WorldWideScience

Sample records for del memorial sloan-kettering

  1. A Personal Reflection on the History of Radiation Oncology at Memorial Sloan-Kettering Cancer Center

    International Nuclear Information System (INIS)

    Chu, Florence C.H.

    2011-01-01

    Purpose: To provide a historical and personal narrative of the development of radiation oncology at Memorial Sloan-Kettering Cancer Center (MSKCC), from its founding more than 100 years ago to the present day. Methods and Materials: Historical sources include the Archives of MSKCC, publications by members of MSKCC, the author's personal records and recollections, and her communications with former colleagues, particularly Dr. Basil Hilaris, Dr. Zvi Fuks, and Dr. Beryl McCormick. Conclusions: The author, who spent 38 years at MSKCC, presents the challenges and triumphs of MSKCC's Radiation Oncology Department and details MSKCC's breakthroughs in radiation oncology. She also describes MSKCC's involvement in the founding of the American Society for Therapeutic Radiology and Oncology.

  2. The Memorial Sloan Kettering Cancer Center Recommendations for Prostate Cancer Screening.

    Science.gov (United States)

    Vickers, Andrew J; Eastham, James A; Scardino, Peter T; Lilja, Hans

    2016-05-01

    The Memorial Sloan Kettering Cancer Center (MSKCC) recommendations on prostate cancer screening were developed in response to three limitations of previous screening guidelines: insufficient evidence base, failure to link screening with treatment, and lack of risk stratification. The objective of the recommendations is to provide a schema for prostate cancer screening that maximizes the benefits, in terms of reduction in prostate cancer-specific mortality, and minimizes the harms, in terms of overdiagnosis and overtreatment. We recommend the following schema for men choosing to be screened following informed decision-making: starting at age 45, prostate-specific antigen (PSA) without digital rectal examination. If PSA ≥ 3 ng/mL: consider prostate biopsy; if PSA ≥ 1 but decision to biopsy a man with a PSA > 3 ng/mL should be based on a variety of factors including repeat blood draw for confirmatory testing of the PSA level, digital rectal examination results, and workup for benign disease. Additional reflex tests in blood such as a free-to-total PSA ratio, the Prostate Health Index, or 4Kscore, or urinary testing of PCA3, can also be informative in some patients. The best evidence suggests that more restricted indication for prostate biopsy and a more focused approach to pursue screening in men at highest risk of lethal cancer would retain most of the mortality benefits of aggressive screening schema, while importantly reducing harms from overdetection and overtreatment. Copyright © 2016 Elsevier Inc. All rights reserved.

  3. Is the Memorial Sloan Kettering Cancer Centre (MSKCC) sarcoma nomogram useful in an Asian population?

    Science.gov (United States)

    Ng, Deanna Wan Jie; Tan, Grace Hwei Ching; Chia, Claramae Shulyn; Lim, Cindy Xindi; Chee, Soo Khee; Quek, Richard Hong Hui; Farid, Mohamad; Teo, Melissa Ching Ching

    2017-10-01

    A nomogram for prediction of 12-year sarcoma-specific survival has been developed based on patients with soft tissue sarcomas treated in Memorial Sloan Kettering Cancer Centre (MSKCC). We aim to evaluate the predictive accuracy of the MSKCC sarcoma nomogram in a cohort of patients treated at an Asian institution. This has not been validated in an Asian population and thus its universal applicability remains unproven. Between 1990 and 2013, 840 adult patients underwent treatment for primary soft tissue sarcoma (STS) at the National Cancer Centre Singapore. Patients who presented with locally recurrent or metastatic disease were excluded from the analysis. The variables included in the MSKCC nomogram included age at diagnosis, tumor size, histologic grade, histologic subtype, depth and site. A total of 399 patients were left for analysis. The nomogram was validated by assessing its extent of discrimination and level of calibration. All patients had deep tumors. Disease occurred most commonly in the lower extremity (n = 149 [37.3%]), the most common histologic subtype was "Others" (angiosarcoma, ewing's sarcoma, endometrial stromal sarcoma, sarcoma NOS [not otherwise specified] and rhabdomyosarcoma). Sixty-four percent of all patients had high-grade tumors while 36% had low-grade tumors. The median patient age at diagnosis was 54 years (range: 17-88 years). The median follow up time for all patients and surviving patients were 29 (range: 1-174) and 33 (range: 1-157) months, respectively. The observed 5- and 10-year sarcoma-specific survival were 55% and 33%, respectively. The concordance index was 0.71. For level of calibration, the observed correspondence between predicted and actual outcomes suggest that the MSKCC nomogram generally predicts well for patients with higher survival probability, but consistently overpredicts survival for the other groups, in our cohort of patients. The MSKCC sarcoma nomogram was found to be accurate in terms of extent of discrimination

  4. Building a CAR Garage: Preparing for the Delivery of Commercial CAR T Cell Products at Memorial Sloan Kettering Cancer Center.

    Science.gov (United States)

    Perica, Karlo; Curran, Kevin J; Brentjens, Renier J; Giralt, Sergio A

    2018-03-01

    Two commercial chimeric antigen receptor (CAR) T cell therapies for CD19-expressing B cell malignancies, Kymriah and Yescarta, have recently been approved by the Food and Drug Administration. The administration of CAR T cells is a complex endeavor involving cell manufacture, tracking and shipping of apheresis products, and management of novel and severe toxicities. At Memorial Sloan Kettering Cancer Center, we have identified 8 essential tasks that define the CAR T cell workflow. In this review, we discuss practical aspects of CAR T cell program development, including clinical, administrative, and regulatory challenges for successful implementation. Copyright © 2018 The American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.

  5. Risk factors for bowel dysfunction after sphincter-preserving rectal cancer surgery: a prospective study using the Memorial Sloan Kettering Cancer Center bowel function instrument.

    Science.gov (United States)

    Ihn, Myong Hoon; Kang, Sung-Bum; Kim, Duck-Woo; Oh, Heung-Kwon; Lee, Soo Young; Hong, Sa Min

    2014-08-01

    Until recently, no studies have prospectively evaluated bowel function after sphincter-preserving surgery for rectal cancer with the use of a validated bowel function scoring system. The aim of this study was to investigate possible risk factors for altered bowel function after sphincter-preserving surgery. This was a prospective study. The study was conducted between January 2006 and May 2012 at the authors' institution. Patients who underwent sphincter-preserving rectal cancer surgery were recruited. Bowel function was assessed 1 day before (baseline) and at 1 year after sphincter-preserving surgery or temporary ileostomy takedown with the use of the Memorial Sloan Kettering Cancer Center questionnaire. Multivariable analysis was performed to identify the factors associated with altered bowel function after surgery. Overall, 266 patients were eligible for the analysis. The tumor was located in the upper, middle, and lower rectum in 68 (25.5%), 113 (42.5%), and 85 (32.0%) patients. Intersphincteric resection and temporary ileostomy were performed in 18 (6.8%) and 129 (48.5%) patients. The mean Memorial Sloan Kettering Cancer Center score was 64.5 ± 7.6 at 1 year after sphincter-preserving surgery or temporary ileostomy takedown. The Memorial Sloan Kettering Cancer Center score decreased in 163/266 patients (61.3%) between baseline and 1 year after surgery. Tumor location (p = 0.01), operative method (p = 0.03), anastomotic type (p = 0.01), and temporary ileostomy (p = 0.01) were associated with altered bowel function after sphincter-preserving surgery in univariate analyses. In multivariable analysis, only tumor location was independently associated with impaired bowel function after sphincter-preserving rectal cancer surgery. This study was limited by its nonrandomized design and the lack of measurement before preoperative chemoradiotherapy. We suggest that preoperative counseling should be implemented to inform patients of the risk of bowel dysfunction

  6. Prognostic stratification of patients with advanced renal cell carcinoma treated with sunitinib: comparison with the Memorial Sloan-Kettering prognostic factors model

    International Nuclear Information System (INIS)

    Bamias, Aristotelis; Anastasiou, Ioannis; Stravodimos, Kostas; Xanthakis, Ioannis; Skolarikos, Andreas; Christodoulou, Christos; Syrigos, Kostas; Papandreou, Christos; Razi, Evangelia; Dafni, Urania; Fountzilas, George; Karadimou, Alexandra; Dimopoulos, Meletios A; Lampaki, Sofia; Lainakis, George; Malettou, Lia; Timotheadou, Eleni; Papazisis, Kostas; Andreadis, Charalambos; Kontovinis, Loukas

    2010-01-01

    The treatment paradigm in advanced renal cell carcinoma (RCC) has changed in the recent years. Sunitinib has been established as a new standard for first-line therapy. We studied the prognostic significance of baseline characteristics and we compared the risk stratification with the established Memorial Sloan Kettering Cancer Center (MSKCC) model. This is a retrospective analysis of patients treated in six Greek Oncology Units of HECOG. Inclusion criteria were: advanced renal cell carcinoma not amenable to surgery and treatment with Sunitinib. Previous cytokine therapy but no targeted agents were allowed. Overall survival (OS) was the major end point. Significance of prognostic factors was evaluated with multivariate cox regression analysis. A model was developed to stratify patients according to risk. One hundred and nine patients were included. Median follow up has been 15.8 months and median OS 17.1 months (95% CI: 13.7-20.6). Time from diagnosis to the start of Sunitinib (<= 12 months vs. >12 months, p = 0.001), number of metastatic sites (1 vs. >1, p = 0.003) and performance status (PS) (<= 1 vs >1, p = 0.001) were independently associated with OS. Stratification in two risk groups ('low' risk: 0 or 1 risk factors; 'high' risk: 2 or 3 risk factors) resulted in distinctly different OS (median not reached [NR] vs. 10.8 [95% confidence interval (CI): 8.3-13.3], p < 0.001). The application of the MSKCC risk criteria resulted in stratification into 3 groups (low and intermediate and poor risk) with distinctly different prognosis underlying its validity. Nevertheless, MSKCC model did not show an improved prognostic performance over the model developed by this analysis. Studies on risk stratification of patients with advanced RCC treated with targeted therapies are warranted. Our results suggest that a simpler than the MSKCC model can be developed. Such models should be further validated

  7. Intensity-Modulated Radiotherapy in the Treatment of Oropharyngeal Cancer: An Update of the Memorial Sloan-Kettering Cancer Center Experience

    Energy Technology Data Exchange (ETDEWEB)

    Setton, Jeremy; Caria, Nicola; Romanyshyn, Jonathan; Koutcher, Lawrence; Wolden, Suzanne L.; Zelefsky, Michael J.; Rowan, Nicholas [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY (United States); Sherman, Eric J.; Fury, Matthew G.; Pfister, David G. [Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY (United States); Wong, Richard J.; Shah, Jatin P.; Kraus, Dennis H. [Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY (United States); Shi Weiji; Zhang Zhigang [Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY (United States); Schupak, Karen D.; Gelblum, Daphna Y.; Rao, Shyam D. [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY (United States); Lee, Nancy Y., E-mail: Leen2@mskcc.org [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY (United States)

    2012-01-01

    Purpose: To update the Memorial Sloan-Kettering Cancer Center's experience with intensity-modulated radiotherapy (IMRT) in the treatment of oropharyngeal cancer (OPC). Methods and Materials: Between September 1998 and April 2009, 442 patients with histologically confirmed OPC underwent IMRT at our center. There were 379 men and 63 women with a median age of 57 years (range, 27-91). The disease was Stage I in 2%, Stage II in 4%, Stage III in 21%, and Stage IV in 73% of patients. The primary tumor subsite was tonsil in 50%, base of tongue in 46%, pharyngeal wall in 3%, and soft palate in 2%. The median prescription dose to the planning target volume of the gross tumor was 70 Gy for definitive (n = 412) cases and 66 Gy for postoperative cases (n = 30). A total 404 patients (91%) received chemotherapy, including 389 (88%) who received concurrent chemotherapy, the majority of which was platinum-based. Results: Median follow-up among surviving patients was 36.8 months (range, 3-135). The 3-year cumulative incidence of local failure, regional failure, and distant metastasis was 5.4%, 5.6%, and 12.5%, respectively. The 3-year OS rate was 84.9%. The incidence of late dysphagia and late xerostomia {>=}Grade 2 was 11% and 29%, respectively. Conclusions: Our results confirm the feasibility of IMRT in achieving excellent locoregional control and low rates of xerostomia. According to our knowledge, this study is the largest report of patients treated with IMRT for OPC.

  8. Intensity-Modulated Radiotherapy in the Treatment of Oropharyngeal Cancer: An Update of the Memorial Sloan-Kettering Cancer Center Experience

    International Nuclear Information System (INIS)

    Setton, Jeremy; Caria, Nicola; Romanyshyn, Jonathan; Koutcher, Lawrence; Wolden, Suzanne L.; Zelefsky, Michael J.; Rowan, Nicholas; Sherman, Eric J.; Fury, Matthew G.; Pfister, David G.; Wong, Richard J.; Shah, Jatin P.; Kraus, Dennis H.; Shi Weiji; Zhang Zhigang; Schupak, Karen D.; Gelblum, Daphna Y.; Rao, Shyam D.; Lee, Nancy Y.

    2012-01-01

    Purpose: To update the Memorial Sloan-Kettering Cancer Center’s experience with intensity-modulated radiotherapy (IMRT) in the treatment of oropharyngeal cancer (OPC). Methods and Materials: Between September 1998 and April 2009, 442 patients with histologically confirmed OPC underwent IMRT at our center. There were 379 men and 63 women with a median age of 57 years (range, 27–91). The disease was Stage I in 2%, Stage II in 4%, Stage III in 21%, and Stage IV in 73% of patients. The primary tumor subsite was tonsil in 50%, base of tongue in 46%, pharyngeal wall in 3%, and soft palate in 2%. The median prescription dose to the planning target volume of the gross tumor was 70 Gy for definitive (n = 412) cases and 66 Gy for postoperative cases (n = 30). A total 404 patients (91%) received chemotherapy, including 389 (88%) who received concurrent chemotherapy, the majority of which was platinum-based. Results: Median follow-up among surviving patients was 36.8 months (range, 3–135). The 3-year cumulative incidence of local failure, regional failure, and distant metastasis was 5.4%, 5.6%, and 12.5%, respectively. The 3-year OS rate was 84.9%. The incidence of late dysphagia and late xerostomia ≥Grade 2 was 11% and 29%, respectively. Conclusions: Our results confirm the feasibility of IMRT in achieving excellent locoregional control and low rates of xerostomia. According to our knowledge, this study is the largest report of patients treated with IMRT for OPC.

  9. Radiation therapy of Kaposi's sarcoma in AIDS: Memorial Sloan-Kettering experience

    International Nuclear Information System (INIS)

    Nisce, L.Z.; Safai, B.

    1985-01-01

    In 1980 the authors reported their experience in the management of Kaposi's sarcoma (KS) affecting elderly men of Jewish or Italian descent. Since the outbreak of KS in 1981 among young male homosexuals with acquired immune deficiency syndrome (AIDS) the KS in the elderly has been subsequently called classical Kaposi's sarcome (CKS) in order to differentiate it from the KS in AIDS. The radiosensitivity of CKS is well documented. This report describes the authors' early experience in the radiation therapy of KS in AIDS compared with CKS and also discusses the problems related to the irradiation of the immunocompromised patient

  10. Radiation therapy for Ewing's sarcoma: Results from Memorial Sloan-Kettering in the modern era

    International Nuclear Information System (INIS)

    La, Trang H.; Meyers, Paul A.; Wexler, Leonard H.; Alektiar, Kaled M.; Healey, John H.; Laquaglia, Michael P.; Boland, Patrick J.; Wolden, Suzanne L.

    2006-01-01

    Purpose: To evaluate the outcomes of patients with Ewing's sarcoma family of tumors (ESFT) treated with modern radiotherapy techniques with MRI along with optimal chemotherapy. Methods and Materials: The records of all 60 patients with ESFT who received radiation to the primary site between 1990 and 2004 were reviewed. All patients received chemotherapy, including vincristine, doxorubicin, cyclophosphamide, ifosfamide, and etoposide. Radiation was used as the sole modality for local control in 31 patients and was given either before (n = 3) or after surgical resection (n = 26) in the remainder. All patients had MRI and CT scan-based treatment planning, and 43% received intensity-modulated radiation therapy. Radiation doses ranged from 30 Gy to 60 Gy (median, 51 Gy), and 35% received hyperfractionated radiotherapy. Results: Median age was 16 years (range, 2-40 years). Because of selection bias for radiotherapy, the majority of primary tumors were centrally located (72%): spine (n = 18), pelvis (n = 15), extremities (n 12), chest wall (n = 5), head and neck (n = 5), and other (n = 5). Thirty-eight percent of patients presented with metastatic disease, and 52% of primary tumors were ≥8 cm. Actuarial 3-year local control was 77%. The presence of metastases at diagnosis was an adverse prognostic factor for local control (84% vs. 61%, p = 0.036). No other predictive factors for local failure were identified. In patients without metastatic disease, 3-year disease-free and overall survival rates were 70% and 86%, respectively, whereas in patients with metastases they were both 21%. Follow-up of surviving patients was 6-178 months (median, 41 months). Conclusion: In this unfavorable cohort of ESFT patients, radiation therapy was an effective modality for local control, especially for patients without metastases. The presence of metastases at diagnosis is a predictive factor not only for death but also for local failure

  11. Development and Assessment of Memorial Sloan Kettering Cancer Center’s Surgical Secondary Events Grading System

    Science.gov (United States)

    Strong, Vivian E.; Selby, Luke V.; Sovel, Mindy; Disa, Joseph J.; Hoskins, William; DeMatteo, Ronald; Scardino, Peter; Jaques, David P.

    2015-01-01

    Background Studying surgical secondary events is an evolving effort with no current established system for database design, standard reporting, or definitions. Using the Clavien-Dindo classification as a guide, in 2001 we developed a Surgical Secondary Events database based on grade of event and required intervention to begin prospectively recording and analyzing all surgical secondary events (SSE). Study Design Events are prospectively entered into the database by attending surgeons, house staff, and research staff. In 2008 we performed a blinded external audit of 1,498 operations that were randomly selected to examine the quality and reliability of the data. Results 1,498 of 4,284 operations during the 3rd quarter of 2008 were audited. 79% (N=1,180) of the operations did not have a secondary event while 21% (N=318) of operations had an identified event. 91% (1,365) of operations were correctly entered into the SSE database. 97% (129/133) of missed secondary events were Grades I and II. Three Grade III (2%) and one Grade IV (1%) secondary event were missed. There were no missed Grade 5 secondary events. Conclusion Grade III – IV events are more accurately collected than Grade I – II events. Robust and accurate secondary events data can be collected by clinicians and research staff and these data can safely be used for quality improvement projects and research. PMID:25319579

  12. The relative value of cytometry and cytology in the management of bladder cancer: the Memorial Sloan-Kettering Cancer Center experience.

    Science.gov (United States)

    Badalament, R A; Fair, W R; Whitmore, W F; Melamed, M R

    1988-02-01

    The flow cytometric studies presented herein are based almost entirely on DNA measurements and represent an early application of this diagnostic test. Nevertheless, the MSKCC experience with FCM has demonstrated that it is technically feasible and clinically useful. The sensitivity of FCM is in the range of 80% to 85% overall, and is superior to that of conventional voided or bladder wash cytology. In the absence of inflammation secondary to infection, calculi, or intravesical agents such as BCG, the specificity is greater than 90%. In the presence of inflammation, FCM appears to be less specific than conventional cytology. A potential advantage of FCM over cytology is the quantitative nature of the examination permitting comparisons of sequential examinations. Also, there are refinements in technique that hold promise of increasing the accuracy or clinical usefulness of FCM, eg, the joint measurements of DNA and differentiation antigens defined by monoclonal antibodies. Yet, despite the current and potential advantages of FCM, voided urinary cytology continues to be the procedure of choice for detection and monitoring urothelial carcinoma, not only because of our long experience and better understanding of this test, but because of its proven high specificity, because it is noninvasive, widely available, and may help to detect upper tract or urethral tumors.

  13. Long-term medical outcomes in survivors of extra-ocular retinoblastoma: the Memorial Sloan-Kettering Cancer Center (MSKCC) experience.

    Science.gov (United States)

    Friedman, Danielle Novetsky; Sklar, Charles A; Oeffinger, Kevin C; Kernan, Nancy A; Khakoo, Yasmin; Marr, Brian P; Wolden, Suzanne L; Abramson, David H; Dunkel, Ira J

    2013-04-01

    Data on long-term outcomes of survivors of extra-ocular retinoblastoma are lacking. The authors sought to provide the first report characterizing long-term outcomes among survivors of extra-ocular retinoblastoma. Retrospective analysis of long-term medical outcomes in 19 survivors of extra-ocular retinoblastoma treated between 1992 and 2009. Severity of outcomes was graded using Common Terminology Criteria for Adverse Events. All patients received intensive multimodality therapy for their extra-ocular disease after management of their primary intra-ocular disease, including conventional chemotherapy (n = 19, 100%), radiotherapy (n = 15, 69%), and/or high-dose chemotherapy with autologous stem cell transplant (n = 17, 89%). The median follow-up was 7.8 years from diagnosis of extra-ocular retinoblastoma (range 2-17.8 years). The most common long-term non-visual outcomes were hearing loss (n = 15, 79%), short stature (n = 7, 37%), and secondary malignancies [SMN] (n = 6, 31%). Sixty-eight percent of survivors exhibited ≥2 non-visual long-term outcomes of any grade. Except short stature, which was not graded for severity, Grade 3-4 outcomes were limited to: ototoxicity (n = 8; n = 4 require hearing aids), SMNs (n = 6), and unequal limb length (n = 1). Five patients who developed SMNs carried a known RB1 mutation. SMNs developed at a median of 11.1 years after initial diagnosis; two patients died of their SMN. Long-term cardiac, pulmonary, hepatobiliary, or renal conditions were not identified in any survivors. Long-term outcomes are commonly seen in extra-ocular retinoblastoma survivors but the majority are mild-moderate in their severity. Longer comprehensive follow-up is needed to fully assess treatment-related outcomes but the information collected to date may affect management decisions for children with extra-ocular disease. Copyright © 2012 Wiley Periodicals, Inc.

  14. Use of positron emission tomography scan response to guide treatment change for locally advanced gastric cancer: the Memorial Sloan Kettering Cancer Center experience.

    Science.gov (United States)

    Won, Elizabeth; Shah, Manish A; Schöder, Heiko; Strong, Vivian E; Coit, Daniel G; Brennan, Murray F; Kelsen, David P; Janjigian, Yelena Y; Tang, Laura H; Capanu, Marinela; Rizk, Nabil P; Allen, Peter J; Bains, Manjit S; Ilson, David H

    2016-08-01

    Early metabolic response on 18-fluorodeoxyglucose-positron emission tomography (FDG-PET) during neoadjuvant chemotherapy is PET non-responders have poor outcomes whether continuing chemotherapy or proceeding directly to surgery. Use of PET may identify early treatment failure, sparing patients from inactive therapy and allowing for crossover to alternative therapies. We examined the effectiveness of PET directed switching to salvage chemotherapy in the PET non-responders. Patients with locally advanced resectable FDG-avid gastric or gastroesophageal junction (GEJ) adenocarcinoma received bevacizumab 15 mg/kg, epirubicin 50 mg/m(2), cisplatin 60 mg/m(2) day 1, and capecitabine 625 mg/m(2) bid (ECX) every 21 days. PET scan was obtained at baseline and after cycle 1. PET responders, (i.e., ≥35% reduction in FDG uptake at the primary tumor) continued ECX + bev. Non-responders switched to docetaxel 30 mg/m(2), irinotecan 50 mg/mg(2) day 1 and 8 plus bevacizumab every 21 days for 2 cycles. Patients then underwent surgery. The primary objective was to improve the 2-year disease free survival (DFS) from 30% (historical control) to 53% in the non-responders. Twenty evaluable patients enrolled before the study closed for poor accrual. Eleven were PET responders and the 9 non-responders switched to the salvage regimen. With a median follow-up of 38.2 months, the 2-year DFS was 55% [95% confidence interval (CI), 30-85%] in responders compared with 56% in the non-responder group (95% CI, 20-80%, P=0.93). The results suggest that changing chemotherapy regimens in PET non-responding patients may improve outcomes. Results from this pilot trial are hypothesis generating and suggest that PET directed neoadjuvant therapy merits evaluation in a larger trial.

  15. In vivo neutron activation at the Sloan-Kettering Institute

    International Nuclear Information System (INIS)

    Bigler, R.E.

    1986-01-01

    A medical cyclotron (Model CS-15, The Cyclotron Corporation, Berkeley, CA) with a multi-layer neutron collimator designed for partial body neutron irradiations and a low-background patient counting facility have been established for measurement of bone calcium and sodium; and soft tissue, exchangeable sodium and chlorine. The cyclotron also provides total-body calcium by the 37 Ar method of Palmer. (author)

  16. 2015 Soft Condensed Matter Physics: Self-Assembly and Active Matter GRC/GRS

    Science.gov (United States)

    2015-10-20

    Broad Institute of MIT and Harvard Poster Presenter Registered Beller, Daniel A Harvard University Poster Presenter Registered Bi, Dapeng Syracuse...Poster Presenter Registered Deforet, Maxime Memorial Sloan Kettering Cancer Center Poster Presenter Registered Del Gado, Emanuela Georgetown...Registered Dullens, Roel University of Oxford Poster Presenter Registered Fakhri, Nikta MIT Poster Presenter Registered Fan, Jing Harvard

  17. 75 FR 9006 - President's Council of Advisors on Science and Technology; Notice of Meeting: Partially Closed...

    Science.gov (United States)

    2010-02-26

    .... Varmus, President, Memorial Sloan-Kettering Cancer Center; and Dr. Eric S. Lander, President and Director, Broad Institute of MIT and Harvard. Meeting Accomodations: Individuals requiring special accommodation...

  18. Putting TCGA Data to Work - TCGA

    Science.gov (United States)

    Neurosurgeon Cameron Brennan of Memorial Sloan-Kettering Cancer Center used TCGA data to define subgroups of patients with a deadly brain cancer called glioblastoma multiforme. Learn more about his research in this TCGA in Action case study.

  19. Electronic Chemotherapy Order Entry: A Major Cancer Center's Implementation

    OpenAIRE

    Sklarin, Nancy T.; Granovsky, Svetlana; O'Reilly, Eileen M.; Zelenetz, Andrew D.

    2011-01-01

    Implementation of computerized provider order entry for complex chemotherapy regimens supported Memorial Sloan-Kettering Cancer Center's strategic plan to successfully establish a distributive, networked health care delivery system.

  20. Validation of a nomogram for predicting survival after resection for adenocarcinoma of the pancreas

    NARCIS (Netherlands)

    de Castro, S. M. M.; Biere, S. S. A. Y.; Lagarde, S. M.; Busch, O. R. C.; van Gulik, T. M.; Gouma, D. J.

    2009-01-01

    Background: Nomograms are statistical tools providing the overall probability of a specific outcome; they have shown better individual discrimination than the tumour node metastasis staging system in several cancers. The pancreatic nomogram, originally developed in the Memorial Sloan-Kettering

  1. 75 FR 22635 - President's Council of Advisors on Science and Technology; Meeting

    Science.gov (United States)

    2010-04-29

    ... President, The White House; Dr. Harold E. Varmus, President, Memorial Sloan-Kettering Cancer Center; and Dr. Eric S. Lander, President and Director, Broad Institute of MIT and Harvard. Meeting Accomodations...

  2. Characterization of newly established colorectal cancer cell lines ...

    Indian Academy of Sciences (India)

    Unknown

    2000-12-19

    Dec 19, 2000 ... ... Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA .... with biotinylated horse anti-mouse IgG (Vector Labora- ...... development of new therapies or prognosis of the disease,.

  3. Genetic and Epigenetic Determinants of Lung Cancer Subtype: Adenocarcinoma to Small Cell Conversion

    Science.gov (United States)

    2015-08-01

    have obtained full IRB approval for this study at both the primary sites, Memorial Sloan Kettering Cancer Center (MSKCC) and Dana Farber Cancer...California, The University of Copenhagen, Fox Chase Cancer Center, Johns Hopkins University, and Memorial Sloan Kettering. (NEW...sequencer to generate paired-end colour space reads (50 nucleotides forward and 35 nucleotides reverse) by a multiplexed operation. The colour -space

  4. Differentiated thyroid cancer: reclassification of the risk of recurrence based on the response to initial treatment; Carcinoma diferenciado de tiroides: reclasificación del riesgo de recurrencia según la respuesta al tratamiento inicial

    Energy Technology Data Exchange (ETDEWEB)

    Martínez, M. P.; Lozano Bullrich, M. P.; Rey, M.; Ridruejo, M. C.; Bomarito, M. J.; Claus Hermberg, H.; Pozzo, M.J., E-mail: mpazmartinez@yahoo.com [Hospital Alemán, Servicio de Endocrinología, Buenos Aires (Argentina)

    2014-07-01

    response was observed in 11 (84.6 %) and an acceptable response was observed in 2 (15.4 %) of the intermediate-risk classified patients and in the high-risk group 1 patient (100 %) presented an acceptable response. Clinical status of patients after 2 years of IT: 25 (80.6 %) with no evidence of disease (NED), 6 (19.4 %) with biochemical persistence (BP) and 0 (0 %) with structural persistence (EP), recurrence (R) or death (D). After a mean long-term follow-up period of 51.3 months, the clinical status was: 25 (80.6 %) with NED, 4 (12.9 %) with BP and (0 %) with EP, R or D; for the remaining 2 (6.5 %) no long-term follow-up data was available (ND). At the end of the long-term follow-up period, 24 (96 %) patients with excellent response after 2 years of IT remained NED, whereas 1 (4 %) was reported as ND and 1 (16.7 %) patient with acceptable response after 2 years of IT remained NED (initially this was a low-risk patient), 4 (66.6 %) remained BP, 1 (16.7 %) was reported as ND and no EP, R or D was observed. Conclusions: 1) reclassification of patients was particularly useful in the intermediate risk group because 84.6 % of these patients had an excellent response after two years of IT, 2) reclassification of patients based on the response to IT, allows us to optimize their follow-up and 3) although the mean long-term follow-up period was 51.3 months, there was a good correlation between clinical status after two years of IT and after the long-term follow-up period, mainly in the excellent response group. (authors) [Spanish] Introducción: la clasificación de la American Thyroid Association (ATA) para carcinoma diferenciado de tiroides (CDT) aporta una visión estática del paciente al inicio y no está diseñada para ser modificada. El Memorial Sloan-Kettering Cancer Center (MS-KCC) diseñó una reclasificación a 2 años del tratamiento inicial (TI), permitiendo tener una óptica más dinámica. Objetivo: comunicar nuestra experiencia con la reclasificación del riesgo de

  5. WE-A-207-01: Memorial Lecturer

    International Nuclear Information System (INIS)

    Muller-Runkel, R

    2015-01-01

    The Medical Physics community lost one of its early pioneers in radiation oncology physics, Jacques Ovadia, who passed away in April of 2014 at the age of 90. Jacques received his Ph.D. in Nuclear Physics from the University of Illinois at Urbana in 1951. Subsequently, under the guidance of John Laughlin, he was introduced to the field of Medical Physics. When John moved to Memorial Sloan Kettering, Jacques followed him. There he gained clinical experience and expertise in the then cutting-edge field of high energy electron beam therapy. In 1956, Jacques joined Dr. Erich Uhlmann at Michael Reese Hospital in Chicago where one of the country’s first high energy medical linear accelerators had just been installed. During his 35 year tenure, Dr. Ovadia built a strong Medical Physics department that merged in 1984 with that of the University of Chicago. Jacques pioneered the use of high energy electron beams to treat deep seated tumors, multiple-field chest wall irradiation with variable electron energies, and even anticipated the current interest in high energy electron beam grid-therapy. At an early stage, he introduced a simulator, computerized treatment planning and in-house developed record and verify software. He retired in 1990 as Professor emeritus in Radiation and Cellular Biology at the University of Chicago. Dr. Ovadia was an early and strong supporter of AAPM. He was present at the Chicago ROMPS meeting where the decision was made to form an independent professional society for medical physics. He served as AAPM president in 1976. Jacques Ovadia is survived by his wife of 58 years, Florence, their daughter Corinne Graefe and son Marc Ovadia, MD, as well as four grandchildren and one great-grandchild. Jacques’ dynamic and ever enthusiastic personality inspired all who collaborated with him. He will be greatly missed

  6. WE-A-207-01: Memorial Lecturer

    Energy Technology Data Exchange (ETDEWEB)

    Muller-Runkel, R [St. Margaret Mercy Healthcare Centers, Hammond, IN (United States)

    2015-06-15

    The Medical Physics community lost one of its early pioneers in radiation oncology physics, Jacques Ovadia, who passed away in April of 2014 at the age of 90. Jacques received his Ph.D. in Nuclear Physics from the University of Illinois at Urbana in 1951. Subsequently, under the guidance of John Laughlin, he was introduced to the field of Medical Physics. When John moved to Memorial Sloan Kettering, Jacques followed him. There he gained clinical experience and expertise in the then cutting-edge field of high energy electron beam therapy. In 1956, Jacques joined Dr. Erich Uhlmann at Michael Reese Hospital in Chicago where one of the country’s first high energy medical linear accelerators had just been installed. During his 35 year tenure, Dr. Ovadia built a strong Medical Physics department that merged in 1984 with that of the University of Chicago. Jacques pioneered the use of high energy electron beams to treat deep seated tumors, multiple-field chest wall irradiation with variable electron energies, and even anticipated the current interest in high energy electron beam grid-therapy. At an early stage, he introduced a simulator, computerized treatment planning and in-house developed record and verify software. He retired in 1990 as Professor emeritus in Radiation and Cellular Biology at the University of Chicago. Dr. Ovadia was an early and strong supporter of AAPM. He was present at the Chicago ROMPS meeting where the decision was made to form an independent professional society for medical physics. He served as AAPM president in 1976. Jacques Ovadia is survived by his wife of 58 years, Florence, their daughter Corinne Graefe and son Marc Ovadia, MD, as well as four grandchildren and one great-grandchild. Jacques’ dynamic and ever enthusiastic personality inspired all who collaborated with him. He will be greatly missed.

  7. CheckMate 025 Randomized Phase 3 Study: Outcomes by Key Baseline Factors and Prior Therapy for Nivolumab Versus Everolimus in Advanced Renal Cell Carcinoma

    DEFF Research Database (Denmark)

    Escudier, Bernard; Sharma, Padmanee; McDermott, David F

    2017-01-01

    /kg every 2 wk or everolimus 10mg once daily. RESULTS AND LIMITATIONS: The minimum follow-up was 14 mo. Baseline subgroup distributions were balanced between nivolumab and everolimus arms. Nivolumab demonstrated an OS improvement versus everolimus across subgroups, including Memorial Sloan Kettering Cancer...... Center (MSKCC) and International Metastatic Renal Cell Carcinoma Database Consortium risk groups; age

  8. Bringing Precision Medicine to Community Oncologists.

    Science.gov (United States)

    2017-01-01

    Quest Diagnostics has teamed up with Memorial Sloan Kettering Cancer Center and IBM Watson Health to offer IBM Watson Genomics to its network of community cancer centers and hospitals. This new service aims to advance precision medicine by combining genomic tumor sequencing with the power of cognitive computing. ©2017 American Association for Cancer Research.

  9. Development of Medical Technology for Contingency Response to Marrow Toxic Agents

    Science.gov (United States)

    2014-05-06

    Specific Oligonucleotides SSP Sequence Specific Primers SSOP Sequence Specific Oligonucleotide Probes STAR ® Search, Tracking and Registry TBI Total... white paper detailing recommendations/guidelines for the assessment of new assays (potency or other assays) relevant to cord blood banking and/or...Irradiation - Marcel van den Brink (Memorial Sloan Kettering Cancer Center) 5. Organ Toxicity: h. Pulmonary Toxicity - Zeljko Vujaskovic (Duke) i

  10. History of International Workshop on Mini-Micro- and Nano- Dosimetry (MMND) and Innovation Technologies in Radiation Oncology (ITRO)

    Science.gov (United States)

    Rosenfeld, Anatoly B.; Zaider, Marco; Yamada, Josh; Zelefsky, Michael J.

    2017-01-01

    The biannual MMND (former MMD) - IPCT workshops was founded in collaboration between the Centre for Medical Radiation Physics, University of Wollongong and the Memorial Sloan Kettering Cancer Center (MSKCC) in 2001 and has become an important international multidisciplinary forum for the discussion of advanced quality assurance (QA) dosimetry technology for radiation therapy and space science, as well as advanced technologies for clinical cancer treatment.

  11. Cabozantinib versus everolimus in advanced renal cell carcinoma (METEOR): final results from a randomised, open-label, phase 3 trial

    DEFF Research Database (Denmark)

    Choueiri, Toni K; Escudier, Bernard; Powles, Thomas

    2016-01-01

    Memorial Sloan Kettering Cancer Center risk group and the number of previous treatments with VEGFR tyrosine-kinase inhibitors. The primary endpoint was progression-free survival as assessed by an independent radiology review committee in the first 375 randomly assigned patients and has been previously...

  12. Memory

    Science.gov (United States)

    ... it has to decide what is worth remembering. Memory is the process of storing and then remembering this information. There are different types of memory. Short-term memory stores information for a few ...

  13. Novel Approaches to Locoregional and Systemic Immunotherapy for Ovarian Cancer

    Science.gov (United States)

    2017-10-01

    AWARD NUMBER: W81XWH-16-1-0298 TITLE: Novel approaches to locoregional and systemic immunotherapy for ovarian cancer PRINCIPAL INVESTIGATOR...Dmitriy Zamarin CONTRACTING ORGANIZATION: Memorial Sloan Kettering Cancer Center New York, NY 10017 REPORT DATE: October 2017 TYPE OF REPORT...TITLE AND SUBTITLE Novel approaches to locoregional and systemic immunotherapy for ovarian cancer 5a. CONTRACT NUMBER vel ap roaches to l c regional

  14. Integrated irradiation and cystectomy for bladder cancer

    International Nuclear Information System (INIS)

    Whitmore, W.F. Jr.

    1980-01-01

    Planned pre-operative irradiation and cystectomy for selected patients with bladder cancer was initiated approximately 20 years ago by a number of centres on the basis of the disappointing end results of treatment of bladder cancer by either irradiation or surgery and the empirical hope that the combination might lead to better results. This is a brief review of the logical basis for integrated treatment and of the Memorial Sloan-Kettering Cancer Center (MSKCC) experience with such therapy. (author)

  15. Impact of immune parameters on long-term survival in metastatic renal cell      carcinoma

    DEFF Research Database (Denmark)

    Donskov, Frede; Maase, Hans von der

    2006-01-01

    with estimated       5-year survival rates of 60%, 25%, and 0%, respectively. These findings       were apparent in both our own prognostic model and in an extended Memorial       Sloan-Kettering Cancer Center (New York, NY) prognostic model. CONCLUSION:       This study points on five clinical and three...

  16. “Idea del siglo XVIII”: sobre la Ilustración en el Memorial Literario (1801

    Directory of Open Access Journals (Sweden)

    Checa Beltrán, José

    2009-12-01

    Full Text Available Published in Memorial Literario in 1801, Idea del siglo XVIII is a text which has virtually gone unnoticed for most of the scholars of the 18th century, in spite of its great interest. It is one of the first glances cast by the newly welcomed 19th century at the former «Enlightenment century», according to the author’s denomination (presumably, Pedro Maria Olive. The objective of this work is to release this important and early Spanish text about the Enlightenment and study it as the mirror and the lamp of the discussions and controversies of the political, literary and cultural scene of Spain in 1801.Publicado en el Memorial Literario de 1801, la Idea del siglo XVIII es un texto que ha pasado prácticamente desapercibido para la generalidad de los dieciochistas, a pesar de su enorme interés. Constituye una de las primerísimas miradas que el recién inaugurado siglo XIX dirige sobre la centuria anterior, el «siglo ilustrado», como lo denomina el propio autor (presumiblemente Pedro María Olive. El objetivo de este trabajo es dar a conocer este importante y temprano texto español sobre la Ilustración y estudiarlo como espejo y lámpara de los debates y controversias del panorama político, literario y cultural de la España de 1801.

  17. Memory

    OpenAIRE

    Wager, Nadia

    2017-01-01

    This chapter will explore a response to traumatic victimisation which has divided the opinions of psychologists at an exponential rate. We will be examining amnesia for memories of childhood sexual abuse and the potential to recover these memories in adulthood. Whilst this phenomenon is generally accepted in clinical circles, it is seen as highly contentious amongst research psychologists, particularly experimental cognitive psychologists. The chapter will begin with a real case study of a wo...

  18. Memories.

    Science.gov (United States)

    Brand, Judith, Ed.

    1998-01-01

    This theme issue of the journal "Exploring" covers the topic of "memories" and describes an exhibition at San Francisco's Exploratorium that ran from May 22, 1998 through January 1999 and that contained over 40 hands-on exhibits, demonstrations, artworks, images, sounds, smells, and tastes that demonstrated and depicted the biological,…

  19. Fattori di organizzazione del discorso nella memoria linguistica (Factors in Organizing Speech in Linguistic Memory)

    Science.gov (United States)

    Baroni, Maria Rosa; And Others

    1977-01-01

    An experiment was carried out to study the processes of linguistic memory. Subjects were asked to read aloud brief prose passages and repeat what they had read. The "deviations" from the original passages were analyzed to determine the time of the deviation, during decoding or recall. (Text is in Italian.) (CFM)

  20. Memory, Art and Mourning: the Case of the 'Salón del Nunca Más' of Granada (Antioquia, Colombia

    Directory of Open Access Journals (Sweden)

    Elkin Rubiano Pinilla

    2017-07-01

    Full Text Available This document examines the work produced in the 'Salón del Nunca Más', located in Granada (Antioquia on the subject of collective memory. In this rural town, the 'Salón' has articulated different practices that, along with the construction of memory, have allowed survivors of violence and family members of killed and disappeared individuals to symbolize loss by means of public rituals. On the other hand, the article explores the visual settings that lay down the event, not only the exposure of violent events but the practices of the local community: what happens in the 'Salón', the journalistic covering (written press, the documental photography (Jesús Abad Colorado and the artistic work (Erika Diettes. For this purpose, archival material, a historical interdisciplinary approach, psychoanalysis and image and communication theories, as well as interviews is referenced through this article.

  1. Dynamic contrast-enhanced computed tomography as a potential biomarker in patients with metastatic renal cell carcinoma: preliminary results from the Danish Renal Cancer Group Study-1

    DEFF Research Database (Denmark)

    Mains, Jill Rachel; Donskov, Frede; Pedersen, Erik Morre

    2014-01-01

    OBJECTIVES: The aim of this study was to explore the impact of dynamic contrast-enhanced (DCE) computer tomography (CT) as a biomarker in metastatic renal cell carcinoma (mRCC). MATERIALS AND METHODS: Twelve patients with favorable or intermediate Memorial Sloan Kettering Cancer Center risk group...... blinded to treatment group. The DCE-CT scans were performed at baseline, at weeks 5 and 10, and thereafter every third month. Blood flow (BF; mL/min/100 mL), peak enhancement (Hounsfield units), time to peak (seconds), and blood volume (BV; mL/100 g) were calculated. Parameters for DCE-CT were correlated...

  2. Introducing a music program in the perioperative area.

    Science.gov (United States)

    Cunningham, M F; Monson, B; Bookbinder, M

    1997-10-01

    Music can touch patients deeply and thus transform their anxiety and stress into relaxation and healing. Patients with cancer who undergo surgical procedures are highly stressed. To help alleviate these patients' stress and improve their comfort, perioperative nurses at Memorial Sloan-Kettering Cancer Center (MSKCC), New York, surveyed surgical patients and staff members about introducing a perioperative music program. This article reviews the literature on the use of music in perioperative care settings and describes MSKCC's decision to evaluate and then implement a music program.

  3. Adapted motor activities to stimulate the memory in moderated mentaly retarded boys and girls from “Carlos Marx” Special School of Pinar del Rio

    Directory of Open Access Journals (Sweden)

    Yosbiel García-Castañeda

    2014-08-01

    Full Text Available The present research arises from the necessity of including adapted motor activities to stimulate the memory in moderated mentally retarded boys and girls from “Carlos Marx” Special school of Pinar del Rio in Physical Education lessons, due to the difficulty they have. The activities are addressed to compensate their difficulties from cognitive, psychological, physical, as well as social integration point of view. For the development of the work, firstly, it was carried out a bibliographical revision about the mental retard and about Special Physical Education importance, as means to create compensatory conditions in the psychomotor sphere in children with Special Educational Necessities (SEN, helping them to foster values and attitudes that will be of great utility in the society. Secondly, it was carried out the analysis of the applied methods empiric result as: the observation, interviews, surveys and Mosega Test. In addition, theoretical methods as, historical-logical, analysis - synthesis, inductive-deductive and revision of documents were used. Inside the statistical-mathematical method, the descriptive statistic was applied with the percentage analysis, which allowed designing adapted motor activities for the stimulation of the memory in children with moderate mental retard.

  4. Viaje terminado, viaje inevitable, viaje imposible: la superación literaria del viaje a Europa en Memorial de Aires de Machado de Assis

    Directory of Open Access Journals (Sweden)

    Rubén A. Sánchez-Godoy

    2017-01-01

    Full Text Available Este ensayo propone una aproximación a Memorial de Aires de Machado de Assis (1908. Esta novela recoge las reflexiones que el consejero Aires, un diplomático retirado en Río de Janeiro, hace a propósito de una historia de amor entre dos jóvenes que, después de varias deliberaciones, deciden abandonar Brasil para vivir en Portugal en contra del deseo de sus protectores. El ensayo examina la relevancia de la abolición de la esclavitud en la decisión que toman los jóvenes y cómo ese evento produce una reconsideración tanto de las relaciones entre metrópoli y periferia como de las causas de la tristeza. This essay proposes an approach to Machado de Assis’ last novel, Counselor Aires’ Memorial (1908. In this novel, counselor Aires, a former Brazilian diplomat, narrates the story of a young couple that, after a long decision-making process, decides to move from Brazil to Portugal against the will of their protectors. The essay examines the relevance of the abolition of slavery in Brazil in 1888 for their decision to leave the country, and to what extent abolition promotes a new understanding of the relationship between metropolitan centers and periphery as well as a reflection about the causes of sadness.

  5. Consecuencias cognitivas del programa “memoria en movimiento” en las personas mayores The cognitive consequences of the program “memory in motion” for the elders

    Directory of Open Access Journals (Sweden)

    A. Rey

    2010-09-01

    Full Text Available

     

    El objetivo de este artículo se centra en evaluar los efectos cognoscitivos obtenidos tras la aplicación de un programa de estimulación cognitiva para personas mayores llamado Memoria en Movimiento. Se trata de una investigación cuasi-experimental aplicada a tres grupos con características diferentes: Grupo A: sin deterioro cognitivo, sin problemas de movilidad y sin institucionalizar; Grupo B: sin deterioro cognitivo, con problemas de movilidad e institucionalizados; y Grupo C: con deterioro cognitivo, sin problemas de movilidad e institucionalizados. La muestra de estudio está constituida por 66 personas mayores de 65 años.
    Para evaluar el efecto del programa se utilizó el Mini Examen Cognoscitivo, el Test de Dígitos y una Prueba de memoria motriz diseñada por el equipo de investigación. La recogida de la información se llevó a cabo en dos momentos (pretest y postest del programa. Se ha constatado que existe una mejoría significativa en el grupo A en todas las mediciones de estudio. Por su parte, el grupo B consigue mejoras significativas en el MEC, pero no significativas en el resto de valores, y el grupo C obtiene deterioro no significativo en todos los valores. El programa “Memoria en Movimiento” resulta adecuado para las personas mayores con las características del grupo A. No obstante se hace necesario ampliar la muestra de intervención para poder ratificar los resultados alcanzados en los diferentes grupos de intervención.
    Palabras Clave: Personas mayores, memoria, motricidad, cognición, ejercicio físico.

    The objective of this article is to evaluate the cognitive effects obtained after the application of an intervention program of cognitive stimulation for the elders denominate “Memory in motion ”Quasi-experimental investigation was applied to three groups

  6. Precision Oncology and Genetic Risk Information: Exploring Patients' Preferences and Responses

    Science.gov (United States)

    Dr. Jada Hamilton is an Assistant Member at Memorial Sloan Kettering Cancer Center, as well as an Assistant Attending Psychologist in the Behavioral Sciences Service, Department of Psychiatry and Behavioral Sciences and in the Clinical Genetics Service, Department of Medicine at Memorial Hospital in New York, New York.  She leads a program of research at the intersection of behavioral science, cancer prevention, and genomics, with the goal of translating advances in genetic and genomic medicine into improved cancer care that is of high quality, aligned with patient preferences, and ultimately improves public health.  Dr. Hamilton is also currently leading a study to assess how patients and their families respond to inherited risk information that is revealed as part of tumor sequencing (funded through a Mentored Research Scholar Grant from the American Cancer Society), as well as studies to evaluate alternative models for offering genetic counseling and testing to patients with cancer, and to examine the effects of novel breast cancer genetic risk feedback on patients’ decision-making, psychological, and behavioral outcomes. Prior to joining the faculty of Memorial Sloan Kettering, Dr. Hamilton received a BA in Genetics and Psychology from Ohio Wesleyan University (2004), an MA and PhD in Social and Health Psychology from Stony Brook University (2006, 2009), and an MPH from the Mailman School of Public Health at Columbia University (2010).  She also completed a postdoctoral fellowship as part of the National Cancer Institute’s Cancer Prevention Fellowship Program.

  7. Memoria y retorno del exilio republicano catalán (Memory and Return of the Catalan Republican Exile

    Directory of Open Access Journals (Sweden)

    Roser Pujadas Comas d'Argemir

    2004-01-01

    Full Text Available The end of the Spanish Civil War in 1939 meant that many republicans went into exile fleeing Francoism. In the case of intellectuals and writers from Catalunia, exile constituted the only means of ensuring the continuity of their culture, given the cultural and linguistic repression by the dictatorship. Much later than they had expected, some were able to return but, after so many years, return meant yet another rupture; it meant returning to a country no longer the one so often remembered and yearned for. Such events, as is often the case in turbulent historical periods, generated a need to bear witness to the individual and collective experiences, which in literary terms translated into a considerable volume of testimonial works – which continue to be published – by those who suffered this war and exile. As we shall see, memory becomes a kind of con-suelo – comfort - countering the ruptures with a sense of coherence and continuity. For one who has had to leave their country, the land of their birth becomes part of the past, so that in such cases to make present what is far, to remember, involves not only temporal but also spatial issues. When the exile (if such a thing is possible returns, time inexorably has passed. But what happens with the space re-encountered? In the case of two testimonial texts written by two republicans on their return from exile in Mexico – Al cap de 26 anys (1972 by Avel-lí Artís-Gener and Viatge a l’esperanca (1973, by Artur Bladé Desumvila – we propose to analyse the pattern woven between memory, homeland and return by the experience of exile. We shall see how the return, intended to contrast the idealised country with that in which the exile finds him/herself again, gives rise to a series of reflections about homeland and memory as the foundations of the exile’s identity.

  8. A communication tool for cancer patients with pain: the art therapy technique of the body outline.

    Science.gov (United States)

    Luzzatto, Paola; Sereno, Valerie; Capps, Roy

    2003-06-01

    The multidimensional aspect of pain suggests the use of multimodal interventions. The Memorial Sloan-Kettering Cancer Center has recently utilized the art therapy modality to help patients communicate the painful side of their illness in such a way that they can feel understood and respected. In this paper we describe a simple innovative art therapy intervention that we have developed within the Art Therapy Service in the Psychiatric Department of Memorial Sloan-Kettering Cancer Center. The patients work with a Body Outline as a starting template, together with the art therapist, in sessions lasting approximately 45 minutes. They are encouraged to fill the space inside and outside the Body Outline. They can use colored pastels, markers, or watercolor or cut out images for a collage. Seventy hospitalized adult cancer patients, 60 women and 10 men, used this intervention between January 1999 and May 2000. We have analyzed the variety of responses from the 70 patients, and three main groups have emerged, which have focused on the following issues: (1) visualization of physical pain, (2) communication of emotions, and (3) search for meaning/spirituality. The results suggest that because of its abstract symbolic feature, the Body Outline is a very flexible therapeutic intervention. It must be offered within the relationship with the art therapist, and it may fulfill quite a variety of expressive needs, from the description of physical pain to the elaboration of spiritual longings.

  9. Evolving technologies drive the new roles of Biomedical Engineering.

    Science.gov (United States)

    Frisch, P H; St Germain, J; Lui, W

    2008-01-01

    Rapidly changing technology coupled with the financial impact of organized health care, has required hospital Biomedical Engineering organizations to augment their traditional operational and business models to increase their role in developing enhanced clinical applications utilizing new and evolving technologies. The deployment of these technology based applications has required Biomedical Engineering organizations to re-organize to optimize the manner in which they provide and manage services. Memorial Sloan-Kettering Cancer Center has implemented a strategy to explore evolving technologies integrating them into enhanced clinical applications while optimally utilizing the expertise of the traditional Biomedical Engineering component (Clinical Engineering) to provide expanded support in technology / equipment management, device repair, preventive maintenance and integration with legacy clinical systems. Specifically, Biomedical Engineering is an integral component of the Medical Physics Department which provides comprehensive and integrated support to the Center in advanced physical, technical and engineering technology. This organizational structure emphasizes the integration and collaboration between a spectrum of technical expertise for clinical support and equipment management roles. The high cost of clinical equipment purchases coupled with the increasing cost of service has driven equipment management responsibilities to include significant business and financial aspects to provide a cost effective service model. This case study details the dynamics of these expanded roles, future initiatives and benefits for Biomedical Engineering and Memorial Sloan Kettering Cancer Center.

  10. La Memoria Visual Como Predictor del Aprendizaje de la Lectura Visual Memory as Predictor of Reading Acquisition

    Directory of Open Access Journals (Sweden)

    Mónica Pino

    2005-05-01

    Full Text Available Se presentan los resultados de un estudio longitudinal realizado en alumnos de escuelas municipales de Santiago de Chile, cuyo objetivo fue investigar la relación entre el reconocimiento visual-ortográfico, la percepción y la memoria visual con la lectura inicial. Especialmente se analizó la relación predictiva entre el reconocimiento perceptivo visual de la Figura Compleja de Rey, la memoria visual y el reconocimiento visual-ortográfico con el aprendizaje inicial de la lectura. La muestra estuvo conformada por 105 alumnos de primero básico. Los niños se evaluaron mediante nueve pruebas destinadas al reconocimiento perceptivo visual y visual-ortográfico y una prueba utilizada para evaluar el aprendizaje de la lectura. Los resultados mostraron que la prueba de la Figura Compleja de Rey, que evalúa capacidad de percepción visual, predice significativamente el aprendizaje lector en el nivel inicial.The aim of this article is to present the results of a longitudinal study of a group of public school pupils on their visualperception, visual memory and visual-orthographic recognizing of words and their predictivity on early reading. The sample was comprised of 105 first grade students. The children were assessed using nine tests to measure visual and visual-ortographic perceptual recognition, and a test to measure their reading ability. Results show that Rey's test, which assesses visual perception ability, has a predictive value on initial reading in Spanish speaking Chilean children.

  11. Efectos del desarrollo en la memoria de trabajo y el aprendizaje de categorías en niños Developmet effects on working memory and category learning in children

    Directory of Open Access Journals (Sweden)

    Federico José Sánchez

    2009-12-01

    Full Text Available Se han reportado diferencias relacionadas con la edad en el desempeño de diversas tareas dependientes del lóbulo frontal, incluyendo tareas de memoria de trabajo (Luciana and Nelson, 1998; Luna et al. 2001; Bunge et al., 2002. Se han encontrado también efectos de edad y género sobre la memoria de trabajo en niños (Vuontela et. al, 2003. Además, el aprendizaje de categorías ha sido asociado con la actividad del lóbulo frontal (Dickins, 2000; Schlund 2007. El presente trabajo investigó los efectos de la edad y el género sobre la memoria de trabajo y el aprendizaje de categorías en niños de 8 a 13 años. Se encontraron efectos de edad y género sobre la memoria de trabajo, y en la tarea de aprendizaje de categorías sólo se observaron efectos de la edad. Los resultados sugieren que el desempeño de memoria de trabajo podría estar asociado con la velocidad de procesamiento en el aprendizaje de categorías.Age-related differences have been reported in the performance of several frontal lobe-dependent tasks, including working memory (Luciana and Nelson, 1998; Luna et al. 2001; Bunge et al., 2002. Effects of age and gender on working memory have been found in children (Vuontela et. al, 2003. On the other hand, category learning has also been associated with frontal lobe activity (Dickins, 2000; Schlund 2007. The present study addressed the effects of age and gender on working memory and category learning, in 8-13 year old children. Age and gender effects were found on the working memory task, and age effects only were observed on category learning. The results suggest that working memory performance might be associated with processing speed in the category learning task.

  12. Commentary on: "Ipilimumab versus placebo after radiotherapy in patients with metastatic castration-resistant prostate cancer that had progressed after docetaxel chemotherapy (CA184-043): A multicentre, randomised, double-blind, phase 3 trial." Kwon ED, Drake CG, Scher HI, Fizazi K, Bossi A, van den Eertwegh AJ, Krainer M, Houede N, Santos R, Mahammedi H, Ng S, Maio M, Franke FA, Sundar S, Agarwal N, Bergman AM, Ciuleanu TE, Korbenfeld E, Sengeløv L, Hansen S, Logothetis C, Beer TM, McHenry MB, Gagnier P, Liu D, Gerritsen WR, CA184-043 Investigators. Departments of Urology and Immunology and Mayo Clinic Comprehensive Cancer Center, Mayo Clinic, Rochester, MN, USA, Electronic address: kwon.eugene@mayo.edu; Johns Hopkins Sidney Kimmel Comprehensive Cancer Center and Brady Urological Institute, Baltimore, MD, USA; Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, NY, USA; Institut Gustave Roussy, University of Paris-Sud, Villejuif, France; Institut Gustave Roussy, Villejuif, France; VU University Medical Centre, Amsterdam, Netherlands; Vienna General Hospital, Medical University Vienna, Vienna, Austria; Institut Bergonié, Bordeaux, France; CHU Caremeau, Nimes, France; Centro Médico Austral, Buenos Aires, Argentina; Centre Jean Perrin, Clermont-Ferrand, France; St John of God Hospital, Subiaco, WA, Australia; University Hospital of Siena, Istituto Toscano Tumori, Siena, Italy; Hospital de Caridade de Ijuí, Ijuí, Brazil; Nottingham University Hospital, Nottingham, UK; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA; Netherlands Cancer Institute and Antoni van Leeuwenhoek Hospital, Amsterdam, Netherlands; Institute of Oncology Ion Chiricuta and University of Medicine and Pharmacy Iuliu Hatieganu, Cluj-Napoca, Romania; Hospital Británico de Buenos Aires, Buenos Aires, Argentina; Herlev Hospital, Herlev, Denmark; Odense University Hospital, Odense, Denmark; University of Texas MD Anderson Cancer Center, Houston,

    Science.gov (United States)

    Trump, Donald

    2016-05-01

    Ipilimumab is a fully human monoclonal antibody that binds cytotoxic T-lymphocyte antigen 4 to enhance antitumour immunity. Our aim was to assess the use of ipilimumab after radiotherapy in patients with metastatic castration-resistant prostate cancer that progressed after docetaxel chemotherapy. We did a multicentre, randomised, double-blind, phase 3 trial in which men with at least one bone metastasis from castration-resistant prostate cancer that had progressed after docetaxel treatment were randomly assigned in a 1:1 ratio to receive bone-directed radiotherapy (8Gy in one fraction) followed by either ipilimumab 10mg/kg or placebo every 3 weeks for up to four doses. Non-progressing patients could continue to receive ipilimumab at 10mg/kg or placebo as maintenance therapy every 3 months until disease progression, unacceptable toxic effect, or death. Patients were randomly assigned to either treatment group via a minimisation algorithm, and stratified by Eastern Cooperative Oncology Group performance status, alkaline phosphatase concentration, haemoglobin concentration, and investigator site. Patients and investigators were masked to treatment allocation. The primary endpoint was overall survival, assessed in the intention-to-treat population. This trial is registered with ClinicalTrials.gov, number NCT00861614. From May 26, 2009, to Feb 15, 2012, 799 patients were randomly assigned (399 to ipilimumab and 400 to placebo), all of whom were included in the intention-to-treat analysis. Median overall survival was 11.2 months (95% CI: 9.5-12.7) with ipilimumab and 10.0 months (8.3-11.0) with placebo (hazard ratio [HR] = 0.85, 0.72-1.00; P = 0.053). However, the assessment of the proportional hazards assumption showed that it was violated (P = 0.0031). A piecewise hazard model showed that the HR changed over time: the HR for 0-5 months was 1.46 (95% CI: 1.10-1.95), for 5-12 months was 0.65 (0.50-0.85), and beyond 12 months was 0.60 (0.43-0.86). The most common grade 3-4 adverse events were immune-related, occurring in 101 (26%) patients in the ipilimumab group and 11 (3%) of patients in the placebo group. The most frequent grade 3-4 adverse events included diarrhoea (64 [16%] of 393 patients in the ipilimumab group vs seven [2%] of 396 in the placebo group), fatigue (40 [11%] vs 35 [9%]), anaemia (40 [10%] vs 43 [11%]), and colitis (18 [5%] vs 0). Four (1%) deaths occurred because of toxic effects of the study drug, all in the ipilimumab group. Although there was no significant difference between the ipilimumab group and the placebo group in terms of overall survival in the primary analysis, there were signs of activity with the drug that warrant further investigation. Bristol-Myers Squibb. Copyright © 2016 Elsevier Inc. All rights reserved.

  13. "Memorial de agravios"

    Directory of Open Access Journals (Sweden)

    Boletín Cultural y Bibliográfico Banco de la República

    1959-12-01

    Full Text Available El texto de este célebre documento, conocido con el nombre de Memorial de Agravios, fue redactado por Don Camilo Torres, en su calidad de Asesor del Cabildo de Santafé y se publicó por primera vez en folleto en 1832.

  14. Memory architecture

    NARCIS (Netherlands)

    2012-01-01

    A memory architecture is presented. The memory architecture comprises a first memory and a second memory. The first memory has at least a bank with a first width addressable by a single address. The second memory has a plurality of banks of a second width, said banks being addressable by components

  15. Memorias para armar. Las conmemoraciones del 24 de Marzo en escuelas primarias del conurbano bonaerense

    OpenAIRE

    Gonzalo de Amézola; Claudia D\\u2019Achary

    2009-01-01

    Este artículo se ocupa del problema del tratamiento del pasado reciente en la escuela. Describe las distintas representaciones de la última dictadura militar que se encuentran presentes en los discursos pronunciados en las conmemoraciones realizadas en 2008 para recor - dar el golpe de Estado del 24 de marzo de 1976 en escuelas primarias del partido de Malvinas Argentinas, ubicado en el Conurbano Bonae - rense. Se analiza en esos discursos la presencia de distintas narracio - nes de la memori...

  16. NARRATIVAS DEL YO Y MEMORIAS TRAUMÁTICASNARRATIVAS DO EU E MEMÓRIAS TRAUMÁTICASNARRATIVES OF SELF AND TRAUMATIC MEMORIES

    Directory of Open Access Journals (Sweden)

    Leonor Arfuch

    2012-06-01

    Full Text Available http://dx.doi.org/10.5965/2175180304012012045 Este texto fue presentado como conferencia en la mesa redonda Historia y Narrativas en el Primer Seminario Internacional Historia del Tiempo Presente, impulsado por el Programa de Posgrado en Historia de la UDESC y ANPUH-Santa Catarina, llevado a cabo entre los días 7 y 9 de noviembre de 2011, en Florianópolis/SC. En él, se problematiza el sujeto y su habla, se evidencia el testimonio como narrativa y las diferentes formas en las que la experiencia traumática se traduce en narrativas del yo

  17. Memoria, ideología y crítica: Una fenomenología del mundo ético-político Memory, Ideology and Criticism: A Phenomenology of the Ethical-Political World

    Directory of Open Access Journals (Sweden)

    John Fredy Lenis Castaño

    2009-06-01

    Full Text Available Los conceptos de tradición (ideología y crítica se han polarizado al extremo de estar representados en dos grandes corrientes contemporáneas: la hermenéutica y la teoría crítica, asociadas, a su vez, a las perspectivas conservadora y liberal. Sin embargo, es posible encontrar un campo de intersección entre ambos que hace de su tensión una dialéctica perenne y productiva para el análisis de problemas éticos y políticos como los de la memoria, la evaluación jurídico-moral y la responsabilidad. Este artículo pretende mostrar dicha intersección siguiendo los planteamientos del filósofo francés Paul Ricoeur en un horizonte principalmente fenomenológico y hermenéutico. Para ello se discurrirá a través de siete apartados: alteridad del pasado y reconstrucción de la memoria; tradición, relato y autojustificación ideológica; crítica de la tradición; sobrevuelo de la crítica y anclaje de la tradición; el horizonte utópico de la crítica; narración, memoria y debate; y conclusión: juicios, responsabilidad y reparación.The concepts of tradition (ideology and criticism have been polarized to the point of being represented by two main contemporary currents: hermeneutics and critical theory, which are in turn associated with conservative and liberal views respectively. However, it is possible to find a field of intersection between both of these which makes their tension a perennial and productive dialectic for the analysis of ethical and political problems such as memory, legal and moral assessment, and responsibility. This article aims at showing such an intersection by following the ideas of the French philosopher Paul Ricoeur in a mainly phenomenological and hermeneutic horizon. To achieve this, the article will address seven main sections: altering of the past and the reconstruction of memory; tradition, account, and ideological self-justification; criticism of tradition; the fly-over of criticism and the anchoring of

  18. Los usos del testimonio en los estudios de la memoria. El caso de las violaciones masivas a los derechos humanos en la Argentina (Testimony uses in memory studies. The case of gross violations to human rights in Argentina

    Directory of Open Access Journals (Sweden)

    Julieta Mira

    2017-12-01

    Full Text Available The memory study as an interdisciplinary field in Latin-America has been constructing and consolidating from the nineties of the 20th Century; which gained a driving force from the need to approach the topics regarding the political violence and the massive human rights violations perpetrated by the last military dictatorships. The testimony emerges as a favoured source from which reconstruct the memory of diverse historical-political events, as those linked with gross human rights violations. Taking in advance this challenging opportunity, the research work with testimony requires the comprehension of the sense and the uses, the scope and the limitations of the actors´ (survivors speech as witnesses of violence. This article proposes itself a complex and critical approach to the testimony from a methodological perspective, focused in the case of the last Argentine dictatorship (1976-1983.El campo interdisciplinario de estudio sobre la memoria en Latinoamérica se fue conformando y consolidando desde los años noventa del siglo XX; el cual fue impulsado desde la necesidad de abordar las temáticas relativas a la violencia política y a las violaciones masivas a los derechos humanos en las últimas dictaduras militares. El testimonio emerge como una fuente privilegiada a partir de la cual reconstruir la memoria de diversos sucesos histórico-políticos, como aquellos vinculados a graves violaciones a los derechos humanos. Ante esta desafiante oportunidad, el trabajo de investigación con el testimonio precisa la comprensión del sentido y de los usos, del alcance y de las limitaciones de la palabra de los actores que fueron testigos (supervivientes de violencia. Este artículo se propone desde una mirada metodológica un acercamiento complejo y crítico al testimonio haciendo foco en el caso de la última dictadura militar en la Argentina (1976-1983. DOWNLOAD THIS PAPER FROM SSRN: http://ssrn.com/abstract=3055033

  19. A personal memory of the history of the group of energy and mass transference; Una memoria personal de la historia del grupo de transferencia de energia y masa

    Energy Technology Data Exchange (ETDEWEB)

    Ramos, Eduardo [Centro de Investigacion en Energia (CIE) de la UNAM, Temixco, Morelos (Mexico)

    2010-07-01

    An object that is exposed to sunlight heats up. Based on the everyday experiences, this is a claim that the majority of us would agree. In a more technical note, this object increases its temperature and internal energy. Reflection for a moment, perhaps we would come to the conclusion that the energy captured by the object exposed to solar radiation could be used in a useful fashion. It would require a much longer time of reflection and analysis to imagine the method to convert the heat into useful energy. It is precisely this analysis that has been the objective of the group of energy and mass transference of the Center for Energy Research since its foundation, and probably will remain so while it can be identified as a group of scientific research. In the following pages we will feature briefly, from a personal stand point of view the history of the work, successes and failures of the group since its inception till the present. [Spanish] Un objeto que se expone a la luz solar se calienta. Basados en la experiencia cotidiana, esta es una aseveracion con la que la mayoria de nosotros estaria de acuerdo. Dicho de manera mas tecnica, este objeto aumenta su temperatura y su energia interna. Reflexionando un instante, quiza llegariamos a la conclusion que la energia capturada por el objeto expuesto a la radiacion solar podria ser usada de manera util. Se requeriria un tiempo mucho mas largo de reflexion y analisis para imaginar el metodo para convertir el calor en energia util. Precisamente este analisis ha sido el objetivo del grupo de Transferencia de Energia y Masa del Centro de Investigacion en Energia desde su fundacion, y probablemente lo seguira siendo mientras se le pueda identificar como un grupo de investigacion cientifica. En las paginas siguientes resenaremos brevemente desde un punto de vista personal la historia del trabajo, exitos y fracasos del grupo desde su inicio hasta el presente.

  20. MEMORY MODULATION

    Science.gov (United States)

    Roozendaal, Benno; McGaugh, James L.

    2011-01-01

    Our memories are not all created equally strong: Some experiences are well remembered while others are remembered poorly, if at all. Research on memory modulation investigates the neurobiological processes and systems that contribute to such differences in the strength of our memories. Extensive evidence from both animal and human research indicates that emotionally significant experiences activate hormonal and brain systems that regulate the consolidation of newly acquired memories. These effects are integrated through noradrenergic activation of the basolateral amygdala which regulates memory consolidation via interactions with many other brain regions involved in consolidating memories of recent experiences. Modulatory systems not only influence neurobiological processes underlying the consolidation of new information, but also affect other mnemonic processes, including memory extinction, memory recall and working memory. In contrast to their enhancing effects on consolidation, adrenal stress hormones impair memory retrieval and working memory. Such effects, as with memory consolidation, require noradrenergic activation of the basolateral amygdala and interactions with other brain regions. PMID:22122145

  1. Memory Matters

    Science.gov (United States)

    ... Staying Safe Videos for Educators Search English Español Memory Matters KidsHealth / For Kids / Memory Matters What's in ... of your complex and multitalented brain. What Is Memory? When an event happens, when you learn something, ...

  2. Electroplating targets for production of unique PET radionuclides

    International Nuclear Information System (INIS)

    Bui, V.; Sheh, Y.; Finn, R.

    1994-01-01

    The past decade has witnessed the applications of Positron Emission Tomography (PET) evolving from a purely research endeavour to a procedure which has specific clinical applications in the areas of cardiology, neurology and oncology. The growth of PET has been facilitated by developments in medical instrumentation and radiopharmaceutical chemistry efforts. Included in this latter effort has been the low energy accelerator production and processing of unique PET radionuclides appropriate for the radiolabeling of biomolecules i.e. monoclonal antibodies and pepetides. The development and application of electroplated targets of antimony and copper for the production of iodine-124 and gallium-66 respectively, utilizing the Memorial Sloan-Kettering Cancer Center cyclotron are examples of target design and development applicable to many medical accelerators

  3. Radiation induced sarcomas of bone following therapeutic radiation

    International Nuclear Information System (INIS)

    Kim, J.H.; Chu, F.C.H.; Woodward, H.Q.; Huvos, A.

    1983-01-01

    Because of new therapeutic trends of multi-modality and the importance of late effects, we have updated our series of radiation induced bone sarcomas seen at Memorial Sloan-Kettering Cancer Center over the past four decades. A total of 37 cases of bone sarcoma arising from normal bone in the irradiated field was analyzed. The median for latent period from irradiation to diagnosis of bone sarcoma was 11 years with a minimum latent period of four years. The median radiation dose for the bone sarcoma was 6000 rad in 6 weeks with a minimum total radiation dose of 3000 rad in 3 weeks. We have found nine patients who developed bone sarcomas in the radiation field after successful treatment of Hodgkin's disease. Criteria for radiation induced bone sarcomas and the magnitude of the risk of bone sarcomas are briefly discussed

  4. The Syed temporary interstitial iridium gynaecological implant: an inverse planning system

    International Nuclear Information System (INIS)

    Fung, Albert Y.C.

    2002-01-01

    Patients with advanced gynaecological cancer are often treated with a temporary interstitial implant using the Syed template and Ir-192 ribbons at the Memorial Sloan-Kettering Cancer Center. Urgency in planning is great. We created a computerized inverse planning system for the Syed temporary gynaecological implant, which optimized the ribbon strengths a few seconds after catheter digitization. Inverse planning was achieved with simulated annealing. We discovered that hand-drawn target volumes had drawbacks; hence instead of producing a grid of points based on target volume, the optimization points were generated directly from the catheter positions without requiring an explicit target volume. Since all seeds in the same ribbon had the same strength, the minimum doses were located at both ends of the implant. Optimization points generated at both ends ensured coverage of the whole implant. Inverse planning took only a few seconds, and generated plans that provide a good starting point for manual improvement. (author)

  5. Translational Bioinformatics and Clinical Research (Biomedical) Informatics.

    Science.gov (United States)

    Sirintrapun, S Joseph; Zehir, Ahmet; Syed, Aijazuddin; Gao, JianJiong; Schultz, Nikolaus; Cheng, Donavan T

    2015-06-01

    Translational bioinformatics and clinical research (biomedical) informatics are the primary domains related to informatics activities that support translational research. Translational bioinformatics focuses on computational techniques in genetics, molecular biology, and systems biology. Clinical research (biomedical) informatics involves the use of informatics in discovery and management of new knowledge relating to health and disease. This article details 3 projects that are hybrid applications of translational bioinformatics and clinical research (biomedical) informatics: The Cancer Genome Atlas, the cBioPortal for Cancer Genomics, and the Memorial Sloan Kettering Cancer Center clinical variants and results database, all designed to facilitate insights into cancer biology and clinical/therapeutic correlations. Copyright © 2015 Elsevier Inc. All rights reserved.

  6. Focal low-dose rate brachytherapy for the treatment of prostate cancer

    Directory of Open Access Journals (Sweden)

    Tong WY

    2013-09-01

    Full Text Available William Y Tong, Gilad Cohen, Yoshiya Yamada Memorial Sloan-Kettering Cancer Center, Department of Radiation Oncology, New York, NY, USA Abstract: Whole-gland low-dose rate (LDR brachytherapy has been a well-established modality of treating low-risk prostate cancer. Treatment in a focal manner has the advantages of reduced toxicity to surrounding organs. Focal treatment using LDR brachytherapy has been relatively unexplored, but it may offer advantages over other modalities that have established experiences with a focal approach. This is particularly true as prostate cancer is being detected at an earlier and more localized stage with the advent of better detection methods and newer imaging modalities. Keywords: prostate cancer, focal, low dose rate, brachytherapy

  7. The state of the art in therapeutic nuclear medicine

    International Nuclear Information System (INIS)

    Allen, B.J.

    2001-01-01

    Radionuclide therapy can be curative or palliative in intent, and local or systemic in administration. Current therapy relies of beta emitting radioisotopes and selective carriers for the treatment of advanced tumours. The next generation of therapeutics may be alpha emitting radionuclides for subclinical, micrometastatic disease. Targeted Alpha therapy (TAT) offers the potential to inhibit the growth of micrometastases by selectively killing isolated and preangiogenic clusters of cancer cells. The practicality and efficacy of TAT has been tested by in vitro and in vivo studies many cancers. The first phase 1 clinical trial of TAT for leukaemia with Bi-213 has concluded at the Memorial Sloan Kettering Cancer Center, a phase 1 and 2 trial of intra-lesional TAT is ongoing at Duke University with At-211 labeled Mab against cystic glioma, and a phase 1 and 2 clinical trial for intra-lesional TAT with Bi-213 of subcutaneous secondary melanoma is underway at St George Hospital

  8. Management of cutaneous T cell lymphoma: new and emerging targets and treatment options

    Directory of Open Access Journals (Sweden)

    Li JY

    2012-03-01

    Full Text Available Janet Y Li1, Steven Horwitz2, Alison Moskowitz2, Patricia L Myskowski3, Melissa Pulitzer4, Christiane Querfeld31College of Physicians and Surgeons, Columbia University, 2Department of Medicine, Lymphoma Service, 3Department of Medicine, Dermatology Service, 4Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USAAbstract: Cutaneous T cell lymphomas (CTCL clinically and biologically represent a heterogeneous group of non-Hodgkin lymphomas, with mycosis fungoides and Sézary syndrome being the most common subtypes. Over the last decade, new immunological and molecular pathways have been identified that not only influence CTCL phenotype and growth, but also provide targets for therapies and prognostication. This review will focus on recent advances in the development of therapeutic agents, including bortezomib, the histone deacetylase inhibitors (vorinostat and romidepsin, and pralatrexate in CTCL.Keywords: novel targets, histone deacetylase inhibitors, pralatrexate, bortezomib, cutaneous T cell lymphoma

  9. Risk factors and classifications of hilar cholangiocarcinoma.

    Science.gov (United States)

    Suarez-Munoz, Miguel Angel; Fernandez-Aguilar, Jose Luis; Sanchez-Perez, Belinda; Perez-Daga, Jose Antonio; Garcia-Albiach, Beatriz; Pulido-Roa, Ysabel; Marin-Camero, Naiara; Santoyo-Santoyo, Julio

    2013-07-15

    Cholangiocarcinoma is the second most common primary malignant tumor of the liver. Perihilar cholangiocarcinoma or Klatskin tumor represents more than 50% of all biliary tract cholangiocarcinomas. A wide range of risk factors have been identified among patients with Perihilar cholangiocarcinoma including advanced age, male gender, primary sclerosing cholangitis, choledochal cysts, cholelithiasis, cholecystitis, parasitic infection (Opisthorchis viverrini and Clonorchis sinensis), inflammatory bowel disease, alcoholic cirrhosis, nonalcoholic cirrhosis, chronic pancreatitis and metabolic syndrome. Various classifications have been used to describe the pathologic and radiologic appearance of cholangiocarcinoma. The three systems most commonly used to evaluate Perihilar cholangiocarcinoma are the Bismuth-Corlette (BC) system, the Memorial Sloan-Kettering Cancer Center and the TNM classification. The BC classification provides preoperative assessment of local spread. The Memorial Sloan-Kettering cancer center proposes a staging system according to three factors related to local tumor extent: the location and extent of bile duct involvement, the presence or absence of portal venous invasion, and the presence or absence of hepatic lobar atrophy. The TNM classification, besides the usual descriptors, tumor, node and metastases, provides additional information concerning the possibility for the residual tumor (R) and the histological grade (G). Recently, in 2011, a new consensus classification for the Perihilar cholangiocarcinoma had been published. The consensus was organised by the European Hepato-Pancreato-Biliary Association which identified the need for a new staging system for this type of tumors. The classification includes information concerning biliary or vascular (portal or arterial) involvement, lymph node status or metastases, but also other essential aspects related to the surgical risk, such as remnant hepatic volume or the possibility of underlying disease.

  10. Efectos del ejercicio físico sobre la memoria episódica en ancianas chilenas sanas (Effects of Physical Exercise on the Episodic Memory in Healthy Elderly Chileans

    Directory of Open Access Journals (Sweden)

    Norman López

    2015-06-01

    Full Text Available Resumen: El objetivo de esta investigación fue analizar el efecto de un programa de actividad física regular sobre la memoria episódica verbal y visuoespacial en ancianas chilenas mentalmente sanas. Participaron 74 ancianas sin deterioro cognitivo, divididas en un grupo de intervención, integrado por 34 de ellas, que realizaron actividad física por seis meses; y un grupo control integrado por 40 sedentarias. Se utilizó el Test de Aprendizaje Auditivo Verbal de Rey (TAAVR y el Test de la Figura Compleja de Rey (TFCR para la evaluación de la memoria episódica. Asimismo, se realizaron análisis inter e intragrupales con t student y d de Cohen para medir el tamaño de efecto de las pruebas t. Los resultados evidenciaron diferencias estadísticamente significativas en el postest entre el grupo de intervención (GI y grupo control (GC, observándose mejor rendimiento en las pruebas de memoria episódica verbal y visual del GI con un tamaño de efecto alto. Se concluye que la actividad física regular aumenta la capacidad de procesamiento, retención y evocación de la información verbal y visual episódica en mujeres ancianas sanas. Abstract: Our objective was to analyze the effect of a regular physical activity program on the verbal and visuospatial episodic memory on mentally healthy elderly Chileans. Participated 74 elderly women without cognitive impairment – divided into an intervention group = 34 elderly women, who carried out physical activity for six months; and a control group = 40 sedentary women. We used the Rey Auditory Verbal Learning Test (RAVLT, and the Rey Complex Figure Test (RCFT for the evaluation of the episodic memory. Analysis were performed inter- and intra-group with t student and d of Cohen to measure the effect size of t-tests. The results showed statistically significant differences in the post-test between the Intervention Group (IG and Control Group (CG; noticing better yields in the verbal and visual episodic

  11. The effect of motor activity on improved memory andemotional well-being in elderly women. (Influencia de la actividad motora en la mejora de la memoria y del estado de ánimo emocional de mujeres mayores.

    Directory of Open Access Journals (Sweden)

    Alberto Fernández Lucas

    2008-10-01

    Full Text Available AbstractThis study researches the effect of a wide range of different types of intervention (cognitive versus cognitive + motor versus non-intervention on the memory and mental state of elderly women complaining of memory loss and leading a sedentary life. Subjects (N=102, 80% women, age M/SD = 76/5 years were distributed randomly into the three treatment groups. The cognitive training consisted of attention exercises, language, association of ideas and problem solving while the motor training consisted of proprioceptive and dynamic exercises related to the body schema, balance and movement coordination. The duration of the treatment period was 8 months. The Rivermead Behavioural Memory Test (RBMT and the Yesavage´s Geriatric Scale of Depression (GDS were applied before and after the treatment period. Results showed improvements associated with both interventions but deterioration in the control group. However, only the cognitive-motor group showed relevant improvement according to the above-mentioned tests. Results suggest that combined cognitive-motor intervention is more promising than the simply cognitive in improving memory function and the state of well-being in women who complained of subjective memory loss, and that both techniques are effective when compared with non-intervention. ResumenEste estudio investiga el efecto de diversos tipos de intervención (cognitiva versus cognitiva + motora versus no intervención en la memoria y el estado de ánimo emocional en mujeres mayores con quejas de memoria y con una vida pasiva. Los sujetos (N=102, 80% mujeres, edad M/SD = 76/5 años se distribuyeron de forma aleatoria en los tres grupos de tratamiento. El entrenamiento cognitivo consistió en ejercicios de atención, lenguaje, asociación de ideas y resolución de problemas. El entrenamiento motor consistió en ejercicios propioceptivos y dinámicos relacionados con el esquema corporal, el equilibrio y la coordinación de movimientos. La

  12. Peces del Noroeste del Ecuador

    OpenAIRE

    Barriga, Ramiro

    1994-01-01

    La ictiofauna del occidente del Ecuador es poco conocida. Los peces del noroccidente son diferentes a los del suroccidente del Ecuador. 34 familias y 82 especies fueron colectadas que equivale al 11 % de las especies de peces continentales registradas en el Ecuador. Icteogeográficamente se sabe que la costa ecuatoriana posee dos provincias: la del Pacifico Norte y la del Guayas, se determinó que el límite de las dos provincias es el río Santiago ya que las especies del mencionado río so...

  13. Cognitive memory.

    Science.gov (United States)

    Widrow, Bernard; Aragon, Juan Carlos

    2013-05-01

    Regarding the workings of the human mind, memory and pattern recognition seem to be intertwined. You generally do not have one without the other. Taking inspiration from life experience, a new form of computer memory has been devised. Certain conjectures about human memory are keys to the central idea. The design of a practical and useful "cognitive" memory system is contemplated, a memory system that may also serve as a model for many aspects of human memory. The new memory does not function like a computer memory where specific data is stored in specific numbered registers and retrieval is done by reading the contents of the specified memory register, or done by matching key words as with a document search. Incoming sensory data would be stored at the next available empty memory location, and indeed could be stored redundantly at several empty locations. The stored sensory data would neither have key words nor would it be located in known or specified memory locations. Sensory inputs concerning a single object or subject are stored together as patterns in a single "file folder" or "memory folder". When the contents of the folder are retrieved, sights, sounds, tactile feel, smell, etc., are obtained all at the same time. Retrieval would be initiated by a query or a prompt signal from a current set of sensory inputs or patterns. A search through the memory would be made to locate stored data that correlates with or relates to the prompt input. The search would be done by a retrieval system whose first stage makes use of autoassociative artificial neural networks and whose second stage relies on exhaustive search. Applications of cognitive memory systems have been made to visual aircraft identification, aircraft navigation, and human facial recognition. Concerning human memory, reasons are given why it is unlikely that long-term memory is stored in the synapses of the brain's neural networks. Reasons are given suggesting that long-term memory is stored in DNA or RNA

  14. Memory Modulation

    NARCIS (Netherlands)

    Roozendaal, Benno; McGaugh, James L.

    2011-01-01

    Our memories are not all created equally strong: Some experiences are well remembered while others are remembered poorly, if at all. Research on memory modulation investigates the neurobiological processes and systems that contribute to such differences in the strength of our memories. Extensive

  15. Memory Dysfunction

    Science.gov (United States)

    Matthews, Brandy R.

    2015-01-01

    Purpose of Review: This article highlights the dissociable human memory systems of episodic, semantic, and procedural memory in the context of neurologic illnesses known to adversely affect specific neuroanatomic structures relevant to each memory system. Recent Findings: Advances in functional neuroimaging and refinement of neuropsychological and bedside assessment tools continue to support a model of multiple memory systems that are distinct yet complementary and to support the potential for one system to be engaged as a compensatory strategy when a counterpart system fails. Summary: Episodic memory, the ability to recall personal episodes, is the subtype of memory most often perceived as dysfunctional by patients and informants. Medial temporal lobe structures, especially the hippocampal formation and associated cortical and subcortical structures, are most often associated with episodic memory loss. Episodic memory dysfunction may present acutely, as in concussion; transiently, as in transient global amnesia (TGA); subacutely, as in thiamine deficiency; or chronically, as in Alzheimer disease. Semantic memory refers to acquired knowledge about the world. Anterior and inferior temporal lobe structures are most often associated with semantic memory loss. The semantic variant of primary progressive aphasia (svPPA) is the paradigmatic disorder resulting in predominant semantic memory dysfunction. Working memory, associated with frontal lobe function, is the active maintenance of information in the mind that can be potentially manipulated to complete goal-directed tasks. Procedural memory, the ability to learn skills that become automatic, involves the basal ganglia, cerebellum, and supplementary motor cortex. Parkinson disease and related disorders result in procedural memory deficits. Most memory concerns warrant bedside cognitive or neuropsychological evaluation and neuroimaging to assess for specific neuropathologies and guide treatment. PMID:26039844

  16. Declarative memory.

    Science.gov (United States)

    Riedel, Wim J; Blokland, Arjan

    2015-01-01

    Declarative Memory consists of memory for events (episodic memory) and facts (semantic memory). Methods to test declarative memory are key in investigating effects of potential cognition-enhancing substances--medicinal drugs or nutrients. A number of cognitive performance tests assessing declarative episodic memory tapping verbal learning, logical memory, pattern recognition memory, and paired associates learning are described. These tests have been used as outcome variables in 34 studies in humans that have been described in the literature in the past 10 years. Also, the use of episodic tests in animal research is discussed also in relation to the drug effects in these tasks. The results show that nutritional supplementation of polyunsaturated fatty acids has been investigated most abundantly and, in a number of cases, but not all, show indications of positive effects on declarative memory, more so in elderly than in young subjects. Studies investigating effects of registered anti-Alzheimer drugs, cholinesterase inhibitors in mild cognitive impairment, show positive and negative effects on declarative memory. Studies mainly carried out in healthy volunteers investigating the effects of acute dopamine stimulation indicate enhanced memory consolidation as manifested specifically by better delayed recall, especially at time points long after learning and more so when drug is administered after learning and if word lists are longer. The animal studies reveal a different picture with respect to the effects of different drugs on memory performance. This suggests that at least for episodic memory tasks, the translational value is rather poor. For the human studies, detailed parameters of the compositions of word lists for declarative memory tests are discussed and it is concluded that tailored adaptations of tests to fit the hypothesis under study, rather than "off-the-shelf" use of existing tests, are recommended.

  17. Quantum memory Quantum memory

    Science.gov (United States)

    Le Gouët, Jean-Louis; Moiseev, Sergey

    2012-06-01

    Interaction of quantum radiation with multi-particle ensembles has sparked off intense research efforts during the past decade. Emblematic of this field is the quantum memory scheme, where a quantum state of light is mapped onto an ensemble of atoms and then recovered in its original shape. While opening new access to the basics of light-atom interaction, quantum memory also appears as a key element for information processing applications, such as linear optics quantum computation and long-distance quantum communication via quantum repeaters. Not surprisingly, it is far from trivial to practically recover a stored quantum state of light and, although impressive progress has already been accomplished, researchers are still struggling to reach this ambitious objective. This special issue provides an account of the state-of-the-art in a fast-moving research area that makes physicists, engineers and chemists work together at the forefront of their discipline, involving quantum fields and atoms in different media, magnetic resonance techniques and material science. Various strategies have been considered to store and retrieve quantum light. The explored designs belong to three main—while still overlapping—classes. In architectures derived from photon echo, information is mapped over the spectral components of inhomogeneously broadened absorption bands, such as those encountered in rare earth ion doped crystals and atomic gases in external gradient magnetic field. Protocols based on electromagnetic induced transparency also rely on resonant excitation and are ideally suited to the homogeneous absorption lines offered by laser cooled atomic clouds or ion Coulomb crystals. Finally off-resonance approaches are illustrated by Faraday and Raman processes. Coupling with an optical cavity may enhance the storage process, even for negligibly small atom number. Multiple scattering is also proposed as a way to enlarge the quantum interaction distance of light with matter. The

  18. «No one has seen these images, but they exist»: The memory of exile in contemporary Argentina «Nadie habrá visto esas imágenes, pero existen»: a propósito de las memorias del exilio en la Argentina actual

    Directory of Open Access Journals (Sweden)

    Silvina JENSEN

    2010-10-01

    Full Text Available This paper examines how Argentines remember the experience of exile from the military dictatorship, with particular emphasis on the public discussion of the theme of exile in Argentine in recent years. Through a contextualization of the memory of exile in the struggle to keep alive the memory State terrorism, the article aims to show how since the mid-1990s we are witnessing a repositioning of the experience of exile in the memory of the years of repression. According to the author, this new social interest on exile –expressed in the emergence of a number of publications on exile, the development of cultural, legal and legislative spaces are giving rise to a public airing of the theme of exile– is less the result of the emergence of unpublished material, but more the result of a new vision which is emerging from the academic community and from society in general on the self-proclaimed «Process of National Reorganization». Este trabajo analiza los modos en que los argentinos recuerdan el exilio de la dictadura militar, enfatizando la peculiar inscripción pública del tema del exilio en la Argentina en los últimos años. A partir de la contextualización de la memoria del destierro en las luchas por el recuerdo del terrorismo de Estado pretendo mostrar cómo desde mediados de la década de 1990 se está produciendo un lento reposicionamiento del exilio en la memoria de la represión. A juicio de la autora, este nuevo interés social sobre el exilio –expresado en la publicación de literatura sobre el exilio, la configuración de escenarios culturales, judiciales y legislativos que convocan a problematizar al destierro, etc.– no es tanto el resultado de la aparición de información inédita, indicios desconocidos o flamantes huellas, sino de la nueva mirada que sobre los tiempos del autoproclamado «Proceso de Reorganización Nacional» se está articulando tanto desde la comunidad académica como de la sociedad en su conjunto.

  19. Memory design

    DEFF Research Database (Denmark)

    Tanderup, Sisse

    by cultural forms, often specifically by the concept of memory in philosophy, sociology and psychology, while Danish design traditionally has been focusing on form and function with frequent references to the forms of nature. Alessi's motivation for investigating the concept of memory is that it adds......Mind and Matter - Nordik 2009 Conference for Art Historians Design Matters Contributed Memory design BACKGROUND My research concerns the use of memory categories in the designs by the companies Alessi and Georg Jensen. When Alessi's designers create their products, they are usually inspired...... a cultural dimension to the design objects, enabling the objects to make an identity-forming impact. Whether or not the concept of memory plays a significant role in Danish design has not yet been elucidated fully. TERMINOLOGY The concept of "memory design" refers to the idea that design carries...

  20. Disputed Memory

    DEFF Research Database (Denmark)

    , individual and political discourse and electronic social media. Analyzing memory disputes in various local, national and transnational contexts, the chapters demonstrate the political power and social impact of painful and disputed memories. The book brings new insights into current memory disputes...... in Central, Eastern and Southeastern Europe. It contributes to the understanding of processes of memory transmission and negotiation across borders and cultures in Europe, emphasizing the interconnectedness of memory with emotions, mediation and politics....... century in the region. Written by an international group of scholars from a diversity of disciplines, the chapters approach memory disputes in methodologically innovative ways, studying representations and negotiations of disputed pasts in different media, including monuments, museum exhibitions...

  1. Main Memory

    OpenAIRE

    Boncz, Peter; Liu, Lei; Özsu, M.

    2008-01-01

    htmlabstractPrimary storage, presently known as main memory, is the largest memory directly accessible to the CPU in the prevalent Von Neumann model and stores both data and instructions (program code). The CPU continuously reads instructions stored there and executes them. It is also called Random Access Memory (RAM), to indicate that load/store instructions can access data at any location at the same cost, is usually implemented using DRAM chips, which are connected to the CPU and other per...

  2. Collaging Memories

    Science.gov (United States)

    Wallach, Michele

    2011-01-01

    Even middle school students can have memories of their childhoods, of an earlier time. The art of Romare Bearden and the writings of Paul Auster can be used to introduce ideas about time and memory to students and inspire works of their own. Bearden is an exceptional role model for young artists, not only because of his astounding art, but also…

  3. Memory Magic.

    Science.gov (United States)

    Hartman, Thomas G.; Nowak, Norman

    This paper outlines several "tricks" that aid students in improving their memories. The distinctions between operational and figural thought processes are noted. Operational memory is described as something that allows adults to make generalizations about numbers and the rules by which they may be combined, thus leading to easier memorization.…

  4. Memory loss

    Science.gov (United States)

    ... barbiturates or ( hypnotics ) ECT (electroconvulsive therapy) (most often short-term memory loss) Epilepsy that is not well controlled Illness that ... appointment. Medical history questions may include: Type of memory loss, such as short-term or long-term Time pattern, such as how ...

  5. Episodic Memories

    Science.gov (United States)

    Conway, Martin A.

    2009-01-01

    An account of episodic memories is developed that focuses on the types of knowledge they represent, their properties, and the functions they might serve. It is proposed that episodic memories consist of "episodic elements," summary records of experience often in the form of visual images, associated to a "conceptual frame" that provides a…

  6. Flavor Memory

    NARCIS (Netherlands)

    Mojet, Jos; Köster, Ep

    2016-01-01

    Odor, taste, texture, temperature, and pain all contribute to the perception and memory of food flavor. Flavor memory is also strongly linked to the situational aspects of previous encounters with the flavor, but does not depend on the precise recollection of its sensory features as in vision and

  7. Main Memory

    NARCIS (Netherlands)

    P.A. Boncz (Peter); L. Liu (Lei); M. Tamer Özsu

    2008-01-01

    htmlabstractPrimary storage, presently known as main memory, is the largest memory directly accessible to the CPU in the prevalent Von Neumann model and stores both data and instructions (program code). The CPU continuously reads instructions stored there and executes them. It is also called Random

  8. Accessing memory

    Science.gov (United States)

    Yoon, Doe Hyun; Muralimanohar, Naveen; Chang, Jichuan; Ranganthan, Parthasarathy

    2017-09-26

    A disclosed example method involves performing simultaneous data accesses on at least first and second independently selectable logical sub-ranks to access first data via a wide internal data bus in a memory device. The memory device includes a translation buffer chip, memory chips in independently selectable logical sub-ranks, a narrow external data bus to connect the translation buffer chip to a memory controller, and the wide internal data bus between the translation buffer chip and the memory chips. A data access is performed on only the first independently selectable logical sub-rank to access second data via the wide internal data bus. The example method also involves locating a first portion of the first data, a second portion of the first data, and the second data on the narrow external data bus during separate data transfers.

  9. Memory Reconsolidation.

    Science.gov (United States)

    Haubrich, Josue; Nader, Karim

    2018-01-01

    Scientific advances in the last decades uncovered that memory is not a stable, fixed entity. Apparently stable memories may become transiently labile and susceptible to modifications when retrieved due to the process of reconsolidation. Here, we review the initial evidence and the logic on which reconsolidation theory is based, the wide range of conditions in which it has been reported and recent findings further revealing the fascinating nature of this process. Special focus is given to conceptual issues of when and why reconsolidation happen and its possible outcomes. Last, we discuss the potential clinical implications of memory modifications by reconsolidation.

  10. Olfactory Memory

    Science.gov (United States)

    Eichenbaum, Howard; Robitsek, R. Jonathan

    2009-01-01

    Odor-recognition memory in rodents may provide a valuable model of cognitive aging. In a recent study we used signal detection analyses to distinguish odor recognition based on recollection versus that based on familiarity. Aged rats were selectively impaired in recollection, with relative sparing of familiarity, and the deficits in recollection were correlated with spatial memory impairments. These results complement electro-physiological findings indicating age-associated deficits in the ability of hippocampal neurons to differentiate contextual information, and this information-processing impairment may underlie the common age-associated decline in olfactory and spatial memory. PMID:19686208

  11. Architecture and memory

    Directory of Open Access Journals (Sweden)

    Eneida de Almeida

    2015-12-01

    Full Text Available This paper investigates the links between architecture design and restoration, considering the blurry frontier that distinguishes this actions. The study holds in two contemporary architects performance: Lina Bo Bardi (1914-1992 and Aldo Rossi (1931-1997. The analyses of the concrete production, presented here by a work of each architecture – Sesc Pompeia and the Teatro Del Mondo – is based on the ability of reflection on the role of the memory in architecture: not only the memory in the buildings and urban fabrics materiality, but also the memory as an active instrument inside the mental processes adopted by the projects authors. Resorting to architects writings as well as authors who analyses this interventions, they seek to reconstitute the design development path, recognizing the strategy that reinterprets past experiences in order to overcome the traditional contraposition between “old” and “new”, tutorship and innovation.

  12. Multiferroic Memories

    Directory of Open Access Journals (Sweden)

    Amritendu Roy

    2012-01-01

    Full Text Available Multiferroism implies simultaneous presence of more than one ferroic characteristics such as coexistence of ferroelectric and magnetic ordering. This phenomenon has led to the development of various kinds of materials and conceptions of many novel applications such as development of a memory device utilizing the multifunctionality of the multiferroic materials leading to a multistate memory device with electrical writing and nondestructive magnetic reading operations. Though, interdependence of electrical- and magnetic-order parameters makes it difficult to accomplish the above and thus rendering the device to only two switchable states, recent research has shown that such problems can be circumvented by novel device designs such as formation of tunnel junction or by use of exchange bias. In this paper, we review the operational aspects of multiferroic memories as well as the materials used for these applications along with the designs that hold promise for the future memory devices.

  13. Color Memory

    OpenAIRE

    Pate, Monica; Raclariu, Ana-Maria; Strominger, Andrew

    2017-01-01

    A transient color flux across null infinity in classical Yang-Mills theory is considered. It is shown that a pair of test `quarks' initially in a color singlet generically acquire net color as a result of the flux. A nonlinear formula is derived for the relative color rotation of the quarks. For weak color flux the formula linearizes to the Fourier transform of the soft gluon theorem. This color memory effect is the Yang-Mills analog of the gravitational memory effect.

  14. Autobiografía y memoria en el diario de viajes del VI Conde de Fernán Núñez = Autobiography and Memory in the Travel Diary of the VI Count of Fernán Núñez

    Directory of Open Access Journals (Sweden)

    Carolina Blutrach

    2016-12-01

    Full Text Available ResumenEl viaje fue una constante en la vida de don Carlos José Gutiérrez de los Ríos, VI conde de Fernán Núñez (1742-1795. A través de ellos pudo cumplir con su servicio al rey y con sus responsabilidades como cabeza del linaje. Asimismo pudo completar su formación y satisfacer anhelos más personales. De todos sus viajes, los realizados dentro y fuera de España, guardó memoria escrita en un diario de viajes, un documento que, en formato manuscrito, se conservó en su archivo familiar. En un periodo cronológico en el que el viaje y su relato adquirieron especial protagonismo, este trabajo analiza el papel que el viaje jugó en la vida y memoria del VI conde de Fernán Núñez y su impronta dentro del linaje.AbstractTravelling had a constant presence in the life of don Carlos José Gutiérrez de los Ríos, VI Count of Fernán Núñez (1742-1795. Through them he could fulfil his service to the king and his responsibilities as head of the lineage. He could also complete his training and meet more personal yearnings. Of all his travels, the ones he made in and out of Spain, he kept a record in his Travel Diary, which was preserved as a manuscript in the family archive. In a period in which travelling and its written memory gained special prominence, this paper analyses the role it played in the life and memory of the VI Count of Fernán Núñez and its mark within the lineage.

  15. Potencial del Agua del suelo

    Directory of Open Access Journals (Sweden)

    Bustamante Heliodoro

    1986-12-01

    Full Text Available La energía potencial del agua presenta diferencias de un punto del suelo a otro; esas diferencias son las que originan el movimiento del agua de acuerdo a la tendencia universal de la materia en el sentido de moverse de donde la energía potencial es mayor a donde dicha energía es menor. En el suelo el agua en consecuencia se mueve hacia donde su energía decrece hasta lograr su estado de equilibrio. Se desprende entonces que la cantidad de energía potencial absoluta contenida en el agua, no es importante por sí misma, sino por su relación con la energía en diferentes lugares dentro del suelo. El concepto Potencial de agua del suelo es un criterio para esta energía.

  16. Consideraciones económicas-sociales "El memorial de agravios"

    Directory of Open Access Journals (Sweden)

    Eduardo Umaña Luna

    1959-12-01

    Full Text Available A los 150 años de la producción de "El Memorial de Agravios", las tesis de don Camilo Torres mantienen una extraordinaria vigencia, ya que en el presente momento hispanoamericano, que incide con la crisis de secular es sistemas del itinerario universal, los planteamientos sociales, políticos y económicos del famoso documento del prócer payanés, corresponden a mucho de nuestra realidad.

  17. Holographic memories

    DEFF Research Database (Denmark)

    Ramanujam, P.S.; Berg, R.H.; Hvilsted, Søren

    1999-01-01

    A Two-dimensional holographic memory for archival storage is described. Assuming a coherent transfer function, an A4 page can be stored at high resolution in an area of 1 mm(2). Recently developed side-chain liquid crystalline azobenzene polyesters are found to be suitable media for holographic...

  18. Sharing Memories

    DEFF Research Database (Denmark)

    Rodil, Kasper; Nielsen, Emil Byskov; Nielsen, Jonathan Bernstorff

    2018-01-01

    in which it was to be contextualized and through a close partnership between aphasics and their caretakers. The underlying design methodology for the MemoryBook is Participatory Design manifested through the collaboration and creations by two aphasic residents and one member of the support staff. The idea...

  19. Memory consolidation

    NARCIS (Netherlands)

    Takashima, A.; Bakker, I.; Schmid, H.-J.

    2016-01-01

    In order to make use of novel experiences and knowledge to guide our future behavior, we must keep large amounts of information accessible for retrieval. The memory system that stores this information needs to be flexible in order to rapidly incorporate incoming information, but also requires that

  20. Skilled Memory.

    Science.gov (United States)

    1980-11-06

    Woodworth, R. S. Experimental Psychology. New York: Henry Holt and Co., 1938. Yates, F. A. The art of memory. London: Rutledge and Kegan Paul, 1966. 50...Group 1 Psychologist (TAEG) ON! Branch Office Dept. of the Navy 1030 East Green Street Orlando, FL 32813 Pasadena, CA 91101 1 Dr. Richard Sorensen I

  1. del alcoholismo

    Directory of Open Access Journals (Sweden)

    Rodrigo Arias Duque

    2005-01-01

    Full Text Available Desde el punto de vista farmacológico, es importante comprender qué es el alcohol y cómo actúa en el organismo. No existe una causa simple, sino una interacción complicada de factores neuroquímicos, fisiológicos, psicológicos y sociales que originan y desarrollan esta grave enfermedad fármaco-dependiente. La acción psicofisiológica y farmacodinámica del alcohol es fundamentalmente depresiva, por la reducción de la transmisión sináptica en el sistema nervioso humano. Es un hecho conocido que el consumo excesivo de alcohol causa una disfunción aguda y crónica del cerebro, produciendo trastornos en el sistema nervioso central, presentando alteraciones en la memoria y en las funciones intelectuales como cálculo, comprensión y aprendizaje. A nivel hepático tiene lugar, en su mayoría, el metabolismo del alcohol, produciéndose un hígado graso alcohólico, aumentando el tamaño, terminando en necrosis e inflamación grave del hígado; esto se llama hepatitis alcohólica, y si se sigue consumiendo alcohol se desarrollará la cirrosis. El alcohol también ha estado relacionado con alteraciones del miocardio; se ha constatado en animales de experimentación sanos que tanto la velocidad de contracción del músculo cardiaco y su máxima tensión disminuyen en presencia del alcohol, como consecuencia, la fuerza de cada contracción y el aumento de presión en el ventrículo izquierdo son menores, perdiendo eficacia el corazón como bomba.

  2. Specification and development of the sharing memory data management module for a nuclear processes simulator; Especificacion y desarrollo del modulo de administracion de datos de memoria compartida para un simulador de procesos nucleares

    Energy Technology Data Exchange (ETDEWEB)

    Telesforo R, D. [UNAM, DEPFI, Campus Morelos, Jiutepec, Morelos (Mexico)]. e-mail: cchavez2@cableonline.com.mx

    2003-07-01

    Actually it is developed in the Engineering Faculty of UNAM a simulator of nuclear processes with research and teaching purposes. It consists of diverse modules, included the one that is described in the present work that is the shared memory module. It uses the IPC mechanisms of the UNIX System V operative system, and it was codified with C language. To model the diverse components of the simulator the RELAP code is used. The function of the module is to generate locations of shared memory for to deposit in these the necessary variables for the interaction among the diverse ones processes of the simulator. In its it will be able read and to write the information that generate the running of the simulation program, besides being able to interact with the internal variables of the code in execution time. The graphic unfolding (mimic, pictorials, tendency graphics, virtual instrumentation, etc.) they also obtain information of the shared memory. In turn, actions of the user in interactive unfolding, they modify the segments of shared memory, and the information is sent to the RELAP code to modify the simulation course. The program has two beginning modes: automatic and manual. In automatic mode taking an enter file of RELAP (indta) and it joins in shared memory, the control variables that in this appear. In manual mode the user joins, he reads and he writes the wanted control variables, whenever they exist in the enter file (indta). This is a dynamic mode of interacting with the simulator in a direct way and of even altering the values as when its don't exist in the board elements associated to the variables. (Author)

  3. Concrete Memories

    DEFF Research Database (Denmark)

    Wiegand, Frauke Katharina

    2015-01-01

    This article traces the presence of Atlantikwall bunkers in amateur holiday snapshots and discusses the ambiguous role of the bunker site in visual cultural memory. Departing from my family’s private photo collection from twenty years of vacationing at the Danish West coast, the different mundane...... and poetic appropriations and inscriptions of the bunker site are depicted. Ranging between overlooked side presences and an overwhelming visibility, the concrete remains of fascist war architecture are involved in and motivate different sensuous experiences and mnemonic appropriations. The article meets...... the bunkers’ changing visuality and the cultural topography they both actively transform and are being transformed by through juxtaposing different acts and objects of memory over time and in different visual articulations....

  4. Treadwell Memorial

    OpenAIRE

    Downey, Frances K

    2015-01-01

    This is a memorial to gold mining in Southeast Alaska. The structure takes visitors from the Treadwell trail onto the edge of a popular local beach, reclaiming a forgotten place that was once the largest gold mine in the world. A tangible tribute to this obscure period of history, this building kindles a connection between artifacts and the community. It is a liminal space, connecting ocean and mountain, past and present, civilization and wilderness. An investigation of the Treadwell Gold...

  5. Culturas del Mundo

    DEFF Research Database (Denmark)

    Benwell, Ann Fenger; Costa, Alberto; Waehle, Espen

    2006-01-01

    ’Culturas del mundo. Colecciones del Museo Nacional de Dinamarca’ with Ann Fenger Benwell in Culturas del Mundo. Colecciones del Museo Nacional de Dinamarca, ed. Silvia Sauquet, Fundación "la Caixa", Barcelona 2006, pp. 31-39......’Culturas del mundo. Colecciones del Museo Nacional de Dinamarca’ with Ann Fenger Benwell in Culturas del Mundo. Colecciones del Museo Nacional de Dinamarca, ed. Silvia Sauquet, Fundación "la Caixa", Barcelona 2006, pp. 31-39...

  6. OPEN CHAIR MEMORY, LIFE STORIES, AND THE ROLE OF LISTENING IN THE SUBJECTIVE TRANSFORMATION OF VICTIMS / SURVIVORS OF THE COLOMBIAN ARMED CONFLICT. MEMORIA, HISTORIAS DE VIDA Y PAPEL DE LA ESCUCHA EN LA TRANSFORMACIÓN SUBJETIVA DE VÍCTIMAS / SOBREVIVIENTES DEL CONFLICTO ARMADO COLOMBIANO.

    Directory of Open Access Journals (Sweden)

    Juan David Villa Gómez.

    2014-06-01

    Full Text Available Abstract: This research article aims to demonstrate, from a qualitative point of view, the importance of the processes of intervention and research in both collective memory and historical memory, based on the development of life stories, for the construction of complex looks and the reflection on psychosocial, socio-symbolic and socio-structural aspects, both of the participating subjects and the contexts in which these subjects live and move, particularly in their relationship with the armed conflict, their consequences on subjectivity, but also the resistance, the forms of the coping perspective, and the processes of transformation experienced. In this text, it is made evident the manner how the armed conflict in Colombia can be looked logically, from the real-life stories of 58 participants and the life stories of 4 other participants. Besides, of showing the importance of the testimony and its relationship with the listening in the reconstruction processes of the memory and the psychosocial action with victims of the Colombian armed conflict, which leads to the conclusion, that the real-life stories and life stories herein referred, have in common, is resistance as the main driving force (including the coping perspective and resilience, that is to say, a reading, an interpretation based on the capabilities, in the force to assume, in the solutions provided, in the daily struggle, and in the senses found, even in the midst of horror. Resumen: El presente artículo de investigación pretende, desde una mirada cualitativa, evidenciar la importancia de los procesos de intervención/investigación en memoria colectiva y memoria histórica, fundamentados en la elaboración de historias de vida, para la construcción de miradas complejas y la reflexión sobre aspectos psicosociales, socio-simbólicos y socio-estructurales, tanto de los sujetos participantes, como también de los contextos en los cuales habitan y se mueven estos sujetos, en

  7. Memórias e representações sociais do Sistema Único de Saúde por seus usuários Memorias y representaciones sociales del sistema único de salud por sus usuarios Memories and social representations about the unified health system acording to the users

    Directory of Open Access Journals (Sweden)

    Caren Camargo do Espírito Santo

    2012-03-01

    Full Text Available Esse estudo tem como objetivo analisar o conteúdo das memórias e das representações do Sistema Único de Saúde (SUS desenvolvidas por seus usuários. Possui abordagem qualitativa, baseado na Teoria das Representações e Memória Sociais. Foram selecionadas 15 entrevistas de usuários da rede hospitalar e 15 da rede básica, e realizada análise de conteúdo temática. Originaram-se três categorias, porém este estudo refere-se apenas a uma categoria, denominada Representações Sociais e Memórias do SUS. Os sujeitos reconhecem o SUS como um sistema de saúde para todos. Sobressai o bom atendimento, assim como relatam as facilidades e dificuldades dos serviços de saúde. Relatam também a utilização dos serviços de saúde no setor privado e utilização do sistema de referência como um elemento facilitador. Conclui-se que a representação sobre o SUS é a universalidade e que este estudo permitiu entender como o usuário do SUS vivencia seu processo de implementação.Este estudio tiene como objetivo analizar el contenido de las memorias y representaciones del Sistema Único de Salud (SUS desarrolladas por sus usuarios. Es cualitativo, basado en la Teoría de las Representaciones y Memoria Sociales. Fueron seleccionadas 15 entrevistas de usuarios de la red de hospitales y 15 de la red básica, y se realizaron análisis de contenido temático. Originaron tres categorías, pero este estudio sólo se refiere a una, denominada Representaciones Sociales y Memorias del SUS. Los entrevistados reconocen a SUS como un sistema de salud para todos. Destacan el atendimiento adecuado, los puntos fuertes y las dificultades de los servicios de salud. Informan la utilización del sector privado de salud y del sistema de referencia como un facilitador. Concluye que la representación de SUS es la universalidad y que este estudio sirvió para comprender como el usuario vive su proceso de implementación.This study aims to analyze the content of the

  8. Efeito da anestesia geral na cognição e na memória do idoso Efecto de la anestesia general en la cognición y memoria del paciente de edad avanzada Effects of general anesthesia in elderly patients’ memory and cognition

    Directory of Open Access Journals (Sweden)

    Régis Borges Aquino

    2004-10-01

    7 horas.JUSTIFICATIVA Y OBJETIVOS: La anestesia general y la función mental han sido objetivos de estudios y consideraciones, especialmente por el sentimiento de que ella, particularmente en paciente de edad avanzada, podría inducir alteraciones en la cognición y en la memoria. El objetivo de esa pesquisa fue evaluar el efecto de la anestesia general en la cognición y en la memoria del paciente de edad avanzada correlacionándola al sexo, a la edad y al tiempo de anestesia. MÉTODO: Estudio de coorte controlado realizado en pacientes categorizados en dos grupos de observación: a- anestésico; b- clínicos (controle. Las variables del resultado consideradas fueron los escores del teste MiniMental, del teste de Fluencia Verbal y del test de Recuerdo Numérico. Anestesia general con halotano, isoflurano, sevoflurano, tiopental, propofol, etomidato, fentanil alfentanil, succinilcolina atracúrio, pancuronio. Intra-operatorio con PaCO2 entre 30 y 45 mmHg y saturación de hemoglobina superior a 90% y tolerancia de PA con disminución hasta 20% del valor basal. Fueron excluidos pacientes que presentaron algún evento adverso en el intra y pos-operatorio. Datos categóricos analizados por el test del Qui-cuadrado. La comparación inicial entre los grupos en el momento basal (pre-anestésico fue realizada por la t de Student para muestras independientes. Para evaluación del efecto del proceso anestésico a lo largo del tiempo, fue utilizado el análisis de variancia (ANOVA para medidas repetidas. RESULTADOS: En el teste del MiniMental los grupos presentaron comportamiento semejante siendo notado aumento de escores a lo largo del tiempo. En el test de Fluencia Verbal, en ambos los grupos los escores se mantuvieron prácticamente inalterados. En el test de Recuerdo Numérico el comportamiento de los grupos fue muy semejante a lo largo del seguimiento siendo que los escores aumentaran en ambos los grupos. CONCLUSIONES: No fue detectado declinio de cognición o de memoria

  9. Efecto del tipo de prueba de evaluación en la memoria y valoración de marcas publicitarias (Effect of the type of memory test on the evaluation of brands

    Directory of Open Access Journals (Sweden)

    Beatriz Martín-Luengo

    2012-12-01

    Full Text Available Memory tests are frequently used to measure the effectiveness of an advertisement. However, as different tests provide different kinds of information it is important to know which type of test is the most appropriate. The main objective of this investigation was to study the effect of different memory tests on the number of brands recalled and the level of interest generated by them. A group of participants wrote down all the brands of any kind of product that they remembered having seen advertised (free recall test and rated their interest in each brand. Subsequently, the participants were given a list of 27 categories and wrote down the brands they associated with the categories (cued recall test and also rated their level of interest. The results showed that although the participants generated more brand names with the cued recall test, the brand names mentioned in the free recall test generated greater interest. These results highlight the importance of choosing the correct memory test to measure the effect of publicity.

  10. Analysis of Daily Memory in students of the University Program for Older People in Almería Análisis de la Memoria Cotidiana en alumnos del Programa Universitario para Mayores en Almería

    Directory of Open Access Journals (Sweden)

    José J. Gázquez

    2010-05-01

    Full Text Available Universities for older people are currently one of the most popular programs for active ageing Spain. Older people's participation in such programs has repercussions, not only in the improvement of their integration and social activity, but also in that learning at these ages produces benefits in physical and mental health. Thus, the goal of our investigation is to analyze these benefits in daily memory (spatial, linguistic, sequential, and of things from attending the University for Older People. For this purpose, the sample is made up of two groups, one from the University for Older People, who have been attending it for more than five years (N= 264, and a group of people over 50 years who do not attend the University for Older People (N= 453. In a comparison of both groups, the results show that the students from the University for Older People obtain significantly lower global scores in daily memory, linguistic memory, sequential memory and memory of things. Las Universidades de Mayores son uno de los programas actuales de envejecimiento activo con mayor auge en España. La participación en estos tiene una repercusión no sólo en la mejora de la integración y actividad social, sino que los aprendizajes en estas edades reportan beneficios en la salud física y mental. Así, el objetivo de nuestra investigación es analizar estos beneficios respecto a la memoria cotidiana (espacial, lingu?ística, secuencial y de cosas de la asistencia a la Universidad de Mayores. Para ello la muestra está compuesta de dos grupos uno perteneciente a la Universidad de Mayores, que llevan en esta más de cinco años (N= 264, y otro de mayores de 50 años que no pertenecen a la Universidad de Mayores (N= 453. En una comparativa de ambos grupos, los resultados nos muestran, que los alumnos de la Universidad de Mayores obtienen puntuaciones significativamente menores en la puntuación global de memoria cotidiana, en la memoria lingu?ística, secuencial y de

  11. Transactional Memory

    CERN Document Server

    Harris, Tim; Rajwar, Ravi

    2010-01-01

    The advent of multicore processors has renewed interest in the idea of incorporating transactions into the programming model used to write parallel programs.This approach, known as transactional memory, offers an alternative, and hopefully better, way to coordinate concurrent threads. The ACI(atomicity, consistency, isolation) properties of transactions provide a foundation to ensure that concurrent reads and writes of shared data do not produce inconsistent or incorrect results. At a higher level, a computation wrapped in a transaction executes atomically - either it completes successfullyand

  12. Intentionally fabricated autobiographical memories

    OpenAIRE

    Justice, LV; Morrison, CM; Conway, MA

    2017-01-01

    Participants generated both autobiographical memories (AMs) that they believed to be true and intentionally fabricated autobiographical memories (IFAMs). Memories were constructed while a concurrent memory load (random 8-digit sequence) was held in mind or while there was no concurrent load. Amount and accuracy of recall of the concurrent memory load was reliably poorer following generation of IFAMs than following generation of AMs. There was no reliable effect of load on memory generation ti...

  13. STRUKTUR DAN PROSES MEMORI

    Directory of Open Access Journals (Sweden)

    Magda Bhinnety

    2015-09-01

    Full Text Available This paper describes structures and processes of human memory system according to the modal model. Sensory memory is described as the first system to store information from outside world. Short‐term memory, or now called working memory, represents a system characterized by limited ability in storing as well as retrieving information. Long‐term memory on the hand stores information larger in amount and longer than short‐term memory

  14. STRUKTUR DAN PROSES MEMORI

    OpenAIRE

    Bhinnety, Magda

    2015-01-01

    This paper describes structures and processes of human memory system according to the modal model. Sensory memory is described as the first system to store information from outside world. Short‐term memory, or now called working memory, represents a system characterized by limited ability in storing as well as retrieving information. Long‐term memory on the hand stores information larger in amount and longer than short‐term memory

  15. La perversa máquina del olvido: cómics y memoria de la posguerra en la España de los 90 = The perverse machine of oblivion: comics and postwar memory in 90’s Spain

    Directory of Open Access Journals (Sweden)

    Pedro Pérez del Solar

    2015-06-01

    Maus (Art Spiegelman se sabe que los cómics pueden vehicular reflexiones sobre la memoria de formas muy distintas a las de la literatura o el cine; El Artefacto Perverso, lejos de cualquier fórmula, muestra que esa exploración continúa. This paper analyses the Spanish graphic novel El Artefacto Perverso (The Perverse Machine, 1996 by Felipe Hernández Cava and Federico del Barrio. This study shows how, by employing comics resources at their best, this work constructs a complex and compelling reflection on memory, especially that of the losers of the Spanish civil war (1936–39. The subject of memory is at the core of El Artefacto Perverso. Characters speak about it; plots concur in it. The main one, the level of ‘reality’, is set in post-war Madrid. There, those who lost the civil war try to forget their past, struggling for surviving in a silence that the guerrilla strives to break. Around this one, other stories emerge and dialogue with each other. One narrates the memories of a Spanish republican refugee in France. Another shows an agonizing republican agent that speaks about the erasure of all the losers of the war from the pages of history. Finally, there is the comic book written by the main character, where an all-Spanish-hero, Pedro Guzmán, saves the world from a perverse machine that causes oblivion. The contact with the main plot, charges this ingenuous story line with critical significance. Style also speaks about memory: Fading memories of refugee camp and feverish narrations have, each one, a correlated graphic representation. Pedro Guzmán’s adventures bring to mind the post-war by employing conventions of Spanish comics of the forties. All of this has implications about contemporary Spain. There, El Artefacto Perverso confronts the official discourse of the democracy regime, where war and post war periods have been consciously neglected. Since Maus, we are sure that comics can vehicle reflections on memory in

  16. Electroconvulsive therapy and memory.

    Science.gov (United States)

    Harper, R G; Wiens, A N

    1975-10-01

    Recent research on the effects of electroconvulsive therapy (ECT) on memory is critically reviewed. Despite some inconsistent findings, unilateral nondominant ECT appears to affect verbal memory less than bilateral ECT. Adequate research on multiple monitored ECT is lacking. With few exceptions, the research methodologies for assessing memory have been inadequate. Many studies have confounded learning with retention, and only very recently has long term memory been adequately studied. Standardized assessment procedures for short term and long term memory are needed, in addition to more sophisticated assessment of memory processes, the duration of memory loss, and qualitative aspects of memories.

  17. Pärt, Arvo. Cantus in memory of Benjamin Britten / Andrew Achenbach

    Index Scriptorium Estoniae

    Achenbach, Andrew

    1995-01-01

    Uuest heliplaadist "Pärt, Arvo. Cantus in memory of Benjamin Britten. BBC Northern Symphony Orchestra / Norman del Mar; BBC Symphony Orchestra / Gennady Rozhdestvensky". BBC Radio Classics CD BBCRD 9129 (71 minutes)

  18. Detailed sensory memory, sloppy working memory

    NARCIS (Netherlands)

    Sligte, I.G.; Vandenbroucke, A.R.E.; Scholte, H.S.; Lamme, V.A.F.

    2010-01-01

    Visual short-term memory (VSTM) enables us to actively maintain information in mind for a brief period of time after stimulus disappearance. According to recent studies, VSTM consists of three stages - iconic memory, fragile VSTM, and visual working memory - with increasingly stricter capacity

  19. Episodic memory, semantic memory, and amnesia.

    Science.gov (United States)

    Squire, L R; Zola, S M

    1998-01-01

    Episodic memory and semantic memory are two types of declarative memory. There have been two principal views about how this distinction might be reflected in the organization of memory functions in the brain. One view, that episodic memory and semantic memory are both dependent on the integrity of medial temporal lobe and midline diencephalic structures, predicts that amnesic patients with medial temporal lobe/diencephalic damage should be proportionately impaired in both episodic and semantic memory. An alternative view is that the capacity for semantic memory is spared, or partially spared, in amnesia relative to episodic memory ability. This article reviews two kinds of relevant data: 1) case studies where amnesia has occurred early in childhood, before much of an individual's semantic knowledge has been acquired, and 2) experimental studies with amnesic patients of fact and event learning, remembering and knowing, and remote memory. The data provide no compelling support for the view that episodic and semantic memory are affected differently in medial temporal lobe/diencephalic amnesia. However, episodic and semantic memory may be dissociable in those amnesic patients who additionally have severe frontal lobe damage.

  20. NARRATIVAS DEL YO Y MEMORIAS TRAUMÁTICASNARRATIVAS DO EU E MEMÓRIAS TRAUMÁTICASNARRATIVES OF SELF AND TRAUMATIC MEMORIES

    OpenAIRE

    Leonor Arfuch

    2012-01-01

    http://dx.doi.org/10.5965/2175180304012012045 Este texto fue presentado como conferencia en la mesa redonda Historia y Narrativas en el Primer Seminario Internacional Historia del Tiempo Presente, impulsado por el Programa de Posgrado en Historia de la UDESC y ANPUH-Santa Catarina, llevado a cabo entre los días 7 y 9 de noviembre de 2011, en Florianópolis/SC. En él, se problematiza el sujeto y su habla, se evidencia el testimonio como narrativa y las diferentes formas en las que la experi...

  1. Optical memory

    Science.gov (United States)

    Mao, Samuel S; Zhang, Yanfeng

    2013-07-02

    Optical memory comprising: a semiconductor wire, a first electrode, a second electrode, a light source, a means for producing a first voltage at the first electrode, a means for producing a second voltage at the second electrode, and a means for determining the presence of an electrical voltage across the first electrode and the second electrode exceeding a predefined voltage. The first voltage, preferably less than 0 volts, different from said second voltage. The semiconductor wire is optically transparent and has a bandgap less than the energy produced by the light source. The light source is optically connected to the semiconductor wire. The first electrode and the second electrode are electrically insulated from each other and said semiconductor wire.

  2. Approccio dal basso, servizi alla persona e memorie interculturali

    Directory of Open Access Journals (Sweden)

    Orazio Maria Valastro

    2003-06-01

    Full Text Available Valorizzare le memorie dei migranti risponde ad una precisa esigenza di riconoscimento, nella storia collettiva e nello spazio politico nazionale, della memoria interculturale di intere collettività ... Queste condizioni implicano l'esigenza del riconoscimento della memoria dei migranti traducendosi in uno stimolo per lo sviluppo di nuove politiche sociali e culturali e di nuovi interventi focalizzati su questo stesso riconoscimento che interessa direttamente anche gli operatori sociali e culturali delle amministrazioni pubbliche e del terzo settore.

  3. Memory, microprocessor, and ASIC

    CERN Document Server

    Chen, Wai-Kai

    2003-01-01

    System Timing. ROM/PROM/EPROM. SRAM. Embedded Memory. Flash Memories. Dynamic Random Access Memory. Low-Power Memory Circuits. Timing and Signal Integrity Analysis. Microprocessor Design Verification. Microprocessor Layout Method. Architecture. ASIC Design. Logic Synthesis for Field Programmable Gate Array (EPGA) Technology. Testability Concepts and DFT. ATPG and BIST. CAD Tools for BIST/DFT and Delay Faults.

  4. Infant Visual Recognition Memory

    Science.gov (United States)

    Rose, Susan A.; Feldman, Judith F.; Jankowski, Jeffery J.

    2004-01-01

    Visual recognition memory is a robust form of memory that is evident from early infancy, shows pronounced developmental change, and is influenced by many of the same factors that affect adult memory; it is surprisingly resistant to decay and interference. Infant visual recognition memory shows (a) modest reliability, (b) good discriminant…

  5. LA IMPLICANCIA DE LA MEMORIA Y LA IDENTIDAD EN LA CONSTITUCIÓN DEL PATRIMONIO. ALGUNAS REFLEXIONES / Some thoughts on the implications of memory and identity in the constitution of the patrimony.

    Directory of Open Access Journals (Sweden)

    María Belén Colasurdo

    2010-12-01

    Full Text Available En el presente trabajo se reflexiona acerca de la relación entre los conceptos de Memoria – Identidad – Patrimonio desde un enfoque antropológico. A partir de la ambigüedad intrínseca que caracteriza a los mismos, se considera el papel preponderante que juegan los mecanismos de memoria/olvido-identidades individuales/identidad colectiva en la elección de lo que será considerado patrimonio dentro de una comunidad. El concepto de patrimonio no ha sido el mismo a lo largo de la historia y su cambiante significado ha transitado, desde la idea inicial de tesoro ilustrado, hasta la de recurso turístico, pasando por su valoración como producto cultural y mecanismo de construcción de identidad. El museo es una de las instituciones que se encargan de determinar y perpetuar qué se considera patrimonio y qué no. El mismo puede representar bien o mal el pasado, puede distorsionarlo a partir de sus selecciones y clasificaciones, puede restringir el pasado a través de su código de representación histórica, la forma en que cuenta su historia, la forma en que son presentados los artefactos. Estos últimos son reunidos y presentados para generar un sentido particular para el visitante que los observa.Palabras clave: memoria; patrimonio; identidad; museo; antropología. AbstractThis paper is about the relation between the concepts of Memory – Identity – Patrimony from an anthropological focus. Since the intrinsic ambiguity of those concepts, it´s considered the preponderant role play by the mechanism of memory/oblivion-individual identities/collective identity in the choose of what it will be considered patrimony inside a community. The concept of patrimony have not been the same along the history and its changing meaning have evolve since the idea of an illustrated treasure to the idea of a touristic resource, and rating it as a cultural product and a mechanism of identity construction. The museum is one of the institution in charge of

  6. Memoria del mal

    Directory of Open Access Journals (Sweden)

    Semprún, Jorge

    2011-06-01

    Full Text Available In May 2003 the twelfth edition of the «Aranguren Conferences» was held. Jorge Semprún gave three keynote speeches titled «Kant and the Maquis’ rucksack», «The radical evil and the Buchenwald latrines» and «Literature and memory of the evil: from Sartre to Paul Ricoeur», all of them grouped under the generic denomination Memory of Evil. The thread running through the three speeches was Semprún’s experience as a political deportee at Buchenwald concentration camp, so close to the Weimar camp of Schiller and Goethe. There, he could experience the radical evil, but also the brotherhood through the antifascist resistance groups who coordinated the various clandestine political groups at the camp. This experience helped him review some of the philosophical readings he had done as a philosphy student at the Sorbonne, as well as those readings he took an interest in following the end of the war. In this way, Semprún went over various authors (Immanuel Kant, André Malraux, Edmund Husserl, Jacques Maritain, Martin Heidegger, Karl Marx, Hannah Arendt, Jean Paul Sartre, Paul Ricoeur or Primo Levi arguing their relationship with the issue of Evil.

    En mayo de 2003 se celebró la duodécima edición de las «Conferencias Aranguren». Jorge Semprún dictó tres conferencias magistrales tituladas «Kant y la mochila del maquis», «El mal radical y las letrinas de Buchenwald» y «Literatura y memoria del mal: de Sartre a Paul Ricoeur», agrupadas todas ellas bajo el título genérico de Memoria del mal. El hilo conductor de las tres intervenciones fue la experiencia de Semprún como deportado político en el campo de concentración de Buchenwald, tan cercano al Weimar de Schiller y Goethe. Allí pudo experimentar el mal radical, pero también la fraternidad, a través de los grupos de resistencia antifascista que coordinaban en el campo los distintos grupos políticos clandestinos. Esta experiencia le sirvió para repasar las lecturas

  7. Nanoscale memory devices

    International Nuclear Information System (INIS)

    Chung, Andy; Deen, Jamal; Lee, Jeong-Soo; Meyyappan, M

    2010-01-01

    This article reviews the current status and future prospects for the use of nanomaterials and devices in memory technology. First, the status and continuing scaling trends of the flash memory are discussed. Then, a detailed discussion on technologies trying to replace flash in the near-term is provided. This includes phase change random access memory, Fe random access memory and magnetic random access memory. The long-term nanotechnology prospects for memory devices include carbon-nanotube-based memory, molecular electronics and memristors based on resistive materials such as TiO 2 . (topical review)

  8. Il dono del racconto

    DEFF Research Database (Denmark)

    Polito, Paola

    1998-01-01

    L'articolo indaga a vari livelli strutturali del romanzo "Il coraggio del pettirosso" (rete metaforica, dialogismo diegetico, dialogismo come fenomeno di voce, strategie discorsive messe in atto dalla voce narrante, stile colloquiale) la complessa realizzazione testuale del genere narrativo...

  9. Visual memory needs categories

    OpenAIRE

    Olsson, Henrik; Poom, Leo

    2005-01-01

    Capacity limitations in the way humans store and process information in working memory have been extensively studied, and several memory systems have been distinguished. In line with previous capacity estimates for verbal memory and memory for spatial information, recent studies suggest that it is possible to retain up to four objects in visual working memory. The objects used have typically been categorically different colors and shapes. Because knowledge about categories is stored in long-t...

  10. Non-volatile memories

    CERN Document Server

    Lacaze, Pierre-Camille

    2014-01-01

    Written for scientists, researchers, and engineers, Non-volatile Memories describes the recent research and implementations in relation to the design of a new generation of non-volatile electronic memories. The objective is to replace existing memories (DRAM, SRAM, EEPROM, Flash, etc.) with a universal memory model likely to reach better performances than the current types of memory: extremely high commutation speeds, high implantation densities and retention time of information of about ten years.

  11. Memory: sins and virtues

    OpenAIRE

    Schacter, Daniel L.

    2013-01-01

    Memory plays an important role in everyday life but does not provide an exact and unchanging record of experience: research has documented that memory is a constructive process that is subject to a variety of errors and distortions. Yet these memory “sins” also reflect the operation of adaptive aspects of memory. Memory can thus be characterized as an adaptive constructive process, which plays a functional role in cognition but produces distortions, errors, or illusions as a consequence of d...

  12. Salam Memorial

    CERN Document Server

    Rubbia, Carlo

    1997-01-01

    by T.W.B. KIBBLE / Blackett Laboratory, Imperial College, London. Recollections of Abdus Salam at Imperial College I shall give a personal account of Professor Salam's life and work from the perspective of a colleague at Imperial College, concentrating particularly but not exclusively on the period leading up to the discovery of the electro-weak theory. If necessary I could perhaps give more detail, but only once I have given more thought to what ground I shall cover. by Sheldon Lee GLASHOW / Harvard University, Cambridge, MA, USA. Memories of Abdus Salam. My interactions with Abdus Salam, weak as they have been, extended over five decades. I regret that we never once collaborated in print or by correspondence. I visited Abdus only twice in London and twice again in Trieste, and met him at the occasional conference or summer school. Our face-to-face encounters could be counted on one's fingers and toes, but we became the best of friends. Others will discuss Abdus as an inspiring teacher, as a great scientist,...

  13. del cambio

    Directory of Open Access Journals (Sweden)

    Alejandro Canales

    2006-01-01

    Full Text Available El artículo analiza las propuestas y los compromisos en materia de cobertura y de financiamiento en el periodo 2000-2006. En particular, revisa las modificaciones y los ajustes de los tres principales documentos en los que se expresaron las iniciativas: el de la Asociación Nacional de Universidades e Instituciones de Educación Superior, el del equipo de la transición y el programa sectorial. Los resultados muestran que las cifras de atención a la demanda educativa e inversión quedaron lejos de las metas autoimpuestas por el gobierno federal y que será necesario realizar mayores esfuerzos para atender tales desafíos.

  14. Organizational memory: from expectations memory to procedural memory

    NARCIS (Netherlands)

    Ebbers, J.J.; Wijnberg, N.M.

    2009-01-01

    Organizational memory is not just the stock of knowledge about how to do things, but also of expectations of organizational members vis-à-vis each other and the organization as a whole. The central argument of this paper is that this second type of organizational memory -organizational expectations

  15. Visual Memories Bypass Normalization.

    Science.gov (United States)

    Bloem, Ilona M; Watanabe, Yurika L; Kibbe, Melissa M; Ling, Sam

    2018-05-01

    How distinct are visual memory representations from visual perception? Although evidence suggests that briefly remembered stimuli are represented within early visual cortices, the degree to which these memory traces resemble true visual representations remains something of a mystery. Here, we tested whether both visual memory and perception succumb to a seemingly ubiquitous neural computation: normalization. Observers were asked to remember the contrast of visual stimuli, which were pitted against each other to promote normalization either in perception or in visual memory. Our results revealed robust normalization between visual representations in perception, yet no signature of normalization occurring between working memory stores-neither between representations in memory nor between memory representations and visual inputs. These results provide unique insight into the nature of visual memory representations, illustrating that visual memory representations follow a different set of computational rules, bypassing normalization, a canonical visual computation.

  16. Stochastic memory: getting memory out of noise

    Science.gov (United States)

    Stotland, Alexander; di Ventra, Massimiliano

    2011-03-01

    Memory circuit elements, namely memristors, memcapacitors and meminductors, can store information without the need of a power source. These systems are generally defined in terms of deterministic equations of motion for the state variables that are responsible for memory. However, in real systems noise sources can never be eliminated completely. One would then expect noise to be detrimental for memory. Here, we show that under specific conditions on the noise intensity memory can actually be enhanced. We illustrate this phenomenon using a physical model of a memristor in which the addition of white noise into the state variable equation improves the memory and helps the operation of the system. We discuss under which conditions this effect can be realized experimentally, discuss its implications on existing memory systems discussed in the literature, and also analyze the effects of colored noise. Work supported in part by NSF.

  17. Detailed Sensory Memory, Sloppy Working Memory

    OpenAIRE

    Sligte, Ilja G.; Vandenbroucke, Annelinde R. E.; Scholte, H. Steven; Lamme, Victor A. F.

    2010-01-01

    Visual short-term memory (VSTM) enables us to actively maintain information in mind for a brief period of time after stimulus disappearance. According to recent studies, VSTM consists of three stages - iconic memory, fragile VSTM, and visual working memory - with increasingly stricter capacity limits and progressively longer lifetimes. Still, the resolution (or amount of visual detail) of each VSTM stage has remained unexplored and we test this in the present study. We presented people with a...

  18. Detailed sensory memory, sloppy working memory.

    Science.gov (United States)

    Sligte, Ilja G; Vandenbroucke, Annelinde R E; Scholte, H Steven; Lamme, Victor A F

    2010-01-01

    Visual short-term memory (VSTM) enables us to actively maintain information in mind for a brief period of time after stimulus disappearance. According to recent studies, VSTM consists of three stages - iconic memory, fragile VSTM, and visual working memory - with increasingly stricter capacity limits and progressively longer lifetimes. Still, the resolution (or amount of visual detail) of each VSTM stage has remained unexplored and we test this in the present study. We presented people with a change detection task that measures the capacity of all three forms of VSTM, and we added an identification display after each change trial that required people to identify the "pre-change" object. Accurate change detection plus pre-change identification requires subjects to have a high-resolution representation of the "pre-change" object, whereas change detection or identification only can be based on the hunch that something has changed, without exactly knowing what was presented before. We observed that people maintained 6.1 objects in iconic memory, 4.6 objects in fragile VSTM, and 2.1 objects in visual working memory. Moreover, when people detected the change, they could also identify the pre-change object on 88% of the iconic memory trials, on 71% of the fragile VSTM trials and merely on 53% of the visual working memory trials. This suggests that people maintain many high-resolution representations in iconic memory and fragile VSTM, but only one high-resolution object representation in visual working memory.

  19. La superaci??n del modelo del ??ngel del hogar:

    OpenAIRE

    Hurtado Mu??oz, M??nica

    2012-01-01

    La Tesis Doctoral titulada "La superaci??n del modelo del "??ngel del hogar". Recuperaci??n de la escritora Leonor Canalejas y Fustegueras (1869-1945)" aborda, en primer lugar, un an??lisis sociol??gico de las circunstancias que rodearon a la mujer espa??ola en el cambio de siglo en el ??mbito social y educativo, en un intento de esclarecer las caracter??sticas propias del contexto en el que la mujer accede a la intelectualidad en general y a la literatura en particular. Esta parte concluye q...

  20. Prospective memory, working memory, retrospective memory and self-rated memory performance in persons with intellectual disability

    OpenAIRE

    Levén, Anna; Lyxell, Björn; Andersson, Jan; Danielsson, Henrik; Rönnberg, Jerker

    2008-01-01

    The purpose of the present study was to examine the relationship between prospective memory, working memory, retrospective memory and self-rated memory capacity in adults with and without intellectual disability. Prospective memory was investigated by means of a picture-based task. Working memory was measured as performance on span tasks. Retrospective memory was scored as recall of subject performed tasks. Self-ratings of memory performance were based on the prospective and retrospective mem...

  1. Main Memory DBMS

    NARCIS (Netherlands)

    P.A. Boncz (Peter); L. Liu (Lei); M. Tamer Özsu

    2008-01-01

    htmlabstractA main memory database system is a DBMS that primarily relies on main memory for computer data storage. In contrast, normal database management systems employ hard disk based persisntent storage.

  2. Coping with Memory Loss

    Science.gov (United States)

    ... Consumers Home For Consumers Consumer Updates Coping With Memory Loss Share Tweet Linkedin Pin it More sharing ... be evaluated by a health professional. What Causes Memory Loss? Anything that affects cognition—the process of ...

  3. Memory and Aging

    Science.gov (United States)

    Memory and Aging Losing keys, misplacing a wallet, or forgetting someone’s name are common experiences. But for people nearing or over age 65, such memory lapses can be frightening. They wonder if they ...

  4. Tracing Cultural Memory

    DEFF Research Database (Denmark)

    Wiegand, Frauke Katharina

    by their encounters – to address a question that thirty years of ground - breaking research into memory has not yet sufficiently answered: What can we learn about the dynamics of cultural memory by examining mundane accounts of touristic encounters with sites of memory? From Blaavand Beach in Western Denmark......We encounter, relate to and make use of our past and that of others in multifarious and increasingly mobile ways. Tourism is one of the main paths for encountering sites of memory. This thesis examines tourists’ creative appropriations of sites of memory – the objects and future memories inspired...... of memory. They highlight the role of mundane uses of the past and indicate the need for cross - disciplinary research on the visual and on memory...

  5. Emotional Memory Persists Longer than Event Memory

    Science.gov (United States)

    Kuriyama, Kenichi; Soshi, Takahiro; Fujii, Takeshi; Kim, Yoshiharu

    2010-01-01

    The interaction between amygdala-driven and hippocampus-driven activities is expected to explain why emotion enhances episodic memory recognition. However, overwhelming behavioral evidence regarding the emotion-induced enhancement of immediate and delayed episodic memory recognition has not been obtained in humans. We found that the recognition…

  6. Music, memory and emotion

    Science.gov (United States)

    Jäncke, Lutz

    2008-01-01

    Because emotions enhance memory processes and music evokes strong emotions, music could be involved in forming memories, either about pieces of music or about episodes and information associated with particular music. A recent study in BMC Neuroscience has given new insights into the role of emotion in musical memory. PMID:18710596

  7. Attending to auditory memory.

    Science.gov (United States)

    Zimmermann, Jacqueline F; Moscovitch, Morris; Alain, Claude

    2016-06-01

    Attention to memory describes the process of attending to memory traces when the object is no longer present. It has been studied primarily for representations of visual stimuli with only few studies examining attention to sound object representations in short-term memory. Here, we review the interplay of attention and auditory memory with an emphasis on 1) attending to auditory memory in the absence of related external stimuli (i.e., reflective attention) and 2) effects of existing memory on guiding attention. Attention to auditory memory is discussed in the context of change deafness, and we argue that failures to detect changes in our auditory environments are most likely the result of a faulty comparison system of incoming and stored information. Also, objects are the primary building blocks of auditory attention, but attention can also be directed to individual features (e.g., pitch). We review short-term and long-term memory guided modulation of attention based on characteristic features, location, and/or semantic properties of auditory objects, and propose that auditory attention to memory pathways emerge after sensory memory. A neural model for auditory attention to memory is developed, which comprises two separate pathways in the parietal cortex, one involved in attention to higher-order features and the other involved in attention to sensory information. This article is part of a Special Issue entitled SI: Auditory working memory. Copyright © 2015 Elsevier B.V. All rights reserved.

  8. Saving Malta's music memory

    OpenAIRE

    Sant, Toni

    2013-01-01

    Maltese music is being lost. Along with it Malta loses its culture, way of life, and memories. Dr Toni Sant is trying to change this trend through the Malta Music Memory Project (M3P) http://www.um.edu.mt/think/saving-maltas-music-memory-2/

  9. Associative Memory Acceptors.

    Science.gov (United States)

    Card, Roger

    The properties of an associative memory are examined in this paper from the viewpoint of automata theory. A device called an associative memory acceptor is studied under real-time operation. The family "L" of languages accepted by real-time associative memory acceptors is shown to properly contain the family of languages accepted by one-tape,…

  10. Generation and Context Memory

    Science.gov (United States)

    Mulligan, Neil W.; Lozito, Jeffrey P.; Rosner, Zachary A.

    2006-01-01

    Generation enhances memory for occurrence but may not enhance other aspects of memory. The present study further delineates the negative generation effect in context memory reported in N. W. Mulligan (2004). First, the negative generation effect occurred for perceptual attributes of the target item (its color and font) but not for extratarget…

  11. Music, memory and emotion.

    Science.gov (United States)

    Jäncke, Lutz

    2008-08-08

    Because emotions enhance memory processes and music evokes strong emotions, music could be involved in forming memories, either about pieces of music or about episodes and information associated with particular music. A recent study in BMC Neuroscience has given new insights into the role of emotion in musical memory.

  12. Communication skills training: describing a new conceptual model.

    Science.gov (United States)

    Brown, Richard F; Bylund, Carma L

    2008-01-01

    Current research in communication in physician-patient consultations is multidisciplinary and multimethodological. As this research has progressed, a considerable body of evidence on the best practices in physician-patient communication has been amassed. This evidence provides a foundation for communication skills training (CST) at all levels of medical education. Although the CST literature has demonstrated that communication skills can be taught, one critique of this literature is that it is not always clear which skills are being taught and whether those skills are matched with those being assessed. The Memorial Sloan-Kettering Cancer Center Comskil Model for CST seeks to answer those critiques by explicitly defining the important components of a consultation, based on Goals, Plans, and Actions theories and sociolinguistic theory. Sequenced guidelines as a mechanism for teaching about particular communication challenges are adapted from these other methods. The authors propose that consultation communication can be guided by an overarching goal, which is achieved through the use of a set of predetermined strategies. Strategies are common in CST; however, strategies often contain embedded communication skills. These skills can exist across strategies, and the Comskil Model seeks to make them explicit in these contexts. Separate from the skills are process tasks and cognitive appraisals that need to be addressed in teaching. The authors also describe how assessment practices foster concordance between skills taught and those assessed through careful coding of trainees' communication encounters and direct feedback.

  13. Ewing sarcoma in adults treated with modern radiotherapy techniques

    International Nuclear Information System (INIS)

    Casey, Dana L.; Meyers, Paul A.; Alektiar, Kaled M.; Magnan, Heather; Healey, John H.; Boland, Patrick J.; Wolden, Suzanne L.

    2014-01-01

    Background and purpose: To evaluate local control and survival outcomes in adults with Ewing sarcoma (ES) treated with radiotherapy (RT). Material and methods: Retrospective review of all 109 patients age ⩾18 treated for ES with RT to the primary site at Memorial Sloan Kettering Cancer Center between 1990 and 2011. RT was used as the definitive local control modality in 44% of patients, preoperatively for 6%, and postoperatively for 50%. Results: Median age at diagnosis was 27 years (range, 18–67). The 5-year local failure (LF) was 18%. Differences in LF were not identified when evaluated by modality of local control (RT versus combined surgery and RT), RT dose, fractionation, and RT technique. However, margin status at time of resection significantly predicted LF. The 5-year event-free survival and overall survival rates were 44% and 66% for patients with localized disease, compared with 16% and 26% for metastatic disease (p = 0.0005 and 0.0002). Tumor size, histopathologic response to chemotherapy, and treatment on or according to a protocol were also significantly associated with survival. Conclusions: This series of adults treated with modern chemotherapy and RT had prognostic factors and outcomes similar to adolescents with ES. All adults with ES should be treated with an aggressive, multidisciplinary approach

  14. Manifesto: towards a clinically-oriented psychometrics.

    Science.gov (United States)

    Vickers, Andrew J; Chen, Ling Y

    2017-04-26

    New technologies to collect patient - reported outcomes have substantially solved the challenge of integrating a questionnaire in a busy clinical practice. At Memorial Sloan Kettering, we have been collecting patient reported outcomes electronically for many years. Our experience confirms the predicted benefits of obtaining patient reported outcomes but has also raised serious concerns about whether instruments developed for the research setting are appropriate for routine clinical use. We summarize four principles for a clinically - relevant psychometrics. First, minimize patient burden: the use of a large number of items for a single domain may be of interest for research but additional items have little clinical utility. Secondly, use simplified language: patients who do not have good language skills are typically excluded from research studies but will nonetheless present in clinical practice. Third, avoid dumb questions: many questionnaire items are inappropriate when applied to a more general population. Fourth, what works for the group may not work for the individual: group level statistics used to validate survey instruments can obscure problems when applied to a subgroup of patients. There is a need for a clinically-oriented psychometrics to help design, test, and evaluate questionnaires that would be used in routine practice. Developing statistical methods to optimize questionnaires will be highly challenging but needed to bring the potential of patient reported outcomes into widespread clinical use.

  15. Exploring cell apoptosis and senescence to understand and treat cancer: an interview with Scott Lowe

    Directory of Open Access Journals (Sweden)

    2015-11-01

    Full Text Available Scott W. Lowe is currently principal investigator at the Memorial Sloan-Kettering Cancer Center. After beginning his studies in chemical engineering, he decided to take another path and became fascinated by biochemistry, genetics and molecular biology, which ultimately led to an interest in human disease, particularly cancer. During his PhD at the Massachusetts Institute of Technology (MIT, Scott had the opportunity to benefit from the exceptional mentorship of Earl Ruley, David Housman and Tyler Jacks, and contributed to elucidating how the p53 (TP53 tumor suppressor gene limits oncogenic transformation and modulates the cytotoxic response to conventional chemotherapy. This important work earned him a fellowship from the Cold Spring Harbor Laboratory, which helped to launch his independent career. Scott is now a leading scientist in the cancer field and his work has helped to shed light on mechanisms of cell apoptosis and senescence to better understand and treat cancer. In this interview, he talks about this incredible scientific journey.

  16. The Public Health Impact of Herbs and Nutritional Supplements

    Science.gov (United States)

    Cassileth, Barrie R.; Heitzer, Marjet; Wesa, Kathleen

    2009-01-01

    Dietary supplement use has increased exponentially in recent years despite the lack of regulatory oversight and in the face of growing safety concerns. This paper provides an overview of the public health implications and safety concerns associated with dietary supplement use, especially by cancer patients. Botanical research is actively pursued at the Memorial Sloan-Kettering Cancer Center (MSKCC) Integrative Medicine department. Work of the MSKCC Center for the Study of Botanical Immunomodulators is described, and guidelines for cancer patients’ use of dietary supplements outlined. Herbs and other botanicals are complex, physiologically active agents, but little is known about most of the popular, widely available dietary supplements. Herb-drug interactions, a major concern, are exacerbated in the cancer setting. Biologically active agents may interfere with chemotherapy and other prescription medications. They may exert anti-coagulant activity at rather inconvenient times such as during surgery, and create other serious problems. Research on the bioavailability, effective dosage, safety and benefits of these complex agents is sorely needed. Oncology professionals and other healthcare providers should educate themselves and their patients about these issues. Probably the largest, continuously-updated free information resource is MSKCC’s AboutHerbs website (www.mskcc.org/AboutHerbs). PMID:19890479

  17. CheckMate 025 Randomized Phase 3 Study: Outcomes by Key Baseline Factors and Prior Therapy for Nivolumab Versus Everolimus in Advanced Renal Cell Carcinoma.

    Science.gov (United States)

    Escudier, Bernard; Sharma, Padmanee; McDermott, David F; George, Saby; Hammers, Hans J; Srinivas, Sandhya; Tykodi, Scott S; Sosman, Jeffrey A; Procopio, Giuseppe; Plimack, Elizabeth R; Castellano, Daniel; Gurney, Howard; Donskov, Frede; Peltola, Katriina; Wagstaff, John; Gauler, Thomas C; Ueda, Takeshi; Zhao, Huanyu; Waxman, Ian M; Motzer, Robert J

    2017-12-01

    The randomized, phase 3 CheckMate 025 study of nivolumab (n=410) versus everolimus (n=411) in previously treated adults (75% male; 88% white) with advanced renal cell carcinoma (aRCC) demonstrated significantly improved overall survival (OS) and objective response rate (ORR). To investigate which baseline factors were associated with OS and ORR benefit with nivolumab versus everolimus. Subgroup OS analyses were performed using Kaplan-Meier methodology. Hazard ratios were estimated using the Cox proportional hazards model. Nivolumab 3mg/kg every 2 wk or everolimus 10mg once daily. The minimum follow-up was 14 mo. Baseline subgroup distributions were balanced between nivolumab and everolimus arms. Nivolumab demonstrated an OS improvement versus everolimus across subgroups, including Memorial Sloan Kettering Cancer Center (MSKCC) and International Metastatic Renal Cell Carcinoma Database Consortium risk groups; age guide treatment decisions, and further supports nivolumab as the standard of care in previously treated patients with aRCC. We investigated the impact of demographic and pretreatment features on survival benefit and tumor response with nivolumab versus everolimus in advanced renal cell carcinoma (aRCC). Survival benefit and response were observed for multiple subgroups, supporting the use of nivolumab as a new standard of care across a broad range of patients with previously treated aRCC. The trial is registered on ClinicalTrials.gov as NCT01668784. Copyright © 2017 European Association of Urology. Published by Elsevier B.V. All rights reserved.

  18. Cancer surgeons' distress and well-being, II: modifiable factors and the potential for organizational interventions.

    Science.gov (United States)

    Guest, Rebecca S; Baser, Ray; Li, Yuelin; Scardino, Peter T; Brown, Arthur E; Kissane, David W

    2011-05-01

    We showed in a companion paper that the prevalence of burnout among surgical oncologists at a comprehensive cancer center was 42% and psychiatric morbidity 27%, and high quality of life (QOL) was absent for 54% of surgeons. Here we examine modifiable workplace factors and other stressors associated with burnout, psychiatric morbidity, and low QOL, together with interest in interventions to reduce distress and improve wellness. Study-specific questions important for morale, QOL, and stressors associated with burnout were included in an anonymous Internet-based survey distributed to the surgical faculty at Memorial Sloan-Kettering Cancer Center. Among the 72 surgeons who responded (response rate of 73%), surgeons identified high stress from medical lawsuits, pressure to succeed in research, financial worries, negative attitudes to gender, and ability to cope with patients' suffering and death. Workplace features requiring greatest change were the reimbursement system, administrative support, and schedule. Work-life balance and relationship issues with spouse or partner caused high stress. Strongest correlations with distress were a desire to change communication with patients and the tension between the time devoted to work versus time available to be with family. Surgeons' preferences for interventions favored a fitness program, nutrition consultation, and increased socialization with colleagues, with less interest in interventions conventionally used to address psychological distress. Several opportunities to intervene at the organizational level permit efforts to reduce burnout and improve QOL.

  19. Electronic patient self-assessment and management (SAM): a novel framework for cancer survivorship.

    Science.gov (United States)

    Vickers, Andrew J; Salz, Talya; Basch, Ethan; Cooperberg, Matthew R; Carroll, Peter R; Tighe, Foss; Eastham, James; Rosen, Raymond C

    2010-06-17

    We propose a novel framework for management of cancer survivorship: electronic patient Self-Assessment and Management (SAM). SAM is a framework for transfer of information to and from patients in such a way as to increase both the patient's and the health care provider's understanding of the patient's progress, and to help ensure that patient care follows best practice. Patients who participate in the SAM system are contacted by email at regular intervals and asked to complete validated questionnaires online. Patient responses on these questionnaires are then analyzed in order to provide patients with real-time, online information about their progress and to provide them with tailored and standardized medical advice. Patient-level data from the questionnaires are ported in real time to the patient's health care provider to be uploaded to clinic notes. An initial version of SAM has been developed at Memorial Sloan-Kettering Cancer Center (MSKCC) and the University of California, San Francisco (UCSF) for aiding the clinical management of patients after surgery for prostate cancer. Pilot testing at MSKCC and UCSF suggests that implementation of SAM systems are feasible, with no major problems with compliance (> 70% response rate) or security. SAM is a conceptually simple framework for passing information to and from patients in such a way as to increase both the patient's and the health care provider's understanding of the patient's progress, and to help ensure that patient care follows best practice.

  20. Prognostic relevance of sunitinib toxicities and comparison of continuous vs. intermittent sunitinib dosing schedule in metastatic renal cell cancer patients

    Directory of Open Access Journals (Sweden)

    Çetin Ordu

    2016-06-01

    Full Text Available Aim of the study : Sunitinib-related side effects may develop as a result of the pharmacokinetic pathway affects the of the drug. Material and methods : Data on mRCC patients were obtained from the hospital archives. Outcomes of patients were evaluated in terms of related prognostic factors, sunitinib adverse events during the treatment, and two different sunitinib dosing schedules. Results : Seventy patients diagnosed with mRCC and treated with sunitinib were analyzed for prognostic factors and survival rates. During the mean follow-up of 33.5 months, 38 (54% patients were alive and 32 (46% patients died. The median time of overall survival (OS and progression-free survival (PFS was 27 months (12–61 and 19 months (5–45, respectively. In univariate analysis, good prognostic risk group according to the Memorial Sloan-Kettering Cancer Center (MSKCC, hypothyroidism as sunitinib toxicity and patients on sunitinib treatment more than 1 year were favorable prognostic factors for OS. Leukopenia and fatigue as sunitinib toxicity were poor prognostic factors for OS. PFS and OS of the patients were not significantly different when we compared intermittent (4/2 vs. continuous treatment dosing schedules. Conclusions : As a result of this trial, having hypothyroidism as an adverse effect of sunitinib was a favorable prognostic factor for OS and PFS in mRCC patients. It was also found that 4/2 and continuous dosing schedules of sunitinib did not give rise to different outcomes in mRCC patients.

  1. Post-operative hemimaxillectomy rehabilitation using prostheses supported by zygoma implants and remaining natural teeth

    Directory of Open Access Journals (Sweden)

    Xing Zhou Qu

    Full Text Available OBJECTIVES: This study aimed to evaluate the stability of prostheses supported by zygoma implants and remaining teeth for subjects who had undergone hemi-maxillectomy. METHODS: Ten patients were included in the study. Oral rehabilitation was performed using a temporary prosthesis that was supported by remaining teeth for the first three months. Then, a zygoma implant was placed to provide support for a final prosthesis in addition to the remaining teeth. Each prosthesis was tailor-made according to biomechanical three-dimensional finite element analysis results. The patients were assessed using the prosthesis functioning scale of the Memorial Sloan-Kettering Cancer Center. In addition, retention and bite force were recorded for both the temporary prosthesis and the final prosthesis. RESULTS: The mean bite force of the prosthetic first molar was increased to 69.2 N. The mean retentive force increased to 13.5 N after zygoma implant insertion. The bite force on the prosthetic first molar was improved to 229.3 N. CONCLUSION: Bite force increased significantly with the support of a zygoma implant. The use of zygoma implants in the restoration of maxillary defects improved functional outcome and patient satisfaction.

  2. Variability in Predictions from Online Tools: A Demonstration Using Internet-Based Melanoma Predictors.

    Science.gov (United States)

    Zabor, Emily C; Coit, Daniel; Gershenwald, Jeffrey E; McMasters, Kelly M; Michaelson, James S; Stromberg, Arnold J; Panageas, Katherine S

    2018-02-22

    Prognostic models are increasingly being made available online, where they can be publicly accessed by both patients and clinicians. These online tools are an important resource for patients to better understand their prognosis and for clinicians to make informed decisions about treatment and follow-up. The goal of this analysis was to highlight the possible variability in multiple online prognostic tools in a single disease. To demonstrate the variability in survival predictions across online prognostic tools, we applied a single validation dataset to three online melanoma prognostic tools. Data on melanoma patients treated at Memorial Sloan Kettering Cancer Center between 2000 and 2014 were retrospectively collected. Calibration was assessed using calibration plots and discrimination was assessed using the C-index. In this demonstration project, we found important differences across the three models that led to variability in individual patients' predicted survival across the tools, especially in the lower range of predictions. In a validation test using a single-institution data set, calibration and discrimination varied across the three models. This study underscores the potential variability both within and across online tools, and highlights the importance of using methodological rigor when developing a prognostic model that will be made publicly available online. The results also reinforce that careful development and thoughtful interpretation, including understanding a given tool's limitations, are required in order for online prognostic tools that provide survival predictions to be a useful resource for both patients and clinicians.

  3. Australia-wide comparison of intensity modulated radiation therapy prostate plans

    International Nuclear Information System (INIS)

    Skala, M.; Holloway, L.; Bailey, M.; Kneebone, A.

    2005-01-01

    The aim of this study was to investigate the ability of Australian centres to produce high-dose intensity modulated radiation therapy (IMRT) prostate plans, and to compare the planning parameters and resultant dose distributions. Five Australian radiation therapy departments were invited to participate. Each centre received an identical 5 mm-slice CT data set complete with contours of the prostate, seminal vesicles, rectum, bladder, femoral heads and body outline. The planning team was asked to produce the best plan possible, using published Memorial Sloan-Kettering Cancer Centre prescription and dose constraints. Three centres submitted plans for evaluation. All plans covered the planning target volume adequately; however, only one plan met all the critical organ dose constraints. Although the planning parameters, beam arrangements and planning systems were different for each centre, the resulting plans were similar. In Australia, IMRT for prostate cancer is in the early stages of implementation, with routine use limited to a few centres. Copyright (2005) Blackwell Science Pty Ltd

  4. Serious Infections in Patients Receiving Ibrutinib for Treatment of Lymphoid Malignancies.

    Science.gov (United States)

    Varughese, Tilly; Taur, Ying; Cohen, Nina; Palomba, M Lia; Seo, Susan K; Hohl, Tobias M; Redelman-Sidi, Gil

    2018-03-02

    Ibrutinib is a Bruton's tyrosine kinase inhibitor that is used for the treatment of lymphoid malignancies, including chronic lymphocytic leukemia (CLL), Waldenström's macroglobulinemia and mantle cell lymphoma (MCL). Several case series have described opportunistic infections among ibrutinib recipients, but the full extent of these infections is unknown. We sought to determine the spectrum of serious infections associated with ibrutinib treatment. We reviewed the electronic medical records of patients with lymphoid malignancies at Memorial Sloan Kettering Cancer Center who received ibrutinib during a five-year period from January 1, 2012 to December 31, 2016. Serious infections were identified by review of the relevant microbiology, clinical laboratory, and radiology data. Risk factors for infection were determined by univariate and multivariate analyses. 378 patients with lymphoid malignancies who received ibrutinib were analyzed. The most common underlying malignancies were CLL and MCL. 84% of patients received ibrutinib as monotherapy. Serious infection developed in 43 patients (11.4%), primarily during the first year of ibrutinib treatment. Of these, 23 (53.5%) developed invasive bacterial infections, and 16 (37.2%) developed invasive fungal infections (IFI). The majority of those who developed IFI on ibrutinib therapy (62.5%) lacked classical clinical risk factors for fungal infection (i.e., neutropenia, lymphopenia, and receipt of corticosteroids). Infection resulted in death in six of the 43 patients (14%). Patients with lymphoid malignancies receiving ibrutinib treatment are at risk for serious infections, including IFI.

  5. Low-dose-rate brachytherapy for patients with transurethral resection before implantation in prostate cancer: long-term results

    International Nuclear Information System (INIS)

    Prada, Pedro J.; Anchuelo, Javier; Blanco, Ana Garcia; Paya, Gema; Cardenal, Juan; Acuña, Enrique; Ferri, Maria; Vazquez, Andres; Pacheco, Maite; Sanchez, Jesica

    2016-01-01

    Objectives: We analyzed the long-term oncologic outcome for patients with prostate cancer and transurethral resection who were treated using low-dose-rate (LDR) prostate brachytherapy. Methods and Materials: From January 2001 to December 2005, 57 consecutive patients were treated with clinically localized prostate cancer. No patients received external beam radiation. All of them underwent LDR prostate brachytherapy. Biochemical failure was defined according to the 'Phoenix consensus'. Patients were stratified as low and intermediate risk based on The Memorial Sloan Kettering group definition. Results: The median follow-up time for these 57 patients was 104 months. The overall survival according to Kaplan-Meier estimates was 88% (±6%) at 5 years and 77% (±6%) at 12 years. The 5 and 10 years for failure in tumour-free survival (TFS) was 96% and respectively (±2%), whereas for biochemical control was 94% and respectively (±3%) at 5 and 10 years, 98% (±1%) of patients being free of local recurrence. A patient reported incontinence after treatment (1.7%). The chronic genitourinary complains grade I were 7% and grade II, 10%. At six months 94% of patients reported no change in bowel function. Conclusions: The excellent long-term results and low morbidity presented, as well as the many advantages of prostate brachytherapy over other treatments, demonstrates that brachytherapy is an effective treatment for patients with transurethral resection and clinical organ-confined prostate cancer. (author)

  6. Tumor mutational load and immune parameters across metastatic Renal Cell Carcinoma (mRCC) risk groups

    Science.gov (United States)

    de Velasco, Guillermo; Miao, Diana; Voss, Martin H.; Hakimi, A. Ari; Hsieh, James J.; Tannir, Nizar M.; Tamboli, Pheroze; Appleman, Leonard J.; Rathmell, W. Kimryn; Van Allen, Eliezer M.; Choueiri, Toni K.

    2016-01-01

    Patients with metastatic renal cell carcinoma (mRCC) have better overall survival when treated with nivolumab, a cancer immunotherapy that targets the immune checkpoint inhibitor programmed cell death 1 (PD-1), rather than everolimus (a chemical inhibitor of mTOR and immunosuppressant). Poor-risk mRCC patients treated with nivolumab seemed to experience the greatest overall survival benefit, compared to patients with favorable or intermediate-risk, in an analysis of the CheckMate-025 trial subgroup of the Memorial Sloan Kettering Cancer Center (MSKCC) prognostic risk groups. Here we explore whether tumor mutational load and RNA expression of specific immune parameters could be segregated by prognostic MSKCC risk strata and explain the survival seen in the poor-risk group. We queried whole exome transcriptome data in RCC patients (n = 54) included in The Cancer Genome Atlas that ultimately developed metastatic disease or were diagnosed with metastatic disease at presentation and did not receive immune checkpoint inhibitors. Nonsynonymous mutational load did not differ significantly by MSKCC risk group, nor was the expression of cytolytic genes –granzyme A and perforin – or selected immune checkpoint molecules different across MSKCC risk groups. In conclusion, this analysis found that mutational load and expression of markers of an active tumor microenvironment did not correlate with MSKCC risk prognostic classification in mRCC. PMID:27538576

  7. Exploring cell apoptosis and senescence to understand and treat cancer: an interview with Scott Lowe.

    Science.gov (United States)

    Lowe, Scott; Cifra, Alessandra

    2015-11-01

    Scott W. Lowe is currently principal investigator at the Memorial Sloan-Kettering Cancer Center. After beginning his studies in chemical engineering, he decided to take another path and became fascinated by biochemistry, genetics and molecular biology, which ultimately led to an interest in human disease, particularly cancer. During his PhD at the Massachusetts Institute of Technology (MIT), Scott had the opportunity to benefit from the exceptional mentorship of Earl Ruley, David Housman and Tyler Jacks, and contributed to elucidating how the p53 (TP53) tumor suppressor gene limits oncogenic transformation and modulates the cytotoxic response to conventional chemotherapy. This important work earned him a fellowship from the Cold Spring Harbor Laboratory, which helped to launch his independent career. Scott is now a leading scientist in the cancer field and his work has helped to shed light on mechanisms of cell apoptosis and senescence to better understand and treat cancer. In this interview, he talks about this incredible scientific journey. © 2015. Published by The Company of Biologists Ltd.

  8. 15-Year biochemical relapse free survival in clinical Stage T1-T3 prostate cancer following combined external beam radiotherapy and brachytherapy; Seattle experience

    International Nuclear Information System (INIS)

    Sylvester, John E.; Grimm, Peter D.; Blasko, John C.; Millar, Jeremy; Orio, Peter F.; Skoglund, Scott; Galbreath, Robert W.; Merrick, Gregory

    2007-01-01

    Purpose: Long-term biochemical relapse-free survival (BRFS) rates in patients with clinical Stages T1-T3 prostate cancer continue to be scrutinized after treatment with external beam radiation therapy and brachytherapy. Methods and Materials: We report 15-year BRFS rates on 223 patients with clinically localized prostate cancer that were consecutively treated with I 125 or Pd 103 brachytherapy after 45-Gy neoadjuvant EBRT. Multivariate regression analysis was used to create a pretreatment clinical prognostic risk model using a modified American Society for Therapeutic Radiology and Oncology consensus definition (two consecutive serum prostate-specific antigen rises) as the outcome. Gleason scoring was performed by the pathologists at a community hospital. Time to biochemical failure was calculated and compared by using Kaplan-Meier plots. Results: Fifteen-year BRFS for the entire treatment group was 74%. BRFS using the Memorial Sloan-Kettering risk cohort analysis (95% confidence interval): low risk, 88%, intermediate risk 80%, and high risk 53%. Grouping by the risk classification described by D'Amico, the BRFS was: low risk 85.8%, intermediate risk 80.3%, and high risk 67.8% (p = 0.002). Conclusions: I 125 or Pd 103 brachytherapy combined with supplemental EBRT results in excellent 15-year biochemical control. Different risk group classification schemes lead to different BRFS results in the high-risk group cohorts

  9. Optimal needle arrangement for intraoperative planning in permanent I-125 prostate implants

    International Nuclear Information System (INIS)

    Thompson, S.A.; Fung, A.Y.C.; Zaider, M.

    2002-01-01

    One limitation of intraoperative planning of permanent prostate implants is that needles must already be in the gland before planning images are acquired. Improperly placed needles often restrict the capability of generating optimal seed placement. We developed guiding principles for the proper layout of needles within the treatment volume. The Memorial Sloan-Kettering Cancer Center planning system employs a genetic algorithm to find the optimal seed implantation pattern consistent with pre-assigned constraints (needle geometry, uniformity, conformity and the avoidance of high doses to urethra and rectum). Ultrasound volumes for twelve patients with I-125 implants were used to generate six plans per patient (total 72 plans) with different needle arrangements. The plans were evaluated in terms of V100 (percentage prostate volume receiving at least the prescription dose), U135 (percentage urethra volume receiving at least 135% of prescription dose), and CI (conformity index, the ratio of treatment volume to prescription dose volume.) The method termed POSTCTR, in which needles were placed on the periphery of the largest ultrasound slice and posterior central needles were placed as needed, consistently gave superior results for all prostate sizes. Another arrangement, labelled POSTLAT, where the needles were placed peripherally with additional needles in the posterior lateral lobes, also gave satisfactory results. We advocate two needle arrangements, POSTCTR and POSTLAT, with the former giving better results. (author)

  10. NOTE: Optimal needle arrangement for intraoperative planning in permanent I-125 prostate implants

    Science.gov (United States)

    Thompson, S. A.; Fung, A. Y. C.; Zaider, M.

    2002-08-01

    One limitation of intraoperative planning of permanent prostate implants is that needles must already be in the gland before planning images are acquired. Improperly placed needles often restrict the capability of generating optimal seed placement. We developed guiding principles for the proper layout of needles within the treatment volume. The Memorial Sloan-Kettering Cancer Center planning system employs a genetic algorithm to find the optimal seed implantation pattern consistent with pre-assigned constraints (needle geometry, uniformity, conformity and the avoidance of high doses to urethra and rectum). Ultrasound volumes for twelve patients with I-125 implants were used to generate six plans per patient (total 72 plans) with different needle arrangements. The plans were evaluated in terms of V100 (percentage prostate volume receiving at least the prescription dose), U135 (percentage urethra volume receiving at least 135% of prescription dose), and CI (conformity index, the ratio of treatment volume to prescription dose volume.) The method termed POSTCTR, in which needles were placed on the periphery of the largest ultrasound slice and posterior central needles were placed as needed, consistently gave superior results for all prostate sizes. Another arrangement, labelled POSTLAT, where the needles were placed peripherally with additional needles in the posterior lateral lobes, also gave satisfactory results. We advocate two needle arrangements, POSTCTR and POSTLAT, with the former giving better results.

  11. Optimal needle arrangement for intraoperative planning in permanent I-125 prostate implants

    Energy Technology Data Exchange (ETDEWEB)

    Thompson, S.A. [Department of Medical Physics, North Shore-Long Island Jewish Health System, Manhassett, NY (United States); Fung, A.Y.C.; Zaider, M. [Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, NY (United States)

    2002-08-21

    One limitation of intraoperative planning of permanent prostate implants is that needles must already be in the gland before planning images are acquired. Improperly placed needles often restrict the capability of generating optimal seed placement. We developed guiding principles for the proper layout of needles within the treatment volume. The Memorial Sloan-Kettering Cancer Center planning system employs a genetic algorithm to find the optimal seed implantation pattern consistent with pre-assigned constraints (needle geometry, uniformity, conformity and the avoidance of high doses to urethra and rectum). Ultrasound volumes for twelve patients with I-125 implants were used to generate six plans per patient (total 72 plans) with different needle arrangements. The plans were evaluated in terms of V100 (percentage prostate volume receiving at least the prescription dose), U135 (percentage urethra volume receiving at least 135% of prescription dose), and CI (conformity index, the ratio of treatment volume to prescription dose volume.) The method termed POSTCTR, in which needles were placed on the periphery of the largest ultrasound slice and posterior central needles were placed as needed, consistently gave superior results for all prostate sizes. Another arrangement, labelled POSTLAT, where the needles were placed peripherally with additional needles in the posterior lateral lobes, also gave satisfactory results. We advocate two needle arrangements, POSTCTR and POSTLAT, with the former giving better results. (author)

  12. Implanted Cardiac Defibrillator Care in Radiation Oncology Patient Population

    International Nuclear Information System (INIS)

    Gelblum, Daphna Y.; Amols, Howard

    2009-01-01

    Purpose: To review the experience of a large cancer center with radiotherapy (RT) patients bearing implantable cardiac defibrillators (ICDs) to propose some preliminary care guidelines as we learn more about the devices and their interaction with the therapeutic radiation environment. Methods and Materials: We collected data on patients with implanted ICDs treated with RT during a 2.5-year period at any of the five Memorial Sloan-Kettering clinical campuses. Information regarding the model, location, and dose detected from the device, as well as the treatment fields, fraction size, and treatment energy was collected. During this time, a new management policy for these patients had been implemented requiring treatment with low-energy beams (6 MV) and close surveillance of the patients in partnership with their electrophysiologist, as they received RT. Results: During the study period, 33 patients were treated with an ICD in place. One patient experienced a default of the device to its initial factory setting that was detected by the patient hearing an auditory signal from the device. This patient had initially been treated with a 15-MV beam. After this episode, his treatment was replanned to be completed with 6-MV photons, and he experienced no further events. Conclusion: Patients with ICDs and other implanted computer-controlled devices will be encountered more frequently in the RT department, and proper management is important. We present a policy for the safe treatment of these patients in the radiation oncology environment.

  13. Whole Blood mRNA Expression-Based Prognosis of Metastatic Renal Cell Carcinoma.

    Science.gov (United States)

    Giridhar, Karthik V; Sosa, Carlos P; Hillman, David W; Sanhueza, Cristobal; Dalpiaz, Candace L; Costello, Brian A; Quevedo, Fernando J; Pitot, Henry C; Dronca, Roxana S; Ertz, Donna; Cheville, John C; Donkena, Krishna Vanaja; Kohli, Manish

    2017-11-03

    The Memorial Sloan Kettering Cancer Center (MSKCC) prognostic score is based on clinical parameters. We analyzed whole blood mRNA expression in metastatic clear cell renal cell carcinoma (mCCRCC) patients and compared it to the MSKCC score for predicting overall survival. In a discovery set of 19 patients with mRCC, we performed whole transcriptome RNA sequencing and selected eighteen candidate genes for further evaluation based on associations with overall survival and statistical significance. In an independent validation of set of 47 patients with mCCRCC, transcript expression of the 18 candidate genes were quantified using a customized NanoString probeset. Cox regression multivariate analysis confirmed that two of the candidate genes were significantly associated with overall survival. Higher expression of BAG1 [hazard ratio (HR) of 0.14, p < 0.0001, 95% confidence interval (CI) 0.04-0.36] and NOP56 (HR 0.13, p < 0.0001, 95% CI 0.05-0.34) were associated with better prognosis. A prognostic model incorporating expression of BAG1 and NOP56 into the MSKCC score improved prognostication significantly over a model using the MSKCC prognostic score only ( p < 0.0001). Prognostic value of using whole blood mRNA gene profiling in mCCRCC is feasible and should be prospectively confirmed in larger studies.

  14. Whole Blood mRNA Expression-Based Prognosis of Metastatic Renal Cell Carcinoma

    Directory of Open Access Journals (Sweden)

    Karthik V. Giridhar

    2017-11-01

    Full Text Available The Memorial Sloan Kettering Cancer Center (MSKCC prognostic score is based on clinical parameters. We analyzed whole blood mRNA expression in metastatic clear cell renal cell carcinoma (mCCRCC patients and compared it to the MSKCC score for predicting overall survival. In a discovery set of 19 patients with mRCC, we performed whole transcriptome RNA sequencing and selected eighteen candidate genes for further evaluation based on associations with overall survival and statistical significance. In an independent validation of set of 47 patients with mCCRCC, transcript expression of the 18 candidate genes were quantified using a customized NanoString probeset. Cox regression multivariate analysis confirmed that two of the candidate genes were significantly associated with overall survival. Higher expression of BAG1 [hazard ratio (HR of 0.14, p < 0.0001, 95% confidence interval (CI 0.04–0.36] and NOP56 (HR 0.13, p < 0.0001, 95% CI 0.05–0.34 were associated with better prognosis. A prognostic model incorporating expression of BAG1 and NOP56 into the MSKCC score improved prognostication significantly over a model using the MSKCC prognostic score only (p < 0.0001. Prognostic value of using whole blood mRNA gene profiling in mCCRCC is feasible and should be prospectively confirmed in larger studies.

  15. Adult Rhabdomyosarcoma Survival Improved With Treatment on Multimodality Protocols

    International Nuclear Information System (INIS)

    Gerber, Naamit Kurshan; Wexler, Leonard H.; Singer, Samuel; Alektiar, Kaled M.; Keohan, Mary Louise; Shi, Weiji; Zhang, Zhigang; Wolden, Suzanne

    2013-01-01

    Purpose: Rhabdomyosarcoma (RMS) is a pediatric sarcoma rarely occurring in adults. For unknown reasons, adults with RMS have worse outcomes than do children. Methods and Materials: We analyzed data from all patients who presented to Memorial Sloan-Kettering Cancer Center between 1990 and 2011 with RMS diagnosed at age 16 or older. One hundred forty-eight patients met the study criteria. Ten were excluded for lack of adequate data. Results: The median age was 28 years. The histologic diagnoses were as follows: embryonal 54%, alveolar 33%, pleomorphic 12%, and not otherwise specified 2%. The tumor site was unfavorable in 67% of patients. Thirty-three patients (24%) were at low risk, 61 (44%) at intermediate risk, and 44 (32%) at high risk. Forty-six percent were treated on or according to a prospective RMS protocol. The 5-year rate of overall survival (OS) was 45% for patients with nonmetastatic disease. The failure rates at 5 years for patients with nonmetastatic disease were 34% for local failure and 42% for distant failure. Among patients with nonmetastatic disease (n=94), significant factors associated with OS were histologic diagnosis, site, risk group, age, and protocol treatment. On multivariate analysis, risk group and protocol treatment were significant after adjustment for age. The 5-year OS was 54% for protocol patients versus 36% for nonprotocol patients. Conclusions: Survival in adult patients with nonmetastatic disease was significantly improved for those treated on RMS protocols, most of which are now open to adults

  16. Electronic patient self-assessment and management (SAM: a novel framework for cancer survivorship

    Directory of Open Access Journals (Sweden)

    Tighe Foss

    2010-06-01

    Full Text Available Abstract Background We propose a novel framework for management of cancer survivorship: electronic patient Self-Assessment and Management (SAM. SAM is a framework for transfer of information to and from patients in such a way as to increase both the patient's and the health care provider's understanding of the patient's progress, and to help ensure that patient care follows best practice. Methods Patients who participate in the SAM system are contacted by email at regular intervals and asked to complete validated questionnaires online. Patient responses on these questionnaires are then analyzed in order to provide patients with real-time, online information about their progress and to provide them with tailored and standardized medical advice. Patient-level data from the questionnaires are ported in real time to the patient's health care provider to be uploaded to clinic notes. An initial version of SAM has been developed at Memorial Sloan-Kettering Cancer Center (MSKCC and the University of California, San Francisco (UCSF for aiding the clinical management of patients after surgery for prostate cancer. Results Pilot testing at MSKCC and UCSF suggests that implementation of SAM systems are feasible, with no major problems with compliance (> 70% response rate or security. Conclusion SAM is a conceptually simple framework for passing information to and from patients in such a way as to increase both the patient's and the health care provider's understanding of the patient's progress, and to help ensure that patient care follows best practice.

  17. Predictors of Bowel Function in Long-term Rectal Cancer Survivors with Anastomosis.

    Science.gov (United States)

    Alavi, Mubarika; Wendel, Christopher S; Krouse, Robert S; Temple, Larissa; Hornbrook, Mark C; Bulkley, Joanna E; McMullen, Carmit K; Grant, Marcia; Herrinton, Lisa J

    2017-11-01

    Bowel function in long-term rectal cancer survivors with anastomosis has not been characterized adequately. We hypothesized that bowel function is associated with patient, disease, and treatment characteristics. The cohort study included Kaiser Permanente members who were long-term (≥5 years) rectal cancer survivors with anastomosis. Bowel function was scored using the self-administered, 14-item Memorial Sloan-Kettering Cancer Center Bowel Function Index. Patient, cancer, and treatment variables were collected from the electronic medical chart. We used multiple regression to assess the relationship of patient- and treatment-related variables with the bowel function score. The study included 381 anastomosis patients surveyed an average 12 years after their rectal cancer surgeries. The total bowel function score averaged 53 (standard deviation, 9; range, 31-70, higher scores represent better function). Independent factors associated with worse total bowel function score included receipt of radiation therapy (yes vs. no: 5.3-unit decrement, p 6 cm: 3.2-unit decrement, p decrement, p decrement, p model explained 20% of the variation in the total bowel function score. Low tumor location, radiation therapy, temporary ostomy during initial treatment, and history of smoking were linked with decreased long-term bowel function following an anastomosis. These results should improve decision-making about surgical options.

  18. Improving cancer treatment with cyclotron produced radionuclides

    International Nuclear Information System (INIS)

    Laughlin, J.S.; Larson, S.M.

    1988-01-01

    This new DOE proposal appropriately builds on past developments. The development and application of radionuclides for diagnosis, treatment and research has been a continuing concern for more than the past three decades. A brief description of this development and previous achievements was considered important in order to provide a frame of reference for the evolving program here. Earlier, the use of certain radionuclides, radon progeny and I-131 in particular, and also x-rays, had been developed by the work of such pioneers as Failla, Quimby and Marinelli. In 1952, at the instigation of Dr. C.P. Rhoads, Director of both Memorial Hospital and Sloan-Kettering Institute, the restoration of the Department of Physics and Biophysics was undertaken in response to a perceived need to promote the utilization of radionuclides and of high energy radiations for therapeutic, diagnostic and research purposes. This resulted in several research and developmental projects with close clinical collaboration in areas of radiation treatment; medical studies with radionuclides and labeled compounds; the diagnostic uses of x-rays; and some projects in surgery and other clinical areas. Aspects of some of these projects that have had some relevance for the evolving AEC-DOE projects are outlined briefly. 34 refs

  19. Performance of a Nomogram Predicting Disease-Specific Survival After an R0 Resection for Gastric Cancer in Patients Receiving Postoperative Chemoradiation Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Dikken, Johan L. [Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Department of Surgery, Leiden University Medical Center, Leiden (Netherlands); Coit, Daniel G. [Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Baser, Raymond E.; Gönen, Mithat [Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Goodman, Karyn A. [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Brennan, Murray F. [Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Jansen, Edwin P.M. [Department of Radiotherapy, The Netherlands Cancer Institute–Antoni van Leeuwenhoek Hospital, Amsterdam (Netherlands); Boot, Henk [Department of Gastroenterology, The Netherlands Cancer Institute–Antoni van Leeuwenhoek Hospital, Amsterdam (Netherlands); Velde, Cornelis J.H. van de [Department of Surgery, Leiden University Medical Center, Leiden (Netherlands); Cats, Annemieke [Department of Gastroenterology, The Netherlands Cancer Institute–Antoni van Leeuwenhoek Hospital, Amsterdam (Netherlands); Verheij, Marcel, E-mail: m.verheij@nki.nl [Department of Radiotherapy, The Netherlands Cancer Institute–Antoni van Leeuwenhoek Hospital, Amsterdam (Netherlands)

    2014-03-01

    Purpose: The internationally validated Memorial Sloan-Kettering Cancer Center (MSKCC) gastric carcinoma nomogram was based on patients who underwent curative (R0) gastrectomy, without any other therapy. The purpose of the current study was to assess the performance of this gastric cancer nomogram in patients who received chemoradiation therapy after an R0 resection for gastric cancer. Methods and Materials: In a combined dataset of 76 patients from the Netherlands Cancer Institute (NKI), and 63 patients from MSKCC, who received postoperative chemoradiation therapy (CRT) after an R0 gastrectomy, the nomogram was validated by means of the concordance index (CI) and a calibration plot. Results: The concordance index for the nomogram was 0.64, which was lower than the CI of the nomogram for patients who received no adjuvant therapy (0.80). In the calibration plot, observed survival was approximately 20% higher than the nomogram-predicted survival for patients receiving postoperative CRT. Conclusions: The MSKCC gastric carcinoma nomogram significantly underpredicted survival for patients in the current study, suggesting an impact of postoperative CRT on survival in patients who underwent an R0 resection for gastric cancer, which has been demonstrated by randomized controlled trials. This analysis stresses the need for updating nomograms with the incorporation of multimodal strategies.

  20. Acute Skin Toxicity Following Stereotactic Body Radiation Therapy for Stage I Non-Small-Cell Lung Cancer: Who's at Risk?

    International Nuclear Information System (INIS)

    Hoppe, Bradford S.; Laser, Benjamin; Kowalski, Alex V.; Fontenla, Sandra C.; Pena-Greenberg, Elizabeth; Yorke, Ellen D.; Lovelock, D. Michael; Hunt, Margie A.; Rosenzweig, Kenneth E.

    2008-01-01

    Purpose: We examined the rate of acute skin toxicity within a prospectively managed database of patients treated for early-stage non-small-cell lung cancer (NSCLC) and investigated factors that might predict skin toxicity. Methods: From May 2006 through January 2008, 50 patients with Stage I NSCLC were treated at Memorial Sloan-Kettering Cancer Center with 60 Gy in three fractions or 44-48 Gy in four fractions. Patients were treated with multiple coplanar beams (3-7, median 4) with a 6 MV linac using intensity-modulated radiotherapy (IMRT) and dynamic multileaf collimation. Toxicity grading was performed and based on the National Cancer Institute Common Terminology Criteria for Adverse Effects. Factors associated with Grade 2 or higher acute skin reactions were calculated by Fisher's exact test. Results: After a minimum 3 months of follow-up, 19 patients (38%) developed Grade 1, 4 patients (8%) Grade 2, 2 patients (4%) Grade 3, and 1 patient Grade 4 acute skin toxicity. Factors associated with Grade 2 or higher acute skin toxicity included using only 3 beams (p = 0.0007), distance from the tumor to the posterior chest wall skin of less than 5 cm (p = 0.006), and a maximum skin dose of 50% or higher of the prescribed dose (p = 0.02). Conclusions: SBRT can be associated with significant skin toxicity. One must consider the skin dose when evaluating the treatment plan and consider the bolus effect of immobilization devices

  1. Control of norovirus outbreak on a pediatric oncology unit.

    Science.gov (United States)

    Sheahan, Anna; Copeland, Gretchen; Richardson, Lauren; McKay, Shelley; Chou, Alexander; Babady, N Esther; Tang, Yi-Wei; Boulad, Farid; Eagan, Janet; Sepkowitz, Kent; Kamboj, Mini

    2015-10-01

    Patients undergoing treatment for cancer with chemotherapy and hematopoietic stem cell recipients are at risk for severe morbidity caused by norovirus (NV). We describe a NV outbreak on the Memorial Sloan Kettering Cancer Center's pediatric oncology unit. Stool testing for diagnosis of NV was performed by real-time polymerase chain reaction (PCR). Twelve NV cases occurred; 7 were hospital acquired. Twenty-five health care workers reported NV compatible illness. Patient-to-patient transmission occurred once. The practices of the Centers for Disease Control and Prevention were supplemented with electronic surveillance, surrogate screening for NV, and heightened cleaning. Two additional cases occurred after implementation of interventions. Long-term shedding was detected in 2 patients. We describe interventions for controlling NV on a pediatric oncology unit. High-risk chronic shedders pose ongoing transmission risks. PCR is a valuable diagnostic tool but may be overly sensitive. Surrogate markers to assess NV burden in stool and studies on NV screening are needed to develop guidelines for high-risk chronic shedders. Copyright © 2015 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.

  2. Adult Rhabdomyosarcoma Survival Improved With Treatment on Multimodality Protocols

    Energy Technology Data Exchange (ETDEWEB)

    Gerber, Naamit Kurshan [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Wexler, Leonard H. [Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Singer, Samuel [Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Alektiar, Kaled M. [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Keohan, Mary Louise [Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Shi, Weiji; Zhang, Zhigang [Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Wolden, Suzanne, E-mail: woldens@mskcc.org [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States)

    2013-05-01

    Purpose: Rhabdomyosarcoma (RMS) is a pediatric sarcoma rarely occurring in adults. For unknown reasons, adults with RMS have worse outcomes than do children. Methods and Materials: We analyzed data from all patients who presented to Memorial Sloan-Kettering Cancer Center between 1990 and 2011 with RMS diagnosed at age 16 or older. One hundred forty-eight patients met the study criteria. Ten were excluded for lack of adequate data. Results: The median age was 28 years. The histologic diagnoses were as follows: embryonal 54%, alveolar 33%, pleomorphic 12%, and not otherwise specified 2%. The tumor site was unfavorable in 67% of patients. Thirty-three patients (24%) were at low risk, 61 (44%) at intermediate risk, and 44 (32%) at high risk. Forty-six percent were treated on or according to a prospective RMS protocol. The 5-year rate of overall survival (OS) was 45% for patients with nonmetastatic disease. The failure rates at 5 years for patients with nonmetastatic disease were 34% for local failure and 42% for distant failure. Among patients with nonmetastatic disease (n=94), significant factors associated with OS were histologic diagnosis, site, risk group, age, and protocol treatment. On multivariate analysis, risk group and protocol treatment were significant after adjustment for age. The 5-year OS was 54% for protocol patients versus 36% for nonprotocol patients. Conclusions: Survival in adult patients with nonmetastatic disease was significantly improved for those treated on RMS protocols, most of which are now open to adults.

  3. Low-dose-rate brachytherapy for patients with transurethral resection before implantation in prostate cancer: long-term results

    Energy Technology Data Exchange (ETDEWEB)

    Prada, Pedro J.; Anchuelo, Javier; Blanco, Ana Garcia; Paya, Gema; Cardenal, Juan; Acuña, Enrique; Ferri, Maria [Department of Radiation Oncology, Hospital Universitario Marqués de Valdecilla, Santander, Cantabria (Spain); Vazquez, Andres; Pacheco, Maite; Sanchez, Jesica [Department of Radiation Physics, Hospital Universitario Marqués de Valdecilla, Santander, Cantabria (Spain)

    2016-01-15

    Objectives: We analyzed the long-term oncologic outcome for patients with prostate cancer and transurethral resection who were treated using low-dose-rate (LDR) prostate brachytherapy. Methods and Materials: From January 2001 to December 2005, 57 consecutive patients were treated with clinically localized prostate cancer. No patients received external beam radiation. All of them underwent LDR prostate brachytherapy. Biochemical failure was defined according to the 'Phoenix consensus'. Patients were stratified as low and intermediate risk based on The Memorial Sloan Kettering group definition. Results: The median follow-up time for these 57 patients was 104 months. The overall survival according to Kaplan-Meier estimates was 88% (±6%) at 5 years and 77% (±6%) at 12 years. The 5 and 10 years for failure in tumour-free survival (TFS) was 96% and respectively (±2%), whereas for biochemical control was 94% and respectively (±3%) at 5 and 10 years, 98% (±1%) of patients being free of local recurrence. A patient reported incontinence after treatment (1.7%). The chronic genitourinary complains grade I were 7% and grade II, 10%. At six months 94% of patients reported no change in bowel function. Conclusions: The excellent long-term results and low morbidity presented, as well as the many advantages of prostate brachytherapy over other treatments, demonstrates that brachytherapy is an effective treatment for patients with transurethral resection and clinical organ-confined prostate cancer. (author)

  4. Music therapy for mood disturbance during hospitalization for autologous stem cell transplantation: a randomized controlled trial.

    Science.gov (United States)

    Cassileth, Barrie R; Vickers, Andrew J; Magill, Lucanne A

    2003-12-15

    High-dose therapy with autologous stem cell transplantation (HDT/ASCT) is a commonly used treatment for hematologic malignancies. The procedure causes significant psychological distress and no interventions have been demonstrated to improve mood in these patients. Music therapy has been shown to improve anxiety in a variety of acute medical settings. In the current study, the authors determined the effects of music therapy compared with standard care on mood during inpatient stays for HDT/ASCT. Patients with hematologic malignancy admitted for HDT/ASCT at two sites (Memorial Sloan-Kettering Cancer Center and Ireland Cancer Center in Cleveland, Ohio) were randomized to receive music therapy given by trained music therapists or standard care. Outcome was assessed at baseline and every 3 days after randomization using the Profile of Mood States. Of 69 patients registered in the study, follow-up data were available for 62 (90%). During their inpatient stay, patients in the music therapy group scored 28% lower on the combined Anxiety/Depression scale (P = 0.065) and 37% lower (P = 0.01) on the total mood disturbance score compared with controls. Music therapy is a noninvasive and inexpensive intervention that appears to reduce mood disturbance in patients undergoing HDT/ASCT. Copyright 2003 American Cancer Society.

  5. Hemithoracic radiation therapy after pleurectomy/decortication for malignant pleural mesothelioma

    International Nuclear Information System (INIS)

    Gupta, Vishal; Mychalczak, Borys; Krug, Lee; Flores, Raja; Bains, Manjit; Rusch, Valerie W.; Rosenzweig, Kenneth E.

    2005-01-01

    Purpose: To evaluate pleurectomy/decortication (P/D) and adjuvant radiotherapy (RT) in the treatment of malignant pleural mesothelioma (MPM). Methods and Materials: In a retrospective review, we included MPM patients treated with P/D and adjuvant RT at Memorial Sloan-Kettering Cancer Center from 1974 to 2003. When indicated, patients received intraoperative brachytherapy to residual tumor. Results: All 123 patients received external beam RT (median dose, 42.5 Gy; range, 7.2-67.8 Gy) to the ipsilateral hemithorax postoperatively. Fifty-four patients underwent brachytherapy (matched peripheral dose, 160 Gy). The median and 2-year overall survival for all patients was 13.5 months (range, 1-199 months) and 23%, respectively. One-year actuarial local control for all patients was 42%. Multivariate analysis for overall survival revealed radiation dose <40 Gy (p = 0.001), nonepithelioid histology (p = 0.002), left-sided disease (p = 0.01), and the use of an implant (p = 0.02) to be unfavorable. Two patients (1.6%) died from Grade 5 toxicity within 1 month of treatment. Conclusions: Pleurectomy/decortication with adjuvant radiotherapy is not an effective treatment option for patients with MPM. Our results imply that residual disease cannot be eradicated with external RT with or without brachytherapy and that a more extensive surgery followed by external RT might be required to improve local control and overall survival

  6. The roots of modern oncology: from discovery of new antitumor anthracyclines to their clinical use.

    Science.gov (United States)

    Cassinelli, Giuseppe

    2016-06-02

    In May 1960, the Farmitalia CEO Dr. Bertini and the director of the Istituto Nazionale dei Tumori of Milan Prof. Bucalossi (talent scout and city's Mayor) signed a research agreement for the discovery and development up to clinical trials of new natural antitumor agents. This agreement can be considered as a pioneering and fruitful example of a translational discovery program with relevant transatlantic connections. Owing to an eclectic Streptomyces, found near Castel del Monte (Apulia), and to the skilled and motivated participants of both institutions, a new natural antitumor drug, daunomycin, was ready for clinical trials within 3 years. Patent interference by the Farmitalia French partner was overcome by the good quality of the Italian drug and by the cooperation between Prof. Di Marco, director of the Istituto Ricerche Farmitalia Research Laboratories for Microbiology and Chemotherapy, and Prof. Karnofsky, head of the Sloan-Kettering Cancer Institute of New York, leading to the first transatlantic clinical trials. The search for daunomycin's sister anthracyclines led to the discovery and development of adriamycin, one of the best drugs born in Milan. This was the second act prologue of the history of Italian antitumor discovery and clinical oncology, which started in July 1969 when Prof. Di Marco sent Prof. Bonadonna the first vials of adriamycin (doxorubicin) to be tested in clinical trials. This article reviews the Milan scene in the 1960s, a city admired and noted for the outstanding scientific achievements of its private and public institutions in drugs and industrial product discovery.

  7. Multi-channel recording of a pulse spectrum on the screen of a Williams tube used with a ferrite memory analyser; Enregistrement du spectre d'impulsion sur l'ecran d'un tube de Williams au moyen d'un analyseur multicanal a memoire en ferrite; Zapis' spektra impul'sov na ehkrane ehlektronno-luchevoj trubki mnogokanal'nogo analizatora s ferritovoj pamyat'yu; Registro multicanal del espectro de los impulsos en la pantalla del tubo electronico, en un analizador con memoria de ferrita

    Energy Technology Data Exchange (ETDEWEB)

    Rumler, Shtirad [Institut Yadernogo Issledovannya Chekhoslovatskoj Akldemii Nauk, Rzhezh Chekhoslovatskaya Sotsialisticheskaya Respublika (Czech Republic)

    1962-04-15

    The paper describes a block-diagram of programme circuits with which it is possible to obtain a multi-channel trace of an expanded pulse-spectrum analysis on the screen of a Williams tube used in combination with a static ferrite memory. The conventional methods of direct recording on a Williams tube are in some cases unsatisfactory with the type of analyser in question, the trace being insufficiently clear, especially for the analysis of intermittent pulse cascades with a low-repetition frequency and a small average number of pulses. This is because the information to be read is interpreted in the channel straight from the adding circuits and address circuits with direct recording on the screen. The direct recording is unsuitable owing to the small average number of pulses and the statistically intermittent distribution. In this regard, the method proposed is better. The quality of the recording depends neither on the shape of the spectrum nor on the pulse-counting rate. This method is used in a 256-channel analyser with a ferrite memory of dead-time 15 {mu}s. An oscillographic trace, with a period equal to that of the spectrum analysis cycle, is produced periodically at a frequency of 50 cycles per second. The period of the trace cycle is approximately 4 ms, i.e. 20% of the total duration of the working-cycle of the analyser. In the case of analysers with a smaller number of channels and with a memory of shorter dead-time, the time for the oscillographic recording is only a few percent of the duration of the working-cycle of the analyser. (author) [French] L'auteur decrit un bloc-diagrammes des circuits de programmation qui, associes a une memoire statique en ferrite, permettent l'enregistrement multicanal, sur l'ecran d'un tube a rayons cathodiques, du spectre forme par les impulsions a analyser. Il est apparu que dans certains cas, les procedes habituels d'enregistrement, direct sur un tube de ce genre sont imparfaits lorsqu'on utilise un selecteur du modele

  8. ECT and memory loss.

    Science.gov (United States)

    Squire, L R

    1977-09-01

    The author reviews several studies that clarify the nature of the memory loss associated with ECT. Bilateral ECT produced greater anterograde memory loss than right unilateral ECT and more extensive retrograde amnesia than unilateral ECT. Reactivating memories just before ECT did not produce amnesia. Capacity for new learning recovered substantially by several months after ECT, but memory complaints were common in individuals who had received bilateral ECT. Other things being equal, right unilateral ECT seems preferable to bilateral ECT because the risks to memory associated with unilateral ECT are smaller.

  9. Determination of memory performance

    International Nuclear Information System (INIS)

    Gopych, P.M.

    1999-01-01

    Within the scope of testing statistical hypotheses theory a model definition and a computer method for model calculation of widely used in neuropsychology human memory performance (free recall, cued recall, and recognition probabilities), a model definition and a computer method for model calculation of intensities of cues used in experiments for testing human memory quality are proposed. Models for active and passive traces of memory and their relations are found. It was shown that autoassociative memory unit in the form of short two-layer artificial neural network with (or without) damages can be used for model description of memory performance in subjects with (or without) local brain lesions

  10. Quantum random access memory

    OpenAIRE

    Giovannetti, Vittorio; Lloyd, Seth; Maccone, Lorenzo

    2007-01-01

    A random access memory (RAM) uses n bits to randomly address N=2^n distinct memory cells. A quantum random access memory (qRAM) uses n qubits to address any quantum superposition of N memory cells. We present an architecture that exponentially reduces the requirements for a memory call: O(log N) switches need be thrown instead of the N used in conventional (classical or quantum) RAM designs. This yields a more robust qRAM algorithm, as it in general requires entanglement among exponentially l...

  11. Memory dynamics under stress.

    Science.gov (United States)

    Quaedflieg, Conny W E M; Schwabe, Lars

    2018-03-01

    Stressful events have a major impact on memory. They modulate memory formation in a time-dependent manner, closely linked to the temporal profile of action of major stress mediators, in particular catecholamines and glucocorticoids. Shortly after stressor onset, rapidly acting catecholamines and fast, non-genomic glucocorticoid actions direct cognitive resources to the processing and consolidation of the ongoing threat. In parallel, control of memory is biased towards rather rigid systems, promoting habitual forms of memory allowing efficient processing under stress, at the expense of "cognitive" systems supporting memory flexibility and specificity. In this review, we discuss the implications of this shift in the balance of multiple memory systems for the dynamics of the memory trace. Specifically, stress appears to hinder the incorporation of contextual details into the memory trace, to impede the integration of new information into existing knowledge structures, to impair the flexible generalisation across past experiences, and to hamper the modification of memories in light of new information. Delayed, genomic glucocorticoid actions might reverse the control of memory, thus restoring homeostasis and "cognitive" control of memory again.

  12. Detailed sensory memory, sloppy working memory

    Directory of Open Access Journals (Sweden)

    Ilja G Sligte

    2010-10-01

    Full Text Available Visual short-term memory (VSTM enables us to actively maintain information in mind for a brief period of time after stimulus disappearance. According to recent studies, VSTM consists of three stages - iconic memory, fragile VSTM, and visual working memory - with increasingly stricter capacity limits and progressively longer lifetimes. Still, the resolution (or amount of visual detail of each VSTM stage has remained unexplored and we test this in the present study. We presented people with a change detection task that measures the capacity of all three forms of VSTM, and we added an identification display after each change trial that required people to identify the pre-change object. Accurate change detection plus pre-change identification requires subjects to have a high-resolution representation of the pre-change object, whereas change detection or identification only can be based on the hunch that something has changed, without exactly knowing what was presented before. We observed that people maintained 6.1 objects in iconic memory, 4.6 objects in fragile VSTM and 2.1 objects in visual working memory. Moreover, when people detected the change, they could also identify the pre-change object on 88 percent of the iconic memory trials, on 71 percent of the fragile VSTM trials and merely on 53 percent of the visual working memory trials. This suggests that people maintain many high-resolution representations in iconic memory and fragile VSTM, but only one high-resolution object representation in visual working memory.

  13. NAND flash memory technologies

    CERN Document Server

    Aritome, Seiichi

    2016-01-01

    This book discusses basic and advanced NAND flash memory technologies, including the principle of NAND flash, memory cell technologies, multi-bits cell technologies, scaling challenges of memory cell, reliability, and 3-dimensional cell as the future technology. Chapter 1 describes the background and early history of NAND flash. The basic device structures and operations are described in Chapter 2. Next, the author discusses the memory cell technologies focused on scaling in Chapter 3, and introduces the advanced operations for multi-level cells in Chapter 4. The physical limitations for scaling are examined in Chapter 5, and Chapter 6 describes the reliability of NAND flash memory. Chapter 7 examines 3-dimensional (3D) NAND flash memory cells and discusses the pros and cons in structure, process, operations, scalability, and performance. In Chapter 8, challenges of 3D NAND flash memory are dis ussed. Finally, in Chapter 9, the author summarizes and describes the prospect of technologies and market for the fu...

  14. Stochastic memory: Memory enhancement due to noise

    Science.gov (United States)

    Stotland, Alexander; di Ventra, Massimiliano

    2012-01-01

    There are certain classes of resistors, capacitors, and inductors that, when subject to a periodic input of appropriate frequency, develop hysteresis loops in their characteristic response. Here we show that the hysteresis of such memory elements can also be induced by white noise of appropriate intensity even at very low frequencies of the external driving field. We illustrate this phenomenon using a physical model of memory resistor realized by TiO2 thin films sandwiched between metallic electrodes and discuss under which conditions this effect can be observed experimentally. We also discuss its implications on existing memory systems described in the literature and the role of colored noise.

  15. The contributions of handedness and working memory to episodic memory.

    Science.gov (United States)

    Sahu, Aparna; Christman, Stephen D; Propper, Ruth E

    2016-11-01

    Past studies have independently shown associations of working memory and degree of handedness with episodic memory retrieval. The current study takes a step ahead by examining whether handedness and working memory independently predict episodic memory. In agreement with past studies, there was an inconsistent-handed advantage for episodic memory; however, this advantage was absent for working memory tasks. Furthermore, regression analyses showed handedness, and complex working memory predicted episodic memory performance at different times. Results are discussed in light of theories of episodic memory and hemispheric interaction.

  16. Memory for speech and speech for memory.

    Science.gov (United States)

    Locke, J L; Kutz, K J

    1975-03-01

    Thirty kindergarteners, 15 who substituted /w/ for /r/ and 15 with correct articulation, received two perception tests and a memory test that included /w/ and /r/ in minimally contrastive syllables. Although both groups had nearly perfect perception of the experimenter's productions of /w/ and /r/, misarticulating subjects perceived their own tape-recorded w/r productions as /w/. In the memory task these same misarticulating subjects committed significantly more /w/-/r/ confusions in unspoken recall. The discussion considers why people subvocally rehearse; a developmental period in which children do not rehearse; ways subvocalization may aid recall, including motor and acoustic encoding; an echoic store that provides additional recall support if subjects rehearse vocally, and perception of self- and other- produced phonemes by misarticulating children-including its relevance to a motor theory of perception. Evidence is presented that speech for memory can be sufficiently impaired to cause memory disorder. Conceptions that restrict speech disorder to an impairment of communication are challenged.

  17. Psychophysiology of prospective memory.

    Science.gov (United States)

    Rothen, Nicolas; Meier, Beat

    2014-01-01

    Prospective memory involves the self-initiated retrieval of an intention upon an appropriate retrieval cue. Cue identification can be considered as an orienting reaction and may thus trigger a psychophysiological response. Here we present two experiments in which skin conductance responses (SCRs) elicited by prospective memory cues were compared to SCRs elicited by aversive stimuli to test whether a single prospective memory cue triggers a similar SCR as an aversive stimulus. In Experiment 2 we also assessed whether cue specificity had a differential influence on prospective memory performance and on SCRs. We found that detecting a single prospective memory cue is as likely to elicit a SCR as an aversive stimulus. Missed prospective memory cues also elicited SCRs. On a behavioural level, specific intentions led to better prospective memory performance. However, on a psychophysiological level specificity had no influence. More generally, the results indicate reliable SCRs for prospective memory cues and point to psychophysiological measures as valuable approach, which offers a new way to study one-off prospective memory tasks. Moreover, the findings are consistent with a theory that posits multiple prospective memory retrieval stages.

  18. Acerca del moho

    Science.gov (United States)

    El moho forma parte del medio ambiente natural. Afuera del hogar, el moho juega un papel en la naturaleza al desintegrar materias organicas tales como las hojas que se han caido o los arboles muertos. El moho puede crecer adentro del hogar cuando las espor

  19. Del bit al qubit

    OpenAIRE

    Torras Font, Josep

    2011-01-01

    Aquest document pretén donar una visió del desenvolupament dels computadors electrònics i dels components que els han fet possibles. Dintre de les opcions de futur en computació, també intenta donar una visió de les bases en que es fonamenta la computació quàntica.

  20. Intentionally fabricated autobiographical memories.

    Science.gov (United States)

    Justice, Lucy V; Morrison, Catriona M; Conway, Martin A

    2018-02-01

    Participants generated both autobiographical memories (AMs) that they believed to be true and intentionally fabricated autobiographical memories (IFAMs). Memories were constructed while a concurrent memory load (random 8-digit sequence) was held in mind or while there was no concurrent load. Amount and accuracy of recall of the concurrent memory load was reliably poorer following generation of IFAMs than following generation of AMs. There was no reliable effect of load on memory generation times; however, IFAMs always took longer to construct than AMs. Finally, replicating previous findings, fewer IFAMs had a field perspective than AMs, IFAMs were less vivid than AMs, and IFAMs contained more motion words (indicative of increased cognitive load). Taken together, these findings show a pattern of systematic differences that mark out IFAMs, and they also show that IFAMs can be identified indirectly by lowered performance on concurrent tasks that increase cognitive load.

  1. Shape memory polymers

    Energy Technology Data Exchange (ETDEWEB)

    Wilson, Thomas S.; Bearinger, Jane P.

    2017-08-29

    New shape memory polymer compositions, methods for synthesizing new shape memory polymers, and apparatus comprising an actuator and a shape memory polymer wherein the shape memory polymer comprises at least a portion of the actuator. A shape memory polymer comprising a polymer composition which physically forms a network structure wherein the polymer composition has shape-memory behavior and can be formed into a permanent primary shape, re-formed into a stable secondary shape, and controllably actuated to recover the permanent primary shape. Polymers have optimal aliphatic network structures due to minimization of dangling chains by using monomers that are symmetrical and that have matching amine and hydroxl groups providing polymers and polymer foams with clarity, tight (narrow temperature range) single transitions, and high shape recovery and recovery force that are especially useful for implanting in the human body.

  2. Time for memory

    DEFF Research Database (Denmark)

    Murakami, Kyoko

    2012-01-01

    This article is a continuous dialogue on memory triggered by Brockmeier’s (2010) article. I drift away from the conventionalization of the archive as a spatial metaphor for memory in order to consider the greater possibility of “time” for conceptualizing memory. The concept of time is central...... in terms of autobiographical memory. The second category of time is discussed, drawing on Augustine and Bergson amongst others. Bergson’s notion of duration has been considered as a promising concept for a better understanding of autobiographical memory. Psychological phenomena such as autobiographical...... memory should embrace not only spatial dimension, but also a temporal dimension, in which a constant flow of irreversible time, where multiplicity, momentarily, dynamic stability and becoming and emergence of novelty can be observed....

  3. Shape memory polymers

    Science.gov (United States)

    Wilson, Thomas S.; Bearinger, Jane P.

    2015-06-09

    New shape memory polymer compositions, methods for synthesizing new shape memory polymers, and apparatus comprising an actuator and a shape memory polymer wherein the shape memory polymer comprises at least a portion of the actuator. A shape memory polymer comprising a polymer composition which physically forms a network structure wherein the polymer composition has shape-memory behavior and can be formed into a permanent primary shape, re-formed into a stable secondary shape, and controllably actuated to recover the permanent primary shape. Polymers have optimal aliphatic network structures due to minimization of dangling chains by using monomers that are symmetrical and that have matching amine and hydroxyl groups providing polymers and polymer foams with clarity, tight (narrow temperature range) single transitions, and high shape recovery and recovery force that are especially useful for implanting in the human body.

  4. Zone memories and pseudorandom addressing

    International Nuclear Information System (INIS)

    Marino, D.; Mirizzi, N.; Stella, R.; Visaggio, G.

    1975-01-01

    A quantitative comparison between zone memories, pseudorandom addressed memories and an alternative special purpose memory (spread zone memory) in which the distance between any two transformed descriptors, at first adjacent, is independent of the descriptors pair and results the maximum one is presented. This memory has not been particularly considered at present in spite of its efficiency and its simple implementation

  5. Memória Organizacional e Reutilização do Conhecimento Técnico em uma Empresa do Setor Eletroeletrônico no BrasilOrganizational Memory and the Reutilization of the Technical Knowledge in an Electro-electronic Segment Company in BrazilMemoria Organizacional y Reutilización de Conocimiento Técnico en una Empresa del Sector Electroelectrónico en Brasil

    Directory of Open Access Journals (Sweden)

    SPILLER, Arnaldo

    2007-12-01

    included in the study. The employees were surveyed by means of a Likert-scale questionnaire for the quantitative analysis where the factorial analysis was applied. The overall results indicated that although the employees recognize the importance to grow the explicit technological organizational memory, and valorize the memory processes, such processes do not occur in an effective way in the company. Furthermore, the respondents indicated the availability of enough collective information for them to solve their technical problems.RESUMENEste artículo tiene como objetivo presentar los resultados de un trabajo de pesquisa que investigó, al través del método de estudio de caso, aplicado en una empresa multinacional del Sector Electro-electrónico en Brasil, la existencia de practicas que están direccionadas a la formación de una memoria organizacional explícita para la preservación del conocimiento técnico, bien como la ocurrencia de practicas de reutilización de este conocimiento en la resolución de problemas técnicos. Memoria Organizacional es la capacidad de la organización beneficiarse de las experiencias pasadas para contestar de forma más eficaz en el presente, caracterizada por la incorporación del conocimiento individual por la organización. La empresa-caso fue pesquisada en sus unidades brasileñas. Fue utilizado un cuestionario con escala Likert, y las respuestas fueron analizadas al través del método de análisis factorial. La pesquisa reveló que, aunque procesos de memoria organizacional no ocurran de forma efectiva, y a pesar de las opiniones bastante divididas, existe, sí, alguna preocupación con relación a la memoria organizacional tecnológica explícita y con relación a la reutilización del conocimiento. Además, los sujetos de la pesquisa indicaron que hay disponibilidad suficiente de informaciones del uso colectivo para resolvieren sus problemas técnicos.

  6. Music, memory and emotion

    OpenAIRE

    J?ncke, Lutz

    2008-01-01

    Because emotions enhance memory processes and music evokes strong emotions, music could be involved in forming memories, either about pieces of music or about episodes and information associated with particular music. A recent study in BMC Neuroscience has given new insights into the role of emotion in musical memory. Music has a prominent role in the everyday life of many people. Whether it is for recreation, distraction or mood enhancement, a lot of people listen to music from early in t...

  7. Making Memories Matter

    OpenAIRE

    Gold, Paul E.; Korol, Donna L.

    2012-01-01

    This article reviews some of the neuroendocrine bases by which emotional events regulate brain mechanisms of learning and memory. In laboratory rodents, there is extensive evidence that epinephrine influences memory processing through an inverted-U relationship, at which moderate levels enhance and high levels impair memory. These effects are, in large part, mediated by increases in blood glucose levels subsequent to epinephrine release, which then provide support for the brain processes en...

  8. Emotion and Autobiographical Memory

    Directory of Open Access Journals (Sweden)

    Nuray Sarp

    2011-09-01

    Full Text Available Self and mind are constituted with the cumulative effects of significant life events. This description is regarded as a given explicitly or implicitly in vari-ous theories of personality. Such an acknowledgment inevitably brings together these theories on two basic concepts. The first one is the emotions that give meaning to experiences and the second one is the memory which is related to the storage of these experiences. The part of the memory which is responsible for the storage and retrieval of life events is the autobiographical memory. Besides the development of personality, emotions and autobiographical memory are important in the development of and maintenance of psychopathology. Therefore, these two concepts have both longitudinal and cross-sectional functions in understanding human beings. In case of psychopathology, understanding emotions and autobiographical memory developmentally, aids in understanding the internal susceptibility factors. In addition, understanding how these two structures work and influence each other in an acute event would help to understand the etiological mechanisms of mental disorders. In the literature, theories that include both of these structures and that have clinical implications, are inconclusive. Theories on memory generally focus on cognitive and semantic structures while neglecting emotions, whereas theories on emotions generally neglect memory and its organization. There are only a few theories that cover both of these two concepts. In the present article, these theories that include both emotions and autobiographical memory in the same framework (i.e. Self Memory System, Associative Network Theory, Structural and Contextual theories and Affect Regulation Theory were discussed to see the full picture. Taken together, these theories seem to have the potential to suggest data-driven models in understanding and explaining symptoms such as flashbacks, dissociation, amnesia, over general memory seen in

  9. Islamic Myths and Memories

    DEFF Research Database (Denmark)

    Islamic myths and collective memory are very much alive in today’s localized struggles for identity, and are deployed in the ongoing construction of worldwide cultural networks. This book brings the theoretical perspectives of myth-making and collective memory to the study of Islam and globalizat....... It shows how contemporary Islamic thinkers and movements respond to the challenges of globalization by preserving, reviving, reshaping, or transforming myths and memories....

  10. Memory T Cell Migration

    OpenAIRE

    Qianqian eZhang; Qianqian eZhang; Fadi G. Lakkis

    2015-01-01

    Immunological memory is a key feature of adaptive immunity. It provides the organism with long-lived and robust protection against infection. In organ transplantation, memory T cells pose a significant threat by causing allograft rejection that is generally resistant to immunosuppressive therapy. Therefore, a more thorough understanding of memory T cell biology is needed to improve the survival of transplanted organs without compromising the host’s ability to fight infections. This review...

  11. Iconic memory requires attention

    OpenAIRE

    Persuh, Marjan; Genzer, Boris; Melara, Robert D.

    2012-01-01

    Two experiments investigated whether attention plays a role in iconic memory, employing either a change detection paradigm (Experiment 1) or a partial-report paradigm (Experiment 2). In each experiment, attention was taxed during initial display presentation, focusing the manipulation on consolidation of information into iconic memory, prior to transfer into working memory. Observers were able to maintain high levels of performance (accuracy of change detection or categorization) even when co...

  12. Phase change memory

    CERN Document Server

    Qureshi, Moinuddin K

    2011-01-01

    As conventional memory technologies such as DRAM and Flash run into scaling challenges, architects and system designers are forced to look at alternative technologies for building future computer systems. This synthesis lecture begins by listing the requirements for a next generation memory technology and briefly surveys the landscape of novel non-volatile memories. Among these, Phase Change Memory (PCM) is emerging as a leading contender, and the authors discuss the material, device, and circuit advances underlying this exciting technology. The lecture then describes architectural solutions t

  13. Memories Persist in Silence

    Directory of Open Access Journals (Sweden)

    Sandra Patricia Arenas Grisales

    2012-08-01

    Full Text Available This article exposes the hypothesis that memory artifacts, created to commemorate the victims of armed conflict in Colombia, are an expression of the underground memories and a way of political action in the midst of war. We analyze three cases of creations of memory artifacts in Medellín, Colombia, as forms of suffering, perceiving and resisting the power of armed groups in Medellín. The silence, inherent in these objects, should not be treated as an absence of language, but as another form of expression of memory. Silence is a tactic used to overcome losses and reset everyday life in contexts of protracted violence.

  14. The future of memory

    Science.gov (United States)

    Marinella, M.

    In the not too distant future, the traditional memory and storage hierarchy of may be replaced by a single Storage Class Memory (SCM) device integrated on or near the logic processor. Traditional magnetic hard drives, NAND flash, DRAM, and higher level caches (L2 and up) will be replaced with a single high performance memory device. The Storage Class Memory paradigm will require high speed (read/write), excellent endurance (> 1012), nonvolatility (retention > 10 years), and low switching energies (memory (PCM). All of these devices show potential well beyond that of current flash technologies and research efforts are underway to improve the endurance, write speeds, and scalabilities to be on-par with DRAM. This progress has interesting implications for space electronics: each of these emerging device technologies show excellent resistance to the types of radiation typically found in space applications. Commercially developed, high density storage class memory-based systems may include a memory that is physically radiation hard, and suitable for space applications without major shielding efforts. This paper reviews the Storage Class Memory concept, emerging memory devices, and possible applicability to radiation hardened electronics for space.

  15. Sparse distributed memory overview

    Science.gov (United States)

    Raugh, Mike

    1990-01-01

    The Sparse Distributed Memory (SDM) project is investigating the theory and applications of massively parallel computing architecture, called sparse distributed memory, that will support the storage and retrieval of sensory and motor patterns characteristic of autonomous systems. The immediate objectives of the project are centered in studies of the memory itself and in the use of the memory to solve problems in speech, vision, and robotics. Investigation of methods for encoding sensory data is an important part of the research. Examples of NASA missions that may benefit from this work are Space Station, planetary rovers, and solar exploration. Sparse distributed memory offers promising technology for systems that must learn through experience and be capable of adapting to new circumstances, and for operating any large complex system requiring automatic monitoring and control. Sparse distributed memory is a massively parallel architecture motivated by efforts to understand how the human brain works. Sparse distributed memory is an associative memory, able to retrieve information from cues that only partially match patterns stored in the memory. It is able to store long temporal sequences derived from the behavior of a complex system, such as progressive records of the system's sensory data and correlated records of the system's motor controls.

  16. Models of Working Memory

    National Research Council Canada - National Science Library

    Miyake, Akira

    1997-01-01

    .... Understanding the mechanisms and structures underlying working memory is, hence, one of the most important scientific issues that need to be addressed to improve the efficiency and performance...

  17. Single-item memory, associative memory, and the human hippocampus

    OpenAIRE

    Gold, Jeffrey J.; Hopkins, Ramona O.; Squire, Larry R.

    2006-01-01

    We tested recognition memory for items and associations in memory-impaired patients with bilateral lesions thought to be limited to the hippocampal region. In Experiment 1 (Combined memory test), participants studied words and then took a memory test in which studied words, new words, studied word pairs, and recombined word pairs were presented in a mixed order. In Experiment 2 (Separated memory test), participants studied single words and then took a memory test involving studied word and ne...

  18. Memory reconsolidation mediates the updating of hippocampal memory content

    OpenAIRE

    Jonathan L C Lee

    2010-01-01

    The retrieval or reactivation of a memory places it into a labile state, requiring a process of reconsolidation to restabilize it. This retrieval-induced plasticity is a potential mechanism for the modification of the existing memory. Following previous data supportive of a functional role for memory reconsolidation in the modification of memory strength, here I show that hippocampal memory reconsolidation also supports the updating of contextual memory content. Using a procedure that se...

  19. A real-time multichannel memory controller and optimal mapping of memory clients to memory channels

    NARCIS (Netherlands)

    Gomony, M.D.; Akesson, K.B.; Goossens, K.G.W.

    2015-01-01

    Ever-increasing demands for main memory bandwidth and memory speed/power tradeoff led to the introduction of memories with multiple memory channels, such as Wide IO DRAM. Efficient utilization of a multichannel memory as a shared resource in multiprocessor real-time systems depends on mapping of the

  20. Acoustic Masking in Primary Memory

    Science.gov (United States)

    Colle, Herbert A.; Welsh, Alan

    1976-01-01

    Two experiments are reported to investigate the theory that since auditory sensory memory is used to store memory information, concurrent auditory stimulation should destroy memory information and thus reduce recall performance. (Author/RM)

  1. Applications for Packetized Memory Interfaces

    OpenAIRE

    Watson, Myles Glen

    2015-01-01

    The performance of the memory subsystem has a large impact on the performance of modern computer systems. Many important applications are memory bound and others are expected to become memory bound in the future. The importance of memory performance makes it imperative to understand and optimize the interactions between applications and the system architecture. Prototyping and exploring various configurations of memory systems can give important insights, but current memory interfaces are lim...

  2. Time Series with Long Memory

    OpenAIRE

    西埜, 晴久

    2004-01-01

    The paper investigates an application of long-memory processes to economic time series. We show properties of long-memory processes, which are motivated to model a long-memory phenomenon in economic time series. An FARIMA model is described as an example of long-memory model in statistical terms. The paper explains basic limit theorems and estimation methods for long-memory processes in order to apply long-memory models to economic time series.

  3. Algunas aclaraciones acerca del conocimiento del singular.

    Directory of Open Access Journals (Sweden)

    Carlos Llano Cifuentes

    2013-11-01

    Full Text Available Llano tries to explain the main purpose of El Conocimiento del Singular, showing how the individuals about which the book is concerned are basically human individuals: people as decision makers.

  4. Manifiesto de los agravios, bexaciones, y molestias, Que padecen los indios del reyno del Peru

    Directory of Open Access Journals (Sweden)

    Vicente Morachimo

    2011-05-01

    Full Text Available Este texto es un memorial presentado en 1732 al Rey de España por Vicente Morachimoo Vicente Mora Chimo Cápac, noble indígena descendiente de los antiguos señores delreino Chimú, procurador y diputado general de los indios del Perú en la corte española.Este importante texto forma parte de la amplia producción discursiva promovida sobretodo en el siglo XVIII por las noblezas indígenas del Perú colonial, expresión delfenómeno conocido como movimiento inca o renacimiento inca. Esa produccióndiscursiva es estudiada en el libro de Carlos García-Bedoya La literatura peruana en elperiodo de estabilización colonial (Lima: Fondo Editorial de la UNMSM, 2000.Tomamos el texto de un microfilm sacado de un ejemplar del texto conservado en laBiblioteca Nacional de Santiago de Chile, que por cierto debió pertenecer a nuestraantigua Biblioteca Nacional hasta los años de la Guerra del Pacífico. Se ha respetado lapuntuación y la ortografía del original, salvo la sustitución de la antigua S larga pornuestra s normal.

  5. Memory systems interaction in the pigeon: working and reference memory.

    Science.gov (United States)

    Roberts, William A; Strang, Caroline; Macpherson, Krista

    2015-04-01

    Pigeons' performance on a working memory task, symbolic delayed matching-to-sample, was used to examine the interaction between working memory and reference memory. Reference memory was established by training pigeons to discriminate between the comparison cues used in delayed matching as S+ and S- stimuli. Delayed matching retention tests then measured accuracy when working and reference memory were congruent and incongruent. In 4 experiments, it was shown that the interaction between working and reference memory is reciprocal: Strengthening either type of memory leads to a decrease in the influence of the other type of memory. A process dissociation procedure analysis of the data from Experiment 4 showed independence of working and reference memory, and a model of working memory and reference memory interaction was shown to predict the findings reported in the 4 experiments. (PsycINFO Database Record (c) 2015 APA, all rights reserved).

  6. Human Learning and Memory

    Science.gov (United States)

    Lieberman, David A.

    2012-01-01

    This innovative textbook is the first to integrate learning and memory, behaviour, and cognition. It focuses on fascinating human research in both memory and learning (while also bringing in important animal studies) and brings the reader up to date with the latest developments in the subject. Students are encouraged to think critically: key…

  7. Memory and technology

    Directory of Open Access Journals (Sweden)

    Olimpia Niglio

    2017-12-01

    Full Text Available The concept of "memory" has different meanings when analyzed within specific cultural contexts. In general, the memory expresses the ability of man to keep track of events, information, sensations, ideas, experiences, and recall this consciousness as soon as certain motivations make necessary the contribution of past experience.

  8. Shape memory alloys

    International Nuclear Information System (INIS)

    Kaszuwara, W.

    2004-01-01

    Shape memory alloys (SMA), when deformed, have the ability of returning, in certain circumstances, to their initial shape. Deformations related to this phenomenon are for polycrystals 1-8% and up to 15% for monocrystals. The deformation energy is in the range of 10 6 - 10 7 J/m 3 . The deformation is caused by martensitic transformation in the material. Shape memory alloys exhibit one directional or two directional shape memory effect as well as pseudoelastic effect. Shape change is activated by temperature change, which limits working frequency of SMA to 10 2 Hz. Other group of alloys exhibit magnetic shape memory effect. In these alloys martensitic transformation is triggered by magnetic field, thus their working frequency can be higher. Composites containing shape memory alloys can also be used as shape memory materials (applied in vibration damping devices). Another group of composite materials is called heterostructures, in which SMA alloys are incorporated in a form of thin layers The heterostructures can be used as microactuators in microelectromechanical systems (MEMS). Basic SMA comprise: Ni-Ti, Cu (Cu-Zn,Cu-Al, Cu-Sn) and Fe (Fe-Mn, Fe-Cr-Ni) alloys. Shape memory alloys find applications in such areas: automatics, safety and medical devices and many domestic appliances. Currently the most important appears to be research on magnetic shape memory materials and high temperature SMA. Vital from application point of view are composite materials especially those containing several intelligent materials. (author)

  9. Human memory search

    NARCIS (Netherlands)

    Davelaar, E.J.; Raaijmakers, J.G.W.; Hills, T.T.; Robbins, T.W.; Todd, P.M.

    2012-01-01

    The importance of understanding human memory search is hard to exaggerate: we build and live our lives based on what whe remember. This chapter explores the characteristics of memory search, with special emphasis on the use of retrieval cues. We introduce the dependent measures that are obtained

  10. Static memory devices

    NARCIS (Netherlands)

    2012-01-01

    A semiconductor memory device includes n-wells (22) and p-wells (24) used to make up a plurality of memory cell elements (40). The n-wells (22) and p-5 wells (24) can be back-biased to improve reading and writing performance. One of the n-wells and p-wells can be globally biased while the other one

  11. Human Memory: The Basics

    Science.gov (United States)

    Martinez, Michael E.

    2010-01-01

    The human mind has two types of memory: short-term and long-term. In all types of learning, it is best to use that structure rather than to fight against it. One way to do that is to ensure that learners can fit new information into patterns that can be stored in and more easily retrieved from long-term memory.

  12. Working Memory and Attitudes

    Science.gov (United States)

    Jung, Eun Sook; Reid, Norman

    2009-01-01

    Working memory capacity has been shown to be an important factor in controlling understanding in the sciences. Attitudes related to studies in the sciences are also known to be important in relation to success in learning. It might be argued that if working memory capacity is a rate controlling feature of learning and success in understanding…

  13. Reading and Working Memory

    Science.gov (United States)

    Baddeley, Alan

    1984-01-01

    Outlines the concept of working memory, with particular reference to a hypothetical subcomponent, the articulatory loop. Discusses the role of the loop in fluent adult reading, then examines the reading performance of adults with deficits in auditory verbal memory, showing that a capacity to articulate is not necessary for the effective…

  14. The memory of volatility

    Directory of Open Access Journals (Sweden)

    Kai R. Wenger

    2018-03-01

    Full Text Available The focus of the volatility literature on forecasting and the predominance of theconceptually simpler HAR model over long memory stochastic volatility models has led to the factthat the actual degree of memory estimates has rarely been considered. Estimates in the literaturerange roughly between 0.4 and 0.6 - that is from the higher stationary to the lower non-stationaryregion. This difference, however, has important practical implications - such as the existence or nonexistenceof the fourth moment of the return distribution. Inference on the memory order is complicatedby the presence of measurement error in realized volatility and the potential of spurious long memory.In this paper we provide a comprehensive analysis of the memory in variances of international stockindices and exchange rates. On the one hand, we find that the variance of exchange rates is subject tospurious long memory and the true memory parameter is in the higher stationary range. Stock indexvariances, on the other hand, are free of low frequency contaminations and the memory is in the lowernon-stationary range. These results are obtained using state of the art local Whittle methods that allowconsistent estimation in presence of perturbations or low frequency contaminations.

  15. Predicting Reasoning from Memory

    Science.gov (United States)

    Heit, Evan; Hayes, Brett K.

    2011-01-01

    In an effort to assess the relations between reasoning and memory, in 8 experiments, the authors examined how well responses on an inductive reasoning task are predicted from responses on a recognition memory task for the same picture stimuli. Across several experimental manipulations, such as varying study time, presentation frequency, and the…

  16. An Exceptional Memory

    Science.gov (United States)

    Hunter, Ian M. L.

    1977-01-01

    An account is given of the exceptional memory of the late Professor A. C. Aitken who was also a distinguished mathematician and mental calculator. Compared with Shereshevskii, another man with exceptional memory, he shows the scholar's reliance on conceptual mapping rather than the mnemonist's reliance on perceptual chaining. (Editor)

  17. Eavesdropping without quantum memory

    International Nuclear Information System (INIS)

    Bechmann-Pasquinucci, H.

    2006-01-01

    In quantum cryptography the optimal eavesdropping strategy requires that the eavesdropper uses ancillas and quantum memories in order to optimize her information. What happens if the eavesdropper has no quantum memory? It is shown that in this case the eavesdropper obtains a better information/disturbance trade-off by adopting the simple intercept/resend strategy

  18. Search of associative memory.

    NARCIS (Netherlands)

    Raaijmakers, J.G.W.; Shiffrin, R.M.

    1981-01-01

    Describes search of associative memory (SAM), a general theory of retrieval from long-term memory that combines features of associative network models and random search models. It posits cue-dependent probabilistic sampling and recovery from an associative network, but the network is specified as a

  19. The Use of Memory.

    Science.gov (United States)

    Smith, R. D.

    1983-01-01

    The predominantly linguistic orientation to current educational thinking, with its emphasis on the abstract and indirect, does not solve the problem of achieving a sense of identity. Experiential memory is crucial in personal identity. The definition and use of experiential memory and its merit are explored. (SR)

  20. Schemas and memory consolidation.

    Science.gov (United States)

    Tse, Dorothy; Langston, Rosamund F; Kakeyama, Masaki; Bethus, Ingrid; Spooner, Patrick A; Wood, Emma R; Witter, Menno P; Morris, Richard G M

    2007-04-06

    Memory encoding occurs rapidly, but the consolidation of memory in the neocortex has long been held to be a more gradual process. We now report, however, that systems consolidation can occur extremely quickly if an associative "schema" into which new information is incorporated has previously been created. In experiments using a hippocampal-dependent paired-associate task for rats, the memory of flavor-place associations became persistent over time as a putative neocortical schema gradually developed. New traces, trained for only one trial, then became assimilated and rapidly hippocampal-independent. Schemas also played a causal role in the creation of lasting associative memory representations during one-trial learning. The concept of neocortical schemas may unite psychological accounts of knowledge structures with neurobiological theories of systems memory consolidation.

  1. Conflict and memory

    DEFF Research Database (Denmark)

    Wagoner, Brady; Brescó, Ignacio

    2016-01-01

    This introduction to the special issue on conflict and memory aims to underscore the importance of memory (whether individual and collective) in relation to intergroup conflicts. We argue that the way in which societies reconstruct and bring the past into the present—especially, the historical past......—is crucial when it comes to the study of intergroup conflict dynamics. In this regard, we also highlight the growing importance of memory studies within the area of social sciences as well as the multiple ways of approaching memory. Drawing from this wide theoretical framework, we introduce the articles...... of this issue, eight articles that tackle the role of memory in different conflicts, whether currently under way, in progress of being resolved, in postwar settings, or in contexts conflicts expected to happen do not arise....

  2. Children's episodic memory.

    Science.gov (United States)

    Ghetti, Simona; Lee, Joshua

    2011-07-01

    Episodic memory develops during childhood and adolescence. This trajectory depends on several underlying processes. In this article, we first discuss the development of the basic binding processes (e.g., the processes by which elements are bound together to form a memory episode) and control processes (e.g., reasoning and metamemory processes) involved in episodic remembering. Then, we discuss the role of these processes in false-memory formation. In the subsequent sections, we examine the neural substrates of the development of episodic memory. Finally, we discuss atypical development of episodic memory. As we proceed through the article, we suggest potential avenues for future research. WIREs Cogni Sci 2011 2 365-373 DOI: 10.1002/wcs.114 For further resources related to this article, please visit the WIREs website. Copyright © 2010 John Wiley & Sons, Ltd.

  3. Making memories matter

    Directory of Open Access Journals (Sweden)

    Paul E. Gold

    2012-12-01

    Full Text Available This article reviews some of the neuroendocrine bases by which emotional events regulate brain mechanisms of learning and memory. In laboratory rodents, there is extensive evidence that epinephrine influences memory processing through an inverted-U relationship, at which moderate levels enhance and high levels impair memory. These effects are, in large part, mediated by increases in blood glucose levels subsequent to epinephrine release, which then provide support for the brain processes engaged by learning and memory. These brain processes include augmentation of neurotransmitter release and of energy metabolism, the latter apparently including a key role for astrocytic glycogen. In addition to up- and down-regulation of learning and memory in general, physiological concomitants of emotion and arousal can also switch the neural system that controls learning at a particular time, at once improving some attributes of learning and impairing others in a manner that results in a change in the strategy used to solve a problem.

  4. Making Memories Matter

    Science.gov (United States)

    Gold, Paul E.; Korol, Donna L.

    2012-01-01

    This article reviews some of the neuroendocrine bases by which emotional events regulate brain mechanisms of learning and memory. In laboratory rodents, there is extensive evidence that epinephrine influences memory processing through an inverted-U relationship, at which moderate levels enhance and high levels impair memory. These effects are, in large part, mediated by increases in blood glucose levels subsequent to epinephrine release, which then provide support for the brain processes engaged by learning and memory. These brain processes include augmentation of neurotransmitter release and of energy metabolism, the latter apparently including a key role for astrocytic glycogen. In addition to up- and down-regulation of learning and memory in general, physiological concomitants of emotion and arousal can also switch the neural system that controls learning at a particular time, at once improving some attributes of learning and impairing others in a manner that results in a change in the strategy used to solve a problem. PMID:23264764

  5. Learning and memory.

    Science.gov (United States)

    Brem, Anna-Katharine; Ran, Kathy; Pascual-Leone, Alvaro

    2013-01-01

    Learning and memory functions are crucial in the interaction of an individual with the environment and involve the interplay of large, distributed brain networks. Recent advances in technologies to explore neurobiological correlates of neuropsychological paradigms have increased our knowledge about human learning and memory. In this chapter we first review and define memory and learning processes from a neuropsychological perspective. Then we provide some illustrations of how noninvasive brain stimulation can play a major role in the investigation of memory functions, as it can be used to identify cause-effect relationships and chronometric properties of neural processes underlying cognitive steps. In clinical medicine, transcranial magnetic stimulation may be used as a diagnostic tool to understand memory and learning deficits in various patient populations. Furthermore, noninvasive brain stimulation is also being applied to enhance cognitive functions, offering exciting translational therapeutic opportunities in neurology and psychiatry. © 2013 Elsevier B.V. All rights reserved.

  6. Optical quantum memory

    Science.gov (United States)

    Lvovsky, Alexander I.; Sanders, Barry C.; Tittel, Wolfgang

    2009-12-01

    Quantum memory is essential for the development of many devices in quantum information processing, including a synchronization tool that matches various processes within a quantum computer, an identity quantum gate that leaves any state unchanged, and a mechanism to convert heralded photons to on-demand photons. In addition to quantum computing, quantum memory will be instrumental for implementing long-distance quantum communication using quantum repeaters. The importance of this basic quantum gate is exemplified by the multitude of optical quantum memory mechanisms being studied, such as optical delay lines, cavities and electromagnetically induced transparency, as well as schemes that rely on photon echoes and the off-resonant Faraday interaction. Here, we report on state-of-the-art developments in the field of optical quantum memory, establish criteria for successful quantum memory and detail current performance levels.

  7. Emerging non-volatile memories

    CERN Document Server

    Hong, Seungbum; Wouters, Dirk

    2014-01-01

    This book is an introduction to the fundamentals of emerging non-volatile memories and provides an overview of future trends in the field. Readers will find coverage of seven important memory technologies, including Ferroelectric Random Access Memory (FeRAM), Ferromagnetic RAM (FMRAM), Multiferroic RAM (MFRAM), Phase-Change Memories (PCM), Oxide-based Resistive RAM (RRAM), Probe Storage, and Polymer Memories. Chapters are structured to reflect diffusions and clashes between different topics. Emerging Non-Volatile Memories is an ideal book for graduate students, faculty, and professionals working in the area of non-volatile memory. This book also: Covers key memory technologies, including Ferroelectric Random Access Memory (FeRAM), Ferromagnetic RAM (FMRAM), and Multiferroic RAM (MFRAM), among others. Provides an overview of non-volatile memory fundamentals. Broadens readers' understanding of future trends in non-volatile memories.

  8. Psicodrama del duelo.

    OpenAIRE

    José Antonio Espina Barrio; Marisol Filgueira Bouza

    1997-01-01

    La pérdida de rituales agrava y alarga la reacción del duelo. Se define el Psicodrama Antropológico y su intervención en el proceso del duelo. El Psicodrama Focal del Duelo es una psicoterapia breve centrada en el proceso de Duelo. Se comentan varios casos y resultados. Se concluye con un programa sencillo para el duelo en Atención Primaria.

  9. Memory and History of Mexico ’68

    Directory of Open Access Journals (Sweden)

    Eugenia Allier Montaño

    2016-10-01

    Full Text Available The student movement Mexico ’68 (Sesenta-y-ocho that was active between July and December of 1968 has come to be seen as one of the most important events of the second half of the twentieth century in Mexico, in both public memory and national history. However as this was not always the case, the aim of this article is to analyse the transformations and permanencies in the many accounts that have formed over the last four decades concerning the Mexican summer of 1968, giving attention to four types of narrative: public debates, the specialized historiography on the student movement, books dealing with national history, and the official history. This analysis is intended to show how the ‘historical centrality’ of 1968 was progressively formed in the national public space and in historiographic discourse. Resumen: Memorias e historias de México 68 El movimiento estudiantil de México 68 (Sesenta-y-ocho que tuvo lugar entre julio y diciembre de 1968 se considera como uno de los acontecimientos más importantes de México en la segunda mitad del siglo XX, tanto desde la memoria pública como desde la historiografía nacional. Sin embargo, como esto no siempre fue así, el objetivo del artículo es analizar las transformaciones y permanencias en las múltiples narraciones que se han creado a lo largo de las últimas cuatro décadas acerca del verano mexicano del 68, dando preeminencia a cuatro narrativas: los debates públicos, la historiografía especializada sobre el movimiento estudiantil, los libros abocados a la historia nacional y la historia oficial. Este análisis busca mostrar cómo se fue conformando la ‘centralidad histórica’ del 68 en el espacio público nacional y en los discursos historiográficos.

  10. Fractura triple del complejo suspensorio del hombro

    Directory of Open Access Journals (Sweden)

    Eraclio Delgado Rifá

    2015-06-01

    Full Text Available El complejo suspensorio del hombro es una estructura sumamente importante, compuesta por un anillo de huesos y tejidos blandos. Las lesiones aisladas de este complejo anatómico son frecuentes y no afectan su estabilidad. La interrupción doble conduce a la inestabilidad de esta estructura y usualmente requiere tratamiento quirúrgico. La triple interrupción, por su parte, es sumamente rara y es encontrada en casos de trauma de alta energía a menudo en asociación con otras lesiones. Se presenta una triple lesión del complejo suspensorio del hombro en un paciente de 46 años de edad, con una fractura de la glenoides, del acromion tipo III de Kuhn y de la coracoides tipo II de Ogawa. En este caso, la fractura del acromion fue tratada con fijación percutánea con alambres de Kirschner, por tener asociado lesiones de partes blandas que contraindicaron la reducción abierta. La fractura de la glenoides y de la apófisis coracoides fueron tratadas conservadoramente. Después de 6 meses de evolución, el paciente tuvo un resultado funcional aceptable, con una abducción de 90 grados, los 30 grados de rotación externa y 70 de rotación interna, además asintomático y consolidación de todas las fracturas. A pesar de ser catalogada de una lesión grave del cinturón escapular y estar asociada a otras lesiones se obtuvo un resultado satisfactorio al final del tratamiento.

  11. Aging Memories: Differential Decay of Episodic Memory Components

    Science.gov (United States)

    Talamini, Lucia M.; Gorree, Eva

    2012-01-01

    Some memories about events can persist for decades, even a lifetime. However, recent memories incorporate rich sensory information, including knowledge on the spatial and temporal ordering of event features, while old memories typically lack this "filmic" quality. We suggest that this apparent change in the nature of memories may reflect a…

  12. Associative working memory and subsequent episodic memory in Alzheimer's disease.

    NARCIS (Netherlands)

    Geldorp, B. van; Konings, E.P.; Tilborg, I.A. Van; Kessels, R.P.C.

    2012-01-01

    Recent studies indicate deficits in associative working memory in patients with medial-temporal lobe amnesia. However, it is unclear whether these deficits reflect working memory processing or are due to hippocampally mediated long-term memory impairment. We investigated associative working memory

  13. Associative working memory and subsequent episodic memory in Alzheimer's disease

    NARCIS (Netherlands)

    Geldorp, B. van; Konings, E.P.C.; Tilborg, I.A.D.A. van; Kessels, R.P.C.

    2012-01-01

    Recent studies indicate deficits in associative working memory in patients with medial-temporal lobe amnesia. However, it is unclear whether these deficits reflect working memory processing or are due to hippocampally mediated long-term memory impairment. We investigated associative working memory

  14. Aging memories: differential decay of episodic memory components.

    Science.gov (United States)

    Talamini, Lucia M; Gorree, Eva

    2012-05-17

    Some memories about events can persist for decades, even a lifetime. However, recent memories incorporate rich sensory information, including knowledge on the spatial and temporal ordering of event features, while old memories typically lack this "filmic" quality. We suggest that this apparent change in the nature of memories may reflect a preferential loss of hippocampus-dependent, configurational information over more cortically based memory components, including memory for individual objects. The current study systematically tests this hypothesis, using a new paradigm that allows the contemporaneous assessment of memory for objects, object pairings, and object-position conjunctions. Retention of each memory component was tested, at multiple intervals, up to 3 mo following encoding. The three memory subtasks adopted the same retrieval paradigm and were matched for initial difficulty. Results show differential decay of the tested episodic memory components, whereby memory for configurational aspects of a scene (objects' co-occurrence and object position) decays faster than memory for featured objects. Interestingly, memory requiring a visually detailed object representation decays at a similar rate as global object recognition, arguing against interpretations based on task difficulty and against the notion that (visual) detail is forgotten preferentially. These findings show that memories undergo qualitative changes as they age. More specifically, event memories become less configurational over time, preferentially losing some of the higher order associations that are dependent on the hippocampus for initial fast encoding. Implications for theories of long-term memory are discussed.

  15. Episodic Memory, Semantic Memory, and Fluency.

    Science.gov (United States)

    Schaefer, Carl F.

    1980-01-01

    Suggests that creating a second-language semantic network can be conceived as developing a plan for retrieving second-language word forms. Characteristics of linguistic performance which will promote fluency are discussed in light of the distinction between episodic and semantic memory. (AMH)

  16. Vigencia del Darwinismo

    OpenAIRE

    Lessa, Enrique P

    2009-01-01

    En este ensayo se presenta una revisión histórica del signifcado y legado del darwinismo, con énfasis en el último siglo. La principal conclusión es que la visión darwiniana de la evolución, con las modifcaciones requeridas para dar cuenta de los grandes desarrollos de la disciplina, se ha impuesto y mantiene vigencia en nuestros días. En particular, el papel del azar, la evolución como proceso de “descendencia con modifcación” a lo largo de diversas ramas del árbol de la vida, el pensamiento...

  17. Traces of Drosophila Memory

    Science.gov (United States)

    Davis, Ronald L.

    2012-01-01

    Summary Studies using functional cellullar imaging of living flies have identified six memory traces that form in the olfactory nervous system after conditioning with odors. These traces occur in distinct nodes of the olfactory nervous system, form and disappear across different windows of time, and are detected in the imaged neurons as increased calcium influx or synaptic release in response to the conditioned odor. Three traces form at, or near acquisition and co-exist with short-term behavioral memory. One trace forms with a delay after learning and co-exists with intermediate-term behavioral memory. Two traces form many hours after acquisition and co-exist with long-term behavioral memory. The transient memory traces may support behavior across the time-windows of their existence. The experimental approaches for dissecting memory formation in the fly, ranging from the molecular to the systems, make it an ideal system for dissecting the logic by which the nervous system organizes and stores different temporal forms of memory. PMID:21482352

  18. Are subjective memory problems related to suggestibility, compliance, false memories, and objective memory performance?

    Science.gov (United States)

    Van Bergen, Saskia; Jelicic, Marko; Merckelbach, Harald

    2009-01-01

    The relationship between subjective memory beliefs and suggestibility, compliance, false memories, and objective memory performance was studied in a community sample of young and middle-aged people (N = 142). We hypothesized that people with subjective memory problems would exhibit higher suggestibility and compliance levels and would be more susceptible to false recollections than those who are optimistic about their memory. In addition, we expected a discrepancy between subjective memory judgments and objective memory performance. We found that subjective memory judgments correlated significantly with compliance, with more negative memory judgments accompanying higher levels of compliance. Contrary to our expectation, subjective memory problems did not correlate with suggestibility or false recollections. Furthermore, participants were accurate in estimating their objective memory performance.

  19. Characterizing Memory Usage Behavior in Memory-related Code Changes

    OpenAIRE

    Wong, Howard Wah

    2017-01-01

    With the heavy memory pressure produced by multi-core systems and with memory per- formance trailing processor performance, today’s application developers need to consider the memory subsystem during software development. In particular, optimizing software re- quires a deep understanding of how the software uses the memory and how the hardware satisfies the memory requests. In order to accelerate development, programmers rely on soft- ware tools such as profilers for insightful analysis. Howe...

  20. Documenting a Contested Memory

    DEFF Research Database (Denmark)

    Awad, Sarah H.

    2017-01-01

    This article looks at how symbols in the urban environment are intentionally produced and modified to regulate a community’s collective memory. Our urban environment is filled with symbols in the form of images, text, and structures that embody certain narratives about the past. Once those symbols...... to preserve the memory of the revolution through graffiti murals and the utilization of public space, and from the other, the authority’s efforts to replace those initiatives with its own official narrative. Building on the concept of collective memory, as well as Bartlett’s studies of serial reproductions...

  1. Imagined memories of painting

    OpenAIRE

    Horta, Maia Schmidt, 1974-

    2011-01-01

    Tese de mestrado, Pintura, Universidade de Lisboa, Faculdade de Belas Artes, 2011 A Tese é compsota por dois volumes, um em portugês, outro em inglês Visual imagery, narratives and locations have always been linked to the study of memory. Memory has always been linked to art history and historical shifts in the study of memory had a direct impact on the history of painting. Painting was based on stories and served to make those stories memorable. Since then there have been numerous inve...

  2. European Union of Memories?

    DEFF Research Database (Denmark)

    Wæhrens, Anne

    After a very brief introduction to history and memory in Europe after 1989, as seen by Aleida Assmann, I will give a short introduction to the EP and to their adoption of resolutions and declarations. Then I will define some concepts central to my study before I proceed to the analysis. Finally I...... these changes have come about. Moreover, I show that there seems to be a political memory split between Left and Right and I suggest that the time might not be ripe for a shared European memory....

  3. Eliciting Sound Memories.

    Science.gov (United States)

    Harris, Anna

    2015-11-01

    Sensory experiences are often considered triggers of memory, most famously a little French cake dipped in lime blossom tea. Sense memory can also be evoked in public history research through techniques of elicitation. In this article I reflect on different social science methods for eliciting sound memories such as the use of sonic prompts, emplaced interviewing, and sound walks. I include examples from my research on medical listening. The article considers the relevance of this work for the conduct of oral histories, arguing that such methods "break the frame," allowing room for collaborative research connections and insights into the otherwise unarticulatable.

  4. Reduced False Memory after Sleep

    Science.gov (United States)

    Fenn, Kimberly M.; Gallo, David A.; Margoliash, Daniel; Roediger, Henry L., III; Nusbaum, Howard C.

    2009-01-01

    Several studies have shown that sleep contributes to the successful maintenance of previously encoded information. This research has focused exclusively on memory for studied events, as opposed to false memories. Here we report three experiments showing that sleep reduces false memories in the Deese-Roediger-McDermott (DRM) memory illusion. False…

  5. Organization and Memory in Adulthood.

    Science.gov (United States)

    Hultsch, David F.

    This paper discusses organizational processes and memory in general and organizational processes and adult age differences in memory in particular. The simplest analysis of memory is to divide the process into two parts: storage and retrieval. Studies show that the limitation of memory lies primarily in retrieval rather than storage. Organization…

  6. The Composition of Episodic Memory.

    Science.gov (United States)

    Underwood, Benton J.; And Others

    This study examined the interrelationships among a number of episodic memory tasks and among various attributes of memory. A sample of 200 college students was tested for ten sessions; 28 different measures of episodic memory were obtained. In addition, five measures of semantic memory were available. Results indicated that episodic and semantic…

  7. Memory colours affect colour appearance.

    Science.gov (United States)

    Witzel, Christoph; Olkkonen, Maria; Gegenfurtner, Karl R

    2016-01-01

    Memory colour effects show that colour perception is affected by memory and prior knowledge and hence by cognition. None of Firestone & Scholl's (F&S's) potential pitfalls apply to our work on memory colours. We present a Bayesian model of colour appearance to illustrate that an interaction between perception and memory is plausible from the perspective of vision science.

  8. Memory reconsolidation mediates the updating of hippocampal memory content

    Directory of Open Access Journals (Sweden)

    Jonathan L C Lee

    2010-11-01

    Full Text Available The retrieval or reactivation of a memory places it into a labile state, requiring a process of reconsolidation to restabilize it. This retrieval-induced plasticity is a potential mechanism for the modification of the existing memory. Following previous data supportive of a functional role for memory reconsolidation in the modification of memory strength, here I show that hippocampal memory reconsolidation also supports the updating of contextual memory content. Using a procedure that separates the learning of pure context from footshock-motivated contextual fear learning, I demonstrate doubly dissociable hippocampal mechanisms of initial context learning and subsequent updating of the neutral contextual representation to incorporate the footshock. Contextual memory consolidation was dependent upon BDNF expression in the dorsal hippocampus, whereas the footshock modification of the contextual representation required the expression of Zif268. These mechanisms match those previously shown to be selectively involved in hippocampal memory consolidation and reconsolidation, respectively. Moreover, memory reactivation is a necessary step in modifying memory content, as inhibition of hippocampal synaptic protein degradation also prevented the footshock-mediated memory modification. Finally, dorsal hippocampal knockdown of Zif268 impaired the reconsolidation of the pure contextual memory only under conditions of weak context memory training, as well as failing to disrupt contextual freezing when a strong contextual fear memory is reactivated by further conditioning. Therefore, an adaptive function of the reactivation and reconsolidation process is to enable the updating of memory content.

  9. La luz del origen del universo

    Directory of Open Access Journals (Sweden)

    Casas, Alberto

    2015-10-01

    Full Text Available Penzias and Wilson discovered the cosmic microwave background, a luminous echo of the Big Bang, in 1965. The amount of information encoded in this relic of the early universe is truly extraordinary. At present, the most precise data about the origin and structure of the universe comes from the study of this primordial light, the full potential of which has yet to be explored.En 1965 se descubrió el fondo de radiación de microondas, un eco luminoso de la Gran Explosión (Big Bang. La cantidad de información contenida en esta reliquia del universo primitivo es verdaderamente extraordinaria. En la actualidad los datos más precisos sobre el origen y estructura del universo provienen del estudio de esta luz primigenia, que aún no ha sido explorada en todo su potencial.

  10. Archivo del Duelo

    OpenAIRE

    Ferrera, Tamara

    2010-01-01

    Photos taken from the Archive of Mourning following the March 11 terrorist attacks El Archivo del Duelo. Creación de un archivo etnográfico de los Atentados del 11 de marzo en Madrid. Ministerio de Educación y Ciencia HUM2005-03490.

  11. Displasias del seno

    Directory of Open Access Journals (Sweden)

    Ernesto Andrade Valderrama

    1971-04-01

    Full Text Available En general, las Displasias no se presentan antes de la iniciación del estímulo Gonadal y tienden a desaparecer con el climaterio. Se definen entonces como las afecciones benignas del Seno, de origen endocrino.

  12. Memory training with senior citizens

    OpenAIRE

    CHOVANCOVÁ, Lenka

    2014-01-01

    This is a theoretical work. It deals with the topics of senior citizens and the aging process in an abbreviated conception, periodization of old age, and active life of seniors. It describes forms of social work with seniors in medical facilities, home environments and communities, and in old people's homes. Further, it describes memory: its definition, types of memory, memory loss, reasons why people forget, work with memory and advice on memory improvement from the medical point of view. Th...

  13. Josephson Thermal Memory

    Science.gov (United States)

    Guarcello, Claudio; Solinas, Paolo; Braggio, Alessandro; Di Ventra, Massimiliano; Giazotto, Francesco

    2018-01-01

    We propose a superconducting thermal memory device that exploits the thermal hysteresis in a flux-controlled temperature-biased superconducting quantum-interference device (SQUID). This system reveals a flux-controllable temperature bistability, which can be used to define two well-distinguishable thermal logic states. We discuss a suitable writing-reading procedure for these memory states. The time of the memory writing operation is expected to be on the order of approximately 0.2 ns for a Nb-based SQUID in thermal contact with a phonon bath at 4.2 K. We suggest a noninvasive readout scheme for the memory states based on the measurement of the effective resonance frequency of a tank circuit inductively coupled to the SQUID. The proposed device paves the way for a practical implementation of thermal logic and computation. The advantage of this proposal is that it represents also an example of harvesting thermal energy in superconducting circuits.

  14. Models of Working Memory

    National Research Council Canada - National Science Library

    Miyake, Akira

    1997-01-01

    Working memory is a basic cognitive mechanism (or set of mechanisms) that is responsible for keeping track of multiple task related goals and subgoals, or integrating multiple sources of information...

  15. Memory Circuit Fault Simulator

    Science.gov (United States)

    Sheldon, Douglas J.; McClure, Tucker

    2013-01-01

    Spacecraft are known to experience significant memory part-related failures and problems, both pre- and postlaunch. These memory parts include both static and dynamic memories (SRAM and DRAM). These failures manifest themselves in a variety of ways, such as pattern-sensitive failures, timingsensitive failures, etc. Because of the mission critical nature memory devices play in spacecraft architecture and operation, understanding their failure modes is vital to successful mission operation. To support this need, a generic simulation tool that can model different data patterns in conjunction with variable write and read conditions was developed. This tool is a mathematical and graphical way to embed pattern, electrical, and physical information to perform what-if analysis as part of a root cause failure analysis effort.

  16. Memory mass storage

    CERN Document Server

    Campardo, Giovanni; Iaculo, Massimo

    2011-01-01

    Covering all the fundamental storage technologies such as semiconductor, magnetic, optical and uncommon, this volume details their core characteristics. In addition, it includes an overview of the 'biological memory' of the human brain and its organization.

  17. Magnetic vortex racetrack memory

    Science.gov (United States)

    Geng, Liwei D.; Jin, Yongmei M.

    2017-02-01

    We report a new type of racetrack memory based on current-controlled movement of magnetic vortices in magnetic nanowires with rectangular cross-section and weak perpendicular anisotropy. Data are stored through the core polarity of vortices and each vortex carries a data bit. Besides high density, non-volatility, fast data access, and low power as offered by domain wall racetrack memory, magnetic vortex racetrack memory has additional advantages of no need for constrictions to define data bits, changeable information density, adjustable current magnitude for data propagation, and versatile means of ultrafast vortex core switching. By using micromagnetic simulations, current-controlled motion of magnetic vortices in cobalt nanowire is demonstrated for racetrack memory applications.

  18. Anatomy of Memory

    OpenAIRE

    J Gordon Millichap

    1991-01-01

    Studies of the anatomy and function of the brain system for memory in humans and animal models are reviewed from the Veterans Affairs Medical Center, San Diego and the Department of Psychiatry, University of California, San Diego, La Jolla, CA.

  19. Conglomerate memory and cosmopolitanism

    Directory of Open Access Journals (Sweden)

    Susannah Ryan

    2016-01-01

    Full Text Available Under what conditions do countries and cultures considered radically different find a basis for allegiance and kinship? What part does memory play in this process? This article responds to these questions in two ways: 1 Through Emmanuel Levinas and Hannah Arendt, I propose that when an other appears in empathetic discourses that both honor difference and cite shared human experiences, seemingly irreconcilable people can develop a sense of mutual responsibility and 2 Conglomerate memory, memories that fuse together others through common pains, contributes to such an appearance. To illustrate this point, I turn to Congolese voices as they are articulated in online American discourses; although currently, authors of online texts typically rely on traditional narrative forms that position Central Africa as incommensurate to Western civilizations, the Internet's worldwide accessibility and intertextual capacities render it a place primed for developing international collectives by connecting memories while maintaining difference.

  20. Iconic memory requires attention.

    Science.gov (United States)

    Persuh, Marjan; Genzer, Boris; Melara, Robert D

    2012-01-01

    Two experiments investigated whether attention plays a role in iconic memory, employing either a change detection paradigm (Experiment 1) or a partial-report paradigm (Experiment 2). In each experiment, attention was taxed during initial display presentation, focusing the manipulation on consolidation of information into iconic memory, prior to transfer into working memory. Observers were able to maintain high levels of performance (accuracy of change detection or categorization) even when concurrently performing an easy visual search task (low load). However, when the concurrent search was made difficult (high load), observers' performance dropped to almost chance levels, while search accuracy held at single-task levels. The effects of attentional load remained the same across paradigms. The results suggest that, without attention, participants consolidate in iconic memory only gross representations of the visual scene, information too impoverished for successful detection of perceptual change or categorization of features.

  1. Iconic memory requires attention

    Directory of Open Access Journals (Sweden)

    Marjan ePersuh

    2012-05-01

    Full Text Available Two experiments investigated whether attention plays a role in iconic memory, employing either a change-detection paradigm (Experiment 1 or a partial-report paradigm (Experiment 2. In each experiment, attention was taxed during initial display presentation, focusing the manipulation on consolidation of information into iconic memory, prior to transfer into working memory. Observers were able to maintain high levels of performance (accuracy of change detection or categorization even when concurrently performing an easy visual search task (low load. However, when the concurrent search was made difficult (high load, observers’ performance dropped to almost chance levels, while search accuracy held at single-task levels. The effects of attentional load remained the same across paradigms. The results suggest that, without attention, participants consolidate in iconic memory only gross representations of the visual scene, information too impoverished for successful detection of perceptual change or categorization of features.

  2. Working Memory and Neurofeedback.

    Science.gov (United States)

    YuLeung To, Eric; Abbott, Kathy; Foster, Dale S; Helmer, D'Arcy

    2016-01-01

    Impairments in working memory are typically associated with impairments in other cognitive faculties such as attentional processes and short-term memory. This paper briefly introduces neurofeedback as a treatment modality in general, and, more specifically, we review several of the current modalities successfully used in neurofeedback (NF) for the treatment of working memory deficits. Two case studies are presented to illustrate how neurofeedback is applied in treatment. The development of Low Resolution Electromagnetic Tomography (LORETA) and its application in neurofeedback now makes it possible to specifically target deep cortical/subcortical brain structures. Developments in neuroscience concerning neural networks, combined with highly specific yet practical NF technologies, makes neurofeedback of particular interest to neuropsychological practice, including the emergence of specific methodologies for treating very difficult working memory (WM) problems.

  3. Music and memory

    OpenAIRE

    Haefliger, Anna Berenika

    2013-01-01

    Abstract: Music and its different forms of use seem to benefit people in a number of ways. Research has suggested that extensive musical practice and musical listening enhances mental functioning in healthy adults and patients with neurodegenerative disease. Yet, the findings presented have not yet examined the effects both musical training and stimuli enhancement have on episodic memory recognition. 20 musicians and 20 non-musicians took part in an episodic memory task which evaluated m...

  4. Music evokes vivid autobiographical memories.

    Science.gov (United States)

    Belfi, Amy M; Karlan, Brett; Tranel, Daniel

    2016-08-01

    Music is strongly intertwined with memories-for example, hearing a song from the past can transport you back in time, triggering the sights, sounds, and feelings of a specific event. This association between music and vivid autobiographical memory is intuitively apparent, but the idea that music is intimately tied with memories, seemingly more so than other potent memory cues (e.g., familiar faces), has not been empirically tested. Here, we compared memories evoked by music to those evoked by famous faces, predicting that music-evoked autobiographical memories (MEAMs) would be more vivid. Participants listened to 30 songs, viewed 30 faces, and reported on memories that were evoked. Memories were transcribed and coded for vividness as in Levine, B., Svoboda, E., Hay, J. F., Winocur, G., & Moscovitch, M. [2002. Aging and autobiographical memory: Dissociating episodic from semantic retrieval. Psychology and Aging, 17, 677-689]. In support of our hypothesis, MEAMs were more vivid than autobiographical memories evoked by faces. MEAMs contained a greater proportion of internal details and a greater number of perceptual details, while face-evoked memories contained a greater number of external details. Additionally, we identified sex differences in memory vividness: for both stimulus categories, women retrieved more vivid memories than men. The results show that music not only effectively evokes autobiographical memories, but that these memories are more vivid than those evoked by famous faces.

  5. Laser memory (hologram) and coincident redundant multiplex memory (CRM-memory)

    International Nuclear Information System (INIS)

    Ostojic, Branko

    1975-01-01

    It is shown that besides the memory which remembers the object by memorising of the phases of the interferenting waves of the light (i.e. hologram) it is possible to construct the memory which remembers the object by memorising of the phases of the interferenting impulses (CFM-memory). It is given the mathematical description of the memory, based on the experimental model. Although in the paper only the technical aspect of CRM memory is given. It is mentioned the possibility that the human memory has the same principle and that the invention of CRM memory is due to cybernetical analysis of the system human eye-visual cortex

  6. Mechanisms of Memory Enhancement

    Science.gov (United States)

    Stern, Sarah A.

    2012-01-01

    The ongoing quest for memory enhancement is one that grows necessary as the global population increasingly ages. The extraordinary progress that has been made in the past few decades elucidating the underlying mechanisms of how long-term memories are formed has provided insight into how memories might also be enhanced. Capitalizing on this knowledge, it has been postulated that targeting many of the same mechanisms, including CREB activation, AMPA/NMDA receptor trafficking, neuromodulation (e.g. via dopamine, adrenaline, cortisol or acetylcholine) and metabolic processes (e.g. via glucose and insulin) may all lead to the enhancement of memory. These and other mechanisms and/or approaches have been tested via genetic or pharmacological methods in animal models, and several have been investigated in humans as well. In addition, a number of behavioral methods, including exercise and reconsolidation, may also serve to strengthen and enhance memories. By capitalizing on this knowledge and continuing to investigate these promising avenues, memory enhancement may indeed be achieved in the future. PMID:23151999

  7. Learning and memory

    Directory of Open Access Journals (Sweden)

    P. A. J. Ryke

    1989-03-01

    Full Text Available Under various circumstances and in different species the outward expression of learning varies considerably, and this has led to the classification of different categories of learning. Just as there is no generally agreed on definition of learning, there is no one system of classification. Types of learning commonly recognized are: Habituation, sensitization, classical conditioning, operant conditioning, trial and error, taste aversion, latent learning, cultural learning, imprinting, insight learning, learning-set learning and instinct. The term memory must include at least two separate processes. It must involve, on the one hand, that of learning something and on the other, at some later date, recalling that thing. What lies between the learning and (he remembering must be some permanent record — a memory trace — within the brain. Memory exists in at least two forms: memory for very recent events (short-term which is relatively labile and easily disruptable; and long-term memory, which is much more stable. Not everything that gets into short-term memory becomes fixed in the long-term store; a filtering mechanism selects things that might be important and discards the rest.

  8. Immune memory in invertebrates.

    Science.gov (United States)

    Milutinović, Barbara; Kurtz, Joachim

    2016-08-01

    Evidence for innate immune memory (or 'priming') in invertebrates has been accumulating over the last years. We here provide an in-depth review of the current state of evidence for immune memory in invertebrates, and in particular take a phylogenetic viewpoint. Invertebrates are a very heterogeneous group of animals and accordingly, evidence for the phenomenon of immune memory as well as the hypothesized molecular underpinnings differ largely for the diverse invertebrate taxa. The majority of research currently focuses on Arthropods, while evidence from many other groups of invertebrates is fragmentary or even lacking. We here concentrate on immune memory that is induced by pathogenic challenges, but also extent our view to a non-pathogenic context, i.e. allograft rejection, which can also show forms of memory and can inform us about general principles of specific self-nonself recognition. We discuss definitions of immune memory and a number of relevant aspects such as the type of antigens used, the route of exposure, and the kinetics of reactions following priming. Copyright © 2016 Elsevier Ltd. All rights reserved.

  9. False memories and confabulation.

    Science.gov (United States)

    Johnson, M K; Raye, C L

    1998-04-01

    Memory distortions range from the benign (thinking you mailed a check that you only thought about mailing), to the serious (confusing what you heard after a crime with what you actually saw), to the fantastic (claiming you piloted a spaceship). We review theoretical ideas and empirical evidence about the source monitoring processes underlying both true and false memories. Neuropsychological studies show that certain forms of brain damage (such as combined frontal and medial-temporal lesions) might result in profound source confusions, called confabulations. Neuroimaging techniques provide new evidence regarding more specific links between underlying brain mechanisms and the normal cognitive processes involved in evaluating memories. One hypothesis is that the right prefrontal cortex (PFC) subserves heuristic judgments based on easily assessed qualities (such as familiarity or perceptual detail) and the left PFC (or the right and left PFC together) subserves more systematic judgments requiring more careful analysis of memorial qualities or retrieval and evaluation of additional supporting or disconfirming information. Such heuristic and systematic processes can be disrupted not only by brain damage but also, for example, by hypnosis, social demands and motivational factors, suggesting caution in the methods used by `memory exploring' professions (therapists, police officers, lawyers, etc.) in order to avoid inducing false memories.

  10. Shape memory materials

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Compared with piezoelectric ceramics and magnetostrictive materials, the shape memory materials possess larger recoverable strain and recovery stress but slower response to external field. It is expected that the magneto-shape memory materials may develop considerable strain as well as rapid and precise shape control. Pseudoelasticity and shape memory effect (SME) resulted from martensitic transformation and its reverse transformation in shape memory materials were generally described. The requirements of appearing the shape memory effect in materials and the criteria for thermoelastic martensitic transformation were given. Some aspects concerning characteristics of martensitic transformation, and factors affecting SME in Ni-Ti, Cu-Zn-Al and Fe-Mn-Si based alloys as well as ZrO2 containing ceramics were briefly reviewed. Thermodynamic calculation of Ms temperature as function of grain size and parent ordering in Cu-Zn-Al was presented. The works on prediction of Ms in Fe-Mn-Si based alloys and in ZrO2-CeO2 were mentioned. Magnetic shape memory materials were briefly introduced.

  11. Magnetic vortex racetrack memory

    Energy Technology Data Exchange (ETDEWEB)

    Geng, Liwei D.; Jin, Yongmei M., E-mail: ymjin@mtu.edu

    2017-02-01

    We report a new type of racetrack memory based on current-controlled movement of magnetic vortices in magnetic nanowires with rectangular cross-section and weak perpendicular anisotropy. Data are stored through the core polarity of vortices and each vortex carries a data bit. Besides high density, non-volatility, fast data access, and low power as offered by domain wall racetrack memory, magnetic vortex racetrack memory has additional advantages of no need for constrictions to define data bits, changeable information density, adjustable current magnitude for data propagation, and versatile means of ultrafast vortex core switching. By using micromagnetic simulations, current-controlled motion of magnetic vortices in cobalt nanowire is demonstrated for racetrack memory applications. - Highlights: • Advance fundamental knowledge of current-driven magnetic vortex phenomena. • Report appealing new magnetic racetrack memory based on current-controlled magnetic vortices in nanowires. • Provide a novel approach to adjust current magnitude for data propagation. • Overcome the limitations of domain wall racetrack memory.

  12. Internet Journal of Medical Update

    African Journals Online (AJOL)

    admin

    This synoptic review of the pragmatic aspects of surgery will help students understand and remember better what they would have gleaned from weightier textbooks and formal lectures. The book is very readable, focused as it is on ... Sloan-Kettering, Dietl, Palomo and. Charcot, and non-English terms such as Sitz bath.

  13. La crisi del diritto del lavoro

    Directory of Open Access Journals (Sweden)

    Alessandro Garilli

    2012-01-01

    Full Text Available Riassunto - L’Autore ripercorre in chiave critica l’evoluzione delle politiche legislative in materia di lavoro, alla luce dell’attuale fase di crisi economico finanziaria. Nell’esaminare i principali interventi normativi attuati da inizio secolo, l’Autore mette in evidenza le scelte di metodo e gli elementi di continuità che accomunano i vari provvedimenti, individuandoli nell’affannosa ricerca del punto di equilibrio tra flessibilità e garantismo. La riflessione si chiude con alcuni interrogativi sulle ultime linee di riforma del mercato del lavoro e con l’auspicio che, anche al cospetto delle imprescindibili ragioni dell’economia, il diritto del lavoro possa continuare a svolgere il proprio tradizionale ruolo di disciplina di tutela della persona.   Abstract - The author analyzes, with a critically oriented approach, the development of the employment law, in the light of the current economic and financial crisis. In examining the main regulatory measures implemented since the beginning of the century, the author highlights the methodological choices and the elements of continuity that unite the various measures, focusing them in a hard research of a point of balance between flexibility and security. The discussion concludes with some questions about the last lines of the reform of the labor market and with the hope that, even in the face of compelling reasons of economy, labor law can continue to play its traditional role of governing the protection of person.

  14. OBJETIVO DEL DESARROLLO DEL MILENIO 7

    Directory of Open Access Journals (Sweden)

    Margarita M. Pérez O.

    2013-10-01

    Full Text Available Los Objetivos de Desarrollo del Milenio, también conocidos como los Objetivos del Milenio, constituyeron las metas finales que aprobaron los dirigentes mundiales, 189 jefes de estado y de gobierno en la Cumbre del Milenio de las Naciones Unidas celebrada en Nueva York en el año 2000, en la cual los Estados miembros de la organización reafirmaron su compromiso de luchar por un mundo en el que el desarrollo sostenible y la eliminación de la pobreza tuvieran máxima prioridad1 . En la cumbre se definió la Declaración del Milenio, la cual detalla los objetivos, principios, valores, metas y acciones para erradicar la pobreza Mundial hacia el año 2015, todos ellos ratificados con alto interés y acción estratégica de carácter global, como marco para la medición de los progresos en materia de desarrollo.

  15. Elementos del sistema electoral del Congreso Mexicano

    Directory of Open Access Journals (Sweden)

    Aldo Medina García

    2013-08-01

    Full Text Available El presente artículo es un estudio de los componentes del sistema electoral, diseñado por el legislador mexicano para integrar al parlamento federal. Estudio desarrollado a sabiendas de la importancia que reviste el sistema electoral como un medio que permite a los ciudadanos convertir su voto expresado en las urnas en escaños a favor de determinado candidato o partido. En dicho análisis tomamos en cuenta la evolución constitucional del sistema electoral mexicano, la participación de las fuerzas minoritarias en la integración del Senado y de la Cámara de Diputados, la división que se hace del territorio en circunscripciones electorales, la barrera electoral que se fija a los partidos políticos para acceder a la representación en el Parlamento, la fórmula de asignación que se aplica a la votación obtenida, para finalmente concluir que el sistema electoral mexicano es esencialmente mayoritario aun cuando se vista de proporcional.

  16. False memories for aggressive acts.

    Science.gov (United States)

    Laney, Cara; Takarangi, Melanie K T

    2013-06-01

    Can people develop false memories for committing aggressive acts? How does this process compare to developing false memories for victimhood? In the current research we used a simple false feedback procedure to implant false memories for committing aggressive acts (causing a black eye or spreading malicious gossip) or for victimhood (receiving a black eye). We then compared these false memories to other subjects' true memories for equivalent events. False aggressive memories were all too easy to implant, particularly in the minds of individuals with a proclivity towards aggression. Once implanted, the false memories were indistinguishable from true memories for the same events, on several dimensions, including emotional content. Implications for aggression-related memory more generally as well as false confessions are discussed. Copyright © 2013 Elsevier B.V. All rights reserved.

  17. Cultural heritage and memory: untangling the ties that bind

    Directory of Open Access Journals (Sweden)

    Viejo-Rose, Dacia

    2015-12-01

    Full Text Available Today in heritage studies memory looms larger than ever, there are memory parks, memory politics, and memory wars, there is discussion of ‘dissonant’, ‘dark’, and ‘difficult’ heritage linked to memories of traumatic past events. But what to we mean when we use the word ‘memory’ in the field of heritage? How is the divide between its social and individual realms bridged? This article theorizes the intimate relationship between heritage and memory by focusing on three areas. First, it maps out the vocabulary that has emerged from the heritage-memory dyad including how notions of collective memory and lieux de mémoire have been used, and occasionally misused, as well as the metaphors employed in the process. Second, the emergence of memory studies is considered, providing a brief overview of its foundations as well as assessing how it differs from, overlaps with, and contributes to heritage research. A third section offers a brief review of recent developments in cognitive psychology, neuroscience, and evolutionary biology relating to memory and how this might inform heritage studies. The concluding discussion provides a synthesis of the theoretical and empirical contribution of memory research to furthering out understanding of cultural heritage and proposes directions for future work on the area of confluence between the two.La memoria impregna hoy como nunca antes los estudios del patrimonio. Hay parques, políticas y guerras de la memoria. Se habla de un patrimonio “disonante”, “oscuro” o “difícil” vinculado al recuerdo de pasados sucesos traumáticos. Pero, ¿a qué nos referimos cuando usamos la palabra “memoria” en el campo del patrimonio? ¿Cómo se cruza el abismo que separa sus dimensiones social e individual? Este artículo teoriza sobre la íntima relación entre patrimonio y memoria, centrándose en tres áreas. La primera cartografía el vocabulario generado por la díada patrimonio-memoria, incluido

  18. Castillo del Real. Olocau

    OpenAIRE

    AUÑÓN VALLEJO, JONATAN

    2012-01-01

    El objetivo que se quiere alcanzar con este proyecto es el de realizar un estudio lo más cercano posible del Catillo del Real, de manera que se pueda conocer su origen, su evolución a lo largo de la historia, así como las diferentes técnicas y sistemas constructivos utilizados en su construcción. Auñón Vallejo, J. (2011). Castillo del Real. Olocau. http://hdl.handle.net/10251/14244. Archivo delegado

  19. La Representabilidad del Genocidio

    OpenAIRE

    Cardona González, Lorena

    2012-01-01

    El presente artículo intenta hacer una aproximación histórica y analítica al fenómeno del Genocidio, sus implicaciones sociales y culturales que dieron como resultado la reformulación analítica y conceptual de hechos que hasta entonces superaban el conocimiento y la moral humana. De este modo, se hace un trayecto histórico de la paulatina aparición del asesinato masivo como practica de Estado, enmarcado en las experiencias del genocidio armenio y el alemán. A su vez, se hace una mirada sobre ...

  20. Significado presente del CSIC

    OpenAIRE

    Garrido Gallardo, Miguel Angel

    2000-01-01

    Not available

    Este artículo, elaborado en 1999, ofrece una panorámica de la realidad del Consejo Superior de Investigaciones Científicas en la actualidad. Repasa su organización, su volumen de publicaciones, sus indicadores de productividad, su capacidad de obtener recursos y, en suma, su lugar en el conjunto del sistema español de Ciencia y Tecnología, considerado en sí mismo y en relación con la Universidad. Como conclusión del repaso de datos, se afirma que, aunque la fó...

  1. Tratamiento del pie equino

    OpenAIRE

    Robles, Fernanda

    2012-01-01

    El pie equino varo es una patología frecuente en los pacientes con Encefalopatía crónica no evolutiva (ECNE).Se observó que existe una mayor frecuencia en el sexo masculino. Se realizó un estudio descriptivo, comparativo y secundario, durante el periodo de septiembre del 2006 a septiembre del 2011, con un total de 125 pacientes con Ecne, de los cuales se encontraron 101 con pie equino varo congénito. Objetivo: observar los resultados obtenidos en la rehabilitación del pie equino, en niños de ...

  2. Del Pasadismo al Futurismo

    OpenAIRE

    Agudo-Martínez, M. J.

    2003-01-01

    Uno de los habituales prejuicios a la hora de abordar el análisis del movimiento futurista, al igual que sucede con el constructivismo, es la consideración del contexto político en el que se desarrollaron ambas vanguardias. Sin embargo, y dejando a un lado un enfoque del arte con finalidad política de signo diverso, habría que insistir en el hecho de que posiblemente sean tanto el futurismo italiano como el constructivismo ruso, los movimientos que con mayor entusiasmo se manifestaron, en un ...

  3. Embodied memory: unconscious smiling modulates emotional evaluation of episodic memories

    KAUST Repository

    Arminjon, Mathieu

    2015-05-26

    Since Damasio introduced the somatic markers hypothesis in Damasio (1994), it has spread through the psychological community, where it is now commonly acknowledged that somatic states are a factor in producing the qualitative dimension of our experiences. Present actions are emotionally guided by those somatic states that were previously activated in similar experiences. In this model, somatic markers serve as a kind of embodied memory. Here, we test whether the manipulation of somatic markers can modulate the emotional evaluation of negative memories. Because facial feedback has been shown to be a powerful means of modifying emotional judgements, we used it to manipulate somatic markers. Participants first read a sad story in order to induce a negative emotional memory and then were asked to rate their emotions and memory about the text. Twenty-four hours later, the same participants were asked to assume a predetermined facial feedback (smiling) while reactivating their memory of the sad story. The participants were once again asked to fill in emotional and memory questionnaires about the text. Our results showed that participants who had smiled during memory reactivation later rated the text less negatively than control participants. However, the contraction of the zygomaticus muscles during memory reactivation did not have any impact on episodic memory scores. This suggests that manipulating somatic states modified emotional memory without affecting episodic memory. Thus, modulating memories through bodily states might pave the way to studying memory as an embodied function and help shape new kinds of psychotherapeutic interventions.

  4. Memory reflected in our decisions

    Directory of Open Access Journals (Sweden)

    Todd McElroy

    2010-04-01

    Full Text Available The current study looks at the role working memory plays in risky-choice framing. Eighty-six participants took the Automatic OSPAN, a measurement of working memory; this was followed by a risky-choice framing task. Participants with high working memory capacities demonstrated well pronounced framing effects, while those with low working memory capacities did not. This pattern suggests that, in a typical risky-choice decision task, elaborative encoding of task information by those with high working memory capacity may lead them to a more biased decision compared to those with low working memory.

  5. Neurocognitive architecture of working memory

    Science.gov (United States)

    Eriksson, Johan; Vogel, Edward K.; Lansner, Anders; Bergström, Fredrik; Nyberg, Lars

    2015-01-01

    The crucial role of working memory for temporary information processing and guidance of complex behavior has been recognized for many decades. There is emerging consensus that working memory maintenance results from the interactions among long-term memory representations and basic processes, including attention, that are instantiated as reentrant loops between frontal and posterior cortical areas, as well as subcortical structures. The nature of such interactions can account for capacity limitations, lifespan changes, and restricted transfer after working-memory training. Recent data and models indicate that working memory may also be based on synaptic plasticity, and that working memory can operate on non-consciously perceived information. PMID:26447571

  6. Quantum Channels With Memory

    International Nuclear Information System (INIS)

    Rybar, T.

    2012-01-01

    Quantum memory channels represent a very general, yet simple and comprehensible model for causal processes. As such they have attracted considerable research interest, mostly aimed on their transfer capabilities and structure properties. Most notably it was shown that memory channels can be implemented via physically naturally motivated collision models. We also define the concept of repeatable channels and show that only unital channels can be implemented repeat ably with pure memory channels. In the special case of qubit channels we also show that every unital qubit channel has a repeatable implementation. We also briefly explore the possibilities of stroboscopical simulation of channels and show that all random unitary channels can be stroboscopically simulated. Particularly in qubit case, all indivisible qubit channels are also random unitary, hence for qubit all indivisible channels can be stroboscopically simulated. Memory channels also naturally capture the framework of correlated experiments. We develop methods to gather and interpret data obtained in such setting and in detail examine the two qubit case. We also show that for control unitary interactions the measured data will never contradict a simple unitary evolution. Thus no memory effects can be spotted then. (author)

  7. A balanced memory network.

    Directory of Open Access Journals (Sweden)

    Yasser Roudi

    2007-09-01

    Full Text Available A fundamental problem in neuroscience is understanding how working memory--the ability to store information at intermediate timescales, like tens of seconds--is implemented in realistic neuronal networks. The most likely candidate mechanism is the attractor network, and a great deal of effort has gone toward investigating it theoretically. Yet, despite almost a quarter century of intense work, attractor networks are not fully understood. In particular, there are still two unanswered questions. First, how is it that attractor networks exhibit irregular firing, as is observed experimentally during working memory tasks? And second, how many memories can be stored under biologically realistic conditions? Here we answer both questions by studying an attractor neural network in which inhibition and excitation balance each other. Using mean-field analysis, we derive a three-variable description of attractor networks. From this description it follows that irregular firing can exist only if the number of neurons involved in a memory is large. The same mean-field analysis also shows that the number of memories that can be stored in a network scales with the number of excitatory connections, a result that has been suggested for simple models but never shown for realistic ones. Both of these predictions are verified using simulations with large networks of spiking neurons.

  8. Aging accelerates memory extinction and impairs memory restoration in Drosophila.

    Science.gov (United States)

    Chen, Nannan; Guo, Aike; Li, Yan

    2015-05-15

    Age-related memory impairment (AMI) is a phenomenon observed from invertebrates to human. Memory extinction is proposed to be an active inhibitory modification of memory, however, whether extinction is affected in aging animals remains to be elucidated. Employing a modified paradigm for studying memory extinction in fruit flies, we found that only the stable, but not the labile memory component was suppressed by extinction, thus effectively resulting in higher memory loss in aging flies. Strikingly, young flies were able to fully restore the stable memory component 3 h post extinction, while aging flies failed to do so. In conclusion, our findings reveal that both accelerated extinction and impaired restoration contribute to memory impairment in aging animals. Copyright © 2015 Elsevier Inc. All rights reserved.

  9. Working Memory Influences on Long-Term Memory and Comprehension

    National Research Council Canada - National Science Library

    Radvansky, Gabriel

    2004-01-01

    .... This study looked at how comprehension and memory processing at the mental model level is related to traditional measures of working memory capacity, including the word span, reading span, operation...

  10. Multistate Resistive Switching Memory for Synaptic Memory Applications

    KAUST Repository

    Hota, Mrinal Kanti; Hedhili, Mohamed N.; Wehbe, Nimer; McLachlan, Martyn A.; Alshareef, Husam N.

    2016-01-01

    memory performance is observed. Conventional synaptic operation in terms of potentiation, depression plasticity, and Ebbinghaus forgetting process are also studied. The memory mechanism is shown to originate from the migration of the oxygen vacancies

  11. Behavioural memory reconsolidation of food and fear memories.

    Science.gov (United States)

    Flavell, Charlotte R; Barber, David J; Lee, Jonathan L C

    2011-10-18

    The reactivation of a memory through retrieval can render it subject to disruption or modification through the process of memory reconsolidation. In both humans and rodents, briefly reactivating a fear memory results in effective erasure by subsequent extinction training. Here we show that a similar strategy is equally effective in the disruption of appetitive pavlovian cue-food memories. However, systemic administration of the NMDA receptor partial agonist D-cycloserine, under the same behavioural conditions, did not potentiate appetitive memory extinction, suggesting that reactivation does not enhance subsequent extinction learning. To confirm that reactivation followed by extinction reflects a behavioural analogue of memory reconsolidation, we show that prevention of contextual fear memory reactivation by the L-type voltage-gated calcium channel blocker nimodipine interferes with the amnestic outcome. Therefore, the reconsolidation process can be manipulated behaviourally to disrupt both aversive and appetitive memories. © 2011 Macmillan Publishers Limited. All rights reserved.

  12. Memory Loss: 7 Tips to Improve Your Memory

    Science.gov (United States)

    ... re not alone. Everyone forgets things occasionally. Still, memory loss is nothing to take lightly. Although there are no guarantees when it comes to preventing memory loss or dementia, certain activities might help. Consider ...

  13. Preferencias del Turista

    Directory of Open Access Journals (Sweden)

    Jose Luis Leiva Olivencia

    2015-01-01

    Full Text Available Actualmente existen aplicaciones orientadas al turismo basadas en realidad aumentada, pero no integran técnicas de recomendación. Este articulo describe RAMCAT (Realidad Aumentada Móvil Contextual Aplicada al Turismo un modelo de guía turística, que recomienda puntos de interés, teniendo en cuenta factores como preferencias personales y atributos contextuales. Se presentan los componentes teóricos de la arquitectura propuesta, así como sus características, destacando la integración de diferentes sistemas de recomendación, que permiten añadir nuevos motores en el futuro. El articulo se centra en describir sus funcionalidades y el modulo correspondiente al sistema de recomendación basado en el perfil del turista. Otra característica importante del sistema propuesto es la retroalimentación del mismo mediante calificaciones del turista y su trazabilidad.

  14. Carta del Editor

    Directory of Open Access Journals (Sweden)

    Luis Eladio Proaño

    2015-01-01

    Full Text Available La millonaria contratación del futbolista David Beckham, un fenómeno del mercado, ha provocado cuestionamientos a los que se busca respuesta. Es tema de análisis el por qué el betseller "Harry Potter" ha causado tanta conmoción en la opinión pública. Respecto al periodista cibernético, se señalan los contornos del presente y atisban las posibilidades del futuro de esta nueva profesión. El tratamiento de los mitos de la prensa, los temores de la Ley mordaza venezolana y la brutalidad de los video juegos e Internet son temas de enorme interés. Se comenta las pocas veces que la prensa reflexiona sobre la comunicación corporal y la anorexia.

  15. Los muertos del Floreanismo

    Directory of Open Access Journals (Sweden)

    Enrique Ayala Mora

    2008-06-01

    Full Text Available El artículo analiza el crimen político durante las primeras décadas de vida de la República del Ecuador. Específicamente centra su estudio en el período dominado por la figura de Juan José Flores, primer presidente del Ecuador. La inestabilidad política, la precariedad de las alianzas entre las élites regionales, la crisis económica generada por las guerras de Independencia, las conspiraciones y la violencia que caracterizaron al período de surgimiento de las repúblicas andinas hicieron del crimen político un “vicio de nacimiento”. El asesinato del general Antonio José de Sucre, la muerte de los miembros de la sociedad El Quiteño Libre, el homicidio de Juan Otamendi, entre otros, hicieron patente esta característica.

  16. Niveles del aprendizaje organizacional

    OpenAIRE

    Garzón Castrillón, Manuel Alfonso

    2005-01-01

    En la propuesta de modelo de aprendizaje organizacional (AO), la segunda variable se denomina niveles del aprendizaje organizacional ; los niveles de aprendizaje que contemplamos para nuestra investigación son: individual, de equipo, organizacional e interorganizacional.

  17. La escritura del Yo

    Directory of Open Access Journals (Sweden)

    Patricio Landaeta Mardones

    2013-11-01

    Full Text Available Si la creación de una imagen fidedigna del mundo fue la condición de la conquista cognitiva y económica de la tierra, las imágenes mediáticas circulan hoy en día a la manera de un montaje que organiza los sujetos como elementos de un territorio. En esta presentación abordaremos el cruce entre estos dos hechos, entre la escritura del mundo y la de los sujetos, a partir de la idea de Fabulación para mostrar otra escritura del mundo y del yo, leyendo textos e imágenes de la Primera buena Corónica y Buen Gobierno de Felipe Guaman Poma de Ayala.

  18. Negative affect impairs associative memory but not item memory.

    OpenAIRE

    Bisby, J. A.; Burgess, N.

    2014-01-01

    The formation of associations between items and their context has been proposed to rely on mechanisms distinct from those supporting memory for a single item. Although emotional experiences can profoundly affect memory, our understanding of how it interacts with different aspects of memory remains unclear. We performed three experiments to examine the effects of emotion on memory for items and their associations. By presenting neutral and negative items with background contexts, Experiment 1 ...

  19. Wormholes in Memory: Is memory one representation or many?

    OpenAIRE

    Wulff Dirk U. Hills Thomas T. Hertwig Ralph

    2013-01-01

    The analogy of space to human cognition has a long standing tradition. Our study aims to elaborate on the validity of this analogy for search in memory. Using the search of associative memory framework (SAM) we show that people are able to dynamically recruit independent memory representations in the recall of country names. By instructing participants to use specific recall cues we also show that despite a strong effect on the retrieval sequence total recall from memory remains unaffected. ...

  20. Consideraciones alrededor del Libro del Almismo, el Libro del Pensar.

    Directory of Open Access Journals (Sweden)

    MartaLucía Tamayo Fernandez

    1999-12-01

    Full Text Available

    La doctora MarthaLucía Tamayo comparte muchas inquietudes alrededor del Libro del Almismo, el Libro del Pensar; de dónde salió ese nombre; de juntar en medicina y en genética a tres escritores como lo son Jorge Luis Borges, Macedonio Fernández y Julio Cortázar. Su conferencia dice así:

    El término almismo fue ideado por Macedonio Fernández porque defendía mucho el ensimismamiento y el pensamiento hacia el interior, mirar hacia adentro; cada uno somos un “sí mismo” que nos hace diferentes aunque al mismo tiempo podemos ser iguales. Todos tenemos esa parte interior que la medicina debe trabajar y que no puede olvidar.

    “El Libro del Almismo, el libro del pensar” nos lleva a replantear y a repensar un poco la medicina que queremos, una medicina vuelta a pensar.

    Quiero contarles la historia de cómo se llegó a este libro y por qué y para qué se sigue trabajando en estos temas: Después de mi internado y de un trabajo un poco triste de rural, volví al Instituto de Genética y a la Universidad Javeriana en donde encontré al doctor Bernal y un espacio que estaba buscando para esa medicina diferente que quería, con un grupo de personas que me permitía no sólo ver la medicina sino ver muchas otras cosas más; había espacio para la literatura, para Mafalda, para hablar de niños, de locos, había incluso tiempo para hablar de medicina dentro del golf, de carros antiguos y de todo eso fui aprendiendo.

    Eso era lo que estaba buscando. Una medicina que diera espacios diferentes, que fuera más humanizada. Rápidamente me ubiqué y me quedé! No me arrepiento en lo absoluto de haberme quedado porque fue, ha sido y sigue siendo, una experiencia enriquecedora, de muchas vivencias importantes. Sabía exactamente dónde estaba y sabía que había que seguir rápido y había que trabajar muchos aspectos de esa medicina que estábamos buscando y de esa genética especial.

    Rápidamente empezamos a trabajar

  1. Actualidad del relativismo cultural

    OpenAIRE

    Sánchez Durá, Nicolás

    2013-01-01

    Este ensayo tiene tres propósitos. En primer lugar, propone examinar las relaciones entre etnocentrismo y relativismo. El etnocentrismo puede tomar tres formas distintas: a saber, la de una universalidad impostada, la del exotismo y la de un particularismo narcisista exacerbado. El relativismo cultural es una postura que asume la inconmensurabilidad de los conceptos y valores que deben ser considerados como válidos dentro de las imágenes del mundo definidas. En segundo lugar, se argumenta que...

  2. Noradrenergic System and Memory

    KAUST Repository

    Zenger, Manuel

    2017-07-22

    There is ample evidence indicating that noradrenaline plays an important role in memory mechanisms. Noradrenaline is thought to modulate these procsses through activation of adrenergic receptors in neurons. Astrocytes that form essential partners for synaptic function, also express alpha- and beta-adrenergic receptors. In astrocytes, noradrenaline triggers metabolic actions such as the glycogenolysis leading to an increase in l-lactate formation and release. l-Lactate can be used by neurons as a sourc of energy during memory tasks and can also induc transcription of plasticity genes in neurons. Activation of β-adrenergic receptors can also trigger gliotransmitter release resulting of intracllular calcium waves. These gliotransmitters modulate the synaptic activity and thereby can modulate long-term potentiation mechanisms. In summary, recnt evidencs indicate that noradrenaline exerts its memory-promoting effects through different modes of action both on neurons and astrocytes.

  3. Noradrenergic System and Memory

    KAUST Repository

    Zenger, Manuel; Burlet-Godinot, Sophie; Petit, Jean-Marie; Magistretti, Pierre J.

    2017-01-01

    There is ample evidence indicating that noradrenaline plays an important role in memory mechanisms. Noradrenaline is thought to modulate these procsses through activation of adrenergic receptors in neurons. Astrocytes that form essential partners for synaptic function, also express alpha- and beta-adrenergic receptors. In astrocytes, noradrenaline triggers metabolic actions such as the glycogenolysis leading to an increase in l-lactate formation and release. l-Lactate can be used by neurons as a sourc of energy during memory tasks and can also induc transcription of plasticity genes in neurons. Activation of β-adrenergic receptors can also trigger gliotransmitter release resulting of intracllular calcium waves. These gliotransmitters modulate the synaptic activity and thereby can modulate long-term potentiation mechanisms. In summary, recnt evidencs indicate that noradrenaline exerts its memory-promoting effects through different modes of action both on neurons and astrocytes.

  4. Eavesdropping on Memory.

    Science.gov (United States)

    Loftus, Elizabeth F

    2017-01-03

    For more than four decades, I have been studying human memory. My research concerns the malleable nature of memory. Information suggested to an individual about an event can be integrated with the memory of the event itself, so that what actually occurred, and what was discussed later about what may have occurred, become inextricably interwoven, allowing distortion, elaboration, and even total fabrication. In my writings, classes, and public speeches, I've tried to convey one important take-home message: Just because someone tells you something in great detail, with much confidence, and with emotion, it doesn't mean that it is true. Here I describe my professional life as an experimental psychologist, in which I've eavesdropped on this process, as well as many personal experiences that may have influenced my thinking and choices.

  5. Echoic memory in pigeons.

    Science.gov (United States)

    Kretzschmar, Christina; Kalenscher, Tobias; Güntürkün, Onur; Kaernbach, Christian

    2008-10-01

    It is unknown whether birds are able to retain the memory of purely sensory auditory information such as white noise over an extended period of time. In a Pavlovian heart rate conditioning paradigm, four pigeons were trained to associate a mild electric shock with periodic random waveforms, and no shock with aperiodic noise. Periodic waveform detection requires echoic memory, i.e., the online retention of a waveform pattern over a limited time. Starting with 40ms, the waveform period was increased after successful learning until no significant stimulus discrimination could be found. Significant discrimination was achieved at periods of up to 2560ms. This is the first demonstration that echoic memory performance in birds is clearly superior to cats and gerbils, and comparable to naive human performance.

  6. Albert Einstein memorial lectures

    CERN Document Server

    Mechoulam, Raphael; The Israel Academy for Sciences and Humanities

    2012-01-01

    This volume consists of a selection of the Albert Einstein Memorial Lectures presented annually at the Israel Academy of Sciences and Humanities. Delivered by eminent scientists and scholars, including Nobel laureates, they cover a broad spectrum of subjects in physics, chemistry, life science, mathematics, historiography and social issues. This distinguished memorial lecture series was inaugurated by the Israel Academy of Sciences and Humanities following an international symposium held in Jerusalem in March 1979 to commemorate the centenary of Albert Einstein's birth. Considering that Einstein's interests, activities and influence were not restricted to theoretical physics but spanned broad fields affecting society and the welfare of humankind, it was felt that these memorial lectures should be addressed to scientists, scholars and erudite laypersons rather than to physicists alone.

  7. Functional memory metals

    International Nuclear Information System (INIS)

    Dunne, D.P.

    2000-01-01

    The field of shape memory phenomena in metals and alloys has developed in a sporadic fashion from a scientific curiosity to a vigorously growing niche industry, over a period close to a full working lifetime. Memory metal research and development is replete with scientist and engineer 'true believers', who can finally feel content that their longstanding confidence in the potential of these unusual functional materials has not been misplaced. This paper reviews the current range of medical and non-medical systems and devices which are based on memory metals and attempts to predict trends in applications over the next decade. The market is dominated by Ni Ti alloys which have proved to exhibit the best and most reproducible properties for application in a wide range of medical and non-medical devices

  8. Memory, Conviviality and Coexistence

    DEFF Research Database (Denmark)

    Duru, Deniz Neriman

    2016-01-01

    that postulates cohesion and conflict as rooted in ethnic and religious differences. It suggests ‘conviviality’ as the production of space, by arguing that hard times, tensions as well as sensorial pleasures produce a sense of belonging in a place, through shared ways of living. While memories of ‘coexistence......The article explores the narratives and memories of past diversity and current practices of conviviality to investigate how class, lifestyle and tastes affect the daily interactions between people belonging to different ethno-religious backgrounds. This chapter critiques ‘coexistence’ as a concept......’ emphasize the fragmentation of people into ethnic and religious groups as a consequence of the homogenization process in the post-Ottoman Turkish context, bitter sweet memories of conviviality create a sense of belonging to Burgaz....

  9. Emotion and autobiographical memory

    Science.gov (United States)

    Holland, Alisha C.; Kensinger, Elizabeth A.

    2010-03-01

    Autobiographical memory encompasses our recollections of specific, personal events. In this article, we review the interactions between emotion and autobiographical memory, focusing on two broad ways in which these interactions occur. First, the emotional content of an experience can influence the way in which the event is remembered. Second, emotions and emotional goals experienced at the time of autobiographical retrieval can influence the information recalled. We discuss the behavioral manifestations of each of these types of interactions and describe the neural mechanisms that may support those interactions. We discuss how findings from the clinical literature (e.g., regarding depression) and the social psychology literature (e.g., on emotion regulation) might inform future investigations of the interplay between the emotions experienced at the time of retrieval and the memories recalled, and we present ideas for future research in this domain.

  10. Matter and memory

    CERN Document Server

    Bergson, Henri

    1991-01-01

    Since the end of the last century," Walter Benjamin wrote, "philosophy has made a series of attempts to lay hold of the 'true' experience as opposed to the kind that manifests itself in the standardized, denatured life of the civilized masses. It is customary to classify these efforts under the heading of a philosophy of life. Towering above this literature is Henri Bergson's early monumental work, Matter and Memory."Along with Husserl's Ideas and Heidegger's Being and Time, Bergson's work represents one of the great twentieth-century investigations into perception and memory, movement and time, matter and mind. Arguably Bergson's most significant book, Matter and Memory is essential to an understanding of his philosophy and its legacy.This new edition includes an annotated bibliography prepared by Bruno Paradis.Henri Bergson (1859-1941) was awarded the Nobel Prize in 1927. His works include Time and Free Will, An Introduction to Metaphysics, Creative Evolution, and The Creative Mind.

  11. el Valle del Cauca

    Directory of Open Access Journals (Sweden)

    Carlos Humberto Ortiz

    2007-01-01

    Full Text Available Este artículo se enfoca en la identi- ficación de aquellos factores estructurales que explican la pérdida de dinamismo económico de largo plazo en Colombia y, en particular, en el Valle del Cauca. Se examina la competitividad del Valle en relación con Colombia y con el resto del mundo. Se cuestiona la insistencia en una estrategia exportadora como dinamizadora del desarrollo económico. Se identifica que una gran parte de la población está excluida de los beneficios del desarrollo económico. Para construir un modelo de desarrollo que incluya a esta población se recomienda recuperar la senda de la industrialización, invertir en el capital humano (educación de alta calidad, salud, salubridad y nutrición, e invertir en infraestructura. La participación del Estado en estas inversiones sociales es necesaria para disminuir la desigualdad y aumentar el crecimiento económico.

  12. Espectroscopia del Cometa Halley

    Science.gov (United States)

    Naranjo, O.; Fuenmayor, F.; Ferrin, L.; Bulka, P.; Mendoza, C.

    1987-05-01

    Se reportan observaciones espectroscópicas del cometa Halley. Los espectros fueron tomados usando el espectrógrafo del telescopio reflector de 1 metro del Observatorio Nacional de Venezuela. Se utilizó óptica azul, con una red de difracción de 600 lineas/min, obteniéndose una dispersión de 74.2 A/mm y una resolución de 2.5 A, en el rango espectral de 3500 a 6500 A. Seis placas fueron tomadas con emulsión IIa-O y dos con IIa-D. Los tiempos de exposición fueron entre 10 y 150 minutos. El cometa se encontraba entre 0.70 y 1.04 UA del Sol, y entre 1.28 y 0.73 UA de la Tierra. Las emisiones más prominentes en el espectro, son las del CN, C2, y C3. Otras emisiones detectadas corresponden a CH, NH2 y Na. Los espectros muestran un fuerte continuo, indicando un contenido significativo de polvo. Se detectó mayor intensidad del contínuo, en la dirección anti solar, lo cual es evidencia de la cola de polvo.

  13. Negative Affect Impairs Associative Memory but Not Item Memory

    Science.gov (United States)

    Bisby, James A.; Burgess, Neil

    2014-01-01

    The formation of associations between items and their context has been proposed to rely on mechanisms distinct from those supporting memory for a single item. Although emotional experiences can profoundly affect memory, our understanding of how it interacts with different aspects of memory remains unclear. We performed three experiments to examine…

  14. Aging memories: differential decay of episodic memory components

    NARCIS (Netherlands)

    Talamini, L.M.; Gorree, E.

    2012-01-01

    Some memories about events can persist for decades, even a lifetime. However, recent memories incorporate rich sensory information, including knowledge on the spatial and temporal ordering of event features, while old memories typically lack this "filmic" quality. We suggest that this apparent

  15. Inventario nacional del uso actual del agua

    OpenAIRE

    Oficina Nacional de Evaluación de Recursos Naturales

    1984-01-01

    Establece como se emplea el agua en el Perú, teniendo en cuenta el tipo de uso, consuntivo y no consuntivo, discriminando según sea el destino: agrícola, pecuario, poblacional,industrial, minero, energético y pesquero, así como su localización geográfica; ello con la finalidad de que sirva de información básica para la planificación del desarrollo.

  16. Gerencia del cuidado-gerencia del servicio

    Directory of Open Access Journals (Sweden)

    Marta Palmet Jiménez

    2016-01-01

    Full Text Available La gerencia de este siglo debe estar plenamente identificada con la administración para planear, organizar, decidir y obtener resultados definidos, evaluados y alcanzados a través de las personas. Para poder gerenciar el cuidado se debe saber administrar. El objetivo de enfermería es cuidar; el objetivo de la gerencia es la conducción de la producción de bienes o servicios en las organizaciones. La gerencia del cuidado implica: motivación, creatividad, responsabilidad y ética por parte del cuidador y de quien cuida, claridad de actitud frente al ser y al qué hacer por parte del cuidador. Se puede concluir que la gerencia (administración, el cuidado (producto de calidad, el servicio (valor intangible, querer servir son un trinomio que deben ir de la mano de manera integrada para el logro de los objetivos propuestos por la organización de salud y de enfermería.

  17. Time-Predictable Virtual Memory

    DEFF Research Database (Denmark)

    Puffitsch, Wolfgang; Schoeberl, Martin

    2016-01-01

    Virtual memory is an important feature of modern computer architectures. For hard real-time systems, memory protection is a particularly interesting feature of virtual memory. However, current memory management units are not designed for time-predictability and therefore cannot be used...... in such systems. This paper investigates the requirements on virtual memory from the perspective of hard real-time systems and presents the design of a time-predictable memory management unit. Our evaluation shows that the proposed design can be implemented efficiently. The design allows address translation...... and address range checking in constant time of two clock cycles on a cache miss. This constant time is in strong contrast to the possible cost of a miss in a translation look-aside buffer in traditional virtual memory organizations. Compared to a platform without a memory management unit, these two additional...

  18. Clinical Perspectives on Autobiographical Memory

    DEFF Research Database (Denmark)

    Autobiographical memory plays a key role in psychological well-being, and the field has been investigated from multiple perspectives for more than thirty years. One large body of research has examined the basic mechanisms and characteristics of autobiographical memory during general cognition......, and another body has studied what happens to it during psychological disorders, and how psychological therapies targeting memory disturbances can improve psychological well-being. This edited collection reviews and integrates current theories on autobiographical memory when viewed in a clinical perspective....... It presents an overview of basic applied and clinical approaches to autobiographical memory, covering memory specificity, traumatic memories, involuntary and intrusive memories, and the role of self-identity. The book discusses a wide range of psychological disorders, including depression, posttraumatic...

  19. Eldercare at Home: Memory Problems

    Science.gov (United States)

    ... following through with current events and activities. Often long-term memories of childhood or young adulthood remain vivid, even in the case of Alzheimer's disease, so it is short-term memory that is important to assess when ...

  20. Neuroepigenetic Regulation of Pathogenic Memories.

    Science.gov (United States)

    Sillivan, Stephanie E; Vaissière, Thomas; Miller, Courtney A

    2015-01-01

    Our unique collection of memories determines our individuality and shapes our future interactions with the world. Remarkable advances into the neurobiological basis of memory have identified key epigenetic mechanisms that support the stability of memory. Various forms of epigenetic regulation at the levels of DNA methylation, histone modification, and non-coding RNAs (ncRNAs) can modulate transcriptional and translational events required for memory processes. By changing the cellular profile in the brain's emotional, reward, and memory circuits, these epigenetic modifications have also been linked to perseverant, pathogenic memories. In this review, we will delve into the relevance of epigenetic dysregulation to pathogenic memory mechanisms by focusing on two neuropsychiatric disorders perpetuated by aberrant memory associations: substance use disorder (SUD) and post-traumatic stress disorder (PTSD). As our understanding improves, neuroepigenetic mechanisms may someday be harnessed to develop novel therapeutic targets for the treatment of these chronic, relapsing disorders.

  1. DNA methylation and memory formation.

    Science.gov (United States)

    Day, Jeremy J; Sweatt, J David

    2010-11-01

    Memory formation and storage require long-lasting changes in memory-related neuronal circuits. Recent evidence indicates that DNA methylation may serve as a contributing mechanism in memory formation and storage. These emerging findings suggest a role for an epigenetic mechanism in learning and long-term memory maintenance and raise apparent conundrums and questions. For example, it is unclear how DNA methylation might be reversed during the formation of a memory, how changes in DNA methylation alter neuronal function to promote memory formation, and how DNA methylation patterns differ between neuronal structures to enable both consolidation and storage of memories. Here we evaluate the existing evidence supporting a role for DNA methylation in memory, discuss how DNA methylation may affect genetic and neuronal function to contribute to behavior, propose several future directions for the emerging subfield of neuroepigenetics, and begin to address some of the broader implications of this work.

  2. Neuroepigenetic regulation of pathogenic memories

    Directory of Open Access Journals (Sweden)

    Stephanie E. Sillivan

    2015-01-01

    Full Text Available Our unique collection of memories determines our individuality and shapes our future interactions with the world. Remarkable advances into the neurobiological basis of memory have identified key epigenetic mechanisms that support the stability of memory. Various forms of epigenetic regulation at the levels of DNA methylation, histone modification, and noncoding RNAs can modulate transcriptional and translational events required for memory processes. By changing the cellular profile in the brain’s emotional, reward, and memory circuits, these epigenetic modifications have also been linked to perseverant, pathogenic memories. In this review, we will delve into the relevance of epigenetic dysregulation to pathogenic memory mechanisms by focusing on 2 neuropsychiatric disorders perpetuated by aberrant memory associations: substance use disorder and post-traumatic stress disorder. As our understanding improves, neuroepigenetic mechanisms may someday be harnessed to develop novel therapeutic targets for the treatment of these chronic, relapsing disorders.

  3. Emotional organization of autobiographical memory.

    Science.gov (United States)

    Schulkind, Matthew D; Woldorf, Gillian M

    2005-09-01

    The emotional organization of autobiographical memory was examined by determining whether emotional cues would influence autobiographical retrieval in younger and older adults. Unfamiliar musical cues that represented orthogonal combinations of positive and negative valence and high and low arousal were used. Whereas cue valence influenced the valence of the retrieved memories, cue arousal did not affect arousal ratings. However, high-arousal cues were associated with reduced response latencies. A significant bias to report positive memories was observed, especially for the older adults, but neither the distribution of memories across the life span nor response latencies varied across memories differing in valence or arousal. These data indicate that emotional information can serve as effective cues for autobiographical memories and that autobiographical memories are organized in terms of emotional valence but not emotional arousal. Thus, current theories of autobiographical memory must be expanded to include emotional valence as a primary dimension of organization.

  4. Transparent Memory For Harsh Electronics

    KAUST Repository

    Ho, C. H.; Duran Retamal, Jose Ramon; Yang, P. K.; Lee, C. P.; Tsai, M. L.; Kang, C. F.; He, Jr-Hau

    2017-01-01

    As a new class of non-volatile memory, resistive random access memory (RRAM) offers not only superior electronic characteristics, but also advanced functionalities, such as transparency and radiation hardness. However, the environmental tolerance

  5. Memory and Forgetfulness: NIH Research

    Science.gov (United States)

    ... of this page please turn Javascript on. Feature: Memory & Forgetfulness NIH Research Past Issues / Summer 2013 Table ... agency for research on Alzheimer's disease and related memory research. An analysis funded by the NIA finds ...

  6. noMemory

    OpenAIRE

    Fuglestad, Bjørn Nødland; Hillestad, Bendik Kiste; Stenshagen, Per-Arne Waaler

    2016-01-01

    noMemory is a project to create a strategy game in Unreal Engine 4. In this game, you control one or more heroes and units, and battle against another human player locally, or against an Artificial Intelligence. This thesis will go through this game from its inception as an idea, through its implementation, and conclude with our thoughts on the result and the journey there. noMemory er et prosjekt for å lage et strategi spill i Unreal Engine 4. I dette spillet kontrollerer du én eller fler...

  7. Shape memory effect alloys

    International Nuclear Information System (INIS)

    Koshimizu, S.

    1992-01-01

    Although the pseudo- or super-elasticity phenomena and the shape memory effect were known since the 1940's, the enormous curiosity and the great interest to their practical applications emerged with the development of the NITINOL alloy (Nickel-Titanium Naval Ordance Laboratory) by the NASA during the 1960's. This fact marked the appearance of a new class of materials, popularly known as shape memory effect alloys (SMEA). The objective of this work is to present a state-of-the-art of the development and applications for the SMEA. (E.O.)

  8. Bifurcation with memory

    International Nuclear Information System (INIS)

    Olmstead, W.E.; Davis, S.H.; Rosenblat, S.; Kath, W.L.

    1986-01-01

    A model equation containing a memory integral is posed. The extent of the memory, the relaxation time lambda, controls the bifurcation behavior as the control parameter R is increased. Small (large) lambda gives steady (periodic) bifurcation. There is a double eigenvalue at lambda = lambda 1 , separating purely steady (lambda 1 ) from combined steady/T-periodic (lambda > lambda 1 ) states with T → infinity as lambda → lambda + 1 . Analysis leads to the co-existence of stable steady/periodic states and as R is increased, the periodic states give way to the steady states. Numerical solutions show that this behavior persists away from lambda = lambda 1

  9. About sleep's role in memory.

    Science.gov (United States)

    Rasch, Björn; Born, Jan

    2013-04-01

    Over more than a century of research has established the fact that sleep benefits the retention of memory. In this review we aim to comprehensively cover the field of "sleep and memory" research by providing a historical perspective on concepts and a discussion of more recent key findings. Whereas initial theories posed a passive role for sleep enhancing memories by protecting them from interfering stimuli, current theories highlight an active role for sleep in which memories undergo a process of system consolidation during sleep. Whereas older research concentrated on the role of rapid-eye-movement (REM) sleep, recent work has revealed the importance of slow-wave sleep (SWS) for memory consolidation and also enlightened some of the underlying electrophysiological, neurochemical, and genetic mechanisms, as well as developmental aspects in these processes. Specifically, newer findings characterize sleep as a brain state optimizing memory consolidation, in opposition to the waking brain being optimized for encoding of memories. Consolidation originates from reactivation of recently encoded neuronal memory representations, which occur during SWS and transform respective representations for integration into long-term memory. Ensuing REM sleep may stabilize transformed memories. While elaborated with respect to hippocampus-dependent memories, the concept of an active redistribution of memory representations from networks serving as temporary store into long-term stores might hold also for non-hippocampus-dependent memory, and even for nonneuronal, i.e., immunological memories, giving rise to the idea that the offline consolidation of memory during sleep represents a principle of long-term memory formation established in quite different physiological systems.

  10. Constructive Memory: Past and Future

    OpenAIRE

    Schacter, Daniel L.

    2012-01-01

    Human memory is not a literal reproduction of the past, but instead relies on constructive processes that are sometimes prone to error and distortion. Understanding of constructive memory has accelerated during recent years as a result of research that has linked together its cognitive and neural bases. This article focuses on three aspects of constructive memory that have been the target of recent research: (i) the idea that certain kinds of memory distortions reflect the operation of adapti...

  11. Modularity in Sensory Auditory Memory

    OpenAIRE

    Clement, Sylvain; Moroni, Christine; Samson, Séverine

    2004-01-01

    The goal of this paper was to review various experimental and neuropsychological studies that support the modular conception of auditory sensory memory or auditory short-term memory. Based on initial findings demonstrating that verbal sensory memory system can be dissociated from a general auditory memory store at the functional and anatomical levels. we reported a series of studies that provided evidence in favor of multiple auditory sensory stores specialized in retaining eit...

  12. Self, Nation, and Generational Memory

    DEFF Research Database (Denmark)

    Böss/Bøss, Michael

    2014-01-01

    A study of the former Irish president Eamon de Valera's self-narrative in his official autobiography as an illustration Alistair Thomson's theory of memory as 'composure' and as reflecting generational memory........A study of the former Irish president Eamon de Valera's self-narrative in his official autobiography as an illustration Alistair Thomson's theory of memory as 'composure' and as reflecting generational memory.....

  13. Memory effects on stochastic resonance

    Science.gov (United States)

    Neiman, Alexander; Sung, Wokyung

    1996-02-01

    We study the phenomenon of stochastic resonance (SR) in a bistable system with internal colored noise. In this situation the system possesses time-dependent memory friction connected with noise via the fluctuation-dissipation theorem, so that in the absence of periodic driving the system approaches the thermodynamic equilibrium state. For this non-Markovian case we find that memory usually suppresses stochastic resonance. However, for a large memory time SR can be enhanced by the memory.

  14. Limited Memory, Categorization, and Competition

    OpenAIRE

    Yuxin Chen; Ganesh Iyer; Amit Pazgal

    2010-01-01

    This paper investigates the effects of a limited consumer memory on the price competition between firms. It studies a specific aspect of memory--namely, the categorization of available price information that the consumers may need to recall for decision making. This paper analyzes competition between firms in a market with uninformed consumers who do not compare prices, informed consumers who compare prices but with limited memory, and informed consumers who have perfect memory. Consumers, aw...

  15. Shape memory polymer medical device

    Science.gov (United States)

    Maitland, Duncan [Pleasant Hill, CA; Benett, William J [Livermore, CA; Bearinger, Jane P [Livermore, CA; Wilson, Thomas S [San Leandro, CA; Small, IV, Ward; Schumann, Daniel L [Concord, CA; Jensen, Wayne A [Livermore, CA; Ortega, Jason M [Pacifica, CA; Marion, III, John E.; Loge, Jeffrey M [Stockton, CA

    2010-06-29

    A system for removing matter from a conduit. The system includes the steps of passing a transport vehicle and a shape memory polymer material through the conduit, transmitting energy to the shape memory polymer material for moving the shape memory polymer material from a first shape to a second and different shape, and withdrawing the transport vehicle and the shape memory polymer material through the conduit carrying the matter.

  16. Origins of Adolescents' Autobiographical Memories

    Science.gov (United States)

    Reese, Elaine; Jack, Fiona; White, Naomi

    2010-01-01

    Adolescents (N = 46; M = 12.46 years) who had previously participated in a longitudinal study of autobiographical memory development narrated their early childhood memories, interpreted life events, and completed a family history questionnaire and language assessment. Three distinct components of adolescent memory emerged: (1) age of earliest…

  17. Episodic memory in nonhuman animals.

    Science.gov (United States)

    Templer, Victoria L; Hampton, Robert R

    2013-09-09

    Episodic memories differ from other types of memory because they represent aspects of the past not present in other memories, such as the time, place, or social context in which the memories were formed. Focus on phenomenal experience in human memory, such as the sense of 'having been there', has resulted in conceptualizations of episodic memory that are difficult or impossible to apply to nonhuman species. It is therefore a significant challenge for investigators to agree on objective behavioral criteria that can be applied in nonhuman animals and still capture features of memory thought to be critical in humans. Some investigators have attempted to use neurobiological parallels to bridge this gap; however, defining memory types on the basis of the brain structures involved rather than on identified cognitive mechanisms risks missing crucial functional aspects of episodic memory, which are ultimately behavioral. The most productive way forward is likely a combination of neurobiology and sophisticated cognitive testing that identifies the mental representations present in episodic memory. Investigators that have refined their approach from asking the naïve question "do nonhuman animals have episodic memory" to instead asking "what aspects of episodic memory are shared by humans and nonhumans" are making progress. Copyright © 2013 Elsevier Ltd. All rights reserved.

  18. NUMA obliviousness through memory mapping

    NARCIS (Netherlands)

    M.M. Gawade (Mrunal); M.L. Kersten (Martin)

    2015-01-01

    htmlabstractWith the rise of multi-socket multi-core CPUs a lot of effort is being put into how to best exploit their abundant CPU power. In a shared memory setting the multi-socket CPUs are equipped with their own memory module, and access memory modules across sockets in a non-uniform

  19. Play Memories and Place Identity.

    Science.gov (United States)

    Sandberg, Anette

    2003-01-01

    This retrospective study examined play memories from childhood to adulthood of 478 university students between ages 20 and 62 as exhibited in drawings of play memories and questionnaire responses. The study focused on the role of the physical environment and place identity in play memories and individual identity development. Findings showed that…

  20. Context Memory in Korsakoff's Syndrome

    NARCIS (Netherlands)

    Kessels, R.P.C.; Kopelman, M.D.

    2012-01-01

    Memory for contextual information and target-context integration are crucial for successful episodic memory formation and are impaired in patients with Korsakoff's syndrome. In this paper we review the evidence for the notion that a context memory deficit makes an important contribution to the

  1. Context memory in Korsakoff's syndrome.

    NARCIS (Netherlands)

    Kessels, R.P.C.; Kopelman, M.D.

    2012-01-01

    Memory for contextual information and target-context integration are crucial for successful episodic memory formation and are impaired in patients with Korsakoff's syndrome. In this paper we review the evidence for the notion that a context memory deficit makes an important contribution to the

  2. NUMA obliviousness through memory mapping

    NARCIS (Netherlands)

    Gawade, M.; Kersten, M.; Pandis, I.; Kersten, M.

    2015-01-01

    With the rise of multi-socket multi-core CPUs a lot of effort is being put into how to best exploit their abundant CPU power. In a shared memory setting the multi-socket CPUs are equipped with their own memory module, and access memory modules across sockets in a non-uniform access pattern (NUMA).

  3. Transacted Memory for Smart Cards

    NARCIS (Netherlands)

    Hartel, Pieter H.; Butler, Michael J.; de Jong, Eduard; Longley, Mark; Olivieira, J.N.; Zave, P.

    A transacted memory that is implemented using EEPROM technology offers persistence, undoability and auditing. The transacted memory system is formally specified in Z, and refined in two steps to a prototype C implementation / SPIN model. Conclusions are offered both on the transacted memory system

  4. Stroke and Episodic Memory Disorders

    Science.gov (United States)

    Lim, Chun; Alexander, Michael P.

    2009-01-01

    Memory impairments are common after stroke, and the anatomical basis for impairments may be quite variable. To determine the range of stroke-related memory impairment, we identified all case reports and group studies through the Medline database and the Science Citation Index. There is no hypothesis about memory that is unique to stroke, but there…

  5. Motor Action and Emotional Memory

    Science.gov (United States)

    Casasanto, Daniel; Dijkstra, Katinka

    2010-01-01

    Can simple motor actions affect how efficiently people retrieve emotional memories, and influence what they choose to remember? In Experiment 1, participants were prompted to retell autobiographical memories with either positive or negative valence, while moving marbles either upward or downward. They retrieved memories faster when the direction…

  6. Determinantes del ingreso y del gasto corriente de los hogares

    OpenAIRE

    Muñoz C., Manuel

    2004-01-01

    Este ensayo de investigación empírica analiza los determinantes del ingreso y del gasto en los hogares colombianos. Utilizando un modelo del ciclo de vida con datos de la encuesta de hogares de 1994 y 1995, muestra que el comportamiento del ingreso está afectado principalmente por las características demográficas del hogar y los rasgos socio ocupacionales de sus miembros. El comportamiento del gasto está determinado ante todo por el ingreso y, en menor medida, por las características sociales...

  7. Las fluctuaciones del nivel del mar durante el Cuaternario

    OpenAIRE

    Pousa, Jorge Lorenzo; Isla, Federico Ignacio; Schnack, Enrique Jorge

    2002-01-01

    Los cambios del nivel del mar han ejercido una fuerte influencia en la evolución del planeta y en la historia de la humanidad. En una escala de tiempo geológico, las variaciones de los niveles oceánicos han dejado un registro ampliamente distribuido en la forma de depósitos sedimentarios. El descenso del nivel del mar durante la Ultima Glaciación, que alcanzó unos 120 metros hace 18.000 años, permitió la emergencia del estrecho de Bering y la migración humana desde Eurasia hacia América. Se e...

  8. Memory and Oblivion. Testimonies and Depictions

    Directory of Open Access Journals (Sweden)

    Meyer, Eugenia

    2012-05-01

    Full Text Available If everything is history, then, in his work, the historian acknowledges both memory and oblivion when creating those depictions that constitute his never-ending commitment, and hence assumes the responsibility of creating and preserving new sources for a new history. Recovering memory and combating oblivion signify a challenge to ceaselessly denounce injustices. One endeavors to write a history that recovers and preserves different versions of the facts, seen from the most diverse viewpoints and in the light of all manner of interests, and this implies carrying out a task that precedes that of deconstruction, so as to subsequently embark on the heroic feat of splitting hairs, while taking into account different opinions and viewpoints that express the events themselves in many ways. In short, the historian is both a witness of -and a protagonist in- his times.

    Si todo es historia, el oficio de historiar reconoce tanto la memoria como el olvido en la construcción de representaciones que se signifiquen como compromiso permanente del historiador. En consecuencia, asume la responsabilidad de generar y salvaguardar nuevas fuentes para una nueva historia. Recuperar la memoria y luchar en contra del olvido presuponen un desafío que se significa como denuncia permanente. Se intenta una historia que recupere y salvaguarde las diferentes versiones de los hechos, desde las ópticas e intereses más diversos. Ello conlleva una tarea previa de deconstrucción, para luego dar paso a la hazaña de hilar fino, atendiendo a voces y miradas diversas que expresan en formas múltiples el propio acontecer. A fin de cuentas, el historiador como testigo y protagonista de su tiempo.

  9. La imagen del pase.

    Directory of Open Access Journals (Sweden)

    Hernando Bernal.

    1999-11-01

    Full Text Available A partir de un texto del poeta Octavio Paz llamado «La imagen», se busca proseguir la equivalencia entre las imágenes de la poesía y la función que ellas tienen para el poeta, y el fantasma fundamental y su función para el analizante que está en el momento del pase. Se parte de la idea de que la poesía busca entrar en el ser así como el psicoanálisis tiene como finalidad apuntar al corazón del ser del sujeto. Se hace entonces una distinción del concepto de «ser» para el psicoanálisis, haciendo alusión también al discurso de la filosofía. Esclarecido el sentido de lo que es el «ser» para el psicoanálisis, se aborda de lleno – entre otras cosas, relacionadas con la experiencia del pase específicamente- la equivalencia entre la definición que hace Octavio Paz de «La Imagen» y el momento del pase en el análisis de un sujeto, imagen que, al igual que el mito para la filosofía, las leyes para la ciencia y el matema para el psicoanálisis, se constituyen en los instrumentos con los que cada una de estas disciplinas horadan en lo real.

  10. Memory blindness: Altered memory reports lead to distortion in eyewitness memory.

    Science.gov (United States)

    Cochran, Kevin J; Greenspan, Rachel L; Bogart, Daniel F; Loftus, Elizabeth F

    2016-07-01

    Choice blindness refers to the finding that people can often be misled about their own self-reported choices. However, little research has investigated the more long-term effects of choice blindness. We examined whether people would detect alterations to their own memory reports, and whether such alterations could influence participants' memories. Participants viewed slideshows depicting crimes, and then either reported their memories for episodic details of the event (Exp. 1) or identified a suspect from a lineup (Exp. 2). Then we exposed participants to manipulated versions of their memory reports, and later tested their memories a second time. The results indicated that the majority of participants failed to detect the misinformation, and that exposing witnesses to misleading versions of their own memory reports caused their memories to change to be consistent with those reports. These experiments have implications for eyewitness memory.

  11. Exploring memory hierarchy design with emerging memory technologies

    CERN Document Server

    Sun, Guangyu

    2014-01-01

    This book equips readers with tools for computer architecture of high performance, low power, and high reliability memory hierarchy in computer systems based on emerging memory technologies, such as STTRAM, PCM, FBDRAM, etc.  The techniques described offer advantages of high density, near-zero static power, and immunity to soft errors, which have the potential of overcoming the “memory wall.”  The authors discuss memory design from various perspectives: emerging memory technologies are employed in the memory hierarchy with novel architecture modification;  hybrid memory structure is introduced to leverage advantages from multiple memory technologies; an analytical model named “Moguls” is introduced to explore quantitatively the optimization design of a memory hierarchy; finally, the vulnerability of the CMPs to radiation-based soft errors is improved by replacing different levels of on-chip memory with STT-RAMs.   ·         Provides a holistic study of using emerging memory technologies i...

  12. Mediated Cultural Memories

    DEFF Research Database (Denmark)

    Frølunde, Lisbeth; Bjerregaard, Mette

    2013-01-01

    generations. Acts of mass violence also construct a sort of looking glass of culturally dominant memories that are mediated through stories: retold as oral stories through generations, as myths or sagas, or remediated in contemporary documentary or fiction films. In these processes of retelling acts...

  13. Wolfgang Gentner Memorial

    CERN Multimedia

    CERN PhotoLab

    1981-01-01

    The Memorial was held in the Main Auditorium on 30 April 1981. The photo shows (centre, first row) Volker Soergel (DESY Director), Mrs. Gentner, Jean Teillac (President of the Council), Hélène Langevin-Joliot, Herwig Schopper (CERN Director-General).

  14. The Memory of God

    DEFF Research Database (Denmark)

    Rasmussen, Ulrik Houlind

    The thematic aim of the present dissertation is twofold: To contribute to the contemporary discussion within philosophy of religion, which revolves around ‘the death and (alleged) return of God’; more specifically, I want to rethink God through the concept memory, drawing on selected writings from...

  15. The Memory Library

    DEFF Research Database (Denmark)

    Olesen-Bagneux, Ole

    2014-01-01

    of classification and retrieval processes is presented. The key element is to understand the library both as a physical structure and as a structure in the memory of the Alexandrian scholars. In this article, these structures are put together so to propose a new interpretation of the library....

  16. Retrieval from semantic memory.

    NARCIS (Netherlands)

    Noordman-Vonk, Wietske

    1977-01-01

    The present study has been concerned with the retrieval of semantic information. Retrieving semantic information is a fundamental process in almost any kind of cognitive behavior. The introduction presented the main experimental paradigms and results found in the literature on semantic memory as

  17. Echoic memory in pigeons

    NARCIS (Netherlands)

    Kretzschmar, C.; Kalenscher, T.; Güntürkün, O.; Kaernbach, C.

    2008-01-01

    It is unknown whether birds are able to retain the memory of purely sensory auditory information such as white noise over an extended period of time. In a Pavlovian heart rate conditioning paradigm, four pigeons were trained to associate a mild electric shock with periodic random waveforms, and no

  18. Does Echoic Memory Develop?

    Science.gov (United States)

    Engle, Randall W.; And Others

    1981-01-01

    To examine developmental aspects of auditory sensory memory, a series of experiments was conducted on the stimulus suffix effect with the primary variables being age of subject (7 and 11 years), rates of presentation, and length of list. Effects were nearly identical across age groups when a fast presentation rate was used. (Author/DB)

  19. Memory Loss and Retrieval

    Science.gov (United States)

    Reid, Ian

    2016-01-01

    Underlying the generally oblivious attitude of teachers and learners towards the past is insufficient respect for the role of memory in giving meaning to experience and access to knowledge. We shape our identity by making sense of our past and its relationship to present and future selves, a process that should be intensively cultivated when we…

  20. Dreams Memories & Photography

    Science.gov (United States)

    Young, Bernard

    2012-01-01

    Photography students spend a considerable amount of time working on technical issues in shooting, composing, editing, and processing prints. Another aspect of their learning should include the conception and communication of their ideas. A student's memories and dreams can serve as motivation to create images in visual art. Some artists claim that…

  1. [Memory Checking Tests].

    Science.gov (United States)

    Hart, Joseph T.

    Two basic tests for checking memory skills are included in these appendices. The first, the General Information Test, uses the same 150 items for each of its two versions. One version is a completion-type test which measures recall by requiring the examinee to supply a specific response. The other version supplements each of the 150 items with…

  2. History, Memory and Film

    DEFF Research Database (Denmark)

    Bondebjerg, Ib

    In this paper I discuss history and memory from a theoretical and philosophical point of view and the non-fiction and fiction aspects of historical representation. I use Edgar Reitz’ monumental work Heimat 1-3 (and his recent film Die Andere Heimat) as examples of very different transformative...

  3. Memory Mechanisms in Grasping

    Science.gov (United States)

    Hesse, Constanze; Franz, Volker H.

    2009-01-01

    The availability of visual information influences the execution of goal-directed movements. This is very prominent in memory conditions, where a delay is introduced between stimulus presentation and execution of the movement. The corresponding effects could be due to a decay of the visual information or to different processing mechanisms used for…

  4. Technical memory 1999

    International Nuclear Information System (INIS)

    2000-01-01

    The technical memory 1999 of the Nuclear Regulatory Authority (NRA) of the Argentine Republic, compile the papers published in the subject on radiation protection and nuclear safety, safeguards and physical protection, and presented in congress or meetings of these specialities by personnel of the mentioned institution during 1999

  5. Radiation Tolerant Embedded Memory

    National Research Council Canada - National Science Library

    Smith, Brian

    2003-01-01

    ... event effects, and will scale to smaller geometries to provide the same performance. we then designed arrays of that memory to build up blocks to be used in complex Cool-RAD(tm) parts such as microprocessors and digital signal processors.

  6. Measuring Infant Memory.

    Science.gov (United States)

    Bogartz, Richard S.

    1996-01-01

    Reviews three response rate measures (in a baseline measurement, immediately after acquisition, and at a long-term retention test) of infant memory that are used in experiments involving infants' conditioned kicking. Compares these measures to a new measure, the fraction of kicking rate remaining after the retention interval. Explains the…

  7. THE MEMORY OF JUDGMENT:

    African Journals Online (AJOL)

    eliasn

    Lawrence Douglas' book1, The Memory of Judgment: Making Law and History ... film that is not amenable to cross-examination— in a manner that advances his ... willed by more, and tolerated by all”.7 Although the height of the war .... forum that assists in the assessment of the question of guilt or innocence in an.

  8. Quantifiers and working memory

    NARCIS (Netherlands)

    Szymanik, J.; Zajenkowski, M.

    2010-01-01

    The paper presents a study examining the role of working memory in quantifier verification. We created situations similar to the span task to compare numerical quantifiers of low and high rank, parity quantifiers and proportional quantifiers. The results enrich and support the data obtained

  9. Quantifiers and working memory

    NARCIS (Netherlands)

    Szymanik, J.; Zajenkowski, M.

    2009-01-01

    The paper presents a study examining the role of working memory in quantifier verification. We created situations similar to the span task to compare numerical quantifiers of low and high rank, parity quantifiers and proportional quantifiers. The results enrich and support the data obtained

  10. False memories in highly superior autobiographical memory individuals

    Science.gov (United States)

    Patihis, Lawrence; Frenda, Steven J.; LePort, Aurora K. R.; Petersen, Nicole; Nichols, Rebecca M.; Stark, Craig E. L.; McGaugh, James L.; Loftus, Elizabeth F.

    2013-01-01

    The recent identification of highly superior autobiographical memory (HSAM) raised the possibility that there may be individuals who are immune to memory distortions. We measured HSAM participants’ and age- and sex-matched controls’ susceptibility to false memories using several research paradigms. HSAM participants and controls were both susceptible to false recognition of nonpresented critical lure words in an associative word-list task. In a misinformation task, HSAM participants showed higher overall false memory compared with that of controls for details in a photographic slideshow. HSAM participants were equally as likely as controls to mistakenly report they had seen nonexistent footage of a plane crash. Finding false memories in a superior-memory group suggests that malleable reconstructive mechanisms may be fundamental to episodic remembering. Paradoxically, HSAM individuals may retrieve abundant and accurate autobiographical memories using fallible reconstructive processes. PMID:24248358

  11. False memories and memory confidence in borderline patients.

    Science.gov (United States)

    Schilling, Lisa; Wingenfeld, Katja; Spitzer, Carsten; Nagel, Matthias; Moritz, Steffen

    2013-12-01

    Mixed results have been obtained regarding memory in patients with borderline personality disorder (BPD). Prior reports and anecdotal evidence suggests that patients with BPD are prone to false memories but this assumption has to been put to firm empirical test, yet. Memory accuracy and confidence was assessed in 20 BPD patients and 22 healthy controls using a visual variant of the false memory (Deese-Roediger-McDermott) paradigm which involved a negative and a positive-valenced picture. Groups did not differ regarding veridical item recognition. Importantly, patients did not display more false memories than controls. At trend level, borderline patients rated more items as new with high confidence compared to healthy controls. The results tentatively suggest that borderline patients show uncompromised visual memory functions and display no increased susceptibility for distorted memories. Copyright © 2013 Elsevier Ltd. All rights reserved.

  12. Working memory affects false memory production for emotional events.

    Science.gov (United States)

    Mirandola, Chiara; Toffalini, Enrico; Ciriello, Alfonso; Cornoldi, Cesare

    2017-01-01

    Whereas a link between working memory (WM) and memory distortions has been demonstrated, its influence on emotional false memories is unclear. In two experiments, a verbal WM task and a false memory paradigm for negative, positive or neutral events were employed. In Experiment 1, we investigated individual differences in verbal WM and found that the interaction between valence and WM predicted false recognition, with negative and positive material protecting high WM individuals against false remembering; the beneficial effect of negative material disappeared in low WM participants. In Experiment 2, we lowered the WM capacity of half of the participants with a double task request, which led to an overall increase in false memories; furthermore, consistent with Experiment 1, the increase in negative false memories was larger than that of neutral or positive ones. It is concluded that WM plays a critical role in determining false memory production, specifically influencing the processing of negative material.

  13. Mutation of Dcdc2 in mice leads to impairments in auditory processing and memory ability.

    Science.gov (United States)

    Truong, D T; Che, A; Rendall, A R; Szalkowski, C E; LoTurco, J J; Galaburda, A M; Holly Fitch, R

    2014-11-01

    Dyslexia is a complex neurodevelopmental disorder characterized by impaired reading ability despite normal intellect, and is associated with specific difficulties in phonological and rapid auditory processing (RAP), visual attention and working memory. Genetic variants in Doublecortin domain-containing protein 2 (DCDC2) have been associated with dyslexia, impairments in phonological processing and in short-term/working memory. The purpose of this study was to determine whether sensory and behavioral impairments can result directly from mutation of the Dcdc2 gene in mice. Several behavioral tasks, including a modified pre-pulse inhibition paradigm (to examine auditory processing), a 4/8 radial arm maze (to assess/dissociate working vs. reference memory) and rotarod (to examine sensorimotor ability and motor learning), were used to assess the effects of Dcdc2 mutation. Behavioral results revealed deficits in RAP, working memory and reference memory in Dcdc2(del2/del2) mice when compared with matched wild types. Current findings parallel clinical research linking genetic variants of DCDC2 with specific impairments of phonological processing and memory ability. © 2014 John Wiley & Sons Ltd and International Behavioural and Neural Genetics Society.

  14. About Sleep's Role in Memory

    Science.gov (United States)

    2013-01-01

    Over more than a century of research has established the fact that sleep benefits the retention of memory. In this review we aim to comprehensively cover the field of “sleep and memory” research by providing a historical perspective on concepts and a discussion of more recent key findings. Whereas initial theories posed a passive role for sleep enhancing memories by protecting them from interfering stimuli, current theories highlight an active role for sleep in which memories undergo a process of system consolidation during sleep. Whereas older research concentrated on the role of rapid-eye-movement (REM) sleep, recent work has revealed the importance of slow-wave sleep (SWS) for memory consolidation and also enlightened some of the underlying electrophysiological, neurochemical, and genetic mechanisms, as well as developmental aspects in these processes. Specifically, newer findings characterize sleep as a brain state optimizing memory consolidation, in opposition to the waking brain being optimized for encoding of memories. Consolidation originates from reactivation of recently encoded neuronal memory representations, which occur during SWS and transform respective representations for integration into long-term memory. Ensuing REM sleep may stabilize transformed memories. While elaborated with respect to hippocampus-dependent memories, the concept of an active redistribution of memory representations from networks serving as temporary store into long-term stores might hold also for non-hippocampus-dependent memory, and even for nonneuronal, i.e., immunological memories, giving rise to the idea that the offline consolidation of memory during sleep represents a principle of long-term memory formation established in quite different physiological systems. PMID:23589831

  15. A comparison of three types of autobiographical memories in old-old age: first memories, pivotal memories and traumatic memories.

    Science.gov (United States)

    Cohen-Mansfield, Jiska; Shmotkin, Dov; Eyal, Nitza; Reichental, Yael; Hazan, Haim

    2010-01-01

    Autobiographical memory enables us to construct a personal narrative through which we identify ourselves. Especially important are memories of formative events. This study describes autobiographical memories of people who have reached old-old age (85 years and above), studying 3 types of memories of particular impact on identity and adaptation: first memories, pivotal memories and traumatic memories. In this paper, we examine the content, characteristic themes and environments, and structural characteristics of each of the 3 types of memory. The participants were 26 persons from a larger longitudinal study with an average age of 91 years; half were men and the other half women. The study integrated qualitative and quantitative tools. An open-ended questionnaire included questions about the participants' life story as well as questions about the 3 types of memories. The responses were rated by 3 independent judges on dimensions of central themes and structural characteristics. First memories had a more positive emotional tone, more references to characters from the participant's social circle, a stronger sense of group belonging, and a more narrative style than the other types of memories. Pivotal and traumatic memories were described as more personal than first memories. The 3 types of memories reflect different stages in life development, which together form a sense of identity. They present experiences from the past on select themes, which may assist in the complex task of coping with the difficulties and limitations that advanced old age presents. Future research should examine the functional role of those memories and whether they enable the old-old to support selfhood in the challenging period of last changes and losses. Copyright © 2010 S. Karger AG, Basel.

  16. Delirium in advanced age and dementia: A prolonged refractory course of delirium and lower functional status

    Science.gov (United States)

    BOETTGER, SOENKE; JENEWEIN, JOSEF; BREITBART, WILLIAM

    2017-01-01

    Objective The factors associated with persistent delirium, in contrast to resolved delirium, have not been studied well. The aim of our present study was to identify the factors associated with delirium resolution as measured by the Memorial Delirium Assessment Scale (MDAS) and functional improvement as measured by the Karnofsky Performance Status (KPS) scale. Method All subjects were recruited from psychiatric referrals at the Memorial Sloan Kettering Cancer Center (MSKCC). The two study instruments were performed at baseline (T1), at 2–3 days (T2), and at 4–7 days (T3). Subjects with persistent delirium were compared to those with resolved delirium in respect to sociodemographic and medical variables. Results Overall, 26 out of 111 patients had persistent delirium. These patients were older, predominantly male, and had more frequently preexisting comorbid dementia. Among cancer diagnoses and stage of illness, brain cancer and terminal illness contributed to persistent delirium or late response, whereas gastrointestinal cancer was associated with resolved delirium. Among etiologies, infection responded late to delirium management, usually at one week. Furthermore, delirium was more severe in patients with persistent delirium from baseline through one week. At baseline, MDAS scores were 20.1 in persistent delirium compared to 17 to 18.8 in resolved delirium (T2 and T3), and at one week of management (T3), MDAS scores were 15.2 and 4.7 to 7.4, respectively. At one week of management, persistent delirium manifested in more severe impairment in the domains of consciousness, cognition, organization, perception, psychomotor behavior, and sleep–wake cycle. In addition, persistent delirium caused more severe functional impairment. Significance of results In this delirium sample, advanced age and preexisting dementia, as well as brain cancer, terminal illness, infection, and delirium severity contributed to persistent delirium or late response, indicating a prolonged

  17. Milestoning with transition memory

    Science.gov (United States)

    Hawk, Alexander T.; Makarov, Dmitrii E.

    2011-12-01

    Milestoning is a method used to calculate the kinetics and thermodynamics of molecular processes occurring on time scales that are not accessible to brute force molecular dynamics (MD). In milestoning, the conformation space of the system is sectioned by hypersurfaces (milestones), an ensemble of trajectories is initialized on each milestone, and MD simulations are performed to calculate transitions between milestones. The transition probabilities and transition time distributions are then used to model the dynamics of the system with a Markov renewal process, wherein a long trajectory of the system is approximated as a succession of independent transitions between milestones. This approximation is justified if the transition probabilities and transition times are statistically independent. In practice, this amounts to a requirement that milestones are spaced such that trajectories lose position and velocity memory between subsequent transitions. Unfortunately, limiting the number of milestones limits both the resolution at which a system's properties can be analyzed, and the computational speedup achieved by the method. We propose a generalized milestoning procedure, milestoning with transition memory (MTM), which accounts for memory of previous transitions made by the system. When a reaction coordinate is used to define the milestones, the MTM procedure can be carried out at no significant additional expense as compared to conventional milestoning. To test MTM, we have applied its version that allows for the memory of the previous step to the toy model of a polymer chain undergoing Langevin dynamics in solution. We have computed the mean first passage time for the chain to attain a cyclic conformation and found that the number of milestones that can be used, without incurring significant errors in the first passage time is at least 8 times that permitted by conventional milestoning. We further demonstrate that, unlike conventional milestoning, MTM permits

  18. del Estado Aragua

    Directory of Open Access Journals (Sweden)

    Joselys Cintia Zerpa

    2008-01-01

    Full Text Available Diagnostica la situación actual de los bienes que conforman al patrimonio histórico-cultural del Municipio Zamora, Estado Aragua, Venezuela. La Investigación es descriptiva y de campo, comprendió la elaboración de un inventario de los bienes inmuebles, festividades religiosas y manifestaciones artesanales del municipio. Se estudiaron la condición física y uso actual de estos bienes y los planes y proyectos existentes. Analizó el marco normativo que los rige. Se obtuvo la opinión de los representantes de organismos públicos relacionados con la actividad turística del Municipio, de los visitantes, cronistas e historiadores. Aportes: La mayoría de los bienes se encuentran en buen estado de conservación, Las manifestaciones culturales, festividades y la artesanía se desarrollan periódicamente pero no son aprovechadas turísticamente, Se determinó que existe un marco normativo para tales bienes y No existen propuestas actuales referentes a estos bienes. Se reflejó el interés de los sectores institucional y privado para la incorporación de estos bienes a la oferta turística del Municipio y del Estado

  19. APOSTILLAS ACERCA DEL POSTRABAJO

    Directory of Open Access Journals (Sweden)

    Arturo Torrecilla

    2000-01-01

    Full Text Available El más reciente debate en torno al postrabajo transforma la herencia de los dos ciclos que le precedieron desde los años setenta. El primero se correspondía con la crítica de la división social y técnica de labores informada por una filosofía de la alienación o bien por una rectificación de la arquitectónica marxista pero salvaguardando la promesa laborista del buen trabajo. El segundo ciclo hacía eco del rechazo a las cadenas de montaje fordistas y se abría al horizonte de la abolición del trabajo salarial, manteniendo sin embargo el abolengo del sujeto unitario de la historia. La presente escena asume una densidad mayor, producto del encuentro entre las nuevas tecnologías informacionales, las discusiones en el ámbito de la sociología y la antropología, de la tecnología y la ciencia, junto al dueto que inaugura el posmodernismo.

  20. Apostillas acerca del postrabajo

    Directory of Open Access Journals (Sweden)

    Arturo Torrecilla

    2000-04-01

    Full Text Available El más reciente debate en torno al postrabajo transforma la herencia de los dos ciclos que le precedieron desde los años setenta. El primero se correspondía con la crítica de la división social y técnica de labores informada por una filosofía de la alienación o bien por una rectificación de la arquitectónica marxista pero salvaguardando la promesa laborista del buen trabajo. El segundo ciclo hacía eco del rechazo a las cadenas de montaje fordistas y se abría al horizonte de la abolición del trabajo salarial, manteniendo sin embargo el abolengo del sujeto unitario de la historia. La presente escena asume una densidad mayor, producto del encuentro entre las nuevas tecnologías informacionales, las discusiones en el ámbito de la sociología y la antropología, de la tecnología y la ciencia, junto al dueto que inaugura el posmodernismo.

  1. La universidad del futuro

    Directory of Open Access Journals (Sweden)

    FERNANDO SANCÉN CONTRERAS

    2013-01-01

    Full Text Available El trabajo señala la necesidad de reconstruir la Universidad, dado el dinamismo que muestra la ciencia y la sociedad, pues trae consigo cambios sustanciales en la visión del mundo y en el aumento del poder del hombre sobre la naturaleza. Se analizan los supuestos epistemológicos de la universidad tradicional y se propone una nueva explicación del conocimiento humano, enfatizando el conocimiento científico. Postula una docencia fundada en las propiedades de la ciencia, cuyo método inductivo basado en los paradigmas vigentes: analítico, crítico, pragmático, ofrece una herramienta para la docencia, la investigación y la difusión de la cultura. Se propone una educación centrada en el sujeto que se hace a sí mismo (etopoiética y que insiste en el proceso de auto-creación del individuo y de la sociedad.

  2. Significado presente del CSIC

    Directory of Open Access Journals (Sweden)

    Garrido Gallardo, Miguel Angel

    2000-05-01

    Full Text Available Not available

    Este artículo, elaborado en 1999, ofrece una panorámica de la realidad del Consejo Superior de Investigaciones Científicas en la actualidad. Repasa su organización, su volumen de publicaciones, sus indicadores de productividad, su capacidad de obtener recursos y, en suma, su lugar en el conjunto del sistema español de Ciencia y Tecnología, considerado en sí mismo y en relación con la Universidad. Como conclusión del repaso de datos, se afirma que, aunque la fórmula del CSIC, como organismo nacional e interdisciplinario, no es la única posible, la organización del Estado de las Autonomías, así como la evaluación de los datos con que se cuenta, la hacen vivamente recomendable. No hay, pues, sino que seguir con su desarrollo.

  3. Dalt del tren

    Directory of Open Access Journals (Sweden)

    Jaume Subirana

    2001-11-01

    Full Text Available Ens consta que la saviesa popular hi toca més del que a aquest temps d’enquestes, telèfons mòbils i targetes de crèdit li ve de gust admetre, per això em fa gràcia, en veure la pausada però continuada intrusió de la cultura catalana a Internet, recordar les cançons de quan era petit: “Dalt del tren, tots anem-hi dalt del tren, hi ha lloc per tota la gent”, dèiem, i “El tren pinxo de Banyoles és el més bonic que hi ha, ple de llaunes i cassoles i barrets de capellà”. I resulta que per una vegada a la vida hem pujat, efectivament, dalt del tren que passava per l’estació de Catalunya i en cinc anys hem passat de gairebé res a prou pàgines amb un contingut, a més, apreciable i, sobretot, a un petit teixit de persones i institucions que han entès la importància de la revolució comunicativa que Internet representa i que hi teixeixen i projecten webs amb el convenciment dels conversos.

  4. Las carreras del futuro

    Directory of Open Access Journals (Sweden)

    Luis Piscoya Hermoza

    2011-07-01

    Full Text Available La primera década del siglo XXI ha estado signada por un énfasis en los estudiosde prospectiva, los mismos que, a partir de procesos de complejizacióny articulación de la sociedad planetaria como son la digitalización, el progresivodeterioro del medio ambiente, la necesidad del cambio de la matriz energéticay la globalización del mercado, han ensayado hipótesis para identificar lastendencias que se fortalecerán y profundizarán durante las próximas décadas.Desde el punto de vista metodológico, existen muchas maneras de clasificarlaspara conceptualizarlas y entenderlas mejor. Sin embargo, considerando lanaturaleza de esta edición nos proponemos enfocar directamente aquellas queestán estrechamente ligadas a la formación universitaria.Naturalmente, no pensamos que estamos ante tendencias inevitables en lamedida que epistemológicamente la creencia en leyes históricas deterministases insostenible y la práctica social nos muestra que la construcción del futuroes nuestra responsabilidad y siempre rebasa las mejores previsiones.

  5. High-bandwidth memory interface

    CERN Document Server

    Kim, Chulwoo; Song, Junyoung

    2014-01-01

    This book provides an overview of recent advances in memory interface design at both the architecture and circuit levels. Coverage includes signal integrity and testing, TSV interface, high-speed serial interface including equalization, ODT, pre-emphasis, wide I/O interface including crosstalk, skew cancellation, and clock generation and distribution. Trends for further bandwidth enhancement are also covered.   • Enables readers with minimal background in memory design to understand the basics of high-bandwidth memory interface design; • Presents state-of-the-art techniques for memory interface design; • Covers memory interface design at both the circuit level and system architecture level.

  6. Body memories in dance improvisation

    DEFF Research Database (Denmark)

    Ravn, Susanne

    In the analysis of body-memory and improvisation presented in this paper I contend that dancers’ specialised body-memory are not to be understood as more or less automatized. Rather, in each repetition, body-memories – or habits – are to be understood as unfolding in response to the actual context....... The repetition instantiates a fresh memory of these habits while moulding them at the same time. Accordingly, any movement performed is always improvised in different degrees. Throughout the analysis I draw on resent phenomenological discussions to describe how body-memories unfold and find their form...

  7. Memory of titoism: Hegemony frameworks

    Directory of Open Access Journals (Sweden)

    Kuljić Todor

    2010-01-01

    Full Text Available The paper discusses today’s hegemony memory of titoism. The article presents the different reductions in the actually domestic memory culture which are connected with the demonisation and negative symbolisation of titoism. It was broader discussed diffent myths and ideologisations, the factors of a selective memory and a new context in the memory of titoism. Here are outlined the privatisation and the retraditionalisation as the main factors in the maintaing of a new frameworks for the memory of socialism and in the negative symbolisation of titoism.

  8. Neuropsychology and Advances in Memory Function

    Directory of Open Access Journals (Sweden)

    B. Gordon

    1997-01-01

    Full Text Available Recent developments in the functional and neural bases of several aspects of memory are described including long term cortical memory storage, the transition from immediate to permanent memory mediated by medial temporal structures, working memory, memory retrieval, and implicit memory. These are linked to current data on the nature of anterograde and retrograde amnesia in the degenerative diseases, and also to issues in the clinical diagnosis of memory impairments. Understanding the bases of memory can inform the diagnosis of memory impairments in degenerative diseases, and the patterns of impairment seen in the degenerative diseases can help contribute to knowledge of the mechanisms of normal memory.

  9. Topological Schemas of Memory Spaces

    Science.gov (United States)

    Babichev, Andrey; Dabaghian, Yuri A.

    2018-01-01

    Hippocampal cognitive map—a neuronal representation of the spatial environment—is widely discussed in the computational neuroscience literature for decades. However, more recent studies point out that hippocampus plays a major role in producing yet another cognitive framework—the memory space—that incorporates not only spatial, but also non-spatial memories. Unlike the cognitive maps, the memory spaces, broadly understood as “networks of interconnections among the representations of events,” have not yet been studied from a theoretical perspective. Here we propose a mathematical approach that allows modeling memory spaces constructively, as epiphenomena of neuronal spiking activity and thus to interlink several important notions of cognitive neurophysiology. First, we suggest that memory spaces have a topological nature—a hypothesis that allows treating both spatial and non-spatial aspects of hippocampal function on equal footing. We then model the hippocampal memory spaces in different environments and demonstrate that the resulting constructions naturally incorporate the corresponding cognitive maps and provide a wider context for interpreting spatial information. Lastly, we propose a formal description of the memory consolidation process that connects memory spaces to the Morris' cognitive schemas-heuristic representations of the acquired memories, used to explain the dynamics of learning and memory consolidation in a given environment. The proposed approach allows evaluating these constructs as the most compact representations of the memory space's structure. PMID:29740306

  10. Progress In Optical Memory Technology

    Science.gov (United States)

    Tsunoda, Yoshito

    1987-01-01

    More than 20 years have passed since the concept of optical memory was first proposed in 1966. Since then considerable progress has been made in this area together with the creation of completely new markets of optical memory in consumer and computer application areas. The first generation of optical memory was mainly developed with holographic recording technology in late 1960s and early 1970s. Considerable number of developments have been done in both analog and digital memory applications. Unfortunately, these technologies did not meet a chance to be a commercial product. The second generation of optical memory started at the beginning of 1970s with bit by bit recording technology. Read-only type optical memories such as video disks and compact audio disks have extensively investigated. Since laser diodes were first applied to optical video disk read out in 1976, there have been extensive developments of laser diode pick-ups for optical disk memory systems. The third generation of optical memory started in 1978 with bit by bit read/write technology using laser diodes. Developments of recording materials including both write-once and erasable have been actively pursued at several research institutes. These technologies are mainly focused on the optical memory systems for computer application. Such practical applications of optical memory technology has resulted in the creation of such new products as compact audio disks and computer file memories.

  11. Topological Schemas of Memory Spaces

    Directory of Open Access Journals (Sweden)

    Andrey Babichev

    2018-04-01

    Full Text Available Hippocampal cognitive map—a neuronal representation of the spatial environment—is widely discussed in the computational neuroscience literature for decades. However, more recent studies point out that hippocampus plays a major role in producing yet another cognitive framework—the memory space—that incorporates not only spatial, but also non-spatial memories. Unlike the cognitive maps, the memory spaces, broadly understood as “networks of interconnections among the representations of events,” have not yet been studied from a theoretical perspective. Here we propose a mathematical approach that allows modeling memory spaces constructively, as epiphenomena of neuronal spiking activity and thus to interlink several important notions of cognitive neurophysiology. First, we suggest that memory spaces have a topological nature—a hypothesis that allows treating both spatial and non-spatial aspects of hippocampal function on equal footing. We then model the hippocampal memory spaces in different environments and demonstrate that the resulting constructions naturally incorporate the corresponding cognitive maps and provide a wider context for interpreting spatial information. Lastly, we propose a formal description of the memory consolidation process that connects memory spaces to the Morris' cognitive schemas-heuristic representations of the acquired memories, used to explain the dynamics of learning and memory consolidation in a given environment. The proposed approach allows evaluating these constructs as the most compact representations of the memory space's structure.

  12. Olfactory memory traces in Drosophila.

    Science.gov (United States)

    Berry, Jacob; Krause, William C; Davis, Ronald L

    2008-01-01

    In Drosophila, the fruit fly, coincident exposure to an odor and an aversive electric shock can produce robust behavioral memory. This behavioral memory is thought to be regulated by cellular memory traces within the central nervous system of the fly. These molecular, physiological, or structural changes in neurons, induced by pairing odor and shock, regulate behavior by altering the neurons' response to the learned environment. Recently, novel in vivo functional imaging techniques have allowed researchers to observe cellular memory traces in intact animals. These investigations have revealed interesting temporal and spatial dynamics of cellular memory traces. First, a short-term cellular memory trace was discovered that exists in the antennal lobe, an early site of olfactory processing. This trace represents the recruitment of new synaptic activity into the odor representation and forms for only a short period of time just after training. Second, an intermediate-term cellular memory trace was found in the dorsal paired medial neuron, a neuron thought to play a role in stabilizing olfactory memories. Finally, a long-term protein synthesis-dependent cellular memory trace was discovered in the mushroom bodies, a structure long implicated in olfactory learning and memory. Therefore, it appears that aversive olfactory associations are encoded by multiple cellular memory traces that occur in different regions of the brain with different temporal domains.

  13. Atomic memory access hardware implementations

    Science.gov (United States)

    Ahn, Jung Ho; Erez, Mattan; Dally, William J

    2015-02-17

    Atomic memory access requests are handled using a variety of systems and methods. According to one example method, a data-processing circuit having an address-request generator that issues requests to a common memory implements a method of processing the requests using a memory-access intervention circuit coupled between the generator and the common memory. The method identifies a current atomic-memory access request from a plurality of memory access requests. A data set is stored that corresponds to the current atomic-memory access request in a data storage circuit within the intervention circuit. It is determined whether the current atomic-memory access request corresponds to at least one previously-stored atomic-memory access request. In response to determining correspondence, the current request is implemented by retrieving data from the common memory. The data is modified in response to the current request and at least one other access request in the memory-access intervention circuit.

  14. One-way shared memory

    DEFF Research Database (Denmark)

    Schoeberl, Martin

    2018-01-01

    Standard multicore processors use the shared main memory via the on-chip caches for communication between cores. However, this form of communication has two limitations: (1) it is hardly time-predictable and therefore not a good solution for real-time systems and (2) this single shared memory...... is a bottleneck in the system. This paper presents a communication architecture for time-predictable multicore systems where core-local memories are distributed on the chip. A network-on-chip constantly copies data from a sender core-local memory to a receiver core-local memory. As this copying is performed...... in one direction we call this architecture a one-way shared memory. With the use of time-division multiplexing for the memory accesses and the network-on-chip routers we achieve a time-predictable solution where the communication latency and bandwidth can be bounded. An example architecture for a 3...

  15. Constructive memory: past and future.

    Science.gov (United States)

    Schacter, Daniel L

    2012-03-01

    Human memory is not a literal reproduction of the past, but instead relies on constructive processes that are sometimes prone to error and distortion. Understanding of constructive memory has accelerated during recent years as a result of research that has linked together its cognitive and neural bases. This article focuses on three aspects of constructive memory that have been the target of recent research: (i) the idea that certain kinds of memory distortions reflect the operation of adaptive cognitive processes that contribute to the efficient functioning of memory; (ii) the role of a constructive memory system in imagining or simulating possible future events; and (iii) differences between true and false memories that have been revealed by functional neuroimaging techniques. The article delineates the theoretical implications of relevant research, and also considers some clinical and applied implications.

  16. Implicit Memory in Multiple Sclerosis

    Directory of Open Access Journals (Sweden)

    G. Latchford

    1993-01-01

    Full Text Available A number of neuropsychological studies have revealed that memory problems are relatively common in patients with multiple sclerosis (MS. It may be useful to compare MS with conditions such as Huntington's disease (HD, which have been referred to as subcortical dementia. A characteristic of these conditions may be an impairment in implicit (unconscious memory, but not in explicit (conscious memory. The present study examined the functioning of explicit and implicit memory in MS. Results showed that implicit memory was not significantly impaired in the MS subjects, and that they were impaired on recall but not recognition. A correlation was found between implicit memory performance and disability status in MS patients. Findings also suggest the possibility of long-term priming of implicit memory in the control subjects. The implications of these results are discussed.

  17. Olfactory cuing of autobiographical memory.

    Science.gov (United States)

    Rubin, D C; Groth, E; Goldsmith, D J

    1984-01-01

    In Experiment 1, subjects were presented with either the odors or the names of 15 common objects. In Experiment 2, subjects were presented with either the odors, photographs, or names of 16 common objects. All subjects were asked to describe an autobiographical memory evoked by each cue, to date each memory, and to rate each memory on vividness, pleasantness, and the number of times that the memory had been thought of and talked about prior to the experiment. Compared with memories evoked by photographs or names, memories evoked by odors were reported to be thought of and talked about less often prior to the experiment and were more likely to be reported as never having been thought of or talked about prior to the experiment. No other effects were consistently found, though there was a suggestion that odors might evoke more pleasant and emotional memories than other types of cues. The relation of these results to the folklore concerning olfactory cuing is discussed.

  18. Global aspects of radiation memory

    International Nuclear Information System (INIS)

    Winicour, J

    2014-01-01

    Gravitational radiation has a memory effect represented by a net change in the relative positions of test particles. Both the linear and nonlinear sources proposed for this radiation memory are of the ‘electric’ type, or E mode, as characterized by the even parity of the polarization pattern. Although ‘magnetic’ type, or B mode, radiation memory is mathematically possible, no physically realistic source has been identified. There is an electromagnetic counterpart to radiation memory in which the velocity of charged test particles obtain a net ‘kick’. Again, the physically realistic sources of electromagnetic radiation memory that have been identified are of the electric type. In this paper, a global null cone description of the electromagnetic field is applied to establish the non-existence of B-mode radiation memory and the non-existence of E-mode radiation memory due to a bound charge distribution. (paper)

  19. True photographs and false memories.

    Science.gov (United States)

    Lindsay, D Stephen; Hagen, Lisa; Read, J Don; Wade, Kimberley A; Garry, Maryanne

    2004-03-01

    Some trauma-memory-oriented psychotherapists advise clients to review old family photo albums to cue suspected "repressed" memories of childhood sexual abuse. Old photos might cue long-forgotten memories, but when combined with other suggestive influences they might also contribute to false memories. We asked 45 undergraduates to work at remembering three school-related childhood events (two true events provided by parents and one pseudoevent). By random assignment, 23 subjects were also given their school classes' group photos from the years of the to-be-recalled events as memory cues. As predicted, the rate of false-memory reports was dramatically higher in the photo condition than in the no-photo condition. Indeed, the rate of false-memory reports in the photo condition was substantially higher than the rate in any previously published study.

  20. Stress Effects on Working Memory, Explicit Memory, and Implicit Memory for Neutral and Emotional Stimuli in Healthy Men

    OpenAIRE

    Luethi, Mathias; Meier, Beat; Sandi, Carmen

    2009-01-01

    Stress is a strong modulator of memory function. However, memory is not a unitary process and stress seems to exert different effects depending on the memory type under study. Here, we explored the impact of social stress on different aspects of human memory, including tests for explicit memory and working memory (for neutral materials), as well as implicit memory (perceptual priming, contextual priming and classical conditioning for emotional stimuli). A total of 35 young adult...

  1. Componente Cultura del Agua del PMGRH: plan de trabajo

    OpenAIRE

    Autoridad Nacional del Agua; Proyecto de Modernización de la Gestión de Recursos Hídricos

    2012-01-01

    Describe el plan de trabajo del Componente Cultura del Agua del Proyecto de Modernización de la Gestión de Recursos Hídricos (PMGRH) en relacion a dos aspectos estructurales del proyecto: 1. Mejora de la capacidad de la Gestión Integrada de Recursos Hídricos (GIRH) a nivel nacional y 2. Fortalecimiento de las capacidades de GIRH en las cuencas.

  2. En busca del concepto de gerencia del cuidado

    Directory of Open Access Journals (Sweden)

    Ligia Teresa Mora-Delgado

    2005-12-01

    Full Text Available Este articulo, presenta los conceptos de gerencia del cuidado de enfermería, desarrollado por las enfermeras profesionales que laboran en le Empresa social del estado Hospital Universitario Erasmo Meoz de las Ciudad de Cúcuta, desde su desempeño en la asistencia, administración y docencia. Se pretende además precisar los elementos gerenciales, sociales, humanísticos y éticos que deben hacer parte del concepto de gerencia del cuidado.

  3. LA PERSISTENCIA DEL SUBALTERNO

    Directory of Open Access Journals (Sweden)

    John Beverley

    2002-01-01

    Full Text Available Este trabajo es el texto literal de una ponencia presentada en un panel sobre los estudios culturales latinoamericanos en el congreso de LASA en 2001 en Washington DC. Representa la posición desarrollada en el trabajo colectivo del llamado Grupo de Estudios Subalternos Latinoamericano, desde nuestra fundación en 1992 hasta la disolución del grupo en 2001, que sirve como pretexto introductorio para la ponencia. Los otros participantes en el panel eran Walter Mignolo, representando los estudios poscoloniales, Néstor García Canclini y John Kraniauskas, representando los estudios culturales, y Nelly Richard representando la llamada crítica cultural. El trabajo dialoga y debate con cada una de estas posiciones respectivamente desde el punto de vista específico de los estudios subalternos. Concluye con un llamado a una crítica del saber académico en sí.

  4. Acalasia. Controversias del tratamiento

    OpenAIRE

    Restrepo P, Antonio J; Rey T, Mario H; Garzón O, Martín A; Farfán Q, Yesid A; Molano V, Juan C; Marulanda, Juan C; Lizarazo, Jorge I

    2007-01-01

    La acalasia es un desorden motor del esófago caracterizado por pérdida de la peristalsis esofágica con falta en la relajación o relajación incompleta del esfínter esofágico inferior (EEI) (1). La causa exacta de este trastorno es desconocida. Los síntomas más comunes son disfagia, regurgitación, pérdida de peso y dolor torácico (2). La manometría esofágica es el principal método diagnóstico, mostrando aperistalsis del cuerpo esofágico con aumento de la presión, falta de relajación o relajació...

  5. Procedimiento Del Triple Fin

    Directory of Open Access Journals (Sweden)

    Oscar L. Bellido Aguilera

    2008-01-01

    Full Text Available Presenta un procedimiento novedoso basado en un método dialéctico - sistémico - integrador, que facilita la precisión de los fines u objetivos más generales de un proceso de desarrollo comunitario o de otros procesos de cambio deseados (un proyecto sociocultural, una investigación social, un proceso de mejoramiento organizacional, etc.. Su importancia radica en que los fines, según Marx, son una guía que rige como una ley la actuación del hombre y determinarlos es parte esencial del planeamiento del cambio. Se trata de un asunto aparentemente simple, sin embargo, en la práctica es mucho más problemático de lo que comúnmente se cree.

  6. Efecto del silicio y plaguicidas en la fertilidad del suelo y rendimiento del arroz

    OpenAIRE

    Furcal-Beriguete, Parménides; Herrera-Barrantes, Alejandra

    2013-01-01

    Efecto del silicio y plaguicidas en la fertilidad del suelo y rendimiento del arroz. El objetivo de este trabajo fue evaluar el efecto del silicio en la fertilidad del suelo, la incidencia de enfermedades y plagas insectiles, el rendimiento y la calidad de granos del cultivo de arroz. El estudio se realizó en La Vega, Florencia, San Carlos, Costa Rica entre mayo y octubre en los años 2010 y 2011, en el mismo lote con la variedad CR 4477. Se establecieron cinco tratamientos: silicio al suelo, ...

  7. Storia del pensiero matematico

    CERN Document Server

    Kline, Morris

    1999-01-01

    Costruita con l'intento di presentare le idee oltre ai protagonisti della matematica, questa storia ha il duplice pregio dell'esaustività e della chiarezza. Essa prevede infatti vari livelli di lettura: lo specialista vi trova una messe di dati, fonti e spunti di ricerca, mentre lo studente ha a disposizione un formidabile strumento di consultazione e sintesi. L'arco temporale coperto è vasto: dalla Mesopotamia a Euclide, da Fibonacci all'invenzione del calcolo infinitesimale, da Gauss a Poincare, con un'appendice dedicata agli sviluppi piu recenti scritta appositamente per la prima edizione italiana del 1991, nei «Manuali» Einaudi.

  8. La escritura del quechua

    OpenAIRE

    Authier, Martine du

    2015-01-01

    La mayor fantasía ha acompañado siempre la transcripción del quechua. El primer intento de sistematización fue el sistema de la Paz, en 1953. Sin embargo, no existe en el comercio un diccionario satisfactorio en lo que se refiere al quechua del Cusco y, prácticamente, nada se edita en quechua, fuera de algunos trabajos antropológicos bilingües. Bajo la égida de la UNESCO, la Academia Peruana de la Lengua Quechua, que tiene su sede en el Cusco, ha colaborado en un diccionario de doce de los tr...

  9. El lenguaje del cerebro

    Directory of Open Access Journals (Sweden)

    Antonio Ibáñez Molina

    2011-04-01

    Full Text Available La introducción de nuevas técnicas de análisis de ritmos EEG en estudio de la comprensión del lenguaje permite explorar esta habilidad humana desde una perspectiva de integración de grupos de redes neuronales. Los ritmos de disparo neuronal que generan estos grupos pueden conectarse por sincronía formando unidades funcionales transitorias distribuidas en diversas áreas del cerebro. En esta revisión comentamos algunos de estos ritmos y su relación con el lenguaje.

  10. Plasticidad del sistema nervioso

    Directory of Open Access Journals (Sweden)

    L. M. Garcia-Segura

    1976-06-01

    Full Text Available En este trabajo se revisan los conocimientos más recientes sobre el fenómeno de la plasticidad del sistéma nervioso, tanto a nivel morfológico como a nivel fisiológico y molecular. Se estudian los cambios morfólogicos y fisiológicos de las neuronas frente a la experiencia. Tambien se considera la adaptación molecular del sistéma nervioso a la información que recibe como la base de todo tipo de plasticidad.

  11. Las causas del desempleo

    OpenAIRE

    García Balbás, Salomé

    2014-01-01

    En este documento vamos a tratar de dar respuesta a la siguiente pregunta: ¿cuáles son las causas del desempleo? Para ello realizaremos un repaso de las principales teorías económicas del desempleo llegando a la conclusión de que existe una causa fundamental que lo genera: la rigidez de los salarios a la baja. Consideramos el desempleo como la existencia de un exceso de oferta en el mercado de trabajo y haremos alusión, únicamente, a la existencia de desempleo involuntario. La exposición de l...

  12. Inventario del Archivo del conde de Bornos

    Directory of Open Access Journals (Sweden)

    Pedro Antonio Porras Arboledas

    1995-01-01

    Full Text Available Mi primer contacto con esta Casa se remonta a algunos años atrás, cuando me Mamó la atención un documento muy interesante, publicado a comienzos del presente siglo por el ilustre erudito ubetense don Alfredo Cazaban, por el que los Reyes Católicos hacían merced a su secretario y jefe de la artillería real durante la Guerra contra Granada, Francisco Ramírez de Madrid, personaje madrileño de origen cántabro, de una heredad en término de Jaén —el cortijo de Bornos— por sus grandes esfuerzos en la conquista de las plazas, hasta el momento inexpugnables, de Cambil y Alhabar. Posteriormente, al realizar un estudio sobre el régimen señorial en el Reino de Jaén, intenté localizar los archivos de las diferentes casas nobiliarias asentadas en esta provincia, gracias a lo cual pude saber que la documentación del Condado de Bornos se hallaba en Madrid, bien en la Biblioteca Nacional o en el Archivo Histórico, ya que el actual Conde, el Excmo. Sr. Don Ignacio Ramírez de Haro, así me lo comunicó en marzo de 1983.

  13. Reward disrupts reactivated human skill memory

    OpenAIRE

    Dayan, Eran; Laor-Maayany, Rony; Censor, Nitzan

    2016-01-01

    Accumulating evidence across species and memory domains shows that when an existing memory is reactivated, it becomes susceptible to modifications. However, the potential role of reward signals in these mechanisms underlying human memory dynamics is unknown. Leaning on a wealth of findings on the role of reward in reinforcing memory, we tested the impact of reinforcing a skill memory trace with monetary reward following memory reactivation, on strengthening of the memory trace. Reinforcing re...

  14. Bernal Díaz del Castillo, la memoria y la representación

    Directory of Open Access Journals (Sweden)

    María Luisa Fischer

    2016-04-01

    Full Text Available En este trabajo se analizan los procedimientos narrativos que verosimilizan la versión de la historia que define Bernal Díaz del Castillo. Se analiza la función que en el total del relato cumplen los capítulos de largos listados que lo cierran y, especialmente, el capítulo CCVI, dedicado a los retratos indistinguibles de los capitanes españoles de la Nueva España. Se muestra cómo la memoria privilegiada del cronista está funcionando bajo el predicamento de una retórica -en este caso, la del retrato del héroe, de origen medieval- que disputa su lugar frente a la pretendida reconstrucción de la experiencia por la vía única de la memoria. This work analyse the narrative procedures which Bernal Díaz del Castillo uses to make his version of history appear to be probable. The function of the long lists at the end of the story and, especially of Chapter CCVI, containing the indistinguishable portraits of New Spain's Spanish capitains is explained. How the chronicler's privileged memory functions as a rhetorical category -in this case, that of the portrait of a medieval hero- who argues his case for the pretended reconstruction of an experience based only on memory is shown.

  15. Competencia Desarrollo del Pensamiento Creativo

    OpenAIRE

    Rodríguez, Eric; Miceli, Francisco; Tiburcio, Georgina; Gómez, Orlando

    2012-01-01

    1. ¿Qué significa la competencia Desarrollo del Pensamiento Creativo? 2. ¿Por qué es relevante que adquiera la competencia Desarrollo del Pensamiento Creativo en mi formación? 3. ¿Cómo aprendo la competencia Desarrollo del Pensamiento Creativo? 4. ¿Cómo aplico la competencia Desarrollo del Pensamiento Creativo? 5. ¿Cómo puedo autoevaluar mi competencia (con miras a un constante crecimiento)?

  16. Magnetic shape memory behaviour

    International Nuclear Information System (INIS)

    Brown, P.J.; Gandy, A.P.; Ishida, K.; Kainuma, R.; Kanomata, T.; Matsumoto, M.; Morito, H.; Neumann, K.-U.; Oikawa, K.; Ouladdiaf, B.; Ziebeck, K.R.A.

    2007-01-01

    Materials that can be transformed at one temperature T F , then cooled to a lower temperature T M and plastically deformed and on heating to T F regain their original shape are currently receiving considerable attention. In recovering their shape the alloys can produce a displacement or a force, or a combination of the two. Such behaviour is known as the shape memory effect and usually takes place by change of temperature or applied stress. For many applications the transformation is not sufficiently rapid or a change in temperature/pressure not appropriate. As a result, considerable effort is being made to find a ferromagnetic system in which the effect can be controlled by an applied magnetic field. The results of recent experiments on ferromagnetic shape memory compounds aimed at understanding the underlying mechanism will be reviewed

  17. TED KYCIA MEMORIAL SYMPOSIUM.

    Energy Technology Data Exchange (ETDEWEB)

    LITTENBERG, L.; RUBINSTEIN, R.; SAMIOS, N.; LI, K.; GIACOMELLI, G.; MOCKETT, P.; CARROLL, A.; JOHNSON, R.; BRYMAN, D.; TIPPENS, B.

    2000-05-19

    On the afternoon of May 19 2000, a Memorial Seminar was held in the BNL physics Large Seminar Room to honor the memory of Ted Kyeia, a prominent particle physicist who had been a member of the BNL staff for 40 years. Although it was understandably a somewhat sad occasion because Ted was no longer with us, nevertheless there was much for his colleagues and friends to celebrate in recalling the outstanding contributions that he had made in those four decades. The Seminar speakers were all people who had worked with Ted during that period; each discussed one aspect of his career, but also included anecdotes and personal reminiscences. This booklet contains the Seminar program, listing the speakers, and also copies of transparencies of the talks (and one paper which was a later expansion of a talk); sadly, not all of the personal remarks appeared on the transparencies.

  18. Learning, memory, and synesthesia.

    Science.gov (United States)

    Witthoft, Nathan; Winawer, Jonathan

    2013-03-01

    People with color-grapheme synesthesia experience color when viewing written letters or numerals, usually with a particular color evoked by each grapheme. Here, we report on data from 11 color-grapheme synesthetes who had startlingly similar color-grapheme pairings traceable to childhood toys containing colored letters. These are the first and only data to show learned synesthesia of this kind in more than a single individual. Whereas some researchers have focused on genetic and perceptual aspects of synesthesia, our results indicate that a complete explanation of synesthesia must also incorporate a central role for learning and memory. We argue that these two positions can be reconciled by thinking of synesthesia as the automatic retrieval of highly specific mnemonic associations, in which perceptual contents are brought to mind in a manner akin to mental imagery or the perceptual-reinstatement effects found in memory studies.

  19. TED KYCIA MEMORIAL SYMPOSIUM

    International Nuclear Information System (INIS)

    LITTENBERG, L.; RUBINSTEIN, R.; SAMIOS, N.; LI, K.; GIACOMELLI, G.; MOCKETT, P.; CARROLL, A.; JOHNSON, R.; BRYMAN, D.; TIPPENS, B.

    2000-01-01

    On the afternoon of May 19 2000, a Memorial Seminar was held in the BNL physics Large Seminar Room to honor the memory of Ted Kyeia, a prominent particle physicist who had been a member of the BNL staff for 40 years. Although it was understandably a somewhat sad occasion because Ted was no longer with us, nevertheless there was much for his colleagues and friends to celebrate in recalling the outstanding contributions that he had made in those four decades. The Seminar speakers were all people who had worked with Ted during that period; each discussed one aspect of his career, but also included anecdotes and personal reminiscences. This booklet contains the Seminar program, listing the speakers, and also copies of transparencies of the talks (and one paper which was a later expansion of a talk); sadly, not all of the personal remarks appeared on the transparencies

  20. Sparse distributed memory

    Science.gov (United States)

    Denning, Peter J.

    1989-01-01

    Sparse distributed memory was proposed be Pentti Kanerva as a realizable architecture that could store large patterns and retrieve them based on partial matches with patterns representing current sensory inputs. This memory exhibits behaviors, both in theory and in experiment, that resemble those previously unapproached by machines - e.g., rapid recognition of faces or odors, discovery of new connections between seemingly unrelated ideas, continuation of a sequence of events when given a cue from the middle, knowing that one doesn't know, or getting stuck with an answer on the tip of one's tongue. These behaviors are now within reach of machines that can be incorporated into the computing systems of robots capable of seeing, talking, and manipulating. Kanerva's theory is a break with the Western rationalistic tradition, allowing a new interpretation of learning and cognition that respects biology and the mysteries of individual human beings.

  1. Investigating Memory Development in Children and Infantile Amnesia in Adults

    Science.gov (United States)

    Kazemi Tari, Somayeh

    2008-01-01

    Although many researchers have worked on memory development, still little is known about what develops in memory development. When one reviews the literature about memory, she encounters many types of memories such as short term vs. long term memory, working memory, explicit vs. implicit memory, trans-saccadic memory, autobiographical memory,…

  2. Working Memory Systems in the Rat.

    Science.gov (United States)

    Bratch, Alexander; Kann, Spencer; Cain, Joshua A; Wu, Jie-En; Rivera-Reyes, Nilda; Dalecki, Stefan; Arman, Diana; Dunn, Austin; Cooper, Shiloh; Corbin, Hannah E; Doyle, Amanda R; Pizzo, Matthew J; Smith, Alexandra E; Crystal, Jonathon D

    2016-02-08

    A fundamental feature of memory in humans is the ability to simultaneously work with multiple types of information using independent memory systems. Working memory is conceptualized as two independent memory systems under executive control [1, 2]. Although there is a long history of using the term "working memory" to describe short-term memory in animals, it is not known whether multiple, independent memory systems exist in nonhumans. Here, we used two established short-term memory approaches to test the hypothesis that spatial and olfactory memory operate as independent working memory resources in the rat. In the olfactory memory task, rats chose a novel odor from a gradually incrementing set of old odors [3]. In the spatial memory task, rats searched for a depleting food source at multiple locations [4]. We presented rats with information to hold in memory in one domain (e.g., olfactory) while adding a memory load in the other domain (e.g., spatial). Control conditions equated the retention interval delay without adding a second memory load. In a further experiment, we used proactive interference [5-7] in the spatial domain to compromise spatial memory and evaluated the impact of adding an olfactory memory load. Olfactory and spatial memory are resistant to interference from the addition of a memory load in the other domain. Our data suggest that olfactory and spatial memory draw on independent working memory systems in the rat. Copyright © 2016 Elsevier Ltd. All rights reserved.

  3. Sleep loss produces false memories.

    Directory of Open Access Journals (Sweden)

    Susanne Diekelmann

    Full Text Available People sometimes claim with high confidence to remember events that in fact never happened, typically due to strong semantic associations with actually encoded events. Sleep is known to provide optimal neurobiological conditions for consolidation of memories for long-term storage, whereas sleep deprivation acutely impairs retrieval of stored memories. Here, focusing on the role of sleep-related memory processes, we tested whether false memories can be created (a as enduring memory representations due to a consolidation-associated reorganization of new memory representations during post-learning sleep and/or (b as an acute retrieval-related phenomenon induced by sleep deprivation at memory testing. According to the Deese, Roediger, McDermott (DRM false memory paradigm, subjects learned lists of semantically associated words (e.g., "night", "dark", "coal",..., lacking the strongest common associate or theme word (here: "black". Subjects either slept or stayed awake immediately after learning, and they were either sleep deprived or not at recognition testing 9, 33, or 44 hours after learning. Sleep deprivation at retrieval, but not sleep following learning, critically enhanced false memories of theme words. This effect was abolished by caffeine administration prior to retrieval, indicating that adenosinergic mechanisms can contribute to the generation of false memories associated with sleep loss.

  4. Cancer immunotherapy and immunological memory.

    Science.gov (United States)

    Murata, Kenji; Tsukahara, Tomohide; Torigoe, Toshihiko

    2016-01-01

    Human immunological memory is the key distinguishing hallmark of the adaptive immune system and plays an important role in the prevention of morbidity and the severity of infection. The differentiation system of T cell memory has been clarified using mouse models. However, the human T cell memory system has great diversity induced by natural antigens derived from many pathogens and tumor cells throughout life, and profoundly differs from the mouse memory system constructed using artificial antigens and transgenic T cells. We believe that only human studies can elucidate the human immune system. The importance of immunological memory in cancer immunotherapy has been pointed out, and the trafficking properties and long-lasting anti-tumor capacity of memory T cells play a crucial role in the control of malignant tumors. Adoptive cell transfer of less differentiated T cells has consistently demonstrated superior anti-tumor capacity relative to more differentiated T cells. Therefore, a human T cell population with the characteristics of stem cell memory is thought to be attractive for peptide vaccination and adoptive cell transfer. A novel human memory T cell population that we have identified is closer to the naive state than previous memory T cells in the T cell differentiation lineage, and has the characteristics of stem-like chemoresistance. Here we introduce this novel population and describe the fundamentals of immunological memory in cancer immunotherapy.

  5. The evolution of episodic memory

    Science.gov (United States)

    Allen, Timothy A.; Fortin, Norbert J.

    2013-01-01

    One prominent view holds that episodic memory emerged recently in humans and lacks a “(neo)Darwinian evolution” [Tulving E (2002) Annu Rev Psychol 53:1–25]. Here, we review evidence supporting the alternative perspective that episodic memory has a long evolutionary history. We show that fundamental features of episodic memory capacity are present in mammals and birds and that the major brain regions responsible for episodic memory in humans have anatomical and functional homologs in other species. We propose that episodic memory capacity depends on a fundamental neural circuit that is similar across mammalian and avian species, suggesting that protoepisodic memory systems exist across amniotes and, possibly, all vertebrates. The implication is that episodic memory in diverse species may primarily be due to a shared underlying neural ancestry, rather than the result of evolutionary convergence. We also discuss potential advantages that episodic memory may offer, as well as species-specific divergences that have developed on top of the fundamental episodic memory architecture. We conclude by identifying possible time points for the emergence of episodic memory in evolution, to help guide further research in this area. PMID:23754432

  6. A Memorial Gathering

    CERN Multimedia

    2004-01-01

    Bob Dobinson (1943-2004) Bob's friends and colleagues are warmly invited to join in a memorial gathering on Thursday 15th April 2004 at 11:00 hours in the CERN Council Chamber/ Salle de Conseil (Bldg 503 1st floor) Some colleagues will pay tribute to Bob's lifetime achievements and his contributions to past and present experiments. The gathering will conclude with refreshments in the Salle des Pas Perdus.

  7. Segmenting memory colours

    OpenAIRE

    Fredembach, Clément; Estrada, Francisco; Süsstrunk, Sabine

    2008-01-01

    Memory colours refer to the colour of specific image classes that have the essential attribute of being perceived in a consistent manner by human observers. In colour correction or rendering tasks, this consistency implies that they have to be faithfully reproduced; their importance, in that respect, is greater than other regions in an image. Before these regions can be properly addressed, one must in general detect them. There are various schemes and attributes to do so, but the preferred me...

  8. Extending Mondrian Memory Protection

    Science.gov (United States)

    2010-11-01

    a kernel semaphore is locked or unlocked. In addition, we extended the system call interface to receive notifications about user-land locking...operations (such as calls to the mutex and semaphore code provided by the C library). By patching the dynamically loadable GLibC5, we are able to test... semaphores , and spinlocks. RTO-MP-IST-091 10- 9 Extending Mondrian Memory Protection to loading extension plugins. This prevents any untrusted code

  9. Short-term memory

    Science.gov (United States)

    Toulouse, G.

    This is a rather bold attempt to bridge the gap between neuron structure and psychological data. We try to answer the question: Is there a relation between the neuronal connectivity in the human cortex (around 5,000) and the short-term memory capacity (7±2)? Our starting point is the Hopfield model (Hopfield 1982), presented in this volume by D.J. Amit.

  10. Shape memory alloy actuator

    Science.gov (United States)

    Varma, Venugopal K.

    2001-01-01

    An actuator for cycling between first and second positions includes a first shaped memory alloy (SMA) leg, a second SMA leg. At least one heating/cooling device is thermally connected to at least one of the legs, each heating/cooling device capable of simultaneously heating one leg while cooling the other leg. The heating/cooling devices can include thermoelectric and/or thermoionic elements.

  11. Iconic memory of icon?

    OpenAIRE

    Chow, Dr Siu L.

    1987-01-01

    The objectives of the present commentary are to show that (1) one important theoretical property of iconic memory is inconsistent with a retinotopic icon, (2) data difficult for the notion of an icon do not necessarily challenge the notion of an iconic store, (3) the iconic store, as a theoretical mechanism, is an ecologically valid one, and (4) the rationale of experimentation is such that the experimental task need not mimic the phenomenon being studied.

  12. Ruptura del projecte parental i disposició dels preembrions

    OpenAIRE

    Farnós Amorós, Esther

    2010-01-01

    La tesi doctoral "Ruptura del projecte parental i disposició dels preembrions" analitza els efectes del consentiment a les tècniques de reproducció assistida prestat en el marc d'un projecte parental. La tesi ofereix una resposta als conflictes que enfronten exesposos o exconvivents en relació al destí dels preembrions sobrants d'un cicle de fecundació "in vitro" iniciat durant la relació. Aquests conflictes constitueixen un grup de casos al voltant del qual no hi ha solucions legislatives qu...

  13. La equinoterapia en las distintas alteraciones del desarrollo del menor.

    OpenAIRE

    Chamorro González, Mireya

    2015-01-01

    La equinoterapia consiste en la utilización del caballo como un método terapéutico para rehabilitar a personas con discapacidad. Esta terapia es considerada una gran alternativa para aumentar el autoestima de los que sufren algún tipo de discapacidad, también a través de esta terapia se mejora y fortalece el estado emocional, así del mismo modo ayuda a mejorar la manera de desenvolverse en su entorno social. Esta terapia se realiza a través de la trasmisión del calor corporal del caballo, del...

  14. Gestión del riesgo del cambio (segunda parte)

    OpenAIRE

    Zorrilla Salgador, Juan Pablo

    2004-01-01

    Segunda parte del artículo acerca del uso de futuros sobre el tipo de cambio. Esta continuación abarca estrategias, definiciones, metodología y explicaciones sobre todo lo relacionado con el Ratio de cobertura de los futuros y la aparición del riesgo base.Segunda parte del artículo acerca del uso de futuros sobre el tipo de cambio. Esta continuación abarca estrategias, definiciones, metodología y explicaciones sobre todo lo relacionado con el Ratio de cobertura de los futuros y la aparición d...

  15. The Nature of Individual Differences in Working Memory Capacity: Active Maintenance in Primary Memory and Controlled Search from Secondary Memory

    Science.gov (United States)

    Unsworth, Nash; Engle, Randall W.

    2007-01-01

    Studies examining individual differences in working memory capacity have suggested that individuals with low working memory capacities demonstrate impaired performance on a variety of attention and memory tasks compared with individuals with high working memory capacities. This working memory limitation can be conceived of as arising from 2…

  16. Sleep, Memory & Brain Rhythms.

    Science.gov (United States)

    Watson, Brendon O; Buzsáki, György

    2015-01-01

    Sleep occupies roughly one-third of our lives, yet the scientific community is still not entirely clear on its purpose or function. Existing data point most strongly to its role in memory and homeostasis: that sleep helps maintain basic brain functioning via a homeostatic mechanism that loosens connections between overworked synapses, and that sleep helps consolidate and re-form important memories. In this review, we will summarize these theories, but also focus on substantial new information regarding the relation of electrical brain rhythms to sleep. In particular, while REM sleep may contribute to the homeostatic weakening of overactive synapses, a prominent and transient oscillatory rhythm called "sharp-wave ripple" seems to allow for consolidation of behaviorally relevant memories across many structures of the brain. We propose that a theory of sleep involving the division of labor between two states of sleep-REM and non-REM, the latter of which has an abundance of ripple electrical activity-might allow for a fusion of the two main sleep theories. This theory then postulates that sleep performs a combination of consolidation and homeostasis that promotes optimal knowledge retention as well as optimal waking brain function.

  17. False memories in highly superior autobiographical memory individuals

    OpenAIRE

    Patihis, Lawrence; Frenda, Steven J.; LePort, Aurora K. R.; Petersen, Nicole; Nichols, Rebecca M.; Stark, Craig E. L.; McGaugh, James L.; Loftus, Elizabeth F.

    2013-01-01

    The recent identification of highly superior autobiographical memory (HSAM) raised the possibility that there may be individuals who are immune to memory distortions. We measured HSAM participants' and age- and sex-matched controls' susceptibility to false memories using several research paradigms. HSAM participants and controls were both susceptible to false recognition of nonpresented critical lure words in an associative word-list task. In a misinformation task, HSAM participants showed hi...

  18. Memory-guided attention: Control from multiple memory systems

    OpenAIRE

    Hutchinson, J. Benjamin; Turk-Browne, Nicholas B.

    2012-01-01

    Attention is strongly influenced by both external stimuli and internal goals. However, this useful dichotomy does not readily capture the ubiquitous and often automatic contribution of past experience stored in memory. We review recent evidence about how multiple memory systems control attention, consider how such interactions are manifested in the brain, and highlight how this framework for ‘memory-guided attention’ might help systematize previous findings and guide future research.

  19. Dreams are made of memories, but maybe not for memory.

    Science.gov (United States)

    Blagrove, Mark; Ruby, Perrine; Eichenlaub, Jean-Baptiste

    2013-12-01

    Llewellyn's claim that rapid eye movement (REM) dream imagery may be related to the processes involved in memory consolidation during sleep is plausible. However, whereas there is voluntary and deliberate intention behind the construction of images in the ancient art of memory (AAOM) method, there is a lack of intentionality in producing dream images. The memory for dreams is also fragile, and dependent on encoding once awake.

  20. del's Proof

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 12; Issue 5. Gödel's Proof - Incompleteness Theorems. S M Srivastava. General Article Volume 12 Issue 5 May 2007 pp 71-84. Fulltext. Click here to view fulltext PDF. Permanent link: https://www.ias.ac.in/article/fulltext/reso/012/05/0071-0084. Keywords.

  1. Marketing Mix del Software.

    Directory of Open Access Journals (Sweden)

    Yudith del Carmen Rodríguez Pérez

    2006-03-01

    Por ello, en este trabajo se define el concepto de producto software, se caracteriza al mismo y se exponen sus atributos de calidad. Además, se aborda la mezcla de marketing del software necesaria y diferente a la de otros productos para que este triunfe en el mercado.

  2. Gerencia del servicio

    OpenAIRE

    Nancy Peña Acosta

    1992-01-01

    Estamos en la era de la pirámide invertida donde el cliente es primero por lo que es fundamental incentivar la calidad desde abajo; hacer que el trabajador defina su misión, sienta que es parte de la compañía para que la satisfacción del negocio realizado sea de todos.

  3. El Juego del Juego

    OpenAIRE

    Carvalho, Nazaré Cristina

    2012-01-01

    DUVIGNAUD, Jean. El Juego del Juego. Santafé de Bogotá, Colômbia: Fondo de Cultura Econômica, 1997.The game gameDUVIGNAUD, Jean. The Game Game. Santafé de Bogotá, Colombia: Fondo de Cultura Econômica, 1997

  4. El helor del cuerpo

    OpenAIRE

    Sánchez-Biosca, Vicente

    1992-01-01

    Ensayo sobre las formas clásicas y modernas de la metamorfosis. En esta figura mitológica se advierte de manera privilegiada la entrada del imaginario científico, biológico y genético en el dominio de las construcciones literarias y cinematográficas.

  5. Carta del Editor

    Directory of Open Access Journals (Sweden)

    Luis Eladio Proaño

    2014-12-01

    Full Text Available La publicación se centra en temas como: Procesos electorales en México e Italia, se analizan los procesos comunicacionales y sus efectos; las infiltraciones de las agencias de seguridad en la actividad periodística en Europa; la radio y la televisión pública en los EE.UU. Para conocer cómo la prensa enfrenta los problemas críticos entre países, esta el caso de Uruguay y Argentina (discrepancia por la planta de procesamiento de papel y la contaminación del Río de La Plata. Otro artículo refiere la difícil relación entre los medios de comunicación y el gobierno de Chávez en Venezuela. Se aborda el caso brasileño para entender el crecimiento de los Observatorios de Medios; otro sobre el crecimiento del "periodismo confidencial" en la web y la prensa gratuita. Se estudia el impacto de la telenovela "pasión de gavilanes". Para quienes interese la penetración del Internet está: "Usos y competencias del weblog en las corporaciones" más otro sobre la lucha sorda que mantienen los gigantes de la autopista de la información Google y Yahoo.

  6. Punctualizaciones del CERN

    CERN Multimedia

    2002-01-01

    "Viene de la pagina anterior. Puntualizaciones del CERN. La valoracion que me merece la aprobacion en el Consejo de Ministros el 24 de mayo de un acuerdo de colaboracion entre el MCYT y el CERN para el proyecto de neutrinos al Gran Sasso es positiva" (1 page).

  7. Software del sistema osteomioarticular

    Directory of Open Access Journals (Sweden)

    Dianelys León Medina

    2015-06-01

    Full Text Available Introducción: la aplicación en la enseñanza de las Tecnologías de la Informática y las Comunicaciones, es una de las líneas que ha trazado el sistema de salud cubano en estudiantes de las ciencias médicas. La anatomía es una de las ciencias que integra la disciplina de Morfofisiología y para facilitar su comprensión resulta necesario el empleo de recursos y estrategias, entre los que puede figurar un software educativo. Objetivo: diseñar un software sobre la anatomía del sistema osteomioarticular de cabeza y cuello para los estudiantes de primer año de la carrera de Estomatología de Pinar del Río. Material y método: se realizó un estudio cualitativo. Para obtener los resultados se utilizó el método materialista dialéctico. Para la dialéctica del desarrollo del proceso estudiado se utilizaron los métodos teóricos, empíricos, el estudio profundo del tema, tipo de plataforma a utilizar y criterios de los especialistas. Para su procesamiento se utilizaron técnicas estadísticas descriptivas e inferenciales no paramétricas. Resultados: debido a la necesidad de fortalecer en los estudiantes las habilidades en la utilización de las tecnologías de la informática y las comunicaciones, se elaboró el software de la anatomía del sistema osteomioarticular de cabeza y cuello "Aprendiendo anatomía" mediante imágenes, videos y textos. Conclusiones: el software constituye un aporte al proceso enseñanza aprendizaje, el cual facilita el trabajo independiente y autopreparación mediante la interactividad con el contenido, retroalimentación y evaluación utilizando medios de enseñanza modernos, lo cual tributa al modo de actuación del futuro egresado.

  8. Historia deldel = History of Padel

    Directory of Open Access Journals (Sweden)

    Bernardino Javier Sánchez-Alcaraz Martínez

    2013-10-01

    Full Text Available El presente trabajo resume la historia del deporte deldel. Existen dos versiones sobre el origen deldel. La primera versión relaciona los antecedentes deldel con los de otros deportes de raqueta como el tenis o el bádminton, siendo su origen común el jeu de la paume francés. Posteriormente, surgen variantes en Estados Unidos como el Paddle Tennis y el Platform Tennis, siendo versiones reducidas del tenis, pero con elementos muy comunes al pádel actual. La segunda versión, aprobada por la Federación Internacional de Pádel, afirma que este deporte nació en México, en 1969, a través del empresario Enrique Corcuera.--------------------------------------------------------------------This research summarizes the history of paddle sport. There are two versions about the origin of paddle. The first version relates the history of paddle with other racket sports like tennis or badminton, and its common origin of the Jeu de Paume French. Later, in in the United States, appear two sports called Paddle Tennis and Platform Tennis, which are reduced versions of tennis sport, but these have lot of common characteristics with paddle. The second version, approved by the International Padel Federation, said the sport was born in Mexico in 1969, through the businessman Enrique Corcuera.

  9. Determinantes del ingreso y del gasto corriente de los hogares

    Directory of Open Access Journals (Sweden)

    Muñoz C., Manuel

    2004-06-01

    Full Text Available Este ensayo de investigación empírica analiza los determinantes del ingreso y del gasto en los hogares colombianos. Utilizando un modelo del ciclo de vida con datos de la encuesta de hogares de 1994 y 1995, muestra que el comportamiento del ingreso está afectado principalmente por las características demográficas del hogar y los rasgos socio ocupacionales de sus miembros. El comportamiento del gasto está determinado ante todo por el ingreso y, en menor medida, por las características sociales del hogar y el gasto de otros hogares con características similares. También examina la influencia de la incertidumbre acerca de los ingresos en el gasto de los hogares para comprobar si estos actúan con motivos de precaución.

  10. Sleep enhances false memories depending on general memory performance.

    Science.gov (United States)

    Diekelmann, Susanne; Born, Jan; Wagner, Ullrich

    2010-04-02

    Memory is subject to dynamic changes, sometimes giving rise to the formation of false memories due to biased processes of consolidation or retrieval. Sleep is known to benefit memory consolidation through an active reorganization of representations whereas acute sleep deprivation impairs retrieval functions. Here, we investigated whether sleep after learning and sleep deprivation at retrieval enhance the generation of false memories in a free recall test. According to the Deese, Roediger, McDermott (DRM) false memory paradigm, subjects learned lists of semantically associated words (e.g., "night", "dark", "coal", etc.), lacking the strongest common associate or theme word (here: "black"). Free recall was tested after 9h following a night of sleep, a night of wakefulness (sleep deprivation) or daytime wakefulness. Compared with memory performance after a retention period of daytime wakefulness, both post-learning nocturnal sleep as well as acute sleep deprivation at retrieval significantly enhanced false recall of theme words. However, these effects were only observed in subjects with low general memory performance. These data point to two different ways in which sleep affects false memory generation through semantic generalization: one acts during consolidation on the memory trace per se, presumably by active reorganization of the trace in the post-learning sleep period. The other is related to the recovery function of sleep and affects cognitive control processes of retrieval. Both effects are unmasked when the material is relatively weakly encoded. Crown Copyright 2009. Published by Elsevier B.V. All rights reserved.

  11. Estudio del CH interestelar

    Science.gov (United States)

    Olano, C.; Lemarchand, G.; Sanz, A. J.; Bava, J. A.

    El objetivo principal de este proyecto consiste en el estudio de la distribución y abundancia del CH en nubes interestelares a través de la observación de las líneas hiperfinas del CH en 3,3 GHz. El CH es una molécula de amplia distribución en el espacio interestelar y una de las pocas especies que han sido observadas tanto con técnicas de radio como ópticas. Desde el punto de vista tecnológico se ha desarrollado un cabezal de receptor que permitirá la realización de observaciones polarimétricas en la frecuencia de 3,3 GHz, con una temperatura del sistema de 60 K y un ancho de banda de 140 MHz, y que será instalado en el foco primario de la antena parabólica del IAR. El cabezal del receptor es capaz de detectar señales polarizadas, separando las componentes de polarización circular derecha e izquierda. Para tal fin el cabezal consta de dos ramas receptoras que amplificarán la señal y la trasladarán a una frecuencia más baja (frecuencia intermedia), permitiendo de esa forma un mejor transporte de la señal a la sala de control para su posterior procesamiento. El receptor además de tener características polarimétricas, podrá ser usado en el continuo y en la línea, utilizando las ventajas observacionales y de procesamiento de señal que actualmente posee el IAR.

  12. La conservación de los fondos del Archivo del Tribunal Militar Territorial Segundo

    Directory of Open Access Journals (Sweden)

    Joaquín Gil Honduvilla

    2009-12-01

    Full Text Available El presente trabajo describe el proceso por el que los fondos del archivo del Tribunal Militar Territorial Segundo fueron objeto de un convenio colaboración entre el Ministerio de Defensa, la Consejería de la Presidencia de la Junta de Andalucía y la Fundación Centro de Estudios Andaluces para su informatización y conservación. Se muestra la importancia del archivo, así como su organización y la legislación por la que se rige. El interés de la administración autonómica por colaborar en la ordenación de esta documentación no puede disociarse tampoco del proceso de recuperación de memoria histórica que existe actualmente en nuestra sociedad._____________________ABSTRACT:This work describes the process which led to the fact that the funds of the archive of the Tribunal Militar Territorial Segundo (The Second Territorial Military Tribunal became the object of a collaboration agreement between the Ministry of Defence, the Consejería de la Presidencia (Regional Ministry of Presidency of Junta de Andalucía and the Fundación Centro de Estudios Andaluces (Centre of Andalusian Studies Foundation concerning its computerisation and maintenance. The paper shows the importance of the archive, as well as its organisation and the laws it is subject to. The interest of the autonomous public administration in collaborating in the organisation of that documentation cannot be separated from the process of recuperation of the historical memory which is present in our society today.  

  13. La pluridimensionalidad del rol del docente hospitalario

    Directory of Open Access Journals (Sweden)

    Marian Serradas Fonseca

    2015-07-01

    Full Text Available Este trabajo es el fruto de la observación y la investigación en la trayectoria personal y profesional de la autora dedicada a la educación de niños y niñas en situación de enfermedad u hospitalización. El objetivo de este ensayo es intentar definir de manera específica, el papel, tareas y competencias que el profesional del ámbito educativo tiene en la atención educativa hospitalaria; haciendo especial énfasis en la importancia de la formación de este profesional abogándose por una preparación que permita brindar una atención educativa de calidad a los niños y niñas en situación de enfermedad u hospitalizados.

  14. Towards Terabit Memories

    Science.gov (United States)

    Hoefflinger, Bernd

    Memories have been the major yardstick for the continuing validity of Moore's law. In single-transistor-per-Bit dynamic random-access memories (DRAM), the number of bits per chip pretty much gives us the number of transistors. For decades, DRAM's have offered the largest storage capacity per chip. However, DRAM does not scale any longer, both in density and voltage, severely limiting its power efficiency to 10 fJ/b. A differential DRAM would gain four-times in density and eight-times in energy. Static CMOS RAM (SRAM) with its six transistors/cell is gaining in reputation because it scales well in cell size and operating voltage so that its fundamental advantage of speed, non-destructive read-out and low-power standby could lead to just 2.5 electrons/bit in standby and to a dynamic power efficiency of 2aJ/b. With a projected 2020 density of 16 Gb/cm², the SRAM would be as dense as normal DRAM and vastly better in power efficiency, which would mean a major change in the architecture and market scenario for DRAM versus SRAM. Non-volatile Flash memory have seen two quantum jumps in density well beyond the roadmap: Multi-Bit storage per transistor and high-density TSV (through-silicon via) technology. The number of electrons required per Bit on the storage gate has been reduced since their first realization in 1996 by more than an order of magnitude to 400 electrons/Bit in 2010 for a complexity of 32Gbit per chip at the 32 nm node. Chip stacking of eight chips with TSV has produced a 32GByte solid-state drive (SSD). A stack of 32 chips with 2 b/cell at the 16 nm node will reach a density of 2.5 Terabit/cm². Non-volatile memory with a density of 10 × 10 nm²/Bit is the target for widespread development. Phase-change memory (PCM) and resistive memory (RRAM) lead in cell density, and they will reach 20 Gb/cm² in 2D and higher with 3D chip stacking. This is still almost an order-of-magnitude less than Flash. However, their read-out speed is ~10-times faster, with as yet

  15. The Agency of Memory Objects

    DEFF Research Database (Denmark)

    Wiegand, Frauke Katharina

    2016-01-01

    and international tourists’ photographs and notes, especially their visual encounters with the exhibition, are understood as participatory interactions in the course of memory work. The article’s aim is twofold: introducing an ANT-inspired methodology to the field of memory studies, and mapping a Sowetan memory......This article analyses the multifarious acts of cultural memory taking place in the small, almost hidden, exhibition space of the famous Regina Mundi Church in Soweto, South Africa, home to the photographic exhibition “The Story of Soweto.” Next to the photographs (1950-2010) by well-known apartheid...... of action, examining the idea that objects, such as images, that leave a trace can act as mediators of memory. Starting from visitors’ appropriations of the exhibition space, the essay sheds light on the different life cycles of memory objects, in particular images, and their diverse mediations. Domestic...

  16. Fault Tolerant External Memory Algorithms

    DEFF Research Database (Denmark)

    Jørgensen, Allan Grønlund; Brodal, Gerth Stølting; Mølhave, Thomas

    2009-01-01

    Algorithms dealing with massive data sets are usually designed for I/O-efficiency, often captured by the I/O model by Aggarwal and Vitter. Another aspect of dealing with massive data is how to deal with memory faults, e.g. captured by the adversary based faulty memory RAM by Finocchi and Italiano....... However, current fault tolerant algorithms do not scale beyond the internal memory. In this paper we investigate for the first time the connection between I/O-efficiency in the I/O model and fault tolerance in the faulty memory RAM, and we assume that both memory and disk are unreliable. We show a lower...... bound on the number of I/Os required for any deterministic dictionary that is resilient to memory faults. We design a static and a dynamic deterministic dictionary with optimal query performance as well as an optimal sorting algorithm and an optimal priority queue. Finally, we consider scenarios where...

  17. Is memory for music special?

    Science.gov (United States)

    Schulkind, Matthew D

    2009-07-01

    Although psychologists since Hermann Ebbinghaus have studied memory, research in this area has focused on visual and verbal stimuli with little attention paid to music. This bias is surprising because of the ubiquity of music in human cultures across history as well as current cultural beliefs that memory for music is "special." This paper examines the question of whether memory for music is special by addressing two related questions: First, do cultural beliefs about the mnemonic power of music stand up to empirical test? Second, can theories designed to explain memory for non-musical stimuli be applied to musical stimuli? A review of the literature suggests that music is special in some circumstances but not others and that some theories designed to explain cognitive processing of linguistic stimuli apply reasonably well to musical stimuli. Thus, although the question of whether memory for music is special remains open, the unique structure of musical stimuli strongly suggests that memory for music is indeed special.

  18. The Source for Learning & Memory Strategies.

    Science.gov (United States)

    Richards, Regina G.

    This book is a comprehensive guide to learning and memory strategies for all students and especially those with learning problems. Chapter 1, on memory and the brain, explains brain cells, the cortex, function of the cerebral lobes, and other brain structures. Chapter 2 examines the memory process and discusses sensory memory, short-term memory,…

  19. Performing Memory in Art and Popular Culture

    NARCIS (Netherlands)

    Plate, L.; Smelik, A.M.

    2013-01-01

    This volume pursues a new line of research in cultural memory studies by understanding memory as a performative act in art and popular culture. The authors take their cue from the observation that art and popular culture enact memory and generate processes of memory. They do memory, and in this

  20. Working memory and simultaneous interpreting

    OpenAIRE

    Timarova, Sarka

    2009-01-01

    Working memory is a cognitive construct underlying a number of abilities, and it has been hypothesised for many years that it is crucial for interpreting. A number of studies have been conducted with the aim to support this hypothesis, but research has not yielded convincing results. Most researchers focused on studying working memory differences between interpreters and non-interpreters with the rationale that differences in working memory between the two groups would provide evidence of wor...

  1. Obesity and episodic memory function.

    Science.gov (United States)

    Loprinzi, Paul D; Frith, Emily

    2018-04-17

    Obesity-related lifestyle factors, such as physical activity behavior and dietary intake, have been shown to be associated with episodic memory function. From animal work, there is considerable biological plausibility linking obesity with worse memory function. There are no published systematic reviews evaluating the effects of obesity on episodic memory function among humans, and examining whether physical activity and diet influences this obesity-memory link. Thus, the purpose of this systematic review was to evaluate the totality of research examining whether obesity is associated with episodic memory function, and whether physical activity and dietary behavior confounds this relationship. A review approach was employed, using PubMed, PsychInfo, and Sports Discus databases. Fourteen studies met our criteria. Among these 14 reviewed studies, eight were cross-sectional, four were prospective, and two employed a randomized controlled experimental design. Twelve of the 14 studies did not take into consideration dietary behavior in their analysis, and similarly, nine of the 14 studies did not take into consideration participant physical activity behavior. Among the 14 studies, ten found an inverse association of weight status on memory function, but for one of these studies, this association was attenuated after controlling for physical activity. Among the 14 evaluated studies, four did not find a direct effect of weight status on memory. Among the four null studies, one, however, found an indirect effect of BMI on episodic memory and another found a moderation effect of BMI and age on memory function. It appears that obesity may be associated with worse memory function, with the underlying mechanisms discussed herein. At this point, it is uncertain whether adiposity, itself, is influencing memory changes, or rather, whether adiposity-related lifestyle behaviors (e.g., physical inactivity and diet) are driving the obesity-memory relationship.

  2. Memory transition between communicating agents

    Directory of Open Access Journals (Sweden)

    Elena FELL

    2012-01-01

    Full Text Available What happens to a memory when it has been externalised and embodied but has not reached its addressee yet? A letter that has been written but has not been read, a monument before it is unveiled or a Neolithic tool buried in the ground – all these objects harbour human memories engrained in their physicality; messages intended for those who will read the letter, admire the monument and hold the tool. According to Ilyenkov’s theory of objective idealism, the conscious and wilful input encoded in all manmade objects as the ‘ideal’ has an objective existence, independent from the author, but this existence lasts only while memories are shared between communicating parties. If all human minds were absent from the world for a period of time, the ‘ideal’, or memories, would cease to exist. They would spring back to existence, however, once humans re-entered the world. Ilyenkov’s analysis of memories existing outside an individual human consciousness is informative and thorough but, following his line of thought, we would have to accept an ontological gap in the process of memory acquisition, storage and transmission. If there is a period, following memory acquisition and preceding its transmission, when memories plainly do not exist, then each time a new reader, spectator or user perceives them, he or she must create the author’s memories ex nihilo. Bergson’s theory of duration and intuition can help us to resolve this paradox.This paper will explore the ontological characteristics of memory passage in communication taken at different stages of the process. There will be an indication of how the findings of this investigation could be applicable to concrete cases of memory transmission. In particular, this concerns intergenerational communication, technological memory, the use of digital devices and the Internet.

  3. Mental images in episodic memory

    OpenAIRE

    Han, KyungHun

    2009-01-01

    Episodic memory, i.e. memorization of information within a spatiotemporal environment, is affected by Alzheimer's disease (AD) but its loss may also occur in the normal aging process. The purpose of this study is to analyze and evaluate episodic memory in patients with AD by examining their cognitive skills in episodic memory through the introspection technique. A new method was used, wherein we assessed mental images of the subject's own past recalled in the mind like projected pictures and ...

  4. Long memory and changing persistence

    DEFF Research Database (Denmark)

    Kruse, Robinson; Sibbertsen, Philipp

    We study the empirical behaviour of semi-parametric log-periodogram estimation for long memory models when the true process exhibits a change in persistence. Simulation results confirm theoretical arguments which suggest that evidence for long memory is likely to be found. A recently proposed test...... by Sibbertsen and Kruse (2009) is shown to exhibit noticeable power to discriminate between long memory and a structural change in autoregressive parameters....

  5. Olfactory memory traces in Drosophila

    OpenAIRE

    Berry, Jacob; Krause, William C.; Davis, Ronald L.

    2008-01-01

    In Drosophila the fruit fly, coincident exposure to an odor and an aversive electric shock can produce robust behavioral memory. This behavioral memory is thought to be regulated by cellular memory traces within the central nervous system of the fly. These molecular, physiological or structural changes in neurons, induced by pairing odor and shock, regulate behavior by altering the neurons’ response to the learned environment. Recently, novel in vivo functional imaging techniques have allowed...

  6. Incidence of chemotherapy-induced amenorrhea in premenopausal women treated with adjuvant FOLFOX for colorectal cancer.

    Science.gov (United States)

    Cercek, Andrea; Siegel, Cara L; Capanu, Marinela; Reidy-Lagunes, Diane; Saltz, Leonard B

    2013-09-01

    Studies indicate that the incidence of young women diagnosed with colorectal cancer is rising, thus there is an increasing number of female colorectal cancer survivors of premenopausal and child-bearing age. Adjuvant FOLFOX (5-fluorouracil, leucovorin, and oxaliplatin) chemotherapy is the most widely used standard treatment for stage III and high-risk stage II colon cancer. We evaluated the incidence of FOLFOX-induced amenorrhea in women age 50 and younger treated with adjuvant therapy for colorectal cancer. A search of pharmacy records identified 119 women age 50 or younger who received adjuvant FOLFOX chemotherapy at Memorial Sloan-Kettering for stage II or III colorectal cancer from January 2002 and January 2011. Eligible patients were mailed an anonymous questionnaire. The returned surveys were reviewed and the results tallied. Seventy-three patients returned the questionnaire. Twenty-four patients were excluded from analysis: 19 were treated with pelvic radiotherapy, 2 patients had undergone bilateral oophorectomy, 2 had a hysterectomy, and 1 stopped menstruating before diagnosis. Forty-nine patient responses were analyzed. In total, 41% (n = 20) experienced amenorrhea during chemotherapy. Sixteen percent had persistent amenorrhea 1 year after completion of chemotherapy. The incidence of amenorrhea during chemotherapy trended higher in patients aged older than 40 compared with patients aged 40 and younger (59% vs. 31% [P = .075]). There was no statistically significant difference in persistent amenorrhea between the 2 age groups (24% vs. 13%; P = .42). In this retrospective series, there appears to be a trend toward FOLFOX induced amenorrhea during chemotherapy increasing with age. Twenty-four percent of women older than the age of 40 were found to have persistent amenorrhea after FOLFOX therapy. Because of the small sample size, the study is underpowered to detect a statistically significant difference between older and younger patients. Prospective studies

  7. Safety and treatment outcomes of first-line pazopanib in renal cell carcinoma: A prospective observational study in a single Malaysia tertiary hospital

    Directory of Open Access Journals (Sweden)

    Azmi Nor Mohd Farez Ahmat

    2017-12-01

    Full Text Available Introduction: Pazopanib is the standard of care for metastatic renal cell carcinoma (mRCC. Previous studies on this indication were limited to patients who were selected on the basis of a fairly preserved performance status and normal organ function. Thus, the clinical trial population may not be representative of all patients seen in real-world practice. Based on these considerations, this prospective single-centre observational study was designed to evaluate the treatment outcomes and safety profile of pazopanib in Malaysian population. Patients and methods: Patients prescribed with pazopanib between June 2015 and June 2017 were recruited and followed up for 2-years or till death whichever comes first. Progression-free survival (PFS and overall survival (OS were evaluated. Multivariate and survival analysis were performed. Results: Twenty-seven patients were treated with pazopanib where 89% had clear cell histology.  Sixteen patients (59% were intermediate risk and 41% were poor risk based on Memorial Sloan Kettering Cancer Center (MSKCC criteria. All patients experienced at least one adverse event. The most common were cutaneous toxicity (92% followed by proteinuria, hypertension, diarrhoea and mucositis. Treatment interruption was needed in 15 patients. The median PFS and OS were 9.57 months and 15.5 months, respectively. In multivariate analysis, MSKCC risk score demonstrates strong predictive treatment outcome. The median PFS was 14.5 months in intermediate risk and 3.96 months in poor risk (OR: 0.2, p<0.001. However, the median OS is still immature to be reported since 63% of intermediate risk group is still alive at 2-years follow-up. Conclusion: In mRCC patients, treatment with pazopanib was effective in patients with intermediate risk group. In terms of safety, patient tolerated pazopanib quite well with mostly experienced grade 1 to 2 adverse events.

  8. Outcomes and Prognostic Variables in Adenoid Cystic Carcinoma of the Head and Neck: A Recent Experience

    International Nuclear Information System (INIS)

    Gomez, Daniel R.; Hoppe, Bradford S.; Wolden, Suzanne L.; Zhung, Joanne E.; Patel, Snehal G.; Kraus, Dennis H.; Shah, Jatin P.; Ghossein, Ronald A.; Lee, Nancy Y.

    2008-01-01

    Purpose: To analyze the recent experience of patients with adenoid cystic carcinoma treated with radiation therapy at Memorial Sloan-Kettering Cancer Center. Methods and Materials: From 1990 to 2004, a total of 59 patients with a diagnosis of primary adenoid cystic carcinoma of the head and neck received radiation therapy at our institution. The subsite distribution was oral cavity, 28% (n = 17); paranasal sinuses, 22% (n = 13); parotid, 14% (n = 8); submandibular, 14% (n = 8); oropharynx, 10% (n = 6); sublingual, 3% (n = 2); nasopharynx, 3% (n = 2); and other, 5% (n = 3). T Stage distribution was T1, 34% (n = 20); T2, 19% (n = 11); T3, 14% (n = 8); and T4, 34% (n = 20). Twenty-nine percent of patients (n = 17) were treated with intensity-modulated radiation therapy; 25% (n =15), with three-dimensional conformal therapy, and the remainder, with conventional techniques. Ninety percent (n = 53) of patients received treatment including the base of skull. Results: Median follow-up for surviving patients was 5.9 years. Five-year and 10-year rates of local control and distant metastases-free survival were 91%/81% and 81%/49%, respectively. Five-year and 10-year rates of disease-free and overall survival were 76%/40% and 87%/65%, respectively. On univariate analysis, stage T4 (p = 0.004) and gross/clinical nerve involvement (p = 0.002) were associated with decreased progression free survival, whereas stage T4 and lymph node involvement were associated with decreased overall survival (p = 0.046 and p < 0.001, respectively). Conclusions: Radiation therapy in combination with surgery produces excellent rates of local control, although distant metastases account for a high proportion of failures. Routine treatment to the base of skull reduces the significance of histologic perineural invasion, but major nerve involvement remains an adverse prognostic factor

  9. Local Control With 21-Gy Radiation Therapy for High-Risk Neuroblastoma

    International Nuclear Information System (INIS)

    Casey, Dana L.; Kushner, Brian H.; Cheung, Nai-Kong V.; Modak, Shakeel; LaQuaglia, Michael P.; Wolden, Suzanne L.

    2016-01-01

    Purpose: To evaluate local control after 21-Gy radiation therapy (RT) to the primary site in patients with high-risk neuroblastoma. Methods and Materials: After receiving dose-intensive chemotherapy and gross total resection (GTR), 246 patients (aged 1.2-17.9 years, median 4.0 years) with high-risk neuroblastoma underwent RT to the primary site at Memorial Sloan Kettering from 2000 to 2014. Radiation therapy consisted of 21 Gy in twice-daily fractions of 1.5 Gy each. Local failure (LF) was correlated with biologic prognostic factors and clinical findings at the time of diagnosis and start of RT. Results: Median follow-up of surviving patients was 6.4 years. Cumulative incidence of LF was 7.1% at 2 years after RT and 9.8% at 5 years after RT. The isolated LF rate was 3.0%. Eighty-six percent of all local failures were within the RT field. Local control was worse in patients who required more than 1 surgical resection to achieve GTR (22.4% vs 8.3%, P=.01). There was also a trend toward inferior local control with MYCN-amplified tumors or serum lactate dehydrogenase ≥1500 U/L (P=.09 and P=.06, respectively). Conclusion: After intensive chemotherapy and maximal surgical debulking, hyperfractionated RT with 21 Gy in high-risk neuroblastoma results in excellent local control. Given the young patient age, concern for late effects, and local control >90%, dose reduction may be appropriate for patients without MYCN amplification who achieve GTR.

  10. Intensity-modulated radiotherapy -the State of the Art

    International Nuclear Information System (INIS)

    Ling, C.

    2002-01-01

    Full text: In the last two decades of the last century, the development of three-dimensional conformal radiotherapy (3D-CRT) has substantially reduces the volume of critical organs irradiated to high doses, and has permitted the increase of tumor dose without concomitant increase in normal tissue complication. At Memorial Sloan Kettering Cancer Center, a clinical trial in cancer of the prostate has accrued >1600 patient and the prescription dose has been escalated to 81 Gy with 3D-CRT, and to 86.4 Gy using intensity modulated radiotherapy (IMRT), with promising results. 3D-CRT and IMRT involves the delineation of target and non-target structures from patient-specific 3D image data-sets (primarily CT, sometimes supplemented with MRI, PET etc.), the calculation and display of 3D dose distributions, the analysis and evaluation of structure-specific dose-volume data (DVH-dose volume histogram), radiation delivery with computer-controlled multileaf collimators (MLC), and treatment verification with electronic portal images. However, the dose distribution conformality achieved with 3D-CRT can be further improved by the use of computer-optimized IMRT. In addition, the treatment design phase of 3D-CRT involves several iterative steps and can be time-consuming, particularly when the anatomical geometry is complex. Thus, IMRT is an incremental advance from 3D-CRT with two key enhancements: 1) computerized iterative treatment plan optimization, and 2) the use of intensity-modulated radiation beams. To deliver the IM beams, one efficacious approach is to use MLC in the dynamic mode, using the so-called sliding-window technique, i.e. the leaves of the MLC are in motion while the radiation is being delivered. Since 1995, we have treated over 1500 patients with IMRT. This discussion shall describe the physical aspects of IMRT, emphasizing those features and benefits unique to this approach. Pertinent clinical results will also be briefly presented

  11. Clinical Application of Picodroplet Digital PCR Technology for Rapid Detection of EGFR T790M in Next-Generation Sequencing Libraries and DNA from Limited Tumor Samples.

    Science.gov (United States)

    Borsu, Laetitia; Intrieri, Julie; Thampi, Linta; Yu, Helena; Riely, Gregory; Nafa, Khedoudja; Chandramohan, Raghu; Ladanyi, Marc; Arcila, Maria E

    2016-11-01

    Although next-generation sequencing (NGS) is a robust technology for comprehensive assessment of EGFR-mutant lung adenocarcinomas with acquired resistance to tyrosine kinase inhibitors, it may not provide sufficiently rapid and sensitive detection of the EGFR T790M mutation, the most clinically relevant resistance biomarker. Here, we describe a digital PCR (dPCR) assay for rapid T790M detection on aliquots of NGS libraries prepared for comprehensive profiling, fully maximizing broad genomic analysis on limited samples. Tumor DNAs from patients with EGFR-mutant lung adenocarcinomas and acquired resistance to epidermal growth factor receptor inhibitors were prepared for Memorial Sloan-Kettering-Integrated Mutation Profiling of Actionable Cancer Targets sequencing, a hybrid capture-based assay interrogating 410 cancer-related genes. Precapture library aliquots were used for rapid EGFR T790M testing by dPCR, and results were compared with NGS and locked nucleic acid-PCR Sanger sequencing (reference high sensitivity method). Seventy resistance samples showed 99% concordance with the reference high sensitivity method in accuracy studies. Input as low as 2.5 ng provided a sensitivity of 1% and improved further with increasing DNA input. dPCR on libraries required less DNA and showed better performance than direct genomic DNA. dPCR on NGS libraries is a robust and rapid approach to EGFR T790M testing, allowing most economical utilization of limited material for comprehensive assessment. The same assay can also be performed directly on any limited DNA source and cell-free DNA. Copyright © 2016 American Society for Investigative Pathology and the Association for Molecular Pathology. Published by Elsevier Inc. All rights reserved.

  12. Randomized Controlled Trial of Family Therapy in Advanced Cancer Continued Into Bereavement.

    Science.gov (United States)

    Kissane, David W; Zaider, Talia I; Li, Yuelin; Hichenberg, Shira; Schuler, Tammy; Lederberg, Marguerite; Lavelle, Lisa; Loeb, Rebecca; Del Gaudio, Francesca

    2016-06-01

    Systematic family-centered cancer care is needed. We conducted a randomized controlled trial of family therapy, delivered to families identified by screening to be at risk from dysfunctional relationships when one of their relatives has advanced cancer. Eligible patients with advanced cancer and their family members screened above the cut-off on the Family Relationships Index. After screening 1,488 patients or relatives at Memorial Sloan Kettering Cancer Center or three related community hospice programs, 620 patients (42%) were recruited, which represented 170 families. Families were stratified by three levels of family dysfunction (low communicating, low involvement, and high conflict) and randomly assigned to one of three arms: standard care or 6 or 10 sessions of a manualized family intervention. Primary outcomes were the Complicated Grief Inventory-Abbreviated (CGI) and Beck Depression Inventory-II (BDI-II). Generalized estimating equations allowed for clustered data in an intention-to-treat analysis. On the CGI, a significant treatment effect (Wald χ(2) = 6.88; df = 2; P = .032) and treatment by family-type interaction was found (Wald χ(2) = 20.64; df = 4; P families. Low-communicating families improved by 6 months of bereavement. In the standard care arm, 15.5% of the bereaved developed a prolonged grief disorder at 13 months of bereavement compared with 3.3% of those who received 10 sessions of intervention (Wald χ(2) = 8.31; df = 2; P =.048). No significant treatment effects were found on the BDI-II. Family-focused therapy delivered to high-risk families during palliative care and continued into bereavement reduced the severity of complicated grief and the development of prolonged grief disorder. © 2016 by American Society of Clinical Oncology.

  13. Marijuana use and increased risk of squamous cell carcinoma of the head and neck.

    Science.gov (United States)

    Zhang, Z F; Morgenstern, H; Spitz, M R; Tashkin, D P; Yu, G P; Marshall, J R; Hsu, T C; Schantz, S P

    1999-12-01

    Marijuana is the most commonly used illegal drug in the United States. In some subcultures, it is widely perceived to be harmless. Although the carcinogenic properties of marijuana smoke are similar to those of tobacco, no epidemiological studies of the relationship between marijuana use and head and neck cancer have been published. The relationship between marijuana use and head and neck cancer was investigated by a case-control study of 173 previously untreated cases with pathologically confirmed diagnoses of squamous cell carcinoma of the head and neck and 176 cancer-free controls at Memorial Sloan-Kettering Cancer Center between 1992 and 1994. Epidemiological data were collected by using a structured questionnaire, which included history of tobacco smoking, alcohol use, and marijuana use. The associations between marijuana use and head and neck cancer were analyzed by Mantel-Haenszel methods and logistic regression models. Controlling for age, sex, race, education, alcohol consumption, pack-years of cigarette smoking, and passive smoking, the risk of squamous cell carcinoma of the head and neck was increased with marijuana use [odds ratio (OR) comparing ever with never users, 2.6; 95% confidence interval (CI), 1.1-6.6]. Dose-response relationships were observed for frequency of marijuana use/day (P for trend marijuana use (P for trend marijuana use were observed with cigarette smoking, mutagen sensitivity, and to a lesser extent, alcohol use. Our results suggest that marijuana use may increase the risk of head and neck cancer with a strong dose-response pattern. Our analysis indicated that marijuana use may interact with mutagen sensitivity and other risk factors to increase the risk of head and neck cancer. The results need to be interpreted with some caution in drawing causal inferences because of certain methodological limitations, especially with regard to interactions.

  14. Expression and functional role of orphan receptor GPR158 in prostate cancer growth and progression.

    Directory of Open Access Journals (Sweden)

    Nitin Patel

    Full Text Available Prostate cancer (PCa is the second-leading cause of cancer-related mortality, after lung cancer, in men from developed countries. In its early stages, primary tumor growth is dependent on androgens, thus generally can be controlled by androgen deprivation therapy (ADT. Eventually however, the disease progresses to castration-resistant prostate cancer (CRPC, a lethal form in need of more effective treatments. G-protein coupled receptors (GPCRs comprise a large clan of cell surface proteins that have been implicated as therapeutic targets in PCa growth and progression. The findings reported here provide intriguing evidence of a role for the newly characterized glutamate family member GPR158 in PCa growth and progression. We found that GPR158 promotes PCa cell proliferation independent of androgen receptor (AR functionality and that this requires its localization in the nucleus of the cell. This suggests that GPR158 acts by mechanisms different from other GPCRs. GPR158 expression is stimulated by androgens and GPR158 stimulates AR expression, implying a potential to sensitize tumors to low androgen conditions during ADT via a positive feedback loop. Further, we found GPR158 expression correlates with a neuroendocrine (NE differentiation phenotype and promotes anchorage-independent colony formation implying a role for GPR158 in therapeutic progression and tumor formation. GPR158 expression was increased at the invading front of prostate tumors that formed in the genetically defined conditional Pten knockout mouse model, and co-localized with elevated AR expression in the cell nucleus. Kaplan-Meier analysis on a dataset from the Memorial Sloan Kettering cancer genome portal showed that increased GPR158 expression in tumors is associated with lower disease-free survival. Our findings strongly suggest that pharmaceuticals targeting GPR158 activities could represent a novel and innovative approach to the prevention and management of CRPC.

  15. Robert R. Shaw, MD: thoracic surgical hero, Afghanistan medical pioneer, champion for the patient, never a surgical society president.

    Science.gov (United States)

    Urschel, Harold C; Urschel, Betsey Bradley

    2012-06-01

    Dr Robert R. Shaw arrived in Dallas to practice Thoracic Surgery in 1937, as John Alexander's 7th Thoracic Surgical Resident from Michigan University Medical Center. Dr Shaw's modus operandi was, "You can accomplish almost anything, if you don't care who gets the credit." He was a remarkable individual who cared the most about the patient and very little about getting credit for himself. From 1937 to 1970, Dr Shaw established one of the largest lung cancer surgical centers in the world in Dallas, Texas. It was larger than M.D. Anderson and Memorial Sloan-Kettering Hospitals put together regarding the surgical treatment of lung cancer patients. To accomplish this, he had the help of Dr Donald L. Paulson, who trained at the Mayo Clinic and served as Chief of Thoracic Surgery at Brook Army Hospital during the Second World War. Following the War, because of his love for Texas, he ended up as a partner of Dr Shaw in Dallas. Together, they pursued the development of this very large surgical lung cancer center. Dr Shaw and his wife Ruth went to Afghanistan with Medico multiple times to teach men modern cardiac and thoracic surgery. They also served as consultants on Medico's Ship of Hope in Africa. Dr Shaw initiated multiple new operations including: 1) resection of Pancoast's cancer of the lung after preoperative irradiation; 2) upper lobe of the lung bronchoplasty, reattaching (and saving) the lower lobe to prevent the "disabling" pneumonectomy; and 3) resections of pulmonary mucoid impaction of the lung in asthmatics. Because of his humility and giving "the credit to others," Dr Shaw was never President of a major medical or surgical association. Copyright © 2012 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.

  16. WE-A-207-00: In Memoriam of Jacques Ovadia - Reinvigorating Scientific Excellence: Electron Beam Therapy - Past, Present and Future

    International Nuclear Information System (INIS)

    2015-01-01

    The Medical Physics community lost one of its early pioneers in radiation oncology physics, Jacques Ovadia, who passed away in April of 2014 at the age of 90. Jacques received his Ph.D. in Nuclear Physics from the University of Illinois at Urbana in 1951. Subsequently, under the guidance of John Laughlin, he was introduced to the field of Medical Physics. When John moved to Memorial Sloan Kettering, Jacques followed him. There he gained clinical experience and expertise in the then cutting-edge field of high energy electron beam therapy. In 1956, Jacques joined Dr. Erich Uhlmann at Michael Reese Hospital in Chicago where one of the country’s first high energy medical linear accelerators had just been installed. During his 35 year tenure, Dr. Ovadia built a strong Medical Physics department that merged in 1984 with that of the University of Chicago. Jacques pioneered the use of high energy electron beams to treat deep seated tumors, multiple-field chest wall irradiation with variable electron energies, and even anticipated the current interest in high energy electron beam grid-therapy. At an early stage, he introduced a simulator, computerized treatment planning and in-house developed record and verify software. He retired in 1990 as Professor emeritus in Radiation and Cellular Biology at the University of Chicago. Dr. Ovadia was an early and strong supporter of AAPM. He was present at the Chicago ROMPS meeting where the decision was made to form an independent professional society for medical physics. He served as AAPM president in 1976. Jacques Ovadia is survived by his wife of 58 years, Florence, their daughter Corinne Graefe and son Marc Ovadia, MD, as well as four grandchildren and one great-grandchild. Jacques’ dynamic and ever enthusiastic personality inspired all who collaborated with him. He will be greatly missed

  17. Review of Recent US Value Frameworks-A Health Economics Approach: An ISPOR Special Task Force Report [6].

    Science.gov (United States)

    Willke, Richard J; Neumann, Peter J; Garrison, Louis P; Ramsey, Scott D

    2018-02-01

    The sixth section of our Special Task Force (STF) report reviews and comments on recent US-oriented value assessment frameworks, specifically those published by the American College of Cardiology/American Heart Association, the Institute for Clinical and Economic Research, the American Society of Clinical Oncology, the National Comprehensive Cancer Network, and the Memorial Sloan Kettering Cancer Center. We review published commentaries that address the validity, reliability, and conceptual underpinnings of these frameworks. We find common themes of critique regarding the strengths and limitations across frameworks. Particular shortcomings of some frameworks pose greater threats to their face validity and utility compared with others. The most significant limitations include lack of clear perspective (e.g., patient vs. health plan) and poor transparency in accounting for costs and benefits. We then review how each framework adheres to core STF recommendations, with particular emphasis on whether the framework can be used to support coverage decisions by health insurers, and whether it adheres to core principles of cost-effectiveness analysis. The Institute for Clinical and Economic Research framework most closely adheres to core STF recommendations. Others have significant limitations that vary widely from framework to framework. We also review how the frameworks follow STF recommendations for addressing potentially relevant issues beyond cost-effectiveness analysis - for example, equity in resource allocation and patient heterogeneity. Finally, we review whether and how each framework uses value thresholds and addresses affordability concerns. We conclude with suggestions for further research, particularly in the areas of testing the measurement and use of novel elements of value and deliberative processes. Copyright © 2018 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.

  18. Predicting Outcome in Patients with Rhabdomyosarcoma: Role of [18F]Fluorodeoxyglucose Positron Emission Tomography

    International Nuclear Information System (INIS)

    Casey, Dana L.; Wexler, Leonard H.; Fox, Josef J.; Dharmarajan, Kavita V.; Schoder, Heiko; Price, Alison N.; Wolden, Suzanne L.

    2014-01-01

    Purpose: To evaluate whether [ 18 F]fluorodeoxyglucose positron emission tomography (FDG-PET) response of the primary tumor after induction chemotherapy predicts outcomes in rhabdomyosarcoma (RMS). Methods and Materials: After excluding those with initial tumor resection, 107 patients who underwent FDG-PET after induction chemotherapy at Memorial Sloan Kettering Cancer Center from 2002 to 2013 were reviewed. Local control (LC), progression-free survival (PFS), and overall survival (OS) were calculated according to FDG-PET response and maximum standardized uptake value (SUV) at baseline (PET1/SUV1), after induction chemotherapy (PET2/SUV2), and after local therapy (PET3/SUV3). Receiver operator characteristic curves were used to determine the optimal cutoff for dichotomization of SUV1 and SUV2 values. Results: The SUV1 (<9.5 vs ≥9.5) was predictive of PFS (P=.02) and OS (P=.02), but not LC. After 12 weeks (median) of induction chemotherapy, 45 patients had negative PET2 scans and 62 had positive scans: 3-year PFS was 72% versus 44%, respectively (P=.01). The SUV2 (<1.5 vs ≥1.5) was similarly predictive of PFS (P=.005) and was associated with LC (P=.02) and OS (P=.03). A positive PET3 scan was predictive of worse PFS (P=.0009), LC (P=.05), and OS (P=.03). Conclusions: [ 18 F]fluorodeoxyglucose positron emission tomography is an early indicator of outcomes in patients with RMS. Future prospective trials may incorporate FDG-PET response data for risk-adapted therapy and early assessment of new treatment regimens

  19. The role of parotid gland irradiation in the development of severe hyposalivation (xerostomia) after intensity-modulated radiation therapy for head and neck cancer: Temporal patterns, risk factors, and testing the QUANTEC guidelines.

    Science.gov (United States)

    Owosho, Adepitan A; Thor, Maria; Oh, Jung Hun; Riaz, Nadeem; Tsai, C Jillian; Rosenberg, Haley; Varthis, Spyridon; Yom, Sae Hee K; Huryn, Joseph M; Lee, Nancy Y; Deasy, Joseph O; Estilo, Cherry L

    2017-04-01

    The aims of this study were to investigate temporal patterns and potential risk factors for severe hyposalivation (xerostomia) after intensity-modulated radiotherapy (IMRT) for head and neck cancer (HNC), and to test the two QUANTEC (Quantitative Analysis of Normal Tissue Effects in the Clinic) guidelines. Sixty-three patients treated at the Memorial Sloan Kettering Cancer Center between 2006 and 2015, who had a minimum of three stimulated whole mouth saliva flow measurements (WMSFM) at a median follow-up time of 11 (range: 3-24) months were included. Xerostomia was defined as WMSFM ≤25% compared to relative pre-radiotherapy. Patients were stratified into three follow-up groups: 1: xerostomia was 27%, 14% and 17% at follow-up time points 1, 2 and 3, respectively. At xerostomia (Dmean contra : 25 Gy vs. 15 Gy; Dmean ipsi : 44 Gy vs. 25 Gy). Patients with xerostomia had higher pre-RT WMSFM (3.5 g vs. 2.4 g), and had been treated more frequently with additional chemotherapy (93% vs. 63%; all 4 variables: p xerostomia was higher compared to patients without (26 Gy vs. 20 Gy). The RR as specified by the one- and two-gland QUANTEC guideline was 2.3 and 1.4 for patients with Xerostomia following IMRT peaks within six months post-radiotherapy and fades with time. Limiting the mean dose to both parotid glands (ipsilateral xerostomia. Both QUANTEC guidelines are effective in preventing xerostomia. Copyright © 2017 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

  20. A conversation with Susan Band Horwitz.

    Science.gov (United States)

    Horwitz, Susan Band; Goldman, I David

    2015-01-01

    Susan Band Horwitz is a Distinguished Professor and holds the Falkenstein Chair in Cancer Research at Albert Einstein College of Medicine in New York. She is co-chair of the Department of Molecular Pharmacology and associate director for therapeutics at the Albert Einstein Cancer Center. After graduating from Bryn Mawr College, Dr. Horwitz received her PhD in biochemistry from Brandeis University. She has had a continuing interest in natural products as a source of new drugs for the treatment of cancer. Her most seminal research contribution has been in the development of Taxol(®). Dr. Horwitz and her colleagues made the discovery that Taxol had a unique mechanism of action and suggested that it was a prototype for a new class of antitumor drugs. Although Taxol was an antimitotic agent blocking cells in the metaphase stage of the cell cycle, Dr. Horwitz recognized that Taxol was blocking mitosis in a way different from that of other known agents. Her group demonstrated that the binding site for Taxol was on the β-tubulin subunit. The interaction of Taxol with the β-tubulin subunit resulted in stabilized microtubules, essentially paralyzing the cytoskeleton, thereby preventing cell division. Dr. Horwitz served as president (2002-2003) of the American Association for Cancer Research (AACR). She is a member of the National Academy of Sciences, the Institute of Medicine, the American Academy of Arts and Sciences, and the American Philosophical Society. She has received numerous honors and awards, including the C. Chester Stock Award from Memorial Sloan Kettering Cancer Center, the Warren Alpert Foundation Prize from Harvard Medical School, the Bristol-Myers Squibb Award for Distinguished Achievement in Cancer Research, the American Cancer Society's Medal of Honor, and the AACR Award for Lifetime Achievement in Cancer Research. The following interview was conducted on January 23, 2014.