inventario de 36 secuelas percibidas estructuradas en 6 factores: déficits cognitivos y sensoriales, cambios de personalidad, dependencia, actividad disminuida, trastornos emocionales y autoconciencia y percepción social disminuida. Los resultados mostraron que las secuelas percibidas tienen relativamente poco impacto en el malestar psicológico del familiar. Las secuelas con mayor asociación a los síntomas psicológicos fueron dependencia, asociada significativamente a sentimientos actuales de duelo, y la actividad disminuida, que se asocia a las respuestas involuntarias de estrés de aproximación y alejamiento. Estos datos contradicen la literatura que sostiene la relación causal entre secuelas percibidas y síntomas en los familiares, sugiriendo otro tipo de factores implicados.

  6. Muerte cerebral en una embarazada y sobrevida del feto Brain death in a pregnant woman and fetus survival

    Directory of Open Access Journals (Sweden)

    Raúl Mejía

    2008-12-01

    Full Text Available Se presenta el caso de una mujer de 29 años de edad que a consecuencia de una hemorragia cerebelosa presentó un cuadro de muerte cerebral mientras cursaba la 17 semana de su embarazo. Durante 56 días se mantuvo con sostén vital artificial, corrección de déficit hormonal, nutrición enteral y tratamiento de las infecciones. Durante la 25 semana de embarazo, por paro cardíaco se debió practicar una cesárea, naciendo un niño de 450 gramos. Se realizó una revisión de los casos similares publicados y se discuten algunos aspectos médicos, éticos y legales derivados de esta situación.A 29 year old woman suffered massive brain injury after a cerebellum hemorrhage at 17 weeks' gestation. Several hours later, and after brainstem test, she was declared brain dead. She was supported with intensive care during 56 days. After a cardiac arrest, on week 25, a 450 g infant was delivered through a cesarean section. The somatic support of mother and fetus according to the expected physiologic changes after brain death and its ethical implications are discussed.

  7. Pseudo-aneurisma post-traumático de tronco de arteria coronaria izquierda Post-traumatic false (pseudo aneurysm of the left main coronary artery

    Directory of Open Access Journals (Sweden)

    Melina M. Gallo

    2011-08-01

    Full Text Available El pseudo-aneurisma de arteria coronaria es extremadamente raro. Su historia natural es poco conocida y su tratamiento discutido. Se presenta el caso de un paciente con pseudo-aneurisma de tronco de la coronaria izquierda e infarto antero-apical del ventrículo izquierdo cinco años después de un paro cardíaco secundario a un traumatismo no penetrante de tórax. Se consideró entonces que la lesión no era pasible de corrección percutánea o quirúrgica por lo que se optó por tratamiento médico conservador. Una angiografía coronaria por tomografía computarizada multicorte realizada 10 años después del evento inicial mostró ausencia de progresión de la lesión.Coronary pseudo-aneurysm is an extremely rare entity. Its natural history is scarcely known and its treatment is controversial. We report a case of pseudo-aneurysm of the left main coronary artery associated with an antero-apical infarct of the left ventricle diagnosed five years after a cardiac arrest following a non-penetrating thoracic trauma. The patient was treated conservatively because percutaneous or surgical correction were not considered suitable for this lesion. A multidetector computed tomography coronary angiogram performed 10 years after the initial event showed no evidence of progression.

  8. Cerebral Palsy

    Science.gov (United States)

    Cerebral palsy is a group of disorders that affect a person's ability to move and to maintain balance ... do not get worse over time. People with cerebral palsy may have difficulty walking. They may also have ...

  9. Malaria cerebral Cerebral malaria

    Directory of Open Access Journals (Sweden)

    Carlos Hugo Zapata Zapata

    2003-03-01

    Full Text Available La malaria Cerebral (MC es la complicación más frecuente de la malaria por P. falciparum; aproximadamente el 90% de las personas que la han padecido se recuperan completamente sin secuelas neurológicas. Aún no se conoce con claridad su patogénesis pero se han postulado cuatro hipótesis o mecanismos posibles: 1 citoadherencia y secuestro de glóbulos rojos parasitados en la microvasculatura cerebral; 2 formación de rosetas y aglutinación de glóbulos rojos parasitados; 3 producción de citoquinas y activación de segundos mensajeros y, 4 apertura de la barrera hematoencefálica. Sin embargo, queda un interrogante sin resolver aún: ¿qué proceso se lleva a cabo para que el parásito, desde el espacio microvascular, pueda interferir transitoriamente con la función cerebral? Recientemente se ha utilizado el precursor de la proteína b-Amiloide como un marcador de daño neuronal en MC; este precursor será de gran ayuda en futuras investigaciones realizadas en nuestro medio que aporten información para comprender la patogénesis de la MC. Is the most common complication of P. falciparum malaria; nearly 90% of people who have suffered CM can recover without neurological problems. Currently there are four hypotheses that explain pathogenesis of CM: cytoadherence and sequestering of parasitized red blood cells to cerebral capillaries; rosette formation and parasitized red blood cells agglutination; production of cytokines and activation of second messengers and opening of the blood-brain barrier. However the main question remains to be answered; how the host-parasite interaction in the vascular space interferes transiently with cerebral function? Recently, the beta amyloid precursor peptide has been employed as marker of neural injury in CM. It is expected that the beta amyloid precursor peptide will help to understand the pathogenesis of CM in complicated patients of endemic areas of Colombia.

  10. Técnica de perfusión selectiva cerebral vía subclavia para la corrección de patologías del arco aórtico Selective cerebral perfusion technique by subclavian approach for correction of aortic arch pathology

    Directory of Open Access Journals (Sweden)

    Alejandro Escobar

    2007-08-01

    Full Text Available Objetivo: describir y evaluar la técnica de perfusión subclavia para protección cerebral selectiva con hipotermia moderada. Métodos: estudio descriptivo de 19 pacientes, a quienes se les practicó corrección de disección o aneurisma del arco aórtico mediante la utilización de esta técnica. Resultados: entre septiembre de 2002 y septiembre de 2005, se intervinieron 19 pacientes. El 68,4% eran hombres, con un promedio de edad de 54,05 ± 13,53 años. La disección de aorta tipo A correspondió al 57,8%; el 42,2% restante tenía aneurismas en alguna porción de la aorta con compromiso del cayado. El 73,7% tenía insuficiencia valvular aórtica. El 47,3% se encontró en clase funcional I, el 31,5% en clase II y el 21% en clase III. El 36,8% requirió revascularización coronaria. El tiempo promedio de perfusión cerebral selectiva fue de 28,95 ± 8,73 minutos; la perfusión sistémica fue de 163,31 ± 32,15 minutos, el pinzamiento aórtico fue de 135,36 ± 34,48 minutos y la temperatura promedio fue de 27º ± 0,94º centígrados. Hubo tres defunciones. No ocurrieron complicaciones neurológicas definitivas. Conclusión: esta técnica puede ser estandarizada para cirugías electivas o emergentes. Es una técnica simple, reproducible, que permite períodos de tiempo más prolongados para la reconstrucción del arco aórtico sin producir isquemia del tejido cerebral, tiempos de circulación extracorpórea más cortos, pocas complicaciones por sangrado, disminución del riesgo de embolización cerebral anterógrada y un excelente resultado neurológico final.Objective: describe and evaluate the subclavian perfusion technique for selective cerebral protection with moderate hypothermia. Methods: descriptive study of 19 patients to whom correction of the dissection or aneurysm of the aortic arch through the utilization of this technique was practiced. Results: between September 2002 and September 2005, 19 patients were operated. 68.4% were men

  11. Coste-beneficio del tratamiento farmacológico de la parálisis cerebral con espasticidad en México

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    Arroyave Loaiza Gilma

    2000-01-01

    Full Text Available Fundamento: La parálisis cerebral con espasticidad produce un alto grado de minusvalía, especialmente en los niños/as menores, su tratamiento se circunscribe a la disminución de las incapacidades pero no se cura totalmente. Existe una intervención farmacológica que permite una calidad de vida mejor, por lo cual se hace una evaluación de costo-beneficio de esa intervención, observando los logros individuales y los beneficios sociales. Métodos: El punto de partida es información nacional de México, obtenida de fuentes secundarias. A los datos base se les proyecta en escenarios tendenciales de crecimiento del problema de salud y se le aplican los cálculos que permiten dimensionar el problema, para derivar sus beneficios a partir de los indicadores: peso de la enfermedad y años de vida saludables perdidos y ganados, con lo cual se estima el beneficio social y económico que significa la intervención farmacológica que se analiza. Resultados: Los datos muestran que la intervención farmacológica produce un beneficio inmediato porque se disminuye el peso de la enfermedad de 0,92 a 0,40. En el nivel individual el máximo beneficio se expresa en el incremento de la calidad de vida de los menores entre 6 y 12 años que padecen la minusvalía, al pasar de 0,08 a 0,60 años de vida ajustados por calidad. En el nivel nacional se recuperarían 595.817 años de vida saludables, que serían perdidos al realizar la intervención. El valor monetario que significa la intervención corresponde a $ 2.725.00 pesos mexicanos ($ 283.00 dólares de Estados Unidos de América por administración del medicamento durante un año a cada niño con la minusvalía. Conclusiones: La intervención significa un coste bajo, porque revertir los procesos neurológicos y fisiológicos de la parálisis cerebral es imposible en la actualidad, por lo tanto incrementar la calidad de vida de los menores enfermos es el máximo beneficio posible. El análisis coste

  12. Análise clínico-qualitativa do discurso de uma criança com paralisia cerebral Análisis clinico-cualitativo del discurso de un niño con parálisis cerebral Cinical-qualitative analysis of the discourse of a child with cerebral palsy

    Directory of Open Access Journals (Sweden)

    Giselle Massi

    2009-12-01

    Full Text Available Esse artigo propõe uma reflexão sobre a constituição processual de produções linguístico-discursivas de uma criança com paralisia cerebral, à luz de situações interativas. Apresenta o método clínico-qualitativo como forma de investigação e intervenção linguístico-discursiva, privilegiando a interação socioverbal e a relação intersubjetiva. Os dados foram coletados longitudinalmente ao longo de um ano e quatro meses e as produções linguísticas de uma criança com paralisia cerebral de quatro anos e dois meses de idade foram analisadas de uma perspectiva discursiva. Assim, distantes de avaliações e tratamentos mensuráveis, os quais se pautam em tarefas mecânicas de codificação e decodificação de palavras isoladas, nossa pesquisa pautou-se na análise processual da construção conjunta da significação. Tal análise nos permite afirmar que, mediante o processo interlocutivo, essa criança ampliou seu papel no diálogo. Observamos como ela, de um momento inicial em que apresentava apenas fragmentos de enunciados, passou a estruturar narrativas mais completas.Ese artículo propone una reflección sobre la constitución procesual de producciones linguístico-discursivas de un niño con parálisis cerebral, a la luz de situaciones interactivas. Presenta el método clínico-cualitativo y la investigación como una forma de expresión y de lenguaje, discursivas, con el énfasis en la interacción socio-verbal y en la relación intersubjetiva. Los datos fueron recogidos longitudinalmente más de un año y cuatro meses y la producción linguística de un niño con parálisis cerebral con cuatro años y dos meses de edad fueron analizados bajo una perspectiva discursiva. Por lo tanto, lejos de las evaluaciones y tratamientos que son guiados por medios mecánicos, tareas de codificación y decodificación de palabras aisladas, nuestra investigación se orienta en el análisis del procedimiento de la construcción conjunta

  13. Cerebral microangiopathies

    International Nuclear Information System (INIS)

    Linn, Jennifer

    2011-01-01

    Cerebral microangiopathies are a very heterogenous group of diseases characterized by pathological changes of the small cerebral vessels. They account for 20 - 30 % of all ischemic strokes. Degenerative microangiopathy and sporadic cerebral amyloid angiography represent the typical acquired cerebral microangiopathies, which are found in over 90 % of cases. Besides, a wide variety of rare, hereditary microangiopathy exists, as e.g. CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy), Fabrys disease and MELAS syndrome (Mitochondrial myopathy, Encephalopathy, Lactic Acidosis, and Stroke-like episodes). (orig.)

  14. Histología y morfometría de piel del pez Eremophilus mutisii (Trychomecteridae, Siluriformes)

    OpenAIRE

    Bonilla Lizarazo, Rocío Johanna; Quintero Virguez, Marllury; Gómez Ramírez, Edwin; Rodríguez Caicedo, Daniel; Hurtado Giraldo, Hernán

    2008-01-01

    Se estudió la piel del pez dulceacuícola endémico de Colombia Eremophylus mutissi. Se tomaron muestras de piel (0.5x0.5 cm²) de 11 especimenes en seis partes del cuerpo (mandíbulas, cabeza dorsal, tronco dorsal, tronco caudal, tronco medial y abdominal). Se fijaron en formaldehído al 4%, con deshidratación en etanol al 95 % e isopropanol al 99%, inclusión en parafina y cortes a 5 µm. La piel está constituida por dos capas cutáneas (epidermis y dermis) y una capa subcutánea (hipodermis): la ep...

  15. Valoración del envejecimiento a partir de la conectividad funcional cerebral estimada mediante medidas de sincronización electroencefalográficas

    Directory of Open Access Journals (Sweden)

    Julián Jesús González

    2015-04-01

    Full Text Available En este trabajo estudiamos el envejecimiento cerebral fisiológico a partir del análisis de la conectividad electroencefalográfica (EEG funcional entre distintas zonas corticales en dos grupos de sujetos sanos entre 50-65 años y entre 66-80 años. Para ello, se realizaron (en reposo y ojos cerrados registros EEG digitales monopolares (256 Hz de frecuencia de muestreo referenciados al promedio de 16 canales/electrodos (6-frontales, 4-temporales, 2-centrales, 2-parietales, 2-occipitales. Estimamos la conectividad entre canales mediante la función de coherencia en las bandas de frecuencia delta/theta/alfa/beta, y mediante un índice (L de sincronización no lineal generalizada. Analizamos la conectividad individual entre todos los pares posibles de canales y la conectividad global de cada canal con el resto. Los resultados muestran que determinadas interdependencias individuales medidas por el índice L y por la coherencia en banda-delta, decrecen con la edad, especialmente para las conexiones centro-temporales-occipitales. Además, se observa un decrecimiento lineal significativo con la edad de los índices de interdependencia señalados,especialmente para las parejas y promedios individuales de las zonas señaladas. También las interdependencias globales, especialmente las de tipo no lineal, de ciertas zonas centro-laterales y posteriores declinan con la edad. Concluimos que, medidas individuales y globales de conectividad funcional EEG entre determinadas áreas corticales pueden ayudar a valorar objetivamente el envejecimiento neurofisiológico.

  16. Environmental and deteriorating state analyses of the watershed Riacho do Tronco, Boa Vista, PB, Brazil

    Directory of Open Access Journals (Sweden)

    Ronildo Alcântara Pereira

    2010-04-01

    Full Text Available This study proposes, from the subdivision of the watershed of Riacho do Tronco in eight sub-watersheds, to diagnose their potential for land use and occupation, determine the areas of conflicts in land use and the level of environmental deterioration of the watershed as a whole, to support planning and the consequent reduction of the expansion of desertification. Based on GIS analysis and field work, the environmental parameters that allowed the establishment of the roughness coefficient of each sub-watershed were calculated, following the methodology proposed by Rocha (1997 for the classification of the natural potential use of each watershed. The results showed that four sub-watersheds are suitable for agriculture, three for livestock and reforestation and one for reforestation only. It was also possible to diagnose land use and occupation of each one and to determine land use conflicts. This represented by inappropriate use of soil considering the natural vocation of some sub-watershed, as well as the occurrence of bare soil and mining activities that occur in some sub-watersheds. Thus, from the analysis of conflict in land use, areas to be afforested, availability for or intense use of agricultural lands and the estimate of areas where correct management practices have to be implemented, it was observed that the watershed of Riacho do Tronco has 42.7% of its area in deteriorated stage. Therefore, the high level of environmental deterioration is evident, with consequent risk of desertification. In addition, considering that this area is located in the Brazilian semi-arid region with economic activities practiced without conservation concerns, it is necessary that the government and organized society foster sustainable principles in the economic activities in this watershed.

  17. Método didáctico “Socioneuropsicológico” y la estimulación de la integración hemisférica cerebral, en educandos del nivel primario.

    Directory of Open Access Journals (Sweden)

    Guido Ayay Arista

    2017-05-01

    Full Text Available RESUMEN: La investigación, tuvo por objetivo sistematizar el método didáctico “Socioneuropsicológico”, en un cuerpo teórico conceptual, centrado principalmente en procedimientos que estimulen la predominancia en la integración hemisférica cerebral, derecha-izquierda, sobre la base de las teorías derivadas de la neurociencia y las ciencias de la educación. Se ha empleado el diseño de investigación denominado “diseño de grupos aleatorizados pre y post test”. La muestra,  estuvo conformada por educandos de dos secciones del sexto grado de la Institución Educativa “San Juan de la Libertad” - Chachapoyas, una de 17 educandos para el grupo experimental y otra de 15 para el grupo control. Las hipótesis contrastadas mediante el parámetro estadístico T-Student, revelan que la experimentación del método didáctico “Socioneuropsicológico”, evidencia estimulación significativa de la predominancia en la integración hemisférica cerebral, derecha-izquierda como resultados cuali-cuantitativos. Por consiguiente, se concluye, que la sistematización del método, estimula la integración hemisférica cerebral, de doce funciones bipolares. En el hemisferio cerebral izquierdo se estimulan la función verbal, analítica, simbólica, matemática, de abstracción, lógico-racional, temporal, audiovisual, intelectual, específica, de convergencia y de interpretación. En el hemisferio cerebral derecho se estimulan las funciones no verbal, sintética, espacial, artística, de concreción, emocional, atemporal, cinestésica, sensual, sistémica,  de divergencia y creatividad. Palabras  clave: Método didáctico, estimulación, neurociencias, predominancia, integración hemisférica,  hemisferios cerebrales.

  18. ANATOMÍA MACROSCÓPICA E IMAGENOLÓGICA DE LAS RAMAS PRECOCES DE LA ARTERIA CEREBRAL MEDIA. Macroscopic and radiological anatomy of early branches of the middle cerebral artery

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    Fernando Martínez

    2016-03-01

    Full Text Available Las ramas precoces de la arteria cerebral media son ramas corticales originadas del tronco de la citada arteria. Se trata de arterias que pueden nutrir importantes áreas de los lóbulos temporal, frontal o la ínsula. Por lo tanto, la oclusión de una de estas ramas producirá un área de isquemia con potenciales consecuencias. Se estudiaron 20 hemisferios cerebrales  de cadáveres adultos conservados en formol, y 20 angiografías silvianas realizando una comparación y correlación. En las piezas anatómicas, la arteria cerebral media terminó por bifurcación en el 100% de los casos y dicha bifurcación se sitúo en la porción esfenoidal (M1 en la mayoría de las piezas. Se encontraron ramas precoces en número de1 a4 en el 80%, totalizando 28 arterias, de las cuales 23 tenían destino temporal y 5 frontales. En el material angiográfico la cerebral media terminó por bifurcación en el 95% de los casos y la misma se ubicó en M1 en la mayoría de los casos. Se encontraron ramas precoces en el 70% de los estudios analizados, totalizando 19 ramos. De los mismos, 16 fueron temporales, 1 frontal y en 2 casos no se pudo determinar su destino. Consideramos que los datos anatómicos y angiográficos obtenidos por este y otros estudios son de utilidad en la planificación del clipado de  los aneurismas de la cerebral media. The early branches of the middle cerebral artery are cortical branches that arise from the trunk of this artery. These branches can supply significant areas in the temporal, frontal or insular lobes. Therefore, their occlusion may lead to ischemia and potential sequelae. We studied 20 cerebral hemispheres of formalin-fixed adult cadavers and 20 silvian angiographies in order to compare and correlate them. In the anatomical specimens, the middle cerebral artery ended bifurcating in 100% of the cases and such bifurcation occurred at the sphenoidal segment (M1 in most cases. Early branches ranging from 1 to 4 were found in 80

  19. Functional neurological evaluation of the brainstem. Part I: the blink reflex Evaluación neurofuncional del tallo cerebral. Parte I: Reflejo del parpadeo

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    Jaime Bedoya

    2009-11-01

    -layout-grid-align: none;">El reflejo de parpadeo es la respuesta neural que se obtiene en el músculo orbicular de los ojos, luego de estimular el nervio trigeminal, bien sea de manera simple o pareada, por medios eléctricos, mecánicos, acústicos, térmicos, químicos o magnéticos; cuando se estimula dicho nervio se obtienen tres respuestas llamadas R1, R2 y R3. R1 tiene latencia corta, viaja por fibras A beta y no se habitúa.

    R2 es de latencia mediana, viaja por fibras A beta o A delta, tiende a habituarse y la modulan estructuras suprasegmentales sensorimotoras. R3 es de latencia larga, se genera al estimular vías multisinápticas que involucran fibras tipo C, en una ruta compleja ponto-amígdalo-talámico-cerebelar.

    También se pueden registrar tres períodos silentes cuando el reflejo del parpadeo se obtiene mientras el individuo hace una contracción voluntaria muscular facial. El estudio funcional de este reflejo permite identificar con certeza si la lesión está en las vías aferentes o en las eferentes o si involucra una integración anormal sensorimotora debida a trastornos de los sistemas nerviosos central, autonómico o periférico. La ejecución correcta de estos estudios, así como su interpretación apropiada, con base en los mecanismos subyacentes de plasticidad neural, son guías para orientar mejor los protocolos de neurorrehabilitación.

     

  20. Efectividad del tratamiento conservador y/o toxina botulínica en la displasia de cadera en parálisis cerebral infantil espástica. Revisión sistemática

    OpenAIRE

    Busto Ruiz, Elena

    2014-01-01

    Objetivo: Estudiar la efectividad del tratamiento conservador y/o toxina botulínica tipo A en la prevención o tratamiento de la displasia o dislocación de la cadera en PCI espástica. Material y métodos: Se realizó una búsqueda bibliográfica en las bases de datos de Pubmed, Web of Science (WOS), PEDro y Cochrane Library. Las palabras clave utilizadas fueron hip dysplasia, hip dislocation, hip subluxation, cerebral palsy, treatment, management, child. Se incluyeron todo tipo d...

  1. ESCOAMENTO DA ÁGUA DA CHUVA PELO TRONCO DAS ÁRVORES EM UMA FLORESTA ESTACIONAL SEMIDECIDUAL

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    Alexandre Simões Lorenzon

    2015-06-01

    Full Text Available RESUMOEste trabalho foi desenvolvido na Estação de Pesquisas, Treinamento e Educação Ambiental Mata do Paraíso, situada no Município de Viçosa, na Zona da Mata de Minas Gerais, Brasil, e teve como objetivo avaliar o escoamento pelo tronco em um fragmento de Mata Atlântica, no período de agosto de 2009 a março de 2011. Para quantificar esse escoamento, foram demarcadas seis parcelas de 10 x 10 m, sendo em cada parcela adaptados coletores à base de poliuretano nos troncos das árvores com circunferência 15,0 cm. Um pluviômetro foi instalado em local aberto para quantificar a água diretamente da chuva. Além disso, realizou-se uma análise qualitativa dos indivíduos do escoamento pelo troco, avaliando a qualidade do fuste e da copa, posição no estrato da floresta e infestação de cipó. Em todo o período de análises, foram realizadas 75 medições. Nas parcelas de escoamento pelo tronco foram amostrados 126 indivíduos, distribuídos em 29 famílias e 59 espécies. A precipitação em aberto foi de 2.391,63 mm, e o escoamento pelo tronco somou 31,59 mm, ou 1,32% da precipitação em aberto. A espécie com maior escoamento pelo tronco foi a Euterpe edulis, com um volume médio de água escoado de 637,00 L. Das espécies com maior escoamento pelo tronco, 73,91% encontravam-se no estrato inferior da floresta, evidenciando que algumas espécies possuem algum tipo de adaptação morfológica para captação da água da chuva.

  2. La atorvastatina protege las neuronas gabérgicas y dopaminérgicas del sistema nigroestriatal en un modelo experimental de isquemia cerebral focal transitoria en ratas

    OpenAIRE

    Sabogal, Angélica María; Arango, César Augusto; Cardona, Gloria Patricia; Céspedes, Ángel Enrique

    2014-01-01

    Introduction: Cerebral ischemia is the third leading cause of death and the primary cause of permanent disability worldwide. Atorvastatin is a promising drug with neuroprotective effects that may be useful for the treatment of stroke. However, the effects of atorvastatin on specific neuronal populations within the nigrostriatal system following cerebral ischemia are unknown. Objective: To evaluate the effects of atorvastatin on dopaminergic and GABAergic neuronal populations in exofocal brain...

  3. Cerebral vasculitis

    International Nuclear Information System (INIS)

    Greenan, T.J.; Grossman, R.I.

    1990-01-01

    This paper reviews retrospectively MR, CT, and angiographic findings in patients with cerebral vasculitis in order to understand the strengths and weaknesses of the various imaging modalities, as well as the spectrum of imaging abnormalities in this disease entity. Studies were retrospectively reviewed in 12 patients with cerebral vasculitis proved by means of angiography and/or brain biopsy

  4. Potenciais evocados auditivos de tronco encefálico em fumantes

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    Denise Miranda Terra Martins

    2016-02-01

    Full Text Available RESUMO Objetivo: comparar os resultados dos exames de potenciais evocados auditivos de tronco encefálico em indivíduos não tabagistas e tabagistas. Métodos: foram estudados 40 indivíduos, sendo 20 não tabagistas e 20 tabagistas, com idades entre 20 e 59 anos. Todos os participantes incluídos na pesquisa deveriam apresentar respostas de limiares tonais dentro dos padrões da normalidade e timpanometria tipo A com presença de reflexos acústicos contralaterais e ipsilaterais. Em ambos os grupos foram realizados os potenciais evocados auditivos de tronco encefálico (PEATE, por meio de cliques. Os parâmetros que foram utilizados na comparação dos dois grupos foram as latências absolutas das ondas I, III e V; as interlatências das ondas I-III, I-V e III-V em ambas as orelhas; a diferença da latência interpico I-V entre as duas orelhas e a diferença interaural da latência absoluta da onda V entre as duas orelhas. Resultados: os resultados encontrados mostraram que o grupo de tabagistas apresentou latência I da Orelha Direita (p=0,036, latência V da Orelha Direita (p=0,007, latência V da Orelha Esquerda (p=0,014, interlatência III-V da Orelha Direita (p=0,015 e Orelha Esquerda (p=0,016 significantemente maior que o grupo de não tabagistas. Não houve diferença significante na latência da onda V entre as duas orelhas. Conclusão: os resultados da pesquisa levaram à conclusão de que o tabaco é um fator de risco para o sistema nervoso auditivo central, que pode interferir nas latências e interlatências das ondas do PEATE no grupo de tabagistas quando comparado com o grupo de não tabagistas.

  5. Desarrollo radical en plantas de duraznero sometidas a diferentes manejos del suelo

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    GONZALEZ, J.1;

    2012-10-01

    Full Text Available El objetivo de este trabajo fue evaluar la incidencia del sistema de manejo y la textura del suelo sobre el desarrollo del sistema radicular y el diámetro de tronco del duraznero cv Dixiland cultivado sobre un Argiudol vértico de la Serie Ramallo bajo condiciones de secano, en el norte de la provincia de Buenos Aires, Argentina.Se ensayó con tres sistemas de manejo del suelo: labores mecánicas, sin labranza con control químico de malezas y cobertura vegetal. Se caracterizó la distribución de raíces en sentido horizontal y vertical por medio del número de raíces obtenido con el método de “trinchera”. Se determinó la densidad aparente con el método del cilindro, la textura de los horizontes del suelo hasta los 75 cm de profundidad y el diámetro de tronco.Los resultados obtenidos mostraron que, tanto el laboreo mecánico como el no laboreo del suelo con control químico de malezas, están asociados a un mayor desarrollo del diámetro del tronco y del sistema radicular en los primeros 40 cm. de profundidad respecto del tratamiento con cobertura vegetal. El desarrollo del estratosuperficial de raíces se ve restringido, tanto por el laboreo mecánico como por la cobertura vegetal del sueloy la textura explica su desarrollo en profundidad.

  6. Análisis de las implicancias del vínculo afectivo en el desarrollo motor y cognitivo de niños con parálisis cerebral

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    Maria Noelia Turchetti Iturrieta

    2016-12-01

    Full Text Available El desarrollo del niño está íntimamente ligado a los procesos de maduración del Sistema Nervioso Central (SNC, fundamentalmente en lo que se refiere a las funciones psicomotoras. Dentro de las alteraciones del SNC se encuentra la Parálisis Cerebral (PC, entendida como trastorno del tono postural y del movimiento, secundario a una lesión del cerebro inmaduro. La necesidad de la experiencia sensorial y el ejercicio motor es una premisa básica para el desarrollo infantil típico, haciéndose aún más necesaria en el niño con PC.La estimulación de las funciones motoras y cognitivas, debe darse en el marco de un vínculo de afecto con el niño con PC, a fin de establecer un clima de confianza que permita al niño trabajar junto al psicólogo en pos de su desarrollo. El objetivo del presente trabajo es analizar las implicancias del vínculo afectivo en el desarrollo motor y cognitivo de niños con PC, de entre 4 y 6 años de edad. Metodológicamente los datos son tratados cualitativamente, se trata de un estudio de casos seleccionados de forma intencional: se toman dos pacientes en tratamiento psicológico desde temprana edad, de una institución privada dedicada al abordaje interdisciplinario de las patologías de la infancia. Los pacientes designados presentan diagnóstico de P.C, de distinta complejidad, se comparan los sentimientos de los niños y su psicoterapeuta, durante su interrelación. Se utilizan como instrumentos para el relevamiento de datos, observación de la sesión psicológica y entrevista semidirigida a psicoterapeuta infantil. Entre los resultados se destacan la relación de la vulnerabilidad física y psíquica del niño con PC, siendo la desvitalización anímica, de la que habla Jorge Cantis, mayor en el paciente con diagnóstico de PC grave o severa. En relación al psicoterapeuta, se observa la necesidad de estar atento a sus sentimientos, para no identificarse con los sentimientos del paciente con P.C y/o de su

  7. Evidencias de compromiso cerebral en el estadio crónico de la enfermedad de Chagas obtenidas por medio del potencial P300 y de electroencefalografía cuantificada

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    PROST JULIO OSCAR

    2000-01-01

    Full Text Available Es reconocido el compromiso del sistema nervioso periférico en la etapa crónica de la enfermedad de Chagas, incorporándose últimamente evidencias tomográficas y neuropsicológicas de compromiso cerebral. Con el objetivo de evaluar dicho compromiso por medio del potencial P 300 y la electroencefalografía cuantificada (EEGc se estudiaron 35 pacientes (26 a 55 años, comparados con un grupo control de similar número y edad (29 a 55 años. Se observó: latencia de la onda P 3 mayor en el grupo en estudio (331,24 ± 24,02 contra 318,86 ± 23,18 (p=0,01716. El EEGc mostró diferencias en la potencia relativa de la banda Beta 1, menor en los pacientes (p=1,62834E5 y en la frecuencia dominante, 1 Hz menor en los chagasicos (p=0,01077. El análisis multivariado discrimina tres subpoblaciones: una normal, una de enfermos con incremento alfa y otra de enfermos con decremento alfa e incremento delta y theta (p=0,00004. La proporción de resultados patológicos fue del 20 % en los EEGc y el 11,43 % en los potenciales cognitivos. No se correlacionó el compromiso neurológico y el cardíaco. Se concluye que existen francos indicadores electrofisiológicos de compromiso cerebral en el estadio crónico de la enfermedad de Chagas, hallazgo que refuerza a los obtenidos por otros métodos.

  8. Células-tronco do líquido amniótico Amniotic fluid stem cells

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    Sergio P. Bydlowski

    2009-05-01

    Full Text Available Desde o primeiro isolamento e cultivo de células-tronco embrionárias humanas, há mais de 10 anos, seu uso na pesquisa e terapia foi inibida por considerações éticas complexas e pelo risco de transformação maligna destas células indiferenciadas após transplante no paciente. As células-tronco adultas são eticamente aceitas e o risco de transformação maligna é muito baixo. Entretanto, seu potencial de diferenciação e sua capacidade proliferativa são limitados. Cerca de 6 anos atrás, a descoberta de célulastronco no líquido amniótico que expressavam Oct-4, um marcador específico de pluripotencialidade, com alta capacidade de proliferação e diferenciação, iniciou um novo campo promissor na área das células-tronco. Estas células têm potencial de se diferenciar em células dos três folhetos germinativos. Não formam tumores in vivo e não levantam os questionamentos éticos associados com as células-tronco embrionárias humanas. Futuras investigações revelarão se as células-tronco do líquido amniótico realmente irão representar um tipo intermediário com vantagens em relação tanto às células-tronco embrionárias quanto às adultas. Este artigo faz uma revisão acerca destes tópicos e das características biológicas das células-tronco do líquido amniótico.Since the first successful isolation and cultivation of human embryonic stem cells about 10 years ago, their use for research and therapy has been constrained by complex ethical considerations as well as by the risk of development of malignancies of undifferentiated embryonic stem cells after transplantation into the patient. Adult stem cells are ethically acceptable and the risk of tumor development is low. However, their differentiation potential and proliferative capacity are limited. About 6 years ago, the discovery of Oct-4 expressing amniotic fluid stem cells, a specific marker of pluripotency, with a high proliferative capacity, and multilineage

  9. Paracoccidioidomicose em hemisfério cerebral e tronco encefálico: relato de caso Paracoccidioidomycosis in cerebral hemisphere and brainstem: case report

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    Manoel Baldoino Leal Filho

    2006-09-01

    Full Text Available Relata-se sobre um homem de 36 anos com passagem quatro anos antes pela selva amazônica. Admitido após seis meses do aparecimento progressivo de tetraparesia, ataxia de marcha, disfagia, disartria, dispnéia e soluço. A ressonância magnética revelou lesão parietoccipital à direita e no bulbo, sendo esta última maior. Investigações para tuberculose e síndrome da imunodeficiência adquirida tiveram resultados negativos. Foi submetido a microcirurgia da lesão do bulbo. O estudo anatomopatológico revelou paracoccidioidomicose. Recebeu tratamento com anfotericina B até 2100 mg, e sulfametoxazol-trimetoprim por três meses, e fisioterapia. Voltou às atividades após seis meses do término do tratamento. Comenta-se sobre a participação do sistema imunológico e das citocinas (interleucinas.We report on a 36 years-old man that had been at the Amazon forest four years before. Six months before the admission he had developed a progressive quadriparesis, gait ataxia, dysphagia, dysarthria, difficulty in breathing and hiccup. The gadolinium-enhanced T1-weighted MRI showed a lesion into the right parietoccipital area and another into the medulla, that was the largest. There was any evidence of tuberculosis or AIDS. The patient was submitted to microsurgical approach to the medulla. Pathological examination revealed paracoccidioidomycosis. Treatment with anphotericin B till 2100mg was administered followed by sulfamethoxazole-trimetoprim for three months plus physical therapy. The patient went back to his activities six months after the end of the treatment. Comments are presented about the participation of the immunological system and of the cytokines (interleukines.

  10. Emergindo a complexidade do cuidado de enfermagem ao ser em morte encefálica Complejidad emergente del cuidado de enfermería al paciente con muerte cerebral Emerging the complexity of nursing care facing a brain death

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    Aline Lima Pestana

    2012-12-01

    Full Text Available O estudo objetivou desvelar a complexidade do cuidado de enfermagem ao ser em morte encefálica. Utilizaram-se como referenciais teórico e metodológico o pensamento complexo e a Grounded Theory, respectivamente. Os dados foram coletados em um hospital universitário do nordeste brasileiro, de dezembro de 2010 a junho de 2011, por meio de entrevistas não estruturadas. A amostra teórica constituiu-se de 12 enfermeiros, distribuídos em três grupos amostrais. O fenômeno "Desvelando relações e interações múltiplas do ser enfermeiro na complexidade do cuidado ao ser em morte encefálica" foi delimitado por cinco categorias. Neste artigo, foi abordada a categoria "Emergindo a complexidade do cuidado de enfermagem ao ser em morte encefálica". O estudo evidenciou que o cuidado ao ser em morte encefálica é caracterizado por desordem e incertezas, fazendo com que o enfermeiro vivencie sentimentos diversos e ambivalentes. A sua complexidade está em compreender a sua singularidade e dialogicidade.Este estudio objetivó desvelar la complejidad del cuidado en enfermería al paciente con muerte encefálica. Se utilizaron como marcos teórico y metodológico el pensamiento complejo y la Grounded Theory, respectivamente. Los datos fueron recolectados en un hospital universitario en el nordeste de Brasil, entre diciembre de 2010 y junio de 2011, a través de entrevistas no estructuradas. La muestra teórica fue compuesta por 12 enfermeras asignadas en tres grupos. El fenómeno "Revelando las múltiples relaciones e interacciones en ser un enfermero en la complejidad del cuidado del paciente con muerte cerebral" fue delimitada en cinco categorías. En este artículo, se dirigió a la categoría de "Emergiendo la complejidad del cuidado de enfermería al paciente en muerte cerebral". El estudio mostró que el cuidado al ser en muerte cerebral se acompaña de desorden e incertidumbres, haciendo con que la enfermera pueda experimentar diferentes y

  11. Evaluación de la seguridad del nimotuzumab en pacientes con cáncer de pulmón de células no pequeñas portadores de metástasis cerebral

    Directory of Open Access Journals (Sweden)

    Nadia Aguilera Calvo

    2015-06-01

    Full Text Available Fundamento: nimotuzumab es un novedoso anticuerpo monoclonal humanizado, con efecto antitumoral, que reconoce el receptor del factor de crecimiento epidérmico sobrexpresado en muchos tumores malignos de origen epitelial, como: esófago, pulmón, glioblastoma multiforme y próstata. Es usado en combinación con las terapias oncoespecificas, como quimioterapia o radiosensibilizador. Hasta la fecha se han tratado más de 2000 pacientes con este producto, además, es el primer anticuerpo monoclonal registrado en el país para pacientes pediátricos. Objetivo: describir los eventos adversos asociados con el nimotuzumab en pacientes con cáncer de pulmón de células no pequeñas portadores de metástasis cerebral incluidos en un ensayo clínico. Métodos: se analizaron las características de base de los pacientes, así como la frecuencia, intensidad y relación de causalidad de los eventos reportados. La población de estudio la conformaron todos los pacientes incluidos en el ensayo clínico. Resultados: la mayoría de los eventos fueron de intensidad leve a moderada y no requirieron la suspensión del tratamiento. Los eventos adversos más frecuentes fueron: astenia, anorexia, cefalea y vértigos; efectos reportados en estudios previos. Conclusiones: nimotuzumab es un fármaco seguro para el tratamiento de pacientes aquejados de cáncer de pulmón de células no pequeñas y metástasis cerebral.

  12. Cenário internacional da pesquisa em células-tronco embrionárias Escenario internacional de la pesquisa en células madre embrionarias International perspective on embryonic stem cell research

    Directory of Open Access Journals (Sweden)

    Debora Diniz

    2009-06-01

    Full Text Available OBJETIVO:Analisar comparativamente regulações governamentais entre países sobre pesquisa em células-tronco embrionárias. MÉTODOS:O estudo foi conduzido entre março e maio de 2008, por meio de busca eletrônica direta nas fontes oficiais sobre documentos legislativos de 25 países selecionados e confirmada, quando necessário, por consulta por e-mail a pesquisadores e autoridades desses países. RESULTADOS: Os resultados mostraram tendência a permitir a prática de pesquisas com células-tronco embrionárias, embora com rígidas restrições éticas. Dentre os países estudados, apenas Itália e Alemanha explicitamente condenam a extração de células-tronco e apenas Itália proíbe seu uso subseqüente. Decisões jurídicas brasileiras recentes são coerentes com o contexto regulatório internacional sobre pesquisa embrionária. CONCLUSÕES: A tendência observada representa a liberdade de pesquisa para a promoção do conhecimento como um bem público, reforçada pela expectativa de potencialidade terapêutica na pesquisa com células-tronco embrionárias para o tratamento e cura de doenças sem qualquer possibilidade de assistência médica.OBJETIVO:Analizar comparativamente regulaciones gubernamentales entre países sobre pesquisa en células madre embrionarias. MÉTODOS:El estudio fue conducido entre marzo y mayo de 2008, por medio de búsqueda electrónica directa en las fuentes oficiales sobre documentos legislativos de 25 países seleccionados y confirmada, cuando era necesario, por consulta por e-mail a investigadores y autoridades de esos países. RESULTADOS:Los resultados mostraron tendencia a permitir la práctica de pesquisas con células madre embrionarias, a pesar de que con rígidas restricciones éticas. Entre los países estudiados, apenas Italia y Alemania explícitamente condenan la extracción de células madre coherentes con el contexto regulatorio internacional sobre pesquisa embrionaria. CONCLUSIONES: La tendencia

  13. A telomerase em células-tronco hematopoéticas Telomerase in hematopoietic stem cells

    Directory of Open Access Journals (Sweden)

    Silvana Perini

    2008-02-01

    Full Text Available A proliferação das células-tronco hematopoéticas sofre a perda dos telômeros a cada divisão celular. Alguns autores discordam quanto à perda ou não do potencial proliferativo e capacidade de auto-renovação das células mais diferenciadas. Revisaremos aqui o papel da telomerase na biologia do sistema hematopoético, na diferenciação normal ou maligna, assim como no envelhecimento das células-tronco hematopoéticas. A constante renovação celular requerida pela hematopoese confere às células-tronco embrionárias, assim como à maioria das células tumorais, um aumento da capacidade proliferativa marcada pela detecção da enzima telomerase e possível manutenção dos telômeros. Estudos clínicos se farão necessários para esclarecer melhor a atividade da telomerase em células-tronco hematopoéticas, seu possível uso como marcador de diagnóstico e seu uso a fim de propósitos prognósticos.Hematopoietic stem cell proliferation leads to telomere length decreases at each cellular division. Some authors disagree about the telomere influence on the reduction of the proliferative potential and capacity of self renewal. Here we review telomerase function in the biology of the hematopoietic system, in normal or differentiation and its influence on the ageing of hematopoietic stem cells. The constant cellular renewal required to maintain the hematopoietic system, provides embryonic stem cells, as well as malignant cells, an increased proliferative capacity. This is marked by the detection of telomerase enzyme activity and possible telomere maintenance. Clinical trials will be required to clarify telomerase activity in hematopoietic stem cells, its possible use as a diagnostic marker and its use for prognostic purposes.

  14. [Cerebral protection].

    Science.gov (United States)

    Cattaneo, A D

    1993-09-01

    Cerebral protection means prevention of cerebral neuronal damage. Severe brain damage extinguishes the very "human" functions such as speech, consciousness, intellectual capacity, and emotional integrity. Many pathologic conditions may inflict injuries to the brain, therefore the protection and salvage of cerebral neuronal function must be the top priorities in the care of critically ill patients. Brain tissue has unusually high energy requirements, its stores of energy metabolites are small and, as a result, the brain is totally dependent on a continuous supply of substrates and oxygen, via the circulation. In complete global ischemia (cardiac arrest) reperfusion is characterized by an immediate reactive hyperemia followed within 20-30 min by a delayed hypoperfusion state. It has been postulated that the latter contributes to the ultimate neurologic outcome. In focal ischemia (stroke) the primary focus of necrosis is encircled by an area (ischemic penumbra) that is underperfused and contains neurotoxic substances such as free radicals, prostaglandins, calcium, and excitatory neurotransmitters. The variety of therapeutic effort that have addressed the question of protecting the brain reflects their limited success. 1) Barbiturates. After an initial enthusiastic endorsement by many clinicians and years of vigorous controversy, it can now be unequivocally stated that there is no place for barbiturate therapy following resuscitation from cardiac arrest. One presumed explanation for this negative statement is that cerebral metabolic suppression by barbiturates (and other anesthetics) is impossible in the absence of an active EEG. Conversely, in the event of incomplete ischemia EEG activity in usually present (albeit altered) and metabolic suppression and hence possibly protection can be induced with barbiturates. Indeed, most of the animal studies led to a number of recommendations for barbiturate therapy in man for incomplete ischemia. 2) Isoflurane. From a cerebral

  15. Motivo de retirada do cateter de Hickman em pacientes submetidos ao transplante de células-tronco hematopoéticas Rationale for Hickman catheter removal in patients undergoing hematopoietic stem cell transplantation

    Directory of Open Access Journals (Sweden)

    Lais Carvalho Castanho

    2011-01-01

    Full Text Available OBJETIVO: Identificar os motivos da retirada do primeiro cateter de Hickman implantado em pacientes submetidos ao transplante de células-tronco hematopoéticas alogênico, os micro-organismos envolvidos na ocorrência de infecção e o tempo de permanência do cateter in situ. MÉTODOS: Estudo transversal retrospectivo. A amostra foi constituída por 57 prontuários de pacientes transplantados. Para a obtenção dos dados, elaborou-se um instrumento contendo variáveis relativas à identificação do paciente, tempo de permanência do cateter, motivo de retirada e micro-organismo isolado. RESULTADOS: Dentre os motivos de retirada do cateter, destacou-se como o mais frequente a infecção (49%. O Stenotrophomonas maltophilia (25% foi o micro-organismo identificado com maior frequência. CONCLUSÕES: Diante da elevada incidência de complicações infecciosas que levam à retirada do cateter de Hickman, faz-se necessária uma padronização de cuidados relacionados a esse cateter, tanto para a equipe de saúde como ao paciente e seu cuidador.OBJETIVO: Identificar los motivos del retiro del primer catéter de Hickman implantado en pacientes sometidos al transplante de células-tronco hematopoéticas alogénico, los microorganismos involucrados en la ocurrencia de infección y el tiempo de permanencia del catéter in situ. MÉTODOS: Estudio transversal retrospectivo. La muestra estuvo constituída por 57 historias clínicas de pacientes transplantados. Para la obtención de los datos, se elaboró un instrumento conteniendo variables relativas a la identificación del paciente, tiempo de permanencia del catéter, motivo del retiro y microorganismo aislado. RESULTADOS: Entre los motivos del retiro del catéter, se destacó como el más frecuente la infección (49%. El Stenotrophomonas maltophilia (25% fue el microorganismo identificado con mayor frecuencia. CONCLUSIONES: Frente a la elevada incidencia de complicaciones infecciosas que llevan al

  16. Comprometimento social de pacientes submetidos ao transplante de células-tronco hematopoéticas

    Directory of Open Access Journals (Sweden)

    Vanessa da Rocha

    2016-06-01

    Full Text Available RESUMO Objetivo: avaliar o comprometimento dos domínios sociais e emocionais de pacientes internados submetidos ao Transplante de Células-Tronco Hematopoéticas. Método: estudo observacional, longitudinal, com 25 participantes, avaliados no período pré-transplante, pancitopenia e pré-alta hospitalar, entre setembro de 2013 e setembro de 2014, em um hospital de referência no Brasil para esta modalidade de tratamento. Utilizou-se dois instrumentos internacionais, ambos traduzidos e adaptados para a língua portuguesa (Brasil: Quality of Life Questionnarie-Core 30 e Functional Assessment Cancer Therapy -- Bone Marrow transplantation. Resultados: os pacientes apresentaram queda estatisticamente significativa no domínio social e estabilidade da função emocional ao longo do percurso. Conclusão: o Transplante de Células-Tronco Hematopoéticas altera a função social dos pacientes com câncer hematológico durante a etapa de internamento. Deste modo, o paciente deve receber orientações que contemplem o domínio social, de maneira que este possa ser menos comprometido.

  17. BIOTECNOLOGIAS, SUBJETIVAÇÃO E PSICOLOGIAS: MERCADO DE CÉLULAS-TRONCO DO CORDÃO UMBILICAL

    Directory of Open Access Journals (Sweden)

    Dolores Galindo

    Full Text Available Resumo Esse artigo visa a analisar as práticas de produção da subjetividade engendradas pelo mercado de células-tronco do cordão umbilical, que se constitui por meio da gestão de riscos e precauções do futuro biopolítico, no âmbito da família e da relação pais e filhos. O interesse da psicologia pela inovação biotecnológica pode ser visualizado tanto na problematização crítica realizada pelo campo científico sobre os modos de subjetivações que emergem do acoplamento entre biotécnicas e corpo quanto em seu campo de atuação profissional, por meio de psicoterapias de aconselhamento genético. Nas estratégias biopolíticas de controle e de manipulação das células-tronco do cordão umbilical, evidenciam-se subjetivações que emergem em uma rede complexa de produção tecnobiológica.

  18. Análise do comportamento do hemometabolismo cerebral durante endarterectomia carotídea com pinçamento transitório Análisis del comportamiento del hemometabolismo cerebral durante endarterectomia carotídea con pinzamiento transitorio Analysis of brain hemometabolism behavior during carotid endarterectomy with temporary clamping

    OpenAIRE

    Gastão Fernandes Duval Neto; Augusto H. Niencheski

    2004-01-01

    JUSTIFICATIVA E OBJETIVOS: A endarterectomia carotídea com pinçamento transitório altera a relação entre o fluxo sangüíneo cerebral e a demanda metabólica cerebral de oxigênio, com conseqüente geração de uma tendência a hipóxia oliguêmica ou desacoplamento hemometabólico. O objetivo do presente estudo foi identificar as alterações do hemometabolismo cerebral, avaliados através das alterações da saturação da oxihemoglobina no bulbo da veia jugular interna (SjO2), durante endarterectomia carotí...

  19. Utilização da biofotogrametria para a avaliação da flexibilidade de tronco

    Directory of Open Access Journals (Sweden)

    Andrea Perin

    2012-06-01

    Full Text Available INTRODUÇÃO: a ginástica rítmica (GR é uma modalidade de ginástica que requer alto grau de flexibilidade, em virtude dos movimentos complexos que são requeridos. OBJETIVO: esta pesquisa objetivou comparar o teste de sentar e alcançar (TSA e a técnica de biofotogrametria como indicadores de flexibilidade de tronco, em praticantes iniciantes de GR. METODOLOGIA: a amostra contou com 60 meninas (de cinco a 11 anos de idade de um universo de 110, todas matriculadas em um centro de iniciação esportiva no estado do Paraná. A coleta de dados foi realizada no mês de novembro do ano de 2009. Para a comparação TSA com a biofotogrametria, foram traçados os ângulos de flexão da pelve (WP, flexão da coluna lombar (WC e flexão do total do tronco (WT. RESULTADOS: o resultado médio atingido pelas participantes na escala do TSA foi de 27,75cm. Encontrou-se forte correlação do ângulo WT com o TSA. Por ser uma composição de WC e WP, o WT possibilita uma visualização global da distância do tronco até os membros inferiores quando ocorre a flexão durante o teste. Por isso, as correlações entre os ângulos são boas e significativas. CONCLUSÃO: uma vez que o TSA apresenta alguns fatores intervenientes que podem mascarar o seu resultado, a biofotogrametria é discutida como um teste que permite observar, através de imagens fotográficas e cálculos angulares, dados fidedignos para a mensuração de flexibilidade e compensações musculares não identificadas normalmente.

  20. United Cerebral Palsy

    Science.gov (United States)

    ... your local affiliate Find your local affiliate United Cerebral Palsy United Cerebral Palsy (UCP) is a trusted resource for individuals with Cerebral Palsy and other disabilities and their networks. Individuals with ...

  1. Employees with Cerebral Palsy

    Science.gov (United States)

    ... Resources Home | Accommodation and Compliance Series: Employees with Cerebral Palsy (CP) By Eddie Whidden, MA Preface Introduction Information ... SOAR) at http://AskJAN.org/soar. Information about Cerebral Palsy (CP) What is CP? Cerebral palsy is a ...

  2. Birth Defects: Cerebral Palsy

    Science.gov (United States)

    ... Loss > Birth defects & other health conditions > Cerebral palsy Cerebral palsy E-mail to a friend Please fill in ... this page It's been added to your dashboard . Cerebral palsy (also called CP) is a group of conditions ...

  3. A imunomodulação exercida por receptores do tipo Toll em células-tronco mesenquimais

    OpenAIRE

    Bruno Braga Sangiorgi

    2014-01-01

    Diversos estudos tem demonstrado que as células-tronco mesenquimais (CTM) são imbuídas de uma forte atividade imunossupressora in vitro, no entanto, os resultados de imunoterapias utilizando CTM têm sido variáveis até o momento. Nossa hipótese para tal variação são interações que devem ocorrer entre as CTM e fragmentos de patógenos circulantes nos pacientes, resultando na modulação da atividade imunossupressora. Para avaliar a ocorrência deste fenômeno em CTM de medula óssea, inicialmente foi...

  4. BIOTECNOLOGIAS, SUBJETIVAÇÃO E PSICOLOGIAS: MERCADO DE CÉLULAS-TRONCO DO CORDÃO UMBILICAL

    OpenAIRE

    Galindo, Dolores; Rodrigues, Renata Vilela; Lemos, Flávia Cristina Silveira; Almeida, Leila Cristina da Conceição Santos

    2017-01-01

    Resumo Esse artigo visa a analisar as práticas de produção da subjetividade engendradas pelo mercado de células-tronco do cordão umbilical, que se constitui por meio da gestão de riscos e precauções do futuro biopolítico, no âmbito da família e da relação pais e filhos. O interesse da psicologia pela inovação biotecnológica pode ser visualizado tanto na problematização crítica realizada pelo campo científico sobre os modos de subjetivações que emergem do acoplamento entre biotécnicas e corpo ...

  5. Controle genético das células-tronco humanas cultivadas Genetic control of cultivated human stem cells

    Directory of Open Access Journals (Sweden)

    Spencer L. M. Payão

    2009-05-01

    Full Text Available As células-tronco apresentam uma alta capacidade de autorregeneração, assim como, um potencial de diferenciação em uma variedade de tipos celulares. Estas células podem ser classificadas como embrionárias e adultas. Apesar de apresentar propriedades de células-tronco, as mesenquimais apresentam um certo grau de dificuldade no estabelecimento das culturas, podendo induzir a perda da expressão da enzima responsável pela imortalização ou enzima telomerase. A enzima telomerase é considerada um relógio biológico, um indicador que a senescência celular irá se instalar inevitavelmente. A questão mais atual e intrigante dos pesquisadores é se o suposto potencial de divisão, por um determinado período de tempo, das células-tronco cultivadas poderia levar ao acúmulo de alterações genéticas e epigenéticas, resultando em um processo neoplásico. Daí a importância do papel da citogenética humana no controle e monitoramento das células-tronco cultivadas que serão utilizadas na terapia em seres humanos. Alterações cromossômicas estruturais, tais como deleções, translocações e inversões, representam um mecanismo importante pelo qual as células cancerígenas desenvolvem-se gradualmente, uma vez que estas alterações cromossômicas podem levar a uma expressão anormal de muitos genes, podendo desencadear assim o processo neoplásico.Stem cells have a high capacity of self-regeneration, as well as a potential to differentiate into several cell types. These cells can be classified as embryonic or adult. In spite of having inherent properties of stem cells, mesenchymal cells show a certain degree of difficulty to establish cultures. This might induce a loss of the expression of the telomerase enzyme which is considered to be a biological clock or an indicator of the senescence of the cells. The most current and intriguing question for researchers is whether the presumed division potential of cultivated stem cells, over a

  6. Cerebral palsy

    International Nuclear Information System (INIS)

    Truwit, C.L.; Barkovich, A.J.; Koch, T.; Ferreiro, D.

    1990-01-01

    This paper reviews cranial MR findings in patients with cerebral palsy (CP) to clarify and categorize this disorder. The MR images of 40 patients with clinical CP were retrospectively reviewed. All patients suffered either varying spastic plegias, hypotonicity, or choreoathetosis. Concomitantly, the patients suffered from static encephalopathy, developmental delay, and/or microcephaly. Twenty-four patients were born at or near term, 10 were premature, and incomplete birth histories were available in six. The MR images revealed mild to severe degrees of white matter damage in 24 patients (12 term, nine premature, three unknown)

  7. Relaciones de la grasa visceral y de tronco con el sindrome metabólico

    OpenAIRE

    Fernández Vázquez, Rosalía Asunción

    2016-01-01

    La obesidad central es uno de los componentes que conforman el conjunto de factores del síndrome metabólico. La obesidad central se asocia a una gran incidencia de diabetes tipo 2, resistencia a la insulina, hipertensión arterial y particularmente a las enfermedades cardiovasculares. Las acciones metabólicas del tejido adiposo visceral son por sí solas un factor de riesgo independiente para una serie de alteraciones metabólicas. Objetivos: Los objetivos de la presente tesis han sido estudiar ...

  8. Proteólisis cerebral del péptido amiloide-ß: Relevancia de la enzima degradadora de insulina en la enfermedad de Alzheimer Cerebral proteolysis of amyloid-ß peptide: Relevance of insulin-degrading enzyme in Alzheimer's disease

    Directory of Open Access Journals (Sweden)

    María Celeste Leal

    2009-10-01

    Full Text Available El aumento global de la expectativa de vida convierte a la enfermedad de Alzheimer (EA en un problema creciente. Una de las características distintivas de EA es la acumulación excesiva del péptido amiloide ß (Aß en el cerebro. En los últimos años se ha fortalecido el concepto de que la degradación de Aß por proteasas in situ es un mecanismo importante que previene su acumulación cerebral. Datos bioquímicos y genéticos mostraron que la enzima degradadora de insulina (IDE participa en la homeostasis de Aß e insulina. La expresión y la actividad de IDE están significativamente disminuidas en cerebros con EA comparados con controles de igual edad. Además, IDE se deposita con Aß en placas seniles y vasos, indicando un grosero cambio conformacional producto de distintos mecanismos post-traduccionales. Estas alteraciones en la distribución y actividad de IDE resultan en una insuficiente degradación de Aß e insulina y promueven la formación de oligómeros de Aß y la resistencia a la hormona, procesos que convergen hacia la neurodegeneración. El estudio de los mecanismos de eliminación de Aß cerebral no sólo ayudará a comprender la patogenia de EA sino que permitirá una mejor interpretación de los ensayos clínicos en curso y el desarrollo de nuevas estrategias terapéuticas.The global increase in life expectancy turns Alzheimer's disease (AD into a growing problem. One of the distinctive features of AD is the excessive accumulation of amyloid-ß (Aß peptide in the brain. In recent years, a concept that has gained strength is that degradation of Aß by proteases in situ is an important mechanism that prevents cerebral peptide accumulation. Biochemical and genetic data have shown that insulin-degrading enzyme (IDE participates in Aß and insulin homeostasis. IDE expression and activity are significantly decreased in AD brains compared to age-matched controls. Also, IDE is deposited with Aß in senile plaques and blood vessels

  9. Cerebral Palsy (For Teens)

    Science.gov (United States)

    ... Staying Safe Videos for Educators Search English Español Cerebral Palsy KidsHealth / For Teens / Cerebral Palsy What's in this ... do just what everyone else does. What Is Cerebral Palsy? Cerebral palsy (CP) is a disorder of the ...

  10. Assimetria cerebral e lateralização da linguagem: déficits nucleares na esquizofrenia como indicadores da predisposição genética Asimetría cerebral y lateralización del lenguaje: déficits nucleares en la esquizofrenia como indicadores de predisposición genética Cerebral asymmetry and the lateralization of language: core deficits in schizophrenia as pointers to the genetic predisposition

    Directory of Open Access Journals (Sweden)

    Timothy J. Crow

    2004-08-01

    Full Text Available OBJETIVO: Assimetria cerebral (o torque do frontal direito em relação ao occipital esquerdo é a característica definidora do cérebro humano e, conforme proposto por Broca, o correlato neural putativo da linguagem. Se, conforme sugerido, a esquizofrenia é o preço que Homo sapiens precisa pagar pela linguagem, o torque, juntamente com seus correlatos funcionais, é de fundamental importância. São revisadas recentes evidências obtidas a partir de estudos anatômicos, funcionais e genéticos. ACHADOS RECENTES: Estudos de imagem, post mortem e anatômicos demonstram evidências de uma redução ou reversão de aspectos de assimetria, particularmente no córtex de associação occipitotemporoparietal. Em alguns estudos, há interação com o sexo. Há evidências de que uma alteração no lobo temporal esquerdo é, às vezes, progressiva. Estudos funcionais acrescentam credibilidade ao conceito de que a lateralização da linguagem é reduzida e, em alguns casos, revertida. RESUMO: A dimensão da assimetria se destaca como a variável que pode dar significância às observações entre campos de investigação e que proporciona uma solução para a base genética da psicose. Estudos de gêmeos monozigóticos discordantes têm apresentado fortes indicações de que a variação relevante é epigenética; isso é consistente com a possibilidade de que a variação seja relacionada a alterações estruturais recentes (a transposição duplicativa Xq21.3/Yp dos cromossomos sexuais.OBJETIVO: Asimetría cerebral (el torque del frontal derecho al occipital izquierdo es la característica definidora del cerebro humano y, conforme al propuesto por Broca, el correlato neuronal putativo del lenguaje. Si, conforme a lo sugerido, la esquizofrenia es el precio que el Homo sapiens debe pagar por el lenguaje, el torque, juntamente con sus correlatos funcionales, es de importancia fundamental. Se revisan recientes evidencias obtenidas a partir de estudios

  11. Aplicação do método de análise do tronco a povoamentos de Pinus pinaster na Zona do Pinhal

    OpenAIRE

    Grácio, C.

    1992-01-01

    Apresenta um estudo dendrométrico baseado na aplicação do método de análise do tronco em povoamentos de Pinus pinaster pertencentes a alguns concelhos do distrito de Castelo Branco. É uma abordagem preliminar integrada num projeto em curso na ESA-IPCB sobre "Estudos de Crescimento de e Produção em Povoamentos de Pinus pinaster na Região da Beira Interior".

  12. Dinamometria isocinética de tronco em nadadores de diferentes estilos Isokinetic trunk dynamometry in diferent swimming strokes

    Directory of Open Access Journals (Sweden)

    Leonardo Luiz Barretti Secchi

    2010-01-01

    Full Text Available OBJETIVOS: Comparar a atividade muscular dos músculos flexores e extensores de tronco entre estilos de nado assimétrico e nado simétrico. MÉTODO: Catorze nadadores da elite, velocistas e especialistas em um dos quatro estilos da natação sem história prévia de lesões.. Divididos em dois grupos de sete atletas: 1. Grupo nado assimétrico (GNA: constituído por cinco atletas que nadam o estilo crawl e dois atletas que nadam o estilo costas. 2. Grupo nado simétrico (GNS formado por sete atletas: quatro atletas nadadores no estilo peito e três nadadores no estilo borboleta. Todos foram avaliados no dinamômetro isocinético Cybex 6000. RESULTADOS: O tempo de aceleração na velocidade de 120º/ s do grupo flexor do tronco foi maior no GNS (p=0,054. A potência do grupo extensor nas velocidades de 90 e 120º/ segundo foi maior no GNA que no GNS (p=0,053 e 0,052 respectivamente. Não houve diferença estatística significante nas demais variáveis analisadas. CONCLUSÃO: Os nados assimétricos (crawl e costas proporcionam uma resposta muscular (recrutamento mais eficiente nos grupo dos flexores do tronco, possivelmente pela manutenção constante da contração isométrica dos músculos abdominais.OBJECTIVE: To compare the effect of asymmetric and symmetric swimming strokes on muscle activity of the trunk flexor and extensor muscles. METHODS: Fourteen elite speed swimmers, specialists in one of four swimming styles, all without any history of spinal cord injury, were divided in two groups: 1 asymmetric group, consisting of five athletes specializing in the freestyle stroke and three in the backstroke; and 2 symmetric group, consisting of four athletes specializing in the butterfly stroke and three in the breaststroke. All the swimmers were assessed using a Cybex 6000 isokinetic dynamometer. RESULTS: The acceleration time for the trunk flexor group at a speed of 120º per second was greater in the symmetric group (p=0.054. The power of the

  13. Células-tronco: pesquisa básica em saúde, da ética à panacéia

    Directory of Open Access Journals (Sweden)

    Naara Luna

    2007-12-01

    Full Text Available As terapias com células-tronco estão em fase experimental, mas têm sido representadas na mídia como panacéia que propiciaria a cura de diversas doenças, fato que garantiu a autorização do uso de embriões humanos para pesquisa. As terapias compreendem manipulação de material corporal na bioengenharia de construção de tecidos, o que sugere a representação do corpo humano como fábrica. Este trabalho mapeia os projetos de pesquisa com células-tronco no centro de ciências da saúde de uma instituição de ensino superior, considerando a organização do campo e o sistema de valores subjacente à atividade científica. Analisa-se o discurso de participantes dos projetos, pesquisadores de diversos níveis entrevistados acerca das perspectivas dessas investigações e suas implicações. Constata-se a aprovação dos protocolos com células-tronco adultas e polêmica quanto ao uso de embriões humanos. Buscam-se os fundamentos dessa argumentação e a relação com a organização do campo científico e a formação religiosa dos entrevistados.

  14. Controvérsia científica no telejornalismo brasileiro: um estudo sobre a cobertura das células-tronco no Jornal Nacional

    Directory of Open Access Journals (Sweden)

    Carla Almeida

    2013-11-01

    Full Text Available Em 1998, pesquisas com células-tronco tornaram-se objeto de intensa controvérsia. No Brasil, a polêmica atingiu seu ápice em 2008, quando o Supremo Tribunal Federal iniciou julgamento de ação legal, questionando a nova Lei de Biossegurança por permitir o uso de embriões humanos em pesquisas. Analisa-se aqui a cobertura sobre as células-tronco embrionárias humanas realizada pelo Jornal Nacional . Observa-se tom positivo, marcado pela ênfase nos potenciais benefícios oferecidos pela pesquisa e omissão de limitações e riscos envolvidos. O pequeno índice de sucesso obtido até então como resultado de pesquisas com células-tronco embrionárias e os riscos de elas induzirem a formação de tumores foram omitidos, fazendo crer que a única barreira a novos tratamentos e curas era a legislação.

  15. Cerebral Vasculitis

    Directory of Open Access Journals (Sweden)

    Fariborz Khorvash

    2017-02-01

    Full Text Available Introduction: Vasculitis is an inflammation systems may be involved of blood vessels due to various origins. Vessels of the peripheral and/or central nervous. Vasculitis of the CNS is rare and occurs in the context of systemic diseases or as primary angiitis of the CNS. Epidemiology: The overall incidence of primary vasculitis is about 40/1,000,000 persons [excluding giant cell (temporal arteritis, GCA]. Its incidence increases with age. The incidence of GCA is much higher (around 200/1,000,000 persons in the age group[50 years. Clinical Presentation: Clinical and pathological presentation in CNS vasculitis represents a wide spectrum. Among others, headache, cranial nerve affections, encephalopathy, seizures, psychosis, myelitis, stroke, intracranial haemorrhage and aseptic meningoencephalitis are described. Primary and secondary vasculitides leading more frequently to CNS manifestations are discussed. Primary and secondary Vasculitides: Including Giant Cell (Temporal Arteritis , Takayasu arteritis, Polyarteritis nodosa, Primary angiitis of the CNS, Wegener’s granulomatosis, and Connective tissue diseases, such as systemic lupus erythematosus (SLE, scleroderma, rheumatoid arthritis, mixed connective disease and Sjögren syndrome, are systemic immune-mediated diseases that lead to multiple organ affections. Cerebral Vasculitis: Imaging and Differential Diagnosis: Vasculitides represent a heterogeneous group of inflammatory diseases that affect blood vessel walls of varying calibers (inflammatory vasculopathy. Since the devastating symptoms of CNS vasculitis are at least partially reversible, early diagnosis and appropriate treatment are important. In order to establish a differential diagnosis clinical features, disease progression, age of onset, blood results, as well as CSF examinations have to be taken into consideration. Neuroimaging techniques, such as MRI and DSA, play a central role in the diagnosis and disease monitoring .The diagnostic

  16. O CUIDADO DE ENFERMAGEM EM UNIDADE DE TRANSPLANTE DE CÉLULAS-TRONCO HEMATOPOÉTICAS

    Directory of Open Access Journals (Sweden)

    Kaoana Lima

    2014-01-01

    Full Text Available En la unidad de trasplante de células madre hematopoyéticas cuidados de enfermería se presenta de manera diferente de otros servicios. Un enfoque descriptivo cualitativo tuvo como objetivo identificar las actividades de atención de enfermería de una unidad de trasplante clasificados de acuerdo con una referencia de funcións de la enfermera. La recolección de datos se realizó a través de la observación sistemática y el proceso de datos a través de análisis de contenido. Se identificaron tres posiciones para las enfermeras: clínica, de la gestión y de la visita, siendo la primera una gama más amplia de actividades de atención. El cuidado del mantenimiento de la vida se centran en la atención al paciente y el medio ambiente; le cuidado general técnico incluyen técnicas básicas como el manejo de instrumentos/medicamentos y la evaluación de los pacientes; y los especiales cubren determinadas actividades, como la recolección y la infusión de médula ósea, el cuidado del catéter central y de la transfusión de sangre y de la quimioterapia. Se concluyó que la atención sea integral, especializado y basado en los conocimientos adquiridos por formación complementaria y especialización.

  17. [Cerebral aspergillosis].

    Science.gov (United States)

    Tattevin, P; Jauréguiberry, S; Gangneux, J-P

    2004-05-01

    The brain is almost always a localization of invasive aspergillosis, after hematogenous spread from pulmonary aspergillosis. Brain aspergilosis is not rare and is one of the worst prognosis factors of invasive aspergillosis. The incidence of this severe mycosis is currently on the rise due to the development of major immunosuppressive treatments. Brain aspergillosis is noteworthy for its vascular tropism, leading to infectious cerebral vasculitis, mainly involving thalamoperforating and lenticulostriate arteries, with a high frequency of thalamic or basal nuclei lesions. Extra-neurologic features that suggest this diagnosis are: i) risk factors for invasive aspergillosis (major or prolonged neutropenia, hematologic malignancies, prolonged corticosteroid treatment, bone marrow or solid organ transplant, AIDS); ii) persistent fever not responding to presumptive antibacterial treatment; iii) respiratory signs (brain aspergillosis is associated with pulmonary aspergillosis in 80 to 95 p. 100 of cases). Perspectives. Two recent major improvements in brain aspergillosis management must be outlined: i) for diagnostic purposes, the development of testing for Aspergillus antigenemia (a non-invasive procedure with good diagnostic value for invasive aspergillosis); ii) for therapeutic purposes, the demonstration that voriconazole is better than amphotericin B in terms of clinical response, tolerance and survival, for all types of invasive aspergillosis, the benefit being probably even greater in case of brain aspergillosis because of the good diffusion of voriconazole into the central nervous system. Brain aspergillosis is a severe emerging opportunistic infection for which diagnostic and therapeutic tools have recently improved. Thus, this diagnostic must be suspected early, especially in the immunocompromised patient, in the event of respiratory symptoms and when the brain lesions are localized in the central nuclei and the thalamus.

  18. Dynamic digitized cerebral parenchymography

    International Nuclear Information System (INIS)

    Theron, J.; Alachkar, F.; Nelson, M.; Mazia, D.

    1992-01-01

    Aortic arch injections centred on the head have been performed routinely in patients with cerebral ischaemia. Digital angiograms with modified windowing (low and narrow) have been used. This 'cerebral' arch injection allows much improved analysis of the cerebral parenchymal vascularization, giving better understanding of hemispheric ischaemia and making the decision about revascularization more rational. (orig.)

  19. A problemática do cuidador familiar do portador de acidente vascular cerebral La problemática del cuidador familiar con el portador de accidente cerebral vascular The problematic aspects of the family caregiver of people who suffered strokes

    Directory of Open Access Journals (Sweden)

    Luciene Miranda de Andrade

    2009-03-01

    Full Text Available Objetivou-se identificar a problemática da família de pessoas acometidas de acidente vascular cerebral hospitalizadas e discutir as dificuldades do cuidador familiar para o cuidado no âmbito domiciliar. A amostra constou de 154 famílias de pacientes internados em um hospital da rede pública de saúde, Fortaleza-CE. Conforme os resultados denotam, a maioria dos cuidadores são mulheres, 104 (67,5%; 122 casos (79,2% apresentam comprometimento familiar e alterações na vida diária em 115 dos acompanhantes (74,7%; 150 (97,4% não receberam orientações acerca dos cuidados, mas 143 (92,9% sentem-se seguros para acompanhá-los. O sentimento predominante foi a tristeza, 125 (81,2%, e as dúvidas principais foram: alimentação, 64 (41,6%, administração de medicamentos, 49 (29,9%, e possíveis complicações clínicas após a alta, 49 (29,9%. Estes resultados alertam para o papel do enfermeiro como educador, não somente na prevenção das doenças crônico-degenerativas, mas, também, na orientação aos cuidadores familiares sobre os cuidados dispensados após a alta hospitalar.El objetivo fue identificar la problemática de la familia de personas acometidas de accidente vascular cerebral hospitalizadas y discutir las dificultades del cuidador familiar en el ámbito domiciliar. La muestra fue constituida por 154 familias de pacientes internados en un hospital de la red pública de salud, en Fortaleza, CE. Conforme los resultados denotan, la mayoría de los cuidadores son mujeres, 104 (67,5%, 122 casos (79,2% presentan comprometimiento familiar y alteraciones en la vida diaria en 115 de los acompañantes (74,7%; 150 (97,4% no recibieron orientaciones acerca de los cuidados; sin embargo 143 (92,9% se sienten seguros para acompañarlos. El sentimiento predominante fue la tristeza, 125 (81,2%, y las dudas principales fueron: alimentación, 64 (41,6%, administración de medicamentos, 49 (29,9%, y posibles complicaciones clínicas después del

  20. A Influência da Equoterapia no Desempenho Motor e Alinhamento Postural da Criança com Paralisia Cerebral Espástico-Atetóide – Acompanhamento de um Caso

    Directory of Open Access Journals (Sweden)

    Vivian Valdiviesso

    2015-01-01

    Full Text Available O objetivo desse estudo foi verificar, através de um estudo de caso, os benefícios no desempenho motor e no alinhamento postural de tronco no pré e póstratamento com a equoterapia em uma criança portadora de paralisia cerebral espástico-atetóide. A criança foi avaliada por meio da escala GMFM (Gross Motor Function Measure, sempre antes e após cada sessão de equoterapia, durante 10 sessões, avaliando o desempenho motor da criança. Para a avaliação do alinhamento postural de tronco foram analisados os registros fotográficos das vistas lateral direita, lateral esquerda e posterior antes e após cada sessão, com a criança colocada na postura sentada em um banco sem encosto, os pés apoiados na superfície, verificando o endireitamento de tronco e o posicionamento cefálico. Os resultados obtidos permitiram observar que não houve melhora significativa no desempenho motor, porém com relação ao alinhamento postural verificou-se importante melhora após cada sessão.

  1. Síndrome dos nervos cranianos por glioma do tronco cerebral: Estudo anátomo-clínico de um caso

    Directory of Open Access Journals (Sweden)

    J. Lamartine de Assis

    1945-03-01

    Full Text Available Trata-se de um caso de glioma (astrocitoma fibrilar do segmento hemibulbo-protuberancial esquerdo, e cujo quadro clínico foi dos mais polimorfos, dada a topografia e extensão do tumor. As diversas síndromes clínicas permitiram estabelecer o diagnóstico topográfico, o qual foi totalmente comprovado pela demonstração anátomo-patológica.

  2. Effects of Milrinone continuous intravenous infusion on global cerebral oxygenation and cerebral vasospasm after cerebral aneurysm surgical clipping

    Directory of Open Access Journals (Sweden)

    Mohamed A. Ghanem

    2014-01-01

    Conclusions: Milrinone improved significantly the global cerebral oxygenation and reduced the incidence of cerebral vasospasm during the dangerous period of cerebral spasm after cerebral aneurysm clipping.

  3. Microembolism after cerebral angiography

    International Nuclear Information System (INIS)

    Manaka, Hiroshi; Sakai, Hideki; Nagata, Izumi

    2000-01-01

    Acute microemboli are detected more precisely with the recently developed diffusion-weighted MR imaging (DWI). We happened to obtain 24 DWIs after 350 diagnostic cerebral angiographies in 1999. DWIs after cerebral angiographies showed bright lesions in 7 patients (28%), of whom 6 had no neurological symptoms after cerebral angiography. Seven of the 24 patients had risk factors for arteriosclerosis. Only one patient had embolic events due to angiography. Microemboli related to cerebral angiographies are inevitable in some patients. Most are silent, however, we should investigate the cause of microemboli and should make cerebral angiography safer. (author)

  4. Anestesia e paralisia cerebral Anestesia y parálisis cerebral Anesthesia and cerebral palsy

    Directory of Open Access Journals (Sweden)

    Március Vinícius M Maranhão

    2005-12-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A paralisia cerebral (PC é uma doença não progressiva decorrente de lesão no sistema nervoso central, levando a um comprometimento motor do paciente. O portador de PC freqüentemente é submetido a procedimentos cirúrgicos devido a doenças usuais e situações particulares decorrentes da paralisia cerebral. Foi objetivo deste artigo revisar aspectos da paralisia cerebral de interesse para o anestesiologista, permitindo um adequado manuseio pré, intra e pós-operatório neste tipo de paciente. CONTEÚDO: O artigo aborda aspectos da paralisia cerebral como etiologia, classificação, fatores de risco, fisiopatologia, quadro clínico, diagnóstico, terapêuticas utilizadas bem como avaliação pré-operatória, medicação pré-anestésica, manuseio intra e pós-operatório, analgesia pós-operatória e dor crônica. CONCLUSÕES: O anestesiologista desempenha um papel importante na diminuição da morbidade e mortalidade anestésico-cirúrgica em pacientes portadores de paralisia cerebral. O conhecimento da fisiopatologia dos diferentes tipos de paralisia cerebral bem como das doenças associadas e suas terapêuticas é imprescindível, pois permite ao anestesiologista antecipar e prevenir complicações intra e pós-operatórias neste tipo de paciente.JUSTIFICATIVA Y OBJETIVOS: La parálisis cerebral (PC es una enfermedad no progresiva consecuente de una lesión en el sistema nervioso central, llevando a un comprometimiento motor del paciente. El portador de PC, frecuentemente es sometido a procedimientos quirúrgicos debido a enfermedades usuales y situaciones particulares consecuentes de la parálisis cerebral. El objetivo de este artículo, fue revisar aspectos de la parálisis cerebral de interés para el anestesista, permitiendo un adecuado manoseo pre, intra y posoperatorio en este tipo de paciente. CONTENIDO: El artículo aborda aspectos de la parálisis cerebral como etiología, clasificación, factores de

  5. Carga de trabalho de enfermagem em transplante de células-tronco hematopoiéticas: estudo de coorte

    Directory of Open Access Journals (Sweden)

    Juliana Bastoni da Silva

    2015-12-01

    Full Text Available RESUMO Objetivo Mensurar a carga de trabalho de enfermagem requerida por pacientes submetidos ao transplante de células-tronco hematopoiéticas (TCTH, autólogo e alogênico e analisar as atividades do Nursing Activities Score (NAS executadas pela equipe de enfermagem durante a internação para o TCTH. Método Coorte prospectiva realizada de janeiro/2013 a abril/2014 com 62 pacientes internados na unidade de TCTH de um hospital universitário de Campinas/SP, Brasil. Mediu-se a carga de trabalho por meio do NAS e analisaram-se os dados utilizando os testes Qui-quadrado ou Exato de Fisher, Mann-Whitney e o coeficiente de correlação de Spearman; considerou-se nível de significância de 5%. Resultados A média da carga de trabalho de enfermagem foi de 67,3% (DP 8,2 em pacientes de TCTH autólogo e de 72,4% (DP 13,0 no TCTH alogênico (p=0,1380. O item Monitorização e controles apontou, em mais de 50% das observações, que os pacientes demandaram intensificação deste cuidado, exigindo duas horas ou mais em algum turno de trabalho por motivos de segurança, gravidade ou terapia. Conclusão A carga de trabalho de enfermagem e os itens do NAS mais pontuados refletem a magnitude, complexidade e especificidade dos cuidados demandados pelos pacientes submetidos ao TCTH.

  6. Midazolam por via oral como medicação pré-anestésica em crianças e adolescentes com paralisia cerebral: estudo comparativo das variações do índice bispectral Midazolam por vía oral como medicación preanestésica en niños y adolescentes con parálisis cerebral: estudio comparativo de las variaciones del índice bispectral Oral midazolam as pre-anesthetic medication in children and teenagers with cerebral palsy: a comparative study on the variations of the bispectral index

    Directory of Open Access Journals (Sweden)

    Verônica Vieira da Costa

    2009-02-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: O midazolam é um derivado benzodiazepínico com ação hipnótica e muito utilizado como medicação pré-anestésica em anestesia pediátrica. As crianças com paralisia cerebral (PC também se beneficiam do uso do midazolam, mas seus efeitos são ainda desconhecidos sobre esse grupo de pacientes que apresentam uma série de particularidades, com alterações inclusive no local de ação do midazolam. O objetivo do estudo foi avaliar a ação do midazolam utilizado como medicação pré-anestésica sobre o índice bispectral (EEG-BIS dos pacientes com paralisia cerebral. MÉTODO: Foram avaliados dois grupos de pacientes: um com diagnóstico de PC e outro sem doença do sistema nervoso central (SNC e periférico. Foram registrados valores de EEG-BIS na enfermaria na véspera da operação e no dia da operação, 40 minutos depois da administração de 0,6 mg.kg-1 de midazolam via oral. Foram excluídos pacientes com história de reação paradoxal ao midazolam e pacientes do grupo-controle que estivessem em uso de outra medicação. RESULTADOS: Foram estudados 77 pacientes de ambos os sexos, entre 4 e 18 anos de idade. Não houve diferença entre os valores de EEG-BIS basal entre os grupos estudados. Após o uso do midazolam houve diminuição dos valores do EEG-BIS nos dois grupos estudados, com diferença estatística significativa em cada grupo. Na comparação entre grupos não houve diferença estatística. CONCLUSÕES: O midazolam administrado como medicação pré-anestésica na dose de 0,6 mg.kg-1 diminui os valores basais do EEG-BIS sem caracterizar hipnose e sem diferença estatística nos grupos estudados.JUSTIFICATIVA Y OBJETIVOS: El midazolam es un derivado benzodiazepínico con acción hipnótica y muy utilizado como medicación preanestésica en anestesia pediátrica. Los niños con parálisis cerebral (PC también se benefician del uso del midazolam, pero sus efectos todavía se desconocen sobre ese

  7. O potencial terapêutico das células-tronco em doenças do sistema nervoso = The therapeutic potential of stem cells for nervous system disease

    Directory of Open Access Journals (Sweden)

    Paula, Simone de

    2005-01-01

    Conclusões: Apesar das evidências científicas favoráveis ao uso de células-tronco em doenças neurológicas, consideráveis avanços necessitam ser feitos para compreender a base biológica das células-tronco, incluindo os sinais que determinam sua proliferação e diferenciação, e a caracterização de suas respostas quando transplantadas em uma área encefálica lesada

  8. Capitalização da vida nos bancos de células-tronco do cordão umbilical : interrogantes à psicologia na produção de subjetividade

    OpenAIRE

    Rodrigues, Renata Vilela

    2015-01-01

    As utilizações de biotecnologias direcionadas à manipulação das células-tronco do cordão umbilical parecem se constituir como novas promessas para a cura de algumas patologias existentes e outras que sequer foram identificadas. Tais biotecnologias acabam por viabilizar modos de subjetividades configuradas como precaucionárias, amedrontadas e empresariais, as quais reivindicam para si o cuidado de sua saúde e a otimização da vitalidade. Na biopolítica contemporânea, as células-tronco do sangue...

  9. Anencefalia e morte cerebral (neurológica Anencephaly and brain death

    Directory of Open Access Journals (Sweden)

    Maria Lúcia Fernandes Penna

    2005-06-01

    Full Text Available Vem-se discutindo no país a ética da interrupção da gravidez no caso de fetos anencéfalos. Os opositores ao aborto nesses casos apontam, entre outros argumentos, que não se trata de morte cerebral devido à presença de tronco encefálico. Neste artigo discutimos o conceito de morte cerebral e sua aplicação no que tange à anencefalia. Apontamos alguns aspectos históricos do desenvolvimento desse conceito e a importância de ser considerada a diferença entre conceito e critérios. A morte neurológica é a perda definitiva e total da consciência, enquanto a presença do tronco cerebral é apenas um critério a ser usado nos casos de lesão encefálica em encéfalos antes perfeitos. O conceito de morte cerebral se aplica completamente à ausência de córtex dos anencéfalos, o que sem dúvida permite sua retirada do útero materno. Manter juridicamente a criminalização desse procedimento é uma interferência religiosa no Estado laico e democrático, que impede o exercício de escolha pelos indivíduos segundo seu credo.Brazilian society has recently discussed the ethics of interrupting pregnancy in the case of an anencephalic fetus. In such cases, anti-abortionists contend that anencephaly is not the same as brain death, since a brainstem is present. This article discusses the concept of brain death and its application to the issue of anencephaly. We point to key historical aspects in the development of this concept and the importance of considering the difference between concept and criteria. Neurological death is the definitive and complete loss of consciousness, while the presence of a brainstem is merely a criterion to be used in cases of head injury in previously intact brains. The concept of brain death is totally applicable to the absence of cortex in a fetus with anencephaly, which without a doubt allows such a fetus to be removed from the uterus. To maintain the criminalization of this procedure by legal means represents

  10. Fora da ordem natural: a natureza nos discursos sobre a clonagem e a pesquisa com celulas-tronco em jornais brasileiros

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    Flavia Natercia da Silva Medeiros

    2013-11-01

    Full Text Available Noções de natureza desempenham um papel na cobertura midiática e nas percepções do público sobre as biotecnologias. Neste estudo, fez-se uma análise de discurso das ideias de natureza e natural usadas na cobertura jornalística brasileira da clonagem e das células-tronco. Nos discursos oponentes, as técnicas biotecnológicas foram postas fora da ordem natural e consideradas imorais. Nos discursos defensores, apareceu uma natureza indiferente ou cruel para com o destino humano, ou obstáculo a ser superado; por outro lado, a clonagem e as células-tronco embrionárias foram naturalizadas, e a ovelha Dolly foi antropomorfizada. As representações mitificantes ou transcendentes da natureza não incidem somente sobre as percepções públicas, têm implicações éticas e políticas.

  11. Bases ósseas e musculares dos cortes comerciais do tronco de jacaré-do-Pantanal (Caimanyacare Daudin, 1802

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    Sandra I.S. Figueiredo

    2015-08-01

    Full Text Available Resumo: O consumo de carne de jacaré-do-Pantanal tornou-se uma tendência de mercado e uma cadeia produtiva em ascensão no Estado de Mato Grosso, sendo 28,40% da carne comercializada nos últimos quatro anos oriundos do tronco. Estudos evolutivos, morfofisiológicos, ontogenéticos e tecnológicos foram desenvolvidos, mas não há descrição da musculatura e bases ósseas dos cortes comerciais. Objetivou-se descrever os músculos e correspondentes bases ósseas dos cortes filé de lombo, filé mignon e aparas. Na descrição óssea, utilizaram-se seis carcaças desossadas de exemplares juvenis de jacaré-do-Pantanal, além de um exemplar adulto, obtido por doação após óbito, do Zoológico da UFMT. Os ossos foram macerados em água corrente, clareados e descritos. Para a descrição muscular, 24 exemplares juvenis foram abatidos e esfolados, conservados em freezer e descongelados quando utilizados, sem qualquer fixação. Após a evisceração, foram dissecados em ambos os antímeros. Os músculos semiespinhal, longuíssimo e iliocostal, fixados nas vértebras e costelas torácicas, lombares e sacrais, formam o filé de lombo. O corte aparas é constituído pelos músculos grande dorsal, serrátil, peitoral e abdominais (oblíquo externo, oblíquo interno, transverso e reto, cuja base óssea corresponde as costelas torácicas, lombares e sacrais, a gastrália, o esterno e o epipúbis. Por sua vez, o m. puboisquiofemoral interno cranial, localizado na região sublombar e o m. troncocaudal, da superfície ventral da pelve, compreendem o filé mignon.

  12. Células-tronco hematopoéticas: utilidades e perspectivas Hematopoietic stem cells: uses and perspectives

    Directory of Open Access Journals (Sweden)

    Francisco C. da Silva Junior

    2009-05-01

    Full Text Available As células-tronco hematopoéticas (CTH são células que possuem a capacidade de se autorrenovar e se diferenciar em células especializadas do tecido sanguíneo e do sistema imune. Na medicina, sua importância pode ser evidenciada por seu uso rotineiro do tratamento de doenças onco-hematológicas e imunológicas. A dificuldade de se encontrarem doadores compatíveis de medula óssea tem estimulado a busca por fontes alternativas de CTH, notadamente o sangue de cordão umbilical e placentário (SCUP e o sangue periférico. O número de unidades de SCUP armazenadas no mundo tem sido crescente desde a década de 1990. Em 2004 foi criada a rede BrasilCord, estabelecendo uma rede nacional de bancos de SCUP com o objetivo de aumentar as chances de localização de doadores e ampliar o número de bancos de SCUP no país. A despeito do baixo volume coletado e do maior tempo necessário para regenerar o tecido hematopoético, as CTH de SCUP vêm em alta concentração sanguínea, sua utilização como fonte de CTH para transplante apresenta menor risco de causar doença enxerto versus hospedeiro e possuem maior facilidade de obtenção do que as CTH provenientes de medula óssea.Hematopoietic stem cells (HSC are cells capable of self-renewal and differentiation into specialized blood tissue and immune system cells. In medicine, their importance is evidenced by their routine use in the treatment of onco-hematological and immunologic diseases. The difficulty of finding compatible bone marrow donors has motivated the search for alternative sources of HSC, notably placental/umbilical cord blood (PUCB. The number of PUCB units stored worldwide has been increasing since 1990. In 2004, the BrasilCord network was created, establishing a national network of PUCB banks with the aim of increasing the chances of finding donors and expanding the number of PUCB banks in the country. Despite the small volume collected and the greater amount of time required for the

  13. Maduración cerebral y desarrollo cognoscitivo

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    Mónica Rosselli

    2003-01-01

    Full Text Available La maduración cerebral se correlaciona con muchos de los cambios cognoscitivos y de comportamiento observados durante la infancia y la adolescencia. En este artículo se revisa el concepto de maduración cerebral y su asociación con el desarrollo de la preferencia manual, del lenguaje verbal y de la función ejecutiva en el niño. Se describe el incremento de las arborizaciones dendríticas como el cambio cortical más importante asociado a la adquisición de funciones cognoscitivas complejas. Se asocia la maduración del hemisferio derecho con la conducta emocional y la maduración del hemisferio izquierdo con el lenguaje. La maduración de las áreas prefrontales se correlaciona con el desarrollo de las funciones ejecutivas. Se presentan ejemplos específicos sobre la existencia de asimetría cerebral motriz desde el nacimiento y sobre la lateralización posterior de funciones visuales, auditivas y táctiles. Se analiza la participación cualitativamente diferente de los hemisferios cerebrales en los procesos cognoscitivos durante las distintas etapas del desarrollo del niño. Finalmente, se presentan algunos ejemplos de las secuelas cognoscitivas secundarias a lesiones cerebrales tempranas como un método más para entender la ontogenia de la asimetría cerebral

  14. Maduración cerebral y desarrollo cognoscitivo

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    Mónica Roselli

    2003-05-01

    Full Text Available La maduración cerebral se correlaciona con muchos de los cambios cognoscitivos y de comportamiento observados durante la infancia y la adolescencia. En este artículo se revisa el concepto de maduración cerebral y su asociación con el desarrollo de la preferencia manual, del lenguaje verbal y de la función ejecutiva en el niño. Se describe el incremento de las arborizaciones dendríticas como el cambio cortical más importante asociado a la adquisición de funciones cognoscitivas complejas. Se asocia la maduración del hemisferio derecho con la conducta emocional y la maduración del hemisferio izquierdo con el lenguaje. La maduración de las áreas prefrontales se correlaciona con el desarrollo de las funciones ejecutivas. Se presentan ejemplos específicos sobre la existencia de asimetría cerebral motriz desde el nacimiento y sobre la lateralización posterior de funciones visuales, auditivas y táctiles. Se analiza la participación cualitativamente diferente de los hemisferios cerebrales en los procesos cognoscitivos durante las distintas etapas del desarrollo del niño. Finalmente, se presentan algunos ejemplos de las secuelas cognoscitivas secundarias a lesiones cerebrales tempranas como un método más para entender la ontogenia de la asimetría cerebral.

  15. Ação do anticonvulsivante isolado e associado ao midazolam como medicação pré-anestésica sobre o índice bispectral (BIS em pacientes com paralisa cerebral Acción del antiepiléptico aislado y asociado al midazolam como medicación preanestésica sobre el índice bispectral (BIS en pacientes con parálisis cerebral Effect of isolated anticonvulsant drug use and associated to midazolam as pre-anesthetic medication on the bispectral index (BIS in patients with cerebral palsy

    Directory of Open Access Journals (Sweden)

    Verônica Vieira da Costa

    2010-06-01

    ás utilizado como medicación preanestésica y no se conocen sus interacciones medicamentosas en los pacientes con PC. El objetivo de este estudio fue evaluar el midazolam como medicación preanestésica en el BIS de los pacientes con PC en uso crónico de antiepilépticos. MÉTODO: Se evaluaron tres grupos de pacientes: PC sin uso de antiepilépticos, PC en uso de antiepiléptico y otro grupo sin enfermedad y sin uso de medicaciones (grupo control. En la víspera de la cirugía, con los pacientes despiertos y en decúbito dorsal, fue colocado el monitor del BIS y se registraron los valores basales del BIS. Al día siguiente, 40 minutos antes de la cirugía, los pacientes recibieron 0,6 mg.kg-1 de midazolam por vía oral. Antes del inicio de la anestesia fue realizado el mismo procedimiento para registro del BIS, después del uso del midazolam. RESULTADOS: Fueron estudiados 107 pacientes, 39 pacientes del grupo control y 68 con diagnóstico de PC. De ellos, 17 usaban antiepilépticos. Con relación al valor promedio de BIS después del uso del midazolam, no hubo diferencia entres los pacientes del grupo control y del grupo PC que no tomaban antiepiléptico, mientras que los pacientes que usaban antiepilépticos fueron diferentes (p = 0,003. La posibilidad de disminución del BIS después del uso del midazolam, aumenta de acuerdo con el número de antiepiléptico usado por el paciente. CONCLUSIONES: El uso crónico de antiepiléptico asociado al midazolam vía oral como medicación preanestésica, puede conllevar a la disminución de los valores de BIS configurando niveles profundos de hipnosis.BACKGROUND AND OBJECTIVES: Patients with cerebral palsy (CP frequently receive drugs for the treatment of concomitant diseases, such as seizures. Midazolam is a benzodiazepine with hypnotic action most often used as pre-anesthetic medication and its drug interactions in patients with CP are unknown. The objective of the present study was to evaluate the effect of midazolam as pre

  16. [Cerebral artery thrombosis in pregnancy].

    Science.gov (United States)

    Charco Roca, L M; Ortiz Sanchez, V E; Hernandez Gutierrez-Manchon, O; Quesada Villar, J; Bonmatí García, L; Rubio Postigo, G

    2015-11-01

    A 28 year old woman, ASA I, who, in the final stages of her pregnancy presented with signs of neural deficit that consisted of distortion of the oral commissure, dysphagia, dysarthria, and weakness on the left side of the body. She was diagnosed with thrombosis in a segment of the right middle cerebral artery which led to an ischemic area in the right frontal lobe. Termination of pregnancy and conservative treatment was decided, with good resolution of the symptoms. Copyright © 2014 Sociedad Española de Anestesiología, Reanimación y Terapéutica del Dolor. Publicado por Elsevier España, S.L.U. All rights reserved.

  17. Cerebral venous angioma

    International Nuclear Information System (INIS)

    Inagawa, Tetsuji; Taguchi, Haruyoshi; Kamiya, Kazuko; Yano, Takashi; Nakajima, Reiko

    1984-01-01

    This report presents a 27-year-old male patient who was diagnosed as having cerebral venous angioma in the postero-temporal area by CT scan and cerebral angiography. The patient improved by removing angioma with electrocoagulation of medullary veins. (Namekawa, K.)

  18. El lenguaje del pensamiento

    Directory of Open Access Journals (Sweden)

    Alberto Andreu Marín

    2017-09-01

    Full Text Available ¿Somos capaces de interpretar las señales eléctricas que genera nuestro cerebro cuando estamos pensando? Lo que a priori parece ciencia ficción comienza a ser factible gracias a los avances recientes en técnicas de registro cerebral y en aprendizaje automático. Nos encontramos en el inicio de una nueva era en lo que al conocimiento del cerebro se refiere.

  19. Unilateral cerebral polymicrogyria with ipsilateral cerebral hemiatrophy

    Energy Technology Data Exchange (ETDEWEB)

    Hayakawa, Katsumi [Department of Radiology, Kyoto City Hospital, 1-2 Higashi-Takada-cho, Mibu, Nakagyo-ku, 604-8845 Kyoto (Japan); Kanda, Toyoko; Yamori, Yuriko [Department of Pediatric Neurology, St. Joseph Hospital for Handicapped Children, 603-8323 Kyoto (Japan)

    2002-10-01

    We evaluated six children in whom MR imaging showed unilateral cerebral polymicrogyria associated with ipsilateral cerebral atrophy and ipsilateral brain stem atrophy. The aim of this study was to clarify whether this disorder based on neuroimaging constitutes a new homogeneous clinical entity. The subjects were six children whose ages at the time of MR imaging ranged from 8 months to 11 years. Their clinical and MR features were analyzed. All of the children were born between 38 and 42 weeks gestation, without any significant perinatal events. Spastic hemiplegia and epilepsy were observed in all of the patients, and mental retardation was observed in four. The MR findings included unilateral cerebral polymicrogyria associated with ipsilateral cerebral hemiatrophy and ipsilateral brain stem atrophy in all patients. The ipsilateral sylvian fissure was hypoplastic in four patients. These patients showed relatively homogeneous clinical and neuroimaging features. Although the additional clinical features varied according to the site and the extent affected by the polymicrogyria, this disorder could constitute a new relatively homogeneous clinical entity. (orig.)

  20. Unilateral cerebral polymicrogyria with ipsilateral cerebral hemiatrophy

    International Nuclear Information System (INIS)

    Hayakawa, Katsumi; Kanda, Toyoko; Yamori, Yuriko

    2002-01-01

    We evaluated six children in whom MR imaging showed unilateral cerebral polymicrogyria associated with ipsilateral cerebral atrophy and ipsilateral brain stem atrophy. The aim of this study was to clarify whether this disorder based on neuroimaging constitutes a new homogeneous clinical entity. The subjects were six children whose ages at the time of MR imaging ranged from 8 months to 11 years. Their clinical and MR features were analyzed. All of the children were born between 38 and 42 weeks gestation, without any significant perinatal events. Spastic hemiplegia and epilepsy were observed in all of the patients, and mental retardation was observed in four. The MR findings included unilateral cerebral polymicrogyria associated with ipsilateral cerebral hemiatrophy and ipsilateral brain stem atrophy in all patients. The ipsilateral sylvian fissure was hypoplastic in four patients. These patients showed relatively homogeneous clinical and neuroimaging features. Although the additional clinical features varied according to the site and the extent affected by the polymicrogyria, this disorder could constitute a new relatively homogeneous clinical entity. (orig.)

  1. Transplante de células-tronco hematopoéticas em linfoma Hodgkin Stem cell transplantation in Hodgkin lymphoma

    Directory of Open Access Journals (Sweden)

    Rosane I. Bittencourt

    2010-05-01

    Full Text Available O linfoma Hodgkin(LH é uma malignidade hematológica que conta com um armamentário terapêutico selecionado de acordo com o estadiamento e a classificação prognóstica de cada doente. A sobrevida dos pacientes tratados para o LH clássico vem aumentando significativamente, com taxas de cura entre 80%-85%. Entretanto, 20%-25% são refratários aos tratamentos iniciais e cerca de 30% recaem após ter alcançado resposta completa. Os pacientes considerados com falha à terapia de primeira linha ainda têm uma segunda chance de cura se apresentarem quimiossensibilidade aos esquemas de salvamento, seguido por uma das modalidades de transplante de células-tronco hematopoéticas (TCTH. O TCTH autólogo representa uma estratégia atrativa para os pacientes com LH que falham ao tratamento convencional de primeira linha. Os resultados em termos de sobrevidas livre de doença e global são superiores aos esquemas de salvamento com quimioterapia convencional. Este procedimento tem finalidade curativa para 50% dos pacientes em segunda remissão quimiossensíveis e pode levar a remissões duráveis naqueles com mais de duas linhas de terapia. Atualmente, o TCTH alogênico, basicamente com condicionamento de intensidade reduzida (RIC, está indicado em pacientes com recaída precoce após o TCTH autólogo ou em pacientes bastante jovens com refratariedade a mais de duas linhas de tratamento convencional.Hodgkin's Lymphoma is a hematologic malignancy with a wide range of therapeutic options that must be chosen according to the stage and the prognostic classification of each patient. The overall survival of patients treated for classic Hodgkin's Lymphoma is increasing significantly, with current cure rates being between 80% and 85%. Nevertheless, 20% to 25% are refractory to the initial treatment and about 30% relapse after having reached a complete response. Patients that have failed standard therapy still have a second chance of cure if they present

  2. Arquitectura contemporánea en rollizo en las regiones del Bío-Bío y La Araucanía

    Directory of Open Access Journals (Sweden)

    Rodrigo Villalobos P.

    1997-05-01

    Full Text Available En la regiones del Bío-Bío y de la Araucanía se ha observado en el transcurso de los últimos años, un notorio desarrollo de arquitectura en rollizo de pino. Hasta ahora la historia arquitectónica del sur del país no había mostrado un masivo empleo del rollizo y los ejemplos existentes eran más bien aislados, como el caso del Fuerte Bulnes en la Patagonia Austral o la arquitectura tradicional mapuche en que los troncos de madera fueron utilizados como estructura. A diferencia de los Estados Unidos y Canadá, en que apareció arquitectura en rollizo desde los tiempos de la conquista del Oeste.

  3. Complicações pulmonares não infecciosas após transplante de células-tronco hematopoiéticas

    Directory of Open Access Journals (Sweden)

    Eliane Viana Mancuzo

    2010-09-01

    Full Text Available Resumo: As complicações pulmonares constituem importante causa de morbidade e mortalidade após o transplante de células-tronco hematopoiéticas (TCTH ocorrendo em cerca de 30 a 60% dos receptores. O avanço na profilaxia e tratamento de complicações infecciosas tem aumentado de forma significativa a parcela de complicações pulmonares não infecciosas. O diagnóstico e o tratamento precoce destas complicações podem mudar o prognóstico dos receptores de transplante de células-tronco hematopoéticas. O objectivo deste estudo é rever as principais complicações não infecciosas associadas ao TCTH desde a realização do primeiro transplante de medula óssea em 1957.Foi realizada uma revisão sistemática da literatura utilizando-se a estratégia PICO para a construção das perguntas. Os descritores transplante de células-tronco hematopoiéticas, complicações pulmonares não infecciosas, revisão sistemática, em português e seus correspondentes em inglês, foram utilizados para acesso às seguintes bases de dados: MEDLINE, EBM, EMBASE, COCRANE LIBRARY, LILACS e SciELO. Nesta revisão foram identificados 263 trabalhos. Destes, 30 foram seleccionados para serem analisados na íntegra. As complicações pulmonares não infecciosas mais frequentemente descritas foram: bronquiolite obliterante, bronquiolite obliterante com pneumonia em organização, edema pulmonar, síndroma da pneumonia idiopática, síndroma da toxicidade pulmonar por droga, hemorragia alveolar difusa, síndroma do enxerto e trombo citolítico pulmonar.Rev Port Pneumol 2010; XVI (5: 815-828 Abstract: Pulmonary complications are important cause of mortality and morbidity after hematopoietic stem cell transplantation, in 30% to 60% of the patients. Improvements in prophylaxis and treatment of infectious complications have been increasing the rate of non-infectious complications. Early diagnosis and treatment of those complications can significantly change the

  4. Transplante de células-tronco hematopoéticas (TCTH em doenças falciformes Hematopoietic stem cell transplantation in sickle cell anemia

    Directory of Open Access Journals (Sweden)

    Fabiano Pieroni

    2007-09-01

    Full Text Available O único tratamento curativo para pacientes com doença falciforme é o transplante de células tronco hematopoéticas (TCTH. Neste artigo sumarizamos os resultados do TCTH em pacientes falciformes publicados na literatura e a experiência brasileira. As indicações atuais para o TCTH nestes pacientes serão discutidas.The only curative treatment approach for patients with sickle cell anemia is allogeneic stem cell transplantation. In this article we will review the published data about stem cell transplantation in patients with sickle cell disease and the small Brazilian experience in this field. The possible indications for stem cell patients will be discussed.

  5. Atividade eletromiográfica dos extensores de tronco durante manuseio pelo Método Neuroevolutivo Bobath

    OpenAIRE

    Pagnussat,Aline de Souza; Simon,Anelise de Saldanha; Santos,Camila Grazziotin dos; Postal,Morgana; Manacero,Sonia; Ramos,Renata Raab

    2013-01-01

    INTRODUÇÃO: Paralisia cerebral é um distúrbio caracterizado por alterações no desenvolvimento da atividade, do movimento e da postura. O Conceito Neuroevolutivo Bobath é um método utilizado na reabilitação neuropediátrica, fundamentando-se na facilitação da aquisição de habilidades sensório-motoras de acordo com a sequência de desenvolvimento neuropsicomotor normal. OBJETIVO: Verificar atividade eletromiográfica de músculos envolvidos no controle cervical nos planos frontal, sagital e transve...

  6. Alterações na audiometria de tronco encefálico em mulheres adultas com hipotireoidismo subclínico

    Directory of Open Access Journals (Sweden)

    Figueiredo Lília Cristiane M. S.

    2003-01-01

    Full Text Available A correlação entre perda auditiva e distúrbios adquiridos da glândula tireóide tem sido tema de interesse há muito tempo na Medicina. Diversos trabalhos foram dedicados à investigação audiológica de pacientes com hipotireoidismo, mas poucos autores abordaram a forma subclínica desta doença utilizando a audiometria de tronco encefálico (ABR. OBJETIVO: Avaliar se ocorrem ou não alterações na ABR em mulheres normoacúsicas com hipotireoidismo subclínico não tratado quando comparadas a mulheres sem doença endócrina. DESENHO DO ESTUDO: Prospectivo clínico. MATERIAL E MÉTODO: Uma série de 16 pacientes foi analisada com ABR e seus resultados foram relacionados aos do grupo-controle análogo em sexo e idade. RESULTADOS: Houve diferença significativa (p<0,05 nas médias das latências absolutas das ondas III (p=0,039 e V (p=0,006 e dos intervalos interpicos I-III (p=0,017, III-V (p=0,044 e I-V (p=0,002 entre os dois grupos, mostrando que as medidas destas latências foram significativamente maiores no grupo do hipotireoidismo. CONCLUSÃO: Na condição de hipotireoidismo subclínico, antes mesmo de haver qualquer anormalidade nos limiares psicoacústicos, já poderá ser observado comprometimento na condução nervosa ao longo das vias auditivas no tronco encefálico, como demonstrado pela avaliação com ABR.

  7. Cerebral Palsy (For Parents)

    Science.gov (United States)

    ... Going to an Occupational Therapist Scoliosis In the Band: Jens' Story Cerebral ... KidsHealth® is for educational purposes only. For specific medical advice, diagnoses, and treatment, consult your doctor. © 1995- ...

  8. Cerebral Contusions and Lacerations

    Science.gov (United States)

    ... Contusions and Lacerations Concussion Diffuse Axonal Injury Intracranial Hematomas Skull Fracture Sports-Related Concussion Cerebral contusions are ... Contusions and Lacerations Concussion Diffuse Axonal Injury Intracranial Hematomas Skull Fracture Sports-Related Concussion NOTE: This is ...

  9. Cerebral venous angiomas

    International Nuclear Information System (INIS)

    Agnoli, A.L.; Hildebrandt, G.

    1985-01-01

    Clinical symptoms and radiological signs in 15 patients with cerebral venous malformations are presented and the diagnostic problems discussed. The circulation time in combination with cerebral malformations and angiomas of the scalp are described. CT findings in cases of venous malformations of the brain stem are evaluated. Spot-like enhancement, as well as sharply demarcated round shaped enhancement are characteristic for venous angiomas. Cavernous angiomas usually present as homogenous or inhomogenous round shaped enhanced areas. (Author)

  10. Cerebral cartography and connectomics

    OpenAIRE

    Sporns, Olaf

    2015-01-01

    Cerebral cartography and connectomics pursue similar goals in attempting to create maps that can inform our understanding of the structural and functional organization of the cortex. Connectome maps explicitly aim at representing the brain as a complex network, a collection of nodes and their interconnecting edges. This article reflects on some of the challenges that currently arise in the intersection of cerebral cartography and connectomics. Principal challenges concern the temporal dynamic...

  11. A importância do uso das células tronco para a saúde pública The importance of the use of stem cells for public health

    Directory of Open Access Journals (Sweden)

    Lygia da Veiga Pereira

    2008-02-01

    Full Text Available Em 1999, as células-tronco foram eleitas "Scientific Breakthrough of the Year" (avanço científico do ano pela revista Science¹. Naquele ano, foi demonstrado que células-tronco de tecidos adultos mantinham a capacidade de se diferenciar em outros tipos de tecidos. No ano anterior, as primeiras linhagens de células-tronco embrionárias humanas foram estabelecidas. Desde então, o número de artigos científicos sobre células-tronco vem crescendo exponencialmente, onde novos paradigmas são estabelecidos. Neste artigo, farei uma revisão da área de células-tronco com um foco especial em seu uso como agente terapêutico em doenças comuns como diabetes e cardiopatias. As células-tronco serão tratadas em dois grupos distintos: as embrionárias e as adultas. Enquanto o potencial de diferenciação das primeiras está bem caracterizado em camundongos e em humanos, seu uso em terapia celular e em pesquisa tem sido dificultado por questões de histocompatibilidade, segurança e ética. Em contraste, células-tronco adultas não apresentam estes empecilhos, apesar da extensão de sua plasticidade ainda estar sob investigação. Mesmo assim, diversos testes clínicos em humanos estão em andamento utilizando células-tronco adultas, principalmente derivadas da medula óssea. Discutirei ainda a importância de se trabalhar com as duas classes de células-tronco humanas de forma a se cumprir suas promessas terapêuticas.Stem cells were elected 'Breakthrough of the Year' by Science¹ magazine in 1999, having shown that stem cells from adult tissues retained the ability to differentiate into other tissue types. During the previous year, the first human embryo stem cell lines were established. Since then, the number of scientific papers on stem cells has been increasing exponentially, establishing new paradigms that are rapidly challenged by subsequent experiments. This paper reviews the stem cell research field, divided into two groups: embryo and

  12. Nanomedicine in cerebral palsy

    Science.gov (United States)

    Balakrishnan, Bindu; Nance, Elizabeth; Johnston, Michael V; Kannan, Rangaramanujam; Kannan, Sujatha

    2013-01-01

    Cerebral palsy is a chronic childhood disorder that can have diverse etiologies. Injury to the developing brain that occurs either in utero or soon after birth can result in the motor, sensory, and cognitive deficits seen in cerebral palsy. Although the etiologies for cerebral palsy are variable, neuroinflammation plays a key role in the pathophysiology of the brain injury irrespective of the etiology. Currently, there is no effective cure for cerebral palsy. Nanomedicine offers a new frontier in the development of therapies for prevention and treatment of brain injury resulting in cerebral palsy. Nanomaterials such as dendrimers provide opportunities for the targeted delivery of multiple drugs that can mitigate several pathways involved in injury and can be delivered specifically to the cells that are responsible for neuroinflammation and injury. These materials also offer the opportunity to deliver agents that would promote repair and regeneration in the brain, resulting not only in attenuation of injury, but also enabling normal growth. In this review, the current advances in nanotechnology for treatment of brain injury are discussed with specific relevance to cerebral palsy. Future directions that would facilitate clinical translation in neonates and children are also addressed. PMID:24204146

  13. Ictus cerebral e ingreso en el hogar

    Directory of Open Access Journals (Sweden)

    Clara Raisa Vera Miyar

    2001-12-01

    Full Text Available Se realizó un estudio descriptivo prospectivo en pacientes que egresaron con el diagnóstico de ictus cerebral de la unidad de cuidados intermedios de adultos del hospital Clinicoquirúrgico Docente "Mártires del 9 de abril" de Sagua la Grande, en el período comprendido de enero de 1999 a enero de 2000. Fueron ingresados en el hogar después de encontrarse estabilizados, se analizaron datos generales y epidemiológicos, y se concluyó que en la muestra existió un predominio de ictus isquémico. La hipertensión arterial, el hábito de fumar y los ictus previos, fueron los factores de riesgo más frecuentes, y las parálisis y los trastornos del lenguaje y esfinterianos los síntomas invalidantes predominantes al ser egresados del hospital. No hubo diferencias significativas entre los isquémicos y los hemorrágicos, con una evolución satisfactoria en su mayoría al ser ingresados en el hogar y con un ahorro de $ 10 932.A descriptive and prospective study was conducted among patients with the diagnosis of cerebral ictus that were discharged from the unit of intermediate care of "Mártires del 9 de Abril" Clinical and Surgical Teaching Hospital from January, 1999, to January, 2000. They were admitted at home after being stabilized. General and epidemiological data were analyzed and it was concluded that there was a predominance of ischemic ictus in the sample. Arterial hypertension, smoking and previous ictus were the most common risk factors whereas paralysis and speech and sphincter disorders were the prevailing disabling symptoms on discharge. There were no significant differences between the ischemic and the hemorrhagic ictus. A satisfactory evolution was observed in most of the patients on being admitted at home, which represented a saving of $10 932.

  14. Cerebral palsy and congenital malformations

    DEFF Research Database (Denmark)

    Garne, Ester; Dolk, Helen; Krägeloh-Mann, Inge

    2007-01-01

    AIM: To determine the proportion of children with cerebral palsy (CP) who have cerebral and non-cerebral congenital malformations. METHODS: Data from 11 CP registries contributing to the European Cerebral Palsy Database (SCPE), for children born in the period 1976-1996. The malformations were...... classified as recognized syndromes, chromosomal anomalies, cerebral malformations or non-cerebral malformations. Prevalence of malformations was compared to published data on livebirths from a European database of congenital malformations (EUROCAT). RESULTS: Overall 547 out of 4584 children (11.9%) with CP...... were reported to have a congenital malformation. The majority (8.6% of all children) were diagnosed with a cerebral malformation. The most frequent types of cerebral malformations were microcephaly and hydrocephaly. Non-cerebral malformations were present in 97 CP children and in further 14 CP children...

  15. Morfología Sagital del Raquis en Palistas Jóvenes de Alto Nivel

    OpenAIRE

    Muyor, José M; Alacid, Fernando; López-Miñarro, Pedro A

    2011-01-01

    El objetivo fue valorar la morfología raquídea del raquis torácico y lumbar en piragüistas de la modalidad de kayak de categoría cadete. A un total de 66 kayakistas de aguas tranquilas, 36 varones y 30 mujeres de categoría cadete (media de edad 16,22 ± 0,80 años), se les evaluó mediante un Spinal Mouse la morfología sagital del raquis torácico y lumbar en bipedestación, decúbito prono y en flexión máxima del tronco en sedentación con rodillas extendidas (test sit-and-reach). La cifosis toráci...

  16. Nanomedicine in cerebral palsy

    Directory of Open Access Journals (Sweden)

    Balakrishnan B

    2013-11-01

    Full Text Available Bindu Balakrishnan,1 Elizabeth Nance,1 Michael V Johnston,2 Rangaramanujam Kannan,3 Sujatha Kannan1 1Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University; Baltimore, MD, USA; 2Department of Neurology and Pediatrics, Kennedy Krieger Institute, Baltimore, MD, USA; 3Department of Ophthalmology, Center for Nanomedicine, Johns Hopkins University, Baltimore, MD, USA Abstract: Cerebral palsy is a chronic childhood disorder that can have diverse etiologies. Injury to the developing brain that occurs either in utero or soon after birth can result in the motor, sensory, and cognitive deficits seen in cerebral palsy. Although the etiologies for cerebral palsy are variable, neuroinflammation plays a key role in the pathophysiology of the brain injury irrespective of the etiology. Currently, there is no effective cure for cerebral palsy. Nanomedicine offers a new frontier in the development of therapies for prevention and treatment of brain injury resulting in cerebral palsy. Nanomaterials such as dendrimers provide opportunities for the targeted delivery of multiple drugs that can mitigate several pathways involved in injury and can be delivered specifically to the cells that are responsible for neuroinflammation and injury. These materials also offer the opportunity to deliver agents that would promote repair and regeneration in the brain, resulting not only in attenuation of injury, but also enabling normal growth. In this review, the current advances in nanotechnology for treatment of brain injury are discussed with specific relevance to cerebral palsy. Future directions that would facilitate clinical translation in neonates and children are also addressed. Keywords: dendrimer, cerebral palsy, neuroinflammation, nanoparticle, neonatal brain injury, G4OH-PAMAM

  17. Monitoring of cerebral haemodynamics in newborn infants

    DEFF Research Database (Denmark)

    Liem, K Djien; Greisen, Gorm

    2010-01-01

    The most important cerebrovascular injuries in newborn infants, particularly in preterm infants, are cerebral haemorrhage and ischemic injury. The typical cerebral vascular anatomy and the disturbance of cerebral haemodynamics play important roles in the pathophysiology. The term 'cerebral haemod...

  18. A propósito del síndrome de Ohtahara

    Directory of Open Access Journals (Sweden)

    Albia J. Pozo Alonso

    2003-12-01

    Full Text Available El síndrome de Ohtahara constituye una encefalopatía epiléptica dependiente de la edad que presenta un origen variado. El comienzo de las manifestaciones clínicas ocurre en la mayoría de los pacientes en el período neonatal. Los espasmos tónicos (hasta 10 seg de duración, agrupados en series o también esporádicos, constituyen la forma más frecuente de presentación. Las crisis parciales se observan en aproximadamente la tercera parte de los pacientes. El sexo que predomina es el masculino. La característica del electroencefalograma interictal es la presencia de oleadas generalizadas de gran amplitud, que alternan con fases de supresión de la actividad eléctrica cerebral. El objetivo principal de este trabajo es llamar la atención de la existencia de esta entidad en la etapa neonatal y precoz de la lactancia. Se muestra un paciente del sexo masculino de 16 días de edad que comenzó con espasmos tónicos, asociados a hipotonía severa de cuello y de tronco, con hipertonía de los miembros y un electroencefalograma compatible con esta entidad. La tomografía axial computadorizada de cráneo mostró signos de atrofia cerebral de predominio cortical. La respuesta al tratamiento fue desfavorable. Este síndrome presenta un pronóstico muy severo y las crisis son muy resistentes al tratamiento.Ohtahara's syndrome is an epyleptic encephalopathy depending on age that present a varied origin. The clinical manifestations appear mostly during the neonatal period. The tonic spasms (up to 10 sec of duration, which are grouped in series or sporadic are the most common form of presentation. Partial crises are observed in approximately the third part of the patients. There is a prevalence of males. The characteristic of the interictal electroencephalogram is the presence of generalized waves of great amplitude alternating with phases of suppression of the brain electrical activity. The main objective of this paper is to call the attention about

  19. Análise radiográfica comparativa do trunk shift da escoliose idiopática do adolescente entre ganchos, híbrida e parafusos Análisis comparativo radiológico del trunk shift de la escoliosis idiopática del adolescente entre los ganchos, tornillos e híbridas Comparative radiographic analysis of trunk shift of adolescent idiopathic scoliosis between hooks, screws and hybrid

    Directory of Open Access Journals (Sweden)

    Cesar Daniel Macedo

    2011-01-01

    Full Text Available OBJETIVOS: Analisar radiograficamente a descompensação lateral do tronco (trunk shift em pacientes com escoliose idiopática do adolescente submetidos à artrodese seletiva da curva torácica principal nas três diferentes técnicas de gancho, híbridas e parafusos. MÉTODOS: Avaliadas e comparadas retrospectivamente radiografias ântero-posteriores no período pré-operatório, pós-operatório imediato e no seguimento mínimo de um ano em nove pacientes com ganchos, 13 híbridas e 13 parafusos, quanto à mensuração do trunk shift e ângulo de Cobb entre essas três diferentes técnicas de instrumentação. RESULTADOS: As médias no período pré-operatório imediato da descompensação do tronco para direita foram de 16,7 mm para ganchos, 13,2 mm para híbridas, 27,3 mm para parafusos. No pós-operatório imediato foram de -16 mm para ganchos, -12,8 mm para híbridas, -10,7 mm para parafusos, com uma correção no seguimento de um ano para -9,6 mm para ganchos, -11,8 mm para híbridas e -10,7 mm para parafusos ocorrendo o deslocamento do tronco para esquerda. Todos os casos com uso de somente parafusos pediculares apresentaram trunk shift menor que 20 mm. Verificamos desequilíbrio no grupo de ganchos em um paciente (11,11% e de híbridas em dois pacientes (15,38%. CONCLUSÃO: Não houve diferença significativa na descompensação lateral do tronco entre o uso das três técnicas de instrumentação.OBJETIVOS: Analizar, radiográficamente, la descompensación del tronco (trunk shift: desplazamiento del tronco en pacientes con escoliosis idiopática del adolescente sometidas a artrodesis selectivas de la curva torácica primaria en las tres diferentes técnicas: ganchos, híbridas y tornillos. MÉTODOS: Evaluación y comparación retrospectiva de las radiografías anteroposteriores en los períodos preoperatorio, posoperatorio y d el seguimiento de, al menos. 1 año en 9 pacientes con ganchos, 13 híbridas y 13 con tornillos, cuanto a la

  20. Neurological complications of hematopoietic stem cell transplantation (HSCT: a retrospective study in a HSCT center in Brazil Complicações neurológicas do transplante de células tronco hematopoiéticas (TCTH: estudo retrospectivo em um centro de TCTH no Brasil

    Directory of Open Access Journals (Sweden)

    Hélio A.G. Teive

    2008-01-01

    Full Text Available We present the neurological complications evaluated in a series of 1000 patients who underwent hematopoietic stem cell transplantation (HSCT. Central nervous system (CNS neurological complications, particularly brain hemorrhages, were the most common, followed by seizures and CNS infections. An unusual neurological complication was Wernicke's encephalopathy. Less frequent neurological complications were metabolic encephalopathy, neuroleptic malignant syndrome, reversible posterior leukoencephalopathy syndrome, brain infarct and movement disorders. The most common neurological complication of the peripheral nervous system was herpes zoster radiculopathy, while peripheral neuropathies, inflammatory myopathy and myotonia were very rarely found.Apresentamos as complicações neurológicas avaliadas em uma série de 1000 pacientes submetidos ao transplante de células tronco hematopoiéticas (TCTH. As complicações neurológicas do sistema nervoso central foram as mais encontradas, particularmente as hemorragias encefálicas, seguidas por crises convulsivas e por infecções. Uma complicação peculiar foi a encefalopatia de Wernicke. Menos freqüentemente foram encontrados casos de encefalopatia metabólica, síndrome maligna neuroléptica, leucoencefalopatia posterior reversível, infarto cerebral e os distúrbios do movimento. Entre as complicações neurológicas do sistema nervoso periférico a mais encontrada foi a radiculopatia pelo herpes zoster, enquanto que raramente se observaram casos de polineuropatias periféricas, miopatia inflamatória e de miotonia.

  1. Neuroimaging of cerebral vasculitis

    International Nuclear Information System (INIS)

    Wengenroth, M.; Saam, T.; Haehnel, S.

    2016-01-01

    Cerebral vasculitis can have a variety of origins. Furthermore, there are no vasculitis-specific symptoms or imaging signs and vasculitis of the CNS can mimic many other neurological diseases, which require different treatment approaches. Thus, the clinical and radiological diagnosis of cerebral vasculitis is challenging. Magnetic resonance imaging (MRI) and MR angiography (MRA) should be the radiological imaging methods of choice to assess the degree of parenchymal damage and to detect vessel wall changes. If the results are unclear digital subtraction angiography (DSA) should be pursued in order to also detect changes in medium sized vessels. Vasculitis of small vessels cannot be detected by vascular imaging and requires brain or leptomeningeal biopsy. In this review we present the current diagnostic approach and a variety of imaging findings in cerebral vasculitis and discuss the main radiological differential diagnoses. (orig.) [de

  2. Duplicated middle cerebral artery

    Science.gov (United States)

    Perez, Jesus; Machado, Calixto; Scherle, Claudio; Hierro, Daniel

    2009-01-01

    Duplicated middle cerebral artery (DMCA) is an anomalous vessel arising from the internal carotid artery. The incidence DMCA is relatively law, and an association between this anomaly and cerebral aneurysms has been documented. There is a controversy whether DMCA may have perforating arteries. This is an important fact to consider in aneurysm surgery. We report the case of a 34-year-old black woman who suffered a subarachnoid hemorrhage and the angiography a left DMCA, and an aneurysm in an inferior branch of the main MCA. The DMCA and the MCA had perforating arteries. The aneurysm was clipped without complications. The observation of perforating arteries in our patient confirms that the DMCA may have perforating arteries. This is very important to be considered in cerebral aneurysms surgery. Moreover, the DMCA may potentially serve as a collateral blood supply to the MCA territory in cases of MCA occlusion. PMID:22140405

  3. Diaschisis with cerebral infarction

    Energy Technology Data Exchange (ETDEWEB)

    Slater, R.; Reivich, M.; Goldberg, H.; Banka, R.; Greenberg, J.

    1977-01-01

    Fifteen patients admitted to Philadelphia General Hospital with acute strokes had repeated measurements of cerebral blood flow measured by the /sup 133/X inhalation method. A progressive decline in cerebral blood flow in both hemispheres was observed during the first week after infarction in twelve of these patients. This decline could be partially explained by loss of autoregulation, but could not be correlated with level of consciousness, clinical status of PCO2. This progressive decline in flow in the non-ischemic hemisphere indicates a process more complex than a simple destruction of axonal afferants to neurons as implied by the term diaschisis. The flow changes in the non-ischemic hemisphere are likely caused by a combination of the immediate effects of decreased neuronal stimulation modified by loss of autoregulation, release of vasoactive substances, cerebral edema, and other factors.

  4. Cerebral hemodynamics in migraine

    DEFF Research Database (Denmark)

    Hachinski, V C; Olesen, Jes; Norris, J W

    1977-01-01

    Clinical and angiographic findings in migraine are briefly reviewed in relation to cerebral hemodynamic changes shown by regional cerebral blood flow (rCBF) studies. Three cases of migraine studied by the intracarotid xenon 133 method during attacks are reported. In classic migraine, with typical...... prodromal symptoms, a decrease in cerebral blood flow has been demonstrated during the aura. Occasionally, this flow decrease persists during the headache phase. In common migraine, where such prodromata are not seen, a flow decrease has not been demonstrated. During the headache phase of both types...... of migraine, rCBF has usually been found to be normal or in the high range of normal values. The high values may represent postischemic hyperemia, but are probably more frequently secondary to arousal caused by pain. Thus, during the headache phase rCBF may be subnormal, normal or high. These findings do...

  5. Cerebral fat embolism

    International Nuclear Information System (INIS)

    Sakamoto, Toshihisa; Sawada, Yusuke; Yukioka, Tetsuo; Nishide, Kazuyuki; Yoshioka, Toshiharu

    1982-01-01

    A case of cerebral fat embolism is reported. A 18-year-old patient with multiple bone fractures was in semiconma immediately after an injury. Brain CT showed no brain swelling or intracranial hematoma. Hypoxemia and alcoholemia were noted on admission, which returned to normal without improvement of consciousness level. In addition, respiratory symptoms with positive radiographic changes, tachycardia, pyrexia, sudden drop in hemoglobin level, and sudden thrombocytopenia developed. These symptoms were compatible with Gurd's criteria of systemic fat embolism. Eight days after injury, multiple low density areas appeared on CT and disappeared within the subsequent two weeks, and subdural effusion with cerebral atrophy developed. These CT findings were not considered due to cerebral trauma. Diagnosis of cerebral fat embolism was made. The subdural effusion was drained. Neurologic and pulmonary recoveries took place slowly and one month following the injury the patient became alert and exhibited fully coordinated limb movement. The CT scans of the present case well corresponded with hitherto reported pathological findings. Petechiae in the white matter must have developed on the day of injury, which could not be detected by CT examination. It is suggested that some petechial regions fused to purpuras and then gradually resolved when they were detected as multiple low density areas on CT. CT in the purpuras phase would have shown these lesions as high density areas. These lesions must have healed with formation of tiny scars and blood pigment which were demonstrated as the disappearance of multiple low density areas by CT examination. Cerebral atrophy and subsequent subdural effusion developed as a result of demyelination. The patient took the typical clinical course of cerebral fat embolism and serial CT scans served for its assessment. (author)

  6. Terapia com células-tronco na síndrome do desconforto respiratório agudo Stem cell therapy in acute respiratory distress syndrome

    Directory of Open Access Journals (Sweden)

    Tatiana Maron-Gutierrez

    2009-03-01

    Full Text Available A síndrome do desconforto respiratório agudo é caracterizada por uma reação inflamatória difusa do parênquima pulmonar, podendo ser induzida por um insulto direto ao epitélio alveolar (síndrome do desconforto respiratório agudo pulmonar ou indireto através do endotélio vascular (síndrome do desconforto respiratório agudo extrapulmonar. Acredita-se que uma terapia eficaz para o tratamento da síndrome do desconforto respiratório agudo deva atenuar a resposta inflamatória e promover adequado reparo da lesão pulmonar. O presente artigo apresenta uma breve revisão acerca do potencial terapêutico das células-tronco na síndrome do desconforto respiratório agudo. Essa revisão bibliográfica baseou-se em uma pesquisa sistemática de artigos experimentais e clínicos sobre terapia celular na síndrome do desconforto respiratório agudo incluídos nas bases de dados MedLine e SciELO nos últimos 10 anos. O transplante de células-tronco promove melhora da lesão inflamatória pulmonar e do conseqüente processo fibrótico, induzindo adequado reparo tecidual. Dentre os mecanismos envolvidos, podemos citar: diferenciação em células do epitélio alveolar e redução na liberação de mediadores inflamatórios e sistêmicos e fatores de crescimento. A terapia com células-tronco derivadas da medula óssea pode vir a ser uma opção eficaz e segura no tratamento da síndrome do desconforto respiratório agudo por acelerar o processo de reparo e atenuar a resposta inflamatória. Entretanto, os mecanismos relacionados à atividade antiinflamatória e antifibrogênica de tais células necessitam ser mais bem elucidados, limitando, assim, o seu uso clínico imediato.Acute respiratory distress syndrome is characterized by an acute pulmonary inflammatory process induced by the presence of a direct (pulmonary insult that affects lung parenchyma, or an indirect (extrapulmonary insult that results from an acute systemic inflammatory response

  7. Gammagraphy of cerebral perfusion

    International Nuclear Information System (INIS)

    Vazquez, Silvia

    2003-01-01

    Important aspects of the gammagraphy of cerebral perfusion and the diverse clinical applications in the neurological diseases are comment in this article. We focus in the usefulness of the photon emission cerebral tomography (SPECT) and its capacity to cross the hemato encephalic barrier through the use of radiopharmacons like 99 mTc-H M-PAO and 99mTc-EDC, thus managing to offer functional data on the captantes neurons of the radiopharmacon. The clinical applications of SPECT are studied; cerebrovascular disease, transient ischemic attacks, dementias, Alzheimer disease, as well as other neurological diseases are referred. (The author)

  8. Experimental Focal Cerebral Ischemia

    DEFF Research Database (Denmark)

    Christensen, Thomas

    2007-01-01

    Focal cerebral ischemia due to occlusion of a major cerebral artery is the cause of ischemic stroke which is a major reason of mortality, morbidity and disability in the populations of the developed countries. In the seven studies summarized in the thesis focal ischemia in rats induced by occlusion...... in the penumbra is recruited in the infarction process leading to a progressive growth of the infarct. The penumbra hence constitutes an important target for pharmacological treatment because of the existence of a therapeutic time window during which treatment with neuroprotective compounds may prevent...

  9. Avaliação da influência da idade no potencial evocado auditivo de tronco encefálico

    Directory of Open Access Journals (Sweden)

    Anias C. R.

    2004-01-01

    Full Text Available O potencial evocado auditivo de tronco encefálico (ABR é um método simples, objetivo e não invasivo de avaliação das vias auditivas do tronco encefálico, que pode ser realizado em qualquer idade e que detecta a atividade elétrica desde a orelha interna até o colículo inferior. O ABR é composto por 7 ondas (I - VII, sendo as ondas I, III e V os componentes mais importantes. O nível de sensação (NS é uma unidade de estímulo que se baseia no limiar psicoacústico do indivíduo e a esse limiar acrescenta-se uma determinada intensidade de estímulo em decibel (dB, com o objetivo de fornecer a mesma quantidade de energia acústica em caso de perdas auditivas assimétricas. OBJETIVO: Avaliar a influência da idade no ABR em homens, utilizando o NS como unidade de estímulo. FORMA DE ESTUDO: Observacional coorte com corte transversal. MATERIAL E MÉTODO: Quinze indivíduos do sexo masculino entre 20 e 30 anos e 15 do sexo masculino a partir de 60 anos passaram por um critério clínico de seleção a fim de afastar outros fatores que pudessem influenciar os resultados. Foram determinadas as latências absolutas das ondas I, III, e V e as latências interpicos (LIPs I-III, III-V e I-V nos 2 grupos e os dados obtidos foram analisados estatisticamente. RESULTADOS: As latências absolutas e interpicos do ABR foram semelhantes nos 2 grupos estudados. CONCLUSÃO: No grupo etário analisado e nas condições pré-estabelecidas neste estudo, a idade não representou um fator de influência nos achados do ABR.

  10. Bioimpressão e produção de mini-órgãos com células tronco

    Directory of Open Access Journals (Sweden)

    Naila A. Oliveira

    Full Text Available RESUMO: A bioimpressão é considerada uma fonte promissora no desenvolvimento celular, e na produção de mini-órgãos, válulas, cartilagens que futuramente poderão ser utilizados na terapia para transplantes em animais e humanos. Assim, essa técnica poderá ser utilizada como uma terapia eletiva, no tratamento de injúrias e principalmente no tratamento de doenças crônico-degenerativas. Em humanos essa terapia está sendo pesquisada a fim de auxiliar a medicina no tratamento e regeneração de tecidos impressos a partir de arcabouços de células desenvolvidas a partir de células-tronco, biomateriais e impressões em 3D. O uso dessa tecnologia é também um auxiliar nas pesquisas oncológicas com o intuito de projetar e avaliar a proliferação celular de tumores, bem como a ação de novos medicamentos quimioterápicos. No entanto, a maior limitação para o uso da terapia utilizando-se a impressora de células, órgãos e tecidos em 3D é a falta de protocolos unificados com metodologias reprodutíveis e detalhadas; com o objetivo de viabilizar a utilização da impressora e a impressão de células, órgãos e tecidos em 3D. Dessa forma, esta revisão busca reunir as publicações mais atuais na área, as quais destacam os avanços no uso de bioimpressão com células-tronco, a fim de descrever as principais técnicas e os potenciais de utilização como alternativa terapêutica na medicina humana e veterinária.

  11. Avanços no uso de células-tronco em ortopedia Advances in the use of stem cells in orthopedics

    Directory of Open Access Journals (Sweden)

    Alexandre Fogaça Cristante

    2011-01-01

    Full Text Available As células primordiais, ou células-tronco, são células indiferenciadas multipotentes com a capacidade de originar qualquer tipo de tecido no organismo. Podem ter origem no blastocisto, sendo classificadas como embriônicas, ou em tecidos desenvolvidos de fetos, recém-nascidos ou adultos, conhecidas como célulastronco somáticas. Como um dos principais locais de isolamento da célula primordial está a medula óssea, tendo duas linhagens: células progenitoras hematopoéticas e mesenquimais. Existem diversos usos dessas células indiferenciadas na ortopedia, desde lesões cartilaginosas em patologias como osteoartrose, osteocondrite dissecante, condromalácia patelar, lesões ósseas como em pseudoartroses ou em perdas ósseas, ou em lesões nervosas como em trauma raquimedular. O estudo das células-tronco é provavelmente o campo de estudo mais promissor de toda a medicina que, em um espaço curto de tempo, irá revolucionar todas as especialidades médicas, tanto clínicas quanto cirúrgicas, solucionando patologias hoje de difícil abordagem.Primordial cells or stem cells are multipotent undifferentiated cells with the capacity to originate any type of cell in the organism. They may have their origins in the blastocyst and thus are classified as embryonic, or tissues developed in fetuses, newborns or adults and thus are known as somatic stem cells. Bone marrow is one of the main locations for isolating primordial cells, and there are two lineages: hematopoietic and mesenchymal progenitor cells. There are several uses for these undifferentiated cells in orthopedics, going from cartilaginous lesions in osteoarthrosis, osteochondritis dissecans and patellar chondromalacia, to bone lesions like in pseudarthrosis or bone losses, or nerve lesions like in spinal cord trauma. Studying stem cells is probably the most promising field of study of all within medicine, and this is shortly going to revolutionize all medical specialties (both clinical

  12. FORMA DE TRONCO E SORTIMENTOS DE MADEIRA DE Eucalyptus grandis Hill ex Maiden, NA REGIÃO SUDESTE DO ESTADO DO RIO GRANDE DO SUL

    Directory of Open Access Journals (Sweden)

    Paulo Renato Schneider

    2005-07-01

    Full Text Available No presente trabalho, foi estudada a forma de tronco do Eucalyptus grandis Hill ex Maiden, com base em 261 árvores cubadas, cobrindo diâmetros entre 8,0 cm e 74,0 cm ao nível do dap (diâmetro à altura do peito originadas de florestas de propriedade da Aracruz Celulose S. A., localizadas em hortos florestais da Depressão Central e do Escudo Sul-Riograndense, no Rio Grande do Sul, para a determinação de volume e formação de sortimentos de madeira em duas classes: serraria, compreendendo toras com diâmetro na ponta fina superior a 25,0 cm com casca e com comprimentos de 5,60 metros, 4,20 metros e 2,80 metros, priorizando a formação de sortimentos com o maior comprimento; indústria, para troncos ou porções destes com diâmetros entre 8,0 cm e 25,0 cm com casca. O polinômio do quinto grau, tendo como variável dependente os diâmetros relativos (di/d e independente as alturas relativas (hi/h, foi selecionado para descrever a forma, com estratificação dos dados em três classes de diâmetro à altura do peito: diâmetro até 20,0 cm; entre 20,0 cm e 30,0 cm e maiores que 30,0 cm, com coeficientes de determinação superiores a 0,97 e erro padrão da estimativa inferior a 6,2 %, permitindo estimar o volume absoluto e relativo dos sortimentos por integração da função de forma. O ajuste do modelo para o conjunto de árvores cobrindo toda a amplitude de diâmetros gerou um coeficiente de determinação igual à 0,98 e erro padrão da estimativa igual a 6,54 % permitindo também selecionar o modelo para ajuste da forma e obtenção dos sortimentos.

  13. Cerebral atrophic and degenerative changes following various cerebral diseases, (1)

    International Nuclear Information System (INIS)

    Kino, Masao; Anno, Izumi; Yano, Yuhiko; Anno, Yasuro.

    1980-01-01

    Patients having cerebral atrophic and degenerative changes following hypoglycemia, cerebral contusion, or cerebral hypoxia including cerebrovascular disorders were reported. Description was made as to cerebral changes visualized on CT images and clinical courses of a patient who revived 10 minutes after heart stoppage during neurosurgery, a newborn with asphyxia, a patient with hypoglycemia, a patient who suffered from asphyxia by an accident 10 years before, a patient with carbon monoxide poisoning at an acute stage, a patient who had carbon monoxide poisoning 10 years before, a patient with diffuse cerebral ischemic changes, a patient with cerebral edema around metastatic tumor, a patient with respiration brain, a patient with neurological sequelae after cerebral contusion, a patient who had an operation to excise right parietal lobe artery malformation, and a patient who was shooted by a machine gun and had a lead in the brain for 34 years. (Tsunoda, M.)

  14. Cerebral malaria: susceptibility weighted MRI

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    Vinit Baliyan

    2015-03-01

    Full Text Available Cerebral malaria is one of the fatal complications of Plasmodium falciparum infection. Pathogenesis involves cerebral microangiopathy related to microvascular plugging by infected red blood cells. Conventional imaging with MRI and CT do not reveal anything specific in case of cerebral malaria. Susceptibility weighted imaging, a recent advance in the MRI, is very sensitive to microbleeds related to microangiopathy. Histopathological studies in cerebral malaria have revealed microbleeds in brain parenchyma secondary to microangiopathy. Susceptibility weighted imaging, being exquisitely sensitive to microbleeds may provide additional information and improve the diagnostic accuracy of MRI in cerebral malaria.

  15. High Altitude Cerebral Edema

    Science.gov (United States)

    1986-03-01

    described neuropathological findings of cerebral edema and wi4espread petechial hemorrhages in two HAPE fatalities and later reported (52...lethargy, thirst, indigestion, hysterical outburst o: other behavior disturbances, decreased concentration, fever , couhh and peripheral edema (52...autopsy results from the two fatalities in their series. In both cases multiple, widespread petechial hemorrhages were noted throughout the brain. One

  16. Hyperventilation, cerebral perfusion, and syncope

    DEFF Research Database (Denmark)

    Immink, R V; Pott, F C; Secher, N H

    2014-01-01

    dioxide (PaCO2) and oxygen (PaO2) partial pressures so that hypercapnia/hypoxia increases and hypocapnia/hyperoxia reduces global cerebral blood flow. Cerebral hypoperfusion and TLOC have been associated with hypocapnia related to HV. Notwithstanding pronounced cerebrovascular effects of PaCO2...... the contribution of a low PaCO2 to the early postural reduction in middle cerebral artery blood velocity is transient. HV together with postural stress does not reduce cerebral perfusion to such an extent that TLOC develops. However when HV is combined with cardiovascular stressors like cold immersion or reduced...... cardiac output brain perfusion becomes jeopardized. Whether, in patients with cardiovascular disease and/or defect, cerebral blood flow cerebral control HV-induced hypocapnia elicits cerebral hypoperfusion, leading to TLOC, remains to be established....

  17. Recurrent cerebral thrombosis

    International Nuclear Information System (INIS)

    Iwamoto, Toshihiko; Abe, Shin-e; Kubo, Hideki; Hanyu, Haruo; Takasaki, Masaru

    1992-01-01

    Neuroradiological techniques were used to elucidate pathophysiology of recurrent cerebral thrombosis. Twenty-two patients with cerebral thrombosis who suffered a second attack under stable conditions more than 22 days after the initial stroke were studied. Hypertension, diabetes mellitus, and hypercholesterolemia were also seen in 20, 8, and 12 patients, respectively. The patients were divided into three groups according to their symptoms: (I) symptoms differed between the first and second strokes (n=12); (II) initial symptoms were suddenly deteriorated (n=6); and (III) symptoms occurring in groups I and II were seen (n=4). In group I, contralateral hemiparesis or suprabulbar palsy was often associated with the initial hemiparesis. The time of recurrent stroke varied from 4 months to 9 years. CT and MRI showed not only lacunae in both hemispheres, but also deep white-matter ischemia of the centrum semi-ovale. In group II, hemiparesis or visual field defect was deteriorated early after the initial stroke. In addition, neuroimaging revealed that infarction in the posterior cerebral artery was progressed on the contralateral side, or that white matter lesion in the middle artery was enlarged in spite of small lesion in the left cerebral hemisphere. All patients in group III had deterioration of right hemiparesis associated with aphasia. CT, MRI, SPECT, and angiography indicated deep white-matter ischemia caused by main trunk lesions in the left hemisphere. Group III seemed to be equivalent to group II, except for laterality of the lesion. Neuroradiological assessment of the initial stroke may help to predict the mode of recurrence, although pathophysiology of cerebral thrombosis is complicated and varies from patient to patient. (N.K.)

  18. Luto de profissionais em uma unidade de transplante de células-tronco hematopoéticas = Mourning of professionals in a hematopoietic stem cell transplantation unit

    Directory of Open Access Journals (Sweden)

    Rodrigues, Renata Pereira

    2012-01-01

    Full Text Available Introdução: O transplante de células-tronco hematopoéticas (TCTH é um procedimento que pode tanto recuperar a vida do paciente quanto conduzi-lo ao óbito. Não conseguir evitar a morte pode trazer ao profissional à vivência do luto e de seus limites. Objetivo: Compreender o processo de luto vivenciado pelos profissionais da saúde de uma Unidade TCTH. Materiais e Métodos: Trata-se de um estudo clínico-qualitativo de 8 profissionais de uma unidade de TCTH. Foram realizadas entrevistas semidirigidas e o material foi submetido à análise qualitativa de conteúdo. Resultados: Os resultados indicam que os profissionais de uma unidade de TCTH vivenciam o luto quando verificam processos lentos de morte e quando o sofrimento do paciente se torna muito intenso. Conclusão: O processo do luto do profissional ainda não é reconhecido e existe pouca oportunidade de expressão pública para facilitar a vivência desse luto

  19. Capacidade das células-tronco em regenerar o epitélio da pele - doi: 10.5102/ucs.v5i1.350

    Directory of Open Access Journals (Sweden)

    Valquíria Alice Michalczechen-Lacerda

    2008-11-01

    Full Text Available A pele é o primeiro contato do corpo com o meio exterior sendo responsável pela primeira linha de defesa imunológica. Quando ocorrem lesões profundas ela perde sua função ficando exposta a agentes infecciosos e inicia um processo lento de regeneração que pode não ser completo devido à necessidade de vários fatores ativação. Essa dificuldade é encontrada por existir camadas diferentes (epiderme, derme e tecido subcutâneo cujas células e composição de matriz extracelular serem diferentes. As células-tronco do epitélio (queratinócitas, da medula óssea e as mesenquimais demonstram ser eficientes no processo de recuperação total da pele através de um enxerto de tapete cultivo de células do próprio. Entretanto o processo de sinalização para diferenciações celulares não é totalmente conhecido.

  20. Stem-cell treatment in disc degeneration: What is the evidence? Células madre en el tratamiento de degeneración de disco: ¿Cual es la evidencia? Células tronco no tratamento de doença degenerativa discal: Qual é a evidência?

    Directory of Open Access Journals (Sweden)

    Manuela Peletti-Figueiró

    2013-01-01

    inflamatorios de la IVD degenerado. Además, estudios experimentales demostraron que las MSC se mantuvieron viables cuando inyectadas en el IVD y que eran capaces de regenerarse parcialmente del IVD degenerado y su estructura. Los pocos estudios clínicos presentes en la literatura presentan resultados divergentes. El uso de MSC se está estudiando ampliamente y muestra resultados prometedores en el tratamiento de la DDD. Aunque se hayan logrado muchos avances en estudios in vitro y experimentales, aún faltan estudios clínicos para comprobar el papel de las MSC en el manejo de la DDD.Revisar o potencial papel das células-tronco para o tratamento de doença degenerativa do disco intervertebral (IVD. Foi realizada uma revisão dos trabalhos da base de dados Medline em relação a células-tronco e doença degenerativa discal (DDD. Para fins de discussão dos dados, os trabalhos foram divididos em: revisão, in vitro, experimentais e clínicos. Os tratamentos disponíveis atualmente focam basicamente na redução dos sintomas, e não na reversão do processo degenerativo do DIV. O uso de células-tronco mesenquimais (CTM vem sendo proposto como uma opção de tratamento para DDD. Estudos in vitro demonstraram que as CTM são capazes de se diferenciarem em células do NP e que as CTM também diminuem os níveis inflamatórios do DIV degenerado. Além disso, estudos experimentais demonstraram que as CTM permaneciam viáveis quando injetadas no DIV e que eram capazes de regenerar parcialmente do DIV degenerado e sua estrutura. Os poucos estudos clínicos presentes na literatura apresentam resultados divergentes. O uso de CTM esta sendo amplamente estudado e mostra resultados promissores para o tratamento da DDD. Embora muitos avanços venham sendo alcançados em estudos in vitro e experimentais, ainda faltam estudos clínicos para comprovar o papel das CTM no manejo da DDD.

  1. Influência da fisioterapia aquática no controle de tronco na síndrome de pusher: estudo de caso Influence of hydrotherapy on trunk control in the pusher syndrome: case report

    Directory of Open Access Journals (Sweden)

    Cristiane Helita Zorél Meneghetti

    2009-09-01

    Full Text Available A síndrome de pusher, ou do não-alinhamento, é uma alteração do controle postural observada em pacientes com lesões encefálicas, que apresentam uma inclinação do tronco contralateral à lesão. O estudo visou analisar a influência da fisioterapia aquática no controle de tronco em um paciente de 78 anos com síndrome de pusher. Para o diagnóstico da síndrome foi utilizada a escala de avaliação do sintoma de empurrar (SCP, Scale for contraversive pushing. A simetria do tronco foi avaliada por fotogrametria, medindo-se, nas fotografias do paciente tiradas antes e depois do tratamento, os ângulos de alinhamento da cabeça, dos ombros e do tronco. A fisioterapia aquática consistiu em duas sessôes semanais de uma hora durante dois meses, totalizando 16 sessões, empregando os métodos Bad Ragaz e Halliwick, para fortalecimento da musculatura do tronco e dos membros superiores, respectivamente. Na avaliação após a intervenção, foi observada importante redução dos ângulos de inclinação da cabeça (de 31,7º para 10,6º, dos ombros (de 10,3º para 1,7º e do tronco (de 9,6º para 3,0º. O programa de fisioterapia aquática, portanto, propiciou ao participante com a síndrome de pusher sensível melhora na simetria e alinhamento do tronco.Pusher, or lateropulsion, syndrome is a clinical disorder following brain damage in which patients actively push away from the nonhemiparetic side, leading to a loss of postural balance. This study analysed the effect of hydrotherapy on trunk alignment in a 78 year-old male patient with the syndrome. Pusher syndrome was diagnosed by means of the scale for contraversive pushing. Trunk symmetry was assessed by photogrammetry: head, shoulder and trunk alignment angles were measured on photographs taken before and after treatment. Aquatic therapy consisted in two weekly one-hour sessions for two months (total 16 sessions, using the Bad Ragaz and the Halliwick techniques, with the purpose of

  2. Análisis del síndrome del cuidador primario en madres de niños y niñas de 0 a 2 años con parálisis cerebral de la Fundación Jonathan.

    OpenAIRE

    Toledo Enríquez, Karla Tamara

    2012-01-01

    This study focuses primary caregiver syndrome in mothers of children aged 0-2 years with cerebral palsy are interested in knowing the impact the diagnosis has on mothers and determine the discomforts associated with the role of caring for these children / as . We investigate five mothers caregivers, investigating sociodemographic information, the level of stress and strain, overload, and the health status and relevant information that allowed the hypothesis to answer. Este estudio se centr...

  3. Bases estructurales de la memoria declarativa. Estudio de la interacción entre la formación del hipocampo y la corteza cerebral en el primate Macaca fascicularis.

    OpenAIRE

    Legidos García, María Ester

    2014-01-01

    La memoria otorga al ser humano una biografía y un conjunto de hechos que le proporciona una identidad, le orienta en el mundo y en su entorno cultural (memoria declarativa). Evidencias clínicas y experimentales muestran que los centros nerviosos cuyo epicentro es el lóbulo temporal medial, son imprescindibles para la consolidación y evocación de los recuerdos. Entre estos centros nerviosos destaca la Formación del Hipocampo (FH) compuesta de giro dentado, campos amónicos CA3, CA2, CA1, subíc...

  4. Disección traumática de la arteria carótida interna y embolismo cerebral en un jugador de fútbol: Reporte del primer caso

    Directory of Open Access Journals (Sweden)

    Luisa S. Talledo Paredes

    2012-03-01

    Full Text Available Reportamos el caso de un varón de 18 años quien sufrió contusión cervical por impacto con balón de fútbol. Tres días después fue hospitalizado con hemiplejia derecha directa y afasia de expresión. La resonancia magnética cerebral mostró lesión isquémica izquierda en ganglios basales. El doppler carotideo evidenció trombo desde el origen de la arteria carótida común izquierda extendida a la arteria carótida interna izquierda (CII y la angiotomografía documentó disección de CII (lesión traumática carotídea tipo IV. Se optó por anticoagulación con warfarina y fisioterapia de rehabilitación; con evolución favorable. La incidencia de la injuria traumática carotídea es muy rara, más aún en futbolistas; el tratamiento es aún controversial, por lo que consideramos de interés el reporte de este caso.

  5. Cerebral localization in antiquity.

    Science.gov (United States)

    Rose, F Clifford

    2009-07-01

    Fragments of neurology can be found in the oldest medical writings in antiquity. Recognizable cerebral localization is seen in Egyptian medical papyri. Most notably, the Edwin Smith papyrus describes hemiplegia after a head injury. Similar echoes can be seen in Homer, the Bible, and the pre-Hippocratic writer Alcmaeon of Croton. While Biblical writers thought that the heart was the seat of the soul, Hippocratic writers located it in the head. Alexandrian anatomists described the nerves, and Galen developed the ventricular theory of cognition whereby mental functions are classified and localized in one of the cerebral ventricles. Medieval scholars, including the early Church Fathers, modified Galenic ventricular theory so as to make it a dynamic model of cognition. Physicians in antiquity subdivided the brain into separate areas and attributed to them different functions, a phenomenon that connects them with modern neurologists.

  6. Cerebral venous thrombosis

    International Nuclear Information System (INIS)

    Soralova, T.; Sevcikova, H.; Petersky, D.

    2014-01-01

    We decided to process this theme due to its nonspecific clinical features as they often cause diagnostic problems not only to clinicians but also to diagnostic. It is important to think of this disease mainly in young women who administer hormonal contraception. Imaging methods play the crucial role in diagnostic of cerebral venous sinus thrombosis. The gold standard is a native CT of brain which shows the venous sinus thrombosis as a hyperdense lesion in the locus of the sinus (dense triangle sign), CT venography shows the sinus thrombosis as a defect in a contrast filling of the venous sinus (empty delta sign). Other investigative methods are magnetic resonance imaging or MRA. In short we also mention quite a rare but more serious thrombosis of profound cerebral veins v. cerebri magna-Galeni, vv. cerebri internae). The importance of early diagnostic and non specificity of symptoms is presented in 3 clinical cases that are the part of this work. (author)

  7. Applications of cerebral SPECT

    Energy Technology Data Exchange (ETDEWEB)

    McArthur, C., E-mail: claire.mcarthur@nhs.net [Department of Neuroradiology, Institute of Neurological Sciences, Glasgow (United Kingdom); Jampana, R.; Patterson, J.; Hadley, D. [Department of Neuroradiology, Institute of Neurological Sciences, Glasgow (United Kingdom)

    2011-07-15

    Single-photon emission computed tomography (SPECT) can provide three-dimensional functional images of the brain following the injection of one of a series of radiopharmaceuticals that crosses the blood-brain barrier and distributes according to cerebral perfusion, neurotransmitter, or cell density. Applications include differentiating between the dementias, evaluating cerebrovascular disease, preoperative localization of epileptogenic foci, diagnosing movement disorders, and evaluation of intracerebral tumours, while also proving a useful research tool. Unlike positronemission tomography (PET), SPECT imaging is widely available and can be performed in any department that has access to a rotating gamma camera. The purpose of this review is to demonstrate the utility of cerebral SPECT and increase awareness of its role in the investigation of neurological and psychiatric disorders.

  8. Cerebral ketone body metabolism.

    Science.gov (United States)

    Morris, A A M

    2005-01-01

    Ketone bodies (KBs) are an important source of energy for the brain. During the neonatal period, they are also precursors for the synthesis of lipids (especially cholesterol) and amino acids. The rate of cerebral KB metabolism depends primarily on the concentration in blood; high concentrations occur during fasting and on a high-fat diet. Cerebral KB metabolism is also regulated by the permeability of the blood-brain barrier (BBB), which depends on the abundance of monocarboxylic acid transporters (MCT1). The BBB's permeability to KBs increases with fasting in humans. In rats, permeability increases during the suckling period, but human neonates have not been studied. Monocarboxylic acid transporters are also present in the plasma membranes of neurons and glia but their role in regulating KB metabolism is uncertain. Finally, the rate of cerebral KB metabolism depends on the activities of the relevant enzymes in brain. The activities vary with age in rats, but reliable results are not available for humans. Cerebral KB metabolism in humans differs from that in the rat in several respects. During fasting, for example, KBs supply more of the brain's energy in humans than in the rat. Conversely, KBs are probably used more extensively in the brain of suckling rats than in human neonates. These differences complicate the interpretation of rodent studies. Most patients with inborn errors of ketogenesis develop normally, suggesting that the only essential role for KBs is as an alternative fuel during illness or prolonged fasting. On the other hand, in HMG-CoA lyase deficiency, imaging generally shows asymptomatic white-matter abnormalities. The ability of KBs to act as an alternative fuel explains the effectiveness of the ketogenic diet in GLUT1 deficiency, but its effectiveness in epilepsy remains unexplained.

  9. Radiopharmaceuticals for cerebral studies

    International Nuclear Information System (INIS)

    Leon Cabana, Alba

    1994-01-01

    For obtain good brain scintillation images in nuclear medicine must be used several radiopharmaceuticals. Cerebral studies give a tumors visual image as well as brain anomalities detection and are helpful in the diagnostic diseases . Are described in this work: a cerebrum radiopharmaceuticals classification,labelled compounds proceeding and Tc 99m good properties in for your fast caption, post administration and blood purification for renal way

  10. Neonatal cerebral infarction

    International Nuclear Information System (INIS)

    Fujimoto, Shinji; Togari, Hajime; Sobajima, Hisanori; Suzuki, Shigesumi; Wada, Yoshiro; Yokochi, Kenji; Nishimura, Yutaka; Inukai, Kazuhisa; Futamura, Masahide.

    1992-01-01

    In a retrospective multi-center study, we investigated eighteen infants with unilateral cerebral infarctions confirmed by computed tomography (CT) scans. The initial symptoms were observed in all the patients between 0 and 3 days of age. Convulsions or apneic attacks were the initial symptoms in all but one. Only 4 patients had complicated obstetric histories and none showed polycythemia or electrolyte abnormalities. All of the initial CT scans revealed unilaterally localized hypodense areas. In 10, the initial CT scans were performed within 24 hours after the clinical onset. In 16, the lesions were within the territory of the middle cerebral artery, 9 of which also involved the cortico-spinal tract (CST). In the remaining 2 patients, the lesions were located whithin the territory of the posterior cerebral artery. None of the 9 patients without CST involvement developed hemiplegia, whereas 5 (56%) of the 9 with CST involvement had hemiplegia, which is a fairly low incidence compared with that in adult cases. This difference was thought to be related to neonatal brain plasticity. (author)

  11. Centro Nacional de Salud Ocupacional y Protección del Ambiente para la Salud (CENSOPAS)

    OpenAIRE

    Instituto Nacional de Salud

    2005-01-01

    En el mes de agosto del 2005, se atendieron en el servicio de salud de psicología del Centro nacional de Salud Ocupacional del INS, 45 personas de las cuales sólo una persona presentó alguna alteración de su salud mental (Síndrome Orgánico Cerebral)

  12. Cerebral Oximetry in Cardiac Surgery

    Directory of Open Access Journals (Sweden)

    A. N. Shepelyuk

    2012-01-01

    Full Text Available Based on the data of numerous current references, the review describes different neuromonitoring methods during cardiac surgery under extracorporeal circulation. It shows that it is important and necessary to make neuromonitoring for the early diagnosis and prevention of neurological complications after cardiac surgery. Particular attention is given to cerebral oximetry; the possibilities and advantages of this technique are described. Correction of cerebral oximetric values is shown to improve survival rates and to reduce the incidence of postoperative complications. Lack of cerebral oximetry monitoring denudes a clinician of important information and possibilities to optimize patient status and to prevent potentially menacing complications, which allows one to conclude that it is necessary to use cerebral oximetry procedures within neu-romonitoring in cardiac surgery. Key words: extracorporeal circulation, cerebral oximetry, neurological dysfunction, cerebral oxygenation.

  13. Histología y morfometría de piel del pez Eremophilus mutisii (Trychomecteridae, Siluriformes

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    Rocío Johanna Bonilla Lizarazo

    2008-06-01

    Full Text Available Se estudió la piel del pez dulceacuícola endémico de Colombia Eremophylus mutissi. Se tomaron muestras de piel (0.5x0.5 cm² de 11 especimenes en seis partes del cuerpo (mandíbulas, cabeza dorsal, tronco dorsal, tronco caudal, tronco medial y abdominal. Se fijaron en formaldehído al 4%, con deshidratación en etanol al 95 % e isopropanol al 99%, inclusión en parafina y cortes a 5 µm. La piel está constituida por dos capas cutáneas (epidermis y dermis y una capa subcutánea (hipodermis: la epidermis tiene tres capas con células secretoras, células epiteliales y pocas células gustativas; la dermis está separada de la epidermis por una membrana basal. Observamos fibroblastos, dos capas de melanóforos y algunos vasos sanguíneos; la hipodermis tiene un tejido adiposo vascularizado. La dermis es más delgada que la epidermis; la piel tiene más células tipo clava que células mucosas. El tronco medio tiene muchas células clava y células mucosas. La piel de E. mutissi parece tener una función principalmente protectora.Skin histology and morphometry of the fish Eremophilus mutisii (Trychomecteridae, Siluriformes. The tropical freshwater fish Eremophylus mutisii is endemic to the Cundinamarca highland in Colombia. Skin samples (0.5x0.5 cm² were taken from 11 specimens at six body parts (mandible, dorsal head, dorsal trunk, caudal trunk, medial trunk and abdominal area, fixed in 4% formaldehyde, dehydrated in 95% ethanol and 99% isopropanol, embedded in paraffin and sectioned at 5 µm. The skin is made of two mayor cutaneous layers (epidermis and dermis and a subcutaneous layer (hypodermis. The epidermis presents three layers with secretory cells, epithelial cells and a few taste buds; the dermis is separated from the epidermis by a basal membrane. We observed fibroblasts, two layers of melanophors and some blood vessels; the hypodermis has vascularized adipose tissue. Skin thickness changes with body area; the dermis is thicker than

  14. Cerebral malformations without antenatal diagnosis

    Energy Technology Data Exchange (ETDEWEB)

    Girard, Nadine J. [Diagnostic Neuroradiology, Hopital Timone, Marseille (France)

    2010-06-15

    Cerebral malformations are usually described following the different steps in development. Disorders of neurulation (dysraphisms), or diverticulation (holoprosencephalies and posterior fossa cysts), and total commissural agenesis are usually diagnosed in utero. In contrast, disorders of histogenesis (proliferation-differentiation, migration, organization) are usually discovered in infants and children. The principal clinical symptoms that may be a clue to cerebral malformation include congenital hemiparesis, epilepsy and mental or psychomotor retardation. MRI is the imaging method of choice to assess cerebral malformations. (orig.)

  15. The influence of the day of the week of hospital admission on the prognosis of stroke patients Influencia del día de la semana de admisión hospitalaria en el pronóstico de pacientes con accidente vascular cerebral O dia da semana de admissão hospitalar influenciando o prognóstico de pacientes com acidente vascular cerebral

    Directory of Open Access Journals (Sweden)

    Paulo A. Lotufo

    2013-04-01

    Full Text Available This study aimed to evaluate the weekday and weekend distribution of stroke case hospital admissions and their respective prognosis based on a sample from the Estudo de Mortalidade e Morbidade do Acidente Vascular Cerebral (EMMA, a cohort of stroke patients admitted to a community hospital in the city of São Paulo, Brazil. We ascertained all consecutive cases of first-time strokes between April 2006 and December 2008 and performed a subsequent one-year follow-up. No association was found between frequency of hospital admissions due to ischemic and hemorrhagic strokes and the specific day of the week on which the admission occurred. However, ten-day and twelve-month case-fatality was higher in hemorrhagic stroke patients admitted at the weekend. We also found that intracerebral hemorrhage patients admitted on weekends had a worse survival rate (50% compared with those admitted during weekdays (25.6%, P log-rank = 0.03. We found a multivariate hazard ratio of 2.49 (95%CI: 1.10-5.81, P trend = 0.03 for risk of death at the weekend compared to weekdays for intracerebral hemorrhage cases. No difference in survival was observed with respect to the overall sample of stroke or ischemic stroke patients.El estudio evaluó la distribución de casos incidentes de accidente vascular cerebral (AVC que fueron al hospital de lunes a viernes o durante los fines de semana en el Estudio de Mortalidad y Morbilidad del AVC (EMMA. El EMMA es una cohorte de pacientes con AVC en un hospital comunitario de la ciudad de São Paulo, Brasil. Casos consecutivos de primer episodio de AVC internados, entre abril de 2006 y diciembre de 2008, fueron seguidos prospectivamente durante un año. No hubo diferencia en la frecuencia de las internaciones por AVC isquémico o hemorrágico durante los días de la semana. Sin embargo, la letalidad en 10 días y tras un año había aumentado en el AVC hemorrágico. En el análisis de supervivencia de un año, pacientes admitidos los

  16. Fuerza muscular, flexibilidad y postura en la prevalencia de dolor lumbar de los tripulantes de helicópteros del Ejército Nacional de Colombia

    Directory of Open Access Journals (Sweden)

    Imma Caicedo Molina

    2013-10-01

    Full Text Available Objetivo. Determinar la relación entre la fuerza muscular, la flexibilidad y la postura con la prevalencia de dolor lumbar en los tripulantes de helicópteros del Ejército Nacional de Colombia. Materiales y métodos. Se realizó un estudio de tipo transversal bajo un modelo de regresión logística múltiple, enfocado en la medición de la fuerza muscular, la flexibilidad y la postura en tripulantes de helicópteros del Ejército Nacional de Colombia. Resultados. 108 tripulantes fueron evaluados, de quienes el 59,3 % presentó dolor lumbar. Se encontró que la fuerza de los músculos extensores de tronco constituyó un factor de protección (OR= 0,98. p0,05 y OR=1,04, p<0,05, Chi cuadrado 2,80 respectivamente. Conclusión. La fuerza muscular adecuada de los extensores de tronco constituye un factor protector frente al dolor lumbar en los tripulantes de helicópteros. Sin embargo, es necesario desarrollar más investigaciones en esta población que permitan mayor comprensión de los factores relacionados con el dolor. Las variables intervinientes de contexto, junto con las variables fisiocinéticas, constituyen una red compleja de determinantes del dolor lumbar en los tripulantes de helicópteros.

  17. Molecular pathophysiology of cerebral edema

    Science.gov (United States)

    Gerzanich, Volodymyr; Simard, J Marc

    2015-01-01

    Advancements in molecular biology have led to a greater understanding of the individual proteins responsible for generating cerebral edema. In large part, the study of cerebral edema is the study of maladaptive ion transport. Following acute CNS injury, cells of the neurovascular unit, particularly brain endothelial cells and astrocytes, undergo a program of pre- and post-transcriptional changes in the activity of ion channels and transporters. These changes can result in maladaptive ion transport and the generation of abnormal osmotic forces that, ultimately, manifest as cerebral edema. This review discusses past models and current knowledge regarding the molecular and cellular pathophysiology of cerebral edema. PMID:26661240

  18. Peces del Noroeste del Ecuador

    OpenAIRE

    Barriga, Ramiro

    1994-01-01

    La ictiofauna del occidente del Ecuador es poco conocida. Los peces del noroccidente son diferentes a los del suroccidente del Ecuador. 34 familias y 82 especies fueron colectadas que equivale al 11 % de las especies de peces continentales registradas en el Ecuador. Icteogeográficamente se sabe que la costa ecuatoriana posee dos provincias: la del Pacifico Norte y la del Guayas, se determinó que el límite de las dos provincias es el río Santiago ya que las especies del mencionado río so...

  19. Potenciais evocados auditivos de tronco encefálico de ex-usuários de drogas Brain stem evoked response audiometry of former drug users

    Directory of Open Access Journals (Sweden)

    Tainara Milbradt Weich

    2012-10-01

    Full Text Available As drogas ilícitas são conhecidas pelos seus efeitos deletérios no sistema nervoso central; no entanto, elas também podem atingir o sistema auditivo, provocando alterações. OBJETIVOS: Analisar e comparar os resultados dos potenciais evocados auditivos de tronco encefálico (PEATE de frequentadores de grupos de apoio a ex-usuários de drogas. MÉTODO: Estudo transversal, não experimental, descritivo e quantitativo. A amostra foi composta por 17 indivíduos divididos conforme o tipo de droga mais consumida: 10 indivíduos no grupo maconha (G1 e sete no grupo crack/cocaína (G2. Eles foram subdivididos pelo tempo de uso de drogas: um a cinco anos, seis a 10 anos e mais que 15 anos. A avaliação foi feita por meio de anamnese, audiometria tonal liminar, medidas de imitância acústica e PEATE. RESULTADOS: Ao comparar os resultados de G1 e G2, independente do tempo de uso de drogas, não se observou diferença estatisticamente significante nas latências absolutas e nos intervalos interpicos. No entanto, apenas cinco dos 17 indivíduos tiveram PEATE com resultados adequados para a faixa etária. CONCLUSÃO: Independentemente do tempo de utilização das drogas, o uso de maconha e crack/cocaína pode provocar alterações difusas no tronco encefálico, comprometendo a transmissão do estímulo auditivo.Illicit drugs are known for their deleterious effects upon the central nervous system and more specifically for how they adversely affect hearing. OBJECTIVE: This study aims to analyze and compare the hearing complaints and the results of brainstem evoked response audiometry (BERA of former drug user support group goers. METHODS: This is a cross-sectional non-experimental descriptive quantitative study. The sample consisted of 17 subjects divided by their preferred drug of use. Ten individuals were placed in the marijuana group (G1 and seven in the crack/cocaine group (G2. The subjects were further divided based on how long they had been using

  20. Registro de la actividad eléctrica cerebral de la atención implicada en la conducción bajo el efecto del alcohol usando un instrumento BCI (brain control interface

    Directory of Open Access Journals (Sweden)

    Sandra Camelo

    2015-01-01

    Full Text Available La ingestión de alcohol se ha vinculado con cambios característicos en la actividad eeg , y estos cambios dependen de diversos factores; si bien se reconoce en la literatura una amplia variabilidad de diseños experimentales, la gran mayoría de estos se han centrado en reportar el efecto del alcohol en su - jetos alcohólicos con antecedentes de consumo de dosis casi siempre altas y frecuentes, y en un me - nor porcentaje, el efecto del alcohol cuando hay un consumo agudo de dosis bajas de alcohol. El pre - sente proyecto registró la actividad eléctrica cere - bral de la atención implicada en la conducción con el equipo bci ( brain control interface epoc , bajo el efecto de 0,300 g de alcohol, correspondiente a un porcentaje de 0,02 % bac ( blood alcohol content en prueba de alcoholímetro, y a su vez en ausencia de alcohol mediante un diseño pre-experimental con preprueba-postprueba, con un solo grupo de 30 es - tudiantes universitarios entre 18 y 45 años de edad. Los resultados mostraron que el alcohol en dosis bajas logra generar cambios en la dinámica de las ondas, disminuyendo la amplitud de ondas rápidas como alfa (9-13Hz y beta (14-30 Hz, específicamente en zonas asociadas a los lóbulos frontales implicadas en tareas de atención sostenida en conducción.

  1. Religiosidade no contexto das terapias com células-tronco: uma investigação comparativa entre pesquisadores "iniciantes e iniciados" e seus pacientes

    Directory of Open Access Journals (Sweden)

    Naara Luna

    2008-01-01

    Full Text Available Terapias experimentais com células-tronco têm despertado interesse público devido à expectativa de cura milagrosa. O artigo analisa as representações e a adesão religiosa de pessoas envolvidas em diferentes protocolos experimentais de terapia celular: pacientes e suas famílias e também pesquisadores de vários níveis. O trabalho de campo ocorreu em instituição de ensino superior. Pretende-se comparar posições de pacientes e de pesquisadores, e entre os pesquisadores conforme seu nível de formação com respeito a: adesão religiosa atual e formação anterior e sua posição sobre uso de embriões humanos em pesquisa. O uso de embriões é prática combatida pela Igreja Católica e debatida por diferentes confissões cristãs e não-cristãs. Outro objetivo é verificar representações de cura e milagre referentes ao poder das células.Experimental therapies with stem cells have waken public interest due to expectations of miraculous healings. The article analyses representations and religious commitment of people involved in different experimental protocols of cellular therapy: patients, their families and researchers of several levels. Fieldwork took place in a higher education institution. The objective is to compare the positions of patients and researchers and also inside the researchers group (according to researcher's educational level regarding: present religious commitment and previous background and their reactions about human embryo research. Catholic Church opposes the use of human embryos as research material and other religious confessions debate this subject. The paper also examines representations of cure and miracle related to stem cells.

  2. Mídia e conhecimento público: as notícias sobre as células-tronco Media and public knowledge: news on stem-cell studies

    Directory of Open Access Journals (Sweden)

    Claudio Bertolli Filho

    2007-09-01

    Full Text Available O objetivo deste texto é analisar o enfoque adotado pelo jornal Folha de S. Paulo no referente ao emprego das células-tronco nas pesquisas científicas, tomando-se para estudo os editoriais, artigos e cartas dos leitores publicados no transcorrer do ano de 2005. A análise dos textos produzidos pelo jornal deixa claro o posicionamento do órgão de imprensa em favor do amplo uso das células-tronco, mas a análise das cartas dos leitores demonstra que nem todos concordam com o que é proposto pelo jornal. Nesse processo, a mídia contribui para a constituição de um conhecimento público sobre os temas referentes à biologia celular e molecular, sem contudo tornar a opção do jornal como única e irrefutável. Palavras-chave: Mídia impressa. Conhecimento público. Produção de sentidos. Células-tronco. Folha de S. Paulo. This text seeks to analyze the Folha de São Paulo newspaper’s focus on the employment of stem-cells in scientific research, looking into editorials, articles and reader letters published throughout 2005. The analysis of the newspaper’s own texts leaves no doubt as for the editors’ support of broad stem-cell employment in research, but the letters from readers show that not everyone agrees with the newspaper’s version of the facts. In this process, media contributes in building general public knowledge on cell and molecular biology-related themes, without, however, establishing the newspaper’s opinion as the irrefutable truth. Keywords: Media. Newspaper. Public knowledge. Stem-cell. Folha de S. Paulo.

  3. Potenciais evocados auditivos de tronco encefálico em usuários de crack e múltiplas drogas Auditory brainstem evoked potentials in crack and multiple drugs addicts

    Directory of Open Access Journals (Sweden)

    Loretta Fabianni Nigri

    2009-01-01

    Full Text Available OBJETIVO: Analisar os potenciais evocados auditivos de tronco encefálico em usuários de crack e múltiplas drogas, bem como levantar as possíveis queixas auditivas e de equilíbrio nesta população. MÉTODOS: Foram avaliados 40 usuários de drogas (20 com uso há mais de cinco anos e 20 há menos de cinco anos e 20 não usuários, do sexo masculino, com idades entre 19 e 46 anos, com limiares auditivos dentro da normalidade. RESULTADOS: Não houve diferenças significativas dos potenciais evocados auditivos de tronco encefálico dos usuários de drogas quando comparados ao grupo controle. CONCLUSÃO: Os potenciais evocados auditivos de tronco encefálico dos usuários de drogas não diferiram significantemente do grupo controle. As queixas apresentadas pelos usuários de drogas foram hiperacusia, alucinação auditiva, zumbido e alteração de equilíbrio.PURPOSE: To study the findings of auditory brainstem evoked potentials in crack and multiple drugs users, as well as to raise possible auditory and balance complaints in this population. METHODS: A total of 40 drugs addicts (20 who had been using drugs for over five years and 20 for less than five years and 20 non-users were evaluated. Subjects were all male, with ages ranging from 19 to 46 years, and had auditory thresholds within normal. RESULTS: No significant statistical differences were found regarding the auditory brainstem evoked potentials findings of the addicts group, when compared to the non-users. CONCLUSION: Auditory brainstem evoked potentials in crack and multiple drugs users did not differ significantly from the control group. Complaints presented by drugs addicts were hyperacusis, auditory hallucination, tinnitus and altered balance.

  4. Correção de aneurisma do tronco braquiocefálico, 10 anos após traumatismo torácico fechado Correction of an innominate artery aneurysm, 10 years after a blunt chest trauma

    Directory of Open Access Journals (Sweden)

    José Almeida Lopes

    2012-03-01

    Full Text Available Aneurismas do tronco braquiocefálico são extremamente raros. Os autores apresentam o caso clínico de um doente de 22 anos de idade, com antecedente de atropelamento de alta energia há cerca de 10 anos por motociclo, com traumatismo toraco-abdominal anterior, em quem foi acidentalmente descoberto um aneurisma do tronco braquiocefálico com 52mm. Para a exclusão do referido aneurisma o doente foi submetido com sucesso à construção de um bypass aorta ascendente-carotídio-subclávio com prótese bifurcada de Dacron® (14x7mm, com abordagem por esternotomia mediana, cervical e supra-clavicular. É feita uma revisão da literatura, sendo descritas e discutidas as características clínicas, o tratamento cirúrgico e o mecanismo de traumatismo torácico sobre o tronco braquiocefálico.Innominate artery aneurysms are extremely rare. The authors present a case report of a 22-year-old patient, in whom was accidently discovered an innominate artery aneurysm of 52 mm, 10 years after a blunt thoraco-abdominal trauma caused by a high energy running over by a motorcycle. For the exclusion of the aneurysm, the patient was successfully submitted to the construction of an ascending aorta-carotid-subclavian bypass with bifurcated Dacron® graft (14x7mm, by means of a median sternotomy, right cervical and supra-clavicular approaches. Review of the literature, clinical features, surgical treatment and chest trauma mechanisms over the innominate artery are described and discussed.

  5. Cerebral Amyloid Angiopathy

    Directory of Open Access Journals (Sweden)

    Mahmut Edip Gürol

    2009-03-01

    Full Text Available Cerebral amyloid angiopathy (CAA is characterized by the accumulation of amyloid beta-peptides (Ab in the walls of leptomeningeal arteries, arterioles, and veins. Despite the fact that these pathological changes were first described in 1909, major advancement in our understanding of the clinicoradiological manifestations, neurobiology, and course of CAA has occurred only during the last 30 years. No significant associations have been shown between CAA and other systemic/visceral amyloidoses or vascular risk factors, including hypertension. CAA is well known as the most common cause of spontaneous and anticoagulant-related lobar parenchymal ICH in the elderly. It also causes lobar cerebral microbleeds (CMBs, small dot-like dark susceptibility artifacts visible with gradient recalled echo (GRE-magnetic resonance imaging (MRI. CMBs are important markers of disease severity and predictors of CAA progression. Amyloid angiopathy is also a common cause of ischemic microvascular white matter disease (WMD and deep cerebral infarctions. Such WMD is defined as subcortical and periventricular white matter changes without obvious infarction, as well as a dark appearance on computerized tomography (CT and a bright appearance on fluid attenuated inversion recovery (FLAIR-MRI. CAA-related vascular dysfunction, with its hemorrhagic and ischemic complications, is a recognized contributor to vascular cognitive impairment in the elderly, an independent effect that is synergistically increased by Alzheimer pathologies, such as plaques and tangles. A set of clinicoradiological criteria was established for the accurate diagnosis of CAA. According to the Boston Criteria, patients aged 55 years and older with multiple hemorrhages (on CT or GRE-MRI restricted to the lobar, cortical, or corticosubcortical regions (cerebellar hemorrhage allowed are diagnosed as probable CAA when no other etiology is found; a single hemorrhage in the same region is classified as possible

  6. Transplante de células-tronco hematopoéticas em doenças reumáticas. Parte 2: experiência brasileira e perspectivas futuras

    OpenAIRE

    Voltarelli, Júlio C.; Stracieri, Ana Beatriz P. L.; Oliveira, Maria Carolina B.; Godoi, Dannielle F.; Moraes, Daniela A.; Pieroni, Fabiano; Malmegrim, Kelen C. R.; Coutinho, Marina A.; Simões, Belinda P.; Massumoto, Celso; Hamerschlak, Nelson; Scheinberg, Morton; Ferreira, Eurípides; Coutinho, Mariana; Ostronoff, Maurício

    2005-01-01

    Nesta revisão, discutem-se os resultados dos transplantes de células-tronco hematopoéticas (TCTH) para doenças reumáticas graves e refratárias à terapia convencional realizados no Brasil. São analisados os resultados preliminares obtidos no Brasil com o TCTH autólogo em casos esporádicos (N=3) e no protocolo cooperativo iniciado em 2001 (N=18). Neste protocolo, dentre os 8 casos de nefrite lúpica, houve 3 remissões sustentadas, 3 óbitos, 1 falha de mobilização e 1 seguimento ainda muito curto...

  7. Avaliação da eficácia do uso de fatores de crescimento em orabase e laserterapia no tratamento da mucosite oral em pacientes submetidos ao transplante de células tronco hematopoiéticas.

    OpenAIRE

    Brasil, Catarina da Mota Vasconcelos

    2013-01-01

    A mucosite oral (MO) é uma inflamação aguda da mucosa decorrente do tratamento antineoplásico que pode resultar em dor, pode limitar a fala, a mastigação e aumenta os riscos de desenvolvimento de infecções por microorganismos oportunistas. O objetivo deste estudo pioneiro foi avaliar a eficácia do uso tópico de fatores de crescimento (EGF, IGF, TGFβ3, bFGF) veiculados em orabase, associados a laserterapia para tratamento da MO em pacientes submetidos ao transplante de células tronco hematopoi...

  8. Alterações eletromiográficas dos músculos do tronco de pacientes com hemiparesia após acidente vascular encefálico Electromyographic alterations of trunk muscle of patients with post-stroke hemiparesis

    Directory of Open Access Journals (Sweden)

    Fernando Cesar Iwamoto Marcucci

    2007-09-01

    Full Text Available O acidente vascular encefálico é a principal causa de incapacidade crônica em adultos, porém poucos estudos avaliaram a motricidade do tronco nestes indivíduos. OBJETIVO: Comparar a atividade mioelétrica do tronco entre indivíduos hemiparéticos e controle. MÉTODO: Foram avaliados oito indivíduos hemiparéticos e oito controles, por meio de eletromiografia de superfície (EMGs, durante atividades de flexão dos membros inferiores e rotação do tronco em supino; levantar e elevação dos membros superiores na posição sentada. RESULTADOS: O músculo reto abdominal parético apresentou maior ativação que o grupo controle (p=0,031 durante a flexão dos membros inferiores. Os músculos oblíquos apresentaram, bilateralmente, maior ativação na elevação dos membros inferiores do que na rotação (p=0,014 e p=0,002, respectivamente. Não houve diferenças entre músculos eretores durante as atividades. CONCLUSÃO: Os músculos flexores do tronco de indivíduos hemiparéticos apresentaram alterações motoras no reto abdominal do lado parético e realizam compensações por meio dos oblíquos externos.Stroke is the main cause of chronic disability in adults, but few studies evaluated the trunk motor activity in affected subjects. OBJECTIVE: To compare the myoelectrical activity of trunk muscle in hemiparetic and control subjects. METHOD: Eight hemiparetic and eight control subjects were assessed during lower extremities flexion and trunk rotation in supine position; stand up and rise up upper extremities in seated position. RESULTS: Paretic rectus abdominis presented a higher activation than control group (p=0.031 during lower extremities elevation. Obliquus externus abdominis showed a bilateral higher activation during lower extremities elevation than rotation activities (p=0.014 and p=0.002, respectively. There was no difference in extension activities comparison. CONCLUSION: Trunk flexor muscles of hemiparetic subjects demonstrated

  9. Emissões otoacústicas evocadas por estímulos transientes e potencial evocado auditivo de tronco encefálico automático na triagem auditiva neonatal"

    OpenAIRE

    Isabela de Souza Jardim

    2006-01-01

    Com o objetivo de verificar a necessidade de aplicação dos testes de Emissões Otoacústicas Evocadas por Estímulos Transientes (EOAT) e Potencial Evocado auditivo de Tronco Encefálico (PEATEA) combinados e comparar a ocorrência de resultados " Passa" entre os grupos de berçário comum e de UTI-Neonatal, foram avaliados 150 recém-nascidos de berçário comum e 70 recém-nascidos de UTI-Neonatal. Os testes de EOAT e PEATEA apresentaram ocorrência de resposta semelhante quando os grupos foram analisa...

  10. Monitoramento de fungos no ar comparação da quantidade de elementos fúngicos viáveis em dois centros de Transplante de Células-Tronco Hematopoéticas (TCTH) em Porto Alegre

    OpenAIRE

    Caroline Pellicioli Brun

    2011-01-01

    Infecções fúngicas invasivas têm emergido como causa de alta morbimortalidade entre pacientes com neoplasia hematológicas, principalmente os submetidos a transplante de células-tronco hematopoéticas (TCTH). Fungos estão onipresentes na natureza, logo, medidas com o objetivo de reduzir a carga fúngica em ambientes hospitalares têm sido preconizadas. No presente estudo, foi realizada coleta de fungos no ar em dois centros de referência em TCTH do sul do Brasil, que possuem instalações distintas...

  11. Estruturação ex-vivo de vasos sanguíneos a partir da diferenciação de células tronco de coelhos

    OpenAIRE

    Bertanha, Matheus [UNESP

    2011-01-01

    O cultivo de células tronco (CT) e a descoberta de técnicas que promovem a diferenciação tecidual apontam para novos domínios da medicina: a terapia celular e a engenharia de tecidos (ET). As limitações da medicina atual encontram na ET uma nova possibilidade terapêutica, com tratamentos regenerativos ou substitutivos para os tecidos danificados. Dentre as limitações médicas encontram-se as doenças arteriais obstrutivas periféricas (DAOP). A DAOP está presente em 5% da população e cerca de 20...

  12. Interfaces para control cerebral

    OpenAIRE

    Spinelli, Enrique Mario

    2000-01-01

    La función de una interfaz para control cerebral basada en señales de electroencefalograma (EEG), en forma general denominada BCI (Brain control Interface), es establecer un enlace directo entre el cerebro y una máquina, sin utilizar acciones motoras directas. Una BCI permite realizar operaciones simples a partir de la interpretación de las señales de EEG. Su desarrollo está principalmente orientado hacia la ayuda a personas con discapacidades motoras severas, que poseen deterioros en el sist...

  13. Techniques in cerebral protection.

    Science.gov (United States)

    Fanelli, Fabrizio; Bezzi, Mario; Boatta, Emanuele; Passariello, Roberto

    2006-10-01

    Carotid angioplasty and stenting is a valid alternative option to conventional carotid endarterectomy in the treatment of carotid artery stenosis. During the stenting process, however, distal embolization can occur with neurological consequences. To avoid this, cerebral protection devices have been introduced. Three principal types of protection system have been developed: distal balloon occlusion, distal filters and proximal protection with or without reversal of flow. As protection devices became the focus of interest by manufactures and physicians, several trials are going on worldwide to analyze the characteristics of each of them and to evaluate their efficacy to reduce the rate of distal embolization.

  14. Valor del electroencefalograma en la asfixia perinatal

    OpenAIRE

    Desiderio Pozo Lauzán; Ana Camejo Plasencia

    1995-01-01

    La obtención de un electroencefalograma en neonatos con asfixia permitió la detección de elementos subclínicos (eléctricos) que reflejan disfunción cerebral o no. El registro simultáneo del electroencefalograma, con otros parámetros (respiración, electromiograma de los músculos del mentón, motilidad ocular y corporal y electrocardiogramas), constituye lo que se denomina un registro poligráfico. Con este método fue posible identificar los diferentes estadios del ciclo vigilia-sueño (activo, tr...

  15. Cerebral aneurysms – an audit

    African Journals Online (AJOL)

    Enrique

    Abstract. We performed an audit to determine the profile of cerebral aneurysms at the Universitas Hospital Bloem- fontein, the only government hospital with a vascular suite in the Free State and Northern Cape area. Two hun- dred and twenty-three government patients, diagnosed with cerebral aneurysms during the period.

  16. Therapeutic interventions in cerebral palsy.

    Science.gov (United States)

    Patel, Dilip R

    2005-11-01

    Various therapeutic interventions have been used in the management of children with cerebral palsy. Traditional physiotherapy and occupational therapy are widely used interventions and have been shown to be of benefit in the treatment of cerebral palsy. Evidence in support of the effectiveness of the neurodevelopmental treatment is equivocal at best. There is evidence to support the use and effectiveness of neuromuscular electrical stimulation in children with cerebral palsy. The effectiveness of many other interventions used in the treatment of cerebral palsy has not been clearly established based on well-controlled trials. These include: sensory integration, body-weight support treadmill training, conductive education, constraint-induced therapy, hyperbaric oxygen therapy, and the Vojta method. This article provides an overview of salient aspects of popular interventions used in the management of children with cerebral palsy.

  17. Cerebral imaging in pediatrics

    International Nuclear Information System (INIS)

    Gordon, I.

    1998-01-01

    Radioisotope brain imaging has focused mainly on regional cerebral blood flow (rCBF). However the use of ligand which go to specific receptor sites is being introduced in pediatrics, mainly psychiatry. rCBF is potentially available in many institutions, especially with the availability of multi-headed gamma cameras. The use of this technique in pediatrics requires special attention to detail in the manner of data acquisition and handling the child. The interpretation of the rCBF study in a child requires knowledge of normal brain maturation. The major clinical use in pediatrics is epilepsy because of the advances in surgery and the frequency of complex partial seizures. Other indications in pediatric neurology include brain death, acute neurological loss including stroke, language disorders, cerebral palsy, hypertension due to renovascular disease, traumatic brain injury and migraine. There are pediatric physiological conditions in which rCBF has been undertaken, these include anorexia nervosa, autism, Gilles de la Tourette syndrome (GTS) and attention deficit disorder-hyperactivity (ADHD). Research using different ligands to specific receptor sites will also be reviewed in pediatrics

  18. Cerebral imaging in pediatrics

    Energy Technology Data Exchange (ETDEWEB)

    Gordon, I [London, Great Ormond Street Hospital for Children (United Kingdom)

    1998-06-01

    Radioisotope brain imaging has focused mainly on regional cerebral blood flow (rCBF). However the use of ligand which go to specific receptor sites is being introduced in pediatrics, mainly psychiatry. rCBF is potentially available in many institutions, especially with the availability of multi-headed gamma cameras. The use of this technique in pediatrics requires special attention to detail in the manner of data acquisition and handling the child. The interpretation of the rCBF study in a child requires knowledge of normal brain maturation. The major clinical use in pediatrics is epilepsy because of the advances in surgery and the frequency of complex partial seizures. Other indications in pediatric neurology include brain death, acute neurological loss including stroke, language disorders, cerebral palsy, hypertension due to renovascular disease, traumatic brain injury and migraine. There are pediatric physiological conditions in which rCBF has been undertaken, these include anorexia nervosa, autism, Gilles de la Tourette syndrome (GTS) and attention deficit disorder-hyperactivity (ADHD). Research using different ligands to specific receptor sites will also be reviewed in pediatrics.

  19. Cerebral cartography and connectomics.

    Science.gov (United States)

    Sporns, Olaf

    2015-05-19

    Cerebral cartography and connectomics pursue similar goals in attempting to create maps that can inform our understanding of the structural and functional organization of the cortex. Connectome maps explicitly aim at representing the brain as a complex network, a collection of nodes and their interconnecting edges. This article reflects on some of the challenges that currently arise in the intersection of cerebral cartography and connectomics. Principal challenges concern the temporal dynamics of functional brain connectivity, the definition of areal parcellations and their hierarchical organization into large-scale networks, the extension of whole-brain connectivity to cellular-scale networks, and the mapping of structure/function relations in empirical recordings and computational models. Successfully addressing these challenges will require extensions of methods and tools from network science to the mapping and analysis of human brain connectivity data. The emerging view that the brain is more than a collection of areas, but is fundamentally operating as a complex networked system, will continue to drive the creation of ever more detailed and multi-modal network maps as tools for on-going exploration and discovery in human connectomics. © 2015 The Author(s) Published by the Royal Society. All rights reserved.

  20. Cerebral Gluconeogenesis and Diseases

    Science.gov (United States)

    Yip, James; Geng, Xiaokun; Shen, Jiamei; Ding, Yuchuan

    2017-01-01

    The gluconeogenesis pathway, which has been known to normally present in the liver, kidney, intestine, or muscle, has four irreversible steps catalyzed by the enzymes: pyruvate carboxylase, phosphoenolpyruvate carboxykinase, fructose 1,6-bisphosphatase, and glucose 6-phosphatase. Studies have also demonstrated evidence that gluconeogenesis exists in brain astrocytes but no convincing data have yet been found in neurons. Astrocytes exhibit significant 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 activity, a key mechanism for regulating glycolysis and gluconeogenesis. Astrocytes are unique in that they use glycolysis to produce lactate, which is then shuttled into neurons and used as gluconeogenic precursors for reduction. This gluconeogenesis pathway found in astrocytes is becoming more recognized as an important alternative glucose source for neurons, specifically in ischemic stroke and brain tumor. Further studies are needed to discover how the gluconeogenesis pathway is controlled in the brain, which may lead to the development of therapeutic targets to control energy levels and cellular survival in ischemic stroke patients, or inhibit gluconeogenesis in brain tumors to promote malignant cell death and tumor regression. While there are extensive studies on the mechanisms of cerebral glycolysis in ischemic stroke and brain tumors, studies on cerebral gluconeogenesis are limited. Here, we review studies done to date regarding gluconeogenesis to evaluate whether this metabolic pathway is beneficial or detrimental to the brain under these pathological conditions. PMID:28101056

  1. Cerebral Gluconeogenesis and Diseases.

    Science.gov (United States)

    Yip, James; Geng, Xiaokun; Shen, Jiamei; Ding, Yuchuan

    2016-01-01

    The gluconeogenesis pathway, which has been known to normally present in the liver, kidney, intestine, or muscle, has four irreversible steps catalyzed by the enzymes: pyruvate carboxylase, phosphoenolpyruvate carboxykinase, fructose 1,6-bisphosphatase, and glucose 6-phosphatase. Studies have also demonstrated evidence that gluconeogenesis exists in brain astrocytes but no convincing data have yet been found in neurons. Astrocytes exhibit significant 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 activity, a key mechanism for regulating glycolysis and gluconeogenesis. Astrocytes are unique in that they use glycolysis to produce lactate, which is then shuttled into neurons and used as gluconeogenic precursors for reduction. This gluconeogenesis pathway found in astrocytes is becoming more recognized as an important alternative glucose source for neurons, specifically in ischemic stroke and brain tumor. Further studies are needed to discover how the gluconeogenesis pathway is controlled in the brain, which may lead to the development of therapeutic targets to control energy levels and cellular survival in ischemic stroke patients, or inhibit gluconeogenesis in brain tumors to promote malignant cell death and tumor regression. While there are extensive studies on the mechanisms of cerebral glycolysis in ischemic stroke and brain tumors, studies on cerebral gluconeogenesis are limited. Here, we review studies done to date regarding gluconeogenesis to evaluate whether this metabolic pathway is beneficial or detrimental to the brain under these pathological conditions.

  2. ORIGIN OF THE FACIAL ARTERY FROM THE LINGUAL-FACIAL TRUNK AND ITS COURSE THROUGH THE SUBMANDIBULAR SALIVARY GLAND: A CASE REPORT. Origen de la arteria facial desde el tronco lingual-facial y su curso a través de la glándula salival submandibular: informe

    Directory of Open Access Journals (Sweden)

    Srinivasa Rao Sirasanagandla

    2016-03-01

    Full Text Available La disección cuidadosa del tercio posterior de la parte superficial de la glándula salival submandibular es uno de los pasos quirúrgicos esenciales en la extirpación endoscópica glandular, evitando daños en la arteria facial. Un buen conocimiento de la poco común relación entre la arteria facial y la glándula salival submandibular es de vital importancia para llevar a cabo de forma eficiente y segura la extirpación de la glándula submandibular. Las variaciones del patrón de ramificación de la arteria facial son bien conocidas y han sido expuestas en el pasado. Sin embargo, las variaciones en su origen y trayectoria son poco frecuentes. Durante una rutinaria disección de cabeza y cuello para los estudiantes universitarios de Medicina, observamos la inusual trayectoria de la arteria facial en el triángulo digástrico derecho en un cadáver de un varón de origen indio de aproximadamente 60 años. La arteria facial derecha se originó de la común lingual-facial del tronco por encima del nivel del asta mayor del hueso hioides, y luego atravesar a través de la sustancia de la parte superficial de la glándula submandibular, sin la formación de un bucle. Después la arteria entraba en la cara por el ángulo anteroinferior del masetero. A continuación, en su trayectoria intraglandular, esta arteria mostraba pequeñas ramificaciones glandulares.  Careful dissection of the posterior one third of the superficial part of the submandibular salivary gland is one of the essential surgical steps in endoscopic glandular excision, to avoid injury to the facial artery. A sound knowledge of unusual relationship of the facial artery with the submandibular salivary gland is essentially important to perform the safe and efficient submandibular gland excision. Different types of variations in the branching pattern of the facial artery have been reported in the past. However, variations in the origin and course of the facial artery are very rare

  3. Un caso de infeccion humana por cisticerco racemoso cerebral de localizacion parenquimatosa en Valdivia, Chile A case of human cerebral infection by parenchymal racemose cysticercus in Valdivia, Chile

    Directory of Open Access Journals (Sweden)

    Eduardo Ortega

    1991-06-01

    Full Text Available Se presenta un caso clínico de infección por cisticerco racemoso cerebral de localización parenquimatosa en un paciente de la ciudad de Valdivia (Chile cuyo diagnóstico definitivo se efectuó a través del estudio morfológico del parásito. Se discute brevemente la escasa frecuencia de la localización parenquimatosa del cisticerco racemoso, así como su diagnóstico diferencial con otros estados larvarios de cestodos que desarrollan en el sistema nervioso.A clinical case of cerebral infection by parenchymal racemose cysticercus, diagnosed by means of morphological characteristics in a patient of Valdivia city is described. The rare frequency of parenquimal location of racemose cysticercus as well as its differential diagnosis with other larval stages of cestodes that develop in the brain and its treatment are discussed.

  4. Células-tronco de origem hematopoéticas: expansão e perspectivas de uso terapêutico Hematopoietic stem cells: expansion and perspectives for therapeutic use

    Directory of Open Access Journals (Sweden)

    Eliana S. F. W. Abdelhay

    2009-05-01

    Full Text Available A célula-tronco hematopoética (CTH tem um enorme potencial para reconstituir o sistema hematopoético, o que permitiu o desenvolvimento de estratégias de terapias celulares para doenças neoplásicas ou não. Em paralelo com os avanços clínicos, estudos sobre os mecanismos moleculares que levam as células-tronco hematopoéticas a decidir pela autorrenovação, diferenciação ou apoptose têm contribuído para o conhecimento de como controlar a cinética da CTH. Esta revisão tenta descrever como estes novos avanços podem ser utilizados no desenvolvimento de estratégias de expansão das CTHs para uso terapêutico.Hematopoietic stem cells (HSCs have the potential for reconstituting the hematopoietic system a characteristic that has enabled the development of cell based therapies for neoplastic and non-malignant diseases. In parallel with these clinical advances, elucidation of molecular mechanisms controlling self-renewal, differentiation or apoptosis have contributed to our understanding of the molecular events that control HSC kinetics. This review focuses on how these advances can be translated in new strategies for HSC expansion and their use in therapies.

  5. Consenso brasileiro em transplante de células-tronco hematopoéticas: comitê de hemoglobinopatias Brazilian consensus meeting on stem cell transplantation: hemoglobinopathies comittee

    Directory of Open Access Journals (Sweden)

    Belinda P. Simões

    2010-05-01

    Full Text Available Os distúrbios hereditários das hemoglobinas são as doenças genéticas mais frequentes do homem e mais difundidas no mundo, abrangendo sobretudo continentes como África, Américas, Europa e extensas regiões da Ásia. Estima-se que haja 270 milhões de portadores de hemoglobinopatias no mundo, dos quais 80 milhões são portadores de talassemia. Aproximadamente 60 mil crianças nascem anualmente no mundo com talassemia e 250 mil com anemia falciforme, dando uma frequência de 2,4 crianças afetadas para cada 1.000 nascimentos. No Brasil, a doenca falciforme é a doença hereditária monogênica mais comum, estimando-se que haja entre 20 a 30 mil pacientes portadores desta doenca. O transplante de células-tronco hematopoéticas alogênico (TCTH alo é atualmente a única modalidade terapêutica capaz de curar pacientes com hemoglobinopatias. Neste artigo discutiremos os dados disponíveis na literatura e sugerimos os critérios para a indicação do TCTH nas hemoglobinopatias.Hemoglobinopathies are the most prevalent genetic diseases in man. Most cases are described in Europe, Africa and in the Americas. About 270 million hemoglobinopathy carriers are alive today with 80 million being carriers of thalassemia. We estimate that, throughout the world, about 60,000 children are born annually with thalassemia and 250,000 with sickle cell disease with an estimated frequency of 2.4 children in every 1000 births. Sickle cell disease is the most common monogenic hereditary disease in Brazil with a total of from 20,000 to 30,000 patients. Allogeneic stem cell transplantation is the only curative approach. Here we describe published data and propose criteria to indicate stem cell transplantation in thalassemia and sickle cell disease patients.

  6. Transplante de células-tronco hematopoéticas e leucemia mieloide aguda: diretrizes brasileiras Hematopoietic stem cells transplantation and acute myeloid leukemia: Brazilian guidelines

    Directory of Open Access Journals (Sweden)

    Lucia Mariano R. Silla

    2010-05-01

    Full Text Available O objetivo deste trabalho foi definir diretrizes para a indicação do transplante de células-tronco hematopoéticas (TCTH no tratamento da leucemia mieloide aguda (LMA no Brasil. O papel do TCTH no tratamento da LMA foi discutido pelosautores e apresentado para a Sociedade Brasileira de Transplante de Medula Óssea na reunião sobre Diretrizes Brasileiras para o TCTH, que o ratificou. Este consenso foi baseado na revisão da literatura internacional e na experiência brasileira em TCTH para o tratamento da LMA. O tratamento ideal para leucemia mieloide aguda em primeira remissão completa (1RC ainda não está definido. Há consenso na indicação do TCTH alogênico, com condicionamento mieloablativo, para pacientes que apresentem alterações citogenéticas consideradas de alto risco. O TCTH alogênico não está indicado na 1RC para pacientes de baixo risco citogenético e, aparentemente, o TCTH alogênico, autólogo ou a quimioterapia de consolidação são equivalentes para os pacientes de risco intermediário.The objective of this work was to define guidelines for the indication of hematopoietic stem cells transplantation (HSCT in the treatment of acute myeloid leukemia (AML in Brazil. The role of HSCT in the treatment of AML was discussed by the authors and presented to the Brazilian Society of Bone Marrow Transplantation in a meeting to formulate and ratify the Brazilian Guidelines on HSCT. This consensus was based on a review of international publications and on the Brazilian experience in HSCT for the treatment of AML. The optimal treatment for AML in first complete remission (1CR has not been defined yet. There is consensus on the indication of allogeneic HSCT with myeloablative conditioning for patients who present high risk cytogenetic changes. Allogeneic HSCT is not indicated for low cytogenetic risk 1RC patients and, apparently, allogeneic and autologous HSCT and consolidation chemotherapy are similar for intermediate risk

  7. Diferenciação de células-tronco mesenquimais derivadas do tecido adiposo em cardiomiócitos

    Directory of Open Access Journals (Sweden)

    Pablo Herthel Carvalho

    2013-01-01

    Full Text Available FUNDAMENTO: O potencial de renovação e proliferação dos cardiomiócitos, in vivo, é pequeno, e por isso, o músculo cardíaco apresenta limitada capacidade de repor células perdidas. Na tentativa de minimizar os danos oriundos de lesões hipóxico-isquêmicas e daquelas que acometem o sistema de condução do coração, a terapia celular com células-tronco mesenquimais (MSC vem sendo utilizada, inclusive com cardiomiócitos diferenciados a partir de MSC. OBJETIVO: O presente trabalho comparou três protocolos distintos de indução de diferenciação objetivando a sugestão de um método viável para a diferenciação de maior número de células funcionais que expressem fenótipo cardiomiogênico. MÉTODOS: Culturas de MSC obtidas de tecido adiposo de ratos jovens da linhagem Lewis transgênicos para proteína verde fluorescente (GFP foram submetidos a três diferentes meios de diferenciação cardiogênica: Planat-Bérnard, 5-azacitidina e meio Planat-Bérnard + 5-azacitidina e observadas quanto a expressão de marcadores celulares cardíacos. RESULTADOS: Nos três protolocos utilizados observou-se formação da proteína alfa-actinina sarcomérica no citoesqueleto das células submetidas à diferenciação, expressão de conexina 43 na membrana nuclear e citoplasmática e formação de gap junctions, necessárias para a propagação do impulso elétrico no miocárdio, contudo, em nenhum protocolo foi observada contração espontânea das células submetidas à diferenciação cardiogênica. CONCLUSÃO: A indução com 5-azacitidina proporcionou diferenciação celular cadiomiogênica efetiva e similar à encontrada com o meio Planat-Bénard e, por ser um protocolo mais simples, rápido e com menor custo torna-se o método de eleição.

  8. Cerebral toxoplasmosis in AIDS

    International Nuclear Information System (INIS)

    Christ, F.; Steudel, H.; Klotz, D.; Bonn Univ.; Bonn Univ.

    1986-01-01

    Since 1982 (Hauser and co-workers), literature has reported focal cerebral tissue charges in AIDS patients whose diagnosis was unclear at first but which could be identified finally as florid toxoplasmosis encephalitis by biopsy and autopsy. It was found that the value of otherwise reliable serological tests (KBR, Sabin-Feldmann tests, etc.) is questionable in patients with severely impaired or incompetent immune systems, and, in particular, that a negative or uncharacteristic test result may not preclude any opportunistic infection process. Furthermore, isolation of Toxoplasma gondii or specific antibodies from the cerebrospinal fluid will be successful in exceptional cases only. In patients with AIDS or lymphadenopathy syndrome, the differential diagnosis will have to include - first and foremost - reactivated toxoplasma infection (not newly acquired, as a rule) if central neurological symptoms occur. (orig.) [de

  9. Cerebral white matter hypoplasia

    International Nuclear Information System (INIS)

    Dietrich, R.B.; Shields, W.D.; Sankar, R.

    1990-01-01

    This paper demonstrates the MR imaging findings in children with cerebral white matter hypoplasia (CWMH). The MR studies of four children, aged 3-7 y (mean age, 2.3 y) with a diagnosis of CWMH were reviewed. In all cases multiplanar T1-weighted and T2-weighted spin-echo images were obtained. All children had similar histories of severe developmental delay and nonprogressive neurologic deficits despite normal gestational and birth histories. In two cases there was a history of maternal cocaine abuse. Autopsy correlation was available in one child. The MR images of all four children demonstrated diffuse lack of white matter and enlarged ventricles but normal-appearing gray matter. The corpus callosum, although completely formed, was severely thinned. There was no evidence of gliosis or porencephaly, and the distribution of myelin deposition was normal for age in all cases. Autopsy finding in one child correlated exactly with the MR finding

  10. Multiple cerebral hydatid cysts

    Energy Technology Data Exchange (ETDEWEB)

    Banzo, J.; Pina, J.I.; Abos, M.D.; Rios, G.; Garcia, D.; Marin, F.; Diaz, F.J.

    1984-12-01

    A 39-year-old woman was admitted to hospital with headaches, vomiting, psychic impairment and diplopia. Three hydatid cysts of the lung had been previously removed. An avascular mass in the left hemisphere with left-to-right displacement of the anterior cerebral arteries was noted during a brain angioscintigraphy. A cerebralthrombosis (CT) brain scan showed two cystic lesions situated in the left-frontal and occipital regions. A CT abdominal scan showed multiple cysts in the liver, spleen and both kidneys. At operation, two brain cysts were totally extirpated without rupture. The definite pathological diagnosis was secondry hydatid cysts. The headaches, vomiting and diplopia were persistent in the post-operative period. Seven days after the operation, a CT brain scan showed an infratenrorial cyst. The patient rejected any surgical intervention.

  11. Corrección quirúrgica del síndrome de Bland-White-Garland en un adulto joven

    Directory of Open Access Journals (Sweden)

    Filiberto Villanueva-Rustrián

    2009-01-01

    Full Text Available Presentamos el caso de un varón de 21 años de edad, el cual ingresa a nuestra institución a causa de disnea y descubrimiento fortuito de soplo continuo. Terminado el estudio correspondiente, diagnosticamos la presencia de una coronariopatía congénita del tipo nacimiento anómalo de la arteria coronaria izquierda con origen en el tronco de la arteria pulmonar (síndrome de Bland-White-Garland. El tratamiento elegido durante el acto quirúrgico fue la ligadura de la coronaria anómala en la parte exterior del tronco de la pulmonar, complementando con la anastomosis de la arteria mamaria interna izquierda a la descendente anterior. No se presentaron complicaciones en el procedimiento ni en el postoperatorio inmediato. Un año después, el paciente se encuentra asintomático. Teniendo en cuenta que se trata de una malformación de poca frecuencia en esta edad y que la experiencia quirúrgica actual no es suficiente, consideramos que el manejo quirúrgico elegido en este caso es una alternativa segura en aquellos pacientes en los que no sea posible una corrección anatómica total.

  12. The importance of bilateral monitoring of cerebral oxygenation (NIRS): Clinical case of asymmetry during cardiopulmonary bypass secondary to previous cerebral infarction.

    Science.gov (United States)

    Matcan, S; Sanabria Carretero, P; Gómez Rojo, M; Castro Parga, L; Reinoso-Barbero, F

    2018-03-01

    Cerebral oximetry based on near infrared spectroscopy (NIRS) technology is used to determine cerebral tissue oxygenation. We hereby present the clinical case of a 12-month old child with right hemiparesis secondary to prior left middle cerebral artery stroke 8 months ago. The child underwent surgical enlargement of the right ventricular outflow tract (RVOT) with cardiopulmonary bypass. During cardiopulmonary bypass, asymmetric NIRS results were detected between both hemispheres. The utilization of multimodal neuromonitoring (NIRS-BIS) allowed acting on both perfusion pressure and anesthetic depth to balance out the supply and demand of cerebral oxygen consumption. No new neurological sequelae were observed postoperatively. We consider bilateral NIRS monitoring necessary in order to detect asymmetries between cerebral hemispheres. Although asymmetries were not present at baseline, they can arise intraoperatively and its monitoring thus allows the detection and treatment of cerebral ischemia-hypoxia in the healthy hemisphere, which if undetected and untreated would lead to additional neurological damage. Copyright © 2017 Sociedad Española de Anestesiología, Reanimación y Terapéutica del Dolor. Publicado por Elsevier España, S.L.U. All rights reserved.

  13. Vivenciando a sobrecarga ao vir-a-ser um cuidador familiar de pessoa com acidente vascular cerebral (AVC: análise do conhecimento Viviendo la sobrecarga al convertirse en cuidador familiar de personas con accidente cerebrovascular: análisis del conocimiento Living the burden in becoming a family caregiver for a cerebrovascular accident survivor: knowledge analysis

    Directory of Open Access Journals (Sweden)

    Silvia Cristina Mangini Bocchi

    2004-02-01

    Full Text Available Trata-se de trabalho do tipo bibliográfico com a finalidade de fazer uma análise temática da produção do conhecimento em periódicos, acerca da sobrecarga em cuidadores familiares de pessoas com Acidente Vascular Cerebral (AVC. O corpus de análise reuniu artigos localizados nas décadas de 80 e 90, a partir das bases de dados Medline, Lilacs e Cinahl. A análise de conteúdo foi o referencial metodológico que permitiu organizar todo o conhecimento, em um corpo de categorias e subcategorias, denominadas: Categoria 1 - As seqüelas do AVC gerando sobrecarga; Categoria 2 - Aspectos gerando sobrecarga, congregando as subcategorias: o isolamento social, as mudanças e as insatisfações conjugais, as dificuldades financeiras e os déficits na saúde física e no autocuidado do cuidador; Categoria 3 - Outras análises relacionadas à sobrecarga em cuidadores familiares.Se trata de un trabajo del tipo bibliográfico con la finalidad de hacer un análisis temático de producción del conocimiento en revistas, sobre la carga de cuidadores familiares de personas con Accidente Cerebrovascular (ACV. El corpus de análisis reunió artículos realizados en las décadas de 80 y 90 a partir de las bases de datos Medline, Lilacs y Cinahl. El análisis de contenido fue el referencial metodológico que permitió organizar todo el conocimiento en un cuerpo de categorías y subcategorías denominadas: categoría 1 - Las secuelas del ACV generando carga, Categoría 2 - Aspectos generadores de la carga que congregan las subcategorías: el aislamiento social, los cambios y las insatisfacciones conyugales, las dificultades financieras y los déficit en la salud física y en el cuidado consigo mismo, Categoría 3 - Otros análisis sobre la carga de cuidadores familiares de personas con ACV.This bibliographical research aims to carry out a thematic analysis of knowledge production in periodicals, about the burden placed on family caregivers of Cerebrovascular

  14. Cerebral Laterality and Verbal Processes

    Science.gov (United States)

    Sherman, Jay L.; And Others

    1976-01-01

    Research suggests that we process information by way of two distinct and functionally separate coding systems. Their location, somewhat dependent on cerebral laterality, varies in right- and left-handed persons. Tests this dual coding model. (Editor/RK)

  15. Hydrocephalus in cerebral venous thrombosis

    NARCIS (Netherlands)

    Zuurbier, Susanna M.; van den Berg, René; Troost, Dirk; Majoie, Charles B.; Stam, Jan; Coutinho, Jonathan M.

    2015-01-01

    Increased intracranial pressure is common in cerebral venous thrombosis (CVT), but hydrocephalus is rarely reported in these patients. We examined the frequency, pathophysiology and associated clinical manifestations of hydrocephalus in patients with CVT admitted to our hospital between 2000 and

  16. Cerebral infarcts resulting from trauma

    International Nuclear Information System (INIS)

    Busch, G.

    1985-01-01

    Vascular occlusions due to cerebral trauma have always been regarded as great rarities. However, we have found hypo-dense foci of vascular distribution in 3.5% of 3500 CT examinations for trauma during the late phase. Lesions in the vascular territory of the posterior cerebral artery are usually the result of supratentorial pressure rise from epidural and subdural haematomas, leading to compression of the vessels against the edge of the tentorium. Typical infacts in the territory of the medial and anterior cerebral arteries were found only rarely by CT after cerebral trauma. Infarcts at the watersheds between the three vascular territories were found with surprising frequency and small infarcts were found in the basal ganglia. It is assumed that these were due to ischaemic or hypoxic events due to cardiac or pulmonary complications during the initial phase. (orig.) [de

  17. Cerebral Cavernous Malformation and Hemorrhage

    Science.gov (United States)

    ... Text Size: SMALL • LARGE Cerebral Cavernous Angioma and Hemorrhage By Jack Hoch; Reviewed by Dr. Issam Awad ... for years, the mechanism by which these lesions hemorrhage remains poorly understood. Hemorrhage Types Since cavernous angiomas ...

  18. MRI of cerebral alveolar echinococcosis

    International Nuclear Information System (INIS)

    Tunaci, M.; Tunaci, A.; Engin, G.; Oezkorkmaz, B.; Ahishali, B.; Rozanes, I.

    1999-01-01

    Cerebral alveolar echinococcosis is rare. We report a case with multiple intracranial masses which show cauliflower-like contrast enhancement pattern on MRI. The lesions originated from hepatic involvement with invasion of the inferior vena cava. (orig.)

  19. Learn More About Cerebral Palsy

    Centers for Disease Control (CDC) Podcasts

    2008-03-30

    This podcast describes the causes, preventions, types, and signs and symptoms of cerebral palsy.  Created: 3/30/2008 by National Center on Birth Defects and Developmental Disabilities.   Date Released: 3/21/2008.

  20. Parálisis cerebral :

    OpenAIRE

    Cabrero Izquierdo, María del Carmen

    2012-01-01

    Se aborda el tema de la parálisis cerebral definiendo qué es, clasificando los tipos de parálisis dependiendo de la afectación y las características principales. Se explican algunos de sus tratamientos, se dan sistemas alternativos y/o aumentativos de comunicación para un alumno con PC (parálisis cerebral).

  1. Cerebral candidiasis. Computed tomography appearance

    International Nuclear Information System (INIS)

    Chaabane, M.; Ladeb, M.F.; Bouhaouala, M.H.; Ben Hammouda, M.; Ataalah, R.; Gannouni, A.; Krifa, H.

    1989-01-01

    A three year old child who had been suffering from oral candidiasis since the age of 1 year presented with osteitis of the clavicle, 2 cerebral frontal abscesses and an occipital abscess which extended across the calvaria and was associated with osteolysis. Histological and microbiological studies following surgery confirmed the diagnosis of candidiasis in this girl who was found to have IgA immunodefinciency. The authors report the computed tomographic appearance of the cerebral lesions and review the literature. (orig.)

  2. Cerebral candidiasis. Computed tomography appearance

    Energy Technology Data Exchange (ETDEWEB)

    Chaabane, M.; Ladeb, M.F.; Bouhaouala, M.H.; Ben Hammouda, M.; Ataalah, R.; Gannouni, A.; Krifa, H.

    1989-07-01

    A three year old child who had been suffering from oral candidiasis since the age of 1 year presented with osteitis of the clavicle, 2 cerebral frontal abscesses and an occipital abscess which extended across the calvaria and was associated with osteolysis. Histological and microbiological studies following surgery confirmed the diagnosis of candidiasis in this girl who was found to have IgA immunodefinciency. The authors report the computed tomographic appearance of the cerebral lesions and review the literature. (orig.).

  3. Estructura celular del xilema de la rama para establecer una metodología de caracterización tecnológica del tronco de árboles en áreas naturales protegidas

    OpenAIRE

    Valderrama Freyre, Heiter

    2008-01-01

    A methodology based on the knowledge of the cell structure of xylem of branches of 10 cm diameter for technological characterization of wood from tree stem is proposed in this research, which can be used in forest species from natural protected areas without felling down the whole tree. Data were gathered from trees of ten forest species belonging to the “Arboretum Jardín Botánico” of the National University of the Peruvian Amazon; description of cell structure was carried out in the laborato...

  4. Overexpression of metallothioneins, stem cell niches and field cancerization in experimental gliomagenesis Superexpresión de metalotioneínas, nichos de células madre y campos de cancerización en gliomagénesis experimental A superexpressão de metalotioneínas em células-tronco de áreas cancerígenas na gênese de glioma experimental

    Directory of Open Access Journals (Sweden)

    Julio César Fernandes da Silva

    2009-12-01

    mutación de las células madres. Objetivo: estudio de la expresión de MT en el modelo experimental de la N-etil N-nitrosoureia (ENU y establecer un modelo experimental para el seguimiento de las células madre en la oncogénesis glioma. MÉTODOS: treinta y seis ratas machos Wistar fueron divididas en dos grupos, un grupo de animales experimentales fue tratado dentro de 24 horas después del nacimiento (ratas neonatas con una dosis única de ENU (40 mg/kg. Los animales del Grupo Control fueron inyectados con el mismo volumen de solución salina. Los animales del Grupo Experimental fueron subdivididos en tres grupos de acuerdo con el tiempo de eutanasia, así como sigue: el Grupo G1 sufrió eutanasia con la edad de 30 días; el Grupo G2, con 180 días y el Grupo G3, después del surgimiento de señales de existencia de tumor del sistema nervioso, con un promedio de edad de 321 días. La detección inmunohistoquímica de la proteína MT en cortes de médula espinal fijados en acetona fría y embebidos en parafina fue realizada por el método del complejo estreptovidina-avidina-biotina-inmuno peroxidase. RESULTADOS: por medio de modelos experimentales de gliomagénesis inducida por la ENU fue observado que es posible detectar células madre de tumor putativo en el inicio de la oncogénesis, para realizar un proceso de cancerización de campo y observar una relación morfológica entre células positivas para MT y vasos sanguíneos. CONCLUSIÓN: este modelo experimental reproductible permite otros estudios involucrando el origen, desarrollo y factores reguladores de la gliomatogénesis.INTRODUÇÃO: células-tronco podem originar e perpetuar o crescimento tumoral, porém são pouco conhecidas na gliomagênese. As metalotioneínas (MTs são proteínas envolvidas na oncogênese, e sua a imunopositividade pode ser utilizada como marcador de mutação de células-tronco. Objetivo: estudar a expressão de MT no modelo experimental da ENU e estabelecer um modelo experimental para

  5. Cerebral trypanosomiasis and AIDS

    Directory of Open Access Journals (Sweden)

    Antunes Apio Claudio Martins

    2002-01-01

    Full Text Available A 36 year-old black female, complaining of headache of one month's duration presented with nausea, vomiting, somnolence, short memory problems, loss of weight, and no fever history. Smoker, intravenous drugs abuser, promiscuous lifestyle. Physical examination: left homonimous hemianopsia, left hemiparesis, no papilledema, diffuse hyperreflexia, slowness of movements. Brain CT scan: tumor-like lesion in the splenium of the corpus calosum, measuring 3.5 x 1.4 cm, with heterogeneous enhancing pattern, sugesting a primary CNS tumor. Due to the possibility of CNS infection, a lumbar puncture disclosed an opening pressure of 380 mmH(20; 11 white cells (lymphocytes; glucose 18 mg/dl (serum glucose 73 mg/dl; proteins 139 mg/dl; presence of Trypanosoma parasites. Serum Elisa-HIV tests turned out to be positive. Treatment with benznidazole dramatically improved clinical and radiographic picture, but the patient died 6 weeks later because of respiratory failure. T. cruzi infection of the CNS is a rare disease, but we have an increasing number of cases in HIV immunecompromised patients. Diagnosis by direct observation of CSF is uncommon, and most of the cases are diagnosed by pathological examination. It is a highly lethal disease, even when properly diagnosed and treated. This article intends to include cerebral trypanosomiasis in the differential diagnosis of intracranial space-occupying lesions, especially in immunecompromised patients from endemic regions.

  6. Pseudotumoral delayed cerebral radionecrosis

    International Nuclear Information System (INIS)

    Ciaudo-Lacroix, C.; Lapresle, J.

    1985-01-01

    A 60 year-old woman with a scalp epithelioma underwent radiotherapy, the dose being 57 Gray. A first epileptic seizure occurred twenty months later. Neurological examination revealed signs of left hemisphere involvement. γEG, angiography, CT scans, demonstrated a pseudotumoral avascular process. On account of the localisation, the patient being right-handed, no surgical procedure was performed. In spite of corticotherapy and anticonvulsive treatment, seizures recurred and neurological signs slowly progressed. The patient died, 22 months after the first seizure, of an associated disseminated carcinoma with cachexia. Neuropathological examination showed a massive lesion presenting all the features of delayed radionecrosis in the left hemisphere: situated mainly in the white matter; numerous vascular abnormalities; wide-spread demyelination; disappearance of oligoglial cells. The Authors recall the clinical and anatomical aspects of this condition for which the only successful treatment is surgical removal when location and size of the lesion permit. Finally, the mechanisms which have been proposed to explain this delayed cerebral radionecrosis are discussed [fr

  7. Pseudotumoral delayed cerebral radionecrosis

    Energy Technology Data Exchange (ETDEWEB)

    Ciaudo-Lacroix, C; Lapresle, J [Centre Hospitalier de Bicetre, 94 - Le Kremlin-Bicetre (France)

    1985-01-01

    A 60 year-old woman with a scalp epithelioma underwent radiotherapy, the dose being 57 Gray. A first epileptic seizure occurred twenty months later. Neurological examination revealed signs of left hemisphere involvement. ..gamma..EG, angiography, CT scans, demonstrated a pseudotumoral avascular process. On account of the localisation, the patient being right-handed, no surgical procedure was performed. In spite of corticotherapy and anticonvulsive treatment, seizures recurred and neurological signs slowly progressed. The patient died, 22 months after the first seizure, of an associated disseminated carcinoma with cachexia. Neuropathological examination showed a massive lesion presenting all the features of delayed radionecrosis in the left hemisphere: situated mainly in the white matter; numerous vascular abnormalities; wide-spread demyelination; disappearance of oligoglial cells. The Authors recall the clinical and anatomical aspects of this condition for which the only successful treatment is surgical removal when location and size of the lesion permit. Finally, the mechanisms which have been proposed to explain this delayed cerebral radionecrosis are discussed.

  8. Transplante autólogo de células-tronco hematopoiéticas sem uso de hemocomponentes Hematopoietic stem cell transplantation without the use of blood transfusions

    Directory of Open Access Journals (Sweden)

    Roberto L. Silva

    2006-06-01

    Full Text Available O transplante de células-tronco hematopoéticas (TCTH é terapia consolidada para tratamento de algumas doenças onco-hematológicas, e o suporte transfusional tem, tradicionalmente, sido fundamental para a realização do mesmo. Descrevemos um caso de paciente testemunha de Jeová, portadora de linfoma Hodgkin em terceira remissão parcial, que foi submetida a quimioterapia de altas doses com regime de condicionamento clássico (carmustina, etoposide, citarabina, melfalan e posterior infusão de células-tronco hematopoéticas sem o uso de hemocomponentes. A paciente apresentou toxicidade hematológica inerente ao procedimento e medidas clínicas de suporte tais como a utilização de eritropoetina, IL 11, antifibrinolítico, entre outras, foram utilizadas na tentativa de minimizar o risco de sangramento e anemia grave. O curso do transplante transcorreu sem complicações graves. Este caso demonstra que o transplante autólogo de células-tronco hematopoéticas sem o uso de hemocomponentes é factível em situações especiais, onde há clara expressão do desejo do paciente associado a condições clínicas favoráveis e acompanhamento médico especialista rigoroso.Hematopoietic stem cell transplantation (HSCT is standard therapy for the treatment of some hematological neoplasms and support with blood transfusions is considered essential for this procedure. Herein we describe the case of a Jeovah's witness who had Hodgkin's lymphoma in third partial remission and was submitted to high-dose chemotherapy using a classic conditioning regimen (carmustine, etoposide, cytarabine, melphalan with posterior infusion of autologous peripheral blood stem cells without the use of blood transfusions. The patient had the usual degree of hematological toxicity and was treated with clinical support measures, such as the use of erythropoietin, IL-11 and antifibrinolytics, with the goal of minimizing the risk of bleeding and serious anemia. The HSTC coursed

  9. Potencial terapêutico das células-tronco de medula óssea no tratamento da epilepsia Therapeutic potential of bone marrow stem cells in epilepsy treatment

    Directory of Open Access Journals (Sweden)

    Maria Julia M. Carrion

    2009-05-01

    Full Text Available Epilepsia é uma patologia bastante prevalente no nosso meio. Há um número significativo de pacientes que não obtém resposta com a terapêutica medicamentosa, o que motivou a pesquisa de novas terapêuticas. O conceito de neurogênese no cérebro adulto, hoje já amplamente conhecida, principalmente a que ocorre na zona subventricular e na zona subgranular do giro denteado, motivou o desenvolvimeto de técnicas que aproveitassem esse mecanismo na tentativa de obtenção de efeitos antiepileptogênicos e reparadores. A maior parte dos estudos em vigência hoje, e que buscam tal finalidade, trabalha o uso de transplante de células progenitoras neurais ou de células fetais em modelos experimentais. No entanto, a terapêutica com células-tronco de medula óssea parece bastante interessante e promissora. Em doenças neurológicas nas quais os danos são frequentemente irreversíveis, as estratégias regenerativas podem representar um novo caminho. Em nosso laboratório, temos estudado o potencial terapêutico de células-tronco da medula óssea no controle de crises espontâneas recorrentes associadas ao modelo da pilocarpina com resultados excelentes. Também já está em andamento o primeiro estudo em humanos utilizando células-tronco de medula óssea para o tratatamento da epilepsia.Epilepsy is a prevalent pathology. A significative number of patients do not achieve an adequate response to pharmacological therapy. This observation has motivated the search for new strategies. The now well known concept of neurogenesis in the adult brain, in particular in the subventricular and dentate gyrus subgranular zones, has encouraged the development of strategies that might control this mechanism in order to obtain either antiepileptogenic or repair effects. Most studies focus on the transplantation of neural progenitor or fetal cells in experimental models, although bone marrow stem cell therapy is promising. In neurological diseases in which damage

  10. Disfunção intestinal em pacientes com lesão cerebral decorrente de acidente vascular cerebral e traumatismo craniencefálico: estudo retrospectivo de uma série de casos

    Directory of Open Access Journals (Sweden)

    Cinthia Carlos Dourado

    2012-01-01

    Full Text Available La disfunción del intestino es una queja común entre los pacientes con daño cerebral debido a una lesión cerebral traumática y accidente cerebrovascular. Este estudio tuvo como objetivo investigar la prevalencia de disfunción del intestino (incontinencia y constipación en pacientes con daño cerebral debido a una lesión cerebral traumática y accidente cerebrovascular admitidos para la rehabilitación. Este es un estudio retrospectivo de una serie de casos a partir del análisis de los datos de 138 expedientes de los pacientes ingresados en el primer semestre de 2009. La prevalencia de disfunción del intestino fue de 41%, siendo 33 (24% incontinencia anal y 37 (27%, constipación. El comprometimiento motor, ayuda a la movilidad, cambios en la memoria y la comunicación se asocian con la presencia de la incontinencia anal. La prevalencia de disfunción del intestino es alta en esta población, identificar en forma temprana los factores relacionados, y promover el reentrenamiento intestinal pueden ayudar a mejorar la calidad de sus vidas.

  11. Potencial de transdiferenciação neural das células-tronco mesenquimais da medula óssea de equino

    Directory of Open Access Journals (Sweden)

    Leandro Maia

    2012-05-01

    Full Text Available Os primeiros estudos demonstrando o potencial de trandiferenciação neural das células-tronco mesenquimais (CTMs provenientes da medula óssea (MO foram conduzidos em camundogos e humanos no início da década de 2000. Após esse período, o número de pesquisas e publicações com o mesmo propósito tem aumentado, mas com raros ou escassos estudos na espécie equina. Nesse sentindo, o objetivo desse trabalho foi avaliar o potencial in vitro da transdiferenciação neural das CTMs provenientes da MO de equinos utilizando-se dois protocolos: P1 (forksolin e ácido retinóico e P2 (2-βmecarptoetanol. Após a confirmação das linhagens mesenquimais, pela positividade para o marcador CD90 (X=97,94%, negatividade para o marcador CD34 e resposta positiva a diferenciação osteogênica, as CTMs foram submetidas a transdiferenciação neural (P1 e P2 para avaliação morfológica e expressão dos marcadores neurais GFAP e β3 tubulina por citometria de fluxo. Os resultados revelaram mudanças morfológicas em graus variados entre os protocolos testados. No protocolo 1, vinte quatro horas após a incubação com o meio de diferenciação neural, grande proporção de células (>80% apresentaram morfologia semelhante a células neurais, caracterizadas por retração do corpo celular e grande número de projeções protoplasmáticas (filopodia. Por outro lado, de forma comparativa, já nos primeiros 30 minutos após a exposição ao antioxidante β-mercaptoetanol (P2 as CTMs apresentaram rápida mudança morfológica caracterizada principalmente por retração do corpo celular e menor número de projeções protoplasmáticas. Também ficou evidenciado com o uso deste protocolo, menor aderência das células após tempo de exposição ao meio de diferenciação, quando comparado ao P1. Com relação a análise imunofenotípica foi observado uma maior (P<0,001 expressão dos marcadores GFAP e β3 tubulina ao término do P2 quando comparado ao P1. A

  12. Transplante de células-tronco hematopoéticas no diabete melito do tipo I Autologous hematopoietic stem cell transplantation in type I diabetes mellitus

    Directory of Open Access Journals (Sweden)

    Júlio C. Voltarelli

    2004-03-01

    Full Text Available Transplantes autólogos de células-tronco hematopoéticas (TACTH para doenças auto-imunes (DAÍ graves e refratárias à terapia convencional têm sido realizados desde 1996, principalmente dirigidos a doenças reumáticas e neurológicas, com resultados encorajadores. De modo geral, dois terços dos pacientes alcançam remissão duradoura da doença auto-imune, embora a morbimortalidade relacionada ao transplante ou à recidiva e progressão da DAI ainda constituam problemas significativos. Baseados nesses resultados e no efeito benéfico da imunossupressão moderada na evolução do diabete melito do tipo I (DM-I, iniciamos, em dezembro de 2003, um protocolo clínico de TACTH para esta doença, em cooperação com a Universidade Northwestern de Chicago, da Universidade de Miami e do National Institutes of Health. Pacientes com DM-I abaixo de 35 anos, diagnosticados há menos de seis semanas ou na fase assintomática ("lua-de-mel" da doença têm suas CTH mobilizadas com ciclofosfamida (2 g/m² e G-CSF, coletadas do sangue periférico e criopreservadas. Após o condicionamento com ciclofosfamida (200 mg/kg e globulina antitimocitária de coelho (4,5 mg/kg e a infusão das CTH autólogas, os pacientes são seguidos por cinco anos em relação aos aspectos clínicos, endocrinológicos e imunológicos do diabete. Este estudo clínico poderá representar uma importante contribuição científica do transplante de medula óssea brasileiro à moderna era de terapia celular de doenças inflamatórias e degenerativas.Autologous hematopoietic stem cell transplantation (AHSCT for severe and refractory autoimmune diseases has been performed since 1996 with encouraging results. In general, two thirds of the patients achieve durable remissions, although morbidity and mortality related to transplantation or to relapse and progression of autoimmune diseases are still significant. Based on those results and on beneficial effects of moderate immunosuppression

  13. Modelo experimental de bandagem ajustável do tronco pulmonar para preparo rápido do ventrículo

    Directory of Open Access Journals (Sweden)

    DIAS Carlos A.

    2000-01-01

    Full Text Available OBJETIVO: Um dispositivo de bandagem do tronco pulmonar (TP com ajuste percutâneo foi desenvolvido com o objetivo de induzir a hipertrofia rápida do ventrículo subpulmonar. MATERIAL E MÉTODOS: Consiste de um manguito de silicone insuflável percutaneamente, através de um botão de silicone auto-selante. Os corações de 7 cabritos jovens (peso médio: 8,7 kg foram submetidos à sobrecarga sistólica imposta pelo dispositivo e avaliados sob os aspectos hemodinâmicos, ecocardiográficos e morfológicos. Foram extraídas biópsias basais do miocárdio do ventrículo direito (VD para análise microscópica (perímetro e área do miócito. O dispositivo foi implantado no TP. As pressões do VD, TP e aorta foram monitorizadas. Após convalescença, foi iniciado o protocolo de insuflação do dispositivo de bandagem do TP. Foi injetada água destilada no botão auto-selante (via percutânea, até que a pressão sistólica do VD atingisse 70% da pressão sistólica do VE. As avaliações ecocardiográfica e hemodinâmica foram realizadas a cada 24 horas. A sobrecarga sistólica do VD foi mantida por um período de 96 horas, com insuflações progressivas no limite máximo tolerado, a cada 24 horas. Após esse período, os animais foram sacrificados para análise morfológica dos corações. Outros 9 cabritos (peso médio: 7,7 kg foram utilizados como grupo controle, para análise do peso do VD. RESULTADOS: Após 96 horas de sobrecarga sistólica do VD, foi observado um aumento do gradiente sistólico VD/TP de 10,1±4,3 mmHg para 60,0±11,0 mmHg e da pressão sistólica no VD de 22,4±4,1 mmHg para 71,0±10,0 mmHg (p<0,0001. O ecocardiograma revelou aumento da espessura muscular do VD, de 4,4±0,5 mm para 7,3±1,7 mm (p=0,001. Quando comparado ao grupo controle, houve um ganho de peso de 74% do VD submetido à sobrecarga sistólica (p<0,0001. À microscopia óptica, foi observado aumento de 27% no perímetro e de 69% na área dos miócitos (p=0

  14. Transplante de célula-tronco hematopoética para síndrome mielodisplásica Bone marrow transplantation in myelodysplastic syndromes

    Directory of Open Access Journals (Sweden)

    Daniel G. Tabak

    2010-05-01

    Full Text Available As síndromes mielodisplásicas (SMD constituem um grupo de doenças hematológicas caracterizadas por citopenias crônicas, associadas a uma maturação celular anormal. A melhor forma de classificação atual destas patologias é o International Prognostic Scoring System (IPSS, que se baseia no grau de citopenia, número de mieloblastos na medula óssea e alterações citogenéticas. Há quatro estágios: baixo risco, riscos intermediário-1 e 2 e alto risco. Um grupo destes pacientes pode ser curado com o transplante de células-tronco hematopoéticas (TCTH. Esta forma de tratamento pode ser considerada para pacientes com idade inferior a 60 anos, que possuam um doador familiar HLA-idêntico. A opção por esta modalidade terapêutica depende de alguns critérios, que incluem o IPSS, o risco de progressão de doença, o risco de infecção e o estado geral do paciente. O TCTH autólogo pode ser considerado em pacientes que alcancem uma remissão completa citogenética e que não disponham de doador HLAidêntico. Em pacientes não candidatos ao TCTH mieloablativo, uma possibilidade é o transplante com regimes de intensidade reduzida. Estudos recentes têm demonstrado resultados favoráveis com esta opção terapêutica, pois, apesar do alto rico de recaída, as taxas de mortalidade associada ao procedimento são menores. Os pacientes com SMD devem ser dispostos em ensaios clínicos que considerem as comorbidades, DECH e riscos de recaída.The myelodysplastic syndrome (MDS encompasses a series of hematological conditions characterized by chronic cytopenias with abnormal cellular maturation. Based on the cytopenias, number of blast cells in bone marrow and cytogenetic abnormalities, MDS may be best classified by the International Prognostic Scoring System (IPSS in four groups: low risk, intermediate 1, intermediate 2 risks and high risk. A subset of patients can be cured following allogeneic hematopoietic stem cell transplantation (SCT. This

  15. Impacto del síndrome metabólico en la resistencia a la recanalización arterial y en el pronóstico de los pacientes con oclusión aguda de la arteria cerebral media tratados con activador tisular del plasminógeno

    OpenAIRE

    Dorado Bouix, Laura

    2012-01-01

    La recanalización arterial precoz es un punto clave para alcanzar un buen pronóstico funcional tras un ictus isquémico. El síndrome metabólico (SM) podría jugar un papel en la evolución de los pacientes con ictus isquémico tratados con activador tisular del plasminógeno (tPA) por vía sistémica (a) por su asociación a un estado protrombótico que podría interferir en la recanalización arterial inducida por tPA y (b) porque varias de las alteraciones metabólicas que acompañan al SM podrían contr...

  16. Hydrostatic determinants of cerebral perfusion

    International Nuclear Information System (INIS)

    Wagner, E.M.; Traystman, R.J.

    1986-01-01

    We examined the cerebral blood flow response to alterations in perfusion pressure mediated through decreases in mean arterial pressure, increases in cerebrospinal fluid (CSF) pressure, and increases in jugular venous (JV) pressure in 42 pentobarbital anesthetized dogs. Each of these three pressures was independently controlled. Cerebral perfusion pressure was defined as mean arterial pressure minus JV or CSF pressure, depending on which was greater. Mean hemispheric blood flow was measured with the radiolabeled microsphere technique. Despite 30-mm Hg reductions in mean arterial pressure or increases in CSF or JV pressure, CBF did not change as long as the perfusion pressure remained greater than approximately 60 mm Hg. However, whenever perfusion pressure was reduced to an average of 48 mm Hg, cerebral blood flow decreased 27% to 33%. These results demonstrate the capacity of the cerebral vascular bed to respond similarly to changes in the perfusion pressure gradient obtained by decreasing mean arterial pressure, increasing JV pressure or increasing CSF pressure, and thereby support the above definition of cerebral perfusion pressure

  17. Cerebral Sinovenous Thrombosis

    Directory of Open Access Journals (Sweden)

    Rebecca Ichord

    2017-07-01

    Full Text Available Cerebral sinovenous thrombosis (CSVT is a rare but serious cerebrovascular disorder affecting children from the newborn period through childhood and adolescence. The incidence is estimated at 0.6/100,000/year, with 30–50% occurring in newborns. Causes are diverse and are highly age dependent. Acute systemic illness is the dominant risk factor among newborns. In childhood CSVT, acute infections of the head and neck such as mastoiditis are most common, followed by chronic underlying diseases such as nephrotic syndrome, cancer, and inflammatory bowel disease. Signs and symptoms are also age related. Seizures and altered mental status are the commonest manifestations in newborns. Headache, vomiting, and lethargy, sometimes with 6th nerve palsy, are the most common symptoms in children and adolescents. Recent multicenter cohort studies from North America and Europe have provided updated information on risk factors, clinical presentations, treatment practices, and outcomes. While systemic anticoagulation is the most common specific treatment used, there are wide variations and many uncertainties even among experts concerning best practice. The treatment dilemma is especially pronounced for neonatal CSVT. This is due in part to the higher prevalence of intracranial hemorrhage among newborns on the one hand, and the clear evidence that newborns suffer greater long-term neurologic morbidity on the other hand. With the advent of widespread availability and acceptance of acute endovascular therapy for arterial ischemic stroke, there is renewed interest in this therapy for children with CSVT. Limited published evidence exists regarding the benefits and risks of these invasive therapies. Therefore, the authors of current guidelines advise reserving this therapy for children with progressive and severe disease who have failed optimal medical management. As research focused on childhood cerebrovascular disease continues to grow rapidly, the future prospects

  18. La teoría del todo (2014, una mirada hacia los efectos de la Esclerosis Lateral Amiotrófica en la vida de Stephen Hawking

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    Sofía AGUIÑAGA MALANCO

    2017-06-01

    Full Text Available Stephen Hawking, autor de las teorías más fundamentales sobre el comportamiento de los agujeros negros, entreotras consideraciones sobre el tiempo y el espacio; padece de esclerosis lateral amiotrófica, la cual le fue diagnosticadadurante su último año en Oxford, tal y como se describe en la película La teoría del todo (2014 dirigida por James Marsh y producida por Anthony McCarten. La esclerosis lateral amiotrófica (ELA o enfermedad de Lou Gehrig es una alteración neurodegenerativa progresiva que ocasiona debilitamiento gradual de la musculatura voluntaria.Se caracteriza por una pérdida progresiva de la moto?neurona de la corteza motora, tronco del encéfalo y médulaespinal.

  19. O transplante de células-tronco hematopoéticas na infância: situação atual e perspectivas Hematopoietic stem cell transplantation in childhood: current status and perspectives

    Directory of Open Access Journals (Sweden)

    Adriana Seber

    2009-05-01

    Full Text Available O transplante de células-tronco hematopoéticas (TCTH é uma opção terapêutica para um grande número de crianças com doenças malignas e não malignas. O objetivo deste artigo é apresentar a situação atual dos TCTH em pediatria para o tratamento de doenças hematológicas malignas, incluindo dados de nosso país e perspectivas futuras.Hematopoietic stem cell transplantation is a treatment option for a large number of children with malignant and non-malignant diseases. The objective of this article is to present the current status of hematopoietic stem cell transplantation in the treatment of malignant hematological diseases in pediatrics, including results in Brazil, and future perspectives.

  20. Procesos de plasticidad cerebral en pacientes con daño adquirido

    OpenAIRE

    Márquez Noriego, Blanca Esther

    2016-01-01

    Los accidentes cerebrovasculares y los traumatismos craneoencefálicos son las dos patologías principales causantes de daño cerebral adquirido. Los avances médicos han permitido disminuir considerablemente la mortalidad derivada de dichas patologías. Consecuentemente, el número de personas que padecen déficits derivados de estas lesiones aumenta a nivel mundial. Estos déficits son consecuencia del daño cerebral, el cual puede afectar a varias áreas, según las características propias de la lesi...

  1. 11 Things to Know about Cerebral Palsy

    Science.gov (United States)

    ... Button Past Emails 11 Things to Know about Cerebral Palsy Language: English (US) Español (Spanish) Recommend on Facebook Tweet Share Compartir Cerebral palsy (CP) is the most common motor disability in ...

  2. Dynamic Cerebral Autoregulation after Cardiopulmonary Bypass

    DEFF Research Database (Denmark)

    Christiansen, Claus Behrend; Berg, Ronan M G; Plovsing, Ronni R

    2016-01-01

    Background Cerebral hemodynamic disturbances in the peri- or postoperative period may contribute to postoperative cognitive dysfunction (POCD) in patients undergoing coronary artery bypass grafting (CABG) with cardiopulmonary bypass (CPB). We therefore examined dynamic cerebral autoregulation (d...

  3. CORRELAÇÃO ENTRE PUBLICAÇÕES CIENTÍFICAS E PATENTES COM CÉLULAS-TRONCO PLURIPOTENTE INDUZIDAS (iPS: BASES PARA UMA PROSPECÇÃO TECNOLÓGICA

    Directory of Open Access Journals (Sweden)

    Maria Acelina Carvalho

    2014-12-01

    Full Text Available A reprogramação de células somáticas para uma célula pluripotente indiferenciada, com características de uma célula-tronco embrionária (CTE, é um dos avanços promissores no campo da biologia celular na última década. O objetivo desse trabalho foi reunir informações como base de uma prospecção tecnológica prévia sobre o tema células-tronco pluripotente induzidas (iPS e verificar se existe correlação entre o número de publicações científicas e número de patentes na referida área. Foram pesquisadas patentes depositadas no EPO, USPTO e INPI e publicações científicas na base de dados Web of Science com a finalidade de realizar a correlação entre a quantidade de publicações científicas e o número de patentes depositados por ano e por países .A Organização Mundial de Propriedade Intelectual (WO seguida dos Estados Unidos e China detém os maiores números de patentes depositadas envolvendo iPS. Observa-se que as patentes envolvendo iPS aparecem a partir de 2007 com uma única patente japonesa registrada no INPI. Os EUA lidera o número de publicações científicas sobre iPS com 1.679 publicações na base de dados Web of Science.

  4. Middle cerebral artery revascularization: anatomical studies and considerations on the anastomosis site Revascularização da artéria cerebral média: estudo anatômico e considerações sobre o local de sutura

    Directory of Open Access Journals (Sweden)

    Murilo S. Meneses

    1997-01-01

    Full Text Available In the surgical management of skull base lesions and vascular diseases such as giant aneurysms, involvement of the internal carotid artery may require the resection or the occlusion of the vessel. The anastomosis of the external carotid artery and the middle cerebral artery with venous graft may be indicated to re-establish the blood flow. To determine the best suture site in the middle cerebral artery, an anatomical study was carried out. Fourteen cerebral hemispheres were analysed after the injection of red latex into the internal carotid artery. The superior and inferior trunk of the main division of the middle cerebral artery have more than 2 mm of diameter. They are superficial allowing an anastomosis using a venous graft. The superior trunk has a disadvantage, it gives rise to branches for the precentral and post-central giri. The anastomosis with the inferior trunk presents lower risk of neurological deficit even though the angular artery originates from it.No tratamento cirúrgico das lesões da base do crânio e patologias vasculares como aneurismas gigantes, a ressecção ou oclusão da artéria carótida interna pode ser necessária. A anastomose das artérias carótida externa e cerebral média com interposição de enxerto venoso pode ser utilizada para restabelecer o fluxo sangüíneo. Para determinar o melhor local de sutura na artéria cerebral média, realizou-se um estudo anatômico. Quatorze hemisférios cerebrais foram analisados depois da injeção de látex vermelho na artéria carótida interna. Os ramos superior e inferior da divisão principal da artéria cerebral média têm mais de 2 mm de diâmetro. Eles são superficiais e permitem uma anastomose utilizando um enxerto venoso. O tronco superior tem a desvantagem de dar origem aos ramos para os giros pré e pós-centrais. A anastomose com o tronca inferior apresenta menor risco de déficit neurológico, apesar da artéria angular ter origem desse vaso.

  5. Organización celular del área 10 de la corteza orbitofrontal del ser humano

    OpenAIRE

    Hernán J. Pimienta J.; John Umbarila Prieto

    2005-01-01

    La región orbital del área 10 de la corteza cerebral del humano se relaciona con la disociación de la atención, la introspección, la monitorización individuo-ambiente y la memoria prospectiva.  Los estudios imaginológicos funcionales han identificado asimetrías en la actividad prefrontal.  Los correlatos celulares de estas asimetrías son desconocidos.

  6. Organización celular del área 10 de la corteza orbitofrontal del ser humano

    Directory of Open Access Journals (Sweden)

    Hernán J. Pimienta J.

    2005-03-01

    Full Text Available La región orbital del área 10 de la corteza cerebral del humano se relaciona con la disociación de la atención, la introspección, la monitorización individuo-ambiente y la memoria prospectiva.  Los estudios imaginológicos funcionales han identificado asimetrías en la actividad prefrontal.  Los correlatos celulares de estas asimetrías son desconocidos.

  7. Cerebral oximetry in preterm infants

    DEFF Research Database (Denmark)

    Greisen, Gorm; Andresen, Bjørn; Plomgaard, Anne Mette

    2016-01-01

    Preterm birth constitutes a major cause of death before 5 years of age and it is a major cause of neurodevelopmental impairment across the world. Preterm infants are most unstable during the transition between fetal and newborn life during the first days of life and most brain damage occurs...... in this period. The brain of the preterm infant is accessible for tissue oximetry by near-infrared spectroscopy. Cerebral oximetry has the potential to improve the long-term outcome by helping to tailor the support of respiration and circulation to the individual infant's needs, but the evidence is still lacking....... The goals for research include testing the benefit and harms of cerebral oximetry in large-scale randomized trials, improved definition of the hypoxic threshold, better understanding the effects of intensive care on cerebral oxygenation, as well as improved precision of oximeters and calibration among...

  8. NEYROPSYCHOLOGICAL CONSECUENCES OF CEREBRAL PALSY

    Directory of Open Access Journals (Sweden)

    ANA MARÍA NAVARRO MELENDRO

    2005-01-01

    Full Text Available Cerebral Palsy is defined as a movement alteration result of a non progressive damage witch is permanent in anencephalon that has not acquired its final maturation. Patients that suffer cerebral palsy present learning disabilities,that varies between being completely normal to severe as a consequence of memory, gnosis, praxis, perceptive andlanguage impairments. Nevertheless the consequences of this disease are not always predictable. This paper pretendsto make a description of the cognitive and behavioral deficits that overcomes along with the manifestation of thecerebral palsy and its possible treatment. We used a complete neuropsychological battery to evaluate a 7 years oldpatient who was diagnosed of cerebral palsy and spastic diplegia finding some cognitive impairment in fields such asmnesic, gnosic and attention processes.

  9. Natriuretic peptides and cerebral hemodynamics

    DEFF Research Database (Denmark)

    Guo, Song; Barringer, Filippa; Zois, Nora Elisabeth

    2014-01-01

    Natriuretic peptides have emerged as important diagnostic and prognostic tools for cardiovascular disease. Plasma measurement of the bioactive peptides as well as precursor-derived fragments is a sensitive tool in assessing heart failure. In heart failure, the peptides are used as treatment...... in decompensated disease. In contrast, their biological effects on the cerebral hemodynamics are poorly understood. In this mini-review, we summarize the hemodynamic effects of the natriuretic peptides with a focus on the cerebral hemodynamics. In addition, we will discuss its potential implications in diseases...... where alteration of the cerebral hemodynamics plays a role such as migraine and acute brain injury including stroke. We conclude that a possible role of the peptides is feasible as evaluated from animal and in vitro studies, but more research is needed in humans to determine the precise response...

  10. Estudio anatómico de la rama superficial del nervio radial, implicaciones quirúrgicas

    Directory of Open Access Journals (Sweden)

    Enrique Vergara Amador

    2010-07-01

    Full Text Available Antecedentes. Conocer la anatomía de la rama superficial del nervio radial, es indispensable para la adecuada práctica de cirugías que involucran la mano y la muñeca. Objetivo. Determinar las relaciones del nervio radial y sus ramas con el tubérculo de Lister, la apófisis estiloides del radio y la distribución en el dorso de la mano. Material y métodos. Se disecaron 25 piezas de cadáveres frescos. Se identificó la rama superficial del nervio radial y se midió la distancia entre la salida del nervio y la apófisis estiloides del radio. Se identificaron las ramas del nervio en el antebrazo distal y en la muñeca y se midieron respecto a la apófisis estiloides y al tubérculo de Lister. Resultados. La rama superficial del nervio radial emergió en la región dorsal y radial del tercio distal del antebrazo entre el músculo braquiradialis y el extensor carpis radialis longus, a una distancia de 8,45 cm proximal a la apófisis estiloides. Su primera rama de división discurrió palmar a la apófisis estiloides radial a una distancia promedio de 0,74 cm respecto a la misma. El tronco principal se dividió en varias ramas terminales así: proximal a la apófisis estiloides del radio (28%, a nivel de la misma (12% y distal (60%. El patrón de distribución de las ramas nerviosas en la base de los dedos más frecuente fue el del primero, segundo y el lado radial del tercer dedo (56%. Discusión. Este estudio mostró la gran variabilidad de la rama superficial del nervio radial en el dorso de la mano y la alta probabilidad de daño del mismo durante los procedimientos abiertos, artroscópicos o procedimientos percutáneos en la muñeca.

  11. Cerebral edema associated with acute hepatic failure.

    OpenAIRE

    Fujiwara, Masachika; Watanabe, Akiharu; Yamauchi, Yasuhiko; Hashimoto, Makoto; Nakatsukasa, Harushige; Kobayashi, Michio; Higashi, Toshihiro; Nagashima, Hideo

    1985-01-01

    The clinicopathological findings of cerebral edema were investigated in patients with acute hepatic failure autopsied at Okayama University Hospital between 1970 and 1980 retrospectively. Nine (64%) of 14 hepatic failure cases were found to have cerebral edema during a post-mortem examination of the brain. Clinical features of the patients with cerebral edema were not significantly different from those of the patients without cerebral edema. However, general convulsions were observed more fre...

  12. Cerebral MR imaging in vasculitis

    International Nuclear Information System (INIS)

    Ott, D.; Geissler, A.; Peter, H.H.

    1990-01-01

    This paper evaluates the diagnostic sensitivity and specificity of MR imaging for the detection of cerebral involvement in vasculitis. Seventy-six patient with proved systematic vasculitis and two with isolated cerebral vasculitis were examined. Half of them had central nervous system symptoms. T2-weighted sequences were performed at 2 T in most cases. All but two symptomatic and one-third of the asymptomatic patients showed pathologic changes in the white matter. The distribution and shape of lesions depend on the caliber of the involved vessel. In small-vessel vasculitis, the distribution was mostly subcortical, the average size was 0.5--10 mm, and lesions were predominantly round

  13. Features to validate cerebral toxoplasmosis

    Directory of Open Access Journals (Sweden)

    Carolina da Cunha Correia

    2013-06-01

    Full Text Available Introduction Neurotoxoplasmosis (NT sometimes manifests unusual characteristics. Methods We analyzed 85 patients with NT and AIDS according to clinical, cerebrospinal fluid, cranial magnetic resonance, and polymerase chain reaction (PCR characteristics. Results In 8.5%, focal neurological deficits were absent and 16.4% had single cerebral lesions. Increased sensitivity of PCR for Toxoplasma gondii DNA in the central nervous system was associated with pleocytosis and presence of >4 encephalic lesions. Conclusions Patients with NT may present without focal neurological deficit and NT may occur with presence of a single cerebral lesion. Greater numbers of lesions and greater cellularity in cerebrospinal fluid improve the sensitivity of PCR to T gondii.

  14. Recent Experiences with Severe and Cerebral Malaria

    African Journals Online (AJOL)

    1974-06-29

    Jun 29, 1974 ... Malaria admissions. Cerebral malaria ... Cerebral signs. Haemoglobin below 10 g/100 ml (not all tested). Enlarged tender liver or jaundice, or both ... articl~ by H. Smitskamp and F. H. Wolthuis entitled 'New concepts in treatment of malaria with malignant tertian cerebral involvement' which appeared in the ...

  15. Cerebral vasculitis associated with cocaine abuse

    International Nuclear Information System (INIS)

    Kaye, B.R.; Fainstat, M.

    1987-01-01

    A case of cerebral vasculitis in a previously healthy 22-year-old man with a history of cocaine abuse is described. Cerebral angiograms showed evidence of vasculitis. A search for possible causes other than cocaine produced no results. The authors include cocaine with methamphetamines, heroin, and ephedrine as illicit drugs that can cause cerebral vasculitis

  16. Neuroevolutional Approach to Cerebral Palsy and Speech.

    Science.gov (United States)

    Mysak, Edward D.

    Intended for cerebral palsy specialists, the book emphasizes the contribution that a neuroevolutional approach to therapy can make to habilitation goals of the child with cerebral palsy and applies the basic principles of the Bobath approach to therapy. The first section discusses cerebral palsy as a reflection of disturbed neuro-ontogenisis and…

  17. Cerebral toksoplasmose primaert diagnosticeret som tumor

    DEFF Research Database (Denmark)

    Cortsen, M E; Skøt, J; Skriver, E B

    1992-01-01

    Three cases of cerebral toxoplasmosis as the presenting manifestation of AIDS are reported. The initial diagnoses were brain tumors because of the cerebral mass lesions which resembled glioblastoma. In the light of the increasing occurrence of AIDS, attention is drawn to cerebral toxoplasmosis...

  18. Fenestration of the anterior cerebral artery

    International Nuclear Information System (INIS)

    Ito, J.; Washiyama, K.; Hong Kim, C.; Ibuchi, Y.

    1981-01-01

    Three cases of angiographically demonstrated fenestration of the anterior cerebral artery are reported. Fenestration occurred at the medial half of the horizontal segment of the anterior cerebral artery in all cases. Its embryology and clinical significance are briefly discussed, and the anatomical and radiological literature on fenestration of the anterior cerebral artery is reviewed. (orig.)

  19. Cirugía de revascularización miocárdica versus stent farmacoactivos en pacientes con enfermedad de tronco común izquierdo: una revisión sistemática de ensayos clínicos aleatorizados y de metaanálisis de ensayos clínicos aleatorizados

    Directory of Open Access Journals (Sweden)

    Stefano Urso

    2018-03-01

    Full Text Available Resumen: Objetivo: El objetivo de la presente revisión sistemática es analizar en la literatura los resultados clínicos de cirugía de revascularización coronaria versus la intervención coronaria percutánea con stent farmacoactivos en el tratamiento de la enfermedad del tronco común izquierdo. Métodos: Se realizó una búsqueda bibliográfica mediante las bases de datos de Pubmed, Google Scholar, Medline, Embase y Cochrane, restringiendo dicha búsqueda a ensayos clínicos aleatorizados o metaanálisis realizados sobre ensayos clínicos aleatorizados, sin restricción de año de publicación ni de idioma. Resultados: Ochenta y dos artículos fueron encontrados usando la metodología de búsqueda descrita. De estos, fueron seleccionados 7 artículos procedentes de 5 ensayos de no inferioridad (SYNTAX, PRECOMBAT, estudio de Boudriot et al., NOBLE y EXCEL y 7 metaanálisis. Los presentes ensayos han comparado stent farmacoactivos de primera generación (SYNTAX: stent con paclitaxel; ensayo de Boudriot et al. y PRECOMBAT: stent con sirolimus y stents farmacoactivos de segunda generación (NOBLE: stent con biolimus; EXCEL: stent con everolimus con cirugía.Con referencia al procedimiento de revascularización coronaria, la utilización de la doble arteria mamaria interna osciló entre el 7,4 y el 54,4%. Todos los ensayos clínicos incluidos en esta revisión reportaron una tasa estadísticamente menor de revascularización repetida en la población quirúrgica. De acuerdo con la revisión de metaanálisis, el riesgo, expresado como razón de probabilidades, de requerir un nuevo procedimiento de revascularización miocárdica por la población percutánea en comparación con el de la población quirúrgica osciló entre 1,68 y 2,21. Conclusiones: Independientemente del tipo de stent farmacoactivo utilizado en los procedimientos percutáneos y a pesar de la baja tasa de utilización de la doble arteria mamaria interna en el grupo quir

  20. What is cerebral small vessel disease?

    International Nuclear Information System (INIS)

    Onodera, Osamu

    2011-01-01

    An accumulating amount of evidence suggests that the white matter hyperintensities on T 2 weighted brain magnetic resonance imaging predict an increased risk of dementia and gait disturbance. This state has been proposed as cerebral small vessel disease, including leukoaraiosis, Binswanger's disease, lacunar stroke and cerebral microbleeds. However, the concept of cerebral small vessel disease is still obscure. To understand the cerebral small vessel disease, the precise structure and function of cerebral small vessels must be clarified. Cerebral small vessels include several different arteries which have different anatomical structures and functions. Important functions of the cerebral small vessels are blood-brain barrier and perivasucular drainage of interstitial fluid from the brain parenchyma. Cerebral capillaries and glial endfeet, take an important role for these functions. However, the previous pathological investigations on cerebral small vessels have focused on larger arteries than capillaries. Therefore little is known about the pathology of capillaries in small vessel disease. The recent discoveries of genes which cause the cerebral small vessel disease indicate that the cerebral small vessel diseases are caused by a distinct molecular mechanism. One of the pathological findings in hereditary cerebral small vessel disease is the loss of smooth muscle cells, which is an also well-recognized finding in sporadic cerebral small vessel disease. Since pericytes have similar character with the smooth muscle cells, the pericytes should be investigated in these disorders. In addition, the loss of smooth muscle cells may result in dysfunction of drainage of interstitial fluid from capillaries. The precise correlation between the loss of smooth muscle cells and white matter disease is still unknown. However, the function that is specific to cerebral small vessel may be associated with the pathogenesis of cerebral small vessel disease. (author)

  1. Hiperoxia por dos horas produce daño morfológico cerebral luego de asfixia neonatal experimental

    Directory of Open Access Journals (Sweden)

    Melva Benavides

    2013-10-01

    Full Text Available Objetivos: Determinar el efecto de una exposición de dos horas de hiperoxia al 21%, 40% y 100% sobre la morfología cerebral, en un modelo experimental de asfixia neonatal. Diseño: Estudio experimental. Institución: Instituto Nacional de Salud del Niño, Lima, Perú. Material biológico: Ratas albinas Holtzmann. Intervenciones: Ciento veinte ratas albinas Holtzmann de una semana de nacidas (a excepción del grupo control fueron sometidas a asfixia experimental por ligadura de la arteria carótida izquierda y luego expuestas a hipoxia (oxígeno al 8%. Después fueron asignadas aleatoriamente a uno de los siguientes grupos: exposición por dos horas a O2 al 100%, a O2 al 40%, a O2 al 21% y un grupo control (no expuesto a asfixia experimental. El daño cerebral fue evaluado mediante la medición del peso cerebral y el porcentaje del área cerebral con daño microscópico. Principales medidas de resultados: Daño cerebral. Resultados: El peso cerebral promedio fue menor en los animales de los grupos sometidos a hiperoxia experimental (ANOVA; p<0,001. Se presentó daño cerebral microscópico con mayor frecuencia en el grupo sometido a hipoxia experimental que recibió O2 100% por dos horas y con menor frecuencia en el que recibió O2 al 40% (60% versus 43,3%, diferencia que fue estadísticamente significativa (prueba χ²; p<0,001. El grupo sometido a hipoxia experimental que recibió O2 100% tuvo un mayor porcentaje promedio de área cerebral con daño microscópico (18,3%, en comparación con los otros grupos de hipoxia experimental, aunque la diferencia no fue estadísticamente significativa (ANOVA; p=0,123. Conclusiones: La hiperoxia al 100% por dos horas se asoció con menor peso cerebral y mayor daño cerebral en animales de experimentación sometidos a asfixia neonatal experimental.

  2. Oculoauriculovertebral spectrum and cerebral anomalies

    NARCIS (Netherlands)

    Schrander-Stumpel, C. T.; de Die-Smulders, C. E.; Hennekam, R. C.; Fryns, J. P.; Bouckaert, P. X.; Brouwer, O. F.; da Costa, J. J.; Lommen, E. J.; Maaswinkel-Mooy, P. D.

    1992-01-01

    We report on three Dutch children with a clinical diagnosis of oculoauriculovertebral spectrum (OAVS) and hydrocephalus. The clinical features are compared to 15 published cases of OAVS and hydrocephalus. Several other cerebral abnormalities were present in the whole group. About half of the cases

  3. CT of cerebral hydatid disease

    Energy Technology Data Exchange (ETDEWEB)

    Rudwan, M.A.; Khaffaji, S.

    1988-12-01

    Six cases of cerebral hydatid disease (CHD) were seen in Kuwait over a period of 8 years. The typical CT appearance of a large well-defined spherical nonenhanced unilocular cyst was seen in four cases. Two unusual but characteristic types of calcification were seen, one in each of the remaining two cases.

  4. CT of cerebral hydatid disease

    International Nuclear Information System (INIS)

    Rudwan, M.A.; Khaffaji, S.

    1988-01-01

    Six cases of cerebral hydatid disease (CHD) were seen in Kuwait over a period of 8 years. The typical CT appearance of a large well-defined spherical nonenhanced unilocular cyst was seen in four cases. Two unusual but characteristic types of calcification were seen, one in each of the remaining two cases. (orig.)

  5. MR imaging of cerebral palsy

    International Nuclear Information System (INIS)

    Saginoya, Toshiyuki; Yamaguchi, Keiichiro; Kuniyoshi, Kazuhide

    1996-01-01

    We evaluated 35 patients with cerebral palsy on the basis of MR imaging findings in the brain. The types of palsy were spastic quadriplegia (n=11), spastic diplegia (n=9), spastic hemiplegia (n=2), double hemiplegia (n=1), athetosis (n=10) and mixed (n=2). Of all patients, 28 (80%) generated abnormal findings. In spastic quadriplegia, although eight cases revealed severe brain damage, two cases showed no abnormal findings in the brain. One of the three had cervical cord compression caused by atlanto-axial subluxation. In spastic diplegia, the findings were divided according to whether the patient was born at term or preterm. If the patient had been born prematurely, the findings showed periventricular leukomalacia and abnormally high intensity in the posterior limbs of the internal capsule on T2-weighted images. MR imaging in spastic hemiplegia revealed cerebral infarction. In the athetoid type, half of all cases showed either no abnormal findings or slight widening of the lateral ventricle. Three cases showed abnormal signals of the basal ganglia. The reason why athetoid-type palsy did not show severe abnormality is unknown. We believe that MR imaging is a useful diagnostic modality to detect damage in the brain in cerebral palsy and plays an important role in the differentiation of cerebral palsy from the spastic palsy disease. (author)

  6. MR imaging of cerebral palsy

    Energy Technology Data Exchange (ETDEWEB)

    Saginoya, Toshiyuki [Urasoe General Hospital, Okinawa (Japan); Yamaguchi, Keiichiro; Kuniyoshi, Kazuhide [and others

    1996-06-01

    We evaluated 35 patients with cerebral palsy on the basis of MR imaging findings in the brain. The types of palsy were spastic quadriplegia (n=11), spastic diplegia (n=9), spastic hemiplegia (n=2), double hemiplegia (n=1), athetosis (n=10) and mixed (n=2). Of all patients, 28 (80%) generated abnormal findings. In spastic quadriplegia, although eight cases revealed severe brain damage, two cases showed no abnormal findings in the brain. One of the three had cervical cord compression caused by atlanto-axial subluxation. In spastic diplegia, the findings were divided according to whether the patient was born at term or preterm. If the patient had been born prematurely, the findings showed periventricular leukomalacia and abnormally high intensity in the posterior limbs of the internal capsule on T2-weighted images. MR imaging in spastic hemiplegia revealed cerebral infarction. In the athetoid type, half of all cases showed either no abnormal findings or slight widening of the lateral ventricle. Three cases showed abnormal signals of the basal ganglia. The reason why athetoid-type palsy did not show severe abnormality is unknown. We believe that MR imaging is a useful diagnostic modality to detect damage in the brain in cerebral palsy and plays an important role in the differentiation of cerebral palsy from the spastic palsy disease. (author)

  7. Cerebral gigantism with West syndrome.

    Science.gov (United States)

    Ray, Munni; Malhi, P; Bhalla, A K; Singhi, P D

    2003-07-01

    A case of cerebral gigantism (Sotos syndrome) with West syndrome in a one-year-old male child is reported. The case had a large stature, typical facies and neurodevelopmental delay along with infantile spasms, which were refractory to treatment with valproate and clonazepam.

  8. Cerebral imaging revealing Alzheimer's disease

    International Nuclear Information System (INIS)

    2011-01-01

    Cerebral imaging is the only non-invasive means of examining the brain and is essential in studying Alzheimer's disease. As a tool for early diagnosis, evaluation and treatment monitoring, this technology is at the heart of the research being done to further improve its reliability and sensitivity. (authors)

  9. Ocular defects in cerebral palsy

    Directory of Open Access Journals (Sweden)

    Katoch Sabita

    2007-01-01

    Full Text Available There is a high prevalence of ocular defects in children with developmental disabilities. This study evaluated visual disability in a group of 200 cerebral palsy (CP patients and found that 68% of the children had significant visual morbidity. These findings emphasize the need for an early ocular examination in patients with CP.

  10. Computerized tomography of cerebral infarction

    Energy Technology Data Exchange (ETDEWEB)

    Yamashita, K; Mihara, T; Kobayashi, E; Yamamoto, K; Kusumoto, K [Kagoshima Univ. (Japan). Faculty of Medicine

    1978-12-01

    In 120 cases of patients with cerebral infarction, the affected areas in the CT images were analyzed with special reference to the site, the size, and the extension. Moreover, on 39 scans of 34 cases examined with 8 weeks after the onset of strokes, the CT images were analyzed from the viewpoint of the presence of a mass effect, edema, contrast enhancement, and the accompanying hemorrhage. From these investigations, the authors have obtained the following results; 1) The greatest incidence of infarcts was in the area supplied by the middle cerebral artery (57% of the cases), and, among those, the area of the lenticulostriate arteries showed the highest incidence (53%). Even in the posterior fossa, infarcts were found in 6% of the cases. These findings are coincident with those in autopsied cases. 2) Putaminal infarcts and infarctions occurring in the area supplied by the calcarine artery seemed to be uniformity of the arcuate pattern. 3) Most of the infarcts in the perfusion area of the anterior cerebral artery and the basal ganglia were found to be small and multifocal; they were thought to correspond with water-shed and/or lacunar infarcts. 4) In approximately 25% of the cases examined within 8 weeks after the onset of strokes, the CT images revealed mass effects which had never been observed after more than 3 weeks. In conclusion, the presence of a mass effect, accompanying hemorrhage, and contrast enhancement detected by CT should lead us to reconsider the conventional management of cerebral infarction.

  11. Potencial del Agua del suelo

    Directory of Open Access Journals (Sweden)

    Bustamante Heliodoro

    1986-12-01

    Full Text Available La energía potencial del agua presenta diferencias de un punto del suelo a otro; esas diferencias son las que originan el movimiento del agua de acuerdo a la tendencia universal de la materia en el sentido de moverse de donde la energía potencial es mayor a donde dicha energía es menor. En el suelo el agua en consecuencia se mueve hacia donde su energía decrece hasta lograr su estado de equilibrio. Se desprende entonces que la cantidad de energía potencial absoluta contenida en el agua, no es importante por sí misma, sino por su relación con la energía en diferentes lugares dentro del suelo. El concepto Potencial de agua del suelo es un criterio para esta energía.

  12. Cerebral edema in drug addicts

    Directory of Open Access Journals (Sweden)

    Daruši Dragana J.

    2014-01-01

    Full Text Available Background/Aim. The effect of drugs leaves permanent consequences on the brain, organic in type, followed by numerous manifestations, and it significantly affects the development of mental dysfunctions. The clinicians are often given a task to estimate a patient’s personality during treatment or during experts estimate of a drug addict. The aim of this research was to determine the differences, if any, in characteristics of addicts experience and personality traits in drug addicts with or without cerebral edema. Methods. The research was conducted on a sample of 252 male drug addicts, the average age of 23.3 (SD = 4.3 years. Cerebral edema was confirmed on magnetic resonance (MR images of the brain performed during the treatment of the addicts. The participants were tested by the psychologists using Minnesota Multiphasic Personality Inventory (MMPI-201 test, and the data were processed using canonical discriminate analysis within the SPSS program. The dependent variable in the study was cerebral edema. A block of independent variables, designed for the requirements of this study, consisted of two subgroups. The first one consisted of 12 variables describing the relevant characteristics of drug abuse. The second subgroup consisted of 8 psychopathological tendencies in the personality defined by the mentioned test. Results. Cerebral edema was confirmed in 52 (20.63% of the drug addicts. The differences between the groups of drug addicts with and without cerebral edema were determined in the following: the time span of taking drugs (0.301, use of alcohol parallel with drugs (0.466, and treatment for addiction (0.603. In the drug addicts with a cerebral edema, MMPI-201 confirmed the increase in the scales for hypochondria, psychopathic deviations and psychastenia, and the decrease in the scales for schizophrenia and depression. Conclusion. Our study confirmed a possible connection between cerebral edema and personality traits in a number of the

  13. MR angiography of cerebral aneurysms

    International Nuclear Information System (INIS)

    Miki, Hitoshi; Tanada, Shuji; Sakaki, Saburo; Hamamoto, Ken; Sadamoto, Kazuhiko.

    1992-01-01

    Time-of-flight (TOF) MR angiography (MRA) and phase-contrast (PC) MRA are examined clinically for evaluating cerebral aneurysms. In the morphological diagnosis of cerebral aneurysms, three-dimensional (3D) MRA is superior to two-dimensional (2D) MRA because 3D MRA has a higher S/N ratio and a higher spatial resolution. However, it is difficult to decide which, 3D TOF MRA or 3D PC MRA, is superior, for both methods have many scan parameters. In our study, 3D PC MRA was performed using two methods; one had the same acquisition time as 3D TOF MRA, while the other had the same spatial resolution as 3D TOF MRA. The detectability of aneurysms by each MRA method was evaluated in comparison with 3D TOF MRA. In fifteen patients (6 males and 9 females), a total of 16 cerebral aneurysms (3 ruptured and 13 unruptured) were studied. The lesion sizes ranged from 2.5 to 18 mm. All the 16 lesions were examined by means of 3D TOF MRA, 3D PC MRA, and conventional angiography. MR imaging was performed with a 1.5 tesla MRI system (Signa). All of the 16 cerebral aneurysms were detected by 3D TOF MRA, while only 11 of them were detected by 3D PC MRA. When 3D PC MRA was performed with the same acquisition time as 3D TOF MRA, 3D PC MRA was superior in showing one of the 7 aneurysms. When 3D PC MRA was performed with same spatial resolution as 3D TOF MRA, 3D PC MRA was superior in showing two of the 10 aneurysms. 3D TOF MRA was superior to 3D PC MRA in the detection of cerebral aneurysms because of the long acquisition times and the different flow velocity, which induced different signal intensities between the aneurysms and parent arteries in 3D PC MRA. 3D PC MRA was superior to 3D TOF MRA in patients with large thrombotic aneurysms of the internal carotid artery. We consider that 3D TOF MRA should be the first choice for screening and following-up cerebral aneurysms. 3D PC MRA should then be performed for large cerebral aneurysms in addition to 3D TOF MRA. (author)

  14. [Advances in genetic research of cerebral palsy].

    Science.gov (United States)

    Wang, Fang-Fang; Luo, Rong; Qu, Yi; Mu, De-Zhi

    2017-09-01

    Cerebral palsy is a group of syndromes caused by non-progressive brain injury in the fetus or infant and can cause disabilities in childhood. Etiology of cerebral palsy has always been a hot topic for clinical scientists. More and more studies have shown that genetic factors are closely associated with the development of cerebral palsy. With the development and application of various molecular and biological techniques such as chromosome microarray analysis, genome-wide association study, and whole exome sequencing, new achievements have been made in the genetic research of cerebral palsy. Chromosome abnormalities, copy number variations, susceptibility genes, and single gene mutation associated with the development of cerebral palsy have been identified, which provides new opportunities for the research on the pathogenesis of cerebral palsy. This article reviews the advances in the genetic research on cerebral palsy in recent years.

  15. NMR imaging of cerebral infarction

    International Nuclear Information System (INIS)

    Takusagawa, Yoshihiko; Yamaoka, Naoki; Doi, Kazuaki; Okada, Keisei

    1987-01-01

    One hundred and five patients with cerebral infarction were studied by nuclear magnetic resonance (NMR) CT (resistive type of magnet with strength of 0.1 tesla) and X-ray CT. Pulse sequences used saturation recovery (Tr = 600 mSec), Inversion recovery (Tr = 500 mSec, Td = 300 mSec) and spin echo (Tr = 1500 mSec, Te = 40, 80, 120, 160 mSec). Fifteen cases were examined by NMR-CT within 24 hours from onset. Proton NMR imaging could not detect cerebral ischemia as early as 2 hours after onset, but except could detect the lesions in Se image the area of cerebral infarct 3 hours after onset. After 5 hours from onset image changes in SE were evident and corresponded to the area of cerebral infarct, but image changes in IR could not fully delineate the infarcted area. NMR images of 41 year-old woman with cerebral embolism by MCA trunck occlusion associated with mitral stenosis were presented, and NMR-CT was examined 10 hours, 9th and 43th days after episode of MCA occlusion. Sixty patents (64 times) with lacunar infarction were studied by NMR-CT and X-ray CT. The inversion recovery images were used mainly for detection of lesions and comparison with X-ray CT. In 160 lesions which were detected by NMR-CT or X-ray CT, could 156 lesions be detected by NMR-CT and 78 lesions by X-ray CT. Inversion recovery images were more useful for detection of lacunes than X-ray CT. Calculated T1 and T2 values prolonged with time course from onset. (author)

  16. Genetic modification of cerebral arterial wall: implications for prevention and treatment of cerebral vasospasm.

    Science.gov (United States)

    Vijay, Anantha; Santhanam, R; Katusic, Zvonimir S

    2006-10-01

    Genetic modification of cerebral vessels represents a promising and novel approach for prevention and/or treatment of various cerebral vascular disorders, including cerebral vasospasm. In this review, we focus on the current understanding of the use of gene transfer to the cerebral arteries for prevention and/or treatment of cerebral vasospasm following subarachnoid hemorrhage (SAH). We also discuss the recent developments in vascular therapeutics, involving the autologous use of progenitor cells for repair of damaged vessels, as well as a cell-based gene delivery approach for the prevention and treatment of cerebral vasospasm.

  17. Cerebral blood flow and cerebral oxygen metabolism in thalamic hemorrhage

    International Nuclear Information System (INIS)

    Yasui, Nobuyuki; Asakura, Ken

    1987-01-01

    Cerebral blood flow (CBF), cerebral oxygen consumption (CMRO 2 ), oxygen extraction fraction (OEF) and cerebral blood volume (CBV) were studied in 20 cases of thalamic hemorrhage using positron CT and 15 O labeled gas steady-state inhalation method. CBF reduction was limited around the thalamus in the small sized hematoma. CBF were significantly diminished in the mean cortical, parietal, temporal, basal ganglia and thalamic area ipsilateral and cerebellar cortex contralateral to the medium sized hematoma. There was bilateral and diffuse CBF reduction in the large sized hematoma which was caused by increased intracranial pressure. CMRO 2 value were similary changed as CBF. OEF change showed within normal limit. Diffuse CBV reduction was observed in the large sized hematoma. This reduction was the result of decreased vascular bed caused by mass effect of the hematoma and hydrocephalus. Effect of surgical treatment such as ventricular drainage and hematoma evacuation were also discussed in correlation to CBF in some case using positron and single photon ECT. (author)

  18. Cambios en el tono muscular en dos niños con parálisis cerebral espástica mediante la hipoterapia: reporte de casos

    OpenAIRE

    Rodríguez Laiseca, Yasmín Andrea; Lerma Castaño, Piedad Rocío

    2015-01-01

    Introducción: Estudios previos han demostrado que la hipoterapia como terapia complementaria mejora la función motora gruesa en niños con parálisis cerebral. Sin embargo la evidencia no es concluyente. Objetivo: Determinar los cambios en el tono muscular de dos pacientes con parálisis cerebral tipo cuadriparesia espástica mediante la hipoterapia. Descripción del caso: El estudio se llevó a cabo con dos sujetos de género masculino de dos años de edad, con diagnóstico de parálisis cerebral tipo...

  19. Clinical application of cerebral dynamic perfusion studies

    International Nuclear Information System (INIS)

    DeLand, F.H.

    1975-01-01

    Radionuclide cerebral perfusion studies are assuming a far greater importance in the detection and differential diagnosis of cerebral lesions. Perfusion studies not only contribute to the differential diagnosis of lesions but in certain cases are the preferred methods by which more accurate clinical interpretations can be made. The characteristic blood flow of arterio-venous malformations readily differentiates this lesion from neoplasms. The decreased perfusion or absent perfusion observed in cerebral infarctions is diagnostic without concurrent evidence from static images. Changes in rates and direction of blood flow contribute fundamental information to the status of stenosis and vascular occlusion and, in addition, offer valuable information on the competency and routes of collateral circulation. The degree of cerebral perfusion after cerebral vascular accidents appears to be directly related to patient recovery, particularly muscular function. Cerebral perfusion adds a new parameter in the diagnosis of subdural haematomas and concussion and in the differentiation of obscuring radioactivity from superficial trauma. Although pictorial displays of perfusion blood flow will offer information in most cerebral vascular problems, the addition of computer analysis better defines temporal relationships of regional blood flow, quantitative changes in flow and the detection of the more subtle increases or decreases in cerebral blood flow. The status of radionuclide cerebral perfusion studies has taken on an importance making it the primary modality for the diagnosis of cerebral lesions. (author)

  20. Impacto do diagnóstico de paralisia cerebral para a família

    Directory of Open Access Journals (Sweden)

    Meryeli Santos de Araújo Dantas

    2010-01-01

    Full Text Available Investigación cualitativa, exploratorio-descriptiva, con el objetivo de comprender la percepción de la familia acerca del impacto del diagnóstico de parálisis cerebral de un hijo e identificar estrategias para hacer frete a la situación. Los datos fueron recolectados en una Clínica Escuela de Fisioterapia de una Universidad en João Pessoa, Paraíba, Brasil, con siete familias de niños con parálisis cerebral, de marzo a abril de 2009, mediante entrevistas semiestructuradas. El análisis siguió los principios de la interpretación temática. Los resultados mostraron que el impacto de ese diagnóstico es un momento difícil y genera sentimientos de culpa en los padres. La familia siente miedo ante el desarrollo motor del hijo y se verifican cambios en la vida cotidiana. La fe y el amor al hijo ejercen influencia sobre la forma como tratan de adaptarse a la nueva situación. La familia necesita de una red de apoyo y de atención especial de los profesionales del área de la salud, que deben ser sensibles para promover espacios de escucha atenta, minimizando el impacto del diagnóstico y contribuyendo para hacer frete a la situación.

  1. Isolamento, caracterização e diferenciação de células-tronco mesenquimais do líquido amniótico equino obtido em diferentes idades gestacionais

    Directory of Open Access Journals (Sweden)

    Bruna De Vita

    2013-04-01

    Full Text Available O interesse nas pesquisas com células-tronco derivadas de anexos fetais de diversas espécies cresceu exponencialmente nas últimas décadas em virtude de serem fontes de células-tronco adultas com potencial de diferenciação em diversas linhagens celulares que apresentam pouca ou nenhuma imunogenicidade, apresentando-se assim como alternativa de grande importância para a formação de bancos celulares. Apesar do crescente interesse, os estudos para espécie equina ainda são escassos. O objetivo deste trabalho foi isolar, caracterizar e diferenciar células-tronco mesenquimais (CTMs derivadas do líquido amniótico equino obtidas do terço inicial, médio e final da gestação (LA-CTMs, comparando suas características. Foram colhidas 23 amostras de líquido amniótico as quais foram submetidas às análises morfológica, imunocitoquímica, imunofenotípica por citometria de fluxo e às diferenciações osteogênica, adipogênica e condrogênica in vitro. Todas as amostras demonstraram adesão ao plástico e morfologia fibroblastóide. No ensaio imunocitoquímico as células de todos os grupos foram imunomarcadas para CD44, PCNA e vimentina com ausência de marcação para citoqueratina e Oct-4. Na citometria de fluxo observou-se a expressão de CD44 e CD90 e ausência de expressão de CD34, sendo que os marcadores CD44 e CD90 mostraram padrão de expressão decrescente em relação ao desenvolvimento gestacional. As amostras obtidas de todas as fases da gestação foram capazes de diferenciação nas linhagens osteogênica, condrogênica e adipogênica. Portanto, as células obtidas do líquido amniótico apresentaram características morfológicas, imunofenotípicas e potencial de diferenciação típicos das CTMs, demonstrando que a colheita pode ser realizada em qualquer fase gestacional. No entanto, mais pesquisas devem ser realizadas principalmente quanto à expressão de marcadores de pluripotencialidade (como o Oct-4 e ao seu

  2. MICROANATOMÍA QUIRÚRGICA DEL SENO CAVERNOSO: SEGUNDA PARTE - UN NUEVO REPARO PARA ACCEDER AL CONTENIDO DEL SENO

    Directory of Open Access Journals (Sweden)

    Juan Armando Mejía C.

    2010-06-01

    Full Text Available

    Resumen

    Objetivo: Hallar reparos anatómicos que permitan el abordaje seguro al seno cavernoso, utilizando medidas cronométricas para la conservación de estructuras vasculonerviosas.

    Métodos: Se disecaron 25 especímenes frescos obtenidos del Instituto de Medicina Legal y ciencias forenses a través de un abordaje extradural y la medición con microcalibrador L& W tools desde la apófisis clinoide anterior y posterior hasta las estructuras neurovasculares de importancia. Se presentan los resultados de las mediciones y se hace un análisis de sus resultados donde se especifica la longitud de cada una de las aristas de los triángulos de dicha región.

    Resultados: Se encuentra que a 5 milímetros de la punta del apófisis clinoide anterior medidos hacia abajo en una línea imaginaria perpendicular al piso de la fosa media en 21 especímenes se accedió al área del triangulo de Parkinson es decir entre el IV par y el oftálmico de Willis, pudiendo fácilmente encontrar el tronco meningohipofisiario, la porción transversa de la carótida interna intracavernosa y el segmento cavernoso del motor ocular externo; solo en cuatro piezas se llego al triangulo superior (cuya área es menor que la del triangulo de Parkinson y a través de este no fue fácil evidenciar ni el tronco meningohipofisiario ni el sexto par.

    Conclusiones: Debido al mayor área del triángulo de Parkinson (dada por su arista posterior más larga el abordaje a dicho triángulo podría ser una vía útil para la búsqueda de patologías asociadas con las estructuras neurovasculares que a través de dicho triangulo se pueden visualizar (aneurismas del tronco meningohipofisiario, aneurismas saculares del segmento transverso de la carótida interna intracavernosa y/o neurinomas del VI par intracavernoso; y se en cuentra a 5 milímetros desde la punta de la apófisis clinoide anterior medidos hacia abajo en una línea imaginaria

  3. del alcoholismo

    Directory of Open Access Journals (Sweden)

    Rodrigo Arias Duque

    2005-01-01

    Full Text Available Desde el punto de vista farmacológico, es importante comprender qué es el alcohol y cómo actúa en el organismo. No existe una causa simple, sino una interacción complicada de factores neuroquímicos, fisiológicos, psicológicos y sociales que originan y desarrollan esta grave enfermedad fármaco-dependiente. La acción psicofisiológica y farmacodinámica del alcohol es fundamentalmente depresiva, por la reducción de la transmisión sináptica en el sistema nervioso humano. Es un hecho conocido que el consumo excesivo de alcohol causa una disfunción aguda y crónica del cerebro, produciendo trastornos en el sistema nervioso central, presentando alteraciones en la memoria y en las funciones intelectuales como cálculo, comprensión y aprendizaje. A nivel hepático tiene lugar, en su mayoría, el metabolismo del alcohol, produciéndose un hígado graso alcohólico, aumentando el tamaño, terminando en necrosis e inflamación grave del hígado; esto se llama hepatitis alcohólica, y si se sigue consumiendo alcohol se desarrollará la cirrosis. El alcohol también ha estado relacionado con alteraciones del miocardio; se ha constatado en animales de experimentación sanos que tanto la velocidad de contracción del músculo cardiaco y su máxima tensión disminuyen en presencia del alcohol, como consecuencia, la fuerza de cada contracción y el aumento de presión en el ventrículo izquierdo son menores, perdiendo eficacia el corazón como bomba.

  4. Animal models of cerebral ischemia

    Science.gov (United States)

    Khodanovich, M. Yu.; Kisel, A. A.

    2015-11-01

    Cerebral ischemia remains one of the most frequent causes of death and disability worldwide. Animal models are necessary to understand complex molecular mechanisms of brain damage as well as for the development of new therapies for stroke. This review considers a certain range of animal models of cerebral ischemia, including several types of focal and global ischemia. Since animal models vary in specificity for the human disease which they reproduce, the complexity of surgery, infarct size, reliability of reproduction for statistical analysis, and adequate models need to be chosen according to the aim of a study. The reproduction of a particular animal model needs to be evaluated using appropriate tools, including the behavioral assessment of injury and non-invasive and post-mortem control of brain damage. These problems also have been summarized in the review.

  5. MR of experimental cerebral ischemia

    International Nuclear Information System (INIS)

    DeLaPaz, R.; Steinberg, G.; Rocklage, S.; Glover, G.H.

    1990-01-01

    This paper reports on MR imaging of cerebral ischemia and treatment with N-methyl-D-aspartate (NMDA) antagonists in an animal model. Forty-four New Zealand white rabbits underwent 1-hour transorbital ICA-MCA-ACA occlusion and pretreatment or immediate posttreatment with systemic dextromethorphan (DM, n = 14), dextrorphan (DX, n = 14), or normal saline (NS, n = 16). Serial MR studies (1.5 T) were performed 1--6 hours after occlusion with T1- and T2-weighted spinecho, IVIM (b = 1,352), gradient recalled acquisition in a steady-state, and chemical shift sequences (for magnetic susceptibility, T2* and T2') and DyDTPA-BMA intravenous contrast material (Salutar). Spatial correlation between MR findings, histologic findings (ischemic neuronal damage), and regional cerebral blood flow (microspheres) was done

  6. Primary cerebral lymphoma: radiological findings

    International Nuclear Information System (INIS)

    Ruiz, J.C.; Grandse, D.; Equidazu, J.; Elizagaray, E.; Grande, J.; Carrandi, J.

    1990-01-01

    We present four cases of primary cerebral lymphoma in non-immunodepressed adult patients. All cases were dsemonstrated with pathological study. CAT study showed solitary or multiple isodense lesions, which incorporated avidly and homoneneously the contrast. Arteriography performed in three patients and magnetic resonance, performed in one did not help for diagnosis. We also review the radiological findings obtained with different imaging methods, and suggest the criteria which could be useful for early diagnosis (Author)

  7. Cerebral hyperperfusion following carotid endarterectomy

    DEFF Research Database (Denmark)

    Schroeder, T; Sillesen, H; Sørensen, O

    1987-01-01

    , occurred in the low pressure ratio group, while the hemispheric asymmetry on average was unchanged in the high pressure ratio group. This relative hyperemia was most pronounced 2 to 4 days following reconstruction. The marked hyperemia, absolute as well as relative, in patients with a low ICA/CCA pressure...... ratio suggests a temporary impairment of autoregulation. Special care should be taken to avoid postoperative hypertension in such patients, who typically have preoperative hypoperfusion, to avoid the occurrence of cerebral edema or hemorrhage....

  8. El Portafolio Digital como estrategia didáctica: la experiencia del curso Servicios de Información Automatizados

    Directory of Open Access Journals (Sweden)

    Ginnette Calvo Guillén

    2014-01-01

    Full Text Available En esta investigación se presenta una experiencia de implementación del Portafolio Digital como estrategia didáctica en dos grupos del curso Servicios de Información Automatizados, pertenecientes al segundo año del tronco común de las carreras de Bachillerato de la Escuela de Bibliotecología y Ciencias de la Información de la Universidad de Costa Rica. La estrategia fue desarrollada individualmente y tuvo como objetivos construir un sitio web como espacio de reflexión acerca de los aprendizajes alcanzados durante el curso, así como crear un servicio de información para desarrollar destrezas evaluando y seleccionando fuentes de información confiables en línea. Con la estrategia se logró que el estudiantado concientizara sobre su responsabilidad en el proceso de construcción del conocimiento y permitió la realimentación recíproca, así como la identificación de fuentes de información confiables en línea.

  9. MR findings of cerebral palsy

    International Nuclear Information System (INIS)

    Yoon, Sang Hum; Chang, Seung Kuk; Cho, Mee Young; Park, Dong Woo; Kim, Jong Deok; Eun, Choong Ki

    1994-01-01

    To evaluate the MR findings of brain damage in cerebral palised patients and to correlate it with gestational age and the time of damage. A retrospective analysis was performed in 40 patients who underwent MR scanning for evaluation of brain lesion in clinically diagnosed cerebral palsy. Authors classified the patients into two groups as premature and full-term and compared MR findings of the two groups. Abnormal MR findings were noted in 28 cases (70%). Five out of 6 patients who had been born prematurely showed isolate periventricular white matter lesions. Twenty-three out of 34 patients who had been born at full-term showed abnormal MR findings. Of these 23 patients, migration anomalies in 7 patients, isolate periventricular white matter lesions in 3 patients, and other combined periventricular subcortical white matter and deep gray matter lesions in 14 patients were seen. At least, 10 patients(43%) of full term group showed abnormal MRI findings reflecting intrauterine brain damage and all 5 patients of premature group showed isolate periventricular white matter lesions suggesting immaturity of brain. MRI is thought to be very useful in the assessment of brain damage for the patients with cerebral palsy by recognizing the location of the lesion and estimating the time of damage

  10. MR findings of cerebral palsy

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, Sang Hum; Chang, Seung Kuk; Cho, Mee Young; Park, Dong Woo; Kim, Jong Deok; Eun, Choong Ki [Pusan Paik Hospital, Pusan (Korea, Republic of)

    1994-11-15

    To evaluate the MR findings of brain damage in cerebral palised patients and to correlate it with gestational age and the time of damage. A retrospective analysis was performed in 40 patients who underwent MR scanning for evaluation of brain lesion in clinically diagnosed cerebral palsy. Authors classified the patients into two groups as premature and full-term and compared MR findings of the two groups. Abnormal MR findings were noted in 28 cases (70%). Five out of 6 patients who had been born prematurely showed isolate periventricular white matter lesions. Twenty-three out of 34 patients who had been born at full-term showed abnormal MR findings. Of these 23 patients, migration anomalies in 7 patients, isolate periventricular white matter lesions in 3 patients, and other combined periventricular subcortical white matter and deep gray matter lesions in 14 patients were seen. At least, 10 patients(43%) of full term group showed abnormal MRI findings reflecting intrauterine brain damage and all 5 patients of premature group showed isolate periventricular white matter lesions suggesting immaturity of brain. MRI is thought to be very useful in the assessment of brain damage for the patients with cerebral palsy by recognizing the location of the lesion and estimating the time of damage.

  11. Behcet's disease with cerebral vasculitis

    International Nuclear Information System (INIS)

    Scardamaglia, L.; Desmond, P.M.; Gonzales, M.F.; Bendrups, A.; Brodtmann, A.

    2001-01-01

    The case presented illustrates the diagnostic dilemma off neurological involvement in Behcet's disease and other inflammatory diseases. 'Psychiatric' symptoms were present for 2 years without abnormalities on SPECT or MRI and without CSF pleocytosis. Even at the time of fitting, no CSF abnormalities were observed. The preceding psychiatric presentations may have been due to cerebral vasculitis that was exacerbated by withdrawal of steroids. Magnetic resonance imaging is currently the most sensitive imaging modality. Lesions are usually in the brainstem, cerebellum, basal ganglia region or periventricular white matter, and the pons and the mesencephalon are commonly affected. In our patient there was no diencephalic or brainstem involvement. The inflammatory process can appear as a very large lesion, with gadolinium enhancement and significant mass effect, as in our patient. Brain magnetic resonance imaging. Postgadolinium-diethylenetriamine pentaacetic acid, axial image shows two large lesions in the right frontal lobe, with the larger, posterior lesion demonstrating vivid ring enhancement. A central nodule is isodense, with the cerebral white matter within the larger lesion. Surrounding low T 1 signal involves the hemispheric white matter without cortical extension and is consistent with vasogenic oedema. Minor mass effect is demonstrated with bowing of the anterior falx cerebri to the left. Biopsy shows prominent fibrinoid necrosis in small calibre postcapillary venules and cerebral white matter. There are surrounding acute and chronic inflammatory cells and nuclear debris, consistent with vasculitis

  12. Identificação do nicho de progenitores mesenquimais no fígado de embriões e fetos caninos: uma fonte de células-tronco para terapia celular

    Directory of Open Access Journals (Sweden)

    Daniele S. Martins

    2012-12-01

    Full Text Available As células-tronco (CT derivadas dos tecidos fetais (TF foram as mais recentes descobertas entre as CT, e ultimamente tem demonstrado amplo potencial terapêutico, dentre os TF o fígado fetal (FF apresenta grande potencial terapêutico. Este órgão durante o período fetal em mamíferos é um nicho hematopoético transitório, sendo o principal órgão responsável pela hematopoese no feto, além de contribuir com a formação do nicho definitivo na medula óssea adulta, portanto pode ser considerado um nicho de células-tronco mesenquimais (CTM e progenitores. No entanto, pouco se sabe sobre a localização destas células no FF, desta forma o presente estudo visa identificar o nicho de CTM e progenitores em FF de cães, a fim de contribuir com as técnicas de isolamento e extração celular. Em conjunto foi realizada a verificação da expressão do fator de transcrição Oct-3/4 e da proteína delta polimerase do DNA (PCNA. Para a análise foram utilizados cinco embriões e 11 fetos caninos com idades gestacionais variando de 25-60 dias. Os resultados elucidaram a partir de 25 dias de gestação o FF apresentou-se volumoso e composto por todas as estruturas típicas, dentre elas a tríade portal, ductos biliares e ramos das artérias hepáticas. Com 30 dias de gestação foram identificados os primeiros sitos de progenitores mesenquimais (PM enquanto que aos 60 dias os nichos estavam completamente formados com localização semelhante ao fígado adulto (FA. No entanto, células imunopositivas para Oct-3/4 não foram identificadas; sendo assim, destacamos que o FF é uma fonte de PM, apresentando-se como uma alternativa para a utilização terapêutica, bem como para os estudos da biologia do desenvolvimento das CTM e progenitores.

  13. Estudio de la densidad ósea en niños y adolescentes con afectación moderada y severa por parálisis cerebral

    OpenAIRE

    Tatay Díaz, Ángela

    2016-01-01

    Falta palabras claves El término Parálisis Cerebral describe un grupo de trastornos permanentes del movimiento y la postura que provocan limitación de la actividad y que son secundarios a un daño puntual y no progresivo en el cerebro en desarrollo. Los trastornos motores de la Parálisis Cerebral se acompañan con frecuencia de alteraciones sensitivas, perceptivas, cognitivas, de la comunicación y el comportamiento, epilepsia y problemas secundarios a nivel del sistema musculoesquelético. ...

  14. Cerebral energy metabolism during induced mitochondrial dysfunction

    DEFF Research Database (Denmark)

    Nielsen, T H; Bindslev, TT; Pedersen, S M

    2013-01-01

    In patients with traumatic brain injury as well as stroke, impaired cerebral oxidative energy metabolism may be an important factor contributing to the ultimate degree of tissue damage. We hypothesize that mitochondrial dysfunction can be diagnosed bedside by comparing the simultaneous changes...... in brain tissue oxygen tension (PbtO(2)) and cerebral cytoplasmatic redox state. The study describes cerebral energy metabolism during mitochondrial dysfunction induced by sevoflurane in piglets....

  15. Cerebral blood flow response to functional activation

    DEFF Research Database (Denmark)

    Paulson, Olaf B; Hasselbalch, Steen G; Rostrup, Egill

    2010-01-01

    Cerebral blood flow (CBF) and cerebral metabolic rate are normally coupled, that is an increase in metabolic demand will lead to an increase in flow. However, during functional activation, CBF and glucose metabolism remain coupled as they increase in proportion, whereas oxygen metabolism only inc...... the cerebral tissue's increased demand for glucose supply during neural activation with recent evidence supporting a key function for astrocytes in rCBF regulation....

  16. CHILDREN AND ADOLESCENTS WITH CEREBRAL PALSY: ANALYSIS OF CARE LONGETUDINALITY

    Directory of Open Access Journals (Sweden)

    Keite Helen dos Santos

    2017-01-01

    Full Text Available Objetivo: analizar la longitudinal del cuidado percibida por los cuidadores de niños y adolescentes con parálisis cerebral. Método: investigación cualitativa, descriptiva, realizada con 27 cuidadores, por medio de entrevistas, analizadas con la técnica de análisis temática con base en la longitudinal del cuidado. Resultados: apuntaron la necesidad de extrema dedicación de los cuidadores a los cuidados de sus niños y adolescentes con parálisis cerebral, siendo necesaria la abdicación al tiempo libre, a las actividades diarias y el abandono de las actividades profesionales. A medida que el niño crece aumenta la complejidad de las actividades diarias y consecuentemente, el pronunciamiento de las dificultades vividas por las familias. Los discursos demostraron la ausencia/deficiencia vividas por las familias. Los discursos demostraron la ausencia/deficiencia de las respuestas formales del Estado a las necesidades integrales del cuidado a la población estudiada, condición que contribuye a naturalizar ese apoyo como responsabilidad familiar. Indican la inexistencia de una red desarticulada de cuidado para esta población, implicando la discontinuidad de atención entre los servicios e impactando en la calidad de vida de los niños y sus familias. Conclusión: la falta de articulación entre los servicios implica discontinuidad de la atención a la salud, deteriorando la calidad de vida de los niños y de sus familias e impactando negativamente en los resultados sanitarios del sistema de atención a la salud, una vez que hay utilización ineficiente de los recursos. El establecimiento de flujos de cuidado es un componente indisociable de la gestión de los servicios de atención, responsable por la garantía de equidad e integralidad a los sujetos investigados.

  17. Efecto de un programa de fisioterapia con hipoterapia sobre el equilibrio en sedestación en niños con parálisis cerebral espástica. Estudio piloto experimental

    OpenAIRE

    Rivas Carabias, Ana

    2014-01-01

    Trabajo Fin de Grado (TFG) Introducción: La parálisis cerebral es una patología que afecta a 2,5 niños nacidos vivos por cada 1000, y que consiste en un grupo de trastornos permanentes y no progresivos en el Sistema Nervioso Central, que se produce durante el desarrollo cerebral del feto o del lactante, afectando al desarrollo del movimiento y la postura y teniendo una etiología muy diversa. Se caracteriza por un retraso en el desarrollo motor, alteración de la activación de...

  18. Cerebral Palsy. Fact Sheet = La Paralisis Cerebral. Hojas Informativas Sobre Discapacidades.

    Science.gov (United States)

    National Information Center for Children and Youth with Disabilities, Washington, DC.

    This fact sheet on cerebral palsy is written in both English and Spanish. First, it provides a definition of cerebral palsy and considers various causes (e.g., an insufficient amount of oxygen reaching the fetal or newborn brain). The fact sheet then offers incidence figures and explains characteristics of the three main types of cerebral palsy:…

  19. Cerebral oxygen metabolism and cerebral blood flow in man during light sleep (stage 2)

    DEFF Research Database (Denmark)

    Madsen, P L; Schmidt, J F; Holm, S

    1991-01-01

    . They differ in respect of arousal threshold as a stronger stimulus is required to awaken a subject from deep sleep as compared to light sleep. Our results suggest that during non-rapid eye movement sleep cerebral metabolism and thereby cerebral synaptic activity is correlated to cerebral readiness rather than...

  20. CT findings of cerebral fat embolism

    International Nuclear Information System (INIS)

    Mashiyama, Shoji; Kawakami, Kiyoshi; Ohtsuki, Taisuke; Ishibashi, Takao.

    1986-01-01

    A case of cerebral fat embolism following multiple bone fractures is presented. A 27-year-old patient was admitted to our clinic 50 minutes after a traffic accident. He was somnolent on admission, but his consciousness level was gradually raised and respiratory symptoms (dyspnea, bloody sputum) appeared with petechiae of his conjunctiva and chest. We diagnosed cerebral fat embolism. On CT scan we found multiple high-density areas, which gradually turned into multiple low-density areas. Subsequent cerebral atrophy and subdural effusion developed one month after the injury. This patient showed a typical clinical course and CT findings of cerebral fat embolism. (author)

  1. Genetics Home Reference: cerebral cavernous malformation

    Science.gov (United States)

    ... Additional NIH Resources (1 link) National Institute of Neurological Disorders and Stroke Educational Resources (7 links) Boston Children's Hospital: Cavernous Malformations Disease InfoSearch: Cerebral Cavernous Malformation ...

  2. Acute cerebral vascular accident associated with hyperperfusion

    International Nuclear Information System (INIS)

    Soin, J.S.; Burdine, J.A.

    1976-01-01

    Cerebral radionuclide angiography can demonstrate decreased or normal radioactivity in the affected region during the arterial phase in patients who have sustained a cerebral vascular accident and thus enhances the diagnostic specificity of the static brain image. In an occasional patient, however, a seemingly paradoxical pattern of regional hyperperfusion with a return to normal or subnormal perfusion following the acute phase has been observed. This phenomenon, called luxury perfusion, has been defined using intra-arterial 133 Xe for semiquantitative cerebral blood flow measurements and should be kept in mind as a potentially misleading cerebral imaging pattern

  3. Efecto de cuatro manejos del suelo sobre la densidad de raíces absorbentes en durazno [prunus pérsica (l batsch] a 10 cm de profundidad

    Directory of Open Access Journals (Sweden)

    Andrés Gómez

    2011-10-01

    Full Text Available El árbol de Durazno (P. pérsica está constituido por dos partes estructurales: una epigea, conformada por el tronco que soporta el sistema caulinar, y otra hipogea que constituye el sistema radicular. Este último, de acuerdo con la base morfoanatómica y las funciones específicas, presenta varios tipos de raíces: absorbentes, de transición y de conducción. Las absorbentes (de color blanquecino translúcido son fisiológicamente muy activas y representanentre el 80 y el 85% de la totalidad del sistema radical. Aunque las raícesde los árboles frutales se desarrollan siguiendo un patrón genético, algunas condiciones medio ambientales producen variaciones morfológicas en su desarrollo. En este trabajo se estudió la densidad del aparato radical absorbente en el cultivo de Durazno (variedad Dorado, a 10 cm de profundidad. Se empleó la técnica volumen del cilindro, en función del manejo del suelo, utilizando 2 tipos de coberturas (cobertura viva, cobertura muerta, control dearvenses con herbicida y un referente tradicional con labranza. Los resultados mostraron que la cobertura con material vegetal muerto, sobre el suelo (10 cm de profundidad bajo el diámetro de la copa del árbol (160 cm, generóun mayor desarrollo del sistema radicular, evidente en una mayor densidad.

  4. Culturas del Mundo

    DEFF Research Database (Denmark)

    Benwell, Ann Fenger; Costa, Alberto; Waehle, Espen

    2006-01-01

    ’Culturas del mundo. Colecciones del Museo Nacional de Dinamarca’ with Ann Fenger Benwell in Culturas del Mundo. Colecciones del Museo Nacional de Dinamarca, ed. Silvia Sauquet, Fundación "la Caixa", Barcelona 2006, pp. 31-39......’Culturas del mundo. Colecciones del Museo Nacional de Dinamarca’ with Ann Fenger Benwell in Culturas del Mundo. Colecciones del Museo Nacional de Dinamarca, ed. Silvia Sauquet, Fundación "la Caixa", Barcelona 2006, pp. 31-39...

  5. Infusion of Hematopoietic Stem Cells: Types, Characteristics, Adverse and Transfusion Reactions and the Implications for Nursing Infusión de células madre hematopoyéticas: tipos, características, reacciones adversas y de transfusión y sus implicaciones para la enfermería Infusão de células-tronco hematopoéticas: tipos, características, reações adversas e transfusionais e implicações para a enfermagem

    Directory of Open Access Journals (Sweden)

    Ana Carolina de Jesus Vieira Curcioli

    2010-08-01

    periférica. La documentación de enfermería es relevante tanto para la seguridad del paciente como para la planificación de la infusión, a fin de minimizar la ocurrencia de las reacciones.A infusão de células-tronco hematopoéticas é importante procedimento no transplante de células-tronco hematopoéticas. Este estudo se propôs a identificar as reações adversas e transfusionais que podem ocorrer durante a infusão e os cuidados de enfermagem inerentes ao procedimento. Trata-se de estudo epidemiológico em transplantes, ocorridos entre os anos 2006 e 2008. Ocorreram 166 transplantes, sendo 114 autólogos, 47 alogênicos e 5 haploidênticos. Observaram-se três reações transfusionais e 96 reações adversas. As reações adversas estão ligadas à presença do crioprotetor. No entanto, velocidade de infusão e quantidade do crioprotetor infundido não tiveram relação com a ocorrência das reações. Nas reações transfusionais, os produtos eram frescos e infundidos na velocidade preconizada. Quanto às fontes de células, houve menor tempo de enxertia no sangue periférico. A documentação de enfermagem é relevante tanto para a segurança do paciente como para o planejamento da infusão, a fim de minimizar a ocorrência das reações.

  6. O direito à vida no contexto do aborto e da pesquisa com células-tronco embrionárias: disputas de agentes e valores religiosos em um estado laico

    Directory of Open Access Journals (Sweden)

    Naara Luna

    2013-01-01

    Full Text Available O artigo aborda o debate público sobre o direito à vida no contexto da autorização da pesquisa com células-tronco embrionárias e no debate sobre o aborto, enfocando a participação de atores religiosos e seus valores. Serão examinados o debate legislativo e judiciário da Lei de Biossegurança e a audiência pública da ADPF 54, referente à antecipação de parto de anencéfalo. Esta pesquisa documental analisa a transcrição da audiência pública da ADPF 54, e os registros do processo legislativo no Congresso Nacional e da ADI 3510 no Supremo Tribunal Federal. Os resultados revelam, além da centralidade do argumento do valor da vida, a diversidade na atuação dos agentes religiosos, com hegemonia da Igreja Católica e a emergência de evangélicos e espíritas.

  7. HIBRIDISMO CULTURAL E OBLIQÜIDADE DE PODER: UMA ANÁLISE DAS DISCUSSÕES PÚBLICAS SOBRE CÉLULAS-TRONCO EMBRIONÁRIAS NO CONTEXTO SOCIAL BRASILEIRO

    Directory of Open Access Journals (Sweden)

    Anielle Aparecida Fernandes de Morais

    2008-01-01

    Full Text Available El presente trabajo pretende mostrar los aspectos socioculturales que conducen las discusiones sobre el uso de las células tronco embrionarias en encuestas brasileñas contra enfermedades degenerativas. El artículo se basa en el análisis de tres reportajes publicados en el periódico Folha Online entre marzo y mayo de 2008, período que corresponde a la votación de la propuesta de la acción de inconstitucionalidad dispuesta por el procurador general de la República de la época, Cláudio Fonteles. Así entonces, se propone un estudio sobre el debate discursivo entre la ciencia y la religión, con el objetivo de valorar como ocurre la articulación de ideas, políticas e ideologías para la producción de bienes simbólicos en el contexto más amplio de las relaciones socioculturales. Se parte de la premisa que los medios tienen vital importancia en el espacio social donde se gestan las discusiones y producción de visibilidades publicas, pretendemos verificar como se gesta en los medios la representación y la construcción de la cadena de significaciones culturales y discursiva en torno a este debate.

  8. Consenso brasileiro para transplante de células-tronco hematopoéticas para tratamento de doenças autoimunes Brazilian consensus on hematopoietic stem cell transplantation for autoimmune diseases

    Directory of Open Access Journals (Sweden)

    Júlio C. Voltarelli

    2010-05-01

    Full Text Available Neste trabalho, foram revisadas a literatura internacional e a experiência nacional com transplante de células-tronco hematopoéticas (TCTH para doenças autoimunes. A evidência acumulada indica que o TCTH autólogo pode beneficiar pacientes com esclerose múltipla em fase inflamatória, refratária aos tratamentos medicamentosos disponíveis, e pacientes com esclerose sistêmica cutânea difusa de caráter progressivo, com ou sem comprometimento sistêmico. Esse tratamento deveria ser disponibilizado na rede pública de saúde, numa fase inicial, em centros de referência com experiência em TCTH e no manejo clínico de doenças autoimunes sistêmicas graves.In this paper, international literature and national experience on hematopoietic stem cell transplantation (HSCT for autoimmune diseases were reviewed. Cumulative evidence indicates that autologous HSCT may benefit patients with inflammatory multiple esclerosis, refractory to available drug therapy, and progressive forms of diffuse cutaneous systemic sclerosis with or without systemic involvement. Initially, this treatment should be available in reference centers of the public health system, with experience in performing HSCT and in treating severe systemic autoimmune diseases.

  9. Estudio de las subpoblaciones linfocitarias T en pacientes pediátricos con anomalías tronco-conales cardiovasculares Study of the T-lymphocyte subpopulations in pediatric patients with conal-truncal cardiovascular abnormalities

    Directory of Open Access Journals (Sweden)

    Bertha Beatriz Socarrás Ferrer

    2006-12-01

    Full Text Available Se estudiaron en 20 pacientes pediátricos con anomalías tronco-conales cardiovasculares las subpoblaciones de linfocitos T mediante el método de la fosfatasa alcalina antifosfatasa alcalina con los anticuerpos monoclonales específicos anti-CD3, anti-CD4 y anti-CD8. Se tomó como grupo control a 25 individuos supuestamente sanos. Se obtuvieron diferencias significativas para las subpoblaciones T CD3 y CD4 positivas (p The T-lymphocyte subpopulations were studied in 20 pediatric patients with conal-truncal cardiovascular abnormalities by the alkaline phosphatase alkaline antiphosphatase method with the anti-CD3, anti-CD4, and anti-CD8 specific monoclonal antibodies. 25 apparently sound individuals were selected as the control group. Significant differences were obtained for the CD3- and CD4-positive T cell subpopulations (p< 0.05. The cellular immunological deficit found in these patients shows the need to include immunomodulators in their treatment to prevent septic complications

  10. Valoración del plano sagital de la columna vertebral y la extensibilidad de la musculatura isquiosural en gimnastas de trampolín

    OpenAIRE

    Rodríguez Iniesta, María

    2015-01-01

    Objetivos. Se valoró la disposición sagital de la columna vertebral en gimnastas especialistas en la modalidad de trampolín. Material y métodos. Se realizó un estudio transversal, en el que participaron 91 gimnastas de trampolín (47 mujeres y 44 varones) con una edad media de 15,57+4,69 años, y de 7+4,14 años de entrenamiento. La valoración se realizó en tres posiciones: bipedestación relajada, sedentación relajada y flexión máxima del tronco. En todas las posiciones se diferenció la curva d...

  11. Neuroimágenes en las alteraciones del sueño

    OpenAIRE

    Dr. M. Marcelo Gálvez

    2013-01-01

    Las imágenes médicas han representado un importante avance en el estudio de las enfermedades del sistema nervio cerebral. Sin embargo existe un importante grupo de enfermedades que se caracterizan por la ausencia o una muy leve alteración de la estructura cerebral que son muy difíciles de detectar utilizando imágenes convencionales, como las enfermedades psiquiátricas, algunos tipos de epilepsia y las alteraciones del sueño. Las alteraciones de la estructura se pueden estudiar más detallad...

  12. Multiple cerebral aneurysms of middle cerebral artery. Case report

    Directory of Open Access Journals (Sweden)

    D.A. Nica1, Tatiana Rosca1, A. Dinca2, M. Stroi3, Mirela Renta4, A.V. Ciurea5

    2010-11-01

    Full Text Available Multiple cerebral aneurysms present awide variation in incidence with averages of13% at angiographic studies and 22.7% atautopsy.High blood pressue, cigarette smoking,stress and possible also age and female sexseem to be risk factors for multipleintracranial aneurysms (MIAn in patientsof working age who have suffered asubarachnoid hemorrhage (SAH.Aneurysms were situated on the same sidein one-third of the patients with twoaneurysms and the most common site wasthe middle cerebral artery (MCA. Tomanage these challenging lesionsneurosurgeons must use all availableinnovations and advances, includingdiagnostic, technical and perioperativeadjuncts. The author presents a case ofmiddle age female, with two saccularaneurysms situated on the same side (rightMCA, who was operated in our clinic, 20days after first SAH episode, I grade onHunt/Hess scale. The angio MRI wasperformed before, and control DSangiography after operation. After pterionalapproach, the author used themagnification, microsurgical technics,temporal clip, and two permanent Yasargilcurved clips. A postoperative good recoveryenable the patient go to work and drive onemonth later.

  13. Dominant inheritance of cerebral gigantism.

    Science.gov (United States)

    Zonana, J; Sotos, J F; Romshe, C A; Fisher, D A; Elders, M J; Rimoin, D L

    1977-08-01

    Cerebral gigantism is a syndrome consisting of characteristic dysmorphic features, accelerated growth in early childhood, and variable degrees of mental retardation. Its etiology and pathogenesis have not been defined. Three families are presented with multiple affected members. The vertical transmission of the trait and equal expression in both sexes in these families indicates a genetic etiology with a dominant pattern of inheritance, probably autosomal. As in previously reported cases, extensive endocrine evaluation failed to define the pathogenesis of the accelerated growth present in this disorder.

  14. Models of Cerebral System Mechanics.

    Science.gov (United States)

    1986-07-20

    elements CBV and C,, are added between the brain tissue and the venous compartments, and between the cerebro - spinal fluid and the venous sinus...impact and whiplash in primates . J. Biomech., 4, 13-21. RYDER, H. W., ESPEY, F. F., KIMBELL, F. D., PENKA, E. J., ROSENAUER, A., PODOLSKY, B. and EVANS...Hirsch, A.E. (1971) Tolerances for cerebral concussion from head impact and whiplash in primates . J. Biomech. 4:13-21. Pamidi, M.R. and Advani, S.H. (1978

  15. Hyperthyroidism and cerebral venous thrombosis.

    Science.gov (United States)

    Mouton, S; Nighoghossian, N; Berruyer, M; Derex, L; Philippeau, F; Cakmak, S; Honnorat, J; Hermier, M; Trouillas, P

    2005-01-01

    The demonstration of an underlying prothrombotic condition in cerebral venous thrombosis (CVT) may have important practical consequences in terms of prevention. Thyrotoxicosis through a hypercoagulable state may be a predisposing factor for CVT. The authors present the cases of 4 patients who developed CVT and hyperthyroidism. At the acute stage, hyperthyroidism was associated with an increase in factor VIII (FVIII). At follow-up, FVIII level remained increased in 2 patients. Hyperthyroidism may have an impact on FVIII level. Accordingly in patients with hyperthyroidism and neurological symptoms, the diagnosis of CVT should be considered and an exhaustive coagulation screening may be appropriate. (c) 2005 S. Karger AG, Basel.

  16. Schizencephaly/congenital cerebral clefts

    International Nuclear Information System (INIS)

    Friedman, H.; Naidich, T.P.

    1987-01-01

    Schizencephaly (from the Greek meaning ''split brain''), is a term developed in the 1940s to explain symmetric clefts in the brain seen at autopsy in children with histories of severe neurologic defects. Use of the term has been expanded to include a variety of cerebral clefts. A review of the experience at Children's Memorial Hospital as well as case materials made available to the authors are presented, including CT, MR imaging, and US findings. Theories of etiology and pathogenesis of these congenital clefts, associated anomalies, and the spectrum of appearance of these clefts are discussed

  17. LIPOMA CEREBRAL EN CUERPO CALLOSO: HALLAZGO INCIDENTAL EN PACIENTE CON EVENTO CEREBROVASCULAR

    Directory of Open Access Journals (Sweden)

    Gloria Cárcamo-Portillo

    2016-07-01

    Full Text Available Los lipomas intracraneales son lesiones infrecuentes y benignas que representan el 0,03 al 0,08% de todas las masas intracraneales. Estos se encuentran relacionados a un defecto de la línea media debido a un mal cierre del tubo neural; lo que conlleva a una mala diferenciación y una persistencia anormal de la meninge primitiva con posterior diferenciación al tejido adiposo. La mitad de los casos permanecen asintomáticos y son diagnosticados como un hallazgo incidental en los estudios imagenológicos. Sin embargo, otros casos se asocian a sintomatología neurológica como retraso psicomotor, cefalea, epilepsia y parálisis cerebral. Se presenta el caso de una paciente de 46 años de edad, con antecedentes de hipertensión arterial y diabetes mellitus tipo 2; que cursa con sintomatología de Evento Cerebrovascular Isquémico por lo que le realizan –una Tomografía Computarizada (TC y una Resonancia Magnética (RM. En el reporte se describen múltiples infartos a nivel del hemisferio cerebral izquierdo mientras que al nivel de la línea media se observó una imagen compatible con lipoma cerebral que afectaba el rostro, la rodilla y la porción anterior del cuerpo calloso. La identificación de este hallazgo fue incidental. Palabras claves: Lipoma Cerebral; Cuerpo Calloso; Resonancia Magnética; Accidente Cerebrovascular. (Fuente: DeCS BIREME.

  18. ABSCESO CEREBRAL MULTICÉNTRICO CAUSADO POR ENTAMOEBA HISTOLYTICA

    OpenAIRE

    CASTILLO DE LA CRUZ,MANUEL; JOSÉ LUIS,GALLEGOS BARREDO; MENDIZÁBAL GUERRA,RAFAEL; FÉLIX,IGNACIO; RIVAS,ANGÉLICA

    2004-01-01

    La infección amibiana del sistema nervioso central casi siempre es precedido de un absceso pulmonar o hepático. El absceso cerebral amibiano es raro y sólo se han publicado alrededor de 100 casos en el mundo. La mayoría de los reportes son de la era de la tomografía y hay muy pocos casos con imágenes de resonancia magnética, en ambos estudios, no puede diferenciarse de otro tipo de absceso. El diagnóstico es histopatológico y el tratamiento de elección es el metronidazol. Se reporta el caso d...

  19. Middle cerebral artery blood velocity during running

    NARCIS (Netherlands)

    Lyngeraa, T. S.; Pedersen, L. M.; Mantoni, T.; Belhage, B.; Rasmussen, L. S.; van Lieshout, J. J.; Pott, F. C.

    2013-01-01

    Running induces characteristic fluctuations in blood pressure (BP) of unknown consequence for organ blood flow. We hypothesized that running-induced BP oscillations are transferred to the cerebral vasculature. In 15 healthy volunteers, transcranial Doppler-determined middle cerebral artery (MCA)

  20. Mobility Experiences of Adolescents with Cerebral Palsy

    Science.gov (United States)

    Palisano, Robert J.; Shimmell, Lorie J.; Stewart, Debra; Lawless, John J.; Rosenbaum, Peter L.; Russell, Dianne J.

    2009-01-01

    The purpose of this study was to describe how youth with cerebral palsy experience mobility in their daily lives using a phenomenological approach. The participants were 10 youth with cerebral palsy, 17 to 20 years of age, selected using purposeful sampling with maximum variation strategies. A total of 14 interviews were completed. Transcripts…

  1. OCULAR FINDINGS IN CHILDREN WITH CEREBRAL PALSY ...

    African Journals Online (AJOL)

    Cerebral palsy is commonly associated with ocular abnormalities which often impact on their development and education. There is paucity of studies on this in Nigeria. We decided to study/ determine the prevalence of ocular abnormalities among children with cerebral palsy that attended the neurology clinic of University of ...

  2. Acute hypoxia increases the cerebral metabolic rate

    DEFF Research Database (Denmark)

    Vestergaard, Mark Bitsch; Lindberg, Ulrich; Aachmann-Andersen, Niels Jacob

    2016-01-01

    The aim of the present study was to examine changes in cerebral metabolism by magnetic resonance imaging of healthy subjects during inhalation of 10% O2 hypoxic air. Hypoxic exposure elevates cerebral perfusion, but its effect on energy metabolism has been less investigated. Magnetic resonance im...

  3. Cerebral emboli and depressive symptoms in dementia.

    NARCIS (Netherlands)

    Purandare, N.; Oude Voshaar, R.C.; Hardicre, J.; Byrne, J.; McCollum, C.N.; Burns, A.

    2006-01-01

    BACKGROUND: The vascular depression hypothesis and our recent findings of increased frequency of spontaneous cerebral emboli in dementia suggest that such emboli may be involved in the causation of depressive symptoms in dementia. AIMS: To evaluate the association between spontaneous cerebral emboli

  4. Animal models of cerebral arterial gas embolism

    NARCIS (Netherlands)

    Weenink, Robert P.; Hollmann, Markus W.; van Hulst, Robert A.

    2012-01-01

    Cerebral arterial gas embolism is a dreaded complication of diving and invasive medical procedures. Many different animal models have been used in research on cerebral arterial gas embolism. This review provides an overview of the most important characteristics of these animal models. The properties

  5. MRI of sickle cell cerebral infarction

    International Nuclear Information System (INIS)

    Zimmerman, R.A.; Goldberg, H.I.; Bilaniuk, L.T.; Hackney, D.B.; Johnson, M.; Grossman, R.I.; Hecht-Leavitt, C.; Gill, F.; Pennsylvania Univ., Philadelphia

    1987-01-01

    Eleven patients with sickle cell disease and neurological symptoms underwent MRI examination. Cerebral infarcts of two types were found, those in the vascular distribution of the middle cerebral artery and those in the deep white matter. In the patient whose hydration and whose oxygenation of erythrocytes has been treated, MRI offers diagnostic advantages over arteriography and CT. (orig.)

  6. Non operative management of cerebral abscess

    Science.gov (United States)

    Batubara, C. A.

    2018-03-01

    Cerebral abscess is a focal intracerebral infection that begins as a localized area of cerebritis and develops into a collection of pus surrounded by a well-vascularized capsule. Patients typically present with varying combinations of aheadache, progressive neurologic deficits, seizures, and evidence of infection. Computed Tomography and Magnetic Resonance Imagingare the most important diagnostic tools in diagnosing cerebral abscess. The treatment of cerebral abscess has been a challenge. Small cerebralabscesses (managed by the use of intravenous mannitol (or hypertonic saline) and dexamethasone. Acute seizures should be terminated with the administration of intravenous benzodiazepines or by intravenous fosphenytoin. Anticonvulsants prophylaxis must be initiated immediately and continued at least one year due to high risk in the cerebral abscesses. Easier detection of underlying conditions, monitoring of the therapeutic progress, and recognition of complications have probably contributed to the improved prognosis.

  7. CT findings in patients with cerebral palsy

    International Nuclear Information System (INIS)

    Konno, Kimiichi

    1982-01-01

    Clinical findings and CT findings in 73 cases of cerebral palsy were studied. The causes of cerebral palsy were presumed to be as follows: abnormal cerebral development (36%), asphyxial delivery (34%), and immature delivery (19%), etc. CT findings were abnormal in 58% of the 73 cases, 83% of the spastic tetraplegia patients and all of the spastic hemiplegia patients showed abnormal CT findings. All the patients with spastic monoplegia presented normal CT findings. In 75% of the spastic hemiplegia cases, the CT abnormalities were due to cerebral parenchymal abnormality such as porencephaly and regional low absorption. In cases of spastic tetraplegia, cerebral parenchymal abnormality was found only in 10%. Cortical atrophy was found only in 15 of the 73 cases, whereas central atrophy was found in 36 cases. (Ueda, J.)

  8. Evaluation of cerebral blood flow, cerebral metabolism and cerebral function by magnetic resonance imaging

    International Nuclear Information System (INIS)

    Tanaka, Chuzo; Higuchi, Toshihiro; Umeda, Masahiro; Naruse, Shoji; Horikawa, Yoshiharu; Ueda, Satoshi; Furuya, Seiichi.

    1995-01-01

    The magnetic resonance (MR) method has the unique potentiality of detecting cerebral metabolites, cerebral blood flow and brain functions in a noninvasive fashion. We have developed several MR techniques to detect these cerebral parameters with the use of clinical MRI scanners. By modifying the MR spectroscopy (MRS) technique, both 31 P- and 1 H-MRS data can be obtained from multiple, localized regions (multi-voxel method) of the brain, and the distribution of each metabolite in the brain can be readily visualized by metabolite mapping. The use of diffusion weighted images (DWI) permits visualization of the anisotropy of water diffusion in white matter, and based on the difference of diffusion coefficiency, the differential diagnosis between epidermoid tumor and arachnoid cyst can be made. By employing dynamic-MRI (Dyn-MRI) with Gd-DTPA administration, it is possible to examine the difference in blood circulation between brain tumor tissue and normal tissue, as well as among different types of brain tumors. By using magnetization transfer contrast (MTC) imaging, it has become possible to detect brain tumors, and with a small dose of Gd-DTPA, to visualize the vascular system. Functional MRI (fMRI) visualizes the activated brain by using conventional gradient echo technique on conventional MRI scanners. This method has the unique characteristic of detecting a brain function with high spatial and temporal resolution by using the intrinsic substance. Moreover, the localization of motor and sensory areas was detected by noninvasive means within few minutes. The fMRI procedure will be used in the future to analyze the higher and complex brain functions. In conclusion, multi-modality MR is a powerful technique that is useful for investigating the pathogenesis of many diseases, and provides a noninvasive analytic modality for studying brain function. (author)

  9. Tomografía cerebral, SPECT cerebral y neurocognición en trauma craneoencefálico

    OpenAIRE

    Casallo Quiliano, Carlos

    2013-01-01

    Introduccion: La tomografía cerebral (TC) es el examen de elección para evaluar un trauma cráneo encefálico (TCE) agudo. Otras pruebas, como la tomografía computarizada por emisión de fotón único (SPECT) están siendo utilizadas en el TCE, siendo mejor que la TC o la Resonancia magnética (RM) en la evaluación funcional del cerebro. La mayoría de estudios no incluyen, ni relacionan los resultados de la TC y SPECT con la evaluación neuropsicológica, la cual puede estar alterada a pesar de tener ...

  10. Lifetime costs of cerebral palsy

    DEFF Research Database (Denmark)

    Kruse, Marie; Michelsen, Susan Ishøy; Flachs, Esben Meulengracht

    2009-01-01

    This study quantified the lifetime costs of cerebral palsy (CP) in a register-based setting. It was the first study outside the US to assess the lifetime costs of CP. The lifetime costs attributable to CP were divided into three categories: health care costs, productivity costs, and social costs....... social care costs and productivity costs associated with CP point to a potential gain from labour market interventions that benefit individuals with CP.......This study quantified the lifetime costs of cerebral palsy (CP) in a register-based setting. It was the first study outside the US to assess the lifetime costs of CP. The lifetime costs attributable to CP were divided into three categories: health care costs, productivity costs, and social costs...... in 2000. The prevalence of CP in eastern Denmark was approximately 1.7 per 1000. Information on productivity and the use of health care was retrieved from registers. The lifetime cost of CP was about euro860 000 for men and about euro800 000 for women. The largest component was social care costs...

  11. Radiotherapy in primary cerebral lymphoma

    International Nuclear Information System (INIS)

    Legros, L.; Benezery, K.; Lagrange, J.L.

    1999-01-01

    Primary cerebral lymphoma is a rare disease with an unfavorable prognosis. Whole brain radiotherapy has been the standard treatment, but neither the optimal radiation fields nor optimal dose level of the regimen are as yet firmly establisheD. From this review of the literature, it seems that the whole brain must be treated, and a boost to the area of the primary site must be discussed. With regard to dose, the radiation dose-response relationship is not clearly proven. Yet, a minimum dose of 40 Gy is necessary, and the maximum dose is set at 50 Gy because of late neurological sequelae. Because of the poor prognosis of this disease and the risk of late sequelae, other avenues have been explored. Chemotherapy has been studied, seem to have a survival advantage and combinations of radiotherapy and chemotherapy, especially with high-dose methotrexate. Because primary cerebral lymphoma is an uncommon disease, randomized clinical trials that compare radiotherapy alone to chemotherapy plus radiotherapy may not be feasible. Finally, even if chemotherapy seems to have a survival advantage, the regimen of chemotherapy is still a matter of debate. (authors)

  12. Cerebral cortex modulation of pain

    Institute of Scientific and Technical Information of China (English)

    Yu-feng XIE; Fu-quan HUO; Jing-shi TANG

    2009-01-01

    Pain is a complex experience encompassing sensory-discriminative, affective-motivational and cognitiv e-emotional com-ponents mediated by different mechanisms. Contrary to the traditional view that the cerebral cortex is not involved in pain perception, an extensive cortical network associated with pain processing has been revealed using multiple methods over the past decades. This network consistently includes, at least, the anterior cingulate cortex, the agranular insular cortex, the primary (SⅠ) and secondary somatosensory (SⅡ) cortices, the ventrolateral orbital cortex and the motor cortex. These corti-cal structures constitute the medial and lateral pain systems, the nucleus submedius-ventrolateral orbital cortex-periaque-ductal gray system and motor cortex system, respectively. Multiple neurotransmitters, including opioid, glutamate, GABA and dopamine, are involved in the modulation of pain by these cortical structures. In addition, glial cells may also be in-volved in cortical modulation of pain and serve as one target for pain management research. This review discusses recent studies of pain modulation by these cerebral cortical structures in animals and human.

  13. Neuroimaging patterns of cerebral hyperperfusion

    Science.gov (United States)

    Semenov, S.; Portnov, Yu; Semenov, A.; Korotkevich, A.; Kokov, A.

    2017-08-01

    Cerebral hyperperfusion syndrome (CHS) after revascularization is a rare phenomenon associated with post-ischemic (reactive) hyperemia and acute pathological hyperperfusion. First described on perfusion CT as a very often moderate CBF increase, MTT/TTP decrease within 30% like a temporary effect, according to a short-time deterioration of neurological symptoms (vestibular ataxia - 58%, vegetative dysfunction - 100%, asthenic syndrome - 100%) in early postoperative period in patients with cardiac ischemia who had undergone coronary artery bypass surgery. The acute pathological hyperperfusion carotid revascularization is a casuistic phenomenon with two- or three-fold CBV and MTT/TTP increase and high hemorrhage risk. Besides, we detected similar exchanges via perfusion CT called benign hyperemia, which marks extension of MTT/TTP and an increase of CBV from 27% to 48% (average 30%), but with normal CBF-parameters, indicating that venous stasis in acute venous ischemic stroke due cerebral venous sinus-trombosis (68%), only 6% in cardioembolic stroke and appears never in arterial stroke. Territorial coincidence registered for perifocal of necrosis zones of benign hyperemia and vasogenic edema accompanied on MRI (DWI, ADC). Secondary hemorrhagic transformation registered for primary non-hemorrhagic venous stroke in 27%, only in 9% for arterial stroke and in 60% for cardioembolic stroke. Probably, congestion is an increasingly predisposing factor secondary hemorrhaging than necrosis.

  14. Cerebral vasculitis associated with Schistosoma mansoni infection

    Directory of Open Access Journals (Sweden)

    Camuset Guillaume

    2012-09-01

    Full Text Available Abstract Background Cerebral involvement in schistosomiasis is not rare, but it is underdiagnosed because of the lack of clinical suspicion and the frequency of asymptomatic forms. Neurologic complications are generally supported by granuloma formation around ectopic eggs which have migrated to the brain. Moreover, vascular lesions and cerebral arteritis have been well documented in histopathological studies. Nevertheless, cerebral vasculitis in later stages of the Schistosoma mansoni infection have not yet been described in living subjects. Case presentation A 28-year-old french woman had a stroke linked with cerebral vasculitis, 6 monthes after returning from Burkina-Faso. At the same time, a S. mansoni disseminated infection was diagnosed. She suffered from a new stroke after undertaking praziquantel therapy, which lead us to associate the S. mansoni infection and cerebral vasculitis. Conclusion This is the first report of such association, since cerebral vasculitis has never been described in later stages of the S. mansoni infection. Although the causal link between the two pathologies could not be proved, we suggest that S. mansoni is able to cause severe vascular damage in cerebral vessels. Schistosomiasis must be investigated in the event of a brain infarct in young people, particularly in patients originating or returning from an endemic area.

  15. Cerebral intolerance during flow arrested carotid angioplasty.

    Science.gov (United States)

    St Louis, Myron; Park, Brian D; Dahn, Michael; Bozeman, Patricia

    2012-01-01

    The use of flow arrest as a means of providing cerebral protection during carotid angioplasty offers the advantages of improved efficiency of debris removal and the ability to provide protection under unfavorable (tortuous) anatomic circumstances. However, in contrast to the filtration methods of cerebral protection, this modality requires complete interruption of antegrade carotid artery flow during balloon angioplasty and stent deployment. We report our experience with 9 patients undergoing carotid angioplasty with the Mo.Ma device, which utilizes common and external carotid artery balloon occlusion during the angioplasty procedure. We assessed the clinical outcomes and intraprocedural hemodynamic data. The average duration of carotid occlusion was 8.3 minutes. Of the 9 patients, 2 patients (22%) experienced cerebral intolerance. No stroke occurred in this patient cohort. There appeared to be a poor relationship between procedure intolerance and the presence of significant contralateral stenosis or low carotid back pressure. Furthermore, the incidence of postangioplasty hypotension was not clearly related to cerebral intolerance. Carotid angioplasty with stenting can be safely conducted with flow arrest as an alternative to filter-type cerebral protection devices. However, because cerebral intolerance is not an infrequent occurrence with this approach, clinicians must be cognizant of management strategies for transient cerebral intolerance.

  16. Cerebellar malformations alter regional cerebral development.

    Science.gov (United States)

    Bolduc, Marie-Eve; Du Plessis, Adre J; Evans, Alan; Guizard, Nicolas; Zhang, Xun; Robertson, Richard L; Limperopoulos, Catherine

    2011-12-01

    The aim of this study was to compare total and regional cerebral volumes in children with isolated cerebellar malformations (CBMs) with those in typically developing children, and to examine the extent to which cerebellar volumetric reductions are associated with total and regional cerebral volumes. This is a case-control study of children diagnosed with isolated CBMs. Each child was matched on age and sex to two typically developing children. Using advanced three-dimensional volumetric magnetic resonance imaging, the cerebrum was segmented into tissue classes and partitioned into eight regions. Analysis of variance was used to compare cerebral volumes between children with CBMs and control children, and linear regressions to examine the impact of cerebellar volume reduction on cerebral volumes. Magnetic resonance imaging was performed at a mean age of 27 months in 20 children (10 males, 10 females) with CBMs and 40 typically developing children. Children with CBMs showed significantly smaller deep grey matter nuclei (p developing children. Greater cerebellar volumetric reduction in children with CBMs was associated with decreased total cerebral volume and deep grey matter nuclei (p = 0.02), subgenual white/grey matter (p = 0.001), midtemporal white (p = 0.02) and grey matter (p = 0.01), and parieto-occipital grey matter (p = 0.004). CBMs are associated with impaired regional cerebral growth, suggesting deactivation of principal cerebello-cerebral pathways. © The Authors. Developmental Medicine & Child Neurology © 2011 Mac Keith Press.

  17. La osteopatía craneal no mejora el estado de salud de niños con parálisis cerebral.

    OpenAIRE

    Molina Arias, Manuel; González de Dios, Javier

    2011-01-01

    Este artículo pretende valorar el efecto del tratamiento con osteopatía craneal (OC) sobre la salud general, la función motora y la calidad de vida de niños con parálisis cerebral (PC), así como el efecto sobre la calidad de vida de sus cuidadores.

  18. Salud ocupacional del trabajo de estiba: los trabajadores de mercados mayoristas de Huancayo, 2006

    Directory of Open Access Journals (Sweden)

    Liliana Vigil

    2007-10-01

    Full Text Available Objetivo. Conocer las condiciones de higiene y seguridad del proceso de trabajo de estiba y su relación con el estado de salud de los trabajadores que realizan esta actividad. Materiales y métodos. Se realizó un estudio observacional en trabajadores de estiba de papa de los mercados mayoristas de Huancayo, Perú (3350 msnm. Se realizó una valoración antropométrica según parámetros internacionales, se evaluaron las condiciones laborales por observación directa y ergonómicas usando el método REBA y OWAS. Se realizó un examen clínico y traumatológico, y se evaluó la satisfacción laboral y los niveles de ansiedad y depresión con la escala de Zung. Resultados. Se evaluaron 105 trabajadores, 72,4% fueron estibadores, 25,7% cabeceadores y 1,9% transportistas manuales de carga, su estatura promedio fue de 159,9 ± 5,8 cm, manipulan sacos de 150 kg y diariamente pueden movilizar entre 10 a 20 toneladas. Se encontraron posturas inadecuadas como flexión de cuello > 60º, flexión elevada de brazos, flexión de tronco > 60º y flexión de tronco con movimientos de rotación, calificando esta actividad de riesgo ergonómico muy alto. 55% presentaron lumbalgia, 42% hiperxifosis dorsal, 62% refirieron estar satisfechos con su trabajo, no tenían síntomas depresivos 77% y de ansiedad 62%. Conclusiones. El proceso de trabajo de estiba es riesgoso para la salud de los trabajadores, debido al peso extremadamente excesivo que manejan, por lo que se debe reglamentar la reducción del peso de la carga a estándares internacionales (55 kg. Es necesario adoptar medidas, especialmente en lo que concierne a la capacitación de buenas técnicas en el transporte y manejo de carga.

  19. Caracterización de hábitat y abundancia local de Dynastes hercules (Coleoptera: Melolonthidae: Dynastinae en bosques subandinos del departamento de Santander, Colombia

    Directory of Open Access Journals (Sweden)

    Luisa Fernanda Ballesteros Mesa

    2006-01-01

    Full Text Available Se realizó una caracterización del estrato arbóreo de dos bosques subandinos con antecedentes de colecta del escarabajo hércules, Dynastes hercules, para estudiar la  condición de su hábitat y cuantificar la abundancia local. Se identificaron dos tipos de bosques correspondientes a robledal y selva de lauráceas; el estado de conservación del primer tipo de bosque es óptimo, teniendo en cuenta la densidad y buena oferta de árboles, troncos caídos en descomposición, flores y frutos. La abundancia de D. hercules fue mayor en el bosque de lauráceas debido a la baja presión de extracción de escarabajos en comparación con la población del bosque de roble. Por otro lado, los datos de abundancia de adultos obtenidos en el presente estudio no concuerdan con las estimaciones realizadas en trabajos similares.

  20. La teoría del todo (2014, una mirada hacia los efectos de la Esclerosis Lateral Amiotrófica en la vida de Stephen Hawking/ The theory of everything (2014, a closer to the effects of Amiotrophic Lateral Sclerosis in the life of Stephen Hawking

    Directory of Open Access Journals (Sweden)

    Sofia Aguiñaga?Malanco et al.

    2017-03-01

    Full Text Available Stephen Hawking, autor de las teorías más fundamentales sobre el comportamiento de los agujeros negros, entreotras consideraciones sobre el tiempo y el espacio; padece de esclerosis lateral amiotrófica, la cual le fue diagnosticadadurante su último año en Oxford, tal y como se describe en la película La teoría del todo (2014 dirigida porJames Marsh y producida por Anthony McCarten. La esclerosis lateral amiotrófica (ELA o enfermedad de Lou Gehriges una alteración neurodegenerativa progresiva que ocasiona debilitamiento gradual de la musculatura voluntaria.Se caracteriza por una pérdida progresiva de la moto?neurona de la corteza motora, tronco del encéfalo y médulaespinal.

  1. Ruptura da barreira hematoencefálica após injeção de droga gliotóxica no tronco encefálico de ratos wistar

    Directory of Open Access Journals (Sweden)

    Bondan Eduardo Fernandes

    2002-01-01

    Full Text Available O brometo de etídio (BE determina desaparecimento astrocitário local, com ruptura da glia limitans e suposto dano na barreira hematoencefálica (BBB. Este estudo visou avaliar a integridade da BBB após injeção de solução de BE a 0,1% (grupo E ou de salina a 0,9% (grupo C na cisterna pontis de ratos Wistar. Fragmentos do tronco encefálico foram coletados das 24 horas aos 31 dias pós-injeção para estudo ultra-estrutural e marcação imuno-histoquímica para a GFAP. Alguns animais receberam carvão coloidal por via intravenosa nos mesmos períodos. Nos ratos do grupo C, não houve sinal de perda astrocitária, nem extravasamento vascular de carvão no sítio da injeção. No grupo E, o desaparecimento astrocitário começou às 48 horas e algumas áreas estavam ainda destituídas de processos astrocíticos 31 dias após. Extravasamento de partículas de carvão nas lesões foi visto de 48 horas até 7 dias, não sendo detectada qualquer alteração ultra-estrutural das junções oclusivas pela falta de astrócitos perivasculares.

  2. Embodying Investigations of Cerebral Palsy

    DEFF Research Database (Denmark)

    Martiny, Kristian Møller Moltke

    to understand what it means for persons to live with CP and then figure out how we should help them . Based on his method of open - minded cognitive science, Martiny presents data on neuro - physiological, psychological and social aspects of living with CP. From this theoretical work, Martiny develops......The main question of Kristian Martiny’s dissertation is: how do we help persons living with the brain damage, cerebral palsy (CP)? This question is as complex and difficult to answer as any healthcare question. Martiny argues that we need to ‘open up’ how we do ( cognitive ) science in order...... an embodied - based model of intervention for CP, focusing on the experience of self control as a way to help people with CP. In addition, a theatre performance, Humane Liquidation , and a documentary film, Natural Disorder, are developed so as to both communicate what it means to live with CP and empower...

  3. Cerebral hemisphere astrocytoma: Treatment results

    International Nuclear Information System (INIS)

    Boyages, J.; Tiver, K.W.

    1987-01-01

    Eighty two adult patients with histologically proven cerebral astrocytomas of grades I to IV received post-operative radiotherapy at Westmead Hospital between January 1980 and February 1985. Seventy one patients completed a course of megavoltage irradiation, the majority having received a tumour dose of at least 60 Gy. Patients who underwent surgical resection had a greater median survival than those undergoing biopsy, but the difference was not statistically significant. By grade, the difference reached statistical significance only for grade III tumours. Patients with high grade tumours had a significantly lower survival than those patients with tumours of low grade. After adjustment for grade, various dosage levels did not significantly affect survival, although there was a trend towards improved median survival with higher doses in grade III tumours. When included in a multivariate analysis, the extent of surgery did not significantly influence survival, but increasing tumour grade and increasing age were significant adverse prognostic factors. (Auth.)

  4. The serpentine mitral valve and cerebral embolism

    Directory of Open Access Journals (Sweden)

    Ker James

    2011-02-01

    Full Text Available Abstract Valvular strands, well-delineated filiform masses, attached to cardiac valve edges are associated with cerebral embolism and stroke. Strokes, caused by emboli from valvular strands, tend to occur among younger persons. In this case report a valvular strand, giving a peculiar serpentine appearance to the mitral valve is described. This mitral valvular strand was the only explanation for an episode of cerebral embolism, presenting with a transient right sided hemiparesis. It is proposed that a randomized study involving combined treatment with aspirin and clopidogrel is warranted in young patients with valvular strands, presenting with a first episode of cerebral embolism.

  5. Validation of a Cerebral Palsy Register

    DEFF Research Database (Denmark)

    Topp, Monica; Langhoff-Roos, Jens; Uldall, P.

    1997-01-01

    OBJECTIVES: To analyse completeness and validity of data in the Cerebral Palsy Register in Denmark, 1979-1982. METHODS: Completeness has been assessed by comparing data from The Danish National Patient Register (DNPR) with the cases included in the Cerebral Palsy Register (CPR). Agreement between......, but gestational age was subject to a systematic error, and urinary infections in pregnancy (kappa = 0.43) and placental abruption (kappa = 0.52) were seriously under-reported in the CPR. CONCLUSIONS: Completeness of the Cerebral Palsy Register in Denmark, 1979-1982, has been assessed to maximal 85%, emphasizing...

  6. Cerebral palsy in preterm infants

    Directory of Open Access Journals (Sweden)

    Demeši-Drljan Čila

    2016-01-01

    Full Text Available Background/Aim. Cerebral palsy (CP is one of the leading causes of neurological impairment in childhood. Preterm birth is a significant risk factor in the occurrence of CP. Clinical outcomes may include impairment of gross motor function and intellectual abilities, visual impairment and epilepsy. The aim of this study was to examine the relationships among gestational age, type of CP, functional ability and associated conditions. Methods. The sample size was 206 children with CP. The data were obtained from medical records and included gestational age at birth, clinical characteristics of CP and associated conditions. Clinical CP type was determined according to Surveillance of Cerebral Palsy in Europe (SCPE and topographically. Gross motor function abilities were evaluated according to the Gross Motor Function Classification System (GMFCS. Results. More than half of the children with CP were born prematurely (54.4%. Statistically significant difference was noted with respect to the distribution of various clinical types of CP in relation to gestational age (p < 0.001. In the group with spastic bilateral CP type, there is a greater proportion of children born preterm. Statistically significant difference was noted in the functional classification based on GMFCS in terms of gestational age (p = 0.049, children born at earlier gestational age are classified at a higher GMFCS level of functional limitation. The greatest percentage of children (70.0% affected by two or more associated conditions was found in the group that had extremely preterm birth, and that number declined with increasing maturity at birth. Epilepsy was more prevalent in children born at greater gestational age, and this difference in distribution was statistically significant (p = 0.032. Conclusion. The application of antenatal and postnatal protection of preterm children should be a significant component of the CP prevention strategy. [Projekat Ministarstva nauke Republike

  7. Cerebral and non-cerebral coenurosis: on the genotypic and phenotypic diversity of Taenia multiceps.

    Science.gov (United States)

    Christodoulopoulos, Georgios; Dinkel, Anke; Romig, Thomas; Ebi, Dennis; Mackenstedt, Ute; Loos-Frank, Brigitte

    2016-12-01

    We characterised the causative agents of cerebral and non-cerebral coenurosis in livestock by determining the mitochondrial genotypes and morphological phenotypes of 52 Taenia multiceps isolates from a wide geographical range in Europe, Africa, and western Asia. Three studies were conducted: (1) a morphological comparison of the rostellar hooks of cerebral and non-cerebral cysts of sheep and goats, (2) a morphological comparison of adult worms experimentally produced in dogs, and (3) a molecular analysis of three partial mitochondrial genes (nad1, cox1, and 12S rRNA) of the same isolates. No significant morphological or genetic differences were associated with the species of the intermediate host. Adult parasites originating from cerebral and non-cerebral cysts differed morphologically, e.g. the shape of the small hooks and the distribution of the testes in the mature proglottids. The phylogenetic analysis of the mitochondrial haplotypes produced three distinct clusters: one cluster including both cerebral isolates from Greece and non-cerebral isolates from tropical and subtropical countries, and two clusters including cerebral isolates from Greece. The majority of the non-cerebral specimens clustered together but did not form a monophyletic group. No monophyletic groups were observed based on geography, although specimens from the same region tended to cluster. The clustering indicates high intraspecific diversity. The phylogenetic analysis suggests that all variants of T. multiceps can cause cerebral coenurosis in sheep (which may be the ancestral phenotype), and some variants, predominantly from one genetic cluster, acquired the additional capacity to produce non-cerebral forms in goats and more rarely in sheep.

  8. Classification of cerebral palsy: association between gender, age, motor type, topography and Gross Motor Function Classificação da paralisia cerebral: associação entre gênero, idade, tipo motor, topografia e Função Motora Grossa

    Directory of Open Access Journals (Sweden)

    Luzia Iara Pfeifer

    2009-12-01

    Full Text Available The goal of this study was to assess the relation between gender, age, motor type, topography and gross motor function, based on the Gross Motor Function System of children with cerebral palsy. Trunk control, postural changes and gait of one hundred children between 5 months and 12 years old, were evaluated. There were no significant differences between gender and age groups (p=0.887 or between gender and motor type (p=0.731. In relation to body topography most children (88% were spastic quadriplegic. Most hemiplegics children were rated in motor level I, children with diplegia were rated in motor level III, and quadriplegic children were rated in motor level V. Functional classification is necessary to understand the differences in cerebral palsy and to have the best therapeutic planning since it is a complex disease which depends on several factors.Este estudo teve como objetivo avaliar a relação entre gênero, idade, tipo motor, topografia e Função Motora Grossa, baseado no Sistema de Função Motora Grossa em crianças com paralisia cerebral. Participaram desta pesquisa 100 crianças com idade entre 5 meses a 12 anos que foram observadas em relação ao controle de tronco, trocas posturais e marcha. Não houve diferenças significativas entre gêneros e grupos etários (p=0,887 e entre gênero e tipo motor (p=0,731. Em relação à topografia corporal, houve predomínio de crianças com quadriplegia, sendo que a maioria (88% era do tipo espástico. Quanto ao nível motor, as crianças hemiplégicas pertenciam em sua maioria ao nível I, as diplégicas ao nível III e as quadriplégicas ao nível V. Sendo a paralisia cerebral uma condição complexa que depende de diversos fatores, beneficia-se de classificações funcionais para compreensão da diversidade e melhor planejamento terapêutico.

  9. Clinical significance of determination of plasma NPY levels and serum lipid profile in patients with cerebral hemorrhage and cerebral infarction

    International Nuclear Information System (INIS)

    Huang Fujuan; Shen Airong; Yang Yongqing

    2010-01-01

    Objective: To study the clinical significance of changes of plasma NPY levels and serum lipid profile in patients with cerebral hemorrhage and cerebral infarction. Methods: Plasma NPY levels (with RIA) and serum lipid profile (with biochemistry) were determined in (1) 48 patients with acute cerebral hemorrhage (2) 46 patients with acute cerebral infarction and (3) controls.Results Plasma NPY levels in both patients with cerebral hemorrhage and patients with cerebral infarction were significantly higher than those in controls (P 0.05). Conclusion: NPY played important roles in the development and pathogenesis of cerebral vascular accidents. Lipid profile changes was the basic etiological factor. (authors)

  10. Il dono del racconto

    DEFF Research Database (Denmark)

    Polito, Paola

    1998-01-01

    L'articolo indaga a vari livelli strutturali del romanzo "Il coraggio del pettirosso" (rete metaforica, dialogismo diegetico, dialogismo come fenomeno di voce, strategie discorsive messe in atto dalla voce narrante, stile colloquiale) la complessa realizzazione testuale del genere narrativo...

  11. CT classification and clinical prognosis of cerebral infarction in the area of middle cerebral artery

    International Nuclear Information System (INIS)

    Konno, Jyoji

    1983-01-01

    Computerized tomographies (CT) were repeatedly scanned on 70 patients with cerebral infarction in the middle cerebral artery. Low density area (LDA) was measured with HounFsfield's Unit (HU) and studied on the progressive changes. Classification of LDA was attempted and studied on correlation with mass effect, contrast enhancement, angiographical findings, clinical symptoms and prognosis. It was considered that important points of diagnosis of cerebral infarction were timing of examination of CT and determination of LDA with HUF. It was also thought that CT classification of LDA was usefull to estimate prognosis of the patients with cerebral infarction. (author)

  12. Linfoma primario del sistema nervioso central en un paciente inmunocompetente

    Directory of Open Access Journals (Sweden)

    José Málaga-Zenteno

    2012-07-01

    Full Text Available El linfoma primario del sistema nervioso central (LPSNC constituye el 2% de los linfomas extranodales y entre 0,3% y 1,5% de todas las neoplasias intracraneales en pacientes inmunocompetentes, siendo más frecuente a partir de los 60 años. Reportamos el caso de un paciente varón de 76 años, sin antecedentes médicos de importancia, que inició su enfermedad con inestabilidad en la marcha, dificultad para mover el hemicuerpo izquierdo, a predominio braquial, cefalea holocraneal y mareos. Ingresó a emergencia despierto, parcialmente desorientado, Glasgow 14 y ptosis palpebral derecha; además, hemiparesia e hipoestesia izquierda, a predominio crural. Por tomografía computarizada cerebral se evidenció imagen captadora de contraste en región frontoparietal derecha, intra y extra craneal, edema cerebral y desplazamiento de la línea media. Se realizó craneotomía y biopsia del tumor, diagnosticándose linfoma difuso de células grandes B del sistema nervioso central. Fue VIH negativo. Se descartó otro tumor primario y metástasis. Recibió esquema CHOD/BVAM y radioterapia. Evolucionó favorablemente. Según resonancia magnética cerebral postratamiento, desapareció el tumor.

  13. Transplante de células-tronco hematopoéticas em doenças reumáticas. Parte 2: experiência brasileira e perspectivas futuras Hematopoietic stem cell transplantation for rheumatic diseases. Part 2: brazilian experience and future prospectives

    OpenAIRE

    Júlio C. Voltarelli; Ana Beatriz P. L. Stracieri; Maria Carolina B. Oliveira; Dannielle F. Godoi; Daniela A. Moraes; Fabiano Pieroni; Kelen C. R. Malmegrim; Marina A. Coutinho; Belinda P. Simões; Celso Massumoto; Nelson Hamerschlak; Morton Scheinberg; Eurípides Ferreira; Mariana Coutinho; Maurício Ostronoff

    2005-01-01

    Nesta revisão, discutem-se os resultados dos transplantes de células-tronco hematopoéticas (TCTH) para doenças reumáticas graves e refratárias à terapia convencional realizados no Brasil. São analisados os resultados preliminares obtidos no Brasil com o TCTH autólogo em casos esporádicos (N=3) e no protocolo cooperativo iniciado em 2001 (N=18). Neste protocolo, dentre os 8 casos de nefrite lúpica, houve 3 remissões sustentadas, 3 óbitos, 1 falha de mobilização e 1 seguimento ainda muito curto...

  14. Cerebral cysticercosis in a cat : clinical communication

    Directory of Open Access Journals (Sweden)

    E.V. Schwan

    2002-07-01

    Full Text Available The metacestode of Taenia solium, Cysticercus cellulosae, was recovered from the brain of a cat showing central nervous clinical signs ante mortem. This is the first record of cerebral cysticercosis in a cat in South Africa.

  15. CEREBRAL CORTEX DAMAGE INDUCED BY ACUTE ORAL ...

    African Journals Online (AJOL)

    2018-02-28

    Feb 28, 2018 ... This study examines alcohol-induced cerebral cortex damage and the association with oxidative ... alcohol has profound effects on the function ... Chronic use of ..... Alcohol induced brain damage and liver damage in young.

  16. Genetics Home Reference: cerebral folate transport deficiency

    Science.gov (United States)

    ... R. Cerebral folate deficiency syndromes in childhood: clinical, analytical, and etiologic aspects. Arch Neurol. 2011 May;68( ... 2009.08.005. Citation on PubMed or Free article on PubMed Central Toelle SP, Wille D, Schmitt ...

  17. Gluconeogenesis and fasting in cerebral malaria

    NARCIS (Netherlands)

    van Thien, H.; Ackermans, M. T.; Weverling, G. J.; Dang Vinh, T.; Endert, E.; Kager, P. A.; Sauerwein, H. P.

    2004-01-01

    BACKGROUND: In healthy subjects after an overnight fast, glucose production is for approximately 50% derived from glycogenolysis. If the fast is prolonged, glucose production decreases due to a decline in glycogenolysis, while gluconeogenesis remains stable. In cerebral malaria, glucose production

  18. [Functional electric stimulation (FES) in cerebral palsy].

    Science.gov (United States)

    Miyazaki, M H; Lourenção, M I; Ribeiro Sobrinho, J B; Battistella, L R

    1992-01-01

    Our study concerns a patient with cerebral palsy, submitted to conventional occupational therapy and functional electrical stimulation. The results as to manual ability, spasticity, sensibility and synkinesis were satisfactory.

  19. Somatosensory discrimination deficits following pediatric cerebral malaria.

    Science.gov (United States)

    Dugbartey, A T; Spellacy, F J; Dugbartey, M T

    1998-09-01

    Pathologic studies of central nervous system damage in human falciparum malaria indicate primary localization in the cerebral white matter. We report a sensory-perceptual investigation of 20 Ghanaian children with a recent history of cerebral malaria who were age-, gender-, and education-matched with 20 healthy control subjects. Somatosensory examinations failed to show any evidence of hemianesthesia, pseudohemianesthesia, or extinction to double simultaneous tactile stimulation. While unilateral upper limb testing revealed intact unimanual tactile roughness discrimination, bimanual tactile discrimination, however, was significantly impaired in the cerebral malaria group. A strong negative correlation (r = -0.72) between coma duration and the bimanual tactile roughness discrimination test was also found. An inefficiency in the integrity of callosal fibers appear to account for our findings, although alternative subcortical mechanisms known to be involved in information transfer across the cerebral hemispheres may be compromised as well.

  20. Cerebral blood flow: Physiologic and clinical aspects

    International Nuclear Information System (INIS)

    Wood, J.H.

    1987-01-01

    This book contains 46 chapters divided among nine sections. The section titles are: Historical Perspectives; Cerebrovascular Anatomy; Cerebrovascular Physiology; Methods of Clinical Measurement; Experimental Methods; Imaging of Cerebral Circulation; Cerebrovascular Pathophysiology; Cerebrovascular Pharmacology; and Surgical and Interventional Augmentation

  1. Cerebral oxygen desaturation during beach chair position

    NARCIS (Netherlands)

    Moerman, Annelies T.; de Hert, Stefan G.; Jacobs, Tom F.; de Wilde, Lieven F.; Wouters, Patrick F.

    2012-01-01

    Cases of ischaemic brain damage have been reported in relatively healthy patients undergoing shoulder surgery in the beach chair position. Unrecognised cerebral hypoperfusion may have contributed to these catastrophic events, indicating that routine anaesthesia monitoring may not suffice.

  2. Storytelling: Enhancing Vocabularies For Cerebral Palsy Students

    OpenAIRE

    Aprilina, Raita Gina

    2015-01-01

    This paper reported on a study concerned with teaching vocabulary using storytelling technique in one of SLBs in Bandung. This study aimed to find out the cerebral palsy students' ability in English vocabulary before and after the treatment, and to find out whether storytelling significantly improved English vocabulary of students with cerebral palsy. This study used an experimental method with single subject research with A-B-A design which involved two participants. This study revealed that...

  3. Cerebral computerized tomography findings in AIDS patients

    International Nuclear Information System (INIS)

    Hol, P.K.; Dunlop, O.

    1997-01-01

    A cerebral CT was performed in 82 of 525 AIDS patients, with positive findings in 46 cases. These findings included cerebral atrophy in 28 cases, pathological demyelinisation in two, progressive multifocal leukoencephalopathy in one, toxoplasmoses in 11, lymphomas in seven, infarction in one and one subdural haematoma. The radiological findings are correlated to pathology and clinical symptoms. The authors point out the importance of these findings for correct interpretation of the CT scans. 11 refs., 7 figs., 2 tabs

  4. Applications of cerebral MRI in neonatology

    International Nuclear Information System (INIS)

    Prayer, D.

    2000-01-01

    Magnetic resonance tomography (MRT) has become the most important method in the workup of infantile cerebral complications after primary sonography. Cerebral MR examination and image interpretation during the infantile period require extensive knowledge of morphological manifestations, their pathophysiological background, and frequency. The choice of imaging parameters and image interpretation is demonstrated in infarctions and hemorrhages of the mature and immature brain. A review of the main differential diagnoses is also given. The relevance of MR spectroscopy and fetal MRI is discussed. (orig.) [de

  5. Cerebral microcirculation during experimental normovolaemic anaemia

    Directory of Open Access Journals (Sweden)

    Judith eBellapart

    2016-02-01

    Full Text Available Anaemia is accepted amongst critically ill patients as an alternative to elective blood transfusion. This practice has been extrapolated to head injury patients with only one study comparing the effects of mild anaemia on neurological outcome. There are no studies quantifying microcirculation during anaemia. Experimental studies suggest that anaemia leads to cerebral hypoxia and increased rates of infarction, but the lack of clinical equipoise when testing the cerebral effects of transfusion amongst critically injured patients, supports the need of experimental studies. The aim of this study was to quantify cerebral microcirculation and the potential presence of axonal damage in an experimental model exposed to normovolaemic anaemia, with the intention of describing possible limitations within management practices in critically ill patients. Under non-recovered anaesthesia, six Merino sheep were instrumented using an intracardiac transeptal catheter to inject coded microspheres into the left atrium to ensure systemic and non-chaotic distribution. Cytometric analyses quantified cerebral microcirculation at specific regions of the brain. Amyloid precursor protein staining was used as an indicator of axonal damage. Animals were exposed to normovolaemic anaemia by blood extractions from the indwelling arterial catheter with simultaneous fluid replacement through a venous central catheter. Simultaneous data recording from cerebral tissue oxygenation, intracranial pressure and cardiac output was monitored. A regression model was used to examine the effects of anaemia on microcirculation with a mixed model to control for repeated measures. Homogeneous and normal cerebral microcirculation with no evidence of axonal damage was present in all cerebral regions, with no temporal variability, concluding that acute normovolaemic anaemia does not result in short term effects on cerebral microcirculation in the ovine brain.

  6. Hyperdense lesions in CT of cerebral toxoplasmosis

    International Nuclear Information System (INIS)

    Quinones Tapia, D.; Ramos Amador, A.; Monereo Alonso, A.

    1994-01-01

    We report a case of cerebral toxoplasmosis in a patient with stage IV C 1 AIDS who presented hyperdense CT images 13 days after beginning antitoxoplasma treatment. These lesions could be caused by calcifications or blood. The attenuation values lead us to believe that they are calcium. Intracranial calcification in adult cerebral toxoplasmosis is an uncommon finding. Its presence in AIDS patients should not suggest any etiology other than toxoplasmosis. (Author) 16 refs

  7. Relevamiento de vectores de la Enfermedad de Chagas en peridomicilios del área rural del Departamento Ayacucho, San Luis, Argentina

    Directory of Open Access Journals (Sweden)

    Diego I. CHARTIER

    2007-01-01

    Full Text Available Debido a la importancia de las poblaciones peridomésticas en los procesos de reinfestación de las viviendas, el objetivo de este trabajo fue evaluar la presencia de triatominos en peridomicilios de la comuna de San Francisco del Monte de Oro, Dpto. Ayacucho, San Luis, Argentina. Se evaluó la presencia de triatominos en 18 peridomicilios entre los meses de Octubre a Marzo (2003/2004, para cada anexo se analizó: tipo de construcción, hospedador y número de triatominos. Los triatominos capturados fueron determinados taxonómicamente y se analizó su infectividad. El 98,3 % de los triatominos pertenecieron a la especie Triatoma infestans (Klug. El 79,3 % de los anexos evaluados fueron positivos. Los índices de infestación para corrales y gallineros fueron de 94,4? % y 54,5? %, respectivamente. No se encontraron insectos infectados con Trypanosoma cruzi (Chagas. Los corrales se diferenciaron en: pirca, empalizada y troncos apilados horizontalmente. En cuanto al número de triatominos, sólo se halló diferencia significativa entre los corrales de pirca y empalizada, siendo el primero mayor (p< 0,05. Los corrales de pirca parecen ser los más aptos para refugios de los triatominos, probablemente debido a la gran cantidad de espacios vacíos que ofrece y a una mayor dificultad para el control químico.

  8. Purine Metabolism in Acute Cerebral Ischemia

    Directory of Open Access Journals (Sweden)

    Ye. V. Oreshnikov

    2008-01-01

    Full Text Available Objective: to study the specific features of purine metabolism in clinically significant acute cerebral ischemia. Subjects and materials. Three hundred and fifty patients with the acutest cerebral ischemic stroke were examined. The parameters of gas and electrolyte composition, acid-base balance, the levels of malonic dialdehyde, adenine, guanine, hypox-anthine, xanthine, and uric acid, and the activity of xanthine oxidase were determined in arterial and venous bloods and spinal fluid. Results. In ischemic stroke, hyperuricemia reflects the severity of cerebral metabolic disturbances, hemodynamic instability, hypercoagulation susceptiility, and the extent of neurological deficit. In ischemic stroke, hyperuri-corachia is accompanied by the higher spinal fluid levels of adenine, guanine, hypoxanthine, and xanthine and it is an indirect indicator of respiratory disorders of central genesis, systemic acidosis, hypercoagulation susceptibility, free radical oxidation activation, the intensity of a stressor response to cerebral ischemia, cerebral metabolic disturbances, the depth of reduced consciousness, and the severity of neurological deficit. Conclusion. The high venous blood activity of xanthine oxidase in ischemic stroke is associated with the better neurological parameters in all follow-up periods, the better early functional outcome, and lower mortality rates. Key words: hyperuricemia, stroke, xanthine oxidase, uric acid, cerebral ischemia.

  9. CT findings of early acute cerebral infarction

    International Nuclear Information System (INIS)

    Kim, Tae Hoon; Choi, Woo Suk; Ryu, Kyung Nam

    1992-01-01

    The CT findings of the acute cerebral infarction are well known. However the CT findings of early stroke within 24 hours of the onset have not been sufficiently reported. The purpose of this study is to evaluate early acute cerebral infarction on CT within 24 hours after ictus. The early and accurate CT diagnosis could lead to the appropriate therapy and improved outcome of the patients. Authors retrospectively analyzed 16 patients with early acute cerebral infarction. Acute cerebral infarction was confirmed by follow-up CT in 11 patients, SPECT in 4 patients, and MRI in 1 patient. The CT findings of early acute cerebral infarction include effacement of cortical sulci or cistern (n = 16, 100%), hyperattenuation of MCA (n = 3), obscuration of lentiform nucleus (n = 6), loss of insular ribbon (n = 6) and subtle low density in hemisphere (n = 5). The most frequent finding was effacement of cortical sulci in our study, and it was thought to be the most important sign of early acute cerebral infarction

  10. CT findings of early acute cerebral infarction

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Tae Hoon; Choi, Woo Suk; Ryu, Kyung Nam [Kyung Hee University Hospital, Seoul (Korea, Republic of)

    1992-11-15

    The CT findings of the acute cerebral infarction are well known. However the CT findings of early stroke within 24 hours of the onset have not been sufficiently reported. The purpose of this study is to evaluate early acute cerebral infarction on CT within 24 hours after ictus. The early and accurate CT diagnosis could lead to the appropriate therapy and improved outcome of the patients. Authors retrospectively analyzed 16 patients with early acute cerebral infarction. Acute cerebral infarction was confirmed by follow-up CT in 11 patients, SPECT in 4 patients, and MRI in 1 patient. The CT findings of early acute cerebral infarction include effacement of cortical sulci or cistern (n = 16, 100%), hyperattenuation of MCA (n = 3), obscuration of lentiform nucleus (n = 6), loss of insular ribbon (n = 6) and subtle low density in hemisphere (n = 5). The most frequent finding was effacement of cortical sulci in our study, and it was thought to be the most important sign of early acute cerebral infarction.

  11. Serial neuroradiological studies in focal cerebritis

    International Nuclear Information System (INIS)

    Hatta, S.; Mochizuki, H.; Kuru, Y.; Miwa, H.; Kondo, T.; Mori, H.; Mizuno, Y.

    1994-01-01

    We report serial neuroradiological studies in a patient with focal cerebritis in the head of the left caudate nucleus. On the day after the onset of symptoms, CT showed an ill-defined low density lesion. The lack of contrast enhancement appeared to be the most important finding for differentiating focal cerebritis from an encapsulated brain abscess or a tumour. MRI two days later revealed the centre of the lesion to be of slightly low intensity on T1-weighted inversion recovery (IR) images and very low intensity on T2-weighted spin echo images, which appeared to correspond to the early cerebritis stage of experimentally induced cerebritis and brain abscess. Ten days after the onset of symptoms, CT revealed a thin ring of enhancement in the head of the caudate nucleus, and a similar small ring was seen in the hypothalamus 16 days after the onset, corresponding to the late cerebritis stage. MRI nine days later revealed ill-defined high signal lesions within the involved area on the T1-weighted IR images. To our knowledge, this is the first published MRI documentation of the early cerebritis stage developing into an encapsulated brain abscess. The mechanisms underlying of these radiographic changes are discussed. (orig.)

  12. Is fasting necessary for elective cerebral angiography?

    Science.gov (United States)

    Kwon, O-K; Oh, C W; Park, H; Bang, J S; Bae, H-J; Han, M K; Park, S-H; Han, M H; Kang, H-S; Park, S-K; Whang, G; Kim, B-C; Jin, S-C

    2011-05-01

    In order to prevent unexpected events such as aspiration pneumonia, cerebral angiography has been performed under fasting in most cases. We investigated prospectively the necessity of fasting before elective cerebral angiography. The study is an open-labeled clinical trial without random allocation. In total, 2554 patients who underwent elective cerebral angiography were evaluated on development of nausea, vomiting, and pulmonary aspiration during and after angiography. Potential risks and benefits associated with fasting were provided in written documents and through personal counseling to patients before the procedure. The patients chose their fasting or nonfasting option. No restriction in diet was given after angiography. The patients were observed for 24 hours. Nausea and vomiting during and within 1 hour after angiography was considered as a positive event associated with cerebral angiography. The overall incidence of nausea and vomiting during and within 1 hour after angiography was 1.05% (27/2554 patients). There was no patient with pulmonary aspiration. No statistical difference in nausea and vomiting development between the fasting and the diet groups was found. The incidence of nausea and vomiting associated with cerebral angiography is low and not affected by diet or fasting. Pulmonary aspiration had no difference between the diet and the fasting group. Our study suggests that fasting may not be necessary for patients who undergo elective cerebral angiography.

  13. Métodos para la evaluación motora objetiva de pacientes con daño cerebral adquirido en neurorrehabilitación funcional

    OpenAIRE

    Villán Villán, Mailin Adriana

    2018-01-01

    El Daño Cerebral Adquirido (DCA) es una alteración de la actividad neuronal en áreas del cerebro que ocurre después del nacimiento. Las secuelas tras un episodio de DCA pueden ser motoras, cognitivas, sociales, entre otras, que pueden transformar la vida de los pacientes en los ámbitos educativo, laboral y familiar. Las causas del DCA pueden ser traumáticas y no traumáticas, siendo las más comunes el Accidente Cerebrovascular (ACV) o Ictus y el Traumatismo Craneoencefálico (TCE). El ACV es la...

  14. Cranio-cerebral gunshot wounds

    Directory of Open Access Journals (Sweden)

    C. Majer1, G. Iacob2

    2010-11-01

    Full Text Available Cranio-cerebral gunshots wounds(CCGW are the most devastating injuriesto the central nervous system, especiallymade by high velocity bullets, the mostdevastating, severe and usually fatal type ofmissile injury to the head.Objective: To investigate and compare,using a retrospective study on five cases theclinical outcomes of CCGW. Predictors ofpoor outcome were: older age, delayedmode of transportation, low admissionCGS score with haemodynamic instability,CT visualization of diffuse brain damage,bihemispheric, multilobar injuries withlateral and midline sagittal planestrajectories made by penetrating highvelocity bullets fired from a very closerange, brain stem and ventricular injurywith intraventricular and/or subarachnoidhemorrhage, mass effect and midline shift,evidence of herniation and/or hematomas,high ICP and/or hypotension, abnormalcoagulation states on admission ordisseminated intravascular coagulation. Lessharmful effects were generated by retainedmissiles, bone fragments with CNSinfection, DAI lesions and neuronaldamages associated to cavitation, seizures.Material and methods: 5 patients (4 maleand 1 female, age ranged 22-65 years, withCCGW, during the period 2004-2009,caused by military conflict and accidentalfiring. After initial resuscitation all patientswere assessed on admission by the GlasgowComa Scale (GCS. After investigations: Xrayskull, brain CT, Angio-CT, cerebralMRI, SPECT; baseline investigations,neurological, haemodynamic andcoagulability status all patients underwentsurgical treatment following emergencyintervention. The survival, mortality andfunctional outcome were evaluated byGlasgow Outcome Scale (GOS score.Results: Referring on five cases weevaluate on a retrospective study the clinicaloutcome, imagistics, microscopic studies onneuronal and axonal damage generated bytemporary cavitation along the cerebralbullet’s track, therapeutics, as the review ofthe literature. Two patients with anadmission CGS 9 and 10

  15. del cambio

    Directory of Open Access Journals (Sweden)

    Alejandro Canales

    2006-01-01

    Full Text Available El artículo analiza las propuestas y los compromisos en materia de cobertura y de financiamiento en el periodo 2000-2006. En particular, revisa las modificaciones y los ajustes de los tres principales documentos en los que se expresaron las iniciativas: el de la Asociación Nacional de Universidades e Instituciones de Educación Superior, el del equipo de la transición y el programa sectorial. Los resultados muestran que las cifras de atención a la demanda educativa e inversión quedaron lejos de las metas autoimpuestas por el gobierno federal y que será necesario realizar mayores esfuerzos para atender tales desafíos.

  16. The Effectiveness of four Motor Games for the Abdominal Conditioning Eficacia de cuatro juegos motores para el acondicionamiento de los músculos del abdomen

    Directory of Open Access Journals (Sweden)

    B. Flores

    2010-09-01

    Full Text Available

    The purpose of this study was to determine the effectiveness of four traditional motor games (“the tunnel”, “the chicken battle”, “the drunk” and “the wheelbarrow race” for strengthening the abdominal muscles. Electromyography (EMG was collected from rectus abdominis (RA, external oblique (EO, and internal oblique (IO from twelve healthy volunteers during the performance of the games and the trunk curl-up exercise. The EMG amplitude was averaged and normalized using maximal voluntary isometric contractions. A two-way ANOVA (muscle / task was used to compare the level of contraction activity and the way the abdominal muscles co-activated during the different tasks. For EO and IO, the EMG amplitudes during the games were equal or greater than the EMG amplitudes of the curl up. The wheelbarrow race produced the highest intensity of contraction for all muscles. The curl up principally activated RA and IO. On the other hand, the games activated the oblique muscles with higher intensity than RA. On the basis of these results, the motor games are effective for abdominal conditioning.
    KEY WORDS: motor games, exercises, training, abdominal muscles, electromyography.

     

    El objetivo de este estudio fue determinar la eficacia de cuatro juegos motores (“el túnel”, “la pelea de gallinas”, “el tentetieso” y “la carretilla” para el fortalecimiento de los músculos del abdomen. Para ello, se registró la electromiografía de los músculos rectus (RA, obliquus externus (OE y obliquus internus abdominis (OI de 12 voluntarios sanos durante la ejecución de los juegos y del ejercicio de encorvamiento del tronco. La amplitud electromiográfica fue promediada y normalizada respecto a la contracción voluntaria isométrica máxima. Posteriormente, se realizó un ANOVA de dos factores (músculo / tarea para comparar la intensidad de la activación muscular y

  17. Valoración de la disposición sagital del raquis en gimnastas especialistas en trampolín. (Assessment of the sagittal plane of the spine in trampoline gymnasts.)

    OpenAIRE

    Pilar Sainz de Baranda; Fernando Santonja Medina; María Rodríguez-Iniesta

    2009-01-01

    ResumenSe valoró la disposición sagital de la columna vertebral en gimnastas especialistas en la modalidad de trampolín. Se realizó un estudio transversal, en el que participaron 69 gimnastas de trampolín (35 mujeres y 34 varones) con una edad media de 14.97 + 4.77 años, y de 6.61+4 años de entrenamiento. La valoración se realizó en tres posiciones: bipedestación relajada, sedentación relajada y flexión máxima del tronco. En todas las posiciones se diferenció la curva dorsal y la lumbar. Para...

  18. VOCES EN EL BOSQUE: EL USO DE RECURSOS VEGETALES ENTRE CAZADORES-RECOLECTORES DE LA ZONA CENTRAL DE TIERRA DEL FUEGO

    Directory of Open Access Journals (Sweden)

    Laura Caruso

    2008-01-01

    Full Text Available Se estudiaron las modalidades de aprovechamiento de las plantas entre los Selknam de Tierra del Fuego (Argentina y se presentan aquí los resultados obtenidos a partir del análisis de los restos de madera carbonizada y sin carbonizar del sitito Ewan, ocupado a principios del siglo XX para la realización de un ritual de iniciación. Los resultados permitieron una mejor comprensión de las estrategias de aprovechamiento de las plantas entre las sociedades cazadoras-recolectoras. La identificación de las especies empleadas y el registro de las principales características morfométricas permitió documentar el aprovechamiento del "ñire" (Nothofagus antarctica. Esta especie, dominante en el entorno, fue utilizada para la construcción de la vivienda y como combustible. En ambos casos se seleccionaron troncos de forma y tamaño adecuados. Los resultados del trabajo arqueobotánico y su confrontación con los datos etnográficos evidenciaron la importancia de los recursos vegetales dentro de la dinámica socioeconómica de este grupo humano. Los recursos vegetales, más allá de su rol alimentario, fueron relevantes en otros aspectos tales como la tecnología, la construcción, el combustible y debieron constituir una ventaja considerable en el ámbito de los bosques de la zona central de Tierra del Fuego.

  19. Valor del electroencefalograma en la asfixia perinatal

    Directory of Open Access Journals (Sweden)

    Desiderio Pozo Lauzán

    1995-04-01

    Full Text Available La obtención de un electroencefalograma en neonatos con asfixia permitió la detección de elementos subclínicos (eléctricos que reflejan disfunción cerebral o no. El registro simultáneo del electroencefalograma, con otros parámetros (respiración, electromiograma de los músculos del mentón, motilidad ocular y corporal y electrocardiogramas, constituye lo que se denomina un registro poligráfico. Con este método fue posible identificar los diferentes estadios del ciclo vigilia-sueño (activo, tranquilo y las etapas transicionales lo cual es fundamental para la categorización de los trazados normales y con anomalías. Se relacionaron diferentes hallazgos del electroencefalograma con el grado de asfixia y con la evolución de los pacientes (a largo plazo. Dichos resultados dieron respuesta a problemas de salud y de atención a los recién nacidos con asfixia y contribuyeron al tratamiento más adecuado a éstos al identificar elementos de disfunción encefálica y también en lo que se relaciona con criterios pronósticos.

  20. Avaliação do desempenho motor em indivíduos com paralisia cerebral após hipoterapia - doi: 10.5102/ucs.v10i2.1734

    Directory of Open Access Journals (Sweden)

    Marianne Lucena

    2012-12-01

    Full Text Available Este estudo teve como objetivo comparar escores de desempenho motor, antes e após sessões de hipoterapia através da escala de Medida da Função Motora Grossa (GMFM. Como método, foi realizado um estudo quantitativo descritivo de intervenção do tipo antes e depois, com 3 casos de paralisia cerebral (PC,de ambos os sexos, com idades entre 5 e 7 anos, escolhidos de forma não probabilista, com quadro motor de quadriplegia mista. Foi obtida, como resultado, FAB, RFC e BES apresentaram melhora de 88.35%, 96% e 31%, respectivamente na dimensão A deitar e rola e 16.65%, 31.66% e 33% na dimensão B: sentar. RFC e BES também apresentaram melhoras na dimensão C: engatinhar e ajoelhar de 2.38% e 40.47%, respectivamente. Este estudo conclui que indivíduos com PC melhoram controle de tronco e cervical, sendo que com os índices da escala GMFM foi possível quantificar os ganhos motores.

  1. Cerebral blood measurements in cerebral vascular disease: methodological and clinical aspects

    International Nuclear Information System (INIS)

    Fieschi, C.; Lenzi, G.L.

    1982-01-01

    This paper is devoted mainly to studies performed on acute cerebral vascular disease with the invasive techniques for the measurement of regional cerebral blood flow (rCBF). The principles of the rCBF method are outlined and the following techniques are described in detail: xenon-133 inhalation method, xenon-133 intravenous method and emission tomography methods. (C.F.)

  2. The early markers for later dyskinetic cerebral palsy are different from those for spastic cerebral palsy

    NARCIS (Netherlands)

    Einspieler, C; Cioni, G; Paolicelli, PB; Bos, AF; Dressler, A; Ferrari, F; Roversi, MF; Prechtl, HFR

    Qualitative abnormalities of spontaneous motor activity in new-borns and young infants are early predictive markers for later spastic cerebral palsy. Aim of this research was to identify which motor patterns may be specific for later dyskinetic cerebral palsy. In a large, prospectively performed

  3. Development and face validity of a cerebral visual impairment motor questionnaire for children with cerebral palsy

    NARCIS (Netherlands)

    Salavati, Masoud; Waninge, Aly; Rameckers, E.A.A.; van der Steen, J; Krijnen, W.P.; van der Schans, C.P.; Steenbergen, B.

    2016-01-01

    AIM: The objectives of this study were (i) to develop two cerebral visual impairment motor questionnaires (CVI-MQ's) for children with cerebral palsy (CP): one for children with Gross Motor Function Classification System (GMFCS) levels I, II and III and one for children with GMFCS levels IV and V;

  4. Low cerebral blood flow after cardiac arrest is not associated with anaerobic cerebral metabolism

    NARCIS (Netherlands)

    Hoedemaekers, C.W.E.; Ainslie, Philip N.; Hinssen, S.; Aries, M.J.; Bisschops, Laurens L.; Hofmeijer, Jeannette; van der Hoeven, J.G.

    2017-01-01

    Aim of the study Estimation of cerebral anaerobic metabolism in survivors and non-survivors after cardiac arrest. Methods We performed an observational study in twenty comatose patients after cardiac arrest and 19 healthy control subjects. We measured mean flow velocity in the middle cerebral artery

  5. A clinical study of cerebral vaso paralysis during a period of cerebral vasospasm after subarachnoid hemorrhage

    International Nuclear Information System (INIS)

    Watanabe, Toshiichi; Sasaki, Takehiko; Nakagawara, Jyoji

    2011-01-01

    We employ the 123 I-infinitum (Imp) single photon emission computed tomography (SPECT) dual table autoradiography (Arg) method and stereotactic extraction estimation (SEE) analysis 7 or 8 days after subarachnoid hemorrhage (SAH) onset to predict cerebral vasospasm. We report new findings of cerebral vasoparalysis during a period of cerebral vasospasm after SAH. From January 1, 2005 to April 30, 2008, we encountered 330 cases of aneurysmal SAH, and treated 285 cases. Of these, 65 were excluded as unsuitable for this study, for reasons such as lack of SPECT data, external decompression, admission over 7 days from SAH onset. We studied 220 cases treated by microsurgical clipping (n=178) or endovascular coil embolization (n=42). Vasoparalysis was defined as a rise in resting cerebral blood flow (CBF) and a loss of vascular reserve on SEE analysis of CBF-SPECT. Vasoparalysis occurred in 15 cases (6.8%). Of these, 9 cases (60.0%) had cerebral hematoma, temporary clips had been used in the operation for 8 cases (53.3%), 9 cases (60.0%) experienced postoperative cerebral infarction, and 3 cases (20.0%) had postoperative convulsions. Vasoparalysis occurs in relation to perioperative cerebral damage. In terms of the loss of vascular reserve following SAH, vasoparalysis resembles hemodynamic cerebral ischemia, although the conditions are quite different. Differentiating between these 2 conditions is important, as different forms of management are required. Dual table ARG and SEE analysis are very useful for the evaluating these 2 conditions. (author)

  6. Development and face validity of a cerebral visual impairment motor questionnaire for children with cerebral palsy

    NARCIS (Netherlands)

    Salavati, M.; Waninge, A.; Rameckers, E. A. A.; van der Steen, J.; Krijnen, W. P.; van der Schans, C. P.; Steenbergen, B.

    Aim The objectives of this study were (i) to develop two cerebral visual impairment motor questionnaires (CVI-MQ's) for children with cerebral palsy (CP): one for children with Gross Motor Function Classification System (GMFCS) levels I, II and III and one for children with GMFCS levels IV and V;

  7. Cerebral CT of ischaemic lesions

    Energy Technology Data Exchange (ETDEWEB)

    Aulich, A

    1981-11-25

    The diagnosis of stroke must first be established by clinical examination. CT has proved useful for confirmation of the diagnosis and provides a global intracranial picture of morphological changes in cerebral vascular diseases. A hemorrhage can be recognized with certainty at the first CT examination as the cause of the stroke, but in the detection of a lesion due to ischemia an important role is played by the correct choice of the time of examination, and in some cases also of the check-up with contrast medium. The differential diagnosis between infarct in the acute stage and encephalitis or gliomas of low-grade malignity can be difficult. A decision can often only be made after a series of examinations. Postmalacial conditions are often difficult to differentiate from defects due to other causes, such as hemorrhage, head injury, postoperative states and after encephalitis. A knowledge of the anamnesis and the clinical findings is indispensable for CT evaluation. In assessing the prognosis before vascular surgery on the extracranial brain-supplying vessels the performance of a CT examination should be advised. A warning is given against the use of CT as a screening method.

  8. Cerebral sino-venous thrombosis

    International Nuclear Information System (INIS)

    Sayama, Ichiro; Kobayashi, Tsunesaburo; Nakajima, Kenji

    1982-01-01

    Three cases of cerebral sino-venous thrombosis were reported. Repeated CT findings were studied and discussed on account of the treatments for those pathologic conditions. Those of studied cases are; a 22-year-old postpartum woman, a 42-year-old woman with irregular vaginal bleeding, and a 26-year-old man with severe reactive emesis after drinking alcohol. They were treated conservatively. Case 1 died in its acute stage. In the remaining ones, each had an uneventful recovery. CT scan findings of them manifested their exact clinical conditions. These findings were devided into two categories, one was direct signs expressed sino-venous occlusion, the other was indirect signs which appeared as a result of these occlusion. Direct signs cannot always get in every cases with sino-venous occlusion, but as for indirect signs, we can get various changes corresponding to the time taken CT photoes, and they are useful to decide appropriate treatments at that time. Considering suitable treatments for this disease, it is necessary to select most suitable ones according to their pathologic conditions, which may be precisely drawn with CT scans. (J.P.N.)

  9. Cerebral oxygen metabolism and cerebral blood flow in man during light sleep (stage 2)

    DEFF Research Database (Denmark)

    Madsen, P L; Schmidt, J F; Holm, S

    1991-01-01

    We measured cerebral blood flow (CBF) and cerebral metabolic rate of oxygen (CMRO2) during light sleep (stage 2) in 8 young healthy volunteers using the Kety-Schmidt technique with 133Xe as the inert gas. Measurements were performed during wakefulness and light sleep as verified by standard...... polysomnography. Unlike our previous study in man showing a highly significant 25% decrease in CMRO2 during deep sleep (stage 3-4) we found a modest but statistically significant decrease of 5% in CMRO2 during stage 2 sleep. Deep and light sleep are both characterized by an almost complete lack of mental activity....... They differ in respect of arousal threshold as a stronger stimulus is required to awaken a subject from deep sleep as compared to light sleep. Our results suggest that during non-rapid eye movement sleep cerebral metabolism and thereby cerebral synaptic activity is correlated to cerebral readiness rather than...

  10. Listeriosis cerebral en el modelo murino : patogénesis y prevención

    OpenAIRE

    Frande Cabanes, Elisabet

    2017-01-01

    RESUMEN: La microglía, células inmunes innatas del cerebro, juega un papel central en la listeriosis cerebral. En este trabajo se muestra como la microglía controla la infección por Listeria de manera diferente que los macrófagos. La infección de cultivos primarios microgliales y de líneas celulares murinas con Listeria dio lugar a dos patrones de expresión de genes implicados en la respuesta inmune en macrófagos. Mientras que el gen bacteriano hly parece ser responsable de ambos patrones tra...

  11. Estrategias educativas para alumnos con daño cerebral sobrevenido

    OpenAIRE

    Grau Rubio, Claudia

    2007-01-01

    Los síntomas de los niños afectados por un daño cerebral sobrevenido pueden ser pasajeros o permanentes, y presentar alteraciones cognitivas (percepción, atención, memoria y pensamiento), expresivas (lenguaje y motricidad), emocionales y del comportamiento y alteración en las funciones ejecutivas. Asimismo, pueden sufrir ataques de epilepsia, hidrocefalia, cefalea y fatiga crónica y tienen problemas de aprendizaje, de conducta y de adaptación social. La escuela debe hacer las adaptaciones ...

  12. Cerebral asymmetry in a selected Chinese population

    International Nuclear Information System (INIS)

    Wang, Y.X.; He, G.X.; Tong, G.H.; Wang, D.B.; Xu, K.Y.

    1999-01-01

    Previous studies have demonstrated anatomical differences between the two cerebral hemispheres and ethnic differences in cerebral asymmetry. This study examined asymmetry of Chinese living in Shanghai. Measurements were taken across the frontal, mid-cerebral and occipital regions from normal head computed tomography (CT) scans of 200 Chinese Shanghai residents (100 male and 100 female, aged 6-73 years, average 48.7 years). The results were compared with reported data in the literature. The following results were found: (i) In the frontal region the right side was larger than the left in 57.5% of cases, equal in 10.5% and smaller in 32% of cases; in the mid-cerebral region the right side was larger than the left in 65.5% of cases, equal in 12.5% and smaller in 22% of cases; in the occipital regions the right side was larger than the left in 34.5% of cases, equal in 8.5% and smaller in 57% of cases. The average right-left differences between the frontal, mid-cerebral and occipital regions were 0.43 mm, 0.9 mm and 0.4 mm respectively. No difference in cerebral asymmetry existed between males and females. The occipital lobes showed the greatest individual asymmetry. The distribution of cerebral asymmetry of Chinese in Shanghai showed similarity to North American Whites rather than North American Blacks, but the average right-left differences were smaller than those of Whites. Copyright (1999) Blackwell Science Pty Ltd

  13. Association of Lead Levels and Cerebral Palsy

    Directory of Open Access Journals (Sweden)

    Neha Bansal MD

    2017-03-01

    Full Text Available Background: Cerebral palsy is a common motor disability in childhood. Raised lead levels affect cognition. Children with cerebral palsy may have raised lead levels, further impairing their residual cognitive motor and behavioral abilities. Environmental exposure and abnormal eating habits may lead to increased lead levels. Aims and Objectives: To measure blood lead levels in children with cerebral palsy and compare them with healthy neurologically normal children. To correlate blood lead levels with environmental factors. Material and Methods: Design: Prospective case-control study. Setting: Tertiary care hospital. Participants: Cases comprised 34 children with cerebral palsy, and controls comprised 34 neurologically normal, age- and sex-matched children. Methods: Clinical and demographic details were recorded as per proforma. Detailed environmental history was recorded to know the source of exposure to lead. These children were investigated and treated as per protocol. Venous blood was collected in ethylenediaminetetraacetic acid vials for analysis of blood lead levels. Lead levels were estimated by Schimadzu Flame AA-6800 (atomic absorption spectrophotometer. Data were analyzed using SPSS version 17. P < .05 was taken as significant. Results: Mean blood lead levels were 9.20 ± 8.31 µg/dL in cerebral palsy cases and 2.89 ± 3.04 µg/dL in their controls (P < .001. Among children with cerebral palsy, 19 (55.88% children had blood lead levels ≥5 µg/dL. Lead levels in children with pica were 12.33 ± 10.02 µg/dL in comparison to children with no history of pica, 6.70 ± 4.60 µg/dL (P = .029. No correlation was found between hemoglobin and blood lead levels in cases and controls. Conclusion: In our study, blood lead levels are raised in children with cerebral palsy. However, further studies are required to show effects of raised levels in these children.

  14. Tricholeiperia peruensis n. sp. (Nematoda, Molineidae del quiróptero Lophostoma silvicolum occidentalis (Phyllostomidae en Tumbes, Perú

    Directory of Open Access Journals (Sweden)

    Marina Vargas

    2008-12-01

    Full Text Available En el presente trabajo, se describe a Tricholeiperia peruensis n. sp. (Nematoda, Molineidae en base a 25 especímenes colectados del intestino de 5 murciélagos de la especie Lophostoma silvicolum occidentalis de la localidad de Angostura, distrito Pampas de Hospital, departamento de Tumbes, Perú. La nueva especie se caracteriza por la morfología de la vesícula cefálica en forma de capuchón con escotaduras, por el tamaño y forma de las espículas cuyo extremo distal de la rama externa se divide en dos, de las cuales la rama interna sufre una nueva división; por la disposición de las costillas de la bolsa copulatríz donde, entre otros detalles, las antero y postero-ventrales están separadas y las externo-dorsales nacen cerca de la parte media del tronco dorsal y son gruesas.

  15. Endotoxemia reduces cerebral perfusion but enhances dynamic cerebrovascular autoregulation at reduced arterial carbon dioxide tension*

    DEFF Research Database (Denmark)

    Brassard, Patrice; Kim, Yu-Sok; van Lieshout, Johannes

    2012-01-01

    OBJECTIVE:: The administration of endotoxin to healthy humans reduces cerebral blood flow but its influence on dynamic cerebral autoregulation remains unknown. We considered that a reduction in arterial carbon dioxide tension would attenuate cerebral perfusion and improve dynamic cerebral autoreg...

  16. Avaliações clínica, ecográfica e anatomofisiológica do alotransplante parcial de vesícula urinária com células-tronco mesenquimais alogênicas derivadas do tecido adiposo em coelhos

    Directory of Open Access Journals (Sweden)

    S. T. L. Pinto Filho

    2015-10-01

    Full Text Available RESUMOOs problemas relacionados ao armazenamento vesical são muitos e relevantes. Eles, além de influírem de forma efetiva na qualidade de vida, podem eventualmente evoluir para falência renal. Existem vários trabalhos, os quais descrevem as propriedades imunomoduladoras e imunossupressoras das células-tronco mesenquimais derivadas do tecido adiposo (ADSCs. Objetiva-se com o presente avaliar clínica, ecográfica e anatomofisiologicamente o alotransplante parcial de bexiga a fresco em coelhos, utilizando como agente imunomodulador ADSCs alogênicas. Para isso foram utilizados 25 coelhos, sendo um deles macho e doador das ADSCs, e os outros 24 eram fêmeas, submetidas a alotransplante parcial de bexiga, sendo tratadas com ciclosporina (GCi ou células-tronco mesenquimais (GCe. Conclui-se que as ADSCs foram suficientes para evitar sinais clínicos e ecográficos de rejeição ao alotransplante de vesícula urinária, mantendo a estrutura anatomofisiológica vesical por até 30 dias em coelhos.

  17. La superaci??n del modelo del ??ngel del hogar:

    OpenAIRE

    Hurtado Mu??oz, M??nica

    2012-01-01

    La Tesis Doctoral titulada "La superaci??n del modelo del "??ngel del hogar". Recuperaci??n de la escritora Leonor Canalejas y Fustegueras (1869-1945)" aborda, en primer lugar, un an??lisis sociol??gico de las circunstancias que rodearon a la mujer espa??ola en el cambio de siglo en el ??mbito social y educativo, en un intento de esclarecer las caracter??sticas propias del contexto en el que la mujer accede a la intelectualidad en general y a la literatura en particular. Esta parte concluye q...

  18. Anemia aplásica adquirida e anemia de Fanconi - Diretrizes Brasileiras em Transplante de Células-Tronco Hematopoéticas Acquired aplastic anemia and Fanconi anemia - Brazilian Guidelines in Hematopoietic Stem Cell Transplantation

    Directory of Open Access Journals (Sweden)

    Larissa A. Medeiros

    2010-05-01

    Full Text Available As diretrizes apresentadas neste trabalho foram elaboradas e aprovadas na I Reunião de Diretrizes Brasileiras em Transplante de Células-Tronco Hematopoéticas (TCTH realizada no Rio de Janeiro, entre os dias 19 e 21 de julho de 2009. O evento foi promovido pela SBTMO (Sociedade Brasileira de Transplante de Medula Óssea. Neste artigo, tratamos da anemia aplásica severa (AAS, considerada uma urgência hematológica, que, identificada e manejada de forma precoce, apresenta grande possibilidade de recuperação da hematopoese seja através de transplante de medula óssea ou terapia imunossupressora. Objetiva-se nortear o manejo terapêutico no contexto do transplante e indicar formas de condicionamento, de acordo com as características clínicas dos pacientes, como o número de transfusões, com intuito de minimizar a rejeição primária e secundária, garantindo a melhora da sobrevida global e livre de doença (observadas pela literatura e já validadas por resultados na população brasileira. No que concerne à anemia de Fanconi, o transplante é a única modalidade curativa para o componente aplásico de medula óssea; embora não modificando as outras características da síndrome também demanda perícia e agilidade na busca de um doador com resultados expressivos de sobrevida.The guidelines presented in this article have been prepared and approved in the I Meeting of Brazilian Guidelines in Hematopoietic Stem Cell Transplantation (HSCT - Rio de Janeiro, July 19-21, 2009. The event was sponsored by SBTMO (Brazilian Society of Bone Marrow Transplantation. In this paper, we treat the severe aplastic anemia (SAA, considered a hematological emergency, that when identified and medically treated early, shows a great chance of recovery of the hematopoiesis, either through bone marrow transplantation or immunosuppressive therapy. Its objective is to guide the management of the transplantation, and indicate methods of conditioning, according to

  19. Potencial evocado auditivo de tronco encefálico por frequência específica por via aérea e via óssea em neonatos ouvintes normais

    Directory of Open Access Journals (Sweden)

    Natália Ramos

    2014-06-01

    Full Text Available Objetivo determinar os níveis mínimos de resposta (NMR e a latência da onda V do Potencial Evocado Auditivo de Tronco encefálico por Frequência específica (PEATE-FE em neonatos ouvintes normais nas frequências de 0.5, 1, 2 e 4 kHz por via aérea e via óssea e determinar valores normativos. Métodos foram avaliados neonatos com audição normal, sendo realizado o PEATE-FE nas frequências de 0.5, 1, 2 e 4 kHz, tanto por via aérea (VA quanto por via óssea (VO. Para cada frequência, foram avaliadas 12 orelhas em um total de 18 neonatos. A análise dos resultados avaliou o tempo de latência e a presença da onda V até a intensidade de 20 dBnNA para quatro intensidades e para os dois tipos de condução (aérea e óssea. Resultados observou-se aumento da latência da onda V com a diminuição da intensidade e maiores latências nas frequências mais baixas, tanto na VA quanto na VO. Porém, em fortes intensidades, em ambas condições, não houve diferença entre as latências de 0.5 e 1 kHz, contrariando os achados da literatura. Para VA, na frequência de 500 Hz, houve presença da onda V até 30 dBnNA em todas as orelhas, e em 1000 Hz, 11 orelhas (91,66 % apresentaram resposta em 20 dBnNA; nas demais frequências, 100% das orelhas avaliadas apresentaram resposta em 20 dBnNA. Na VO, a presença da onda V em 20 dBnNA foi observada em todas as frequências estudadas. Conclusão os valores descritos podem ser considerados normativos e utilizados na clinica como padrão de normalidade, auxiliando no diagnóstico diferencial da perda auditiva ao nascimento.

  20. A utilização de estímulos de banda limitada na triagem auditiva neonatal com o potencial evocado auditivo de tronco encefálico automático

    Directory of Open Access Journals (Sweden)

    Mabel Goncalves Almeida

    2014-12-01

    Full Text Available OBJETIVO: estudar os resultados obtidos no Potencial Evocado Auditivo de Tronco Encefálico Automático (PEATE-A com um estímulo chirp de bandas limitadas. MÉTODOS: o PEATE-A com o estímulo HiLo CE-Chirp(, na intensidade de 35 dB nNA, foi registrado em 50 recém-nascidos (RN com e sem indicadores de risco para deficiência auditiva (IRDA e comparado ao PEATE por Frequência Específica (PEATE-FE. Foram analisados os resultados "passa/falha" para o estímulo HiLo CE-Chirp( e para os componentes Hi e Lo, separadamente e determinadas medidas de validação. O tempo de detecção de resposta no PEATE-A também foi determinado. RESULTADOS: o PEATE-A com o HiLo CE-Chirp( apresentou alta taxa de falha (36% e de falso-positivos (33%. Diferenças significantes entre as porcentagens de "falha" entre os dois componentes foram observadas, sendo a porcentagem de falha no componente Lo maior que no Hi, nas duas orelhas. O tempo médio de detecção de resposta foi de 63,8 segundos para a orelha direita e 77,9 para a orelha esquerda, sendo observadas diferenças estatisticamente significantes entre as orelhas (p=0,002. CONCLUSÃO: o estímulo de banda limitada apresentou tempo médio de detecção de resposta consideravelmente pequeno e alta sensibilidade, no entanto, devido a alta taxa de falso-positivos, apresentou baixa especificidade, mostrando a importância de novos estudos direcionados, principalmente, para o aperfeiçoamento da técnica e do estímulo, buscando futura aplicação clínica no PEATE-A.

  1. Análise da atividade da enzima conversora da angiotensina na hipertrofia aguda do ventrículo direito em modelo experimental de estenose endovascular ajustável do tronco pulmonar

    Directory of Open Access Journals (Sweden)

    RABELLO Renato Rocha

    2001-01-01

    Full Text Available INTRODUÇÃO: A bandagem do tronco pulmonar (TP tem sido aplicada para treinamento do ventrículo esquerdo (VE em pacientes portadores de transposição das grandes artérias (TGA com septo íntegro. Este procedimento, além de apresentar alta morbi-mortalidade, pode ocasionar alterações da função ventricular a longo prazo. Com o objetivo de analisar a hipertrofia aguda do ventrículo direito (VD, foi implantado um cateter balão no TP de seis cabritos jovens. MATERIAL E MÉTODOS: A sobrecarga sistólica foi aplicada através de insuflações progressivas do balão, durante 96 horas. Esta hipertrofia foi acompanhada por medidas hemodinâmicas diárias, através de cateteres implantados na aorta, VD e TP, além de ecocardiogramas seriados a cada 24 horas, com medidas das espessuras do septo interventricular e dos ventrículos. Ao final das 96 horas, os animais foram mortos para remoção dos corações. Os ventrículos e o septo foram pesados separadamente. Foram colhidas biópsias musculares de cada câmara para análise da atividade da enzima conversora da angiotensina (ECA. Oito cabritos (idade e peso semelhantes foram utilizados como controle para os pesos dos ventrículos e para a atividade da ECA. RESULTADOS: Observou-se um aumento do gradiente VD/TP (p=0,001, com conseqüente aumento da razão VD/VE (p=0,005 durante o tempo de sobrecarga sistólica. Ao fim do protocolo, a parede livre do VD apresentou aumento de espessura (p=0,002 e, conseqüentemente, um aumento do peso indexado (p=0,002. A análise da atividade da ECA revelou aumento somente no músculo do VD hipertrofiado (p=0,002. CONCLUSÃO: O cateter balão foi eficiente em induzir a hipertrofia aguda do VD através do protocolo utilizado. Conseqüentemente, um aumento expressivo da atividade da ECA está associado ao processo de hipertrofia miocárdica induzida por sobrecarga pressórica.

  2. Ramificação e distribuição do tronco pulmonar em relação aos brônquios, em fetos de bovinos azebuados

    Directory of Open Access Journals (Sweden)

    Antonio Augusto Coppi Maciel Ribeiro

    1998-01-01

    Full Text Available Mediante esta pesquisa, estudamos a ramificação e a distribuição das artérias pulmonares em 20 fetos de bovinos azebuados (13 machos e 7 fêmeas, com idades variando entre 6 e 9 meses. As peças foram fixadas em solução aquosa de formol a 10%, e o método de dissecação consistiu da abertura da cavidade torácica desses animais, com vistas à individualização dos vasos arteriais e brônquios. Da artéria pulmonar direita observou-se que, mais comumente, 15 vezes (75%, parte como primeiro colateral o ramo ascendente, seguido do ramo descendente que acompanham os dois brônquios segmentares do brônquio traqueal, os quais irrigam, respectivamente, a porção cranial e caudal do lobo cranial do pulmão. Logo após este arranjo, surgem o ramo lobar acessório e em seguida o ramo lobar médio. O ramo lobar acessório pode emergir duas vezes (10% depois do ramo lobar médio ou na mesma altura dele, cinco vezes (25%. Uma única vez (5% aparecem dois ramos lobares médios. Em cinco preparações (25%, os dois primeiros ramos da artéria pulmonar direita são vistos a nascer em tronco comum, o ramo lobar cranial. Da artéria pulmonar esquerda nascem mais freqüentemente 18 vezes (90% como 1º e 2º colaterais os ramos ascendente e descendente, e respectivamente duas vezes (10% estes ramos provêm de um único colateral, o ramo lobar cranial. Em cada lobo caudal (direito e esquerdo, penetra um ramo lobar caudal (direito e esquerdo que emite número bastante variado de ramos arteriais (6 a 14 do lado direito e (7 a 16 do lado esquerdo.

  3. Lesiones altas del plexo braquial. Reconstrucción con técnicas combinadas de neurotización e injertos nerviosos.

    Directory of Open Access Journals (Sweden)

    enrique manuel vergara amador

    2015-01-01

    Full Text Available Las lesiones altas del plexo braquial  son  reconstruidas  con neurotización e  injerto nervioso. El  nervio espinal accesorio,  la raíz   C7,  ramas del tríceps, y  el nervio mediano y cubital son los más  usados para transferencias. Se muestra la experiencia con  neurotización de la rama inferior del nervio espinal accesorio (NEA al nervio supraescapular (NSE, transferencia nerviosa de fascículos del nervio cubital o del mediano, y en ocasiones  injertos nervioso hacia el nervio musculocutáneo  y al tronco posterior, y reconstrucción del nervio axilar  en algunos casos. Materiales y métodos Se revisan 42  pacientes  con  lesiones altas de plexo braquial, operados  mediante combinación de   neurotización  e injertos nerviosos. Seguimiento mínimo de 15 meses. Resultados  40 pacientes fueron por accidente en moto. En 22 se  transfirió únicamente el NSE con el NEA, recuperando  abducción de hombro  de 33º  En 8  pacientes  que se combinó con reparación del axilar, mejoró la abducción a 81º. En 30 pacientes con neurotización del nervio cubital o mediano para el bíceps, se obtuvo respuesta  entre 3 y 4 meses. Al  final  flexión  del codo de 116º y M4. Discusión Los mejores resultados  en  hombro  fueron con la combinación  de NSE y del nervio axilar, logrando 81º de abducción. La rotación externa  mejoro  en 28.5% de los pacientes, siendo una respuesta tardía La neurotización  del bíceps con fascículos del cubital consiguió una flexión    de 116º, muy  comparable con otras series. Hoy  esta técnica es el  gold estándar   para la reconstrucción de  flexión del codo.

  4. La identidad del sujeto. Un estudio basado en el cerebro y el cuerpo

    OpenAIRE

    Pastor Hervás, Eva María

    2015-01-01

    Investigación sobre la construcción del sujeto a partir de la influencia de nuestra prehistoria en nuestro cerebro y sus consecuencias a día de hoy. Iniciando el estudio en la asunción de la importancia del cerebro, al eliminar el dualismo mente-cerebro partiendo de Quine y el materialismo eliminativo de Paul y Patricia Churchland, para proseguir con el ámbito del cableado cerebral, la influencia de las hormonas y la evolución de nuestra sexualidad en la identidad de los sujetos, sobre tod...

  5. Identification of the wood-borer and the factors affecting its attack on Caryocar brasiliense trees in the Brazilian Savanna=Identificação do broqueador de tronco e os fatores que afetam o seu ataque em árvores de Caryocar brasiliense no cerrado brasileiro.

    Directory of Open Access Journals (Sweden)

    Germano Leão Demolin Leite

    2011-10-01

    Full Text Available The objectives of this work were to identify the wood-borer of the trunk of Caryocar brasiliense Camb. (Caryocaraceae and the effects of tree size, chemical and physical soil attributes, and floristic diversity in its attack. The wood-boring caterpillar of the trunck of C. brasiliense belongs to the family Cossidae (Lepidoptera. The number of pupae and the amount of sawdust produced by the wood-borer per tree was higher in the pasture 1 of Montes Claros and pasture in Ibiracatu than in the other four areas (pastures and savanna in Montes Claros and savanna in Ibiracatu. The number of pupae and the amount of sawdust was highest in the trunks of trees with diameters having a breast height (DBH more than 30 cm. This may explain the severity of attack in the areas mentioned above, which contain a higher percentage of plants with DBH> 30 cm. The soil properties also positively associate with higher attack of the wood-borer on trees when the soil is rich in potassium, calcium, magnesium, sum of bases, capacity of cationic exchange, and organic matter, while there was a negative correlation between attack and fine sand content. Systems with less floristic diversity, particularly trees of other species, may concentrate the attack of the wood-borer in the trunks of C. Brasiliense trees. Os objetivos deste trabalho foram identificar o broqueador do tronco de Caryocar brasiliense Camb. (Caryocaraceae e os efeitos de tamanho de árvore, atributos químico-físicos do solo e da diversidade florística em seu ataque. A lagarta broqueadora do tronco de C. brasiliense pertence à família Cossidae (Lepidoptera. O número de pupas e de serragem do broqueador por árvore foi maior na pastagem (1 em Montes Claros e pastagem em Ibiracatu do que nas outras quatro áreas (pastagens e cerrado em Montes Claros e cerrado em Ibiracatu. O número de pupas e da quantidade de serragem do broqueador foi maior em árvores cujo diâmetro de tronco na altura do peito (DAB foi

  6. MRI diagnosis of the cerebral schistosomiasis

    International Nuclear Information System (INIS)

    Liu Hanqiu; Chen Yuanjun

    2002-01-01

    Objective: To discuss MRI appearance of the cerebral schistosomiasis and its clinical value through analyzing the MRI features and post-surgery pathological findings. Methods: MRI features of the cerebral schistosomiasis in 16, pathologically (n = 6) or clinically (n = 10) proved cases were analyzed retrospectively, and compared with the post-surgery pathological findings in 6 cases. Results: Single masses were found in 11 cases (11/16), and multiple masses in 5 eases (5/16), amounting to 23 masses . fifteen masses (15/23) were located in right cerebral hemisphere, including frontal lobe (n = 2), frontoparietal lobe (n = 5) , and occipitoparietal lobe (n 8), while 8 masses (8/23) in left cerebral hemisphere, including frontal lobe (n = 1), frontoparietal lobe (n = 3), and occipitoparietal lobe (n = 4). The nodular masses were isointense with the gray mass like 'island', and 12 cases (12/16) show the 'gigantic hand' form of edema around them. After IV administration of Gd-DTPA, 15 cases (15/16) revealed multiple closely spaced, intensely enhancing modules, 1-3 mm in diameter, distributed throughout the mass. Seven cases misdiagnosed by CT were revised by MRl. Conclusion: The MRI appearance of the cerebral schistosomiasis is characteristic, and MRI is the most valuable tool to diagnose it without injury

  7. Regional Cerebral Perfusion in Progressive Supranuclear Palsy

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Won Yong; Lee, Ki Hyeong; Yoon, Byung Woo; Lee, Sang Bok; Jeon, Beom S. [Samsung Medical Center, Seoul (Korea, Republic of); Lee, Kyung Han; Lee, Myung Chul [Seoul National University College of Medicine, Seoul (Korea, Republic of)

    1996-03-15

    Progressive supranuclear palsy (PSP) is a Parkinson-plus syndrome characterized clinically by supranuclear ophthalmoplegia, pseudobulbar palsy, axial rigidity, bradykinesia, postural instability and dementia. Presence of dementia and lack of cortical histopathology suggest the derangement of cortical function by pathological changes in subcortical structures in PSP, which is supported by the pattern of behavioral changes and measurement of brain metabolism using positron emission tomography. This study was done to examine whether there are specific changes of regional cerebral perfusion in PSP and whether there is a correlation between severity of motor abnormaility and degree of changes in cerebral perfusion. We measured regional cerebral perfusion indices in 5 cortical and 2 subcortical areas in 6 patients with a clinical diagnosis of PSP and 6 healthy age and sex matched controls using Tc-99m-HMPAO SPECT. Compared with age and sex matched controls, only superior frontal regional perfusion index was significantly decreased in PSP (p<0.05). There was no correlation between the severity of the motor abnormality and any of the regional cerebral perfusion indices (p>0.05). We affirm the previous reports that perfusion in superior frontal cortex is decreased in PSP. Based on our results that there was no correlation between severity of motor abnormality and cerebral perfusion in the superior frontal cortex, nonmotoric symptoms including dementia needs to be looked at whether there is a correlation with the perfusion abnormality in superior frontal cortex

  8. Cerebral Vascular Injury in Traumatic Brain Injury.

    Science.gov (United States)

    Kenney, Kimbra; Amyot, Franck; Haber, Margalit; Pronger, Angela; Bogoslovsky, Tanya; Moore, Carol; Diaz-Arrastia, Ramon

    2016-01-01

    Traumatic cerebral vascular injury (TCVI) is a very frequent, if not universal, feature after traumatic brain injury (TBI). It is likely responsible, at least in part, for functional deficits and TBI-related chronic disability. Because there are multiple pharmacologic and non-pharmacologic therapies that promote vascular health, TCVI is an attractive target for therapeutic intervention after TBI. The cerebral microvasculature is a component of the neurovascular unit (NVU) coupling neuronal metabolism with local cerebral blood flow. The NVU participates in the pathogenesis of TBI, either directly from physical trauma or as part of the cascade of secondary injury that occurs after TBI. Pathologically, there is extensive cerebral microvascular injury in humans and experimental animal, identified with either conventional light microscopy or ultrastructural examination. It is seen in acute and chronic TBI, and even described in chronic traumatic encephalopathy (CTE). Non-invasive, physiologic measures of cerebral microvascular function show dysfunction after TBI in humans and experimental animal models of TBI. These include imaging sequences (MRI-ASL), Transcranial Doppler (TCD), and Near InfraRed Spectroscopy (NIRS). Understanding the pathophysiology of TCVI, a relatively under-studied component of TBI, has promise for the development of novel therapies for TBI. Published by Elsevier Inc.

  9. Association of Lead Levels and Cerebral Palsy

    Science.gov (United States)

    Bansal, Neha; Aggarwal, Anju; Faridi, M. M. A.; Sharma, Tusha; Baneerjee, B. D.

    2017-01-01

    Background: Cerebral palsy is a common motor disability in childhood. Raised lead levels affect cognition. Children with cerebral palsy may have raised lead levels, further impairing their residual cognitive motor and behavioral abilities. Environmental exposure and abnormal eating habits may lead to increased lead levels. Aims and Objectives: To measure blood lead levels in children with cerebral palsy and compare them with healthy neurologically normal children. To correlate blood lead levels with environmental factors. Material and Methods: Design: Prospective case-control study. Setting: Tertiary care hospital. Participants: Cases comprised 34 children with cerebral palsy, and controls comprised 34 neurologically normal, age- and sex-matched children. Methods: Clinical and demographic details were recorded as per proforma. Detailed environmental history was recorded to know the source of exposure to lead. These children were investigated and treated as per protocol. Venous blood was collected in ethylenediaminetetraacetic acid vials for analysis of blood lead levels. Lead levels were estimated by Schimadzu Flame AA-6800 (atomic absorption spectrophotometer). Data were analyzed using SPSS version 17. P pica were 12.33 ± 10.02 µg/dL in comparison to children with no history of pica, 6.70 ± 4.60 µg/dL (P = .029). No correlation was found between hemoglobin and blood lead levels in cases and controls. Conclusion: In our study, blood lead levels are raised in children with cerebral palsy. However, further studies are required to show effects of raised levels in these children. PMID:28491920

  10. Pathological review of late cerebral radionecrosis

    International Nuclear Information System (INIS)

    Yoshii, Yoshihiko

    2008-01-01

    Late cerebral radionecrosis may be considered to be a specific chronic inflammatory response, although it is unknown whether the initial damage by brain irradiation is to an endothelial cell or a glial cell. I discuss the pathological specificity of late cerebral radionecrosis by studying the published literature and a case that I experienced. In late cerebral radionecrosis, there are typical coagulation necrosis areas containing fibrinoid necrosis with occlusion of the lumina and poorly active inflammatory areas with many inflammatory ghost cells, focal perivascular lymphocytes, hyalinized vessels, and telangiectatic vascularization near and in the necrotic tissue, and more active inflammatory areas formed as a partial rim of the reactive zone by perivascular lymphocytes, much vascularization, and glial fibrillary acidic protein (GFAP)-positive astrocytes at the corticomedullary border adjacent to necrotic tissue in the white matter. It is difficult to believe that coagulation necrosis occurs without first disordering the vascular endothelial cells because fibrinoid necrosis is a main feature and a diffusely multiple lesion in late cerebral radionecrosis. Because various histological findings do develop, progress, and extend sporadically at different areas and times in the irradiated field of the brain for a long time after radiation, uncontrolled chronic inflammation containing various cytokine secretions may also play a key role in progression of this radionecrosis. Evaluation of the mechanism of the development/aggravation of late cerebral radionecrosis requires a further study for abnormal cytokine secretions and aberrant inflammatory reactions. (author)

  11. Cerebral oxygenation in patients undergoing shoulder surgery in beach chair position: comparing general to regional anesthesia and the impact on neurobehavioral outcome.

    Science.gov (United States)

    Aguirre, J; Borgeat, A; Trachsel, T; Cobo Del Prado, I; De Andrés, J; Bühler, P

    2014-02-01

    Ischemic brain damage has been reported in healthy patients after beach chair position for surgery due to cerebral hypoperfusion. Near-infrared spectroscopy has been described as a non-invasive, continuous method to monitor cerebral oxygen saturation. However, its impact on neurobehavioral outcome comparing different anesthesia regimens has been poorly described. In this prospective, assessor-blinded study, 90 patients undergoing shoulder surgery in beach chair position following general (G-group, n=45) or regional anesthesia (R-group; n=45) were enrolled to assess the prevalence of cerebral desaturation events comparing anesthesia regimens and their impact on neurobehavioral and neurological outcome. Anesthesiologists were blinded to regional cerebral oxygen saturation values. Baseline data assessed the day before surgery included neurological and neurobehavioral tests, which were repeated the day after surgery. The baseline data for regional cerebral oxygen saturation/bispectral index and invasive blood pressure both at heart and auditory meatus levels were taken prior to anesthesia, 5 min after induction of anesthesia, 5 min after beach chair positioning, after skin incision and thereafter all 20 min until discharge. Patients in the R-group showed significantly less cerebral desaturation events (psurgery (pshoulder surgery in beach chair position influencing neurobehavioral test results at 24h. Copyright © 2013 Sociedad Española de Anestesiología, Reanimación y Terapéutica del Dolor. Published by Elsevier España. All rights reserved.

  12. Dynamic Cerebral Autoregulation in Homozygous Sickle Cell Disease

    NARCIS (Netherlands)

    Kim, Yu-Sok; Nur, Erfan; van Beers, Eduard J.; Truijen, Jasper; Davis, Shyrin C. A. T.; Biemond, Bart J.; van Lieshout, Johannes J.

    2009-01-01

    Background and Purpose-Sickle cell disease (SCD) is associated with cerebral hyperperfusion and an increased risk of stroke. Also, both recurrent microvascular obstruction and chronic hemolysis affect endothelial function, potentially interfering with systemic and cerebral blood flow control. We

  13. Gastrostomy tube feeding of children with cerebral palsy

    DEFF Research Database (Denmark)

    Dahlseng, Magnus O; Andersen, Guro L; DA Graca Andrada, Maria

    2012-01-01

    To compare the prevalence of gastrostomy tube feeding (GTF) of children with cerebral palsy (CP) in six European countries.......To compare the prevalence of gastrostomy tube feeding (GTF) of children with cerebral palsy (CP) in six European countries....

  14. Cerebral Palsy Checklist: Babies & Preschoolers (Birth to age 5)

    Science.gov (United States)

    ... Staying Safe Videos for Educators Search English Español Cerebral Palsy Checklist: Babies & Preschoolers KidsHealth / For Parents / Cerebral Palsy Checklist: Babies & Preschoolers What's in this article? Step ...

  15. Cerebral Palsy Checklist: Teens & Young Adult (13 to 21)

    Science.gov (United States)

    ... Staying Safe Videos for Educators Search English Español Cerebral Palsy Checklist: Teens & Young Adults KidsHealth / For Parents / Cerebral Palsy Checklist: Teens & Young Adults What's in this article? ...

  16. Cerebral near infrared spectroscopy oximetry in extremely preterm infants

    DEFF Research Database (Denmark)

    Hyttel-Sorensen, Simon; Pellicer, Adelina; Alderliesten, Thomas

    2015-01-01

    OBJECTIVE: To determine if it is possible to stabilise the cerebral oxygenation of extremely preterm infants monitored by cerebral near infrared spectroscopy (NIRS) oximetry. DESIGN: Phase II randomised, single blinded, parallel clinical trial. SETTING: Eight tertiary neonatal intensive care unit...

  17. Cerebral vascular control and metabolism in heat stress

    DEFF Research Database (Denmark)

    Bain, Anthony R; Nybo, Lars; Ainslie, Philip N

    2015-01-01

    implications and pathologies known to confound cerebral functioning during hyperthermia. A reduction in cerebral blood flow (CBF), derived primarily from a respiratory-induced alkalosis, underscores the cerebrovascular changes to hyperthermia. Arterial pressures may also become compromised because of reduced...

  18. Association between type of cerebral palsy and the cognitive levels

    Directory of Open Access Journals (Sweden)

    Ratna Dewi Kusumaningrum

    2009-07-01

    Conclusion Our data showed that most patients with cerebral palsy had mental retardation of several cognitive level but there was no significant association between each type of cerebral palsy with cognitive levels.

  19. Admission Hyperglycemia and Clinical Outcome in Cerebral Venous Thrombosis

    NARCIS (Netherlands)

    Zuurbier, Susanna M.; Hiltunen, Sini; Tatlisumak, Turgut; Peters, Guusje M.; Silvis, Suzanne M.; Haapaniemi, Elena; Kruyt, Nyika D.; Putaala, Jukka; Coutinho, Jonathan M.

    2016-01-01

    Background and Purpose-Admission hyperglycemia is associated with poor clinical outcome in ischemic and hemorrhagic stroke. Admission hyperglycemia has not been investigated in patients with cerebral venous thrombosis. Methods-Consecutive adult patients with cerebral venous thrombosis were included

  20. LATERALIDAD CEREBRAL Y ENFERMEDAD MENTAL

    Directory of Open Access Journals (Sweden)

    Roberto Serpa Florez

    1984-11-01

    Full Text Available

    La Academia Sueca de Ciencias al conceder en 1981 el Premio Nobel de Medicina a Roger Sperry, David Hubbel y Torsten Wiesel, no hizo más que reconocer, un poco tardíamente, quizás, la rigurosa, tenaz y admirable obra científica de muchos años, de tres eminentes
    investigadores de las neurociencias: Hubbel y Wiesel por su trabajos sobre la corteza visual del cerebro, y Sperry por su labor sobre el funcionamiento de los hemisferios cerebrales que ya desde hace veinte años se publicó en muy conocidas revistas científicas.

    El estudio experimental de las modificaciones producidas por la comisurotomía en la conducta
    de los pacientes, se hizo utilizando métodos ingeniosísimos de investigación. "Los resultados indican, en palabras de Sperry, Gazzaniga y Bogen: "una desunión funcional de los hemisferios derecho e izquierdo, para casi todas las actividades cognoscitivas y otras
    actividades psíquicas. Se ha encontrado que el aprendizaje y la memoria proceden independientemente de cada hemisferio separado. Cada hemisferio parece tener su propia esfera de conciencia para la sensación, la percepción, la ideación y otras actividades mentales y el dominio interno total de la experiencia gnóstica propia está dividida de las experiencias correspondientes del otro hemisferio, con pocas excepciones solamente"...

  1. Hypothermia reduces cerebral metabolic rate and cerebral blood flow in newborn pigs

    International Nuclear Information System (INIS)

    Busija, D.W.; Leffler, C.W.

    1987-01-01

    The authors examined effects of hypothermia on cerebral metabolic rate and cerebral blood flow in anesthetized, newborn pigs (1-4 days old). Cerebral blood flow (CBF) was determined with 15-μm radioactive microspheres. Regional CBF ranged from 44 to 66 ml·min -1 ·100 g -1 , and cerebral metabolic rate was 1.94 ± 0.23 ml O 2 ·100 g -1 ·min -1 during normothermia (39 degree C). Reduction of rectal temperature to 34-35 degree C decreased CBF and cerebral metabolic rate 40-50%. In another group of piglets, they examined responsiveness of the cerebral circulation to arterial hypercapnia during hypothermia. Although absolute values for normocapnic and hypercapnic CBF were reduced by hypothermia and absolute values for normocapnic and hypercapnic cerebrovascular resistance were increased, the percentage changes from control in these variables during hypercapnia were similar during normothermia and hypothermia. In another group of animals that were maintained normothermic and exposed to two episodes of hypercapnia, there was no attenuation of cerebrovascular dilation during the second episode. They conclude that hypothermia reduces CBF secondarily to a decrease in cerebral metabolic rate and that percent dilator responsiveness to arterial hypercapnia is unaltered when body temperature is reduced

  2. Sodium transport through the cerebral sodium-glucose transporter exacerbates neuron damage during cerebral ischaemia.

    Science.gov (United States)

    Yamazaki, Yui; Harada, Shinichi; Wada, Tetsuyuki; Yoshida, Shigeru; Tokuyama, Shogo

    2016-07-01

    We recently demonstrated that the cerebral sodium-glucose transporter (SGLT) is involved in postischaemic hyperglycaemia-induced exacerbation of cerebral ischaemia. However, the associated SGLT-mediated mechanisms remain unclear. Thus, we examined the involvement of cerebral SGLT-induced excessive sodium ion influx in the development of cerebral ischaemic neuronal damage. [Na+]i was estimated according to sodium-binding benzofuran isophthalate fluorescence. In the in vitro study, primary cortical neurons were prepared from fetuses of ddY mice. Primary cortical neurons were cultured for 5 days before each treatment with reagents, and these survival rates were assessed using biochemical assays. In in vivo study, a mouse model of focal ischaemia was generated using middle cerebral artery occlusion (MCAO). In these experiments, treatment with high concentrations of glucose induced increment in [Na+]i, and this phenomenon was suppressed by the SGLT-specific inhibitor phlorizin. SGLT-specific sodium ion influx was induced using a-methyl-D-glucopyranoside (a-MG) treatments, which led to significant concentration-dependent declines in neuronal survival rates and exacerbated hydrogen peroxide-induced neuronal cell death. Moreover, phlorizin ameliorated these effects. Finally, intracerebroventricular administration of a-MG exacerbated the development of neuronal damage induced by MCAO, and these effects were ameliorated by the administration of phlorizin. Hence, excessive influx of sodium ions into neuronal cells through cerebral SGLT may exacerbate the development of cerebral ischaemic neuronal damage. © 2016 Royal Pharmaceutical Society.

  3. Efecto neuroprotector del Lepidium meyenii, ecotipo negro (maca negra) en ratas crías frente al daño cerebral inducido por la ingesta de sulfato ferroso y vitamina C durante la gestación de las ratas madre

    OpenAIRE

    Troncoso, Luzmila; Guija, Emilio; Palomino, Felio; Soberón, Mercedes; Oliveira, Gisela; Núñez, Marco; Flores, Juana; Acuña, Sheresnarda; Terrazas, Carmen

    2013-01-01

    Objetivo: Evaluar el efecto neuroprotector del Lepidium meyenii, ecotipo negro en ratas crías por ingesta de sulfato ferroso y vitamina C (SFC) durante la gestación de ratas madre. Diseño: Experimental, analítico. Institución: Centro de Investigación de Bioquímica y Nutrición. Material biológico: Lepidium meyenii, ecotipo negro (maca negra: MN), ratas. Intervenciones: Se distribuyeron 30 ratas albinas de dos meses de edad, en tres grupos. Tratamiento en los últimos 7 días de gestación: grupo ...

  4. Cerebral hemorrhage caused by amyloid angiopathy

    International Nuclear Information System (INIS)

    Hanyu, Haruo; Tomonaga, Masanori; Yoshimura, Masahiro; Yamanouchi, Hiroshi; Shimada, Hiroyuki.

    1985-01-01

    Cerebral hemorrhage caused by amyloid angiopathy was studied clinicopathologically, with special attention given to the CT images. Cerebral hemorrhage caused by amyloid angiopathy is characterized, by a lobar-type hemorrhage involving the cortex, with direct extension into the subarachnoid space. Multiple hemorrhages are frequent, and cortical infarctions are present as complications in elderly patients without risk factors. CT scans taken in 5 cases demonstrated lobar hemorrhages in superficial locations, frequently in multiple sites or recurrently, with surrounding edema and mass effect. A subarachnoid extension of the hemorrhage through the superficial cortex, proven pathologically in all cases, was noted by CT in 4 of the 5 cases. However, cortical infarction was not detected by CT in any case. Therefore, CT is of value in the diagnosis of cerebral hemorrhage due to amyloid angiopathy based on distinctive findings such as a lobar hemorrhage in superficial regions, with extension into the subarachnoid space, frequently in multiple sites or recurrently. (author)

  5. Computerized tomographic evaluation of cerebral cysticercosis

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Bo Young; Lee, Mi Sook; Jeon, Doo Sung; Kim, Hong Soo; Rhee, Hak Song [Precbyterian Medical Center, Chonju (Korea, Republic of)

    1988-08-15

    Cerebral cysticercosis, unfortunately frequent in Korea, is a parastic disease in which man serve as the intermediate host of taenia solium. The larvae have a predilection for the central nervous system and can cause a variety of neurologic symptoms. The authors reviewed 19 cases of surgically proven cerebral cysticercosis and following results were obtained. 1. The most frequent age distribution was 5th and 6th decade and male to female ratio was 14:5. 2. The most frevalent involving site was cerebral parenchyme and following by ventricles. 3. Clinical manifestations were symtom and sign of increased ICP, seizure and focal neurological dificit. 4. It was assumed that computerized tomography was the procedure of choice for the diagnosis of these parasitic brain disease.

  6. Diagnosis of cerebral disorders using computed tomography

    Energy Technology Data Exchange (ETDEWEB)

    Kitamura, K [Tokyo Women' s Medical Coll. (Japan)

    1980-01-01

    Computed tomography (CT), which makes differential diagnosis of cerebral disorders possible, was applied in the diagnosis of hypertensive intracerebral hemorrhage, cerebral thrombosis, subarachnoid hemorrhage, and cerebrovascular Moyamoya disease. CT findings of hypertensive intracerebral hemorrhage showed the localization, volume, and direction of hematoma, and the classification of hematoma according to CT findings was highly correlated to the clinical symptoms of the patients. CT findings of cerebral thrombosis showed the extension of the lesion to be a low density area, but there were many cases in which they did not show a low density area immediately after an attack. CT findings of subarachnoid hemorrhage were very useful in the diagnosis of intracerebral hematoma, ventricular hematoma, and intracranial hematoma secondary to this disease. However, it was very difficult to diagnose cerebrovascular Moyamoya disease by means of CT.

  7. Diagnosis of cerebral disorders using computed tomography

    International Nuclear Information System (INIS)

    Kitamura, Koichi

    1980-01-01

    Computed tomography (CT), which makes differential diagnosis of cerebral disorders possible, was applied in the diagnosis of hypertensive intracerebral hemorrhage, cerebral thrombosis, subarachnoid hemorrhage, and cerebrovascular Moyamoya disease. CT findings of hypertensive intracerebral hemorrhage showed the localization, volume, and direction of hematoma, and the classification of hematoma according to CT findings was highly correlated to the clinical symptoms of the patients. CT findings of cerebral thrombosis showed the extension of the lesion to be a low density area, but there were many cases in which they did not show a low density area immediately after an attack. CT findings of subarachnoid hemorrhage were very useful in the diagnosis of intracerebral hematoma, ventricular hematoma, and intracranial hematoma secondary to this disease. However, it was very difficult to diagnose cerebrovascular Moyamoya disease by means of CT. (Nishio, M.)

  8. Neurociências, neurocultura e autoajuda cerebral

    Directory of Open Access Journals (Sweden)

    Francisco Ortega

    Full Text Available Este artigo pretende analisar o fenômeno denominado de neuroascese, ou autoajuda cerebral no contexto do crescente impacto das neurociências e do surgimento da neurocultura e do sujeito cerebral. Para tanto, é importante compreender o âmbito sóciocultural mais amplo no qual a neuroascese se insere e que corresponde ao que vem se chamando de 'cultura somática' ou, mais especificamente, de biossociabilidade. O objetivo do artigo é explorar como uma forma de subjetividade reducionista, o sujeito cerebral, dá lugar à aparição de práticas de si cerebrais, isto é, práticas de como agir sobre o cérebro para maximizar a sua performance, que levam a formação de novas formas de sociabilidade.

  9. Contrast MR imaging of acute cerebral infarction

    Energy Technology Data Exchange (ETDEWEB)

    Kogame, Saeko; Syakudo, Miyuki; Inoue, Yuichi (Osaka City Univ. (Japan). Faculty of Medicine) (and others)

    1992-04-01

    Thirty patients with acute and subacute cerebral infarction (13 and 17 deep cerebral infarction) were studied with 0.5 T MR unit before and after intravenous injection of Gd-DTPA. Thirteen patients were studied within 7 days after neurological ictus, 17 patients were studied between 7 and 14 days. Two types of abnormal enhancement, cortical arterial and parenchymal enhancement, were noted. The former was seen in 3 of 4 cases of very acute cortical infarction within 4 days after clinical ictus. The latter was detected in all 7 cases of cortical infarction after the 6th day of the ictus, and one patient with deep cerebral infarction at the 12th day of the ictus. Gd-DTPA enhanced MR imaging seems to detect gyral enhancement earlier compared with contrast CT, and depict intra-arterial sluggish flow which was not expected to see on contrast CT scans. (author).

  10. Cerebral venography and flow quantification with MR

    International Nuclear Information System (INIS)

    Mattle, H.; Elelman, R.R.; Reis, H.H.; O'Reilly, G.V.; Wentz, K.V.; O'Leary, D.H.; Finn, J.P.; Longmaid, H.E.

    1989-01-01

    The authors describe an approach for creating projection venograms of the head and quantifying flow in the cerebral veins and sinuses. A series of two- dimensional flow-compensated gradient-echo images were acquired. Signal from arteries was eliminated by application of a 5-cm-thick presaturation slab to the neck. The images were postprocessed with use of a maximum intensity projection algorithm to produce projection venograms. In addition, flow directionally, flow velocity, and, in the superior sagittal sinus (SSS), flow volume was assessed by means of a dynamic bolus tracking technique. Flow velocities in the SSS ranged from 20.1 to 45.5 cm/sec, and flow volumes from 269 to 612 mL/min. This technique was able to identify cerebral venous thrombosis and partial SSS obstruction, cerebral venous angiomas, and venous drainage of arteriovenous malformations and to demonstrate patency of the SSS with falx meningiomas

  11. Cerebral blood flow variations in CNS lupus

    International Nuclear Information System (INIS)

    Kushner, M.J.; Tobin, M.; Fazekas, F.; Chawluk, J.; Jamieson, D.; Freundlich, B.; Grenell, S.; Freemen, L.; Reivich, M.

    1990-01-01

    We studied the patterns of cerebral blood flow (CBF), over time, in patients with systemic lupus erythematosus and varying neurologic manifestations including headache, stroke, psychosis, and encephalopathy. For 20 paired xenon-133 CBF measurements, CBF was normal during CNS remissions, regardless of the symptoms. CBF was significantly depressed during CNS exacerbations. The magnitude of change in CBF varied with the neurologic syndrome. CBF was least affected in patients with nonspecific symptoms such as headache or malaise, whereas patients with encephalopathy or psychosis exhibited the greatest reductions in CBF. In 1 patient with affective psychosis, without clinical or CT evidence of cerebral ischemia, serial SPECT studies showed resolution of multifocal cerebral perfusion defects which paralleled clinical recovery

  12. Training model for cerebral aneurysm clipping

    Directory of Open Access Journals (Sweden)

    Hiroshi Tenjin, M.D., Ph.D.

    2017-12-01

    Full Text Available Clipping of cerebral aneurysms is still an important skill in neurosurgery. We have made a training model for the clipping of cerebral aneurysms. The concepts for the model were 1: training model for beginners, 2: three dimensional manipulation using an operating microscope, 3: the aneurysm model is to be perfused by simulated blood causing premature rupture. The correct relationship between each tissue, and softness of the brain and vessels were characteristics of the model. The skull, brain, arteries, and veins were made using a 3D printer with data from DICOM. The brain and vessels were made from polyvinyl alcohol (PVA. One training course was held and this model was useful for training of cerebral aneurysm surgery for young neurosurgeons.

  13. Cerebral vascular effects of hypovolemia and dopamine infusions

    DEFF Research Database (Denmark)

    Holst Hahn, Gitte; Heiring, Christian; Pryds, Ole

    2012-01-01

    Despite widespread use, effects of volume boluses and dopamine in hypotensive newborn infants remain controversial. We aimed to elucidate if hypovolemia alone impairs cerebral autoregulation (CA) and if dopamine affects cerebral vasculature.......Despite widespread use, effects of volume boluses and dopamine in hypotensive newborn infants remain controversial. We aimed to elucidate if hypovolemia alone impairs cerebral autoregulation (CA) and if dopamine affects cerebral vasculature....

  14. Magnetic resonance spectroscopy and imaging in cerebral ischemia

    International Nuclear Information System (INIS)

    Rijen, P.C. van.

    1991-01-01

    In-vivo proton and phosphorus magnetic resonance spectroscopy was used to detect changes in cerebral metabolism during ischemia and other types of metabolic stress. Magnetic resonance imaging was performed in an animal model to observe morphological alterations during focal cerebral ischemia. Spectroscopy was performed in animal models with global ischemia, in volunteers during hyperventilation and pharmaco-logically altered cerebral perfusion, and in patients with acute and prolonged focal cerebral ischemia. (author). 396 refs.; 44 figs.; 14 tabs

  15. Bedside Monitoring of Cerebral Energy State During Cardiac Surgery

    DEFF Research Database (Denmark)

    Mölström, Simon; Nielsen, Troels H; Andersen, Claus

    2017-01-01

    OBJECTIVES: This study investigated whether the lactate-to-pyruvate (LP) ratio obtained by microdialysis (MD) of the cerebral venous outflow reflected a derangement of global cerebral energy state during cardiopulmonary bypass (CPB). DESIGN: Interventional, prospective, randomized study. SETTING...... in either group during CPB. In each group, 50% of the patients showed significant cognitive decline (mini-mental state examination, 3 points) 2 days after surgery. CONCLUSION: The LP ratio of cerebral venous blood increased significantly during CPB, indicating compromised cerebral oxidative metabolism...

  16. The value of computed tomography in cerebral syphilis

    International Nuclear Information System (INIS)

    Godt, P.; Stoeppler, L.; Wischer, U.; Schroeder, H.H.

    1979-01-01

    The computed tomographic findings of three patients with cerebral syphilis, including cerebral gumma, which regressed completely under penicillin therapy, syphilitic angiitis with cerebral infarction, and syphilitic cerebral atrophy, are reported CT is unable to provide specific diagnostic data for these conditions. The etiology can be clarified only by taking into consideration the clinical findings and course, the serological results, and the result of therapy. (orig.) [de

  17. Normal cerebral FDG uptake during childhood

    International Nuclear Information System (INIS)

    London, Kevin; Howman-Giles, Robert

    2014-01-01

    Current understanding of cerebral FDG uptake during childhood originates from a small number of studies in patients with neurological abnormalities. Our aim was to describe cerebral FDG uptake in a dataset of FDG PET scans in children more likely to represent a normal population. We reviewed cerebral FDG PET scans in children up to 16 years of age with suspected/proven extracranial malignancies and the following exclusions: central nervous system metastases, previous malignancies, previous chemotherapy or radiotherapy, development of cerebral metastases during therapy, neurological conditions, taking antiepileptic medication or medications likely to interfere with cerebral metabolism, and general anaesthesia within 24 h. White matter, basal ganglia, thalamus and the cerebellar cortex were analysed using regional SUV max , and the cerebral cortex, basal ganglia, thalamus and cerebellum were analysed using a regional relative uptake analysis in comparison to maximal cortical uptake. Scans from 30 patients (age range 11 months to 16 years, mean age 10 years 5 months) were included. All regions showed increasing SUV max with age. The parietal, occipital, lateral temporal and medial temporal lobes showed lower rates of increasing FDG uptake causing changing patterns of regional FDG uptake during childhood. The cortical regions showing the most intense uptake in early childhood were the parietal and occipital lobes. At approximately 7 years of age these regions had relatively less uptake than the frontal lobes and at approximately 10 years of age these regions had relatively less uptake than the thalamus. Relative FDG uptake in the brain has not reached an adult pattern by 1 year of age, but continues to change up to 16 years of age. The changing pattern is due to different regional rates of increasing cortical FDG uptake, which is less rapid in the parietal, occipital and temporal lobes than in the frontal lobes. (orig.)

  18. Cerebral microbleeds in a neonatal rat model.

    Directory of Open Access Journals (Sweden)

    Brianna Carusillo Theriault

    Full Text Available In adult humans, cerebral microbleeds play important roles in neurodegenerative diseases but in neonates, the consequences of cerebral microbleeds are unknown. In rats, a single pro-angiogenic stimulus in utero predisposes to cerebral microbleeds after birth at term, a time when late oligodendrocyte progenitors (pre-oligodendrocytes dominate in the rat brain. We hypothesized that two independent pro-angiogenic stimuli in utero would be associated with a high likelihood of perinatal microbleeds that would be severely damaging to white matter.Pregnant Wistar rats were subjected to intrauterine ischemia (IUI and low-dose maternal lipopolysaccharide (mLPS at embryonic day (E 19. Pups were born vaginally or abdominally at E21-22. Brains were evaluated for angiogenic markers, microhemorrhages, myelination and axonal development. Neurological function was assessed out to 6 weeks.mRNA (Vegf, Cd31, Mmp2, Mmp9, Timp1, Timp2 and protein (CD31, MMP2, MMP9 for angiogenic markers, in situ proteolytic activity, and collagen IV immunoreactivity were altered, consistent with an angiogenic response. Vaginally delivered pups exposed to prenatal IUI+mLPS had spontaneous cerebral microbleeds, abnormal neurological function, and dysmorphic, hypomyelinated white matter and axonopathy. Pups exposed to the same pro-angiogenic stimuli in utero but delivered abdominally had minimal cerebral microbleeds, preserved myelination and axonal development, and neurological function similar to naïve controls.In rats, pro-angiogenic stimuli in utero can predispose to vascular fragility and lead to cerebral microbleeds. The study of microbleeds in the neonatal rat brain at full gestation may give insights into the consequences of microbleeds in human preterm infants during critical periods of white matter development.

  19. Normal cerebral FDG uptake during childhood

    Energy Technology Data Exchange (ETDEWEB)

    London, Kevin [The Children' s Hospital at Westmead, Department of Nuclear Medicine, Sydney, NSW (Australia); University of Sydney, Discipline of Paediatrics and Child Health, Sydney Medical School, Sydney, NSW (Australia); Howman-Giles, Robert [The Children' s Hospital at Westmead, Department of Nuclear Medicine, Sydney, NSW (Australia); University of Sydney, Disciplines of Imaging and Paediatrics and Child Health, Sydney Medical School, Sydney, NSW (Australia)

    2014-04-15

    Current understanding of cerebral FDG uptake during childhood originates from a small number of studies in patients with neurological abnormalities. Our aim was to describe cerebral FDG uptake in a dataset of FDG PET scans in children more likely to represent a normal population. We reviewed cerebral FDG PET scans in children up to 16 years of age with suspected/proven extracranial malignancies and the following exclusions: central nervous system metastases, previous malignancies, previous chemotherapy or radiotherapy, development of cerebral metastases during therapy, neurological conditions, taking antiepileptic medication or medications likely to interfere with cerebral metabolism, and general anaesthesia within 24 h. White matter, basal ganglia, thalamus and the cerebellar cortex were analysed using regional SUV{sub max}, and the cerebral cortex, basal ganglia, thalamus and cerebellum were analysed using a regional relative uptake analysis in comparison to maximal cortical uptake. Scans from 30 patients (age range 11 months to 16 years, mean age 10 years 5 months) were included. All regions showed increasing SUV{sub max} with age. The parietal, occipital, lateral temporal and medial temporal lobes showed lower rates of increasing FDG uptake causing changing patterns of regional FDG uptake during childhood. The cortical regions showing the most intense uptake in early childhood were the parietal and occipital lobes. At approximately 7 years of age these regions had relatively less uptake than the frontal lobes and at approximately 10 years of age these regions had relatively less uptake than the thalamus. Relative FDG uptake in the brain has not reached an adult pattern by 1 year of age, but continues to change up to 16 years of age. The changing pattern is due to different regional rates of increasing cortical FDG uptake, which is less rapid in the parietal, occipital and temporal lobes than in the frontal lobes. (orig.)

  20. Middle cerebral artery blood velocity during running

    DEFF Research Database (Denmark)

    Lyngeraa, Tobias; Pedersen, Lars Møller; Mantoni, T

    2013-01-01

    for eight subjects, respectively, were excluded from analysis because of insufficient signal quality. Running increased mean arterial pressure and mean MCA velocity and induced rhythmic oscillations in BP and in MCA velocity corresponding to the difference between step rate and heart rate (HR) frequencies....... During running, rhythmic oscillations in arterial BP induced by interference between HR and step frequency impact on cerebral blood velocity. For the exercise as a whole, average MCA velocity becomes elevated. These results suggest that running not only induces an increase in regional cerebral blood flow...

  1. Cerebral angiographic findings in thromboangiitis obliterans

    International Nuclear Information System (INIS)

    No, Young J.; Lee, Eun M.; Kim, Jong S.; Lee, Deok H.

    2005-01-01

    Transient ischemic attacks (TIAs) or ischemic stroke may complicate thromboangiitis obliterans (TAO). However, there has been debate regarding the mechanism of ischemic stroke in TAO. We report the case of a patient with TAO who developed repeated TIAs. An angiogram showed multiple alternative areas of arterial occlusions in the distal segments of both middle cerebral arteries. Extensive collateral vessels around the occluded segment were also observed, which resembled the ''tree root'' or ''corkscrew'' vessels described in the peripheral arteries in TAO. Our patient illustrates that cerebral manifestations of TAO may occur with vascular changes that are identical with those encountered in the limb arteries in TAO. (orig.)

  2. Functional stability of cerebral circulatory system

    Science.gov (United States)

    Moskalenko, Y. Y.

    1980-01-01

    The functional stability of the cerebral circulation system seems to be based on the active mechanisms and on those stemming from specific of the biophysical structure of the system under study. This latter parameter has some relevant criteria for its quantitative estimation. The data obtained suggest that the essential part of the mechanism for active responses of cerebral vessels which maintains the functional stability of this portion of the vascular system, consists of a neurogenic component involving central nervous structures localized, for instance, in the medulla oblongata.

  3. Maternal Infections during Pregnancy and Cerebral Palsy

    DEFF Research Database (Denmark)

    Miller, Jessica; Pedersen, Lars Henning; Streja, Elani

    2013-01-01

    BACKGROUND: Cerebral palsy (CP) is a common motor disability in childhood. We examined the association between maternal infections during pregnancy and the risk of congenital CP in the child. METHODS: Liveborn singletons in Denmark between 1997 and 2003 were identified from the Danish National...... the Danish Cerebral Palsy Registry. Adjusted hazard ratio (HR) and 95% confidence interval (CI) were estimated by Cox proportional hazard models. RESULTS: Of the 440 564 singletons with follow-up data, 840 were diagnosed with congenital CP. Maternal genito-urinary tract infections (HR 2.1, 95% CI 1.4, 3...

  4. Epidemiology of cerebral palsy in Southern Denmark

    DEFF Research Database (Denmark)

    Frøslev-Friis, Christina; Dunkhase-Heinl, Ulrike; Andersen, Johnny Dohn Holmgren

    2015-01-01

    INTRODUCTION: The aim of this study was to describe the prevalence, subtypes, severity and neuroimaging findings of cerebral palsy (CP) in a cohort of children born in Southern Denmark. Risk factors were analysed and aetiology considered. METHODS: A population-based cohort study covering 17...... prevention of CP is possible if the numbers of preterm births and multiple pregnancies can be reduced. FUNDING: The Danish Cerebral Palsy Follow-up Programme is supported by the foundation "Ludvig og Sara Elsass Fond". TRIAL REGISTRATION: 2008-58-0034....

  5. Progressive cerebral atrophy in neuromyelitis optica.

    Science.gov (United States)

    Warabi, Yoko; Takahashi, Toshiyuki; Isozaki, Eiji

    2015-12-01

    We report two cases of neuromyelitis optica patients with progressive cerebral atrophy. The patients exhibited characteristic clinical features, including elderly onset, secondary progressive tetraparesis and cognitive impairment, abnormally elevated CSF protein and myelin basic protein levels, and extremely highly elevated serum anti-AQP-4 antibody titer. Because neuromyelitis optica pathology cannot switch from an inflammatory phase to the degenerative phase until the terminal phase, neuromyelitis optica rarely appears as a secondary progressive clinical course caused by axonal degeneration. However, severe intrathecal inflammation and massive destruction of neuroglia could cause a secondary progressive clinical course associated with cerebral atrophy in neuromyelitis optica patients. © The Author(s), 2015.

  6. Pathophysiology of muscle contractures in cerebral palsy.

    Science.gov (United States)

    Mathewson, Margie A; Lieber, Richard L

    2015-02-01

    Patients with cerebral palsy present with a variety of adaptations to muscle structure and function. These pathophysiologic symptoms include functional deficits such as decreased force production and range of motion, in addition to changes in muscle structure such as decreased muscle belly size, increased sarcomere length, and altered extracellular matrix structure and composition. On a cellular level, patients with cerebral palsy have fewer muscle stem cells, termed satellite cells, and altered gene expression. Understanding the nature of these changes may present opportunities for the development of new muscle treatment therapies. Published by Elsevier Inc.

  7. Reversible cerebral vasconstriction syndrome: A case report

    International Nuclear Information System (INIS)

    Lee, Jeong Sub; Park, Ji Kang; Kim, Seung Hyoung; Jeong, Sun Young

    2013-01-01

    We report a 46-year-old woman patient with reversible cerebral vasoconstriction syndrome (RCVS). She presented with severe headache, multiple cerebral infarction, and multifocal severe stenosis in the intracranial arteries on magnetic resonance angiography (MRA). One month after the episode, a small bowel gastrointestinal stromal tumor (GIST) was incidentally detected during the evaluation of severe anemia and GIST was removed. Follow-up MRA was performed 3 months and 1 year after an initial attack of headache, and multifocal severe intracranial arterial stenotic lesions were completely resolved, she did not experience any episode of RCVS during the 2 years.

  8. Cerebral blood flow changes in cluster headache

    International Nuclear Information System (INIS)

    Norris, J.W.; Hachinski, V.C.; Cooper, P.W.

    1976-01-01

    Serial cerebral blood flod studies performed by the intra-carotid 133 Xenon method were fortuitously determined during the course of a cluster headache in a 32 year old man. The initial study was performed about 10 min after the headache began and showed values at the upper limit of normal. Twenty min after the headache started a second procedure showed that the autoregulatory response on hyperventilation was normal. Ergotamine tartrate was given intra-muscularly 23 min after the headache began and there was partial relief. A third cerebral blood flow estimation showed abnormally high values. The probable reasons for this are discussed. (author)

  9. Cerebral blood flow and metabolism during sleep

    DEFF Research Database (Denmark)

    Madsen, Peter Lund; Vorstrup, S

    1991-01-01

    A review of the current literature regarding sleep-induced changes in cerebral blood flow (CBF) and cerebral metabolic rate (CMR) is presented. Early investigations have led to the notion that dreamless sleep was characterized by global values of CBF and CMR practically at the level of wakefulness......, while rapid eye movement (REM) sleep (dream sleep) was a state characterized by a dramatically increased level of CBF and possibly also of CMR. However, recent investigations firmly contradict this notion. Investigations on CBF and CMR performed during non-REM sleep, taking the effect of different...... current state identify the physiological processes involved in sleep or the physiological role of sleep....

  10. CT fogging effect with ischemic cerebral infarcts

    International Nuclear Information System (INIS)

    Becker, H.; Desch, H.; Hacker, H.; Pencz, A.; Frankfurt Univ.

    1979-01-01

    Systematic CT studies on ten patients with persistent ischemic cerebral infarct revealed a constant phenomenon, the fogging effect. The hypodense infarct at the beginning will be isodense, or close to isodense, on the plain CT during the second or third week and at a later stage will be hypodense again. The fogging infarcted area shows homogeneous intensive contrast enhancement. Knowledge of the fogging effect is important for correct interpretation of the CT image and the indication for contrast medium CT. CT without contrast medium may lead to misinterpretation during the second and third week after the onset of cerebral infarction. (orig.) [de

  11. Locations of cerebral infarctions in tuberculous meningitis

    International Nuclear Information System (INIS)

    Hsieh, F.Y.; Chia, L.G.; Shen, W.C.

    1992-01-01

    The locations of cerebral infarctions were studied in 14 patients with tuberculous meningitis (TBM) and 173 patients with noninflammatory ischemic stroke (IS). In patients with TBM, 75% of infarctions occurred in the 'TB zone' supplied by medial striate and thalamoperforating arteries; only 11% occurred in the 'IS zone' supplied by lateral striate, anterior choroidal and thalamogeniculate arteries. In patients with IS, 29% of infarctions occurred in the IS zone, 29% in the subcortical white matter, and 24% in (or involving) the cerebral cortex. Only 11% occurred in the TB zone. Bilaterally symmetrical infarctions of the TB zone were common with TBM (71%) but rare with IS (5%). (orig.)

  12. CT fogging effect with ischemic cerebral infarcts

    Energy Technology Data Exchange (ETDEWEB)

    Becker, H; Desch, H; Hacker, H; Pencz, A [Frankfurt Univ. (Germany, F.R.). Abt. fuer Neurologie; Frankfurt Univ. (Germany, F.R.). Abt. fuer Neuroradiologie)

    1979-01-01

    Systematic CT studies on ten patients with persistent ischemic cerebral infarct revealed a constant phenomenon, the fogging effect. The hypodense infarct at the beginning will be isodense, or close to isodense, on the plain CT during the second or third week and at a later stage will be hypodense again. The fogging infarcted area shows homogeneous intensive contrast enhancement. Knowledge of the fogging effect is important for correct interpretation of the CT image and the indication for contrast medium CT. CT without contrast medium may lead to misinterpretation during the second and third week after the onset of cerebral infarction.

  13. Cerebral radiation necrosis: vascular and glial features

    Energy Technology Data Exchange (ETDEWEB)

    Husain, M M; Garcia, J H

    1976-12-21

    Glial and vascular abnormalities in brain, simulating intracranial neoplasia, are described in a patient who received radiation to the pituitary region for treatment of an adenoma, 13 months before death. In addition to the expected changes of cerebral radionecrosis, four interesting features are cited: (1) diffuse hyperplasia of capillaries in the cerebral cortex with marked endothelial hypertrophy; (2) abundant, large multipolar bizarre cells in the perivascular connective tissues; (3) focal astrocytic proliferation with many cells resembling either Alzheimer type I astrocytes or neoplastic cells, and (4) radiation changes in the non-irradiated brain.

  14. Reversible cerebral vasconstriction syndrome: A case report

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jeong Sub; Park, Ji Kang; Kim, Seung Hyoung; Jeong, Sun Young [Jeju National University Hospital, Jeju National University School of Medicine, Jeju (Korea, Republic of)

    2013-11-15

    We report a 46-year-old woman patient with reversible cerebral vasoconstriction syndrome (RCVS). She presented with severe headache, multiple cerebral infarction, and multifocal severe stenosis in the intracranial arteries on magnetic resonance angiography (MRA). One month after the episode, a small bowel gastrointestinal stromal tumor (GIST) was incidentally detected during the evaluation of severe anemia and GIST was removed. Follow-up MRA was performed 3 months and 1 year after an initial attack of headache, and multifocal severe intracranial arterial stenotic lesions were completely resolved, she did not experience any episode of RCVS during the 2 years.

  15. Modulation of cerebral blood flow with transcutaneous electrical neurostimulation (TENS) in patients with cerebral vasospasm after subarachnoid hemorrhage

    NARCIS (Netherlands)

    ter Laan, Mark; van Dijk, J.M.C.; Stewart, Roy; Staal, Michiel J; Elting, Jan-Willem J.

    ObjectivesTranscutaneous electrical neurostimulation (TENS) and spinal cord stimulation have been shown to increase peripheral and cerebral blood flow. We postulate that certain pathological conditions attenuate cerebral autoregulation, which may result in a relative increase of the importance of

  16. Modulation of cerebral blood flow with transcutaneous electrical neurostimulation (TENS) in patients with cerebral vasospasm after subarachnoid hemorrhage

    NARCIS (Netherlands)

    Laan, M. ter; Dijk, J.M. van; Stewart, R.; Staal, M.J.; Elting, J.W.

    2014-01-01

    OBJECTIVES: Transcutaneous electrical neurostimulation (TENS) and spinal cord stimulation have been shown to increase peripheral and cerebral blood flow. We postulate that certain pathological conditions attenuate cerebral autoregulation, which may result in a relative increase of the importance of

  17. Cerebral cavernous angioma. 16 cases. Aspects in CT and MR

    International Nuclear Information System (INIS)

    Pina, J.I.; Medrano, J.; Lasierra, R.; Benito, J.L. de; Feijoo, R.; Fernandez, J.A.; Villavieja, J.L.

    1995-01-01

    The cerebral cavernous angioma (CA) is included in the group of cerebral malformations that can not be detected angiographically. We present the retrospective study of 16 patients, diagnosed as having CA, comparing the data provided by CT and MR, as well as the contribution of cerebral angiography. (Author) 25 refs

  18. Radiologic manifestations of focal cerebral hyperemia in acute stroke

    DEFF Research Database (Denmark)

    Olsen, Tom Skyhøj; Skriver, E B; Herning, M

    1991-01-01

    In 16 acute stroke patients with focal cerebral hyperemia angiography and regional cerebral blood flow (rCBF) were studied 1 to 4 days post stroke. CT was performed twice with and without contrast enhancement 3 +/- 1 days and 16 +/- 4 days post stroke. Angiographic evidence of focal cerebral hype...

  19. Risk Factors For Epilepsy In Children With Cerebral Palsy | Lagunju ...

    African Journals Online (AJOL)

    Epilepsy is said to occur in 15-90% of children with cerebral palsy and this poses additional economic and psychological stress on affected children and their families. Objectives To describe the risk factors for epilepsy in children with cerebral palsy. Methods One hundred and seventy six children with cerebral palsy seen at ...

  20. Auditory Selective Attention in Cerebral-Palsied Individuals.

    Science.gov (United States)

    Laraway, Lee Ann

    1985-01-01

    To examine differences between auditory selective attention abilities of normal and cerebral-palsied individuals, 23 cerebral-palsied and 23 normal subjects (5-21) were asked to repeat a series of 30 items in presence of intermittent white noise. Results indicated that cerebral-palsied individuals perform significantly more poorly when the…