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Sample records for deinstitutionalisation stage important

  1. The long term importance of English primary care groups for integration in primary health care and deinstitutionalisation of hospital care

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    Nick Goodwin

    2001-03-01

    Full Text Available Purpose: This article reviews the impact of successive experiments in the development of primary care organisations in England and assesses the long-term importance of English primary care groups for the integration of health and community and health and social care and the deinstitutionalisation of hospital care. Theory: Governments in a number of Western countries are attempting to improve the efficiency, appropriateness and equity of their health systems. One of the main ways of doing this is to devolve provision and commissioning responsibility from national and regional organisations to more local agencies based in primary care. Such primary care organisations are allocated budgets that span both primary and secondary (hospital services and also, potentially, social care. Method: This article is based on a systematic review of the literature forthcoming from the UK Government's Department of Health-funded evaluations of successive primary care organisational developments. These include total purchasing pilots, GP commissioning group pilots, personal medical services pilots and primary care groups and trusts. Results: Primary care organisations in England have proved to be a catalyst in facilitating the development of integrated care working between primary and community health services. Conversely, primary care organisations have proved less effective in promoting integration between health and social care agencies where most progress has been made at the strategic commissioning level. The development of primary care trusts in England is heralding an end to traditional community hospitals. Conclusions: The development of primary care groups in England are but an intermediate step of a policy progression towards future primary care-based organisations that will functionally integrate primary and community health services with local authority services under a single management umbrella.

  2. Deinstitutionalisation from the perspective of sensemaking: An empirical investigation of the Electricity of Vietnam Corporation

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    Tham, H. A.

    This thesis is a study of deinstitutionalisation seeking to understand the evolvement of deinstitutionalisation process via the lens of sensemaking. It does so by conducting an in-depth qualitative, case study-based empirical study of the processual nature of deinstitutionalisation and the significance of organisational sensemaking during the deinstitutionalisation process. An interdisciplinary approach is adopted drawing insights from various literatures including institutional theory, sensemaking and social psychology. The need for greater understanding of the deinstitutionalisation phenomenon, especially its process is acknowledged after relevant literatures are reviewed. The potential of using microanalysis in examining the deinstitutionalisation process is demonstrated. The sensemaking perspective is thus used to facilitate this processual research. Findings have important implications for the theoretical development of institutional changes, sensemaking and especially deinstitutionalisation. First of all, the model and evidence sheds some light on the nature and development of the deinstitutionalisation process. Secondly, the analytic capacity of the institutional theory especially its descriptive and predictive contents are tested in the context of evolving institutions. The relative strengths of regulative, cognitive and normative influences in non-conventional cultural and institutional contexts extend our knowledge of institutional change and effects. Using sensemaking perspective, the findings also demonstrate the role and power of resistance during institutional processes and explain the possibility of multiple paces and outcomes within a single deinstitutionalisation process. As for sensemaking, crisis sensemaking will be examined in a new context: disaster-struck but not life-threatening. In practical terms, this study is carried out in an organisational context therefore it has relevant managerial implications.

  3. The impact of living arrangements and deinstitutionalisation in the health status of persons with intellectual disability in Europe

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    Martínez-Leal, R.; Salvador-Carulla, L.; Linehan, C.; Walsh, P.; Weber, G.; Van Hove, G.; Määttä, T.; Azema, B.; Haveman, M.; Buono, S.; Germanavicius, A.; van Schrojenstein Lantman-de Valk, H.; Tossebro, J.; Carmen-Câra, A.; Moravec Berger, D.; Perry, J.; Kerr, M.

    2011-01-01

    Background Despite progress in the process of deinstitutionalisation, very little is known about the health conditions of people with intellectual disability (PWID) who live in large institutions and PWID living in small residential services, family homes or independent living within the community. Furthermore, there are no international comparison studies at European level of the health status and health risk factors of PWID living in fully staffed residential services with formal support and care compared with those living in unstaffed family homes or independent houses with no formal support. Methods A total of 1269 persons with ID and/or their proxy respondents were recruited and face-to-face interviewed in 14 EU countries with the P15, a multinational assessment battery for collecting data on health indicators relevant to PWID. Participants were grouped according to their living arrangements, availability of formal support and stage of deinstitutionalisation. Results Obesity and sedentary lifestyle along with a number of illnesses such as epilepsy, mental disorders, allergies or constipation were highly prevalent among PWID. A significantly higher presence of myocardial infarctions, chronic bronchitis, osteoporosis and gastric or duodenal ulcers was found among participants in countries considered to be at the early stage of deinstitutionalisation. Regardless of deinstitutionalisation stage, important deficits in variables related to such medical health promotion measures as vaccinations, cancer screenings and medical checks were found in family homes and independent living arrangements. Age, number of people living in the same home or number of places in residential services, presence of affective symptoms and obesity require further attention as they seem to be related to an increase in the number of illnesses suffered by PWID. Discussion Particular illnesses were found to be highly prevalent in PWID. There were important differences between different living

  4. A Short History of Deinstitutionalisation in Slovenia

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    Vito Flaker

    2012-12-01

    Full Text Available The definition of deinstitutionalisation needs to be broader than just resettlement of the people from closed institutions into the community; it also presents a fundamental shift in the power relations of users and professionals as well as an epistemological rupture away from aprioristic and esoteric knowledge of control towards wisdom of everyday live. The process in Slovenia began in the sixties with the experiment in Logatec demonstrating that an institution can be transformed, introducing new methods of working with people based on democratic relationships, action research and experiment. An incubation period ensued in the seventies in various action research projects, most legendary being the kids summer camp in Rakitna and Črni mrav (Black Ant scouts camps, providing holidays and including children and youth with various labels in the community leisure organisations. These projects featured anti-authoritarianism, inclusion of the stigmatised, democratisation of the community by the community and group work. The goals of deinstitutionalisation – closure of the institutions and alternative provision of community services – was clearly articulated in the eighties in youth work camps in the long-stay institution of Hrastovec and in the activities of the Committee for Social Protection of Madness. First, community services – group homes, day centres and clubs, self-help and users and carers associations, but also individual planning and direct funding were introduced in the nineties in the nongovernmental sector. The real deinstitutionalisation process commenced in the first decade of this century by resettlement of the long stay inmates in Hrastovec, followed also by other long stay institutions. When deinstitutionalisation had to become a principle guiding the whole system, the process came to a halt, partly because of the lack of political will and partly because of the segmentation of the sectors and professions

  5. Optimization, an Important Stage of Engineering Design

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    Kelley, Todd R.

    2010-01-01

    A number of leaders in technology education have indicated that a major difference between the technological design process and the engineering design process is analysis and optimization. The analysis stage of the engineering design process is when mathematical models and scientific principles are employed to help the designer predict design…

  6. Deinstitutionalisation of mental health care in the Netherlands: towards an integrative approach

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    Dick P. Ravelli

    2006-03-01

    Full Text Available Objective: The objective of this policy paper is to put recent developments in Dutch mental health reform in an international perspective and draw conclusions for future directions in policy. Context of the case: The practice of Western psychiatry in the second half and particularly in the last decade of the 20th century has fundamentally changed. Dutch psychiatry has traditionally been prominently bed-based and various policies in the last ten years have been intended to reduce the influence of the mental hospitals. Until the mid-1990s, this had not resulted in reducing the psychiatric bed rate in comparison to other countries. Since then, there have been rapid, dramatic changes. Data sources: We summarised two recent national studies on this subject and placed them in a national and international context, using documents on psychiatric reforms, government and advisory board reports and reviews on deinstitutionalisation in different countries. Case description: The practice of psychiatry in the second half, and particularly in the last decade, of the 20th century has fundamentally changed. This has resulted in a spectacular decline in the number of beds in mental hospitals, increased admissions, decreased length of stay, closure of the large asylums and in community treatment away from asylums and in society, although this is a reform process. This article examines how the Dutch mental health care system has developed at the national level. The main topics cover the size, nature, aims and effects of the process of deinstitutionalisation and how alternative facilities have been developed to replace the old-fashioned institutes. Conclusions and discussion: There are two contrasting aspects of deinstitutionalisation in Dutch mental health care: the tendency towards rehospitalisation in relation to the sudden, late, but rapid reduction of the old mental hospitals and their premises; and a relatively large scale for community-based psychiatry in

  7. The Impact of Living Arrangements and Deinstitutionalisation in the Health Status of Persons with Intellectual Disability in Europe

    Science.gov (United States)

    Martinez-Leal, R.; Salvador-Carulla, L.; Linehan, C.; Walsh, P.; Weber, G.; Van Hove, G.; Maata, T.; Azema, B.; Haveman, M.; Buono, S.; Germanavicius, A.; van Schrojenstein Lantman-de Valk, H.; Tossebro, J.; Carmen-Cara, A.; Berger, D. Moravec; Perry, J.; Kerr, M.

    2011-01-01

    Background: Despite progress in the process of deinstitutionalisation, very little is known about the health conditions of people with intellectual disability (PWID) who live in large institutions and PWID living in small residential services, family homes or independent living within the community. Furthermore, there are no international…

  8. The impact of living arrangements and deinstitutionalisation in the health status of persons with intellectual disability in Europe.

    NARCIS (Netherlands)

    Martinez-Leal, R.; Salvador-Carulla, L.; Linehan, C.; Walsh, P.; Weber, G.; Hove, G. van; Maatta, T.; Azema, B.; Haveman, M.; Buono, S.; Germanavicius, A.; Schrojenstein Lantman, H.M.J. van; Tossebro, J.; Carmen-Cara, A.; Moravec Berger, D.; Perry, J.; Kerr, M.

    2011-01-01

    BACKGROUND: Despite progress in the process of deinstitutionalisation, very little is known about the health conditions of people with intellectual disability (PWID) who live in large institutions and PWID living in small residential services, family homes or independent living within the community.

  9. Deinstitutionalising school science: Implications of a strong view of situated cognition

    Science.gov (United States)

    Roth, Wolff-Michael; McGinn, Michelle K.

    1997-12-01

    Psychological models of learning have been shaped by information processing models for four decades. These models have led to teaching models based on information transfer from teachers to students. However, recent research in many fields shows that information processing models do not account for much of human competence in everyday scientific and lay contexts. At the same time, situated cognition models have been developed that better account for competence in widely differing situations. The implications of situated cognition are rather different from those of information processing. Teaching and learning are no longer conceived simply in terms of information transfer but as increasing participation in everyday practices. Conceiving of science learning as a trajectory of increasing participation asks educators to rethink the purpose of science education from preparing scientists to preparing citizens to participate in public enactments of science, and this entails deinstitutionalising school science to take science beyond the classroom walls.

  10. Early Stage of Hypertensive Retinopathy; Is It Really Important?

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    Murat KARAMAN

    2014-09-01

    Full Text Available OBJECTIVE: To investigate the relationship between early stage hypertensive retinopathy (HTRP and endothelial dysfunction (ED in atherogenesis. MATERIAL and METHODS: A total of 99 subjects consisting of 73 patients diagnosed with Essential Hypertension (HT and 26 healthy subjects were included to the study. Flow mediated dilatation (FMD was performed to detect ED. Asymmetric dimethylarginine-ADMA was measured as a marker of ED and the hsCRP and sTWEAK levels were measured for microvascular inflammation. All patients were screened for retinopathy. RESULTS: The mean blood pressure of the hypertensive patients and the control subjects was 140.1±13.7/86.1±10.7 and 107.12±10.0/65.38±10.2 respectively. HTRP was positive in 60.3% (n=44 and negative in 39.7% (n=29 of the patients with hypertension. There was grade 1 retinopathy in 52.1% and grade 2 retinopathy in 8.2% of hypertensive patients. The hsCRP, sTWEAK and ADMA levels were significantly higher in hypertensive patients than in the control group (respectively, p=0,011, p=0,001, p=0,001. FMD levels were lower in the hypertensive group, as expected. FMD levels were lower in the retinopathy group when the hypertensive group with and without retinopathy and the control group compared. hsCRP, sTWEAK and ADMA levels were significantly higher in subjects with retinopathy. hsCRP, sTWEAK and ADMA levels were also significantly higher in subjects with retinopathy (p=0.039, p=0.001, p=0.001. CONCLUSION: ED is thought to play a role in HT etiology and is also important in the development of HT complications. It would be appropriate to evaluate hypertensive patients more carefully and perform the necessary laboratory tests to detect ED so that the proper treatment can be started (ACEI, exercise, lifestyle changes.

  11. Breast cancer stage at diagnosis: is travel time important?

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    Henry, Kevin A; Boscoe, Francis P; Johnson, Christopher J; Goldberg, Daniel W; Sherman, Recinda; Cockburn, Myles

    2011-12-01

    Recent studies have produced inconsistent results in their examination of the potential association between proximity to healthcare or mammography facilities and breast cancer stage at diagnosis. Using a multistate dataset, we re-examine this issue by investigating whether travel time to a patient's diagnosing facility or nearest mammography facility impacts breast cancer stage at diagnosis. We studied 161,619 women 40 years and older diagnosed with invasive breast cancer from ten state population based cancer registries in the United States. For each woman, we calculated travel time to their diagnosing facility and nearest mammography facility. Logistic multilevel models of late versus early stage were fitted, and odds ratios were calculated for travel times, controlling for age, race/ethnicity, census tract poverty, rural/urban residence, health insurance, and state random effects. Seventy-six percent of women in the study lived less than 20 min from their diagnosing facility, and 93 percent lived less than 20 min from the nearest mammography facility. Late stage at diagnosis was not associated with increasing travel time to diagnosing facility or nearest mammography facility. Diagnosis age under 50, Hispanic and Non-Hispanic Black race/ethnicity, high census tract poverty, and no health insurance were all significantly associated with late stage at diagnosis. Travel time to diagnosing facility or nearest mammography facility was not a determinant of late stage of breast cancer at diagnosis, and better geographic proximity did not assure more favorable stage distributions. Other factors beyond geographic proximity that can affect access should be evaluated more closely, including facility capacity, insurance acceptance, public transportation, and travel costs.

  12. Leadership in the world of the Bible: (Deinstitutionalisation as an ongoing process

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    Y. Dreyer

    2002-08-01

    Full Text Available This article discusses the development of leadership in the biblical world in light of structuration theory. The use of the structuration theory is embedded in the theoretical work of Max Weber. Max Weber distinguishes three types of authority: legal, traditional and charismatic authority. In order to differentiate between the more nurturing and the more institutionalised aspects of authority (with the innate possibility of the abuse of power, Latin, rather than Western languages, provides the most useful terminology. The article traces the development from auctoritas (nurturing authority to potestas (coercive power. It focuses on how authority manifested in the Near- and Middle-East, the Hellenistic Emperor Cult and early Christianity. The aim is to explain the ways in which power and authority function in society by reflecting on the development from charismatic to institutionalised leadership. The potential danger that the message of Jesus can be adapted to the power structures of the world, is highlighted. Deinstitutionalisation is a postmodern demystifying process, by means of which church and society can be restructured today.

  13. Mental health care delivery system reform in Belgium: the challenge of achieving deinstitutionalisation whilst addressing fragmentation of care at the same time.

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    Nicaise, Pablo; Dubois, Vincent; Lorant, Vincent

    2014-04-01

    Most mental health care delivery systems in welfare states currently face two major issues: deinstitutionalisation and fragmentation of care. Belgium is in the process of reforming its mental health care delivery system with the aim of simultaneously strengthening community care and improving integration of care. The new policy model attempts to strike a balance between hospitals and community services, and is based on networks of services. We carried out a content analysis of the policy blueprint for the reform and performed an ex-ante evaluation of its plan of operation, based on the current knowledge of mental health service networks. When we examined the policy's multiple aims, intermediate goals, suggested tools, and their articulation, we found that it was unclear how the new policy could achieve its goals. Indeed, deinstitutionalisation and integration of care require different network structures, and different modes of governance. Furthermore, most of the mechanisms contained within the new policy were not sufficiently detailed. Consequently, three major threats to the effectiveness of the reform were identified. These were: issues concerning the relationship between network structure and purpose, the continued influence of hospitals despite the goal of deinstitutionalisation, and the heterogeneity in the actual implementation of the new policy. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  14. International importance of the eastern Chukchi Sea as a staging area for migrating king eiders

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    Oppel, S.; Dickson, D.L.; Powell, A.N.

    2009-01-01

    The evaluation of habitats used by arctic birds on migration is crucial for their conservation. We explored the importance of the eastern Chukchi Sea (ECS) as a staging area for king eiders (Somateria spectabilis) migrating between breeding areas in Siberia and western North America and wintering areas in the Bering Sea. We tracked 190 king eiders with satellite transmitters between 1997 and 2007. In late summer, 74% of satellite-tracked king eiders migrating south staged in the ECS for 13 ?? 13 (SD) days between late June and early November. During spring migration, king eiders staged in the ECS between mid-April and early June for 21 ?? 10 days. All instrumented birds migrating to breeding grounds in western North America (n = 62), and 6 of 11 males migrating to breeding grounds in Siberia, used this area for at least 1 week during spring migration. The importance of this staging area renders it possible that industrial development could adversely affect king eider populations in both Siberia and North America. ?? 2009 US Government.

  15. DNA barcoding identifies all immature life stages of a forensically important flesh fly (Diptera: Sarcophagidae).

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    Meiklejohn, Kelly A; Wallman, James F; Dowton, Mark

    2013-01-01

    Carrion-breeding insects, such as flesh flies (Diptera: Sarcophagidae), can be used as evidence in forensic investigations. Despite their considerable forensic potential, their use has been limited because morphological species identification, at any life stage, is very challenging. This study investigated whether DNA could be extracted and cytochrome oxidase subunit I (COI) barcode sequences obtained for molecular identification of each immature life stage of the forensically important Australian flesh fly, Sarcophaga (Sarcorohdendorfia) impatiens (Walker). Genomic DNA extracts were prepared from all larval instars and puparia. Amplification of the barcoding region was successful from all extracts, but puparia amplicons were weak. All sequences were identified as S. impatiens with 99.95% confidence using the Barcoding of Life Database (BOLD). Importantly, crop removal was necessary to eliminate PCR inhibition for specimens from late second and early third instars. Similar results are expected for immatures of other carrion-breeding species, enhancing the use of evidence from immature flies in forensic investigations.

  16. DNA extraction and barcode identification of development stages of forensically important flies in the Czech Republic.

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    Olekšáková, Tereza; Žurovcová, Martina; Klimešová, Vanda; Barták, Miroslav; Šuláková, Hana

    2017-03-21

    Several methods of DNA extraction, coupled with 'DNA barcoding' species identification, were compared using specimens from early developmental stages of forensically important flies from the Calliphoridae and Sarcophagidae families. DNA was extracted at three immature stages - eggs, the first instar larvae, and empty pupal cases (puparia) - using four different extraction methods, namely, one simple 'homemade' extraction buffer protocol and three commercial kits. The extraction conditions, including the amount of proteinase K and incubation times, were optimized. The simple extraction buffer method was successful for half of the eggs and for the first instar larval samples. The DNA Lego Kit and DEP-25 DNA Extraction Kit were useful for DNA extractions from the first instar larvae samples, and the DNA Lego Kit was also successful regarding the extraction from eggs. The QIAamp DNA mini kit was the most effective; the extraction was successful with regard to all sample types - eggs, larvae, and pupari.

  17. Managing de-institutionalisation in a context of change: The case of ...

    African Journals Online (AJOL)

    Adele

    importance of easy access to and adequate numbers of acute ... reality of Gauteng, these experiences contain lessons for others engaged in policy making and planning in this ... governmental organizations, particularly if (however good their.

  18. Deinstitutionalisation in the Netherlands

    NARCIS (Netherlands)

    Pijl, YJ; Kluiter, H; Wiersma, D

    2001-01-01

    In the Netherlands mental hospitals and psychiatric departments in general hospitals kept the initiative in implementing community-based replacements for inpatient care. The goal of this study is to determine to what extent day treatment, sheltered residences and assertive home treatment were effect

  19. The Russian-French Agreement on Mutual Qualifications Cecognition - an Important Stage of International Educational Cooperation

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    Gennady Fedorovich Tkach

    2016-12-01

    Full Text Available The article considers the historical background, organizational and legal circumstances of the development and signing of the Russian-French agreement on mutual recognition of education and (or qualifications and degrees. The authors reveal fundamental importance of the uniform approach by comparison the basic levels of education between the two countries and the relevant qualifications. Analysis of the main substantive provisions of the joint document is provided. It is the first such full-scale agreement signed by the Russian Federation with one of the developed countries. A brief overview of the evolution of “qualifications recognition”, its concept, essence, targets and terminology are given in the initial part of the paper. The article analyzes the definitions of terms used both in the Convention on the Recognition of Qualifications concerning Higher Education in the European region and in the modern practice of the recognition of the Russian Federation. Distinction of the purpose and possibilities of conventions application and bilateral agreements on the recognition of qualifications are shown. The authors describe the sequence and content of the basic stages of development of the draft Agreement. The article displays mismatch of the two countries on the possibility of professional recognition along with academic recognition. In conclusion, the authors express confidence that the signing of the Russian-French agreement on the recognition of qualifications will promote academic exchanges and deepen cooperation between Russia and France, and will have a stimulating effect on all aspects of international educational co-operation between Russia and other countries.

  20. Prognostic importance of VEGF-A haplotype combinations in a stage II colon cancer population

    DEFF Research Database (Denmark)

    Kjaer-Frifeldt, Sanne; Fredslund, Rikke; Lindebjerg, Jan;

    2012-01-01

    To investigate the prognostic effect of three VEGF-A SNPs, -2578, -460 and 405, as well as the corresponding haplotype combinations, in a unique population of stage II colon cancer patients.......To investigate the prognostic effect of three VEGF-A SNPs, -2578, -460 and 405, as well as the corresponding haplotype combinations, in a unique population of stage II colon cancer patients....

  1. Hemicrania continua in a black patient--the importance of the non-continuous stage.

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    Joubert, J

    1991-07-01

    A 52-year-old black female for 19 years had severe intermittent unilateral headaches that demonstrated the "clustering" phenomenon. She was initially diagnosed as having episodic cluster headache. Response to lithium carbonate, ergotamine and courses of corticosteroids was, however, only partial. In December 1989 the headache pattern changed and she developed severe unilateral hemicranial headache that was continuous and non-remitting. This responded immediately and persistently to oral indomethacin. A diagnosis of hemicrania continua (HC) was made. The initial intermittent headache syndrome appears to have been the pre-continuous stage of hemicrania continua, and not episodic cluster headache as previously supposed. The pre-continuous phase of hemicrania continua may thus masquerade as episodic cluster headache by reason of its intermittency and "clustering". In this case, the intermittent stage was protracted. This stage may, conceivably, even be a permanent one. To our knowledge, this is the first report of hemicrania continua in a black African.

  2. Palliative Care for a Mentally Incompetent End Stage Renal Failure Patient: Why Is It Important?

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    Kwok-Ying Chan

    2015-01-01

    Full Text Available People with intellectual disabilities are among the most disadvantaged groups in society. Here we report a mentally incompetent end stage renal failure (ESRF patient with frequent emergency visits who made a significant improvement in symptoms control and reduction in casualty visits after introduction of renal palliative care service. Multidisciplinary approach would be useful in this case.

  3. Dicer is selectively important for the earliest stages of erythroid development

    DEFF Research Database (Denmark)

    Buza-Vidas, Natalija; Cismasiu, Valeriu B; Moore, Susan

    2012-01-01

    MicroRNAs (miRs) are involved in many aspects of normal and malignant hematopoiesis, including hematopoietic stem cell (HSC) self-renewal, proliferation, and terminal differentiation. However, a role for miRs in the generation of the earliest stages of lineage committed progenitors from HSCs has ...

  4. Determination of Some Ethnomedicinally Important Constituents of Aegle marmelos Fruit During Different Stages of Ripening

    Institute of Scientific and Technical Information of China (English)

    Nisha Yadav; Parul Singh; Ranjana Mehrotra

    2011-01-01

    AIM: Aegle marmelos is a medicinal herb belonging to the Rutacae family. The fruit of A. marmelos at each stage of ripening is used as ethnomedicine to cure various diseases. The aim of the present study was to determine the components contributing to the medicinal value of the A. marmelos fruit at different stages of ripening. METHODS: High-performance liquid chromatography (HPLC) was used to determine polyphenol, vitamins, organic acids and sugars in A. marmelos fruit at different stages of ripening. RESULTS: Tannin, a polyphenol responsible for astringent and antimicrobial properties of A. marmelos fruit was found to increase during ripening. Riboflavin, a vital medicinal component was detected in traceable amount only in full-ripe A. marmelos fruit. Ribofla-vin contributes towards body growth, reproduction and red cell production. The content of ascorbic acid (vitamin C) which is useful in preventing scurvy decreased significantly as fruit ripens. CONCLUSIONS: The difference in the medicinal effect of A. marmelos fruit at each stage of ripening might be due to the presence of different amount of polyphenol, vitamins and organic acids.

  5. The importance of adjuvant chemotherapy and pelvic radiotherapy in high-risk early stage endometrial carcinoma.

    Science.gov (United States)

    Jutzi, Leah; Hoskins, Paul; Lim, Peter; Aquino-Parsons, Christina; Tinker, Anna; Kwon, Janice S

    2013-12-01

    To determine the impact of a policy change in which women with high-risk early stage endometrioid endometrial cancer (EEC) received adjuvant chemoradiotherapy. This is a population-based retrospective cohort study of British Columbia Cancer Registry patients diagnosed from 2008 to 2012 with high-risk early stage EEC, who received adjuvant chemoradiotherapy after primary surgery. High-risk early stage was defined as the presence of two or more high-risk uterine factors: grade 3 tumor, more than 50% myometrial invasion, and/or cervical stromal involvement. Adjuvant therapy consisted of 3 or 4 cycles of carboplatin and paclitaxel chemotherapy, followed by pelvic radiotherapy. Sites and rate of recurrence were compared to a historical cohort diagnosed from 2005 to 2008 in which none of the patients received adjuvant chemoradiotherapy. Five-year progression-free and overall survival rates were calculated. The study includes 55 patients. All patients except for 2 received at least 3 cycles of chemotherapy. All patients received pelvic radiotherapy except for 2 who received brachytherapy only. Median follow-up was 27 months (7-56 months). Four patients (7.3%) recurred, including three with distant recurrence only and one with both a pelvic and paraaortic nodal recurrence. The historical cohort had a 29.4% recurrence rate, and therefore the hazard ratio for recurrence was 0.27 (95% CI 0.02-4.11). Five-year progression-free and overall survival rates were 88.6% and 97.3%, respectively. Patients with high-risk early stage endometrial carcinoma treated with adjuvant chemoradiotherapy have a low rate of recurrence compared to those not receiving such therapy. © 2013.

  6. Individualization of psychological training and its importance at different stages of many years’ perfection in tennis

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    Vysochina N.L.

    2015-08-01

    Full Text Available Purpose: to determine significance of individualized approach during psychological training at different stages of many years’ perfection in tennis. The tasks of the research were studying of place and role of psychological component in general system of tennis players’ sport training as well as determination of specificities of individualized approach during 14-15 years old and elite tennis players’ psychological training. Material: In the research 24 experts, coaches of combined teams and clubs, elite tennis players took part. Results: Role of psychological training in general system of many years’ perfection has been determined. We also found out that individualization of psychological training in modern tennis is not paid sufficient attention to at present. Most of the questioned respondents pointed, that such training is conducted mainly with elite sportsmen (42%. Only 14% noted that individual psychological training is carried out at basic stages of many years’ perfection. Conclusions: Principle of individualization is a determining one in the course of sportsmen’s training at stages of many years’ perfection. About 86% of experts stressed on significance of application of individualized approach in work with tennis players. Consideration of tennis players’ individual features during psychological training is a compulsory matter in increasing of effectiveness of sportsmen’s training and competition functioning.

  7. LIVER BIOPSY: IMPORTANCE OF SPECIMEN SIZE IN THE DIAGNOSIS AND STAGING OF CHRONIC VIRAL HEPATITIS

    Science.gov (United States)

    CORAL, Gabriela P.; ANTUNES, Aline Dal Pozzo; SERAFINI, Ana Paula Almeida; ARAUJO, Fernanda B.; de MATTOS, Angelo Alves

    2016-01-01

    Liver biopsy is the gold standard method for the grading and staging of chronic viral hepatitis, but optimal biopsy specimen size remains controversial. The aim of this study was to evaluate the quality of liver specimen (number of portal tracts) and to evaluate the impact of the number of portal tracts in the staging of chronic hepatitis. Material and Methods: 468 liver biopsies from consecutive patients with hepatitis C virus and hepatitis B virus infection from 2009 to 2010 were evaluated. Results: The length of fragment was less than 10 mm in 43 cases (9.3%), between 10 and 14 mm in 114 (24.3%), and ≥ 15 mm in 311 (64.4%); of these, in 39 (8.3%) cases were ≥ 20 mm. The mean representation of portal tracts was 17.6 ± 2.1 (5-40); in specimens ≥ 15 mm the mean portal tract was 13.5 ± 4.7 and in cases ≤ 15 mm was 11.4 ± 5.0 (p = 0.002). Cases with less than 11 portal tracts were associated with F3, and cases with 11 or more portal tracts with F2 (p = 0.001). Conclusion: this study demonstrated the good quality of liver biopsy and a relationship between the macroscopic size of the fragment and the number of portal tracts. PMID:26910447

  8. LIVER BIOPSY: IMPORTANCE OF SPECIMEN SIZE IN THE DIAGNOSIS AND STAGING OF CHRONIC VIRAL HEPATITIS

    Directory of Open Access Journals (Sweden)

    Gabriela P. CORAL

    2016-01-01

    Full Text Available Liver biopsy is the gold standard method for the grading and staging of chronic viral hepatitis, but optimal biopsy specimen size remains controversial. The aim of this study was to evaluate the quality of liver specimen (number of portal tracts and to evaluate the impact of the number of portal tracts in the staging of chronic hepatitis. Material and Methods: 468 liver biopsies from consecutive patients with hepatitis C virus and hepatitis B virus infection from 2009 to 2010 were evaluated. Results: The length of fragment was less than 10 mm in 43 cases (9.3%, between 10 and 14 mm in 114 (24.3%, and ≥ 15 mm in 311 (64.4%; of these, in 39 (8.3% cases were ≥ 20 mm. The mean representation of portal tracts was 17.6 ± 2.1 (5-40; in specimens ≥ 15 mm the mean portal tract was 13.5 ± 4.7 and in cases ≤ 15 mm was 11.4 ± 5.0 (p = 0.002. Cases with less than 11 portal tracts were associated with F3, and cases with 11 or more portal tracts with F2 (p = 0.001. Conclusion: this study demonstrated the good quality of liver biopsy and a relationship between the macroscopic size of the fragment and the number of portal tracts.

  9. Schistosome elastases: biological importance, structure, function and stage-specific expression.

    Science.gov (United States)

    Newport, G; McKerrow, J; Hedstrom, R; Culpepper, J; McGarrigle, L; Agabian, N

    1987-01-01

    Larval schistosomes (Digenea: Trematoda) invade their definitive host by directly penetrating the skin. During the process they secrete a number of macromolecules, ostensibly to facilitate their entry. Among these we have identified and characterized a dominant proteolytic species: a serine protease capable of fragmenting keratin, types IV and VIII collagen, proteoglycan, fibronectin, laminin, and elastin. The enzyme exhibits the specificity characteristic of elastases, has a molecular mass of 30,000 Da and pI of 7.8, and is potently immunogenic in its native form. Specificity of the active site has been analysed, tetrapeptides having large hydrophobic or aromatic amino acids at size P1 serving as best substrates. The amino terminal 20 amino acids of the mature enzyme have been sequenced and the information derived has been used to construct an oligonucleotide (22-mer) complement of its corresponding mRNA. The latter has been used to establish, by Northern analysis, that expression of the enzyme is stage specific (differing in this respect from most schistosome immunogens), and under transcriptional control. Transcripts are encoded by a multigene family. Several cDNAs hybridizing to the oligonucleotide have been isolated, subcloned into bacteriophage M-13, and sequenced by the di-deoxy method. It is our expectation that this line of investigation will lead towards: (i) an anti-infection vaccine; (ii) a means for chemically preventing infection (using enzyme inhibitors), and/or (iii) a rapid diagnostic assay of prepatent infection.

  10. Staging a mock trial: educating nurses on the importance of documenting critical values.

    Science.gov (United States)

    Troxel, Dyan

    2012-01-01

    For nurse educators teaching about policies, choosing an interactive approach is vital. One such method is a mock trial. This article describes the process to present a mock trial to emphasize the importance of documenting critical values. This strategy emphasizes learner participation and offers a real-life scenario in a safe, simulated environment. © 2012 AWHONN.

  11. Is multislice computed tomography an important tool for breast cancer staging and follow-up?

    Energy Technology Data Exchange (ETDEWEB)

    Miranda, Christiana Maia Nobre Rocha de; Santos, Carla Jotta Justo dos; Maranhao, Carol Pontes de Miranda, E-mail: maiachristiana@globo.com [Clinica de Medicina Nuclear e Radiologia de Maceio (MedRadiUS), Maceio, AL (Brazil); Farias, Lucas de Padua Gomes de; Padilha, Igor Gomes; Andrade, Anna Carolina de Mendonca de; Jatoba, Mayara Stephanie de Araujo [Faculdade de Medicina da Universidade Federal de Alagoas, Maceio, AL (Brazil)

    2012-03-15

    Breast cancer is the most common cancer in women and the leading cause of cancer death among the female population. Extramammary findings related to breast cancer play an important role in the prognosis and treatment of such entity and the correct diagnosis of such alterations is essential for increasing the chance of cure. Most of the times, such manifestations result from complications arising from treatment, and may be associated with lymph node involvement, locoregional recurrence or distant metastasis. (author)

  12. Each life stage matters: the importance of assessing the response to climate change over the complete life cycle in butterflies.

    Science.gov (United States)

    Radchuk, Viktoriia; Turlure, Camille; Schtickzelle, Nicolas

    2013-01-01

    As ectothermic organisms, butterflies have widely been used as models to explore the predicted impacts of climate change. However, most studies explore only one life stage; to our best knowledge, none have integrated the impact of temperature on the vital rates of all life stages for a species of conservation concern. Besides, most population viability analysis models for butterflies are based on yearly population growth rate, precluding the implementation and assessment of important climate change scenarios, where climate change occurs mainly, or differently, during some seasons. Here, we used a combination of laboratory and field experiments to quantify the impact of temperature on all life stages of a vulnerable glacial relict butterfly. Next, we integrated these impacts into an overall population response using a deterministic periodic matrix model and explored the impact of several climate change scenarios. Temperature positively affected egg, pre-diapause larva and pupal survival, and the number of eggs laid by a female; only the survival of overwintering larva was negatively affected by an increase in temperature. Despite the positive impact of warming on many life stages, population viability was reduced under all scenarios, with predictions of much shorter times to extinction than under the baseline (current temperature situation) scenario. Indeed, model predictions were the most sensitive to changes in survival of overwintering larva, the only stage negatively affected by warming. A proper consideration of every stage of the life cycle is important when designing conservation guidelines in the light of climate change. This is in line with the resource-based habitat view, which explicitly refers to the habitat as a collection of resources needed for all life stages of the species. We, therefore, encourage adopting a resource-based habitat view for population viability analysis and development of conservation guidelines for butterflies, and more generally

  13. Ultrastructure of immature stages of Cochliomyia macellaria (Diptera: Calliphoridae), a fly of medical and veterinary importance.

    Science.gov (United States)

    Mendonça, Paloma Martins; Barbosa, Rodrigo Rocha; Cortinhas, Lucas Barbosa; dos Santos-Mallet, Jacenir Reis; de Carvalho Queiroz, Margareth Maria

    2014-10-01

    Cochliomyia macellaria (Diptera: Calliphoridae) is known as the secondary screwworm because it causes secondary or facultative myiasis when the larvae feed on necrotic tissues. This fly has a significant medical and veterinary importance since it has been reported to transport eggs of Dermatobia hominis (human botfly), which can cause significant economic losses to livestock. Since this screwworm has been collected colonizing both pig carcasses and human cadavers, it is considered one of the most important species for forensic entomology studies. Scanning electron microscopy (SEM) gives detailed information on the morphological characteristics which can help identify the immature forms of the flies. The aim of this study was to describe and analyze the morphological characteristics of the eggs, all the larval instars, and the puparia of Cochliomyia macellaria using SEM. The egg is ellipsoid and the dorsal surface is concave. The islands inside the median area had no anastomosis, but some perforations could be observed. From the second larval instar onwards, besides the intersegmental spines, other bands of spines were observed at the abdominal segments. Two spiracular openings were visible on the first and second larval instars, which were not expected. These characteristics are specific to Cochliomyia genus. The number and the general aspect of the spine tips in the cephalic region, the intersegmental bands on the abdomen, and the number of the spiracular openings could together help identify C. macellaria.

  14. The relative importance of genetic and environmental effects for the early stages of thyroid autoimmunity

    DEFF Research Database (Denmark)

    Hansen, Pia S; Brix, Thomas H; Iachine, Ivan;

    2006-01-01

    OBJECTIVE: In euthyroid individuals, autoantibodies to thyroid peroxidase (TPOab) and thyroglobulin (Tgab) are regarded as early markers of thyroid autoimmunity. Family and twin studies suggest that development of thyroid autoantibodies in first-degree relatives of patients with autoimmune thyroid...... disease is under genetic influence. We aimed to estimate the relative importance of genetic and environmental effects for the presence of thyroid autoantibodies in euthyroid subjects. METHODS: A representative sample of healthy twin pairs was identified through the Danish Twin Registry; 1372 individuals...... concordance and intraclass correlations were consistently higher for MZ than for DZ twin pairs indicating genetic influence. Genetic components (with 95% confidence intervals) accounted for 73% (46-89%) of the liability of being thyroid antibody positive. Adjusting for covariates (age, TSH and others...

  15. The Importance of Preoperative Staging of Rectal Cancer Using Multiparametric MRI. A Systematic Review

    Science.gov (United States)

    Bauer, Ferdinand

    2016-01-01

    A correct preoperative stadialization of rectal carcinoma has a direct influence upon its therapeutic strategy, resulting in a significant improvement of the survival rate and life quality after the treatment. The therapeutic strategy refers to the option of undergoing or not preoperative radiochemotherapy before the total mesorectal excision (TME). The technical advances in the magnetic resonance domain makes possible the multiparametric examinations (mp MRI) with medical equipments (3T models are common) good enough to obtain images having an excellent quality, which allow a correct diagnosis of the local tumour spread. These multiparametric examinations include T2 multiplan sequences and T1 sequences, which offer valuable morphological information due to the high resolution of anatomic structures and DWI functional sequences, with a decisive role in tracing residual tumours after post-surgery radiochemotherapy. The functional examination using DWI is the only highly accurate non-invasive diagnostic method which can differentiate the fibrosis from vital tumoral remnants. The dynamic contrast-enhanced examination (DCE) combined with DWI and volumetry can give supplementary information as to the complete and incomplete response to RCT, and is efficient in detecting a local recurrence after TME. Also, MRI is the only diagnostic method which has the necessary accuracy to assess the meso-rectal fascia, which represents the circumferential resection margin (CRM) in the case of TME. With the help of MRI we can measure with a precision similar to histology the minimal distance to the mesorectal fascia, essential in planning the surgical treatment, and more important than the T stadialization. This allows the selection of patients with an unfavourable prognosis factor who would benefit from radiotherapy or from RCT. The evaluation of other prognostic factors as the condition of nodes, their number and primary site, and the extramural venous invasion (EMVI) have an

  16. Micromorphology of immature stages of Sarcophaga (Liopygia) cultellata Pandellé, 1896 (Diptera: Sarcophagidae), a forensically important fly.

    Science.gov (United States)

    Ubero-Pascal, Nicolás; Paños, Ángela; García, María-Dolores; Presa, Juan-José; Torres, Belén; Arnaldos, María-Isabel

    2015-02-01

    The Sarcophagidae are one of the most numerous groups of Diptera in the world, consisting of many species of forensic interest, whose immature stages are useful in the estimation of postmortem interval. The immature stages of some species of forensic importance still remain unknown or undescribed, like in the case of Sarcophaga (Liopygia) cultellata Pandellé, 1986, a species restricted to the Iberian Peninsula, south of France and north of Italy, which shares a ecological niche with species of the same subgenus, e.g., Sarcophaga (Liopygia) argyrostoma (Robineau-Desvoidy, 1830) and Sarcophaga (Liopygia) crassipalpis Macquart, 1839, making it necessary to lay the groundwork for a proper specific differentiation before it can be successfully applied in forensic practice. This study provides the first micromorphological description of all preimaginal stages of S. (L.) cultellata using light microscopy and scanning electron microscopy (SEM), the results of which allow the morphology of the main features to be followed during the immature life cycle. We propose a combination of features for distinguishing Liopygia from other sarcophagid subgenera, based on the current level of morphological knowledge of immature stages. S. (L.) cultellata can be differentiated from S. (L.) argyrostoma and S. (L.) crassipalpis in every immature stage by both light microscopy and SEM. The presence of tegumental warts and a fan-shaped anterior spiracle with a single row of 15-18 respiratory papillae allow distinguishing the third instar larvae of S. (L.) cultellata from other Sarcophaga species described hitherto by SEM. Identification keys based on light microscopy observations are provided, covering all the immature stages of Liopygia subgenus occurring in the Iberian Peninsula.

  17. Does the relative importance of resource competition and architectural effect in floral variation vary with stages of floral ontogeny?

    Institute of Scientific and Technical Information of China (English)

    Chang-Qiu LIU; Shuang-Quan HUANG

    2012-01-01

    Variation in floral allocation within inflorescences has been attributed to resource competition and/or architectural effect.The two hypotheses were extensively studied and both hypotheses were partly supported by previous studies.However,the relative importance of resource competition and architectural effect may vary with stages of floral ontogeny in a species.To detect the effects ofontogenetic stages on floral variation,we manipulated the 6-flowered inflorescences ofAdenophorajasionifolia (Campanulaceae) by early,late,and non-thinning flowers.Our results indicated that pollen and ovule production of the remaining flowers were not significantly different between early and late thinning manipulations,suggesting that floral sex allocation was determined far before flowering,in support of the architectural effect hypothesis.Under hand-pollination treatments,early thinning but not late thinning resulted in a significant increase in seed number and seed set of the remaining flowers.Therefore,the increase in seed production of the remaining flowers related to the floral ontogeny.The resource competition for floral allocation was significant under early thinning rather than late thinning manipulation.Our results suggest that studies on floral variation within inflorescences should take into account the stages of floral ontogeny.

  18. [Standard legal regulation and creation of a law code as the most important stage of public health reformation].

    Science.gov (United States)

    Gerasimenko, N F; Grigor'ev, Iu I

    2002-01-01

    The significance of a law-making process is substantially increasing under the conditions of intensified expansion of the scope of standard legal regulation in the field of human health care in the Russian Federation. The authors state that any law-making process should begin with the definition of the subject-matter of a future law, its role and value in medical law creation and also indicate that the choice of the subject-matter of a future law is of priority and the most important stage of its preparation from the points of both contents-rich and standard legal views. Moreover, the paper presents main groups of issues that can determine the subjects of sociomedical laws and states the basic rules how reflect systemic relations in legislation. The paper shows it important to create a code of laws in the field of health protection for legal assurance of health public reforms.

  19. The importance of social dimension and maturation stage for the probabilistic maturation reaction norm in Poecilia reticulata.

    Science.gov (United States)

    Diaz Pauli, B; Pauli, B D; Heino, M

    2013-10-01

    Maturation is an important event in an organism's life history, with important implications on dynamics of both wild and captive populations. The probabilistic maturation reaction norm (PMRN) has emerged as an important method to describe variation in maturation in wild fish. Because most PMRNs are based on age and size only, it is important to understand limitations of these variables in explaining maturation. We experimentally assessed (i) the sensitivity of age- and size-based PMRNs to unaccounted sources of plasticity, (ii) the role of social environment on maturation and (iii) the significance of estimating PMRNs early and late in the maturation process (initiation and completion of maturation, respectively). We reared male guppies (Poecilia reticulata) under laboratory conditions, subjected to two food levels and three different social cues. We found that growth and social environment affected the maturation in a way that could not be accounted for by their effect on age and size. PMRNs estimated for the initiation stage were less plastic (growth differences and social cues influenced the PMRN shape only little) than those for completion. The initiation of maturation is probably closer to the maturation 'decision' and allows determining factors influencing maturation decision most accurately.

  20. The prognostic importance of miR-21 in stage II colon cancer: a population-based study

    DEFF Research Database (Denmark)

    Kjaer-Frifeldt, S.; Hansen, T. F.; Nielsen, B. S.

    2012-01-01

    R-21), quantified by in situ hybridisation, in a unique, large population-based cohort. PATIENTS AND METHODS: The study included 764 patients diagnosed with stage II colon cancer in Denmark in the year 2003. One section from a representative paraffin-embedded tumour tissue specimen from each patient......-free cancer-specific survival (RF-CSS): HR = 1.26; 95% CI: 1.15-1.60; P analysis, a high level of miR-21 retained its prognostic importance and was found to be significantly related to poor RF-CSS: HR 1.41; 95% CI: 1.19-1.67; P ... was processed for analysis of miR-21 and quantitatively assessed by image analysis. RESULTS: The miR-21 signal was predominantly observed in fibroblast-like cells located in the stromal compartment of the tumours. We found that patients expressing high levels of miR-21 had significantly inferior recurrence...

  1. Post-Neogene Structural Evolution:An Important Geological Stage in the Formation of Gas Reservoirs in China

    Institute of Scientific and Technical Information of China (English)

    WANG Tingbin

    2004-01-01

    Tectonic movements since the Neogene have been the major developmental and evolutional stages of the latest global crustal deformation and orogenic movements. China is located in a triangular area bounded by the Indian landmass, the West Siberian landmass and the Pacific Plate, characterized by relatively active tectonic movements since the Neogene, and in this region, natural gas would have been very easy to dissipate, or difficult to preserve. Therefore, the characteristics of post-Neogene tectonic movements offer important geological factors in researching the formation and preservation of gas reservoirs in China. Summarizing the reservoiring history of gas fields in China, although there are some differences between various basins, they are all affected by the tectonic movements since the Neogene. These movements have certainly caused destruction to the reservoiring and distribution of natural gas in China, which has resulted in a certain dissipation of natural gas in some basins. As a whole, however, they have mainly promoted the reservoiring and accumulation of natural gas: (1) a series of China-type foreland basins have been formed between basins and ridges in western China, which provide favorable conditions for the formation of large and medium gas fields, as well as controlling the finalization of gas reservoirs in the basins; (2) rows and belts of anticlines have been formed in the Sichuan Basin in central China, which have been the major stages of the formation and finalization of gas reservoirs in that basin; the integral and quick rising and lifting, and a further west-dipping in the Ordos Basin have resulted in a further accumulation of natural gas in gas fields from Jingbian to Uxin; (3) in eastem China, the Bohai movement in the late Pliocene has provided favorable geological conditions for lately-formed gas reservoirs in the Bohai Sea area mainly composed of the Bozhong depression; and it also resulted in secondary hydrocarbon generation and

  2. Deep brain stimulation may reduce the relative risk of clinically important worsening in early stage Parkinson's disease.

    Science.gov (United States)

    Hacker, Mallory L; Tonascia, James; Turchan, Maxim; Currie, Amanda; Heusinkveld, Lauren; Konrad, Peter E; Davis, Thomas L; Neimat, Joseph S; Phibbs, Fenna T; Hedera, Peter; Wang, Lily; Shi, Yaping; Shade, David M; Sternberg, Alice L; Drye, Lea T; Charles, David

    2015-10-01

    The Vanderbilt pilot trial of deep brain stimulation (DBS) in early Parkinson's disease (PD) enrolled patients on medications six months to four years without motor fluctuations or dyskinesias. We conducted a patient-centered analysis based on clinically important worsening of motor symptoms and complications of medical therapy for all subjects and a subset of subjects with a more focused medication duration. Continuous outcomes were also analyzed for this focused cohort. A post hoc analysis was conducted on all subjects from the pilot and a subset of subjects taking PD medications 1-4 years at enrollment. Clinically important worsening is defined as both a ≥ 3 point increase in UPDRS Part III and a ≥ 1 point increase in Part IV. DBS plus optimal drug therapy (DBS + ODT) subjects experienced a 50-80% reduction in the relative risk of worsening after two years. The DBS + ODT group was improved compared to optimal drug therapy (ODT) at each time point on Total UPDRS and Part III (p = 0.04, p = 0.02, respectively, at 24 months). Total UPDRS, Part IV, and PDQ-39 scores significantly worsened in the ODT group after two years (p early PD may reduce the risk of clinically important worsening. These findings further confirm the need to determine if DBS + ODT is superior to medical therapy for managing symptoms, reducing the complications of medications, and improving quality of life. The FDA has approved the conduct of a large-scale, pivotal clinical trial of DBS in early stage PD. Copyright © 2015 Elsevier Ltd. All rights reserved.

  3. Nod-Like Receptor Protein-3 Inflammasome Plays an Important Role during Early Stages of Wound Healing

    Science.gov (United States)

    Weinheimer-Haus, Eileen M.; Mirza, Rita E.; Koh, Timothy J.

    2015-01-01

    The Nod-like receptor protein (NLRP)-3 inflammasome/IL-1β pathway is involved in the pathogenesis of various inflammatory skin diseases, but its biological role in wound healing remains to be elucidated. Since inflammation is typically thought to impede healing, we hypothesized that loss of NLRP-3 activity would result in a downregulated inflammatory response and accelerated wound healing. NLRP-3 null mice, caspase-1 null mice and C57Bl/6 wild type control mice (WT) received four 8 mm excisional cutaneous wounds; inflammation and healing were assessed during the early stage of wound healing. Consistent with our hypothesis, wounds from NLRP-3 null and caspase-1 null mice contained lower levels of the pro-inflammatory cytokines IL-1β and TNF-α compared to WT mice and had reduced neutrophil and macrophage accumulation. Contrary to our hypothesis, re-epithelialization, granulation tissue formation, and angiogenesis were delayed in NLRP-3 null mice and caspase-1 null mice compared to WT mice, indicating that NLRP-3 signaling is important for early events in wound healing. Topical treatment of excisional wounds with recombinant IL-1β partially restored granulation tissue formation in wounds of NLRP-3 null mice, confirming the importance of NLRP-3-dependent IL-1β production during early wound healing. Despite the improvement in healing, angiogenesis and levels of the pro-angiogenic growth factor VEGF were further reduced in IL-1β treated wounds, suggesting that IL-1β has a negative effect on angiogenesis and that NLRP-3 promotes angiogenesis in an IL-1β-independent manner. These findings indicate that the NLRP-3 inflammasome contributes to the early inflammatory phase following skin wounding and is important for efficient healing. PMID:25793779

  4. Nod-like receptor protein-3 inflammasome plays an important role during early stages of wound healing.

    Science.gov (United States)

    Weinheimer-Haus, Eileen M; Mirza, Rita E; Koh, Timothy J

    2015-01-01

    The Nod-like receptor protein (NLRP)-3 inflammasome/IL-1β pathway is involved in the pathogenesis of various inflammatory skin diseases, but its biological role in wound healing remains to be elucidated. Since inflammation is typically thought to impede healing, we hypothesized that loss of NLRP-3 activity would result in a downregulated inflammatory response and accelerated wound healing. NLRP-3 null mice, caspase-1 null mice and C57Bl/6 wild type control mice (WT) received four 8 mm excisional cutaneous wounds; inflammation and healing were assessed during the early stage of wound healing. Consistent with our hypothesis, wounds from NLRP-3 null and caspase-1 null mice contained lower levels of the pro-inflammatory cytokines IL-1β and TNF-α compared to WT mice and had reduced neutrophil and macrophage accumulation. Contrary to our hypothesis, re-epithelialization, granulation tissue formation, and angiogenesis were delayed in NLRP-3 null mice and caspase-1 null mice compared to WT mice, indicating that NLRP-3 signaling is important for early events in wound healing. Topical treatment of excisional wounds with recombinant IL-1β partially restored granulation tissue formation in wounds of NLRP-3 null mice, confirming the importance of NLRP-3-dependent IL-1β production during early wound healing. Despite the improvement in healing, angiogenesis and levels of the pro-angiogenic growth factor VEGF were further reduced in IL-1β treated wounds, suggesting that IL-1β has a negative effect on angiogenesis and that NLRP-3 promotes angiogenesis in an IL-1β-independent manner. These findings indicate that the NLRP-3 inflammasome contributes to the early inflammatory phase following skin wounding and is important for efficient healing.

  5. Patient-subjective cosmetic outcomes following the varying stages of tissue expander breast reconstruction: the importance of completion.

    Science.gov (United States)

    Buck, Donald W; Shenaq, Deana; Heyer, Kamaldeep; Kato, Caroline; Kim, John Y S

    2010-12-01

    Tissue expander breast reconstruction consists of three major surgical steps: placement of the expander after mastectomy, exchange of the expander for an implant, and nipple-areola complex reconstruction. The evolution of patient satisfaction throughout this process has not been evaluated. Here we performed a stratified analysis of patient-subjective cosmetic outcomes during the stages of breast reconstruction. Twenty-eight consecutive tissue expander-implant reconstructions were performed by the senior author using human acellular dermis. Cosmetic outcomes were assessed after each reconstructive stage using a validated Breast Evaluation Questionnaire consisting of questions related to breast size, shape and firmness in three separate contexts: intimate or sexual activities, leisure or social activities, and professional or job-related activities. Eighteen patients underwent unilateral reconstruction, while 10 underwent bilateral reconstruction. Satisfaction scores were statistically higher following Stage I and II procedures for bilateral reconstructions. For unilateral reconstructions, there was a statistically significant elevation in scores following Stage II. The addition of nipple-areola reconstruction resulted in the highest scores for both unilateral and bilateral reconstructions. These score elevations were significant (p reconstructions and as such, the significant differences in scores between unilateral and bilateral cohorts after stages I and II were nearly eliminated after completion of the entire reconstructive process. Satisfaction with tissue expander reconstruction is significantly affected by the patients' stage during the reconstructive process. Completion of all three stages, including nipple-areolar complex reconstruction, achieves maximal patient satisfaction. For unilateral reconstructions, completion of the entire reconstructive process, including contralateral symmetry procedures and nipple-areolar complex reconstruction, results in

  6. High tumour stage and margin clearance are still important prognostic factors for post-mastectomy locoregional recurrence in Malaysia.

    Science.gov (United States)

    Choong, Lau Peng; Taib, Nur Aishah Mohd; Rampal, Sanjay; Saad, Marniza; Bustam, Anita Zarina; Yip, Cheng-Har

    2010-01-01

    Locoregional recurrence after mastectomy for breast cancer may predict distant recurrence and mortality. This study examined the pattern and rates of post-mastectomy locoregional recurrence (PMLRR), survival outcome and prognostic factors for isolated PMLRR (ILR) in a breast cancer cohort in University of Malaya Medical Center (UMMC). We studied 522 patients who underwent mastectomy between 1998 and 2002 and followed them up until 2008. We defined PMLRR as recurrence to the axilla, supraclavicular nodes and or chest wall. ILR was defined as PMLRR occurring as an isolated event. Prognostic factors for locoregional recurrence were determined using the Cox proportional hazards regression model. The overall PMLRR rate was 16.4%. ILR developed in 42 of 522 patients (8.0%). Within this subgroup, 25 (59.5%) remained disease free after treatment while 17 (40.5%) suffered disease progression. Univariate analyses identified race, age, size, stage, margin involvement, lymph node involvement, grade, lymphovascular invasion and ER status as probable prognostic factors for ILR. Cox regression resulted in only stage III disease and margin involvement as independent prognostic factors. The hazard of ILR was 2.5 times higher when the margins were involved compared to when they were clear (aHRR 2.5; 95% CI 1.3 to 5.0). Similarly, compared with stage I those with Stage II (aHRR 2.1; 95%CI 0.6 to 6.8) and stage III (aHRR 4.6; 95%CI 1.4 to 15.9) had worse prognosis for ILR. Margin involvement and stage III disease were identified to be independent prognostic factors for ILR. Close follow-up of high risk patients and prompt treatment of locoregional recurrence were recommended.

  7. Relative importance of various regeneration mechanisms in different restoration stages of Quercus variabilis forest after selective logging

    Directory of Open Access Journals (Sweden)

    Yaoqin Xue

    2014-08-01

    Full Text Available Aim of study: Quercus variabilis (Chinese cork oak reproduces asexually and sexually. This study aimed to determine the status and growth of asexual and sexual recruits of Q. variabilis in different forest recovery stages.Area of study: Three selective logged stands and one unlogged stand in Q. variabilis forest, Shaanxi Province, China.Material and Methods: Origin, number, basal diameter, height and size structure of Q. variabilis shoots (height ≤200 cm were investigated in the plots of 5, 10, and 20-years post-logging stands and unlogged stand. Effects of recovery stage on the density and growth of the three original recruits (stump sprouts, stem base sprouts and true seedlings were analysis by One-way ANOVA.Main results: Sprouts dominated logged stands, whereas true seedlings dominated unlogged stand, stem base sprouts only existed in 20-years post-logging and unlogged stands. Stump sprout density and sprout number per stump both declined with extended post-logging time. True seedlings density increased from 7 to 20 shoots/100 m2 as the postlogging time extended, and peaked in unlogged stand (94 shoots/100 m2. An ongoing size structure was observed in true seedlings in all stands. Stump sprouts were taller and greater than true seedlings.Research highlights: Stump sprouts contributed more to Q. variabilis forest recovery in the early stage after disturbance. The contribution of true seedlings was limited in the same stage, but they were beneficial for population long-term development. Stem base sprouts were most likely to be a survival strategy rather than a reproductive strategy.Key words: asexual reproduction; true seedling; post-logging time; Chinese cork oak.

  8. Non-lethal effects of an invasive species in the marine environment: the importance of early life-history stages.

    Science.gov (United States)

    Rius, Marc; Turon, Xavier; Marshall, Dustin J

    2009-04-01

    Studies examining the effects of invasive species have focussed traditionally on the direct/lethal effects of the invasive on the native community but there is a growing recognition that invasive species may also have non-lethal effects. In terrestrial systems, non-lethal effects of invasive species can disrupt early life-history phases (such as fertilisation, dispersal and subsequent establishment) of native species, but in the marine environment most studies focus on adult rather than early life-history stages. Here, we examine the potential for an introduced sessile marine invertebrate (Styela plicata) to exert both lethal and non-lethal effects on a native species (Microcosmus squamiger) across multiple early life-history stages. We determined whether sperm from the invasive species interfered with the fertilisation of eggs from the native species and found no effect. However, we did find strong effects of the invasive species on the post-fertilisation performance of the native species. The invasive species inhibited the settlement of native larvae and, in the field, the presence of the invasive species was associated with a ten-fold increase in the post-settlement mortality of the native species, as well as an initial reduction of growth in the native. Our results suggest that larvae of the native species avoid settling near the invasive species due to reduced post-settlement survival in its presence. Overall, we found that invasive species can have complex and pervasive effects (both lethal and non-lethal) across the early life-history stages of the native species, which are likely to result in its displacement and to facilitate further invasion.

  9. Determining sensitive stages for learning to detect predators in larval bronzed frogs: Importance of alarm cues in learning

    Indian Academy of Sciences (India)

    Anuradha Batabyal; Sachin M Gosavi; Narahari P Gramapurohit

    2014-09-01

    Successful survival and reproduction of prey organisms depend on their ability to detect their potential predators accurately and respond effectively with suitable defences. Predator detection can be innate or can be acquired through learning.We studied prey–predator interactions in the larval bronzed frogs (Sylvirana temporalis), which have the innate ability to detect certain predators. We conducted a series of experiments to determine if the larval S. temporalis rely solely on innate predator detection mechanisms or can also learn to use more specific cues such as conspecific alarm cues for the purpose. The results of our study clearly indicate that larval S. temporalis use both innate and learned mechanisms for predator detection. Predator-naïve tadpoles could detect kairomones alone as a potential threat and responded by reducing activity, suggesting an innate predator detection mechanism. Surprisingly, predator-naïve tadpoles failed to detect conspecific alarm cues as a potential threat, but learned to do so through experience. After acquiring the ability to detect conspecific alarm cues, they could associate novel predator cues with conspecific alarm cues. Further, post feeding stages of larval S. temporalis are sensitive for learning to detect conspecific alarm cues to label novel predators.

  10. Ultrastructure analysis of the immature stages of Ravinia belforti (Diptera: Sarcophagidae), a species of medical-veterinary and forensic importance, by scanning electron microscopy.

    Science.gov (United States)

    da-Silva-Xavier, Alexandre; de Carvalho Queiroz, Margareth Maria

    2016-07-01

    The postmortem interval is related to the age of immature species of flies found on corpses and can be estimated using data available in the literature on the biology of the species. The flesh fly Ravinia belforti is a carrier of enteric pathogens that can affect human and animal health as well as being of forensic importance. As the morphology of many immature Sarcophagidae is unknown, these immature forms must be collected and characterized after the emergence of the adult male. Here we describe and analyze the morphological characteristics of the larvae stages L1, L2, L3 and the puparium of R. belforti by scanning electron microscopy (SEM). Ten specimens of each stage were analyzed. Larvae of R. belforti follow the typical muscoid vermiform pattern with 12 segments. The anterior region is pointed, while the posterior region is thicker. The spines of the cephalic collar are flattened and with double, triple or quadruple points, different from the spines along the body that only have a single point. In L2, the anterior spiracle is present with a varying number of papillae (16-22), differing from other species. The posterior spiracles are located within the peritreme. The spiracular cavity is internalized in the posterior region, following the pattern that differs Sarcophagidae from other families. L3 features more visible and developed spines around the cephalic collar, getting thicker and denser near to the first thoracic segment. Puparium is similar to other species of Sarcophagidae. This paper presents important data on this family which has both health and forensic importance. Furthermore, R. belforti shows significant differences from other species of Sarcophagidae. Copyright © 2016 Elsevier B.V. All rights reserved.

  11. A comparative study of triacylglycerol composition in Chinese human milk within different lactation stages and imported infant formula by SFC coupled with Q-TOF-MS.

    Science.gov (United States)

    Tu, Anqi; Ma, Qiang; Bai, Hua; Du, Zhenxia

    2017-04-15

    Triacylglycerols (TAGs) as the major component of milk fat are significant factors to ensure the healthy growth of infants. An efficient method for identifying TAGs in human milk (HM) and infant formula (IF) was established using supercritical fluid chromatograph (SFC) coupled with quadruple time-of-flight mass spectrometry (Q-TOF-MS). The results indicated the feasibility of this method with satisfactory recoveries (>80%) and correlation coefficients (r(2)⩾0.993). More than 60 TAGs in HM and 50 TAGs in IF were identified. The profiling results demonstrated that TAGs in HM were greatly affected by lactation stage. Significant differences were found between HM and IF, such as much higher medium chain TAGs and saturated TAGs in IF, indicating that the formulas developed by foreign manufacturers were not suitable for Chinese babies. This high-throughput method exhibits a huge potential for analysis of milk samples and the result may serve as an important guide for Chinese infants diet.

  12. [An important stage in the development of field therapy (on the 70th anniversary of victory in the Great Patriotic War)].

    Science.gov (United States)

    Knopov, M Sh; Taranukha, V K

    2015-01-01

    Much previous experience accumulated by physicians in various wars and local military conflicts provides strong evidence that it is necessary to set up a harmonious system to deliver therapeutic care during wartime, which is based on the unity of views on the origin, course, and treatment of pathological processes having regard to the specific conditions under which armed forces are involved in combat operations. This all has given rise to the new branch of therapy--field therapy. The Great Patriotic War was the most important stage in the development of Russian field therapy, which was characterized by the setting up of the effective and scientifically ground system to deliver therapeutic care to the wounded and patients, which was based on the tenets of a uniform field medical doctrine.

  13. Role models and professional development in dentistry: an important resource: The views of early career stage dentists at one academic health science centre in England.

    Science.gov (United States)

    Mohamed Osama, O; Gallagher, J E

    2017-02-08

    The importance of role models, and their differing influence in early, mid- and late careers, has been identified in the process of professional development of medical doctors. There is a paucity of evidence within dentistry on role models and their attributes. To explore the views of early career dentists on positive and negative role models across key phases of professional development, together with role models' attributes and perceived influence. This is a phenomenological study collecting qualitative data through semi-structured interviews based on a topic guide. Dentists in junior (core training) hospital posts in one academic health science centre were all invited to participate. Interviews were recorded, transcribed verbatim and analysed using framework analysis. Twelve early career stage dentists, 10 of whom were female, reported having role models, mainly positive, in their undergraduate and early career phases. Participants defined role models' attributes in relation to three distinct domains: clinical attributes, personal qualities and teaching skills. Positive role models were described as "prioritising the patient's best interests", "delivering learner-centred teaching and training" and "exhibiting a positive personality", whilst negative role models demonstrated the converse. Early career dentists reported having largely positive dentist role models during- and post-dental school and report their impact on professional values and aspirations, learning outcomes and career choice. The findings suggest that these early career dentists in junior hospital posts have largely experienced and benefitted from positive role models, notably dentists, perceived as playing an important and creative influence promoting professionalism and shaping the career choices of early career stage dentists. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  14. A combined approach of DNA probe and RFLP for family and species identification of larval stages of commercially important aquatic species: A study on the surfclam Spisula solidissima

    Digital Repository Service at National Institute of Oceanography (India)

    Achuthankutty, C.T.

    This paper deals briefly with a technique developed for the identification of the early stages of veligers of surfclam Spisula solidissima from the larval stages of other common bivalve species using a combination of DNA probe and restriction...

  15. Ontogenetic loops in habitat use highlight the importance of littoral habitats for early life-stages of oceanic fishes in temperate waters

    Science.gov (United States)

    Polte, Patrick; Kotterba, Paul; Moll, Dorothee; von Nordheim, Lena

    2017-01-01

    General concepts of larval fish ecology in temperate oceans predominantly associate dispersal and survival to exogenous mechanisms such as passive drift along ocean currents. However, for tropical reef fish larvae and species in inland freshwater systems behavioural aspects of habitat selection are evidently important components of dispersal. This study is focused on larval Atlantic herring (Clupea harengus) distribution in a Baltic Sea retention area, free of lunar tides and directed current regimes, considered as a natural mesocosm. A Lorenz curve originally applied in socio-economics to describe demographic income distribution was adapted to a 20 year time-series of weekly larval herring distribution, revealing size-dependent spatial homogeneity. Additional quantitative sampling of distinct larval development stages across pelagic and littoral areas uncovered a loop in habitat use during larval ontogeny, revealing a key role of shallow littoral waters. With increasing rates of coastal change, our findings emphasize the importance of the littoral zone when considering reproduction of pelagic, ocean-going fish species; highlighting a need for more sensitive management of regional coastal zones. PMID:28205543

  16. Ontogenetic loops in habitat use highlight the importance of littoral habitats for early life-stages of oceanic fishes in temperate waters

    Science.gov (United States)

    Polte, Patrick; Kotterba, Paul; Moll, Dorothee; von Nordheim, Lena

    2017-02-01

    General concepts of larval fish ecology in temperate oceans predominantly associate dispersal and survival to exogenous mechanisms such as passive drift along ocean currents. However, for tropical reef fish larvae and species in inland freshwater systems behavioural aspects of habitat selection are evidently important components of dispersal. This study is focused on larval Atlantic herring (Clupea harengus) distribution in a Baltic Sea retention area, free of lunar tides and directed current regimes, considered as a natural mesocosm. A Lorenz curve originally applied in socio-economics to describe demographic income distribution was adapted to a 20 year time-series of weekly larval herring distribution, revealing size-dependent spatial homogeneity. Additional quantitative sampling of distinct larval development stages across pelagic and littoral areas uncovered a loop in habitat use during larval ontogeny, revealing a key role of shallow littoral waters. With increasing rates of coastal change, our findings emphasize the importance of the littoral zone when considering reproduction of pelagic, ocean-going fish species; highlighting a need for more sensitive management of regional coastal zones.

  17. PET-CT in presurgical lymph node staging in non-small cell lung cancer: the importance of false-negative and false-positive findings.

    Science.gov (United States)

    García de Castro, A Bustos; Domínguez, J Ferreirós; Bolton, R Delgado; Pérez, C Fernández; Martínez, B Cabeza; García-Esquinas, M García; Carreras Delgado, J L

    To assess the importance of false-negative and false-positive findings in computed tomography (CT) and (18)F-FDG positron emission tomography (PET) in mediastinal lymph node staging in patients undergoing surgery for non-small cell lung cancer (NSCLC). This retrospective study included 113 consecutive patients and 120 resected NSCLCs; 22 patients received neoadjuvant treatment. We compared the findings on preoperative (18)F-FDG PET-CT studies with the postoperative pathology findings. Lymph node size and primary tumor size were measured with CT, and lymph nodes and primary tumors were evaluated qualitatively and semiquantitatively (using standardized uptake values (SUVmax)) with PET. Metastatic lymph nodes were found in 26 (21.7%) of the 120 tumors and in 41 (7.7%) of the 528 lymph node stations analyzed. (18)F-FDG PET-CT yielded 53.8% sensitivity, 76.6% specificity, 38.9% positive predictive value, 85.7% negative predictive value, and 71.7% diagnostic accuracy. The false-negative rate was 14.2%. Multivariable analysis found that the factors associated with false-negative findings were a moderate degree of differentiation in the primary tumor (p = 0.005) and an SUVmax of the primary tumor >4 (p = 0.027). The false-positive rate was 61.1%, and the multivariable analysis found that lymph node size >1cm was associated with false-positive findings (p < 0.001). In mediastinal lymph node staging in patients with NSCLC, (18)F-FDG PET-CT improves the specificity and negative predictive value and helps clinicians to select the patients that will benefit from surgery. Given the high rate of false positives, histological confirmation of positive cases is recommendable. Copyright © 2017 SERAM. Publicado por Elsevier España, S.L.U. All rights reserved.

  18. Importance of RIFLE (Risk, Injury, Failure, Loss, and End-Stage Renal Failure) and AKIN (Acute Kidney Injury Network) in Hemodialysis Initiation and Intensive Care Unit Mortality.

    Science.gov (United States)

    Kara, Iskender; Yildirim, Fatma; Kayacan, Esra; Bilaloğlu, Burcu; Turkoglu, Melda; Aygencel, Gülbin

    2017-07-01

    Our study evaluated the differences between early and late hemodialysis (HD) initiation in the intensive care unit (ICU) according to the RIFLE (Risk, Injury, Failure, Loss, and End-stage renal failure) and AKIN (Acute Kidney Injury Network) classifications. On the assumption that early initiation of HD in critical patients according to the RIFLE and AKIN criteria decreases mortality, we retrospectively evaluated the medical records of 68 patients in our medical ICU and divided the patients into 2 groups: Those undergoing HD in no risk, risk, or injury stage according to RIFLE and in stage 0, I, or II according to AKIN were defined as early HD and those in failure stage according to RIFLE and in stage III according to AKIN were defined as late HD. The median age of the patients was 66.5 years, and 56.5% were male. HD was started in 25% and 39.7% of the patients in the early stage in the RIFLE and AKIN classification, respectively. According to RIFLE, HD was started in 61.5% of the surviving patients in the early stage; this rate was 16.4% in the deceased patients (P=0.001). HD was commenced in 69.2% of the surviving patients in AKIN stages 0, I, and II and in 32.7% of the deceased patients (P=0.026). Sepsis (61.5% vs. 94.5%; P=0.001) and mechanical ventilation (30.8% vs. 87.3%; PRIFLE decreased ICU mortality (61.5% vs. 16.4%; P=0.001). In conclusion, in critically ill patients, HD initiation in the early stages according to the RIFLE classification decreased our ICU mortality.

  19. The Mannose Receptor (CD206) is an important pattern recognition receptor (PRR) in the detection of the infective stage of the helminth Schistosoma mansoni and modulates IFNγ production.

    Science.gov (United States)

    Paveley, Ross A; Aynsley, Sarah A; Turner, Joseph D; Bourke, Claire D; Jenkins, Stephen J; Cook, Peter C; Martinez-Pomares, Luisa; Mountford, Adrian P

    2011-11-01

    In this study, infective larvae of the parasitic helminth Schistosoma mansoni were shown to contain a large number of glycosylated components specific for the Mannose Receptor (MR; CD206), which is an important pattern recognition receptor (PRR) of the innate immune system. MR ligands were particularly rich in excretory/secretory (E/S) material released during transformation of cercariae into schistosomula, a process critical for infection of the host. E/S material from carboxyfluorescein diacetate succinimidyl ester (CFDA-SE)-labelled cercariae showed enhanced binding by cells lines that over-express the MR. Conversely, uptake was significantly lower by bone marrow-derived macrophages (MΦ) from MR(-/-) mice, although they were more active as judged by enhanced pro-inflammatory cytokine production and CD40 expression. After natural percutaneous infection of MR(-/-) mice with CFDA-SE-labelled parasites, there were fewer cells in the skin and draining lymph nodes that were CFDA-SE(+) compared with wild-type mice, implying reduced uptake and presentation of larval parasite antigen. However, antigen-specific proliferation of skin draining lymph node cells was significantly enhanced and they secreted markedly elevated levels of IFNγ but decreased levels of IL-4. In conclusion, we show that the MR on mononuclear phagocytic cells, which are plentiful in the skin, plays a significant role in internalising E/S material released by the invasive stages of the parasite which in turn modulates their production of pro-inflammatory cytokines. In the absence of the MR, antigen-specific CD4(+) cells are Th1 biased, suggesting that ligation of the MR by glycosylated E/S material released by schistosome larvae modulates the production of CD4(+) cell specific IFNγ.

  20. The practical importance of permanent and semipermanent habitats for controlling aquatic stages of Anopheles gambiae sensu lato mosquitoes: operational observations from a rural town in western Kenya

    NARCIS (Netherlands)

    Fillinger, U.; Sonye, G.; Killeen, G.F.; Knols, B.G.J.; Becker, N.

    2004-01-01

    Control of aquatic-stage Anopheles is one of the oldest and most historically successful interventions to prevent malaria, but it has seen little application in Africa. Consequently, the ecology of immature afrotropical Anopheles has received insufficient attention. We therefore examined the populat

  1. Exploitation of a new staging area in the Dutch Wadden Sea by Greylag Geese Anser anser : the importance of food-plant dynamics

    NARCIS (Netherlands)

    Bakker, L; van der Wal, R; Esselink, Peter; Siepel, A

    1999-01-01

    The colonisation by Greylag Geese Anser anser of a new autumn migration staging area was studied on the island of Schiermonnikoog, The Netherlands. Over 500 Greylag Geese first visited the island in 1991. During subsequent years, peak numbers rose to 700-900 birds. The geese most likely originated f

  2. The Importance of California Public Libraries in Increasing Public Access to the Internet: Findings from the InFoPeople Site Visits. Stage II Final Report.

    Science.gov (United States)

    Bertot, John Carlo; McClure, Charles R.; Ryan, Joe

    In less than five years, the California State Library-sponsored InFoPeople project connected 46% of California's public libraries to the Internet and established a highly regarded, sustained training program to assist librarians in taking advantage of the new networked resources and services. The primary objective of this Stage II report was to…

  3. Staging Mobilities

    DEFF Research Database (Denmark)

    Jensen, Ole B.

    that mobility is more than movement between point A and B. It explores how the movement of people, goods, information, and signs influences human understandings of self, other and the built environment. Moving towards a new understanding of the relationship between movement, interaction and environments......In recent years, the social sciences have taken a “mobilities turn.” There has been a developing realisation that mobilities do not “just happen.” Mobilities are carefully and meticulously designed, planned and staged (from above). However, they are equally importantly acted out, performed...... and lived as people are “staging themselves” (from below). Staging mobilities is a dynamic process between “being staged” (for example, being stopped at traffic lights) and the “mobile staging” of interacting individuals (negotiating a passage on the pavement). Staging Mobilities is about the fact...

  4. Risk factors for relapse of middle-stage squamous cell carcinoma of the submandibular region and floor of mouth: the importance of en bloc resection.

    Science.gov (United States)

    Feng, Zhien; Xu, Qiao Shi; Qin, Li Zheng; Li, Hua; Li, Jin Zhong; Su, Ming; Han, Zhengxue

    2016-01-01

    Our aim was to investigate retrospectively the rate of recurrence in the intervening region for middle-stage squamous cell carcinoma (SCC) of the tongue and identify the factors that predict relapse and prognosis. A total of 204 patients were included, 96 in the en bloc group and 108 in the control group. The groups were comparable. Two patients in the en bloc group (2%) and 12 in the control group (11%) developed recurrences in the intervening region. Kaplan-Meier analysis showed a reduction in the 5-year disease-specific survival once a recurrence had developed after the primary operation (77% compared with 14%, pen bloc group developed significantly fewer recurrences (2%) than the control group (11%) during the five years; p=0.037), and also had better 5-year disease-specific survival (80% compared with 66%, p=0.04). Cox's multivariate regression indicated that the pathological nodal status (p=0.016) and surgical technique (p=0.037) were independent predictive factors for the 5-year recurrence rate, as well as of 5-year disease-specific survival (p=0.001 and p=0.050, respectively). Recurrence in the intervening region is a negative prognostic factor for these patients, and we recommend en bloc resection as the management of choice for middle-stage SCC of the tongue.

  5. The highly conserved aspartic acid residue between hypervariable regions 1 and 2 of human immunodeficiency virus type 1 gp120 is important for early stages of virus replication.

    Science.gov (United States)

    Wang, W K; Essex, M; Lee, T H

    1995-01-01

    Between hypervariable regions V1 and V2 of human immunodeficiency virus type 1 (HIV-1) gp120 lies a cluster of relatively conserved residues. The contribution of nine charged residues in this region to virus infectivity was evaluated by single-amino-acid substitutions in an infectious provirus clone. Three of the HIV-1 mutants studied had slower growth kinetics than the wild-type virus. The delay was most pronounced in a mutant with an alanine substituted for an aspartic acid residue at position 180. This aspartic acid is conserved by all HIV-1 isolates with known nucleotide sequences. Substitutions with three other residues at this position, including a negatively charged glutamic acid, all affected virus infectivity. The defect identified in these mutants suggests that this aspartic acid residue is involved in the early stages of HIV-1 replication. PMID:7983752

  6. Importance of Local Control in Early-Stage Prostate Cancer: Outcomes of Patients With Positive Post-Radiation Therapy Biopsy Results Treated in RTOG 9408

    Energy Technology Data Exchange (ETDEWEB)

    Krauss, Daniel J., E-mail: dkrauss@beaumont.edu [Department of Radiation Oncology, Oakland University William Beaumont School of Medicine, Royal Oak, Michigan (United States); Hu, Chen [NRG Statistics and Data Management Center, Philadelphia, Pennsylvania (United States); Bahary, Jean-Paul [Centre Hospitalier de l' Université de Montréal-Notre Dame, Montreal, Quebec (Canada); Souhami, Luis [McGill University, Montreal, Quebec (Canada); Gore, Elizabeth M. [Medical College of Wisconsin, Milwaukee, Wisconsin (United States); Chafe, Susan Maria Jacinta [Cross Cancer Institute, Edmonton, Alberta (Canada); Leibenhaut, Mark H. [Sutter General Hospital, Sacramento, California (United States); Narayan, Samir [Michigan Cancer Research Consortium CCOP (United States); Torres-Roca, Javier [H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida (United States); Michalski, Jeff [Washington University, St. Louis, Missouri (United States); Zeitzer, Kenneth L. [Albert Einstein Medical Center, Bronx, New York, New York (United States); Donavanik, Viroon [Christiana Care Health Services Inc CCOP, Newark, Delaware (United States); Sandler, Howard [Cedars-Sinai Medical Center, Los Angeles, California (United States); McGowan, David G. [Cross Cancer Institute, Edmonton, Alberta (Canada); Jones, Christopher U. [Sutter General Hospital, Sacramento, California (United States); Shipley, William U. [Dana-Farber Cancer Institute, Boston, Massachusetts (United States)

    2015-07-15

    Purpose: The purpose of this study was to assess the association between positive post-radiation therapy (RT) biopsy results and subsequent clinical outcomes in males with localized prostate cancer. Methods and Materials: Radiation Therapy Oncology Group study 94-08 analyzed 1979 males with prostate cancer, stage T1b-T2b and prostate-specific antigen concentrations of ≤20 ng/dL, to investigate whether 4 months of total androgen suppression (TAS) added to RT improved survival compared to RT alone. Patients randomized to receive TAS received flutamide with luteinizing hormone releasing hormone (LHRH) agonist. According to protocol, patients without evidence of clinical recurrence or initiation of additional endocrine therapy underwent repeat prostate biopsy 2 years after RT completion. Statistical analysis was performed to evaluate the impact of positive post-RT biopsy results on clinical outcomes. Results: A total of 831 patients underwent post-RT biopsy, 398 were treated with RT alone and 433 with RT plus TAS. Patients with positive post-RT biopsy results had higher rates of biochemical failure (hazard ratio [HR] = 1.7; 95% confidence interval [CI] = 1.3-2.1) and distant metastasis (HR = 2.4; 95% CI = 1.3-4.4) and inferior disease-specific survival (HR = 3.8; 95% CI = 1.9-7.5). Positive biopsy results remained predictive of such outcomes after correction for potential confounders such as Gleason score, tumor stage, and TAS administration. Prior TAS therapy did not prevent elevated risk of adverse outcome in the setting of post-RT positive biopsy results. Patients with Gleason score ≥7 with a positive biopsy result additionally had inferior overall survival compared to those with a negative biopsy result (HR = 1.56; 95% CI = 1.04-2.35). Conclusions: Positive post-RT biopsy is associated with increased rates of distant metastases and inferior disease-specific survival in patients treated with definitive RT and was associated with inferior overall

  7. Importance of metabolic changes induced by chemotherapy on prognosis of early-stage breast cancer patients: a review of potential mechanisms.

    Science.gov (United States)

    Gadéa, E; Thivat, E; Planchat, E; Morio, B; Durando, X

    2012-04-01

    Weight variation has been reported as a side effect of chemotherapy treatment in early breast cancer patients and has been identified as a factor of poor prognosis. Causes of weight variation during chemotherapy and mechanisms involved in the poor prognosis have been little studied. Here is reviewed the current knowledge about the main causes and mechanisms involved in body weight change. Special emphasis is placed on factors associated with weight variation which could potentially be involved in the risk of relapse in breast cancer survivors. In recent decades, some studies have investigated the causes of weight variation by studying energy balance of breast cancer patients during chemotherapy. Weight gain or loss may be the consequence of energy imbalance through different factors linked with chemotherapy, such as poor treatment tolerance, decreased muscle mass and function, or hormonal alterations. This results in body composition modifications in favour of fat gain and/or lean body mass loss. Increased adipose tissue, especially in the abdominal region, could induce metabolic disturbances such as insulin resistance, through various pathways involving adipokines. These molecules have growth properties and could therefore play a role in cancer relapse. Understanding such mechanisms is key to developing preventive strategies for improving the prognosis of early-stage breast cancer patients.

  8. Factors important for efficacy of stereotactic body radiotherapy of medically inoperable stage I lung cancer. A retrospective analysis of patients treated in the Nordic countries

    DEFF Research Database (Denmark)

    Baumann, Pia; Nyman, Jan; Lax, Ingmar

    2006-01-01

    We reviewed results of SBRT treatment of 138 patients with medically inoperable stage I NSCLC treated during 1996-2003 at five different centres in Sweden and Denmark. Mean age was 74 years (range 56-90) with 69 men and 72 women. SBRT was delivered using a 3D conformal multifield technique...... and a stereotactic body frame. Doses delivered were 30-48 Gy (65% isodose at the periphery of planning target volume, PTV) in 2-4 fractions. Equivalent dose in 2 Gy fractions (EQD2) was in the range of 50-100 Gy. Mean gross tumour volume (GTV) was 39 cm3 (2-436), and planning target volume was 101 cm3 (11......-719). Overall response rate (CR, PR) was 61% (84/138). SD was noted in 36% (50/138). During a median follow-up period of 33 months (1-107), 16 (12%) local failures occurred, ten of which also included distant metastases. Local failure was associated with tumour size, target definition and central or pleura...

  9. Factors important for efficacy of stereotactic body radiotherapy of medically inoperable stage I lung cancer. A retrospective analysis of patients treated in the Nordic countries

    DEFF Research Database (Denmark)

    Baumann, Pia; Nyman, Jan; Lax, Ingmar;

    2006-01-01

    We reviewed results of SBRT treatment of 138 patients with medically inoperable stage I NSCLC treated during 1996-2003 at five different centres in Sweden and Denmark. Mean age was 74 years (range 56-90) with 69 men and 72 women. SBRT was delivered using a 3D conformal multifield technique...... and a stereotactic body frame. Doses delivered were 30-48 Gy (65% isodose at the periphery of planning target volume, PTV) in 2-4 fractions. Equivalent dose in 2 Gy fractions (EQD2) was in the range of 50-100 Gy. Mean gross tumour volume (GTV) was 39 cm3 (2-436), and planning target volume was 101 cm3 (11...... proximity. Distant metastases occurred in 25% (35/138) of the patients. Ninety-one (65%) patients died during follow-up of which 55 patients (60%) died of other causes than lung cancer. Three- and 5-year overall survival was 52 and 26% respectively. Lung cancer specific 3- and 5-year overall survival was 66...

  10. The importance of release of proinflammatory cytokines, ROS, and NO in different stages of colon carcinoma growth and metastasis after treatment with cytotoxic drugs.

    Science.gov (United States)

    Paduch, Roman; Kandefer-Szerszeń, Martyna; Piersiak, Tomasz

    2010-01-01

    In colorectal cancers, the local cytokine network and the levels of nitric oxide (NO) and reactive oxygen species (ROS) are known to be closely related to cancer progression and metastasis, but the influence of the currently administered therapies on the cancer microenvironment is not completely understood. We analyzed the levels of reactive oxygen species (ROS), nitric oxide (NO), and cachexia-mediated cytokines (IL-1beta, IL-6, TNF-alpha) in cocultures of human colon carcinoma spheroids prepared with cells derived from tumors of different grades with human normal colon epithelial and myofibroblast cells and normal endothelial cells. We also analyzed the influence of standard chemotherapy with 5-fluorouracil (5-FU) and leucovorin (LV) combined with camptothecin (CPT-11) (IFL regimen with drug concentrations adjusted to in vitro conditions) on these parameters. The results indicated that adhesion of colon carcinoma spheroids to colon epithelium and myofibroblast monolayers induced O2- anion production but decreased NO levels compared to the sum of the radicals released by monocultures of the two types of cells. Coculture of colon carcinoma spheroids with endothelium was an exception to this rule, as only HT29 cells decreased NO production. In cocultures, anticancer drugs additionally, though only slightly and insignificantly, increased the production of the radicals compared to a nontreated coculture, but in monocultures, the drugs, and especially CPT-11, were ROS inducers and simultaneously NO production inhibitors. However, the levels of released ROS and NO were dependent on the stage of colon carcinoma that the cells were derived from. LS180 cells (grade B) grown in monocultures produced the lowest ROS levels but were the best producers of NO. Adhesion of tumor spheroids to normal cells influenced the microenvironmental cytokine network compared to monocultures, decreasing IL-1beta and TNF-alpha secretion but significantly enhancing L-6 levels. The addition of

  11. Importance of glomerular filtration rate change as surrogate endpoint for the future incidence of end-stage renal disease in general Japanese population: community-based cohort study.

    Science.gov (United States)

    Kanda, Eiichiro; Usui, Tomoko; Kashihara, Naoki; Iseki, Chiho; Iseki, Kunitoshi; Nangaku, Masaomi

    2017-09-07

    Because of the necessity for extended period and large costs until the event occurs, surrogate endpoints are indispensable for implementation of clinical studies to improve chronic kidney disease (CKD) patients' prognosis. Subjects with serum creatinine level for a baseline period over 1-3 years were enrolled (n = 69,238) in this community-based prospective cohort study in Okinawa, Japan, and followed up for 15 years. The endpoint was end-stage renal disease (ESRD). The percent of estimated glomerular filtration rate (%eGFR) change was calculated on the basis of the baseline period. Subjects had a mean ± SD age, 55.59 ± 14.69 years; eGFR, 80.15 ± 21.15 ml/min/1.73 m(2). Among the subjects recruited, 15.81% had a low eGFR (changes over 2 or 3 years in the high- and low-eGFR groups. The specificities and positive predictive values for ESRD based on a cutoff value of %eGFR change of less than -30% over 2 or 3 years were high in the high- and low-eGFR groups. %eGFR change tends to be associated with the risk of ESRD. %eGFR change of less than -30% over 2 or 3 years can be a candidate surrogate endpoint for ESRD in the general Japanese population.

  12. An application of a five-stage consumer behaviour decision making model: An exploratory study of Chinese purchasing of imported health food

    OpenAIRE

    Lee, Sean Henry

    2005-01-01

    China has the single largest potential consumer market in the world. However, the study of Chinese consumer behaviour in purchasing health food in general is relatively rare. The research on Chinese consumer decision-making process on purchasing imported health food products in particular, is even less common. This present exploratory study reviews the previous research on culture and consumer decision-making process, as well as influence of cultural factors on Chinese consumer decisionmaking...

  13. Importance of Understanding Stage in Translation from the Perspective of Habermas Universal Pragmatics%从哈贝马斯普遍语用学理论看翻译理解阶段的重要性

    Institute of Scientific and Technical Information of China (English)

    刘红梅

    2012-01-01

    Based on the previous studies, this article illustrates the importance of the understanding stage of transla tion from the perspectives of Habermas Universal Pragmatics. It argues that applying Habermas Universal Pragmat ics to the study on the importanc0 d the understanding stage in translation process enables translators understand the importance of the understanding stage from the theoretical angels and solve some problems in the understanding stage of translation activities. This strategy, to some degree, is also instructive to the study on text translation process of different styles.%在前人研究成果的基础上,以哈贝马斯普遍语用学为视角,就翻译理解阶段的重要性进行了探讨。把哈贝马斯普遍语用学引入翻译理解阶段的重要性的研究,有助于译者从理论的高度明白翻译过程中理解阶段的重要性,解决翻译理解时遇到的问题。这一研究策略对于各种文体文本翻译过程的研究也具有一定的指导意义。

  14. Developmental stage is an important factor that determines the antioxidant responses of young and old grapevine leaves under UV irradiation in a green-house.

    Science.gov (United States)

    Majer, Petra; Hideg, Eva

    2012-01-01

    The impact of UV irradiation was studied on photosynthesis, photosystem II photochemical yields and antioxidant responses using green-house grown grapevine (Vitis vinifera L. cv. Chardonnay) leaves. Supplemental UV irradiation (280-400 nm) was centred in the UV-B region, and corresponded to 8.95 kJ m⁻² d⁻¹ global (280-400 nm) or 8.04 kJ m⁻² d⁻¹ UV-B (280-315 nm) biologically effective dose. UV irradiation was applied daily and its effects were evaluated after 4-days. Younger (1-3 weeks-old) leaves (YL) and older (4-6 weeks-old) leaves (OL) were affected differently, UV irradiation decreased their photochemical yields to 78% and 56%, respectively. Unlike OL, YL responded by an increase in UV-B absorbing pigment, anthocyanin and total phenolics contents. UV irradiation increased total antioxidant capacities in YL but not in OL. YL were also different in their ability to increase specific hydroxyl radical and singlet oxygen neutralizing capacities in response to the supplemental UV irradiation, which is reported here for the first time. Our results suggest that the ability of maintaining photosynthesis under supplemental UV is not necessarily determined by base levels of antioxidants but rather by their inducibilities in response to the irradiation and emphasise the importance of comparing leaves of the same age in UV studies. Correlations between various antioxidant capacities, pigment contents and photosynthesis parameters were also examined. However, no single element of the defence system can be picked up as decisive factor of sensitivity to UV.

  15. Staging Mobilities

    DEFF Research Database (Denmark)

    Jensen, Ole B.

    In recent years, the social sciences have taken a “mobilities turn.” There has been a developing realisation that mobilities do not “just happen.” Mobilities are carefully and meticulously designed, planned and staged (from above). However, they are equally importantly acted out, performed...... that mobility is more than movement between point A and B. It explores how the movement of people, goods, information, and signs influences human understandings of self, other and the built environment. Moving towards a new understanding of the relationship between movement, interaction and environments......, the book asks: what are the physical, social, technical, and cultural conditions to the staging of contemporary urban mobilities?...

  16. Cancer Staging

    Science.gov (United States)

    ... the tumor is to grow and spread The TNM Staging System The TNM system is the most widely used cancer staging system. Most hospitals and medical centers use the TNM system as their main method for cancer reporting. ...

  17. Well staged

    Energy Technology Data Exchange (ETDEWEB)

    Budd, Godfrey

    2011-06-15

    Packers Plus Energy Services Inc. has commercially launched QuickFRAC, a multi-stage completition system which can fracture four to five isolated stages in one treatment and set up a record of 23-stage slickwater frac in less than 10 hours. It could take up to 40 days to do 100 fracture treatments with other systems. This technology makes it possible to distribute fluid at each port thanks to the limited entry system. In order to make multiple isolated stages within one treatment zone, each zone includes multiple QuickPORT sleeves with packers on either side. The other technology which made this possible is the repeater port system, it allows them to perform more frac stages. This technology could be useful in the future since the need for stages will be doubling soon with microdarcy shale oil extraction which is more difficult than gas.

  18. Trading stages

    DEFF Research Database (Denmark)

    Steiner, Uli; Tuljapurkar, Shripad; Coulson, Tim

    2012-01-01

    Interest in stage-and age structured models has recently increased because they can describe quantitative traits such as size that are left out of age-only demography. Available methods for the analysis of effects of vital rates on lifespan in stage-structured models have not been widely applied ...... examples. Much of our approach relies on trading of time and mortality risk in one stage for time and risk in others. Our approach contributes to the new framework of the study of age- and stage-structured biodemography....

  19. Staging Mobilities / Designing Mobilities

    DEFF Research Database (Denmark)

    Jensen, Ole B.

    2015-01-01

    In recent years, urban research has taken a ‘mobilities turn’. There has been a developing realisation that mobilities do not ‘just happen.’ Mobilities are carefully and meticulously designed, planned and staged (from above). However, they are equally importantly acted out, performed and lived...... as people are ‘staging themselves’ (from below). Staging mobilities is a dynamic process between ‘being staged’ (for example, being stopped at traffic lights) and the ‘mobile staging’ of interacting individuals (negotiating a passage on the pavement). Staging mobilities is about the fact that mobility...... asks: what are the physical, social, technical, and cultural conditions to the staging of contemporary urban mobilities? The theoretical framing in the Staging mobilities book is applied to four in-depth cases in the accompanying volume Designing mobilities.This book explore how places, sites...

  20. Staging atmospheres

    DEFF Research Database (Denmark)

    Bille, Mikkel; Bjerregaard, Peter; Sørensen, Tim Flohr

    2015-01-01

    The article introduces the special issue on staging atmospheres by surveying the philosophical, political and anthropological literature on atmosphere, and explores the relationship between atmosphere, material culture, subjectivity and affect. Atmosphere seems to occupy one of the classic...... localities of tensions between matter and the immaterial, the practical and the ideal, and subject and object. In the colloquial language there can, moreover, often seem to be something authentic or genuine about atmosphere, juxtaposing it to staging, which is implied to be something simulated or artificial....... This introduction seeks to outline how a number of scholars have addressed the relationship between staged atmospheres and experience, and thus highlight both the philosophical, social and political aspects of atmospheres...

  1. Normalization: A Preprocessing Stage

    OpenAIRE

    Patro, S. Gopal Krishna; Sahu, Kishore Kumar

    2015-01-01

    As we know that the normalization is a pre-processing stage of any type problem statement. Especially normalization takes important role in the field of soft computing, cloud computing etc. for manipulation of data like scale down or scale up the range of data before it becomes used for further stage. There are so many normalization techniques are there namely Min-Max normalization, Z-score normalization and Decimal scaling normalization. So by referring these normalization techniques we are ...

  2. Acciones finales discriminantes de voleibol en categorías de formación masculina: importancia del saque en los partidos igualados. (Discriminatory volleyball final actions in male formative stages: importance .

    Directory of Open Access Journals (Sweden)

    Carlos Dávila-Romero

    2012-04-01

    Full Text Available Resumen El objetivo principal del presente estudio fue constatar la importancia del saque en categorías de formación en voleibol masculina y determinar qué otras acciones son relevantes para la victoria en el quinto set de los partidos igualados. Se recogieron un total de 218 partidos (102 en categoría infantil y 116 en categoría cadete, 755 sets (354 en categoría infantil y 401 en categoría cadete y 744 jugadores (360 en categoría infantil y 384 en categoría cadete de los Campeonatos de España de Voleibol de Valladolid 2008 y Huelva 2009 (España en edad escolar masculino (12-16 años. Finalmente se analizaron sólo el quinto set de los partidos igualados. Los resultados del análisis discriminante, mostraron como el saque positivo en ambas categorías, el error en categoría infantil y el ataque positivo en categoría cadete predicen la victoria y/o derrota en el quinto set. Estos sugieren que en momentos decisivos de set y en ambas categorías, el acierto en las acciones ofensivas y el control del patrón técnico del saque es fundamental en estos partidos igualados.AbstractThe aim of this study was to confirm the importance of the serve on formatives stages male volleyball and determine what actions are relevant to the victory in the fifth set on equal matches. We collected a total of 218 matches (102 and 116 in infantile and cadet categories, 755 sets (354 and 401 in infantile and cadet categories and 744 players (360 and 384 in infantile and cadet categories of the Spain Volleyball Championships held in Huelva and Valladolid in 2008 and 2009 (Spain at school-age (12-16 years. Finally were analyzed only the fifth set of equal matches. The results of the discriminant analysis showed how the positive serve in both categories, the error in infantile category and in cadet positive attack may predict victory and / or defeat in the fifth set. They suggest that, in both categories, the success in offensive actions and control of the

  3. Thyroid Cancer Staging

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Ja Young; Kim, Soo Jin; Kim, Eun Kyung; Kwak, Jin Young [Yonsei University College of Medicine, Seoul (Korea, Republic of)

    2011-06-15

    The current prevalence of thyroid cancer in women is high. Likewise, other cancers and thyroid cancer have been based on the TNM classification system. Staging of thyroid cancer has an important role in determining the extent of surgical excision and lymph node dissection, planning the adjuvant therapy after surgery and predicting the recurrence rate and the prognosis of patients. Ultrasonography is the basic imaging modality to identify the tumor size and the extent of lymph node metastasis. More recently, computed tomography, magnetic resonance imaging and positron emission tomography provide additional help for the staging of thyroid cancer. So, this article describes the 7th edition of the TNM staging of thyroid cancer, as proposed by the American Joint Committee on Cancer, and the details of radiologic evaluation of the T, N and M stages

  4. Staging Collaborative Innovation Processes

    DEFF Research Database (Denmark)

    Pedersen, Signe; Clausen, Christian

    Organisations are currently challenged by demands for increased collaborative innovation internally as well as with external and new entities - e.g. across the value chain. The authors seek to develop new approaches to managing collaborative innovative processes in the context of open innovation...... and public private innovation partnerships. Based on a case study of a collaborative design process in a large electronics company the paper points to the key importance of staging and navigation of collaborative innovation process. Staging and navigation is presented as a combined activity: 1) to translate...

  5. Composers on stage

    DEFF Research Database (Denmark)

    Groth, Sanne Krogh

    A trend on the scene of contemporary music is composers going on stage, performing their pieces themselves. Within a discourse of popular music, this is more the rule than exception, but when it comes to the context of contemporary scored music, the historical and aesthetic context differs......, and something quite different is undergoing. This paper intends to discuss three examples of performances in which the composer’s appearance on stage was an important part of the piece, - both when it came to the role as a performer and as an individual person – as representer and presenter. The paper intends...... 2011 and Fischer-Lichte 2008) Hereby, the role of the composer appearing on stage is discussed from an aesthetic point of view; meanwhile social and political aspects of the phenomenon are also addressed. The three artistic works discussed are Simon Steen-Andersen’s Run Time Error (2009-), Niels...

  6. IMPORTANT NOTIFICATION

    CERN Multimedia

    HR Department

    2009-01-01

    Green plates, removals and importation of personal effects Please note that, as from 1 April 2009, formalities relating to K and CD special series French vehicle plates (green plates), removals and importation of personal effects into France and Switzerland will be dealt with by GS Department (Building 73/3-014, tel. 73683/74407). Importation and purchase of tax-free vehicles in Switzerland, as well as diplomatic privileges, will continue to be dealt with by the Installation Service of HR Department (Building 33/1-011, tel. 73962). HR and GS Departments

  7. Stages of Gastric Cancer

    Science.gov (United States)

    ... liver cancer . The following stages are used for gastric cancer: Stage 0 (Carcinoma in Situ) In stage 0 , abnormal cells are ... check-ups. Treatment Options by Stage Stage 0 (Carcinoma in ... Stage I Gastric Cancer Treatment of stage I gastric cancer may ...

  8. Staging of prostate cancer.

    Science.gov (United States)

    Cheng, Liang; Montironi, Rodolfo; Bostwick, David G; Lopez-Beltran, Antonio; Berney, Daniel M

    2012-01-01

    Prostatic carcinoma (PCa) is a significant cause of cancer morbidity and mortality worldwide. Accurate staging is critical for prognosis assessment and treatment planning for PCa. Despite the large volume of clinical activity and research, the challenge to define the most appropriate and clinically relevant staging system remains. The pathologically complex and uncertain clinical course of prostate cancer further complicates the design of staging classification and a substaging system suitable for individualized care. This review will focus on recent progress and controversial issues related to prostate cancer staging. The 2010 revision of the American Joint Committee on Cancer/Union Internationale Contre le Cancer (AJCC/UICC) tumour, node and metastasis (TNM) system is the most widely used staging system at this time. Despite general acceptance of the system as a whole, there is controversy and uncertainty about its application, particularly for T2 subclassification. The three-tiered T2 classification system for organ-confined prostate cancer is superfluous, considering the biology and anatomy of PCa. A tumour size-based substaging system may be considered in the future TNM subclassification of pT2 cancer. Lymph node status is one of the most important prognostic factors for prostate cancer. Nevertheless, clinical outcomes in patients with positive lymph nodes are variable. Identification of patients at the greatest risk of systemic progression helps in the selection of appropriate therapy. The data suggest that the inherent aggressiveness of metastatic prostate cancer is closely linked to the tumour volume of lymph node metastasis. We recommend that a future TNM staging system should consider subclassification of node-positive cancer on the basis of nodal cancer volume, using the diameter of the largest nodal metastasis and/or the number of positive nodes.

  9. [Imported histoplasmosis].

    Science.gov (United States)

    Stete, Katarina; Kern, Winfried V; Rieg, Siegbert; Serr, Annerose; Maurer, Christian; Tintelnot, Kathrin; Wagner, Dirk

    2015-06-01

    Infections with Histoplasma capsulatum are rare in Germany, and mostly imported from endemic areas. Infections can present as localized or disseminated diseases in immunocompromised as well as immunocompetent hosts. A travel history may be a major clue for diagnosing histoplasmosis. Diagnostic tools include histology, cultural and molecular detection as well as serology. Here we present four cases of patients diagnosed and treated in Freiburg between 2004 and 2013 that demonstrate the broad range of clinical manifestations of histoplasmosis: an immunocompetent patient with chronic basal meningitis; a patient with HIV infection and fatal disseminated disease; a patient with pulmonary and cutaneous disease and mediastinal and cervical lymphadenopathy; and an immunosuppressed patient with disseminated involvement of lung, bone marrow and adrenal glands.

  10. The Importance of Developing Learners' Implicit Knowledge in the Early Stage of Their Language Learning%探索隐性知识在语言学习早期的重要性

    Institute of Scientific and Technical Information of China (English)

    王志云; 王松

    2011-01-01

    作为一门学科,语言长期给人一种迷茫。不进学校,人们自然会讲母语;进了学校,人们也不一定会讲外语。其实,该问题的关键是人们没有搞清楚语言的二重性或二种知识:显性知识(有关语言的知识)和隐性知识(语言自身)。围绕这一现象,本文从理论和实践上对这两种知识在语言学习过程中的影响和作用作了一定的阐述与论证。指出要让学生掌握语言,教师必须充分认识语言的基本特征和语言隐性知识的重要性,用隐形学习的方式来开拓学生的隐性语法和隐形记忆的能力,以正真掌握语言。%Being a subject in school,language has puzzled people for a long time.Without entering a school,they can speak their mother tongue very well;however,studying at school,students are not definitely able to speak a foreign language that they learn.In fact,the key problem is that many teachers are not clear of the dual nature of the language or two different kinds of knowledge that a language has-explicit knowledge(the knowledge about a language) and implicit knowledge(the ability knowing a language).With a focus on this phenomenon,the present article describes and testifies the different role of the two kinds of knowledge in the process of language learning both in theory and in practice.It points out that to guide students to acquire a language,teachers should first of all understand the importance of the basic features of a language and implicit knowledge and help students develop their implicit grammar and implicit memory by means of implicit learning,so that they can acquire the language in the end.

  11. Staging of unipolar affective illness

    Directory of Open Access Journals (Sweden)

    Ewa Ferensztajn

    2014-12-01

    Full Text Available In this article, a concept of staging of unipolar affective illness (recurrent depression is presented. In respective subchapters, three most important aspects of this issue have been discussed: 1 staging of unipolar affective illness; 2 staging of treatment-resistant depression; and 3 conversion of unipolar into bipolar affective illness. The evidence for so called neuroprogression of the illness, accumulated in recent years, has allowed for a classification of staging based on a concept of allostasis and allostatic load. In the course of illness, changes in neuroendocrine system (mainly hypothalamic pituitary-adrenal (HPA axis, immunological system, mechanisms of oxidative stress, neurotransmitters, neurotrophic factors as well as structural and functional changes of the brain occur. In their paper of 2007, Fava and Tossani elaborated a concept of staging of unipolar affective illness presenting a continuum model of five consecutive stages with specific clinical features. In the present paper, a concept of treatment-resistant depression and staging of treatment resistance is presented in the context of several models. An important determinant of treatment-resistant depression is so called subthreshold bipolarity which is connected with worse efficacy of antidepressant drugs. In the course of illness, there is a possibility of changing diagnosis from recurrent depression into bipolar affective illness. The studies on this issue show that frequency of such diagnostic conversion is 1,5% of depressed patients per year.

  12. Calibration of Nanopositioning Stages

    Directory of Open Access Journals (Sweden)

    Ning Tan

    2015-12-01

    Full Text Available Accuracy is one of the most important criteria for the performance evaluation of micro- and nanorobots or systems. Nanopositioning stages are used to achieve the high positioning resolution and accuracy for a wide and growing scope of applications. However, their positioning accuracy and repeatability are not well known and difficult to guarantee, which induces many drawbacks for many applications. For example, in the mechanical characterisation of biological samples, it is difficult to perform several cycles in a repeatable way so as not to induce negative influences on the study. It also prevents one from controlling accurately a tool with respect to a sample without adding additional sensors for closed loop control. This paper aims at quantifying the positioning repeatability and accuracy based on the ISO 9283:1998 standard, and analyzing factors influencing positioning accuracy onto a case study of 1-DoF (Degree-of-Freedom nanopositioning stage. The influence of thermal drift is notably quantified. Performances improvement of the nanopositioning stage are then investigated through robot calibration (i.e., open-loop approach. Two models (static and adaptive models are proposed to compensate for both geometric errors and thermal drift. Validation experiments are conducted over a long period (several days showing that the accuracy of the stage is improved from typical micrometer range to 400 nm using the static model and even down to 100 nm using the adaptive model. In addition, we extend the 1-DoF calibration to multi-DoF with a case study of a 2-DoF nanopositioning robot. Results demonstrate that the model efficiently improved the 2D accuracy from 1400 nm to 200 nm.

  13. Understanding cancer staging

    Science.gov (United States)

    ... provide more detailed information about the cancer stage. TNM Staging System The most common system for staging ... in the form of solid tumor is the TNM system. Most providers and cancer centers use it ...

  14. Cervical Cancer Stage IVA

    Science.gov (United States)

    ... historical Searches are case-insensitive Cervical Cancer Stage IVA Add to My Pictures View /Download : Small: 756x576 ... Large: 3150x2400 View Download Title: Cervical Cancer Stage IVA Description: Stage IVA cervical cancer; drawing and inset ...

  15. Between Stage and Screen

    NARCIS (Netherlands)

    Tornqvist, Egil

    1996-01-01

    Ingmar Bergman is worldwide known as a film and stage director. Yet no-one has attempted to compare his stage and screen activities. In Between stage and screen Egil Tornqvist examines formal and thematical correspondences and differences between a number of Bergman's stage, screen, and radio produc

  16. Bipolar disorder: staging and neuroprogression

    Directory of Open Access Journals (Sweden)

    Rodrigues, Aline André

    2014-04-01

    Full Text Available In bipolar disorder illness progression has been associated with a higher number of mood episodes and hospitalizations, poorer response to treatment, and more severe cognitive and functional impairment. This supports the notion of the use of staging models in this illness. The value of staging models has long been recognized in many medical and malignant conditions. Staging models rely on the fact that different interventions may suit different stages of the disorder, and that better outcomes can be obtained if interventions are implemented earlier in the course of illness. Thus, treatment planning would benefit from the assessment of cognition, functioning and comorbidities. Staging may offer a means to refine treatment options, and most importantly, to establish a more precise diagnosis. Moreover, staging could have utility as course specifier and may guide treatment planning and better information to patients and their family members of what could be expected in terms of prognosis. The present study reviews the clinical and biological basis of the concept of illness progression in bipolar disorder.

  17. Stages of Esophageal Cancer

    Science.gov (United States)

    ... stage 0 , abnormal cells are found in the mucosa or submucosa layer of the esophagus wall. These ... found. Stage IA : Cancer has formed in the mucosa or submucosa layer of the esophagus wall. The ...

  18. Stages of Adolescence

    Science.gov (United States)

    ... Español Text Size Email Print Share Stages of Adolescence Page Content Article Body Adolescence, these years from puberty to adulthood, may be roughly divided into three stages: early adolescence, generally ages eleven to fourteen; middle adolescence, ages ...

  19. Cervical Cancer Stage IVB

    Science.gov (United States)

    ... of the body, such as the lymph nodes, lung, liver, intestine, or bone. Stage IVB cervical cancer. Topics/Categories: Anatomy -- Gynecologic Cancer Types -- Cervical Cancer Staging Type: Color, ...

  20. Dynamic Stage Design

    Institute of Scientific and Technical Information of China (English)

    Florian von Hofen[GER

    2013-01-01

    Concepts and methods for dynamic stage designs were introduced ranging from different ifelds of TV live shows, exhibitions and theatre performances, and a special emphasis was put on solution to the theatre stage design.

  1. Ages and Stages: Teen

    Science.gov (United States)

    ... Spread the Word Shop AAP Find a Pediatrician Ages & Stages Prenatal Baby Toddler Preschool Gradeschool Teen Dating & ... Safety School Substance Abuse Young Adult Healthy Children > Ages & Stages > Teen Teen Article Body Adolescence can be ...

  2. Breast cancer staging

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/patientinstructions/000911.htm Breast cancer staging To use the sharing features on this ... Once your health care team knows you have breast cancer , they will do more tests to stage it. ...

  3. Cervical Cancer Stage IIIB

    Science.gov (United States)

    ... hyphen, e.g. -historical Searches are case-insensitive Cervical Cancer Stage IIIB Add to My Pictures View /Download : ... 1425x1326 View Download Large: 2850x2651 View Download Title: Cervical Cancer Stage IIIB Description: Stage IIIB cervical cancer; drawing ...

  4. Cervical Cancer Stage IB

    Science.gov (United States)

    ... hyphen, e.g. -historical Searches are case-insensitive Cervical Cancer Stage IB Add to My Pictures View /Download : ... 1613x1200 View Download Large: 3225x2400 View Download Title: Cervical Cancer Stage IB Description: Stage IB1 and IB2 cervical ...

  5. Cervical Cancer Stage IIIA

    Science.gov (United States)

    ... hyphen, e.g. -historical Searches are case-insensitive Cervical Cancer Stage IIIA Add to My Pictures View /Download : ... 1275x1275 View Download Large: 2550x2550 View Download Title: Cervical Cancer Stage IIIA Description: Stage IIIA cervical cancer; drawing ...

  6. Cervical Cancer Stage IA

    Science.gov (United States)

    ... hyphen, e.g. -historical Searches are case-insensitive Cervical Cancer Stage IA Add to My Pictures View /Download : ... 1500x1200 View Download Large: 3000x2400 View Download Title: Cervical Cancer Stage IA Description: Stage IA1 and IA2 cervical ...

  7. Beyond Erikson's Eight Stages.

    Science.gov (United States)

    Whitney, Ruth

    1979-01-01

    Erik Erikson has described eight stages of the healthy personality. This essay offers a revised version of the eight stages. Although most individuals develop through the eight stages, each is personally unique because patterns of fluctuation between safety and growth differ from one individual to another. (Author)

  8. Ovarian Cancer Stage II

    Science.gov (United States)

    ... hyphen, e.g. -historical Searches are case-insensitive Ovarian Cancer Stage II Add to My Pictures View /Download : ... 1650x675 View Download Large: 3300x1350 View Download Title: Ovarian Cancer Stage II Description: Three-panel drawing of stage ...

  9. Ovarian Cancer Stage IIIC

    Science.gov (United States)

    ... hyphen, e.g. -historical Searches are case-insensitive Ovarian Cancer Stage IIIC Add to My Pictures View /Download : ... 1530x1350 View Download Large: 3060x2700 View Download Title: Ovarian Cancer Stage IIIC Description: Drawing of stage IIIC shows ...

  10. Ovarian Cancer Stage I

    Science.gov (United States)

    ... hyphen, e.g. -historical Searches are case-insensitive Ovarian Cancer Stage I Add to My Pictures View /Download : ... 1650x675 View Download Large: 3300x1350 View Download Title: Ovarian Cancer Stage I Description: Three-panel drawing of stage ...

  11. Cetuximab, Cisplatin, and Radiation Therapy in Treating Patients With Stage IB, Stage II, Stage III, or Stage IVA Cervical Cancer

    Science.gov (United States)

    2014-12-29

    Cervical Adenocarcinoma; Cervical Adenosquamous Carcinoma; Cervical Small Cell Carcinoma; Cervical Squamous Cell Carcinoma; Stage IB Cervical Cancer; Stage IIA Cervical Cancer; Stage IIB Cervical Cancer; Stage III Cervical Cancer; Stage IVA Cervical Cancer

  12. Staged electrostatic precipitator

    Science.gov (United States)

    Miller, Stanley J.; Almlie, Jay C.; Zhuang, Ye

    2016-03-01

    A device includes a chamber having an air inlet and an air outlet. The device includes a plurality of stages including at least a first stage adjacent a second stage. The plurality of stages are disposed in the chamber and each stage has a plurality of discharge electrodes disposed in an interior region and is bounded by an upstream baffle on an end proximate the air inlet and bounded by a downstream baffle on an end proximate the air outlet. Each stage has at least one sidewall between the upstream baffle and the downstream baffle. The sidewall is configured as a collection electrode and has a plurality of apertures disposed along a length between the upstream baffle and the downstream baffle. The upstream baffle of the first stage is positioned in staggered alignment relative to the upstream baffle of the second stage and the downstream baffle of the first stage are positioned in staggered alignment relative to the downstream baffle of the second stage.

  13. Pantex staging study near-term alternatives

    Energy Technology Data Exchange (ETDEWEB)

    Madden, M.S.; Adickes, M.D.; Hostick, C.J.; Nealey, S.M.; Smith, B.W.

    1992-12-01

    As the result of bilateral treaties to reduce the number of weapons in the nuclear stockpile, the US Department of Energy must now address the requirements for additional storage of the plutonium components (pits) from the retired weapons at Pantex until the components` final disposition. Because of the critical need to take action, Pantex has initiated two related efforts: Project Stage Right and this Staging Study. While support of Project Stage Right is a key objective of this study, the scope covers a broader range of activities and aspects of the pit staging problem. This study provides estimates of worker radiation exposures under the current scenario as well as estimated radiation exposure for workers under four alternative staging scenarios. An important objective of this study also identifies and recommends for future study other activities related to staging where radiation safety and overall efficiency can be improved.

  14. Pantex staging study near-term alternatives

    Energy Technology Data Exchange (ETDEWEB)

    Madden, M.S.; Adickes, M.D.; Hostick, C.J.; Nealey, S.M.; Smith, B.W.

    1992-12-01

    As the result of bilateral treaties to reduce the number of weapons in the nuclear stockpile, the US Department of Energy must now address the requirements for additional storage of the plutonium components (pits) from the retired weapons at Pantex until the components' final disposition. Because of the critical need to take action, Pantex has initiated two related efforts: Project Stage Right and this Staging Study. While support of Project Stage Right is a key objective of this study, the scope covers a broader range of activities and aspects of the pit staging problem. This study provides estimates of worker radiation exposures under the current scenario as well as estimated radiation exposure for workers under four alternative staging scenarios. An important objective of this study also identifies and recommends for future study other activities related to staging where radiation safety and overall efficiency can be improved.

  15. Staging for vaginal cancer.

    Science.gov (United States)

    Rajaram, Shalini; Maheshwari, Amita; Srivastava, Astha

    2015-08-01

    Vaginal cancer is a rare cancer comprising about 3% of all gynecologic cancers. Primary vaginal cancer should be carefully assigned as spread from cervix, vulva, and other metastatic tumors to vagina can occur. Although vaginal cancer traditionally occurs in older postmenopausal women, the incidence of high-risk human papillomavirus (HPV)-induced cancers is increasing in younger women. Squamous cell carcinoma is still the most common histopathologic type followed by adenocarcinoma. With decreasing use of diethylstilbestrol in pregnancy, non-diethylstilbestrol-associated cancers are described. The Federation Internationale de Gynecologie et d'Obstetrique (FIGO) staging of vaginal cancer (2009) follows the same rules as cervical cancer; it is clinically staged and allows the use of routine investigative modalities for staging. Although FIGO encourages the use of advanced imaging modalities, such as computed tomography, magnetic resonance imaging (MRI), and positron emission tomography (PET), to guide therapy, the imaging findings may not be used to change or reassign the stage. TNM staging is the pathologic staging system proposed by the American Joint Committee on Cancer, and information available from examination of the resected specimen, including pelvic and inguinal lymph nodes, may be used for staging. Copyright © 2015 Elsevier Ltd. All rights reserved.

  16. Staged bilateral carotid endarterectomy

    DEFF Research Database (Denmark)

    Schroeder, T; Sillesen, H; Engell, Hans Christian

    1986-01-01

    In a series of 56 staged bilateral carotid endarterectomies, new neurologic symptoms developed in 5% and 20% following the first and second procedure, respectively. All complications were transient or minor. The incidence of postendarterectomy hypertension was significantly higher following...

  17. Late-Stage Caregiving

    Science.gov (United States)

    ... resources, care and ways to engage in meaningful connections. During the late stages, your role as a ... drinks. This will help you track the person's natural routine, and then you can plan a schedule. ...

  18. Multiple Stages 2

    DEFF Research Database (Denmark)

    Andreasen, John

    Multiple stages 2: theatrical futures, set design, community plays, cultural capitals, democracy & drama, WWII dramas, performance on adoption, promenade about emigration, qualities in political theatre, performance analysis, dramaturgical education, Toulmin Variations...

  19. Multiple Stages 2

    DEFF Research Database (Denmark)

    Andreasen, John

    Multiple stages 2: theatrical futures, set design, community plays, cultural capitals, democracy & drama, WWII dramas, performance on adoption, promenade about emigration, qualities in political theatre, performance analysis, dramaturgical education, Toulmin Variations...

  20. Staging of Lung Cancer

    Science.gov (United States)

    ... 2010. Online Version Reviewed September 2013 ATS Patient Education Series © 2010 American Thoracic Society LIVER BONE www.thoracic.org ATS PATIENT INFORMATION SERIES How will my lung cancer be staged? ...

  1. Bioimpedance Spectroscopy in Detecting Lower-Extremity Lymphedema in Patients With Stage I, Stage II, Stage III, or Stage IV Vulvar Cancer Undergoing Surgery and Lymphadenectomy

    Science.gov (United States)

    2016-02-09

    Lymphedema; Perioperative/Postoperative Complications; Stage IA Vulvar Cancer; Stage IB Vulvar Cancer; Stage II Vulvar Cancer; Stage IIIA Vulvar Cancer; Stage IIIB Vulvar Cancer; Stage IIIC Vulvar Cancer; Stage IVA Vulvar Cancer; Stage IVB Vulvar Cancer

  2. Multiple stage railgun

    Science.gov (United States)

    Hawke, Ronald S.; Scudder, Jonathan K.; Aaland, Kristian

    1982-01-01

    A multiple stage magnetic railgun accelerator (10) for accelerating a projectile (15) by movement of a plasma arc (13) along the rails (11,12). The railgun (10) is divided into a plurality of successive rail stages (10a-n) which are sequentially energized by separate energy sources (14a-n) as the projectile (15) moves through the bore (17) of the railgun (10). Propagation of energy from an energized rail stage back towards the breech end (29) of the railgun (10) can be prevented by connection of the energy sources (14a-n) to the rails (11,12) through isolation diodes (34a-n). Propagation of energy from an energized rail stage back towards the breech end of the railgun can also be prevented by dividing the rails (11,12) into electrically isolated rail sections (11a-n, 12a-n). In such case means (55a-n) are used to extinguish the arc at the end of each energized stage and a fuse (31) or laser device (61) is used to initiate a new plasma arc in the next energized rail stage.

  3. Chemotherapy Toxicity On Quality of Life in Older Patients With Stage I, Stage II, Stage III, or Stage IV Ovarian Epithelial, Primary Peritoneal Cavity, or Fallopian Tube Cancer

    Science.gov (United States)

    2016-02-09

    Stage I Ovarian Cancer; Stage IA Fallopian Tube Cancer; Stage IB Fallopian Tube Cancer; Stage IC Fallopian Tube Cancer; Stage II Ovarian Cancer; Stage IIA Fallopian Tube Cancer; Stage IIB Fallopian Tube Cancer; Stage IIC Fallopian Tube Cancer; Stage III Ovarian Cancer; Stage III Primary Peritoneal Cancer; Stage IIIA Fallopian Tube Cancer; Stage IIIB Fallopian Tube Cancer; Stage IIIC Fallopian Tube Cancer; Stage IV Fallopian Tube Cancer; Stage IV Ovarian Cancer; Stage IV Primary Peritoneal Cancer

  4. Importance of Gait Training

    Science.gov (United States)

    ... amputation exercises done under the supervision of a physical therapist, the initial training is provided by the prosthetist ... this stage, it is best to involve a physical therapist for regular gait training sessions. Once it is ...

  5. Black Brant X third stage dispersion dynamics

    Science.gov (United States)

    Montag, W. H.; Maksimovic, V. M.; Lindahl, J. E.

    1982-01-01

    The successful development of the Black Brant X (BBX) launch vehicle resulted from the application of a gyroscopically stabilized, unguided third stage motor configuration. Design analyses indicated sufficient gyroscopic stability and acceptable impact dispersion could be realized by optimizing second/third stage separation time. By flying an unguided third stage motor, significant program cost savings were realized. One flight test and two operational missions demonstrated the feasibility of utilizing gyroscopic stability to achieve satisfactory trajectory dispersion on a high performance rocket. A detailed assessment of the major dispersion contributors identified for the first three BBX missions is presented, offering important insight into the dispersion sensitivity of unguided, spin-stabilized flight.

  6. Lymph node staging in prostate cancer.

    Science.gov (United States)

    Sankineni, Sandeep; Brown, Anna M; Fascelli, Michele; Law, Yan Mee; Pinto, Peter A; Choyke, Peter L; Turkbey, Baris

    2015-05-01

    Nodal staging is important in prostate cancer treatment. While surgical lymph node dissection is the classic method of determining whether lymph nodes harbor malignancy, this is a very invasive technique. Current noninvasive approaches to identifying malignant lymph nodes are limited. Conventional imaging methods rely on size and morphology of lymph nodes and have notoriously low sensitivity for detecting malignant nodes. New imaging techniques such as targeted positron emission tomography (PET) imaging and magnetic resonance lymphography (MRL) with iron oxide particles are promising for nodal staging of prostate cancer. In this review, the strengths and limitations of imaging techniques for lymph node staging of prostate cancer are discussed.

  7. How Is Ovarian Cancer Staged?

    Science.gov (United States)

    ... Cancer Early Detection, Diagnosis, and Staging How Is Ovarian Cancer Staged? Staging is the process of finding out ... Ask Your Doctor About Ovarian Cancer? More In Ovarian Cancer About Ovarian Cancer Causes, Risk Factors, and Prevention ...

  8. Stages of Oropharyngeal Cancer

    Science.gov (United States)

    ... of the oropharynx . These abnormal cells may become cancer and spread into nearby normal tissue . Stage 0 is also called carcinoma in situ . Enlarge Tumor sizes. The size of a tumor may be compared to the size of a pea (1 cm), peanut (2 cm), grape (3 cm), walnut (4 cm), lime (5 cm), ...

  9. Stages of Hypopharyngeal Cancer

    Science.gov (United States)

    ... of the hypopharynx . These abnormal cells may become cancer and spread into nearby normal tissue . Stage 0 is also called carcinoma in situ . Enlarge Tumor sizes. The size of a tumor may be compared to the size of a pea (1 cm), peanut (2 cm), grape (3 cm), walnut (4 cm), lime (5 cm), ...

  10. World Stage Design

    Index Scriptorium Estoniae

    2005-01-01

    12-19. III Torontos rahvusvaheline lavakujunduse, kostüümi ning valgus- ja helikujunduse näitus, mis toimub samaaegselt OISTATi (International Organization of Scenographers, Theatre Architects and Technicians) maailmakongressiga ja USITT (United States Institute for Theatre Technology) üritustega (konverents, Stage Expo). Eestit esindab lavakujunduse kategoorias Lilja Blumenfeld-Luhse

  11. Composers on stage

    DEFF Research Database (Denmark)

    Groth, Sanne Krogh

    A trend on the scene of contemporary music is composers going on stage, performing their pieces themselves. Within a discourse of popular music, this is more the rule than exception, but when it comes to the context of contemporary scored music, the historical and aesthetic context differs, and s...

  12. World Stage Design

    Index Scriptorium Estoniae

    2005-01-01

    12-19. III Torontos rahvusvaheline lavakujunduse, kostüümi ning valgus- ja helikujunduse näitus, mis toimub samaaegselt OISTATi (International Organization of Scenographers, Theatre Architects and Technicians) maailmakongressiga ja USITT (United States Institute for Theatre Technology) üritustega (konverents, Stage Expo). Eestit esindab lavakujunduse kategoorias Lilja Blumenfeld-Luhse

  13. Multi-stage cleaning plant

    Energy Technology Data Exchange (ETDEWEB)

    Kullendorff, A.; Wikner, J.

    1980-12-09

    A cleaning plant positioned within an annular fluidized bed combustion chamber is divided into a plurality of separate cleaning stages, wherein a first stage is located adjacent the fluidized bed and additional stages are arranged within the first stage. Each stage comprises a plurality of separate cleaning devices which act in parallel, while cleaning devices of different stages act in series to remove debris from the combustion gases that exit from the fluidized bed combustion chamber.

  14. Implicit stage topics

    Directory of Open Access Journals (Sweden)

    Karen Lahousse

    2008-04-01

    Full Text Available Il a souvent été proposé que les éléments spatio-temporels en position initiale de phrase spécifient le cadre de l’événement dénoté par la proposition et ont une interprétation thématique ou topicale. Alors que les topiques spatio-temporels explicites ont souvent été étudiés, Erteschik-Schir (1997, 1999 propose l’idée que les topiques spatio-temporels, ou topiques scéniques (stage topics peuvent aussi être implicites.Dans cet article, nous offrons des arguments en faveur de la notion de topique scénique implicite. Nous montrons qu’un certain nombre de cas d’inversion nominale en français, une configuration syntaxique qui est favorisée par la présence d’un topique scénique explicite, s’expliquent par la présence d’un topique scénique implicite. Le fait que les topiques scéniques implicites interagissent avec la structure syntaxique de la même façon que les topiques scéniques explicites constitue un argument empirique en faveur de leur existence.It has often been proposed that sentence-initial spatio-temporal elements specify the frame in which the whole proposition takes place and are topical (i.e. thematic. Whereas considerable attention has been paid to explicit spatio-temporal topics, Erteschik-Shir (1997, 1999 argues that spatio-temporal topics, or stage topics, can also be implicit.In this article we provide evidence in favour of the notion of implicit stage topic. We show that a certain number of nominal inversion cases in French, a syntactic configuration which is triggered by the presence of an explicit stage topic, are explained by the presence of an implicit stage topic. The fact that implicit stage topics interact with syntactic structure the same way explicit stage topics do constitutes a strong empirical argument in favour of their existence.

  15. Evaluation of stage acoustics in Seoul Arts Center Concert Hall by measuring stage support.

    Science.gov (United States)

    Jeon, Jin Yong; Barron, Michael

    2005-01-01

    Stage acoustics is an important characteristic for concert halls, both for the acoustic quality on stage and for the audience. However, relatively little research has been conducted into the question. This study was based on the investigation of an actual concert hall stage, that of the Seoul Arts Center Concert Hall in Korea. The stage acoustics was evaluated in the actual hall, and with two models: a 1:25 scale model and a computer model. The study was based on the stage support parameter ST1 proposed by Gade as a measure of support for individual performers [Acustica 65, 193-203 (1989)]. The variation of support was measured on the empty stage of the actual hall and in the two models. The effect of musicians on stage, the effect of moving the orchestra, the effect of ceiling height and of stage-wall profile were also investigated. Conclusions are drawn both relating to the Seoul Concert Hall stage and stages in general.

  16. Operational Strategies for Single-Stage Crossdocks

    OpenAIRE

    Wang, Jiana-Fu

    2010-01-01

    Because of the growing importance of hub-and-spoke operations in the trucking industry, crossdocking has become an important and effective tool to transfer freight. Companies like Wal-Mart, Costco and Home Depot are using this kind of facility in their logistics operations. In these crossdocks, efficiently operating them, thereby reducing unnecessary waiting and staging congestion for freight and workers is an important issue for managers. This dissertation uses real-time information...

  17. Staging Sociotechnical Spaces

    DEFF Research Database (Denmark)

    Clausen, Christian; Yoshinaka, Yutaka

    2007-01-01

    The management of innovation and product development is increasingly facing complex challenges of staging design processes across heterogeneous organisational spaces, with multiple actor-concerns and sources of knowledge. This paper addresses how insights from the Actor-Network Theory and political...... process theory may contribute to a reflexive understanding of design as the staging of socio-technical relations and processes cutting across boundaries of diverse organisational, political and knowledge domains. This idea is pursued through the notion of ‘socio-technical spaces’. Socio-technical space...... of product development. The concept of socio-technical spaces is further illustrated through actual examples from industry dealing with early conceptualisation in product development and the role played by management concepts in the configuration of spaces....

  18. Staging interrail mobilities

    DEFF Research Database (Denmark)

    Jensen, Martin Trandberg; Gyimóthy, Szilvia; Jensen, Ole B.

    2016-01-01

    This article applies the multiscalar ‘staging mobilities’ framework from the emergent subfield of mobilities design to analyse an enduring European rail travel phenomenon, interrail. This discussion extends and contributes to tourism mobilities research. Second, the article enriches previous...... and seat reservations. To reach these aims, the research design intertwines multi-sited ethnography, netnography, survey and interviews. The conclusion offers theoretical reflections pertaining to the role of mobilities designs and methodical hybrids in tourism mobilities research....

  19. Modeling the three stages in HIV infection.

    Science.gov (United States)

    Hernandez-Vargas, Esteban A; Middleton, Richard H

    2013-03-07

    A typical HIV infection response consists of three stages: an initial acute infection, a long asymptomatic period and a final increase in viral load with simultaneous collapse in healthy CD4+T cell counts. The majority of existing mathematical models give a good representation of either the first two stages or the last stage of the infection. Using macrophages as a long-term active reservoir, a deterministic model is proposed to explain the three stages of the infection including the progression to AIDS. Simulation results illustrate how chronic infected macrophages can explain the progression to AIDS provoking viral explosion. Further simulation studies suggest that the proposed model retains its key properties even under moderately large parameter variations. This model provides important insights on how macrophages might play a crucial role in the long term behavior of HIV infection. Crown Copyright © 2012. Published by Elsevier Ltd. All rights reserved.

  20. Primary staging of prostate cancer

    Energy Technology Data Exchange (ETDEWEB)

    Jager, G.J. [Dept. of Radiology, Univ. Hospital, Nijmegen (Netherlands); Barentz, J.O. [Dept. of Radiology, Univ. Hospital, Nijmegen (Netherlands); Ruijter, E.T.G. [Dept. of Urology, Univ. Hospital, Nijmegen (Netherlands)]|[Dept. of Pathology, Univ. Hospital, Nijmegen (Netherlands); Rosette, J.J.M.C.H. de la [Dept. of Urology, Univ. Hospital, Nijmegen (Netherlands); Oosterhof, G.O.N. [Dept. of Urology, Univ. Hospital, Nijmegen (Netherlands)

    1996-04-01

    Staging prostate cancer is a systematic classification of the extent of disease based on clinical and pathological criteria. Despite general acceptance of the TNM staging system, a lot of controversy and uncertainty with respect to staging still exists. This paper gives an overview of differnt staging modalities and emphasizes the need for incorporation of prognostic factors, such as tumour grade and volume, in the staging system. (orig.)

  1. Composites for Exploration Upper Stage

    Science.gov (United States)

    Fikes, J. C.; Jackson, J. R.; Richardson, S. W.; Thomas, A. D.; Mann, T. O.; Miller, S. G.

    2016-01-01

    The Composites for Exploration Upper Stage (CEUS) was a 3-year, level III project within the Technology Demonstration Missions program of the NASA Space Technology Mission Directorate. Studies have shown that composites provide important programmatic enhancements, including reduced weight to increase capability and accelerated expansion of exploration and science mission objectives. The CEUS project was focused on technologies that best advanced innovation, infusion, and broad applications for the inclusion of composites on future large human-rated launch vehicles and spacecraft. The benefits included near- and far-term opportunities for infusion (NASA, industry/commercial, Department of Defense), demonstrated critical technologies and technically implementable evolvable innovations, and sustained Agency experience. The initial scope of the project was to advance technologies for large composite structures applicable to the Space Launch System (SLS) Exploration Upper Stage (EUS) by focusing on the affordability and technical performance of the EUS forward and aft skirts. The project was tasked to develop and demonstrate critical composite technologies with a focus on full-scale materials, design, manufacturing, and test using NASA in-house capabilities. This would have demonstrated a major advancement in confidence and matured the large-scale composite technology to a Technology Readiness Level 6. This project would, therefore, have bridged the gap for providing composite application to SLS upgrades, enabling future exploration missions.

  2. Whole-body staging of malignant melanoma. Advantages, limitations and current importance of PET-CT, whole-body MRI and PET-MRI; Ganzkoerperdiagnostik beim malignen Melanom. Vorteile, Grenzen und aktueller Stellenwert von PET-CT, GK-MRT und PET-MRT

    Energy Technology Data Exchange (ETDEWEB)

    Pfannenberg, C.; Schwenzer, N. [Eberhard-Karls-Universitaet Tuebingen, Abteilung Diagnostische und Interventionelle Radiologie, Tuebingen (Germany)

    2015-01-16

    Cross-sectional imaging methods are currently the standard methods for staging of advanced melanoma. The former time-consuming and expensive multimodality approach is increasingly being replaced by novel whole-body (WB) staging methods, such as 18F-fluorodeoxyglucose positron emission tomography/computed tomography ({sup 18}F-FDG-PET-CT) and whole-body magnetic resonance imaging (WBMRI) because they offer a complete head-to-toe coverage of the patient in a single examination with an accurate and sensitive detection of tumor spread. Several studies in patients with advanced melanoma revealed that PET-CT is more sensitive and specific than conventional modalities, such as CT alone resulting in a change of management in up to 30 % of cases. Due to the limited sensitivity of PET for lesions smaller than 1 cm, PET-CT is not useful for the initial work-up of patients with stage I and II melanoma but has proven to be superior for detection of distant metastases, which is essential prior to surgical metastasectomy. If PET-CT is not available WB-CT or WB-MRI can alternatively be used and WB-MRI including diffusion-weighted imaging (DWI) has become a real alternative for staging of melanoma patients. So far, however, only few reports suffering from small numbers of cases and heterogeneous design have compared the diagnostic performance of WB-MRI and PET-CT. The preliminary results indicate a high overall diagnostic accuracy of both methods; however, these methods differ in organ-based detection rates: PET-CT was more accurate in N-staging and detection of lung and soft tissue metastases whereas WB-MRI was superior in detecting liver, bone and brain metastases. The value of PET-MRI for staging of advanced melanoma is the subject of ongoing clinical studies. (orig.) [German] Schnittbildmethoden sind heute der Standard bei der Ausbreitungsdiagnostik ab Stadium III des malignen Melanoms. Das fruehere zeit- und kostenaufwendige multimodale Konzept wird heute durch Ganzkoerper

  3. Initial stages of Bose-Einstein condensation

    NARCIS (Netherlands)

    Stoof, H.T.C.

    1997-01-01

    We present the quantum theory for the nucleation of Bose-Einstein condensation in a dilute atomic Bose gas. This quantum theory has the important advantage that both the kinetic and coherent stages of the nucleation process can be described in a unified way by a single Fokker-Planck equation.

  4. Initial stages of Bose-Einstein condensation

    NARCIS (Netherlands)

    Stoof, H.T.C.

    2001-01-01

    We present the quantum theory for the nucleation of Bose-Einstein condensation in a dilute atomic Bose gas. This quantum theory confirms the results of the semiclassical treatment, but has the important advantage that both the kinetic and coherent stages of the nucleation process can now be describe

  5. STAGE OF TEXTILE RECYCLE WASTE IN ROMANIA

    OpenAIRE

    TRIPA Simona

    2014-01-01

    Aim of this article is to examine the stage of textile recycle waste in Romania. For this purpose were analyzed the main sources of textile waste from Romania (industry of manufacture of textiles, wearing apparel, leather and related products, imports of textiles, clothing and footwear and imports of second hand clothing) and also evolution of the quantity of textile waste in Romania. The benefits (economic and environmental) of the collection and recycling of waste and the legislation ...

  6. Staging in Patients with Small-Cell Lung Carcinoma; PET-CT versus Standard Staging Procedures

    Directory of Open Access Journals (Sweden)

    Burcu Yalçın

    2016-12-01

    Full Text Available Objective: The most important factor for accurate treatment of patients with small cell lung carcinoma (SCLC is accuracy of the initial staging. The aim of this study was to determine how often patients, staged as local or local-advanced disease by standard staging procedures (SSPs, would be staged to have a metastatic disease based on the findings of the positron emission tomography–computed tomography (PET-CT scan. Methods: Patients with SCLC who were staged as I, II, or III disease by SSPs (according to the American Joint Committee on Cancer Staging, 7th edition formed the study population. SSPs included computed tomography of chest, abdomen, brain (or magnetic resonance imaging of brain, and bone scintigraphy. These patients were re-staged with 18F-FDG PET-CT scan. Results: Between 2013 and 2015, 27 patients were prospectively studied. Of these patients, 92.5% were male and the median age was 61. Among 27 patients, distant metastasis was detected by PET-CT in 7 (25.9% patients. Two of 7 patients were determined as stage IIIA by SSPs and 5 of 17 patients that were determined as stage IIIB by SSPs were upstaged to metastatic disease by PET-CT. All of the 7 patients had bone metastasis by PET-CT. But bone metastasis could not be detected with bone scintigraphy. Conclusion: PET-CT detected distant metastasis in one quarter of SCLC stage III patients by SSPs. Patients who staged local-advanced SCLC with CT of the chest have to be assessed by PET-CT for extracranial distant metastasis.

  7. CalCOFI Egg Stages

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Egg morphological developmental stage for eggs of selected species captured in CalCOFI icthyoplankton nets. Sequential developmental stages are described by Moser...

  8. Staged urethroplasty: indications and techniques.

    Science.gov (United States)

    Secrest, Charles L

    2002-05-01

    There is still a place for staged urethroplasty. There are some indications for staged urethral reconstruction such as strictures associated with chronic inflammation, fistula, false passage, urethral stones, urethral diverticula, abscess, failed prior repair, complicated hypospadias, severe trauma, neurologic diseases, extensive BXO strictures and long strictures. Staging a urethroplasty should not be considered a step backwards rather instead we should learn from experience and realize there are some patients who are too complex to reconstruct in a single stage.

  9. The protection motivation theory within the stages of the transtheoretical model - stage-specific interplay of variables and prediction of exercise stage transitions.

    Science.gov (United States)

    Lippke, Sonia; Plotnikoff, Ronald C

    2009-05-01

    Two different theories of health behaviour have been chosen with the aim of theory integration: a continuous theory (protection motivation theory, PMT) and a stage model (transtheoretical model, TTM). This is the first study to test whether the stages of the TTM moderate the interrelation of PMT-variables and the mediation of motivation, as well as PMT-variables' interactions in predicting stage transitions. Hypotheses were tested regarding (1) mean patterns, stage pair-comparisons and nonlinear trends using ANOVAs; (2) prediction-patterns for the different stage groups employing multi-group structural equation modelling (MSEM) and nested model analyses; and (3) stage transitions using binary logistic regression analyses. Adults (N=1,602) were assessed over a 6 month period on their physical activity stages, PMT-variables and subsequent behaviour. (1) Particular mean differences and nonlinear trends in all test variables were found. (2) The PMT adequately fitted the five stage groups. The MSEM revealed that covariances within threat appraisal and coping appraisal were invariant and all other constrains were stage-specific, i.e. stage was a moderator. Except for self-efficacy, motivation fully mediated the relationship between the social-cognitive variables and behaviour. (3) Predicting stage transitions with the PMT-variables underscored the importance of self-efficacy. Only when threat appraisal and coping appraisal were high, stage movement was more likely in the preparation stage. Results emphasize stage-specific differences of the PMT mechanisms, and hence, support the stage construct. The findings may guide further theory building and research integrating different theoretical approaches.

  10. Deinstitutionalising School Science: Implications of a Strong View of Situated Cognition.

    Science.gov (United States)

    Roth, Wolff-Michael; McGinn, Michelle K.

    1997-01-01

    Information processing models do not account for much of human competence in everyday scientific and lay contexts. Situated cognition models account better for competence in widely differing situations. In situated cognition models, the purpose of science education must be reconceived as preparing citizens to participate in public enactments of…

  11. Management of organisational changes in a case of de-institutionalisation.

    Science.gov (United States)

    Parlalis, Stavros K

    2011-01-01

    This paper seeks to explore the development of a discharge programme in one learning disability hospital in Scotland. The study aims to concentrate on organisational developmental changes in that institution. The model of the management during the discharge programme was investigated. The aim of the study is to explore how the discharge programme developed, as seen under the lens of organisational change, in order to find out what kind of model of management is more suitable in similar programmes. A case study was employed. Data were collected by means of interviews. The interviews followed a structured format. The sample of the study had to be a purposive sample and the method of snowball sampling was used; finally, 28 interviews were conducted. A grounded approach was adopted for the data analysis. The software program QSR "NUD*IST" (version "N6") was used as a technical tool, in order to facilitate the data analysis. The findings of this study show that various management models were adopted in the four phases of the discharge programme. These different models represent a "quest" by the institution's management regarding the most appropriate model for managing the discharge programme. This study shows that this goes on continuously in organisations under transition until they settle down to a more permanent state. It was concluded that management models, which are composed of characteristics from the organic theory of organisational management, could apply in discharge programmes. The data gathered enabled the researcher to arrive at a model of management which is suitable for managing organisational changes in discharge programmes, the named "stakeholder management model".

  12. The Process of Deinstitutionalisation and Abolition of Restraint in the Social Care Home Dutovlje

    Directory of Open Access Journals (Sweden)

    Karmen Orel

    2012-12-01

    Full Text Available Deinstitutionalization is the process that includes practical changes, and transforming the treatment of persons with mental health problems. This process counteracts the harmful effects of living in an institution. The basic steps start within the institution by strengthening the relationship of power in favour of the residents. This is very closely related to the abolition of restraint methods. The change in power relations between the actors of deinstitutionalization is also connected with the legal system. The Mental Health Act has not brought the expected results, it is largely inconsistent with both the Social Security Act, the Regulations on standards and norms for social services, as well the code of ethical principles in social work as professional principles, methods and work procedures. The Mental Health Act gives the opportunity for using the methods of restraint in a social care home where, in addition to this unethical and inhumane approach to the tenant, puts workers in trouble. The authors mention some historical data of the opening of the institutions in the world and briefly introduce an example of good practice of the process of deinstitutionalization in the Social care home Dutovlje.

  13. De-institutionalisation in psychiatry – both sides of the coin

    African Journals Online (AJOL)

    The next two centuries, however, saw a radical change, with the development of institutional confinement as the principal way of dealing ... In some areas community resistance has emerged as a significant factor. • Urbanisation and smaller ...

  14. Tax Policies: Important for Outbound Investment

    Institute of Scientific and Technical Information of China (English)

    Li Zhen

    2010-01-01

    @@ Implementing "going out" strategy is a new stage of China's reform and opening up.To encourage and facilitate outbound investment of Chinese enterprises can not only be of great importance in making full use of international and domestic resources and market to help expand national economy,but also can be helpful for enterprises in the fierce international competition.

  15. Emergy and Its Importance

    Science.gov (United States)

    Emergy is an important quantity needed for public policy analysis that is based on a complex methodology. The intent of this Environmental Research Brief is to define emergy and its importance in a manner that is accessible to everyone with at least a high school education. Emer...

  16. Science on stage

    Science.gov (United States)

    Ciceri, Piera

    2017-04-01

    Pictures and diaries of the legendary Antarctic Expedition of sir E. Shackleton and his crew aboard the Endurance (1914/16) have become the starting point to learn about Natural Science, Earth Science and Climate Change. Students, 12 years old, were involved in hands on activities, took part to a network project, used interactive virtual labs, talked to university researchers on Skype and became the writers of a play. The theater was the place to act the story of Shackleton's expedition, to "stage" some scientific experiments and to tell to the audience about ice cores, climate change, physical and geographical characteristic of polar regions, thermal phenomena related to adaptations of polar animals, solar radiation at different latitude, day/night duration. The project was carried out from teachers of science, letters, geography and English in collaboration with the "Piccolo Teatro di Milano", the association "Scienza Under 18", researchers of the "Byrd Polar and Climate Research Center of Ohio State University" and of "M. Zucchelli Station" based in Antarctica. In our opinion drama activities improve both verbal and non-verbal communication skills and soft skills such as teamwork, responsibility and commitment. To be able to write and to act, students need a deep understanding of contents. To have an audience different from their own teachers and classmates and to interact with university researchers offer real tasks. The project aims to develop a relevant skill for the students: to become awareness citizens in a changing word.

  17. Science on stage

    CERN Multimedia

    2005-01-01

    During the opening ceremony, the audience was dazzled by a juggling show involving dramatic light effects. They also took away with them a teacher's sheet explaining some of the scientific concepts involved in juggling. Science teachers can sometimes be quite humorous when it comes to explaining serious matters, as those who took part in the 'Science on Stage' festival held at CERN from 21 to 25 November were able to see for themselves. The 500 or so participants from 27 different countries, mostly science teachers but also some university lecturers, science outreach specialists and students, had the opportunity to share their experience of the teaching of science. They also attended presentations and shows, took part in workshops and visited a fair with stands offering ideas on how to make school science lessons more appealing. The festival, organised by the EIROforum (a partnership between CERN, EFDA, ESA, ESO, EMBL, ESRF and ILL), marked the end of two years of projects for the promotion of science in vir...

  18. Bevacizumab, Cisplatin, Radiation Therapy, and Fluorouracil in Treating Patients With Stage IIB, Stage III, Stage IVA, or Stage IVB Nasopharyngeal Cancer

    Science.gov (United States)

    2014-04-21

    Stage II Squamous Cell Carcinoma of the Nasopharynx; Stage III Lymphoepithelioma of the Nasopharynx; Stage III Squamous Cell Carcinoma of the Nasopharynx; Stage IV Lymphoepithelioma of the Nasopharynx; Stage IV Squamous Cell Carcinoma of the Nasopharynx

  19. Life is a Stage

    DEFF Research Database (Denmark)

    Brynskov, Martin; Bouvin, Niels Olof; Christensen, Bent Guldbjerg

    2007-01-01

    . The resulting heterogeneous architecture is implemented using Adobe Flash Lite and Python running on Symbian smartphones, and a LAMP webservice backend. While the implementation is initially client-server-based, extensions for peer-to-peer networking are an important part of the architecture and are being...

  20. The three stages of magma ocean cooling

    Science.gov (United States)

    Warren, Paul H.

    1992-12-01

    Models of magma ocean (MO) cooling and crystallization can provide important constraints on MO plausibility for a given planet, on the origin of long term, stable crusts, and even on the origin of the solar system. Assuming the MO is initially extensive enough to have a mostly molten surface, its first stage of cooling is an era of radiative heat loss from the surface, with extremely rapid convection below, and no conductive layer in between. The development of the chill crust starts the second stage of MO cooling. Heat loss is now limited by conduction through the crust. The third stage of cooling starts when the near surface MO evolves compositionally to the point of saturation with feldspar. At this point, the cooling rate again precipitously diminishes, the rate of crustal thickness growth as a function of temperature suddenly increases. More work on incorporating chemical constraints into the evolving physical models of MO solidification would be worthwhile.

  1. FASTER: an unsupervised fully automated sleep staging method for mice

    OpenAIRE

    Sunagawa, GA; Sei, H; Shimba, S; Urade, Y; Ueda, HR

    2013-01-01

    Identifying the stages of sleep, or sleep staging, is an unavoidable step in sleep research and typically requires visual inspection of electroencephalography (EEG) and electromyography (EMG) data. Currently, scoring is slow, biased and prone to error by humans and thus is the most important bottleneck for large-scale sleep research in animals. We have developed an unsupervised, fully automated sleep staging method for mice that allows less subjective and high-throughput evaluation of sleep. ...

  2. DNA Import into Mitochondria.

    Science.gov (United States)

    Konstantinov, Yu M; Dietrich, A; Weber-Lotfi, F; Ibrahim, N; Klimenko, E S; Tarasenko, V I; Bolotova, T A; Koulintchenko, M V

    2016-10-01

    In recent decades, it has become evident that the condition for normal functioning of mitochondria in higher eukaryotes is the presence of membrane transport systems of macromolecules (proteins and nucleic acids). Natural competence of the mitochondria in plants, animals, and yeasts to actively uptake DNA may be directly related to horizontal gene transfer into these organelles occurring at much higher rate compared to the nuclear and chloroplast genomes. However, in contrast with import of proteins and tRNAs, little is known about the biological role and molecular mechanism underlying import of DNA into eukaryotic mitochondria. In this review, we discuss current state of investigations in this area, particularly specificity of DNA import into mitochondria and its features in plants, animals, and yeasts; a tentative mechanism of DNA import across the mitochondrial outer and inner membranes; experimental data evidencing several existing, but not yet fully understood mechanisms of DNA transfer into mitochondria. Currently available data regarding transport of informational macromolecules (DNA, RNA, and proteins) into the mitochondria do not rule out that the mechanism of protein and tRNA import as well as tRNA and DNA import into the mitochondria may partially overlap.

  3. Controversies in Surgical Staging of Endometrial Cancer

    Directory of Open Access Journals (Sweden)

    R. Seracchioli

    2010-01-01

    Full Text Available Endometrial cancer is the most common gynaecological malignancy and its incidence is increasing. In 1998, international federation of gynaecologists and obstetricians (FIGO required a change from clinical to surgical staging in endometrial cancer, introducing pelvic and paraaortic lymphadenectomy. This staging requirement raised controversies around the importance of determining nodal status and impact of lymphadenectomy on outcomes. There is agreement about the prognostic value of lymphadenectomy, but its extent, therapeutic value, and benefits in terms of survival are still matter of debate, especially in early stages. Accurate preoperative risk stratification can guide to the appropriate type of surgery by selecting patients who benefit of lymphadenectomy. However, available preoperative and intraoperative investigations are not highly accurate methods to detect lymph nodes and a complete surgical staging remains the most precise method to evaluate extrauterine spread of the disease. Laparotomy has always been considered the standard approach for endometrial cancer surgical staging. Traditional and robotic-assisted laparoscopic techniques seem to provide equivalent results in terms of disease-free survival and overall survival compared to laparotomy. These minimally invasive approaches demonstrated additional benefits as shorter hospital stay, less use of pain killers, lower rate of complications and improved quality of life.

  4. American coal imports 2015

    Energy Technology Data Exchange (ETDEWEB)

    Frank Kolojeski [TransGlobal Ventures Corp. (United States)

    2007-09-15

    As 2007 ends, the US coal industry passes two major milestones - the ending of the Synfuel tax break, affecting over 100M st annually, and the imposition of tighter and much more expensive safety measures, particularly in deep mines. Both of these issues, arriving at a time of wretched steam coal price levels, promise to result in a major shake up in the Central Appalachian mining sector. The report utilizes a microeconomic regional approach to determine whether either of these two schools of thought have any validity. Transport, infrastructure, competing fuels and regional issues are examined in detail and this forecasts estimates coal demand and imports on a region by region basis for the years 2010 and 2015. Some of the major highlights of the forecast are: Import growth will be driven by steam coal demand in the eastern and southern US; Transport will continue to be the key driver - we believe that inland rail rates will deter imports from being railed far inland and that the great majority of imports will be delivered directly by vessel, barge or truck to end users; Colombian coal will be the overwhelmingly dominant supply source and possesses a costs structure to enable it to compete with US-produced coal in any market conditions; Most of the growth will come from existing power plants - increasing capacity utilization at existing import facilities and other plants making investments to add imports to the supply portfolio - the growth is not dependent upon a lot of new coal fired capacity being built. Contents of the report are: Key US market dynamics; International supply dynamics; Structure of the US coal import market; and Geographic analysis.

  5. Staged membrane oxidation reactor system

    Science.gov (United States)

    Repasky, John Michael; Carolan, Michael Francis; Stein, VanEric Edward; Chen, Christopher Ming-Poh

    2013-04-16

    Ion transport membrane oxidation system comprising (a) two or more membrane oxidation stages, each stage comprising a reactant zone, an oxidant zone, one or more ion transport membranes separating the reactant zone from the oxidant zone, a reactant gas inlet region, a reactant gas outlet region, an oxidant gas inlet region, and an oxidant gas outlet region; (b) an interstage reactant gas flow path disposed between each pair of membrane oxidation stages and adapted to place the reactant gas outlet region of a first stage of the pair in flow communication with the reactant gas inlet region of a second stage of the pair; and (c) one or more reactant interstage feed gas lines, each line being in flow communication with any interstage reactant gas flow path or with the reactant zone of any membrane oxidation stage receiving interstage reactant gas.

  6. Staged Repository Development Programmes

    Energy Technology Data Exchange (ETDEWEB)

    Isaacs, T

    2003-10-01

    Programs to manage and ultimately dispose of high-level radioactive wastes are unique from scientific and technological as well as socio-political aspects. From a scientific and technological perspective, high-level radioactive wastes remain potentially hazardous for geological time periods-many millennia-and scientific and technological programs must be put in place that result in a system that provides high confidence that the wastes will be isolated from the accessible environment for these many thousands of years. Of course, ''proof'' in the classical sense is not possible at the outset, since the performance of the system can only be known with assurance, if ever, after the waste has been emplaced for those geological time periods. Adding to this challenge, many uncertainties exist in both the natural and engineered systems that are intended to isolate the wastes, and some of the uncertainties will remain regardless of the time and expense in attempting to characterize the system and assess its performance. What was perhaps underappreciated in the early days of waste management and repository program development were the unique and intense reactions that the institutional, political, and public bodies would have to repository program development, particularly in programs attempting to identify and then select sites for characterization, design, licensing, and ultimate development. Reactions in most nations were strong, focused, unrelenting, and often successful in hindering, derailing, and even stopping national repository programs. The reasons for such reactions and the measures to successfully respond to them are still evolving and continue to be the focus of many national program and political leaders. Adaptive Staging suggests an approach to repository program development that reflects the unique challenges associated with the disposal of high-level radioactive waste. The step-wise, incremental, learn-as-you-go approach is intended to

  7. Kohlberg and Piaget on Stages and Moral Reasoning.

    Science.gov (United States)

    Carpendale, Jeremy I. M.

    2000-01-01

    Maintains that although Kohlberg emphasized the importance of perspective taking in moral reasoning, his view of developmental stages is inconsistent with this position. Argues that a modification of Kohlberg's conception of stages drawing on Piagetian theory would result in a view of moral reasoning as a process of coordinating all perspectives…

  8. Carboplatin and Paclitaxel With or Without Cisplatin and Radiation Therapy in Treating Patients With Stage I, Stage II, Stage III, or Stage IVA Endometrial Cancer

    Science.gov (United States)

    2017-08-23

    Endometrial Clear Cell Adenocarcinoma; Endometrial Serous Adenocarcinoma; Stage IA Uterine Corpus Cancer; Stage IB Uterine Corpus Cancer; Stage II Uterine Corpus Cancer; Stage IIIA Uterine Corpus Cancer; Stage IIIB Uterine Corpus Cancer; Stage IIIC Uterine Corpus Cancer; Stage IVA Uterine Corpus Cancer

  9. Stage-specific psychological determinants of stage transition

    NARCIS (Netherlands)

    Dijkstra, A.; Tromp, D; Conijn, B

    2003-01-01

    Objectives. The stages of change construct refers to the different psychological states people move through when they change their behaviour. However, the prediction that people in different stages of change need different sorts of interventions to stimulate the change process has scarcely been test

  10. The Importance of Education.

    Science.gov (United States)

    Echohawk, John

    1994-01-01

    The executive director of the Native American Rights Fund recounts his education experiences in the area of Indian law. Encourages native youth to pursue higher education even under financial pressures, noting the importance of education for native youth and their tribes in this era of Indian self-determination. (HTH)

  11. Minimal Pairs: Minimal Importance?

    Science.gov (United States)

    Brown, Adam

    1995-01-01

    This article argues that minimal pairs do not merit as much attention as they receive in pronunciation instruction. There are other aspects of pronunciation that are of greater importance, and there are other ways of teaching vowel and consonant pronunciation. (13 references) (VWL)

  12. The Importance of Ethos.

    Science.gov (United States)

    Oft-Rose, Nancy

    1989-01-01

    Discusses how studying the 1988 Presidential Debates reveals the importance of ethos in speaking and being elected to office. Asserts that the debates also offer an excellent opportunity to teach propaganda devices or fallacies. Provides two examples from the second Presidential Debate. (MM)

  13. Partner Performs More Important

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    Reporter: Would you please offer an introduction to exhibition development of Frankfurt? Michael von Zitzewitz: Mess Frankfurt GmbH has made great achievements in despite of dissatisfying economy in Europe. 364 million Euro of sales volume has made Mess Frankfurt GmbH become the 2nd largest world’s exhibition corporation, overseas sales is an important fortune resource for

  14. Exports to Imports

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    China covers ground as it attempts to balance imports and exports after a trade deficit in the first quarter As China gears up to rebalance its economy,a key factor will be weaning its reliance on exports.The vigorous efforts are paying off as the country reported a trade deficit in the first

  15. Import and nuclear size

    OpenAIRE

    Cohen-Fix, Orna

    2010-01-01

    The size of a cell’s nucleus is usually proportional to the size of the cell itself. How are the two linked? The answer lies, at least in part, in the import of one or more cytoplasmic cargoes into the nucleus.

  16. Ongoing problems concerning 7(th) TNM Staging System and Proposals for 8(th) TNM Staging System of Gastric Cancer.

    Science.gov (United States)

    Ilhan, Enver; Ureyen, Orhan; Meral, Ulvi Mehmet

    2016-01-01

    Because of different prognosis of gastric cancer patients with the same T and N stages, the impossibility of N3 staging in patients with fewer than 15 removed lymph nodes, and the presence of stage migration phenomenon, the 6(th) edition TNM Staging System for gastric cancer was updated to the 7(th) edition TNM staging system in 2009. Despite some opposing views, the superiority of the 7(th) edition TNM staging system compared to the 6(th) has been demonstrated in many studies. However, there are doubts about the 7(th) edition that it will reduce the stage migration phenomenon. The most important problem about the 7(th) TNM staging system is regarding subgroups N3a and N3b. The separation of N3 stage as N3a and N3b does not contribute to the TNM staging system. In conclusion, separate usage of N3a and N3b subgroups in the TNM staging system should be considered in the creation phase of the 8(th) edition.

  17. Ongoing problems concerning 7th TNM Staging System and Proposals for 8th TNM Staging System of Gastric Cancer

    Science.gov (United States)

    Ureyen, Orhan; Meral, Ulvi Mehmet

    2016-01-01

    Because of different prognosis of gastric cancer patients with the same T and N stages, the impossibility of N3 staging in patients with fewer than 15 removed lymph nodes, and the presence of stage migration phenomenon, the 6th edition TNM Staging System for gastric cancer was updated to the 7th edition TNM staging system in 2009. Despite some opposing views, the superiority of the 7th edition TNM staging system compared to the 6th has been demonstrated in many studies. However, there are doubts about the 7th edition that it will reduce the stage migration phenomenon. The most important problem about the 7th TNM staging system is regarding subgroups N3a and N3b. The separation of N3 stage as N3a and N3b does not contribute to the TNM staging system. In conclusion, separate usage of N3a and N3b subgroups in the TNM staging system should be considered in the creation phase of the 8th edition. PMID:28053675

  18. 长效和短效NO发生剂体内干预疟原虫红内期重要侵袭分子转录水平的观察%Transcription Levels of Important Invasive Molecules after Long-Acting and Short-Acting NO Donor to Interfere Plasmodium during Erythrocytic Stage in vivo

    Institute of Scientific and Technical Information of China (English)

    郑丽; 李银燕; 刘军; 潘艳艳; 李莹; 延娟; 曹雅明

    2011-01-01

    为探讨NO对疟原虫红内期侵袭相关分子MSP-1、AMA-1和RhopH complex转录水平的影响.通过雌性BALB/c小鼠腹腔感染1 ×106致死型约氏疟原虫P.yoelii 17XL,体内给予NO长效(NOC18)和短效( NOC5)发生剂进行干预后,纯化疟原虫成熟裂殖体,提取总RNA,通过Real-time PCR相对定量方法检测MSP-1、AMA-1和RhopH complex的转录水平.结果显示和正常感染组相比,NOC5处理后疟原虫侵入的关键分子MSP-1、AMA-1和RhopH complex的转录水平明显下降;而NOC18处理则未见这一现象.本研究结果提示NO抑制疟原虫侵袭关键分子的转录水平,进而可能下调疟原虫相应蛋白的表达,从而影响疟原虫的侵入过程.%The effects of NO on the transcription levels of correlated invasive molecules MSP-1, AMA-1, and RhopH complex during Plasmodium erythrocytic stage were investigated. Female BALB/c mice were infected with 1 x 106 lethal type Plasmodium yoelii 17XL in abdominal cavity, then the mice were treated with long-acting NO (NOC18) and short-acting NO ( N0C5 ) donors in vivo to cany out interference. Mature Plasmodium schizonts were purified and extracted their total RNA. The transcription levels of MSP-1, AMA-1, and RhopH complex were detected by real-time PCR relative quantitative determination. The results showed that the transcription levels of key molecules of MSP-1, AMA-1, and RhopH complex of Plasmodium invasion after treated with NOC5 decreased tangibly as compared with normal infected groups. However, the phenomenon was not seen in the groups treated with NOC18. These result indicated that NO inhibited the transcription levels of Plasmodium invasive key molecules, and proceeded to reduce the expression of Plasmodium corresponding protein, therefore, affected the Plasmodium invasive process.

  19. Import, Offshoring and Wages

    DEFF Research Database (Denmark)

    Fosse, Henrik Barslund; Maitra, Madhura

    exports - as positive exogenous shocks to the incentive to offshore to China. Both skill composition and rent sharing effects are found to be important in explaining the resultant gain in wages. We also show that the firm’s timing in the offshoring process determines the relative importance of a channel...... of skill composition and rent sharing available in typical firm level datasets - like ratio of educated to uneducated workers and sales per employee.......Offshoring firms are found to pay higher average wages than purely domestic firms. We provide a unifying empirical approach by capturing the different channels through which offshoring may explain this wage difference: (i) due to change in the composition of workers (skill composition effect) (ii...

  20. Surgical staging in endometrial cancer

    NARCIS (Netherlands)

    Mourits, MJ; Aalders, JG; Slager, E; Fauser, B; VanGeijn, H; Brolmann, H; Vervest, H

    2005-01-01

    Endometrial cancer is the most prevalent cancer of the female genital tract. No randomised study exists to prove that pelvic and para-aortic lymphadenectomy increases survival, either by dissecting micrometastases or by altering the adjuvant treatment in all early stage (stage I grade I and 2) endom

  1. Writing Stages: A Developmental Hierarchy.

    Science.gov (United States)

    Milner, Joseph O.

    The developmental stages of writing can be related to Jean Piaget's final three stages of development (preoperational, concrete operational, and formal operational) and to the narrative, descriptive, explanative, analytical, and artistic rhetorical modes. As the child enters kindergarten or the first grade, narrative blooms. By this age most young…

  2. Lernpunkt Deutsch--Stage 1.

    Science.gov (United States)

    Theil, Elvira

    1997-01-01

    Evaluates the first stage of "Lernpunkt Deutsch," a new three-stage German course designed for upper elementary and early secondary school. Describes the publisher's package of materials and the appropriateness of the course, utility of the different package elements, format of the materials, and assesses whether the course provides pedagogically…

  3. Lernpunkt Deutsch--Stage 1.

    Science.gov (United States)

    Theil, Elvira

    1997-01-01

    Evaluates the first stage of "Lernpunkt Deutsch," a new three-stage German course designed for upper elementary and early secondary school. Describes the publisher's package of materials and the appropriateness of the course, utility of the different package elements, format of the materials, and assesses whether the course provides pedagogically…

  4. Importance of Mangrove Ecosystem

    OpenAIRE

    Kathiresan, K.

    2012-01-01

    Mangrove forests are extremely important coastal resources, which are vital to our socio-economic development. Much of the ecological service of mangroves lies in protecting the coast from solar UV-B radiation, “green house” effects, and fury of cyclones, floods, sea level rise, wave action and coastal erosion. Mangroves contribute significantly to the global carbon cycle and produce large amounts of litter in the form of falling leaves, branches and other debris. Besides, mangrove habitats c...

  5. Imported Wines Widen Appeal

    Institute of Scientific and Technical Information of China (English)

    WAN LIXIN

    2006-01-01

    @@ "There are many factors contributing to the healthy growth of the wine market in China,"says Don St. Pierre, Jr., managing partner of ASC Fine Wines (Shanghai) Co Ltd, one of China's largest importers and distributors of fine wines. "The reduction in tariffs has helped - it has made wines more affordable. But also driving growth is the rise in Chinese people's incomes and their increasing interest in enjoying what is perceived as a socially and culturally sophisticated lifestyle."

  6. Calcium is important forus.

    Institute of Scientific and Technical Information of China (English)

    高利平

    2005-01-01

    Calcium is important for our health.We must have it in our diet to stay well.A good place to get it is from dairy products like milk, cheese and ice cream.One pound of cheese has fifty times the calcium we should have every day.Other foods have less.For example,a pound of beans also has calcium.But it has only three times the amount we ought to have daily.

  7. Discrepancy between clinicoradiological and surgicopathological staging in stage 1 carcinoma endometrium: Identification of risk factors

    Directory of Open Access Journals (Sweden)

    K Chitrathara

    2015-01-01

    Full Text Available INTRODUCTION: Carcinoma endometrium carries an excellent prognosis when diagnosed early. But controversies exist in the management of Ca endometrium confined to the uterus as to whether a complete surgical staging including lymph node dissection is needed always. This may increase unnecessary surgical morbidity for some. On the other hand, if not done it fails to recognize a subset of patients who require adjuvant treatment, thus affecting the outcome. Hence it is very important to categorize the patients to assess the need of complete surgical staging. AIM: The aim of the following study is to identify the risk factors influencing the upstaging of disease in clinicoradiologically stage 1 carcinoma endometrium. MATERIALS AND METHODS: A retrospective database evaluation of all cases of clinicoradiologically stage 1 carcinoma endometrium from January 2009 to September 2012. STATISTICAL ANALYSIS: Done using the statistical software SPSS − version 16 for windows (SPSS Inc. 233 South Wacker Drive, 11th Floor Chicago, IL 60606-6412 Independent samples test (t-test for equality of means were done and (two-tailed P < 0.05 − were significant. RESULTS: Carcinoma endometrium patients with grade 1, no or < 50% myometrial involvement, <2 cm size and no isthmus involvement had low risk of upstaging. CONCLUSION: Significant upstaging is seen in the present study with per-operative staging procedures. Until the standardization of magnetic resonance imaging (MRI techniques and reporting, or until a more sensitive non-invasive technique is devised, staging lymphadenectomy appears to be invaluable in risk assessment and prognosis.

  8. Multi-stage complex contagions

    Science.gov (United States)

    Melnik, Sergey; Ward, Jonathan A.; Gleeson, James P.; Porter, Mason A.

    2013-03-01

    The spread of ideas across a social network can be studied using complex contagion models, in which agents are activated by contact with multiple activated neighbors. The investigation of complex contagions can provide crucial insights into social influence and behavior-adoption cascades on networks. In this paper, we introduce a model of a multi-stage complex contagion on networks. Agents at different stages—which could, for example, represent differing levels of support for a social movement or differing levels of commitment to a certain product or idea—exert different amounts of influence on their neighbors. We demonstrate that the presence of even one additional stage introduces novel dynamical behavior, including interplay between multiple cascades, which cannot occur in single-stage contagion models. We find that cascades—and hence collective action—can be driven not only by high-stage influencers but also by low-stage influencers.

  9. PCR, exit stage left ...

    CERN Multimedia

    2004-01-01

    The Prevessin Control Room during LEP's start up in 1989. The Prévessin Control Room (PCR) was recently engulfed in a wave of nostalgia. The PCR, scene of some of the greatest moments in CERN's history, is being dismantled to prepare for a complete overhaul. In February 2006, a new combined control centre for all the accelerators will open its doors on the same site, together with a new building currently under construction (see Bulletin issue 27/2004 of 28 June 2004). This marks the end of an important chapter in CERN's history. The Prévessin Control Room saw its first momentous event 28 years ago when the 400 GeV beam for the SPS was commissioned in the presence of Project Leader John Adams. It was also here that the first proton-antiproton collisions were observed, in 1981. Eight years later, in 1989, operators and directors alike jumped for joy at the announcement of the first electron-positron collisions at the start up of LEP, the biggest accelerator in the world. Today the 80 terminals and PCs have b...

  10. Prognostic features of surgical stage I uterine carcinosarcoma.

    Science.gov (United States)

    Ferguson, Sarah E; Tornos, Carmen; Hummer, Amanda; Barakat, Richard R; Soslow, Robert A

    2007-11-01

    Uterine carcinosarcomas (CSs) are aggressive neoplasms, with 5-year overall survival (OS) rates of less than 35%. They are customarily separated into types harboring either heterologous or homologous mesenchymal elements, but the prognostic significance of this finding is controversial. Our goal was to study clinicopathologic features of possible prognostic relevance in surgical stage I uterine CS. A retrospective clinical and histopathologic review was performed for all women diagnosed with surgical stage I uterine CS. These tumors were compared with stage I high-grade endometrial (HGEm) carcinomas for clinical outcomes. There were 42 cases of surgical stage I uterine CS identified between January 1990 and January 2004. The disease-free survival and OS rates for patients with stage I CS were significantly worse compared with stage I HGEm (P=0.001; P=0.01). The median disease-free survival for patients with heterologous CS was 15 months and had not been reached for women with homologous CS (P=0.001). The 3-year OS rates were 45% versus 93% in women with heterologous compared with homologous stage I CS (P90%. Homologous stage I CSs have survival outcomes that are similar to HGEm. This further supports the concept that homologous stage I CSs are carcinomas with sarcomatoid features, not sarcomas. More importantly, the presence of heterologous sarcomatous elements is a powerful negative prognostic factor in surgical stage I uterine CS.

  11. GLOBALIZATION AND IMPORT RISKS

    Directory of Open Access Journals (Sweden)

    Popa Ioan

    2014-07-01

    Full Text Available Delocalization of production and diversification of the sources of offer in the global market place the issue of protection of consumer rights in major consumption centres, namely the European Union in a new light. A review of policies for the protection of consumer rights in the EU, USA and China, reveals major differences regarding the protection of consumer rights and the existence of gaps, and in particular the implementation of effective legislation in this regard. As such, the risks associated with imports have become a major concern in the European Union. The consumer has – one can say – a central role in the globalization process, which justifies the measures aimed at its protection. Although worldwide there are major differences in the degree of market regulation in matters of protection of consumer rights, the trend is the continuous adaptation of the offer to the requirements of global demand. However, one can still find significant gaps which translate into risks specific to the consumers in developed countries, namely in the EU. An important issue arises from this radical change of the localization of production centres in relation to the main consumption centres. While in the developed world, consumer rights protection has reached high levels both by creating an appropriate legislative framework and through consumer awareness and activism regarding their rights, in areas where much of the offer comes from the Western market (China, India, etc. modern mentality on the protection of consumer rights is just emerging. A major requirement is therefore the provision of a status of the consumer compatible with the benefits and risks of globalization, a status defined by safety and protection of imports. This paper confirms the thesis that, ultimately, the main factor counteracting the risks in matters of protection of consumer rights is the consumer, its awareness of its rights.

  12. Toxoplasmosis: An Important Protozoan Zoonosis

    Directory of Open Access Journals (Sweden)

    Sonar S. S. and Brahmbhatt M.N.

    Full Text Available Toxoplasmosis is an important infection caused by single celled parasite Toxoplasma gondii which is one of the world's most common parasites. Toxoplasmosis is considered to be the third leading cause of death attributed to food-borne illness in the United States. Most people affected never develop signs and symptoms. But for infants born to infected mothers and for people with compromised immune systems, toxoplasmosis can cause extremely serious complications. Toxoplasmosis was first described in 1908 from a small rodent. The parasite infects almost all worm blooded animals and serological evidence indicates that it is one of the most common of humans’ infections throughout the world. The disease is transmitted mainly by ingestion of infective stage of the parasite, organ transplant as well as blood transfusion in addition to the transplacental transmission which is very common. Toxoplasmosis can be presented in various forms of clinical manifestations depending on the immune status of the patient causing life threatening disease in AIDS patient. Pregnant women, cat owners, veterinarians, abattoir workers, children, cooks, butchers are considered as high risk group. Timely treatment of man and animals with proper antibiotic, hygienic measures, proper disinfection, mass education and vaccination are the measures to curtail the disease. [Veterinary World 2010; 3(9.000: 436-439

  13. Acting Antarctica: science on stage

    Science.gov (United States)

    Ciceri, Piera; Tizzoni, Paola; Pierro, Luigia

    2016-04-01

    Key-words: Polar science, Earth science, Theatre, Hands on activities The legendary Antarctic Expedition of sir E. Shackleton and his crew of 27 aboard the Endurance (1914/16) trapped in the Antarctic ice has become the starting point to learn about Polar Science and Climate Change. While the students were involved into this incredible adventure by the astonishing images of the Australian photographer Frank Hurley (who joined the crew), they discovered the world in which this story happened. Students were then involved in hands-on activities and role plays and have become the writers of the play "Uomini a scienza ai confini del mondo". They act the story of Shackelton's expedition and they tell at the same time to the audience about ice pack, ice cores and their role in understanding the past of the climate, physical and geographical characteristic of polar regions, thermal phenomena related to adaptations of polar animals, solar radiation at different latitude, day/night duration. The theater was the place to "stage" some scientific experiments and to explain the current research carried out in polar regions and their importance in climate change studies and to stress some similarities between Antarctica and space. The project was carried out from teachers of science, letters and geography and was born in collaboration with the "Piccolo Teatro di Milano" and the association "Science Under 18" with the support of a professional actor and director and was played for other schools at "EXPO 2015" in Milano (Italy). In our opinion drama activities improve reading comprehension, and both verbal and non-verbal communication skills. To be able to write and to act, students need a deep understanding of contents. Arts, including theatre, are a good key to involve emotionally students. To have an audience different from their own teachers and classmates offers a real task and the opportunity to play and let grow real skills.

  14. Ovarian chocolate cysts. Staging with relaxation time in MR imaging

    Energy Technology Data Exchange (ETDEWEB)

    Sugimura, Kazuro; Ishida, Tetsuya; Takemori, Masayuki; Kitagaki, Hajime; Tanaka, Yutaka; Yamasaki, Katsuhito; Shimizu, Tadafumi; Kono, Michio.

    1988-10-01

    Accurate preoperative staging of ovarian chocolate cysts is very important because recent hormonal therapy has been effective in low stage patients. However, it has been difficult to assess the preoperative stage of ovarian chocolate cysts. We evaluated the diagnostic potential of MRI in preoperative staging of 15 overian chocolate cysts. It was well known that the older the ovarian chocolate cyst was the more iron content it had. We examined the iron contents effect on T1 and T2 relaxation times in surgically confirmed chocolate cysts (stage II: 3 cases, stage III: 3 cases and stage IV: 9 cases by AFS classification, 1985) employing the 0.15-T MR system and 200 MHz spectrometer. There was a positive linear relation between T1 of the lesion using the MR system (T1) and T1 of the resected contents using the spectrometer (sp-T1); r = 0.93. The same relation was revealed between T2 and sp-T2; r = 0.87. It was indicated that T1 and T2 using the MR system was accurate. There was a negative linear relation between T1 and the iron contents ( r = -0.81) but no relation between T2 and the iron contents. T1 was 412 +- 91 msec for stage II, 356 +- 126 msec for stage III and 208 +- 30 msec for stage IV. T1 for stage IV was shorter than that for stage II and III, statistically significant differences were noted (p < 0.05). Thus, T1 was useful in differentiating a fresh from an old ovarian chocolate cyst. We concluded that T1 relaxation time using the MR system was useful for the staging of an ovarian chocolate cyst without surgery.

  15. Why is Astronomy Important?

    CERN Document Server

    Rosenberg, Marissa; Bladon, Georgia; Christensen, Lars Lindberg

    2013-01-01

    For a long time astronomers and other scientists believed that the importance of their work was evident to society. But in these difficult days of financial austerity, even the most obvious benefits of science have to undergo careful scrutiny. Eradicating poverty and hunger is a worldwide priority, and activities that do not directly attempt to resolve these issues can be hard to justify and support. However, several studies have told us that investing in science education, research and technology provides a great return (not only economically, but culturally and indirectly for the population in general and has helped countries to face and overcome crises. The scientific and technological development of a country or region is closely linked to its human development index) a statistic that is a measure of life expectancy, education and income.

  16. Most important human aluminoses

    Energy Technology Data Exchange (ETDEWEB)

    Avtsyn, A.P.

    1986-01-01

    Aluminoses are widespread forms of trace element deficiency of various severity. The organism is protected against a possible pathogenic influence of aluminum by a number of physiological mechanisms the most important among which is a regular urine excretion. A complex of pathological symptoms develops if serious homeostasis disturbances take place e. g. when renal deficiency or direct penetration of the trace element occur. The following forms of aluminosis should be distinguished: 1) simple accumulation in central nervous system which occurs in persons over 65 years; 2) aluminum accumulation in Alzheimer disease, in severe form of presenile and senile dementia; 3) dialysis aluminum encephalopathy; 4) non-dialysis infantile encephalopathy; 5) aluminum encephalopathy in total parenteral nutrition; 6) iatrogenic dialysis aluminum osteodystrophy; 7) jatrogenic peritoneal aluminosis; 8) aluminum pneumoconiosis of an occupational origin; 9) bronchospastic syndrome in aluminum smelter workers.

  17. Importance of binaural hearing.

    Science.gov (United States)

    Avan, Paul; Giraudet, Fabrice; Büki, Béla

    2015-01-01

    An essential task for the central auditory pathways is to parse the auditory messages sent by the two cochleae into auditory objects, the segregation and localisation of which constitute an important means of separating target signals from noise and competing sources. When hearing losses are too asymmetric, the patients face a situation in which the monaural exploitation of sound messages significantly lessens their performance compared to what it should be in a binaural situation. Rehabilitation procedures must aim at restoring as many binaural advantages as possible. These advantages encompass binaural redundancy, head shadow effect and binaural release from masking, the principles and requirements of which make up the topic of this short review. Notwithstanding the complete understanding of their neuronal mechanisms, empirical data show that binaural advantages can be restored even in situations in which faultless symmetry is inaccessible. © 2015 S. Karger AG, Basel.

  18. Import vs. Imitation?

    DEFF Research Database (Denmark)

    Kölcze, Zsófia

    2012-01-01

    of our analysis and interpretation more explicit.In archaeology there has been a tradition of distinguishing between original objects and imitations. However, this distinction does not provide us with much information about the social function and symbolic meaning of an object in a cultural context......In recent years archaeological research has developed a radically new theoretical approach to prehistoric material culture. Objects are no longer regarded as simple products of human behavior, but rather as agents interacting with people on multiple levels. As such, artifacts play an active role...... in producing, maintaining and reproducing social identities, communicating new ideas and technological innovations and creating ideologies and cosmologies. Our understanding of material culture has obtained a social dimension, and we as archaeologists have become aware of the importance of making this aspect...

  19. Stages of Salivary Gland Cancer

    Science.gov (United States)

    ... following stages are used for major salivary gland cancers: Enlarge Tumor sizes. The size of a tumor may be compared to the size of a pea (1 cm), peanut (2 cm), grape (3 cm), walnut (4 cm), lime (5 cm), ...

  20. CalCOFI Larvae Stages

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Developmental stages (yolk sac, preflexion, flexion, postflexion, or transformation) of selected fish larvae captured in CalCOFI icthyoplankton nets.

  1. Staged regenerative sorption heat pump

    Science.gov (United States)

    Jones, Jack A. (Inventor)

    1995-01-01

    A regenerative adsorbent heat pump process and system for cooling and heating a space. A sorbent is confined in a plurality of compressors of which at least four are first stage and at least four are second stage. The first stage operates over a first pressure region and the second stage over a second pressure region which is higher than the first. Sorbate from the first stage enters the second stage. The sorbate loop includes a condenser, expansion valve, evaporator and the compressors. A single sorbate loop can be employed for single-temperature-control such as air conditioning and heating. Two sorbate loops can be used for two-temperature-control as in a refrigerator and freezer. The evaporator temperatures control the freezer and refrigerator temperatures. Alternatively the refrigerator temperature can be cooled by the freezer with one sorbate loop. A heat transfer fluid is circulated in a closed loop which includes a radiator and the compressors. Low temperature heat is exhausted by the radiator. High temperature heat is added to the heat transfer fluid entering the compressors which are desorbing vapor. Heat is transferred from compressors which are sorbing vapor to the heat transfer fluid, and from the heat transfer fluid to the compressors which are desorbing vapor. Each compressor is subjected to the following phases, heating to its highest temperature, cooling down from its highest temperature, cooling to its lowest temperature, and warming up from its lowest temperature. The phases are repeated to complete a cycle and regenerate heat.

  2. Invasion dynamics of competing species with stage-structure.

    Science.gov (United States)

    Bewick, Sharon; Wang, Guoqing; Younes, Hannah; Li, Bingtuan; Fagan, William F

    2017-08-03

    The spread of an invasive species often results in a decline and subsequent disappearance of native competitors. Several models, primarily based on spatially explicit Lotka-Volterra competition dynamics, have been developed to understand this phenomenon. In general, the goal of these models is to relate fundamental life history traits, for example dispersal ability and competition strength, to the rate of spread of the invasive species, which is also the rate at which the invasive species displaces its native competitor. Stage-structure is often an important determinant of population dynamics, but it has received little attention within the context of Lotka-Volterra invasion models. For many species, behaviors like dispersal and competition depend on life-stage. To describe the processes of invasion in these species, it is important to understand how behaviors that vary as a function of life-stage can impact spread rate. In this paper, we develop a spatially explicit, stage-structured Lotka-Volterra competition model. By comparing spread speed predictions from this model to spread speed predictions from an analogous single-stage model, we are able to determine when stage-structure is important and how stage-dependent behavior can alter the characteristics of an invasion. Copyright © 2017. Published by Elsevier Ltd.

  3. Control of stage by stage changing linear dynamic systems

    Directory of Open Access Journals (Sweden)

    Barseghyan V.R.

    2012-01-01

    Full Text Available In this paper, the control problems of linear dynamic systems stage by stage changing and the optimal control with the criteria of quality set for the whole range of time intervals are considered. The necessary and sufficient conditions of total controllability are also stated. The constructive solving method of a control problem is offered, as well as the definitions of conditions for the existence of programmed control and motions. The explicit form of control action for a control problem is constructed. The method for solving optimal control problem is offered, and the solution of optimal control of a specific target is brought.

  4. 27 CFR 478.112 - Importation by a licensed importer.

    Science.gov (United States)

    2010-04-01

    ... importer. 478.112 Section 478.112 Alcohol, Tobacco Products, and Firearms BUREAU OF ALCOHOL, TOBACCO... Importation § 478.112 Importation by a licensed importer. (a) No firearm, firearm barrel, or ammunition shall be imported or brought into the United States by a licensed importer (as defined in § 478.11)...

  5. [Current MRI staging of rectal cancer].

    Science.gov (United States)

    Wietek, B M; Kratt, T

    2012-11-01

    Colorectal carcinoma is the second most prevalent cause for cancer, and has very variable outcomes. Advancements in surgery, the change from adjuvant to neo-adjuvant radio-chemo-therapies as well as in clinical diagnostics have improved the prognosis for patients in a multi-modal therapy concept. An accurate primary staging including a reliable prediction of the circumferential resection margin (CRM) has established MR Imaging (MRI) beside intraluminal endoscopic ultrasound (EUS). MRI facilitates the selection of patients likely to benefit from a preoperative therapy, especially in cases of unfavorable factors. Currently the relationship of the tumor to the mesorectal fascia has become a more important prognostic factor than the T-staging, particularly for surgical therapy. In addition further prognostic factors like the depth of infiltration into the perirectal fat and the extramural venous infiltration (EMVI) have important impact on therapy and prognosis. High resolution MRI has proved useful in clarifying the relationship between the tumor and the mesorectal fascia, which represents the CRM at the total mesorectal excision (TME) especially in the upper and middle third. Preoperative evaluation of the other prognostic factors as well as the nodal status is still difficult. It is used increasingly not only for primary staging but also progressively for the monitoring of neoadjuvant therapy. The addition of diffusion weighted imaging (DWI) is an interesting option for the improvement of response evaluation. The following overview provides an introduction of MRI diagnosis as well as its importance for the evaluation of the clinically relevant prognostic factors leading to an improvement of therapy and prognosis of patients with rectal carcinoma. © Georg Thieme Verlag KG Stuttgart · New York.

  6. Possibilities Of Opening Up the Stage-Gate Model

    Directory of Open Access Journals (Sweden)

    Biljana Stošić

    2014-12-01

    Full Text Available The paper presents basic elements of the Stage-Gate and Open innovation models, and possible connection of these two, resulting in what is frequently called an “Open Stage-Gate” model. This connection is based on opening up the new product development process and integration of the open innovation principles with the Stage-Gate concept, facilitating the import and export of information and technologies. Having in mind that the Stage Gate has originally been classified as the third generation model of innovation, the paper is dealing with the capabilities for applying the sixth generation Open innovation principles in today’s improved and much more flexible phases and gates of the Stage Gate. Lots of innovative companies are actually using both models in their NPD practice, looking for the most appropriate means of opening up the well-known closed innovation, especially in the domain of ideation through co-creation.

  7. Final Stages of Planet Formation

    Science.gov (United States)

    Goldreich, Peter; Lithwick, Yoram; Sari, Re'em

    2004-10-01

    gravitational interactions among them no longer produced large-scale chaos. After that their orbital eccentricities and inclinations were damped by dynamical friction from the remaining small bodies. The last and longest stage in planet formation was the cleanup of small bodies. Our understanding of this stage is fraught with uncertainty. The surviving protoplanets cleared wide gaps around their orbits that inhibited their ability to accrete small bodies. Nevertheless, in the inner planet system, all of the material in the small bodies ended up inside planets. Small bodies in the outer planet system probably could not have been accreted in the age of the solar system. A second generation of planetesimals may have formed in the disk of small bodies, by either collisional coagulation or gravitational instability. In the outer planet system, bodies of kilometer size or larger would have had their random velocities excited until their orbits crossed those of neighboring protoplanets. Ultimately they would have either escaped from the Sun or become residents of the Oort Cloud. An important distinction is that growth of the inner planets continued through cleanup, whereas assembly of the outer planets was essentially complete by the end of oligarchy. These conclusions imply that the surface density of the protoplanetary disk was that of the minimum solar mass nebula in the inner planet region but a few times larger in the outer planet region. The timescale through cleanup was set by the accretion rate at the geometrical cross section in the inner planet region and by the ejection rate at the gravitationally enhanced cross section in the outer planet region. It was a few hundred million years in the former and a few billion years in the latter. However, since Uranus and Neptune acquired most of their mass by the end of oligarchy, they may have formed before Earth! A few implications of the above scenario are worth noting. Impacts among protoplanets of comparable size were common in

  8. The role of MR imaging in staging femoral head osteonecrosis

    Energy Technology Data Exchange (ETDEWEB)

    Zibis, Aristidis H. [Department of Orthopaedic Surgery, Medical School, University of Thessaly, 22 Papakyriazi Street, Larissa 41222 (Greece); Karantanas, Apostolos H. [Department of Radiology, University Hospital of Heraklion, University of Crete Medical School, Heraklion, Crete 71110 (Greece); Roidis, Nikolaos T. [Department of Orthopaedic Surgery, Medical School, University of Thessaly, 22 Papakyriazi Street, Larissa 41222 (Greece); Hantes, Michael E. [Department of Orthopaedic Surgery, Medical School, University of Thessaly, 22 Papakyriazi Street, Larissa 41222 (Greece); Argiri, Paraskevi [CT-MRI Department, Larissa General Hospital, Larissa 41221 (Greece); Moraitis, Theofanis [Department of Orthopaedic Surgery, Medical School, University of Thessaly, 22 Papakyriazi Street, Larissa 41222 (Greece); Malizos, Konstantinos N. [Department of Orthopaedic Surgery, Medical School, University of Thessaly, 22 Papakyriazi Street, Larissa 41222 (Greece)]. E-mail: kmalizos@otenet.gr

    2007-07-15

    Reliability, accuracy and prognostic value of any classification system are important in evaluation and treatment of femoral head osteonecrosis. The purpose of the present study was to correlate the plain radiographs with MRI in femoral head osteonecrosis. Between 2000 and 2005, 115 hips (72 patients) were evaluated and classified according to the ARCO classification criteria with the use of plain radiographs and additional application of MRI. Classification was performed by consensus between a musculoskeletal radiologist and an orthopaedic surgeon. Sensitivity (SEN), specificity (SP), positive (PPV) and negative (NPV) predictive value of X-rays were estimated. According to MRI, 17 hips were classified as stage I, 25 as stage II, 48 as stage III and 25 as stage IV. The SEN, SP, PPV and NPV of plain radiographs were for stage II 88%, 90.5%, 78.6% and 95%; for stage III 79.2% 82%, 80.8% and 87.2%; for stage IV 76%, 100%, 100% and 90.9%, respectively. The agreement between plain radiographs and MRI was 80.6% for staging the disease, 71.2% for recording the location of the osteonecrotic lesion, 67.1% for evaluating the size of the lesion, 79.2% for the presence of collapse of the articular surface and 56.3% for the degree of collapse. In conclusion, the ARCO classification could miss important information in stages II and III, where treatment aims at preservation of the hip joint integrity. The results of the present study suggest that MRI should be incorporated in the classification of osteonecrosis (stages II and III), to add accuracy and prognostic value.

  9. Clinical prognostic markers in stage IIIC melanoma.

    Science.gov (United States)

    Madu, Max F; Schopman, Jaap H H; Berger, Danique M S; Klop, Willem M C; Jóźwiak, Katarzyna; Wouters, Michel W J M; van der Hage, Jos A; van Akkooi, Alexander C J

    2017-08-01

    Although the EORTC 18071-trial has shown a clear survival benefit for adjuvant ipilimumab, accurately selecting patients for this toxic adjuvant therapy is important. We aimed to identify prognostic factors for death and disease recurrence in AJCC stage IIIC melanoma patients. Retrospective analysis of patients who underwent lymph node dissection (LND) for stage IIIC melanoma in our institution between 2000 and 2016. Baseline characteristics, melanoma-specific survival (MSS), and disease-free survival (DFS) were assessed, and prognostic factors for recurrence and survival were analyzed using uni- and multivariable analysis. A total of 205 patients were included. Median follow-up was 20 months (interquartile range 11-43 months), median MSS was 28 months, and median DFS was 11 months. Five-year MSS was 33% and 5-year DFS was 23%. N3 (≥4 involved lymph nodes) and extracapsular extension (ECE) carried an increased risk of disease recurrence after LND and death by melanoma. Patients with both N3 and ECE had virtually no long-term survival. Although survival for patients with stage IIIC is poor in general, patients with both N3 disease and ECE constitute the group with the worst prognosis and should be considered for adjuvant therapy with ipilimumab or any other future effective adjuvant therapy (study). © 2017 Wiley Periodicals, Inc.

  10. Coaches' and referees' evaluation of the importance of the rules at the initiation stage of basketball

    Directory of Open Access Journals (Sweden)

    Celestina Vizca\\u00EDno

    2013-01-01

    Full Text Available Las reglas condicionan la práctica deportiva táctica y técnicamente. Por tanto, para que un jugador llegue a dominar el juego de baloncesto debe entender la lógica interna del mismo. En este estudio se trató de conocer la opinión tanto de los entrenadores como de los árbitros acerca de las reglas que se consideran más importantes a la hora de enseñar el baloncesto en la iniciación, así como analizar las diferencias entre ambos colectivos. La muestra del estudio estuvo formada por 37 entrenadores y 40 árbitros. Se utilizó un cuestionario para medir la opinión sobre el grado de importancia de la enseñanza de las reglas en la iniciación al baloncesto. El cuestionario estaba constituido por un total de 30 ítems, uno por cada regla, en los que se valoraba de 1 (Nada importante a 4 (Muy importante el grado de importancia a la hora de enseñarla. Se realizó un análisis descriptivo de los datos y para comprobar las diferencias entre las puntuaciones medias de los entrenadores y de los árbitros, se utilizó la prueba T de Student para muestras independientes. Los resultados mostraron que las reglas que deberían tener más importancia en la enseñanza del minibasket son: fuera de línea lateral y de fondo, agarrar/empujar, campo atrás, pasos y dobles. En la comparación entre la valoración de los entrenadores y los árbitros, se encontraron diferencias significativas en 11 de los 30 ítems por lo que se propone mayor coordinación entre ambos colectivos. Los entrenadores valoran más los pasos y dobles, seguramente por la repercusión en la enseñanza de la técnica, especialmente del jugador con balón. Los árbitros valoran más las reglas relacionadas con las faltas personales, probablemente para buscar el control del partido.

  11. New biostratigraphically important chitinozoans from the Kukruse Regional Stage, Upper Ordovician of Baltoscandia

    Directory of Open Access Journals (Sweden)

    Jaak Nõlvak

    2015-08-01

    Full Text Available Three new chitinozoan species, Conochitina savalaensis, Conochitina viruana and Belonechitina intonsa, are described. All these species are stratigraphically restricted to the Kukruse age (lowermost Sandbian, Laufeldochitina stentor chitinozoan Zone and have been recorded in numerous East Baltic sections as well as from NE Poland and NW Ukraine and Sweden. Their short temporal range and relative abundance point to a great biostratigraphical value for regional correlations near the base of the Upper Ordovician.

  12. Staging N0 oral cancer

    DEFF Research Database (Denmark)

    Thomsen, Jørn Bo; Sørensen, Jens Ahm; Grupe, Peter

    2005-01-01

    PURPOSE: To compare sentinel lymph node biopsy, magnetic resonance imaging (MRI), Doppler ultrasonography, and palpation as staging tools in patients with T1/T2 N0 cancer of the oral cavity. MATERIAL AND METHODS: Forty consecutive patients were enrolled (17 F and 23 M, aged 32-90 years), 24 T1......%, but the sensitivity of MRI 36% was low. The specificities were 100%, 85%, and 93%, respectively. By combined sentinel lymph node biopsy and ultrasonography the overall sensitivity could have been 100%. CONCLUSION: Sentinel lymph node biopsy improved staging of patients with small N0 oral cancers. Combined sentinel...

  13. Opening stages in triadic medical encounters in Taiwan.

    Science.gov (United States)

    Tsai, Mei-Hui

    2005-01-01

    Opening stages in medical interviews are important because good doctor-patient rapport facilitates the doctor's tasks in later stages, especially in triadic first-visit interviews where doctors are not acquaintances of patients and companions. Given its importance, the research examines opening stages in the Taiwanese context from two perspectives: discourse components of opening stages and discourse mechanisms of presenting non-acquaintances' identities, especially the companions' identities. By examining 30 geriatric triadic encounters collected in a teaching hospital in southern Taiwan, this research concludes that opening-stage interaction patterns in Taiwanese medical interviews differ from Western patterns in the following ways. Under time pressure, Taiwanese doctors tend to open the interview in a fast pattern that hardly allows verbal participation from the patients. The common practice of presenting non-acquaintances' identities in Western conversation openings is rarely observed in the Taiwanese context. As a result, contrary to the professional norms, most companions' identities are not clarified until they talk in the later stages, such as the pedigree stage, which is the most natural context for revealing their identities. This seeming violation of professional norms, however, can be explained by traditional Chinese interaction norms, and can be remedied by following another traditional norm-using a situational greeting. Further recommendations for Taiwanese medical professionals are also proposed to balance these potentially conflicting needs.

  14. Stages: A system for generating strategic alternaties for forest management.

    OpenAIRE

    Bos, J.

    1994-01-01

    Strategic planning is important in forest management. However, it has never been described clearly in literature. In this study a framework for strategic planning was developed and based on this a STrategic Alternatives Generating System (STAGES) to support decision making in strategic planning for forest management. This strategic planning consists of deciding on zoning, future forest and transition management. STAGES consists of a zoning model (which addresses the zoning decision problem th...

  15. The conundrum of parapsoriasis versus patch stage of mycosis fungoides

    OpenAIRE

    Sarveswari K; Yesudian Patrick

    2009-01-01

    Terminological confusion with benign dermatosis, such as parapsoriasis en plaques, makes it difficult to diagnose mycosis fungoides in the early patch stage. Early diagnosis of mycosis fungoides (MF) is important for deciding on type of therapy, prognosis and for further follow-up. However, until recently, there has been no consensus on criteria that would help in diagnosing the disease early. Some believe that large plaque parapsoriasis (LPP) should be classified with early patch stage of MF...

  16. How Are Lung Carcinoid Tumors Staged?

    Science.gov (United States)

    ... in How Are Lung Carcinoid Tumors Diagnosed? The TNM staging system A staging system is a standard ... cancer – the American Joint Committee on Cancer (AJCC) TNM staging system. The TNM system describes 3 key ...

  17. The Staging of the Turk

    DEFF Research Database (Denmark)

    Holm, Bent

    2013-01-01

    An analytical and contextualized presentation of the figure of the Turk on the Danish stage in the 18. century with a specific focus on the interaction between the actual commercial and military circumstances on the one hand and the performative representations on the other hand. How far did the ...

  18. Drama for Classroom and Stage.

    Science.gov (United States)

    Johnson, Albert and Bertha

    This book with a three-part format contains information which the would-be thespian needs to know for maximum enjoyment and success in stage activities. The first part, "Heritage," traces the history and development of the theater from primitive ritual through the drama of classical Greece and Rome, the Renaissance, and modern Europe and America,…

  19. When science takes centre stage

    CERN Multimedia

    2005-01-01

    The teachers at 'Science on stage' are not emotionally attached to their chalk. Neither are they are weary old men who sport tweed jackets with elbow-patches and enter into conversation with their blackboards. Actually, 'Science on stage' teachers are far from the cliché of the boring physics teacher who can only inspire yawns from his pupils. Some present the basic principles of mechanics using a bicycle, others explain chemistry with examples from everyday life. The most audacious of them go so far as to explain the Doppler effect by means of a play in which Einstein dreams about jumping cows... These are but a few of the activities and plays that will be shown during the EIROforum1 Science on Stage Festival (organised by 7 European scientific organisations including CERN), to be held from 21 to 25 November at CERN, Geneva. This festival is dedicated to the teaching science in order to make it more attractive. After the first edition 'Physics on Stage' which was held in 2000 at CERN, the laboratory agai...

  20. [Intraoperative staging of colorectal tumors].

    Science.gov (United States)

    Abdurakhmonov, Iu B; Mel'nikov, O R; Egorenkov, V V; Moiseenko, V M

    2007-01-01

    The effectiveness of intraoperative staging of tumor by sentinel node staining with lymphotropic dyes was evaluated in 60 patients with colorectal tumors (colon carcinoma -39, rectal cancer- 21). High sensitivity (84.6% and 87.5%, respectively) and specificity (100% and 100%, respectively) for regional lymph node assessment were identified for both colonic and rectal cancer.

  1. AND/OR Importance Sampling

    OpenAIRE

    Gogate, Vibhav; Dechter, Rina

    2012-01-01

    The paper introduces AND/OR importance sampling for probabilistic graphical models. In contrast to importance sampling, AND/OR importance sampling caches samples in the AND/OR space and then extracts a new sample mean from the stored samples. We prove that AND/OR importance sampling may have lower variance than importance sampling; thereby providing a theoretical justification for preferring it over importance sampling. Our empirical evaluation demonstrates that AND/OR importance sampling is ...

  2. Environment as the Stage for Economic Actors

    Institute of Scientific and Technical Information of China (English)

    John E Coulter; Shi Lei; Samantha Jenkins

    2007-01-01

    The relative importance of economics and environment in debate may soon be reversed due to the influence of three factors. Firstly, in the global economy it is hard to hide the unwanted products of economic processes. Secondly, huge advances in science will reduce the imperfect knowledge of markets, making some monitoring and analyzing tools show the design of sensible and equitable livelihood in communities, which is more important than the motivation of maximising profits for some individuals or fums. Thirdly, China, as the last major player on the planet to take on economic growth, comes from traditions fundamentally different from those economies that have experienced the Industrial Revolution previously. Its challenges with sustainability and environmental conservation predate Western economics by millennia,and it is implementing policies domestically and starting to work on the world stage that acknowledges that the surroundings are the host for any economic and socio-political system.

  3. The Research and Implementation of Three Stages Traffic Stations Intelligent Monitor Systems Based on GIS

    Science.gov (United States)

    Hong-ying, Chen; Ting, Xiao; WangTao; Jin-yi, He

    This system used three stage intelligent traffic station subsystems to forecast the path on which vehicle will go. First stage subsystem can forecast road node which adjacented to traffic station. Second stage subsystem was designed for bigger area, for example city, the third stage subsystem was for the larger area between city. Second stage subsystem system used A* based on orientation to calculate shortest path, third stage subsystem calculated critical node of a large area. The system can compose dispersed monitor information, forecast vehicle path, dynamic analysis, hierarchical monitor .It played an important role in ITS.

  4. Inverting the hourglass: quantitative evidence against the phylotypic stage in vertebrate development.

    OpenAIRE

    Olaf R. P. Bininda-Emonds; Jeffery, Jonathan E; Richardson, Michael K

    2003-01-01

    The concept of a phylotypic stage, when all vertebrate embryos show low phenotypic diversity, is an important cornerstone underlying modern developmental biology. Many theories involving patterns of development, developmental modules, mechanisms of development including developmental integration, and the action of natural selection on embryological stages have been proposed with reference to the phylotypic stage. However, the phylotypic stage has never been precisely defined, or conclusively ...

  5. Staging neurodegenerative disorders: structural, regional, biomarker, and functional progressions.

    Science.gov (United States)

    Archer, Trevor; Kostrzewa, Richard M; Beninger, Richard J; Palomo, Tomas

    2011-02-01

    The notion of staging in the neurodegenerative disorders is modulated by the constant and progressive loss of several aspects of brain structural integrity, circuitry, and neuronal processes. These destructive processes eventually remove individuals' abilities to perform at sufficient and necessary functional capacity at several levels of disease severity. The classification of (a) patients on the basis of diagnosis, risk prognosis, and intervention outcome, forms the basis of clinical staging, and (b) laboratory animals on the basis of animal model of brain disorder, extent of insult, and dysfunctional expression, provides the components for the clinical staging and preclinical staging, respectively, expressing associated epidemiological, biological, and genetic characteristics. The major focus of clinical staging in the present account stems from the fundamental notions of Braak staging as they describe the course and eventual prognosis for Alzheimer's disease, Lewy Body dementia, and Parkinson's disease. Mild cognitive impairment, which expresses the decline in episodic and semantic memory performance below the age-adjusted normal range without marked loss of global cognition or activities of daily living, and the applications of longitudinal magnetic resonance imaging, major instruments for the monitoring of either disease progression in dementia, present important challenges for staging concepts. Although Braak notions present the essential basis for further developments, current staging conceptualizations seem inadequate to comply with the massive influx of information dealing with neurodegenerative processes in brain, advanced both under clinical realities, and discoveries in the laboratory setting. The contributions of various biomarkers of disease progression, e.g., amyloid precursor protein, and neurotransmitter system imbalances, e.g., dopamine receptor supersensitivity and interactive propensities, await their incorporation into the existing staging

  6. Sleep stages, memory and learning.

    Science.gov (United States)

    Dotto, L

    1996-04-15

    Learning and memory can be impaired by sleep loss during specific vulnerable "windows" for several days after new tasks have been learned. Different types of tasks are differentially vulnerable to the loss of different stages of sleep. Memory required to perform cognitive procedural tasks is affected by the loss of rapid-eye-movement (REM) sleep on the first night after learning occurs and again on the third night after learning. REM-sleep deprivation on the second night after learning does not produce memory deficits. Declarative memory, which is used for the recall of specific facts, is not similarly affected by REM-sleep loss. The learning of procedural motor tasks, including those required in many sports, is impaired by the loss of stage 2 sleep, which occurs primarily in the early hours of the morning. These findings have implications for the academic and athletic performance of students and for anyone whose work involves ongoing learning and demands high standards of performance.

  7. Upper-Stage Flight Experiment

    Science.gov (United States)

    Anderson, W. E.; Boxwell, R.; Crockett, D. V.; Ross, R.; Lewis, T.; McNeal, C.; Verdarame, K.

    1999-01-01

    For propulsion applications that require that the propellants are storable for long periods, have a high density impulse, and are environmentally clean and non-toxic, the best choice is a combination of high-concentration hydrogen peroxide (High Test Peroxide, or HTP) and a liquid hydrocarbon (LHC) fuel. The HTP/LHC combination is suitable for low-cost launch vehicles, space taxi and space maneuvering vehicles, and kick stages. Orbital Sciences Corporation is under contract with the NASA Marshall Space Flight Center in cooperation with the Air Force Research Lab to design, develop and demonstrate a new low-cost liquid upper stage based on HTP and JP-8. The Upper Stage Flight Experiment (USFE) focuses on key technologies necessary to demonstrate the operation of an inherently simple propulsion system with an innovative, state-of-the-art structure. Two key low-cost vehicle elements will be demonstrated - a 10,000 lbf thrust engine and an integrated composite tank structure. The suborbital flight test of the USFE is scheduled for 2001. Preceding the flight tests are two major series of ground tests at NASA Stennis Space Center and a subscale tank development program to identify compatible composite materials and to verify their compatibility over long periods of time. The ground tests include a thrust chamber development test series and an integrated stage test. This paper summarizes the results from the first phase of the thrust chamber development tests and the results to date from the tank material compatibility tests. Engine and tank configurations that meet the goals of the program are described.

  8. Sleep stages, memory and learning.

    OpenAIRE

    Dotto, L

    1996-01-01

    Learning and memory can be impaired by sleep loss during specific vulnerable "windows" for several days after new tasks have been learned. Different types of tasks are differentially vulnerable to the loss of different stages of sleep. Memory required to perform cognitive procedural tasks is affected by the loss of rapid-eye-movement (REM) sleep on the first night after learning occurs and again on the third night after learning. REM-sleep deprivation on the second night after learning does n...

  9. Multi-stage flash degaser

    Science.gov (United States)

    Rapier, Pascal M.

    1982-01-01

    A multi-stage flash degaser (18) is incorporated in an energy conversion system (10) having a direct-contact, binary-fluid heat exchanger to remove essentially all of the noncondensable gases from geothermal brine ahead of the direct-contact binary-fluid heat exchanger (22) in order that the heat exchanger (22) and a turbine (48) and condenser (32) of the system (10) can operate at optimal efficiency.

  10. Patch stage of mycosis fungoides

    Directory of Open Access Journals (Sweden)

    Mavarkar Laxman

    2001-01-01

    Full Text Available Parapsoriasis is aeon troversial topic. There are many studies regarding the relationship of parapsoriasis to lymphoma but no correlation between histology and clinical appearance. Parapsoriasis satisfies histologic criteria for mycosis fungoides and therefore it should be considered as patch stage of mycosis fungoides. A 30-year-old man presented with scaly skin lesions over the trunk since 4 years. Routine blood and urine investigations were normal. Skin biopsy from the lesion revealed atypical lymphocytes within the epidermis without spongiosis.

  11. Screen for stage-specific expression genes between tail bud stage and heartbeat beginning stage in embryogenesis of gynogenetic silver crucian carp

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    A systemic study was initiated to identify stage-specific expression genes in fish embryogenesis by using suppression subtractive hybridization (SSH) technique. In this study, we presented a preliminary result on screen for stage-specific expression genes between tail bud stage (TBS) and heartbeat beginning stage (HBS) in gynogenetic silver crucian carp (Carassius auratus gibelio). Two SSH plasmid libraries specific for TBS embryos and HBS embryos were constructed, and stage-specific expression genes were screened between the two stages. 1963 TBS positive clones and 2466 HBS positive clones were sampled to PCR amplification, and 1373 TBS and 1809 HBS PCR positive clones were selected to carry out dot blots. 169TBS dot blot positive clones and 272 HBS dot blot positive clones were sequenced. Searching GenBank by using these nucleotide sequences indicated that most of the TBS dot blot positive clones could not be found homologous sequences in the database, while known genes were mainly detected from HBS dot blot positive clones. Of the 79 known genes, 20 were enzymes or kinases involved in important metabolism of embryonic development. Moreover, specific expressions of partial genes were further confirmed by virtual northern blots. This study is the first step for making a large attempt to study temporal and spatial control f gene expression in the gynogenetic fish embryogenesis.

  12. Staging of carcinoma of the uterine cervix and endometrium

    Energy Technology Data Exchange (ETDEWEB)

    Koyama, Takashi; Tamai, Ken; Togashi, Kaori [Kyoto University, Department of Diagnostic Radiology, Graduate School of Medicine, Kyoto (Japan)

    2007-08-15

    Carcinoma of the uterine cervix and endometrium are common gynecologic malignancies. Both carcinomas are staged and managed by means of the International Federation of Gynecology and Obstetrics (FIGO) staging system. In uterine cervical cancer, the FIGO staging system is determined preoperatively by limited conventional procedures. Although this system is effective for early stage disease, it has inherent inaccuracies in advanced stage diseases and does not address nodal involvement. CT and MR imaging are widely used as comprehensive imaging modalities to evaluate tumor size and extent, and nodal involvement. MR imaging is an excellent modality for depicting invasive cervical carcinoma and can provide objective measurement of tumor volume, and provides high negative predictive value for parametrial invasion and stage IVA disease. In contrast, endometrial cancer is surgically staged. Beside recognition of the important prognostic factors, including histologic subtype and grade, accurate assessment of the tumor extent on preoperative MR imaging is expected to greatly optimize surgical procedure and therapeutic strategy. Contrast-enhanced MR imaging can offer ''one stop'' examination for evaluating the depth of myometrial invasion cervical invasion and nodal metastases. Evaluation of myometrial invasion on MR imaging may be an alternative to gross inspection of the uterus during the surgery. (orig.)

  13. 75 FR 9019 - Notice of Receipt of Petition for Decision That Nonconforming 2009 AL Spaw EMA Mobile Stage...

    Science.gov (United States)

    2010-02-26

    ... Nonconforming 2009 AL Spaw EMA Mobile Stage Trailers Are Eligible for Importation AGENCY: National Highway... 2009 AL Spaw EMA Mobile Stage trailers are eligible for importation. SUMMARY: This document announces... 2009 AL Spaw EMA Mobile Stage trailers that were not originally manufactured to comply with...

  14. The Three Stages of Teaching Reading

    Institute of Scientific and Technical Information of China (English)

    郝禹

    2005-01-01

    If we want to improve our way of teaching, one way is to teach reading in three stages: Pre- reading stage, while-reading stage, and post- reading stage. Each stage has a different goal and deals with different reading strategies. Prereading means before the text is read. In while reading stage, we have looked at the main reading skills: skimming, scanning , reading for detail , drawing inferences about the author's purpose and intention. Post - reading stage mainly focuses on the exploitation of the text. It aims to help the reader understand the content and structure of the text, as well as the author's purpose in writing it.

  15. Frontostriatal Cognitive Staging in Parkinson's Disease

    Directory of Open Access Journals (Sweden)

    Raúl de la Fuente-Fernández

    2012-01-01

    Full Text Available Cognitive impairment and behavioural disorders are often encountered in subjects with Parkinson's disease (PD. A simple PD-related frontostriatal cognitive dysfunction (PDFCD staging is proposed. Executive dysfunction and mental fatigue (stage I, depression/anxiety (stage IIa, apathy/pain (stage IIb, and dementia (stage III reflect a sequential process of dopamine depletion occurring in different regions of the striatum (stages I and II and the frontal cortex (stage III. In addition to these nonmotor manifestations present in the unmedicated (OFF state, the PDFCD model also predicts a number of complications related to dopaminergic treatment (ON state, from impulse control disorders (stages I and IIa to hallucinations (stage IIb and psychosis (stage III. Although the model admittedly needs further refinements, it provides a framework for hypothesis testing and may help clinicians optimize therapeutic strategies.

  16. An Exploration of Inexpensive, Automated Methods for Measuring River Stage

    Science.gov (United States)

    Kruger, A.; Niemeier, J. J.; Krajewski, W. F.; Ceynar, D.; Wagner, G. D.

    2009-12-01

    River stage measurements are of fundamental importance in many hydrologic and environmental applications. Even though the U.S. Geological Survey (USGS) operates a large network of stream gauging stations on larger rivers, river stage is unavailable in many locations, especially on smaller rivers and streams. We have been exploring a variety of relatively inexpensive techniques for automated river stage measurements, targeting medium and smaller rivers. These techniques include ultrasonic water-surface height measurement, submerged pressure transducers that incorporate a unique bladder system, and a new radio-based technique. The latter method uses inexpensive radios that operate in the unlicensed industrial, scientific, and medical (ISM) band, and uses the phase delay of radio waves from a submerged radio to infer river stage. The technique holds promise as an inexpensive/disposable sensor that can find application in rapid-response settings such as flooding. In this work, we present and discuss the instruments along with comparisons of the different methods.

  17. Pengaruh Self-Acceptance Importance, Affiliation Importance, dan Community Feeling Importance terhadap Compulsive Buying

    Directory of Open Access Journals (Sweden)

    Euis Soliha

    2011-03-01

    Full Text Available This study focused on phenomenon behavior of compulsive buying. The study examined how Self-Acceptance Importance, Affiliation Importance, and Community Feeling Importance influenced on Compulsive Buying. Population in this research was students in Kota Semarang, and 104 students become samples. To answer problem that is accurate, researcher applies econometrics Logit model. Result of research indicates that there were negativity influence Self-Acceptance Importance, Affiliation Importance and Community Feeling to Compulsive Buying. Result of this supports all hypothesis and consistent with theory.Keywords:    compulsive buying, self-acceptance Importance, affiliation Importance, community feeling Importance, Logit Model

  18. How important is importance for prospective memory? A review

    Directory of Open Access Journals (Sweden)

    Stefan eWalter

    2014-06-01

    Full Text Available Forgetting to carry out an intention as planned can have serious consequences in everyday life. People sometimes even forget intentions that they consider as very important. Here, we review the literature on the impact of importance on prospective memory performance. We highlight different methods used to manipulate the importance of a prospective memory task such as providing rewards, importance relative to other ongoing activities, absolute importance, and providing social motives. Moreover, we address the relationship between importance and other factors known to affect prospective memory and ongoing task performance such as type of prospective memory task (time-, event- or activity-based, cognitive loads, and cue focality. Finally, we provide a connection to motivation, we summarize the effects of task importance and we identify important venues for future research.

  19. Import Security: Assessing the Risks of Imported Food.

    Science.gov (United States)

    Welburn, Jonathan; Bier, Vicki; Hoerning, Steven

    2016-11-01

    We use data on food import violations from the FDA Operational and Administrative System for Import Support (OASIS) to address rising concerns associated with imported food, quantify import risks by product and by country of origin, and explore the usefulness of OASIS data for risk assessment. In particular, we assess whether there are significant trends in violations, whether import violations can be used to quantify risks by country and by product, and how import risks depend on economic factors of the country of origin. The results show that normalizing import violations by volume of imports provides a meaningful indicator of risk. We then use regression analysis to characterize import risks.  Using this model, we analyze import risks by product type, violation type, and economic factors of the country of origin.  We find that OASIS data are useful in quantifying food import risks, and that the rate of refusals provides a useful decision tool for risk management.  Furthermore, we find that some economic factors are significant indicators of food import risk by country. © 2016 Society for Risk Analysis.

  20. Using the life history model to set the stage(s) of growth and senescence in bioarchaeology and paleodemography.

    Science.gov (United States)

    Roksandic, Mirjana; Armstrong, Stephanie D

    2011-07-01

    Paleodemography, the study of demographic parameters of past human populations, relies on assumptions including biological uniformitarianism, stationary populations, and the ability to determine point age estimates from skeletal material. These assumptions have been widely criticized in the literature and various solutions have been proposed. The majority of these solutions rely on statistical modeling, and have not seen widespread application. Most bioarchaeologists recognize that our ability to assess chronological age is inherently limited, and have instead resorted to large, qualitative, age categories. However, there has been little attempt in the literature to systematize and define the stages of development and ageing used in bioarchaeology. We propose that stages should be based in the human life history pattern, and their skeletal markers should have easily defined and clear endpoints. In addition to a standard five-stage developmental model based on the human life history pattern, current among human biologists, we suggest divisions within the adult stage that recognize the specific nature of skeletal samples. We therefore propose the following eight stages recognizable in human skeletal development and senescence: infancy, early childhood, late childhood, adolescence, young adulthood, full adulthood, mature adulthood, and senile adulthood. Striving toward a better prediction of chronological ages will remain important and could eventually help us understand to what extent past societies differed in the timing of these life stages. Furthermore, paleodemographers should try to develop methods that rely on the type of age information accessible from the skeletal material, which uses life stages, rather than point age estimates.

  1. Revised National Pressure Ulcer Advisory Panel Pressure Injury Staging System

    Science.gov (United States)

    Black, Joyce M.; Goldberg, Margaret; McNichol, Laurie; Moore, Lynn; Sieggreen, Mary

    2016-01-01

    Our understanding of pressure injury etiology and development has grown in recent years through research, clinical expertise, and global interdisciplinary expert collaboration. Therefore, the National Pressure Ulcer Advisory Panel (NPUAP) has revised the definition and stages of pressure injury. The revision was undertaken to incorporate the current understanding of the etiology of pressure injuries, as well as to clarify the anatomical features present or absent in each stage of injury. An NPUAP-appointed Task Force reviewed the literature and created drafts of definitions, which were then reviewed by stakeholders and the public, including clinicians, educators, and researchers around the world. Using a consensus-building methodology, these revised definitions were the focus of a multidisciplinary consensus conference held in April 2016. As a result of stakeholder and public input, along with the consensus conference, important changes were made and incorporated into the new staging definitions. The revised staging system uses the term injury instead of ulcer and denotes stages using Arabic numerals rather than Roman numerals. The revised definition of a pressure injury now describes the injuries as usually occurring over a bony prominence or under a medical or other device. The revised definition of a Stage 2 pressure injury seeks to clarify the difference between moisture-associated skin damage and injury caused by pressure and/or shear. The term suspected has been removed from the Deep Tissue Pressure Injury diagnostic label. Each definition now describes the extent of tissue loss present and the anatomical features that may or may not be present in the stage of injury. These important revisions reflect the methodical and collaborative approach used to examine the available evidence and incorporate current interdisciplinary clinical expertise into better defining the important phenomenon of pressure injury etiology and development. PMID:27749790

  2. Single conversion stage amplifier - SICAM

    Energy Technology Data Exchange (ETDEWEB)

    Ljusev, P.

    2005-12-15

    This Ph.D. thesis presents a thorough analysis of the so called SICAM - SIngle Converter stage AMplifier approach to building direct energy conversion audio power amplifiers. The mainstream approach for building isolated audio power amplifiers today consists of isolated DC power supply and Class D amplifier, which essentially represents a two stage solution, where each of the components can be viewed as separate and independent part. The proposed SICAM solution strives for direct energy conversion from the mains to the audio output, by dedicating the operation of the components one to another and integrating their functions, so that the final audio power amplifier represents a single-stage topology with higher efficiency, lower volume, less board space, lower component count and subsequently lower cost. The SICAM approach is both applicable to non-isolated and isolated audio power amplifiers, but the problems encountered in these two cases are different. Non-isolated SICAM solutions are intended for both AC mains-connected and battery-powered devices. In non-isolated mains-connected SICAMs the main idea is to simplify the power supply or even provide integrated power factor correction (PFC) functions, while still maintaining low component stress and good audio performance by generally decreasing the input voltage level to the Class D audio power amplifier. On the other hand, non-isolated battery-powered SICAMs have to cope with the ever changing battery voltage and provide output voltage levels which are both lower and higher than the battery voltage, while still being simple and single-stage energy conversion solutions. In isolated SICAMs the isolation transformer adjusts the voltage level on the secondary side to the desired level, so the main challenges here are decreasing the size of the magnetic core and reducing the number and size of bulky reactive components as much as possible. The main focus of this thesis is directed towards the isolated SICAMs and

  3. Development and Applications of a Stage Stacking Procedure

    Science.gov (United States)

    Kulkarni, Sameer; Celestina, Mark L.; Adamczyk, John J.

    2012-01-01

    The preliminary design of multistage axial compressors in gas turbine engines is typically accomplished with mean-line methods. These methods, which rely on empirical correlations, estimate compressor performance well near the design point, but may become less reliable off-design. For land-based applications of gas turbine engines, off-design performance estimates are becoming increasingly important, as turbine plant operators desire peaking or load-following capabilities and hot-day operability. The current work develops a one-dimensional stage stacking procedure, including a newly defined blockage term, which is used to estimate the off-design performance and operability range of a 13-stage axial compressor used in a power generating gas turbine engine. The new blockage term is defined to give mathematical closure on static pressure, and values of blockage are shown to collapse to curves as a function of stage inlet flow coefficient and corrected shaft speed. In addition to these blockage curves, the stage stacking procedure utilizes stage characteristics of ideal work coefficient and adiabatic efficiency. These curves are constructed using flow information extracted from computational fluid dynamics (CFD) simulations of groups of stages within the compressor. Performance estimates resulting from the stage stacking procedure are shown to match the results of CFD simulations of the entire compressor to within 1.6% in overall total pressure ratio and within 0.3 points in overall adiabatic efficiency. Utility of the stage stacking procedure is demonstrated by estimation of the minimum corrected speed which allows stable operation of the compressor. Further utility of the stage stacking procedure is demonstrated with a bleed sensitivity study, which estimates a bleed schedule to expand the compressors operating range.

  4. On Two-stage Seamless Adaptive Design in Clinical Trials

    Directory of Open Access Journals (Sweden)

    Shein-Chung Chow

    2008-12-01

    Full Text Available In recent years, the use of adaptive design methods in clinical research and development based on accrued data has become very popular because of its efficiency and flexibility in modifying trial and/or statistical procedures of ongoing clinical trials. One of the most commonly considered adaptive designs is probably a two-stage seamless adaptive trial design that combines two separate studies into one single study. In many cases, study endpoints considered in a two-stage seamless adaptive design may be similar but different (e.g. a biomarker versus a regular clinical endpoint or the same study endpoint with different treatment durations. In this case, it is important to determine how the data collected from both stages should be combined for the final analysis. It is also of interest to know how the sample size calculation/allocation should be done for achieving the study objectives originally set for the two stages (separate studies. In this article, formulas for sample size calculation/allocation are derived for cases in which the study endpoints are continuous, discrete (e.g. binary responses, and contain time-to-event data assuming that there is a well-established relationship between the study endpoints at different stages, and that the study objectives at different stages are the same. In cases in which the study objectives at different stages are different (e.g. dose finding at the first stage and efficacy confirmation at the second stage and when there is a shift in patient population caused by protocol amendments, the derived test statistics and formulas for sample size calculation and allocation are necessarily modified for controlling the overall type I error at the prespecified level.

  5. Problem solving stages in the five square problem.

    Science.gov (United States)

    Fedor, Anna; Szathmáry, Eörs; Öllinger, Michael

    2015-01-01

    According to the restructuring hypothesis, insight problem solving typically progresses through consecutive stages of search, impasse, insight, and search again for someone, who solves the task. The order of these stages was determined through self-reports of problem solvers and has never been verified behaviorally. We asked whether individual analysis of problem solving attempts of participants revealed the same order of problem solving stages as defined by the theory and whether their subjective feelings corresponded to the problem solving stages they were in. Our participants tried to solve the Five-Square problem in an online task, while we recorded the time and trajectory of their stick movements. After the task they were asked about their feelings related to insight and some of them also had the possibility of reporting impasse while working on the task. We found that the majority of participants did not follow the classic four-stage model of insight, but had more complex sequences of problem solving stages, with search and impasse recurring several times. This means that the classic four-stage model is not sufficient to describe variability on the individual level. We revised the classic model and we provide a new model that can generate all sequences found. Solvers reported insight more often than non-solvers and non-solvers reported impasse more often than solvers, as expected; but participants did not report impasse more often during behaviorally defined impasse stages than during other stages. This shows that impasse reports might be unreliable indicators of impasse. Our study highlights the importance of individual analysis of problem solving behavior to verify insight theory.

  6. Preoperative staging of rectal cancer.

    Science.gov (United States)

    Smith, Neil; Brown, Gina

    2008-01-01

    Detailed preoperative staging using high resolution magnetic resonance imaging (MRI) enables the selection of patients that require preoperative therapy for tumour regression. This information can be used to instigate neoadjuvant therapy in those patients with poor prognostic features prior to disturbing the tumour bed and potentially disseminating disease. The design of trials incorporating MR assessment of prognostic factors prior to therapy has been found to be of value in assessing treatment modalities and outcomes that are targeted to these preoperative prognostic subgroups and in providing a quantifiable assessment of the efficacy of particular chemoradiation treatment protocols by comparing pre-treatment MR staging with post therapy histology assessment. At present, we are focused on achieving clear surgical margins of excision (CRM) to avoid local recurrence. We recommend that all patients with rectal cancer should undergo pre-operative MRI staging. Of these, about half will have good prognosis features (T1-T3b, N0, EMVI negative, CRM clear) and may safely undergo primary total mesorectal excision. Of the remainder, those with threatened or involved margins will certainly benefit from pre-operative chemoradiotherapy with the aim of downstaging to permit safe surgical excision. In the future, our ability to recognise features predicting distant failure, such as extramural vascular invasion (EMVI) may be used to stratify patients for neo-adjuvant systemic chemotherapy in an effort to prevent distant relapse. The optimal pre-operative treatment regimes for these patients (radiotherapy alone, systemic chemotherapy alone or combination chemo-radiotherapy) is the subject of current and future trials.

  7. Small Stage,big Charm

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    In a world where bigger is often seen as better, entertainment, especially the world of theater, has gone full circle and returned to smaller, more cozy productions that allow both the directors and the audience more freedom of interpretation and expression. Established in 1953, the Beijing People’s Art Theater on the northern end of Wangfujing Street, Beijing’s most popular pedestrian-only commercial street, has a colorful past, cataloguing a stream of trends, thoughts and ideas on stage for 55 years. In 1995, a new concept in theater was introduced in. The former canteen of the Beijing People’s Art Theater was changed into a smaller theater.

  8. Morphogenesis of early stage melanoma

    Science.gov (United States)

    Chatelain, Clément; Amar, Martine Ben

    2015-08-01

    Melanoma early detection is possible by simple skin examination and can insure a high survival probability when successful. However it requires efficient methods for identifying malignant lesions from common moles. This paper provides an overview first of the biological and physical mechanisms controlling melanoma early evolution, and then of the clinical tools available today for detecting melanoma in vivo at an early stage. It highlights the lack of diagnosis methods rationally linking macroscopic observables to the microscopic properties of the tissue, which define the malignancy of the tumor. The possible inputs of multiscale models for improving these methods are shortly discussed.

  9. [Initial stages of steel biocorrosion].

    Science.gov (United States)

    Zhigletsova, S K; Rodin, V B; Kobelev, V S; Aleksandrova, N V; Rasulova, G E; Kholodenko, V P

    2000-01-01

    Initial stages of corrosion of mild steel induced by Klebsiela rhinoscleromatis BO2 were studied in various media. The effect of the microorganism was detected 8-10 h after inoculation. The number of viable cells were virtually unchanged within one month in all media, but the corrosive activity of the strain decreased. The corrosive activity of microorganisms can be determined by spectrophotometry even only after incubation for 24 h. At a low level of organic substrate, even strong colonization with microorganisms does not inevitably result in a significant damage to metals.

  10. Coexistence of competing stage-structured populations.

    KAUST Repository

    Fujiwara, Masami

    2011-10-05

    This paper analyzes the stability of a coexistence equilibrium point of a model for competition between two stage-structured populations. In this model, for each population, competition for resources may affect any one of the following population parameters: reproduction, juvenile survival, maturation rate, or adult survival. The results show that the competitive strength of a population is affected by (1) the ratio of the population parameter influenced by competition under no resource limitation (maximum compensatory capacity) over the same parameter under a resource limitation due to competition (equilibrium rate) and (2) the ratio of interspecific competition over intraspecific competition; this ratio was previously shown to depend on resource-use overlap. The former ratio, which we define as fitness, can be equalized by adjusting organisms\\' life history strategies, thereby promoting coexistence. We conclude that in addition to niche differentiation among populations, the life history strategies of organisms play an important role in coexistence.

  11. "End-stage" pulmonary fibrosis in sarcoidosis.

    Science.gov (United States)

    Teirstein, Alvin T; Morgenthau, Adam S

    2009-02-01

    Pulmonary fibrosis is an unusual "end stage" in patients with sarcoidosis. Fibrosis occurs in a minority of patients, and presents with a unique physiologic combination of airways dysfunction (obstruction) superimposed on the more common restrictive dysfunction. Imagin techniques are essential to the diagnosis, assessment and treatment of pulmonary fibrosis. Standard chest radiographs and CT scans may reveal streaks, bullae, cephalad retraction of the hilar areas, deviation of the trachea and tented diaphragm. Positive gallium and PET scans indicate residual reversible granulomatous disease and are important guides to therapy decisions. Treatment, usually with corticosteroids, is effective in those patients with positive scans, but fibrosis does not improve with any treatment. With severe functional impariment and patient disability, pulmonary hypertension and right heart failure may supervene for which the patient will require treatment. Oxygen, careful diuresis, sildenafil and bosentan may be salutary. These patients are candidates for lung transplantation.

  12. Autobiographic Performance. Intimacy as a Stage Practice

    Directory of Open Access Journals (Sweden)

    Josefina Alcázar

    2015-11-01

    Full Text Available This essay analyses performance as an expression of the age of intimacy, an age we are currently living through, where self-representation takes on a multiplicity and heterogeneity of registers and strategies. In autobiographic performance the boundary between the public and the private becomes blurred, which is expressive of the transformation of contemporary subjectivity, a search of the experience of living, and an urge to publicise intimacy. It is based on everyday life, the smaller things, not the important issues but the occurrence of the usual as it happens day by day. Performance, or action art, is an art of the self which is framed within this context of revealing one’s intimacy; and this is what makes it akin to several forms of searching for identity and self-knowledge, in which artists put their own subjectivity up on the stage.

  13. A simplified staging system based on the radiological findings in different stages of ochronotic spondyloarthropathy

    Directory of Open Access Journals (Sweden)

    Isaac Jebaraj

    2013-01-01

    Full Text Available This study describes a group of 26 patients with ochronotic spondyloarthropathy who were on regular treatment and follow-up at a tertiary level hospital and proposes a simplified staging system for ochronotic spondyloarthropathy based on radiographic findings seen in the thoracolumbar spine. This proposed classification makes it easy to identify the stage of the disease and start the appropriate management at an early stage. Four progressive stages are described: an inflammatory stage (stage 1, the stage of early discal calcification (stage 2, the stage of fibrous ankylosis (stage 3, and the stage of bony ankylosis (stage 4. To our knowledge, this is the largest reported series of radiological description of spinal ochronosis, and emphasizes the contribution of the spine radiograph in the diagnosis and staging of the disease.

  14. Turbine Stages with Heat Transfer

    Directory of Open Access Journals (Sweden)

    E. Y. K. Ng

    1998-01-01

    Full Text Available A better understanding of the flow inside the multi-stage turbomachines will be very useful to both the designer and operator. The numerical calculation for single blade row has been well established with the time marching computation of the Navier-Stokes equations. But there will exist much more difficulties for the multi-blade rows due to the rotor-stator interaction. The major problems are related to the unsteady flow which will inevitably exist in the blade passages due to the different rotating speed and possible the different in blade number. A method is presented for simulating various turbine blade rows in single-stage environment. A solver has been developed for studying the complex flow analysis of ‘proposed high pressure turbine’ (HPT using quasi-3-D Reynolds-averaged Navier-Stokes (Q3D RNS equations. The code achieves good quality solutions quickly even with relatively coarse mesh sizes. The work is first validated both with UTRC's and Zeschky and Gallus' subsonic turbine test cases covering inlet boundary conditions and Reynolds-averaged values. A H-type grid is adopted as it is easy to generate and can readily extend to 3D application. When rows are closely spaced, there can be a strong interaction which will impact the aerodynamic, thermal and structural performance of the blade.

  15. Metabolomics Identifies Multiple Candidate Biomarkers to Diagnose and Stage Human African Trypanosomiasis

    Science.gov (United States)

    Vincent, Isabel M.; Daly, Rónán; Courtioux, Bertrand; Cattanach, Amy M.; Biéler, Sylvain; Ndung’u, Joseph M.; Bisser, Sylvie; Barrett, Michael P.

    2016-01-01

    Treatment for human African trypanosomiasis is dependent on the species of trypanosome causing the disease and the stage of the disease (stage 1 defined by parasites being present in blood and lymphatics whilst for stage 2, parasites are found beyond the blood-brain barrier in the cerebrospinal fluid (CSF)). Currently, staging relies upon detecting the very low number of parasites or elevated white blood cell numbers in CSF. Improved staging is desirable, as is the elimination of the need for lumbar puncture. Here we use metabolomics to probe samples of CSF, plasma and urine from 40 Angolan patients infected with Trypanosoma brucei gambiense, at different disease stages. Urine samples provided no robust markers indicative of infection or stage of infection due to inherent variability in urine concentrations. Biomarkers in CSF were able to distinguish patients at stage 1 or advanced stage 2 with absolute specificity. Eleven metabolites clearly distinguished the stage in most patients and two of these (neopterin and 5-hydroxytryptophan) showed 100% specificity and sensitivity between our stage 1 and advanced stage 2 samples. Neopterin is an inflammatory biomarker previously shown in CSF of stage 2 but not stage 1 patients. 5-hydroxytryptophan is an important metabolite in the serotonin synthetic pathway, the key pathway in determining somnolence, thus offering a possible link to the eponymous symptoms of “sleeping sickness”. Plasma also yielded several biomarkers clearly indicative of the presence (87% sensitivity and 95% specificity) and stage of disease (92% sensitivity and 81% specificity). A logistic regression model including these metabolites showed clear separation of patients being either at stage 1 or advanced stage 2 or indeed diseased (both stages) versus control. PMID:27941966

  16. An Analysis of Kohlberg's "Stage 4 1/2" within an Enhanced Framework of Moral Stages.

    Science.gov (United States)

    Minnameier, Gerhard

    This paper discusses a well-known problem of stage categorization within Kohlberg's theory of moral stages (L. Kohlberg, 1973), that of "Stage 4 1/2." Some subjects previously scored at stage 4 in Kohlberg's framework took on some characteristics of stage 2 reasoning, which suggested the possibility of regression. To reconcile this…

  17. Stages: A system for generating strategic alternaties for forest management.

    NARCIS (Netherlands)

    Bos, J.

    1994-01-01

    Strategic planning is important in forest management. However, it has never been described clearly in literature. In this study a framework for strategic planning was developed and based on this a STrategic Alternatives Generating System (STAGES) to support decision making in strategic planning for

  18. [Theories of stages of life within the anthropology of romanticism].

    Science.gov (United States)

    Schweizer, Pia-Johanna; Schweizer, Stefan

    2006-12-01

    The essay discusses the importance and prominence of theories about different stages of life in the anthropological and medical discourse of romanticism. This discourse has clearly a stabilising and restaurative function, favouring the age of moderate manhood. The political and social regulative implications of these theories demand a restaurative roll-back. The essay is based on a concept of sociology of knowledge formation.

  19. The IASLC/ITMIG Thymic Epithelial Tumors Staging Project

    DEFF Research Database (Denmark)

    Kondo, Kazuya; Van Schil, Paul; Detterbeck, Frank C

    2014-01-01

    Stage classification is an important underpinning of management of patients with cancer, and rests on a combination of three components: T for tumor extent, N for nodal involvement, and M for more distant metastases. This article details an initiative to develop proposals for the first official...

  20. STAGES : a system for generating strategic alternatives for forest management

    NARCIS (Netherlands)

    Bos, J.

    1994-01-01

    Strategic planning is important in forest management. However, it has never been described clearly in literature. In this study a framework for strategic planning was developed and based on this a STrategic Alternatives Generating System (STAGES) to support decision making in strategic

  1. Sexual Violence Prevention: The Role of Stages of Change

    Science.gov (United States)

    Banyard, Victoria L.; Eckstein, Robert P.; Moynihan, Mary M.

    2010-01-01

    Increasing numbers of empirical studies and theoretical frameworks for preventing sexual violence are appearing in the research- and practice-based literatures. The consensus of this work is that although important lessons have been learned, the field is still in the early stages of developing and fully researching effective models, particularly…

  2. ART STAGE SINGAPORE THE NEW DESTINATION FOR THE ART WORLD

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    ASlA’S NEW INTERNATIONAL TOP CONTEMPORARY ART FAIR Art Stage Singapore supports and protects the interests of Asian galleries by elevating them to a level of international importance in order to help propel them as strong and competitive players in the global market. Therefore,the heart of the fair is made up of the best and most exciting of Asia’s artistic creativity,showcasing Asia’s most important

  3. Important advances in malaria vaccine research

    Directory of Open Access Journals (Sweden)

    Priyanka Jadhav

    2012-01-01

    Full Text Available Malaria is one of the most widespread parasitic infection in Asian countries affecting the poor of the poor. In an effort to develop an effective vaccine for the treatment of malaria, various attempts are being made worldwide. If successful, such a vaccine can be effective for treatment of both Plasmodium vivax and Plasmodium falciparum. This would also be able to avoid complications such as drug resistance, resistance to insecticides, nonadherence to the treatment schedule, and eventually high cost of treatment in the resource-limited settings. In the current compilation, the details from the literature were collected by using PubMed and Medline as search engines and searched for terms such as malaria, vaccine, and malaria treatment. This review collates and provides glimpses of the information on the recent malaria vaccine development. The reader will be taken through the historical perspective followed by the approaches to the malaria vaccine development from pre-erythrocytic stage vaccines, asexual stage vaccines, transmission blocking vaccines, etc. Looking at the current scenario of the malaria and treatment strategies, it is an absolute need of an hour that an effective malaria vaccine should be developed. This would bring a revolutionary breakthrough in the treatment modalities especially when there is increasing emergence of resistance to existing drug therapy. It would be of great purpose to serve those living in malaria endemic region and also for travelers which are nonimmune and coming to malaria endemic region. As infection by P. vivax is more prevalent in India and other Asian subcontinent and is often prominent in areas where elimination is being attempted, special consideration is required of the role of vaccines in blocking transmission, regardless of the stages being targeted. Development of vaccines is feasible but with the support of private sector and government organization in terms of regulatory and most importantly

  4. FASTER: an unsupervised fully automated sleep staging method for mice.

    Science.gov (United States)

    Sunagawa, Genshiro A; Séi, Hiroyoshi; Shimba, Shigeki; Urade, Yoshihiro; Ueda, Hiroki R

    2013-06-01

    Identifying the stages of sleep, or sleep staging, is an unavoidable step in sleep research and typically requires visual inspection of electroencephalography (EEG) and electromyography (EMG) data. Currently, scoring is slow, biased and prone to error by humans and thus is the most important bottleneck for large-scale sleep research in animals. We have developed an unsupervised, fully automated sleep staging method for mice that allows less subjective and high-throughput evaluation of sleep. Fully Automated Sleep sTaging method via EEG/EMG Recordings (FASTER) is based on nonparametric density estimation clustering of comprehensive EEG/EMG power spectra. FASTER can accurately identify sleep patterns in mice that have been perturbed by drugs or by genetic modification of a clock gene. The overall accuracy is over 90% in every group. 24-h data are staged by a laptop computer in 10 min, which is faster than an experienced human rater. Dramatically improving the sleep staging process in both quality and throughput FASTER will open the door to quantitative and comprehensive animal sleep research. © 2013 The Authors Genes to Cells © 2013 by the Molecular Biology Society of Japan and Wiley Publishing Asia Pty Ltd.

  5. [Staging urinary bladder cancer with dynamic MR imaging].

    Science.gov (United States)

    Tsuda, K; Narumi, Y; Nakamura, H; Nonomura, I; Okuyama, A

    2000-11-01

    This article reviews the magnetic resonance (MR) staging of bladder cancer. The multiplanar and soft-tissue characterization capabilities of MR imaging make it a valuable diagnostic tool to image the urinary bladder. Recent advances of MR imaging such as fast imaging, pelvic phased array coil, and dynamic imaging improve the image quality and diagnostic accuracy for staging bladder cancer. Some patient-related factors are also important for optimal imaging of the urinary bladder, especially motion artifacts from the gastrointestinal tract and the degree of bladder distension. An anticholinergic agent should be used for suppressing the motion artifacts. Optimal bladder filling can be achieved by asking patients to void and drink water 1 hour before examinations. Scanning perpendicular to the bladder wall is necessary for optimal evaluation for staging bladder cancer. Oblique scanning is needed in cases when a tumor is not located on the dome, base, anterior wall, posterior wall, or lateral walls. The early phase image of dynamic imaging is most useful for staging tumors. Better contrast between tumor and bladder wall on dynamic images provides high staging accuracy, especially in differentiation between superficial tumors and tumors with muscle invasion. MR imaging is comparable to computed tomography (CT) in the evaluation of lymph nodes. Although MR imaging currently is not appropriate for screening for bladder cancer and detecting small tumors, it has been proved to be most useful in the staging of bladder cancer.

  6. Habitat Fragmentation Drives Plant Community Assembly Processes across Life Stages.

    Science.gov (United States)

    Hu, Guang; Feeley, Kenneth J; Yu, Mingjian

    2016-01-01

    Habitat fragmentation is one of the principal causes of biodiversity loss and hence understanding its impacts on community assembly and disassembly is an important topic in ecology. We studied the relationships between fragmentation and community assembly processes in the land-bridge island system of Thousand Island Lake in East China. We focused on the changes in species diversity and phylogenetic diversity that occurred between life stages of woody plants growing on these islands. The observed diversities were compared with the expected diversities from random null models to characterize assembly processes. Regression tree analysis was used to illustrate the relationships between island attributes and community assembly processes. We found that different assembly processes predominate in the seedlings-to-saplings life-stage transition (SS) vs. the saplings-to-trees transition (ST). Island area was the main attribute driving the assembly process in SS. In ST, island isolation was more important. Within a fragmented landscape, the factors driving community assembly processes were found to differ between life stage transitions. Environmental filtering had a strong effect on the seedlings-to-saplings life-stage transition. Habitat isolation and dispersal limitation influenced all plant life stages, but had a weaker effect on communities than area. These findings add to our understanding of the processes driving community assembly and species coexistence in the context of pervasive and widespread habitat loss and fragmentation.

  7. Stages in the research process.

    Science.gov (United States)

    Gelling, Leslie

    2015-03-01

    Research should be conducted in a systematic manner, allowing the researcher to progress from a general idea or clinical problem to scientifically rigorous research findings that enable new developments to improve clinical practice. Using a research process helps guide this process. This article is the first in a 26-part series on nursing research. It examines the process that is common to all research, and provides insights into ten different stages of this process: developing the research question, searching and evaluating the literature, selecting the research approach, selecting research methods, gaining access to the research site and data, pilot study, sampling and recruitment, data collection, data analysis, and dissemination of results and implementation of findings.

  8. The Nuclear Cryogenic Propulsion Stage

    Science.gov (United States)

    Houts, Michael G.; Kim, Tony; Emrich, William J.; Hickman, Robert R.; Broadway, Jeramie W.; Gerrish, Harold P.; Doughty, Glen; Belvin, Anthony; Borowski, Stanley K.; Scott, John

    2014-01-01

    The fundamental capability of Nuclear Thermal Propulsion (NTP) is game changing for space exploration. A first generation Nuclear Cryogenic Propulsion Stage (NCPS) based on NTP could provide high thrust at a specific impulse above 900 s, roughly double that of state of the art chemical engines. Characteristics of fission and NTP indicate that useful first generation systems will provide a foundation for future systems with extremely high performance. The role of the NCPS in the development of advanced nuclear propulsion systems could be analogous to the role of the DC-3 in the development of advanced aviation. Progress made under the NCPS project could help enable both advanced NTP and advanced Nuclear Electric Propulsion (NEP). Nuclear propulsion can be affordable and viable compared to other propulsion systems and must overcome a biased public fear due to hyper-environmentalism and a false perception of radiation and explosion risk.

  9. Interconnected Levels of Multi-Stage Marketing

    DEFF Research Database (Denmark)

    Vedel, Mette; Geersbro, Jens; Ritter, Thomas

    2012-01-01

    different levels of multi-stage marketing and illustrates these stages with a case study. In addition, a triadic perspective is introduced as an analytical tool for multi-stage marketing research. The results from the case study indicate that multi-stage marketing exists on different levels. Thus, managers...... in a multi-stage marketing context. This understanding assists managers in assessing and balancing different aspects of multi- stage marketing. The triadic perspective also offers avenues for further research.......Multi-stage marketing gains increasing attention as knowledge of and influence on the customer's customer become more critical for the firm's success. Despite this increasing managerial relevance, systematic approaches for analyzing multi-stage marketing are still missing. This paper conceptualizes...

  10. Stage at diagnosis and ovarian cancer survival

    DEFF Research Database (Denmark)

    Maringe, Camille; Walters, Sarah; Butler, John;

    2012-01-01

    We investigate what role stage at diagnosis bears in international differences in ovarian cancer survival.......We investigate what role stage at diagnosis bears in international differences in ovarian cancer survival....

  11. Interconnected Levels of Multi-Stage Marketing

    DEFF Research Database (Denmark)

    Vedel, Mette; Geersbro, Jens; Ritter, Thomas

    2012-01-01

    must not only decide in general on the merits of multi-stage marketing for their firm, but must also decide on which level they will engage in multi-stage marketing. The triadic perspective enables a rich and multi-dimensional understanding of how different business relationships influence each other......Multi-stage marketing gains increasing attention as knowledge of and influence on the customer's customer become more critical for the firm's success. Despite this increasing managerial relevance, systematic approaches for analyzing multi-stage marketing are still missing. This paper conceptualizes...... different levels of multi-stage marketing and illustrates these stages with a case study. In addition, a triadic perspective is introduced as an analytical tool for multi-stage marketing research. The results from the case study indicate that multi-stage marketing exists on different levels. Thus, managers...

  12. What We Offer | FNLCR Staging

    Science.gov (United States)

    Opportunities We recognize that employee benefit programs are an important part of the total compensation package, and are committed to providing you with comprehensive benefit options. The Frederick National Lab's prime contractor, Leidos Biomedi

  13. The New Lung Cancer Staging System

    Institute of Scientific and Technical Information of China (English)

    Frank C. Detterbeck,MD, FCCP; Daniel J. Boffa, MD; Lynn T, Tanoue, MD, FCCP

    2009-01-01

    The International Association for the Study of Lung Cancer (IASLC) has conducted an extensive initiative to inform the revision of the lung cancer staging system. This involved development of an international database along with extensive analysis of a large population of patients and their prognoses. This article reviews the recommendations of the IASLC International Staging Committee for the definitions for the TNM descriptors and the stage grouping in the new non-small cell lung cancer staging system.

  14. Two Stage Gear Tooth Dynamics Program

    Science.gov (United States)

    1989-08-01

    cordi - tions and associated iteration prooedure become more complex. This is due to both the increased number of components and to the time for a...solved for each stage in the two stage solution . There are (3 + ntrrber of planets) degrees of freedom fcr eacb stage plus two degrees of freedom...should be devised. It should be noted that this is not minor task. In general, each stage plus an input or output shaft will have 2 times (4 + number

  15. [Develpment of sleep stages in childhood].

    Science.gov (United States)

    Geib, Lorena Teresinha Consalter

    2007-01-01

    With the perspective of describing some aspects of the ontogenesis and organization of the sleep stages during the first year of life, a literature review was carried out to assess the physiological and behavioral alterations controlled by changes occurring during sleep at this developmental stage. In addition, based on the sleep preceding theory the stages of differentiation, classification and time organization of sleep stages are presented, aiming at the favorable management of environmental events that affect the organization of infant sleep.

  16. Between Stage and Screen : Ingmar Bergman Directs

    OpenAIRE

    1996-01-01

    Ingmar Bergman is worldwide known as a film and stage director. Yet no-one has attempted to compare his stage and screen activities. In Between stage and screen Egil Törnqvist examines formal and thematical correspondences and differences between a number of Bergman's stage, screen, and radio productions. In the prologue Bergman's spiritual and aesthetic heritage and his position in the twentieth century media landscape is outlined. In the epilogue the question is answered to what extent one ...

  17. TNM Staging of Colorectal Cancer Should be Reconsidered According to Weighting of the T Stage

    Science.gov (United States)

    Li, Jun; Yi, Cheng-Hao; Hu, Ye-Ting; Li, Jin-Song; Yuan, Ying; Zhang, Su-Zhan; Zheng, Shu; Ding, Ke-Feng

    2016-01-01

    Abstract The gradient monotonicity of existing tumor, node, metastases staging systems for colorectal cancer is unsatisfactory. Our proposed T-plus staging system strengthens weighting of the T stage. In this study, applicability of the T-plus staging system was verified with data of a Chinese colorectal cancer center. Records of 2080 nonmetastatic, advanced cancer patients undergoing colorectal cancer surgery from 1985 to 2011 were reviewed for T, N stage pathology and follow-up information. Using overall and disease-specific survival data, the 7th edition tumor, node, metastases staging system and the T-plus staging system were compared for stage homogeneity and discrimination and gradient monotonicity. For gradient monotonicity, the T-plus staging system was superior for both colon and rectal cancer. With Kaplan–Meier survival curves, the T-plus staging system discriminated among different stages, and the corresponding survival was inversely associated with the stage. However, for the 7th edition tumor, node, metastases staging system, stage IIIa had a better prognosis than stage II for rectal cancer and stage I for colon cancer. For homogeneity within the same stage and discrimination between different stages, the 2 staging systems were similar for colorectal cancer, but the T-plus system was clearly better for colon cancer. The T-plus staging system provides good gradient monotonicity. For future colorectal cancer staging systems, we propose replacement of lymph node status as the criterion to discriminate colorectal cancer stage II and stage III with greater weighting of the T stage. PMID:26871810

  18. The importance of robust design methodology

    DEFF Research Database (Denmark)

    Eifler, Tobias; Howard, Thomas J.

    2017-01-01

    While a systematic quality strategy is of crucial importance for the success of manufacturing companies, the universal applicability and effectiveness of implemented quality management practices were called into question by a number of major product recalls in recent years. This article seeks...... to illustrate how already simple analyses and early stage design methods can help to better understand one of the potential reasons for these failures, namely the variation inherent in manufacturing, assembly, and use processes. Usually thoroughly controlled in production, it seems as if particularly the risk...... of unanticipated variation effects remain largely underestimated and thus unaccounted for in design practice, sometimes with disastrous consequences. To foster the awareness of this variation and to illustrate the benefits of its early consideration in product development, this paper reviews one of the most...

  19. The most important tool in MLM-business

    Directory of Open Access Journals (Sweden)

    N.G. Gromyko

    2011-03-01

    Full Text Available In article it is considered one of the most important tools in work of the distributor. The purposes which are pursued by consideration and application of the author's approach to this point in question are opened. Stages of the offered approach, their results, a role and value in MLM are in details stated the industry.

  20. Blood parasites in reptiles imported to Germany.

    Science.gov (United States)

    Halla, Ursula; Ursula, Halla; Korbel, Rüdiger; Rüdiger, Korbel; Mutschmann, Frank; Frank, Mutschmann; Rinder, Monika; Monika, Rinder

    2014-12-01

    Though international trade is increasing, the significance of imported reptiles as carriers of pathogens with relevance to animal and human health is largely unknown. Reptiles imported to Germany were therefore investigated for blood parasites using light microscopy, and the detected parasites were morphologically characterized. Four hundred ten reptiles belonging to 17 species originating from 11 Asian, South American and African countries were included. Parasites were detected in 117 (29%) of individual reptiles and in 12 species. Haemococcidea (Haemogregarina, Hepatozoon, Schellackia) were found in 84% of snakes (Python regius, Corallus caninus), 20% of lizards (Acanthocercus atricollis, Agama agama, Kinyongia fischeri, Gekko gecko) and 50% of turtles (Pelusios castaneus). Infections with Hematozoea (Plasmodium, Sauroplasma) were detected in 14% of lizards (Acanthocercus atricollis, Agama agama, Agama mwanzae, K. fischeri, Furcifer pardalis, Xenagama batillifera, Acanthosaura capra, Physignathus cocincinus), while those with Kinetoplastea (Trypanosoma) were found in 9% of snakes (Python regius, Corallus caninus) and 25 % of lizards (K. fischeri, Acanthosaura capra, G. gecko). Nematoda including filarial larvae parasitized in 10% of lizards (Agama agama, Agama mwanzae, K. fischeri, Fu. pardalis, Physignathus cocincinus). Light microscopy mostly allowed diagnosis of the parasites' genus, while species identification was not possible because of limited morphological characteristics available for parasitic developmental stages. The investigation revealed a high percentage of imported reptiles being carriers of parasites while possible vectors and pathogenicity are largely unknown so far. The spreading of haemoparasites thus represents an incalculable risk for pet reptiles, native herpetofauna and even human beings.

  1. Important Aspects of Nutrition in Children with Cancer1

    OpenAIRE

    Bauer, Jacqueline; Jürgens, Heribert; Frühwald, Michael C.

    2011-01-01

    Adequate nutrition during cancer plays a decisive role in several clinical outcome measures, such as treatment response, quality of life, and cost of care. However, the importance of nutrition in children and young adults with malignancies is still an underestimated topic within pediatric oncology. The importance of our work is to reinforce and indicate that malnutrition in children with cancer should not be accepted at any stage of the disease or tolerated as an inevitable process. Unique to...

  2. Canine stage 1 periodontal disease: a latent pathology.

    Science.gov (United States)

    Whyte, A; Bonastre, C; Monteagudo, L V; Les, F; Obon, J; Whyte, J; Tejedor, M T

    2014-07-01

    To evaluate the potential health issues associated with periodontal disease (PD) in dogs, 1004 teeth from 25 dogs were examined. The dogs were randomly selected, aged 2-14 years, and had at least 95% of their teeth at the first PD stage. Significant positive correlations between plaque grade (PG) and gum inflammation, gingival regression, periodontal pocket, age and serum alanine aminotransferase (ALT) activity were identified. In contrast, PG was negatively correlated to total platelet count. Altogether, these findings suggest that prevention and therapy at the first PD stages can have an important impact on the general health condition of dogs.

  3. STAGE OF TEXTILE RECYCLE WASTE IN ROMANIA

    Directory of Open Access Journals (Sweden)

    TRIPA Simona

    2014-05-01

    Full Text Available Aim of this article is to examine the stage of textile recycle waste in Romania. For this purpose were analyzed the main sources of textile waste from Romania (industry of manufacture of textiles, wearing apparel, leather and related products, imports of textiles, clothing and footwear and imports of second hand clothing and also evolution of the quantity of textile waste in Romania. The benefits (economic and environmental of the collection and recycling of waste and the legislation on the waste management, have determined the diversification and increasing the number and the capacity of recovery and disposal of waste in Romania. We found the most textile waste in Romania was deposited in deposits onto or into land, in the proportion of 18.51%. This proportion is under the EU average of 34.03%, but is much higher than in other European country. Also, has been an increase in the number of incinerators, in the last years. With all of this, the interest in textile waste management in Romania is far from being to the level of European, where are associations who dealing with the collection and recycling of textiles and is achieved a selective collection of textile waste in the points especially designed for this thing. The information for this paper was gathered from literature, from the EUROSTAT database and INSSE database analysis and by Internet.

  4. PARALLEL IMPORT: REALITY FOR RUSSIA

    Directory of Open Access Journals (Sweden)

    Т. А. Сухопарова

    2014-01-01

    Full Text Available Problem of parallel import is urgent question at now. Parallel import legalization in Russia is expedient. Such statement based on opposite experts opinion analysis. At the same time it’s necessary to negative consequences consider of this decision and to apply remedies to its minimization.Purchase on Elibrary.ru > Buy now

  5. Textile Machinery: Imports Rebound Again

    Institute of Scientific and Technical Information of China (English)

    Zheng Yan

    2007-01-01

    @@ In the year of 2006, the general situation of China's textile machinery equipment imports had shown a clear sign of revival from the downward trend of two years ago, with a total annual import of 4.1 billion USD, an increase of 19.05% against the same period of 2005.

  6. PHARMACOLOGICAL IMPORTANCE OF CITRUS FRUITS

    Directory of Open Access Journals (Sweden)

    Amita Tomar *, Mridula Mall and Pragya Rai

    2013-01-01

    Full Text Available This paper reviews the pharmacological importance of citrus fruits. Citrus fruits are used for various pharmacological importance. According to literature the citrus fruit possess anti-cancer, antimicrobial, antioxidant, antiulcer, anti-inflammatory, and hypolipidemic and hepatoprotective properties.

  7. Tumbling Auto Import and Export

    Institute of Scientific and Technical Information of China (English)

    Yantai Chen

    2009-01-01

    @@ The seemingly rebound global financial crisis has seriously eroded world economy from 2008,of which China's tumbling auto imports and exports business is a good example.At the beginning of 2008 it kicked off as an excellent year for the Chinese automotive market,but ended with the onset of a recession in last quarter both from the perspective of import and export.

  8. The Nuclear Cryogenic Propulsion Stage

    Science.gov (United States)

    Houts, Michael G.; Kim, Tony; Emrich, William J.; Hickman, Robert R.; Broadway, Jeramie W.; Gerrish, Harold P.; Belvin, Anthony D.; Borowski, Stanley K.; Scott, John H.

    2014-01-01

    Nuclear Thermal Propulsion (NTP) development efforts in the United States have demonstrated the technical viability and performance potential of NTP systems. For example, Project Rover (1955 - 1973) completed 22 high power rocket reactor tests. Peak performances included operating at an average hydrogen exhaust temperature of 2550 K and a peak fuel power density of 5200 MW/m3 (Pewee test), operating at a thrust of 930 kN (Phoebus-2A test), and operating for 62.7 minutes in a single burn (NRX-A6 test). Results from Project Rover indicated that an NTP system with a high thrust-to-weight ratio and a specific impulse greater than 900 s would be feasible. Excellent results were also obtained by the former Soviet Union. Although historical programs had promising results, many factors would affect the development of a 21st century nuclear thermal rocket (NTR). Test facilities built in the US during Project Rover no longer exist. However, advances in analytical techniques, the ability to utilize or adapt existing facilities and infrastructure, and the ability to develop a limited number of new test facilities may enable affordable development, qualification, and utilization of a Nuclear Cryogenic Propulsion Stage (NCPS). Bead-loaded graphite fuel was utilized throughout the Rover/NERVA program, and coated graphite composite fuel (tested in the Nuclear Furnace) and cermet fuel both show potential for even higher performance than that demonstrated in the Rover/NERVA engine tests.. NASA's NCPS project was initiated in October, 2011, with the goal of assessing the affordability and viability of an NCPS. FY 2014 activities are focused on fabrication and test (non-nuclear) of both coated graphite composite fuel elements and cermet fuel elements. Additional activities include developing a pre-conceptual design of the NCPS stage and evaluating affordable strategies for NCPS development, qualification, and utilization. NCPS stage designs are focused on supporting human Mars

  9. Enhancing importance-performance analysis

    DEFF Research Database (Denmark)

    Eskildsen, Jacob Kjær; Kristensen, Kai

    2006-01-01

    Purpose: The interpretation of the importance/performance map is based on an assumption of independence between importance and performance but many studies question the validity of this assumption. The aim of this research is to develop a new typology for job satisfaction attributes as well...... as a new importance/performance map that can be an aid for organizations when they prioritize their improvement actions based on a job satisfaction study. Design/methodology/approach: A typology for possible relationships between importance and performance in job satisfaction studies is developed based...... on theoretical considerations. This typology is then applied and validated on approximately 10,000 responses from the European Employee Index 2002. Ultimately a new importance/performance map for priority setting in job satisfaction studies is developed based on the new typology for possible relationships...

  10. Enhancing importance-performance analysis

    DEFF Research Database (Denmark)

    Eskildsen, Jacob Kjær; Kristensen, Kai

    2006-01-01

    on theoretical considerations. This typology is then applied and validated on approximately 10,000 responses from the European Employee Index 2002. Ultimately a new importance/performance map for priority setting in job satisfaction studies is developed based on the new typology for possible relationships......Purpose: The interpretation of the importance/performance map is based on an assumption of independence between importance and performance but many studies question the validity of this assumption. The aim of this research is to develop a new typology for job satisfaction attributes as well...... as a new importance/performance map that can be an aid for organizations when they prioritize their improvement actions based on a job satisfaction study. Design/methodology/approach: A typology for possible relationships between importance and performance in job satisfaction studies is developed based...

  11. Three stage semelparous Leslie models.

    Science.gov (United States)

    Cushing, J M

    2009-07-01

    oscillations (not necessarily periodic) with separated life-cycle stages, while weak interactions promote stable equilibration with overlapping life-cycle stages. Methods used include the theory of planar monotone maps, average Lyapunov functions, and bifurcation theory techniques.

  12. Optimum Staging with Varying Thrust Attitude Angle

    Directory of Open Access Journals (Sweden)

    T. N. Srivastava

    1966-07-01

    Full Text Available Optimum staging programme for step rockets of arbitrary number of stages having different specific impulses and mass fractions with stages is derived, the optimization criterion being minimum take-off weight for a desired burntout velocity at an assigned altitude. Variation of thrust attitude angle from stage to stage and effects of gravity factor are taken into account. Analysis is performed for a degenerate problem obtained by relaxing the altitude constraint and it has been shown that problems of Weisbord, Subotowicz, Hall & Zambelli and Malina & Summerfield are the particular cases of the degenerate problem.

  13. TNM staging of colorectal cancer should be reconsidered by T stage weighting

    Science.gov (United States)

    Li, Jun; Guo, Bao-Cai; Sun, Li-Rong; Wang, Jian-Wei; Fu, Xian-Hua; Zhang, Su-Zhan; Poston, Graeme; Ding, Ke-Feng

    2014-01-01

    AIM: To verify that the T stage has greater weight than the N stage in the staging of colorectal cancer. METHODS: Open data from the Surveillance, Epidemiology, and End Results program were reviewed and analyzed according to the T stage, N stage, and patients’ observed survival (OS). The relative weights of the T and N stages were calculated by multiple linear regressions based on their impact on survival. Risk scores for 25 TN categories were then calculated from the T and N stage relative weights, and a rearranged tumor node metastasis (TNM) staging system was proposed via a cluster analysis of the TN scores. RESULTS: Both T and N stages significantly affect the OS of patients with colorectal cancer. Moreover, the T stage has greater weight than the N stage in the TNM staging system of colorectal cancer. For colon cancer, the relative T and N stage weights were 0.58 and 0.42, respectively, and for rectal cancer, the relative T and N stage weights were 0.61 and 0.39, respectively. On the basis of cluster analysis of the TN scores, T1N1a was classified to stage I, and T2N1a-1b and T1N1b-2a were classified to stage II in our revised TNM staging system for both colon and rectal cancer. For colon cancer, T4bN0 was classified to stage IIIa, but for rectal cancer, it was classified to stage IIIb. CONCLUSION: As the T stage affects colorectal cancer survival more significantly than the N stage, the TNM staging should be revised by relative T stage weight. PMID:24803826

  14. TNM staging of colorectal cancer should be reconsidered by T stage weighting.

    Science.gov (United States)

    Li, Jun; Guo, Bao-Cai; Sun, Li-Rong; Wang, Jian-Wei; Fu, Xian-Hua; Zhang, Su-Zhan; Poston, Graeme; Ding, Ke-Feng

    2014-05-07

    To verify that the T stage has greater weight than the N stage in the staging of colorectal cancer. Open data from the Surveillance, Epidemiology, and End Results program were reviewed and analyzed according to the T stage, N stage, and patients' observed survival (OS). The relative weights of the T and N stages were calculated by multiple linear regressions based on their impact on survival. Risk scores for 25 TN categories were then calculated from the T and N stage relative weights, and a rearranged tumor node metastasis (TNM) staging system was proposed via a cluster analysis of the TN scores. Both T and N stages significantly affect the OS of patients with colorectal cancer. Moreover, the T stage has greater weight than the N stage in the TNM staging system of colorectal cancer. For colon cancer, the relative T and N stage weights were 0.58 and 0.42, respectively, and for rectal cancer, the relative T and N stage weights were 0.61 and 0.39, respectively. On the basis of cluster analysis of the TN scores, T1N1a was classified to stage I, and T2N1a-1b and T1N1b-2a were classified to stage II in our revised TNM staging system for both colon and rectal cancer. For colon cancer, T4bN0 was classified to stage IIIa, but for rectal cancer, it was classified to stage IIIb. As the T stage affects colorectal cancer survival more significantly than the N stage, the TNM staging should be revised by relative T stage weight.

  15. Neutron interferometry with cold stage

    Science.gov (United States)

    Mineeva, Taisiya; Arif, M.; Huber, M. G.; Shahi, C. B.; Clark, C. W.; Cory, D. G.; Nsofini, J.; Sarenac, D.; Pushin, D. A.

    Neutron interferometry (NI) is amongst the most precise methods for characterizing neutron interactions by measuring the relative difference between two neutron paths, one of which contains a sample-of-interest. Because neutrons carry magnetic moment and are deeply penetrating, they are excellent probes to investigate properties of magnetic materials. The advantage of NI is its unique sensitivity which allows to directly measure magnetic and structural transitions in materials. Up to now NI has been sparingly used in material research due to its sensitivity to environmental noise. However, recent successes in implementing Quantum Error Correction principles lead to an improved NI design making it robust against mechanical vibrations. Following these advances, a new user facility at the National Institute for Standards and Technology was built to study condensed matter applications, biology and quantum physics. Incorporating cold sample stage inside NI is the first of its kind experiment which can be carried out on large range of temperatures down to 4K. Upon successful realization, it will open new frontiers to characterize magnetic domains, phase transitions and spin properties in a variety of materials such as, for example, iron-based superconductors and spintronic materials. Supported in part by CERC, CIFAR, NSERC and CREATE.

  16. Freedom and the Ibsen Stage

    Institute of Scientific and Technical Information of China (English)

    Asbjφrn Aarseth

    2005-01-01

    To some extent Ibsen's career as a dramatist was conditioned by the physical limitations of the theatre buildings. He succeeded in turning these limitations to his advantage. Through dialogue and scenography he tried to achieve a longing in the audience to see the characters succeed in getting out of oppressive, prisonlike conditions. Gradually concentrating the action in the narrow room, he succeeded in achieving the effect of claustrophobia particularly in his work in the years 1877-86. After that he experimented in bringing the basic narrowness out in the open air scenography in 1888 with The Lady from the Sea. In Hedda Gabler and partly in John Gabriel Borkman he returned to the interior stage, but in the rest of the 1890s he preferred to situate some or most of the action in the open air. This selfimposed constriction is capable of producing an intense experience exactly because the urge to be free is amplified by the physical narrowness. Consequently it has proved difficult to make a successful movie on the basis of a modern prose play by Ibsen. The moving camera tends to dissolve the spatial limitations.

  17. IMPORTANT NEMATODE INFECTIONS IN INDONESIA

    Directory of Open Access Journals (Sweden)

    Sri Oemijati

    2012-09-01

    Full Text Available At least 13 species of intestinal nematodes and 4 species of blood and tissue nematodes have been reported infecting man in Indonesia. Five species of intestinal nematodes are very common and highly prevalent, especially in the rural areas and slums of the big cities. Those species are Ascaris lumbricoides, Necator americanus, Ancylostoma duodenale, Trichuris trichiura and Oxyuris vermicularis, while Strongyloides stercoralis is disappearing. The prevalence of the soil transmitted helminths differs from place to place, depending on many factors such as the type of soil, human behaviour etc. Three species of lymph dwelling filarial worms are known to be endemic, the urban Wuchereria bancrofti is low endemic in Jakarta and a few other cities along the north coast of Java, with Culex incriminated as vector, high endemicity is found in Irian Jaya, where Anopheline mosquitoes act as vectors. Brugia malayi is widely distributed and is still highly endemic in many areas. The zoonotic type is mainly endemic in swampy areas, and has many species of Mansonia mosquitoes as vectors. B.timori so far has been found only in the south eastern part of the archipelago and has Anopheles barbirostris as vector. Human infections with animal parasites have been diagnosed properly only when adult stages were found either in autopsies or removed tissues. Cases of infections with A. caninum, A.braziliense, A.ceylanicum, Trichostrongylus colubriformis, T.axei and Oesophagostomum apiostomum have been desribed from autopsies, while infections with Gnathostoma spiningerum have been reported from removed tissues. Infections with the larval stages such as VLM, eosinophylic meningitis, occult filanasis and other could only be suspected, since the diagnosis was extremely difficult and based on the finding and identification of the parasite. Many cases of creeping eruption which might be caused by the larval stages of A.caninum and A.braziliense and Strongyloides stercoralis

  18. IMPORTANT NEMATODE INFECTIONS IN INDONESIA

    Directory of Open Access Journals (Sweden)

    Sri Oemijati

    2012-09-01

    Full Text Available At least 13 species of intestinal nematodes and 4 species of blood and tissue nematodes have been reported infecting man in Indonesia. Five species of intestinal nematodes are very common and highly prevalent, especially in the rural areas and slums of the big cities. Those species are Ascaris lumbricoides, Necator americanus, Ancylostoma duodenale, Trichuris trichiura and Oxyuris vermicularis, while Strongyloides stercoralis is disappearing. The prevalence of the soil transmitted helminths differs from place to place, depending on many factors such as the type of soil, human behaviour etc. Three species of lymph dwelling filarial worms are known to be endemic, the urban Wuchereria bancrofti is low endemic in Jakarta and a few other cities along the north coast of Java, with Culex incriminated as vector, high endemicity is found in Irian Jaya, where Anopheline mosquitoes act as vectors. Brugia malayi is widely distributed and is still highly endemic in many areas. The zoonotic type is mainly endemic in swampy areas, and has many species of Mansonia mosquitoes as vectors. B.timori so far has been found only in the south eastern part of the archipelago and has Anopheles barbirostris as vector. Human infections with animal parasites have been diagnosed properly only when adult stages were found either in autopsies or removed tissues. Cases of infections with A. caninum, A.braziliense, A.ceylanicum, Trichostrongylus colubriformis, T.axei and Oesophagostomum apiostomum have been desribed from autopsies, while infections with Gnathostoma spiningerum have been reported from removed tissues. Infections with the larval stages such as VLM, eosinophylic meningitis, occult filanasis and other could only be suspected, since the diagnosis was extremely difficult and based on the finding and identification of the parasite. Many cases of creeping eruption which might be caused by the larval stages of A.caninum and A.braziliense and Strongyloides stercoralis

  19. Policy implications of drug importation.

    Science.gov (United States)

    Palumbo, Francis B; Mullins, C Daniel; Slagle, Ashley F; Rizer, Jessica

    2007-12-01

    Importation of prescription drugs into the United States has been a major health policy issue for some time. The original objective of personal importation was to allow patients to have access to drugs that were not available to them in the United States either for continuation of therapy begun in another country or when all US Food and Drug Administration (FDA)-approved drug options for their condition had been exhausted. An increasing proportion of personally imported drugs are currently marketed in the United States, but imported drugs are presumably available at a lower cost to the consumer. As US consumers opt for importation through Internet sites and other means of purchase from other countries, potential risks of exposure to counterfeit products have increased, presenting challenges to both the US regulatory system and pharmaceutical companies. This commentary summarizes the current state of importation of prescription drugs into the United States. Regulators and policymakers are under increasing pressure to address the high cost of branded drugs in the United States and the desires of many US patients to purchase less expensive formulations of these products through importation. In many cases, the historical policies surrounding personal importation of prescription drugs that are not sold in the United States have been blatantly ignored, leaving the FDA in a quandary. While current legislative proposals would allow for greater access to drugs directly to consumers from other countries, they do not address the fact that the FDA has no ability to monitor the safety and efficacy of imported products. As such, the possibility of the entry of counterfeit medications and the related potential harm remain concerns.

  20. Refelecteren op stage-ervaringen

    NARCIS (Netherlands)

    Bolhuis-Poortvliet, Grietje Anna van; Snoek, Johannes Petrus Adrianus

    1996-01-01

    In vocational education it is very important for students to receive part of their training in a real-life situation. Most of the Dutch vocational colleges organize a practical training in a work setting that is relevant to the students' chosen field of study. Through practical training, students

  1. Tax Adjusted for Imported Equipment

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    @@ Ministry of Finance, Central Administration of Customs, and State Administration of Taxation of P.R. of China jointly issued a "Notice on the Lists Related to the Interim Provisions on the Adjustment of Import Tax Policy on Major Technical Equipment" (the Notice) on April 13rd to adjust the list of equipment catalog and merchandise attached to the "Interim Provisions on the Import Tax Policy on Major Technical Equipment", as well as the preferential scope and extent of the import tax on a number of major technical equipment.

  2. Staging of moyamoya disease by perfusion SPECT

    Energy Technology Data Exchange (ETDEWEB)

    Kuwabara, Yasuo [Kyushu Univ., Fukuoka (Japan). Hospital; Matsushima, Toshio; Fukui, Masashi

    2001-04-01

    Staging of moyamoya disease, based on angiography and PET have already been established. The authors have established staging of moyamoya disease based on perfusion SPECT, that can be summarized as follows: Stage I, no abnormality is seen at rest or after acetazolamide loading; Stage II, no abnormality is seen at rest, however, a decreased response (blood flow increase rate: <15%) is seen to acetazolamide loading (a, a decreased response is seen only in the frontal lobe; b, a decreased response is seen in regions other than the frontal lobe; and c, a decreased response is seen throughout the cerebrum); Stage III, localized decrease in blood flow (blood flow decrease compared with peripheral tissue: {>=}15%) and marked decrease in response to acetazolamide (blood flow increase rate: <5%) are seen at rest. In Stage III, CT and MRI show no abnormal findings or only mild lesions of the white matter; and Stage IV, multiple decreases in blood flow are seen at rest, and CT and MRI reveal infarctions and severe atrophy at the same sites. The above staging does not require determination of cerebral blood flow, and thus it can be used in children, in whom cerebral blood flow determination is difficult. The authors performed 99m-Tc ECD perfusion SPECT in 25 patients with moyamoya disease for the staging, and compared staging based on angiography with staging based on perfusion SPECT. The results did not show a correlation between the 2 staging methods. A problem inherent in the staging of moyamoya disease based on perfusion SPECT is that the relationship between cerebral blood flow and cerebral radioactivity concentrations may differ depending on the drug used to determine cerebral blood flow. Thus, although the present staging system does not depend on any specific radioactive drug to determine cerebral blood flow, further investigation is necessary to identify a more appropriate drug than those in current use. (K.H.)

  3. Two New Fourth-Order Three-Stage Symplectic Integrators

    Institute of Scientific and Technical Information of China (English)

    LI Rong; WU Xin

    2011-01-01

    Two new fourth-order three-stage symplectic integrators are specifically designed for a family of Hamiltonian systems,such as the harmonic oscillator,mathematical pendulum and lattice ψ4 model.When the nonintegrable lattice ψ4 system is taken as a test model,numerical comparisons show that the new methods have a great advantage over the second-order Verlet symplectic integrators in the accuracy of energy,become explicitly better than the usual non-gradient fourth-order seven-stage symplectic integrator of Forest and Ruth,and are almost equivalent to a fourth-order seven-stage force gradient symplectic integrator of Chin.As the most important advantage,the new integrators are convenient for solving the variational equations of many Hamiltonian systems so as to save a great deal of the computational cost when scanning a lot of orbits for chaos.

  4. EFFECTS OF IMPORTED GOODS ON EXPORT AND IMPORT OF TURKEY

    Directory of Open Access Journals (Sweden)

    MURAT SARI

    2014-05-01

    Full Text Available This study aims at analysing effects of intermediate goods, capital goods and consumer goods on both import and export, and at determining the subsector led to deficits of balance of payments. To achieve this, various statistical techniques have been applied. To carry out the present study, data reported by the Central Bank of Turkey were used in the time period of 2000–2013.These results revealed that the economic factors (intermediate, capital, consumer goods are significantly effective on the deficits of balance of payments. The analysis also showed that the corresponding imported goods are effective parameters onboth import and export. Contrary to common expectation, it is concluded that the deficits of balance of payments in the external trade of Turkey stem from the imports of the consumer goods. This study reveals that the policies should be created to encourage the decreasing of the items caused the deficits. It is important to note that our findings are usually in agreement with the literature. Possibility of countries’ involvement into economic crises can be determined before the crises take place and the countries will be therefore warned according to the results obtained. All graphical and statistical results here have been produced by the authors through EViews 7.1.

  5. Performance measurement of insurance firms using a two-stage DEA method

    Directory of Open Access Journals (Sweden)

    Raha Jalili Sabet

    2013-01-01

    Full Text Available Measuring the relative performance of insurance firms plays an important role in this industry. In this paper, we present a two-stage data envelopment analysis to measure the performance of insurance firms, which were active over the period of 2006-2010. The proposed study of this paper performs DEA method in two stages where the first stage considers five inputs and three outputs while the second stage considers the outputs of the first stage as the inputs of the second stage and uses three different outputs for this stage. The results of our survey have indicated that while there were 4 efficient insurance firms most other insurances were noticeably inefficient. This means market was monopolized mostly by a limited number of insurance firms and competition was not fare enough to let other firms participate in economy, more efficiently.

  6. The Importance of Longitudinal Studies

    Science.gov (United States)

    Knezek, Patricia

    2014-01-01

    It has been eight years since the AAS Council unanimously endorsed the document, known as "Equity Now: The Pasadena Recommendations for Gender Equality in Astronomy," in January 2005. This document was the main product of the conference entitled “Women in Astronomy II: Ten Years After” (WIA II), held in June 2003 in Pasadena, CA. One of the key recommendations represented in that document was the need for a longitudinal study of astronomers. It was recognized that in order to understand our own field, how it is evolving, and the impact on individuals, we need to track people over time. I will discuss the fundamental questions that led to the recommendation, and set the stage for the current (ongoing) longitudinal study.

  7. The importance of good seed

    Science.gov (United States)

    Robert P. Karrfalt

    2013-01-01

    The importance of seed to human culture and conservation of the natural world is briefly discussed. The effect of seed on seedling quality and cost is described through several examples and illustrations.

  8. Cyberbullying: Important Information for Parents

    Science.gov (United States)

    ... Life Listen Español Text Size Email Print Share Cyberbullying: Important Information for Parents Page Content Article Body ... space to any of our kids. What Makes Cyberbullying So Challenging? Kids do not report it to ...

  9. Staging of gastroenteropancreatic neuroendocrine tumors: how we do it based on an evidence-based approach.

    LENUS (Irish Health Repository)

    McDermott, Shaunagh

    2013-01-01

    In contrast to other common types of malignant tumors, the vast majority of gastroenteropancreatic neuroendocrine tumors are well differentiated and slowly growing with only a minority showing aggressive behavior. It is important to accurately stage patients radiologically so the correct treatment can be implemented and to improve prognosis. In this article, we critically appraise the current literature in an effort to establish the current role of radiologic imaging in the staging of neuroendocrine tumors. We also discuss our protocol for staging neuroendocrine tumors.

  10. Multi-stage FE simulation of hot ring rolling

    Science.gov (United States)

    Wang, C.; Geijselaers, H. J. M.; van den Boogaard, A. H.

    2013-05-01

    As a unique and important member of the metal forming family, ring rolling provides a cost effective process route to manufacture seamless rings. Applications of ring rolling cover a wide range of products in aerospace, automotive and civil engineering industries [1]. Above the recrystallization temperature of the material, hot ring rolling begins with the upsetting of the billet cut from raw stock. Next a punch pierces the hot upset billet to form a hole through the billet. This billet, referred to as preform, is then rolled by the ring rolling mill. For an accurate simulation of hot ring rolling, it is crucial to include the deformations, stresses and strains from the upsetting and piercing process as initial conditions for the rolling stage. In this work, multi-stage FE simulations of hot ring rolling process were performed by mapping the local deformation state of the workpiece from one step to the next one. The simulations of upsetting and piercing stages were carried out by 2D axisymmetric models using adaptive remeshing and element erosion. The workpiece for the ring rolling stage was subsequently obtained after performing a 2D to 3D mapping. The commercial FE package LS-DYNA was used for the study and user defined subroutines were implemented to complete the control algorithm. The simulation results were analyzed and also compared with those from the single-stage FE model of hot ring rolling.

  11. C-stage in colon cancer: implications of carcinoembryonic antigen biomarker in staging, prognosis, and management.

    Science.gov (United States)

    Thirunavukarasu, Pragatheeshwar; Sukumar, Shyamsunder; Sathaiah, Magesh; Mahan, Meredith; Pragatheeshwar, Kothai Divya; Pingpank, James F; Zeh, Herbert; Bartels, Christopher J; Lee, Kenneth K W; Bartlett, David L

    2011-04-20

    The American Joint Committee on Cancer (AJCC) has proposed the inclusion of pretreatment serum carcinoembryonic antigen (CEA) level (C-stage) into the conventional TNM staging system of colon cancer. We assessed the prognosis of various stages of colon cancer after such an inclusion. Data for all patients (N = 17 910) diagnosed with colonic adenocarcinoma (AJCC stages I, IIA, IIB, IIC, IIIA, IIIB, IIIC, and IV, based on TNM staging system) between January 1, 2004, and December 31, 2004, with a median follow-up of 27 months (range 0-35 months), were collected from the Surveillance, Epidemiology, and End Results database. C-stage (C0-stage = normal CEA level; C1-stage = elevated CEA level) was assigned to all patients with available CEA information (n = 9083). Multivariable analyses using Cox proportional hazards models were used to identify independent factors associated with prognosis. Prognosis of overall stages (AJCC stages I-IV and C0 or C1) was analyzed using Kaplan-Meier survival curves. All statistical tests were two-sided. C1-stage was independently associated with a 60% increased risk of overall mortality (hazard ratio of death = 1.60, 95% confidence interval = 1.46 to 1.76, P cancer compared with C0-stage cancer of the respective overall stages (P cancer compared with stage IIA C0 or stage IIIA C0 cancer (P cancer compared with stage IIIA C0 (P cancer compared with stage IIIB C0 cancer (P colon cancer. The results support routine preoperative CEA testing and C-staging upon diagnosis of colon cancer and the inclusion of C-stage in the conventional TNM staging of colon cancer.

  12. New procedures. Comprehensive staging of lung cancer by MRI; Neue Verfahren. Umfassendes Staging des Lungenkarzinoms mit der MRT

    Energy Technology Data Exchange (ETDEWEB)

    Hintze, C. [Universitaetsklinikum Schleswig-Holstein, Campus Kiel, Klinik fuer Diagnostische Radiologie, Kiel (Germany); Deutsches Krebsforschungszentrum (DKFZ) Heidelberg, Abteilung Radiologie (E010), Heidelberg (Germany); Dinkel, J. [Deutsches Krebsforschungszentrum (DKFZ) Heidelberg, Abteilung Radiologie (E010), Heidelberg (Germany); Biederer, J. [Universitaetsklinikum Schleswig-Holstein, Campus Kiel, Klinik fuer Diagnostische Radiologie, Kiel (Germany); Heussel, C.P. [Thoraxklinik Heidelberg, Abteilung Diagnostische und Interventionelle Radiologie, Heidelberg (Germany); Puderbach, M. [Deutsches Krebsforschungszentrum (DKFZ) Heidelberg, Abteilung Radiologie (E010), Heidelberg (Germany); Thoraxklinik Heidelberg, Abteilung Diagnostische und Interventionelle Radiologie, Heidelberg (Germany)

    2010-08-15

    Lung cancer staging according to the TNM system is based on morphological assessment of the primary cancer, lymph nodes and metastases. All aspects of this important oncological classification are measurable with MRI. Pulmonary nodules can be detected at the clinically relevant size of 4-5 mm in diameter. The extent of mediastinal, hilar and supraclavicular lymph node affection can be assessed at the same time. The predominant metastatic spread to the adrenal glands and spine can be detected in coronal orientation during dedicated MRI of the lungs. Search focused whole body MRI completes the staging. Various additional MR imaging techniques provide further functional and clinically relevant information during a single examination. In the oncological context the most important techniques are imaging of perfusion and tumor motion. Functional MRI of the lungs complements the pure staging and improves surgical approaches and radiotherapy planning. (orig.) [German] Das Staging des Lungenkarzinoms nach dem TNM-System basiert auf der morphologischen Einschaetzung des Primarius, der Lymphknoten und Metastasen. Alle Aspekte dieser onkologisch wichtigen Beurteilung lassen sich mit der MRT erfassen. Pulmonale Rundherde sind ab der klinisch relevanten Groesse von 4-5 mm Durchmesser sicher erkennbar. Die Groesse der mediastinalen, hilaeren und supraklavikulaeren Lymphknoten kann in einem Untersuchungsgang bestimmt werden. In der koronaren Schichtfuehrung der dedizierten MRT der Lunge werden die Bereiche der bevorzugten Metastasierung in Nebennieren und weite Teile der Wirbelsaeule miterfasst. Durch eine gezielte Ganzkoerper-MRT als Suchmethode wird der letzte Teil des Stagings erfuellt. Die MRT bietet vielfaeltige Moeglichkeiten, zusaetzliche funktionelle, klinisch relevante Informationen innerhalb einer Untersuchung zu erheben. Im onkologischen Kontext sind die Perfusionsbildgebung der Lunge und die Bewegungsabschaetzung der Tumoren am bedeutendsten. Die funktionelle MRT der

  13. Producing desulfurized biogas through removal of sulfate in the first-stage of a two-stage anaerobic digestion.

    Science.gov (United States)

    Yun, Yeo-Myeong; Sung, Shihwu; Shin, Hang-Sik; Han, Jong-In; Kim, Hyun-Woo; Kim, Dong-Hoon

    2017-05-01

    In the present work, a two-stage anaerobic digestion system (TSADS) was newly designed to produce biogas with a greatly reduced H2 S content. The role of first (sulfidogenic)-stage digester was not only acidogenesis but also sulfidogenesis (sulfate reduction to H2 S), which would minimize the input of H2 S-producing source in the followed second (methanogenic)-stage digester. For the coexistence of acidogens and sulfate reducing bacteria (SRB) in the sulfidogenic-stage digester, it was found that pH played a crucial role. The acidogenic activity was not affected within a pH range of 4.5-6.0, while it was important to maintain a pH at 5.5 to achieve a sulfate removal efficiency over 70%. The highest sulfate removal attained was 78% at a hydraulic retention time (HRT) of 5 h at pH 5.5 ± 0.1. The H2 S content in the biogas produced in the conventional single-stage digester (SSAD), used as a control, reached 1,650 ± 25 ppmv . In contrast, the biogas produced in the methanogenic-stage digester of the developed process had an H2 S content of 200 ± 15 ppmv . Microbial analysis, done by the next generation sequencing technique, clearly showed the changes in community under different operating conditions. Desulfovibrio bastinii (4.9%) played a key role in sulfate removal in the sulfidogenic-stage of the TSADS owing to its characteristics of a short doubling time and growth in an acidic environment. Biotechnol. Bioeng. 2017;114: 970-979. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  14. Staging of laser-plasma accelerators

    Energy Technology Data Exchange (ETDEWEB)

    Steinke, S., E-mail: ssteinke@lbl.gov; Tilborg, J. van; Benedetti, C.; Geddes, C. G. R.; Gonsalves, A. J.; Nakamura, K.; Schroeder, C. B.; Esarey, E. [Lawrence Berkeley National Laboratory, Berkeley, California 94720 (United States); Daniels, J. [Lawrence Berkeley National Laboratory, Berkeley, California 94720 (United States); Eindhoven University of Technology, PO Box 513, 5600MB Eindhoven (Netherlands); Swanson, K. K.; Shaw, B. H.; Leemans, W. P. [Lawrence Berkeley National Laboratory, Berkeley, California 94720 (United States); University of California, Berkeley, California 94720 (United States)

    2016-05-15

    We present results of an experiment where two laser-plasma-accelerator stages are coupled at a short distance by a plasma mirror. Stable electron beams from the first stage were used to longitudinally probe the dark-current-free, quasi-linear wakefield excited by the laser of the second stage. Changing the arrival time of the electron beam with respect to the second stage laser pulse allowed reconstruction of the temporal wakefield structure, determination of the plasma density, and inference of the length of the electron beam. The first stage electron beam could be focused by an active plasma lens to a spot size smaller than the transverse wake size at the entrance of the second stage. This permitted electron beam trapping, verified by a 100 MeV energy gain.

  15. Compact 6-DOF Stage for Optical Adjustments

    Science.gov (United States)

    Shafaat, Syed; Chang, Daniel

    2008-01-01

    The figure depicts selected aspects of a six-degree-of-freedom (6-DOF) stage for mechanical adjustment of an optical component. The six degrees of freedom are translations along the Cartesian axes (x, y, and z) and rotations about these axes (theta x, theta y, and theta z, respectively). Relative to prior such stages, this stage offers advantages of compactness, stability, and robustness, plus other advantages as described below. The stage was designed specifically as part of a laser velocimeter and altimeter in which light reflected by a distant object is collected by a Cassegrainian telescope and focused into a single-mode, polarization-maintaining optical fiber. The stage is used to position and orient the input end of the optical fiber with respect to the focal point of the telescope. Stages like this one can also be adapted for use in positioning and orienting other optical components, including lenses, prisms, apertures, and photodetectors.

  16. Pelvic organ prolapse symptoms in relation to POPQ, ordinal stages and ultrasound prolapse assessment.

    NARCIS (Netherlands)

    Kluivers, K.B.; Hendriks, J.C.M.; Shek, C.; Dietz, H.P.

    2008-01-01

    Adequate staging of pelvic organ prolapse is important in clinical practice and research. The ability of the POPQ, ordinal stages and ultrasound prolapse assessment were evaluated for their ability to discriminate between women with and without prolapse symptoms. The leading edge of the predominant

  17. Stage-specific survival of epithelial cancers in North-Holland/Flevoland, The Netherlands

    NARCIS (Netherlands)

    Visser, O.; Leeuwen, van F.E.

    2005-01-01

    While stage is the most important factor for determining cancer survival, population-based survival data according to stage are rarely presented. We present such data for a large population diagnosed with cancer in the area covered by the Amsterdam Cancer Registry for the period 1989-2001 (n=108,251

  18. Stage-specific survival of epithelial cancers in North-Holland/Flevoland, The Netherlands

    NARCIS (Netherlands)

    Visser, O.; Leeuwen, van F.E.

    2005-01-01

    While stage is the most important factor for determining cancer survival, population-based survival data according to stage are rarely presented. We present such data for a large population diagnosed with cancer in the area covered by the Amsterdam Cancer Registry for the period 1989-2001

  19. Remembering the Important Things: Semantic Importance in Stream Reasoning

    Energy Technology Data Exchange (ETDEWEB)

    Yan, Rui; Greaves, Mark T.; Smith, William P.; McGuinness, Deborah L.

    2016-11-04

    Reasoning and querying over data streams rely on the abil- ity to deliver a sequence of stream snapshots to the processing algo- rithms. These snapshots are typically provided using windows as views into streams and associated window management strategies. Generally, the goal of any window management strategy is to preserve the most im- portant data in the current window and preferentially evict the rest, so that the retained data can continue to be exploited. A simple timestamp- based strategy is rst-in-rst-out (FIFO), in which items are replaced in strict order of arrival. All timestamp-based strategies implicitly assume that a temporal ordering reliably re ects importance to the processing task at hand, and thus that window management using timestamps will maximize the ability of the processing algorithms to deliver accurate interpretations of the stream. In this work, we explore a general no- tion of semantic importance that can be used for window management for streams of RDF data using semantically-aware processing algorithms like deduction or semantic query. Semantic importance exploits the infor- mation carried in RDF and surrounding ontologies for ranking window data in terms of its likely contribution to the processing algorithms. We explore the general semantic categories of query contribution, prove- nance, and trustworthiness, as well as the contribution of domain-specic ontologies. We describe how these categories behave using several con- crete examples. Finally, we consider how a stream window management strategy based on semantic importance could improve overall processing performance, especially as available window sizes decrease.

  20. PERSONNEL TRAINING - AN IMPORTANT LINK OF IMPORT SUBSTITUTION

    Directory of Open Access Journals (Sweden)

    Trubilin A. I.

    2016-03-01

    Full Text Available Import substitution - a process at the level of the national economy, which is provided at the release of the necessary domestic consumer goods manufacturers forces, leading activities in the country. At present, Russian farmers have an incentive to carry out a largescale import substitution because of the food embargo on the West European suppliers of agricultural products. An important problem that accompanies the processes of import substitution in Russia is the lack of qualified personnel in a number of industries, as a prerequisite for the growth of agricultural production in Russia is full staffing agriculture. The article has identified the causes of insufficient practical training of graduates of agricultural universities. The role of Kuban State Agrarian University in the personnel matters of the village. Grounded following directions of improvement of training: the formation of the federal and regional forecasts provide human resources for the future of the village; the creation of organizations and municipalities comfortable social environment for young professionals; promotion of public – private partnership for the training of personnel for rural areas; improving infrastructure to support the system of financing higher education institutions; protection of the region's interest in defending the rights of agrarian university on training for other sectors of the economy in rural areas, except for agricultural commodity production; empowerment of the target form of training specialists; allocation of resources (possibly in the form of grants to prepare doctors to foreign training, access to foreign sources of scientific information, cooperation of universities to gain access to the Web of Science and Scopus' resources

  1. Experiments for Multi-Stage Processes

    DEFF Research Database (Denmark)

    Tyssedal, John; Kulahci, Murat

    2015-01-01

    Multi-stage processes are very common in both process and manufacturing industries. In this article we present a methodology for designing experiments for multi-stage processes. Typically in these situations the design is expected to involve many factors from different stages. To minimize...... the required number of experimental runs, we suggest using mirror image pairs of experiments at each stage following the first. As the design criterion, we consider their projectivity and mainly focus on projectivity 3 designs. We provide the methodology for generating these designs for processes with any...

  2. Cervical cancer: screening, diagnosis and staging.

    Science.gov (United States)

    Tsikouras, Panagiotis; Zervoudis, Stefanos; Manav, Bachar; Tomara, Eirini; Iatrakis, George; Romanidis, Constantinos; Bothou, Anastasia; Galazios, George

    2016-01-01

    Purpose: Despite the widespread screening programs, cervical cancer remains the third most common cancer in developing countries. Based on the implementation of cervical screening programs with the referred adoption of improved screening methods in cervical cytology with the knowledge of the important role of the human papilloma virus (HPV) it's incidence is decreased in the developed world. Even if cervical HPV infection is incredibly common, cervical cancer is relatively rare. Depending on the rarity of invasive disease and the improvement of detection of pre-cancerous lesions due to the participation in screening programs, the goal of screening is to detect the cervical lesions early in order to be treated before cancer is developed. In populations with many preventive screening programs, a decrease in cervical cancer mortality of 50-75% is mentioned over the past 50 years. The preventive examination of vagina and cervix smear, Pap test, and the HPV DNA test are remarkable diagnostic tools according to the American Cancer Association guidelines, in the investigation of asymptomatic women and in the follow up of women after the treatment of pre-invasive cervical cancer. The treatment of cervical cancer is based on the FIGO 2009 cervical cancer staging.

  3. Why geodiversity matters in valuing nature's stage.

    Science.gov (United States)

    Hjort, Jan; Gordon, John E; Gray, Murray; Hunter, Malcolm L

    2015-06-01

    Geodiversity--the variability of Earth's surface materials, forms, and physical processes-is an integral part of nature and crucial for sustaining ecosystems and their services. It provides the substrates, landform mosaics, and dynamic physical processes for habitat development and maintenance. By determining the heterogeneity of the physical environment in conjunction with climate interactions, geodiversity has a crucial influence on biodiversity across a wide range of scales. From a literature review, we identified the diverse values of geodiversity; examined examples of the dependencies of biodiversity on geodiversity at a site-specific scale (for geosites <1 km(2) in area); and evaluated various human-induced threats to geosites and geodiversity. We found that geosites are important to biodiversity because they often support rare or unique biota adapted to distinctive environmental conditions or create a diversity of microenvironments that enhance species richness. Conservation of geodiversity in the face of a range of threats is critical both for effective management of nature's stage and for its own particular values. This requires approaches to nature conservation that integrate climate, biodiversity, and geodiversity at all spatial scales. © 2015 Society for Conservation Biology.

  4. The Relative Importance of Health

    Science.gov (United States)

    Hsieh, Chang-Ming

    2008-01-01

    This article seeks to extend Michalos' [Social indicators research and health-related quality of life (QoL) research. "Social Indicators Research," 65, 27-72, 2004] discussion on bridging social indicators research and health-related QoL (HRQoL) research through an examination of (1) the relative importance of satisfaction with one's own health to…

  5. Importance of Effective Listening Infomercial

    Science.gov (United States)

    Johnson-Curiskis, Nanette

    2009-01-01

    This article details an activity intended for use in a course with a unit on effective listening, including listening courses, public speaking, and interpersonal communication. Students will explain the importance of effective and active listening for a target audience by producing an infomercial for a product or service which they design.

  6. The importance of board independence

    NARCIS (Netherlands)

    Zijl, N.J.M.

    2012-01-01

    Although the attributed importance of board independence is high, a clear definition of independence does not exist. Furthermore, the aim and consequences of independence are the subject of discussion and empirical evidence about the impact of independence is weak and disputable. Despite this lack o

  7. Importance of Depression in Diabetes.

    Science.gov (United States)

    Lustman, Patrick J.; Clouse, Ray E.; Anderson, Ryan J.

    Depression doubles the likelihood of comorbid depression, which presents as major depression in 11% and subsyndromal depression in 31% of patients with the medical illness. The course of depression is chronic, and afflicted patients suffer an average of one episode annually. Depression has unique importance in diabetes because of its association…

  8. The Relative Importance of Health

    Science.gov (United States)

    Hsieh, Chang-Ming

    2008-01-01

    This article seeks to extend Michalos' [Social indicators research and health-related quality of life (QoL) research. "Social Indicators Research," 65, 27-72, 2004] discussion on bridging social indicators research and health-related QoL (HRQoL) research through an examination of (1) the relative importance of satisfaction with one's own health to…

  9. The Importance of Interpersonal Relationships

    Science.gov (United States)

    Weber, Mark J.

    2007-01-01

    The goal of our lesson in this module is for you to become acquainted with the importance of es- tablishing and maintaining a shared vision of positive professional interpersonal relationship practices among all stakeholders on your campus. This module introduces the use of administrative tools designed to help you document and measure progress…

  10. The Importance of Critical Literacy

    Science.gov (United States)

    Janks, Hilary

    2012-01-01

    This paper is divided into three parts. It begins by making an argument for the ongoing importance of critical literacy at a moment when there are mutterings about its being passe. The second part of the paper formulates the argument with the use of illustrative texts. It concludes with examples of critical literacy activities that I argue, are…

  11. The Importance of Prior Knowledge.

    Science.gov (United States)

    Cleary, Linda Miller

    1989-01-01

    Recounts a college English teacher's experience of reading and rereading Noam Chomsky, building up a greater store of prior knowledge. Argues that Frank Smith provides a theory for the importance of prior knowledge and Chomsky's work provided a personal example with which to interpret and integrate that theory. (RS)

  12. The Importance of Prior Knowledge.

    Science.gov (United States)

    Cleary, Linda Miller

    1989-01-01

    Recounts a college English teacher's experience of reading and rereading Noam Chomsky, building up a greater store of prior knowledge. Argues that Frank Smith provides a theory for the importance of prior knowledge and Chomsky's work provided a personal example with which to interpret and integrate that theory. (RS)

  13. Writing: Importance, Development, and Instruction

    Science.gov (United States)

    Graham, Steve; Gillespie, Amy; McKeown, Debra

    2013-01-01

    In this article, we examine why writing is important, how it develops, and effective writing practices. We situate the 5 articles in this special issue of "Reading and Writing" in this literature, providing a context for the contribution of each paper.

  14. Writing: Importance, Development, and Instruction

    Science.gov (United States)

    Graham, Steve; Gillespie, Amy; McKeown, Debra

    2013-01-01

    In this article, we examine why writing is important, how it develops, and effective writing practices. We situate the 5 articles in this special issue of "Reading and Writing" in this literature, providing a context for the contribution of each paper.

  15. Application of Cervical Vertebral Maturation Stages Index in Orthodontics

    Directory of Open Access Journals (Sweden)

    Z.Dalili

    2005-02-01

    Full Text Available Evaluation of skeletal age and determination of growth status had important and special roie in orthodontic treatment planning (such as functional orthopedic treatment and orthognatic surgery and also in stability of it. There were several biologic indicators for the detection of the peak in mandibular growth. Due to the limitations of biological indicators application, idea of new indicators was seemed importantly. Cervical vertebral maturation (CVM method is one of them. At first the detection of the peak in mandibular growth was based on the analysis of the second through sixth cervical vertebrae in six developmental stages. But a few improvements of the original CVM analysis were still needed. In this method, the peak in mandibular growth was determined based on the analysis of the second through fourth cervical vertebrae in five developmental stages. This method is easy, applicable and more valid than hand-wrist analysis method.

  16. Ganglion sentinelle et sentibras: pour un "staging" axillaire sur mesure

    OpenAIRE

    2011-01-01

    The status of the axillary lymph nodes is one of the most important prognostic factors in women with early stage breast cancer. Histologic examination of removed lymph nodes is the most accurate method for assessing spread of disease to these nodes. Axillary lymph node dissection (ALND) remains the standard approach for women who have clinically palpable axillary nodes. The benefits of ALND include its impact on disease control (axillary recurrence and survival), its prognostic value, and its...

  17. Endobronchial Photoacoustic Microscopy for Staging of Lung Cancer

    Science.gov (United States)

    2016-08-01

    optical absorber which is important for PA imaging. To image the lymph node, the dye or absorber is necessary to generate the acoustic signals for...SUPPLEMENTARY NOTES Photoacoustic imaging, photoacoustic microscopy, lung cancer 14. ABSTRACT This research is aimed at developing a new endoscopic...imaging approach, called “photoacoustic microscopy (PAM)”, for lung cancer staging. The project will develop imaging hardware and conduct phantom

  18. Gastric atrophy, diagnosing and staging

    Institute of Scientific and Technical Information of China (English)

    Hala MT El-Zimaity

    2006-01-01

    H pylori is now accepted as the cause of gastritis and gastritis-associated diseases, such as duodenal ulcer,gastric ulcer, gastric carcinoma, and gastric MALT lymphoma. The natural history of H pylori gastritis includes inflammation progressing from the antrum into the adjacent corpus resulting in an atrophic front of advancing injury leading to a reduction in acid secretion and eventual loss of parietal cells and development of atrophy. Sub-typing intestinal metaplasia has no clinical value to the patient, the pathologist, or the endoscopist.The pattern, extent, and severity of atrophy, with or without intestinal metaplasia, is a far more important predictor than is intestinal metaplasia subtype. The challenge remains to identify a reliable marker that relates to pre-malignant potential.

  19. [Classification of human sleep stages based on EEG processing using hidden Markov models].

    Science.gov (United States)

    Doroshenkov, L G; Konyshev, V A; Selishchev, S V

    2007-01-01

    The goal of this work was to describe an automated system for classification of human sleep stages. Classification of sleep stages is an important problem of diagnosis and treatment of human sleep disorders. The developed classification method is based on calculation of characteristics of the main sleep rhythms. It uses hidden Markov models. The method is highly accurate and provides reliable identification of the main stages of sleep. The results of automatic classification are in good agreement with the results of sleep stage identification performed by an expert somnologist using Rechtschaffen and Kales rules. This substantiates the applicability of the developed classification system to clinical diagnosis.

  20. One-stage and two-stage penile buccal mucosa urethroplasty

    Directory of Open Access Journals (Sweden)

    G. Barbagli

    2016-03-01

    Full Text Available The paper provides the reader with the detailed description of current techniques of one-stage and two-stage penile buccal mucosa urethroplasty. The paper provides the reader with the preoperative patient evaluation paying attention to the use of diagnostic tools. The one-stage penile urethroplasty using buccal mucosa graft with the application of glue is preliminary showed and discussed. Two-stage penile urethroplasty is then reported. A detailed description of first-stage urethroplasty according Johanson technique is reported. A second-stage urethroplasty using buccal mucosa graft and glue is presented. Finally postoperative course and follow-up are addressed.

  1. A Staged Reading of the Play: No No Nobel

    Science.gov (United States)

    A Staged Reading of the Play: No No Nobel -- In Biology, what discovery is considered the most important breakthrough of the 20th century? In Chemistry, what pattern development enabled chemists and physicists to understand the nature of and ultimately the atomic physics of the elements? In Physics, what experiment and theory in nuclear physics led to the most important journalistic story of the 20th century? In Cosmology, what theory was developed that enabled the understanding of the now named Big Bang theory and the evolution of the universe? In Science Education, what graduate student made a most important observation and ultimately the identification of a remnant of a supernova explosion? Join us for a dramatic staged reading of No No Nobel and find out what unifies all the above questions. The playwright is the science historian David Cassidy and the staged reading is performed by the Baltimore Improv Group www.bigimprov.org . After the performance, the playwright, the director Mike Harris and the actors will be available for a talk-back audience discussion. Produced by Brian Schwartz, Brooklyn College and the Graduate Center of the City University of New York

  2. Correlation of CliniCal data, anatomiCal site and disease stage in ...

    African Journals Online (AJOL)

    2008-06-01

    Jun 1, 2008 ... Objective: to evaluate the colorectal cancer clinical data with respect to the anatomical location and stage of ... important prognostic factor in crc, early symptom investigation and .... colorectal and lung cancer. Brit. J. Cancer.

  3. Are All Pixels Equally Important?

    CERN Document Server

    CERN. Geneva

    2015-01-01

    When we look at our environment, we primarily pay attention to visually distinctive objects. We refer to these objects as visually important or salient. For efficient visual processing, the human visual system identifies salients objects and dedicates most of its processing resources to them. An analogous resource allocation can be performed by salient-object detection algorithms, which identify objects of interest in an image. Consequently, thanks to salient-object detection, complex visual computing operations can focus on the important parts of the visual data and can save time and resources. About the speaker Dr. Gokhan Yildirim is a research assistant in the School of Computer and Communication Sciences (IC) at the École Polytechnique Fédérale de Lausanne (EPFL). His research interests include image understanding, multimedia, pattern recognition, machine learning, salient-object detection on images & videos and its applications on image proces...

  4. Progress in understanding the importance of coastal wetland nursery habitat to Great Lakes fisheries support

    Science.gov (United States)

    Great Lakes coastal wetlands provide important habitat for Great Lakes fishes of all life stages. A literature review of ichthyoplankton surveys conducted in Great Lakes coastal wetlands found at least 82 species reported to be captured during the larval stage. Twenty of those sp...

  5. Bioavailability & Bioequivalence Studies ? Pharmaceutical Importance

    OpenAIRE

    Pratibha Muntha

    2015-01-01

    Pharmacokinetics has now emerged as an important part of drug development especially in the development of new drugs. The combined studies of Pharmacodynamics and pharmacokinetics present a thorough understanding on how the drug affects the body and how the body affects the drug.Bioavailability is the study of the rate and extent to which the active ingredient is absorbed from a dosage form and it is available at the required action site. Bioequivalence is that the...

  6. The Most Important of All

    Institute of Scientific and Technical Information of China (English)

    AvonneMclaughlin; 库蒂

    2002-01-01

    Jeremy’s bedroom furniture (家具) was having an argument. “I am definitely the most important,” said the chest of drawers (五斗柜).“Jeremy always looks in my bottom drawer for his socks. He looks in my middle drawer for his shirts and my top drawer for his jeans (牛仔裤). If it were not for me, he would not be able to find his clothes.”

  7. The strategic importance of data.

    Science.gov (United States)

    Glaser, John; Markell, Peter; Stone, John

    2010-02-01

    Two factors--accountability for care and an increased adoption of interoperable electronic health records (EHRs)--will significantly increase the importance of data for healthcare organizations. These factors have significant data ramifications in four areas: payment reform, data use policies, IT strategy, and data management. As data become a strategic asset, healthcare finance executives will need to become significant contributors to their organizations' EHR initiatives and data management strategies.

  8. ECOPHARMACOVIGILANCE: ITS IMPORTANCE AND CHALLENGES

    OpenAIRE

    Dr. Bhavana Srivastava

    2014-01-01

    Active pharmaceutical ingredients represent a group of emerging environmental contamination. Even in trace amounts, they are of great concern due to then continuous introduction into the environment, their impact an ecosystem and human and vetenery health is of great importance. This has given birth to the science of Ecopharmacovigilance (EPV). It aims to ensure that significant environmental issues associated with pharmaceuticals in the environment are identified and managed appropriately. ...

  9. Marketing importance of body image

    OpenAIRE

    Novák, Erik

    2013-01-01

    In China, applicants for flight attendant job voluntarily visit the hospital to break the tibia bone, into which is inserted gradually the expanding facility to ultimately adds the necessary centimeters to them to have chase to become flight attendants. The physical appearance seems to play in our lives increasingly greater role. How far we can go and what we can do to make us look better? Bachelor's work "The Marekting Importance of Body Image" introduces the reader with a theoretical part o...

  10. Uniqueness is Important in Competition

    Institute of Scientific and Technical Information of China (English)

    FENG Ai-Xia; XV Xiu-Lian; HE Da-Ren

    2009-01-01

    We propose a quantitative network description on the function of uniqueness in a competition system. Two statistical parameters, competition ability and uniqueness are defined, and their relationship in ordinary cases is analytically discussed. The competition between Chinese regional universities is taken as an example. The empirical investigation results show that the uniqueness of a university is really important in competition. Also,uniqueness is very helpful in the promotion of the university overall quality.

  11. Imported malaria in Okayama prefecture

    OpenAIRE

    安治, 敏樹; 頓宮, 廉正; 頼, 俊雄; 何, 黎星; 下野, 國夫; 稲臣, 成一; 村主,節雄; 塩田, 哲也; 桜井, 浩一

    1981-01-01

    Two cases of imported malaria which occurred in Okayama prefecture are reported. One was infected with Plasmodium vivax in India, the other with P. falciparum at Nigeria, Africa. The efficacy of some antimalarial drugs in these cases is discussed. One patient was infected with P. falciparum, despite taking the medicine Daraprim® regularly. The efficacy of Daraprim® for suppressive cure in Nigeria is doutful. The therapy of chloroquine-resistance tropical malaria is also discussed.

  12. [Forensic importance of premature craniosynostosis].

    Science.gov (United States)

    Fehlow, P

    1991-01-01

    In agreement with Canabis craniosynostosis as a little known organic partial factor of sociopathy is demonstrated. A psychic syndrome of the frontal lobe with increased susceptibility in environmental damages is assumed to be basic disorder. In the criminals of the material sexual offenders were preponderating. Associated craniofacial dysplasias are a risk for psychic maldevelopment. The importance of premature craniosynostocis as a biological risk factor, incidence, diagnostic, indication for an operation, also in the meaning of a neurosurgical "Konflikttherapie" (cosmetical indication) are discussed.

  13. IMPORTANCE OF HYDRATION IN SPORTS

    Directory of Open Access Journals (Sweden)

    Goran Vasić

    2008-08-01

    Full Text Available Importance of hydration is detrmined by importance of functions of water in the human organism: i.e. regulation of body temperature, transport, excretion of waste materials through urine, digestion of food which is facilititated by saliva and gastric juices, maintenance of flexibility of organs and tissues About 60 % body mass of an adult person (males: 61 %, females: 54 % is made up of water. Water content of a newly born baby reaches 77 %, and it is up to 50 % in adults. It is very important for sportsmen to provide adequate hydration during and after the time of bodily activities. A symptom of water shortage is thirst. However, thirst is a late response of an organism and it occurs when dehydration has already taken place. Minimum in take of fluids in humans should range between one-and-half to two liters. It has been known for a long time that there is no success in sport without proper hydration in a sportsman.

  14. Late-Stage Reservoir Formation Effect and Its Dynamic Mechanisms in Complex Superimposed Basins

    Institute of Scientific and Technical Information of China (English)

    KANG Dejiang; PANG Xiongqi; KUANG Jun; LUO Xiaorong; PANG Hong; LEI Lei

    2010-01-01

    Complex superimposed basins exhibit multi-stage tectonic events and multi-stage reservoir formation; hydrocarbon reservoirs formed in the early stage have generally late-stage genesis characteristics after undergoing adjustment,reconstruction and destruction of later-stage multiple tectonic events.In this paper,this phenomenon is called the late-stage reservoir formation effect.The late-stage reservoir formation effect is a basic feature of oil and gas-forming reservoirs in complex superimposed basins,revealing not only multi-stage character,relevance and complexity of oil and gas-forming reservoirs in superimposed basins but also the importance of late-stage reservoir formation.Late-stage reservoir formation is not a basic feature of off and gas forming reservoir in superimposed basins.Multi-stage reservoir formation only characterizes one aspect of oil and gas-forming reservoir in superimposed basins and does not represent fully the complexity of oil and gas-forming reservoir in superimposed basins.We suggest using"late-stage reservoir formation effect"to replace the"late-stage reservoir formation"concept to guide the exploration of complex reservoirs in superimposed basins.Under current geologic conditions,the late-stage reservoir formation effect is represented mainly by four basic forms:phase transformation,scale reconstruction,component variation and trap adjustment.The late-stage reservoir formation effect is produced by two kinds of geologic processes:first,the off and gas retention function of various geologic thresholds(hydrocarbon expulsion threshold,hydrocarbon migration threshold,and hydrocarbon accumulating threshold)causes the actual time of oil and gas reservoir formation to be later than the time of generation of large amounts of hydrocarbon in a conventional sense,producing the late-stage reservoir formation effect; second,multiple types of tectonic events(continuously strong reconstruction,early-stage strong reconstruction,middle-stage strong

  15. Stages of Small-Group Development Revisited

    Science.gov (United States)

    Tuckman, Bruce W.; Jensen, Mary Ann C.

    1977-01-01

    This review examines published research on small-group development done in the last ten years that would constitute an empirical test of Tuckman's hypothesis that groups go through the stages of "forming,""storming,""norming," and "performing." A fifth stage, "adjourning," was added to the…

  16. The Stages of Mailed Questionnaire Returning Behavior.

    Science.gov (United States)

    Lockhart, Daniel C.

    1984-01-01

    Six stages are hypothesized that define the behavior of returning mailed questionnaires: receiving the questionnaire, opening the mail, forming an overall impression, answering the questions, returning the questionnaire, and dealing with nonrespondents. The researcher must provide incentives at each stage if potential respondents are to complete a…

  17. Indeterminate Pulmonary Nodules at Colorectal Cancer Staging

    DEFF Research Database (Denmark)

    Nordholm-Carstensen, Andreas; Wille-Jørgensen, Peer A; Jorgensen, Lars N

    2013-01-01

    This study aimed to estimate the prevalence of indeterminate pulmonary nodules and specific radiological and clinical characteristics that predict malignancy of these at initial staging chest computed tomography (CT) in patients with colorectal cancer. A considerable number of indeterminate...... pulmonary nodules, which cannot readily be classified as either benign or malignant, are detected at initial staging chest CT in colorectal cancer patients....

  18. [Klatskin tumors: rational diagnostics and staging].

    Science.gov (United States)

    Denzer, U W; Rösch, T

    2012-03-01

    Klatskin tumors continue to be a challenge for diagnostic assessment and staging due to their longitudinal tumor growth along the perihilar bile ducts. Therefore the rate of non-resectable tumors remains relatively stable despite modern imaging and endoscopic techniques. This article reviews the current diagnostic methods for preoperative staging and the significance for predicting resectability.

  19. Developmental Stages in the Conceptualization of Marriage

    Science.gov (United States)

    Tamashiro, Roy T.

    1978-01-01

    "Marriage" is treated as a mental concept that evolves in a developmental sequence of four qualitatively distinct stages: Magical, Idealized Conventional, Individualistic, and Affirmational. Each stage is illustrated with excerpts from Ingmar Bergman's Scenes From a Marriage. Some applications for marriage counselors are suggested. (Author)

  20. The construction of two-stage tests

    NARCIS (Netherlands)

    Adema, Jos J.

    1988-01-01

    Although two-stage testing is not the most efficient form of adaptive testing, it has some advantages. In this paper, linear programming models are given for the construction of two-stage tests. In these models, practical constraints with respect to, among other things, test composition, administrat

  1. The Sixth Stage of Moral Development

    Science.gov (United States)

    Morelli, E. A.

    1978-01-01

    This assessment of L. Kohlberg's theory of moral development is a dialectical critique focusing on his claim that the sixth stage of moral development is morally adequate, specifically, that it is both comprehensive and fully equilibrated. Includes a brief account of B. J. Lonergan's dialectical method and an analysis of the sixth stage of…

  2. Transesophageal Ultrasonography for Lung Cancer Staging

    DEFF Research Database (Denmark)

    Konge, Lars; Annema, Jouke; Vilmann, Peter

    2013-01-01

    Accurate mediastinal nodal staging is essential for patients with resectable non-small-cell lung cancer and is achieved by combined endobronchial ultrasound and transesophageal endoscopic ultrasound (EUS). Training requirements for EUS-guided fine-needle aspiration (FNA) for lung cancer staging...

  3. Second-Stage Music Teachers' Professional Identities

    Science.gov (United States)

    Draves, Tami J.

    2013-01-01

    The purpose of this case study research was to explore the professional identities of second-stage music teachers, or those in years 4-10 of teaching, focusing primarily on how their identities were sustained or neglected. Participants were two second stage music educators teaching in middle school (grades 6-8) music classrooms and taught…

  4. Transesophageal Ultrasonography for Lung Cancer Staging

    DEFF Research Database (Denmark)

    Konge, Lars; Annema, Jouke; Vilmann, Peter

    2013-01-01

    Accurate mediastinal nodal staging is essential for patients with resectable non-small-cell lung cancer and is achieved by combined endobronchial ultrasound and transesophageal endoscopic ultrasound (EUS). Training requirements for EUS-guided fine-needle aspiration (FNA) for lung cancer staging...

  5. Dislocation generation during early stage sintering.

    Science.gov (United States)

    Sheehan, J. E.; Lenel, F. V.; Ansell, G. S.

    1973-01-01

    Discussion of the effects of capillarity-induced stresses on dislocations during early stage sintering. A special version of Hirth's (1963) theoretical calculation procedures modified to describe dislocation nucleation on planes meeting the sintering body's neck surface obliquely is shown to predict plastic flow at stress levels know to exist between micron size metal particles in the early stages of sintering.

  6. TNM staging and classification (familial and nonfamilial of breast cancer in Jordanian females

    Directory of Open Access Journals (Sweden)

    M F Atoum

    2010-01-01

    Full Text Available Purpose : Staging of breast tumor has important implications for treatment and prognosis. This study aims at pinpointing the frequency of each stage among familial and nonfamilial breast cancers. Materials and Methods : Ninety-nine Jordanian females diagnosed with familial and nonfamilial breast cancer between 2000 and 2002 were enrolled in this study All breast cancer cases were staged according to the TNM classification into in situ, early invasive, advanced invasive and metastatic. Results : Forty-three cases were familial breast cancer and 56 were nonfamilial. One female breast cancer was diagnosed with ductal carcinoma in situ (DCIS cancer. Fifty cases were diagnosed in early stages of invasive breast cancer, of which 31 cases were familial, 29 cases were classified as advanced invasive, where 21 cases were nonfamilial and 19 cases were metastatic stage of breast cancer, with 16 nonfamilial cases. Stage 2b was the most common stage of early invasive cases and represented 48% of the early stage of breast cancer. On the other hand, among cases diagnosed with advanced invasive breast cancer, stage 3a was the most common stage and represented 89.6% of the advanced stage. Interestingly, all cases of stage 3a belonged to TNM stages of T2N2M0 and T3N1M0. The tumor size in all cases of Jordanian females diagnosed with advanced invasive breast cancer exceeded 2 cm in size due to selection bias from symptomatic women in our study. Conclusion : The incidence of nonfamilial breast cancer was slightly higher than that of the familial type amongst studied the Jordanian females studied. The early invasive stage of breast cancer was more common in the familial while the advanced invasive and metastatic breast cancer cases were encountered more often in the nonfamilial type. Our study was based on a small sample and symptomatic women. Therefore, more research with larger population samples is needed to confirm this conclusion.

  7. Prevalence, predictors, and survival in pulmonary hypertension related to end-stage chronic obstructive pulmonary disease

    DEFF Research Database (Denmark)

    Andersen, Kasper Hasseriis; Iversen, Martin; Kjaergaard, Jesper;

    2012-01-01

    The prevalence, prognostic importance, and factors that predict the presence and degree of pulmonary hypertension (PH) diagnosed with right heart catheterization (RHC) in patients with end-stage chronic obstructive pulmonary disease (COPD) remain unclear.......The prevalence, prognostic importance, and factors that predict the presence and degree of pulmonary hypertension (PH) diagnosed with right heart catheterization (RHC) in patients with end-stage chronic obstructive pulmonary disease (COPD) remain unclear....

  8. Management of Low-Stage Testicular Seminoma.

    Science.gov (United States)

    Pearce, Shane M; Liauw, Stanley L; Eggener, Scott E

    2015-08-01

    Management of testicular seminoma has benefited from numerous advances in imaging, radiotherapy, and chemotherapy over the last 50 years leading to nearly 100% disease-specific survival for low-stage seminoma. This article examines the evaluation and management of low-stage testicular seminoma, which includes clinical stage I and IIA disease. Excellent outcomes for stage I seminoma are achieved with active surveillance, adjuvant radiotherapy, and adjuvant single-agent carboplatin. Current areas of research focus on optimizing surveillance regimens and minimizing the morbidity and long-term complications of adjuvant treatment. Radiotherapy continues to be the primary treatment option for patients with clinical stage IIa disease. Copyright © 2015 Elsevier Inc. All rights reserved.

  9. [Hypospadias--one-stage repair].

    Science.gov (United States)

    Ionescu, S; Andrei, B; Tîrlea, S; Amăriuţei, O

    2012-01-01

    The tubularised incised plate (TIP) is a common surgical technique used in the treatment of hypospadias. The study includes 52 urethroplasties, performed between 2007-2010. We performed Mathieu urethroplasty in 12% of the cases, Duplay urethroplasy in 88% of the cases and we used the Snoodgrass technique in 82% of the cases. The hospital stay varied between 3-8 days after surgery. We included in the study 32 patients with distal penile hypospadias, 8 with proximal hypospadias and 12 with midshaft hypospadias. To prevent fistula formation it is important to perform well sealed sutures, to interpose subcutaneous tissue between the urethroplasty and the cutaneous sutures, not to overlap the urethral and cutaneous sutures. The incidence of urethral fistula after the Duplay procedure was higher then after the Mathieu procedure, but the cases operated by the Duplay technique were manier and more difficult. The complications were more frequent in the cases with proximal hypospadias than in the cases with distal hypospadias, as well as the reintervention rate but not related to the surgical techniques. We present elements of diagnostic, embriology and etiopathogeny of hypospadias.

  10. Selectivity in associative learning: A cognitive stage framework for blocking and cue competition phenomena

    Directory of Open Access Journals (Sweden)

    Yannick eBoddez

    2014-11-01

    Full Text Available Blocking is the most important phenomenon in the history of associative learning theory: For over 40 years, blocking has inspired a whole generation of learning models. Blocking is part of a family of effects that are typically termed cue competition effects. Common amongst all cue competition effects is that a cue-outcome relation is poorly learned or poorly expressed because the cue is trained in the presence of an alternative predictor or cause of the outcome. We provide an overview of the cognitive processes involved in cue competition effects in humans and propose a stage framework that brings these processes together. The framework contends that the behavioral display of cue competition is cognitively construed following three stages that include (1 an encoding stage, (2 a retention stage, and (3 a performance stage. We argue that the stage framework supports a comprehensive understanding of cue competition effects.

  11. Buying Local or Imported Goods?

    DEFF Research Database (Denmark)

    Ayob, Abu H.; Hussain, Wan Mohd Hirwani Wan

    2016-01-01

    This study attempts to profile non-income consumers by examining their decisions to buy local or imported products. Hypotheses were drawn from discussions on the comparative advantages of advanced and developing countries, as well as the effects of a product’s country-of-origin on customers......’ purchasing decisions. Data was collected on 296 university students in Malaysia and analyzed through probit regression analysis. The findings reveal that foreign products from advanced countries are preferred by male students because of the superior quality and brand image. On the other hand, family members...

  12. PFGE: importance in food quality.

    Science.gov (United States)

    Vernile, Anna; Giammanco, Giovanni; Massa, Salvatore

    2009-11-01

    In late 19 century, great interest has arisen for food quality. This is referred as absence of pathogens in food (safety for consumers) and as nutritional quality of food (organoleptic characteristics). Pulsed-field gel electrophoresis (PFGE) is, among the molecular techniques developed in the last years, one of the most reliable, discriminative and reproducible technique. It can be used in clinical field for the identification of pathogens and the origin of outbreaks, and in food microbiology for the identification of pathogens (food borne disease surveillance) or of microorganisms responsible for the organoleptic characteristics of food. The present article shows some useful patents related to PFGE and importance in food quality.

  13. Imported submicroscopic malaria in Madrid

    Directory of Open Access Journals (Sweden)

    Ramírez-Olivencia Germán

    2012-09-01

    Full Text Available Abstract Background Submicroscopic malaria (SMM can be defined as low-density infections of Plasmodium that are unlikely to be detected by conventional microscopy. Such submicroscopic infections only occasionally cause acute disease, but they are capable of infecting mosquitoes and contributing to transmission. This entity is frequent in endemic countries; however, little is known about imported SMM. The goals of this study were two-fold: a to know the frequency of imported SMM, and b to describe epidemiological, laboratorial and clinical features of imported SMM. Methods A retrospective study based on review of medical records was performed. The study population consisted of patients older than 15 years attended at the Tropical Medicine Unit of Hospital Carlos III, between January 1, 2002 and December 31, 2007. Routinely detection techniques for Plasmodium included Field staining and microscopic examination through thick and thin blood smear. A semi-nested multiplex malaria PCR was used to diagnose or to confirm cases with low parasitaemia. Results SMM was diagnosed in 104 cases, representing 35.5% of all malaria cases. Mean age (IC95% was 40.38 years (37.41-43.34, and sex distribution was similar. Most cases were in immigrants, but some cases were found in travellers. Equatorial Guinea was the main country where infection was acquired (81.7%. Symptoms were present only in 28.8% of all SMM cases, mainly asthenia (73.3% of symptomatic patients, fever (60% and arthromialgias (53.3%. The associated laboratory abnormalities were anaemia (27.9%, leukopaenia (15.4% and thrombopaenia (15.4%. Co-morbidity was described in 75 cases (72.1%. Conclusions Results from this study suggest that imported SMM should be considered in some patients attended at Tropical Medicine Units. Although it is usually asymptomatic, it may be responsible of fever, or laboratory abnormalities in patients coming from endemic areas. The possibility of transmission in SMM has

  14. Importance of entomology in veterinary forensics

    Directory of Open Access Journals (Sweden)

    Aleksić Jelena

    2008-01-01

    Full Text Available Entomological evidence is legal evidence in the form of insects or related artropodes, and a field of their study in the aim of medicocriminal applications and veterinary-medical forensic cases is forensic entomology. The most obvious and widely present fauna on the animal and human corpse in early stages of the decomposition process are insect larvae that use the corps as an important food source. The insects found on the corpse represent a significant source of information for determining the time of death, which is an evaluation of the post-morted interval. Additionally, by comparing fauna around the body with fauna found on the body one can obtain information if the corpse was moved after death. Often, insects found on the body point out that infestation by larvae started before death. That implicates animal abuse and defines its duration. Based on these elements, a forensic doctor can deduce which level of abuse is in question. Entomology is an expanding field and the more cases are being shown and the more researchers are being taught how to use insects as a way of proving responsibility, the more it will develop. It is becoming more common for entomological evidence to be case-breaking in the determination of post mortem intervals, in both early and late decomposition phase.

  15. Tools for Reactive Distillation Column Design: Graphical and Stage-to-Stage Computation Methods

    DEFF Research Database (Denmark)

    Sanchez Daza, O.; Cisneros, Eduardo Salvador P.; Hostrup, Martin

    2001-01-01

    Based on the element mass balance concept, a graphical design method and a stage-to-stage multicomponent design method for reactive distillation columns have been developed. For distillation columns comprising reactive and non-reactive stages, a simple design strategy based on reactive and non......-reactive bubble point calculations is proposed. This strategy tracks the conversion and temperature between the feed and the end stages of the column. An illustrative example highlights the verification of the design strategy through rigorous simulation....

  16. Stage of urinary bladder cancer at first presentation

    Directory of Open Access Journals (Sweden)

    Al-Bazzaz Pishtewan

    2009-01-01

    Full Text Available The stage of urinary bladder cancer is an important factor in determining prognosis of the disease. This prospective study was performed to determine the stage of bladder cancer at first presentation at the Rizgary Hospital in the Erbil governorate in Iraqi Kurdistan. We evaluated 72 patients with bladder cancer. The grades and stages of bladder cancer of these patients were determined through physical examination and investigations. We found that 47.2% of patients had superficial cancer, 19.4% had tumor with invasion into the lamina propria and 30.6% of patients had tumor with invasion to muscle wall. Regional or distant metastases were found in 2.8% of patients. Well differentiated tumor was seen in 44.4% of the patients, moderately differentiated tumor was found in 38.9% and poorly differentiated tumor was found in 16.7% of the patients. Our study suggests that bladder cancer is diagnosed at a relatively early stage in the Erbil governorate. However, the situation can be further improved by adopting proper screening programs and performing appropriate investigations.

  17. Films of bacteria at interfaces: three stages of behaviour.

    Science.gov (United States)

    Vaccari, Liana; Allan, Daniel B; Sharifi-Mood, Nima; Singh, Aayush R; Leheny, Robert L; Stebe, Kathleen J

    2015-08-14

    We report an investigation of the formation of films by bacteria at an oil-water interface using a combination of particle tracking and pendant drop elastometry. The films display a remarkably varied series of dynamical and mechanical properties as they evolve over the course of minutes to hours following the creation of an initially pristine interface. At the earliest stage of formation, which we interrogate using dispersions of colloidal probes, the interface is populated with motile bacteria. Interactions with the bacteria dominate the colloidal motion, and the interface displays canonical features of active matter in a quasi-two-dimensional context. This active stage gives way to a viscoelastic transition, presumably driven by the accumulation at the interface of polysaccharides and surfactants produced by the bacteria, which instill the interface with the hallmarks of soft glassy rheology that we characterize with microrheology. Eventually, the viscoelastic film becomes fully elastic with the capability to support wrinkling upon compression, and we investigate this final stage with the pendant drop measurements. We characterize quantitatively the dynamic and mechanical properties of the films during each of these three stages - active, viscoelastic, and elastic - and comment on their possible significance for the interfacial bacterial colony. This work also brings to the forefront the important role that interfacial mechanics may play in bacterial suspensions with free surfaces.

  18. Associational Patterns of Scavenger Beetles to Decomposition Stages.

    Science.gov (United States)

    Zanetti, Noelia I; Visciarelli, Elena C; Centeno, Nestor D

    2015-07-01

    Beetles associated with carrion play an important role in recycling organic matter in an ecosystem. Four experiments on decomposition, one per season, were conducted in a semirural area in Bahía Blanca, Argentina. Melyridae are reported for the first time of forensic interest. Apart from adults and larvae of Scarabaeidae, thirteen species and two genera of other coleopteran families are new forensic records in Argentina. Diversity, abundance, and species composition of beetles showed differences between stages and seasons. Our results differed from other studies conducted in temperate regions. Four guilds and succession patterns were established in relation to decomposition stages and seasons. Dermestidae (necrophages) predominated in winter during the decomposition process; Staphylinidae (necrophiles) in Fresh and Bloat stages during spring, summer, and autumn; and Histeridae (necrophiles) and Cleridae (omnivores) in the following stages during those seasons. Finally, coleopteran activity, diversity and abundance, and decomposition rate change with biogeoclimatic characteristics, which is of significance in forensics. © 2015 American Academy of Forensic Sciences.

  19. The importance of being informed

    Science.gov (United States)

    Draganova, Tamara

    2013-04-01

    "Science needs a lot of inspiration and that is why it is very important to draw the students` inspiration because it is the inspiration that is the future of science." For 10 years on students, teachers, parents and citizens harmonize knowledge and skills, competencies and energy, renewable ideas and shared experience on the topic "Climate change" at our High School of Humanitarian "St. st. Cyril and Methodius". During the last 3 years we have been doing our utmost to encourage the students from our school to participate actively in different eco projects such as: 8 workshops and 2 conferences, 63 multimedia lessons in ecology, geography, world and personality; 15 interactive art lessons through the Forum-theatre, 7 photo exhibitions and 29 exhibitions on the topic "The Archives of the Planet Speak", 5 roundtable workshops, 19 eco-races, 7 scenarios of decision taking, 12 open lessons, 26 discussions, 5 scientific lectures given by professors from V. Tarnovo University, Department Geography, 9 questionnaires, 17 practical lessons and experiments held in the classroom, 13 training and 11 ecological campaigns named - "It depends on You", "Striped Rug - Colourful Beans", "Let`s Plant Life", "Saving Energy between Nations", "Save Today to Have Tomorrow", "Grey Is Not Fashionable" etc. Numerous meetings were held with representatives of NGOs, the Regional Inspectorate of Education, the Regional Inspectorate of Environment and Water Safety, V. Tarnovo University, Department Geography, V. Tarnovo Municipality and other communities. Students and university students were organized around the core activity of renewable energy sources, presenting scientific and creative activities such as models, presentations, poems, essays, drawing posters and more. Students under the guidance of a teacher in geography studied history, current treatment processes and phenomena, the signs of expression, the similarities and differences between different parts of the country and other parts

  20. Stages of dietary change among nationally-representative samples of adults in the European Union.

    Science.gov (United States)

    de Graaf, C; Van der Gaag, M; Kafatos, A; Lennernas, M; Kearney, J M

    1997-06-01

    To investigate the distribution across the different stages of change for each of the 15 participating European countries, and the effect of socio-demographic variables such as sex and education on this distribution. Also to assess the relationships between stages of change and influences of food choice, and other variables. A cross-sectional study in which quota-controlled, nationally-representative samples of approximately 1000 adults from each country completed a face-to-face interview-assisted questionnaire. The survey was conducted between October 1995 and February 1996 in the 15 member states of the European Union. 14331 subjects (aged 15 y upwards) completed the questionnaire. Data were weighted by population size for each country and by sex, age and regional distribution within each member state. Subjects were divided into five different categories according to their attitudes towards 'changing their eating habits in order to eat healthier': (1) Precontemplation; do not consider any changes, (2) Contemplation; consider changes, (3) Decision; make plans to change, (4) Action; carry out the changes, and (5) Maintenance; maintained changes for more than six months. 52% of the subjects were in the precontemplation stage, whereas 31% of the subjects were in the maintenance stage. Two, one, and seven percent of subjects were in the contemplation, decision and action stage, respectively. In the Mediterranean countries, and in Germany, there were more people (55-64%) in the precontemplation stage, whereas in the Scandinavian countries there were less people in precontemplation stage (20-38%). The opposite was true for the maintenance stage, whereas women and people with a higher education level tended to be more in the maintenance stage. With respect to influence on food choice, subjects in precontemplation stage found that taste was more important, whereas people in maintenance stage found that health was more important. The stages of change model makes a useful

  1. Multi-Stage Programs are Generalized Arrows

    CERN Document Server

    Megacz, Adam

    2010-01-01

    The lambda calculus, subject to typing restrictions, provides a syn- tax for the internal language of cartesian closed categories. This paper establishes a parallel result: staging annotations, subject to named level restrictions, provide a syntax for the internal language of Freyd categories, which are known to be in one-to-one correspondence with Arrows. The connection is made by interpreting multi-stage type systems as indexed functors from polynomial categories to their reindexings (Definitions 15 and 16). This result applies only to multi-stage languages which are (1) homogeneous, (2) allow cross-stage persistence and (3) place no restrictions on the use of structural rules in typing derivations. Removing these restrictions and repeating the construction yields generalized arrows, of which Arrows are a particular case. A translation from well-typed multi-stage programs to single-stage GArrow terms is provided. The translation is defined by induction on the structure of the proof that the multi-stage prog...

  2. Observing river stages using unmanned aerial vehicles

    Science.gov (United States)

    Niedzielski, Tomasz; Witek, Matylda; Spallek, Waldemar

    2016-08-01

    We elaborated a new method for observing water surface areas and river stages using unmanned aerial vehicles (UAVs). It is based on processing multitemporal five orthophotomaps produced from the UAV-taken visible light images of nine sites of the river, acquired with a sufficient overlap in each part. Water surface areas are calculated in the first place, and subsequently expressed as fractions of total areas of water-covered terrain at a given site of the river recorded on five dates. The logarithms of the fractions are later calculated, producing five samples, each consisted of nine elements. In order to detect statistically significant increments of water surface areas between two orthophotomaps, we apply the asymptotic and bootstrapped versions of the Student's t test, preceded by other tests that aim to check model assumptions. The procedure is applied to five orthophotomaps covering nine sites of the Ścinawka river (south-western (SW) Poland). The data have been acquired during the experimental campaign, at which flight settings were kept unchanged over nearly 3 years (2012-2014). We have found that it is possible to detect transitions between water surface areas associated with all characteristic water levels (low, mean, intermediate and high stages). In addition, we infer that the identified transitions hold for characteristic river stages as well. In the experiment we detected all increments of water level: (1) from low stages to mean, intermediate and high stages; (2) from mean stages to intermediate and high stages; and (3) from intermediate stages to high stages. Potential applications of the elaborated method include verification of hydrodynamic models and the associated predictions of high flows as well as monitoring water levels of rivers in ungauged basins.

  3. The Most Important Maglev Applications

    Directory of Open Access Journals (Sweden)

    Hamid Yaghoubi

    2013-01-01

    Full Text Available The name maglev is derived from magnetic levitation. Magnetic levitation is a highly advanced technology. It has various uses. The common point in all applications is the lack of contact and thus no wear and friction. This increases efficiency, reduces maintenance costs, and increases the useful life of the system. The magnetic levitation technology can be used as an efficient technology in the various industries. There are already many countries that are attracted to maglev systems. Many systems have been proposed in different parts of the worlds. This paper tries to study the most important uses of magnetic levitation technology. The results clearly reflect that the maglev can be conveniently considered as a solution for the future engineering needs of the world.

  4. Biological importance of marine algae.

    Science.gov (United States)

    El Gamal, Ali A

    2010-01-01

    Marine organisms are potentially prolific sources of highly bioactive secondary metabolites that might represent useful leads in the development of new pharmaceutical agents. Algae can be classified into two main groups; first one is the microalgae, which includes blue green algae, dinoflagellates, bacillariophyta (diatoms)… etc., and second one is macroalgae (seaweeds) which includes green, brown and red algae. The microalgae phyla have been recognized to provide chemical and pharmacological novelty and diversity. Moreover, microalgae are considered as the actual producers of some highly bioactive compounds found in marine resources. Red algae are considered as the most important source of many biologically active metabolites in comparison to other algal classes. Seaweeds are used for great number of application by man. The principal use of seaweeds as a source of human food and as a source of gums (phycocollides). Phycocolloides like agar agar, alginic acid and carrageenan are primarily constituents of brown and red algal cell walls and are widely used in industry.

  5. Buying Local or Imported Goods?

    DEFF Research Database (Denmark)

    Ayob, Abu H.; Hussain, Wan Mohd Hirwani Wan

    2016-01-01

    This study attempts to profile non-income consumers by examining their decisions to buy local or imported products. Hypotheses were drawn from discussions on the comparative advantages of advanced and developing countries, as well as the effects of a product’s country-of-origin on customers......’ purchasing decisions. Data was collected on 296 university students in Malaysia and analyzed through probit regression analysis. The findings reveal that foreign products from advanced countries are preferred by male students because of the superior quality and brand image. On the other hand, family members...... encourage students to buy local products because they are perceived as being less expensive. Also, students who receive scholarships are more likely to buy local products than self-sponsored students. This research offers insights into ex-ante purchasing behavior in developing countries particularly among...

  6. The Importance of Experiential Learning

    Science.gov (United States)

    Stanford, Jennifer

    2017-04-01

    As student numbers increase year on year, the ability to provide experiential learning opportunities and individual formative feedback is decreasing. As an important mechanism for cementing understanding of key concept thresholds in physical Earth sciences, practical based learning is paramount, especially for students with diverse learning abilities. According to Steinaker & Bell's taxonomy, experiential learning and dissemination of information to peers is key for students to make the transition to being much deeper learners. Furthermore, practical based learning also provides opportunity for varied methods of assessment, which are otherwise more challenging to devise. I here present results from practical, experiential based learning within the context of Foundation Year teaching, which shows that predominantly, students found experiential learning to be both a positive and rewarding part of their curriculum. Key aspects of these findings are now being translated to the design of new curricula.

  7. Conflict management: importance and implications.

    Science.gov (United States)

    McKibben, Laurie

    2017-01-26

    Conflict is a consistent and unavoidable issue within healthcare teams. Despite training of nurse leaders and managers around areas of conflict resolution, the problem of staff relations, stress, sickness and retention remain. Conflict arises from issues with interpersonal relationships, change and poor leadership. New members of staff entering an already established healthcare team should be supported and integrated, to encourage mutual role respect between all team members and establish positive working relationships, in order to maximise patient care. This paper explores the concept of conflict, the importance of addressing causes of conflict, effective management, and the relevance of positive approaches to conflict resolution. Good leadership, nurturing positive team dynamics and communication, encourages shared problem solving and acceptance of change. Furthermore mutual respect fosters a more positive working environment for those in healthcare teams. As conflict has direct implications for patients, positive resolution is essential, to promote safe and effective delivery of care, whilst encouraging therapeutic relationships between colleagues and managers.

  8. THE IMPORTANCE OF CSR IMPLEMENTATION

    Directory of Open Access Journals (Sweden)

    Anna Križanová

    2016-09-01

    Full Text Available The last three decades of the twentieth century and the beginning of the twenty-first century were marked by the expansion of managerial ethics and social responsibility of business. Business ceased to be perceived in terms of profit being the sole interest of management, and ethical aspects were stressed more so in connection with the company’s management. Specific managerial ethical initiatives and activities leading from outside and inside the organization constitutes the concept of Corporate Social Responsibility (CSR, which comprises many factors. The aim of this paper is to summarize the positive impact of corporate social responsibility for business activities using secondary data from global surveys and then confirm the importance and benefits of corporate social responsibility for enterprises in the Slovak Republic using primary data.

  9. Imported chikungunya fever in Madrid.

    Science.gov (United States)

    Richi Alberti, Patricia; Steiner, Martina; Illera Martín, Óscar; Alcocer Amores, Patricia; Cobo Ibáñez, Tatiana; Muñoz Fernández, Santiago

    2016-01-01

    Chikungunya Fever is a mosquito-transmitted viral disease that causes fever, rash and musculoskeletal complaints. The latest may persist for several months, or even years or developed a relapsing course, that deserve an adequate treatment. Due to the large outbreak declared in the Caribbean in 2013, imported cases of Chikungunya as well as the risk of autochthonous transmission in case of available vectors have increased in non-endemic countries, like Spain. We described four cases of Chikungunya treated in our clinic. Copyright © 2015 Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología. All rights reserved.

  10. Nephrolithiasis-induced end stage renal disease

    Science.gov (United States)

    Ounissi, M; Gargueh, T; Mahfoudhi, M; Boubaker, K; Hedri, H; Goucha, R; Abderrahim, E; Ben Hamida, F; Ben Abdallah, T; El Younsi, F; Ben Maiz, H; Kheder, A

    2010-01-01

    Introduction: Nephrolithiasis still remains a too frequent and underappreciated cause of end stage renal disease (ESRD). Methods and patients: Of the entire cohort of 7128 consecutive patients who started maintenance dialysis in our nephrology department between January 1992 and December 2006, a total of 45 patients (26 women, 19 men) had renal stone disease as the cause of ESRD. The type of nephrolithiasis was determined in 45 cases and etiology in 42. The treatment and evolution of stone disease and patient’s survival were studied. Results: The overall proportion of nephrolithiasis related ESRD was 0.63%. The mean age was 48.4 years. Infection stones (struvite) accounted for 40%, calcium stones, 26.67% (primary hyperparathyroidism:15.56%; familial hypercalciuria: 4.44%, unknown etiology: 6.66%), primary hyperoxaluria type 1, 17.78% and uric acid lithiasis in 15.56% of cases. The mean delay of the evolution of the stone renal disease to chronic renal failure was 85.8 months. The feminine gender, obesity and elevated alkaline phosphatases >128 IU/L were significantly correlated with fast evolution of ESRD. The median evolution to ESRD was 12 months. The normal body mass index (BMI), medical treatment of stone and primary hyperoxaluria type 1 were correlated with fast evolution to ESRD. All patients were treated by hemodialysis during a mean evolution of 60 months. Sixteen patients died. The patient's survival rate at 1, 3 and 5 years was 97.6, 92.8 and 69% respectively. Hypocalcemia, cardiopathy and normal calcium-phosphate product were significantly correlated with lower survival rate. Conclusion: Severe forms of nephrolithiasis remain an underestimated cause of ESRD. These findings highlight the crucial importance of accurate stone analysis and metabolic evaluation to provide early diagnosis and efficient treatment for conditions leading to ESRD. PMID:21694924

  11. Current trends in staging rectal cancer

    Institute of Scientific and Technical Information of China (English)

    Abdus Samee; Chelliah Ramachandran Selvasekar

    2011-01-01

    Management of rectal cancer has evolved over the years.In this condition preoperative investigations assist in deciding the optimal treatment.The relation of the tumor edge to the circumferential margin (CRM) is an important factor in deciding the need for neoadjuvant treatment and determines the prognosis.Those with threatened or involved margins are offered long course chemoradiation to enable R0 surgical resection.Endoanal ultrasound (EUS) is useful for tumor (T) staging;hence EUS is a useful imaging modality for early rectal cancer.Magnetic resonance imaging (MRI) is useful for assessing the mesorectum and the mesorectal fascia which has useful prognostic significance and for early identification of local recurrence.Computerized tomography (CT) of the chest,abdomen and pelvis is used to rule out distant metastasis.Identification of the malignant nodes using EUS,CT and MRI is based on the size,morphology and internal characteristics but has drawbacks.Most of the common imaging techniques are suboptimal for imaging following chemoradiation as they struggle to differentiate fibrotic changes and tumor.In this situation,EUS and MRI may provide complementary information to decide further treatment.Functional imaging using positron emission tomography (PET) is useful,particularly PET/CT fusion scans to identify areas of the functionally hot spots.In the current state,imaging has enabled the multidisciplinary team of surgeons,oncologists,radiologists and pathologists to decide on the patient centered management of rectal cancer.In future,functional imaging may play an active role in identifying patients with lymph node metastasis and those with residual and recurrent disease following neoadjuvant chemoradiotherapy.

  12. Blood protozoa of imported birds.

    Science.gov (United States)

    Manwell, R D; Rossi, G S

    1975-02-01

    Large numbers of birds, until recently, were brought into the United States each year. Countries of origin were varied, and included those of Australasia, Africa, South America, and the Caribbean islands, as well as other places. With them of course come their parasites, some of which may be potential pathogens to domestic avifauna. In part for this reason, a survey was undertaken of blood parasites of birds from pet shops and importers. So far a total of 1234 birds belonging to 186 species has been examined. Several new species and subspecies of avian Plasmodium have been found in the course of this study, including P. octamerium Manwell, 1968 in a Pintail Whydah, Vidua macoura, from Africa; P paranucleophilum Manwell & Sessler, 1971 in a South American tanager, Tachyphonus sp; and P. nucleophilum toucani Manwell & Sessler 1971 in a Swainson's Toucan, Ramphastos s. swainsonii. Plasmodium huffi Muniz, Soares & Battista is undoubtedly a synonym pro parte for the last. Plasmodium tenue Laveran & Maruliaz, long thought to be a synonym of Plasmodium vaughani Novy & MacNeal, was rediscovered and found to be a valid species. Plasmodium nucleophilum, infrequently seen in the New World, occurred in many Asian and African birds, and especially in starlings. Infections with other species of Plasmodium were common. Haemoproteus was the commonest blood parasite; Leucocytozoon was very rare as was Atoxoplasma (Lankesterella). The 2 families of birds best represented were the Fringillidae and the Psittacidae, but no blood parasites were seen in the latter. It is clear that imported birds are often infected with blood protozoa, some of which are unknown from native birds.

  13. Assessment of Stage 35 With APNASA

    Science.gov (United States)

    Celestina, Mark L.; Mulac, Richard

    2009-01-01

    An assessment of APNASA was conducted at NASA Glenn Research Center under the Fundamental Aeronautics Program to determine their predictive capabilities. The geometry selected for this study was Stage 35 which is a single stage transonic compressor. A speedline at 100% speed was generated and compared to experimental data at 100% speed for two turbulence models. Performance of the stage at 100% speed and profiles of several key aerodynamic parameters are compared to the survey data downstream of the stator in this report. In addition, hub leakage was modeled and compared to solutions without leakage and the available experimental data.

  14. Comparing Stage Presence and Virtual Reality Presence

    Directory of Open Access Journals (Sweden)

    Sebastian Xavier Samur

    2016-05-01

    Full Text Available Reflecting on the impending release of new Head Mounted Display virtual reality (VR technologies, the article examines definitions and techniques for digital presence, and compares them with research into stage presence. It opens with an outline of definitions of digital presence, comparing them with Cormac Power’s fictional, auratic, and literal modes of presence in performance. The article then looks at techniques used in VR and on stage to achieve presence. Finally, performance examples that use virtual reality technologies are presented. The article concludes that even if the technology falls short, discourse on digital presence is useful in providing insights into presence on stage.

  15. Staging mammography nonadherent women: a qualitative study.

    Science.gov (United States)

    LaPelle, Nancy; Costanza, Mary E; Luckmann, Roger; Rosal, Milagros C; White, Mary Jo; Stark, Jennifer Rider

    2008-01-01

    Few studies have related stages of mammography screening nonadherence with the rationale used by overdue women. We used a grounded theory approach to obtain and analyze data from focus groups, telephone interviews, and surveys. Emergent specific themes were compared with emerging decision levels of nonadherence. Each decision level was then compared with the Precaution Adoption Process Model and the Transtheoretical Model. A total of 6 key themes influencing mammogram nonadherence emerged as did 6 decision levels. Variability within themes was associated with specific decision levels. The decision levels were not adequately classified by either stage model. Stage-based educational strategies may benefit by tailoring interventions to these 6 decision levels.

  16. The conundrum of parapsoriasis versus patch stage of mycosis fungoides.

    Science.gov (United States)

    Sarveswari, K N; Yesudian, Patrick

    2009-01-01

    Terminological confusion with benign dermatosis, such as parapsoriasis en plaques, makes it difficult to diagnose mycosis fungoides in the early patch stage. Early diagnosis of mycosis fungoides (MF) is important for deciding on type of therapy, prognosis and for further follow-up. However, until recently, there has been no consensus on criteria that would help in diagnosing the disease early. Some believe that large plaque parapsoriasis (LPP) should be classified with early patch stage of MF and should be treated aggressively. However, there is no firm clinical or laboratory criteria to predict which LPP will progress to MF and we can only discuss about statistical probability. Moreover, long-term outcome analysis of even patch stage of MF is similar to that of control population. We therefore believe that LPP should be considered as a separate entity at least to prevent the patient from being given a frightening diagnosis. We also feel that patients need not be treated with aggressive therapy for LPP and will need only a close follow-up. This article emphasizes the criteria for diagnosing early MF and has highlighted the importance of considering LPP as a distinct benign entity.

  17. The conundrum of parapsoriasis versus patch stage of mycosis fungoides

    Directory of Open Access Journals (Sweden)

    Sarveswari K

    2009-01-01

    Full Text Available Terminological confusion with benign dermatosis, such as parapsoriasis en plaques, makes it difficult to diagnose mycosis fungoides in the early patch stage. Early diagnosis of mycosis fungoides (MF is important for deciding on type of therapy, prognosis and for further follow-up. However, until recently, there has been no consensus on criteria that would help in diagnosing the disease early. Some believe that large plaque parapsoriasis (LPP should be classified with early patch stage of MF and should be treated aggressively. However, there is no firm clinical or laboratory criteria to predict which LPP will progress to MF and we can only discuss about statistical probability. Moreover, long-term outcome analysis of even patch stage of MF is similar to that of control population. We therefore believe that LPP should be considered as a separate entity at least to prevent the patient from being given a frightening diagnosis. We also feel that patients need not be treated with aggressive therapy for LPP and will need only a close follow-up. This article emphasizes the criteria for diagnosing early MF and has highlighted the importance of considering LPP as a distinct benign entity.

  18. Nutrient Acquisition and Generation of Reactive Oxygen Species Via CREA, AREA, and NOXa are Important in Pathogenicity in Mycosphaerella Graminicola

    Science.gov (United States)

    Mycosphaerella graminicola is an important wheat pathogen causing significant economic loss. M. graminicola is a hemibiotroph, indicating that a biotrophic stage with nutrient uptake and a necrotrophic stage associated with a possible toxin or reactive oxygen species (ROS) are important to pathogeni...

  19. Genomic predictors for treatment of late stage prostate cancer

    Directory of Open Access Journals (Sweden)

    Daniel H Shevrin

    2016-01-01

    Full Text Available In spite of the development of new treatments for late stage prostate cancer, significant challenges persist to match individuals with effective targeted therapies. Genomic classification using high-throughput sequencing technologies has the potential to achieve this goal and make precision medicine a reality in the management of men with castrate-resistant prostate cancer. This chapter reviews some of the most recent studies that have resulted in significant progress in determining the landscape of somatic genomic alterations in this cohort and, more importantly, have provided clinically actionable information that could guide treatment decisions. This chapter reviews the current understanding of common alterations such as alterations of the androgen receptor and PTEN pathway, as well as ETS gene fusions and the growing importance of PARP inhibition. It also reviews recent studies that characterize the evolution to neuroendocrine tumors, which is becoming an increasingly important clinical problem. Finally, this chapter reviews recent innovative studies that characterize the compelling evolutionary history of lethal prostate cancer evidenced by polyclonal seeding and interclonal cooperation between metastasis and the importance of tumor clone dynamics measured serially in response to treatment. The genomic landscape of late stage prostate cancer is becoming better defined, and the prospect for assigning clinically actionable data to inform rationale treatment for individuals with this disease is becoming a reality.

  20. PET for Staging of Esophageal Cancer

    Institute of Scientific and Technical Information of China (English)

    A.H.Hoelscher

    2004-01-01

    FDG-PET is of clinical value especially for detection of distant metastases or recurrent esophageal cancer. For the staging of primary tumor or locoregional lymph node metastasis PET is currently not suitable.

  1. Classification in two-stage screening.

    Science.gov (United States)

    Longford, Nicholas T

    2015-11-10

    Decision theory is applied to the problem of setting thresholds in medical screening when it is organised in two stages. In the first stage that involves a less expensive procedure that can be applied on a mass scale, an individual is classified as a negative or a likely positive. In the second stage, the likely positives are subjected to another test that classifies them as (definite) positives or negatives. The second-stage test is more accurate, but also more expensive and more involved, and so there are incentives to restrict its application. Robustness of the method with respect to the parameters, some of which have to be set by elicitation, is assessed by sensitivity analysis.

  2. Low-level waste feed staging plan

    Energy Technology Data Exchange (ETDEWEB)

    Certa, P.J.; Grams, W.H.; McConville, C.M.; L. W. Shelton, L.W.; Slaathaug, E.J., Westinghouse Hanford

    1996-08-12

    The `Preliminary Low-Level Waste Feed Staging Plan` was updated to reflect the latest requirement in the Tank Waste Remediation Privatization Request for Proposals (RFP) and amendments. The updated plan develops the sequence and transfer schedule for retrieval of DST supernate by the management and integration contractor and delivery of the staged supernate to the private low-activity waste contractors for treatment. Two DSTs are allocated as intermediate staging tanks. A transfer system conflict analysis provides part of the basis for determining transfer system upgrade requirements to support both low-activity and high-level waste feed delivery. The intermediate staging tank architecture and retrieval system equipment are provided as a planning basis until design requirements documents are prepared. The actions needed to successfully implement the plan are identified. These include resolution of safety issues and changes to the feed envelope limits, minimum order quantities, and desired batch sizes.

  3. Spring staging waterfowl on the Naknek River

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Alaska Peninsula/Becharof National Wildlife Refuge staff conducted a survey of spring staging waterfowl on the Naknek River in the Bristol Bay drainage, Alaska...

  4. Two stage gear tooth dynamics program

    Science.gov (United States)

    Boyd, Linda S.

    1989-01-01

    The epicyclic gear dynamics program was expanded to add the option of evaluating the tooth pair dynamics for two epicyclic gear stages with peripheral components. This was a practical extension to the program as multiple gear stages are often used for speed reduction, space, weight, and/or auxiliary units. The option was developed for either stage to be a basic planetary, star, single external-external mesh, or single external-internal mesh. The two stage system allows for modeling of the peripherals with an input mass and shaft, an output mass and shaft, and a connecting shaft. Execution of the initial test case indicated an instability in the solution with the tooth paid loads growing to excessive magnitudes. A procedure to trace the instability is recommended as well as a method of reducing the program's computation time by reducing the number of boundary condition iterations.

  5. Konkurss "Sony Jazz Stage" otsib uusi talente

    Index Scriptorium Estoniae

    2006-01-01

    The Contemporary Music Centre'i korraldatavast konkursist "Sony Jazz Stage 2006". Võistlus toimub vokaali ja bassi (basskitarri või kontrabassi) kategoorias (The Contemporary Music Centre'i posti-või meiliaadress - vt. www.jazzkaar.ee)

  6. Konkurss "Sony Jazz Stage" otsib uusi talente

    Index Scriptorium Estoniae

    2006-01-01

    The Contemporary Music Centre'i korraldatavast konkursist "Sony Jazz Stage 2006". Võistlus toimub vokaali ja bassi (basskitarri või kontrabassi) kategoorias (The Contemporary Music Centre'i posti-või meiliaadress - vt. www.jazzkaar.ee)

  7. (Kangaroo grass) at various growth stages

    African Journals Online (AJOL)

    STORAGESEVER

    2009-04-06

    Apr 6, 2009 ... Key words: Kangaroo grass, biomass, dry matter, rangeland, growth stages. INTRODUCTION ... Soil organic matter, soil porosity and nutrient ... as soil moisture approaches field capacity (Nolan, 1994). Because Kangaroo ...

  8. Shielded multi-stage EMI noise filter

    Energy Technology Data Exchange (ETDEWEB)

    Kisner, Roger Allen; Fugate, David Lee

    2016-11-08

    Electromagnetic interference (EMI) noise filter embodiments and methods for filtering are provided herein. EMI noise filters include multiple signal exclusion enclosures. The multiple signal exclusion enclosures contain filter circuit stages. The signal exclusion enclosures can attenuate noise generated external to the enclosures and/or isolate noise currents generated by the corresponding filter circuits within the enclosures. In certain embodiments, an output of one filter circuit stage is connected to an input of the next filter circuit stage. The multiple signal exclusion enclosures can be chambers formed using conductive partitions to divide an outer signal exclusion enclosure. EMI noise filters can also include mechanisms to maintain the components of the filter circuit stages at a consistent temperature. For example, a metal base plate can distribute heat among filter components, and an insulating material can be positioned inside signal exclusion enclosures.

  9. Shielded multi-stage EMI noise filter

    Science.gov (United States)

    Kisner, Roger Allen; Fugate, David Lee

    2016-11-08

    Electromagnetic interference (EMI) noise filter embodiments and methods for filtering are provided herein. EMI noise filters include multiple signal exclusion enclosures. The multiple signal exclusion enclosures contain filter circuit stages. The signal exclusion enclosures can attenuate noise generated external to the enclosures and/or isolate noise currents generated by the corresponding filter circuits within the enclosures. In certain embodiments, an output of one filter circuit stage is connected to an input of the next filter circuit stage. The multiple signal exclusion enclosures can be chambers formed using conductive partitions to divide an outer signal exclusion enclosure. EMI noise filters can also include mechanisms to maintain the components of the filter circuit stages at a consistent temperature. For example, a metal base plate can distribute heat among filter components, and an insulating material can be positioned inside signal exclusion enclosures.

  10. Importance and Functions of Grasslands

    Directory of Open Access Journals (Sweden)

    Lucien CARLIER

    2009-06-01

    Full Text Available Grasslands, mixture of grass, clover and other leguminous species, dicotyledonous, herbs and shrubs, contribute to a high degree to the struggle against erosion and to the regularizing of water regimes, to the purification of fertilizers and pesticides and to biodiversity and they have aesthetic role and recreational function as far as they provide public access that other agricultural uses do not allow. Grassland will continue to be an important form of land use in Europe, but with increased diversity in management objectives and systems used. Besides its role as basic nutrient for herbivores and ruminants, grasslands have opportunities for an adding value by exploiting positive health characteristics in animal products from grassland and through the delivery of environmental benefits. But even for grassland it is very difficult to create a good frame for its different tasks (1 the provision of forage for livestock, (2 protection and conservation of soil and water resources, (3 furnishing a habitat for wildlife, both flora and fauna and (4 contribution to the attractiveness of the landscape. Nevertheless it is the only crop able to fulfil so many tasks and to fit so many requirements. In this article the focus is limited to the grass and clover components of the grasslands.

  11. ECOPHARMACOVIGILANCE: ITS IMPORTANCE AND CHALLENGES

    Directory of Open Access Journals (Sweden)

    Dr. Bhavana Srivastava

    2014-07-01

    Full Text Available Active pharmaceutical ingredients represent a group of emerging environmental contamination. Even in trace amounts, they are of great concern due to then continuous introduction into the environment, their impact an ecosystem and human and vetenery health is of great importance. This has given birth to the science of Ecopharmacovigilance (EPV. It aims to ensure that significant environmental issues associated with pharmaceuticals in the environment are identified and managed appropriately. EPV has become a research hotspot in Europe and North America. Environmental Risk assessment (ERA is now a regulatory requirement prior to launch of any new drug. The biggest difference and greatest challenge concerns signal detection in the environment and the dilemma of identifying cause and effect. In the background of growing Indian pharmaceutical industry and drug consumption, India should shoulder responsibility for its own environment and people along with the world ecosystem. Compared to the west EPV in India is in infancy ERA is now a regulatory requirement prior to launch of any new drug. However there is no formal frame-work to monitor for potential adverse effects in the environment, once a product has been launched. There should be laws and regulations on EPV, rational medication, drug take back programs, strengthening policy guided and scientific researches on EPV by pharmaceutical firms and academia.

  12. [Importance of psychology in dentistry].

    Science.gov (United States)

    Peñaranda, P

    1990-01-01

    In this paper, the venezuelan dentists express their necessities of knowing certain aspects of psychology that could be useful in the relations with their patients. In the investigation a 16 item questionnaire was elaborated, taking 5 areas in consideration: a. Psychological management of the dental patient. b. Psychological consequences of the dental disease. c. Dental disease psychogenesis. d. Patient first contact behavior. e. Aspects of work organization. 100 dentists and 100 dental students of the last 2 years were inquired, in order to compare these two populations at the XXXth Congress of the venezuelan dentists. The two proportion coefficient test was used with: P less than or equal to 0.01. As a result 4 groups of items had a significant difference: a. Patient dissertation. b. Children with problematic behavior. c. Anxious patients; and d. Professional fees. Quantitatively 16 items were recognized as items in with Psychology could be useful to be applied in dentistry. The article concludes with 6 recommendations underlining the important role of the dental psychology in the dental school as well as in private practice.

  13. Van Allen Discovery Most Important

    Science.gov (United States)

    Jastrow, R.

    1959-01-01

    The first step toward the exploration of space occurred approximately 22 months ago as a part of the International Geophysical Year. In the short interval since October, 1957, the new tools of research, the satellite and the space rocket, have produced two unexpected results of fundamental scientific importance. First, instruments placed in the Explorer satellites by James A. Van Allen have revealed the existence of layers of energetic particles in the outer atmosphere. This discovery constitutes the most significant research achievement of the IGY satellite program. The layers may provide the explanation for the aurora and other geophysical phenomena, and they will also influence the design of vehicles for manned space flight, whose occupants must be shielded against their harmful biological effects. Second, the shape of the earth has been determined very accurately with the aid of data from the first Vanguard. As a result of this investigation, we have found that our planet tends toward the shape of a pear, with its stem at the North Pole. This discovery may produce major changes in our ideas on the interior structure of the earth.

  14. Management of Early-stage Hodgkin Lymphoma: A Practice Guideline.

    Science.gov (United States)

    Herst, J; Crump, M; Baldassarre, F G; MacEachern, J; Sussman, J; Hodgson, D; Cheung, M C

    2017-01-01

    In the past, treatment for patients with early-stage Hodgkin lymphoma consisted mainly of radiotherapy. Now, chemotherapy alone and chemoradiotherapy are treatment options. These guidelines aim to provide recommendations on the optimal management of early-stage Hodgkin lymphoma. We conducted a systematic review searching MEDLINE, EMBASE, the Cochrane Library and other literature sources from 2003 to 2015, and applied the Grading of Recommendations Assessment, Development and Evaluation (GRADE). Two authors independently reviewed and selected studies, and appraised the evidence quality. The document underwent internal and external review by content, methodology experts, a patient representative and clinicians in Ontario. We have issued recommendations for patients with classical Hodgkin lymphoma and with nodular lymphocyte predominant Hodgkin lymphoma; with favourable and unfavourable prognosis; and for the use of positron emission tomography to direct treatment. We have provided our interpretation of the evidence and considerations for implementation. Examples of recommendations are: 'Patients with early-stage classical Hodgkin lymphoma should not be treated with radiotherapy alone'; 'chemotherapy plus radiotherapy or chemotherapy alone are recommended treatment options for patients with early-stage non-bulky Hodgkin lymphoma'; 'The Working Group does not recommend the use of a negative interim positron emission tomography scan alone to identify patients with early-stage Hodgkin lymphoma for whom radiotherapy can be omitted without a reduction in progression-free survival'. Through the use of GRADE, recommendations were geared towards patient important outcomes and their strength reflected the available evidence and its interpretation from the patients' point of view. Copyright © 2016 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.

  15. Phyllostomid Bat Occurrence in Successional Stages of Neotropical Dry Forests

    Science.gov (United States)

    Avila-Cabadilla, Luis Daniel; Stoner, Kathryn Elizabeth; Nassar, Jafet M.; Espírito-Santo, Mario M.; Alvarez-Añorve, Mariana Yolotl; Aranguren, Carla I.; Henry, Mickael; González-Carcacía, José A.; Dolabela Falcão, Luiz A.; Sanchez-Azofeifa, Gerardo Arturo

    2014-01-01

    Tropical dry forests (TDFs) are highly endangered tropical ecosystems being replaced by a complex mosaic of patches of different successional stages, agricultural fields and pasturelands. In this context, it is urgent to understand how taxa playing critical ecosystem roles respond to habitat modification. Because Phyllostomid bats provide important ecosystem services (e.g. facilitate gene flow among plant populations and promote forest regeneration), in this study we aimed to identify potential patterns on their response to TDF transformation in sites representing four different successional stages (initial, early, intermediate and late) in three Neotropical regions: México, Venezuela and Brazil. We evaluated bat occurrence at the species, ensemble (abundance) and assemblage level (species richness and composition, guild composition). We also evaluated how bat occurrence was modulated by the marked seasonality of TDFs. In general, we found high seasonal and regional specificities in phyllostomid occurrence, driven by specificities at species and guild levels. For example, highest frugivore abundance occurred in the early stage of the moistest TDF, while highest nectarivore abundance occurred in the same stage of the driest TDF. The high regional specificity of phyllostomid responses could arise from: (1) the distinctive environmental conditions of each region, (2) the specific behavior and ecological requirements of the regional bat species, (3) the composition, structure and phenological patterns of plant assemblages in the different stages, and (4) the regional landscape composition and configuration. We conclude that, in tropical seasonal environments, it is imperative to perform long-term studies considering seasonal variations in environmental conditions and plant phenology, as well as the role of landscape attributes. This approach will allow us to identify potential patterns in bat responses to habitat modification, which constitute an invaluable tool for

  16. Inertial Upper Stage Thermal Test Program

    Science.gov (United States)

    1989-04-12

    REPORT SD-TR-89-26 Inertial Upper Stage Thermal Test Program D. J. SPENCER and H. A. BIXLER Aerophysics Laboratory Laboratory Operations The...TITLE (Include Security Classification) Inertial Upper Stage Thermal Test Program 12. PERSONAL AUTHOR(S) Spencer, Donald J., and Bixler, Henry A. 13a...by the laboratory thermal test program under consideration here. Details of the IUS launch vehicle characteristics and corrective action taken in

  17. Radiation Therapy for Early Stage Lung Cancer

    OpenAIRE

    Parashar, Bhupesh; Arora, Shruthi; Wernicke, A. Gabriella

    2013-01-01

    Radiation therapy for early stage lung cancer is a promising modality. It has been traditionally used in patients not considered candidates for standard surgical resection. However, its role has been changing rapidly since the introduction of new and advanced technology, especially in tumor tracking, image guidance, and radiation delivery. Stereotactic radiation therapy is one such advancement that has shown excellent local control rates and promising survival in early stage lung cancer. In a...

  18. Radiation Therapy for Early Stage Lung Cancer

    OpenAIRE

    Parashar, Bhupesh; Arora, Shruthi; Wernicke, A. Gabriella

    2013-01-01

    Radiation therapy for early stage lung cancer is a promising modality. It has been traditionally used in patients not considered candidates for standard surgical resection. However, its role has been changing rapidly since the introduction of new and advanced technology, especially in tumor tracking, image guidance, and radiation delivery. Stereotactic radiation therapy is one such advancement that has shown excellent local control rates and promising survival in early stage lung cancer. In a...

  19. INNOVATION DIFFUSION THEORY MAIN DEVELOPMENT STAGES

    Directory of Open Access Journals (Sweden)

    S. V. Lisafiev

    2011-01-01

    Full Text Available Abstract: Main innovation diffusion development theory stages are: Rogers model of moving new products to the market including characteristics of its segments; mathematic substantiation of this model by Bass; Moor model taking into account gaps between adjacent market segments; Goldenberg model making it possible to predict sales drops at new product life cycle initial stages. It is reasonable to use this theory while moving innovative products to the market.

  20. [Pleural mesothelioma: impact of the staging for the therapeutic strategy].

    Science.gov (United States)

    Greillier, L; Scherpereel, A; Astoul, P

    2007-10-01

    Realistic improvement has been recently done for the treatment of malignant pleural mesothelioma. Besides new findings for the epidemiology of the disease, medico-social impact for patients, the knowledge of biological parameters for diagnosis, prognosis and future therapeutic targets as well, the early diagnosis of the disease mainly based on more extended practice of thoracoscopy allows in association with new imaging techniques a careful staging of the disease and consequently new therapeutic implications. Indeed if new balistic assessment of the disease improves the efficacy of radiotherapy and new combined chemotherapy have shown antitumoral responses, surgical strategy takes part in the armamenterium for this disease and combined with others therapeutic modalities seems to be a raisonnable approach despite the lack of prospective, comparative, randomized study and the drawback of current staging. However, the most important point is the multidisciplinary concertation induced by the management of this disease which represents a "model" in thoracic oncology.

  1. Teacher's Roles & Autonomous Learning in Each Stage of Language Learning

    Institute of Scientific and Technical Information of China (English)

    李小艳

    2009-01-01

    This paper closely examines the languange learning process and characteristics ofeach stage running the whole gamut ofthis process,by which this paper moves on to the diScussion of the roles of teachers and learners,then fmally comes to a reasonable conclusion:learners and teachers play different but equally important roles in the process of language learning.The problem does not lie in reducing teachers'role to the minimum,nor in creating a learner's autonomous learning approach,but consists in clarifmg a proper roles oflearners and teachers and choosing suitable approaches in different stages oflanguage learning.Resorting to this optimized combination ofroles and approaches,the maximum output can be delivered.

  2. Two-stage approach to full Chinese parsing

    Institute of Scientific and Technical Information of China (English)

    Cao Hailong; Zhao Tiejun; Yang Muyun; Li Sheng

    2005-01-01

    Natural language parsing is a task of great importance and extreme difficulty. In this paper, we present a full Chinese parsing system based on a two-stage approach. Rather than identifying all phrases by a uniform model, we utilize a divide and conquer strategy. We propose an effective and fast method based on Markov model to identify the base phrases. Then we make the first attempt to extend one of the best English parsing models i.e. the head-driven model to recognize Chinese complex phrases. Our two-stage approach is superior to the uniform approach in two aspects. First, it creates synergy between the Markov model and the head-driven model. Second, it reduces the complexity of full Chinese parsing and makes the parsing system space and time efficient. We evaluate our approach in PARSEVAL measures on the open test set, the parsing system performances at 87.53% precision, 87.95% recall.

  3. Focus on Merkel cell carcinoma: diagnosis and staging

    Energy Technology Data Exchange (ETDEWEB)

    Grandhaye, Marion; Teixeira, Pedro Gondim; Blum, Alain [Imagerie Guilloz CHU de Nancy Hopital Central, Nancy (France); Henrot, Philippe [Service de Radiologie Institut de Cancerologie de Lorraine, Vandoeuvre les Nancy (France); Morel, Olivier [Medecine Nucleaire CHU Nancy Hopital Brabois, Vancoeuvre les Nancy (France); Sirveaux, Francois [Service de Chirurgie Centre chirurgical Emile Galle, Nancy (France); Verhaeghe, Jean-Luc [Service de Chirurgie Institut de Cancerologie de Lorraine, Vandoeuvre les Nancy (France)

    2015-06-01

    Merkel cell carcinoma is a rare lymphophilic skin tumor of neuroendocrine origin with the potential for rapid progression. Small, localized lesions are diagnosed and treated clinically, but advanced tumors often undergo imaging evaluation. Due to its rarity, radiologists are unaware of evocative imaging features and usually do not consider Merkel cell carcinoma in the differential diagnosis of soft tissue tumors. Appropriate staging is important to determine appropriate treatment and has an impact on patient prognosis. Multimodality imaging is usually needed, and there is no consensus on the optimal imaging strategy. The purpose of this article is to review various aspects of Merkel cell carcinoma imaging and look in detail at how optimal multimodality staging should be carried out. (orig.)

  4. Application of Wavelet Fractal Dimension Estimation Method on Flood Season Staged

    Institute of Scientific and Technical Information of China (English)

    Wang Xianjia; Dong Qianjin; Ai Xueshan; Zhang Yanmin

    2006-01-01

    Floodwater utilization is an important content in flood management. Controlling the limit water level of reservoir by stage is one of important contents in the management of multi-purpose reservoir's floodwater utilization for the sake of more benefits, and reasonable division of stage in flood season is precondition of controlling the limit water level by stage. On the background of Three Gorges Reservoir floodwater utilization management and on the foundation of self-similarity of hydrological series, determining the number of flood season staged in base of conventional statistical method, choosing the Db4 wavelet and Mallat algorithm, the computation mode of wavelet fractal dimension estimation method is proposed and each stage's fractal dimension is computed, then the final flood season staged is obtained. The results demonstrate the stages of Three Gorges Reservoir determined by using wavelet fractal dimension method are consistent with that from conventional method, but the fractal dimension results by former method are easier, more stable and objective which ensures the feasibility of the wavelet fractal dimension method applying in flood season staged. The obtained results are the base of deep coping with floodwater utilization management, also are the decision-making gist for the flood forecast, flood control and water allocation reasonably of Three Gorges Reservoir.

  5. IMPORTANT PROTOZOAN PARASITES IN INDONESIA

    Directory of Open Access Journals (Sweden)

    Srisasi Gandahusada

    2012-09-01

    Full Text Available The most important protozoan parasites in Indonesia are the malaria parasites, Toxoplasma gondii and Entamoeba histolytica. After the second world war the residual insecticides and effective antimalarial drugs were used in the control of malaria. After development of resistance among mosquitoes to insecticides, the Malaria Control Programme was switched over to the Malaria Eradication Programme. Malaria incidence dropped heavily. However, due to the quick development of vector resistance and financial limitations, malaria came back and so did the Malaria Control Programme. P. falciparum and P.vivax are the most common species in Indonesia. Important vectors are An. sundaicus, An. aconitus, An. maculatus, An. hyrcanus group, An. balabacensis, An. farauti etc. An. sundaicus and An. aconitus have developed resistance to DDT and Dieldrin in Java. In 1959 the Malaria Eradication Programme was started in Java, Bali and Lampung. In 1965 the API dropped to 0,15 per thousand. From 1966 onwards malaria transmission was on the increase, because spraying activities were slowed down, but dropped again from 1974 onwards by occasional residual house spraying with DDT or Fenitrothion, malaria surveillance and treatment of malaria cases, resulting in an API of 0.18 per thousand in 1987. At present malaria is not transmitted in Jakarta and in capitals of the provinces and kabupatens, except in Irian Jaya, Nusa Tenggara Timur and one or two other provinces, but it still exists in rural areas. The distribution of chloroquine resistant P.falciparum is patchy. Resistance is at the RI, RII and RUT levels. The main problems of malaria control are : the increasing development of resistance of the vector to insecticides, the change of An.aconitus from zoophili to anthropophili and from indoor to outdoor biting, the increasing resistance of P.falciparum to chloroquine, the shortage of skilled manpower and limitation of budget. In Indonesia many newborns with congenital

  6. IMPORTANT PROTOZOAN PARASITES IN INDONESIA

    Directory of Open Access Journals (Sweden)

    Srisasi Gandahusada

    2012-09-01

    Full Text Available The most important protozoan parasites in Indonesia are the malaria parasites, Toxoplasma gondii and Entamoeba histolytica. After the second world war the residual insecticides and effective antimalarial drugs were used in the control of malaria. After development of resistance among mosquitoes to insecticides, the Malaria Control Programme was switched over to the Malaria Eradication Programme. Malaria incidence dropped heavily. However, due to the quick development of vector resistance and financial limitations, malaria came back and so did the Malaria Control Programme. P. falciparum and P.vivax are the most common species in Indonesia. Important vectors are An. sundaicus, An. aconitus, An. maculatus, An. hyrcanus group, An. balabacensis, An. farauti etc. An. sundaicus and An. aconitus have developed resistance to DDT and Dieldrin in Java. In 1959 the Malaria Eradication Programme was started in Java, Bali and Lampung. In 1965 the API dropped to 0,15 per thousand. From 1966 onwards malaria transmission was on the increase, because spraying activities were slowed down, but dropped again from 1974 onwards by occasional residual house spraying with DDT or Fenitrothion, malaria surveillance and treatment of malaria cases, resulting in an API of 0.18 per thousand in 1987. At present malaria is not transmitted in Jakarta and in capitals of the provinces and kabupatens, except in Irian Jaya, Nusa Tenggara Timur and one or two other provinces, but it still exists in rural areas. The distribution of chloroquine resistant P.falciparum is patchy. Resistance is at the RI, RII and RUT levels. The main problems of malaria control are : the increasing development of resistance of the vector to insecticides, the change of An.aconitus from zoophili to anthropophili and from indoor to outdoor biting, the increasing resistance of P.falciparum to chloroquine, the shortage of skilled manpower and limitation of budget. In Indonesia many newborns with congenital

  7. A New Framework of Human Interaction Recognition Based on Multiple Stage Probability Fusion

    Directory of Open Access Journals (Sweden)

    Xiaofei Ji

    2017-06-01

    Full Text Available Visual-based human interactive behavior recognition is a challenging research topic in computer vision. There exist some important problems in the current interaction recognition algorithms, such as very complex feature representation and inaccurate feature extraction induced by wrong human body segmentation. In order to solve these problems, a novel human interaction recognition method based on multiple stage probability fusion is proposed in this paper. According to the human body’s contact in interaction as a cut-off point, the process of the interaction can be divided into three stages: start stage, execution stage and end stage. Two persons’ motions are respectively extracted and recognizes in the start stage and the finish stage when there is no contact between those persons. The two persons’ motion is extracted as a whole and recognized in the execution stage. In the recognition process, the final recognition results are obtained by the weighted fusing these probabilities in different stages. The proposed method not only simplifies the extraction and representation of features, but also avoids the wrong feature extraction caused by occlusion. Experiment results on the UT-interaction dataset demonstrated that the proposed method results in a better performance than other recent interaction recognition methods.

  8. Effect of silver nanoparticles on Pseudomonas putida biofilms at different stages of maturity

    Energy Technology Data Exchange (ETDEWEB)

    Thuptimdang, Pumis, E-mail: pumis.th@gmail.com [International Program in Hazardous Substance and Environmental Management, Graduate School, Chulalongkorn University, Bangkok 10330 (Thailand); Center of Excellence on Hazardous Substance Management, Bangkok 10330 (Thailand); Limpiyakorn, Tawan, E-mail: tawan.l@chula.ac.th [Center of Excellence on Hazardous Substance Management, Bangkok 10330 (Thailand); Department of Environmental Engineering, Chulalongkorn University, Bangkok 10330 (Thailand); Research Unit Control of Emerging Micropollutants in Environment, Chulalongkorn University, Bangkok 10330 (Thailand); McEvoy, John, E-mail: john.mcevoy@ndsu.edu [Department of Veterinary and Microbiological Sciences, North Dakota State University, Fargo, ND 58108 (United States); Prüß, Birgit M., E-mail: birgit.pruess@ndsu.edu [Department of Veterinary and Microbiological Sciences, North Dakota State University, Fargo, ND 58108 (United States); Khan, Eakalak, E-mail: eakalak.khan@ndsu.edu [Department of Civil and Environmental Engineering, North Dakota State University, Fargo, ND 58108 (United States)

    2015-06-15

    Highlights: • Biofilm stages in static batch conditions were similar to dynamic conditions. • Expression of csgA gene increased earlier than alg8 gene in biofilm maturation. • AgNPs had higher effect on less mature biofilms. • Removal of extracellular polymeric substance made biofilms susceptible to AgNPs. - Abstract: This study determined the effect of silver nanoparticles (AgNPs) on Pseudomonas putida KT2440 biofilms at different stages of maturity. Three biofilm stages (1–3, representing early to late stages of development) were identified from bacterial adenosine triphosphate (ATP) activity under static (96-well plate) and dynamic conditions (Center for Disease Control and Prevention biofilm reactor). Extracellular polymeric substance (EPS) levels, measured using crystal violet and total carbohydrate assays, and expression of the EPS-associated genes, csgA and alg8, supported the conclusion that biofilms at later stages were older than those at earlier stages. More mature biofilms (stages 2 and 3) showed little to no reduction in ATP activity following exposure to AgNPs. In contrast, the same treatment reduced ATP activity by more than 90% in the less mature stage 1 biofilms. Regardless of maturity, biofilms with EPS stripped off were more susceptible to AgNPs than controls with intact EPS, demonstrating that EPS is critical for biofilm tolerance of AgNPs. The findings from this study show that stage of maturity is an important factor to consider when studying effect of AgNPs on biofilms.

  9. Investigation of an automatic sleep stage classification by means of multiscorer hypnogram.

    Science.gov (United States)

    Figueroa Helland, V C; Gapelyuk, A; Suhrbier, A; Riedl, M; Penzel, T; Kurths, J; Wessel, N

    2010-01-01

    Scoring sleep visually based on polysomnography is an important but time-consuming element of sleep medicine. Whereas computer software assists human experts in the assignment of sleep stages to polysomnogram epochs, their performance is usually insufficient. This study evaluates the possibility to fully automatize sleep staging considering the reliability of the sleep stages available from human expert sleep scorers. We obtain features from EEG, ECG and respiratory signals of polysomnograms from ten healthy subjects. Using the sleep stages provided by three human experts, we evaluate the performance of linear discriminant analysis on the entire polysomnogram and only on epochs where the three experts agree in their sleep stage scoring. We show that in polysomnogram intervals, to which all three scorers assign the same sleep stage, our algorithm achieves 90% accuracy. This high rate of agreement with the human experts is accomplished with only a small set of three frequency features from the EEG. We increase the performance to 93% by including ECG and respiration features. In contrast, on intervals of ambiguous sleep stage, the sleep stage classification obtained from our algorithm, agrees with the human consensus scorer in approximately 61%. These findings suggest that machine classification is highly consistent with human sleep staging and that error in the algorithm's assignments is rather a problem of lack of well-defined criteria for human experts to judge certain polysomnogram epochs than an insufficiency of computational procedures.

  10. Very early stages of massive stars

    Science.gov (United States)

    Vasyunina, Tatiana

    2010-12-01

    06058+2138. We perform an analysis of all the available data, covering the near- and mid-infrared as well as the centimeter and millimeter wavelength range. In particular new VLT/SINFONI integral- field spectroscopy data have played a pivotal role. We identify three star-forming clusters at different evolutionary stages. Comparing the relative ages of these clusters and their relative locations, we conclude that triggering could not have led to the cluster con guration we see in the region. Thus, we assume a merely sequential star-formation scenario for this region. With this study, we also demonstrate the importance of a multi-wavelength approach. Combining data at different wavelengths allows us to investigate both the more evolved stellar population, as well as very young embedded objects, and hence, to reconstruct the star-forming history of structured cluster environments.

  11. Extraoral implants for orbit rehabilitation: a comparison between one-stage and two-stage surgeries.

    Science.gov (United States)

    de Mello, M C L M P; Guedes, R; de Oliveira, J A P; Pecorari, V A; Abrahão, M; Dib, L L

    2014-03-01

    The aim of the study was to compare the osseointegration success rate and time for delivery of the prosthesis among cases treated by two-stage or one-stage surgery for orbit rehabilitation between 2003 and 2011. Forty-five patients were included, 31 males and 14 females; 22 patients had two-stage surgery and 23 patients had one-stage surgery. A total 138 implants were installed, 42 (30.4%) on previously irradiated bone. The implant survival rate was 96.4%, with a success rate of 99.0% among non-irradiated patients and 90.5% among irradiated patients. Two-stage patients received 74 implants with a survival rate of 94.6% (four implants lost); one-stage surgery patients received 64 implants with a survival rate of 98.4% (one implant lost). The median time interval between implant fixation and delivery of the prosthesis for the two-stage group was 9.6 months and for the one-stage group was 4.0 months (P < 0.001). The one-stage technique proved to be reliable and was associated with few risks and complications; the rate of successful osseointegration was similar to those reported in the literature. The one-stage technique should be considered a viable procedure that shortens the time to final rehabilitation and facilitates appropriate patient follow-up treatment.

  12. Design and Experiment of Vertical Motion Dual-stage with Piezo-actuated Nanopositioning Stage

    Institute of Scientific and Technical Information of China (English)

    Ren Jiaqi; Zhu Xiaobo; Chen Guozhen; Liu Pinkuan

    2015-01-01

    Nanopositioning stage based on piezoelectric (PZT ) actuators and flexure mechanisms has been widely used in dual-stage .Its favorable positioning accuracy and dynamic response can guarantee the high performance of the dual-stage .Here the vertical axis motion dual-stage is designed with piezoelectric actuator for the fine-stage and ball-screw drive integrated with wedge sliding mechanisms for the coarse-stage .The aim of the dual-stage is to meet the stringent requirement of scanning over a relative large range with high accuracy .The design results of the piezo-actuated nanopositioning stage show good static and dynamic performance ,validated by the simulation of fi-nite element analysis (FEA) .Hysteresis nonlinearity due to the use of piezoelectric stacks for actuation is studied and compensated by a proportional-integral (PI) feedback controller .To qualify the design of the motion ranges and resolutions ,an experiment platform is established .The experimental results show that the proposed dual-stage has a full range of 12 mm with the resolution of 40 nm .Guideline is provided for the design methodology of the vertical motion dual-range stages .

  13. [Breastfeeding: the importance of intervening].

    Science.gov (United States)

    Aguiar, Hélder; Silva, Ana Isabel

    2011-12-01

    Breast milk is considered by the WHO the ideal food for the first months of life. Although health professionals are aware of recommendations, high rates of drop-outs have been identified in Portugal. A false notion of hypogalactia is the major factor for early termination, which is allied to the technical difficulties of the feeding. Health professionals, often lacking training in the area, may have difficulty in reassuring mothers in these situations. In Portugal, at the 3rd month, most mothers stop breastfeeding by indication of their medical assistant. Gather evidence about the advantages of breast-feeding compared to artificial milk, and establish useful strategies in clinical practice to avoid early withdrawal. A survey was conducted for articles from the last six years in the major sites of evidence-based medicine and reference sites (Pubmed, Cochrane, National Guideline Clearinghouse, Tripdatabase, WHO). Breast-feeding is clearly associated with benefits to the infant, including significant protective effects for gastrointestinal infections (64%), middle ear (23- 50%), severe respiratory infections (73%) and for acute lymphocytic leukemia (19%) and sudden death syndrome in infants (36%). We also found long-term benefits, such as for obesity (7-24%) and other cardiovascular risk factors in adulthood. The mother also benefits from its protective effect for cancers of the breast and ovary, and diabetes mellitus type 2 as also, proportionate to the duration of breastfeeding. Health professionals have an important role in the initiation and continuation of breastfeeding. The notion of its advantages, the communication prior to delivery, accessibility support and training in technical aspects of correct picks are the proven strategies for evidence explored in the article. Breast milk contains several unique and exclusive elements, orchestrators of its health benefits. Postnatal period is critical to the development of neuro--hypothalamic circuits involved in

  14. Importance of macroprolactinemia in hyperprolactinemia.

    Science.gov (United States)

    Kasum, M; Pavičić-Baldani, D; Stanić, P; Orešković, S; Sarić, J-M; Blajić, J; Juras, J

    2014-12-01

    occur in patients with conventional symptoms of hyperprolactinemia who cannot be differentiated from patients with true hyperprolactinemia. These symptoms are mainly attributed to excess levels of monomeric prolactin, and this is of concern. The diagnosis of macroprolactinemia is misleading and inappropriate. A multitude of physiological, pharmacological and pathological causes, including stress, prolactinomas, hypothyroidism, renal and hepatic failure, intercostal nerve stimulation and polycystic ovary disease, can contribute to increased levels of monomeric prolactin. It is important for patients with elevated monomeric prolactin levels to undergo routine evaluation to identify the exact pathological state and introduce adequate treatment, regardless of the presence of macroprolactin. In addition, macroprolactinemia occasionally occurs due to macroprolactin associated with pituitary adenomas, with biological activity of macroprolactin comparable with that of monomeric prolactin. In cases when excess macroprolactin occurs with clinical manifestations of hyperprolactinemia, macroprolactinemia should be regarded as a pathological biochemical variant of hyperprolactinemia. An individualized approach to the management of such patients with macroprolactinemia may be necessary, and pituitary imaging, dopamine treatment and prolonged follow-up should be applied.

  15. Radiotherapy Improves Survival in Unresected Stage I-III Bronchoalveolar Carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Urban, Damien [Department of Oncology, Sheba Medical Center, Ramat Gan (Israel); Mishra, Mark [Department of Radiation Oncology, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania (United States); Onn, Amir [Department of Oncology, Sheba Medical Center, Ramat Gan (Israel); Dicker, Adam P. [Department of Radiation Oncology, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania (United States); Symon, Zvi; Pfeffer, M. Raphael [Department of Oncology, Sheba Medical Center, Ramat Gan (Israel); Sackler School of Medicine, Tel Aviv University, Tel Aviv (Israel); Lawrence, Yaacov Richard, E-mail: yaacovla@gmail.com [Department of Oncology, Sheba Medical Center, Ramat Gan (Israel); Department of Radiation Oncology, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania (United States); Sackler School of Medicine, Tel Aviv University, Tel Aviv (Israel)

    2012-11-01

    Purpose: To test the hypothesis that radiotherapy (RT) improves the outcome of patients with unresected, nonmetastatic bronchoalveolar carcinoma (BAC) by performing a population-based analysis within the Surveillance, Epidemiology, and End Results (SEER) registry. Methods and Materials: Inclusion criteria were as follows: patients diagnosed with BAC, Stage I-III, between 2001 and 2007. Exclusion criteria included unknown stage, unknown primary treatment modality, Stage IV disease, and those diagnosed at autopsy. Demographic data, treatment details, and overall survival were retrieved from the SEER database. Survival was analyzed using the Kaplan-Meier method and log-rank test. Results: A total of 6933 patients with Stage I-III BAC were included in the analysis. The median age at diagnosis was 70 years (range, 10-101 years). The majority of patients were diagnosed with Stage I (74.4%); 968 patients (14%) did not undergo surgical resection. Unresected patients were more likely to be older (p < 0.0001), male (p = 0.001), black (p < 0.0001), and Stage III (p < 0.0001). Within the cohort of unresected patients, 300 (31%) were treated with RT. The estimated 2-year overall survival for patients with unresected, nonmetastatic BAC was 58%, 44%, and 27% in Stage I, II, and III, respectively. Factors associated with improved survival included female sex, earlier stage at diagnosis, and use of RT. Median survival in those not receiving RT vs. receiving RT was as follows: Stage I, 28 months vs. 33 months (n = 364, p = 0.06); Stage II, 18 months vs. not reached (n = 31, nonsignificant); Stage III, 10 months vs. 17 months (n = 517, p < 0.003). Conclusions: The use of RT is associated with improved prognosis in unresected Stage I-III BAC. Less than a third of patients who could have potentially benefited from RT received it, suggesting that the medical specialists involved in the care of these patients underappreciate the importance of RT.

  16. IMPORTANCE OF 15 LEAD ECG

    Directory of Open Access Journals (Sweden)

    Bhargav

    2014-10-01

    the patients with IWMI where as it was 42% in patients of PWMI. History of alcoholism was present in 22% of IWMI patients and 38% in the patients of PWMI and 6% in IWMI without PWMI. Diabetes was seen in 30% of PWMI patients where as it was 35% in patients IWMI without PWMI and 34% overall. Hypotension was present in 46% of PWMI and 16% of IWMI without PWMI. Ventricular fibrillation was seen in 8% of PWMI and 2.8% of patients of IWMI without PWMI. Heart blocks were seen in 15% of PWMI and in 10% of patients of IWMI without PWMI. Mortality was 23% in PWMI and 10% in patients of IWMI without PWMI. INTERPRETATION AND CONCLUSION: The incidence of mortality and complications can be reduced only when we are fully aware of diagnosis and complications that can occur in PWMI. So, in all cases of IWMI, PWMI should be looked for by using simple and specific investigation like Posterior leads ECG. It should be kept in mind that incidence of complications like hypotension, conduction defects and arrhythmias are very high in PWMI and hence early detection is important.

  17. Cisplatin and Radiation Therapy With or Without Triapine in Treating Patients With Previously Untreated Stage IB-IVA Cervical Cancer or Stage II-IVA Vaginal Cancer

    Science.gov (United States)

    2016-03-25

    Cervical Adenocarcinoma; Cervical Adenosquamous Carcinoma; Cervical Squamous Cell Carcinoma; Stage IB2 Cervical Cancer; Stage II Vaginal Cancer; Stage IIA1 Cervical Cancer; Stage IIA2 Cervical Cancer; Stage IIB Cervical Cancer; Stage III Vaginal Cancer; Stage IIIA Cervical Cancer; Stage IIIB Cervical Cancer; Stage IVA Cervical Cancer; Stage IVA Vaginal Cancer; Vaginal Adenocarcinoma; Vaginal Adenosquamous Carcinoma; Vaginal Squamous Cell Carcinoma

  18. Evaluation of lymph node numbers for adequate staging of Stage II and III colon cancer

    Directory of Open Access Journals (Sweden)

    Bumpers Harvey L

    2011-05-01

    Full Text Available Abstract Background Although evaluation of at least 12 lymph nodes (LNs is recommended as the minimum number of nodes required for accurate staging of colon cancer patients, there is disagreement on what constitutes an adequate identification of such LNs. Methods To evaluate the minimum number of LNs for adequate staging of Stage II and III colon cancer, 490 patients were categorized into groups based on 1-6, 7-11, 12-19, and ≥ 20 LNs collected. Results For patients with Stage II or III disease, examination of 12 LNs was not significantly associated with recurrence or mortality. For Stage II (HR = 0.33; 95% CI, 0.12-0.91, but not for Stage III patients (HR = 1.59; 95% CI, 0.54-4.64, examination of ≥20 LNs was associated with a reduced risk of recurrence within 2 years. However, examination of ≥20 LNs had a 55% (Stage II, HR = 0.45; 95% CI, 0.23-0.87 and a 31% (Stage III, HR = 0.69; 95% CI, 0.38-1.26 decreased risk of mortality, respectively. For each six additional LNs examined from Stage III patients, there was a 19% increased probability of finding a positive LN (parameter estimate = 0.18510, p Conclusions Thus, the 12 LN cut-off point cannot be supported as requisite in determining adequate staging of colon cancer based on current data. However, a minimum of 6 LNs should be examined for adequate staging of Stage II and III colon cancer patients.

  19. Nephrolithiasis-induced end stage renal disease

    Directory of Open Access Journals (Sweden)

    M Ounissi

    2010-03-01

    Full Text Available M Ounissi¹, T Gargueh², M Mahfoudhi¹, K Boubaker¹, H Hedri¹, R Goucha¹, E Abderrahim¹, F Ben Hamida¹, T Ben Abdallah¹, F El Younsi¹, H Ben Maiz³, A Kheder¹1Internal Medicine Department, 2Pediatric Department, 3Laboratory of Kidney Diseases, Charles Nicolle Hospital, Tunis, TunisiaIntroduction: Nephrolithiasis still remains a too frequent and underappreciated cause of end stage renal disease (ESRD.Methods and patients: Of the entire cohort of 7128 consecutive patients who started maintenance dialysis in our nephrology department between January 1992 and December 2006, a total of 45 patients (26 women, 19 men had renal stone disease as the cause of ESRD. The type of nephrolithiasis was determined in 45 cases and etiology in 42. The treatment and evolution of stone disease and patient’s survival were studied.Results: The overall proportion of nephrolithiasis related ESRD was 0.63%. The mean age was 48.4 years. Infection stones (struvite accounted for 40%, calcium stones, 26.67% (primary hyperparathyroidism:15.56%; familial hypercalciuria: 4.44%, unknown etiology: 6.66%, primary hyperoxaluria type 1, 17.78% and uric acid lithiasis in 15.56% of cases. The mean delay of the evolution of the stone renal disease to chronic renal failure was 85.8 months. The feminine gender, obesity and elevated alkaline phosphatases >128 IU/L were significantly correlated with fast evolution of ESRD. The median evolution to ESRD was 12 months. The normal body mass index (BMI, medical treatment of stone and primary hyperoxaluria type 1 were correlated with fast evolution to ESRD. All patients were treated by hemodialysis during a mean evolution of 60 months. Sixteen patients died. The patient's survival rate at 1, 3 and 5 years was 97.6, 92.8 and 69% respectively. Hypocalcemia, cardiopathy and normal calcium-phosphate product were significantly correlated with lower survival rate.Conclusion: Severe forms of nephrolithiasis remain an underestimated cause of

  20. Hybrid staging of geothermal energy conversion processes

    Energy Technology Data Exchange (ETDEWEB)

    Steidel, R.F.

    1978-09-01

    A hybrid system consists of two or more energy conversion processes. This study examines the use of three energy conversion machines in hybrid systems: the conventional single-phase turbine, and the two-phase expanders known as the Lysholm engine and the radial outflow reaction turbine. Two hybrid systems are presented. The first is a two-stage, single-flash system with the Lysholm engine as the first stage, and a separator and conventional turbine as the second stage. The second system adds a radial outflow reaction turbine to recover a part of the energy rejected in the second stage. A theoretical specific power of 41.3 kW.s/lb is predicted for the two-stage, single-flash hybrid system. The addition of the radial outflow rotary turbine increases performance to 44.8 kW.s/lb. Both are superior to the double-flash system, with a specific power of 37.8 kW.s/lb. In addition, the hybrid system offers operating flexibility.

  1. A quantification model for apoptosis in mouse embryos in the early stage of fetation

    Institute of Scientific and Technical Information of China (English)

    WANG PengFei; FU JianHua; MA WanYun; CHEN DieYan; Lü DanYu; BAI WenJia

    2009-01-01

    Apoptosis is the most important inducement and modulator for embryos in the early stage of fetation, i.e. after the 8-cell stage, mostly the morula and blastula stage, to proceed to the stage of nonlinear development. Using a two-photon laser scanning microscopy (TPLSM) system, we obtained 3-dimensional (3D) fluorescent images of preimplantation mouse embryos. A model for quantification was established. The statistical results for the spatial location of apoptosis bodies in embryos was obtained following image processing, as well as investigation of the kinetics of apoptosis. It was found that most (70%) apoptosis occurred in the trophectoderm, and the departure between the centroid and geometric center of embryos had a step transition when embryos developed into the 32-cell stage,which was consistent with the theoretical prediction that the blastocele would induce a symmetry break of the distribution of cells in embryos.

  2. A quantification model for apoptosis in mouse embryos in the early stage of fetation

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    Apoptosis is the most important inducement and modulator for embryos in the early stage of fetation, i.e. after the 8-cell stage, mostly the morula and blastula stage, to proceed to the stage of nonlinear development. Using a two-photon laser scanning microscopy (TPLSM) system, we obtained 3-dimensional (3D) fluorescent images of preimplantation mouse embryos. A model for quantification was established. The statistical results for the spatial location of apoptosis bodies in embryos was obtained following image processing, as well as investigation of the kinetics of apoptosis. It was found that most (70%) apoptosis occurred in the trophectoderm, and the departure between the centroid and geometric center of embryos had a step transition when embryos developed into the 32-cell stage, which was consistent with the theoretical prediction that the blastocele would induce a symmetry break of the distribution of cells in embryos.

  3. A CENTRAL-STAGE BUFFERED THREE-STAGE CLOS SWITCHING FABRIC AND THE SCHEDULING ALGORITHM

    Institute of Scientific and Technical Information of China (English)

    Hu Yuxiang; Ma Xiangjie; Lan Julong; Wang Haoxue

    2009-01-01

    Current MSM switching fabric has poor performance under unbalanced traffic. This paper presents an alternative, novel Central-stage Buffered Three-stage Clos switching (CB-3Clos) fabric and proves that this fabric can emulate output queuing switch without any speedup. By analyzing the condition to satisfy the central-stage load-balance, this paper also proposes a Central-stage Load-balanced-based Distributed Scheduling algorithm (CLDS) for CB-3Clos. The results show that, compared with Concurrent Round-Robin based Dispatching (CRRD) algorithm based on MSM, CLDS algorithm has high throughput irrespective with the traffic model and better performance in mean packet delay.

  4. Location and cellular stages of NK cell development

    Science.gov (United States)

    Yu, Jianhua; Freud, Aharon G.; Caligiuri, Michael A

    2013-01-01

    The identification of distinct tissue-specific natural killer (NK) cell populations that apparently mature from local precursor populations has brought new insight into the diversity and developmental regulation of this important lymphoid subset. NK cells provide a necessary link between the early (innate) and late (adaptive) immune responses to infection. Gaining a better understanding of the processes that govern NK cell development should allow us to better harness NK cell functions in multiple clinical settings as well as to gain further insight into how these cells undergo malignant transformation. In this review, we summarize recent advances in understanding sites and cellular stages of NK cell development in humans and mice. PMID:24055329

  5. Reproductive and early life stages pathology - Histopathology workshop report

    Science.gov (United States)

    Bruno, D.W.; Nowak, B.; Elliott, D.G.

    2006-01-01

    Pathology occurring during reproduction and larval development represents an important part of the life cycle of fish, and the diseases that affect eggs and larvae often result in significant losses. However, mortality during this period is frequently ignored or poorly researched as the temptation is to replace the losses rather than investigate the causes. A histopathology workshop organised at the newly refurnished laboratory within the Danish Veterinary School was an opportunity to discuss the pathology of selected diseases associated with Reproductive and Early Life Stages Pathology. Several people also kindly provided reference slides.

  6. Finding a Style for Presenting Shakespeare on the Japanese Stage

    Directory of Open Access Journals (Sweden)

    Minami Ryuta

    2016-12-01

    Full Text Available Japanese productions of Shakespeare’s plays are almost always discussed with exclusive focus upon their visual, musical and physical aspects without any due considerations to their verbal elements. Yet the translated texts in the vernacular, in which most of Japanese stage performances of Shakespeare are given, have played crucial part in understanding and analysing them as a whole. This paper aims to illuminate the importance of the verbal styles and phraseology of Shakespeare’s translated texts by analysing Nakayashiki Norihito’s all-female productions of Hamlet (2011 and Macbeth (2012 in the historical contexts of Japanese Shakespeare translation.

  7. Stagering: Een ontwikkelingspuzzel [The challenge of staging developmental disorders

    NARCIS (Netherlands)

    Gaag, R.J. van der; Wijngaarden-Cremers, P.J. van; Staal, W.G.

    2012-01-01

    BACKGROUND: On the basis of our current knowledge, developmental disorders can be divided into the following stages: stage 0: normal variation, stage 1: simple disorder of moderate severity, stage 2: complicating co-morbidity and/or harmful background circumstances, and stage 3: serious disorder wit

  8. Time-Limited Psychotherapy: An Interactional Stage Model.

    Science.gov (United States)

    Tracey, Terence J.

    One model of successful time-limited psychotherapy characterizes the therapy as a movement through three interactional stages: the early rapport attainment stage, the middle conflict stage, and the final resolution stage. According to this model, these stages are indicated by the relative presence of communicational harmony. To examine the…

  9. Stages of Behavioral Change for Reducing Sodium Intake in Korean Consumers: Comparison of Characteristics Based on Social Cognitive Theory.

    Science.gov (United States)

    Ahn, So-Hyun; Kwon, Jong Sook; Kim, Kyungmin; Kim, Hye-Kyeong

    2017-07-27

    High sodium intake increases the risk of cardiovascular disease. Given the importance of behavioral changes to reducing sodium intake, this study aims to investigate the stages of change and the differences in cognitive and behavioral characteristics by stage in Korean consumers. Adult participants (N = 3892) completed a questionnaire on the stages of behavioral change, recognition of social efforts, outcome expectancy, barriers to practice, nutrition knowledge and dietary behaviors, and self-efficiency related to reduced sodium intake. The numbers of participants in each stage of behavioral change for reducing sodium intake was 29.5% in the maintenance stage, 19.5% in the action stage, and 51.0% in the preaction stage that included the precontemplation, contemplation, and preparation stages. Multiple logistic regression showed that the factors differentiating the three stages were recognizing a supportive social environment, perceived barriers to the practice of reducing sodium intake, and self-efficacy to be conscious of sodium content and to request less salt when eating out. Purchasing experience of sodium-reduced products for salty foods, knowledge of the recommended intake of salt and the difference between sodium and salt, and improving dietary habits of eating salted fish, processed food, and salty snacks were factors for being in the action stage versus the preaction stage. These findings suggest that tailored intervention according to the characteristics of each stage is helpful in reducing sodium intake.

  10. Stages of Behavioral Change for Reducing Sodium Intake in Korean Consumers: Comparison of Characteristics Based on Social Cognitive Theory

    Science.gov (United States)

    Ahn, So-hyun; Kwon, Jong Sook; Kim, Kyungmin; Kim, Hye-Kyeong

    2017-01-01

    High sodium intake increases the risk of cardiovascular disease. Given the importance of behavioral changes to reducing sodium intake, this study aims to investigate the stages of change and the differences in cognitive and behavioral characteristics by stage in Korean consumers. Adult participants (N = 3892) completed a questionnaire on the stages of behavioral change, recognition of social efforts, outcome expectancy, barriers to practice, nutrition knowledge and dietary behaviors, and self-efficiency related to reduced sodium intake. The numbers of participants in each stage of behavioral change for reducing sodium intake was 29.5% in the maintenance stage, 19.5% in the action stage, and 51.0% in the preaction stage that included the precontemplation, contemplation, and preparation stages. Multiple logistic regression showed that the factors differentiating the three stages were recognizing a supportive social environment, perceived barriers to the practice of reducing sodium intake, and self-efficacy to be conscious of sodium content and to request less salt when eating out. Purchasing experience of sodium-reduced products for salty foods, knowledge of the recommended intake of salt and the difference between sodium and salt, and improving dietary habits of eating salted fish, processed food, and salty snacks were factors for being in the action stage versus the preaction stage. These findings suggest that tailored intervention according to the characteristics of each stage is helpful in reducing sodium intake. PMID:28749441

  11. Life stages: interactions and spatial patterns.

    Science.gov (United States)

    Robertson, Suzanne L; Cushing, J M; Costantino, R F

    2012-02-01

    In many stage-structured species, different life stages often occupy separate spatial niches in a heterogeneous environment. Life stages of the giant flour beetle Tribolium brevicornis (Leconte), in particular adults and pupae, occupy different locations in a homogeneous habitat. This unique spatial pattern does not occur in the well-studied stored grain pests T. castaneum (Herbst) and T. confusum (Duval). We propose density dependent dispersal as a causal mechanism for this spatial pattern. We model and explore the spatial dynamics of T. brevicornis with a set of four density dependent integrodifference and difference equations. The spatial model exhibits multiple attractors: a spatially uniform attractor and a patchy attractor with pupae and adults spatially separated. The model attractors are consistent with experimental observations.

  12. STAGING OF FUEL CELLS - PHASE II

    Energy Technology Data Exchange (ETDEWEB)

    Per Onnerud; Suresh Sriramulu

    2002-08-29

    TIAX has executed a laboratory-based development program aiming at the improvement of stationary fuel cell systems. The two-year long development program resulted in an improved understanding of staged fuel cells and inorganic proton conductors through evaluation of results from a number of laboratory tasks: (1) Development of a fuel cell modeling tool--Multi-scale model was developed, capable of analyzing the effects of materials and operating conditions; and this model allowed studying various ''what-if'' conditions for hypothetically staged fuel cells; (2) Study of new high temperature proton conductor--TIAX discovery of a new class of sulfonated inorganics capable of conducting protons when exposed to water; and study involved synthesis and conductivity measurements of novel compounds up to 140 C; (3) Electrochemical fuel cell measurements--the feasibility of staged fuel cells was tested in TIAX's fuel cell laboratories experimental design was based on results from modeling.

  13. Imaging the earliest stages of Alzheimer's disease.

    Science.gov (United States)

    Wu, William; Small, Scott A

    2006-12-01

    Historical progress in medicine can be charted along the lines of technical innovations that have visualized the invisible. One hundred years ago, Alois Alzheimer exploited newly developed histological stains to visualize his eponymonous disease in dead tissue under the microscope. Now, as we are entering the second century of Alzheimer's disease research, technical innovation has endowed us with a range of in vivo imaging techniques that promise to visualize Alzheimer' disease in living people. The earliest stage of Alzheimer's disease is characterized by cell-sickness, not cell-death, and can occur before the deposition of amyloid plaques or neurofibrillary tangles. In principle, 'functional' imaging techniques might be able to detect this early stage of the disease, a stage that was invisible to Alzheimer himself. Here, we will first define the neurobiological meaning of 'function' and then review the different approaches that measure brain dysfunction in Alzheimer' disease.

  14. Radiation therapy for stage IVA cervical cancer.

    Science.gov (United States)

    Murakami, Naoya; Kasamatsu, Takahiro; Morota, Madoka; Sumi, Minako; Inaba, Koji; Ito, Yoshinori; Itami, Jun

    2013-11-01

    To evaluate the outcome and discover predictive factors for patients with stage IVA cervical cancer treated with definitive radiation therapy. We retrospectively reviewed 34 patients with stage IVA cervical cancer who received definitive radiation therapy between 1992 and 2009. On univariate analysis, statistically significant prognostic factors for improved local control rate (LCR) were absence of pyometra (p=0.037) and equivalent dose in 2 Gy fractions (EQD2) at point A greater than 60 Gy (p=0.023). Prognostic factors for improved progression-free survival (PFS) were absence of pelvic lymph node metastasis at initial presentation (p=0.014), and EQD2 at point A greater than 60 Gy (p=0.023). Patients with stage IVA disease had poor median survival. However adequate radiation dose to point A produced favorable LCR and PFS, therefore efforts should be made to increase the point A dose.

  15. Electric energy consumption in the cotton textile processing stages

    Energy Technology Data Exchange (ETDEWEB)

    Palamutcu, S. [Textile Engineering Department, Pamukkale University, Engineering Faculty, 20070 Kinikli, Denizli (Turkey)

    2010-07-15

    Electric energy is one of the primary energy sources consumpted in cotton textile processing. Current energy cost rate is reported about 8-10% in the total production cost of an ordinary textile product manufactured in Turkey. Significantly important share of this energy cost is electric energy. The aim of this paper was to investigate unit electric energy consumption of cotton textile processing stages using real-time measurements method. Actual and estimated Specific Energy Consumption (SEC) values for electric energy was calculated in the cotton textile processing stages of spinning, warping-sizing, weaving, wet processing and clothing manufacturing. Actual electric energy consumption data are gathered from monthly records of the involved plant managements. Estimated electric energy consumption data is gathered through on-site measurement. Actual and estimated electric energy consumption data and monthly production quantities of the corresponding months are used to facilitate specific electric energy consumption of the plants. It is found that actual electric energy consumption amount per unit textile product is higher than the estimated electric energy consumption amount per unit textile product of each involved textile processing stages. (author)

  16. Second primary cancer in irradiated stage I testicular seminoma

    Energy Technology Data Exchange (ETDEWEB)

    Stein, M.E. (Northern Israel Oncology Center, Rambam Medical Center, Haifa (Israel)); Steiner, M. (Northern Israel Oncology Center, Rambam Medical Center, Haifa (Israel)); Lachter, J. (Dept. of Internal Medicine, The Bruce Rappaport Faculty of Medicine,Technicon-Israel Inst. of Technology, Haifa (Israel)); Kessel, I. (Rand Clinic, Johannesburg (South Africa). Dept. of Radiotherapy); Moskovitz, B. (Dept. of Urology, Bnai-Zion Medical Center, Haifa (Israel)); Kuten, A. (Northern Israel Oncology Center, Rambam Medical Center, Haifa (Israel))

    1993-11-01

    The incidence of second primary cancer (SPC) was determined in 64 irradiated stage I testicular seminoma patients, treated and followed at the Northern Israel Oncology Center from 1968 to 1988. Seven (11%) patients developed a total of eight second cancers. The cumulative risk for developing second primary cancer at ten, 15 and 20 years following the diagnosis of seminoma was 2.5%, 5.1% and 8.9%, respectively. Two patients developed SPC within the radiation field (urinary bladder, sigmoid colon) and four patients outside the radiation field (bronchogenic cancer, thymoma, malignant melanoma, thyroid cancer). In two patients, who developed lung cancer and testicular seminoma, respectively, scatter dose from the main radiation field could not be excluded as one of the factors contributing to the SPC. Three patients died as a direct result of their SPC. It is concluded that there is a low, but significant risk of solid SPC among patients apparently cured of early stage seminoma. It will be important in future surveillance studies of stage I seminoma to assess the risk of SPC in the non-irradiated patients. (orig.)

  17. Numerical Simulation of Multi-Stage Turbomachinery Flows

    Science.gov (United States)

    Adamczyk, John J.; Hathaway, Michael D.; Shabbir, Aamir; Wellborn, Steven R.

    1999-01-01

    A comprehensive assessment is made of the predictive capability of the average passage flow model as applied to multi-stage axial flow compressors. The average passage flow model describes the time average flow field within a typical passage of a blade row embedded in a multi-stage configuration. In this work data taken within a four and one-half stage large low speed compressor will be used to assess the weakness and strengths of the predictive capabilities of the average passage flow model. The low speed compressor blading is of modern design and employs stators with end-bends. Measurements were made with slow and high response instrumentation. The high response measurements revealed the velocity components of both the rotor and stator wakes. Based on the measured wake profiles it will be argued that blade boundary layer transition is playing an important role in setting compressor performance. A model which mimics the effects of blade boundary layer transition within the frame work of the average passage model will be presented. Simulations which incorporated this model showed a dramatic improvement in agreement with data.

  18. Complement in different stages of HIV infection and pathogenesis.

    Science.gov (United States)

    Speth, Cornelia; Stoiber, Heribert; Dierich, Manfred P

    2003-04-01

    The complement system is one of the most important weapons of innate immunity and is involved in all infectious processes. It is not only a mechanism for direct protection against an invading pathogen but it also interacts with the adaptive immunity to optimize the pathogen-specific humoral and cellular defence cascade in the body. One of the greatest challenges for the complement system is infection by HIV with its chronic course and sequential destruction of immune cells and immune organs. Due to its dual role as direct effector and as fine tuner of adaptive immunity, we focussed on complement in this review and analysed in detail the contribution of complement to the antiviral defence and to HIV pathogenesis on the one hand and the complement evasion strategies of the virus on the other hand. In the present review, this interplay between complement and the virus is illuminated for the three different stages of HIV pathogenesis and for events during therapy: (1) the acute infection process with the early events in mucosa and serum; (2) the asymptomatic stage with the complex interplay between complement-induced lysis and viral evasion strategies; (3) the symptomatic infection and AIDS stage with progressive destruction of the lymph nodes, opportunistic infections and development of neuropathogenesis, and (4) finally, during highly active antiretroviral therapy and in vaccination approaches. Copyright 2003 S. Karger AG, Basel

  19. The difficult early stages of embedded star clusters and the importance of the pre-gas expulsion virial ratio

    OpenAIRE

    Farias, J. P.; Smith, R; Fellhauer, M.; Goodwin, S.; Candlish, G. N.; Blaña, M.; R. Dominguez

    2015-01-01

    We examine the effects of gas-expulsion on initially substructured distributions of stars. We perform N-body simulations of the evolution of these distributions in a static background potential to mimic the gas. We remove the static potential instantaneously to model gas-expulsion. We find that the exact dynamical state of the cluster plays a very strong role in affecting a cluster's survival, especially at early times: they may be entirely destroyed or only weakly affected. We show that know...

  20. Cyclooxygenase activity is important for efficient replication of mouse hepatitis virus at an early stage of infection

    NARCIS (Netherlands)

    Raaben, Matthijs; Einerhand, Alexandra W. C.; Taminiau, Lucas J. A.; van Houdt, Michel; Bouma, Janneke; Raatgeep, Rolien H.; Buller, Hans A.; de Haan, Cornelis A. M.; Rossen, John W. A.

    2007-01-01

    Cyclooxygenases (COXs) play a significant role in many different viral infections with respect to replication and pathogenesis. Here we investigated the role of COXs in the mouse hepatitis coronavirus (MHV) infection cycle. Blocking COX activity by different inhibitors or by RNA interference affecte

  1. Importance of virological response in the early stage of telaprevir-based triple therapy for hepatitis C

    Institute of Scientific and Technical Information of China (English)

    Satoshi; Hiramine; Norihiro; Furusyo; Eiichi; Ogawa; Makoto; Nakamuta; Eiji; Kajiwara; Hideyuki; Nomura; Kazufumi; Dohmen; Kazuhiro; Takahashi; Takeaki; Satoh; Koichi; Azuma; Akira; Kawano; Toshimasa; Koyanagi; Kazuhiro; Kotoh; Shinji; Shimoda; Jun; Hayashi

    2015-01-01

    AIM: To investigate the efficacy of virological response(VR) to telaprevir(TVR)-based triple therapy in predicting treatment outcome of hepatitis C.METHODS: This prospective, multicenter study consisted of 253 Japanese patients infected with hepatitis C virus(HCV) genotype 1b. All received 12 wk of TVR in combination with 24 wk of pegylatedinterferon-α(IFN-α) and ribavirin. Serum HCV RNA was tested at weeks 1, 2, 3, 4, 6, 8, 12, 16, 20, and 24. VR was defined as undetectable serum HCV RNA. Sustained virological response(SVR) was VR at 24 wk after the end of treatment and was regarded as a successful outcome.RESULTS: Of 253 patients, 207(81.8%) achieved SVR. The positive predictive value of VR for SVR was 100% at week 2, after which it gradually decreased, and was over 85% to week 12. The negative predictive value(NPV) gradually increased, reaching 100% at week 12. The upslope of the NPV showed a large increase from week 4(40.6%) to week 6(82.4%). There was a moderate concordance between the SVR and VR at week 6(kappa coefficient = 0.44), although other VRs had poor concordance to SVR. Multiple logistic regression analysis extracted VR at week 6(P < 0.0001, OR = 63.8) as an independent factor contributing to SVR. In addition, the interleukin-28 B single nucleotide polymorphism and response to previous pegylated-IFN-α and ribavirin therapy were identified as independent factors for SVR.CONCLUSION: VR at week 6, but not at week 4, is an efficient predictor of both SVR and non-SVR to TVRbased triple therapy.

  2. SEARCH OF A TEAM LEADER AS THE MOST IMPORTANT STAGE IN THE FORMATION OF THE MANAGEMENT TEAM

    Directory of Open Access Journals (Sweden)

    Yan Vladimirovich Fedosyuk

    2015-01-01

    Full Text Available The article describes the characteristics of the management team and team leader, formulates the key criteria for identification and approval of the team leader. To build an effective management team it is necessary to understand the principles of identification and approval of the leader, the ways to improve his skills and personal characteristics. After a thorough analysis of domestic and foreign literature, the author identifies the key points of leadership and teambuilding in general. A separate issue is understanding of differences between a formal leader and informal leader and proper use of these structural units, what is also highlighted in the article. The article is addressed to managers of small and medium businesses facing the challenge of creating a capable and fully functioning team of specialists for long-term work. The article highlights different theories and classifications of leadership, identifies similar and alternative factors, and provides final recommendations to the process of searching for a leader.

  3. The difficult early stages of embedded star clusters and the importance of the pre-gas expulsion virial ratio

    CERN Document Server

    Farias, J P; Fellhauer, M; Goodwin, S; Candlish, G N; Blaña, M; Dominguez, R

    2015-01-01

    We examine the effects of gas-expulsion on initially substructured distributions of stars. We perform N-body simulations of the evolution of these distributions in a static background potential to mimic the gas. We remove the static potential instantaneously to model gas-expulsion. We find that the exact dynamical state of the cluster plays a very strong role in affecting a cluster's survival, especially at early times: they may be entirely destroyed or only weakly affected. We show that knowing both detailed dynamics and relative star-gas distributions can provide a good estimate of the post-gas expulsion state of the cluster, but even knowing these is not an absolute way of determining the survival or otherwise of the cluster.

  4. An Important Stage of Life-Long Learning: Adult Literacy and Benefits (Sampling of Kayseri in Turkey)

    Science.gov (United States)

    Göçer, Ali

    2016-01-01

    The purpose of this research is to provide an overview of adult literacy within the framework of lifelong learning in Turkey. Triangulation technique is applied with the approach of qualitative research, and within this framework, document review, interviews and observations were made. The research was carried out in a workgroup. These working…

  5. US youths in the early stages of HIV disease have low intakes of some micronutrients important for optimal immune function.

    Science.gov (United States)

    Kruzich, Laurie A; Marquis, Grace S; Carriquiry, Alicia L; Wilson, Craig M; Stephensen, Charles B

    2004-07-01

    We examined the association between micronutrient intakes and human immunodeficiency virus (HIV) infection in youths who were at increased nutritional risk because of the demands of growth and disease as well as poor dietary habits. This was a cross-sectional study to collect dietary intake data using the Block Food Frequency Questionnaire (98.2). Anthropometric, biochemical, clinical, and sociodemographic data were available.Subjects/Setting Participants included 264 HIV-infected and 127 HIV-uninfected adolescents and young adults from the Reaching for Excellence in Adolescent Care and Health network, a multisite observational study on HIV progression. Statistical analyses CD4(+) T cells were stratified for HIV-infected youths: >/=500, 200 to 499, and /=500 cells/microL. After controlling for other factors, HIV-infected participants with CD4(+) T cells >/=500 had decreased iron intake (P<.05) and tended to be associated with lower intakes of vitamins C and E (P<.10) compared with those with more advanced disease and HIV-uninfected youths. Among those youths with CD4(+) T cells between 200 and 499 cells/microL, a high anxiety score was associated with a sixfold increase in vitamin A intake as compared with those with a low score.Applications/conclusions Given the increased micronutrient requirements, nutrition counseling with HIV-infected youths should focus on early increase of intake of foods rich in micronutrients to improve growth, slow disease progression, and increase survival.

  6. The Mark of Importance in Industry Portuguese Moulds

    Directory of Open Access Journals (Sweden)

    Rui Estrela

    2014-12-01

    Full Text Available The recent creation of a collective brand to promote the Portuguese tooling cluster in international markets such as value appropriation half highlights the need to understand how important brand for Portuguese companies. This implies ascertain what the position that the brand is taking in customers' minds as well as their degree of notoriety and recognition. This study aims to analyze the importance of brand for the various cluster stakeholders, including businesses, educational institutions and research and development, suppliers, associations and customers. As this study at an early stage of implementation of the mark 'Engineering & Tooling from Portugal "it appears that this is seen as an important factor in the competitiveness of Portuguese companies, despite the brand recognition level is still reducing. This work also seeks to provide guidance to enable the cluster to maximize brand value, we propose the strengthening of the promotion plan and the targeting of key brand attributes. Corporate Social; Image tag. 

  7. Psychosexual Intervention in Patients With Stage I-III Gynecologic or Breast Cancer

    Science.gov (United States)

    2016-05-02

    Ovarian Sarcoma; Ovarian Stromal Cancer; Stage I Uterine Sarcoma; Stage I Vaginal Cancer; Stage I Vulvar Cancer; Stage IA Cervical Cancer; Stage IA Endometrial Carcinoma; Stage IA Fallopian Tube Cancer; Stage IA Ovarian Epithelial Cancer; Stage IA Ovarian Germ Cell Tumor; Stage IA Primary Peritoneal Cavity Cancer; Stage IB Cervical Cancer; Stage IB Endometrial Carcinoma; Stage IB Fallopian Tube Cancer; Stage IB Ovarian Epithelial Cancer; Stage IB Ovarian Germ Cell Tumor; Stage IB Primary Peritoneal Cavity Cancer; Stage IC Fallopian Tube Cancer; Stage IC Ovarian Epithelial Cancer; Stage IC Ovarian Germ Cell Tumor; Stage IC Primary Peritoneal Cavity Cancer; Stage II Endometrial Carcinoma; Stage II Gestational Trophoblastic Tumor; Stage II Uterine Sarcoma; Stage II Vaginal Cancer; Stage II Vulvar Cancer; Stage IIA Cervical Cancer; Stage IIA Fallopian Tube Cancer; Stage IIA Ovarian Epithelial Cancer; Stage IIA Ovarian Germ Cell Tumor; Stage IIA Primary Peritoneal Cavity Cancer; Stage IIB Cervical Cancer; Stage IIB Fallopian Tube Cancer; Stage IIB Ovarian Epithelial Cancer; Stage IIB Ovarian Germ Cell Tumor; Stage IIB Primary Peritoneal Cavity Cancer; Stage IIC Fallopian Tube Cancer; Stage IIC Ovarian Epithelial Cancer; Stage IIC Ovarian Germ Cell Tumor; Stage IIC Primary Peritoneal Cavity Cancer; Stage III Gestational Trophoblastic Tumor; Stage III Uterine Sarcoma; Stage III Vaginal Cancer; Stage III Vulvar Cancer; Stage IIIA Cervical Cancer; Stage IIIA Endometrial Carcinoma; Stage IIIA Fallopian Tube Cancer; Stage IIIA Ovarian Epithelial Cancer; Stage IIIA Ovarian Germ Cell Tumor; Stage IIIA Primary Peritoneal Cavity Cancer; Stage IIIB Cervical Cancer; Stage IIIB Endometrial Carcinoma; Stage IIIB Fallopian Tube Cancer; Stage IIIB Ovarian Epithelial Cancer; Stage IIIB Ovarian Germ Cell Tumor; Stage IIIB Primary Peritoneal Cavity Cancer; Stage IIIC Endometrial Carcinoma; Stage IIIC Fallopian Tube Cancer; Stage IIIC Ovarian Epithelial Cancer; Stage IIIC Ovarian Germ Cell

  8. Stage fright in singers: three reaction types.

    Science.gov (United States)

    Berghs, Geert

    2008-01-01

    Drawing on both my own personal experience and that of many colleagues and pupils, I shall describe three kinds of reactions to stage fright. The first is the primarily mental reaction of derealization, which involves feeling cut off from fear and decreasing body awareness. The second and third reactions to stage fright involve (a) increased and (b) decreased muscle tonus and their associated breathing patterns. Furthermore, I shall indicate how singers manage to pull themselves together through the very act of producing their first tones. Copyright 2008 S. Karger AG, Basel.

  9. Stage- vs. Channel-strip Metaphor

    DEFF Research Database (Denmark)

    Gelineck, Steven; Korsgaard, Dannie Michael; Büchert, Morten

    2015-01-01

    This study compares the stage metaphor and the channel strip metaphor in terms of performance. Traditionally, music mixing consoles employ a channels strip control metaphor for adjusting parameters such as volume and panning of each track. An alternative control metaphor, the so-called stage...... metaphor lets the user adjust volume and panning by positioning tracks relative to a virtual listening position. In this study test participants are given the task to adjust volume and panning of one channel (in mixes consisting of three channels) in order to replicate a series of simple pre-rendered mixes...

  10. An Enhanced Preventive Maintenance Optimization Model Based on a Three-Stage Failure Process

    Directory of Open Access Journals (Sweden)

    Ruifeng Yang

    2015-01-01

    Full Text Available Nuclear power plants are highly complex systems and the issues related to their safety are of primary importance. Probabilistic safety assessment is regarded as the most widespread methodology for studying the safety of nuclear power plants. As maintenance is one of the most important factors for affecting the reliability and safety, an enhanced preventive maintenance optimization model based on a three-stage failure process is proposed. Preventive maintenance is still a dominant maintenance policy due to its easy implementation. In order to correspond to the three-color scheme commonly used in practice, the lifetime of system before failure is divided into three stages, namely, normal, minor defective, and severe defective stages. When the minor defective stage is identified, two measures are considered for comparison: one is that halving the inspection interval only when the minor defective stage is identified at the first time; the other one is that if only identifying the minor defective stage, the subsequent inspection interval is halved. Maintenance is implemented immediately once the severe defective stage is identified. Minimizing the expected cost per unit time is our objective function to optimize the inspection interval. Finally, a numerical example is presented to illustrate the effectiveness of the proposed models.

  11. Type II fatty acid synthesis is essential only for malaria parasite late liver stage development

    OpenAIRE

    Vaughan, Ashley M.; O'Neill, Matthew T.; Tarun, Alice S.; Camargo, Nelly; Phuong, Thuan M; Aly, Ahmed S I; Cowman, Alan F.; Kappe, Stefan H. I.

    2008-01-01

    Intracellular malaria parasites require lipids for growth and replication. They possess a prokaryotic type II fatty acid synthesis (FAS II) pathway that localizes to the apicoplast plastid organelle and is assumed to be necessary for pathogenic blood stage replication. However, the importance of FAS II throughout the complex parasite life cycle remains unknown. We show in a rodent malaria model that FAS II enzymes localize to the sporozoite and liver stage apicoplast. Targeted deletion of Fab...

  12. Cell wall chemical characteristics of whole‐crop cereal silages harvested at three maturity stages

    OpenAIRE

    Wallsten, Johanna; Hatfield, Ronald

    2016-01-01

    Abstract Background In cooler climates such as found in Scandinavian countries cereals are important feedstuffs for ruminants often ensiled as whole‐crop cereal silages (WCCS) to preserve nutrients. Animal performance varies with the type of cereal forage and stage of cereal development being ensiled. Cell wall isolation and analysis was undertaken to determine differences among cereal silages harvested at different stages of maturity. Results A set of 27 WCCS samples of barley, wheat and oat...

  13. Identification of 42 Genes Linked to Stage II Colorectal Cancer Metastatic Relapse

    OpenAIRE

    2016-01-01

    Colorectal cancer (CRC) is one of the leading causes of cancer mortality. Metastasis remains the primary cause of CRC death. Predicting the possibility of metastatic relapse in early-stage CRC is of paramount importance to target therapy for patients who really need it and spare those with low-potential of metastasis. Ninety-six stage II CRC cases were stratified using high-resolution array comparative genomic hybridization (aCGH) data based on a predictive survival algorithm and supervised c...

  14. The effect on esophagus after different radiotherapy techniques for early stage Hodgkin's lymphoma

    DEFF Research Database (Denmark)

    Jørgensen, Anni; Maraldo, M.; Brodin, Nils Patrik

    2013-01-01

    The cure rate of early stage Hodgkin's lymphoma (HL) is excellent; investigating the late effects of treatment is thus important. Esophageal toxicity is a known side effect in patients receiving radiotherapy (RT) to the mediastinum, although little is known of this in HL survivors. This study inv...... investigates the dose to the esophagus in the treatment of early stage HL using different RT techniques. Estimated risks of early esophagitis, esophageal stricture and cancer are compared between treatments....

  15. Modeling river dune development and dune transition to upper stage plane bed

    OpenAIRE

    Naqshband, S.; Duin, van, W.E.; Ribberink, J.S.; Hulscher, S.J.M.H.

    2016-01-01

    Large asymmetric bedforms known as dunes commonly dominate the bed of sand rivers. Due to the turbulence generation over their stoss and lee sides, dunes are of central importance in predicting hydraulic roughness and water levels. During floods in steep alluvial rivers, dunes are observed to grow rapidly as flow strength increases, undergoing an unstable transition regime, after which they are washed out in what is called upper stage plane bed. This transition of dunes to upper stage plane b...

  16. Phosphoproteome dynamics reveal heat-shock protein complexes specific to the Leishmania donovani infectious stage

    OpenAIRE

    Morales, M. A.; R. WATANABE; Dacher, M.; Chafey, P.; Osorio y Fortea, J.; Scott, D A; Beverley, S. M.; van Ommen, G.; CLOS, J.; Hem, S.; Lenormand, P.; Rousselle, J.-C.; Namane, A.; Spath, G. F.

    2010-01-01

    Leishmania is exposed to a sudden increase in environmental temperature during the infectious cycle that triggers stage differentiation and adapts the parasite phenotype to intracellular survival in the mammalian host. The absence of classical promoter-dependent mechanisms of gene regulation and constitutive expression of most of the heat-shock proteins (HSPs) in these human pathogens raise important unresolved questions as to regulation of the heat-shock response and stage-specific functions...

  17. A novel FIKK kinase regulates the development of mosquito and liver stages of the malaria

    OpenAIRE

    Jaijyan, Dabbu Kumar; Verma, Praveen Kumar; Singh, Agam Prasad

    2016-01-01

    Protein phosphorylation is the most important post-translational event in the regulation of various essential signaling pathways in a cell. Here, we show the functional characterization of a FIKK family protein kinase of the rodent malaria parasite (PbMLFK), which is expressed only in mosquito and liver stages and contains two functional C-terminal PEXEL motifs. We demonstrate that this protein plays a role in mosquito and liver stages of parasite growth. The oocysts of PbMLFK-deficient paras...

  18. Evaluation of a prognostic model for risk of relapse in stage I seminoma surveillance

    DEFF Research Database (Denmark)

    Chung, Peter; Daugaard, Gedske; Tyldesley, Scott

    2015-01-01

    A prognostic model for relapse risk in stage I seminoma managed by surveillance after orchiectomy has been developed but has not been independently validated. Individual data on 685 stage I seminoma surveillance patients managed between 1998 and 2005 at three cancer centers were retrospectively...... useful, highly discriminating prognostic model remains elusive in stage I seminoma surveillance as we were unable to validate the previously developed model. However, primary tumor size retained prognostic importance and a scale of relapse risk based on the unit increment of tumor size was developed...

  19. SOX9 Expression Predicts Relapse of Stage II Colon Cancer Patients

    DEFF Research Database (Denmark)

    Espersen, Maiken Lise Marcker; Linnemann, Dorte; Alamili, Mahdi;

    2016-01-01

    The aim of this study was to investigate if the protein expression of Sex-determining region y-box 9 (SOX9) in primary tumors could predict relapse of stage II colon cancer patients.144 patients with stage II primary colon cancer were retrospectively enrolledin the study. SOX9 expression...... high levels of SOX9 of primary stage II colon tumors predict low riskof relapse whereas low levels of SOX9 predict high risk of relapse. SOX9 may have an important value as a biomarker when evaluating risk of relapse for personalized treatment....

  20. Proteomic analysis of the cyst stage of Entamoeba histolytica.

    Directory of Open Access Journals (Sweden)

    Ibne Karim M Ali

    Full Text Available The category B agent of bioterrorism, Entamoeba histolytica has a two-stage life cycle: an infective cyst stage, and an invasive trophozoite stage. Due to our inability to effectively induce encystation in vitro, our knowledge about the cyst form remains limited. This also hampers our ability to develop cyst-specific diagnostic tools.Three main aims were (i to identify E. histolytica proteins in cyst samples, (ii to enrich our knowledge about the cyst stage, and (iii to identify candidate proteins to develop cyst-specific diagnostic tools.Cysts were purified from the stool of infected individuals using Percoll (gradient purification. A highly sensitive LC-MS/MS mass spectrometer (Orbitrap was used to identify cyst proteins.A total of 417 non-redundant E. histolytica proteins were identified including 195 proteins that were never detected in trophozoite-derived proteomes or expressed sequence tag (EST datasets, consistent with cyst specificity. Cyst-wall specific glycoproteins Jacob, Jessie and chitinase were positively identified. Antibodies produced against Jacob identified cysts in fecal specimens and have potential utility as a diagnostic reagent. Several protein kinases, small GTPase signaling molecules, DNA repair proteins, epigenetic regulators, and surface associated proteins were also identified. Proteins we identified are likely to be among the most abundant in excreted cysts, and therefore show promise as diagnostic targets.The proteome data generated here are a first for naturally-occurring E. histolytica cysts, and they provide important insights into the infectious cyst form. Additionally, numerous unique candidate proteins were identified which will aid the development of new diagnostic tools for identification of E. histolytica cysts.

  1. Cross-View Neuroimage Pattern Analysis for Alzheimer's Disease Staging

    Directory of Open Access Journals (Sweden)

    Sidong eLiu

    2016-02-01

    Full Text Available The research on staging of pre-symptomatic and prodromal phase of neurological disorders, e.g., Alzheimer's disease (AD, is essential for prevention of dementia. New strategies for AD staging with a focus on early detection, are demanded to optimize potential efficacy of disease-modifying therapies that can halt or slow the disease progression. Recently, neuroimaging are increasingly used as additional research-based markers to detect AD onset and predict conversion of MCI and normal control (NC to AD. Researchers have proposed a variety of neuroimaging biomarkers to characterize the patterns of the pathology of AD and MCI, and suggested that multi-view neuroimaging biomarkers could lead to better performance than single-view biomarkers in AD staging. However, it is still unclear what leads to such synergy and how to preserve or maximize. In an attempt to answer these questions, we proposed a cross-view pattern analysis framework for investigating the synergy between different neuroimaging biomarkers. We quantitatively analyzed 9 types of biomarkers derived from FDG-PET and T1-MRI, and evaluated their performance in a task of classifying AD, MCI and NC subjects obtained from the ADNI baseline cohort. The experiment results showed that these biomarkers could depict the pathology of AD from different perspectives, and output distinct patterns that are significantly associated with the disease progression. Most importantly, we found that these features could be separated into clusters, each depicting a particular aspect; and the inter-cluster features could always achieve better performance than the intra-cluster features in AD staging.

  2. Proteomic Analysis of the Cyst Stage of Entamoeba histolytica

    Science.gov (United States)

    Ali, Ibne Karim M.; Haque, Rashidul; Siddique, Abdullah; Kabir, Mamun; Sherman, Nicholas E.; Gray, Sean A.; Cangelosi, Gerard A.; Petri, William A.

    2012-01-01

    Background The category B agent of bioterrorism, Entamoeba histolytica has a two-stage life cycle: an infective cyst stage, and an invasive trophozoite stage. Due to our inability to effectively induce encystation in vitro, our knowledge about the cyst form remains limited. This also hampers our ability to develop cyst-specific diagnostic tools. Aims Three main aims were (i) to identify E. histolytica proteins in cyst samples, (ii) to enrich our knowledge about the cyst stage, and (iii) to identify candidate proteins to develop cyst-specific diagnostic tools. Methods Cysts were purified from the stool of infected individuals using Percoll (gradient) purification. A highly sensitive LC-MS/MS mass spectrometer (Orbitrap) was used to identify cyst proteins. Results A total of 417 non-redundant E. histolytica proteins were identified including 195 proteins that were never detected in trophozoite-derived proteomes or expressed sequence tag (EST) datasets, consistent with cyst specificity. Cyst-wall specific glycoproteins Jacob, Jessie and chitinase were positively identified. Antibodies produced against Jacob identified cysts in fecal specimens and have potential utility as a diagnostic reagent. Several protein kinases, small GTPase signaling molecules, DNA repair proteins, epigenetic regulators, and surface associated proteins were also identified. Proteins we identified are likely to be among the most abundant in excreted cysts, and therefore show promise as diagnostic targets. Major Conclusions The proteome data generated here are a first for naturally-occurring E. histolytica cysts, and they provide important insights into the infectious cyst form. Additionally, numerous unique candidate proteins were identified which will aid the development of new diagnostic tools for identification of E. histolytica cysts. PMID:22590659

  3. BIM: Integrating Cost Estimates at Initial/Design Stage

    Directory of Open Access Journals (Sweden)

    Raja Bukhary Raja Taihairan

    2015-10-01

    Full Text Available The accuracy of the cost estimates is very important in the initial stage because it will determine the viability of the project and provide the project budget. Therefore, Inaccuracy of the cost estimates beyond the acceptable range will cause the cost overrun in the later stage. This research aims to recommend BIM to be applied as a part of the cost management process and to improve the cost estimating at the initial/design stage. In addition, this research will investigate the factors influencing the accuracy, why BIM not been applied to reduce the inaccuracy and how BIM can be integrated into cost estimates at the initial / design stage. This research was carried out via literature review, questionnaire survey and semi-structured interview. It was indicated that insufficient information related to the project, poor communication between project team and complexity of design and construction are the three most factors influenced the accuracy of cost estimates. While collaborating and sharing information between the project team, and investment in software and training are the barriers in implementing BIM. The research also found out that BIM is an integrated multi-disciplinary tool that serves architecture, structural and M&E. In addition, the capability of BIM in assisting cost estimates allow QS to focus more value adding activities in estimating such as: identifying construction assemblies, pricing and factoring risks, which are essential for high quality estimates. In conclusion, with the capability of BIM and its integration will help to minimize the error and enhance the project cost estimates in the future.

  4. Effect of Harvesting Stage on Sweet Sorghum (Sorghum bicolor L.) Genotypes in Western Kenya

    Science.gov (United States)

    Owuoche, James O.; Oyoo, Maurice E.; Cheruiyot, Erick; Mulianga, Betty

    2017-01-01

    Harvesting stage of sweet sorghum (Sorghum bicolor L. Moench) cane is an important aspect in the content of sugar for production of industrial alcohol. Four sweet sorghum genotypes were evaluated for harvesting stage in a randomized complete block design. In order to determine sorghum harvest growth stage for bioethanol production, sorghum canes were harvested at intervals of seven days after anthesis. The genotypes were evaluated at different stages of development for maximum production of bioethanol from flowering to physiological maturity. The canes were crushed and juice fermented to produce ethanol. Measurements of chlorophyll were taken at various stages as well as panicles from the harvested canes. Dried kernels at 14% moisture content were also weighed at various stages. Chlorophyll, grain weight, absolute ethanol volume, juice volume, cane yield, and brix showed significant (p = 0.05) differences for genotypes as well as the stages of harvesting. Results from this study showed that harvesting sweet sorghum at stages IV and V (104 to 117 days after planting) would be appropriate for production of kernels and ethanol. EUSS10 has the highest ethanol potential (1062.78 l ha−1) due to excellent juice volume (22976.9 l ha−1) and EUSS11 (985.26 l ha−1) due to its high brix (16.21). PMID:28255577

  5. Effect of Harvesting Stage on Sweet Sorghum (Sorghum bicolor L. Genotypes in Western Kenya

    Directory of Open Access Journals (Sweden)

    Moses Owuor Oyier

    2017-01-01

    Full Text Available Harvesting stage of sweet sorghum (Sorghum bicolor L. Moench cane is an important aspect in the content of sugar for production of industrial alcohol. Four sweet sorghum genotypes were evaluated for harvesting stage in a randomized complete block design. In order to determine sorghum harvest growth stage for bioethanol production, sorghum canes were harvested at intervals of seven days after anthesis. The genotypes were evaluated at different stages of development for maximum production of bioethanol from flowering to physiological maturity. The canes were crushed and juice fermented to produce ethanol. Measurements of chlorophyll were taken at various stages as well as panicles from the harvested canes. Dried kernels at 14% moisture content were also weighed at various stages. Chlorophyll, grain weight, absolute ethanol volume, juice volume, cane yield, and brix showed significant (p=0.05 differences for genotypes as well as the stages of harvesting. Results from this study showed that harvesting sweet sorghum at stages IV and V (104 to 117 days after planting would be appropriate for production of kernels and ethanol. EUSS10 has the highest ethanol potential (1062.78 l ha−1 due to excellent juice volume (22976.9 l ha−1 and EUSS11 (985.26 l ha−1 due to its high brix (16.21.

  6. Evidences for viral strain selection in late stages of HIV infection: an analysis of Vpu alleles.

    Science.gov (United States)

    Gondim, Marcos Vinícius Pereira; da Silva, Joaquim Xavier; Prosdocimi, Francisco; Leonardecz-Neto, Eduardo; Franco, Octávio Luiz; Argañaraz, Enrique Roberto

    2012-02-01

    One of the most studied topics about AIDS disease is the presence of different progression levels in patients infected by HIV. Several studies have shown that this progression is directly associated with host genetics, although viral factors are also known to play a role. Here we explore the contribution of Vpu protein in the evolution of viral population. The sequence variation of Vpu was analyzed during HIV infection in peripheral blood monocyte cells of 12 patients in different clinical stages of HIV-1 infection early and late stages of infections, separated by at least 4 years. The clustering analysis of Vpu sequences showed higher diversity of early alleles, non-random distribution of sequences, and viral evolution strains selection. Forty-two amino acid modifications were found in the multiple alignments of the 57 different alleles found for early stage were 23 modifications were found in the late stage dataset. Interestingly fourteen alteration of early stage were located in conserved site related with Vpu functions alterations while these alterations appear with less frequency in the late stage of infection. Moreover, late stage alleles tend to be similar with the Vpu wild type sequence, suggesting viral selection toward populations harboring more efficient variants during the course of infection. This would contribute to higher infectivity and viral replication actually observed at the aggressive late stages of infection. These data, in conjunction with in vitro experiments, will be important to elucidation of the physiological relevance of Vpu protein in the pathogenic mechanisms of AIDS.

  7. CLASSIFYNG SUCCESSIONAL FOREST STAGES USING IKONOS IN ATLANTIC FOREST OF RIO DE JANEIRO

    Directory of Open Access Journals (Sweden)

    Danielle P. Cintra, Luiz Felipe Guanaes Rego, Rogério Ribeiro Oliveira

    2011-07-01

    Full Text Available Due to the advancement of urban areas on the Atlantic Forest, it is needed constant monitoring of this biome, particularly concerning the Conservation Units. This work was conducted in the Pedra Branca State Park, metropolitan area of the municipal district of Rio de Janeiro. The goal of the study was to differentiate forest succession stages through visual interpretation of a high resolution orbital image. The image classification obeys a hierarchy of classes from a general level (Level I to a specific level (Level II. The forest formations were classified according to the Brazilian forest law in different secondary successional stages, as early, middle, and advanced stages, besides primary forest. It was verified that 83% of the total area of the basin of the Camorim river are covered by forest in different stages of ecological succession. The areas in more advanced stage of succession (advanced stage and primary forest had equalized in extension to the areas in early stage (middle and early stages, occupying 336 ha (42% and 328 ha (41%, respectively. This means that despite the great human pressure that it suffers in its neighborhood, the study site still keeps important remnants for the Atlantic Forest conservation.

  8. Effect of silver nanoparticles on Pseudomonas putida biofilms at different stages of maturity.

    Science.gov (United States)

    Thuptimdang, Pumis; Limpiyakorn, Tawan; McEvoy, John; Prüß, Birgit M; Khan, Eakalak

    2015-06-15

    This study determined the effect of silver nanoparticles (AgNPs) on Pseudomonas putida KT2440 biofilms at different stages of maturity. Three biofilm stages (1-3, representing early to late stages of development) were identified from bacterial adenosine triphosphate (ATP) activity under static (96-well plate) and dynamic conditions (Center for Disease Control and Prevention biofilm reactor). Extracellular polymeric substance (EPS) levels, measured using crystal violet and total carbohydrate assays, and expression of the EPS-associated genes, csgA and alg8, supported the conclusion that biofilms at later stages were older than those at earlier stages. More mature biofilms (stages 2 and 3) showed little to no reduction in ATP activity following exposure to AgNPs. In contrast, the same treatment reduced ATP activity by more than 90% in the less mature stage 1 biofilms. Regardless of maturity, biofilms with EPS stripped off were more susceptible to AgNPs than controls with intact EPS, demonstrating that EPS is critical for biofilm tolerance of AgNPs. The findings from this study show that stage of maturity is an important factor to consider when studying effect of AgNPs on biofilms.

  9. The impact of 18-fluorodeoxyglucose positron emission tomography on the staging, management and outcome of anal cancer

    OpenAIRE

    De Winton, E.; Heriot, A. G.; Ng, M; Hicks, R.J.; Hogg, A; Milner, A.; Leong, T; Fay, M; MacKay, J.; Drummond, E.; Ngan, S Y

    2009-01-01

    Accurate inguinal and pelvic nodal staging in anal cancer is important for the prognosis and planning of radiation fields. There is evidence for the role of 18-fluorodeoxyglucose positron emission tomography (FDG-PET) in the staging and management of cancer, with early reports of an increasing role in outcome prognostication in a number of tumours. We aimed to determine the effect of FDG-PET on the nodal staging, radiotherapy planning and prognostication of patients with primary anal cancer. ...

  10. The IASLC Mesothelioma Staging Project: Improving Staging of a Rare Disease Through International Participation.

    Science.gov (United States)

    Pass, Harvey; Giroux, Dorothy; Kennedy, Catherine; Ruffini, Enrico; Cangir, Ayten K; Rice, David; Asamura, Hisao; Waller, David; Edwards, John; Weder, Walter; Hoffmann, Hans; van Meerbeeck, Jan P; Nowak, Anna; Rusch, Valerie W

    2016-12-01

    For nearly 40 years, there was no generally accepted staging system for malignant pleural mesothelioma. In 1994, members of the International Mesothelioma Interest Group, in collaboration with the International Association for the Study of Lung Cancer, proposed a TNM staging system based on analyses of outcomes in retrospective surgical series and small clinical trials. Subsequently accepted by the American Joint Commission on Cancer and the Union for International Cancer Control for the sixth editions of their staging manuals, this system has since been the international staging standard. However, it has significant limitations, particularly with respect to clinical staging and to the categories for lymph node staging. Here we provide an overview of the development of the International Association for the Study of Lung Cancer malignant pleural mesothelioma staging database, which was designed to address these limitations through the development of a large international data set. Analyses of this database, described in papers linked to this overview, are being used to inform revisions in the eighth editions of the American Joint Commission on Cancer and Union for International Cancer Control staging systems.

  11. The microorganisms in chronically infected end-stage and non-end-stage cystic fibrosis patients

    DEFF Research Database (Denmark)

    Rudkjøbing, Vibeke Børsholt; Thomsen, Trine Rolighed; Alhede, Morten;

    2012-01-01

    Patients suffering from cystic fibrosis (CF) develop chronic lung infections because of highly viscous mucus, where bacteria can form biofilms. In this study, we investigated the microorganisms present in the lungs of end-stage and non-end-stage patients using standard culturing techniques and mo...

  12. Treatment results in women with clinical stage I and pathologic stage II endometrial carcinoma.

    Science.gov (United States)

    Jobsen, J J; Schutter, E M; Meerwaldt, J H; Van Der Palen, J; Van Der Sijde, R; Ten Cate, L N

    2001-01-01

    The aim of this study is to report survival and results of therapy and possible prognostic factors in women with pathologic stage II endometrial carcinoma. Forty-two patients with pathologic stage II endometrial carcinoma were treated at the department of Radiation Oncology of the Medisch Spectrum Twente between 1987 and 1998. All patients received external radiotherapy following standard surgical procedures and no adjuvant systemic therapy was given. From the 42 patients 21 had a pathologic stage IIA and 21 stage IIB. The median follow-up was 62 months. The overall recurrence rate was 21.5% (9/42). Seven patients had distant metastasis, of which three also had locoregional recurrence, vaginal vault and/or pelvic. The presence of myometrial invasion (> (1/2)) and/or lymph-angioinvasion showed a significant relation with distant metastasis (P = 0.017). Stage IIB showed more recurrences, 33% (7/21). There was a significant different 5-year disease specific survival for stage IIA and IIB, respectively, 95% and 74% (P = 0.0311). Patients with a differentiation grade 3 and stage IIB showed a significantly poorer (P = 0.003) 5-year survival of 48.6% (P = 0.003). Results obtained in the present series of patients are in accordance with the literature. The present treatment policy seems justified, except for patients with pathologic stage IIB and grade 3, in which a more aggressive treatment should be considered.

  13. How orchestra members influence stage acoustic parameters on five different concert hall stages and orchestra pits.

    Science.gov (United States)

    Wenmaekers, R H C; Hak, C C J M; Hornikx, M C J

    2016-12-01

    Stage acoustic parameters aim to quantify the amount of sound energy reflected by the stage and hall boundaries and the energy decay over time. In this research, the effect of orchestra presence on parameter values is investigated. The orchestra is simulated by dressed mannequins, which have been compared with humans with respect to acoustic properties. Impulse response measurements were performed in a concert hall, a theatre, a rehearsal room, and in two orchestra pits. Conditions were empty stage floors, stage floors with music stands and chairs only, and floors occupied by the mannequin orchestra. Results show that the direct and reflected sound levels and the energy decay are significantly affected by the orchestra compared to an empty stage or a stage with chairs and stands only. Both the direct sound and early reflected sound levels are reduced by the orchestra with the distance. The late reflected sound level is reduced considerably more than can be expected based on Barron's revised theory. It can be concluded that measurements on a stage without the orchestra being present results in significant differences. A practical method is presented to perform a "musician friendly" stage acoustic measurement with a real orchestra.

  14. Accuracy of the One-Stage and Two-Stage Impression Techniques: A Comparative Analysis

    Directory of Open Access Journals (Sweden)

    Ladan Jamshidy

    2016-01-01

    Full Text Available Introduction. One of the main steps of impression is the selection and preparation of an appropriate tray. Hence, the present study aimed to analyze and compare the accuracy of one- and two-stage impression techniques. Materials and Methods. A resin laboratory-made model, as the first molar, was prepared by standard method for full crowns with processed preparation finish line of 1 mm depth and convergence angle of 3-4°. Impression was made 20 times with one-stage technique and 20 times with two-stage technique using an appropriate tray. To measure the marginal gap, the distance between the restoration margin and preparation finish line of plaster dies was vertically determined in mid mesial, distal, buccal, and lingual (MDBL regions by a stereomicroscope using a standard method. Results. The results of independent test showed that the mean value of the marginal gap obtained by one-stage impression technique was higher than that of two-stage impression technique. Further, there was no significant difference between one- and two-stage impression techniques in mid buccal region, but a significant difference was reported between the two impression techniques in MDL regions and in general. Conclusion. The findings of the present study indicated higher accuracy for two-stage impression technique than for the one-stage impression technique.

  15. Nitroheterocyclic drugs cure experimental Trypanosoma cruzi infections more effectively in the chronic stage than in the acute stage

    Science.gov (United States)

    Francisco, Amanda Fortes; Jayawardhana, Shiromani; Lewis, Michael D.; White, Karen L.; Shackleford, David M.; Chen, Gong; Saunders, Jessica; Osuna-Cabello, Maria; Read, Kevin D.; Charman, Susan A.; Chatelain, Eric; Kelly, John M.

    2016-01-01

    The insect-transmitted protozoan parasite Trypanosoma cruzi is the causative agent of Chagas disease, and infects 5–8 million people in Latin America. Chagas disease is characterised by an acute phase, which is partially resolved by the immune system, but then develops as a chronic life-long infection. There is a consensus that the front-line drugs benznidazole and nifurtimox are more effective against the acute stage in both clinical and experimental settings. However, confirmative studies have been restricted by difficulties in demonstrating sterile parasitological cure. Here, we describe a systematic study of nitroheterocyclic drug efficacy using highly sensitive bioluminescence imaging of murine infections. Unexpectedly, we find both drugs are more effective at curing chronic infections, judged by treatment duration and therapeutic dose. This was not associated with factors that differentially influence plasma drug concentrations in the two disease stages. We also observed that fexinidazole and fexinidazole sulfone are more effective than benznidazole and nifurtimox as curative treatments, particularly for acute stage infections, most likely as a result of the higher and more prolonged exposure of the sulfone derivative. If these findings are translatable to human patients, they will have important implications for treatment strategies. PMID:27748443

  16. Importance of Campylobacter jejuni for Food Safety and Public Health

    Directory of Open Access Journals (Sweden)

    Omer Cakmak

    2010-04-01

    Full Text Available Campylobacter spp. are microorganisms that can be found in nature in the entire domestic and wild animal’s intestinal flora including the poultry and the sea animals. Campylobacter can better colonize in the poultry than the other animals. Campylobacter jejuni is an important pathogen among the thermophilic Campylobacter spp. whose growth temperature’s are different than the other Campylobacter spp. and can cause serious gastroenteritis in human beings which in some cases ended up with death. Human beings are generally infected with C. jejuni mainly because of the poultry meat and products and rarely because of the red meat which are contaminated during preparation and serving stages. Inadequate cooking, consumption of poorly chlorinated drinking water or unpasteurized milk are other infection sources of C. jejuni. Campylobacteriosis especially affect children under 5 years of age and reported to be a zoonotic illness that cause acute gastroenteritis in human. In many countries, food sourced C. jejuni infections were reported to occur more frequently than Salmonella spp. infections. In order to avoid Campylobacter infections, it is very important to enforce food security programmes and HACCP like systems during growth, slaughterhouses and point of sales stages. Also adequate cooking of the products, hygiene of the kitchen and personnel are important. [TAF Prev Med Bull 2010; 9(2.000: 157-166

  17. The Importance of Probation under the Current Circumstances

    Directory of Open Access Journals (Sweden)

    Minodora-Ioana Balan-Rusu

    2011-05-01

    Full Text Available Implemented in our legislation with the entry into force of the Criminal Code of Charles II, theprobation system has been developed continuously, increasing its importance from one stage to another.Thus, under the current circumstances, the probation service has a crucial role in the complex activity ofrehabilitating the person sentenced to a deprivation of liberty sentence through community supervision ofthe measures and obligations imposed by the court to the convicted. Although the most important tasks ofthe service are those of monitoring sanctions and of measures ordered by the court, however, this institutionperforms other activities almost equally important in the stage of trial and of execution of custodialsentences. Among the core values of probation that were imposed in recent years both in our country and inthe European Union are: respect for persons, reconciliation between offenders and the communities towhich they belong, non-discrimination in the community of persons who have committed criminal acts,supporting and encouraging permanently these individuals to form a correct attitude towards work, the ruleof law and to obey the rules of social life. The research of the legal rules that govern the probation serviceactivity highlights some shortcomings as well, which should be corrected, the ultimate goal being that ofmaking them compatible with the EU norms, especially in the cooperating area which must be achievedbetween these institutions at European level.

  18. An actuarial approach to comparing early stage and late stage lung cancer mortality and survival.

    Science.gov (United States)

    Goldberg, Sara W; Mulshine, James L; Hagstrom, Dale; Pyenson, Bruce S

    2010-02-01

    Comparing the mortality characteristics of different cohorts is an essential process in the life insurance industry. Pseudodisease, lead-time bias, and length bias, which are critical to determining the value of cancer screening, have close analogues in life insurance company management, including the temporal impact of underwriting. Ratios of all-cause mortality rates for cancer cohorts relative to standard population mortality rates can provide insights into early stage and late stage mortality differences, differences by age, sex, race, and histology, and allow modeling of biases associated with early stage detection or screening protocols. The Surveillance, Epidemiology and End Results (SEER) data set has characteristics that allow efficient application of actuarial techniques. We show the mortality burden associated with treated early stage lung cancer and that identifying all lung cancers at early stage could reduce US lung cancer deaths by over 70,000 per year.

  19. Staging Events of Collaborative Design and Learning

    DEFF Research Database (Denmark)

    Binder, Thomas; Brandt, Eva; Horgen, Turid

    1998-01-01

    In this paper we will focus on events where collaborating parties get together to further the design work, and on how these events get staged in time and space. Our consern is the micro-organisation of time and space, which we find is poorly explored in the literature on product development. We...

  20. Treatment Options by Stage (Hypopharyngeal Cancer)

    Science.gov (United States)

    ... of the hypopharynx . These abnormal cells may become cancer and spread into nearby normal tissue . Stage 0 is also called carcinoma in situ . Enlarge Tumor sizes. The size of a tumor may be compared to the size of a pea (1 cm), peanut (2 cm), grape (3 cm), walnut (4 cm), lime (5 cm), ...